BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0510 Length=309 Score E Sequences producing significant alignments: (Bits) Value gi|15839903|ref|NP_334940.1| porphobilinogen deaminase [Mycobact... 590 1e-166 gi|15607651|ref|NP_215024.1| porphobilinogen deaminase [Mycobact... 589 2e-166 gi|340625538|ref|YP_004743990.1| putative porphobilinogen deamin... 587 1e-165 gi|240171918|ref|ZP_04750577.1| porphobilinogen deaminase [Mycob... 542 3e-152 gi|183980868|ref|YP_001849159.1| porphobilinogen deaminase HemC ... 539 2e-151 gi|118619687|ref|YP_908019.1| porphobilinogen deaminase [Mycobac... 535 2e-150 gi|118467030|ref|YP_883768.1| porphobilinogen deaminase [Mycobac... 526 2e-147 gi|41410101|ref|NP_962937.1| porphobilinogen deaminase [Mycobact... 524 7e-147 gi|254821058|ref|ZP_05226059.1| porphobilinogen deaminase [Mycob... 524 8e-147 gi|15828303|ref|NP_302566.1| porphobilinogen deaminase [Mycobact... 511 5e-143 gi|296168169|ref|ZP_06850190.1| hydroxymethylbilane synthase [My... 511 6e-143 gi|13627125|sp|Q49808.2|HEM3_MYCLE RecName: Full=Porphobilinogen... 510 9e-143 gi|467039|gb|AAA17223.1| hem3b [Mycobacterium leprae] 507 7e-142 gi|108797657|ref|YP_637854.1| porphobilinogen deaminase [Mycobac... 489 2e-136 gi|126433281|ref|YP_001068972.1| porphobilinogen deaminase [Myco... 488 4e-136 gi|120401860|ref|YP_951689.1| porphobilinogen deaminase [Mycobac... 484 7e-135 gi|342858985|ref|ZP_08715639.1| porphobilinogen deaminase [Mycob... 483 1e-134 gi|118472022|ref|YP_885356.1| porphobilinogen deaminase [Mycobac... 481 7e-134 gi|145220672|ref|YP_001131350.1| porphobilinogen deaminase [Myco... 478 4e-133 gi|333989145|ref|YP_004521759.1| porphobilinogen deaminase HemC ... 469 3e-130 gi|169631071|ref|YP_001704720.1| porphobilinogen deaminase [Myco... 457 6e-127 gi|111019045|ref|YP_702017.1| porphobilinogen deaminase [Rhodoco... 439 3e-121 gi|226361138|ref|YP_002778916.1| porphobilinogen deaminase [Rhod... 436 2e-120 gi|229490699|ref|ZP_04384537.1| porphobilinogen deaminase [Rhodo... 429 2e-118 gi|226305131|ref|YP_002765089.1| porphobilinogen deaminase [Rhod... 429 3e-118 gi|312141093|ref|YP_004008429.1| hydroxymethylbilane synthase he... 424 1e-116 gi|54027143|ref|YP_121385.1| porphobilinogen deaminase [Nocardia... 422 4e-116 gi|296138401|ref|YP_003645644.1| porphobilinogen deaminase [Tsuk... 417 7e-115 gi|343925963|ref|ZP_08765478.1| porphobilinogen deaminase [Gordo... 410 1e-112 gi|262201010|ref|YP_003272218.1| porphobilinogen deaminase [Gord... 410 2e-112 gi|326383045|ref|ZP_08204734.1| porphobilinogen deaminase [Gordo... 402 5e-110 gi|333918315|ref|YP_004491896.1| Porphobilinogen deaminase [Amyc... 377 1e-102 gi|134103372|ref|YP_001109033.1| porphobilinogen deaminase [Sacc... 357 1e-96 gi|256380712|ref|YP_003104372.1| porphobilinogen deaminase [Acti... 354 9e-96 gi|300782413|ref|YP_003762704.1| hydroxymethylbilane synthase [A... 354 1e-95 gi|302523839|ref|ZP_07276181.1| porphobilinogen deaminase [Strep... 347 1e-93 gi|284992946|ref|YP_003411500.1| porphobilinogen deaminase [Geod... 343 2e-92 gi|311744366|ref|ZP_07718168.1| hydroxymethylbilane synthase [Ae... 333 1e-89 gi|257054363|ref|YP_003132195.1| porphobilinogen deaminase [Sacc... 331 8e-89 gi|331699360|ref|YP_004335599.1| Porphobilinogen deaminase [Pseu... 323 3e-86 gi|309810452|ref|ZP_07704278.1| hydroxymethylbilane synthase [De... 317 2e-84 gi|302870086|ref|YP_003838723.1| porphobilinogen deaminase [Micr... 315 7e-84 gi|238061239|ref|ZP_04605948.1| porphobilinogen deaminase [Micro... 