BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0213c Length=437 Score E Sequences producing significant alignments: (Bits) Value gi|339293277|gb|AEJ45388.1| methyltransferase/methylase [Mycobac... 895 0.0 gi|167968789|ref|ZP_02551066.1| hypothetical methyltransferase [... 895 0.0 gi|339296923|gb|AEJ49033.1| methyltransferase/methylase [Mycobac... 894 0.0 gi|15607354|ref|NP_214727.1| methyltransferase (methylase) [Myco... 894 0.0 gi|326905968|gb|EGE52901.1| methyltransferase/methylase [Mycobac... 892 0.0 gi|308231494|ref|ZP_07412640.2| methyltransferase/methylase [Myc... 892 0.0 gi|289441589|ref|ZP_06431333.1| methyltransferase/methylase [Myc... 891 0.0 gi|240172375|ref|ZP_04751034.1| putative methyltransferase [Myco... 729 0.0 gi|183981707|ref|YP_001849998.1| methyltransferase [Mycobacteriu... 711 0.0 gi|240170544|ref|ZP_04749203.1| methyltransferase [Mycobacterium... 697 0.0 gi|304315672|ref|YP_003850817.1| radical SAM protein [Thermoanae... 182 9e-44 gi|333895984|ref|YP_004469858.1| radical SAM protein [Thermoanae... 181 3e-43 gi|296133827|ref|YP_003641074.1| Radical SAM domain protein [The... 154 3e-35 gi|86749195|ref|YP_485691.1| radical SAM binding protein [Rhodop... 153 7e-35 gi|157364568|ref|YP_001471335.1| radical SAM domain-containing p... 152 2e-34 gi|312137248|ref|YP_004004585.1| radical sam domain protein [Met... 145 1e-32 gi|222100769|ref|YP_002535337.1| Radical SAM domain protein [The... 142 1e-31 gi|325959709|ref|YP_004291175.1| Radical SAM domain-containing p... 141 2e-31 gi|197119669|ref|YP_002140096.1| radical SAM protein with cobala... 141 2e-31 gi|159149048|dbj|BAF92596.1| methyltransferase [Streptomyces pac... 138 2e-30 gi|326200980|ref|ZP_08190852.1| cobalamin B12-binding domain pro... 137 4e-30 gi|148642445|ref|YP_001272958.1| anaerobic magnesium-protoporphy... 136 6e-30 gi|253699579|ref|YP_003020768.1| radical SAM protein [Geobacter ... 136 6e-30 gi|222446056|ref|ZP_03608571.1| hypothetical protein METSMIALI_0... 136 8e-30 gi|332159332|ref|YP_004424611.1| methyltransferase [Pyrococcus s... 132 9e-29 gi|325959575|ref|YP_004291041.1| Radical SAM domain-containing p... 132 1e-28 gi|333987982|ref|YP_004520589.1| Radical SAM domain-containing p... 131 3e-28 gi|94969363|ref|YP_591411.1| radical SAM family Fe-S protein [Ca... 130 3e-28 gi|78222914|ref|YP_384661.1| cobalamin B12-binding/radical SAM f... 130 4e-28 gi|222100094|ref|YP_002534662.1| Mg-protoporphyrin IX monomethyl... 130 6e-28 gi|159149049|dbj|BAF92597.1| methyltransferase [Streptomyces pac... 129 8e-28 gi|242399824|ref|YP_002995249.1| Fe-S oxidoreductase [Thermococc... 129 8e-28 gi|239907228|ref|YP_002953969.1| hypothetical protein DMR_25920 ... 129 1e-27 gi|220929791|ref|YP_002506700.1| cobalamin B12-binding domain-co... 128 2e-27 gi|298529538|ref|ZP_07016941.1| Radical SAM domain protein [Desu... 127 3e-27 gi|157364573|ref|YP_001471340.1| radical SAM domain-containing p... 127 5e-27 gi|325968646|ref|YP_004244838.1| radical SAM protein [Vulcanisae... 125 1e-26 gi|218782942|ref|YP_002434260.1| radical SAM domain-containing p... 125 1e-26 gi|218777948|ref|YP_002429266.1| radical SAM domain-containing p... 125 1e-26 gi|14590686|ref|NP_142754.1| methyltransferase [Pyrococcus horik... 125 2e-26 gi|170288989|ref|YP_001739227.1| cobalamin B12-binding domain-co... 124 3e-26 gi|325958322|ref|YP_004289788.1| Radical SAM domain-containing p... 124 4e-26 gi|326391529|ref|ZP_08213061.1| Radical SAM domain protein [Ther... 124 4e-26 gi|326201007|ref|ZP_08190879.1| cobalamin B12-binding domain pro... 123 5e-26 gi|333986756|ref|YP_004519363.1| Radical SAM domain-containing p... 123 5e-26 gi|148270385|ref|YP_001244845.1| radical SAM domain-containing p... 123 7e-26 gi|219851304|ref|YP_002465736.1| Radical SAM domain protein [Met... 123 7e-26 gi|144897660|emb|CAM74524.1| Coenzyme B12-binding:Radical SAM [M... 122 9e-26 gi|308275233|emb|CBX31830.1| hypothetical protein N47_N26550 [un... 122 9e-26 gi|344925566|ref|ZP_08779027.1| radical SAM protein [Candidatus ... 122 1e-25 >gi|339293277|gb|AEJ45388.1| methyltransferase/methylase [Mycobacterium tuberculosis CCDC5079] Length=438 Score = 895 bits (2312), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/437 (100%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 2 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 61 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 62 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 121 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 122 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 181 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 182 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 241 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 242 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 301 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY Sbjct 302 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 361 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR Sbjct 362 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 421 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 422 LDEWENVIAGRIAEATS 438 >gi|167968789|ref|ZP_02551066.1| hypothetical methyltransferase [Mycobacterium tuberculosis H37Ra] gi|253797135|ref|YP_003030136.1| methyltransferase/methylase [Mycobacterium tuberculosis KZN 1435] gi|254366662|ref|ZP_04982706.1| hypothetical methyltransferase (methylase) [Mycobacterium tuberculosis str. Haarlem] gi|308394871|ref|ZP_07491803.2| methyltransferase/methylase [Mycobacterium tuberculosis SUMu012] gi|134152174|gb|EBA44219.1| hypothetical methyltransferase (methylase) [Mycobacterium tuberculosis str. Haarlem] gi|253318638|gb|ACT23241.1| methyltransferase/methylase [Mycobacterium tuberculosis KZN 1435] gi|308367561|gb|EFP56412.1| methyltransferase/methylase [Mycobacterium tuberculosis SUMu012] gi|323717202|gb|EGB26411.1| methyltransferase/methylase [Mycobacterium tuberculosis CDC1551A] Length=443 Score = 895 bits (2312), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/437 (100%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 7 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 66 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 67 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 126 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 127 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 186 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 187 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 246 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 247 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 306 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY Sbjct 307 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 366 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR Sbjct 367 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 426 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 427 LDEWENVIAGRIAEATS 443 >gi|339296923|gb|AEJ49033.1| methyltransferase/methylase [Mycobacterium tuberculosis CCDC5180] Length=445 Score = 894 bits (2311), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/437 (100%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 9 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 68 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 69 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 128 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 129 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 188 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 189 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 248 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 249 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 308 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY Sbjct 309 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 368 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR Sbjct 369 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 428 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 429 LDEWENVIAGRIAEATS 445 >gi|15607354|ref|NP_214727.1| methyltransferase (methylase) [Mycobacterium tuberculosis H37Rv] gi|15839593|ref|NP_334630.1| methyltransferase, putative [Mycobacterium tuberculosis CDC1551] gi|31791391|ref|NP_853884.1| methyltransferase (methylase) [Mycobacterium bovis AF2122/97] 39 more sequence titles Length=437 Score = 894 bits (2310), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/437 (100%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY Sbjct 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR Sbjct 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 421 LDEWENVIAGRIAEATS 437 >gi|326905968|gb|EGE52901.1| methyltransferase/methylase [Mycobacterium tuberculosis W-148] Length=437 Score = 892 bits (2305), Expect = 0.0, Method: Compositional matrix adjust. Identities = 436/437 (99%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY Sbjct 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEA+FLSR Sbjct 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAHFLSR 420 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 421 LDEWENVIAGRIAEATS 437 >gi|308231494|ref|ZP_07412640.2| methyltransferase/methylase [Mycobacterium tuberculosis SUMu001] gi|308369334|ref|ZP_07417383.2| methyltransferase/methylase [Mycobacterium tuberculosis SUMu002] gi|308370345|ref|ZP_07421156.2| methyltransferase/methylase [Mycobacterium tuberculosis SUMu003] 19 more sequence titles Length=477 Score = 892 bits (2304), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/437 (100%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 41 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 