BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0067c Length=189 Score E Sequences producing significant alignments: (Bits) Value gi|15607209|ref|NP_214581.1| TetR family transcriptional regulat... 375 2e-102 gi|289441435|ref|ZP_06431179.1| transcriptional regulator, tetR-... 374 4e-102 gi|167970595|ref|ZP_02552872.1| hypothetical transcriptional reg... 361 3e-98 gi|339296788|gb|AEJ48898.1| TetR family transcriptional regulato... 340 5e-92 gi|289567954|ref|ZP_06448181.1| transcriptional regulator, tetR-... 338 2e-91 gi|342859056|ref|ZP_08715710.1| putative TetR/AcrR-family transc... 248 2e-64 gi|296167993|ref|ZP_06850106.1| TetR family transcriptional regu... 248 2e-64 gi|333989069|ref|YP_004521683.1| transcriptional regulator [Myco... 243 8e-63 gi|15827081|ref|NP_301344.1| TetR/AcrR family transcriptional re... 233 8e-60 gi|4154041|emb|CAA22690.1| putative transcriptional regulator [M... 233 1e-59 gi|169627750|ref|YP_001701399.1| transcriptional regulator TetR ... 221 3e-56 gi|118468552|ref|YP_885281.1| transcriptional regulator [Mycobac... 221 3e-56 gi|120401778|ref|YP_951607.1| TetR family transcriptional regula... 191 4e-47 gi|158430480|pdb|2QWT|A Chain A, Crystal Structure Of The Tetr T... 190 9e-47 gi|126433209|ref|YP_001068900.1| TetR family transcriptional reg... 181 7e-44 gi|108797586|ref|YP_637783.1| TetR family transcriptional regula... 179 2e-43 gi|145220747|ref|YP_001131425.1| TetR family transcriptional reg... 177 6e-43 gi|296395377|ref|YP_003660261.1| TetR family transcriptional reg... 159 1e-37 gi|317509371|ref|ZP_07966990.1| tetR family bacterial regulatory... 159 2e-37 gi|315442300|ref|YP_004075179.1| TetR family transcriptional reg... 158 4e-37 gi|297157381|gb|ADI07093.1| transcriptional regulator, TetR fami... 131 6e-29 gi|302527438|ref|ZP_07279780.1| predicted protein [Streptomyces ... 124 9e-27 gi|312198052|ref|YP_004018113.1| TetR family transcriptional reg... 123 1e-26 gi|331694712|ref|YP_004330951.1| regulatory protein TetR [Pseudo... 120 9e-26 gi|340523588|gb|AEK38793.1| TetR family transcriptional regulato... 119 2e-25 gi|291301359|ref|YP_003512637.1| TetR family transcriptional reg... 119 3e-25 gi|229821806|ref|YP_002883332.1| TetR family transcriptional reg... 119 3e-25 gi|288919414|ref|ZP_06413747.1| transcriptional regulator, TetR ... 118 4e-25 gi|256395254|ref|YP_003116818.1| TetR family transcriptional reg... 117 6e-25 gi|291299900|ref|YP_003511178.1| TetR family transcriptional reg... 117 9e-25 gi|302531670|ref|ZP_07284012.1| predicted protein [Streptomyces ... 117 1e-24 gi|271966497|ref|YP_003340693.1| TetR family transcriptional reg... 113 1e-23 gi|145596475|ref|YP_001160772.1| regulatory protein TetR [Salini... 110 1e-22 gi|254381787|ref|ZP_04997151.1| transcriptional regulator [Strep... 110 1e-22 gi|300786560|ref|YP_003766851.1| TetR family transcriptional reg... 110 1e-22 gi|29469227|gb|AAO65340.1| putative TetR/AcrR-family transcripti... 110 1e-22 gi|158314411|ref|YP_001506919.1| TetR family transcriptional reg... 107 1e-21 gi|148252455|ref|YP_001237040.1| TetR family transcriptional reg... 105 4e-21 gi|312198127|ref|YP_004018188.1| TetR family transcriptional reg... 105 4e-21 gi|146343433|ref|YP_001208481.1| TetR family transcriptional reg... 105 4e-21 gi|329937461|ref|ZP_08287019.1| TetR family transcriptional regu... 104 5e-21 gi|256380192|ref|YP_003103852.1| TetR family transcriptional reg... 104 6e-21 gi|111223256|ref|YP_714050.1| TetR family transcriptional regula... 104 8e-21 gi|111221504|ref|YP_712298.1| TetR family transcriptional regula... 103 1e-20 gi|302539770|ref|ZP_07292112.1| TetR family transcriptional regu... 102 2e-20 gi|217979434|ref|YP_002363581.1| TetR family transcriptional reg... 102 3e-20 gi|345002575|ref|YP_004805429.1| TetR family transcriptional reg... 102 3e-20 gi|328884637|emb|CCA57876.1| Transcriptional regulator, TetR fam... 102 4e-20 gi|300784394|ref|YP_003764685.1| TetR family transcriptional reg... 101 5e-20 gi|288920689|ref|ZP_06414991.1| transcriptional regulator, TetR ... 101 5e-20 >gi|15607209|ref|NP_214581.1| TetR family transcriptional regulator [Mycobacterium tuberculosis H37Rv] gi|15839446|ref|NP_334483.1| TetR family transcriptional regulator [Mycobacterium tuberculosis CDC1551] gi|31791244|ref|NP_853737.1| TetR family transcriptional regulator [Mycobacterium bovis AF2122/97] 62 more sequence titles Length=189 Score = 375 bits (963), Expect = 2e-102, Method: Compositional matrix adjust. Identities = 188/189 (99%), Positives = 189/189 (100%), Gaps = 0/189 (0%) Query 1 LAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEAL 60 +APTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEAL Sbjct 1 MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEAL 60 Query 61 FQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISS 120 FQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISS Sbjct 61 FQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISS 120 Query 121 AAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVA 180 AAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVA Sbjct 121 AAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVA 180 Query 181 LDGLRANRK 189 LDGLRANRK Sbjct 181 LDGLRANRK 189 >gi|289441435|ref|ZP_06431179.1| transcriptional regulator, tetR-family [Mycobacterium tuberculosis T46] gi|289748533|ref|ZP_06507911.1| transcriptional regulator, tetR-family [Mycobacterium tuberculosis T92] gi|289756127|ref|ZP_06515505.1| transcriptional regulator [Mycobacterium tuberculosis EAS054] gi|289414354|gb|EFD11594.1| transcriptional regulator, tetR-family [Mycobacterium tuberculosis T46] gi|289689120|gb|EFD56549.1| transcriptional regulator, tetR-family [Mycobacterium tuberculosis T92] gi|289696714|gb|EFD64143.1| transcriptional regulator [Mycobacterium tuberculosis EAS054] Length=189 Score = 374 bits (959), Expect = 4e-102, Method: Compositional matrix adjust. Identities = 187/189 (99%), Positives = 189/189 (100%), Gaps = 0/189 (0%) Query 1 LAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEAL 60 +APTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEAL Sbjct 1 MAPTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEAL 60 Query 61 FQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISS 120 FQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISS Sbjct 61 FQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISS 120 Query 121 AAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVA 180 AAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVL+VKTLLVGCQAMQSYNAELAAKVTDVA Sbjct 121 AAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLDVKTLLVGCQAMQSYNAELAAKVTDVA 180 Query 181 LDGLRANRK 189 LDGLRANRK Sbjct 181 LDGLRANRK 189 >gi|167970595|ref|ZP_02552872.1| hypothetical transcriptional regulatory protein, tetR-family [Mycobacterium tuberculosis H37Ra] gi|254548999|ref|ZP_05139446.1| transcriptional regulator, tetR-family protein [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|294995685|ref|ZP_06801376.1| transcriptional regulator, tetR-family protein [Mycobacterium tuberculosis 210] 6 more sequence titles Length=182 Score = 361 bits (926), Expect = 3e-98, Method: Compositional matrix adjust. Identities = 181/182 (99%), Positives = 182/182 (100%), Gaps = 0/182 (0%) Query 8 VRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIAD 67 +RADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIAD Sbjct 1 MRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIAD 60 Query 68 RMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA 127 RMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA Sbjct 61 RMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA 120 Query 128 DFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRAN 187 DFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRAN Sbjct 121 DFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRAN 180 Query 188 RK 189 RK Sbjct 181 RK 182 >gi|339296788|gb|AEJ48898.1| TetR family transcriptional regulator [Mycobacterium tuberculosis CCDC5180] Length=170 Score = 340 bits (873), Expect = 5e-92, Method: Compositional matrix adjust. Identities = 169/170 (99%), Positives = 170/170 (100%), Gaps = 0/170 (0%) Query 20 LEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHAL 79 +EVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHAL Sbjct 1 MEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHAL 60 Query 80 LKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRA 139 LKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRA Sbjct 61 LKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRA 120 Query 140 AQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK 189 AQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK Sbjct 121 AQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK 170 >gi|289567954|ref|ZP_06448181.1| transcriptional regulator, tetR-family [Mycobacterium tuberculosis T17] gi|289541707|gb|EFD45356.1| transcriptional regulator, tetR-family [Mycobacterium tuberculosis T17] Length=170 Score = 338 bits (868), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 168/170 (99%), Positives = 170/170 (100%), Gaps = 0/170 (0%) Query 20 LEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHAL 79 +EVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHAL Sbjct 1 MEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHAL 60 Query 80 LKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRA 139 LKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRA Sbjct 61 LKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLRA 120 Query 140 AQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK 189 AQRAGTVRPDVDVL+VKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK Sbjct 121 AQRAGTVRPDVDVLDVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK 170 >gi|342859056|ref|ZP_08715710.1| putative TetR/AcrR-family transcriptional regulator [Mycobacterium colombiense CECT 3035] gi|342133297|gb|EGT86500.1| putative TetR/AcrR-family transcriptional regulator [Mycobacterium colombiense CECT 3035] Length=190 Score = 248 bits (634), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 122/171 (72%), Positives = 144/171 (85%), Gaps = 0/171 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VL+VAY TFAA+GLSVP+DE+ARRAGVGAGTVYRHFPTKEALFQAVI DRM R++D G A Sbjct 19 VLDVAYDTFAAEGLSVPIDEVARRAGVGAGTVYRHFPTKEALFQAVIEDRMQRLVDDGRA 78 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL S PG+ALFA LRSMVL WGA DRGLV+ALAG GI+I++AAP+AE FL +L +LLR Sbjct 79 LLDSVGPGEALFALLRSMVLHWGAADRGLVDALAGFGIDIATAAPDAEDAFLAMLDELLR 138 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANRK 189 AAQRAGT R D+ V EVK ++VGCQA ++YN +LA +VTDV +DGLRA R Sbjct 139 AAQRAGTARQDISVREVKAIMVGCQAAEAYNPDLAERVTDVVVDGLRAGRS 189 >gi|296167993|ref|ZP_06850106.1| TetR family transcriptional regulator [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295896919|gb|EFG76546.1| TetR family transcriptional regulator [Mycobacterium parascrofulaceum ATCC BAA-614] Length=188 Score = 248 bits (634), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 122/170 (72%), Positives = 145/170 (86%), Gaps = 0/170 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VL+VAY TFAA+GLSVP+DE+ARRAGVGAGTVYRHFPTKEALF AVI +RM R++D GHA Sbjct 19 VLDVAYATFAAEGLSVPIDEVARRAGVGAGTVYRHFPTKEALFTAVIENRMQRLVDDGHA 78 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL+++ PG+ALFAFLRSMVLQWGA DRGLV+ALAG GI+I AAPEAE F +L +LLR Sbjct 79 LLETEGPGEALFAFLRSMVLQWGAADRGLVDALAGYGIDIECAAPEAEDAFKAMLGELLR 138 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANR 188 AAQRAGT R DVD+ +VK +LVGCQAMQ+Y++ LA + TDV +DGLR R Sbjct 139 AAQRAGTARRDVDMRDVKAILVGCQAMQAYDSGLAERATDVVIDGLRPPR 188 >gi|333989069|ref|YP_004521683.1| transcriptional regulator [Mycobacterium sp. JDM601] gi|333485037|gb|AEF34429.1| transcriptional regulatory protein [Mycobacterium sp. JDM601] Length=188 Score = 243 bits (621), Expect = 8e-63, Method: Compositional matrix adjust. Identities = 120/170 (71%), Positives = 141/170 (83%), Gaps = 0/170 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAY+TFAA+GLSVPVDEIARRAGVG GTVYRHFPTK+ LF+AV+ DRM ++D+G A Sbjct 19 VLEVAYETFAAEGLSVPVDEIARRAGVGPGTVYRHFPTKDELFRAVVNDRMQHVVDEGQA 78 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL+S PG A+F FLRS+VLQWGA DRGL EALAGVGI+I AAPE+E FL +L LLR Sbjct 79 LLESDDPGMAIFTFLRSIVLQWGAADRGLAEALAGVGIDIGQAAPESEEAFLAVLGALLR 138 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANR 188 A Q AGTVR D+ V EVK +LVGCQAMQSY++ +A +VTDV +DGLRA R Sbjct 139 AGQLAGTVRQDLGVREVKAILVGCQAMQSYSSAMAERVTDVVMDGLRAPR 188 >gi|15827081|ref|NP_301344.1| TetR/AcrR family transcriptional regulator [Mycobacterium leprae TN] gi|221229559|ref|YP_002502975.1| putative TetR/AcrR-family transcriptional regulator [Mycobacterium leprae Br4923] gi|13092629|emb|CAC29824.1| putative TetR/AcrR-family transcriptional regulator [Mycobacterium leprae] gi|219932666|emb|CAR70409.1| putative TetR/AcrR-family transcriptional regulator [Mycobacterium leprae Br4923] Length=200 Score = 233 bits (595), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 117/171 (69%), Positives = 139/171 (82%), Gaps = 1/171 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 +L VAY+ FA +GLSVP+DEIARRAGVGAGTVYRHFPTKEAL AVI DRM ++D G+ Sbjct 30 ILGVAYEAFATEGLSVPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYV 89 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGV-GIEISSAAPEAEADFLDLLTDLL 137 LLKS PG+ALF +LRS+VL WGATDRGLV+ALAG GI+I AP+AE FL +L+DLL Sbjct 90 LLKSAGPGEALFTYLRSLVLHWGATDRGLVDALAGAGGIDILGVAPDAEDAFLTILSDLL 149 Query 138 RAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANR 188 AAQ AGT R DV V EVK++LVGCQAM++YN+ LA +VTDV +DGLRA R Sbjct 150 YAAQYAGTARTDVGVREVKSILVGCQAMEAYNSALAERVTDVVVDGLRAAR 200 >gi|4154041|emb|CAA22690.1| putative transcriptional regulator [Mycobacterium leprae] Length=189 Score = 233 bits (594), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 117/171 (69%), Positives = 139/171 (82%), Gaps = 1/171 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 +L VAY+ FA +GLSVP+DEIARRAGVGAGTVYRHFPTKEAL AVI DRM ++D G+ Sbjct 19 ILGVAYEAFATEGLSVPIDEIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYV 78 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGV-GIEISSAAPEAEADFLDLLTDLL 137 LLKS PG+ALF +LRS+VL WGATDRGLV+ALAG GI+I AP+AE FL +L+DLL Sbjct 79 LLKSAGPGEALFTYLRSLVLHWGATDRGLVDALAGAGGIDILGVAPDAEDAFLTILSDLL 138 Query 138 RAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANR 188 AAQ AGT R DV V EVK++LVGCQAM++YN+ LA +VTDV +DGLRA R Sbjct 139 YAAQYAGTARTDVGVREVKSILVGCQAMEAYNSALAERVTDVVVDGLRAAR 189 >gi|169627750|ref|YP_001701399.1| transcriptional regulator TetR [Mycobacterium abscessus ATCC 19977] gi|169239717|emb|CAM60745.1| Possible transcriptional regulatory protein TetR [Mycobacterium abscessus] Length=187 Score = 221 bits (564), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 110/167 (66%), Positives = 131/167 (79%), Gaps = 1/167 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAYQTFA +GL VP+DEIARRAGVGAGTVYRHFP KE L++A+ DRM +IDKG Sbjct 19 VLEVAYQTFAEEGLGVPIDEIARRAGVGAGTVYRHFPAKEDLYRAIAEDRMGSVIDKGRE 78 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL + PG+ALF FLRSM + WG TD+GLV+AL+G GI++ + P E F +L DLLR Sbjct 79 LLAAVDPGEALFEFLRSM-MDWGGTDQGLVDALSGAGIDVQALIPHIEESFYAVLGDLLR 137 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 AAQ+AGTVR DV V EVK LLVGCQAMQSYN +++ +VTDV DGLR Sbjct 138 AAQQAGTVRSDVGVHEVKALLVGCQAMQSYNKDVSRQVTDVVFDGLR 184 >gi|118468552|ref|YP_885281.1| transcriptional regulator [Mycobacterium smegmatis str. MC2 155] gi|118169839|gb|ABK70735.1| transcriptional regulator [Mycobacterium smegmatis str. MC2 155] Length=189 Score = 221 bits (564), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 108/167 (65%), Positives = 134/167 (81%), Gaps = 0/167 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAY+ FA DGL+VP+DEIARRAGVGAGTVYRHFP+KE L++AV+A+R+ I+D+G A Sbjct 14 VLEVAYEAFAQDGLAVPIDEIARRAGVGAGTVYRHFPSKEDLYRAVVAERIREIVDQGQA 73 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL PG+ALF +LR MVLQ GA DRGLVEALAG GI++ + P+AE +++++L LLR Sbjct 74 LLADGDPGEALFDYLRLMVLQCGAADRGLVEALAGAGIDVKTMVPDAEDEYMEMLGGLLR 133 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 AAQRAGTVR DV +VK LLVGCQAMQ+Y+A A +T V DGLR Sbjct 134 AAQRAGTVRGDVTATDVKALLVGCQAMQAYDATAAEHLTGVVFDGLR 180 >gi|120401778|ref|YP_951607.1| TetR family transcriptional regulator [Mycobacterium vanbaalenii PYR-1] gi|119954596|gb|ABM11601.1| transcriptional regulator, TetR family [Mycobacterium vanbaalenii PYR-1] Length=186 Score = 191 bits (486), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 103/167 (62%), Positives = 123/167 (74%), Gaps = 1/167 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAY TFAA+GL VP+DEIARRAGVGAGTVYRHFPTK+AL AV DR+ RI+D Sbjct 16 VLEVAYDTFAAEGLGVPIDEIARRAGVGAGTVYRHFPTKQALVVAVAEDRVRRIVDHART 75 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL ++ PG+ALF FLR MV + A D GLV+AL G G+++ AAP AEA FL L +LL Sbjct 76 LLAAEGPGEALFVFLRDMV-RSAAADYGLVDALVGYGLDLEVAAPGAEAAFLATLGELLA 134 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 AAQRAGTVR DVDV +K LLV C+ Q Y+ E++ +V V DGLR Sbjct 135 AAQRAGTVRADVDVAVIKALLVVCKVPQVYDGEVSERVVRVIEDGLR 181 >gi|158430480|pdb|2QWT|A Chain A, Crystal Structure Of The Tetr Transcription Regulatory Protein From Mycobacterium Vanbaalenii Length=196 Score = 190 bits (482), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 102/167 (62%), Positives = 123/167 (74%), Gaps = 1/167 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAY TFAA+GL VP+DEIARRAGVGAGTVYRHFPTK+AL AV DR+ RI+D Sbjct 18 VLEVAYDTFAAEGLGVPMDEIARRAGVGAGTVYRHFPTKQALVVAVAEDRVRRIVDHART 77 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL ++ PG+ALF F+R MV + A D GLV+AL G G+++ AAP AEA FL L +LL Sbjct 78 LLAAEGPGEALFVFMRDMV-RSAAADYGLVDALVGYGLDLEVAAPGAEAAFLATLGELLA 136 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 AAQRAGTVR DVDV +K LLV C+ Q Y+ E++ +V V DGLR Sbjct 137 AAQRAGTVRADVDVAVIKALLVVCKVPQVYDGEVSERVVRVIEDGLR 183 >gi|126433209|ref|YP_001068900.1| TetR family transcriptional regulator [Mycobacterium sp. JLS] gi|126233009|gb|ABN96409.1| transcriptional regulator, TetR family [Mycobacterium sp. JLS] Length=194 Score = 181 bits (458), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 109/180 (61%), Positives = 142/180 (79%), Gaps = 0/180 (0%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R +RADAARNR RVL VAY+TFAADGL+VPVDEIARRAGVGAGT+YRHFPTKEAL+ AV+ Sbjct 9 RPLRADAARNRDRVLRVAYETFAADGLTVPVDEIARRAGVGAGTIYRHFPTKEALYTAVV 68 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 R++ +I++G LL S PG+ALF FLR++ ++WGA DR L++ LAG G+++ + APEA Sbjct 69 EHRLYEMIERGRELLASGDPGEALFDFLRAIAVEWGAADRVLIDGLAGWGLDVHTVAPEA 128 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 +A LL +LL A QRAGTVR D+ E+K++LVG QA+ +Y+A +AA+ T V DGLR Sbjct 129 DAAARALLAELLAAGQRAGTVRADLTAPELKSILVGLQAIGAYDAAVAARATAVVADGLR 188 >gi|108797586|ref|YP_637783.1| TetR family transcriptional regulator [Mycobacterium sp. MCS] gi|119866673|ref|YP_936625.1| TetR family transcriptional regulator [Mycobacterium sp. KMS] gi|108768005|gb|ABG06727.1| transcriptional regulator, TetR family [Mycobacterium sp. MCS] gi|119692762|gb|ABL89835.1| transcriptional regulator, TetR family [Mycobacterium sp. KMS] Length=194 Score = 179 bits (454), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 108/180 (60%), Positives = 141/180 (79%), Gaps = 0/180 (0%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R +RADAARNR RVL VAY+TFAADGL+VPVDEIARRAGVG GT+YRHFPTKEAL+ AV+ Sbjct 9 