BLASTP 2.2.25+
Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
15,229,318 sequences; 5,219,829,388 total letters
Query= Rv0260c
Length=381
Score E
Sequences producing significant alignments: (Bits) Value
gi|15607401|ref|NP_214774.1| bifunctional uroporphyrinogen-III s... 757 0.0
gi|289748742|ref|ZP_06508120.1| transcriptional regulator [Mycob... 755 0.0
gi|340625297|ref|YP_004743749.1| putative transcriptional regula... 752 0.0
gi|240168480|ref|ZP_04747139.1| bifunctional uroporphyrinogen-II... 622 3e-176
gi|296167538|ref|ZP_06849890.1| bifunctional uroporphyrinogen-II... 612 4e-173
gi|342859267|ref|ZP_08715921.1| bifunctional uroporphyrinogen-II... 597 8e-169
gi|183980548|ref|YP_001848839.1| transcriptional regulatory prot... 587 1e-165
gi|41409804|ref|NP_962640.1| bifunctional uroporphyrinogen-III s... 586 2e-165
gi|254777340|ref|ZP_05218856.1| bifunctional uroporphyrinogen-II... 584 8e-165
gi|118464556|ref|YP_884021.1| bifunctional uroporphyrinogen-III ... 582 3e-164
gi|118616899|ref|YP_905231.1| bifunctional uroporphyrinogen-III ... 582 5e-164
gi|254820412|ref|ZP_05225413.1| bifunctional uroporphyrinogen-II... 580 1e-163
gi|118472313|ref|YP_884845.1| bifunctional uroporphyrinogen-III ... 556 2e-156
gi|108797243|ref|YP_637440.1| bifunctional uroporphyrinogen-III ... 538 8e-151
gi|126432866|ref|YP_001068557.1| bifunctional uroporphyrinogen-I... 537 1e-150
gi|120401327|ref|YP_951156.1| bifunctional uroporphyrinogen-III ... 518 6e-145
gi|145220984|ref|YP_001131662.1| bifunctional uroporphyrinogen-I... 502 5e-140
gi|333988881|ref|YP_004521495.1| bifunctional uroporphyrinogen-I... 459 4e-127
gi|54026532|ref|YP_120774.1| bifunctional uroporphyrinogen-III s... 404 2e-110
gi|333921413|ref|YP_004494994.1| hypothetical protein AS9A_3756 ... 402 7e-110
gi|317507942|ref|ZP_07965637.1| uroporphyrinogen-III synthase He... 401 7e-110
gi|226305696|ref|YP_002765656.1| hypothetical protein RER_22090 ... 386 3e-105
gi|229490999|ref|ZP_04384832.1| uroporphyrinogen-III synthetase ... 386 3e-105
gi|169630601|ref|YP_001704250.1| bifunctional uroporphyrinogen-I... 386 3e-105
gi|296139101|ref|YP_003646344.1| uroporphyrinogen III synthase H... 382 7e-104
gi|296392987|ref|YP_003657871.1| uroporphyrinogen III synthase H... 376 3e-102
gi|226365838|ref|YP_002783621.1| bifunctional uroporphyrinogen-I... 376 3e-102
gi|302551781|ref|ZP_07304123.1| uroporphyrinogen-III synthase [S... 375 5e-102
gi|262203383|ref|YP_003274591.1| uroporphyrinogen III synthase H... 374 1e-101
gi|111023331|ref|YP_706303.1| bifunctional uroporphyrinogen-III ... 373 3e-101
gi|297194081|ref|ZP_06911479.1| uroporphyrinogen-III synthetase ... 372 7e-101
gi|291453788|ref|ZP_06593178.1| conserved hypothetical protein [... 370 2e-100
gi|312140629|ref|YP_004007965.1| transcriptional regulator [Rhod... 368 8e-100
gi|297159962|gb|ADI09674.1| bifunctional uroporphyrinogen-III sy... 367 1e-99
gi|29831663|ref|NP_826297.1| bifunctional uroporphyrinogen-III s... 367 2e-99
gi|297200053|ref|ZP_06917450.1| uroporphyrinogen-III synthase [S... 365 5e-99
gi|329936531|ref|ZP_08286267.1| transcriptional regulator [Strep... 364 1e-98
gi|297561132|ref|YP_003680106.1| uroporphyrinogen III synthase H... 363 3e-98
gi|291439327|ref|ZP_06578717.1| conserved hypothetical protein [... 362 8e-98
gi|320010503|gb|ADW05353.1| Uroporphyrinogen III synthase HEM4 [... 361 1e-97
gi|345015563|ref|YP_004817917.1| Uroporphyrinogen III synthase H... 359 3e-97
gi|290959973|ref|YP_003491155.1| transcriptional regulator [Stre... 357 2e-96
gi|343927594|ref|ZP_08767062.1| hypothetical protein GOALK_097_0... 355 5e-96
gi|345000010|ref|YP_004802864.1| Uroporphyrinogen III synthase H... 355 9e-96
gi|239988104|ref|ZP_04708768.1| bifunctional uroporphyrinogen-II... 354 1e-95
gi|326779020|ref|ZP_08238285.1| Uroporphyrinogen III synthase HE... 353 2e-95
gi|182438369|ref|YP_001826088.1| bifunctional uroporphyrinogen-I... 353 3e-95
gi|289771313|ref|ZP_06530691.1| conserved hypothetical protein [... 353 3e-95
gi|328882767|emb|CCA56006.1| putative transcriptional regulator ... 353 3e-95
gi|21221403|ref|NP_627182.1| bifunctional uroporphyrinogen-III s... 353 4e-95
>gi|15607401|ref|NP_214774.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium tuberculosis H37Rv]
gi|15839642|ref|NP_334679.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium tuberculosis CDC1551]
gi|31791438|ref|NP_853931.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium bovis AF2122/97]
74 more sequence titles
Length=381
Score = 757 bits (1954), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 381/381 (100%), Positives = 381/381 (100%), Gaps = 0/381 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL
Sbjct 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE
Sbjct 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR
Sbjct 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM
Sbjct 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV
Sbjct 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN
Sbjct 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHDDV 381
IVATVVKRGYRLAVDSRHDDV
Sbjct 361 IVATVVKRGYRLAVDSRHDDV 381
>gi|289748742|ref|ZP_06508120.1| transcriptional regulator [Mycobacterium tuberculosis T92]
gi|289689329|gb|EFD56758.1| transcriptional regulator [Mycobacterium tuberculosis T92]
Length=381
Score = 755 bits (1949), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 380/381 (99%), Positives = 380/381 (99%), Gaps = 0/381 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL
Sbjct 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE
Sbjct 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR
Sbjct 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKPAPLGGVFDHLVT IARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM
Sbjct 181 WKPAPLGGVFDHLVTAIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV
Sbjct 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN
Sbjct 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHDDV 381
IVATVVKRGYRLAVDSRHDDV
Sbjct 361 IVATVVKRGYRLAVDSRHDDV 381
>gi|340625297|ref|YP_004743749.1| putative transcriptional regulatory protein [Mycobacterium canettii
CIPT 140010059]
gi|340003487|emb|CCC42607.1| putative transcriptional regulatory protein [Mycobacterium canettii
CIPT 140010059]
Length=381
Score = 752 bits (1942), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 379/381 (99%), Positives = 379/381 (99%), Gaps = 0/381 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL
Sbjct 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE
Sbjct 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESSHEVLEYLLESGVS TRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR
Sbjct 121 WSPDSESSHEVLEYLLESGVSSTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKPAPLGGVFD LVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM
Sbjct 181 WKPAPLGGVFDQLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV
Sbjct 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN
Sbjct 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHDDV 381
IVATVVKRGYRLAVDSRHDDV
Sbjct 361 IVATVVKRGYRLAVDSRHDDV 381
>gi|240168480|ref|ZP_04747139.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium kansasii ATCC 12478]
Length=380
Score = 622 bits (1605), Expect = 3e-176, Method: Compositional matrix adjust.
Identities = 315/377 (84%), Positives = 335/377 (89%), Gaps = 0/377 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MAQ +S PL GYRIAVTSARRA+ELCALLRRQGAEVCSAPAI MIALPDDDEL NT+AL
Sbjct 1 MAQRNSEPLRGYRIAVTSARRADELCALLRRQGAEVCSAPAISMIALPDDDELHRNTQAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IADPPDILVAHTGIG RGW+AAAEGWGLA L+ LS+AR+ISRGPKATG LRAAGLREE
Sbjct 61 IADPPDILVAHTGIGVRGWIAAAEGWGLAGGLIGVLSAARVISRGPKATGELRAAGLREE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESS EVL+YLL SGVS RIAVQLHGAAD WDPFPEF+GGLR AGA+VVPIRVYR
Sbjct 121 WSPDSESSLEVLDYLLRSGVSGKRIAVQLHGAADGWDPFPEFVGGLRSAGAEVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP PLGG FD LV GIARRQFDAV+FTSAPAAAAVLER R+L IE+QLLAALR DVHAM
Sbjct 181 WKPTPLGGEFDQLVAGIARRQFDAVSFTSAPAAAAVLERGRQLGIEEQLLAALRNDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTSRPL RKGVPTSAPERMRLGALARHIAEELP GSCT AAGHVI+IRGT VLV
Sbjct 241 CVGPVTSRPLARKGVPTSAPERMRLGALARHIAEELPRRGSCTLTAAGHVIDIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
DDS+K L SGMAILRAL RPG VV R +LL VLPG+G DTHAVDTAVLRLRT LGDKN
Sbjct 301 DDSIKTLPASGMAILRALARRPGDVVGRDELLAVLPGNGEDTHAVDTAVLRLRTGLGDKN 360
Query 361 IVATVVKRGYRLAVDSR 377
I+ATVVKRGYRLAVD++
Sbjct 361 IIATVVKRGYRLAVDTQ 377
>gi|296167538|ref|ZP_06849890.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium parascrofulaceum ATCC BAA-614]
gi|295897160|gb|EFG76769.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium parascrofulaceum ATCC BAA-614]
Length=383
Score = 612 bits (1577), Expect = 4e-173, Method: Compositional matrix adjust.
Identities = 316/379 (84%), Positives = 341/379 (90%), Gaps = 0/379 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M Q S PLTGYRIAVTSARR+EELCALL R GAEVCSAPAI MIALPDDDEL NTEAL
Sbjct 1 MGQPDSPPLTGYRIAVTSARRSEELCALLSRHGAEVCSAPAINMIALPDDDELHRNTEAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA+PPDILVAHTGIGFRGWLAAAEGWGL N L+ +LSSARI+SRGPKATGALRAAGL EE
Sbjct 61 IAEPPDILVAHTGIGFRGWLAAAEGWGLVNPLVAALSSARIVSRGPKATGALRAAGLHEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP+SESS EVLEYLL SGV+ R+AVQLHGAAD+WDPFPEFLGGLR AGA+VVP+RVYR
Sbjct 121 WSPESESSQEVLEYLLRSGVTGLRVAVQLHGAADAWDPFPEFLGGLRLAGAEVVPVRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP PLGG FD LVTGIA RQFDAVTFTSAPAAAAVLERSRELD+ED+LL ALRTDVHAM
Sbjct 181 WKPTPLGGTFDQLVTGIAGRQFDAVTFTSAPAAAAVLERSRELDVEDELLGALRTDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTS+PLIRKGVPTS+PERMRLGALARH+AEELPLLGSCT +AAGH ++IRGT VLV
Sbjct 241 CVGPVTSKPLIRKGVPTSSPERMRLGALARHVAEELPLLGSCTVQAAGHTVDIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D S+K LSPSGM ILRAL RPG VV+RGDLLR LPG+ +D HAVDTAVLRLRTALGDKN
Sbjct 301 DGSIKVLSPSGMGILRALAKRPGDVVARGDLLRALPGNSNDPHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHD 379
I+ATVVKRGYRLA + R D
Sbjct 361 IIATVVKRGYRLATEQRAD 379
>gi|342859267|ref|ZP_08715921.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium colombiense CECT 3035]
gi|342133508|gb|EGT86711.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium colombiense CECT 3035]
Length=383
Score = 597 bits (1540), Expect = 8e-169, Method: Compositional matrix adjust.
Identities = 302/379 (80%), Positives = 330/379 (88%), Gaps = 0/379 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MA SAPLTGYRIAVTSA RAEELCALLRR GAEV SA AI +IALP+DDELQ++TEA+
Sbjct 1 MAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVSSAAAINIIALPEDDELQSHTEAV 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IADPPDILVAHTGIGFRGW+AAA+GWGLA +LL SL+ +RI++RGPKATGALRAAGL EE
Sbjct 61 IADPPDILVAHTGIGFRGWVAAADGWGLATQLLASLAKSRIVARGPKATGALRAAGLHEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP SESS EVL YLLES V+ RIAVQLHGAAD WDPFPEF+ GLR AGAQVVPI VYR
Sbjct 121 WSPKSESSREVLRYLLESDVAGKRIAVQLHGAADGWDPFPEFINGLRAAGAQVVPIHVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP P GG FDHLV +ARRQFDAVTFTSAPA AA+LERSREL IEDQLL ALR+DVHAM
Sbjct 181 WKPTPAGGDFDHLVASVARRQFDAVTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT++PLIR G+PTS+PERMRLGALARHIA+ELP L SCT +AAGH IEIRGT VLV
Sbjct 241 CVGPVTAQPLIRAGIPTSSPERMRLGALARHIAQELPPLRSCTIRAAGHDIEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D SVK LS SGMA LRAL RPG VV+R DLLRVLPG+ +D HAVDTAVLRLRTALGDKN
Sbjct 301 DGSVKALSGSGMATLRALAQRPGDVVARNDLLRVLPGNSNDPHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHD 379
I+ATVVKRGYRLA+D D
Sbjct 361 IIATVVKRGYRLAIDHSGD 379
>gi|183980548|ref|YP_001848839.1| transcriptional regulatory protein [Mycobacterium marinum M]
gi|183173874|gb|ACC38984.1| transcriptional regulatory protein [Mycobacterium marinum M]
Length=383
Score = 587 bits (1512), Expect = 1e-165, Method: Compositional matrix adjust.
