BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0405 Length=1402 Score E Sequences producing significant alignments: (Bits) Value gi|15607546|ref|NP_214919.1| membrane bound polyketide synthase ... 2829 0.0 gi|148821601|ref|YP_001286355.1| membrane bound polyketide synth... 2827 0.0 gi|344218221|gb|AEM98851.1| membrane bound polyketide synthase [... 2826 0.0 gi|289568319|ref|ZP_06448546.1| membrane bound polyketide syntha... 2826 0.0 gi|15839791|ref|NP_334828.1| polyketide synthase [Mycobacterium ... 2826 0.0 gi|254363369|ref|ZP_04979415.1| membrane bound polyketide syntha... 2825 0.0 gi|289445944|ref|ZP_06435688.1| membrane bound polyketide syntha... 2824 0.0 gi|289572990|ref|ZP_06453217.1| membrane bound polyketide syntha... 2824 0.0 gi|289744101|ref|ZP_06503479.1| membrane bound polyketide syntha... 2767 0.0 gi|289441784|ref|ZP_06431528.1| membrane bound polyketide syntha... 2618 0.0 gi|340625431|ref|YP_004743883.1| polyketide synthase pks6 [Mycob... 2151 0.0 gi|339293459|gb|AEJ45570.1| membrane bound polyketide synthase p... 2118 0.0 gi|308371664|ref|ZP_07667220.1| putative acyl transferase domain... 2048 0.0 gi|308370397|ref|ZP_07421359.2| membrane bound polyketide syntha... 1955 0.0 gi|167970780|ref|ZP_02553057.1| membrane bound polyketide syntha... 1935 0.0 gi|254549350|ref|ZP_05139797.1| membrane bound polyketide syntha... 1933 0.0 gi|121636319|ref|YP_976542.1| putative membrane bound polyketide... 1885 0.0 gi|31791583|ref|NP_854076.1| polyketide synthase [Mycobacterium ... 1883 0.0 gi|289760521|ref|ZP_06519899.1| membrane bound polyketide syntha... 1712 0.0 gi|289756474|ref|ZP_06515852.1| predicted protein [Mycobacterium... 1617 0.0 gi|183980730|ref|YP_001849021.1| polyketide synthase Pks6 [Mycob... 1430 0.0 gi|289756473|ref|ZP_06515851.1| polyketide synthase [Mycobacteri... 999 0.0 gi|31791582|ref|NP_854075.1| polyketide synthase [Mycobacterium ... 939 0.0 gi|339298599|gb|AEJ50709.1| polyketide synthase Pks12 [Mycobacte... 892 0.0 gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085... 891 0.0 gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobact... 891 0.0 gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_1090... 891 0.0 gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933... 891 0.0 gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 ... 891 0.0 gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycob... 891 0.0 gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycob... 891 0.0 gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12... 891 0.0 gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacteri... 890 0.0 gi|340627059|ref|YP_004745511.1| putative polyketide synthase pk... 890 0.0 gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_1100... 890 0.0 gi|289750639|ref|ZP_06510017.1| polyketide synthase pks8 [Mycoba... 890 0.0 gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobact... 890 0.0 gi|289554169|ref|ZP_06443379.1| polyketide synthase Pks12 [Mycob... 890 0.0 gi|118463709|ref|YP_881643.1| erythronolide synthase, modules 3 ... 889 0.0 gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Myco... 889 0.0 gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium ... 886 0.0 gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Myc... 882 0.0 gi|41407894|ref|NP_960730.1| Pks12 [Mycobacterium avium subsp. p... 881 0.0 gi|254822171|ref|ZP_05227172.1| erythronolide synthase, modules ... 878 0.0 gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycoba... 877 0.0 gi|342859764|ref|ZP_08716417.1| erythronolide synthase, modules ... 874 0.0 gi|296165135|ref|ZP_06847686.1| possible erythronolide synthase,... 872 0.0 gi|15826966|ref|NP_301229.1| polyketide synthase [Mycobacterium ... 866 0.0 gi|336457823|gb|EGO36817.1| polyketide synthase family protein [... 861 0.0 gi|302540056|ref|ZP_07292398.1| modular polyketide synthase [Str... 860 0.0 >gi|15607546|ref|NP_214919.1| membrane bound polyketide synthase [Mycobacterium tuberculosis H37Rv] gi|148660170|ref|YP_001281693.1| membrane bound polyketide synthase Pks6 [Mycobacterium tuberculosis H37Ra] gi|306774499|ref|ZP_07412836.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis SUMu001] 9 more sequence titles Length=1402 Score = 2829 bits (7334), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1402/1402 (100%), Positives = 1402/1402 (100%), Gaps = 0/1402 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPHR 1402 SSEAIATEIHDWISGLVRGPHR Sbjct 1381 SSEAIATEIHDWISGLVRGPHR 1402 >gi|148821601|ref|YP_001286355.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis F11] gi|253797328|ref|YP_003030329.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis KZN 1435] gi|289552654|ref|ZP_06441864.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis KZN 605] 9 more sequence titles Length=1402 Score = 2827 bits (7329), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1401/1401 (100%), Positives = 1401/1401 (100%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|344218221|gb|AEM98851.1| membrane bound polyketide synthase [Mycobacterium tuberculosis CTRI-2] Length=1402 Score = 2826 bits (7325), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1400/1401 (99%), Positives = 1401/1401 (100%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARED+VAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDDVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|289568319|ref|ZP_06448546.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T17] gi|289752434|ref|ZP_06511812.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis EAS054] gi|289542072|gb|EFD45721.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T17] gi|289693021|gb|EFD60450.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis EAS054] Length=1402 Score = 2826 bits (7325), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1400/1401 (99%), Positives = 1401/1401 (100%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREY+STHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYVSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|15839791|ref|NP_334828.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|13879921|gb|AAK44642.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|323721076|gb|EGB30138.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CDC1551A] Length=1402 Score = 2826 bits (7325), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1400/1401 (99%), Positives = 1401/1401 (100%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTD+FLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDVFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|254363369|ref|ZP_04979415.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis str. Haarlem] gi|134148883|gb|EBA40928.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis str. Haarlem] Length=1402 Score = 2825 bits (7322), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1399/1401 (99%), Positives = 1401/1401 (100%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL+MSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLVMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTD+FLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDVFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|289445944|ref|ZP_06435688.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CPHL_A] gi|289418902|gb|EFD16103.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CPHL_A] Length=1402 Score = 2824 bits (7321), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1400/1401 (99%), Positives = 1400/1401 (99%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVV VGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVGVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|289572990|ref|ZP_06453217.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis K85] gi|339630474|ref|YP_004722116.1| polyketide synthase [Mycobacterium africanum GM041182] gi|289537421|gb|EFD41999.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis K85] gi|339329830|emb|CCC25479.1| putative membrane bound polyketide synthase PKS6 [Mycobacterium africanum GM041182] Length=1402 Score = 2824 bits (7320), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1400/1401 (99%), Positives = 1400/1401 (99%), Gaps = 0/1401 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 L VALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI Sbjct 1261 LRVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAI 1320 Query 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST Sbjct 1321 FQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMST 1380 Query 1381 SSEAIATEIHDWISGLVRGPH 1401 SSEAIATEIHDWISGLVRGPH Sbjct 1381 SSEAIATEIHDWISGLVRGPH 1401 >gi|289744101|ref|ZP_06503479.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis 02_1987] gi|298523881|ref|ZP_07011290.1| membrane bound polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|289684629|gb|EFD52117.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis 02_1987] gi|298493675|gb|EFI28969.1| membrane bound polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=1389 Score = 2767 bits (7172), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1374/1374 (100%), Positives = 1374/1374 (100%), Gaps = 0/1374 (0%) Query 28 NEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS 87 NEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS Sbjct 15 NEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS 74 Query 88 LRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGF 147 LRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGF Sbjct 75 LRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGF 134 Query 148 TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLR 207 TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLR Sbjct 135 TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLR 194 Query 208 LSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTA 267 LSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTA Sbjct 195 LSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTA 254 Query 268 CSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSAD 327 CSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSAD Sbjct 255 CSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSAD 314 Query 328 GMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENAC 387 GMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENAC Sbjct 315 GMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENAC 374 Query 388 KSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGA 447 KSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGA Sbjct 375 KSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGA 434 Query 448 AGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVS 507 AGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVS Sbjct 435 AGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVS 494 Query 508 SFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRY 567 SFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRY Sbjct 495 SFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRY 554 Query 568 VRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKP 627 VRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKP Sbjct 555 VRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKP 614 Query 628 AGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLL 687 AGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLL Sbjct 615 AGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLL 674 Query 688 NTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAAR 747 NTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAAR Sbjct 675 NTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAAR 734 Query 748 GRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRG 807 GRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRG Sbjct 735 GRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRG 794 Query 808 QGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADY 867 QGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADY Sbjct 795 QGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADY 854 Query 868 WARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPE 927 WARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPE Sbjct 855 WARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPE 914 Query 928 PVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQ 987 PVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQ Sbjct 915 PVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQ 974 Query 988 IGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFAD 1047 IGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFAD Sbjct 975 IGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFAD 1034 Query 1048 SGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE 1107 SGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE Sbjct 1035 SGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE 1094 Query 1108 RIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVI 1167 RIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVI Sbjct 1095 RIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVI 1154 Query 1168 CIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVV 1227 CIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVV Sbjct 1155 CIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVV 1214 Query 1228 GGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPND 1287 GGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPND Sbjct 1215 GGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPND 1274 Query 1288 TGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVEN 1347 TGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVEN Sbjct 1275 TGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVEN 1334 Query 1348 LREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 1401 LREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH Sbjct 1335 LREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 1388 >gi|289441784|ref|ZP_06431528.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T46] gi|289414703|gb|EFD11943.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T46] Length=1302 Score = 2618 bits (6785), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1298/1299 (99%), Positives = 1299/1299 (100%), Gaps = 0/1299 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREY+STHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYVSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT Sbjct 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE Sbjct 1081 PTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRE 1140 Query 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP Sbjct 1141 RMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLP 1200 Query 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP Sbjct 1201 GFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNP 1260 Query 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRV 1299 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRV Sbjct 1261 LGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRV 1299 >gi|340625431|ref|YP_004743883.1| polyketide synthase pks6 [Mycobacterium canettii CIPT 140010059] gi|340003621|emb|CCC42743.1| polyketide synthase pks6 [Mycobacterium canettii CIPT 140010059] Length=2410 Score = 2151 bits (5574), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1070/1107 (97%), Positives = 1081/1107 (98%), Gaps = 2/1107 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPF 480 Query 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGS 540 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEA V +D V AD GS Sbjct 481 TELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAFPVESDGVCAGAD--GS 538 Query 541 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 600 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT Sbjct 539 GGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQT 598 Query 601 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 660 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL Sbjct 599 RDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEAL 658 Query 661 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 720 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG Sbjct 659 DAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLG 718 Query 721 HSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 780 HSVGELAAAH+AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI Sbjct 719 HSVGELAAAHIAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSI 778 Query 781 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 840 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL Sbjct 779 AAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAEL 838 Query 841 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 900 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG Sbjct 839 SVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGG 898 Query 901 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 960 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE Sbjct 899 GLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVE 958 Query 961 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1020 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI Sbjct 959 LPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAI 1018 Query 1021 EVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPT 1080 EVVCEHAAAVLGR AA +DA QAF DSG NSLSAVELRNRL AVT TL ATA+FD+PT Sbjct 1019 EVVCEHAAAVLGRGDAASVDAAQAFTDSGLNSLSAVELRNRLKAVTGATLSATAVFDYPT 1078 Query 1081 PTELAQYLITQIDGHGSSAAAAANPAE 1107 PT+LA+YL++ +DG G SAAA + A Sbjct 1079 PTDLARYLVSHLDGAGRSAAAVVSRAR 1105 Score = 2042 bits (5291), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1095/1384 (80%), Positives = 1174/1384 (85%), Gaps = 39/1384 (2%) Query 38 DLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQ-----RSADSLRESH 92 D GL S+ + + L G + AV+D P+ DL L++ RSA ++ Sbjct 1045 DSGLNSLSAVELRNRLKAVTGATLSATAVFDYPTPTDLARYLVSHLDGAGRSAAAVV--- 1101 Query 93 GHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DRGFTNAG 151 ++ R EP+AV+G+GCR+PG + E LW + + I+ +P DRG+ G Sbjct 1102 ------SRARVRTGEPIAVVGMGCRYPGGVVTAEDLWQLVASGRDVISEFPADRGWDVEG 1155 Query 152 -----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAG 200 + GGF+ DVA FD FF I P EAL MDPQQRLLLE+SWEALE+AG Sbjct 1156 LYDADPDVLGKCYTRQGGFVDDVANFDAGFFGISPGEALAMDPQQRLLLEISWEALENAG 1215 Query 201 IIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGP 260 I P +LR S TGVFVG+ Y ++ + +TG +S+ + RI+Y L + GP Sbjct 1216 IDPLALRGSATGVFVGIYGDGY-----GVGTSQAQWYADTGHITSVASGRIAYSLGLTGP 1270 Query 261 SIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCH 320 ++ +DTACSSSLVA+HLA SL +CD+AL GG+ VL++P + GF LS G C Sbjct 1271 ALSVDTACSSSLVALHLAANSLRAGECDLALAGGSTVLVTPSIFLGFSRQRGLSVDGRCK 1330 Query 321 AFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQI 380 AF +ADG EG GV+V+QRL DAR GRR+LA+L GSAVNQDG SNG+ AP+ AQ Sbjct 1331 AFADAADGTGFSEGAGVLVMQRLGDARRAGRRVLAVLAGSAVNQDGASNGLTAPSGPAQQ 1390 Query 381 GVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPN 440 V+ A A + ++ VEAHGTGT LGD IEA AL +G+ PL +GSIK N Sbjct 1391 QVIAAALADAGITGADVDVVEAHGTGTRLGDPIEAQALLATYGQHHTPDAPLWLGSIKSN 1450 Query 441 IGHLEGAAGIAGLIKAVLMVE--RGSLLPSGGFTE-PNPAIPFTELGLRVVDELQEWPVV 497 IGH + AAG+AG+IK M+E R +LP+ + P+ + ++ +R++ E +EWPVV Sbjct 1451 IGHSQAAAGVAGVIK---MIEAMRHQMLPATLHVDRPSSHVDWSSGTVRLLTEAKEWPVV 1507 Query 498 AGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASAL 557 AGR RRAGVSSFG GTNAHVIVEEA V +D V AD GSGGGVVAWVISGKTASAL Sbjct 1508 AGRLRRAGVSSFGVSGTNAHVIVEEAFPVDSDGVCAGAD--GSGGGVVAWVISGKTASAL 1565 Query 558 AAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPE 617 AAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVV+GQTRDELLAGLAGVVAGRPE Sbjct 1566 AAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVIGQTRDELLAGLAGVVAGRPE 1625 Query 618 AGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRD 677 AGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRD Sbjct 1626 AGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRD 1685 Query 678 VIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCL 737 VIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAH+AGALCL Sbjct 1686 VIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHIAGALCL 1745 Query 738 PDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDA 797 PDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDA Sbjct 1746 PDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDA 1805 Query 798 VSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQL 857 VSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQL Sbjct 1806 VSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQL 1865 Query 858 VADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVS 917 VADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVS Sbjct 1866 VADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVS 1925 Query 918 VPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAP 977 VPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAP Sbjct 1926 VPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAP 1985 Query 978 SVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAA 1037 SVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAA Sbjct 1986 SVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAA 2045 Query 1038 GLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGS 1097 GLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGS Sbjct 2046 GLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGS 2105 Query 1098 SAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALL 1157 SAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALL Sbjct 2106 SAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALL 2165 Query 1158 ADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVE 1217 ADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVE Sbjct 2166 ADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVE 2225 Query 1218 TVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANP 1277 TVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANP Sbjct 2226 TVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANP 2285 Query 1278 SMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIV 1337 SMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIV Sbjct 2286 SMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIV 2345 Query 1338 AKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLV 1397 AKDRIATVENLREERINRWR AAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLV Sbjct 2346 AKDRIATVENLREERINRWRAAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLV 2405 Query 1398 RGPH 1401 RGPH Sbjct 2406 RGPH 2409 >gi|339293459|gb|AEJ45570.