RPLRADAARNRDRVLRVAYETFAADGLTVPVDEIARRAGVGPGTIYRHFPTKEALYTAVV 68 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 R++ +I++G LL S PG+ALF FLR++ ++WGA DR L++ LAG G+++ + APEA Sbjct 69 EHRLYEMIERGWELLASGDPGEALFDFLRAIAVEWGAADRVLIDGLAGWGLDVHTVAPEA 128 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 +A LL +LL A QRAGTVR D+ E+K++LVG QA+ +Y+A +AA+ T V DGLR Sbjct 129 DAAARALLAELLAAGQRAGTVRADLTAPELKSILVGLQAIGAYDAAVAARATAVVADGLR 188 >gi|145220747|ref|YP_001131425.1| TetR family transcriptional regulator [Mycobacterium gilvum PYR-GCK] gi|145213233|gb|ABP42637.1| transcriptional regulator, TetR family [Mycobacterium gilvum PYR-GCK] Length=184 Score = 177 bits (449), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 102/170 (60%), Positives = 121/170 (72%), Gaps = 1/170 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAY TFAA+GL+VP+DEIARRAGVGAGTVYRHFPTKEAL AV DR+ RI ++ Sbjct 16 VLEVAYDTFAAEGLTVPIDEIARRAGVGAGTVYRHFPTKEALVVAVAEDRVRRIAERART 75 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL + PG ALF F R MV + A D GLV+AL G+++ + AP EA FL L DLL Sbjct 76 LLAVEGPGQALFVFFRDMV-RSAAVDHGLVDALMNQGLDLEAVAPGVEAAFLSTLGDLLS 134 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANR 188 AAQ AGTVRPDVDV VK LLV C+ Q +++E+ +VT V DGLR R Sbjct 135 AAQGAGTVRPDVDVAVVKALLVVCKVPQVFDSEVTERVTRVIEDGLRPLR 184 >gi|296395377|ref|YP_003660261.1| TetR family transcriptional regulator [Segniliparus rotundus DSM 44985] gi|296182524|gb|ADG99430.1| transcriptional regulator, TetR family [Segniliparus rotundus DSM 44985] Length=204 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 92/185 (50%), Positives = 120/185 (65%), Gaps = 7/185 (3%) Query 3 PTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQ 62 P R +RADAA+NRAR+L VAY+ FA G+ PVDEIARRAGVGAGTVYRHFPTKE LF Sbjct 11 PARRPLRADAAQNRARLLSVAYEAFAELGIGAPVDEIARRAGVGAGTVYRHFPTKEQLFL 70 Query 63 AVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAA 122 AV+ DR+ I+ + +L+++ G+A F F + V+ A D GL +AL G+E+ Sbjct 71 AVVMDRVDHILARAEEVLRTEPAGEAFFTFF-TEVIDQAAVDHGLSDALESSGVEL---- 125 Query 123 PEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSY--NAELAAKVTDVA 180 PE E F + +L+ AQRAGT+R D+ +VK LL C A Q Y + AA +T V Sbjct 126 PEVEDRFRGVSKELVERAQRAGTLRADLVPDDVKFLLKACFAAQRYLEDQSRAAFLTSVV 185 Query 181 LDGLR 185 LDG+R Sbjct 186 LDGMR 190 >gi|317509371|ref|ZP_07966990.1| tetR family bacterial regulatory protein [Segniliparus rugosus ATCC BAA-974] gi|316252294|gb|EFV11745.1| tetR family bacterial regulatory protein [Segniliparus rugosus ATCC BAA-974] Length=193 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 90/185 (49%), Positives = 118/185 (64%), Gaps = 7/185 (3%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R +RADA +NRAR+L+VAY TFA G PVDEIARRAGVGAGTVYRHFPTKE LF AV+ Sbjct 14 RPLRADAVQNRARLLDVAYATFAELGFGAPVDEIARRAGVGAGTVYRHFPTKEQLFLAVV 73 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 A R+ +++ + LL++ P +A F F V GATD+G +AL GIE+ PE Sbjct 74 AVRVDQVLGRAEELLRTAPPEEAFFTFFTETV-DCGATDQGFADALESSGIEL----PEV 128 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSY--NAELAAKVTDVALDG 183 E F +++ L AQ+AGT+R D+ +VK L+ GC A Q Y + + + V LDG Sbjct 129 EERFQEVVRVLFAQAQQAGTLREDLVPEDVKFLMKGCFAAQRYLVDRSRGSFLMSVVLDG 188 Query 184 LRANR 188 +R R Sbjct 189 MRPRR 193 >gi|315442300|ref|YP_004075179.1| TetR family transcriptional regulator [Mycobacterium sp. Spyr1] gi|315260603|gb|ADT97344.1| transcriptional regulator, TetR family [Mycobacterium sp. Spyr1] Length=184 Score = 158 bits (399), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 99/170 (59%), Positives = 119/170 (70%), Gaps = 1/170 (0%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLEVAY TFAA+GL+VP+DEIARRAGVGAGTVYRHFPTKEAL AV DR+ RI ++ Sbjct 16 VLEVAYDTFAAEGLTVPIDEIARRAGVGAGTVYRHFPTKEALVVAVAEDRVRRIAERART 75 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 LL + PG ALF F R MV + A D GLV+AL G+++ + AP EA FL L DLL Sbjct 76 LLAVEGPGQALFVFFRDMV-RSAAVDHGLVDALMSQGLDLEAVAPGVEAAFLSTLGDLLS 134 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLRANR 188 AAQ AGTVR DVDV VK LLV C+ Q +++++ +VT V DGL R Sbjct 135 AAQGAGTVRRDVDVAVVKALLVVCKVPQVFDSQVTERVTRVIEDGLTPVR 184 >gi|297157381|gb|ADI07093.1| transcriptional regulator, TetR family protein [Streptomyces bingchenggensis BCW-1] Length=196 Score = 131 bits (329), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 73/157 (47%), Positives = 97/157 (62%), Gaps = 1/157 (0%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R +RADA RNR R+L A FA +G+++P+DEIARRAGVG GTV+RHFPTKEALF+AV+ Sbjct 6 RPLRADARRNRERILRAARDAFATEGIAIPLDEIARRAGVGPGTVHRHFPTKEALFEAVV 65 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 + + R+ + L G A FAFL M + A + L EA+ G G +S+ Sbjct 66 REHLERLTHEARGALADTAAGPAFFAFLTKMTAEADAK-QDLTEAITGAGGRMSAETEGL 124 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC 162 AD +L LL AQ AG VR DVD +V+ ++VG Sbjct 125 AADLRELFDALLTRAQAAGAVRKDVDAADVQAVVVGA 161 >gi|302527438|ref|ZP_07279780.1| predicted protein [Streptomyces sp. AA4] gi|302436333|gb|EFL08149.1| predicted protein [Streptomyces sp. AA4] Length=189 Score = 124 bits (310), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 74/186 (40%), Positives = 105/186 (57%), Gaps = 6/186 (3%) Query 5 DRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAV 64 D+ +RADA RNRA+VLE A FAA G + P +E+AR AGVG GTV+RHFPTKEAL +AV Sbjct 4 DKPLRADARRNRAKVLEAAETVFAAKGTAAPTEEVAREAGVGIGTVFRHFPTKEALLEAV 63 Query 65 IADRMHRIIDKGHALL--KSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAA 122 + R+HR +D+ A++ ++ G A F FL S + + + EAL G+ + S Sbjct 64 LYARLHRFVDEADAVVAQNAEDAGAAFFTFLTSWI-EMSSAKNAYFEALTSAGVCVPSTG 122 Query 123 PEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSY---NAELAAKVTDV 179 + L LLR AQ +G VR DV E+ +++G + + EL + + Sbjct 123 SVIGERLRESLGVLLRRAQDSGAVRRDVTTTELIPVIIGTAKAAEHVGSDRELRDRTIAI 182 Query 180 ALDGLR 185 DGLR Sbjct 183 LFDGLR 188 >gi|312198052|ref|YP_004018113.1| TetR family transcriptional regulator [Frankia sp. EuI1c] gi|311229388|gb|ADP82243.1| regulatory protein TetR [Frankia sp. EuI1c] Length=213 Score = 123 bits (309), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 83/188 (45%), Positives = 104/188 (56%), Gaps = 9/188 (4%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 RR R DA RNR RVL A F+A G SV +E+AR AGVG GTV+RHFPTKEAL +AV Sbjct 17 RRTRPDARRNRLRVLAAAESVFSARGTSVSTEEVARSAGVGVGTVFRHFPTKEALLEAVF 76 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGI-EISSAA-- 122 RM R ++ L+ + PGDA F FL V+ AT +ALA +G E + AA Sbjct 77 VARMRRFAEEAQELVTAADPGDAFFTFLH-RVVDVAATKATYADALATLGTAEPAGAAQD 135 Query 123 --PEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVG-CQAMQ--SYNAELAAKVT 177 E + L LL AQ+A VR DV V EV LL G C+ + ++ + + Sbjct 136 TLTEGRDELPRALGALLARAQQASAVREDVTVAEVSALLFGACRIAEQAAWRPDALSHTL 195 Query 178 DVALDGLR 185 DV DGLR Sbjct 196 DVVFDGLR 203 >gi|331694712|ref|YP_004330951.1| regulatory protein TetR [Pseudonocardia dioxanivorans CB1190] gi|326949401|gb|AEA23098.1| regulatory protein TetR [Pseudonocardia dioxanivorans CB1190] Length=185 Score = 120 bits (301), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 82/185 (45%), Positives = 106/185 (58%), Gaps = 6/185 (3%) Query 5 DRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAV 64 DR +RADA RNR +VL A + FA G+ VP+DEIA RAGVG GTVYRHFPTKEALF+AV Sbjct 6 DRPLRADARRNREKVLRAAQEAFAEHGMGVPLDEIAGRAGVGPGTVYRHFPTKEALFEAV 65 Query 65 IADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPE 124 +A RM +I A + PG+A F FL +++ R L +AL + + A Sbjct 66 VAARMQDLITAARAGAHAADPGEAFFGFL-ALLADEAGVKRDLSDAL----VAPPAVATS 120 Query 125 AEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAA-KVTDVALDG 183 D L LL AQ+AG VR + V ++ LL G A A+ A ++ V +DG Sbjct 121 LRTDLRAALEVLLTRAQQAGAVRDGIRVDDLFALLKGLMAALVETADDARDRLIAVVVDG 180 Query 184 LRANR 188 LRA R Sbjct 181 LRAPR 185 >gi|340523588|gb|AEK38793.1| TetR family transcriptional regulator [Amycolatopsis mediterranei S699] Length=190 Score = 119 bits (299), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/178 (47%), Positives = 118/178 (67%), Gaps = 4/178 (2%) Query 7 RVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIA 66 ++RADA RNRA+VL A + FA DGL+VP+D+IAR AGVGAGTVYRHFP+KEALFQAV+ Sbjct 3 KMRADARRNRAKVLAAAEEAFALDGLAVPLDDIARLAGVGAGTVYRHFPSKEALFQAVVL 62 Query 67 DRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAE 126 +R+ + ++ AL ++ PG A+F V++ + +R + +ALA G A A Sbjct 63 ERIQQFAEEARALATAEDPG-AVFVDYFVRVIKQASLNRAICDALAESGEHALKAG--AG 119 Query 127 ADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGL 184 +F L +LL AQ AG VRPD+D +++ L+VGC A++ Y A +A + V +DGL Sbjct 120 DEFRAALAELLARAQAAGAVRPDIDGDDLRALIVGCLAVERY-APGSAHLVRVVIDGL 176 >gi|291301359|ref|YP_003512637.1| TetR family transcriptional regulator [Stackebrandtia nassauensis DSM 44728] gi|290570579|gb|ADD43544.1| transcriptional regulator, TetR family [Stackebrandtia nassauensis DSM 44728] Length=299 Score = 119 bits (297), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 80/181 (45%), Positives = 108/181 (60%), Gaps = 6/181 (3%) Query 9 RADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADR 68 RADA RNRA VL A FA+ GLSVP+DEIAR AGVGAGTVYRHFPTK+ALF+AV+A R Sbjct 7 RADARRNRANVLAAAEDLFASQGLSVPLDEIARAAGVGAGTVYRHFPTKDALFEAVMAQR 66 Query 69 MHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA--E 126 + ++ + L+ + A + FL + ++ +R L +A+A E +AA Sbjct 67 IEQLGASAVSALECEDAESAFYEFL-AHAMEQARLNRALCDAMARHD-EWRAAAETTGPH 124 Query 127 ADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAA--KVTDVALDGL 184 F D LLR AQ AG VR DVDV ++ L+ G AM ++ + A ++ + DGL Sbjct 125 CRFTDAFERLLRRAQTAGAVRTDVDVDDLAALIPGYVAMVAHREDEAGARRIRMLLWDGL 184 Query 185 R 185 R Sbjct 185 R 185 >gi|229821806|ref|YP_002883332.1| TetR family transcriptional regulator [Beutenbergia cavernae DSM 12333] gi|229567719|gb|ACQ81570.1| transcriptional regulator, TetR family [Beutenbergia cavernae DSM 12333] Length=185 Score = 119 bits (297), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 78/157 (50%), Positives = 96/157 (62%), Gaps = 1/157 (0%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R+ RADA RNR RVL A + FAADG +VP+DEIARRAGVGAGTVYRHFP+KEALF AVI Sbjct 3 RQPRADARRNRERVLAAAREAFAADGAAVPLDEIARRAGVGAGTVYRHFPSKEALFAAVI 62 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 D + R++ L S PGDA +LR + + GA R L +ALA G + + + Sbjct 63 DDDVARLLADARELATSDDPGDAFLGYLRRLGEEAGAR-RDLADALAVAGFDAGPSFDTS 121 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC 162 + L LL AQ AG VR DV ++ LL G Sbjct 122 APSLQEALGVLLARAQAAGAVRADVGTRDLVALLKGA 158 >gi|288919414|ref|ZP_06413747.1| transcriptional regulator, TetR family [Frankia sp. EUN1f] gi|288349202|gb|EFC83446.1| transcriptional regulator, TetR family [Frankia sp. EUN1f] Length=211 Score = 118 bits (295), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 82/176 (47%), Positives = 107/176 (61%), Gaps = 7/176 (3%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VL A FAADGLSVP+DEIARRAGVGAGTV+RHFPTKEALF AV+ D++ +++ A Sbjct 37 VLRAARDLFAADGLSVPLDEIARRAGVGAGTVHRHFPTKEALFTAVVVDQVEQLVADAAA 96 Query 79 LLKSK-HPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLL 137 + +AL A L M L G L ALAG +I +AAP+ A + L LL Sbjct 97 AYATNTDSSEALLAMLARM-LAEGIESSPLKAALAGTDFDIRTAAPDVAARLRETLHALL 155 Query 138 RAAQRAGTVRPDVDVLEVKTLLVGCQA-MQSYNAELA----AKVTDVALDGLRANR 188 + AQR VR D+DV ++ L+ G A ++ +AE A A++ V DGLRA+R Sbjct 156 QRAQRDRAVRGDIDVDDLFALVAGAFATLRHADAEGAPDRFARLNAVLFDGLRASR 211 >gi|256395254|ref|YP_003116818.1| TetR family transcriptional regulator [Catenulispora acidiphila DSM 44928] gi|256361480|gb|ACU74977.1| transcriptional regulator, TetR family [Catenulispora acidiphila DSM 44928] Length=232 Score = 117 bits (294), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 90/184 (49%), Positives = 112/184 (61%), Gaps = 6/184 (3%) Query 5 DRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAV 64 +R +RADA RNR RVLE A Q FAADG +VP+DEIARRAGVGAGTVYRHFPTKE L AV Sbjct 47 ERPLRADARRNRQRVLEAAAQAFAADGPAVPLDEIARRAGVGAGTVYRHFPTKEELLAAV 106 Query 65 IADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRG-LVEALAGVGIEISSAAP 123 + RM ++ + L PG A +A +M L A D+ L EAL GI++ +A Sbjct 107 LIARMETMLAEVRGALAKPDPGPAFYASFVAMTLD--ARDKTDLAEALTSHGIDVRAATG 164 Query 124 EAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELA--AKVTDVAL 181 E L DLLR AQ AG VR DV V ++ L++G A + +A LA +V + Sbjct 165 EIAGALKAALADLLRRAQDAGAVRADVGVEDLHALVIGAIA-AARSAPLADVPRVAGLVA 223 Query 182 DGLR 185 DGLR Sbjct 224 DGLR 227 >gi|291299900|ref|YP_003511178.1| TetR family transcriptional regulator [Stackebrandtia nassauensis DSM 44728] gi|290569120|gb|ADD42085.1| transcriptional regulator, TetR family [Stackebrandtia nassauensis DSM 44728] Length=259 Score = 117 bits (293), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 77/186 (42%), Positives = 102/186 (55%), Gaps = 13/186 (6%) Query 9 RADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADR 68 RADA RNRA+VL A + FA +G SV + EIA RAGVGAGTVYRHFP+K+ L +AV++ R Sbjct 15 RADARRNRAKVLAAAQRAFAEEGFSVSLGEIANRAGVGAGTVYRHFPSKDDLLEAVLSQR 74 Query 69 MHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA--- 125 + R+ S PG FAF+ VL ++ + + E P A