313 3e-83 gi|317123819|ref|YP_004097931.1| hydroxymethylbilane synthase [I... 312 4e-83 gi|145592923|ref|YP_001157220.1| porphobilinogen deaminase [Sali... 311 7e-83 gi|159036094|ref|YP_001535347.1| porphobilinogen deaminase [Sali... 310 3e-82 gi|84494981|ref|ZP_00994100.1| porphobilinogen deaminase [Janiba... 306 3e-81 gi|325001831|ref|ZP_08122943.1| porphobilinogen deaminase [Pseud... 300 3e-79 gi|119714759|ref|YP_921724.1| porphobilinogen deaminase [Nocardi... 294 1e-77 gi|330470294|ref|YP_004408037.1| porphobilinogen deaminase [Verr... 289 3e-76 >gi|15839903|ref|NP_334940.1| porphobilinogen deaminase [Mycobacterium tuberculosis CDC1551] gi|253797442|ref|YP_003030443.1| porphobilinogen deaminase hemC [Mycobacterium tuberculosis KZN 1435] gi|254363472|ref|ZP_04979518.1| porphobilinogen deaminase hemC [Mycobacterium tuberculosis str. Haarlem] 28 more sequence titles Length=312 Score = 590 bits (1521), Expect = 1e-166, Method: Compositional matrix adjust. Identities = 309/309 (100%), Positives = 309/309 (100%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE Sbjct 4 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 63 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS Sbjct 64 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 123 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE Sbjct 124 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 183 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA Sbjct 184 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 243 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA Sbjct 244 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 303 Query 301 RELMWGVRH 309 RELMWGVRH Sbjct 304 RELMWGVRH 312 >gi|15607651|ref|NP_215024.1| porphobilinogen deaminase [Mycobacterium tuberculosis H37Rv] gi|31791692|ref|NP_854185.1| porphobilinogen deaminase [Mycobacterium bovis AF2122/97] gi|121636428|ref|YP_976651.1| porphobilinogen deaminase [Mycobacterium bovis BCG str. Pasteur 1173P2] 52 more sequence titles Length=309 Score = 589 bits (1518), Expect = 2e-166, Method: Compositional matrix adjust. Identities = 308/309 (99%), Positives = 309/309 (100%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS Sbjct 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA Sbjct 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 Query 301 RELMWGVRH 309 RELMWGVRH Sbjct 301 RELMWGVRH 309 >gi|340625538|ref|YP_004743990.1| putative porphobilinogen deaminase HEMC [Mycobacterium canettii CIPT 140010059] gi|340003728|emb|CCC42853.1| putative porphobilinogen deaminase HEMC (PBG) (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase) [Mycobacterium canettii CIPT 140010059] Length=309 Score = 587 bits (1512), Expect = 1e-165, Method: Compositional matrix adjust. Identities = 307/309 (99%), Positives = 308/309 (99%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 AMEAGLVDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS Sbjct 61 AMEAGLVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA Sbjct 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 Query 301 RELMWGVRH 309 RELMWGVRH Sbjct 301 RELMWGVRH 309 >gi|240171918|ref|ZP_04750577.1| porphobilinogen deaminase [Mycobacterium kansasii ATCC 12478] Length=317 Score = 542 bits (1396), Expect = 3e-152, Method: Compositional matrix adjust. Identities = 