Identities = 315/379 (84%), Positives = 342/379 (91%), Gaps = 0/379 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MAQ S PL GYRIAVTS+RRAEELCALLRR GA+VCSAPAI MIALP+DDELQ NTEAL
Sbjct 1 MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSAPAINMIALPEDDELQGNTEAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA+PPDILVAHTGIGFRGW+AAAEGWGLA EL+++LS R ISRGPKATG LRAAGLREE
Sbjct 61 IANPPDILVAHTGIGFRGWVAAAEGWGLAGELVDALSVGRTISRGPKATGELRAAGLREE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP+SESS EVLEYLLESGV+ RIA+QLHGAAD WDPFPEF+GGLR AGA+VVPIRVYR
Sbjct 121 WSPESESSQEVLEYLLESGVAGQRIAIQLHGAADGWDPFPEFVGGLRAAGAEVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP PLGG FD LVT IARRQFDAV+FTSAPAAAAVLER RELDIE++LL ALR DVHAM
Sbjct 181 WKPTPLGGAFDQLVTEIARRQFDAVSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTSRPLIRKGVPTS+PERMRLGALARHIAEELPLLGSCT AAGHV++IRGT VLV
Sbjct 241 CVGPVTSRPLIRKGVPTSSPERMRLGALARHIAEELPLLGSCTVNAAGHVVDIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D S+K LS SGMAILRAL RPG VV+R +LL VLPG+G DTHAVDTAVLRLRTALGDKN
Sbjct 301 DGSIKTLSGSGMAILRALTKRPGDVVARSELLNVLPGNGDDTHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHD 379
I+ATVVKRGYRLA+D++ D
Sbjct 361 IIATVVKRGYRLALDTQDD 379
>gi|41409804|ref|NP_962640.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium avium subsp. paratuberculosis
K-10]
gi|41398636|gb|AAS06256.1| hypothetical protein MAP_3706c [Mycobacterium avium subsp. paratuberculosis
K-10]
Length=383
Score = 586 bits (1511), Expect = 2e-165, Method: Compositional matrix adjust.
Identities = 296/376 (79%), Positives = 325/376 (87%), Gaps = 0/376 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MA SAPLTGYRIAVTSA RAEELCALLRR GAEV SA AI +IALP+D EL +TEA+
Sbjct 1 MAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVTSAAAINIIALPEDQELHRHTEAV 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA PPDILVAHTGIGFRGW+AAA+GWGLA +LL +LS ARI++RGPKATGALRAAGL EE
Sbjct 61 IAQPPDILVAHTGIGFRGWVAAADGWGLAPQLLSALSQARIVARGPKATGALRAAGLHEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP SESS EVL YLL+SGV+ RIAVQLHGAAD WDPFPEF+ GLR AGAQV+PI VYR
Sbjct 121 WSPKSESSREVLRYLLDSGVAGKRIAVQLHGAADGWDPFPEFINGLRSAGAQVMPIHVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP P GG FD LV +ARRQFDAVTFTSAPA AA+LERSREL IEDQLL ALR+DVHAM
Sbjct 181 WKPTPAGGEFDQLVASVARRQFDAVTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT++PLIR GVPTS+PERMRLGALARHIA+ELP L SCT +AAGH IEIRGT VLV
Sbjct 241 CVGPVTAQPLIRAGVPTSSPERMRLGALARHIAQELPPLRSCTLRAAGHQIEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D +VK LS S MA LRAL RPG VV+R DLLRVLPG+ +D HAVDTAVLRLRTALGDKN
Sbjct 301 DGAVKSLSGSAMATLRALAARPGDVVARNDLLRVLPGNSNDPHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDS 376
I+ATVVKRGYRLA+D+
Sbjct 361 IIATVVKRGYRLAIDT 376
>gi|254777340|ref|ZP_05218856.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium avium subsp. avium ATCC 25291]
gi|336460110|gb|EGO39016.1| uroporphyrinogen-III synthase [Mycobacterium avium subsp. paratuberculosis
S397]
Length=387
Score = 584 bits (1505), Expect = 8e-165, Method: Compositional matrix adjust.
Identities = 295/376 (79%), Positives = 325/376 (87%), Gaps = 0/376 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
+A SAPLTGYRIAVTSA RAEELCALLRR GAEV SA AI +IALP+D EL +TEA+
Sbjct 5 LAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVTSAAAINIIALPEDQELHRHTEAV 64
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA PPDILVAHTGIGFRGW+AAA+GWGLA +LL +LS ARI++RGPKATGALRAAGL EE
Sbjct 65 IAQPPDILVAHTGIGFRGWVAAADGWGLAPQLLSALSQARIVARGPKATGALRAAGLHEE 124
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP SESS EVL YLL+SGV+ RIAVQLHGAAD WDPFPEF+ GLR AGAQV+PI VYR
Sbjct 125 WSPKSESSREVLRYLLDSGVAGKRIAVQLHGAADGWDPFPEFINGLRSAGAQVMPIHVYR 184
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP P GG FD LV +ARRQFDAVTFTSAPA AA+LERSREL IEDQLL ALR+DVHAM
Sbjct 185 WKPTPAGGEFDQLVASVARRQFDAVTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAM 244
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT++PLIR GVPTS+PERMRLGALARHIA+ELP L SCT +AAGH IEIRGT VLV
Sbjct 245 CVGPVTAQPLIRAGVPTSSPERMRLGALARHIAQELPPLRSCTLRAAGHQIEIRGTCVLV 304
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D +VK LS S MA LRAL RPG VV+R DLLRVLPG+ +D HAVDTAVLRLRTALGDKN
Sbjct 305 DGAVKSLSGSAMATLRALAARPGDVVARNDLLRVLPGNSNDPHAVDTAVLRLRTALGDKN 364
Query 361 IVATVVKRGYRLAVDS 376
I+ATVVKRGYRLA+D+
Sbjct 365 IIATVVKRGYRLAIDT 380
>gi|118464556|ref|YP_884021.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium avium 104]
gi|118165843|gb|ABK66740.1| uroporphyrinogen-III synthetase [Mycobacterium avium 104]
Length=387
Score = 582 bits (1501), Expect = 3e-164, Method: Compositional matrix adjust.
Identities = 294/376 (79%), Positives = 324/376 (87%), Gaps = 0/376 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
+A SAPLTGYRIAVTSA RAEELCALLRR GAEV SA AI +IALP+D EL +TEA+
Sbjct 5 LAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVTSAAAINIIALPEDQELHRHTEAV 64
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
I PPDILVAHTGIGFRGW+AAA+GWGLA +LL +LS ARI++RGPKATGALRAAGL EE
Sbjct 65 ITQPPDILVAHTGIGFRGWVAAADGWGLAPQLLSALSQARIVARGPKATGALRAAGLHEE 124
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP SESS EVL YLL+SGV+ RIAVQLHGAAD WDPFPEF+ GLR AGAQV+PI VYR
Sbjct 125 WSPKSESSREVLRYLLDSGVAGKRIAVQLHGAADGWDPFPEFINGLRSAGAQVMPIHVYR 184
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP P GG FD LV +ARRQFDAVTFTSAPA AA+LERSREL IEDQLL ALR+DVHAM
Sbjct 185 WKPTPAGGEFDQLVASVARRQFDAVTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAM 244
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT++PLIR GVPTS+PERMRLGALARHIA+ELP L SCT +AAGH IEIRGT VLV
Sbjct 245 CVGPVTAQPLIRAGVPTSSPERMRLGALARHIAQELPPLRSCTLRAAGHQIEIRGTCVLV 304
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D +VK LS S MA LRAL RPG VV+R DLLRVLPG+ +D HAVDTAVLRLRTALGDKN
Sbjct 305 DGAVKSLSGSAMATLRALAARPGDVVARNDLLRVLPGNSNDPHAVDTAVLRLRTALGDKN 364
Query 361 IVATVVKRGYRLAVDS 376
I+ATVVKRGYRLA+D+
Sbjct 365 IIATVVKRGYRLAIDT 380
>gi|118616899|ref|YP_905231.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium ulcerans Agy99]
gi|118569009|gb|ABL03760.1| transcriptional regulatory protein [Mycobacterium ulcerans Agy99]
Length=383
Score = 582 bits (1499), Expect = 5e-164, Method: Compositional matrix adjust.
Identities = 313/379 (83%), Positives = 341/379 (90%), Gaps = 0/379 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
MAQ S PL GYRIAVTS+RRAEELCALLRR GA+VCSAPAI MIALP+DDELQ NTEAL
Sbjct 1 MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSAPAINMIALPEDDELQGNTEAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA+PPDILVAHTGIGFRGW+AAAEGWGLA EL+++LS R ISRGPKATG LRAAGLREE
Sbjct 61 IANPPDILVAHTGIGFRGWVAAAEGWGLAGELVDALSVGRTISRGPKATGELRAAGLREE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP+SESS EVLEYLLESGV+ RIA+QLHGAAD WDPFPEF+GGLR AGA+VVPIRV R
Sbjct 121 WSPESESSQEVLEYLLESGVAGQRIAIQLHGAADGWDPFPEFVGGLRAAGAEVVPIRVSR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP PLGG FD LVT IARRQFDAV+FTSAPAAAAVLER RELDIE++LL ALR DVHAM
Sbjct 181 WKPTPLGGAFDQLVTEIARRQFDAVSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVTSRPLIRKGVPTS+PER+RLGALARHIAEELPLLGSCT AAGHV++IRGT VLV
Sbjct 241 CVGPVTSRPLIRKGVPTSSPERLRLGALARHIAEELPLLGSCTVNAAGHVVDIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D S+K LS SGMAILRAL RPG VV+R +LL VLPG+G DTHAVDTAVLRLRTALGDKN
Sbjct 301 DGSIKTLSGSGMAILRALTKRPGDVVARSELLNVLPGNGDDTHAVDTAVLRLRTALGDKN 360
Query 361 IVATVVKRGYRLAVDSRHD 379
I+ATVVKRGYRLA+D++ D
Sbjct 361 IIATVVKRGYRLALDTQDD 379
>gi|254820412|ref|ZP_05225413.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium intracellulare ATCC 13950]
Length=387
Score = 580 bits (1496), Expect = 1e-163, Method: Compositional matrix adjust.
Identities = 293/375 (79%), Positives = 326/375 (87%), Gaps = 0/375 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
+A SAPLTGYRIAVTSA RAEELCALLRR GAEV SA AI +IALP+D+EL +TEA+
Sbjct 5 LAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVSSAAAINLIALPEDEELHRHTEAV 64
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA+PPDILVAHTGIGFRGW+AAA+GWGLA +LL SLS ARI++RGPKATGALRAAGL EE
Sbjct 65 IAEPPDILVAHTGIGFRGWVAAADGWGLATQLLASLSRARIVARGPKATGALRAAGLHEE 124
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP SESS EVL YLLES V+ R+AVQLHGAAD+WDPFPEFL GLR AGAQVVPI VYR
Sbjct 125 WSPRSESSSEVLRYLLESDVAGKRVAVQLHGAADTWDPFPEFLNGLRSAGAQVVPIHVYR 184
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
WKP P GG FD LVT +ARRQFDAVTFTSAPA AA+LERSREL +E+QLL ALR+DVHAM
Sbjct 185 WKPTPAGGDFDQLVTSVARRQFDAVTFTSAPAGAALLERSRELGVEEQLLQALRSDVHAM 244
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT++PL+R GVPTS+PERMRLGALARHIA+ELP L S T +AAGH +EIRGT VLV
Sbjct 245 CVGPVTAQPLLRAGVPTSSPERMRLGALARHIAQELPTLRSTTIRAAGHEMEIRGTCVLV 304
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D S + LS SGMA LRAL RPG VV+R DLLRVLPG+ +D HAVDTAVLRLRTALGDKN
Sbjct 305 DGSPRSLSGSGMATLRALAERPGDVVARNDLLRVLPGNSNDPHAVDTAVLRLRTALGDKN 364
Query 361 IVATVVKRGYRLAVD 375
I+ATVVKRGYRLA+D
Sbjct 365 IIATVVKRGYRLAID 379
>gi|118472313|ref|YP_884845.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium smegmatis str. MC2 155]
gi|118173600|gb|ABK74496.1| uroporphyrinogen-III synthetase [Mycobacterium smegmatis str.
MC2 155]
Length=385
Score = 556 bits (1433), Expect = 2e-156, Method: Compositional matrix adjust.
Identities = 280/375 (75%), Positives = 319/375 (86%), Gaps = 0/375 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M + APLTG+R+AVTSARRA+ELCALLRR+GA V SAPAI M+ LPDDDEL+ +TE+L
Sbjct 1 MREPDWAPLTGFRVAVTSARRADELCALLRRRGATVTSAPAITMVPLPDDDELRAHTESL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
I DPPDI+VA TGIG RGW+AAA+GWGLA EL E+L ARI+SRGPKATGALRAAGL EE
Sbjct 61 ITDPPDIVVATTGIGLRGWIAAADGWGLAGELTEALGKARIVSRGPKATGALRAAGLPEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESS EV+ YL+E GV RIAVQLHGA D WDPFPEFL LR AGA+VVPIRVYR
Sbjct 121 WSPDSESSREVVRYLVEHGVDGRRIAVQLHGATDDWDPFPEFLDELRVAGAEVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W PAP GG FD LV GIA R+FDAV+FTSAPA A+VL R+ EL + +Q+++ALRTDVHAM
Sbjct 181 WHPAPPGGEFDQLVAGIAERRFDAVSFTSAPAVASVLMRATELGLTEQVVSALRTDVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT+RPL+R G+PTSAPERMRLGALARHI +ELPLL S T + AGH++EIRGT VLV
Sbjct 241 CVGPVTARPLVRLGIPTSAPERMRLGALARHITDELPLLQSRTLRVAGHLLEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D VK LSP+GMA +RAL HRPG VVSR DLL LPG G+DTHAV+TAVLRLRTALGDK+
Sbjct 301 DGVVKSLSPAGMATIRALAHRPGAVVSRFDLLGALPGSGTDTHAVETAVLRLRTALGDKS 360
Query 361 IVATVVKRGYRLAVD 375
IV+TVVKRGYRLAVD
Sbjct 361 IVSTVVKRGYRLAVD 375
>gi|108797243|ref|YP_637440.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium sp. MCS]
gi|119866328|ref|YP_936280.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium sp. KMS]
gi|108767662|gb|ABG06384.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. MCS]
gi|119692417|gb|ABL89490.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. KMS]
Length=382
Score = 538 bits (1385), Expect = 8e-151, Method: Compositional matrix adjust.