100 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 101 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 160 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 161 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 220 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 221 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 280 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 281 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 340 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY Sbjct 341 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 400 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR Sbjct 401 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 460 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 461 LDEWENVIAGRIAEATS 477 >gi|289441589|ref|ZP_06431333.1| methyltransferase/methylase [Mycobacterium tuberculosis T46] gi|289568116|ref|ZP_06448343.1| methyltransferase/methylase [Mycobacterium tuberculosis T17] gi|289748689|ref|ZP_06508067.1| methyltransferase/methylase [Mycobacterium tuberculosis T92] gi|289756278|ref|ZP_06515656.1| methyltransferase [Mycobacterium tuberculosis EAS054] gi|289414508|gb|EFD11748.1| methyltransferase/methylase [Mycobacterium tuberculosis T46] gi|289541869|gb|EFD45518.1| methyltransferase/methylase [Mycobacterium tuberculosis T17] gi|289689276|gb|EFD56705.1| methyltransferase/methylase [Mycobacterium tuberculosis T92] gi|289696865|gb|EFD64294.1| methyltransferase [Mycobacterium tuberculosis EAS054] Length=437 Score = 891 bits (2302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 436/437 (99%), Positives = 436/437 (99%), Gaps = 0/437 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW Sbjct 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV Sbjct 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF Sbjct 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF Sbjct 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT Sbjct 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTV FKFMSRIVPY Sbjct 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVCFKFMSRIVPY 360 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR Sbjct 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 Query 421 LDEWENVIAGRIAEATS 437 LDEWENVIAGRIAEATS Sbjct 421 LDEWENVIAGRIAEATS 437 >gi|240172375|ref|ZP_04751034.1| putative methyltransferase [Mycobacterium kansasii ATCC 12478] Length=433 Score = 729 bits (1882), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/433 (80%), Positives = 394/433 (91%), Gaps = 0/433 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAK +G+ V +VNGLVAGH V++TW AMQ+AA +SG PRLVGFSCIDTF EVLW Sbjct 1 MSIKAYAKARGLEVATVNGLVAGHECVEQTWQAMQAAATVSGVPRLVGFSCIDTFAEVLW 60 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LA+RARQ W+GV+I +GN +ATLNYERIL ++DCFD+VVVGDGEV FT+LALA+AN A V Sbjct 61 LARRARQCWEGVQIALGNVIATLNYERILGEYDCFDFVVVGDGEVTFTELALAVANGAGV 120 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 + +PGLARR EQG+I+ +PS LVDLDELP PAR+ELPTVL DGFAASVF+TRGCPYRCTF Sbjct 121 EGIPGLARRDEQGRIVCSPSGLVDLDELPWPAREELPTVLGDGFAASVFTTRGCPYRCTF 180 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGA+SAMLG+ SYR KSVDAVVDEI YLVSD+D+ FLSITDDLF+SKHPGSQQRA +F Sbjct 181 CGTGAVSAMLGRTSYRVKSVDAVVDEIAYLVSDFDIQFLSITDDLFVSKHPGSQQRAVEF 240 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 A+A+L RGI VNFM+DIRLDSVVDLDLFKHLHRAGLRRVF+G+ETGSY+QLRAYRKQIL+ Sbjct 241 ASAMLGRGIDVNFMIDIRLDSVVDLDLFKHLHRAGLRRVFVGLETGSYDQLRAYRKQILS 300 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQLGIDVIPGTIMFHPTV+P+ELRET RLLRATKYT FKFM RI PY Sbjct 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVRPEELRETARLLRATKYTQPFKFMGRITPY 360 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYS+AGYL+A+WPLGQW+FVDPEA+RVYADVVA++APD I+FDEAEA+FL+R Sbjct 361 PGTPLYQAYSEAGYLSAEWPLGQWDFVDPEAARVYADVVARIAPDEDITFDEAEAFFLAR 420 Query 421 LDEWENVIAGRIA 433 LDEW+N A +IA Sbjct 421 LDEWDNATARQIA 433 >gi|183981707|ref|YP_001849998.1| methyltransferase [Mycobacterium marinum M] gi|183175033|gb|ACC40143.1| methyltransferase [Mycobacterium marinum M] Length=498 Score = 711 bits (1835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/431 (77%), Positives = 383/431 (89%), Gaps = 0/431 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYAKTQGI + +VNGLVAGH SVQETW A+++A SG PRLVGFSCIDT PEVLW Sbjct 41 MSIKAYAKTQGIEIATVNGLVAGHSSVQETWSAIENAVRCSGKPRLVGFSCIDTLPEVLW 100 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQR R+ WD V+I +GNA+ATLNYERILRQHDCFD+V+VGD EV FTKLA A+AN AA+ Sbjct 101 LAQRVRETWDDVQIALGNAIATLNYERILRQHDCFDFVIVGDAEVGFTKLANAVANGAAL 160 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DDVPGLARR ++GQI+ +PS L+DLDELPRPARDELP+VLADGF+A+VFSTRGCPYRCTF Sbjct 161 DDVPGLARRDDRGQIICSPSRLIDLDELPRPARDELPSVLADGFSAAVFSTRGCPYRCTF 220 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSAMLG++SYRAKSVDAVVDEI YL SD+D+ FL ITDDLFISKHP SQQRAA+F Sbjct 221 CGTGAMSAMLGRNSYRAKSVDAVVDEIAYLKSDFDIGFLCITDDLFISKHPSSQQRAAEF 280 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 A+A++ G+ V FM+DIRLDSVVDL+LFKHLH+AGLRRVF+G+ETGSY+QLRAYRKQI+ Sbjct 281 ADAMINSGVDVKFMMDIRLDSVVDLELFKHLHKAGLRRVFVGLETGSYDQLRAYRKQIIN 340 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQDAADTINALQQ+G+DVIPGTIMFHPTVQPDELRET RLLRATK+ +KFM +I PY Sbjct 341 RGQDAADTINALQQVGVDVIPGTIMFHPTVQPDELRETARLLRATKFISTYKFMGKITPY 400 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQ YSD GYL +WPLG+W+FVDPEA+RVYADV + +AP + +DEAE +FL+R Sbjct 401 PGTPLYQEYSDLGYLREEWPLGEWDFVDPEAARVYADVCSLIAPRPDLPYDEAEKFFLAR 460 Query 421 LDEWENVIAGR 431 LDEW++VIA R Sbjct 461 LDEWDDVIAAR 471 >gi|240170544|ref|ZP_04749203.1| methyltransferase [Mycobacterium kansasii ATCC 12478] Length=442 Score = 697 bits (1799), Expect = 0.0, Method: Compositional matrix adjust. Identities = 323/426 (76%), Positives = 384/426 (91%), Gaps = 0/426 (0%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW 60 MSIKAYA +QG+ + +VNGLVAGH V++TW AM+ A ++GTP LVG SCIDTF EVLW Sbjct 7 MSIKAYAASQGLDIATVNGLVAGHVGVEQTWQAMRDVARVAGTPGLVGLSCIDTFAEVLW 66 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 LAQRAR++W GV+I +GN +ATLNYERILRQ+DCFD+VVVGDGEV FT+LALA+AN + Sbjct 67 LAQRARESWPGVQIALGNVIATLNYERILRQYDCFDFVVVGDGEVGFTQLALAVANGDEI 126 Query 121 DDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTF 180 DVPG+ARR +GQI+ +PS+LVDLD LPR AR+ELPTVLADGF+A+VF+TRGCPYRCTF Sbjct 127 ADVPGVARRDARGQIVCSPSTLVDLDRLPRAAREELPTVLADGFSAAVFTTRGCPYRCTF 186 Query 181 CGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADF 240 CGTGAMSA+LG++SYRAKSVD+VVDEI YLVSD+D+NF+SITDDLF+SKHPGSQQRA +F Sbjct 187 CGTGAMSAILGRNSYRAKSVDSVVDEITYLVSDFDINFVSITDDLFVSKHPGSQQRAVEF 246 Query 241 ANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILT 300 A+A+LRRGI VNFMVDIRLDSVVDLD+F+HLH+AGLRRVF+G+ETGSYEQLRAYRKQI+ Sbjct 247 ASAILRRGIDVNFMVDIRLDSVVDLDVFRHLHQAGLRRVFVGIETGSYEQLRAYRKQIIN 306 Query 301 RGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPY 360 RGQD A+TINAL +LGIDVIPGTIMFHPTV+P+ELRET RLLRAT+Y FKF+S+I PY Sbjct 307 RGQDPAETINALLRLGIDVIPGTIMFHPTVRPEELRETARLLRATRYRHPFKFLSKITPY 366 Query 361 PGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSR 420 PGTPLYQAYS AGYLT +WPLGQWEF DPEA+RVYAD+VA++A D I+FDEAEA+FL+R Sbjct 367 PGTPLYQAYSAAGYLTDEWPLGQWEFADPEAARVYADLVARIASDAEITFDEAEAFFLAR 426 Query 421 LDEWEN 426 LDEW+N Sbjct 427 LDEWDN 432 >gi|304315672|ref|YP_003850817.1| radical SAM protein [Thermoanaerobacterium thermosaccharolyticum DSM 571] gi|302777174|gb|ADL67733.1| Radical SAM domain protein [Thermoanaerobacterium thermosaccharolyticum DSM 571] Length=448 Score = 182 bits (462), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 116/363 (32%), Positives = 181/363 (50%), Gaps = 12/363 (3%) Query 41 SGTPRLVGFSC--IDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYV 98 S P+L+G S D+ E L + R+A I IG T +Y+ IL D V Sbjct 60 SDKPKLIGVSIPFQDSASEALEFVKSIREAGYKGHISIGGIYPTFSYDEILSVCPQIDTV 119 Query 99 VVGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVD-LDELPRPARDELP 157 VVG+GE+ F +LA + +D ++ G+A R + L L+D LD +P P RD LP Sbjct 120 VVGEGEITFLELARKVLSDEDWKNISGIAYRDDGTLRLNDKRPLIDDLDSMPYPERDTLP 179 Query 158 TVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVN 217 V+ AS+ ++RGC RC+FC G + G+ YR +SV+ V+DEI L Y+V Sbjct 180 IVILKSGFASMLTSRGCYGRCSFCSVGPFFSQFGQ-KYRQRSVENVIDEIRILYEKYNVR 238 Query 218 FLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLR 277 L D FI + +R A +++RG+ +NF + R++ VD +LF L +AGL+ Sbjct 239 NLFFNDAEFIGGKGKNYERVYKLAEEIIKRGMDINFSIQCRVND-VDKELFSILKKAGLK 297 Query 278 RVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRE 337 RVF+GVE+GS L ++K + + +D + L L + + G IMF P + EL E Sbjct 298 RVFLGVESGSQTVLDRFKKDV--KVEDNIKALKILNDLDLYISMGFIMFDPHINFKELSE 355 Query 338 TVRLLRATKYTVG-----FKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEAS 392 + + +G + +SR++P GT + + + G +EF D Sbjct 356 NISFINNAVKLIGKERLDYYPVSRLLPLAGTEVERDMKEKGLYKGNSLNYNYEFDDKTIG 415 Query 393 RVY 395 +Y Sbjct 416 FIY 418 >gi|333895984|ref|YP_004469858.1| radical SAM protein [Thermoanaerobacterium xylanolyticum LX-11] gi|333111249|gb|AEF16186.1| Radical SAM domain protein [Thermoanaerobacterium xylanolyticum LX-11] Length=466 Score = 181 bits (458), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 113/364 (32%), Positives = 182/364 (50%), Gaps = 16/364 (4%) Query 42 GTPRLVGFSC--IDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVV 99 P+L+G S D E L ++ ++ + +G T +Y+ IL + D VV Sbjct 80 NKPKLIGVSIPFQDGAIEALRFIKKIKETGYKGHLSVGGIYPTFSYDEILMECPQIDTVV 139 Query 100 VGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSS---LVDLDELPRPARDEL 156 +G+GE+ FT+LA + ND D+ G+ + G L+ + DLD +P P RD L Sbjct 140 LGEGELTFTELAKKILNDEEWKDLEGIVYKD--GDTLKANDKRPLIDDLDSMPYPERDTL 197 Query 