283/309 (92%), Positives = 293/309 (95%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAATVRDALIA GH AELVTIST GDRS API +LGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAATVRDALIANGHPAELVTISTAGDRSSAPIETLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHS+KDLPTA DPRFT+AAIPPRNDPRDAVVARDGL LGELP GSLVGTS Sbjct 61 AIEDGRVDAAVHSHKDLPTAEDPRFTIAAIPPRNDPRDAVVARDGLVLGELPAGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLDDVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRA D RL AVLAELDDADTRAAVTAERALLA+LEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAVECRAADHRLAAVLAELDDADTRAAVTAERALLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDE+GRVFEELSLRGCVAALDGSDVIRASG+G+ GRARELGLSVAAELFELGA Sbjct 241 IAEVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGVGTSGRARELGLSVAAELFELGA 300 Query 301 RELMWGVRH 309 RELMWG R Sbjct 301 RELMWGARQ 309 >gi|183980868|ref|YP_001849159.1| porphobilinogen deaminase HemC [Mycobacterium marinum M] gi|238054421|sp|B2HRJ2.1|HEM3_MYCMM RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|183174194|gb|ACC39304.1| porphobilinogen deaminase HemC [Mycobacterium marinum M] Length=314 Score = 539 bits (1388), Expect = 2e-151, Method: Compositional matrix adjust. Identities = 281/306 (92%), Positives = 294/306 (97%), Gaps = 0/306 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAATVRDALIA GH+AELVTIST GDRS API +LGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAATVRDALIANGHAAELVTISTLGDRSSAPIETLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHS+KDLPTA DPRFT+AAIPPR DPRDAVVARDGL LGELPVGSLVGTS Sbjct 61 AIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPPRQDPRDAVVARDGLVLGELPVGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VS+GDLDAIVVARAGLARLGRLDDVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALA+ECRAGDSRL VLAELDDADTRAAVTAERALLA+LEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDE+GRVFEELSLRGCVAALDGSDVIRASGIG+ GRARELGL+VAAELFELGA Sbjct 241 IAEVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVAAELFELGA 300 Query 301 RELMWG 306 RELMWG Sbjct 301 RELMWG 306 >gi|118619687|ref|YP_908019.1| porphobilinogen deaminase [Mycobacterium ulcerans Agy99] gi|158512390|sp|A0PW29.1|HEM3_MYCUA RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|118571797|gb|ABL06548.1| porphobilinogen deaminase HemC [Mycobacterium ulcerans Agy99] Length=314 Score = 535 bits (1379), Expect = 2e-150, Method: Compositional matrix adjust. Identities = 279/306 (92%), Positives = 292/306 (96%), Gaps = 0/306 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAA VRDALIA GH+AELVTIST GDRS API +LGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAAIVRDALIANGHAAELVTISTLGDRSSAPIETLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHS+KDLPTA DPRFT+AAIPPR DPRDAVVARDGL LGELPVGSLVGTS Sbjct 61 AIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPPRQDPRDAVVARDGLVLGELPVGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQ RALGLGLEIRPLRGNLDTRLN+VS+GDLDAIVVARAGLARLGRLDDVTETLE Sbjct 121 SPRRAAQFRALGLGLEIRPLRGNLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALA+ECRAGDSRL VLAELDDADTRAAVTAERALLA+LEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDE+GRVFEELSLRGCVAALDGSDVIRASGIG+ GRARELGL+VAAELFELGA Sbjct 241 IAEVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVAAELFELGA 300 Query 301 RELMWG 306 RELMWG Sbjct 301 RELMWG 306 >gi|118467030|ref|YP_883768.1| porphobilinogen deaminase [Mycobacterium avium 