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CCDC5079] gi|339297102|gb|AEJ49212.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CCDC5180] Length=1064 Score = 2118 bits (5488), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1062/1063 (99%), Positives = 1063/1063 (100%), Gaps = 0/1063 (0%) Query 339 VLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIG 398 +LQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIG Sbjct 1 MLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIG 60 Query 399 YVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVL 458 YVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVL Sbjct 61 YVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVL 120 Query 459 MVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHV 518 MVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHV Sbjct 121 MVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHV 180 Query 519 IVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVD 578 IVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVD Sbjct 181 IVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVD 240 Query 579 VGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQ 638 VGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQ Sbjct 241 VGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQ 300 Query 639 GSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALF 698 GSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALF Sbjct 301 GSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALF 360 Query 699 AVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGG 758 AVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGG Sbjct 361 AVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGG 420 Query 759 AMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVS 818 AMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVS Sbjct 421 AMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVS 480 Query 819 HAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRF 878 HAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRF Sbjct 481 HAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRF 540 Query 879 GDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQG 938 GDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQG Sbjct 541 GDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQG 600 Query 939 FVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELL 998 FVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELL Sbjct 601 FVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELL 660 Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL Sbjct 661 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 720 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQ 1118 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQ Sbjct 721 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQ 780 Query 1119 ACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQ 1178 ACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQ Sbjct 781 ACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQ 840 Query 1179 REYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGY 1238 REYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGY Sbjct 841 REYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGY 900 Query 1239 SSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIR 1298 SSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIR Sbjct 901 SSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIR 960 Query 1299 VARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRT 1358 VARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRT Sbjct 961 VARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRT 1020 Query 1359 AAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 1401 AAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH Sbjct 1021 AAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 1063 >gi|308371664|ref|ZP_07667220.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu004] gi|308372883|ref|ZP_07430258.2| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu005] gi|308373995|ref|ZP_07667691.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu006] gi|308376384|ref|ZP_07668259.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu008] gi|308335872|gb|EFP24723.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu004] gi|308339449|gb|EFP28300.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu005] gi|308343314|gb|EFP32165.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu006] gi|308351154|gb|EFP40005.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu008] Length=1045 Score = 2048 bits (5306), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1029/1038 (99%), Positives = 1031/1038 (99%), Gaps = 0/1038 (0%) Query 364 QDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFG 423 + G S A +PSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFG Sbjct 7 RTGVSGHAGAVHPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFG 66 Query 424 RKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTEL 483 RKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTEL Sbjct 67 RKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTEL 126 Query 484 GLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGG 543 GLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGG Sbjct 127 GLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGG 186 Query 544 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE 603 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE Sbjct 187 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE 246 Query 604 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV 663 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV Sbjct 247 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV 306 Query 664 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV 723 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV Sbjct 307 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV 366 Query 724 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV 783 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV Sbjct 367 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV 426 Query 784 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG 843 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG Sbjct 427 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG 486 Query 844 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT 903 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT Sbjct 487 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT 546 Query 904 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT 963 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT Sbjct 547 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT 606 Query 964 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV 1023 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV Sbjct 607 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV 666 Query 1024 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE 1083 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE Sbjct 667 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE 726 Query 1084 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS 1143 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS Sbjct 727 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS 786 Query 1144 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD 1203 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD Sbjct 787 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD 846 Query 1204 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV 1263 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV Sbjct 847 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV 906 Query 1264 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA 1323 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA Sbjct 907 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA 966 Query 1324 WEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSE 1383 WEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSE Sbjct 967 WEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSE 1026 Query 1384 AIATEIHDWISGLVRGPH 1401 AIATEIHDWISGLVRGPH Sbjct 1027 AIATEIHDWISGLVRGPH 1044 >gi|308370397|ref|ZP_07421359.2| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis SUMu003] gi|308332057|gb|EFP20908.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis SUMu003] Length=998 Score = 1955 bits (5065), Expect = 0.0, Method: Compositional matrix adjust. Identities = 983/992 (99%), Positives = 985/992 (99%), Gaps = 0/992 (0%) Query 364 QDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFG 423 + G S A +PSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFG Sbjct 7 RTGVSGHAGAVHPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFG 66 Query 424 RKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTEL 483 RKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTEL Sbjct 67 RKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTEL 126 Query 484 GLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGG 543 GLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGG Sbjct 127 GLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGG 186 Query 544 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE 603 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE Sbjct 187 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE 246 Query 604 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV 663 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV Sbjct 247 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV 306 Query 664 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV 723 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV Sbjct 307 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV 366 Query 724 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV 783 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV Sbjct 367 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV 426 Query 784 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG 843 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG Sbjct 427 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG 486 Query 844 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT 903 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT Sbjct 487 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT 546 Query 904 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT 963 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT Sbjct 547 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT 606 Query 964 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV 1023 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV Sbjct 607 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV 666 Query 1024 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE 1083 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE Sbjct 667 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE 726 Query 1084 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS 1143 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS Sbjct 727 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS 786 Query 1144 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD 1203 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD Sbjct 787 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD 846 Query 1204 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV 1263 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV Sbjct 847 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV 906 Query 1264 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA 1323 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA Sbjct 907 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA 966 Query 1324 WEPGRSMAPVLNIVAKDRIATVENLREERINR 1355 WEPGRSMAPVLNIVAKDRIATVENLREERINR Sbjct 967 WEPGRSMAPVLNIVAKDRIATVENLREERINR 998 >gi|167970780|ref|ZP_02553057.1| membrane bound polyketide synthase Pks6 [Mycobacterium tuberculosis H37Ra] Length=970 Score = 1935 bits (5014), Expect = 0.0, Method: Compositional matrix adjust. Identities = 970/970 (100%), Positives = 970/970 (100%), Gaps = 0/970 (0%) Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQ 492 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQ Sbjct 1 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQ 60 Query 493 EWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGK 552 EWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGK Sbjct 61 EWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGK 120 Query 553 TASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVV 612 TASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVV Sbjct 121 TASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVV 180 Query 613 AGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLR 672 AGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLR Sbjct 181 AGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLR 240 Query 673 YPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA 732 YPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA Sbjct 241 YPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA 300 Query 733 GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVIS 792 GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVIS Sbjct 301 GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVIS 360 Query 793 GAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISN 852 GAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISN Sbjct 361 GAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISN 420 Query 853 VTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLAD 912 VTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLAD Sbjct 421 VTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLAD 480 Query 913 AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW 972 AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW Sbjct 481 AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW 540 Query 973 LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG 1032 LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG Sbjct 541 LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG 600 Query 1033 RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI 1092 RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI Sbjct 601 RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI 660 Query 1093 DGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSK 1152 DGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSK Sbjct 661 DGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSK 720 Query 1153 NVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNA 1212 NVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNA Sbjct 721 NVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNA 780 Query 1213 DMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPS 1272 DMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPS Sbjct 781 DMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPS 840 Query 1273 QIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAP 1332 QIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAP Sbjct 841 QIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAP 900 Query 1333 VLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDW 1392 VLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDW Sbjct 901 VLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDW 960 Query 1393 ISGLVRGPHR 1402 ISGLVRGPHR Sbjct 961 ISGLVRGPHR 970 >gi|254549350|ref|ZP_05139797.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|294995910|ref|ZP_06801601.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis 210] Length=970 Score = 1933 bits (5008), Expect = 0.0, Method: Compositional matrix adjust. Identities = 969/969 (100%), Positives = 969/969 (100%), Gaps = 0/969 (0%) Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQ 492 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQ Sbjct 1 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQ 60 Query 493 EWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGK 552 EWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGK Sbjct 61 EWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGK 120 Query 553 TASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVV 612 TASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVV Sbjct 121 TASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVV 180 Query 613 AGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLR 672 AGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLR Sbjct 181 AGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLR 240 Query 673 YPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA 732 YPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA Sbjct 241 YPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVA 300 Query 733 GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVIS 792 GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVIS Sbjct 301 GALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVIS 360 Query 793 GAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISN 852 GAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISN Sbjct 361 GAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISN 420 Query 853 VTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLAD 912 VTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLAD Sbjct 421 VTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLAD 480 Query 913 AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW 972 AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW Sbjct 481 AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFW 540 Query 973 LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG 1032 LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG Sbjct 541 LAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLG 600 Query 1033 RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI 1092 RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI Sbjct 601 RDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI 660 Query 1093 DGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSK 1152 DGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSK Sbjct 661 DGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSK 720 Query 1153 NVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNA 1212 NVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNA Sbjct 721 NVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNA 780 Query 1213 DMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPS 1272 DMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPS Sbjct 781 DMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPS 840 Query 1273 QIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAP 1332 QIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAP Sbjct 841 QIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAP 900 Query 1333 VLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDW 1392 VLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDW Sbjct 901 VLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDW 960 Query 1393 ISGLVRGPH 1401 ISGLVRGPH Sbjct 961 ISGLVRGPH 969 >gi|121636319|ref|YP_976542.1| putative membrane bound polyketide synthase pks6b [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224988791|ref|YP_002643478.1| putative membrane bound polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|121491966|emb|CAL70429.1| Probable membrane bound polyketide synthase pks6b [second part] [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224771904|dbj|BAH24710.1| putative membrane bound polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341600335|emb|CCC63005.1| probable membrane bound polyketide synthase pks6b [second part] [Mycobacterium bovis BCG str. Moreau RDJ] Length=946 Score = 1885 bits (4883), Expect = 