157 PTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDV 216 P V+ AS+ ++RGC RC+FC G + G+ YR +SV+ V+DEI L Y+V Sbjct 198 PIVILKSGFASILTSRGCYGRCSFCSVGPFFSQFGQ-KYRQRSVENVIDEIKILYEKYNV 256 Query 217 NFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGL 276 L D F+ S +RA A ++R G+++NF + R++ VD +LF L +AGL Sbjct 257 RNLFFNDAEFVGGKGKSYERAYRLAEEIIRSGMNINFSIQCRVND-VDKELFSILKKAGL 315 Query 277 RRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELR 336 +RVF+GVE+GS L ++K + R +D + + L L + + G IMF P + EL Sbjct 316 KRVFLGVESGSQTVLDRFKKDV--RVEDNINALKILNDLDLYISMGFIMFDPHINFKELS 373 Query 337 ETVRLLRATKYTVG-----FKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEA 391 E + + +G + +SR++P GT + + + G +EF D Sbjct 374 ENISFINNAVKLIGKERLDYYPVSRLLPLAGTEVERDMKEKGLYKGNSLNYNYEFDDKTI 433 Query 392 SRVY 395 +Y Sbjct 434 GFIY 437 >gi|296133827|ref|YP_003641074.1| Radical SAM domain protein [Thermincola sp. JR] gi|296032405|gb|ADG83173.1| Radical SAM domain protein [Thermincola potens JR] Length=445 Score = 154 bits (389), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 99/300 (33%), Positives = 148/300 (50%), Gaps = 10/300 (3%) Query 74 IVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAVDDVPGLARRSEQG 133 I IG T YE I+ D VV+G+GE F +LA + + + G+A R Sbjct 92 ITIGGIYPTFCYEEIMHMFPAIDSVVLGEGEHTFVELAKTVLHGRDWRKIRGIAYRENDK 151 Query 134 QILRTPSSLV-DLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGK 192 + P +L+ DLD LP PARD LP VL A++ S+RGC RC+FC + G Sbjct 152 IVTNEPRALIKDLDSLPFPARDSLPEVLKRLGFATMLSSRGCYGRCSFCSVIPFYSKFGP 211 Query 193 DSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVN 252 YR +S + V++EID L ++Y V + D F+ RA + A +L+R + + Sbjct 212 -KYRLRSSENVMEEIDVLYNEYGVRNIEFNDANFVGGKGHGFHRAREIAEEILKRNLDLR 270 Query 253 FMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINAL 312 + R D VD +LF L RAGL +VF+GVE+GS L ++K I ++ + L Sbjct 271 LSIQCRPDD-VDEELFAILKRAGLSKVFLGVESGSQTMLDRFKKDITV--EENIKALEIL 327 Query 313 QQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYT-----VGFKFMSRIVPYPGTPLYQ 367 +L VI G I F + E RE + ++ T + F S+++P GT + Q Sbjct 328 GRLDFIVIMGFITFDDRITIREFRENMAFIKKATRTMPISKLKFNLASKLIPLAGTEVEQ 387 >gi|86749195|ref|YP_485691.1| radical SAM binding protein [Rhodopseudomonas palustris HaA2] gi|86572223|gb|ABD06780.1| Radical SAM binding protein [Rhodopseudomonas palustris HaA2] Length=598 Score = 153 bits (386), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 105/302 (35%), Positives = 159/302 (53%), Gaps = 10/302 (3%) Query 44 PRLVGFSCID--TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 PR+VG S + L LA+R + A G+ IV+G +AT + +L DYVV G Sbjct 98 PRIVGLSVLYDLQLGNALVLARRLKAARPGLAIVLGGPLATALSQELLGTFAFVDYVVEG 157 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTP-SSLVDLDELPRPARDELPTVL 160 +GE A ++LA A+ A DVP LA R G I+R P + +DLD LP PARD L ++ Sbjct 158 EGEAALSRLADAIERGEAPSDVPALAHRGPGG-IVRNPRGAPLDLDRLPHPARDGLASIR 216 Query 161 ADGF---AASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVN 217 A G +A + ++RGC CTFC L YR + VVDEI+ LV D+ V+ Sbjct 217 ARGLPAPSAYLTTSRGCKAFCTFCTVPGSVRSLKSGVYRMRDPVDVVDEIEELVRDHGVS 276 Query 218 FLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLR 277 + DD F+ S R FA+ +LRR ++++F + R+DS++ L + L AG Sbjct 277 RFYMADDNFLGYGEDSNARMHRFADEILRRRLAIHFHAECRVDSLIPETLVR-LRAAGFD 335 Query 278 RVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRE 337 ++ G+E+GS L+ + K +AA I ++L I+++P I+ E+ E Sbjct 336 QILFGLESGSARTLKRWAKGQTVAQNEAA--IALARRLRIEMMPSLILLDWESDLSEIEE 393 Query 338 TV 339 T+ Sbjct 394 TI 395 >gi|157364568|ref|YP_001471335.1| radical SAM domain-containing protein [Thermotoga lettingae TMO] gi|157315172|gb|ABV34271.1| Radical SAM domain protein [Thermotoga lettingae TMO] Length=439 Score = 152 bits (383), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 105/347 (31%), Positives = 169/347 (49%), Gaps = 23/347 (6%) Query 26 SVQETWLAMQSAAALSGTPRLVGFSC--IDTFPEVLWLAQRARQAWDGVRIVIGNAMATL 83 SV++T ++S A P+++G S D E + + ++A I +G T Sbjct 45 SVKKTLEKIKSFA-----PQIIGISIPFQDYTLETMNFVKLVKKASPKSHITVGGIFPTF 99 Query 84 NYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTP-SSL 142 Y +L D +++G+GE F A A N ++ G+A + + G+IL+ P + Sbjct 100 AYYTLLENFSAIDSIILGEGETGFINFARAFLNGKNWQNINGIAYK-KNGEILKNPFNKA 158 Query 143 VDLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDA 202 +LD+L PARD LP L AS+ S+RGC RC FC + GK R +SV+ Sbjct 159 ANLDDLSFPARDFLPDALKKVGYASMESSRGCYGRCIFCSVVPFFQLSGK-KLRFRSVEN 217 Query 203 VVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSV 262 VV+EI L ++ V ++S D F++ S++RA A +++ + + + ++ R D + Sbjct 218 VVEEIKILKKNHGVKYISFNDANFLA----SKERAFLLAERIIKENLDIRYSIECRADDI 273 Query 263 VDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPG 322 + DL + L +GLR+VF+G+E+G L ++K T QD L + I + G Sbjct 274 NE-DLLRLLKESGLRKVFLGIESGVQSVLDRFKKD--TTVQDNIKAFEILGKFDIQIRVG 330 Query 323 TIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIV------PYPGT 363 IMF +EL E +R + V K M RIV P GT Sbjct 331 FIMFDELTTLEELSENFNFIRKVRKLVSKKQMKRIVVTSRLLPLAGT 377 >gi|312137248|ref|YP_004004585.1| radical sam domain protein [Methanothermus fervidus DSM 2088] gi|311224967|gb|ADP77823.1| Radical SAM domain protein [Methanothermus fervidus DSM 2088] Length=444 Score = 145 bits (367), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 103/389 (27%), Positives = 186/389 (48%), Gaps = 28/389 (7%) Query 43 TPRLVGFSCIDTF-PEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 P +VG + + L + ++ + VIG AT + LR+ D VV+G Sbjct 37 NPSIVGVTATTPLIKKALEYIKSIKKLLPNILTVIGGPHATFLPIKTLRECPELDVVVIG 96 Query 102 DGEVAFTKLALALANDA--AVDDVPGLARRSEQGQI-LRTPSSLV-DLDELPRPARDELP 157 +GE F +LAL + ++ + G+A R ++ + P L+ +LDE+P PAR +P Sbjct 97 EGEETFKELALEYESKGKKCLEKIRGIAYRDNDERLHINDPRPLIENLDEIPFPARHLVP 156 Query 158 TV---LADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDY 214 L++ + S+RGCPY C +C + S M+GK +R +S + +VDEI+ LV+DY Sbjct 157 FKEYNLSEE-TGGIISSRGCPYNCEYCSS---SKMMGK-RFRYRSAENIVDEIEELVNDY 211 Query 215 DVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRA 274 +V ++ DD F ++R +F N + R + ++F + R+D+ ++ D K+L Sbjct 212 NVREITFLDDTFTI----HRRRIEEFCNELKNRDLDIDFTISSRVDT-INRDTLKNLKTV 266 Query 275 GLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDE 334 GL R++ G E+GS L +K I + D + + L + + + +P DE Sbjct 267 GLNRIYYGAESGSQRVLNLMKKGITLK--QIKDAVKVAKNLNLQTVTSFMFGYPGETLDE 324 Query 335 LRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDP----E 390 + +T+ + K + S + P+PGTP+Y G + W ++ ++P E Sbjct 325 MNKTIDF--SIKLDPDYCQYSILTPFPGTPIYYKLKRKGLINENW--EEYTVLNPVIKYE 380 Query 391 ASRVYADVVAKVAPDVGISFDEAEAYFLS 419 + +V K+ + F +Y + Sbjct 381 KLGLSKKLVKKILEKAYVKFYARPSYLIK 409 >gi|222100769|ref|YP_002535337.1| Radical SAM domain protein [Thermotoga neapolitana DSM 4359] gi|221573159|gb|ACM23971.1| Radical SAM domain protein [Thermotoga neapolitana DSM 4359] Length=325 Score = 142 bits (357), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 96/305 (32%), Positives = 155/305 (51%), Gaps = 16/305 (5%) Query 98 VVVGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPS-SLV-DLDELPRPARDE 155 +V+G+GE+ F +L A+ D + G+A R E+G+I TPS SLV DL+ LP P RD Sbjct 1 MVLGEGEITFYELVKAIFGDKDWRRIHGVAYR-EEGEIKTTPSRSLVKDLNSLPFPVRDN 59 Query 156 LPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYD 215 LP + AASV ++RGC C+FC G R + + VVDE++ LV +Y Sbjct 60 LPRIYEKTGAASVITSRGCYASCSFCSVVPFYEKFG-PKIRLRDPENVVDELEVLVKEYK 118 Query 216 VNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAG 275 + + D F S++RAA A ++RR + + + ++ R+ + VD LF+ L +G Sbjct 119 IENVIFCDANFTI----SKERAAKIATEIIRRKLKLRYAIESRV-TEVDERLFRLLKESG 173 Query 276 LRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDEL 335 LRRVF+G+E+GS L +RK + + + L +L + V PG IMF +EL Sbjct 174 LRRVFLGLESGSQSMLDRFRKGVTV--EQNLKALEILSKLDLYVSPGFIMFDDRTSLEEL 231 Query 336 RETVRLLRATKYTVGFK-----FMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPE 390 +E + L+ + + K ++++P GT + + G ++ DP Sbjct 232 QENAKFLKIVRRIMRDKIRPIDITTKLLPLSGTEFERYLKERGKYRGDVFRFNYKIEDPS 291 Query 391 ASRVY 395 +Y Sbjct 292 VRFIY 296 >gi|325959709|ref|YP_004291175.1| Radical SAM domain-containing protein [Methanobacterium sp. AL-21] gi|325331141|gb|ADZ10203.1| Radical SAM domain protein [Methanobacterium sp. AL-21] Length=476 Score = 141 bits (356), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 102/346 (30%), Positives = 175/346 (51%), Gaps = 24/346 (6%) Query 44 PRLVGFSCI-DTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD 102 P ++G + T L + ++ V VIG T L+ D D VV+G+ Sbjct 65 PEIIGITATTSTIKTALKYLEEIKKVMPHVLTVIGGPHTTFLPVNTLQNSDDLDVVVLGE 124 Query 103 GEVAFTKLALALAN-DAAVDDVPGLARRSEQGQILRT--PSSLV-DLDELPRPARDELPT 158 GE F LA + +++DV G+ R + ++T P L+ DLD LP PAR L + Sbjct 125 GEETFADLANNQVDGSGSLEDVKGIVYRDPETGSIKTNNPRPLIEDLDSLPFPAR-HLVS 183 Query 159 VLADGFAAS----VFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDY 214 + G + S + ++RGC Y C +C + S ++GK +R++S + VVDEI+ LV +Y Sbjct 184 FESYGISKSQSGGMITSRGCVYNCGYCSS---SLIMGK-KFRSRSPENVVDEIEELVYNY 239 Query 215 DVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRA 274 +N ++ DD F+ ++ RAA A+ + R + V+F+ R+D +V+ DL L A Sbjct 240 HLNDIAFMDDTFML----NKNRAASIADEIKERNLDVSFVASSRVD-MVNQDLLFKLKNA 294 Query 275 GLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDE 334 G+ ++ GVE+GS L +K I + A + + + G++V+ I+ +P ++ Sbjct 295 GMNTIYYGVESGSQRILNLMKKGI--NLKQAENAVKNAKNAGLEVLTSYIIGYPGETQND 352 Query 335 LRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYL-TAKW 379 + ET++ + K + S + P+PGTP+Y D + T W Sbjct 353 MNETIKF--SIKLEPDYCQYSILTPFPGTPIYHDLKDKDLIKTENW 396 >gi|197119669|ref|YP_002140096.1| radical SAM protein with cobalamin binding-like domain [Geobacter bemidjiensis Bem] gi|197089029|gb|ACH40300.1| radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin binding-like domain [Geobacter bemidjiensis Bem] Length=487 Score = 141 bits (355), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 117/357 (33%), Positives = 179/357 (51%), Gaps = 31/357 (8%) Query 43 TPRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 +P +VGFS T LA+ ++ VIG + A+ + L + FDY+V G Sbjct 77 SPAVVGFSATTPTIESAAELARAVKRRRGDTVTVIGGSHASALPKETLEEFPSFDYLVRG 136 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELPTVL 160 +GE+ +L L L A D+ G+A RSE G + + LV DLD LP PARD L L Sbjct 137 EGELTLAELCLRLREGGAGQDIRGIAYRSEDGVRVNSSRELVSDLDSLPFPARDLLDYSL 196 Query 161 ADGFAA----------SVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYL 210 G ++ +F++RGCP C+FC A+ A G+ S R + + DE+D + Sbjct 197 RAGHSSRGFSNALRSGELFTSRGCPVACSFC---AIQATFGR-SVRFRDPLFIADELDRM 252 Query 211 VSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKH 270 V + VN + I DD F + +P +RAA + R GI ++ D R+++V +L + Sbjct 253 VREQKVNHVVIADDTF-TLNP---ERAAVICEILTRSGIR-SWNCDTRVNTVTP-ELLRL 306 Query 271 LHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMF--HP 328 + R G +V GVE+GS L K I T GQ + + ++ GI + G + P Sbjct 307 MRRCGCEKVAFGVESGSPRLLELMGKGI-TVGQ-VENAVRWAREAGIRHVEGNFIIGCDP 364 Query 329 TVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWE 385 + ++L +T RL+R ++ F +S +VPYPGTPL + AG + P WE Sbjct 365 SETREDLEQTRRLIRGLPWS--FVSVSVVVPYPGTPLREKMLAAGLIEPGVP---WE 416 >gi|159149048|dbj|BAF92596.1| methyltransferase [Streptomyces pactum] gi|212379254|gb|ACJ24870.1| putative C-methyltransferase [Streptomyces pactum] Length=575 Score = 138 bits (347), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 101/337 (30%), Positives = 155/337 (46%), Gaps = 11/337 (3%) Query 44 PRLVGFSCIDTFP--EVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 P+ VG S + + + L + R+A V + IG A T N + I + D V G Sbjct 89 PKFVGISIMYDLHIVDAVRLLRCVRKADPSVFVAIGGAFCTYNAKLIAERIPEADCVAFG 148 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLA 161 +GE+ L LA VPG+ E P L DL + PARD L Sbjct 149 EGELTVEGLMECLAAGRDWRSVPGVWFWQEGRVRSSGPPKLPDLHKQAWPARDLLVHHRG 208 Query 162 DGF---AASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNF 218 G AS +++RGC +CTFC + +++R +S VVDEI++L ++ F Sbjct 209 AGIPTPVASTYTSRGCHAKCTFCYVPRAPGVTAGNAWRVRSPVDVVDEIEFLQREFGTRF 268 Query 219 LSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDS-VVDLDLFKHLHRAGLR 277 L DD F A FA +LRR + ++F + R+D+ ++D + + L RAG+ Sbjct 269 LWFNDDNFGGAFQDGYNHAVGFAEEILRRDLKISFHCEFRVDTGLIDREALRTLRRAGMA 328 Query 278 RVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRE 337 +G+ETGS + +RK L + D +Q I++ PG IM P D+L E Sbjct 329 SALLGMETGSPAMAKRFRKGTLV--EYNFDAARMFRQENIELEPGWIMVEPGTTVDDLWE 386 Query 338 TVRLLRATKYTVG---FKFMSRIVPYPGTPLYQAYSD 371 ++ + A V F F+SR + GT +Y +D Sbjct 387 NLKFIVAADIAVSENPFSFISRAIALRGTEMYDKITD 423 >gi|326200980|ref|ZP_08190852.1| cobalamin B12-binding domain protein [Clostridium papyrosolvens DSM 2782] gi|325988548|gb|EGD49372.1| cobalamin B12-binding domain protein [Clostridium papyrosolvens DSM 2782] Length=571 Score = 137 bits (344), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 101/386 (27%), Positives = 178/386 (47%), Gaps = 27/386 (6%) Query 5 AYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCI------DTFPEV 58 AY + I +N + + Q L+ P +VGFS + +T + Sbjct 56 AYLRQNNIPTKIINSNIENKSNRQ------IEDEILADNPVMVGFSILYELHLYNTMEVI 109 Query 59 LWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDA 118 L +R + I IG A+ YE +L D V++G+GE+ L L + Sbjct 110 FNLRKRGYKG----HITIGGPCASFIYEFLLNSTVGIDSVILGEGELPMLTLVNRLKSKQ 165 Query 119 AVDDVPGLARRSEQGQIL-RTPSSLVDLDELPRPARDELPTVLADGFA---ASVFSTRGC 174 + D+ GLA + + ++ DL LP ARD L + G++ AS++S+RGC Sbjct 166 SWKDIDGLAYMHNGEAVYNQKKETISDLSVLPFAARDSLYYLKNQGYSTRTASIYSSRGC 225 Query 175 PYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQ 234 C +C T S+ L + +R +S +++ +E+++LV ++ V +L D FI + Sbjct 226 RGNCIYC-TAPSSSCLELEKWRCRSGESLYEEVEFLVKEFGVEYLYFCDVNFIGYGSKAL 284 Query 235 QRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAY 294 +R F N ++ I +NF +IR+DS + DL L +AGLR + +G+E+GS L + Sbjct 285 ERLEVFCNKIIENNIKINFHAEIRVDS-IKPDLLNLLKKAGLRDLLLGLESGSQRLLNLW 343 Query 295 RKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKY---TVGF 351 RK + A + ++ G + P IM P+ +L +T+ + +K V Sbjct 344 RKGVTVERNLRA--VEMVKSHGFMLEPAMIMVSPSTTKQDLIDTIDFIVESKIYEDNVPM 401 Query 352 KFMSRIVPYPGTPLYQAYSDAGYLTA 377 +++V + G+ + D G L + Sbjct 402 NMFNKMVLFRGSEAERLLRDEGKLDS 427 >gi|148642445|ref|YP_001272958.1| anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase elongator protein [Methanobrevibacter smithii ATCC 35061] gi|148551462|gb|ABQ86590.1| anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase, Elongator protein 3/MiaB/NifB family [Methanobrevibacter smithii ATCC 35061] Length=474 Score = 136 bits (343), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 102/363 (29%), Positives = 171/363 (48%), Gaps = 32/363 (8%) Query 40 LSGTPRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYV 98 L P LV + + T L AQ ++ +V+G T N+ L + D V Sbjct 61 LKRKPDLVALTALTPTIGRALETAQVVKETLPDAIVVMGGYHPTFNFIETLEDENV-DIV 119 Query 99 VVGDGEVAFTKLALALANDAAVDDVPGLARRSEQG-QILRTPSS--LVDLDELPRPARDE 155 + G+GE L AL N +++ DV G+ + +I+ P + + DLDELP PA + Sbjct 120 IRGEGEYIMLNLVQALENQSSLHDVKGIVFEDKNSKEIVVNPEAPLIQDLDELPFPALNL 179 Query 156 LPT-----VLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYL 210 LP + D ++ +TRGCP +C+FC + AM GK R +SV+ +VDEI+YL Sbjct 180 LPMKKYRLLDMDTHMTTMITTRGCPMQCSFCSSAAMH---GK-KIRERSVENIVDEIEYL 235 Query 211 VSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKH 270 ++YD++ ++ DD F K +++ + +L+R I + + R+D+ +D L K Sbjct 236 KTNYDIDTIAFMDDTFTLK----KRKVMAICDEILKRNIEIMWGCTSRVDT-LDEKLLKK 290 Query 271 LHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQ---QLGIDVIPGTIMFH 327 + AG +FIGVE+ +QL + + A NA + +L I I + Sbjct 291 MKEAGCITIFIGVESADQQQLDN-----MCKNTTIAKIENAFKIAHKLKIRTIASVALGM 345 Query 328 PTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAK-WPLGQWEF 386 P + + +TV+ + K + S PYPGT Y+ + + K W ++ Sbjct 346 PGDTKEIMNKTVKFVH--KLKPNYAIYSLATPYPGTRFYKEAFEKNLIKIKDW--SKYTL 401 Query 387 VDP 389 + P Sbjct 402 ITP 404 >gi|253699579|ref|YP_003020768.1| radical SAM protein [Geobacter sp. M21] gi|251774429|gb|ACT17010.1| Radical SAM domain protein [Geobacter sp. M21] Length=488 Score = 136 bits (343), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 114/357 (32%), Positives = 176/357 (50%), Gaps = 31/357 (8%) Query 43 TPRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 +P LVGFS T LA+ ++ VIG + A+ + L + FDY+V G Sbjct 78 SPALVGFSATTPTIESAAGLARAVKRRRGEAVTVIGGSHASALPKETLEEFPSFDYLVRG 137 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELPTVL 160 +GE+ +L+L L + + D+ G+A R +G + P LV DLD LP PARD L Sbjct 138 EGELTLAELSLRLRDGGSDQDIRGIAYRYGEGIRVNPPRELVADLDSLPFPARDLLDYSP 197 Query 161 ADGFAA----------SVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYL 210 G ++ +F++RGCP C+FC A+ A G+ S R + + DE+D + Sbjct 198 RAGHSSRGFSNALRSGELFTSRGCPVACSFC---AIQATFGR-SVRFRDPLFIADELDRM 253 Query 211 VSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKH 270 V + VN + I DD F + +RAA + R GI ++ D R+++V +L + Sbjct 254 VREQKVNHVVIADDTFTL----NPERAASICEILSRSGIR-SWNCDTRVNTVTP-ELLRL 307 Query 271 LHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMF--HP 328 + R G +V GVE+GS L K I T GQ + ++ GI + G + P Sbjct 308 MRRCGCEKVAFGVESGSPRLLELMGKGI-TVGQ-VERAVRWAREAGIRHVEGNFIIGCDP 365 Query 329 TVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWE 385 + ++L +T RL+R ++ F +S +VPYPGTPL + AG + P WE Sbjct 366 SETREDLEQTRRLIRGLPWS--FVSVSVVVPYPGTPLREKMLAAGLIEPGVP---WE 417 >gi|222446056|ref|ZP_03608571.1| hypothetical protein METSMIALI_01705 [Methanobrevibacter smithii DSM 2375] gi|261349405|ref|ZP_05974822.1| magnesium-protoporphyrin IX monomethyl ester cyclase [Methanobrevibacter smithii DSM 2374] gi|222435621|gb|EEE42786.1| hypothetical protein METSMIALI_01705 [Methanobrevibacter smithii DSM 2375] gi|288861768|gb|EFC94066.1| magnesium-protoporphyrin IX monomethyl ester cyclase [Methanobrevibacter smithii DSM 2374] Length=474 Score = 136 bits (342), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 102/363 (29%), Positives = 171/363 (48%), Gaps = 32/363 (8%) Query 40 LSGTPRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYV 98 L P LV + + T L AQ ++ +V+G T N+ L + D V Sbjct 61 LKRKPDLVALTALTPTIGRALETAQVVKETLPDSIVVMGGYHPTFNFIETLEDENV-DIV 119 Query 99 VVGDGEVAFTKLALALANDAAVDDVPGLARRSEQG-QILRTPSS--LVDLDELPRPARDE 155 + G+GE L AL N +++ DV G+ + +I+ P + + DLDELP PA + Sbjct 120 IRGEGEYIMLNLVQALENQSSLHDVKGIVFEDKNSKEIVVNPEAPLIQDLDELPFPALNL 179 Query 156 LPT-----VLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYL 210 LP + D ++ +TRGCP +C+FC + AM GK R +SV+ +VDEI+YL Sbjct 180 LPMKKYRLLDMDTHMTTMITTRGCPMQCSFCSSAAMH---GK-KIRERSVENIVDEIEYL 235 Query 211 VSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKH 270 ++YD++ ++ DD F K +++ + +L+R I + + R+D+ +D L K Sbjct 236 KTNYDIDTIAFMDDTFTLK----KRKVMAICDEILKRNIEIMWGCTSRVDT-LDEKLLKK 290 Query 271 LHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQ---QLGIDVIPGTIMFH 327 + AG +FIGVE+ +QL + + A NA + +L I I + Sbjct 291 MKEAGCITIFIGVESADQQQLDN-----MCKNTTIAKIENAFKIAHKLKIRTIASVALGM 345 Query 328 PTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAK-WPLGQWEF 386 P + + +TV+ + K + S PYPGT Y+ + + K W ++ Sbjct 346 PGDTKEIMNKTVKFVH--KLKPNYAIYSLATPYPGTRFYKEAFEKNLIKIKDW--SKYTL 401 Query 387 VDP 389 + P Sbjct 402 ITP 404 >gi|332159332|ref|YP_004424611.1| methyltransferase [Pyrococcus sp. NA2] gi|331034795|gb|AEC52607.1| methyltransferase [Pyrococcus sp. NA2] Length=465 Score = 132 bits (333), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 94/335 (29%), Positives = 163/335 (49%), Gaps = 21/335 (6%) Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 +A+ A++ + V +V+G T E +++ C D VV G+GE+ F +L AL + + Sbjct 82 VAKIAKRINEDVFVVMGGPHVTFTPELTMKECPCIDAVVRGEGELTFKELVEALEKNRPL 141 Query 121 DDVPGLARRSEQGQILRTPSS--LVDLDELPRPARDELPT--VLADGFA-ASVFSTRGCP 175 + GL+ R E G+I P + ++DE+P P+ D LP DG ++ ++RGCP Sbjct 142 KGILGLSYRKENGKIKNEPPRPLIQNIDEIPMPSYDLLPMDRYKVDGTPFGTIMTSRGCP 201 Query 176 YRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQ 235 + C FC + S GK +R SVD V++E+ L ++Y + DD F +++ Sbjct 202 FNCVFCSS---SLQFGK-RWRGHSVDRVIEELSILRNEYGKKEIEFLDDTFTL----NRK 253 Query 236 RAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYR 295 RA D A + R G+ + + R+++ + + K + G ++ G+E+GS L Sbjct 254 RAIDIAMRIKREGLDITWTASSRVNTFNE-KIAKAMKEGGCHTIYFGIESGSQRILDFIG 312 Query 296 KQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMS 355 K I + + D + ++ G+ + I+ P +E+ T+R A K V F + Sbjct 313 KGITPK--QSIDAVKTAKKAGLRTLGSFIIGFPDETREEVETTIRF--AKKVGVDFAQFT 368 Query 356 RIVPYPGTPLYQ-AYSDAGYLTAKWPLGQWEFVDP 389 PYPGT L+ A LT W ++ +DP Sbjct 369 IATPYPGTRLWAYAVEHNLLLTRNW--RKYTTIDP 401 >gi|325959575|ref|YP_004291041.1| Radical SAM domain-containing protein [Methanobacterium sp. AL-21] gi|325331007|gb|ADZ10069.1| Radical SAM domain protein [Methanobacterium sp. AL-21] Length=472 Score = 132 bits (332), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 93/355 (27%), Positives = 167/355 (48%), Gaps = 28/355 (7%) Query 43 TPRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 +P ++ + + T + L A+ ++ IV+G + NY+ IL+ +D D V +G Sbjct 64 SPDIIALTALTPTIAKALETAEYSKSVCKDSLIVMGGYHPSFNYKEILK-YDFVDVVTIG 122 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELPT-- 158 +GE L +L D + V G+A ++ P L+ DLD LP PAR LP Sbjct 123 EGEETLLDLTRSLEYDLPLTSVNGIAF----DDVVTPPRQLIMDLDSLPLPARHLLPMDS 178 Query 159 ---VLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYD 215 + D +++ ++RGCP +C+FC + A+ R +SVD ++DE++YLV++ Sbjct 179 YKLLNMDTKMSTMITSRGCPMQCSFCSSAALHG----SKLRMRSVDKILDEMEYLVNEMG 234 Query 216 VNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAG 275 + ++ DD F S++R + + R I V + R+DS ++ +L + + +AG Sbjct 235 IETIAFMDDTFTI----SKKRVIELCEGIEERNIDVMWGCTSRVDS-LNKELLRKMKKAG 289 Query 276 LRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDEL 335 VF+GVE+ + L KQ T + D +Q I I ++ P + + Sbjct 290 CITVFMGVESADQQMLDTVNKQ--TTIERIKDAFEVSRQEKIRTIASVVLGMPGDTHESI 347 Query 336 RETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAK-WPLGQWEFVDP 389 + T+ ++ + + S PYPGT YQ + + K W ++ + P Sbjct 348 KNTINFVK--ELNPSYAIFSLATPYPGTRFYQQTLEKDLIKVKDW--SKYTLISP 398 >gi|333987982|ref|YP_004520589.1| Radical SAM domain-containing protein [Methanobacterium sp. SWAN-1] gi|333826126|gb|AEG18788.1| Radical SAM domain protein [Methanobacterium sp. SWAN-1] Length=482 Score = 131 bits (329), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 99/357 (28%), Positives = 175/357 (50%), Gaps = 38/357 (10%) Query 43 TPRLVGFSC-IDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 P++VG + + L + ++ +IG T L++++ D VV+G Sbjct 64 NPQVVGLTASTSNIKKALKYTETVKKVLPDSLTMIGGPHTTFRPTETLKENESVDVVVIG 123 Query 102 DGEVAFTKLALALAND----AAVDDVPGLARRSEQGQI-------LRTPSSLV-DLDELP 149 +GE T + LA +D + DV G+A R + + L P L+ DLD LP Sbjct 124 EGEE--TVVDLADKHDRFGMEKLFDVKGIAYRDTENRNNGENRIRLTEPRPLIQDLDSLP 181 Query 150 RPARDELPTVLADGFAAS------VFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAV 203 PAR +P D + S + ++RGC Y C +C + S ++GK +R++S + V Sbjct 182 FPARHLVP---FDAYGVSKDQEGDMITSRGCVYNCGYCSS---SLIMGK-KFRSRSPENV 234 Query 204 VDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVV 263 VDE++ LVS Y +N ++ DD F+ +++RA A+ + RG+ V+++ R+D +V Sbjct 235 VDEVEELVSKYKINNIAFLDDTFMM----NKRRAGAIADEIKSRGLDVSYVASSRVD-MV 289 Query 264 DLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGT 323 + DL +L +G+ ++ GVE+GS L +K I + A D + A + G+ V+ Sbjct 290 NKDLLTNLKSSGMSTLYYGVESGSQRVLDLMKKGITLK--QAEDAVKAAKSAGLKVLTSF 347 Query 324 IMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYL-TAKW 379 I+ P +E+ +T+ + K + S + P+PGT +Y + + T W Sbjct 348 ILGFPGETAEEIDQTINF--SMKLDADYSQYSILTPFPGTAIYHQLKEKDLIDTENW 402 >gi|94969363|ref|YP_591411.1| radical SAM family Fe-S protein [Candidatus Koribacter versatilis Ellin345] gi|94551413|gb|ABF41337.1| Fe-S protein, radical SAM family [Candidatus Koribacter versatilis Ellin345] Length=553 Score = 130 bits (328), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 101/364 (28%), Positives = 166/364 (46%), Gaps = 9/364 (2%) Query 38 AALSGTPRLVGFSCIDTF--PEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCF 95 +A P +VGFS I F + L Q R A IG +L++E LR Sbjct 67 SARQSKPMIVGFSLIFQFYIRKFDALMQALRAAGVDCHFTIGGHFPSLSHEETLRMLPEL 126 Query 96 DYVVVGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARD 154 D VV +GE+ +LA + D+ G+A R G + SLV DLD LP P R+ Sbjct 127 DSVVRFEGEMTLLELADVIGTGRDWHDLQGIAYRGTTGVVTNPMRSLVDDLDSLPYPERN 186 Query 155 ELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDY 214 P A + ++RGC C+FC R + V++E+ + + Sbjct 187 FEPEKALGRKALPLLASRGCARTCSFCSIQTFYRTAPGKIVRTRKPAKVIEEMQAMHEER 246 Query 215 DVNFLSITDDLFISKHPGSQQRAADFANAVLRRGIS--VNFMVDIRLDSVVDLDLFKHLH 272 ++ DD F P ++ A DF + + R G++ V + ++ R D+ V+ ++F + Sbjct 247 GISIFLFQDDDFPLFGPVWRRWAYDFVDCMHRSGLAQRVIWKINCRADA-VEPEIFTAMR 305 Query 273 RAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQP 332 AGL V++G+E+G+ E L+ KQ+ A + L+Q+G+ G +MF P Sbjct 306 DAGLYLVYMGLESGNEEGLKTLHKQVSVEQNIRA--VEMLKQVGLLFEFGFMMFDPGSTL 363 Query 333 DELRETVRLLRAT-KYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEA 391 + +++ +R LR R++PY GTP+ AG L ++F+DP Sbjct 364 ESIKQNLRFLRTILNDGCAAAVFCRMLPYDGTPIKDELERAGRLLGDVCAPSYDFLDPRV 423 Query 392 SRVY 395 S++Y Sbjct 424 SKMY 427 >gi|78222914|ref|YP_384661.1| cobalamin B12-binding/radical SAM family protein [Geobacter metallireducens GS-15] gi|78194169|gb|ABB31936.1| Cobalamin B12-binding/Radical SAM [Geobacter metallireducens GS-15] Length=472 Score = 130 bits (327), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 108/402 (27%), Positives = 177/402 (45%), Gaps = 52/402 (12%) Query 1 MSIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCI-DTFPEVL 59 +SI A+ + +GI ++ + ET +A + P +VGFSC +F E Sbjct 33 LSIAAFLEARGIGTEVIDCYATPMPA--ETLVA----EVIRRRPDVVGFSCTTSSFLEGY 86 Query 60 WLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAA 119 +A+R ++ G+ V G A A +L DY+V+G+GE F +L L D Sbjct 87 SIAERIKEKAPGITTVFGGAHACSVGVGLLDTFPAIDYLVIGEGEQTFFELVTNL--DHG 144 Query 120 VDDVPGLA-RRSEQGQILRTPSSLVDLDELPRPARDELPTV----------LADGFAASV 168 +PG+ R + +G I + +LD+LP PA LP S+ Sbjct 145 GSGIPGVGYRENGKGVISALREHIANLDDLPFPAYHRLPQFPKRYILPLFSYPKAPNTSI 204 Query 169 FSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFIS 228 S+RGCPY+C++C S +R S + +V+ + L DY + + DDLF + Sbjct 205 ISSRGCPYQCSYCDRSVFSR-----GFRFNSPEYIVEHLKMLNRDYGIRHVFFYDDLFTT 259 Query 229 KHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSY 288 + R A F R + V + RL+ VD +L + L R+G +V G+E+G Sbjct 260 ----DRARVARFCELKERERLPVTYNCIARLEH-VDAELLRLLKRSGCWQVNFGIESGDP 314 Query 289 EQLRAYRK-----QILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLR 343 E ++ +RK ++ + Q DT ++ L + +PG E E++R R Sbjct 315 EVIKKHRKFYGLDEVQRKLQLVRDTGMRVKGLFMVGLPG-----------ETEESIR--R 361 Query 344 ATKYTVGFKF----MSRIVPYPGTPLYQAYSDAGYLTAKWPL 381 Y + +++ P+PG PLY + G WPL Sbjct 362 TIDYALALPLDEINVTKFTPFPGAPLYATIREQGEFDENWPL 403 >gi|222100094|ref|YP_002534662.1| Mg-protoporphyrin IX monomethyl ester oxidative cyclase-related protein [Thermotoga neapolitana DSM 4359] gi|221572484|gb|ACM23296.1| Mg-protoporphyrin IX monomethyl ester oxidative cyclase-related protein [Thermotoga neapolitana DSM 4359] Length=441 Score = 130 bits (326), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 105/333 (32%), Positives = 170/333 (52%), Gaps = 25/333 (7%) Query 42 GTPRLVGFSCIDT--FPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVV 99 G +VG S +DT FP +A+RA+ G +V+G AT YE ILRQ C DYVV Sbjct 58 GEYDVVGIS-VDTVRFPVAEKIAERAKAC--GTTVVMGGPHATAFYETILRQGLC-DYVV 113 Query 100 VGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDEL-- 156 +G+GE AF+ L ++AN +PG+A G I PS + +LD+LP P R+++ Sbjct 114 LGEGERAFSDLVESIANKEKHPHIPGIA-YVRDGDIFVLPSRFIENLDDLPFPDREKVYL 172 Query 157 -PTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYD 215 T A A S+ ++RGCP+ C FC + S +G+ R +SV+ VVDE+ L Sbjct 173 YRTKFAGERATSLITSRGCPFNCEFC---SASQFMGR-RIRWRSVENVVDELKILKKMGY 228 Query 216 VNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVV-DLDLFKHLHRA 274 + + D+ I + +R + +LR+ + + R D ++ D+ + + +A Sbjct 229 GSVIFFDDNFTI-----NPKRVVNLCEEMLRKDLRFKWWAFSRADELLGHEDMVEAMSKA 283 Query 275 GLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDE 334 G + +FIG E+ E L Y K + + A D + L++ IDV ++ Sbjct 284 GCKMLFIGFESADDEVLEEYGKNL--KSGIAFDVVKFLKKYRIDVFASFVIGALKDTKKT 341 Query 335 LRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQ 367 + +TV+ R K ++ +F S + PYPGT L++ Sbjct 342 IEKTVKFARKLKASI-VQF-SILTPYPGTALFE 372 >gi|159149049|dbj|BAF92597.1| methyltransferase [Streptomyces pactum] gi|212379255|gb|ACJ24871.1| putative C-methyltransferase [Streptomyces pactum] Length=578 Score = 129 bits (325), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 100/335 (30%), Positives = 152/335 (46%), Gaps = 18/335 (5%) Query 44 PRLVGFSCIDTFP--EVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 P+ VG S + + + L + R A V + IG A T N + I + D V G Sbjct 89 PKFVGISIMYDLHIVDAVRLLRCVRAADPSVFVAIGGAFCTYNGKLIAERIPEADCVAFG 148 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLA 161 +GE+ L LA VPGL + P L DL + PARD L Sbjct 149 EGELTVEGLMECLAAGRDWRSVPGLWFWQDGRVRSSGPPKLPDLSKQAWPARDVLIHHRE 208 Query 162 DGFA---ASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNF 218 G AS +++RGC +CTFC + +R + + VDEI+YL ++ F Sbjct 209 AGIPTPRASTYTSRGCHAKCTFC-YAPRQPGVENGPWRVRPIGDAVDEIEYLQREFGTRF 