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Gene: ML0700

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene nameadd
Accession numberML0700
TypeCDS
FunctionCATALYZES HYDROLYTIC DEAMINATION OF ADENOSINE AND GENERATES INOSINE [CATALYTIC ACTIVITY: ADENOSINE + H(2)O = INOSINE + NH(3) (ALSO MAY ACT ON DEOXYADENOSINE)].
ProductProbable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)
CommentsML0700, len: 362 aa. Probable add, adenosine deaminase (EC 3.5.4.4), highlt similar to O53365|AL123456|Rv3313c add, probable adenosine deaminase from M. tuberculosis (365 aa), Fasta scores: E(): 0, (88.2% identity in 356 aa overlap). Similar to many e.g. Q9AK25|ADD5_STRCO Probable adenosine deaminase 5 from Streptomyces coelicolor (396 aa), fasta scores: E(): 9.9e-99, 66.856% identity in 353 aa overlap); and ADD_ECOLI|P22333 add, adenosine deaminase from Escherichia coli (333 aa), Fasta scores: E(): 6.8e-19, (29.7% identity in 340 aa overlap). Previously sequenced as Q49907|U00022 (332 aa), Fasta scores: E(): 0, (99.7% identity in 332 aa overlap). Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase. BELONGS TO THE ADENOSINE AND AMP DEAMINASES FAMILY.
Molecular mass (Da)39637
Isoelectric point5.13
Gene length (bp)1089
Protein length363
Location (kb)837.68


Functional categoryintermediary metabolism and respiration


Annotation Changescoordinates updated on 11-AUG-2009


Coordinates
TypeStartEndOrientation
CDS837680838768+


Protein sequence in FASTA format
>M. leprae TN | add
MNTPLHLENIKQAPKALLHDHLDGGLRPATVLDIAGQVGYDRLPATDVESLETWFRTASHSGSLERYLEPFSHTVAVMQT
PEALHRVAYECVEDLAADSVVYAEVRFAPELHIDEGLSFDEVLASVLAGFADGERACAAEGNAITVRCLVTAMRHAAMSR
EIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRSNNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDI
DVDPGGGIRLGPLASILRDKRIPLELCPSSNLQTGAVASITEHPFDLLAWARFRVTVNTDNRLMSDTSMSLEMHRLVEAF
GYGWGDLERFTINAMKSAFIPFDQRLAIIDEVIKPRFAVLVG*
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Genomic sequence

Add extra bases upstream (5') and downstream (3')



Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
Enzyme Classification3.5.4.4
Gene Ontologyadenosine deaminase activity
purine ribonucleoside monophosphate biosynthetic process
MtuberculosisRv3313c
UniProtQ9CCL9


Interacting Drugs/Compounds
TDR TargetsML0700