0.0, Method: Compositional matrix adjust. Identities = 944/945 (99%), Positives = 945/945 (100%), Gaps = 0/945 (0%) Query 457 VLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNA 516 +LMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNA Sbjct 1 MLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNA 60 Query 517 HVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV 576 HVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV Sbjct 61 HVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV 120 Query 577 VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA 636 VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA Sbjct 121 VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA 180 Query 637 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA 696 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA Sbjct 181 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA 240 Query 697 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPA 756 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPA Sbjct 241 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPA 300 Query 757 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA 816 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA Sbjct 301 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA 360 Query 817 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV 876 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV Sbjct 361 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV 420 Query 877 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA 936 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA Sbjct 421 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA 480 Query 937 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 996 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE Sbjct 481 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 540 Query 997 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV 1056 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV Sbjct 541 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV 600 Query 1057 ELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLF 1116 ELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLF Sbjct 601 ELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLF 660 Query 1117 LQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLS 1176 LQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLS Sbjct 661 LQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLS 720 Query 1177 DQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLS 1236 DQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLS Sbjct 721 DQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLS 780 Query 1237 GYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREV 1296 GYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREV Sbjct 781 GYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREV 840 Query 1297 IRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRW 1356 IRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRW Sbjct 841 IRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRW 900 Query 1357 RTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 1401 RTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH Sbjct 901 RTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 945 >gi|31791583|ref|NP_854076.1| polyketide synthase [Mycobacterium bovis AF2122/97] gi|31617169|emb|CAD93276.1| PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6B [SECOND PART] [Mycobacterium bovis AF2122/97] Length=946 Score = 1883 bits (4878), Expect = 0.0, Method: Compositional matrix adjust. Identities = 943/945 (99%), Positives = 945/945 (100%), Gaps = 0/945 (0%) Query 457 VLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNA 516 +LMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNA Sbjct 1 MLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNA 60 Query 517 HVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV 576 HVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV Sbjct 61 HVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDV 120 Query 577 VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA 636 VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA Sbjct 121 VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA 180 Query 637 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA 696 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA Sbjct 181 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA 240 Query 697 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPA 756 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPA Sbjct 241 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPA 300 Query 757 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA 816 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA Sbjct 301 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA 360 Query 817 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV 876 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV Sbjct 361 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV 420 Query 877 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA 936 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA Sbjct 421 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA 480 Query 937 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 996 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE Sbjct 481 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 540 Query 997 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV 1056 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV Sbjct 541 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV 600 Query 1057 ELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLF 1116 ELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLF Sbjct 601 ELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLF 660 Query 1117 LQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLS 1176 LQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLS Sbjct 661 LQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLS 720 Query 1177 DQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLS 1236 DQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLS Sbjct 721 DQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLS 780 Query 1237 GYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREV 1296 GYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREV Sbjct 781 GYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREV 840 Query 1297 IRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRW 1356 IRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRW Sbjct 841 IRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRW 900 Query 1357 RTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGLVRGPH 1401 RTAAAEAAYSVAEVPGDHFG+MSTSSEAIATEIHDWISGLVRGPH Sbjct 901 RTAAAEAAYSVAEVPGDHFGVMSTSSEAIATEIHDWISGLVRGPH 945 >gi|289760521|ref|ZP_06519899.1| membrane bound polyketide synthase [Mycobacterium tuberculosis GM 1503] gi|289708027|gb|EFD72043.1| membrane bound polyketide synthase [Mycobacterium tuberculosis GM 1503] Length=859 Score = 1712 bits (4434), Expect = 0.0, Method: Compositional matrix adjust. Identities = 857/858 (99%), Positives = 858/858 (100%), Gaps = 0/858 (0%) Query 544 VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE 603 +VAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE Sbjct 1 MVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDE 60 Query 604 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV 663 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV Sbjct 61 LLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAV 120 Query 664 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV 723 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV Sbjct 121 VDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSV 180 Query 724 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV 783 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV Sbjct 181 GELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAV 240 Query 784 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG 843 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG Sbjct 241 NGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVG 300 Query 844 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT 903 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT Sbjct 301 LPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLT 360 Query 904 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT 963 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT Sbjct 361 SLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPT 420 Query 964 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV 1023 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV Sbjct 421 YAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVV 480 Query 1024 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE 1083 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE Sbjct 481 CEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTE 540 Query 1084 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS 1143 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS Sbjct 541 LAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMS 600 Query 1144 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD 1203 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD Sbjct 601 SPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFD 660 Query 1204 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV 1263 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV Sbjct 661 SSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGV 720 Query 1264 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA 1323 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA Sbjct 721 ALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQA 780 Query 1324 WEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSE 1383 WEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSE Sbjct 781 WEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSE 840 Query 1384 AIATEIHDWISGLVRGPH 1401 AIATEIHDWISGLVRGPH Sbjct 841 AIATEIHDWISGLVRGPH 858 >gi|289756474|ref|ZP_06515852.1| predicted protein [Mycobacterium tuberculosis T85] gi|289712038|gb|EFD76050.1| predicted protein [Mycobacterium tuberculosis T85] Length=813 Score = 1617 bits (4186), Expect = 0.0, Method: Compositional matrix adjust. Identities = 808/808 (100%), Positives = 808/808 (100%), Gaps = 0/808 (0%) Query 594 AVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAY 653 AVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAY Sbjct 5 AVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAY 64 Query 654 PVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGV 713 PVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGV Sbjct 65 PVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGV 124 Query 714 RPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPM 773 RPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPM Sbjct 125 RPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPM 184 Query 774 LGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEF 833 LGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEF Sbjct 185 LGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEF 244 Query 834 TAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRF 893 TAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRF Sbjct 245 TAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRF 304 Query 894 IEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSG 953 IEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSG Sbjct 305 IEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSG 364 Query 954 YRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSAD 1013 YRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSAD Sbjct 365 YRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGRSAD 424 Query 1014 EQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPAT 1073 EQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPAT Sbjct 425 EQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPAT 484 Query 1074 AIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVA 1133 AIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVA Sbjct 485 AIFDHPTPTELAQYLITQIDGHGSSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVA 544 Query 1134 LASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHS 1193 LASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHS Sbjct 545 LASNTRERMSSPVRNNVSKNVALLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHS 604 Query 1194 VYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLS 1253 VYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLS Sbjct 605 VYSLTLPGFDSSDALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLS 664 Query 1254 VKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTA 1313 VKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTA Sbjct 665 VKHQRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTA 724 Query 1314 AATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGD 1373 AATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGD Sbjct 725 AATYAAIFQAWEPGRSMAPVLNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGD 784 Query 1374 HFGMMSTSSEAIATEIHDWISGLVRGPH 1401 HFGMMSTSSEAIATEIHDWISGLVRGPH Sbjct 785 HFGMMSTSSEAIATEIHDWISGLVRGPH 812 >gi|183980730|ref|YP_001849021.1| polyketide synthase Pks6 [Mycobacterium marinum M] gi|183174056|gb|ACC39166.1| polyketide synthase Pks6 [Mycobacterium marinum M] Length=2414 Score = 1430 bits (3701), Expect = 0.0, Method: Compositional matrix adjust. Identities = 759/1155 (66%), Positives = 868/1155 (76%), Gaps = 35/1155 (3%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDG +AD LQ+WF Y++ C EV+LD+P+RDLGL SIDVLAIPG+L D G C Sbjct 1 MTDGLHSADALQEWFTHYIAARTGCDSAEVNLDLPLRDLGLGSIDVLAIPGELSDVLGIC 60 Query 61 IPDLAVWDNPSANDLIDSLL----NQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGC 116 +PDLAVWDNPSA+D+I S+L +QRSADS G A G G NEP+AVIG+ C Sbjct 61 VPDLAVWDNPSAHDVIKSVLGGDGSQRSADS---DTGCA---VLGNGPTNEPIAVIGMAC 114 Query 117 RFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNA-----GTFAES--GGFLKDVAGFDNR 169 RF G + G LWDFL EKK AIT YP R A G E+ G FL+DV GFDN+ Sbjct 115 RFSGQVHGVGPLWDFLAEKKSAITEYPARRLGAAAADWLGDEQETIYGCFLEDVEGFDNK 174 Query 170 FFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSAS 229 FFDIPPDEA MDPQQRLLLE SW ALEHAGI+P++L+LS TGVFVGVSSTDYVRL+ Sbjct 175 FFDIPPDEAALMDPQQRLLLETSWAALEHAGILPKTLKLSHTGVFVGVSSTDYVRLLFPG 234 Query 230 AQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDI 289 + K TIWDNTGGSSSIIANR+SYFLD+ GPS+VIDTACSSSLVA HLA +SL++ +CD+ Sbjct 235 GR-KPTIWDNTGGSSSIIANRLSYFLDVNGPSLVIDTACSSSLVAAHLARKSLASGECDL 293 Query 290 ALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLE 349 A+V GTNVLISPE W GF+EAG++S TG C AFD ADGMVRGEGCGV+VL+RLSDAR Sbjct 294 AVVAGTNVLISPEVWRGFQEAGVVSPTGSCRAFDARADGMVRGEGCGVVVLERLSDARRA 353 Query 350 GRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSL 409 GR +LA+LTGSAVNQDG+SNGIMAPNP AQI VL++ACK A +DP EI YVEAHGTGTS+ Sbjct 354 GRTVLAVLTGSAVNQDGRSNGIMAPNPRAQISVLDSACKCADIDPAEIDYVEAHGTGTSV 413 Query 410 GDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSG 469 GDRIEAHALG VFGR R + PLMIGSIKPNIGHLEGAAGIAGLIK VLM++RG LLPSG Sbjct 414 GDRIEAHALGQVFGRGRQAAKPLMIGSIKPNIGHLEGAAGIAGLIKTVLMLQRGQLLPSG 473 Query 470 GFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGAD 529 F PNP IPF ELGL VV+E QEWP V GRPRRAGVSSFGFGGTNAHVIVE+A + Sbjct 474 AFEVPNPNIPFAELGLAVVEEFQEWPAVVGRPRRAGVSSFGFGGTNAHVIVEQAVERVVE 533 Query 530 TVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSV 589 V G GV+AWV+S +TA+ + AQAGRL +VRA LD DVGYSLV+TRS+ Sbjct 534 RVVE------VGPGVLAWVVSARTAAGVGAQAGRLLEFVRAGRELDAGDVGYSLVTTRSL 587 Query 590 FDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSEL 649 F+HRAVVVG RDELLAGLA VV GRP GV GV P GKT FVF GQG+QWLGMG EL Sbjct 588 FEHRAVVVGAGRDELLAGLAEVVEGRPGVGVASGVAMPGGKTVFVFPGQGAQWLGMGREL 647 Query 650 YAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLM 709 A YPVFA A DAVV ELDRHL PLR+V+WG D +LLNTTEFAQPALFAVEVALYRLL Sbjct 648 CAGYPVFAAAFDAVVAELDRHLARPLREVVWGADAELLNTTEFAQPALFAVEVALYRLLE 707 Query 710 SWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDE 769 SWG+RPGLV+GHSVGEL+AAHV+G L L DAA+LV RGRLMQALP GG M+AVQA E E Sbjct 708 SWGMRPGLVMGHSVGELSAAHVSGVLDLADAALLVVMRGRLMQALPGGGVMYAVQAGEQE 767 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 + P+LG VS+AAVNGP SVV+SGA +AVS + DRL QGRRV RLAVSHAFHS LMEPM Sbjct 768 LRPLLGEQVSVAAVNGPGSVVLSGAREAVSVVVDRLAAQGRRVRRLAVSHAFHSVLMEPM 827 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + +F AVA E+ G P IPVISNVTGQLVA+D+ SADYW RHIR VRF DSV AH AG Sbjct 828 LEQFRAVADEVYAGRPAIPVISNVTGQLVAEDYGSADYWVRHIREAVRFADSVCFAHSAG 887 Query 890 ASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWAS 949 A+RF+EVGP GGLTSLIE SLA +V+VPTLRKDRPEP +V+ A AQ FV G G+DWAS Sbjct 888 ATRFVEVGPAGGLTSLIEESLAQVSVVAVPTLRKDRPEPFAVVGAVAQAFVRGAGVDWAS 947 Query 950 VFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGG------AELLASSGF 1003 V +G +RV LPTYAF H++FWLA V GQ+ A + G A GF Sbjct 948 VLAGCGGQRVGLPTYAFAHERFWLADRFGVGQQVCVGQVLADEAGPGAHEAAGAAVGQGF 1007 Query 1004 AARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLT 1063 AARL G S EQ AA + +VCEH AAVLGRDGAA LDAGQAF+D+G SLSAVELRNRL Sbjct 1008 AARLQGLSDAEQQAAVLAMVCEHTAAVLGRDGAAQLDAGQAFSDAGLTSLSAVELRNRLK 1067 Query 1064 AVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSA-AAAANPAERIDALTDLFLQAC-- 1120 +T VTL AT FD+PTPT+LA +L++ + SA AAA RID + C Sbjct 1068 TLTGVTLSATTAFDYPTPTQLADHLLSHLHHQNRSAPAAAVRTRVRIDEPIAIVGMGCRY 1127 Query 1121 --DAGRDADGWKMVA 1133 A W++VA Sbjct 1128 PGGVSSPAQLWQLVA 1142 Score = 1415 bits (3664), Expect = 0.0, Method: Compositional matrix adjust. Identities = 784/1382 (57%), Positives = 953/1382 (69%), Gaps = 41/1382 (2%) Query 38 DLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADR 97 D GL S+ + + L G + +D P+ L D LL+ + R + A R Sbjct 1051 DAGLTSLSAVELRNRLKTLTGVTLSATTAFDYPTPTQLADHLLSHLHHQN-RSAPAAAVR 1109 Query 98 NTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DRGF--------- 147 R I+EP+A++G+GCR+PG + P +LW + I +P DRG+ Sbjct 1110 T---RVRIDEPIAIVGMGCRYPGGVSSPAQLWQLVASGGDVIGEFPPDRGWDIERLFDPD 1166 Query 148 --TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPES 205 T+ GGF+ DVA FD FF I P EAL MDPQQRLLLE SWEALE AGI P++ Sbjct 1167 PDALGKTYTRHGGFVSDVADFDPGFFGISPGEALAMDPQQRLLLETSWEALEDAGIDPQA 1226 Query 206 LRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVID 265 LR S TGVFVG+ Y L ++ AQ + +TG +S+ + RISY L + GP+I +D Sbjct 1227 LRGSSTGVFVGIYGDGY-GLGTSQAQW----YADTGHITSVASGRISYCLGLAGPAISVD 1281 Query 266 TACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKS 325 TACSSSLVA+HLA SL +CD+AL GG+ VL +P + GF L+ G C AF + Sbjct 1282 TACSSSLVALHLAANSLRAGECDLALAGGSTVLATPSIFIGFSRQRGLATDGRCKAFADA 1341 Query 326 ADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLEN 385 ADG EG G++VLQRLSDAR G+ +LAIL GSAVNQDG SNG+ AP+ AQ V+ Sbjct 1342 ADGTGFSEGAGMLVLQRLSDARRAGQPVLAILAGSAVNQDGASNGLTAPSGPAQQRVISA 1401 Query 386 ACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLE 445 A A + ++ VEAHGTGT LGD IEA AL +GR PL +GSIK N+GH + Sbjct 1402 ALSDAGITGADVDVVEAHGTGTRLGDPIEAQALLATYGRDHTPDAPLWLGSIKSNMGHSQ 1461 Query 446 GAAGIAGLIKAVLMVE--RGSLLPSG-GFTEPNPAIPFTELGLRVVDELQEWPVVAGRPR 502 AAG+AG+IK MVE R LLP+ +P+ + ++ ++++ E +EWP V GRPR Sbjct 1462 AAAGVAGVIK---MVEAMRHQLLPATLHIDQPSAHVDWSPGTVQLLTEAREWPAVVGRPR 1518 Query 503 RAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAG 562 RAGVSSFG GTNAHVIVE+A + V G GV+AWV+S +TA+ + AQAG Sbjct 1519 RAGVSSFGVSGTNAHVIVEQAVERVVERVVE------VGPGVLAWVVSARTAAGVGAQAG 1572 Query 563 RLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVC 622 RL +VRA LD DVGYSLV+TRS+F+HRAVVVG RDELLAGLA VV GRP GV Sbjct 1573 RLLEFVRAGRELDAGDVGYSLVTTRSLFEHRAVVVGAGRDELLAGLAEVVEGRPGVGVAS 1632 Query 623 GVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGH 682 GV P GKT FVF GQG+QWLGMG EL A YPVFA A DAVV ELDRHL PLR+V+WG Sbjct 1633 GVAMPGGKTVFVFPGQGAQWLGMGRELCAGYPVFAAAFDAVVAELDRHLARPLREVVWGA 1692 Query 683 DQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAM 742 D +LLNTTEFAQPALFAVEVALYRLL SWG+RPGLV+GHSVGEL+AAHV+G L L DAA+ Sbjct 1693 DAELLNTTEFAQPALFAVEVALYRLLESWGMRPGLVMGHSVGELSAAHVSGVLDLADAAL 1752 Query 743 LVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIA 802 LV RGRLMQALP GG M+AVQA E E+ P+LG VS+AAVNGP SVV+SGA +AVS + Sbjct 1753 LVVMRGRLMQALPGGGVMYAVQAGEQELRPLLGEQVSVAAVNGPGSVVLSGAREAVSVVV 1812 Query 803 DRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDF 862 DRL QGRRV RLAVSHAFHS LMEPM+ +F AVA E+ G P IPVISNVTGQLVA+D+ Sbjct 1813 DRLAAQGRRVRRLAVSHAFHSVLMEPMLEQFRAVADEVYAGRPAIPVISNVTGQLVAEDY 1872 Query 863 ASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLR 922 SADYW RHIR VRF DSV AH AGA+RF+EVGP GGLTSLIE SLA +V+VPTLR Sbjct 1873 GSADYWVRHIREAVRFADSVCFAHSAGATRFVEVGPAGGLTSLIEESLAQVSVVAVPTLR 1932 Query 923 KDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDP 982 KDRPEP +V+ A AQ FV G G+DWASV +G +RV LPTYAF H++FWLA V Sbjct 1933 KDRPEPFAVVGAVAQAFVRGAGVDWASVLAGCGGQRVGLPTYAFAHERFWLADRFGVGQQ 1992 Query 983 TAAGQIGASDGG------AELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGA 1036 GQ+ A + G A GFAARL G S EQ AA + +VCEH AAVLGRDGA