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Gene: ML1731

General annotation | Coordinates | Sequence | Genome Browser | Structural information | Orthologs/Cross-references | Interacting Drugs/Compounds | Bibliography


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General annotation
Gene namenrdF
Accession numberML1731c
Synonym(s)nrdF2
TypeCDS
FunctionINVOLVED IN THE DNA REPLICATION PATHWAY. CATALYZES THE BIOSYNTHESIS OF DEOXYRIBONUCLEOTIDES FROM THE CORRESPONDING RIBONUCLEOTIDES, PRECURSORS THAT ARE NECESSARY FOR DNA SYNTHESIS [CATALYTIC ACTIVITY: 2'-DEOXYRIBONUCLEOSIDE DIPHOSPHATE + OXIDIZED THIOREDOXIN + H(2)O = RIBONUCLEOSIDE DIPHOSPHATE + REDUCED THIOREDOXIN].
ProductRIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN)
Evidenceexperimental (in M. tuberculosis)
CommentsML1731c, len: 325 aa. Probable nrdF, ribonucleoside-diphosphate reductase, beta chain (EC 1.17.4.1). Highly similar to many ribonucleoside-diphosphate reductase 2 beta chains, involved in DNA replication, including: Escherichia coli SW:RIR4_ECOLI (P37146) (319 aa), Fasta scores: E(): 0, 71.6% identity in 320 aa overlap and Mycobacterium tuberculosis Rv3048c TR:Q50549 (EMBL:AL021287) (324 aa), Fasta scores: E(): 0, 93.5% identity in 324 aa overlap. Contains Pfam match to entry PF00268 ribonuc_red, Ribonucleotide reductases. Contains PS00368 Ribonucleotide reductase small subunit signature.
Molecular mass (Da)37297.9
Isoelectric point4.43
Gene length (bp)978
Protein length326
Location (kb)2091.6


Functional categoryinformation pathways


Annotation Changescoordinates updated on 11-AUG-2009


Coordinates
TypeStartEndOrientation
CDS20906202091597-


Protein sequence in FASTA format
>M. leprae TN | nrdF
LLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWLPEKVPVSNDLPSWGTLTASEKQLTMRVFTGLTLLDTIQGTVG
AVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTAEIDEAFRWSEENNNLQRKAKIVMEYYRGDEPLKRKVAS
TLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDNEV
EYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTED
EDWDF*
Blastp: results
TransMembrane prediction using Hidden Markov Models: tmhmm
Microbe Genome Browser
Genomic sequence

Add extra bases upstream (5') and downstream (3')



Structural information
Protein Data BankNo structure available
PFAMProtein Family Domains


Orthologs/Cross-references
Enzyme Classification1.17.4.1
Gene Ontologyribonucleoside-diphosphate reductase activity
iron ion binding
DNA replication
deoxyribonucleoside diphosphate metabolic process
oxidation reduction
MtuberculosisRv3048c
UniProtQ9CBQ2


Interacting Drugs/Compounds
TDR TargetsML1731