Sbjct 75 IERLTRLADEYGDSADPGAGFFAFV-DEVLSSTTGNKDMCDLF-----ERQDGWPRALLL 128 Query 126 --EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSY--NAELAAKVTDVAL 181 F D L LL AAQR G VR D+D +++ L G AM+ Y AEL ++T + + Sbjct 129 TSGRRFNDALERLLAAAQRHGAVRADIDSADIQELFTGLVAMRRYRDGAELPGRMTLILI 188 Query 182 DGLRAN 187 D LRA Sbjct 189 DTLRAT 194 >gi|302531670|ref|ZP_07284012.1| predicted protein [Streptomyces sp. AA4] gi|302440565|gb|EFL12381.1| predicted protein [Streptomyces sp. AA4] Length=181 Score = 117 bits (292), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 71/158 (45%), Positives = 102/158 (65%), Gaps = 8/158 (5%) Query 30 DGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHALLKSKHPGDAL 89 DGLSVP+D+IAR AGVGAGTVYRHFP+KEALFQAV+ +R+ + + L+ S PG+A Sbjct 28 DGLSVPLDDIARLAGVGAGTVYRHFPSKEALFQAVVVERLEQYGVEAQELIDSDAPGEAF 87 Query 90 FAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA--DFLDLLTDLLRAAQRAGTVR 147 + + + V++ + +R + EAL E S +A +AEA F LT LL AQ AG VR Sbjct 88 YDYF-TRVIEQASRNRAICEALG----ETSGSAYKAEAAERFRVNLTALLERAQAAGAVR 142 Query 148 PDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGLR 185 D+D +++ L+VG A++ + + + + V LDGLR Sbjct 143 ADIDGEDLRALIVGALAVERFTPD-SRHLVRVLLDGLR 179 >gi|271966497|ref|YP_003340693.1| TetR family transcriptional regulator [Streptosporangium roseum DSM 43021] gi|270509672|gb|ACZ87950.1| putative transcriptional regulator, TetR family [Streptosporangium roseum DSM 43021] Length=199 Score = 113 bits (283), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 76/190 (40%), Positives = 103/190 (55%), Gaps = 8/190 (4%) Query 1 LAPTD--RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKE 58 + PTD +RADA RNR R+L A FA G S +E+A RAGV GTV+RHFPTK Sbjct 1 MPPTDDPTPLRADARRNRERILIAAEAVFAEQGASASTEEVAARAGVAIGTVFRHFPTKN 60 Query 59 ALFQAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEI 118 L A+I D M R+ ++ AL P ALF F MV Q + + + L+GVGI++ Sbjct 61 DLLSAIIKDLMRRLTEEADALADHGDPETALFTFFNRMVEQ-AVAKKTVADLLSGVGIDM 119 Query 119 SSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVG-CQAM--QSYNAELAAK 175 A P F + + LL AQ+AGTVR ++ + EV LL CQA + +L + Sbjct 120 RVAKP--VQTFQEAIGALLARAQQAGTVRQEIRLDEVIALLAATCQAALHAGWEPDLQRR 177 Query 176 VTDVALDGLR 185 + +GLR Sbjct 178 TLAIVFEGLR 187 >gi|145596475|ref|YP_001160772.1| regulatory protein TetR [Salinispora tropica CNB-440] gi|145305812|gb|ABP56394.1| regulatory protein, TetR [Salinispora tropica CNB-440] Length=174 Score = 110 bits (275), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 74/183 (41%), Positives = 104/183 (57%), Gaps = 13/183 (7%) Query 8 VRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIAD 67 +R DA RNR R++ VA A G + ++EIA+RAGVGAGT+YRHFPT+E+L V Sbjct 1 MRVDARRNRDRLVAVATAVIAEHGPAASLNEIAQRAGVGAGTLYRHFPTRESLLLEVFTT 60 Query 68 RMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA 127 R+ + ++ L +S+ PGDAL A+L + LQ TDRGL E I A P A+ Sbjct 61 RIETLCERARELAQSRSPGDALTAWLEAF-LQHCLTDRGLAET-------IMKAPPGADL 112 Query 128 DFLDLL----TDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALDG 183 D L DL+ AQ+AG VR ++V ++ L +G A+ + A ++ A DG Sbjct 113 DCAAKLHTAGADLVARAQQAGVVRTGLEVEDILQLTIGI-ALAADGPGRAKRLLSFAFDG 171 Query 184 LRA 186 LRA Sbjct 172 LRA 174 >gi|254381787|ref|ZP_04997151.1| transcriptional regulator [Streptomyces sp. Mg1] gi|194340696|gb|EDX21662.1| transcriptional regulator [Streptomyces sp. Mg1] Length=190 Score = 110 bits (275), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 71/170 (42%), Positives = 98/170 (58%), Gaps = 4/170 (2%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VL+VA + FAA G+ V +EIAR AGVG GT++RHFPTKEAL AV+ R+ + Sbjct 20 VLDVATEVFAARGVGVSTEEIARAAGVGVGTLFRHFPTKEALLAAVMVRRLEVMAAMTAR 79 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 L P +A F+ R +V Q V ALA G+++ ++ E + L LL Sbjct 80 LADRDGPAEAFFSCFRLVVAQSEGKSE-FVRALAAAGVDVHASLQEPTREIQTRLAGLLS 138 Query 139 AAQRAGTVRPDVDVLEVKTLLVGCQAM-QSYNAELAA--KVTDVALDGLR 185 AQRAG VRP++ + E+ LLVG AM + +A+ AA ++ DV DGLR Sbjct 139 EAQRAGAVRPELRMPELLALLVGTGAMVEQLSADPAARERIFDVVFDGLR 188 >gi|300786560|ref|YP_003766851.1| TetR family transcriptional regulator [Amycolatopsis mediterranei U32] gi|299796074|gb|ADJ46449.1| TetR family transcriptional regulator [Amycolatopsis mediterranei U32] gi|340528040|gb|AEK43245.1| TetR family transcriptional regulator [Amycolatopsis mediterranei S699] Length=201 Score = 110 bits (274), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 68/174 (40%), Positives = 95/174 (55%), Gaps = 6/174 (3%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 VLE A FAA G P +E+AR AGVG GTV+RHFPTKEAL +AV+ R+ R +D+ Sbjct 24 VLEAAESVFAAKGTGAPTEEVARVAGVGIGTVFRHFPTKEALLEAVLFARLSRFVDEAET 83 Query 79 LL--KSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDL 136 + +S PG A F FL S V + + +AL G+ + A + A L L L Sbjct 84 AVAAESAEPGRAFFTFLTSWV-EMSSAKNAYFQALTAAGVTVPVAKSDIGARLLTALGVL 142 Query 137 LRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSY---NAELAAKVTDVALDGLRAN 187 L AQ+AG VR D+ V E+ +++G Y +A L + ++ DGLR + Sbjct 143 LSRAQQAGAVRDDLVVGELIPVIIGVARAAEYAGPDATLRDRTVEILFDGLRPS 196 >gi|29469227|gb|AAO65340.1| putative TetR/AcrR-family transcriptional regulator [Streptomyces murayamaensis] Length=197 Score = 110 bits (274), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 73/186 (40%), Positives = 102/186 (55%), Gaps = 7/186 (3%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 RR+RADA RNRARVL A + FA G +V +DE+ARRA VG GT+YRHFPTKEA+ A Sbjct 13 RRLRADAERNRARVLNAARELFAERGANVSMDEVARRAEVGVGTLYRHFPTKEAMVVAAS 72 Query 66 ADRMHRIIDKGHALLK-SKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPE 124 R I+ + + S P +AL L + V + A DRG + G + S P Sbjct 73 QQRFGEILTYYRTVCRESAEPLEALQMLL-TRVGEVEARDRGFASVVGGT---LGSEGPP 128 Query 125 A--EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAELAAKVTDVALD 182 + AD D L DL+ Q AG++R D+ ++ L G ++ + + D+ LD Sbjct 129 STMRADLEDELVDLVGKGQAAGSIRTDIAGADILALTCGLTSIVHRRSGDWRRYIDIVLD 188 Query 183 GLRANR 188 GLR++R Sbjct 189 GLRSDR 194 >gi|158314411|ref|YP_001506919.1| TetR family transcriptional regulator [Frankia sp. EAN1pec] gi|158109816|gb|ABW12013.1| transcriptional regulator, TetR family [Frankia sp. EAN1pec] Length=184 Score = 107 bits (266), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 69/155 (45%), Positives = 89/155 (58%), Gaps = 9/155 (5%) Query 8 VRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIAD 67 +R DA RNR RVL A + FA G + P+DEIA RAGVGAGTVYRHFPTKEALF+AV+A Sbjct 10 LRTDARRNRQRVLHAAREVFAESGFAAPLDEIAARAGVGAGTVYRHFPTKEALFEAVVAA 69 Query 68 RMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA 127 R+ ++ H P A F FL + + T R +A+A G + +A EA Sbjct 70 RVTDLVADAHHRAAEHDPATAFFGFLAVLGAEV-ETKRDTSDAIAVPG-PLGAAMQEA-- 125 Query 128 DFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC 162 L LL AQ+AG VRP+V ++ +L G Sbjct 126 -----LALLLSRAQQAGAVRPEVTAADLVAILKGL 155 >gi|148252455|ref|YP_001237040.1| TetR family transcriptional regulator [Bradyrhizobium sp. BTAi1] gi|146404628|gb|ABQ33134.1| transcriptional regulator, TetR family [Bradyrhizobium sp. BTAi1] Length=196 Score = 105 bits (261), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 71/186 (39%), Positives = 102/186 (55%), Gaps = 3/186 (1%) Query 5 DRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAV 64 R+ RADA RNR RVLE A F+ G ++ +AR+AGVG GT+YRHFPT+E LF+AV Sbjct 9 SRKPRADAQRNRERVLEAAKAVFSVGGAEASLEAVARQAGVGIGTLYRHFPTREDLFEAV 68 Query 65 IADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPE 124 + ++ + AL P +AL +LRS V Q+ AT +G++ ALA V S A Sbjct 69 YRREVEQLSELAEALKSEPSPVEALRRWLRSTV-QFVATKKGMMAALAIVMNANSELAAY 127 Query 125 AEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAM--QSYNAELAAKVTDVALD 182 + + LL A AG +R D+ +V L+G M Q+ + ++ DV +D Sbjct 128 SHGHLTRSIGALLARAVEAGEIRSDISADDVLRALIGMCYMHDQTGWQQSVLRLLDVFVD 187 Query 183 GLRANR 188 GLR + Sbjct 188 GLRVGK 193 >gi|312198127|ref|YP_004018188.1| TetR family transcriptional regulator [Frankia sp. EuI1c] gi|311229463|gb|ADP82318.1| regulatory protein TetR [Frankia sp. EuI1c] Length=194 Score = 105 bits (261), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 68/164 (42%), Positives = 93/164 (57%), Gaps = 6/164 (3%) Query 5 DRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAV 64 +R RADA RNR ++L A + FA +G VP+D IAR AGVG GTV+RHFPTKE+L AV Sbjct 3 ERAPRADALRNRVKILAAAGEAFAREGADVPLDTIARLAGVGPGTVHRHFPTKESLVAAV 62 Query 65 IADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPE 124 + DR+ R+ D+ L P F FL + + R + A +G + S + Sbjct 63 VTDRLDRLADQVERL--DGDPAVDFFDFLADLAREA----RHNLMLTAALGGTLGSDGDQ 116 Query 125 AEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSY 168 A L LLRAAQ+AG VRPD+ V E+ +L G A++ + Sbjct 117 AARRLTGGLDALLRAAQQAGAVRPDLTVAELHAVLGGALAIEQH 160 >gi|146343433|ref|YP_001208481.1| TetR family transcriptional regulator [Bradyrhizobium sp. ORS 278] gi|146196239|emb|CAL80266.1| putative transcriptional regulator, TetR family [Bradyrhizobium sp. ORS 278] Length=203 Score = 105 bits (261), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 72/185 (39%), Positives = 102/185 (56%), Gaps = 3/185 (1%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R+ RADA RNR RVLE A F+ G ++ +AR+AGVG GT+YRHFPT+E LF+AV Sbjct 20 RKPRADAQRNRERVLEAAKAVFSVGGAEASLEAVARQAGVGIGTLYRHFPTREDLFEAVY 79 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 + ++ + L P +AL +LRS V Q+ AT +G++ ALA V S A + Sbjct 80 RREVEQLAELAEELKTEPSPVEALRRWLRSTV-QFVATKKGMMAALAIVMTANSELAAYS 138 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAM--QSYNAELAAKVTDVALDG 183 A + LL A AG +R D+ +V L+G M Q+ + ++ DV +DG Sbjct 139 HAHLTRSIGALLARAVDAGEIRNDIGADDVLRALIGMCYMHDQTGWQQSVLRLLDVFVDG 198 Query 184 LRANR 188 LR R Sbjct 199 LRVQR 203 >gi|329937461|ref|ZP_08287019.1| TetR family transcriptional regulator [Streptomyces griseoaurantiacus M045] gi|329303337|gb|EGG47224.1| TetR family transcriptional regulator [Streptomyces griseoaurantiacus M045] Length=192 Score = 104 bits (260), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 69/186 (38%), Positives = 104/186 (56%), Gaps = 9/186 (4%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R +RADA RN R+L+ A Q FA G ++EIARRAGVG+ T++RHFP++ +L +AV Sbjct 8 RPLRADARRNHQRILDAAQQAFAVHGAGASLEEIARRAGVGSATLHRHFPSRRSLLEAVF 67 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 DR+ + K + PG ALF++LR + AT RGL +LA E A Sbjct 68 RDRVEALCAKARQYARDSEPGTALFSWLRDFN-AYAATCRGLAASLAHE--EREPARVRQ 124 Query 126 EADFLDLLT----DLLRAAQRAGTVRPDVDVLEVKTLL--VGCQAMQSYNAELAAKVTDV 179 + D ++T +LLR AQR+G R + V ++ L+ + + E A ++ D+ Sbjct 125 DEDCTVMITSAAGELLRRAQRSGAARAGLRVDDLLALVGAISLATEHRGDEEQARRLLDI 184 Query 180 ALDGLR 185 A+DG+R Sbjct 185 AIDGVR 190 >gi|256380192|ref|YP_003103852.1| TetR family transcriptional regulator [Actinosynnema mirum DSM 43827] gi|255924495|gb|ACU40006.1| transcriptional regulator, TetR family [Actinosynnema mirum DSM 43827] Length=189 Score = 104 bits (260), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 72/195 (37%), Positives = 104/195 (54%), Gaps = 24/195 (12%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 RR+RADA RN R++ A + F DG ++EIARRAGVG+ T++RHFP ++AL ++V Sbjct 7 RRLRADAQRNVDRIVAAAQEVFRRDGAGASLEEIARRAGVGSATLHRHFPGRQALLESVF 66 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALA----------GVG 115 DR+ + + PGDAL A+LR V ++ +T RGLV AL G G Sbjct 67 RDRLEALCARADEHAAGLAPGDALLAWLRDFV-EYASTSRGLVAALLPEPEDCGRQDGCG 125 Query 116 IEISSAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAE--LA 173 I+SA L LLR A+ AG VR V +V ++ G + + A Sbjct 126 GRITSA-----------LEGLLRRAREAGAVRDGVRGDDVLAMVNGISLVTELRGDDGQA 174 Query 174 AKVTDVALDGLRANR 188 ++ D+A+DG+R R Sbjct 175 ERLLDLAIDGMRGGR 189 >gi|111223256|ref|YP_714050.1| TetR family transcriptional regulator [Frankia alni ACN14a] gi|111150788|emb|CAJ62492.1| putative TetR family transcriptional regulator [Frankia alni ACN14a] Length=197 Score = 104 bits (259), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 71/182 (40%), Positives = 99/182 (55%), Gaps = 3/182 (1%) Query 6 RRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVI 65 R +RADA RNR +VL+ A + F+A G VP++ +AR AGVG T+YRHFPT+E L +AV Sbjct 8 RPLRADARRNRDQVLDAALRAFSAGGPGVPLEAVARDAGVGIATLYRHFPTREVLVEAVY 67 Query 66 ADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEA 125 + R+ D ALL P AL A++ + L + RG+ +AL V Sbjct 68 RAELGRLCDAAPALLGRLPPAAALRAWMDAF-LDYTTAKRGMADALRAVIASGGDPFAHT 126 Query 126 EADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGCQAMQSYNAE--LAAKVTDVALDG 183 + +T LL A AGTVR DVD ++V T L G A+ A ++ D+ +DG Sbjct 127 RKRMVAAVTSLLAAGDAAGTVRADVDPVDVLTGLAGVTLAAGEPAQRAQAGRLLDLFMDG 186 Query 184 LR 185 LR Sbjct 187 LR 188 >gi|111221504|ref|YP_712298.1| TetR family transcriptional regulator [Frankia alni ACN14a] gi|111149036|emb|CAJ60718.1| Putative TetR family transcriptional regulator [Frankia alni ACN14a] Length=194 Score = 103 bits (258), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 73/188 (39%), Positives = 101/188 (54%), Gaps = 9/188 (4%) Query 2 APTDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALF 61 AP R RADA RNR +L A F G + EIARRAGVG GT+YRHFPT+ L Sbjct 