104] gi|158512461|sp|A0QLI0.1|HEM3_MYCA1 RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|118168317|gb|ABK69214.1| porphobilinogen deaminase [Mycobacterium avium 104] Length=315 Score = 526 bits (1355), Expect = 2e-147, Method: Compositional matrix adjust. Identities = 280/309 (91%), Positives = 289/309 (94%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQA VRDALIA GH AELVTI+T GDRS PI SLGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHS+KDLPTA DPRF VAAIP RNDPRDAVVARDGL LGELP GSLVGTS Sbjct 61 AIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLGELPPGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRL DVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGDSRL AVLAELDDADTRA+VTAERALLA+LEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDEDGR+FEELSLRGCVAALDGSDVIRASGIG+ GRARELGLSVAAELFELGA Sbjct 241 IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA 300 Query 301 RELMWGVRH 309 RELM G RH Sbjct 301 RELMSGARH 309 >gi|41410101|ref|NP_962937.1| porphobilinogen deaminase [Mycobacterium avium subsp. paratuberculosis K-10] gi|254777076|ref|ZP_05218592.1| porphobilinogen deaminase [Mycobacterium avium subsp. avium ATCC 25291] gi|55976459|sp|Q73SS0.1|HEM3_MYCPA RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|41398934|gb|AAS06553.1| HemC [Mycobacterium avium subsp. paratuberculosis K-10] gi|336460523|gb|EGO39418.1| porphobilinogen deaminase [Mycobacterium avium subsp. paratuberculosis S397] Length=315 Score = 524 bits (1349), Expect = 7e-147, Method: Compositional matrix adjust. Identities = 279/309 (91%), Positives = 288/309 (94%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQA VRDALIA GH AELVTI+T GDRS PI SLGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHS+KDLPTA DPRF VAAIP RNDPRDAVVARDGL L ELP GSLVGTS Sbjct 61 AIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRL DVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGDSRL AVLAELDDADTRA+VTAERALLA+LEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDEDGR+FEELSLRGCVAALDGSDVIRASGIG+ GRARELGLSVAAELFELGA Sbjct 241 IAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA 300 Query 301 RELMWGVRH 309 RELM G RH Sbjct 301 RELMSGARH 309 >gi|254821058|ref|ZP_05226059.1| porphobilinogen deaminase [Mycobacterium intracellulare ATCC 13950] Length=315 Score = 524 bits (1349), Expect = 8e-147, Method: Compositional matrix adjust. Identities = 278/309 (90%), Positives = 288/309 (94%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQA VRDALIA GH AELVTI+T GDRS PI SLGVGVFTTALRE Sbjct 1 MIRIGTRGSLLATTQAGVVRDALIALGHPAELVTITTAGDRSSGPIESLGVGVFTTALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 AME G VDAAVHS+KDLPTA DPRF VAAIP RNDPRDAVVARDGL LGELP GSLVGTS Sbjct 61 AMEEGRVDAAVHSHKDLPTADDPRFAVAAIPVRNDPRDAVVARDGLVLGELPPGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLDDVTETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGD+RL AVLAELDDADTRA+VTAER LLA+LEAGCSAPVGA Sbjct 181 PVQMLPAPAQGALAVECRAGDTRLAAVLAELDDADTRASVTAERTLLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDE+GR+FEELSLRGCVAALDGSDVIRASGIG+ GRARELGLSVAAELFELGA Sbjct 241 IAEVVESIDEEGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGA 300 Query 301 RELMWGVRH 309 RELM G R Sbjct 301 RELMRGARQ 309 >gi|15828303|ref|NP_302566.1| porphobilinogen deaminase [Mycobacterium leprae TN] gi|221230780|ref|YP_002504196.1| porphobilinogen deaminase [Mycobacterium leprae Br4923] gi|13093996|emb|CAC31937.1| porphobilinogen