Sbjct 1993 VCVGQVLADEAGPGAHEAAGAAVGQGFAARLQGLSDAEQQAAVLAMVCEHTAAVLGRDGA 2052 Query 1037 AGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG 1096 A LDAGQAF+D+G SLSAVELRNRL +T VTL AT FD+PTPT+LA +L++ + H Sbjct 2053 AQLDAGQAFSDAGLTSLSAVELRNRLKTLTGVTLSATTAFDYPTPTQLADHLLSHL--HH 2110 Query 1097 SSAAAAANPAERIDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNNVSKNVAL 1156 + A +R+DALTDLFLQ CDAGRD DGW++VALA+N RERM++PV K V L Sbjct 2111 QNPTGATPELDRVDALTDLFLQTCDAGRDDDGWQIVALAANGRERMTTPVPKREWKEVVL 2170 Query 1157 LADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMIV 1216 LA G SDV V+C+PTLTVLS Y D+A AM GRHSV++L+LPGFD DALPQ+ ++++ Sbjct 2171 LAGGRSDVAVVCLPTLTVLSSPHAYLDVARAMAGRHSVHALSLPGFDPDDALPQDREVVL 2230 Query 1217 ETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIAN 1276 E + AI+ VG VL+GYSSGGVLA+AL S+L+ +HQR PLGVALIDTYLPSQI N Sbjct 2231 EGAAQAILHAVGDHPHLVLAGYSSGGVLAHALGSYLAERHQRTPLGVALIDTYLPSQIVN 2290 Query 1277 PSMNEGFSPNDTGKGLSREVIRVARMLNRLTATRLTAAATYAAIFQAWEPGRSMAPVLNI 1336 + N+TG SR V +AR L++L ATRLTAAA+YAA+F WEP S P+LN+ Sbjct 2291 ADNPDQVGVNETGALFSRRVTSMARELDQLNATRLTAAASYAALFGTWEPVVSAVPLLNM 2350 Query 1337 VAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWISGL 1396 +A D A E +R ERINRWR A AEA+YSV EVPGDHF M++TSS+A T +H WISGL Sbjct 2351 IAMDETAACERVRAERINRWRVATAEASYSVVEVPGDHFDMITTSSDATTTALHGWISGL 2410 Query 1397 VR 1398 +R Sbjct 2411 IR 2412 >gi|289756473|ref|ZP_06515851.1| polyketide synthase [Mycobacterium tuberculosis T85] gi|289712037|gb|EFD76049.1| polyketide synthase [Mycobacterium tuberculosis T85] Length=569 Score = 999 bits (2583), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/491 (99%), Positives = 489/491 (99%), Gaps = 0/491 (0%) Query 28 NEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS 87 NEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS Sbjct 15 NEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS 74 Query 88 LRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGF 147 LRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGF Sbjct 75 LRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGF 134 Query 148 TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLR 207 TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLR Sbjct 135 TNAGTFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLR 194 Query 208 LSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTA 267 LSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTA Sbjct 195 LSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTA 254 Query 268 CSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSAD 327 CSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSAD Sbjct 255 CSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSAD 314 Query 328 GMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENAC 387 GMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENAC Sbjct 315 GMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENAC 374 Query 388 KSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGA 447 KSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGA Sbjct 375 KSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGA 434 Query 448 AGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVS 507 AGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVS Sbjct 435 AGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVS 494 Query 508 SFGFGGTNAHV 518 SFGFGGTNA Sbjct 495 SFGFGGTNARC 505 >gi|31791582|ref|NP_854075.1| polyketide synthase [Mycobacterium bovis AF2122/97] gi|121636318|ref|YP_976541.1| putative membrane bound polyketide synthase pks6a [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224988790|ref|YP_002643477.1| putative membrane bound polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|31617168|emb|CAD93275.1| PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6A [FIRST PART] [Mycobacterium bovis AF2122/97] gi|121491965|emb|CAL70428.1| Probable membrane bound polyketide synthase pks6a [first part] [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224771903|dbj|BAH24709.1| putative membrane bound polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341600334|emb|CCC63004.1| probable membrane bound polyketide synthase pks6a [first part] [Mycobacterium bovis BCG str. Moreau RDJ] Length=460 Score = 939 bits (2427), Expect = 0.0, Method: Compositional matrix adjust. Identities = 456/456 (100%), Positives = 456/456 (100%), Gaps = 0/456 (0%) Query 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC Sbjct 1 MTDGSVTADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFC 60 Query 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG Sbjct 61 IPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPG 120 Query 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR Sbjct 121 DIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDNRFFDIPPDEALR 180 Query 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT Sbjct 181 MDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNT 240 Query 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS Sbjct 241 GGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLIS 300 Query 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS Sbjct 301 PEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGS 360 Query 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM Sbjct 361 AVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGM 420 Query 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKA 456 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKA Sbjct 421 VFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKA 456 >gi|339298599|gb|AEJ50709.1| polyketide synthase Pks12 [Mycobacterium tuberculosis CCDC5180] Length=2617 Score = 892 bits (2304), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 448 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 507 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 508 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 562 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 563 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 622 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 623 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 678 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 679 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 738 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 739 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 798 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 799 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 857 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 858 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 916 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 917 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 968 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 969 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 1027 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 1028 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 1087 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 1088 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 1147 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 1148 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 1207 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 1208 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 1267 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 1268 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 1327 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 1328 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 1385 Query 972 WLA 974 WL+ Sbjct 1386 WLS 1388 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 418 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 477 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 478 TGLSLSPTLIFDYPTPNRLASYIRTELAG 506 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 2443 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 2502 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 2503 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 2553 >gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] gi|148721791|gb|ABR06416.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] Length=4151 Score = 891 bits (2303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 609 bits (1570), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobacterium bovis AF2122/97] gi|31618823|emb|CAD96927.1| Probable polyketide synthase pks12 [Mycobacterium bovis AF2122/97] Length=4151 Score = 891 bits (2303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 609 bits (1570), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 74.7 bits (182), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 44/104 (43%), Positives = 61/104 (59%), Gaps = 2/104 (1%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G DEQ A +++V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 3984 RLHGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQDLGFDSLTAVEMRNRLKSA 4043 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 T ++L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4044 TGLSLSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_10901 [Mycobacterium tuberculosis KZN 4207] gi|313658946|ref|ZP_07815826.1| hypothetical protein MtubKV_11016 [Mycobacterium tuberculosis KZN V2475] Length=4152 Score = 891 bits (2303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1983 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2042 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2043 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2097 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2098 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2157 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2158 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2213 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2214 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2273 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2274 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2333 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2334 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2392 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2393 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2451 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2452 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2503 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2504 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2562 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2563 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2622 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2623 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2682 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2683 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2742 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2743 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2802 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2803 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2862 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2863 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2920 Query 972 WLA 974 WL+ Sbjct 2921 WLS 2923 Score = 606 bits (1562), Expect = 1e-170, Method: Compositional matrix adjust. Identities = 397/948 (42%), Positives = 544/948 (58%), Gaps = 52/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F +GGF+ V FD FF + P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF GV + Y A + + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFR 174 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 175 LTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 234 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 235 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 294 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 295 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 354 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 355 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 412 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 413 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 465 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 466 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 523 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 524 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 583 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 584 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 643 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 644 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 702 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 703 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 761 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 762 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 821 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 822 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 881 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 882 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 926 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1953 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2012 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2013 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2041 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3978 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4037 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4038 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4088 >gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|253320398|gb|ACT25001.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|328458652|gb|AEB04075.1| polyketide synthase pks12 [Mycobacterium tuberculosis KZN 4207] gi|344219874|gb|AEN00505.1| polyketide synthase pks12 [Mycobacterium tuberculosis CTRI-2] Length=4152 Score = 891 bits (2302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1983 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2042 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2043 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2097 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2098 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2157 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2158 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2213 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2214 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2273 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2274 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2333 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2334 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2392 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2393 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2451 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2452 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2503 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2504 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2562 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2563 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2622 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2623 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2682 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2683 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2742 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2743 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2802 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2803 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2862 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2863 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2920 Query 972 WLA 974 WL+ Sbjct 2921 WLS 2923 Score = 606 bits (1562), Expect = 1e-170, Method: Compositional matrix adjust. Identities = 393/946 (42%), Positives = 541/946 (58%), Gaps = 48/946 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F +GGF+ V FD FF + P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF GV + Y A + + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFR 174 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 175 LTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 234 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 235 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 294 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 295 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 354 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 355 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 412 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 413 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 465 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 466 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 523 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 524 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 583 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 584 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 643 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPML 774 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ D+ +L Sbjct 644 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLL 703 Query 775 ---GHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIA 831 G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 704 APFGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRG 763 Query 832 EFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGAS 891 + + S VTG + ADYW R++R V F +VR+A G Sbjct 764 PLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYR 823 Query 892 RFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLD 946 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ ++ Sbjct 824 TFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVN 883 Query 947 WASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 884 WRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 926 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1953 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2012 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2013 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2041 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3978 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4037 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4038 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4088 >gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289574727|ref|ZP_06454954.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339632088|ref|YP_004723730.1| polyketide synthase [Mycobacterium africanum GM041182] gi|124601277|gb|EAY60287.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289539158|gb|EFD43736.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339331444|emb|CCC27133.1| putative polyketide synthase pks12 [Mycobacterium africanum GM041182] Length=4151 Score = 891 bits (2302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 608 bits (1569), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycobacterium tuberculosis 210] Length=4151 Score = 891 bits (2302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 608 bits (1569), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] gi|289420626|gb|EFD17827.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] Length=4151 Score = 891 bits (2302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 608 bits (1569), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990428|ref|YP_002645115.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|121493581|emb|CAL72055.1| Probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224773541|dbj|BAH26347.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601971|emb|CCC64645.1| probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Moreau RDJ] Length=4151 Score = 891 bits (2302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 608 bits (1569), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.9 bits (180), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 63/111 (57%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T ++L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLSLSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|298495345|gb|EFI30639.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=4151 Score = 890 bits (2301), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 612 bits (1577), Expect = 2e-172, Method: Compositional matrix adjust. Identities = 400/948 (43%), Positives = 548/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ DVA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDDVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|340627059|ref|YP_004745511.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] gi|340005249|emb|CCC44403.