267 Query 219 LSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDS-VVDLDLFKHLHRAGLR 277 L DD F A FA +LRRG+ +NF + R+D+ ++D + + L RAG+ Sbjct 268 LWFNDDNFGGAFQDGYHHAVGFAEEILRRGLKINFHCEFRVDTGLIDREALRTLRRAGMD 327 Query 278 RVFIGVETGSYEQLRAYRKQILTRGQDAADTINA---LQQLGIDVIPGTIMFHPTVQPDE 334 +G+ETGS ++ +RK G A +A ++ GI++ PG IM P DE Sbjct 328 LALLGMETGSPGMMKRFRK-----GTTVAYNFDAARLFKEEGIELEPGWIMIEPGTTLDE 382 Query 335 LRETVRLL---RATKYTVGFKFMSRIVPYPGTPLY 366 L E ++ + R + F ++R + GT +Y Sbjct 383 LWENLKFIVTARVHESENPFFLINRAIALRGTEIY 417 >gi|242399824|ref|YP_002995249.1| Fe-S oxidoreductase [Thermococcus sibiricus MM 739] gi|242266218|gb|ACS90900.1| Fe-S oxidoreductase [Thermococcus sibiricus MM 739] Length=527 Score = 129 bits (325), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 115/407 (29%), Positives = 195/407 (48%), Gaps = 44/407 (10%) Query 43 TPRLVGFSCI-DTF--PEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVV 99 P +VGF+ I T+ P ++ + + + + + IV G AT Y ILR+ D+VV Sbjct 64 NPDVVGFTTIASTYVNPSIMIVRKMKERGINPI-IVFGGHHATFTYPLILRE--GIDFVV 120 Query 100 VGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDEL-PT 158 +G+GE F ++ L + V G+A R Q + +V+LD LP PA D L P Sbjct 121 IGEGEQTFREIIERLKEGKDIRSVRGIAYRDGQKVNVSYREPIVNLDNLPIPAYDLLDPD 180 Query 159 VLADGFA------ASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVS 212 V AS+ ++RGCPY C FC + SAM G ++R KS + VVDE+ + V Sbjct 181 VYKASIVGKNVRIASIETSRGCPYNCEFC---SASAMWG-HAWRFKSNERVVDELKF-VK 235 Query 213 DYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGIS-VNFMVDIRLDSVVDL-DLFKH 270 + N++ DD F+ P + + N+++ G++ +N+M+ IR D + +L + Sbjct 236 NLGYNWVFFVDDNFVV--PYKYEERIELLNSIIEEGLNEMNYMIQIRADIIAKHPELAEK 293 Query 271 LHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLG---IDVIPGTIMFH 327 L AG++ F+G+E+GS L+A RK G DT+ A+Q L I G I+ Sbjct 294 LAEAGVKIAFMGIESGSEGVLKAMRK-----GLKKNDTLKAIQLLSEQEIITYGGVIIGA 348 Query 328 PTVQPDELRETVRLLRAT-KYTVGFKFMSRIVPYPGT-PLYQAYSDAGYLTAKWPLGQWE 385 P + + T + ++ + + +S P PG+ Y+A + LT W L ++ Sbjct 349 PYESRKDRKATYKFVQMLGDHGLDVVQISIYTPLPGSDSFYRALKNRALLTIDWDL--YD 406 Query 386 FVDPEASRVYADVVAKVAPDV-GISFDEAEAYFLSRLDEWENVIAGR 431 + P + +V + + F+ E ++ +W + I G+ Sbjct 407 VLHP---------IMRVKEKLWRLYFESREKTYMFYFKKWLHNIEGK 444 >gi|239907228|ref|YP_002953969.1| hypothetical protein DMR_25920 [Desulfovibrio magneticus RS-1] gi|239797094|dbj|BAH76083.1| hypothetical protein [Desulfovibrio magneticus RS-1] Length=667 Score = 129 bits (324), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 102/310 (33%), Positives = 148/310 (48%), Gaps = 25/310 (8%) Query 61 LAQRARQAWDGVRIVIGNAMAT-LNYERILRQHDCF--DYVVVGDGEVAFTKLALALAND 117 LA + R+ +I+IG +A+ L E + C+ D ++ G+GE A ALAL +D Sbjct 88 LAAQVRKRHPRAKILIGGILASSLPTEELA----CYSPDAILRGEGE-ALVPQALALLDD 142 Query 118 AAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELPTVLADGFAASVFSTRGCPYR 177 A DV L + EQ +D+D L PARD LP L ASV ++RGCPYR Sbjct 143 TASGDVLELVQ--EQA---------LDVDALAWPARDMLPWQLKMHAQASVAASRGCPYR 191 Query 178 CTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRA 237 C+FC + +R + +D VVDE+ +L Y++ DD FI S RA Sbjct 192 CSFCSIPKAGPI---RKWRPRDIDDVVDEMRFLYKTYNIAHFYFVDDNFILNSKPSFLRA 248 Query 238 ADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQ 297 FA V + + F R S +D L K L AGL VF+G+E+ S L Y K+ Sbjct 249 ERFAKLVRDKLPCIRFGFMCR-SSAIDKRLLKVLKSAGLAGVFLGIESFSQAVLDRYNKK 307 Query 298 ILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRI 357 ++ I L LGI + PG I F P E+R+T+ +++ + S++ Sbjct 308 ETV--EEHIRAIAILNDLGITINPGFIFFDPWTSASEMRQTISVMKEIDFPSLQSINSKL 365 Query 358 VPYPGTPLYQ 367 Y GT + Q Sbjct 366 TCYRGTAIEQ 375 >gi|220929791|ref|YP_002506700.1| cobalamin B12-binding domain-containing protein [Clostridium cellulolyticum H10] gi|220000119|gb|ACL76720.1| cobalamin B12-binding domain protein [Clostridium cellulolyticum H10] Length=545 Score = 128 bits (321), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 90/327 (28%), Positives = 164/327 (51%), Gaps = 18/327 (5%) Query 76 IGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAVDDVPGLARRSEQGQI 135 IG + T N+ I+ Q D+V+ G+GE+ + +L L +++++ GL RS +G I Sbjct 95 IGGTLPTYNFREIMEQIPLIDFVIRGEGELTWLELVEHLNKGKSLENIEGLIYRSTEGII 154 Query 136 LRTPSSLV-DLDELPRPARDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDS 194 + P +L+ ++ +LP PARD L A + S+RGC +C+FC ++ L Sbjct 155 VNPPRNLIENIGDLPWPARDILKENKLK--TAVISSSRGCTGKCSFC-----ASQLFWKK 207 Query 195 YRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPG-SQQRAADFANAVLRRGISVNF 253 +R + VVDE++Y+V +Y V + D F + PG + +R A ++RR +++++ Sbjct 208 WRGREPIDVVDEMEYIVKEYGVRTFNFIDGSF--EDPGINLKRVRGIAEEIIRRRLNISY 265 Query 254 MVDIRLDSVVDLD--LFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINA 311 VD+R + D L L ++GL IG E+ + L+ Y+K D A Sbjct 266 FVDLRAEFFRKADEALIDLLKKSGLCGACIGYESANEYDLKFYQK--YASVSDNVRAAEA 323 Query 312 LQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKY-TVGFKFMSRIVPYPGTPLYQAYS 370 ++ I+V+PG I F+P + LR + + ++ + +SR+ + GT LY+ Sbjct 324 CRKYEINVVPGFINFNPYSTFEGLRSNIEFMEEYQFANIIHLVISRVKIFTGTVLYEKIK 383 Query 371 DAG--YLTAKWPLGQWEFVDPEASRVY 395 + L+ ++ ++FVD + Y Sbjct 384 EDNLLLLSPEYNEYGYKFVDERITPFY 410 >gi|298529538|ref|ZP_07016941.1| Radical SAM domain protein [Desulfonatronospira thiodismutans ASO3-1] gi|298510974|gb|EFI34877.1| Radical SAM domain protein [Desulfonatronospira thiodismutans ASO3-1] Length=447 Score = 127 bits (320), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 101/362 (28%), Positives = 175/362 (49%), Gaps = 25/362 (6%) Query 57 EVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALAN 116 + L LA +AR+ V + +G + E L+ DYVV G+GE LA LA Sbjct 73 KALALAAQARE--HQVPVALGGPHVSFLPEESLKS-GYVDYVVRGEGEYPMLYLAEFLAG 129 Query 117 DAAVDDVPGLARRSEQGQILRTPSSLV--DLDELPRPARDELP-----TVLADGFAASVF 169 + +++DVP ++ E G+ + P + D+D LP PARD LP T L A S+ Sbjct 130 ERSLEDVPAVSYLLE-GEAVHNPDQCIAKDIDSLPFPARDLLPMDKYRTHLNKKRATSMI 188 Query 170 STRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISK 229 S+RGCP+ C+FC S+ L +RA+ +A+ DEI+++ Y V+ + DD F Sbjct 189 SSRGCPFNCSFCA----SSQLFGARWRAREPEAIFDEIEHVQQRYQVSNILFVDDNFTL- 243 Query 230 HPGSQQRAADFANAVLRRGISVNFMVDIRLDSVV-DLDLFKHLHRAGLRRVFIGVETGSY 288 QR + + ++ +++ ++ R++++V + D+ + + +G+R +F+GVE+ Sbjct 244 ---DPQRTVRISELICKKDLNIQWLCFSRVNTIVENEDMVQGMAESGVRMMFLGVESPDP 300 Query 289 EQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYT 348 L +Y K+I + + + L++ ID + I+ + ++ T+R A K Sbjct 301 RVLESYNKKIT--AETSFRALEILKKYSIDALASFIIGNLNEDSRMIKNTIRF--ANKLN 356 Query 349 VGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWEFVDPEASRVYADVVAKVAPDVGI 408 S + PYPGT LY D LT W + RV A+ + ++ + Sbjct 357 PKTAQFSILTPYPGTRLYNEVKDR-ILTFDWSRYDGMHATIKPDRVRAEELERLIKKAYV 415 Query 409 SF 410 SF Sbjct 416 SF 417 >gi|157364573|ref|YP_001471340.1| radical SAM domain-containing protein [Thermotoga lettingae TMO] gi|157315177|gb|ABV34276.1| Radical SAM domain protein [Thermotoga lettingae TMO] Length=443 Score = 127 bits (318), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 94/317 (30%), Positives = 146/317 (47%), Gaps = 20/317 (6%) Query 55 FPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALAL 114 FP + Q + GV V+G AT YE+IL C DYVV+G+GEV KL AL Sbjct 72 FPLAKQICQVVKS--QGVITVMGGPHATAEYEKILTDGIC-DYVVLGEGEVVLPKLLEAL 128 Query 115 ANDAAVDDVPGLARRSEQGQILRTPSSLVDLDELPRPARDELP---TVLADGFAASVFST 171 N+ D+ GL + + P + DLD LP P R+ T+ A SV ++ Sbjct 129 KNNERKPDLSGLCYIENGTIVSKKPEFVEDLDLLPFPDRENFTAYRTMFDKKMATSVITS 188 Query 172 RGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHP 231 RGCP+ C FC M R +SV+ VV+E+ L +N+ S+ F Sbjct 189 RGCPFNCEFCSASQFMGM----RIRKRSVENVVEELKILKK---MNYGSVI--FFDDNFT 239 Query 232 GSQQRAADFANAVLRRGISVNFMVDIRLDSVV-DLDLFKHLHRAGLRRVFIGVETGSYEQ 290 + R +L+ ++ ++ R D ++ DL + + +AG + +FIG E+ E Sbjct 240 IDKTRTIKLCEQMLKENLNFSWWAFSRADELLGKEDLVEAMSKAGCKMLFIGFESAEDEI 299 Query 291 LRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVG 350 L+ Y K++ A D L++ ID+ IM + +++T++ A K Sbjct 300 LQEYNKKL--SSSIAFDVAKLLKKYKIDLFASFIMGALNDTKESIKKTIKF--AKKLGAE 355 Query 351 FKFMSRIVPYPGTPLYQ 367 S + PYPGT LY+ Sbjct 356 IVQFSIMTPYPGTKLYE 372 >gi|325968646|ref|YP_004244838.1| radical SAM protein [Vulcanisaeta moutnovskia 768-28] gi|323707849|gb|ADY01336.1| Radical SAM domain protein [Vulcanisaeta moutnovskia 768-28] Length=472 Score = 125 bits (315), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 105/357 (30%), Positives = 168/357 (48%), Gaps = 31/357 (8%) Query 41 SGTPRLVGFSCIDTFPEVLWLAQRARQAWDG-VRIVIGNAMATLNYERILRQHDCFDYVV 99 S P +VG + I + A +A + +D + I++G T YE L ++ D VV Sbjct 66 SWQPDIVGLTAITPTVYKAYDAVKAIREYDNDIPIMMGGPHVTFMYEEAL--NNGVDVVV 123 Query 100 VGDGEVAFTKLALALANDA----AVDDVPGLARRSEQGQILRTPS--SLVDLDELPRPAR 153 G+GE +L A+ + + GLA + + Q++RTP + +LDELP PAR Sbjct 124 RGEGEYTTLELVNAIEGHGLDPMHLRAIRGLAFK-DGDQVIRTPDRPPVRNLDELPPPAR 182 Query 154 DELP----TVLADGF-AASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEID 208 LP T+ V ++RGCPY C+FC T S G+ R +S AV DEI+ Sbjct 183 HLLPMDKYTIFGKPIRIVHVMASRGCPYGCSFCST---SYFWGR-MVRYRSAKAVADEIE 238 Query 209 YLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLF 268 ++ Y N + TDD F ++ DF + R + +NF R+D+ +D ++ Sbjct 239 DAMNTYKTNIIVFTDDEFTL----GKRFVYDFLKELRERKLDINFSCGSRVDT-IDKEMM 293 Query 269 KHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHP 328 L G ++ GVE+GS E + K+I + A +++GID + ++ P Sbjct 294 TALKSHGCTALYFGVESGSQETINKIGKRITL--EQAVKVFQWAKEIGIDHVGSFVIGFP 351 Query 329 TVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLY-QAYSDAGYLTAKWPLGQW 384 ++++ T++ A K + + PYPGTPLY QA +D L W W Sbjct 352 WESINDMKNTIKF--AMKLNPTYAQFTVATPYPGTPLYQQALNDN--LIEDWNWEHW 404 >gi|218782942|ref|YP_002434260.1| radical SAM domain-containing protein [Desulfatibacillum alkenivorans