Identities = 271/375 (73%), Positives = 313/375 (84%), Gaps = 0/375 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M++ APLTG+R+AVTSARRAEEL ALLRR+GA V SA AI M+ LPDDDEL+ +T+AL
Sbjct 1 MSEPDWAPLTGFRVAVTSARRAEELSALLRRRGATVTSAAAIAMVPLPDDDELRAHTQAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
I PPDI++A TGIG RGW+AAA+GWG+A EL +L+ ARI+SRGPKATGALRAAGL EE
Sbjct 61 IDAPPDIVIATTGIGLRGWIAAADGWGVAAELTAALAGARIVSRGPKATGALRAAGLPEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESS EVL YLL+ G++ RIAVQLHGA D WDPFPEFL LR AGA VVPIRVYR
Sbjct 121 WSPDSESSREVLRYLLDGGIADKRIAVQLHGATDDWDPFPEFLDELRAAGADVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W+PAP G FD LV GIA +FDAV+FTSAPA A+VL R+ E+ + D++L ALRT+VHAM
Sbjct 181 WRPAPRDGDFDQLVAGIAEEKFDAVSFTSAPAVASVLMRATEMGVADRVLTALRTNVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT+RPL+R GVPTSAPERMRLGALARHI +ELPLL + T + AGH++EIRGT VLV
Sbjct 241 CVGPVTARPLVRLGVPTSAPERMRLGALARHITDELPLLQARTVRVAGHLLEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D VK LSP+GMA +RAL HRPG VVSR DLL LPG G+DTHAV+TAVLRLRTALGDK
Sbjct 301 DGVVKSLSPAGMATIRALAHRPGAVVSRTDLLGALPGSGTDTHAVETAVLRLRTALGDKQ 360
Query 361 IVATVVKRGYRLAVD 375
IV+TVVKRGYRL VD
Sbjct 361 IVSTVVKRGYRLTVD 375
>gi|126432866|ref|YP_001068557.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium sp. JLS]
gi|126232666|gb|ABN96066.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. JLS]
Length=382
Score = 537 bits (1384), Expect = 1e-150, Method: Compositional matrix adjust.
Identities = 271/375 (73%), Positives = 313/375 (84%), Gaps = 0/375 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M++ APLTG+R+AVTSARRAEEL ALLRR+GA V SA AI M+ LPDDDEL+ +T+AL
Sbjct 1 MSEPDWAPLTGFRVAVTSARRAEELSALLRRRGATVTSAAAIAMVPLPDDDELRAHTQAL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
I PPDI++A TGIG RGW+AAA+GWG+A EL +L+ ARI+SRGPKATGALRAAGL EE
Sbjct 61 IDAPPDIVIATTGIGLRGWIAAADGWGVAAELTAALAGARIVSRGPKATGALRAAGLPEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSPDSESS EVL YLL+ G++ RIAVQLHGA D WDPFPEFL LR AGA VVPIRVYR
Sbjct 121 WSPDSESSREVLRYLLDGGIAGKRIAVQLHGATDDWDPFPEFLDELRAAGADVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W+PAP G FD LV GIA +FDAV+FTSAPA A+VL R+ E+ + D++L ALRT+VHAM
Sbjct 181 WRPAPRDGDFDQLVAGIAEEKFDAVSFTSAPAVASVLMRATEMGVADRVLTALRTNVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT+RPL+R GVPTSAPERMRLGALARHI +ELPLL + T + AGH++EIRGT VLV
Sbjct 241 CVGPVTARPLVRLGVPTSAPERMRLGALARHITDELPLLQARTVRVAGHLLEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D VK LSP+GMA +RAL HRPG VVSR DLL LPG G+DTHAV+TAVLRLRTALGDK
Sbjct 301 DGVVKSLSPAGMATIRALAHRPGAVVSRTDLLGALPGSGTDTHAVETAVLRLRTALGDKQ 360
Query 361 IVATVVKRGYRLAVD 375
IV+TVVKRGYRL VD
Sbjct 361 IVSTVVKRGYRLTVD 375
>gi|120401327|ref|YP_951156.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium vanbaalenii PYR-1]
gi|119954145|gb|ABM11150.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium vanbaalenii
PYR-1]
Length=380
Score = 518 bits (1334), Expect = 6e-145, Method: Compositional matrix adjust.
Identities = 270/375 (72%), Positives = 318/375 (85%), Gaps = 0/375 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M++ APLTG+R+AVTSARRA+EL ALLRR+GA VCSA AI+M+ LPDDDEL+ +T +L
Sbjct 1 MSEPDWAPLTGFRVAVTSARRADELSALLRRRGATVCSAAAIEMVPLPDDDELRQHTRSL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA PPDI++A TGIGFRGW+AAA+GWG+A EL +LS+ARI+SRGPKATGALRAAGL EE
Sbjct 61 IASPPDIVIATTGIGFRGWVAAADGWGMATELTAALSNARIVSRGPKATGALRAAGLPEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP+SESS E+L YL+E G++ TRIAVQLHGA WDPFPEFL LR AGA+VVPIRVYR
Sbjct 121 WSPESESSRELLHYLVEGGIAGTRIAVQLHGATADWDPFPEFLDELRAAGAEVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W PAP G FD LV GIA +FDAV+FTSAPA A+VL R+ E+ +E ++L+ALRT+VHAM
Sbjct 181 WHPAPRNGEFDQLVAGIADEKFDAVSFTSAPAVASVLLRATEMGLEAEVLSALRTNVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT+RPL+R GVPTSAPERMRLGALARHI +ELPLL + T + AGH++EIRGT VLV
Sbjct 241 CVGPVTARPLVRLGVPTSAPERMRLGALARHITDELPLLQTRTVRVAGHLLEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D +VK LSPS MA +RAL RPG VVSR DLLR LPG G+DTHAV+TAVLRLRTALGDK
Sbjct 301 DGTVKELSPSAMATIRALALRPGAVVSRVDLLRALPGSGTDTHAVETAVLRLRTALGDKK 360
Query 361 IVATVVKRGYRLAVD 375
+V+TVVKRGYRL VD
Sbjct 361 MVSTVVKRGYRLPVD 375
>gi|145220984|ref|YP_001131662.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium gilvum PYR-GCK]
gi|315442044|ref|YP_004074923.1| uroporphyrinogen-III synthase [Mycobacterium sp. Spyr1]
gi|145213470|gb|ABP42874.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium gilvum PYR-GCK]
gi|315260347|gb|ADT97088.1| uroporphyrinogen-III synthase [Mycobacterium sp. Spyr1]
Length=380
Score = 502 bits (1292), Expect = 5e-140, Method: Compositional matrix adjust.
Identities = 263/375 (71%), Positives = 311/375 (83%), Gaps = 0/375 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M APLTG+R+AVTSARRA+EL ALLRR+GA V SA AI+M+ LPDDDEL+ T++L
Sbjct 1 MTDPDWAPLTGFRVAVTSARRADELAALLRRRGATVTSAAAIEMVPLPDDDELRQRTQSL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
I PPDI++A TGIGFRGW+AAA+GWG+A +L +LS+ARI+SRGPKATGALRAAGL EE
Sbjct 61 IDAPPDIVIATTGIGFRGWVAAADGWGMAADLTTALSTARIVSRGPKATGALRAAGLPEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP+SESS E+L YL+E G++ TRIAVQLHGA WDPFPEFL LR AGA+VVPIRVYR
Sbjct 121 WSPESESSRELLHYLVEGGIAGTRIAVQLHGATAEWDPFPEFLDELRAAGAEVVPIRVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W PAP G FD LV GIA +FDAV+FTSAPA A+VL R+ E+ +E ++L+ALR VHAM
Sbjct 181 WHPAPRNGDFDQLVAGIAEEKFDAVSFTSAPAVASVLLRATEMGLEAEVLSALRNGVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT+RPL+R GVPTSAPERMRLGALARHI +ELPLL + T + AGH++EIRGT VLV
Sbjct 241 CVGPVTARPLVRLGVPTSAPERMRLGALARHITDELPLLQARTVRVAGHLLEIRGTCVLV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D +VK LSP+ MA +RAL +PG VVSR DLLR LPG G+DTHAV+TAVLRLR ALGDK
Sbjct 301 DGTVKALSPAAMATIRALALKPGAVVSRTDLLRALPGSGTDTHAVETAVLRLRAALGDKK 360
Query 361 IVATVVKRGYRLAVD 375
+V+TVVKRGYRL VD
Sbjct 361 MVSTVVKRGYRLPVD 375
>gi|333988881|ref|YP_004521495.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium sp. JDM601]
gi|333484848|gb|AEF34240.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Mycobacterium sp. JDM601]
Length=379
Score = 459 bits (1180), Expect = 4e-127, Method: Compositional matrix adjust.
Identities = 248/376 (66%), Positives = 289/376 (77%), Gaps = 0/376 (0%)
Query 1 MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
M + A L+GYR+AVTS+RRA+ELC LLRR GA VC+APAI M+ L DDDEL TE L
Sbjct 1 MTRPDRAALSGYRVAVTSSRRADELCTLLRRHGATVCAAPAIDMVDLTDDDELHCCTEEL 60
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA PPDILV T IGFRGW+AAAEGWGLA+EL+E+L +ARI++RGPKA GALRAA L EE
Sbjct 61 IARPPDILVVTTAIGFRGWIAAAEGWGLADELIEALHTARIVARGPKAVGALRAADLPEE 120
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP+SESS +L YL +GV IAVQLHG + WDP PE L LR AGA+V PI+VYR
Sbjct 121 WSPESESSAAMLGYLRAAGVCGHHIAVQLHGTSGGWDPAPELLDRLRCAGAEVTPIQVYR 180
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W+ A GG FD L T IA+RQFDAV+FTSA A A L R+ EL I D+LL ALR++VHAM
Sbjct 181 WRAARPGGEFDQLTTEIAQRQFDAVSFTSAAAVMATLTRAVELGISDELLGALRSEVHAM 240
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGP+T+RPL + GVPTS+P RMRLGALARHI ++LP L S AAGH IE+R + V+V
Sbjct 241 CVGPLTARPLTQLGVPTSSPRRMRLGALARHIVDQLPRLRSRAVYAAGHRIEVRSSCVMV 300
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D K +SP+GMA LRAL PG VVSR DLL LPG+G THAV+TAVLRLR LGDKN
Sbjct 301 DGVAKAVSPAGMATLRALARHPGKVVSRDDLLDALPGNGRSTHAVETAVLRLRNTLGDKN 360
Query 361 IVATVVKRGYRLAVDS 376
I+ATVVKRGYRLAVD
Sbjct 361 IIATVVKRGYRLAVDQ 376
>gi|54026532|ref|YP_120774.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Nocardia farcinica IFM 10152]
gi|54018040|dbj|BAD59410.1| hypothetical protein [Nocardia farcinica IFM 10152]
Length=412
Score = 404 bits (1037), Expect = 2e-110, Method: Compositional matrix adjust.
Identities = 211/370 (58%), Positives = 261/370 (71%), Gaps = 1/370 (0%)
Query 7 APLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPD 66
APL G+ + +T+ARRAEE LL R+GA + SAPAI++I L DD EL+ T L+A+PP
Sbjct 8 APLAGFTVGITAARRAEEFATLLTRRGATIVSAPAIRIIPLADDTELERVTRTLVAEPPQ 67
Query 67 ILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSE 126
I VA TGIGFRGW+ AAEGWGLA L +L+ R+++RGPKA GA+RAA LREEWSP SE
Sbjct 68 IAVATTGIGFRGWMEAAEGWGLAEYLRGTLAGTRLLARGPKAKGAIRAAELREEWSPASE 127
Query 127 SSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPL 186
SS EVL++LL GV RIAVQLHGA W+P P+F LR AGA VVP+ VYRW P
Sbjct 128 SSAEVLDHLLAEGVEGVRIAVQLHGATTEWEPVPDFCEVLRCAGADVVPVPVYRWIPPAD 187
Query 187 GGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVT 246
G D L+ I D VTFTSAPA A++L R++E + + +L ALRT V CVGP+T
Sbjct 188 QGPMDQLIEAIVTASLDCVTFTSAPAVASMLMRAKETGLLEGVLHALRTRVLPACVGPIT 247
Query 247 SRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKP 306
+ PL GVPTS P R RLGALARH+AEELP + +AAGH I +RG V+VD V+
Sbjct 248 AAPLEELGVPTSMPGRARLGALARHVAEELPRRAN-RIQAAGHTISVRGGCVVVDGQVRQ 306
Query 307 LSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVV 366
L+P+ MA++R+L +PG VVSR DLL LPG G DTHAV+TA+ RLR LG + TVV
Sbjct 307 LAPAPMALMRSLARQPGRVVSREDLLAALPGGGEDTHAVETAIARLRAGLGTPKAIQTVV 366
Query 367 KRGYRLAVDS 376
KRGYRLA+D+
Sbjct 367 KRGYRLALDT 376
>gi|333921413|ref|YP_004494994.1| hypothetical protein AS9A_3756 [Amycolicicoccus subflavus DQS3-9A1]
gi|333483634|gb|AEF42194.1| hypothetical protein AS9A_3756 [Amycolicicoccus subflavus DQS3-9A1]
Length=388
Score = 402 bits (1032), Expect = 7e-110, Method: Compositional matrix adjust.