deaminase [Mycobacterium leprae] gi|219933887|emb|CAR72519.1| porphobilinogen deaminase [Mycobacterium leprae Br4923] Length=318 Score = 511 bits (1316), Expect = 5e-143, Method: Compositional matrix adjust. Identities = 269/308 (88%), Positives = 283/308 (92%), Gaps = 0/308 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 VIRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR Sbjct 4 VIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 63 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS Sbjct 64 AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 123 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+ Sbjct 124 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 183 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQM+PAPAQGA+AVECRAGDSRLVAVLA LDDADTRAAVTAER LLA+LEAGCSAPVGA Sbjct 184 PVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPVGA 243 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA Sbjct 244 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 303 Query 301 RELMWGVR 308 RELMWG R Sbjct 304 RELMWGAR 311 >gi|296168169|ref|ZP_06850190.1| hydroxymethylbilane synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295896847|gb|EFG76476.1| hydroxymethylbilane synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=317 Score = 511 bits (1315), Expect = 6e-143, Method: Compositional matrix adjust. Identities = 272/309 (89%), Positives = 284/309 (92%), Gaps = 1/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 VIRIGTRGSLLATTQA VRDALIA GH AELV I+T GDRS API +LGVG FTTALRE Sbjct 4 VIRIGTRGSLLATTQAGVVRDALIANGHPAELVIITTAGDRSSAPIETLGVGAFTTALRE 63 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ G VDAAVHS+KDLPTA DPRFT+AAIPPRNDPRD VVARDGL LGELP GSLVGTS Sbjct 64 AINDGRVDAAVHSHKDLPTADDPRFTIAAIPPRNDPRDVVVARDGLVLGELPPGSLVGTS 123 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLDDVTETLE Sbjct 124 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDDVTETLE 183 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGD L AVLAELDDADTRA+VTAERALLA+LEAGCSAPVGA Sbjct 184 PVQMLPAPAQGALAVECRAGDG-LAAVLAELDDADTRASVTAERALLAELEAGCSAPVGA 242 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVES+DE+GRVFEELSLRGCVAALDGSDVIRASGIG+ RARELG+SVAAELFELGA Sbjct 243 IAEVVESLDEEGRVFEELSLRGCVAALDGSDVIRASGIGTADRARELGVSVAAELFELGA 302 Query 301 RELMWGVRH 309 RELM R Sbjct 303 RELMAEARQ 311 >gi|13627125|sp|Q49808.2|HEM3_MYCLE RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase Length=315 Score = 510 bits (1314), Expect = 9e-143, Method: Compositional matrix adjust. Identities = 268/308 (88%), Positives = 283/308 (92%), Gaps = 0/308 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR Sbjct 1 MIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS Sbjct 61 AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLARLGRLD+VTETL+ Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLD 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQM+PAPAQGA+AVECRAGDSRLVAVLA LDDADTRAAVTAER LLA+LEAGCSAPVGA Sbjct 181 PVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA Sbjct 241 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 300 Query 301 RELMWGVR 308 RELMWG R Sbjct 301 RELMWGAR 308 >gi|467039|gb|AAA17223.1| hem3b [Mycobacterium leprae] Length=315 Score = 507 bits (1306), Expect = 7e-142, Method: Compositional matrix adjust. Identities = 267/309 (87%), Positives = 282/309 (92%), Gaps = 0/309 