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] Length=4154 Score = 890 bits (2301), Expect = 0.0, Method: Compositional matrix adjust. Identities = 503/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1985 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2044 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2045 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPGDR 2099 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2100 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2159 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2160 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2215 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2216 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2275 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2276 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2335 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2336 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2394 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2395 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2453 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2454 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2505 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2506 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2564 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2565 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2624 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2625 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2684 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2685 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2744 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI +IS Sbjct 2745 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGIIS 2804 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2805 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2864 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2865 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2922 Query 972 WLA 974 WL+ Sbjct 2923 WLS 2925 Score = 615 bits (1585), Expect = 3e-173, Method: Compositional matrix adjust. Identities = 405/952 (43%), Positives = 550/952 (58%), Gaps = 61/952 (6%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + E + I+ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVAEGRDVISGFPTDRGWDLAGLFDPDPDARHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + +ADG+ EG G++ L+RLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYGGAADGVGWSEGGGMLALERLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G PAGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATPAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S VR Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVR 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIALCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPV----ISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSA 885 AE G+ P S VTG + ADYW R++R V F +VR+A Sbjct 761 RGPL----AEALSGIEPRPTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNA 816 Query 886 HCAGASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFV 940 G FIE P L + +E + A D++ + VPTL + + + A FV Sbjct 817 CEQGYRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSTASAFV 876 Query 941 SGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 +G+ +DW G VELPTYAF ++FWL+ S +D G +GAS+ Sbjct 877 AGVAVDWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADAFGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1955 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2014 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2015 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2043 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3980 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4039 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4040 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4090 >gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_11001 [Mycobacterium tuberculosis KZN R506] Length=4152 Score = 890 bits (2300), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 638/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1983 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2042 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2043 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2097 Query 146 GFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG F +GGF+ V FD FF + P EAL MDPQ R+LLE+SWE Sbjct 2098 GWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWE 2157 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2158 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2213 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2214 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2273 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2274 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2333 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2334 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2392 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2393 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2451 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2452 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2503 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2504 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2562 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2563 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2622 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2623 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2682 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2683 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2742 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2743 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2802 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2803 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2862 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2863 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2920 Query 972 WLA 974 WL+ Sbjct 2921 WLS 2923 Score = 606 bits (1563), Expect = 1e-170, Method: Compositional matrix adjust. Identities = 397/948 (42%), Positives = 544/948 (58%), Gaps = 52/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F +GGF+ V FD FF + P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF GV + Y A + + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFR 174 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 175 LTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 234 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 235 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 294 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 295 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 354 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 355 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 412 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 413 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 465 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 466 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 523 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 524 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 583 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 584 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 643 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 644 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 702 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 703 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 761 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 762 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 821 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 822 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 881 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 882 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 926 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1953 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2012 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2013 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2041 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3978 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4037 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4038 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4088 >gi|289750639|ref|ZP_06510017.1| polyketide synthase pks8 [Mycobacterium tuberculosis T92] gi|289691226|gb|EFD58655.1| polyketide synthase pks8 [Mycobacterium tuberculosis T92] Length=1072 Score = 890 bits (2300), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 639/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 116 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 175 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 176 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 230 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 231 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 290 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 291 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 346 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 347 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 406 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 407 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 466 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 467 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 525 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 526 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 584 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 585 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 636 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 637 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 695 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 696 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 755 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 756 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 815 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 816 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 875 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 876 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 935 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 936 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 995 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 996 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 1053 Query 972 WLA 974 WL+ Sbjct 1054 WLS 1056 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 86 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 145 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 146 TGLSLSPTLIFDYPTPNRLASYIRTELAG 174 >gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] gi|2896785|emb|CAA17262.1| Probable polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] Length=4151 Score = 890 bits (2299), Expect = 0.0, Method: Compositional matrix adjust. Identities = 503/963 (53%), Positives = 638/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQ R+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 609 bits (1571), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|289554169|ref|ZP_06443379.1| polyketide synthase Pks12 [Mycobacterium tuberculosis KZN 605] gi|289438801|gb|EFD21294.1| polyketide synthase Pks12 [Mycobacterium tuberculosis KZN 605] Length=2730 Score = 890 bits (2299), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/963 (53%), Positives = 638/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 561 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 620 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 621 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 675 Query 146 GFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG F +GGF+ V FD FF + P EAL MDPQ R+LLE+SWE Sbjct 676 GWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWE 735 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 736 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 791 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 792 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 851 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 852 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 911 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 912 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 970 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 971 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 1029 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 1030 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 1081 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 1082 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 1140 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 1141 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 1200 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 1201 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 1260 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 1261 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 1320 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 1321 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 1380 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 1381 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 1440 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 1441 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 1498 Query 972 WLA 974 WL+ Sbjct 1499 WLS 1501 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 531 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 590 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 591 TGLSLSPTLIFDYPTPNRLASYIRTELAG 619 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 2556 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 2615 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 2616 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 2666 >gi|118463709|ref|YP_881643.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118164996|gb|ABK65893.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=4171 Score = 889 bits (2297), Expect = 0.0, Method: Compositional matrix adjust. Identities = 504/991 (51%), Positives = 655/991 (67%), Gaps = 39/991 (3%) Query 11 LQKWFREYLSTHIECHPNE-VSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDN 69 L + R +++T + E + D ++LG S+ + + L G + ++D Sbjct 1977 LLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDY 2036 Query 70 PSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLW 129 P+ N L + + + +H R T ++P+A++G+ CRFPG +D PE LW Sbjct 2037 PTPNALAGYIRTELAGAPQETTHAPVVRATD-----DDPIAIVGMSCRFPGGVDSPEALW 2091 Query 130 DFLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDE 177 + E + ++ +P DRG+ AG + +GGF+ +VA FD FF I P E Sbjct 2092 QMVAEGRDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGIAPSE 2151 Query 178 ALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIW 237 AL MDPQQR+ LE+SWEALE AGI P LR S TG+F GV + Y A + + Sbjct 2152 ALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGY----GMGAAPIAEGF 2207 Query 238 DNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNV 297 TG SSS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 2208 RLTGQSSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTV 2267 Query 298 LISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAIL 357 +P+ + F LS G C A+ +ADG EG G++V++RLSDAR G +LA++ Sbjct 2268 NATPDIFVEFSRMRGLSVDGRCKAYAGAADGTGFSEGGGMLVVERLSDARRLGHPVLAVV 2327 Query 358 TGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHA 417 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA A Sbjct 2328 RGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQA 2387 Query 418 LGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSG-GFTEPNP 476 L +G+ R PL +GSIK N+GH + AAG+AG+IK VL + R LLP+ EP+P Sbjct 2388 LLATYGQDR--GQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDEPSP 2444 Query 477 AIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRAD 536 + ++ + ++ E Q WP RPRRAGVSSFG GTNAHVI+E +V A Sbjct 2445 HVDWSAGAVSLLTEAQPWP--GERPRRAGVSSFGISGTNAHVIIEAVPAVEP------AH 2496 Query 537 VGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVV 596 V+ WV+S K+A+AL AQA RL YVRA+ LD+ DVG++L + R+ F+HRAVV Sbjct 2497 ADAPALPVLPWVVSAKSAAALRAQAARLAEYVRAQGELDIADVGWTL-AGRATFEHRAVV 2555 Query 597 VGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVF 656 VG RD LLAGL + A P A ++ GV PAGKT FVF GQGSQ LGMG +L+A YPVF Sbjct 2556 VGGDRDRLLAGLDELAADDPAASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVF 2615 Query 657 AEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPG 716 AEA DAVV ELDRHL PLRDVIWG D+++LN+TEFAQPALFAVEVAL+RLL SWGVRP Sbjct 2616 AEAFDAVVAELDRHLLRPLRDVIWGDDENVLNSTEFAQPALFAVEVALFRLLESWGVRPD 2675 Query 717 LVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGH 776 V+GHS+GEL+AAHVAG L L +AA+LVAARGR MQALP GGAM AVQA E +V P+LG Sbjct 2676 FVMGHSIGELSAAHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLGP 2735 Query 777 DVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAV 836 DV IAAVNGPA+VVISG HDA AIA+RLR +G RVHRL+VSHAFHS LMEPMI EF V Sbjct 2736 DVGIAAVNGPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTV 2795 Query 837 AAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEV 896 AA L++ P IP+ISN+TGQ ADDF S +YW H+R VRF DSVR A AGA+RF+EV Sbjct 2796 AAGLAIDKPVIPIISNLTGQPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFLEV 2855 Query 897 GPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW-ASVFSGYR 955 GP GLT+ IE +LADA +V+V LRKDRPEPV+++ A AQG+V GM +DW ++ +G+ Sbjct 2856 GPSSGLTAAIEETLADAPVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALGTGH- 2914 Query 956 PKRVELPTYAFQHQKFWLAPAPSVSDPTAAG 986 V+LPTYAF ++FWL+ + SD G Sbjct 2915 --LVDLPTYAFDRRRFWLSGDGAASDAAGLG 2943 Score = 613 bits (1581), Expect = 7e-173, Method: Compositional matrix adjust. Identities = 395/944 (42%), Positives = 552/944 (59%), Gaps = 48/944 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 2 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEALWQ 59 Query 131 FLTEKKCAITAYP-DRGFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEA 178 + E + I+ +P DRG+ A + +GGF+ +VA FD FF I P EA Sbjct 60 MVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGFVDNVADFDPAFFGIAPSEA 119 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 120 LAMDPQHRMLLELSWEALERAGIDPSGLRGSATGVFAGLIVQGYGMLA-----EEIEGYR 174 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 175 LTGMTSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVN 234 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C A+ +ADG+ EG ++V++RLSDAR G +LA++ Sbjct 235 ATPTVFVEFSRHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR 294 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 295 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 354 Query 419 GMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSG-GFTEPNPA 477 +G+ R PL +GSIK N+GH + AAG+AG+IK VL + R LLP+ EP+P Sbjct 355 LATYGQDR--GQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDEPSPH 411 Query 478 IPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADV 537 + ++ + ++ E Q WP RPRRAGVSSFG GTNAHVI+E +V A Sbjct 412 VDWSAGAVSLLTEAQPWP--GERPRRAGVSSFGISGTNAHVIIEAVPAVEP------AHA 463 Query 538 GGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVV 597 V+ WV+S K+A+AL AQA RL YVRA+ LD+ DVG++L + R+ F+HRAVVV Sbjct 464 DAPALPVLPWVVSAKSAAALRAQAARLAEYVRAQGELDIADVGWTL-AGRATFEHRAVVV 522 Query 598 GQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFA 657 G RD LLAGL + A P A ++ GV PAGKT FVF GQGSQWLGM +EL PVFA Sbjct 523 GGDRDRLLAGLDELAADDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFA 582 Query 658 EALDAVVDELDRHLRYPLRDVIWGHDQDL-LNTTEFAQPALFAVEVALYRLLMSWGVRPG 716 + + A + + + L D + G ++ + QPALFAV V+L L S GV P Sbjct 583 QHIQACEEAFAEFVDWSLIDALRGAPGAAGMDRVDVVQPALFAVMVSLAELWKSVGVSPD 642 Query 717 LVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQA---REDEVAPM 773 V+GHS GE+AAA+VAGAL L DAA +V R +L+++L G M ++ R E+ Sbjct 643 AVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAP 702 Query 774 LGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEF 833 G+ VSIAAVNG ++VV+SG A+ +A R R+ V +A HS +E + + Sbjct 703 YGNRVSIAAVNGRSAVVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDL 762 Query 834 TAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRF 893 + I S VTG + ADYW R+IR V+F +VRSA G F Sbjct 763 AQALTGIEPRSSRIAFFSTVTGNRLDTAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRTF 822 Query 894 IEVGPGGGLTSLIEASL-----ADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWA 948 IE P L + IE ++ D + + +PTL +D +T+AA FV+G+ + W Sbjct 823 IESSPHPALVAGIEDTVNDSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWR 882 Query 949 SVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 V G VELPTYAF ++FWL+ + +D + G +G S+ Sbjct 883 GVLDGA--GFVELPTYAFDRRRFWLSGEGAAADASGLG-LGTSE 923 Score = 79.0 bits (193), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 42/89 (48%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A +E+V H A VLG A +D +AF + GF+SL+AVE+RNRL Sbjct 1964 RLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTA 2023 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T + L T IFD+PTP LA Y+ T++ G Sbjct 2024 TGLALSPTLIFDYPTPNALAGYIRTELAG 2052 Score = 75.9 bits (185), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 43/109 (40%), Positives = 59/109 (55%), Gaps = 0/109 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V + A VLG + +AF + GF+SL+AVE+ Sbjct 3996 SKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIHPDRAFQELGFDSLTAVEM 4055 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE 1107 RNRL A T + L T IFD+P LA Y+ ++ G AAA P E Sbjct 4056 RNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAPGE 4104 >gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] gi|148506014|gb|ABQ73823.