Identities = 213/374 (57%), Positives = 266/374 (72%), Gaps = 1/374 (0%)
Query 7 APLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPD 66
A L G+ I +T+ARRAEE LL R+GA + APAI++I+L DD EL+ TE++IA PPD
Sbjct 11 AALAGFTIGITAARRAEEFATLLSRRGATLVHAPAIRIISLVDDTELRKATESVIASPPD 70
Query 67 ILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSE 126
I VA TGIGFRGW+ AA+ WGLA LL +L+S+R+++RGPKA GA+RAAGLREEWSPDSE
Sbjct 71 IAVATTGIGFRGWVEAADNWGLAEPLLNALTSSRLLARGPKAKGAMRAAGLREEWSPDSE 130
Query 127 SSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPL 186
SS EVL++LLE GV RIAVQLHGA W+P P+F +R AGA+VVP+ VYRW P
Sbjct 131 SSAEVLDHLLEEGVEGKRIAVQLHGATTEWEPIPDFCEVMRSAGAEVVPVPVYRWVPPDD 190
Query 187 GGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVT 246
D ++ + DA+TFTSAPA A++L R++E + + LL ALR V VGPVT
Sbjct 191 RSQLDRMIEMSINGELDAITFTSAPAVASLLGRAKETRVLESLLNALRGRVVPFSVGPVT 250
Query 247 SRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKP 306
+ PL GV T+ P R RLGALARHIAEELP + +A G + IRG+ ++VD VK
Sbjct 251 AAPLEALGVATTQPHRARLGALARHIAEELPRRAN-HLQAGGSHLSIRGSCIVVDREVKQ 309
Query 307 LSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVV 366
+ P+ ++I+RAL RPG VVSR DLL VLPG G DTHAV+TAV RLR ALG +V TVV
Sbjct 310 VPPASLSIMRALARRPGAVVSREDLLAVLPGAGGDTHAVETAVARLRAALGAPKVVQTVV 369
Query 367 KRGYRLAVDSRHDD 380
KRGYRLA+D D
Sbjct 370 KRGYRLALDPVESD 383
>gi|317507942|ref|ZP_07965637.1| uroporphyrinogen-III synthase HemD [Segniliparus rugosus ATCC
BAA-974]
gi|316253753|gb|EFV13128.1| uroporphyrinogen-III synthase HemD [Segniliparus rugosus ATCC
BAA-974]
Length=395
Score = 401 bits (1031), Expect = 7e-110, Method: Compositional matrix adjust.
Identities = 212/372 (57%), Positives = 264/372 (71%), Gaps = 1/372 (0%)
Query 9 LTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDIL 68
L+GY + VT+ARRA+EL ALL R+G V APAI +I L DD EL+ + +IADPPD++
Sbjct 17 LSGYTVGVTAARRADELTALLTRRGGAVLHAPAIVIIPLADDAELERMSREIIADPPDVV 76
Query 69 VAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESS 128
VA TGIGFRGWL AAEGWG+A EL +L ++R+++RGPKATGA+RAAGLRE WSP SESS
Sbjct 77 VATTGIGFRGWLEAAEGWGVAEELRTALQNSRLVARGPKATGAIRAAGLREVWSPCSESS 136
Query 129 HEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGG 188
EVLE LL GV R+AVQLHGA ++P P+F LR AGAQV+P+ VYRW+P
Sbjct 137 SEVLERLLAEGVEGLRVAVQLHGATTEFEPLPDFSEALRHAGAQVLPVPVYRWEPPSDQS 196
Query 189 VFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSR 248
D L+ +A D V+FTSAPA A++L R++E ++ DQLL+ R+ V A+CVGPVT+
Sbjct 197 AMDTLIAAVANGTVDGVSFTSAPAVASMLGRAKETNMLDQLLSGFRSHVAALCVGPVTAA 256
Query 249 PLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLS 308
PL GVPT+AP R RLGALARHI EELP F A GH I + SV+VD V+ L+
Sbjct 257 PLEALGVPTTAPSRSRLGALARHIEEELPRRAKV-FPAHGHKIAVLARSVVVDGEVRHLA 315
Query 309 PSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKR 368
PS + ++R L +PG VV+R LL LPG +D HAV+ A+ RLRT LGD IV TVVKR
Sbjct 316 PSMLTLMRELARQPGRVVTRETLLASLPGHSADAHAVEAAIGRLRTGLGDPKIVQTVVKR 375
Query 369 GYRLAVDSRHDD 380
GYRLAVD DD
Sbjct 376 GYRLAVDLGVDD 387
>gi|226305696|ref|YP_002765656.1| hypothetical protein RER_22090 [Rhodococcus erythropolis PR4]
gi|226184813|dbj|BAH32917.1| conserved hypothetical protein [Rhodococcus erythropolis PR4]
Length=386
Score = 386 bits (992), Expect = 3e-105, Method: Compositional matrix adjust.
Identities = 207/368 (57%), Positives = 258/368 (71%), Gaps = 1/368 (0%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + +T++RRAEE LL R+GA+V APAI++I L DD EL+ T+ +I+DPP++
Sbjct 6 PLAGFTVGITASRRAEEFATLLTRRGADVVHAPAIRIIPLADDRELERVTQQIISDPPEV 65
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
+VA TGIGFRGWL AA+GWG A L +L SAR+++RGPKA GA+RAA LREEWSP SES
Sbjct 66 VVATTGIGFRGWLEAADGWGEAENLGSALGSARLLARGPKAKGAIRAADLREEWSPASES 125
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
S EVLE+LL GVS RIAVQLHGA W+P P+F LR AGA+V+ + VYRW+P
Sbjct 126 SAEVLEHLLAEGVSGKRIAVQLHGATTEWEPIPDFCQVLRDAGAEVIAVPVYRWEPPEDP 185
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
+ D ++ IA DAV+FTSAPA A++L R+ + +L A+R V AMCVGPVTS
Sbjct 186 TLLDRMIDAIASAGIDAVSFTSAPAVASMLMRADKTGDLGDILDAMRGPVAAMCVGPVTS 245
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL VPT+AP R RLGALARHI +ELP + +A H I IRG V+VD VK L
Sbjct 246 APLEALNVPTTAPARARLGALARHIVDELPQRAN-KIQAGEHEISIRGGCVVVDGEVKQL 304
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+ M+++R L PG VVSR +LL LPG G DTHAV+TAV RLR LG V TVVK
Sbjct 305 PPAAMSLIRTLGASPGRVVSRDELLASLPGGGGDTHAVETAVARLRACLGAPKAVQTVVK 364
Query 368 RGYRLAVD 375
RGYRLA+D
Sbjct 365 RGYRLALD 372
>gi|229490999|ref|ZP_04384832.1| uroporphyrinogen-III synthetase [Rhodococcus erythropolis SK121]
gi|229322115|gb|EEN87903.1| uroporphyrinogen-III synthetase [Rhodococcus erythropolis SK121]
Length=386
Score = 386 bits (992), Expect = 3e-105, Method: Compositional matrix adjust.
Identities = 207/368 (57%), Positives = 258/368 (71%), Gaps = 1/368 (0%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + +T++RRAEE LL R+GA+V APAI++I L DD EL+ T+ +I+DPP++
Sbjct 6 PLAGFTVGITASRRAEEFATLLTRRGADVVHAPAIRIIPLADDRELERVTQQIISDPPEV 65
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
+VA TGIGFRGWL AA+GWG A L +L SAR+++RGPKA GA+RAA LREEWSP SES
Sbjct 66 VVATTGIGFRGWLEAADGWGEAENLGSALGSARLLARGPKAKGAIRAADLREEWSPASES 125
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
S EVLE+LL GVS RIAVQLHGA W+P P+F LR AGA+V+ + VYRW+P
Sbjct 126 SAEVLEHLLAEGVSGKRIAVQLHGATTEWEPIPDFCQVLREAGAEVIAVPVYRWEPPEDP 185
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
+ D ++ IA DAV+FTSAPA A++L R+ + +L A+R V AMCVGPVTS
Sbjct 186 TLLDRMIDAIASAGIDAVSFTSAPAVASMLMRADKTGDLGDILDAMRGPVAAMCVGPVTS 245
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL VPT+AP R RLGALARHI +ELP + +A H I IRG V+VD VK L
Sbjct 246 APLEALNVPTTAPARARLGALARHIVDELPQRAN-KIQAGEHEISIRGGCVVVDGEVKQL 304
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+ M+++R L PG VVSR +LL LPG G DTHAV+TAV RLR LG V TVVK
Sbjct 305 PPAAMSLIRTLGASPGRVVSRDELLASLPGGGGDTHAVETAVARLRACLGAPKAVQTVVK 364
Query 368 RGYRLAVD 375
RGYRLA+D
Sbjct 365 RGYRLALD 372
>gi|169630601|ref|YP_001704250.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Mycobacterium abscessus ATCC 19977]
gi|169242568|emb|CAM63596.1| Possible transcriptional regulatory protein [Mycobacterium abscessus]
Length=384
Score = 386 bits (992), Expect = 3e-105, Method: Compositional matrix adjust.
Identities = 204/367 (56%), Positives = 260/367 (71%), Gaps = 1/367 (0%)
Query 9 LTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDIL 68
L G+ I VT+ARR+EEL ALL R+GA V A AI++I L DD EL++ TE +IA+PPD+
Sbjct 10 LDGFTIGVTAARRSEELIALLERRGAAVVHAAAIRIIPLADDAELRDATELVIANPPDLT 69
Query 69 VAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESS 128
VA TGIGFRGW+ AA+ WG+A+ L +L S R+++RGPKATGA+R AGLREEWSP SESS
Sbjct 70 VATTGIGFRGWIEAADEWGVADGLKSALESGRLVARGPKATGAIRQAGLREEWSPASESS 129
Query 129 HEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGG 188
EVL+ LLE GV RIAVQLHGAA W+P + L AGAQV+ + VYRW+P
Sbjct 130 AEVLDRLLEEGVEGRRIAVQLHGAATEWEPIADLCEALTIAGAQVIRVPVYRWEPPEDQR 189
Query 189 VFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSR 248
D L++ + D ++FTSAPA A++L R++ D+LLAALR V +CVGPVT+
Sbjct 190 PMDRLISMAINAELDGISFTSAPAVASMLGRAKATGRLDELLAALRARVAPLCVGPVTAA 249
Query 249 PLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLS 308
PL GVPT+ PER RLGALARHIA+EL F A GH++ +R + VD + +S
Sbjct 250 PLEVLGVPTTQPERARLGALARHIADELTRRAP-RFHAGGHIVSVRSCGIAVDGETRQIS 308
Query 309 PSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKR 368
P+GMA+++ L+ RPG VVSR DLL LPG G DTHAV+TA+ RLR ALG ++ TVVKR
Sbjct 309 PAGMALMKRLMVRPGQVVSREDLLAALPGGGDDTHAVETAMTRLRAALGAPKVIQTVVKR 368
Query 369 GYRLAVD 375
GYRLA+D
Sbjct 369 GYRLAID 375
>gi|296139101|ref|YP_003646344.1| uroporphyrinogen III synthase HEM4 [Tsukamurella paurometabola
DSM 20162]
gi|296027235|gb|ADG78005.1| Uroporphyrinogen III synthase HEM4 [Tsukamurella paurometabola
DSM 20162]
Length=378
Score = 382 bits (980), Expect = 7e-104, Method: Compositional matrix adjust.
Identities = 211/374 (57%), Positives = 263/374 (71%), Gaps = 5/374 (1%)
Query 3 QAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIA 62
+A + PL G+ +AVT+ARRA+EL LL R+GA V +APAI M+ L DD L+ T+ L+
Sbjct 7 EASATPLLGFTVAVTAARRADELSTLLIRRGAAVVAAPAISMVPLSDDVRLRAATDELLT 66
Query 63 DPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWS 122
PPD+LVA TGIGFRGWL AAEGWG+A L+ +L R+ISRGPKATGALRAAGLREEWS
Sbjct 67 APPDLLVATTGIGFRGWLEAAEGWGVAEGLVAALGGGRVISRGPKATGALRAAGLREEWS 126
Query 123 PDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRW- 181
P SESS EVL +L + R+AVQLHGA D WDP P L GLR GA++VP+ VYRW
Sbjct 127 PKSESSAEVLSHLAGEDLHGQRVAVQLHGATDDWDPNPGLLDGLRDLGAEIVPVPVYRWE 186
Query 182 KPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMC 241
+P L G D +V IA + DAVTFTSAPAAA++LER+ EL + D + AAL V A C
Sbjct 187 QPEDLSG-LDRIVEAIALAEVDAVTFTSAPAAASLLERAVELGVADSVRAALTGPVVAYC 245
Query 242 VGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVD 301
VGPVT+ PL R+G+ + PERMRLGALAR + ++LP + AGH + +R +VD
Sbjct 246 VGPVTATPLQREGIESVTPERMRLGALARLVEQDLPGR-RPDLRVAGHSLGLRARGAVVD 304
Query 302 DSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNI 361
+ + L+P+ + +LR L PG VVSR +LL L GD D HAV+ AV RLRT LG K I
Sbjct 305 GAERDLTPTSITLLRLLAREPGDVVSRDELLAALGGD--DPHAVEAAVARLRTGLGHKEI 362
Query 362 VATVVKRGYRLAVD 375
+ATVVKRGYRLA+D
Sbjct 363 IATVVKRGYRLALD 376
>gi|296392987|ref|YP_003657871.1| uroporphyrinogen III synthase HEM4 [Segniliparus rotundus DSM
44985]
gi|296180134|gb|ADG97040.1| Uroporphyrinogen III synthase HEM4 [Segniliparus rotundus DSM
44985]
Length=402
Score = 376 bits (966), Expect = 3e-102, Method: Compositional matrix adjust.