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQAA VRDALIA GH AELV ++T GD+S A I SLGVGVFTTALR Sbjct 1 MIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRA 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+E G VDAAVHSYKDLPTA DPRFTVAAIPPRNDPRDAVV RD L L ELP GSLVGTS Sbjct 61 AIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSGDLDAIVVARAGLAR GRLD+VTETL+ Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARPGRLDEVTETLD 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQM+PAPAQGA+AVECRAGDSRLVAVLA LDDADTRAAVTAER LLA+LEAGCSAPVGA Sbjct 181 PVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IA+VVESID +GRVFEELSLRGCVAALDGSDVIRASGI + GRA ELGL+VA ELFELGA Sbjct 241 IAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGA 300 Query 301 RELMWGVRH 309 RELMWG R Sbjct 301 RELMWGARS 309 >gi|108797657|ref|YP_637854.1| porphobilinogen deaminase [Mycobacterium sp. MCS] gi|119866744|ref|YP_936696.1| porphobilinogen deaminase [Mycobacterium sp. KMS] gi|108768076|gb|ABG06798.1| hydroxymethylbilane synthase [Mycobacterium sp. MCS] gi|119692833|gb|ABL89906.1| hydroxymethylbilane synthase [Mycobacterium sp. KMS] Length=314 Score = 489 bits (1259), Expect = 2e-136, Method: Compositional matrix adjust. Identities = 258/303 (86%), Positives = 278/303 (92%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 IRIGTR SLLATTQA T+RDALIA GH+AELV ISTEGDR+ PIA +GVGVFT ALREA Sbjct 8 IRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVFTAALREA 67 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VDAAVHSYKDLPTAAD RFT+ AIP R DPRDA+VARDGL LGELP GS VGTSS Sbjct 68 IHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSS 127 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRAAQLRALGLGLEIRPLRGNLDTRLN+V +G+LD IVVARAGLAR+GRL DVTETLEP Sbjct 128 PRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGDVTETLEP 187 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVECRAGD+ L+A+LAELDDADTRAAVTAER LLA+LEAGCSAPVGAI Sbjct 188 VQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGCSAPVGAI 247 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVESIDEDGRVFEE+SLRGCVAALDGSDVIRASGIG+ GRA +LG+SVAAELFELGAR Sbjct 248 AEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGAR 307 Query 302 ELM 304 EL+ Sbjct 308 ELI 310 >gi|126433281|ref|YP_001068972.1| porphobilinogen deaminase [Mycobacterium sp. JLS] gi|126233081|gb|ABN96481.1| hydroxymethylbilane synthase [Mycobacterium sp. JLS] Length=314 Score = 488 bits (1256), Expect = 4e-136, Method: Compositional matrix adjust. Identities = 257/303 (85%), Positives = 277/303 (92%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 IRIGTR SLLATTQA T+RDALI GH+AELV ISTEGDR+ PIA +GVGVFT ALREA Sbjct 8 IRIGTRASLLATTQAGTIRDALIGRGHAAELVLISTEGDRNQGPIADIGVGVFTAALREA 67 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VDAAVHSYKDLPTAAD RFT+ AIP R DPRDA+VARDGL LGELP GS VGTSS Sbjct 68 IHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSS 127 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRAAQLRALGLGLEIRPLRGNLDTRLN+V +G+LD IVVARAGLAR+GRL DVTETLEP Sbjct 128 PRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGDVTETLEP 187 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVECRAGD+ L+A+LAELDDADTRAAVTAER LLA+LEAGCSAPVGAI Sbjct 188 VQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGCSAPVGAI 247 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVESIDEDGRVFEE+SLRGCVAALDGSDVIRASGIG+ GRA +LG+SVAAELFELGAR Sbjct 248 AEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGAR 307 Query 302 ELM 304 EL+ Sbjct 308 ELI 310 >gi|120401860|ref|YP_951689.1| porphobilinogen deaminase [Mycobacterium vanbaalenii PYR-1] gi|158513128|sp|A1T3D3.1|HEM3_MYCVP RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|119954678|gb|ABM11683.1| hydroxymethylbilane synthase [Mycobacterium vanbaalenii PYR-1] Length=312 Score = 484 bits (1246), Expect = 7e-135, Method: Compositional matrix adjust. Identities = 256/305 (84%), Positives = 277/305 (91%), Gaps = 1/305 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGD-RSMAPIASLGVGVFTTALR 59 +IRIGTRGSLLATTQA TVRDALIA GH AELV +STEGD R+ APIA +GVGVFT ALR Sbjct 1 MIRIGTRGSLLATTQAGTVRDALIAAGHDAELVIVSTEGDQRADAPIAEIGVGVFTAALR 60 Query 60 EAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGT 119 EA+ GLVDAAVHSYKDLPTA DPRF +AA P R D RDA+VARDGL LGELP GS++GT Sbjct 61 EAIADGLVDAAVHSYKDLPTAPDPRFMIAATPVREDARDALVARDGLVLGELPAGSVIGT 120 Query 120 SSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETL 179 SSPRRAAQLRALGLGLEIRPLRGNLDTRLN+VSSG+LDAIVVARAGLAR+GRLD VTE L Sbjct 121 SSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGELDAIVVARAGLARIGRLDAVTEAL 180 Query 180 EPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVG 239 EPVQMLPAPAQGALAVECRAGD+ L VL++LDDADTRAA+TAER LLA+LEAGCSAPVG Sbjct 181 EPVQMLPAPAQGALAVECRAGDTALAQVLSQLDDADTRAAITAERTLLAELEAGCSAPVG 240 Query 240 AIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELG 299 AIAEVVESIDEDGRVFEELSLRGCVA LDGSDVIRA+GIG+ RARELGLSVA ELFELG Sbjct 241 AIAEVVESIDEDGRVFEELSLRGCVATLDGSDVIRATGIGTPDRARELGLSVAEELFELG 300 Query 300 ARELM 304 AR+L+ Sbjct 301 ARDLL 305 >gi|342858985|ref|ZP_08715639.1| porphobilinogen deaminase [Mycobacterium colombiense CECT 3035] gi|342133226|gb|EGT86429.1| porphobilinogen deaminase [Mycobacterium colombiense CECT 3035] Length=293 Score = 483 bits (1244), Expect = 1e-134, Method: Compositional matrix adjust. Identities = 256/287 (90%), Positives = 266/287 (93%), Gaps = 0/287 (0%) Query 23 LIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAAD 82 +IA GH AELVTI+T GDRS PI SLGVGVFTTALREAME G VDAAVHS+KDLPTA D Sbjct 1 MIALGHPAELVTITTAGDRSSEPIESLGVGVFTTALREAMEEGRVDAAVHSHKDLPTADD 60 Query 83 PRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRG 142 PRF VAAIP RNDPRDAVVARDGL L ELP GSLVGTSSPRRAAQLRALGLGLEIRPLRG Sbjct 61 PRFAVAAIPLRNDPRDAVVARDGLVLAELPAGSLVGTSSPRRAAQLRALGLGLEIRPLRG 120 Query 143 NLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGALAVECRAGDS 202 NLDTRLN+VSSGDLDAIVVARAGLAR+GRLDDVTETLEPVQMLPAPAQGALAVECRAGD+ Sbjct 121 NLDTRLNRVSSGDLDAIVVARAGLARIGRLDDVTETLEPVQMLPAPAQGALAVECRAGDT 180 Query 203 RLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDEDGRVFEELSLRG 262 RL AVLAELDDADTRA+VTAERALLA+LEAGCSAPVGAIAEVVESIDE+GR+FEELSLRG Sbjct 181 RLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGAIAEVVESIDEEGRIFEELSLRG 240 Query 263 CVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVRH 309 CVAALDGSDVIRASGIGS RARELGLSVAAELFELGARELM R Sbjct 241 CVAALDGSDVIRASGIGSPDRARELGLSVAAELFELGARELMSEARQ 287 >gi|118472022|ref|YP_885356.1| porphobilinogen deaminase [Mycobacterium smegmatis str. MC2 155] gi|118173309|gb|ABK74205.1| porphobilinogen deaminase [Mycobacterium smegmatis str. MC2 155] Length=318 Score = 481 bits (1238), Expect = 7e-134, Method: Compositional matrix adjust. Identities = 249/304 (82%), Positives = 274/304 (91%), Gaps = 0/304 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 