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] Length=4151 Score = 889 bits (2297), Expect = 0.0, Method: Compositional matrix adjust. Identities = 503/963 (53%), Positives = 638/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQ R+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P+ + F LS Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C AF +ADG EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 608 bits (1569), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|13881781|gb|AAK46387.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] Length=4151 Score = 886 bits (2289), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/963 (53%), Positives = 637/963 (67%), Gaps = 37/963 (3%) Query 27 PNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSAD 86 P + D +DLG S+ + + L G + ++D P+ N L + + + Sbjct 1982 PEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAGL 2041 Query 87 SLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DR 145 H A R T +P+A++G+ CR+PG ++ P+ +WD L + + ++ +P DR Sbjct 2042 PQEIKHTPAVRTTS-----EDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADR 2096 Query 146 GFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWE 194 G+ AG + +GGF+ V FD FF + P EAL MDPQQR+LLE+SWE Sbjct 2097 GWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLELSWE 2156 Query 195 ALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYF 254 ALE AGI P LR S TGVF GV + Y A + + TG SS+ + R++Y Sbjct 2157 ALERAGIDPTGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 255 LDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILS 314 L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V +P + F L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHRGLA 2272 Query 315 QTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAP 374 G C + ADG+ EG G++VLQRLSDAR G +LA++ GSAVNQDG SNG+ AP Sbjct 2273 PDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 375 NPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKR--PGSGPL 432 N +Q V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R PG PL Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE-PL 2391 Query 433 MIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPAIPFTELGLRVVDEL 491 +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+P + ++ + ++ Sbjct 2392 WLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPSPHVDWSAGAVELLTAP 2450 Query 492 QEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISG 551 + WP A R RRAGVSSFG GTNAHVI+E A V R + G +G VV WV+S Sbjct 2451 RVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRREAGWAGP-VVPWVVSA 2502 Query 552 KTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAVVVG RD LLAGL + Sbjct 2503 KSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGLDEL 2561 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 + VV G AGKT FVF GQGSQWLGMG L+A YPVFAEA + VV ELDRHL Sbjct 2562 AGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHL 2621 Query 672 RYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHV 731 PLR+V+WGHD++LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GEL+AAHV Sbjct 2622 LRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHV 2681 Query 732 AGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVI 791 AG L L +AA+LVAARGRLMQALPAGGAM AVQA E+EV P+L +V IAAVNGPAS+VI Sbjct 2682 AGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVI 2741 Query 792 SGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVIS 851 SGA +AV+A+AD+LR GRRVH+LAVSHAFHS LM+PMI EF AVAA +++G PTI VIS Sbjct 2742 SGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS 2801 Query 852 NVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA 911 NVTGQL DDF SA YW RHIR VRF DSVR A AG SRF+EVGP GGL + IE SL Sbjct 2802 NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLP 2861 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 D + ++ LRKDRPEP ++ A AQGFV+GM LDW +V + VELPTYAFQ ++F Sbjct 2862 DVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRF 2919 Query 972 WLA 974 WL+ Sbjct 2920 WLS 2922 Score = 609 bits (1570), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 399/948 (43%), Positives = 547/948 (58%), Gaps = 53/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEA 178 + + + ++ +P DRG+ AG F A +GGF+ VA FD FF I P EA Sbjct 59 MVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C + ADG+ EG G++VLQRLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKR--PGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PN 475 +G+ R PG PL +GS+K N+GH + AAG+AG+IK VL + R LLP+ + P+ Sbjct 354 LATYGQDRGEPGE-PLWLGSVKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDVPS 411 Query 476 PAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 P + ++ + ++ + WP A R RRAGVSSFG GTNAHVI+E A V R Sbjct 412 PHVDWSAGAVELLTAPRVWPAGA-RTRRAGVSSFGISGTNAHVIIE------AVPVVPRR 464 Query 536 DVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAV 595 + G + G VV WV+S K+ SAL QA RL YVR LDV DVG+SL + RSVF+HRAV Sbjct 465 EAGWA-GPVVPWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAV 522 Query 596 VVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPV 655 VVG RD LLAGL + + VV G AGKT FVF GQGSQWLGMG EL P Sbjct 523 VVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPA 582 Query 656 FAEALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVR 714 FA+ +DA + + + L DV+ G L+ + QP LFAV V+L L S V Sbjct 583 FAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVH 642 Query 715 PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV-----QAREDE 769 P V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M ++ QAR D Sbjct 643 PDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQAR-DL 701 Query 770 VAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPM 829 +AP G VSIA VNGP++VV+SG A+ + + R R+ V +A HS +E + Sbjct 702 LAP-FGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAI 760 Query 830 IAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAG 889 + + S VTG + ADYW R++R V F +VR+A G Sbjct 761 RGPLAEALSGIEPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQG 820 Query 890 ASRFIEVGPGGGLTSLIEASLA-----DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 FIE P L + +E + A D++ + VPTL + + +AA FV+G+ Sbjct 821 YRTFIESSPHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVA 880 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 ++W G VELPTYAF ++FWL+ S +D + G +GAS+ Sbjct 881 VNWRGTLDGA--GYVELPTYAFDKRRFWLSAEGSGADVSGLG-LGASE 925 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/89 (47%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A + +V H A VLG +D +AF D GF+SL+AVE+RNRL + Sbjct 1952 RLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSA 2011 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ T++ G Sbjct 2012 TGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 Score = 73.6 bits (179), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 44/111 (40%), Positives = 62/111 (56%), Gaps = 2/111 (1%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 3977 SKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEM 4036 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHG--SSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G ++A AA AE Sbjct 4037 RNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVAAGEAE 4087 >gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Mycobacterium marinum M] gi|183176352|gb|ACC41462.1| polyketide synthase, Pks12 [Mycobacterium marinum M] Length=4187 Score = 882 bits (2278), Expect = 0.0, Method: Compositional matrix adjust. Identities = 503/988 (51%), Positives = 649/988 (66%), Gaps = 52/988 (5%) Query 16 REYLSTHI-ECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSAND 74 R +++T + P + D ++LG S+ + + + G + ++D P+ N Sbjct 1984 RSHIATVLGTITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNG 2043 Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTE 134 L + + + + H A R T ++P+A++G+ CR+PG I+ P+ LWD L Sbjct 2044 LANYIRAELAGAPQEVKHTPAVRVTG-----DDPIAIVGMSCRYPGGIESPDDLWDMLMA 2098 Query 135 KKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEALRMD 182 ++ ++ +P DRG+ AG F +GGF+ V FD FF + P EAL MD Sbjct 2099 RRDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFDPAFFGVGPSEALAMD 2158 Query 183 PQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGG 242 PQQR+ LE+SWEALE AGI P LR S TGVF GV + Y A + + TG Sbjct 2159 PQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQ 2214 Query 243 SSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPE 302 SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG + +P+ Sbjct 2215 LSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPD 2274 Query 303 PWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAV 362 + F LS G C AF +ADG EG G++V++RLSDA+ G +LA++ GSAV Sbjct 2275 IFVEFSRWRGLSADGRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAV 2334 Query 363 NQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVF 422 NQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL + Sbjct 2335 NQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATY 2394 Query 423 GRKRPGSGP----LMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPA 477 G+ R +G L +GSIK N+GH + AAG+AG+IK V + R +LP+ + P+P Sbjct 2395 GQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAM-RHEVLPATLHVDVPSPH 2453 Query 478 IPFTELGLRVVDELQEWPVVAG--RPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 + ++ + ++ E Q WP + R RRAGVSSFG GTNAHVIVE A R Sbjct 2454 VDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAP---------RV 2504 Query 536 DVGGSGGG---VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDH 592 +VGGS GG VV WV+S K+ SAL AQA RL +VR+ LDV DVG+SL + RS F+H Sbjct 2505 EVGGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSL-AGRSTFEH 2563 Query 593 RAVVVGQTRDELLAGLAGVVAGRPEAG--VVCGVGKPAGKTAFVFAGQGSQWLGMGSELY 650 RAVV+G RD LLAGL +AG G V+ GV AGKT FVF GQGSQ LGMG L+ Sbjct 2564 RAVVLGVDRDGLLAGL-DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLH 2622 Query 651 AAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMS 710 A YPVFAEA + VV ELDRHL PLR+VIWGHD++LLNTTEFAQPALFAVEVALYRLL S Sbjct 2623 AGYPVFAEAFNTVVGELDRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLES 2682 Query 711 WGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEV 770 WGVRP V+GHSVGEL+AAHVAG L L +AA+LVAARGRLMQALP GGAM AVQA E EV Sbjct 2683 WGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAVQATEQEV 2742 Query 771 APMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMI 830 P+LG VSIAA+NGPASVVISGA DAVSA+A++LR GRRVHRLAVSHAFHS LM+PMI Sbjct 2743 LPLLGAQVSIAAINGPASVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMI 2802 Query 831 AEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGA 890 EF VA EL+V PTI +ISN+TGQL +DF SA YW RH+R VRF DS+R A AGA Sbjct 2803 DEFATVAGELTVNAPTIGIISNLTGQLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGA 2862 Query 891 SRFIEVGPGGGLTSLIEASLADAQIV----SVPTLRKDRPEPVSVMTAAAQGFVSGMGLD 946 +RF+EVGP GLT+ IE L+DA + + LRKDRPEPVS+++A A FV+G +D Sbjct 2863 ARFLEVGPSSGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSAVAGVFVAGTAVD 2922 Query 947 WASVFSGYRPKRVELPTYAFQHQKFWLA 974 W +V + VELPTYAF+ ++FWL+ Sbjct 2923 WRAVVG--QSNFVELPTYAFERRRFWLS 2948 Score = 594 bits (1532), Expect = 3e-167, Method: Compositional matrix adjust. Identities = 400/964 (42%), Positives = 558/964 (58%), Gaps = 62/964 (6%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGF-----------TNAGTFAESGGFLKDVAGFDNRFFDIPPDEA 178 + E + ++ +P DRG+ T ++A +GGF+ VA FD FF I P EA Sbjct 59 MVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGFVDGVADFDPGFFGIAPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE +GI P LR S TGVF G+ Y ++ + Sbjct 119 LAMDPQHRMLLELSWEALERSGIDPTGLRGSATGVFAGLIVQGYGMFA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G A+ +ADG+ EG ++V++RLSDA+ G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKRPGSG----PLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE- 473 +G+ R +G L +GSIK N+GH + AAG+AG+IK V + R +LP+ + Sbjct 354 LATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAM-RHEVLPATLHVDV 412 Query 474 PNPAIPFTELGLRVVDELQEWPVVAG--RPRRAGVSSFGFGGTNAHVIVEEAGSVGADTV 531 P+P + ++ + ++ E Q WP + R RRAGVSSFG GTNAHVIVE A Sbjct 413 PSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAA-------- 464 Query 532 SGRADVGGSGGG---VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRS 588 R +VGGS GG VV WV+S K+ SAL AQA RL +VR+ LDV DVG+SL + RS Sbjct 465 -PRVEVGGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSL-AGRS 522 Query 589 VFDHRAVVVGQTRDELLAGLAGVVAGRPEAG--VVCGVGKPAGKTAFVFAGQGSQWLGMG 646 F+HRAVV+G RD LLAGL +AG G V+ GV AGKT FVF GQGSQW+GMG Sbjct 523 TFEHRAVVLGVDRDGLLAGL-DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMG 581 Query 647 SELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWG-HDQDLLNTTEFAQPALFAVEVALY 705 EL PVFA +++ + + L DV+ G L+ + QP LFAV V+L Sbjct 582 IELLDTAPVFARHIESCGQAFAEFVDWSLLDVLRGAAGAPGLDRVDVVQPVLFAVMVSLA 641 Query 706 RLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQA 765 L S GVRP V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M +V Sbjct 642 ELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVAC 701 Query 766 REDEVAPML---GHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFH 822 E + +L G VSIAA+NGP++VV+SG A+ + + + R R+ V +A H Sbjct 702 GEQQARELLEPFGDRVSIAAINGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASH 761 Query 823 SALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSV 882 S +E + + T V A + S+VTG + A+YW R+IR V+F +V Sbjct 762 SVEVEAIEGQLTEVLAGIEPLSSRTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAV 821 Query 883 RSAHCAGASRFIEVGPGGGLTSLIE------ASLADAQIVSVPTLRKDRPEPVSVMTAAA 936 RSA G FIE P L + IE A+ + A + VPTL ++ + +AA Sbjct 822 RSACGHGYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA 881 Query 937 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 996 FV+G+ +DW G VELPTYAF+ ++FWL+ D A +G S GG Sbjct 882 AAFVAGVNVDWRGPLDG--AGLVELPTYAFEKRRFWLSGEGVSVD---ASGLGLSAGGHA 936 Query 997 LLAS 1000 LL + Sbjct 937 LLGA 940 Score = 75.9 bits (185), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 39/89 (44%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A +++V H A VLG +D +AF + GF+SL+AVE+RNR+ V Sbjct 1966 RLHGLPEPEQHAVVLDLVRSHIATVLGTITPEAIDPDKAFQELGFDSLTAVEMRNRIKTV 2025 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T ++L T IFD+PTP LA Y+ ++ G Sbjct 2026 TGLSLSPTLIFDYPTPNGLANYIRAELAG 2054 Score = 71.6 bits (174), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 39/96 (41%), Positives = 54/96 (57%), Gaps = 0/96 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A + +V H A VLG +D +AF + GF+SL+AVE+ Sbjct 4012 SKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDAIDPDRAFQELGFDSLTAVEM 4071 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDG 1094 RNRL + T + L T IFD+P LA Y+ ++ G Sbjct 4072 RNRLKSATGLALSPTLIFDYPNSAALAGYMHRELVG 4107 >gi|41407894|ref|NP_960730.1| Pks12 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396248|gb|AAS04113.1| Pks12 [Mycobacterium avium subsp. paratuberculosis K-10] Length=4170 Score = 881 bits (2277), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/991 (51%), Positives = 651/991 (66%), Gaps = 39/991 (3%) Query 11 LQKWFREYLSTHIECHPNE-VSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDN 69 L + R +++T + E + D ++LG S+ + + L G + ++D Sbjct 1976 LLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDY 2035 Query 70 PSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLW 129 P+ N L + + + +H R T ++P+A++G+ CRFPG +D PE LW Sbjct 2036 PTPNALAGYIRTELAGAPQEITHAPVVRATD-----DDPIAIVGMSCRFPGGVDSPEALW 2090 Query 130 DFLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDE 177 + E + ++ +P DRG+ AG + +GGF+ +VA FD FF I P E Sbjct 2091 QMVAEGRDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGIAPSE 2150 Query 178 ALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIW 237 AL MDPQQR+ LE+SWEALE AGI P LR S TG+F GV + Y A + + Sbjct 2151 ALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGY----GMGAAPIAEGF 2206 Query 238 DNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNV 297 TG SSS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 2207 RLTGQSSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATV 2266 Query 298 LISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAIL 357 +P + F L+ G C A+ +ADG EG ++V++RLSDAR G +LA++ Sbjct 2267 NATPTVFVEFSRHRGLAPDGRCKAYAGAADGTGFSEGGAMLVVERLSDARRLGHSVLAVV 2326 Query 358 TGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHA 417 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA A Sbjct 2327 RGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQA 2386 Query 418 LGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSG-GFTEPNP 476 L +G+ R PL +GSIK N+GH + AAG+AG+IK VL + R LLP+ EP+P Sbjct 2387 LLATYGQDR--GQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDEPSP 2443 Query 477 AIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRAD 536 + ++ + ++ E Q WP RPRRAGVSSFG GTNAHVI+E A + A Sbjct 2444 HVDWSAGAVSLLTEAQPWP--GERPRRAGVSSFGISGTNAHVIIE------AVPAAEPAH 2495 Query 537 VGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVV 596 V+ W++S K+A+AL AQA RL YVRA LD+ DVG++L + R+ F+HRAVV Sbjct 2496 ADAPALPVLPWMVSAKSAAALRAQAARLAEYVRAHGELDIADVGWTL-AGRATFEHRAVV 2554 Query 597 VGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVF 656 VG RD LLAGL + P A ++ GV PAGKT FVF GQGSQ LGMG +L+A YPVF Sbjct 2555 VGGDRDRLLAGLDELSTDDPAASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVF 2614 Query 657 AEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPG 716 AEA DAVV ELDRHL PLRDVIWG D+++LN+TEFAQPALFAVEVAL+RLL SWGVRP Sbjct 2615 AEAFDAVVAELDRHLLRPLRDVIWGDDENVLNSTEFAQPALFAVEVALFRLLESWGVRPD 2674 Query 717 LVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPMLGH 776 V+GHS+GEL+AAHVAG L L +AA+LVAARGR MQALP GGAM AVQA E +V P+LG Sbjct 2675 FVMGHSIGELSAAHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLGP 2734 Query 777 DVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAV 836 DV IAAVNGPA+VVISG HDA AIA+RLR +G RVHRL+VSHAFHS LMEPMI EF V Sbjct 2735 DVGIAAVNGPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTV 2794 Query 837 AAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEV 896 AA L+ P IP+ISN+TGQ ADDF S +YW RH+R VRF DSVR A AGA+RF+EV Sbjct 2795 AAGLASDKPVIPIISNLTGQPAADDFGSPEYWKRHVRDAVRFADSVRFAQSAGATRFLEV 2854 Query 897 GPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW-ASVFSGYR 955 GP GLT+ IE +LADA +V+V LRKDRPEPV+++ A AQG+V GM +DW ++ +G+ Sbjct 2855 GPSSGLTAAIEETLADAPVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALGTGH- 2913 Query 956 PKRVELPTYAFQHQKFWLAPAPSVSDPTAAG 986 V+LPTYAF ++FWL+ + SD G Sbjct 2914 --LVDLPTYAFDRRRFWLSGDGAASDAAGLG 2942 Score = 610 bits (1573), Expect = 6e-172, Method: Compositional matrix adjust. Identities = 394/944 (42%), Positives = 550/944 (59%), Gaps = 48/944 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEALWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEA 178 + E + I+ +P DRG+ A + +GGF+ +VA FD FF I P EA Sbjct 59 MVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGFVDNVADFDPAFFGIAPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQQR+ LE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQQRMFLELSWEALERAGIDPVKLRGSATGVFAGLIVQGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C A+ +ADG+ EG ++V++RLSDAR G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHSVLAVVR 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSG-GFTEPNPA 477 +G+ R PL +GSIK N+GH + AAG+AG+IK VL + R LLP+ EP+P Sbjct 354 LATYGQDR--GQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAM-RHELLPATLHVDEPSPH 410 Query 478 IPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADV 537 + ++ + ++ E Q WP RPRRAGVSSFG GTNAHVI+E A + A Sbjct 411 VDWSAGAVSLLTEAQPWP--GERPRRAGVSSFGISGTNAHVIIE------AVPAAEPAHA 462 Query 538 GGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVV 597 V+ W++S K+A+AL AQA RL YVRA LD+ DVG++L + R+ F+HRAVVV Sbjct 463 DAPALPVLPWMVSAKSAAALRAQAARLAEYVRAHGELDIADVGWTL-AGRATFEHRAVVV 521 Query 598 GQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFA 657 G RD LLAGL + P A ++ GV PAGKT FVF GQGSQWLGM +EL PVFA Sbjct 522 GGDRDRLLAGLDELSTDDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFA 581 Query 658 EALDAVVDELDRHLRYPLRDVIWGHDQDL-LNTTEFAQPALFAVEVALYRLLMSWGVRPG 716 + + A + + + L D + G ++ + QPALFAV V+L L S GV P Sbjct 582 QHIQACEEAFAEFVDWSLIDALRGAPGAAGMDRVDVVQPALFAVMVSLAELWKSVGVSPD 641 Query 717 LVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV---QAREDEVAPM 773 V+GHS GE+AAA+VAGAL L DAA +V R +L+++L G M ++ R E+ Sbjct 642 AVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAP 701 Query 774 LGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEF 833 G+ VSIAAVNG +SVV+SG A+ +A R R+ V +A HS +E + + Sbjct 702 YGNRVSIAAVNGRSSVVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDL 761 Query 834 TAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRF 893 + I S VTG + ADYW R+IR V+F +VRSA G F Sbjct 762 AQALTGIEPRSSRIAFFSTVTGNRLDTAGLDADYWYRNIRQTVQFDQAVRSAAEHGYRTF 821 Query 894 IEVGPGGGLTSLIEASL-----ADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWA 948 IE P L + IE ++ D + + +PTL +D +T+AA FV+G+ + W Sbjct 822 IESSPHPALVAGIEDTVNDSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWR 881 Query 949 SVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 V G VELPTYAF ++FWL+ + +D + G +G S+ Sbjct 882 GVLDGA--GFVELPTYAFDRRRFWLSGEGAAADASGLG-LGTSE 922 Score = 79.0 bits (193), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 42/89 (48%), Positives = 55/89 (62%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A +E+V H A VLG A +D +AF + GF+SL+AVE+RNRL Sbjct 1963 RLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTA 2022 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T + L T IFD+PTP LA Y+ T++ G Sbjct 2023 TGLALSPTLIFDYPTPNALAGYIRTELAG 2051 Score = 75.9 bits (185), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 43/109 (40%), Positives = 59/109 (55%), Gaps = 0/109 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V + A VLG + +AF + GF+SL+AVE+ Sbjct 3995 SKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIHPDRAFQELGFDSLTAVEM 4054 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE 1107 RNRL A T + L T IFD+P LA Y+ ++ G AAA P E Sbjct 4055 RNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAPGE 4103 >gi|254822171|ref|ZP_05227172.