Identities = 209/372 (57%), Positives = 260/372 (70%), Gaps = 1/372 (0%)
Query 9 LTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDIL 68
L+GY + VT+ARRA+E ALL R+GA V APAI +I L DD EL+ + +I +PPD+
Sbjct 24 LSGYTVGVTAARRADEFAALLTRRGAVVLHAPAIVIIPLADDAELERVSREIIQNPPDVA 83
Query 69 VAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESS 128
VA TGIGFRGWL AAEGWG+A EL +L +R+++RGPKATGA+RAAGLRE WSP SESS
Sbjct 84 VATTGIGFRGWLEAAEGWGVAEELRNALQGSRLVARGPKATGAIRAAGLREAWSPSSESS 143
Query 129 HEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGG 188
EVLE LLE GV R+AVQLHGA ++P P+F L+ AGAQV+ + VYRW+P
Sbjct 144 SEVLERLLEEGVQGLRVAVQLHGATTEFEPLPDFSEALQAAGAQVLAVPVYRWEPPHDQS 203
Query 189 VFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSR 248
D L+ +A+ D V+FTSAPA A++L R++E + +QLL R V A+CVGPVT+
Sbjct 204 AMDALIAAVAQGTVDGVSFTSAPAVASMLGRAKETGMFEQLLDGFRAQVAALCVGPVTAA 263
Query 249 PLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLS 308
PL GVPTSAP R RLGALARHI EELP F+A GH I + +V+VD V+ L+
Sbjct 264 PLEALGVPTSAPARSRLGALARHIEEELPRRAKV-FRAHGHTIAVLARAVVVDGEVRHLA 322
Query 309 PSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKR 368
PS + +LRAL +PG VV+R LL LPG +D HAV+ A+ RLRT LGD IV TVVKR
Sbjct 323 PSMLTLLRALARQPGRVVTREALLASLPGHSADAHAVEAAIGRLRTGLGDPKIVQTVVKR 382
Query 369 GYRLAVDSRHDD 380
GYRLA D DD
Sbjct 383 GYRLAADWGVDD 394
>gi|226365838|ref|YP_002783621.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Rhodococcus opacus B4]
gi|226244328|dbj|BAH54676.1| hypothetical protein [Rhodococcus opacus B4]
Length=385
Score = 376 bits (966), Expect = 3e-102, Method: Compositional matrix adjust.
Identities = 202/370 (55%), Positives = 257/370 (70%), Gaps = 1/370 (0%)
Query 6 SAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPP 65
+APL G+ I +T++RRAEE LL R+GA V APAI++I L DD EL+ T +I +PP
Sbjct 4 AAPLCGFTIGITASRRAEEFATLLTRRGATVVHAPAIRIIPLADDTELERVTRQIIDNPP 63
Query 66 DILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDS 125
+I+VA TGIGFRGW+ AA+GWG A EL +L+S+R+++RGPKA GA+RAA LREEWSP S
Sbjct 64 EIVVATTGIGFRGWMEAADGWGEAEELGRALASSRLLARGPKAKGAIRAADLREEWSPAS 123
Query 126 ESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAP 185
ESS EVL++LL GV RIAVQLHGA W+P +F LR AGA V+ + VYRW P
Sbjct 124 ESSAEVLDHLLGEGVEGKRIAVQLHGATTEWEPVADFCEVLRCAGADVIAVPVYRWTPLE 183
Query 186 LGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPV 245
D ++ IA DAV+FTSAPA A++L R++E + + +L + R V A CVGPV
Sbjct 184 DQAPMDRMIELIASGGLDAVSFTSAPAVASLLTRAKETGMIEMVLHSFRHRVLAACVGPV 243
Query 246 TSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVK 305
T+ PL VPT+ P R RLGALARHIA+ELP + + AGH + IRG V+VD V+
Sbjct 244 TAGPLRELEVPTTMPARSRLGALARHIADELPRRAN-KIQTAGHELSIRGGCVVVDGEVR 302
Query 306 PLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATV 365
L P+ M+++R L RPG VV R +LL LPG G DTHAV+TAV RLR +LG V TV
Sbjct 303 QLPPAAMSLMRTLGARPGRVVPRDELLAALPGGGGDTHAVETAVARLRASLGAPKAVQTV 362
Query 366 VKRGYRLAVD 375
VKRGYRLA+D
Sbjct 363 VKRGYRLALD 372
>gi|302551781|ref|ZP_07304123.1| uroporphyrinogen-III synthase [Streptomyces viridochromogenes
DSM 40736]
gi|302469399|gb|EFL32492.1| uroporphyrinogen-III synthase [Streptomyces viridochromogenes
DSM 40736]
Length=383
Score = 375 bits (964), Expect = 5e-102, Method: Compositional matrix adjust.
Identities = 206/369 (56%), Positives = 259/369 (71%), Gaps = 8/369 (2%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + VT+ARRA+EL ALL+R+GA V APA++++ L DD EL T+ +I PDI
Sbjct 12 PLAGFTVGVTAARRADELGALLQRRGAAVLHAPALRIVPLADDTELLAATKEIIQQVPDI 71
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
+VA T IGFRGW+ AA+GWGL ++LL L ARI++RGPK GA+RAAGL EEWSP SES
Sbjct 72 VVATTAIGFRGWVEAADGWGLGDDLLSRLGGARIMARGPKVKGAVRAAGLTEEWSPSSES 131
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
EVL+ LLE GV +RIA+QLHG +P P F+ LR GA+VV + VYRW P
Sbjct 132 MAEVLDRLLEEGVEGSRIAIQLHG-----EPLPGFVEALREGGAEVVGVPVYRWMPPEDI 186
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
G D L+ + R DA+TFTSAPAAA++L R+ E + ++LAAL DV CVGPVT+
Sbjct 187 GPVDRLLDAMVSRGLDALTFTSAPAAASLLSRAGERGLLPEILAALGHDVLPACVGPVTA 246
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSC-TFKAAGHVIEIRGTSVLVDDSVKP 306
PL GV T PER RLG L + + +ELP G T AGH +EIRG +VLVD +KP
Sbjct 247 LPLQAHGVDTVQPERFRLGPLVQLLCQELP--GRARTLPVAGHRVEIRGHAVLVDGDLKP 304
Query 307 LSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVV 366
+ P+GM++LRAL RPG VV+RGDLLR LPG G D HAV+TA+ RLRTALG ++ TVV
Sbjct 305 VPPAGMSLLRALARRPGWVVARGDLLRALPGAGRDEHAVETAMARLRTALGTPKLIQTVV 364
Query 367 KRGYRLAVD 375
KRGYRLA+D
Sbjct 365 KRGYRLALD 373
>gi|262203383|ref|YP_003274591.1| uroporphyrinogen III synthase HEM4 [Gordonia bronchialis DSM
43247]
gi|262086730|gb|ACY22698.1| Uroporphyrinogen III synthase HEM4 [Gordonia bronchialis DSM
43247]
Length=377
Score = 374 bits (960), Expect = 1e-101, Method: Compositional matrix adjust.
Identities = 214/372 (58%), Positives = 263/372 (71%), Gaps = 1/372 (0%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ I VT+ARRA+E ALL R+GA+V AP I+++ L DD EL+ T LIADPP+I
Sbjct 3 PLAGFTIGVTAARRADEFAALLVRRGAQVMHAPTIRILPLLDDTELERVTTELIADPPEI 62
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
+VA TGIGFRGW+ AA+GWG A ++L +L +R+I+RGPKA GA+RAAGLREEWSP+SES
Sbjct 63 MVATTGIGFRGWVEAADGWGNAEDVLAALGKSRLIARGPKAKGAIRAAGLREEWSPESES 122
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
S EVL+ LL GV RIAVQLHGA W+P P+F LR AGAQVVPI VYRW P
Sbjct 123 SSEVLDRLLAEGVDGVRIAVQLHGATSEWEPLPDFCTVLRAAGAQVVPIPVYRWNMHPDV 182
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
D ++ + R DA+TFTSAPAAAA+L R+++L Q + ALRT V MCVG VT+
Sbjct 183 DSIDKMIMAVVRGDLDALTFTSAPAAAAILTRAKQLGKLQQFIHALRTAVPVMCVGSVTA 242
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL +PT P R RLGALAR I +ELP S + AGH IRG +VLVD SV+ L
Sbjct 243 SPLEALQIPTIYPRRFRLGALARLITDELP-RRSHVLRVAGHDTAIRGQAVLVDGSVREL 301
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
S + + +L+ L PG VVSR +LL LPGD SDTHAV+ AV RLR+ALGD ++ TVVK
Sbjct 302 SATSLILLKILAGVPGRVVSRQELLGGLPGDSSDTHAVEVAVARLRSALGDPKMIQTVVK 361
Query 368 RGYRLAVDSRHD 379
RGYRLAVD +D
Sbjct 362 RGYRLAVDLEYD 373
>gi|111023331|ref|YP_706303.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Rhodococcus jostii RHA1]
gi|110822861|gb|ABG98145.1| possible transcriptional regulator [Rhodococcus jostii RHA1]
Length=385
Score = 373 bits (957), Expect = 3e-101, Method: Compositional matrix adjust.
Identities = 200/368 (55%), Positives = 255/368 (70%), Gaps = 1/368 (0%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ I +T++RRAEE LL R+GA V APAI++I L DD EL+ T +I +PP+I
Sbjct 6 PLCGFTIGITASRRAEEFATLLTRRGATVVHAPAIRIIPLADDTELERVTRQIIDNPPEI 65
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
+VA TGIGFRGW+ AA+GWG A EL +L+++R+++RGPKA GA+RAA LREEWSP SES
Sbjct 66 VVATTGIGFRGWMEAADGWGEAEELGRALAASRLLARGPKAKGAIRAADLREEWSPASES 125
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
S EVL++LL GV RIAVQLHGA W+P +F LR AGA V+ + VYRW P
Sbjct 126 SAEVLDHLLGEGVEGKRIAVQLHGATTEWEPVADFCEVLRCAGADVIAVPVYRWTPLEDQ 185
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
D ++ IA DAV+FTSAPA A++L R++E + + +L + R V A CVGPVT+
Sbjct 186 APMDRMIELIASGGLDAVSFTSAPAVASLLTRAKETGMIEMVLHSFRHRVLAACVGPVTA 245
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL VPT+ P R RLGALARHIA+ELP + + AGH + IRG V+VD V+ L
Sbjct 246 GPLRELEVPTTMPARSRLGALARHIADELPRRAN-KIQTAGHELSIRGGCVVVDGEVRQL 304
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+ M+++R L RPG VV R +LL LPG G DTHAV+TAV RLR +LG V TVVK
Sbjct 305 PPAAMSLIRTLGARPGRVVPRDELLAALPGGGGDTHAVETAVARLRASLGAPKAVQTVVK 364
Query 368 RGYRLAVD 375
RGYRLA+D
Sbjct 365 RGYRLALD 372
>gi|297194081|ref|ZP_06911479.1| uroporphyrinogen-III synthetase [Streptomyces pristinaespiralis
ATCC 25486]
gi|197720917|gb|EDY64825.1| uroporphyrinogen-III synthetase [Streptomyces pristinaespiralis
ATCC 25486]
Length=386
Score = 372 bits (954), Expect = 7e-101, Method: Compositional matrix adjust.
Identities = 208/377 (56%), Positives = 258/377 (69%), Gaps = 7/377 (1%)
Query 3 QAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIA 62
Q H PL G+ + VT+ARRA+EL ALL+R+GA V APA++++ L DD EL T+ LI
Sbjct 11 QPHG-PLAGFTVGVTAARRADELGALLQRRGAAVLHAPALRIVPLADDTELLAATKELID 69
Query 63 DPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWS 122
PD++VA T IGFRGW+ AA+GWGL +LL L A +++RGPK GA+RAAGL EEWS
Sbjct 70 HTPDVVVATTAIGFRGWVEAADGWGLGEQLLGRLRDAELLARGPKVKGAIRAAGLTEEWS 129
Query 123 PDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWK 182
P SES EVL+ LL GV+ R+A+QLHG +P P F+ LR AGA VV + VYRW
Sbjct 130 PASESMAEVLDRLLGEGVAGRRVALQLHG-----EPLPGFVESLREAGADVVLVPVYRWM 184
Query 183 PAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCV 242
P D L+ R DAVTFTSAPAAA++L R+ + +LLAAL DV A CV
Sbjct 185 PPEDLAPLDRLLDAAVSRGLDAVTFTSAPAAASLLNRAETRGLLTELLAALDHDVLAACV 244
Query 243 GPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDD 302
GPVT+ PL GVPT PER RLG L + + ELP + TF AGH +EIRG +VLVDD
Sbjct 245 GPVTAVPLQAAGVPTVQPERFRLGPLVQLLGVELPAR-ARTFPVAGHRVEIRGHAVLVDD 303
Query 303 SVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIV 362
++P+ P+GMA+LRAL RPG VV+R DLLR LPG G D HAV+TA+ RLRTALG ++
Sbjct 304 DLRPVPPAGMALLRALSERPGWVVARSDLLRALPGAGRDEHAVETAMARLRTALGAPKLI 363
Query 363 ATVVKRGYRLAVDSRHD 379
TVVKRGYRLA+D D
Sbjct 364 QTVVKRGYRLALDPASD 380
>gi|291453788|ref|ZP_06593178.1| conserved hypothetical protein [Streptomyces albus J1074]
gi|291356737|gb|EFE83639.1| conserved hypothetical protein [Streptomyces albus J1074]
Length=390
Score = 370 bits (950), Expect = 2e-100, Method: Compositional matrix adjust.
Identities = 199/371 (54%), Positives = 254/371 (69%), Gaps = 6/371 (1%)
Query 5 HSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADP 64
++PL G+ + VT+ RRA+EL ALL R+GAEV APA++++ L DD EL+ TE L+A P
Sbjct 22 EASPLVGFTVGVTAERRAQELGALLGRRGAEVVYAPALRVVPLADDRELREATEELVARP 81
Query 65 PDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPD 124
P+I+VA T +GFRGW+ AAEGWG+ L E+L AR+++RGPK TGA+RAAGLREEWSP
Sbjct 82 PEIVVASTAVGFRGWVEAAEGWGVGGALREALGGARLLARGPKVTGAVRAAGLREEWSPR 141
Query 125 SESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPA 184
SE+ EV E LL GV+ R+AVQLHG +P P F LR AGA+VV + VYRW P
Sbjct 142 SEAMEEVRERLLADGVAGLRVAVQLHG-----EPVPGFAEALRAAGAEVVGVPVYRWLPP 196
Query 185 PLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGP 244
D LV RR DA+TFTSAPA +VL R+ L + + L+ A+ DV +CVGP
Sbjct 197 ADLTPVDRLVDATVRRTLDALTFTSAPAVVSVLRRAEALGLREALVDAVNGDVAVVCVGP 256
Query 245 VTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSV 304
VT+RPL GV PER RLG + + + EELP + AGH +++RG +VLVD
Sbjct 257 VTARPLQEAGVEPVQPERYRLGPMVQRLCEELPAR-TPELAVAGHRVQLRGHAVLVDGEA 315
Query 305 KPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVAT 364
+P+ P+ MA+LRAL RPG VV+R +LLR LPG G D HAV++A RLRTALG +V T
Sbjct 316 RPVPPAPMALLRALARRPGRVVARAELLRALPGAGRDEHAVESATARLRTALGAPELVRT 375
Query 365 VVKRGYRLAVD 375
VVKRGYRLAVD
Sbjct 376 VVKRGYRLAVD 386
>gi|312140629|ref|YP_004007965.1| transcriptional regulator [Rhodococcus equi 103S]
gi|325675743|ref|ZP_08155427.1| uroporphyrinogen-III synthase domain protein [Rhodococcus equi
ATCC 33707]
gi|311889968|emb|CBH49286.1| putative transcriptional regulator [Rhodococcus equi 103S]
gi|325553714|gb|EGD23392.1| uroporphyrinogen-III synthase domain protein [Rhodococcus equi
ATCC 33707]
Length=389
Score = 368 bits (945), Expect = 8e-100, Method: Compositional matrix adjust.