8 APGQRPPRADARRNRELLLAAARTAFEEAGPDTSLVEIARRAGVGQGTLYRHFPTRADLL 67 Query 62 QAVIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGI--EIS 119 QAV+ADR+ + + L ++ P AL A+LR ++ + LAG + EI Sbjct 68 QAVLADRIETLCRRAAQLSAAESPDGALAAWLRLFLVHVHGN-----QGLAGAFMVEEIE 122 Query 120 SAAPEAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC--QAMQSYNAELAAKVT 177 + ++ DLLR AQR GT RPD+ ++ L+VG +S NA+ A ++ Sbjct 123 PWVADCHRVIVEAAADLLRRAQRTGTARPDLTPDDLVQLVVGIALATARSDNADQADRLL 182 Query 178 DVALDGLR 185 +ALD +R Sbjct 183 TLALDAVR 190 >gi|302539770|ref|ZP_07292112.1| TetR family transcriptional regulator [Streptomyces hygroscopicus ATCC 53653] gi|302457388|gb|EFL20481.1| TetR family transcriptional regulator [Streptomyces himastatinicus ATCC 53653] Length=187 Score = 102 bits (254), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 73/188 (39%), Positives = 102/188 (55%), Gaps = 10/188 (5%) Query 4 TDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQA 63 T RR R+DA +NR R+LEVA Q FA GL IA++AGVG GT+YRHFPT+EAL A Sbjct 4 TPRRTRSDALQNRERLLEVAVQVFAQQGLDTAPAAIAKQAGVGVGTLYRHFPTREALIDA 63 Query 64 VIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAP 123 R+ R+ ++ LL ++HP + + G+ EAL V I+S Sbjct 64 AYRHRLTRVCEEAADLL-TRHPAAEATRMWMEHFIDYATAKSGMSEALNAV---IASGV- 118 Query 124 EAEADFLDLLTD----LLRAAQRAGTVRPDVDVLEVKTLLVG-CQAMQSYNAELAAKVTD 178 + AD LLTD LL A R G++R DV +V L+ G ++Q AE A ++ D Sbjct 119 DPYADSRALLTDAVAALLDAGARDGSLRSDVTSDDVLLLMGGIAYSVQHSTAEQARRLVD 178 Query 179 VALDGLRA 186 + +D + A Sbjct 179 LLMDAMTA 186 >gi|217979434|ref|YP_002363581.1| TetR family transcriptional regulator [Methylocella silvestris BL2] gi|217504810|gb|ACK52219.1| transcriptional regulator, TetR family [Methylocella silvestris BL2] Length=209 Score = 102 bits (253), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 68/188 (37%), Positives = 107/188 (57%), Gaps = 5/188 (2%) Query 4 TDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQA 63 + R+ RADA RN R++E+A FA G+ V +DEIARRAGVG GT+YRHFP ++A+ +A Sbjct 23 SPRKPRADAKRNHERLVEMAKAAFADVGVDVGLDEIARRAGVGIGTLYRHFPNRDAIVEA 82 Query 64 VIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAP 123 V + ++ D +LL+S PG+AL ++R + + + AT + + AL + S Sbjct 83 VYRREVQQLADSAASLLQSLSPGEALREWMR-LFVDYIATKKVIAPALGSIVGGASELYA 141 Query 124 EAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC---QAMQSYNAELAAKVTDVA 180 + A ++ L+ A +G +R DVD ++ LVG A + A A ++ D+ Sbjct 142 SSGARITAAMSLLVERAGASGDIRADVDPNDLLRALVGFTYGNAAPGWEAS-ARRLIDIL 200 Query 181 LDGLRANR 188 +DGLR R Sbjct 201 MDGLRPPR 208 >gi|345002575|ref|YP_004805429.1| TetR family transcriptional regulator [Streptomyces sp. SirexAA-E] gi|344318201|gb|AEN12889.1| transcriptional regulator, TetR family [Streptomyces sp. SirexAA-E] Length=207 Score = 102 bits (253), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 69/184 (38%), Positives = 96/184 (53%), Gaps = 3/184 (1%) Query 4 TDRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQA 63 T R R DA RNR R+L VA FAA G P+D IAR AGVG GT+YRHFPT+EAL +A Sbjct 16 TGRPTRVDARRNRERLLAVARDAFAATGGKAPLDAIAREAGVGIGTLYRHFPTREALVEA 75 Query 64 VIADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAP 123 + A + ++ ALL P AL A++ + A RG+ + L + A P Sbjct 76 IYASELDAVVTSAPALLSQFPPEAALRAWMDRYAAFFAA-KRGISDTLRAGWASGAIATP 134 Query 124 EAEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC--QAMQSYNAELAAKVTDVAL 181 + +L A RAG++R DV+ EV +L+G + EL ++ D+ + Sbjct 135 ATRERITAAIAVILDAGVRAGSLRADVEPDEVTMMLLGVFLSTTAGDSHELTGRLLDLVV 194 Query 182 DGLR 185 D LR Sbjct 195 DALR 198 >gi|328884637|emb|CCA57876.1| Transcriptional regulator, TetR family [Streptomyces venezuelae ATCC 10712] Length=181 Score = 102 bits (253), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 67/181 (38%), Positives = 97/181 (54%), Gaps = 4/181 (2%) Query 8 VRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIAD 67 +RADA RN R+L A TFAA G P++EIARRAGVG GT+YRHFPT+ L AV + Sbjct 1 MRADARRNHERLLTEARATFAAQGADAPLEEIARRAGVGIGTLYRHFPTRAELLNAVFQE 60 Query 68 RMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEA 127 + ++D+ L ++ P AL +LR++V G RGL AL + SSA + Sbjct 61 ALTELLDRSGELAEAAEPCRALVEWLRALVAHAGEY-RGLAHALMSASYDRSSALAQCSE 119 Query 128 DFLDLLTDLLRAAQRAGTVRPDV---DVLEVKTLLVGCQAMQSYNAELAAKVTDVALDGL 184 LL A+ AG VR DV D++++ + + ELA ++ + L G+ Sbjct 120 PLRAAGERLLGRAREAGQVRADVSIGDLMQLTNAIALAAEQCPEDEELADRLLALTLRGI 179 Query 185 R 185 + Sbjct 180 K 180 >gi|300784394|ref|YP_003764685.1| TetR family transcriptional regulator [Amycolatopsis mediterranei U32] gi|299793908|gb|ADJ44283.1| TetR family transcriptional regulator [Amycolatopsis mediterranei U32] gi|340525815|gb|AEK41020.1| TetR family transcriptional regulator [Amycolatopsis mediterranei S699] Length=187 Score = 101 bits (252), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 70/183 (39%), Positives = 99/183 (55%), Gaps = 2/183 (1%) Query 5 DRRVRADAARNRARVLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAV 64 +R +RADA RN R++ A F A G VP+D++A++AGVGAGT+YRHFPT+E LF+AV Sbjct 6 ERPMRADARRNYERIVATAKDLFTAHGADVPLDDVAKKAGVGAGTLYRHFPTREKLFEAV 65 Query 65 IADRMHRIIDKGHALLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPE 124 D + + D+ L P +AL A+L + V W L L S Sbjct 66 YRDEITVLADRAFVLHDELPPWEALKAWLLAQV-TWVVERHKLATILKESIDSGSETFQY 124 Query 125 AEADFLDLLTDLLRAAQRAGTVRPDVDVLEVKTLLVGC-QAMQSYNAELAAKVTDVALDG 183 + + L+ AAQ AG VRPDV +V L G A+++ + + +V +V LDG Sbjct 125 CQKRLREATGVLVEAAQEAGLVRPDVVGADVLRLGHGAGMAVRNCSPDDGKRVLNVILDG 184 Query 184 LRA 186 LRA Sbjct 185 LRA 187 >gi|288920689|ref|ZP_06414991.1| transcriptional regulator, TetR family [Frankia sp. EUN1f] gi|288347886|gb|EFC82161.1| transcriptional regulator, TetR family [Frankia sp. EUN1f] Length=202 Score = 101 bits (252), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 67/170 (40%), Positives = 91/170 (54%), Gaps = 6/170 (3%) Query 19 VLEVAYQTFAADGLSVPVDEIARRAGVGAGTVYRHFPTKEALFQAVIADRMHRIIDKGHA 78 +LE A FA G S +E+ARRAGV GTV+RHFPTKEAL A++ D + R+ D+ Sbjct 31 ILEAAEAVFAEKGASASTEEVARRAGVAIGTVFRHFPTKEALLGALVGDLVERLGDEVQV 90 Query 79 LLKSKHPGDALFAFLRSMVLQWGATDRGLVEALAGVGIEISSAAPEAEADFLDLLTDLLR 138 L+ P +LF F MV Q A + +V+ LA GI++ A P + LL Sbjct 91 LVAEGDPATSLFTFFTGMVEQ-AAAKKTVVDLLATSGIDLPVAKPVHA--LRQPIEALLT 147 Query 139 AAQRAGTVRPDVDVLEVKTLLVG-CQAM--QSYNAELAAKVTDVALDGLR 185 +Q+ G VR DV + EV LL CQA ++ +L + V DGLR Sbjct 148 RSQQVGAVRADVRIPEVLALLTAVCQAALRGDWDQDLRTRTLTVVFDGLR 197 Lambda K H 0.322 0.135 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 187037746340 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40