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=4177 Score = 878 bits (2269), Expect = 0.0, Method: Compositional matrix adjust. Identities = 492/998 (50%), Positives = 640/998 (65%), Gaps = 42/998 (4%) Query 33 DVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESH 92 D ++LG S+ + + L G + ++D P+ N L + + + H Sbjct 2000 DKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNGLAGYIRTELAGAPQEIKH 2059 Query 93 GHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DRGFTNAG 151 R T+ ++P+ ++G+ CR+PG ++ PE LW LTE++ ++ +P DRG+ AG Sbjct 2060 APVARATE-----DDPIVIVGMACRYPGGVNSPEDLWQMLTERRDVLSDFPTDRGWDLAG 2114 Query 152 TF-----------AESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAG 200 + +GGF+ VA FD FF I P EAL MDPQQR+ LE+SWEALE AG Sbjct 2115 VYNPDPDVPGTCYTRTGGFVDGVADFDPAFFGIAPSEALAMDPQQRMFLELSWEALERAG 2174 Query 201 IIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGP 260 I P +LR S TG+F GV + Y A + + TG SSS+ + R+SY L ++GP Sbjct 2175 IEPGALRGSATGMFAGVYTQGY----GIDAAPTAEGFRLTGQSSSVASGRVSYVLGLEGP 2230 Query 261 SIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCH 320 ++ +DTACSSSLVA+H+A +SL + +CD+AL GG V +P+ + F LS G C Sbjct 2231 AVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRCK 2290 Query 321 AFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQI 380 A+ +ADG EG G++V++RLSDA+ G +LA++ GSAVNQDG SNG+ APN +Q Sbjct 2291 AYAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQ 2350 Query 381 GVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPN 440 V+ A +A + E+ VE HGTGT+LGD IEA AL +G+ R GPL +GSIK N Sbjct 2351 RVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGSGGPLWLGSIKSN 2410 Query 441 IGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGR 500 +GH + AAG+AG+IK V + +L + EP+P + ++ + ++ E + W A R Sbjct 2411 MGHTQAAAGVAGVIKMVQAMRHETLPATLHVDEPSPHVDWSAGAVSLLTEARAWS--AER 2468 Query 501 PRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQ 560 PRRAGVSSFG GTNAHVI+E A + V+ R +V V+ WV+S K+ SAL +Q Sbjct 2469 PRRAGVSSFGISGTNAHVIIEAAPAETVQ-VTERPEVP-----VLPWVVSAKSPSALRSQ 2522 Query 561 AGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGV 620 A RL ++RA P LD VDVG++L + RS F+ RAV+V RD LLAGL + A + Sbjct 2523 AARLATHLRAHPDLDAVDVGWTL-AGRSTFEQRAVIVADDRDRLLAGLDELAADELAQSI 2581 Query 621 VCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIW 680 + G P GKT FVF GQGSQ LGMG L+ AYP+FAEA DAV+ ELD+HL PLRDVIW Sbjct 2582 IRGTAAPGGKTVFVFPGQGSQLLGMGRGLHDAYPMFAEAFDAVLAELDQHLLRPLRDVIW 2641 Query 681 GHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDA 740 G D+ LLNTTEFAQPALFAVEVAL+RLL SWG+ P V+GHS+GEL+AAH AG L L +A Sbjct 2642 GSDESLLNTTEFAQPALFAVEVALFRLLESWGIHPDFVMGHSIGELSAAHAAGVLSLKNA 2701 Query 741 AMLVAARGRLMQALPAGGAMFAVQAREDEVAPML----GHDVSIAAVNGPASVVISGAHD 796 A+LVAARGR MQALPAGGAM AVQA EDEV P+L V IAAVNGPASVVISG Sbjct 2702 AVLVAARGRFMQALPAGGAMVAVQATEDEVRPLLVPSEQDSVGIAAVNGPASVVISGTQG 2761 Query 797 AVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQ 856 AV+AIAD+LR +GRRVH+LAVSHAFHS LM+ MI EF VAA L++G PTIP++SNVTG Sbjct 2762 AVTAIADQLRAEGRRVHQLAVSHAFHSPLMDAMIDEFGTVAAGLTIGKPTIPIVSNVTGG 2821 Query 857 LVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIV 916 L DDF +A YW RH+R VRF DSVR H AG +RF+EVGP GLT+ IE +LAD + Sbjct 2822 LATDDFGTAAYWKRHVREAVRFADSVRFVHAAGGNRFLEVGPSSGLTASIEETLADNPVT 2881 Query 917 SVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWL--- 973 ++ LRKDRPEP +++ A A GFV+GM +DW VELPTYAF ++FWL Sbjct 2882 TMSALRKDRPEPTALVNAVAHGFVAGMAVDWRGAIG--TANLVELPTYAFDRRRFWLSRD 2939 Query 974 -APAPSVSDPTAAGQIGASDGGAELLASSGFAARLAGR 1010 APA + A G+ EL AS G L GR Sbjct 2940 DAPADAAGLGLAPGEHALLGAVVELPASGGVV--LTGR 2975 Score = 595 bits (1535), Expect = 2e-167, Method: Compositional matrix adjust. Identities = 390/948 (42%), Positives = 548/948 (58%), Gaps = 51/948 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPESLWQ 58 Query 131 FLTEKKCAITAYP-DRGF-----------TNAGTFAESGGFLKDVAGFDNRFFDIPPDEA 178 + + + I+ +P DRG+ + +GGF+ VA FD FF I P EA Sbjct 59 MVADGRDVISEFPADRGWDLGALYDPDPDARHKCYVNAGGFVDGVADFDPAFFGIAPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPSGLRGSATGVFAGLIVQGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C A+ +ADG+ EG ++V++RLSDA+ G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKAYAGAADGVGWSEGGAILVVERLSDAQRLGHPVLAVVR 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLAASEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAI 478 +G+ R SGPL +GSIK N+GH + AAG+AG+IK V + +L + EP+P + Sbjct 354 LATYGQDRGPSGPLWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHETLPATLHVDEPSPHV 413 Query 479 PFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVG 538 ++ + ++ E Q W A RPRRAGVSSFG GTNAHVI+E A + + V+ R +V Sbjct 414 DWSAGAVSLLTEAQPWG--ADRPRRAGVSSFGISGTNAHVIIEAAPAETVE-VTERPEV- 469 Query 539 GSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVG 598 VV W +S K+A ALAAQA RL Y+RA LDV DVG++L + R+ F+HRAV+V Sbjct 470 ----PVVPWALSAKSARALAAQAARLAEYLRAHHELDVADVGWTL-AGRATFEHRAVIVA 524 Query 599 QTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAE 658 RD LLAGL + P V+ G+ PAGKT FVF GQGSQWLGMG EL PVFA+ Sbjct 525 DDRDRLLAGLDELANDDPTGTVLRGIATPAGKTVFVFPGQGSQWLGMGIELLDTAPVFAQ 584 Query 659 ALDAVVDELDRHLRYPLRDVIWGHD-QDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGL 717 + A + + + L DV+ G ++ + QP LFAV V+L L S GV P Sbjct 585 QIQACEEAFAEFVDWSLIDVLRGAPGAPGMDRVDVVQPVLFAVMVSLAELWKSVGVSPDA 644 Query 718 VLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAV---QAREDEVAPML 774 V+GHS GE+AAA+VAGAL L DA +V R +L+++L G M ++ R E+ Sbjct 645 VIGHSQGEIAAAYVAGALSLRDAVRVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPY 704 Query 775 GHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFT 834 G VSIAAVNG ++VV+SG A+ + R R+ V +A HS +E + + Sbjct 705 GSRVSIAAVNGRSAVVVSGDVAALDELVGFCADLELRTRRIDVDYASHSVEVEAIRDDLA 764 Query 835 AVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFI 894 + + I S VTG + ADYW R+IR V+F +VRSA G FI Sbjct 765 QALSGIEPRSSRIAFFSTVTGNRLDTAGLDADYWYRNIRQTVQFDQAVRSASEHGYRTFI 824 Query 895 EVGPGGGLTSLIE----------ASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMG 944 E P L + IE A ++A++ +PTL +D +T+ A FV+G+ Sbjct 825 ESSPHPALVAGIEDTANHHAGRDAEASEAKV--IPTLGRDDGGLDRFLTSVATAFVAGVS 882 Query 945 LDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASD 992 + W V G VELPTYAF ++FWL+ + +D T G +GAS+ Sbjct 883 VGWRGVLDGA--GFVELPTYAFDRRRFWLSGEGAAADATGLG-LGASE 927 Score = 80.1 bits (196), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 42/89 (48%), Positives = 56/89 (63%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G S EQ A +++V H A VLG A +D +AF + GF+SL+AVE+RNRL Sbjct 1964 RLDGLSEAEQHAVLLDLVRSHIATVLGNTSAEAIDPDKAFQELGFDSLTAVEMRNRLKTA 2023 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T + L T IFD+PTP LA Y+ T++ G Sbjct 2024 TGLALSPTLIFDYPTPNGLAGYIRTELAG 2052 Score = 74.3 bits (181), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 42/109 (39%), Positives = 57/109 (53%), Gaps = 0/109 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V H A VLG + +AF + GF+SL+AVE+ Sbjct 4004 SKSALLQRLEGLPEDEQQAILLDLVRSHIATVLGSSSPEAIHPDRAFQELGFDSLTAVEM 4063 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE 1107 RNRL A T + L T IFD+P LA Y+ ++ G A P E Sbjct 4064 RNRLKAATGLALSPTLIFDYPNSAALAGYMHRELVGASEQTPGGAAPGE 4112 >gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] gi|118569895|gb|ABL04646.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] Length=4191 Score = 877 bits (2267), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/988 (51%), Positives = 648/988 (66%), Gaps = 52/988 (5%) Query 16 REYLSTHI-ECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSAND 74 R +++T + P + D ++LG S+ + + + G + ++D P+ N Sbjct 1988 RSHIATVLGTITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNG 2047 Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTE 134 L + + + + H A R T ++P+A++G+ CR+PG I+ P+ LWD L Sbjct 2048 LANYIRAELAGAPQEVKHTPAVRVTG-----DDPIAIVGMSCRYPGGIESPDDLWDMLMA 2102 Query 135 KKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDEALRMD 182 ++ ++ +P DRG+ AG F +GGF+ V F+ FF + P EAL MD Sbjct 2103 RRDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFEPAFFGVGPSEALAMD 2162 Query 183 PQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGG 242 PQQR+ LE+SWEALE AGI P LR S TGVF GV + Y A + + TG Sbjct 2163 PQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYGMF----AAEPVEGFRLTGQ 2218 Query 243 SSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPE 302 SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG + +P+ Sbjct 2219 LSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPD 2278 Query 303 PWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAV 362 + F LS G C AF +ADG EG G++V++RLSDA+ G +LA++ GSAV Sbjct 2279 IFVEFSRWRGLSADGRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAV 2338 Query 363 NQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVF 422 NQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL + Sbjct 2339 NQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATY 2398 Query 423 GRKRPGSGP----LMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE-PNPA 477 G+ R +G L +GSIK N+GH + AAG+AG+IK V + R +LP+ + P+P Sbjct 2399 GQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAM-RHEVLPATLHVDVPSPH 2457 Query 478 IPFTELGLRVVDELQEWPVVAG--RPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRA 535 + ++ + ++ E Q WP + R RRAGVSSFG GTNAHVIVE A R Sbjct 2458 VDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAP---------RV 2508 Query 536 DVGGSGGG---VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDH 592 +VGGS GG VV WV+S K+ SAL AQA RL +VR+ LDV DVG+SL + RS F+H Sbjct 2509 EVGGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSL-AGRSTFEH 2567 Query 593 RAVVVGQTRDELLAGLAGVVAGRPEAG--VVCGVGKPAGKTAFVFAGQGSQWLGMGSELY 650 RAVV+G RD LLAGL +AG G V+ GV AGKT FVF GQGSQ LGMG L+ Sbjct 2568 RAVVLGADRDGLLAGL-DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLH 2626 Query 651 AAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMS 710 A YPVFAEA + VV ELDRHL PLR+VIWGHD++LLNTTEFAQPALFAVEVALYRLL S Sbjct 2627 AGYPVFAEAFNTVVGELDRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLES 2686 Query 711 WGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEV 770 WGVRP V+GHSVGEL+AAHVAG L L +AA+LVAARGRLMQALP GGAM AVQA E EV Sbjct 2687 WGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAVQATEQEV 2746 Query 771 APMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMI 830 P+LG VSIA +NGPASVVISGA DAVSA+A++LR GRRVHRLAVSHAFHS LM+PMI Sbjct 2747 LPLLGAQVSIATINGPASVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMI 2806 Query 831 AEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGA 890 EF VA EL+V PTI +ISN+TGQL +DF SA YW RH+R VRF DS+R A AGA Sbjct 2807 DEFATVAGELTVNAPTIGIISNLTGQLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGA 2866 Query 891 SRFIEVGPGGGLTSLIEASLADAQIV----SVPTLRKDRPEPVSVMTAAAQGFVSGMGLD 946 +RF+EVGP GLT+ IE L+DA + + LRKDRPEPVS+++A A FV+G +D Sbjct 2867 ARFLEVGPSIGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSALAGVFVAGTAVD 2926 Query 947 WASVFSGYRPKRVELPTYAFQHQKFWLA 974 W +V + VELPTYAF+ ++FWL+ Sbjct 2927 WRAVVG--QSHFVELPTYAFERRRFWLS 2952 Score = 596 bits (1536), Expect = 1e-167, Method: Compositional matrix adjust. Identities = 400/964 (42%), Positives = 559/964 (58%), Gaps = 62/964 (6%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + + ++ +EP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQ 58 Query 131 FLTEKKCAITAYP-DRGF-----------TNAGTFAESGGFLKDVAGFDNRFFDIPPDEA 178 + E + ++ +P DRG+ T ++A +GGF+ VA FD FF I P EA Sbjct 59 MVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGFVDGVADFDPGFFGIAPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE +GI P LR S TGVF G+ Y ++ + Sbjct 119 LAMDPQHRMLLELSWEALERSGIDPTGLRGSATGVFAGLIVQGYGMFA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R++Y L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G A+ +ADG+ EG ++V++RLSDA+ G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + E+ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKRPGSG----PLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTE- 473 +G+ R +G L +GSIK N+GH + AAG+AG+IK V + R +LP+ + Sbjct 354 LATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAM-RHEVLPATLHVDV 412 Query 474 PNPAIPFTELGLRVVDELQEWPVVAG--RPRRAGVSSFGFGGTNAHVIVEEAGSVGADTV 531 P+P + ++ + ++ E Q WP + R RRAGVSSFG GTNAHVIVE A Sbjct 413 PSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAA-------- 464 Query 532 SGRADVGGSGGG---VVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRS 588 R +VGGS GG VV WV+S K+ SAL AQA RL +VR+ LDV DVG+SL + RS Sbjct 465 -PRVEVGGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSL-AGRS 522 Query 589 VFDHRAVVVGQTRDELLAGLAGVVAGRPEAG--VVCGVGKPAGKTAFVFAGQGSQWLGMG 646 F+HRAVV+G RD LLAGL +AG G V+ GV AGKT FVF GQGSQW+GMG Sbjct 523 TFEHRAVVLGADRDGLLAGL-DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMG 581 Query 647 SELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWG-HDQDLLNTTEFAQPALFAVEVALY 705 EL PVFA +++ + + L DV+ G L+ + QP LFAV V+L Sbjct 582 IELLDTAPVFARHIESCGQAFAEFVDWSLLDVLRGAAGAPGLDRIDVVQPVLFAVMVSLA 641 Query 706 RLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQA 765 L S GVRP V+GHS GE+AAA+VAGAL L DAA +V R +L+ L G M +V Sbjct 642 ELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVAC 701 Query 766 REDEVAPML---GHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFH 822 E + +L G VSIAA+NGP++VV+SG A+ + + + R R+ V +A H Sbjct 702 GEQQARELLEPFGDRVSIAAINGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASH 761 Query 823 SALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSV 882 S +E + + T V A + S+VTG + A+YW R+IR V+F +V Sbjct 762 SVEVEAIEGQLTEVLAGIEPLSSRTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAV 821 Query 883 RSAHCAGASRFIEVGPGGGLTSLIE------ASLADAQIVSVPTLRKDRPEPVSVMTAAA 936 RSA G FIE P L + IE A+ + A + VPTL ++ + +AA Sbjct 822 RSACGHGYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA 881 Query 937 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 996 FV+G+ +DW G VELPTYAF+ ++FWL+ D A +G S GG Sbjct 882 AAFVAGVNVDWRGPLDG--AGLVELPTYAFEKRRFWLSGEGVSVD---ASGLGLSAGGHA 936 Query 997 LLAS 1000 LL + Sbjct 937 LLGA 940 Score = 77.0 bits (188), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/96 (43%), Positives = 58/96 (61%), Gaps = 0/96 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S A RL G EQ A +++V H A VLG +D +AF + GF+SL+AVE+ Sbjct 1963 SKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAIDPDKAFQELGFDSLTAVEM 2022 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDG 1094 RNR+ VT ++L T IFD+PTP LA Y+ ++ G Sbjct 2023 RNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELAG 2058 Score = 71.6 bits (174), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 39/96 (41%), Positives = 54/96 (57%), Gaps = 0/96 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A + +V H A VLG +D +AF + GF+SL+AVE+ Sbjct 4016 SKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDAIDPDRAFQELGFDSLTAVEM 4075 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDG 1094 RNRL + T + L T IFD+P LA Y+ ++ G Sbjct 4076 RNRLKSATGLALSPTLIFDYPNSAALAGYMHRELVG 4111 >gi|342859764|ref|ZP_08716417.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342132896|gb|EGT86116.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=4176 Score = 874 bits (2259), Expect = 0.0, Method: Compositional matrix adjust. Identities = 490/962 (51%), Positives = 631/962 (66%), Gaps = 42/962 (4%) Query 33 DVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESH 92 D ++LG S+ + + L G + ++D P+ N L + Q + H Sbjct 2002 DKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNGLAGYIRTQLAGVPQEIKH 2061 Query 93 GHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DRGFTNAG 151 R T ++P+ ++G+ CR+PG + P+ LWD LTE + ++ +P DRG+ AG Sbjct 2062 APVARATG-----DDPIVIVGMACRYPGGVSSPDDLWDMLTEGRDVLSEFPTDRGWDLAG 2116 Query 152 TF-----------AESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAG 200 + +GGF+ VA FD FF I P EAL MDPQQR+ LE+SWEALE AG Sbjct 2117 VYNPDPDVPGTCYTRTGGFVDGVADFDPAFFGIAPSEALSMDPQQRMFLELSWEALERAG 2176 Query 201 IIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGP 260 I P LR S TG+F GV + Y + +A+ + TG SSS+ + R+SY L ++GP Sbjct 2177 IDPGKLRGSATGMFAGVYTQGYGMGAAPTAEG----FRLTGQSSSVASGRVSYVLGLEGP 2232 Query 261 SIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCH 320 ++ +DTACSSSLVA+H+A +SL + +CD+AL GG V +P+ + F LS+ G C Sbjct 2233 AVSVDTACSSSLVALHMAAQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSEDGRCK 2292 Query 321 AFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQI 380 A+ +ADG EG G++V++RLSDA+ G +LA++ GSA+NQDG SNG+ APN +Q Sbjct 2293 AYAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLAMVRGSAINQDGASNGLTAPNGPSQQ 2352 Query 381 GVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPN 440 V+ A +A + P E+ VE HGTGT+LGD IEA AL +G+ R PL +GSIK N Sbjct 2353 RVVRAALANAGLTPAEVDVVEGHGTGTTLGDPIEAQALLATYGQDR--GEPLWLGSIKSN 2410 Query 441 IGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEW-PVVAG 499 +GH + AAG+AG+IK VL + L + EP+P + ++ + ++ + ++W P Sbjct 2411 MGHTQAAAGVAGVIKMVLAMRHEILPATLHVDEPSPHVDWSTGSVSLLTQARDWKPKPDD 2470 Query 500 RPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAA 559 RPRRAGVSSFG GTNAHVI+E A G V V G VV W +S K+ SAL + Sbjct 2471 RPRRAGVSSFGISGTNAHVIIE-AVPAGQPRV-----VDGPAAPVVPWPVSAKSLSALTS 2524 Query 560 QAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAG 619 QA RL ++RA P LD+ DVG+SL + RS F+ RAVVVG RD LLAGL + Sbjct 2525 QATRLAAHLRAHPDLDIADVGWSL-AGRSAFEQRAVVVGGDRDGLLAGLEELAGDNLGGS 2583 Query 620 VVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVI 679 ++ G AGKTAFVF GQGSQ LGMG L+A YPVFAEA D VV ELD+HL PLR+V+ Sbjct 2584 IIQGTAT-AGKTAFVFPGQGSQTLGMGRGLHAGYPVFAEAFDTVVAELDQHLLRPLREVM 2642 Query 680 WGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPD 739 WG D+ LLN+TEFAQPALFAVEVAL+RLL SWGVRP V+GHS+GELAAAHVAG L L + Sbjct 2643 WGDDETLLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELAAAHVAGVLSLQN 2702 Query 740 AAMLVAARGRLMQALPAGGAMFAVQAREDEV-APMLGHD---VSIAAVNGPASVVISGAH 795 AA+LVAARGR MQALP GGAM AVQA EDEV A ++G D V IAAVNGP SVVISGAH Sbjct 2703 AAVLVAARGRFMQALPEGGAMVAVQATEDEVRALLVGSDQASVGIAAVNGPTSVVISGAH 2762 Query 796 DAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTG 855 +AV+A+ADRLR G RVHRL+VSHAFHS LM+PMI EF VAA L+VG P IP++SNVTG Sbjct 2763 EAVAAVADRLRADGHRVHRLSVSHAFHSPLMDPMIDEFGTVAAGLTVGKPAIPIVSNVTG 2822 Query 856 QLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLA---- 911 QL DD+AS YW RH+R VRF DSVR H AGA+RF+EVGPG GLT+ IE SLA Sbjct 2823 QLAGDDYASVAYWKRHVREAVRFADSVRFVHSAGANRFLEVGPGSGLTASIEESLAADPM 2882 Query 912 DAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKF 971 A + ++ LRKDRPEP+S++ A AQG+V+GM +DW VELPTYAF ++F Sbjct 2883 AASVTTMSALRKDRPEPLSLVNAVAQGYVAGMDVDWRGALG--EGNLVELPTYAFDRRRF 2940 Query 972 WL 973 WL Sbjct 2941 WL 2942 Score = 596 bits (1536), Expect = 1e-167, Method: Compositional matrix adjust. Identities = 386/928 (42%), Positives = 533/928 (58%), Gaps = 49/928 (5%) Query 75 LIDSLLNQRSADSLRESHGHADRNTQGRGSI----NEPVAVIGVGCRFPGDIDGPERLWD 130 ++D L Q + ++LR++ +R + ++ NEP+A++G+ CRFPG +D PE LW Sbjct 1 MVDQL--QHATEALRKALVQVERLKRTNRALLERSNEPIAIVGMSCRFPGGVDSPEALWQ 58 Query 131 FLTEKKCAITAYP-DRGFTNAG-----------TFAESGGFLKDVAGFDNRFFDIPPDEA 178 + + + I+ +P DRG+ A + +GGF+ VA FD FF I P EA Sbjct 59 MVADGRDVISEFPADRGWDVASLYDPDPDARHKCYVNTGGFVDGVADFDPAFFGIAPSEA 118 Query 179 LRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD 238 L MDPQ R+LLE+SWEALE AGI P LR S TGVF G+ Y L ++ + Sbjct 119 LAMDPQHRMLLELSWEALERAGIDPSGLRGSATGVFAGLIVQGYGMLA-----EEIEGYR 173 Query 239 NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVL 298 TG +SS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 174 LTGMTSSVASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVN 233 Query 299 ISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILT 358 +P + F L+ G C A+ +ADG+ EG ++V++RLSDA+ G +LA++ Sbjct 234 ATPTVFVEFSRHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLAVVR 293 Query 359 GSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHAL 418 GSAVNQDG SNG+ APN +Q V+ A +A + ++ VE HGTGT+LGD IEA AL Sbjct 294 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSVADVDVVEGHGTGTTLGDPIEAQAL 353 Query 419 GMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAI 478 +G+ R S PL +GSIK N+GH + AAG+AG+IK V + +L + P+P + Sbjct 354 LATYGQDR--SEPLWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHETLPATLHVDAPSPHV 411 Query 479 PFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVG 538 ++ + ++ E + W V RPRRAGVSSFG GTNAHVIVE A + Sbjct 412 DWSAGAVSLLTEARPWNVE--RPRRAGVSSFGISGTNAHVIVEAAPAQPEREA------- 462 Query 539 GSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVG 598 G VV W +S K+ SALAAQA RL YVRA LDV D+G+SL + R+ F+HRAVV+G Sbjct 463 GPARPVVPWAVSAKSPSALAAQAARLAEYVRAHRDLDVADIGWSL-AGRAAFEHRAVVIG 521 Query 599 QTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAE 658 RD LLAGL + P V+ GV P+GKT FVF GQGSQW GM EL A PVFA+ Sbjct 522 ADRDRLLAGLDELANDDPTGSVIRGVATPSGKTVFVFPGQGSQWAGMAVELLDAAPVFAQ 581 Query 659 ALDAVVDELDRHLRYPLRDVIWGH-DQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGL 717 + + + + L V+ G D L+ + QP LFAV V+L L S GV P Sbjct 582 QIRECEEAFAEFVDWSLTGVLRGAPDAPGLDRVDVVQPVLFAVMVSLAELWKSVGVNPDA 641 Query 718 VLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQA---REDEVAPML 774 V+GHS GE+AAA+VAGAL L DAA +V R +L+ AL G M ++ R E+ Sbjct 642 VIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLTALAGPGGMLSIACSTERARELLAPY 701 Query 775 GHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFT 834 G+ VSIAAVNG ++VV+SG A+ + R R+ V +A HS +E + A+ Sbjct 702 GNRVSIAAVNGRSAVVVSGEGAALDELVGFCADLELRTRRIDVDYASHSVEVEAIRADLA 761 Query 835 AVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFI 894 V + + I S VTG + ADYW R+IR V+F +VRSA G FI Sbjct 762 EVLSGIEPRSSRIAFFSTVTGSRLDTAGLDADYWYRNIRQTVQFDQAVRSACEHGYRTFI 821 Query 895 EVGPGGGLTSLIEASLAD--------AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLD 946 E P L + IE + D A++ +PTL +D +T+AA FV+G+ + Sbjct 822 ESSPHPALIAGIEDTADDHVGGGADGAEVTVIPTLGRDDGGLDRFLTSAAAAFVAGVSVR 881 Query 947 WASVFSGYRPKRVELPTYAFQHQKFWLA 974 W G VELPTYAF ++FWL+ Sbjct 882 WRGALDGA--AFVELPTYAFDRRRFWLS 907 Score = 80.9 bits (198), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 43/89 (49%), Positives = 56/89 (63%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G S EQ A +++V H A VLG A +D +AF + GF+SL+AVE+RNRL Sbjct 1966 RLDGLSEAEQHAVLLDLVRSHIATVLGNTTAEAIDPDKAFQELGFDSLTAVEMRNRLKTA 2025 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T + L T IFD+PTP LA Y+ TQ+ G Sbjct 2026 TGLALSPTLIFDYPTPNGLAGYIRTQLAG 2054 Score = 68.6 bits (166), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 38/96 (40%), Positives = 54/96 (57%), Gaps = 0/96 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V + A VLG + +AF + GF+SL+AVE+ Sbjct 4004 SKSALLQRLEGLPEDEQQAILLDLVRANIATVLGSASPEAIHPDRAFQELGFDSLTAVEM 4063 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDG 1094 RNRL A T + L T IFD+P LA Y+ ++ G Sbjct 4064 RNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVG 4099 >gi|296165135|ref|ZP_06847686.1| possible erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295899547|gb|EFG79002.1| possible erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] Length=2440 Score = 872 bits (2253), Expect = 0.0, Method: Compositional matrix adjust. Identities = 499/979 (51%), Positives = 643/979 (66%), Gaps = 38/979 (3%) Query 11 LQKWFREYLSTHI-ECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDN 69 L R +++T + P V D +DLG S+ + + L G + ++D Sbjct 247 LLDLVRSHIATVLGNTTPEAVDPDKAFQDLGFDSLTAVEMRNRLKTATGLALSPTLIFDY 306 Query 70 PSANDLIDSLLNQRSADSLRESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLW 129 P+ N L + + + + R ++P+ ++G+ CR+PG +D P+ LW Sbjct 307 PTPNGLAGYIRGELAGVPQEVAPAPVARAVG-----DDPIVIVGMSCRYPGGVDSPDDLW 361 Query 130 DFLTEKKCAITAYP-DRGFTNAGTF-----------AESGGFLKDVAGFDNRFFDIPPDE 177 L E++ ++ +P DRG+ AG + +GGF+ VA FD FF I P E Sbjct 362 QMLVERRDVLSEFPTDRGWDLAGIYNPDPDVPGTCYTRTGGFVDGVADFDPAFFGIAPSE 421 Query 178 ALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIW 237 AL MDPQQR+ LE+SWEALE AGI P +LR S TGVF GV + Y + +A+ + Sbjct 422 ALSMDPQQRMFLELSWEALERAGIEPGALRGSATGVFAGVYTQGYGMGAAPAAEG----F 477 Query 238 DNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNV 297 TG SSS+ + R+SY L ++GP++ +DTACSSSLVA+H+A +SL + +CD+AL GG V Sbjct 478 RLTGQSSSVASGRVSYALGLEGPAVSVDTACSSSLVALHMAAQSLRSGECDLALAGGVTV 537 Query 298 LISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAIL 357 +P+ + F LS G C A+ +ADG EG G++V++RLSDA+ G +LA++ Sbjct 538 NATPDIFVEFSRMRGLSADGRCKAYAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLAVV 597 Query 358 TGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHA 417 GSA+NQDG SNG+ APN +Q V+ A +A + ++ VE HGTGT+LGD IEA A Sbjct 598 RGSAINQDGASNGLTAPNGPSQQRVVRAALANAGLAAADVDAVEGHGTGTTLGDPIEAQA 657 Query 418 LGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPA 477 L +G+ R + PL++GSIK N+GH + AAG+AG+IK VL + +L + EP+P Sbjct 658 LLATYGQDR--TEPLLLGSIKSNMGHTQAAAGVAGVIKMVLAMRHATLPATLHVDEPSPH 715 Query 478 IPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADV 537 + ++ + ++ E + W RPRRAGVSSFG GTNAHVI+E A + A R + Sbjct 716 VDWSVGSVALLTEPRPWQ--PNRPRRAGVSSFGISGTNAHVIIESAPAQPAPAPE-RTKL 772 Query 538 GGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTRSVFDHRAVVV 597 V+ WV+S K+ SAL++QA RL ++R R LD DV +SL + RS FDHRAVVV Sbjct 773 P-----VIPWVVSAKSLSALSSQAHRLAGHLRRRDELDGADVAWSL-AGRSHFDHRAVVV 826 Query 598 GQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFA 657 G RD+LLAGL + G VV G GKT FVF GQG+Q LGMG L+AAYP FA Sbjct 827 GADRDQLLAGLDELATGG-AGSVVQGTAVSGGKTVFVFPGQGAQILGMGMGLHAAYPAFA 885 Query 658 EALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRLLMSWGVRPGL 717 A D VV ELDRHL PLR+V+WGHD+ LLNTTEFAQPALFAVEVAL+RLL SWG+ P L Sbjct 886 VAFDTVVAELDRHLLRPLREVMWGHDESLLNTTEFAQPALFAVEVALFRLLESWGIHPDL 945 Query 718 VLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPML--G 775 VLGHS+GEL+AAHVAG L L +AA+LVAARGR MQALP GGAMFAVQA E+EV P+L Sbjct 946 VLGHSIGELSAAHVAGVLSLENAAVLVAARGRFMQALPEGGAMFAVQATEEEVRPLLERS 1005 Query 776 HDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAEFTA 835 V IAAVNGPASVVISGA D VSAIADRLR GRRVHRLAVSHAFHS LM+PMI EF Sbjct 1006 EQVGIAAVNGPASVVISGAEDEVSAIADRLRADGRRVHRLAVSHAFHSPLMDPMIDEFGT 1065 Query 836 VAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHCAGASRFIE 895 VAA L++G PTIP++SN+TGQ DDFAS YW RHIR VRF DSVR AH AGA+RF+E Sbjct 1066 VAAGLALGKPTIPIVSNLTGQPAGDDFASPAYWKRHIREAVRFADSVRFAHSAGATRFLE 1125 Query 896 VGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASVFSGYR 955 VGP GGLT+ IE SLADA IV++ LRKDRPEPV ++ A AQGFV+GM +DW + Sbjct 1126 VGPSGGLTASIEESLADAPIVTMSALRKDRPEPVILVNAVAQGFVAGMDVDWRRAIG--Q 1183 Query 956 PKRVELPTYAFQHQKFWLA 974 VELPTYAF+ ++FWLA Sbjct 1184 ANFVELPTYAFERRRFWLA 1202 Score = 75.1 bits (183), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 42/109 (39%), Positives = 60/109 (56%), Gaps = 0/109 (0%) Query 999 ASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVEL 1058 + S RL G DEQ A +++V + A VLG +D +AF + GF+SL+AVE+ Sbjct 2263 SKSALLQRLEGLPEDEQQAVLLDLVRANIATVLGNSSPESIDPDRAFQELGFDSLTAVEM 2322 Query 1059 RNRLTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAAANPAE 1107 RNRL + T + L T IFD+P LA Y+ ++ G + AA P E Sbjct 2323 RNRLKSATGLALSPTLIFDYPNSAALAGYMHRELVGAAEQQSPAAAPGE 2371 Score = 75.1 bits (183), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 40/89 (45%), Positives = 53/89 (60%), Gaps = 0/89 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G EQ A +++V H A VLG +D +AF D GF+SL+AVE+RNRL Sbjct 234 RLHGLPETEQHAVLLDLVRSHIATVLGNTTPEAVDPDKAFQDLGFDSLTAVEMRNRLKTA 293 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQIDG 1094 T + L T IFD+PTP LA Y+ ++ G Sbjct 294 TGLALSPTLIFDYPTPNGLAGYIRGELAG 322 >gi|15826966|ref|NP_301229.1| polyketide synthase [Mycobacterium leprae TN] gi|221229444|ref|YP_002502860.1| putative polyketide synthase [Mycobacterium leprae Br4923] gi|13092513|emb|CAC29643.1| putative polyketide synthase [Mycobacterium leprae] gi|219932551|emb|CAR70228.1| putative polyketide synthase [Mycobacterium leprae Br4923] Length=2103 Score = 866 bits (2238), Expect = 0.0, Method: Compositional matrix adjust. Identities = 468/882 (54%), Positives = 593/882 (68%), Gaps = 21/882 (2%) Query 106 NEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DRGFTNAG-----------TF 153 EPVAV+G+GCRFPG +D P+RLWD ++E + ++ +P DRG+ G T+ Sbjct 41 TEPVAVVGIGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY 100 Query 154 AESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGV 213 G FL D AGFD FF I P E L MDPQQRL+LEVSWEALE+AGI P SLR S TGV Sbjct 101 TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGV 160 Query 214 FVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLV 273 F G+ + Y + Q + TG + S+ + R+SY L ++GP++ +DTACSSSLV Sbjct 161 FTGIFAPSYGSRDTGGLQG----YGLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLV 216 Query 274 AVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGE 333 A+H A SL + +CD+AL GG V+ P + GF L+ G C AF ++ADG GE Sbjct 217 AIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFARAADGTGWGE 276 Query 334 GCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACKSARVD 393 G GV+VL+RLSDA+ G +LA++ GSAVNQDG SNG+ APN AQ V++ A +A + Sbjct 277 GAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLS 336 Query 394 PLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGL 453 ++ VEAHGT T+LGD IEA AL +G+ RP PL +GSIK N+GH + AAG+AG+ Sbjct 337 SADVDVVEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAGVAGV 396 Query 454 IKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGG 513 IK V + + + EP+P + +T + V+ E ++W V GRPRRAGVSSFG G Sbjct 397 IKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSV-EGRPRRAGVSSFGISG 455 Query 514 TNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPA 573 TNAHVI+EEA + + S S VV WV+SG++ +AL AQA RL YV+A P Sbjct 456 TNAHVILEEAPTPVEASYSTADQQRLS---VVPWVVSGRSTAALMAQASRLAFYVQADPE 512 Query 574 LDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAF 633 +D VDVG +L + RSVF+HRAVVVG++R++L+AGLAG+ G AGV G P GKT Sbjct 513 VDPVDVGCAL-AARSVFEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVV 571 Query 634 VFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFA 693 VF GQG+Q +GMG EL + PVFAE DAV ELDRH+R PLRDV+WG D LL++TEFA Sbjct 572 VFPGQGAQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADAGLLDSTEFA 631 Query 694 QPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQA 753 QPALFAVEVAL+ +L WG++P V+GHS+GELAAA+VAG L DAAMLV ARGRLMQ+ Sbjct 632 QPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAAMLVVARGRLMQS 691 Query 754 LPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVH 813 +PAGG M+AV A EDEV +LG V IAA+N P SVVISG AVSAIAD+ QGRRVH Sbjct 692 MPAGGTMWAVAASEDEVVSLLGEGVGIAAINAPESVVISGPQAAVSAIADKFAAQGRRVH 751 Query 814 RLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIR 873 +LAVSHAFHS LMEPM+ EF VAA++ V P I ++SNVTG+L DF S YW H+ Sbjct 752 QLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPDFGSPQYWGEHVS 811 Query 874 AVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMT 933 VRF DS R GA+ FIE GP GL IE SLA A+ V V + KDRPE SV+ Sbjct 812 RAVRFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAVVVSMMGKDRPELASVLG 871 Query 934 AAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAP 975 AA Q F +GM ++W +VF+G +RV LPTYAFQ ++FW P Sbjct 872 AAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETP 913 Score = 94.7 bits (234), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 47/87 (55%), Positives = 59/87 (68%), Gaps = 0/87 (0%) Query 1006 RLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLTAV 1065 RL G +A+ QL + VVC AAAVLGR +D F D GF+SL+AVELRNRL + Sbjct 1990 RLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSA 2049 Query 1066 TAVTLPATAIFDHPTPTELAQYLITQI 1092 T +TLP T IFDHPTPT +A+Y+ Q+ Sbjct 2050 TGLTLPPTVIFDHPTPTAVAEYVAQQM 2076 >gi|336457823|gb|EGO36817.1| polyketide synthase family protein [Mycobacterium avium subsp. paratuberculosis S397] Length=1095 Score = 861 bits (2225), Expect = 0.0, Method: Compositional matrix adjust. Identities = 493/1008 (49%), Positives = 631/1008 (63%), Gaps = 25/1008 (2%) Query 97 RNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYP-DRGFTNAG---- 151 R + G ++EPVAV+G+ CR+ G +D PE LWD + E + ++ +P DRG+ G Sbjct 24 RVAELEGRLSEPVAVVGMACRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDP 83 Query 152 -------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPE 204 + G FL+ FD FF I P EAL MDPQQR++LE+ WEALE AGI P Sbjct 84 DPDAKGKMYTRQGSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPS 143 Query 205 SLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVI 264 +LR + TGVF GV Y V + + TG + S+ + R+SY L ++GP++ + Sbjct 144 ALRGTATGVFAGVIHAGYGGEVKGELEG----YGLTGSTLSVTSGRVSYVLGLEGPAVSV 199 Query 265 DTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDK 324 DTACSSSLVA+HLA +SL + +CD+AL GG V+ +P + F L+ G C + Sbjct 200 DTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALAPDGRCKVYAG 259 Query 325 SADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLE 384 +ADG EG GV+VL+RL DAR G + A+L GSAVNQDG SNG+ APN +Q V+ Sbjct 260 AADGTSWSEGAGVLVLERLGDARRLGHPVWAVLRGSAVNQDGASNGLTAPNGPSQQRVIR 319 Query 385 NACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHL 444 A +A + +++ VE HGTGT LGD IEA AL +G+ RP PL +GSIK NIGH Sbjct 320 AALANAGLSAVDVDVVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHT 379 Query 445 EGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRA 504 AAG+AG+IK V + G + + P+P + ++ + ++ + + WP G PRRA Sbjct 380 SAAAGVAGVIKMVQAIRHGVMPKTLHVDVPSPHVDWSAGAVSLLTDPRPWPEHGG-PRRA 438 Query 505 GVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRL 564 GVSSFG GTNAHVIVE+A + + + VV WV+S ++A ALA QA RL Sbjct 439 GVSSFGISGTNAHVIVEQAPAAAETEAAPASSA--MPDAVVPWVVSARSAEALAGQARRL 496 Query 565 GRYVRARPALDVVDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGV 624 +V A +DVG+SLVSTR+VF+HRAVVVG R L GLAG+ +GRP+A V G Sbjct 497 LDHVTADAQASPLDVGWSLVSTRAVFEHRAVVVGCERGALATGLAGLASGRPDAATVVGR 556 Query 625 GKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQ 684 + GKT VF GQGSQ LGMG +LY + VFA ALD V +D H R P+R+V+WG D Sbjct 557 ARATGKTVLVFPGQGSQTLGMGRQLYERFVVFARALDEAVAVVDEHSRLPVREVMWGADP 616 Query 685 DLLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLV 744 +LL +TEFAQPALF EVAL L S GV P +V+GHSVGE+AAA VAG L LPDAA LV Sbjct 617 ELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLPDAARLV 676 Query 745 AARGRLMQALPAGGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADR 804 AARG LM ALPAGG M AV A E +VAP++G VSIAAVNGP +VV+SG +AV+A+A+R Sbjct 677 AARGALMAALPAGGVMVAVTAGEAQVAPLVGGGVSIAAVNGPDAVVLSGEQEAVAAVAER 736 Query 805 LRGQGRRVHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFAS 864 L G G RVHRLAVSHAFHSALMEPM+ F A AA + P IP++SN+TGQL + + Sbjct 737 LAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGT 796 Query 865 ADYWARHIRAVVRFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKD 924 YW H+R V+F VR+A AGA F+E+GPG LT+ ++ SL+ ++ TL KD Sbjct 797 PQYWVEHVRRPVQFLAGVRAAEQAGAGTFLELGPGAALTAAVDQSLSTEGATAIATLPKD 856 Query 925 RPEPVSVMTAAAQGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTA 984 RPE S + AA F G LDWA VF+G +RVELPTYAF ++FWL A P Sbjct 857 RPETESALHAAGHLFTRGHRLDWAGVFAGLPARRVELPTYAFARERFWLGGASLAGAPAG 916 Query 985 AGQIGASDGGAELLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQA 1044 A +G EL A RL DEQ E+VCEHAAAVLG +D +A Sbjct 917 AAPVGGGTRAPEL------AHRLHALPRDEQQRVLRELVCEHAAAVLGHPDGDAIDPHRA 970 Query 1045 FADSGFNSLSAVELRNRLTAVTAVTLPATAIFDHPTPTELAQYLITQI 1092 FAD GF+SL VELRNRLT T L T IFD+PTPT LA +L Q+ Sbjct 971 FADLGFDSLIGVELRNRLTTHTGTALSRTLIFDYPTPTALADHLRRQL 1018 >gi|302540056|ref|ZP_07292398.1| modular polyketide synthase [Streptomyces hygroscopicus ATCC 53653] gi|302457674|gb|EFL20767.1| modular polyketide synthase [Streptomyces himastatinicus ATCC 53653] Length=2907 Score = 860 bits (2222), Expect = 0.0, Method: Compositional matrix adjust. Identities = 568/1441 (40%), Positives = 792/1441 (55%), Gaps = 131/1441 (9%) Query 36 IRDLGLKSIDVLAIPGDLGDRFGFCIPDLAVWDNPSANDLIDSLLNQRSADS-------L 88 +DLG S+ + + L + +P V+D+P+ + L L Q ++ L Sbjct 1513 FKDLGFDSLTAVDLRNRLTNATALPLPATLVFDHPTPSALAGFLREQVVGETPGPDITPL 1572 Query 89 RESHGHADRNTQGRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPD-RGF 147 ++ HA +T+ +P+A++G+GCRFPG + PE LWD + ++ +PD RG+ Sbjct 1573 PQAPVHAAGDTE------DPIAIVGMGCRFPGGVSSPEALWDLVASAGDGLSPFPDDRGW 1626 Query 148 ----------TNAGT-FAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLLLEVSWEAL 196 +AGT + GGF++D AGFD F I P EAL MDPQQRLLLE SWEAL Sbjct 1627 DLDGLYDPDPAHAGTSYVRVGGFVQDAAGFDAELFGISPREALAMDPQQRLLLETSWEAL 1686 Query 197 EHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWDNTGGSSSIIANRISYFLD 256 E AG+ P SLR S TGVF G + DY+ + + TG ++S+I+ RISY L Sbjct 1687 ERAGVDPLSLRGSATGVFAGTNGQDYLHTLGGRVDGVEG-FVGTGSAASVISGRISYALG 1745 Query 257 IQGPSIVIDTACSSSLVAVHLACRSLSTWDCDIALVGGTNVLISPEPWGGFREAGILSQT 316 ++GP++ +DTACSS+LVA+HLA +SL + +C +AL GG V+ +P + F + L+ Sbjct 1746 LEGPAVTVDTACSSALVALHLASQSLRSGECRMALAGGATVMSTPAAFVEFSQQRGLAPD 1805 Query 317 GCCHAFDKSADGMVRGEGCGVIVLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNP 376 G C AF + ADG EG GV+VL+RLSDA+ G R+LA++ GSAVNQDG SNG+ APN Sbjct 1806 GRCKAFAEGADGTGWSEGAGVLVLERLSDAQRLGHRVLAVVRGSAVNQDGASNGLTAPNG 1865 Query 377 SAQIGVLENACKSARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGS 436 +Q V+ A ++A+V ++ VEAHGTGTSLGD IEA AL +GR R G PL +GS Sbjct 1866 PSQQRVIRQALRAAKVSASDVDAVEAHGTGTSLGDPIEAQALLATYGRDREGD-PLWLGS 1924 Query 437 IKPNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVVDELQEWPV 496 +K NIGH + AAG AGLIK V+ + L P+ P+ + ++ +R++ + + WP Sbjct 1925 VKSNIGHTQAAAGAAGLIKMVMALCAQQLPPTLHVDSPSSHVDWSSGAVRLLTDARAWP- 1983 Query 497 VAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADTVSGRADVGGSGGGVVAWVISGKTASA 556 R RRAGVSSFG GTNAHVI+EEA T R VV WV+SG+++ Sbjct 1984 KGERTRRAGVSSFGISGTNAHVILEEAPQTAPVTAEERPSAELP---VVPWVLSGRSSQT 2040 Query 557 LAAQAGRLGRYVRARPALDV-----VDVGYSLVSTRSVFDHRAVVVGQTRDELLAGLAGV 611 L AQAGRL ++ AR DV +DVG+SL +TR++ DHRAVV+G L G+ + Sbjct 2041 LRAQAGRLASFLDARSGTDVHDNSRLDVGFSLATTRALLDHRAVVLGADDAALRTGVTAL 2100 Query 612 VAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL 671 G EA VV GV G+TA++F GQGSQ +GMG ELY +PVFA LD V LD L Sbjct 2101 AGG--EASVVSGV-VSEGRTAWMFTGQGSQRIGMGRELYDRFPVFARTLDEVCAHLDAEL 2157 Query 672 ------RYPLRDVIWGHDQD----LLNTTEFAQPALFAVEVALYRLLMSWGVRPGLVLGH 721 +R ++ D LL+ T +AQ ALFAV+ AL LL S G+ P +VLGH Sbjct 2158 DGAAGFDITVRQALFAPDGSDEAALLDRTGYAQTALFAVQTALVELLRSCGMSPDVVLGH 2217 Query 722 SVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAREDEVAPML------- 774 S+GEL AA AG L DA+ LVAAR RLMQALP GGAM A++A EDEV +L Sbjct 2218 SIGELVAARTAGVFDLADASRLVAARARLMQALPTGGAMAAIEAGEDEVVRILDEAAKAA 2277 Query 775 --GHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALMEPMIAE 832 G +IAAVNGP++VVISG DAV R + RRV RL VSHAFHS LM P++A+ Sbjct 2278 PEGGRAAIAAVNGPSAVVISGDEDAVERAMAVARAEDRRVSRLRVSHAFHSPLMRPVLAD 2337 Query 833 FTAVAAELSVGLPTIPVISNVTGQLVAD-DFASADYWARHIRAVVRFGDSVRSAHCA-GA 890 F +A ++ P +P +S VTG V + D+A+ DYW R IR VRF D+VR+A GA Sbjct 2338 FARIAESVTYRQPVLPAVSTVTGGPVGERDWATGDYWVRQIRRPVRFHDAVRTATGELGA 2397 Query 891 SRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWASV 950 +R +EVGP LTSL+ +DA+ +V LR+DR E S++TAAA+ FV G +DWA++ Sbjct 2398 TRLLEVGPDPVLTSLVP---SDAE-TAVSVLRRDRGEIESLLTAAAEMFVRGTDVDWAAL 2453 Query 951 FSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTA-AGQIGASD--------GGAELLASS 1001 F+G R+ELPTYAF+ ++FWLA + T + GA D G + Sbjct 2454 FAGTGALRIELPTYAFRRRRFWLADRAAEPGTTPLLSRWGAGDHERSSALPGAERVEDHR 2513 Query 1002 GFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNR 1061 AARL G +A+EQ + ++ A+VLG ++ G+ F + GF SLS +LR R Sbjct 2514 EVAARLRGMTAEEQDRTLLGLITSQIASVLGHTDVTEVEIGRRFLEMGFTSLSITDLRTR 2573 Query 1062 LTAVTAVTLPATAIFDHPTPTELAQYLITQIDGHGSSAAAA--------------ANPAE 1107 L+ T + L A A+F+H TP LA +L+ +DG AA A A Sbjct 2574 LSRATGLALTAEALFEHATPRALATHLLAGLDGSAGPAATAGPERADGMAAGPERAGGTA 2633 Query 1108 RIDALTDLFLQACDAGRDADGWKMVALASNTRERM------------SSPVRNNVSKNVA 1155 R +T LF A D + G ++ LA+ TR R + PVR Sbjct 2634 RSGTVTHLFRHAFDQEQHERGLDLLDLAAGTRPRFQVHDTGGEGPTGAEPVR-------- 2685 Query 1156 LLADGISDVVVICIPTLTVLSDQREYRDIANAMTGRHSVYSLTLPGFDSSDALPQNADMI 1215 L+DG ++C+P+L + ++ A A+ G V+ L PG +ALP + D Sbjct 2686 -LSDGSEAEPLLCVPSLVAPASPYQFARFAQALRGTRDVWVLPTPGCGPGEALPADLDAT 2744 Query 1216 VETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKHQRNPLGVALIDTYLPSQIA 1275 ++A++ G L YSSGG LA+ L + L P + L+DT P+ Sbjct 2745 AARQADAVLRAFGDKP-LTLVAYSSGGWLAHTLAARLEAAGT-PPRALVLLDT--PAGAG 2800 Query 1276 NPSMNEGFSPNDTGKGLSREVIRVARMLNRLTA--TRLTAAATYAAIFQAWEPGRSMAPV 1333 ++ G++ R+ R ++ +LTA A YA +F W P P Sbjct 2801 ----------DNLALGMAATTHRLMRRFPQIPVDDDQLTAMAHYARLFSGWRPRPIETPT 2850 Query 1334 LNIVAKDRIATVENLREERINRWRTAAAEAAYSVAEVPGDHFGMMSTSSEAIATEIHDWI 1393 L + A + + E L E W + EV G+HF ++ +E A +H+W+ Sbjct 2851 LFVQAAEFVP--ELLLEAMRPSW-----PLDHQALEVTGNHFTLLEADAETTAQRVHEWL 2903 Query 1394 S 1394 + Sbjct 2904 N 2904 Lambda K H 0.319 0.134 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 3609289923766 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40