Identities = 207/372 (56%), Positives = 259/372 (70%), Gaps = 1/372 (0%)
Query 9 LTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDIL 68
L G+ + +T++RRA+EL LL R+GA+V APAI++I L DD EL TE ++ADPPD++
Sbjct 12 LRGFTVGITASRRADELATLLVRRGADVVHAPAIRIIPLADDTELARVTETIVADPPDVI 71
Query 69 VAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESS 128
VA TGIGFRGW+ AAEGWG ELL +L S RI++RGPKATGA+RAAGLREEWSP+SESS
Sbjct 72 VATTGIGFRGWMGAAEGWGTGEELLTALGSTRILARGPKATGAVRAAGLREEWSPESESS 131
Query 129 HEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGG 188
EVLE+LL G++ RIAVQLHGA W+P P+F LR AGA V+ + VYRW P
Sbjct 132 AEVLEHLLGEGIAGRRIAVQLHGATTEWEPAPDFCAALRAAGAHVIAVPVYRWTPPDDCS 191
Query 189 VFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSR 248
D L+ + DAV+FTSAPA A++L R+++ + LL A V A CVGPVT+
Sbjct 192 AMDRLIESVGCGGLDAVSFTSAPAVASILGRAKQTGALEPLLRAFDGRVLAACVGPVTAA 251
Query 249 PLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLS 308
PL G PT+ P R RLG+LARHIA+ELP +A GH + +RG+ V+VD VK LS
Sbjct 252 PLTALGAPTTMPARSRLGSLARHIADELPRR-DAQVRAGGHELSVRGSCVVVDGEVKVLS 310
Query 309 PSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKR 368
P+GMA++R L RPG VVSR DLL LPG D HAV+TA+ RLR+ LG V TVVKR
Sbjct 311 PAGMALVRRLAERPGMVVSRADLLASLPGGSGDPHAVETAIARLRSHLGAPKAVQTVVKR 370
Query 369 GYRLAVDSRHDD 380
GYRLA+D D
Sbjct 371 GYRLALDPAEYD 382
>gi|297159962|gb|ADI09674.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Streptomyces bingchenggensis BCW-1]
Length=401
Score = 367 bits (943), Expect = 1e-99, Method: Compositional matrix adjust.
Identities = 205/379 (55%), Positives = 257/379 (68%), Gaps = 8/379 (2%)
Query 2 AQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALI 61
A A PL G+ + VT+ARRA+EL ALLRR+GA V APA++++ L DD EL T+ L+
Sbjct 24 APAAIGPLAGFTVGVTAARRADELAALLRRRGAAVMHAPALRIVPLADDAELLTATKQLL 83
Query 62 ADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEW 121
PD+++A T IGFRGW+ AA+GWGL + LL L AR+++RGPK GA+RAAGL EEW
Sbjct 84 DHAPDVVIATTAIGFRGWVEAADGWGLGDSLLARLRGARLLARGPKVRGAIRAAGLTEEW 143
Query 122 SPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRW 181
P SES EVL+ LLE GV +RIAVQLHG +P P F+ LR AGA+VV + VYRW
Sbjct 144 FPASESLAEVLDRLLEEGVDGSRIAVQLHG-----EPLPGFVESLRVAGAEVVGVPVYRW 198
Query 182 KPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMC 241
P G D L+ R DA+TFTSAPAAA++L+R+ + D+LL ALR DV C
Sbjct 199 MPPEDIGPVDRLLDATVARVLDALTFTSAPAAASLLDRAERRGMRDELLDALRHDVLPAC 258
Query 242 VGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSC-TFKAAGHVIEIRGTSVLV 300
VGPVT+ PL G+PTS PER RLG L + + ELP G AG +EIRG + LV
Sbjct 259 VGPVTALPLEAHGIPTSQPERFRLGPLVQLLTHELP--GRVRPLPVAGRRLEIRGHAALV 316
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D ++ + P+GMA+LRAL RPG VV+R DLLR LPG G D HAV+TA+ RLRTALG
Sbjct 317 DGELRAVPPAGMALLRALARRPGWVVARADLLRSLPGAGRDEHAVETAMARLRTALGAPK 376
Query 361 IVATVVKRGYRLAVDSRHD 379
++ TVVKRGYRLA+D D
Sbjct 377 LIQTVVKRGYRLALDPVAD 395
>gi|29831663|ref|NP_826297.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Streptomyces avermitilis MA-4680]
gi|29608779|dbj|BAC72832.1| putative transcriptional regulator [Streptomyces avermitilis
MA-4680]
Length=386
Score = 367 bits (943), Expect = 2e-99, Method: Compositional matrix adjust.
Identities = 199/378 (53%), Positives = 256/378 (68%), Gaps = 6/378 (1%)
Query 2 AQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALI 61
AQ PL G+ + VT+ARRA+EL ALL+R+GA V APA++++ L DD EL T+ LI
Sbjct 9 AQQDHGPLAGFTVGVTAARRADELGALLQRRGASVVHAPALRIVPLADDSELLAATKGLI 68
Query 62 ADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEW 121
PD++VA T IGFRGW+ AA+GWGL +L+E L +++RGPK GA+RAAGL EEW
Sbjct 69 EQAPDVVVATTAIGFRGWIEAADGWGLGEDLIERLRGVELLARGPKVKGAVRAAGLTEEW 128
Query 122 SPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRW 181
SP SES EVL+ LLE GV R+A+QLHG +P P F+ LR GA+VV + VYRW
Sbjct 129 SPSSESMAEVLDRLLEEGVDGRRVAIQLHG-----EPLPGFVEALRAGGAEVVGVPVYRW 183
Query 182 KPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMC 241
P D L+ R DA+TFTSAPAAA++L R+ E + +LAAL DV C
Sbjct 184 MPPEDITPVDRLLDATVTRGLDAITFTSAPAAASLLSRAEERGLLSDVLAALHHDVLPAC 243
Query 242 VGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVD 301
VGPVT+ PL +GV T PER RLG L + + +ELP T AGH +EIRG +V+VD
Sbjct 244 VGPVTALPLQARGVDTVQPERFRLGPLVQLLCKELPGRAR-TLPIAGHRVEIRGHAVMVD 302
Query 302 DSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNI 361
+++P+ P+GM++LRAL RPG VV+R +LLR LPG G D HAV+TA+ RLRTALG +
Sbjct 303 GALRPVPPAGMSLLRALARRPGWVVARAELLRALPGAGRDEHAVETAMARLRTALGAPKL 362
Query 362 VATVVKRGYRLAVDSRHD 379
+ TVVKRGYRLA+D D
Sbjct 363 IQTVVKRGYRLALDPAAD 380
>gi|297200053|ref|ZP_06917450.1| uroporphyrinogen-III synthase [Streptomyces sviceus ATCC 29083]
gi|197710526|gb|EDY54560.1| uroporphyrinogen-III synthase [Streptomyces sviceus ATCC 29083]
Length=384
Score = 365 bits (938), Expect = 5e-99, Method: Compositional matrix adjust.
Identities = 201/378 (54%), Positives = 255/378 (68%), Gaps = 6/378 (1%)
Query 2 AQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALI 61
A PL G+ + VT+ARRA+EL ALL+R+GA V APA++++ L DD EL T+ LI
Sbjct 7 AAEQHGPLAGFTVGVTAARRADELGALLQRRGAAVLHAPALRIVPLSDDSELLAATKDLI 66
Query 62 ADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEW 121
PD++VA T IGFRGW+ AAEGWGL LL+ L +++RGPK G++RAAGL E+W
Sbjct 67 DQAPDVVVATTAIGFRGWVEAAEGWGLGETLLDRLREVELLARGPKVKGSIRAAGLTEDW 126
Query 122 SPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRW 181
SP SES EVL+ LLE GV RIA+QLHG +P P F+ LR GA+VV + VYRW
Sbjct 127 SPSSESMAEVLDRLLEEGVEGRRIAIQLHG-----EPLPGFVEALRAGGAEVVGVPVYRW 181
Query 182 KPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMC 241
P G D L+ R DA+TFTSAPAAA++L R+ + + +LLAAL DV C
Sbjct 182 MPPEDIGPVDRLLDAAVSRGLDALTFTSAPAAASLLSRAEDRSLLPELLAALNHDVLPAC 241
Query 242 VGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVD 301
VGPVT+ PL +GV T APER RLG L + + +ELP AGH +EIRG +VLVD
Sbjct 242 VGPVTAVPLQARGVETVAPERFRLGPLVQLLCQELPGRARA-LPIAGHRVEIRGHAVLVD 300
Query 302 DSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNI 361
++P+ P+GM++LRAL RPG VVSR +LLR LPG G D HAV+TA+ RLRTALG +
Sbjct 301 GVLRPVPPAGMSLLRALSRRPGWVVSRAELLRALPGAGRDEHAVETAMARLRTALGAPKL 360
Query 362 VATVVKRGYRLAVDSRHD 379
+ TVVKRGYRLA+D D
Sbjct 361 IQTVVKRGYRLALDPAAD 378
>gi|329936531|ref|ZP_08286267.1| transcriptional regulator [Streptomyces griseoaurantiacus M045]
gi|329304046|gb|EGG47928.1| transcriptional regulator [Streptomyces griseoaurantiacus M045]
Length=393
Score = 364 bits (935), Expect = 1e-98, Method: Compositional matrix adjust.
Identities = 200/372 (54%), Positives = 253/372 (69%), Gaps = 6/372 (1%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + VT+ARRAEEL ALL R+GA V APA++++ L DD EL T+ L+ PD+
Sbjct 25 PLAGFTVGVTAARRAEELGALLERRGAVVQHAPALRIVPLSDDSELLAATKELLHQTPDV 84
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
+VA T IGFRGW+ AA+GWGL ELL L +++RGPK GA+RAAGL E WSP SES
Sbjct 85 VVATTAIGFRGWIEAADGWGLGEELLTRLRDVELLARGPKVKGAVRAAGLTERWSPSSES 144
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
EVL+ LLE GV RIAVQLHG +P P F+ LR +GA+VV + VYRW P
Sbjct 145 MAEVLDRLLEEGVEGRRIAVQLHG-----EPLPGFVEALRESGAEVVGVPVYRWMPPEDV 199
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
G D L+ DA+TFTSAPAAA++ R+RE + D LLA L +V A CVGPVT+
Sbjct 200 GPLDRLLDTTVAGGIDALTFTSAPAAASLFSRARERGMLDDLLAVLGHEVLAACVGPVTA 259
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL +GVPT PER RLG L + + ELP + T AGH +EIRG +VLVD ++P+
Sbjct 260 VPLQARGVPTVQPERFRLGPLVQLLCRELPAR-TRTLPVAGHRLEIRGHAVLVDGRLRPV 318
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+GM++LRAL HRPG VV R LLR LPG G D HAV+TA+ RLR AL +++ TVVK
Sbjct 319 PPAGMSLLRALAHRPGWVVPRAALLRALPGTGRDEHAVETAMTRLRAALATPHLIQTVVK 378
Query 368 RGYRLAVDSRHD 379
RGYRL++D+ +D
Sbjct 379 RGYRLSLDTPND 390
>gi|297561132|ref|YP_003680106.1| uroporphyrinogen III synthase HEM4 [Nocardiopsis dassonvillei
subsp. dassonvillei DSM 43111]
gi|296845580|gb|ADH67600.1| Uroporphyrinogen III synthase HEM4 [Nocardiopsis dassonvillei
subsp. dassonvillei DSM 43111]
Length=391
Score = 363 bits (931), Expect = 3e-98, Method: Compositional matrix adjust.
Identities = 200/372 (54%), Positives = 255/372 (69%), Gaps = 7/372 (1%)
Query 4 AHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIAD 63
A +APL G+ +AVT+ARRAEE+ ALLRR+GA+V +APA++++ L DD L + +E L
Sbjct 21 ATTAPLAGFTVAVTAARRAEEISALLRRKGAQVLAAPALRIVPLSDDQRLASVSEQLARR 80
Query 64 PPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSP 123
P D++VA TGIGFRGW+ A E WG + LL SL ++R+++RGPKA GA+RAAGL EEWSP
Sbjct 81 PADVVVATTGIGFRGWVEACETWGTVDPLLASLRTSRLLARGPKAKGAIRAAGLTEEWSP 140
Query 124 DSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKP 183
SESS EVL+YLL GV R+A+QLHG +P P+F LR AGA VV + VYRW
Sbjct 141 PSESSAEVLDYLLARGVRGLRVAIQLHG-----EPLPDFTAALRLAGADVVEVPVYRWTL 195
Query 184 APLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVG 243
D L+ + DAVTFTSAPAAA +L R+ + L+ ALR DV AMCVG
Sbjct 196 PEDTAPLDRLIEAVTNGGVDAVTFTSAPAAAGLLARAHTTGHQAALVRALRGDVLAMCVG 255
Query 244 PVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDS 303
VT+RPL+ +PT P+R R+GA R +AEELP T AGH + +RG +VLVD +
Sbjct 256 AVTARPLMAHDIPTVWPQRARVGAQVRALAEELPARFP-TLSVAGHRLRLRGHAVLVDGT 314
Query 304 VKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVA 363
V+ LSP+ M +LR L RPG V+ R LL L G+ +D HAV+TAV RLRTALGD I+
Sbjct 315 VRTLSPTLMRVLRELARRPGQVLDRTRLLTCL-GEDADAHAVETAVARLRTALGDPRIIQ 373
Query 364 TVVKRGYRLAVD 375
TVVKRGYRLA+D
Sbjct 374 TVVKRGYRLALD 385
>gi|291439327|ref|ZP_06578717.1| conserved hypothetical protein [Streptomyces ghanaensis ATCC
14672]
gi|291342222|gb|EFE69178.1| conserved hypothetical protein [Streptomyces ghanaensis ATCC
14672]
Length=383
Score = 362 bits (928), Expect = 8e-98, Method: Compositional matrix adjust.