AK-01] gi|218764326|gb|ACL06792.1| Radical SAM domain protein [Desulfatibacillum alkenivorans AK-01] Length=484 Score = 125 bits (314), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 91/341 (27%), Positives = 160/341 (47%), Gaps = 27/341 (7%) Query 44 PRLVGFSCIDT-FPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD 102 P LVGFSC+ P V ++ R +IV+GN A++ ++ ++ Q D++V G+ Sbjct 75 PDLVGFSCLTAAMPSVEAMSALIRTDLPKTKIVLGNVHASVFHDYLI-QKGVGDFIVHGE 133 Query 103 GEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELPTVL- 160 GE +L AL + + + GL+ + P+ + DLD+LP PA P L Sbjct 134 GESIIAQLCEALECGESPEKIAGLSMLRNGEAVYTGPAPQIEDLDKLPFPAWHLFPYHLY 193 Query 161 -------ADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSD 213 +G V ++RGCPY C FC + + RA+SV VVDE++YL+ Sbjct 194 ECHPLFGVNGVCLPVIASRGCPYSCFFCAQAS-----AFNGVRARSVQNVVDEMEYLLDR 248 Query 214 YDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFM--VDIRLDSVVDLDLFKHL 271 ++ + D ++ P + + DF ++ R + ++R+D + + +L + Sbjct 249 FNAPMSGLADCMY----PLTHKMGMDFCRQLIDRKLHTKLCWATEMRVD-MAEPELLGIM 303 Query 272 HRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQ 331 A ++ GVE+G+ L+ K+ + +DA I +Q G+ ++ P Sbjct 304 KEANAIQIAYGVESGNEAMLQRLGKKF--KMEDARRAIALTKQAGLSTCGFFVLGFPGET 361 Query 332 PDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDA 372 P R+T+R A + + F + VPYPGTP + ++ D Sbjct 362 PSSCRDTIRF--AKELDLDFAKFNIAVPYPGTPFFDSWWDG 400 >gi|218777948|ref|YP_002429266.1| radical SAM domain-containing protein [Desulfatibacillum alkenivorans AK-01] gi|218759332|gb|ACL01798.1| Radical SAM domain protein [Desulfatibacillum alkenivorans AK-01] Length=494 Score = 125 bits (314), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 114/399 (29%), Positives = 182/399 (46%), Gaps = 43/399 (10%) Query 44 PRLVGFSCIDTFP-EVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD 102 P ++GFS + +V +L ++A +IVIG +A+ + R+L + DYVV G+ Sbjct 68 PEVIGFSSMSIEQDQVDYLLPVFKRALPRAKIVIGGPLASSSGARLLDDANI-DYVVKGE 126 Query 103 GEVAFTKLALAL--ANDAAVDDVPGLARRSEQGQILRTPSSL--VDLDELPRPA------ 152 GE+ FT+L AL D D + GLA R + G+I+ P S DLD LP PA Sbjct 127 GEIPFTQLLEALDGNEDYPFDQIAGLAFRDDSGKIIDNPPSKNRADLDALPYPAYDLINL 186 Query 153 -----RDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEI 207 RD + V A +F++RGCPY C +C + +RA S VVDEI Sbjct 187 QDYVGRDRMTPVRTTQLYAPLFTSRGCPYHCIYCHD------IFSGKFRAMSAMRVVDEI 240 Query 208 DYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVD--IRLDSVVDL 265 +++++ Y V+ + DD+F +QR D + + +RG+ F +R D ++D Sbjct 241 EHMINAYGVHEFEVYDDIFNL----DKQRVKDISAEIKKRGLETYFTFPNGVRGD-ILDR 295 Query 266 DLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIM 325 + + L G + VET S + RK I + + I L I +M Sbjct 296 ETLEALKDMGTVHMAFAVETASPRIQKVLRKNI--NLKKIRENIAIAADLKIFTWGFLMM 353 Query 326 FHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYLTAKWPLGQWE 385 P EL +T+ ++K + F +VP+ GT L Q Y +A + + W+ Sbjct 354 GLPKESRWELWKTIWFATSSKLHGAYFF--PVVPFEGTELAQKYEEA--IESHGEKRLWD 409 Query 386 FVDPEASRVYADVVAKVAPDVGISFDEAEAYFLSRLDEW 424 + PE + + V P +S + AYF+ + W Sbjct 410 YFLPEGA------LGAVGPR-ELSIMHSLAYFIFFFNPW 441 >gi|14590686|ref|NP_142754.1| methyltransferase [Pyrococcus horikoshii OT3] gi|6686119|sp|O58549.1|Y819_PYRHO RecName: Full=Uncharacterized methyltransferase PH0819 gi|3257229|dbj|BAA29912.1| 459aa long hypothetical methyltransferase [Pyrococcus horikoshii OT3] Length=459 Score = 125 bits (313), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 94/358 (27%), Positives = 175/358 (49%), Gaps = 24/358 (6%) Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 +A+ A+ + V +V+G T E +R+ C D VV G+GE+ F +L AL+ + Sbjct 85 VAKIAKNINENVFVVMGGPHVTFTPELTMRECPCIDAVVRGEGELTFKELVDALSKGREL 144 Query 121 DDVPGLARRSEQGQILRTPSS--LVDLDELPRPARDELP--TVLADGFA-ASVFSTRGCP 175 + GL+ + E G++ P + ++DE+P P+ D LP ADG V ++RGCP Sbjct 145 KGILGLSYK-ENGKVRNEPPRPLIQNVDEIPIPSYDLLPMDKYKADGVPFGVVMTSRGCP 203 Query 176 YRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQ 235 + C FC + S GK +R SV+ V++E+ L +Y + + DD F +++ Sbjct 204 FNCVFCSS---SLQFGK-RWRGHSVERVIEELSILHYEYGIKEIEFLDDTFTL----NKK 255 Query 236 RAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYR 295 RA D + + + G+ +++ R+++ + + K + G V+ G+E+ S L Sbjct 256 RAIDISLRIKQEGLDISWTASSRVNTFNE-KVAKAMKEGGCHTVYFGIESASPRILEFIG 314 Query 296 KQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMS 355 K I Q + D + ++ G+ + I+ P +E+ T++ A K + + + Sbjct 315 KGITP--QQSIDAVKTAKKFGLHALGSFIIGFPDETREEVEATIKF--AKKLDIDYAQFT 370 Query 356 RIVPYPGTPLYQ-AYSDAGYLTAKWPLGQWEFVDP--EASRVYADVVAKVAPDVGISF 410 PYPGT L++ A ++ LT W ++ +DP + ++ ++K+ ISF Sbjct 371 IATPYPGTRLWEYAIANNLLLTMNW--RKYTTIDPVMKLKHFTSEQISKLLRKAYISF 426 >gi|170288989|ref|YP_001739227.1| cobalamin B12-binding domain-containing protein [Thermotoga sp. RQ2] gi|170176492|gb|ACB09544.1| cobalamin B12-binding domain protein [Thermotoga sp. RQ2] Length=441 Score = 124 bits (312), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 93/318 (30%), Positives = 168/318 (53%), Gaps = 22/318 (6%) Query 55 FPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALAL 114 FP V +A++A+ V +V+G AT Y IL++ C DYVV+G+GE AF+ L ++ Sbjct 72 FPVVERIAKKAKA--QNVTVVMGGPHATAYYHEILQKGLC-DYVVLGEGERAFSDLVESI 128 Query 115 ANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELP---TVLADGFAASVFS 170 A++ +PG+A + G+++ PS + +LD+LP P R+++ T A A S+ + Sbjct 129 ASNEKYPLIPGVAYMKD-GEVIALPSRFLENLDDLPFPDREKVHLYRTKFAGERATSLIT 187 Query 171 TRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKH 230 +RGCP+ C FC S +G+ R +S++ V+DE+ L + + D+ I Sbjct 188 SRGCPFNCEFCSA---SQFMGR-RIRWRSIENVIDELKILKKLGYGSVIFFDDNFTI--- 240 Query 231 PGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDL-DLFKHLHRAGLRRVFIGVETGSYE 289 + +R + ++R+ + + R D ++ D+ + + +AG R +FIG E+ + E Sbjct 241 --NPKRVVNLCEEMMRKDLRFKWWAFSRADELLGREDMVEAMSKAGCRMLFIGFESANDE 298 Query 290 QLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTV 349 L Y K + + A D +N L++ IDV ++ + +TV+L + K ++ Sbjct 299 VLEEYGKNL--KSDIAFDVMNLLKKYKIDVFASFVIGALKDTRKTIEKTVKLAKKLKASI 356 Query 350 GFKFMSRIVPYPGTPLYQ 367 +F S + PYPGT L++ Sbjct 357 -VQF-SILTPYPGTVLFE 372 >gi|325958322|ref|YP_004289788.1| Radical SAM domain-containing protein [Methanobacterium sp. AL-21] gi|325329754|gb|ADZ08816.1| Radical SAM domain protein [Methanobacterium sp. AL-21] Length=450 Score = 124 bits (310), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 88/331 (27%), Positives = 156/331 (48%), Gaps = 25/331 (7%) Query 43 TPRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVG 101 +P ++ + + T L A+ +++ V+G T + +L+ +D D VV G Sbjct 64 SPDIIAITSVTPTIGSALETAKLSKEVCPNAVTVLGGYHPTFTFPEMLK-NDFVDIVVKG 122 Query 102 DGEVAFTKLALALANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELP--- 157 +GE+ L AL + +V G+A R + P ++ DLD LP PAR LP Sbjct 123 EGELTMVDLVDALEKGRDLQEVEGIATR----DFVTEPRKIIEDLDSLPFPARHLLPMDE 178 Query 158 -TVLADGFAA-SVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYD 215 +L ++ S RGCPY+C+FC + AM R +S +VVDE+++LV+++D Sbjct 179 YKILNMKLTTGTIISGRGCPYQCSFCASSAMHG----HKLRLRSAKSVVDEMEHLVNEHD 234 Query 216 VNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHLHRAG 275 + ++ DD F S++R + A+ RG+ + R+D++ + DL K + AG Sbjct 235 IEMVAFMDDTFTI----SKKRVYEICEAIKERGLKNYWGCTARVDTISE-DLLKTMKDAG 289 Query 276 LRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDEL 335 +F+GVE+ + L K+ T +T ++ + I ++ P + Sbjct 290 CITMFLGVESADQQVLNEVNKK--TNIAKIKETFELTRKYDMRTIASVVLGMPGDTKSSI 347 Query 336 RETVRLLRATKYTVGFKFMSRIVPYPGTPLY 366 R T+ ++ + + + S PYPGT Y Sbjct 348 RNTINFVKQLEPS--YAVFSLATPYPGTDFY 376 >gi|326391529|ref|ZP_08213061.1| Radical SAM domain protein [Thermoanaerobacter ethanolicus JW 200] gi|325992410|gb|EGD50870.1| Radical SAM domain protein [Thermoanaerobacter ethanolicus JW 200] Length=444 Score = 124 bits (310), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 97/346 (29%), Positives = 176/346 (51%), Gaps = 32/346 (9%) Query 43 TPRLVGFSCIDTFPEV---LWLAQRAR-QAWDGVRIVIGNAMATLNYERILRQHDCFDYV 98 +P +VG S I+ P + L +A R R + +DG+ IV G +T Y++IL + D V Sbjct 61 SPDIVGIS-INFAPALNSGLRIADRLRKENFDGI-IVFGGNTSTFLYKKILTE-SYGDIV 117 Query 99 VVGDGEVAFTKLALALANDAAVDD-------VPGLARRSEQGQILRTPSS--LVDLDELP 149 V+ +GE F +L L + ++ + G+A ++ +G+++ T + LDEL Sbjct 118 VMYEGEHTFKELITILQKCSNQENFIEKLSGIRGIAFKTGKGEVITTQKREFVTQLDELK 177 Query 150 RPARDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDY 209 P R A++ S+RGCPY C +C T +AM G++ +R +S +V EI+Y Sbjct 178 IPNRTYHDNFYKLSKMATILSSRGCPYSCFYCST---TAMWGRN-WRGRSAHNIVAEIEY 233 Query 210 LVSDY-DVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLF 268 + S Y ++ DD F+ ++RA +FA ++ + + + F R++ ++ DL Sbjct 234 IRSLYPNICTFGFVDDNFLV----DKKRAREFAELLISKNLDITFGFSARVEH-LEYDLL 288 Query 269 KHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHP 328 K L +AGL ++F+G+E+GS LR + + + + ++ LGI V ++ P Sbjct 289 KTLKKAGLSKIFLGIESGSPRILRLLHRNYTP--YEVIEKVGYIENLGIKVTASFMVGIP 346 Query 329 TVQPDELRETVRLLRATKYTVGFKFMSRI-VPYPGTPLYQAYSDAG 373 D++ ET +L++ + + I P+PGTP ++ + G Sbjct 347 FETKDDVDETFKLIKNIPAS---EIQCHIFTPFPGTPCFEKPDNFG 389 >gi|326201007|ref|ZP_08190879.1| cobalamin B12-binding domain protein [Clostridium papyrosolvens DSM 2782] gi|325988575|gb|EGD49399.1| cobalamin B12-binding domain protein [Clostridium papyrosolvens DSM 2782] Length=543 Score = 123 bits (309), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 88/348 (26%), Positives = 152/348 (44%), Gaps = 18/348 (5%) Query 2 SIKAYAKTQGIAVTSVNGLVAGHGSVQETWLAMQSAAALSGTPRLVGFSCIDTFPEVLW- 60 SI AY + + V +N +L ++ + P L+G T +V++ Sbjct 28 SIAAYLRKENFDVELINS--------SRKYLDLERIYEMK--PDLIGLPVYSTTEKVVYE 77 Query 61 LAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAV 120 + ++ ++ +I G TL + ++ ++ D+++ G+GE+ F L A+ ND+ Sbjct 78 VCKKIKEKVPNAKICFGAYWPTLCGDILMEKYPMVDFIIKGEGEIVFKNLVTAMENDSGY 