Identities = 204/371 (55%), Positives = 248/371 (67%), Gaps = 6/371 (1%)
Query 9 LTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDIL 68
L G+ + VT+ARRA+EL ALL R+GA V APA++++ L DD EL TE +I PDI
Sbjct 13 LAGFTVGVTAARRADELGALLERRGAAVLHAPALRIVPLADDGELLAATEEIIERAPDIA 72
Query 69 VAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESS 128
VA T IGFRGW+ AA+GWGL LL L RI++RGPK GA+RAAGL EEWSP SES
Sbjct 73 VATTAIGFRGWVEAADGWGLGERLLARLGGVRILARGPKVKGAIRAAGLAEEWSPASESL 132
Query 129 HEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGG 188
EVL+ LL GV RIAVQLHG +P P F+ LR GA+VV + VYRW P G
Sbjct 133 AEVLDRLLAEGVDGLRIAVQLHG-----EPLPGFVESLRAGGAEVVGVPVYRWLPPEDLG 187
Query 189 VFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSR 248
D L+ R DAVTFTSAPAAA++L R+ E + D L+AAL DV CVGPVT+
Sbjct 188 PVDRLLDATVSRTLDAVTFTSAPAAASLLSRAGERGLLDDLVAALGHDVLPACVGPVTAL 247
Query 249 PLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLS 308
PL GV T PER RLG L + + ELP AGH +EIRG +VLVDD ++P+
Sbjct 248 PLQGHGVDTVQPERFRLGPLVQVLCRELPARARV-LPVAGHRVEIRGHAVLVDDELRPVP 306
Query 309 PSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKR 368
P+GM++LRAL RPG VV+R DLLR LPG G D HAV+TA+ RLR ALG ++ TVVKR
Sbjct 307 PAGMSLLRALARRPGWVVARADLLRALPGAGRDEHAVETAMARLRGALGAPGLIQTVVKR 366
Query 369 GYRLAVDSRHD 379
GYRLA+D R +
Sbjct 367 GYRLALDPRAE 377
>gi|320010503|gb|ADW05353.1| Uroporphyrinogen III synthase HEM4 [Streptomyces flavogriseus
ATCC 33331]
Length=385
Score = 361 bits (926), Expect = 1e-97, Method: Compositional matrix adjust.
Identities = 195/376 (52%), Positives = 252/376 (68%), Gaps = 6/376 (1%)
Query 4 AHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIAD 63
A PL G+ + VT+ARRAEEL LL R+GA V APA++++ L DD EL T+ L+ +
Sbjct 6 AQHGPLAGFTVGVTAARRAEELGTLLTRRGAAVLHAPALRIVPLADDSELLAATKDLVDN 65
Query 64 PPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSP 123
PPD+++A T IGFRGW+ AA+GWG+ +ELLE L +++RGPK GA+RAAGL E WSP
Sbjct 66 PPDVVIATTAIGFRGWVEAADGWGIGDELLELLRGIELLARGPKVKGAIRAAGLTEAWSP 125
Query 124 DSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKP 183
SES EVL+ LLE GV+ RIA+QLHG +P P F+ LR AGA++V + VYRW P
Sbjct 126 QSESMAEVLDRLLEEGVTGRRIALQLHG-----EPLPGFVESLRAAGAEIVGVPVYRWMP 180
Query 184 APLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVG 243
D ++ R DA+TFTSAPA A+ L R+ I ++L AL DV CVG
Sbjct 181 PEDIAPLDRMLDATVGRGLDALTFTSAPAVASYLNRAETRGILPEVLDALGHDVLTACVG 240
Query 244 PVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDS 303
PVT+ PL KG+ T PER RLG L + + +LP AGH +EIRG +VLVD +
Sbjct 241 PVTALPLQAKGIDTVQPERFRLGPLVQVLCAQLPARARA-LPVAGHRVEIRGHAVLVDGA 299
Query 304 VKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVA 363
++P+ P+GMA+L L RPG VVSR DLLR LPG+G+D HAV+TA+ RLRTALG ++
Sbjct 300 LRPVPPAGMALLHTLARRPGWVVSRADLLRALPGNGTDEHAVETAMARLRTALGAPRLIQ 359
Query 364 TVVKRGYRLAVDSRHD 379
TVVKRGYRLA+D D
Sbjct 360 TVVKRGYRLALDPSAD 375
>gi|345015563|ref|YP_004817917.1| Uroporphyrinogen III synthase HEM4 [Streptomyces violaceusniger
Tu 4113]
gi|344041912|gb|AEM87637.1| Uroporphyrinogen III synthase HEM4 [Streptomyces violaceusniger
Tu 4113]
Length=388
Score = 359 bits (922), Expect = 3e-97, Method: Compositional matrix adjust.
Identities = 198/374 (53%), Positives = 255/374 (69%), Gaps = 8/374 (2%)
Query 3 QAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIA 62
+A PL G+ + VT+ARRA+EL ALL+R+GA V APA++++ L DD EL T+ LI
Sbjct 12 EAPVGPLAGFTVGVTAARRADELGALLQRRGAAVMHAPALRIVPLADDSELMAATKQLID 71
Query 63 DPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWS 122
P +++A T IGFRGW+ AA+GWGL + LL+ L R+++RGPK GA+RAAGL EEW
Sbjct 72 HAPHVVIATTAIGFRGWVEAADGWGLGDALLDRLREVRLLARGPKVRGAIRAAGLTEEWY 131
Query 123 PDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWK 182
P SES EVL+ LLE GV RIA+QLHG +P P F+ LR GA+VV + VYRW
Sbjct 132 PPSESMAEVLDRLLEEGVEGQRIAIQLHG-----EPLPGFVESLRAGGAEVVGVPVYRWM 186
Query 183 PAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCV 242
P G D L+ R DAVTFTSAPAAA++L+R+ + ++LL ALR DV A CV
Sbjct 187 PPEDIGPVDRLLDATVARALDAVTFTSAPAAASLLDRAERRGMREELLDALRHDVLAACV 246
Query 243 GPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSC-TFKAAGHVIEIRGTSVLVD 301
GPVT+ PL +PTS PER RLG L + + ELP G AG +EIRG +V+VD
Sbjct 247 GPVTALPLEAHDIPTSQPERFRLGPLVQLLTTELP--GRVRPLPVAGRRLEIRGHAVVVD 304
Query 302 DSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNI 361
+++ + P+GMA+LRAL RPG VV+R +LLR LPG G D HAV+TA+ RLRTALG +
Sbjct 305 GALRTVPPAGMALLRALARRPGWVVARAELLRSLPGAGRDEHAVETAMARLRTALGSPKL 364
Query 362 VATVVKRGYRLAVD 375
+ TVVKRGYRLA+D
Sbjct 365 IQTVVKRGYRLALD 378
>gi|290959973|ref|YP_003491155.1| transcriptional regulator [Streptomyces scabiei 87.22]
gi|260649499|emb|CBG72614.1| putative transcriptional regulator [Streptomyces scabiei 87.22]
Length=384
Score = 357 bits (917), Expect = 2e-96, Method: Compositional matrix adjust.
Identities = 198/378 (53%), Positives = 252/378 (67%), Gaps = 6/378 (1%)
Query 2 AQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALI 61
A PL G+ + VT+ARRA+EL ALL+R+GA V APA++++ L DD EL T+ L+
Sbjct 8 APTDHGPLAGFTVGVTAARRADELGALLQRRGAAVLHAPALRIVPLADDSELLAATKDLL 67
Query 62 ADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEW 121
PDI+VA T IGFRGW+ AA+GWGL LL+ L +++RGPK GA+RAAGL EEW
Sbjct 68 DQAPDIVVATTAIGFRGWIEAADGWGLGEALLDRLRGVELLARGPKVKGAIRAAGLTEEW 127
Query 122 SPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRW 181
SP SES EVL+ LLE GV R+A+QLHG +P P F+ LR AGA+VV + VYRW
Sbjct 128 SPSSESMAEVLDRLLEQGVEGRRLAIQLHG-----EPLPGFVESLRAAGAEVVGVPVYRW 182
Query 182 KPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMC 241
P D L+ R DA+TFTSAPAAA++L R+ + + +LL AL DV C
Sbjct 183 MPPEDITPMDRLLDAAIGRGLDALTFTSAPAAASLLSRAEDRGLLPELLNALGHDVLPAC 242
Query 242 VGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVD 301
VGPVT+ PL GV T PER RLG L + + +ELP T AGH +EIRG +VLVD
Sbjct 243 VGPVTALPLQAHGVDTVQPERFRLGPLVQLLCQELPGRAR-TLPIAGHRVEIRGHAVLVD 301
Query 302 DSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNI 361
++P+ P+GM++LRAL RPG VV R DLL+ LPG G D HAV+TA+ RLRT+LG +
Sbjct 302 GDLRPVPPAGMSLLRALCRRPGWVVPRSDLLKALPGAGRDEHAVETAMARLRTSLGTPKL 361
Query 362 VATVVKRGYRLAVDSRHD 379
+ TVVKRGYRLA+D D
Sbjct 362 IQTVVKRGYRLALDPTAD 379
>gi|343927594|ref|ZP_08767062.1| hypothetical protein GOALK_097_00140 [Gordonia alkanivorans NBRC
16433]
gi|343762235|dbj|GAA13988.1| hypothetical protein GOALK_097_00140 [Gordonia alkanivorans NBRC
16433]
Length=396
Score = 355 bits (912), Expect = 5e-96, Method: Compositional matrix adjust.
Identities = 212/370 (58%), Positives = 261/370 (71%), Gaps = 1/370 (0%)
Query 10 TGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDILV 69
TG+ I +T+ARRAEE ALL R+GA V AP I+++ L DD EL+ TE +IA PP I+V
Sbjct 24 TGFTIGITAARRAEEFAALLERRGARVVQAPTIRILPLVDDTELERVTEEIIASPPQIMV 83
Query 70 AHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESSH 129
A TGIGFRGW+ AA+GWG A ++L SLS +R+I+RGPKA GA+RAAGLREEWSP+SESS
Sbjct 84 ATTGIGFRGWIEAADGWGNAEDVLRSLSQSRLIARGPKAKGAIRAAGLREEWSPESESSS 143
Query 130 EVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGV 189
EVL++LL GV RIAVQLHGA W+P P+F LR AGA VVPI VYRW P
Sbjct 144 EVLDHLLAEGVEGVRIAVQLHGATSEWEPLPDFCTVLRAAGAVVVPIPVYRWNMHPDVAR 203
Query 190 FDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSRP 249
D ++ + R DA+TFTSAPAAA++L R++EL Q + ALRT V MCVG VT+ P
Sbjct 204 IDKMIAQVLRGDLDAITFTSAPAAASILTRAKELGKLQQFVHALRTAVPVMCVGSVTASP 263
Query 250 LIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPLSP 309
L +PT+ P R RLGALAR I +ELP + AGH IRG +V+VD +K LS
Sbjct 264 LEALQIPTTYPRRFRLGALARLITDELPRRAHV-LRVAGHDTAIRGQAVVVDGELKDLSA 322
Query 310 SGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVKRG 369
+G+ +L+ L PG VVSR ++L VLPGD SDTHAV+ AV RLR ALGD +V TVVKRG
Sbjct 323 TGLLLLKLLARNPGRVVSRQEMLAVLPGDSSDTHAVEVAVARLRAALGDSKMVQTVVKRG 382
Query 370 YRLAVDSRHD 379
YRLAVD +D
Sbjct 383 YRLAVDLEYD 392
>gi|345000010|ref|YP_004802864.1| Uroporphyrinogen III synthase HEM4 [Streptomyces sp. SirexAA-E]
gi|344315636|gb|AEN10324.1| Uroporphyrinogen III synthase HEM4 [Streptomyces sp. SirexAA-E]
Length=381
Score = 355 bits (910), Expect = 9e-96, Method: Compositional matrix adjust.
Identities = 195/376 (52%), Positives = 248/376 (66%), Gaps = 6/376 (1%)
Query 4 AHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIAD 63
A PL G+ + VT+ARRAEEL LL R+GA V APA++++ L DD EL TE L+ D
Sbjct 6 AQHGPLAGFTVGVTAARRAEELGTLLTRRGAAVLHAPALRIVPLADDSELLAATEELLDD 65
Query 64 PPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSP 123
PD+++A T IGFRGW+ AA+GWG+ + LLE L +++RGPK GA+RAAGL E WSP
Sbjct 66 VPDVVIATTAIGFRGWVEAADGWGIGDRLLEVLRGGELLARGPKVKGAIRAAGLTEAWSP 125
Query 124 DSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKP 183
SES EVL+ LL GV RIA+QLHG +P P F+ LR AGA+VV + VYRW P
Sbjct 126 GSESMAEVLDRLLGEGVEGRRIALQLHG-----EPLPGFVDALREAGAEVVGVPVYRWMP 180
Query 184 APLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVG 243
D ++ R DA+TFTSAPAAA+ L R+ + Q+L+AL DV CVG
Sbjct 181 PQDIAPLDRMLDVTVARGLDALTFTSAPAAASYLNRAESRGMLPQVLSALGHDVVVACVG 240
Query 244 PVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDS 303
PVT+ PL +G+ T PER RLG L + + LP AGH++EIRG +VLVD +
Sbjct 241 PVTALPLQARGIDTVQPERFRLGPLVQLLCAHLPARARA-LPVAGHLVEIRGHAVLVDRA 299
Query 304 VKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVA 363
+ P+ P+GMA+L AL RPG VVSR DLLR LPG G+D HAV+TA+ RLRT LG ++
Sbjct 300 LHPVPPAGMALLHALARRPGWVVSRADLLRALPGSGTDEHAVETAMARLRTVLGAPELIQ 359
Query 364 TVVKRGYRLAVDSRHD 379
TVVKRGYRLA+D D
Sbjct 360 TVVKRGYRLALDPAAD 375
>gi|239988104|ref|ZP_04708768.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Streptomyces roseosporus NRRL 11379]
gi|291445083|ref|ZP_06584473.1| conserved hypothetical protein [Streptomyces roseosporus NRRL
15998]
gi|291348030|gb|EFE74934.1| conserved hypothetical protein [Streptomyces roseosporus NRRL
15998]
Length=380
Score = 354 bits (908), Expect = 1e-95, Method: Compositional matrix adjust.
Identities = 193/372 (52%), Positives = 249/372 (67%), Gaps = 6/372 (1%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + VT+ARRAEEL LL+R+GA V APA++++ L DD EL T+ LI PD+
Sbjct 10 PLAGFTVGVTAARRAEELGTLLKRRGAAVLHAPALRIVQLADDSELLAATKELIGHAPDV 69
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
VA T IGFRGW+ AA+GWG+ + LL++L +++RGPK GA+RAAGL E WSP SES
Sbjct 70 AVATTAIGFRGWIEAADGWGIGDALLQTLRGVELLARGPKVKGAIRAAGLTETWSPGSES 129
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
EVL+ LL GV+ R+A+QLHG +P P F+ L AGA+VV + VYRW P
Sbjct 130 MAEVLDRLLAEGVAGRRVALQLHG-----EPLPGFVESLTAAGAEVVVVPVYRWMPPQDI 184
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
D ++ A R DA+TFTSAPAAA+ L R+ + ++L ALR DV CVGPVT+
Sbjct 185 APLDRMLDVTAARGLDAITFTSAPAAASFLGRAETRGLLPEILGALRDDVLVACVGPVTA 244
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL +G+ T PER RLG L + + LP + AGH IEIRG +VLVDD ++ +
Sbjct 245 LPLQARGIDTLQPERFRLGPLVQLMCAHLP-AAARILPVAGHRIEIRGHAVLVDDELRAV 303
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+GMA+L AL RPG VV+R DLLR LPG GSD HAV+TA+ RLR+ALG ++ TVVK
Sbjct 304 PPAGMALLHALARRPGWVVARADLLRALPGSGSDEHAVETAMARLRSALGVPRLIQTVVK 363
Query 368 RGYRLAVDSRHD 379
RGYRLA+D D
Sbjct 364 RGYRLALDPSAD 375
>gi|326779020|ref|ZP_08238285.1| Uroporphyrinogen III synthase HEM4 [Streptomyces cf. griseus
XylebKG-1]
gi|326659353|gb|EGE44199.1| Uroporphyrinogen III synthase HEM4 [Streptomyces griseus XylebKG-1]
Length=380
Score = 353 bits (906), Expect = 2e-95, Method: Compositional matrix adjust.
Identities = 194/372 (53%), Positives = 248/372 (67%), Gaps = 6/372 (1%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + VT+ARRAEEL LL R+GA V APA++++ L DD EL T LI PD+
Sbjct 10 PLAGFTVGVTAARRAEELATLLERRGAAVLHAPALRIVQLADDSELLAATRELIGHAPDV 69
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
VA T IGFRGW+ AA+GWG+ + LL++L +++RGPK GA+RAAGL E WSP SES
Sbjct 70 AVATTAIGFRGWIEAADGWGVGDALLKTLGGVELLARGPKVKGAVRAAGLTETWSPGSES 129
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
EVL+ LL GV+ RIA+QLHG +P P F+ L AGA VV + VYRW P
Sbjct 130 MAEVLDRLLAQGVAGRRIALQLHG-----EPLPGFVESLTAAGADVVVVPVYRWMPPRDI 184
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
D ++ A R DA+TFTSAPAAA+ L R+ + ++L ALR DV CVGPVT+
Sbjct 185 APLDRMLDVTAARGLDAITFTSAPAAASFLGRAETRGLLPEILGALRDDVLVACVGPVTA 244
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL +G+ T PER RLG L + + LP L + AGH +EIRG +VLVDD ++ +
Sbjct 245 LPLQARGIDTLQPERFRLGPLVQLMCARLP-LAARILPVAGHRVEIRGHAVLVDDELRAV 303
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+GMA+L AL RPG VV+R DLLRVLPG G+D HAV+TA+ RLR+ALG ++ TVVK
Sbjct 304 PPAGMALLHALARRPGWVVARADLLRVLPGSGTDEHAVETAMARLRSALGVPRLIQTVVK 363
Query 368 RGYRLAVDSRHD 379
RGYRLA+D D
Sbjct 364 RGYRLALDPSAD 375
>gi|182438369|ref|YP_001826088.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain protein [Streptomyces griseus subsp. griseus NBRC
13350]
gi|178466885|dbj|BAG21405.1| putative transcriptional regulator [Streptomyces griseus subsp.
griseus NBRC 13350]
Length=380
Score = 353 bits (906), Expect = 3e-95, Method: Compositional matrix adjust.
Identities = 194/372 (53%), Positives = 248/372 (67%), Gaps = 6/372 (1%)
Query 8 PLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDI 67
PL G+ + VT+ARRAEEL LL R+GA V APA++++ L DD EL T LI PD+
Sbjct 10 PLAGFTVGVTAARRAEELATLLERRGAAVLHAPALRIVQLADDSELLAATRELIGHAPDV 69
Query 68 LVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSES 127
VA T IGFRGW+ AA+GWG+ + LL++L +++RGPK GA+RAAGL E WSP SES
Sbjct 70 AVATTAIGFRGWIEAADGWGVGDALLKTLGGVELLARGPKVKGAVRAAGLTETWSPGSES 129
Query 128 SHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLG 187
EVL+ LL GV+ RIA+QLHG +P P F+ L AGA VV + VYRW P
Sbjct 130 MAEVLDRLLAQGVAGRRIALQLHG-----EPLPGFVESLTAAGADVVVVPVYRWMPPRDI 184
Query 188 GVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTS 247
D ++ A R DA+TFTSAPAAA+ L R+ + ++L ALR DV CVGPVT+
Sbjct 185 APLDRMLDVTAARGLDAITFTSAPAAASFLGRAETRGLLPEILGALRDDVLVACVGPVTA 244
Query 248 RPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDDSVKPL 307
PL +G+ T PER RLG L + + LP L + AGH +EIRG +VLVDD ++ +
Sbjct 245 LPLQARGIDTLQPERFRLGPLIQLMCARLP-LAARILPVAGHRVEIRGHAVLVDDELRAV 303
Query 308 SPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIVATVVK 367
P+GMA+L AL RPG VV+R DLLRVLPG G+D HAV+TA+ RLR+ALG ++ TVVK
Sbjct 304 PPAGMALLHALARRPGWVVARADLLRVLPGSGTDEHAVETAMARLRSALGVPRLIQTVVK 363
Query 368 RGYRLAVDSRHD 379
RGYRLA+D D
Sbjct 364 RGYRLALDPSAD 375
>gi|289771313|ref|ZP_06530691.1| conserved hypothetical protein [Streptomyces lividans TK24]
gi|289701512|gb|EFD68941.1| conserved hypothetical protein [Streptomyces lividans TK24]
Length=383
Score = 353 bits (906), Expect = 3e-95, Method: Compositional matrix adjust.
Identities = 197/377 (53%), Positives = 250/377 (67%), Gaps = 6/377 (1%)
Query 3 QAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIA 62
Q PL G+ + VT+ARRA+EL ALL R+GA V APA++++ L DD EL T+ ++
Sbjct 7 QPGHGPLAGFTVGVTAARRADELGALLGRRGATVLHAPALRIVPLADDGELMAATKRIVD 66
Query 63 DPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWS 122
PD++VA T IGFRGW+ AA+GWGL + LLE L + +++RGPK GA+RAAGL E WS
Sbjct 67 RAPDVVVATTAIGFRGWVEAADGWGLGDALLERLRTVELLARGPKVKGAVRAAGLTERWS 126
Query 123 PDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWK 182
P SES EVL+ LLE GV+ RIAVQLHG +P P F+ LR GA+VV + VYRW
Sbjct 127 PASESMAEVLDRLLEQGVAGRRIAVQLHG-----EPLPGFVEALREGGAEVVGVPVYRWL 181
Query 183 PAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCV 242
P G D L+ R DAVTFTSAPAA ++L R+ E + +LLAA DV CV
Sbjct 182 PPEDLGPVDRLLDAAVSRGVDAVTFTSAPAAVSLLGRAEERGLLPELLAAFGHDVLPACV 241
Query 243 GPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDD 302
GPVT+ PL GV T PER RLG L + + +ELP AGH +EIRG +VLVD
Sbjct 242 GPVTAVPLQAHGVDTVQPERFRLGPLVQLLCQELPARARA-LPVAGHRLEIRGHAVLVDG 300
Query 303 SVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIV 362
++ + P+GM++LRAL RPG VV R +LLR LPG G D HAV+TA+ RLRT+LG ++
Sbjct 301 ELRTVPPAGMSLLRALARRPGWVVPRAELLRALPGTGRDEHAVETAMARLRTSLGTPKLI 360
Query 363 ATVVKRGYRLAVDSRHD 379
TVVKRGYRLA+D D
Sbjct 361 QTVVKRGYRLALDPATD 377
>gi|328882767|emb|CCA56006.1| putative transcriptional regulator [Streptomyces venezuelae ATCC
10712]
Length=408
Score = 353 bits (906), Expect = 3e-95, Method: Compositional matrix adjust.
Identities = 200/379 (53%), Positives = 255/379 (68%), Gaps = 8/379 (2%)
Query 3 QAH--SAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEAL 60
Q H + PL G+ + VT+ARRA+EL ALLRR+GA V PA++++ L DD EL T+ L
Sbjct 31 QEHGPAGPLAGFTVGVTAARRADELIALLRRRGAAVVHGPALRIVPLADDTELLAATKEL 90
Query 61 IADPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREE 120
IA PD++VA T IGFRGW+ AAEGWG +LL L +++RGPK GA+RAAGL E
Sbjct 91 IAHAPDVVVATTAIGFRGWVEAAEGWGYGEDLLAVLRDVELLARGPKVKGAVRAAGLTES 150
Query 121 WSPDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYR 180
WSP SES EVL+ LL GV RIA+QLHG +P P F+ L GA+VV + VYR
Sbjct 151 WSPGSESMAEVLDRLLAEGVDGRRIALQLHG-----EPLPGFVEALTAGGAEVVGVPVYR 205
Query 181 WKPAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAM 240
W P G D L+ I DAVTFTSAPAAA++ R+ E + D+L+AALR DV ++
Sbjct 206 WMPPEDTGPLDRLLDAILSGGLDAVTFTSAPAAASLFARAAEKGVRDRLVAALRHDVLSV 265
Query 241 CVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLV 300
CVGPVT+ PL +G+ T APER RLG L + + ELP S AGH +E+RG +VLV
Sbjct 266 CVGPVTALPLQAEGIDTRAPERFRLGPLVQLLCTELPAR-SRVLPVAGHRVEVRGHAVLV 324
Query 301 DDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKN 360
D ++P+ P+GMA+L L RPG VVSR DLLR LPG G D HAV+TA+ RLR+ALG
Sbjct 325 DGVLRPVPPAGMALLGLLARRPGWVVSRADLLRALPGAGRDEHAVETAMARLRSALGTPK 384
Query 361 IVATVVKRGYRLAVDSRHD 379
++ TVVKRGYRL++D+ D
Sbjct 385 LIQTVVKRGYRLSLDATPD 403
>gi|21221403|ref|NP_627182.1| bifunctional uroporphyrinogen-III synthetase/response regulator
domain-containing protein [Streptomyces coelicolor A3(2)]
gi|6911988|emb|CAB72204.1| putative transcriptional regulator [Streptomyces coelicolor A3(2)]
Length=395
Score = 353 bits (905), Expect = 4e-95, Method: Compositional matrix adjust.
Identities = 197/377 (53%), Positives = 250/377 (67%), Gaps = 6/377 (1%)
Query 3 QAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIA 62
Q PL G+ + VT+ARRA+EL ALL R+GA V APA++++ L DD EL T+ ++
Sbjct 19 QPGHGPLAGFTVGVTAARRADELGALLGRRGATVLHAPALRIVPLADDGELMAATKRIVD 78
Query 63 DPPDILVAHTGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWS 122
PD++VA T IGFRGW+ AA+GWGL + LLE L + +++RGPK GA+RAAGL E WS
Sbjct 79 RAPDVVVATTAIGFRGWVEAADGWGLGDALLERLRTVELLARGPKVKGAVRAAGLTERWS 138
Query 123 PDSESSHEVLEYLLESGVSRTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWK 182
P SES EVL+ LLE GV+ RIAVQLHG +P P F+ LR GA+VV + VYRW
Sbjct 139 PASESMAEVLDRLLEQGVAGRRIAVQLHG-----EPLPGFVEALREGGAEVVGVPVYRWL 193
Query 183 PAPLGGVFDHLVTGIARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCV 242
P G D L+ R DAVTFTSAPAA ++L R+ E + +LLAA DV CV
Sbjct 194 PPEDLGPVDRLLDAAVSRGVDAVTFTSAPAAVSLLGRAEERGLLPELLAAFGHDVLPACV 253
Query 243 GPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGTSVLVDD 302
GPVT+ PL GV T PER RLG L + + +ELP AGH +EIRG +VLVD
Sbjct 254 GPVTAVPLQAHGVDTVQPERFRLGPLVQLLCQELPARARA-LPVAGHRLEIRGHAVLVDG 312
Query 303 SVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLRLRTALGDKNIV 362
++ + P+GM++LRAL RPG VV R +LLR LPG G D HAV+TA+ RLRT+LG ++
Sbjct 313 ELRTVPPAGMSLLRALARRPGWVVPRAELLRALPGTGRDEHAVETAMARLRTSLGTPKLI 372
Query 363 ATVVKRGYRLAVDSRHD 379
TVVKRGYRLA+D D
Sbjct 373 QTVVKRGYRLALDPATD 389
Lambda K H
0.320 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 737398932000
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
Posted date: Sep 5, 2011 4:36 AM
Number of letters in database: 5,219,829,388
Number of sequences in database: 15,229,318
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40