137 Query 121 DDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELPTVLADGFAASVFSTRGCPYRCT 179 +V GL R I +L+ DLD LP P RD L + A + ++RGC C+ Sbjct 138 SNVKGLLYRDGDKIIENEREALIEDLDSLPFPERDLLRNNMLK--YAYISTSRGCKANCS 195 Query 180 FCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAAD 239 FC GK+ +R +S + VV E+ +V +Y+VN DD F + R + Sbjct 196 FCWHNDFWGTNGKNQWRGRSPENVVREVKQIVDEYNVNRFWFIDDSFEDCNKSCPNRMWE 255 Query 240 FANAVLRRGISVNFMVDIRLDSVVDLD--LFKHLHRAGLRRVFIGVETGSYEQLRAYRKQ 297 A ++ + +++ R + D K L +G G+E+G+ E L+ Y K Sbjct 256 IAEKIIENNLHISYETYFRAEVYKQFDEKKIKLLKDSGFVGTIFGIESGNAEDLKLYNKP 315 Query 298 ILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRAT 345 +D +TI + I + G I F+P L E V L T Sbjct 316 --ATAEDNYNTIKYFRDNDIAIDIGFINFNPYSTIKRLSENVDYLEKT 361 >gi|333986756|ref|YP_004519363.1| Radical SAM domain-containing protein [Methanobacterium sp. SWAN-1] gi|333824900|gb|AEG17562.1| Radical SAM domain protein [Methanobacterium sp. SWAN-1] Length=451 Score = 123 bits (309), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 101/387 (27%), Positives = 178/387 (46%), Gaps = 30/387 (7%) Query 13 AVTSVNGL---VAGHGSVQETWLAMQSAAALSGTPRLVGFSCID-TFPEVLWLAQRARQA 68 AV NG+ + +++ TW +++ ++ P +V + + T + L A R+ Sbjct 32 AVLEENGINVSIIDASALEMTWEDLEAELKMA-PPDVVAITALTPTISQALKSADITRKT 90 Query 69 WDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAVDDVPGLAR 128 IV+G T NYE +L + D D VV G+GE L L N + +V G+A Sbjct 91 CPDTVIVMGGYHPTFNYEEVL-ESDSVDVVVRGEGEYTMLDLVKTLENGGDLAEVKGIAF 149 Query 129 RSEQGQILRTPSSLVDLDELPRPARDELPTVLADGF-----AASVFSTRGCPYRCTFCGT 183 + + R P + DLD LP PAR LP F +++ +TRGCP +C+FC Sbjct 150 KDTVTPV-RPP--ITDLDNLPFPARHLLPMDHYKLFNMKTNMSTMITTRGCPMQCSFCA- 205 Query 184 GAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANA 243 SA L R +S VVDE+++LV D++V ++ DD F + ++R + Sbjct 206 ---SAALHGPKLRLRSPKNVVDEMEHLVKDHNVGTIAFMDDTFTLR----RKRVLEICEE 258 Query 244 VLRRGISVNFMVDIRLDSVVDLDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQ 303 + +R + V + R+D++ D+ K + AG +F+GVE+ + L K Sbjct 259 IKKRDLDVLWGCTARVDTLSG-DVIKQMREAGCIAMFMGVESADQQVLDEVNKNTSIAKI 317 Query 304 DAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGT 363 +A ++ +++ I ++ P + ++ TV+ ++ + + S PYPGT Sbjct 318 RSAFELSKKEKM--RTIASVVLGMPGDTKESIKRTVKFVK--ELNPSYAVFSLATPYPGT 373 Query 364 PLYQAYSDAGYLTAK-WPLGQWEFVDP 389 YQ + + K W ++ + P Sbjct 374 RFYQQTLEKNLIKVKDW--SKYTLISP 398 >gi|148270385|ref|YP_001244845.1| radical SAM domain-containing protein [Thermotoga petrophila RKU-1] gi|147735929|gb|ABQ47269.1| Radical SAM domain protein [Thermotoga petrophila RKU-1] Length=441 Score = 123 bits (308), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 92/318 (29%), Positives = 166/318 (53%), Gaps = 22/318 (6%) Query 55 FPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALAL 114 FP V +A++A+ V +V+G T Y IL++ C DYVV+G+GE AF+ L ++ Sbjct 72 FPVVERIAEKAKA--QNVTVVMGGPHTTACYHEILQKGLC-DYVVLGEGERAFSDLVESI 128 Query 115 ANDAAVDDVPGLARRSEQGQILRTPSSLV-DLDELPRPARDELP---TVLADGFAASVFS 170 A+ +PG+A + G+++ PS + +LD+LP P R+++ T A A S+ + Sbjct 129 ASSEKYPLIPGVAYMKD-GEVIALPSRFLENLDDLPFPDREKVHLYRTKFAGERATSLIT 187 Query 171 TRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLVSDYDVNFLSITDDLFISKH 230 +RGCP+ C FC S +G+ R +S++ V+DE+ L + + D+ I Sbjct 188 SRGCPFNCEFCSA---SQFMGR-RIRWRSIENVIDELKILKKLGYGSVIFFDDNFMI--- 240 Query 231 PGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDL-DLFKHLHRAGLRRVFIGVETGSYE 289 + +R + ++R+ + + R D ++ D+ + + +AG R +FIG E+ + E Sbjct 241 --NPKRVVNLCEEMMRKDLRFKWWAFSRADELLGREDMVEAMSKAGCRMLFIGFESANDE 298 Query 290 QLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTV 349 L Y K + + A D +N L++ IDV ++ + +TV+L + K ++ Sbjct 299 VLEEYGKNL--KSDIAFDVMNLLKKYKIDVFASFVIGALKDTRKTIEKTVKLAKKLKASI 356 Query 350 GFKFMSRIVPYPGTPLYQ 367 +F S + PYPGT L++ Sbjct 357 -VQF-SILTPYPGTVLFE 372 >gi|219851304|ref|YP_002465736.1| Radical SAM domain protein [Methanosphaerula palustris E1-9c] gi|219545563|gb|ACL16013.1| Radical SAM domain protein [Methanosphaerula palustris E1-9c] Length=489 Score = 123 bits (308), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 100/351 (29%), Positives = 168/351 (48%), Gaps = 29/351 (8%) Query 44 PRLVGFSCID-TFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD 102 P LVG + T + ++ R A I IG T L + + VV+G+ Sbjct 66 PDLVGLTATTATISKAFQYVRKIRDAVPECFIFIGGPHVTFLPSETLAECRELNAVVIGE 125 Query 103 GEVAFTKL--ALALANDAAVDDVPGLARRSEQG---QILRTPSS--LVDLDELPRPARDE 155 GE L + ++ + + V G+A R G +I+ TP+ + +LD LP PAR Sbjct 126 GEETVVDLVTSFSMTDPHWPETVRGIAYRRNDGDRERIVVTPARELIQNLDALPFPARHL 185 Query 156 LP-----TVLADGFAASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYL 210 +P D + ++RGC + +C S+ L +RA+S VVDE++ L Sbjct 186 VPFNEYKLFDKDATIGYMITSRGCTFASNYCS----SSHLMGGMFRARSPKNVVDEVEEL 241 Query 211 VSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKH 270 VS Y V+ + DD F+ ++ RA D A+ + RG+ ++F+ R+++ V+ DL Sbjct 242 VSTYHVDTIEFLDDNFML----NRSRAIDIAHEIRSRGLDISFVASSRVNA-VNRDLLME 296 Query 271 LHRAGLRRVFIGVETGSYEQLRAYRKQI-LTRGQDAADTINALQQLGIDVIPGTIMFHPT 329 L +AGL ++ GVE+GS L+ K+I L+ +DA + + GI V+ I+ +P Sbjct 297 LKKAGLSTIYYGVESGSLRTLKLMNKRITLSMAEDA---VRIAKDCGISVLTSFIIGYPG 353 Query 330 VQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQAYSDAGYL-TAKW 379 +++ T+R A + + + + PYPGTP++Q L T W Sbjct 354 ETYEDMNATIRF--AIRLDPDYAQFTILTPYPGTPIFQELKKNNLLATEDW 402 >gi|144897660|emb|CAM74524.1| Coenzyme B12-binding:Radical SAM [Magnetospirillum gryphiswaldense MSR-1] Length=439 Score = 122 bits (307), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 112/338 (34%), Positives = 149/338 (45%), Gaps = 29/338 (8%) Query 44 PRLVGFS-CIDTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD 102 P LVG S F EV +A+ R A G + +G T E L D V++G+ Sbjct 67 PELVGLSFTTPLFSEVADIARHLRAAGWGGHLTLGGVHVTALPEETLTLLPEADSVILGE 126 Query 103 GEVAFTKLALALANDAAVDDVPGLARRSEQG---QILRTPSSLVDLDELPRPARDELPT- 158 GE + LA ALA +D VPGL R G + P LD LP PA D P Sbjct 127 GERSMVLLAEALATGTGLDQVPGLIYRDGDGGLRAVAAQPWQAPQLDPLPLPALDLYPME 186 Query 159 -VLADGFAAS------VFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVVDEIDYLV 211 +D + +TRGCPY C FC +G S GK R S+D V++E L Sbjct 187 RFTSDFWGGHDRRMGVQITTRGCPYHCEFCASGGES--WGK--LRYHSIDRVIEESWRLK 242 Query 212 SDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVDLDLFKHL 271 + + ++L DD F K R D A + G+ + FMV R+D++ + +L L Sbjct 243 NQFGADYLVFNDDTFTVK----PSRCLDIAQRLRAEGLDLPFMVTARVDAISE-NLLAEL 297 Query 272 HRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAADTINALQQLGIDVIPGTIMF--HPT 329 AG + GVE+GS E LR K T A + Q+ GI V+ G MF +P Sbjct 298 AAAGCFMITYGVESGSNEVLRHIGKNTTT--DLARKAVRDAQKHGIKVV-GNFMFGHYPD 354 Query 330 VQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPLYQ 367 DE L A + S VPYPGT LY+ Sbjct 355 ---DEASCQSTLDLAQELACDVSQFSITVPYPGTQLYR 389 >gi|308275233|emb|CBX31830.1| hypothetical protein N47_N26550 [uncultured Desulfobacterium sp.] Length=475 Score = 122 bits (307), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 100/367 (28%), Positives = 170/367 (47%), Gaps = 61/367 (16%) Query 44 PRLVGFSCI-DTFPEVLWLAQRARQAWDGVRIVIGNAMATLNYERILRQHDCFDYVVVGD 102 P +G SC TF + + +A+ A+ +++V G A + ER+L+ + DY VVG+ Sbjct 68 PAFIGLSCTTSTFLDGVRIAEMAKSILPQIQVVFGGAHVSALKERVLKDYPVIDYTVVGE 127 Query 103 GEVAFTKLALALANDAAVDDVPGLARRSEQGQILRT---PSSLVDLDELPRPARDELPTV 159 GE +L N+ + V GL R + G+I T P+SL +LD LP PA ++L Sbjct 128 GEETLAELLENGRNN--ISSVMGLIYREKTGEICYTGKRPNSL-ELDLLPFPAYEKL--- 181 Query 160 LADGF---------------AASVFSTRGCPYRCTFCGTGAMSAMLGKDSYRAKSVDAVV 204 +GF ++S ++RGCPY C++C ++ G+ S+R S + + Sbjct 182 --EGFPLAYRAPLFNYPKAPSSSCITSRGCPYACSYCD----RSVFGR-SFRFNSAEYMY 234 Query 205 DEIDYLVSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLRRGISVNFMVDIRLDSVVD 264 + + YL + V + DD F K ++R DFA ++ R + V+F +R + + D Sbjct 235 EHVRYLNERFGVRHIIFYDDQFTFK----RERVVDFAKMMINRPLGVSFNCVVRAEHI-D 289 Query 265 LDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDAAD------TINALQQLGID 318 DL L AG + IG+ETG + +L+R + AD I +++ GI Sbjct 290 YDLLLMLKEAGCWMISIGIETGD--------ENLLSRHRQNADLAFLSEKIKLIKKAGIR 341 Query 319 VIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKF----MSRIVPYPGTPLYQAYSDAGY 374 G M P E + ++ +Y +++ P+PG+P+Y+ + G Sbjct 342 T-KGLFMIG---LPGETEAAIN--KSMEYVFSNPIDELNVAKFTPFPGSPIYENIHEMGE 395 Query 375 LTAKWPL 381 W L Sbjct 396 FNEDWEL 402 >gi|344925566|ref|ZP_08779027.1| radical SAM protein [Candidatus Odyssella thessalonicensis L13] Length=532 Score = 122 bits (306), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 91/303 (31%), Positives = 148/303 (49%), Gaps = 11/303 (3%) Query 71 GVRIVIGNAMATLNYERILRQHDCFDYVVVGDGEVAFTKLALALANDAAVDDVPGLAR-R 129 G +IV+G TL E+ D +V+G+GE F +L A N+A +V G+A Sbjct 99 GTKIVLGGYFPTLQPEKSYEIIPQADALVMGEGEEIFYQLIKAFENNAPKQEVQGIAYWD 158 Query 130 SEQGQILRTPSSLVD--LDELPRPARDELPTVLADGFAASVFSTRGCPYRCTFCGTGAMS 187 SE +++TP ++ LD +P P R L ++ + +RGC CTFC + Sbjct 159 SESQTLIKTPRPPLEENLDRIPWPRR-YLAIKMSSEDEVFLEGSRGCYSFCTFCAIRPFA 217 Query 188 AMLGKDSYRAKSVDAVVDEIDYL-VSDYDVNFLSITDDLFISKHPGSQQRAADFANAVLR 246 G ++R +S ++VDEI L + D+ D FI P + +R +FAN + Sbjct 218 GFTG-SAWRPRSARSIVDEIHSLRKQNPDLKTFRFIDSDFIG--PVNHERTIEFANLAKQ 274 Query 247 RGISVNFMVDIRLDSVVD-LDLFKHLHRAGLRRVFIGVETGSYEQLRAYRKQILTRGQDA 305 + F ++ R +V D+ K L AG+ R++IG+E+GS + L K+ T Q+ Sbjct 275 ELSGIRFHLEGRAVAVCKSYDVLKQLKEAGVYRIYIGIESGSQKILDKMNKR--TTVQEN 332 Query 306 ADTINALQQLGIDVIPGTIMFHPTVQPDELRETVRLLRATKYTVGFKFMSRIVPYPGTPL 365 D++ L +LGID G IMF P +++ V L+ KF + ++ P TP Sbjct 333 IDSLRILNELGIDGTYGFIMFTPWTDIEDIDANVAFLKTVGNIQMNKFFTELLLIPNTPA 392 Query 366 YQA 368 Y++ Sbjct 393 YKS 395 Lambda K H 0.322 0.136 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 894358852716 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40