VIR+GTRGSLLATTQA TVRDAL+A GH ELV ISTEGDR+ PIA +G+GVFT ALRE Sbjct 8 VIRLGTRGSLLATTQAGTVRDALLAAGHPCELVIISTEGDRNQGPIADIGIGVFTAALRE 67 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ G VD AVHSYKDLPTA+D RF + AIP R DPRDA+VARDGL LGELP GS++GTS Sbjct 68 AIHDGRVDMAVHSYKDLPTASDERFCIPAIPRREDPRDALVARDGLVLGELPTGSVIGTS 127 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRLN+V+SG+LD IVVARAGLAR+GRL+ VTETLE Sbjct 128 SPRRAAQLRALGLGLEIRPLRGNLDTRLNRVTSGELDGIVVARAGLARIGRLNVVTETLE 187 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQMLPAPAQGALAVECRAGD+ L+A+L+ELDDADTRAAVTAER LLA+LEAGCSAPVGA Sbjct 188 PVQMLPAPAQGALAVECRAGDTELIAILSELDDADTRAAVTAERVLLAELEAGCSAPVGA 247 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDEDG VFEELSLRGC A LDGSDVIRASGIG+ RA ELG+SVAAELF+LGA Sbjct 248 IAEVVESIDEDGNVFEELSLRGCAATLDGSDVIRASGIGTPDRAAELGVSVAAELFDLGA 307 Query 301 RELM 304 REL+ Sbjct 308 RELL 311 >gi|145220672|ref|YP_001131350.1| porphobilinogen deaminase [Mycobacterium gilvum PYR-GCK] gi|315442377|ref|YP_004075256.1| hydroxymethylbilane synthase [Mycobacterium sp. Spyr1] gi|189028094|sp|A4T340.1|HEM3_MYCGI RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|145213158|gb|ABP42562.1| hydroxymethylbilane synthase [Mycobacterium gilvum PYR-GCK] gi|315260680|gb|ADT97421.1| hydroxymethylbilane synthase [Mycobacterium sp. Spyr1] Length=312 Score = 478 bits (1231), Expect = 4e-133, Method: Compositional matrix adjust. Identities = 251/305 (83%), Positives = 275/305 (91%), Gaps = 1/305 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSM-APIASLGVGVFTTALR 59 +IRIGTRGSLLATTQA T+RDALIA GH AELV ISTEGDR PIA +GVGVFT ALR Sbjct 1 MIRIGTRGSLLATTQAGTIRDALIAAGHDAELVIISTEGDRRADEPIADIGVGVFTAALR 60 Query 60 EAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGT 119 EA+ +VDAAVHSYKDLPTA DPRF +AA P R D RDA+VARDG+ LGELP GS++GT Sbjct 61 EAIADNVVDAAVHSYKDLPTAVDPRFMIAATPVREDARDALVARDGMVLGELPAGSVIGT 120 Query 120 SSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETL 179 SSPRR AQL+ALGLGLEIRPLRGNLDTRLN+VSSG+LDAIVVA+AGL+R+GRL+ VTETL Sbjct 121 SSPRRVAQLKALGLGLEIRPLRGNLDTRLNRVSSGELDAIVVAKAGLSRIGRLEVVTETL 180 Query 180 EPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVG 239 EPVQMLPAPAQGALA+ECRAGD+ L +LAELDDADTRAAVTAER LLA+LEAGCSAPVG Sbjct 181 EPVQMLPAPAQGALAIECRAGDTALAQLLAELDDADTRAAVTAERTLLAELEAGCSAPVG 240 Query 240 AIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELG 299 AIAEVVESIDEDGRVFEELSLRGCVA LDGSDVIRASGIGS RARELGLSVAAELF+LG Sbjct 241 AIAEVVESIDEDGRVFEELSLRGCVATLDGSDVIRASGIGSPDRARELGLSVAAELFDLG 300 Query 300 ARELM 304 AR+L+ Sbjct 301 ARDLL 305 >gi|333989145|ref|YP_004521759.1| porphobilinogen deaminase HemC [Mycobacterium sp. JDM601] gi|333485113|gb|AEF34505.1| porphobilinogen deaminase HemC [Mycobacterium sp. JDM601] Length=299 Score = 469 bits (1207), Expect = 3e-130, Method: Compositional matrix adjust. Identities = 250/299 (84%), Positives = 267/299 (90%), Gaps = 0/299 (0%) Query 10 LLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDA 69 +LATTQA TVRDAL+A GH AELV IST GDRS PIA LGVGVFT ALREA+ G VDA Sbjct 1 MLATTQAGTVRDALVAAGHPAELVMISTIGDRSSGPIADLGVGVFTAALREAILDGRVDA 60 Query 70 AVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLR 129 AVHS+KDLPTA DPRF + A+P R DPRDA+VARDGL LGELP G+ +GTSSPRRAAQLR Sbjct 61 AVHSHKDLPTADDPRFLLPAVPAREDPRDALVARDGLVLGELPAGARLGTSSPRRAAQLR 120 Query 130 ALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPA 189 ALGLGLEIRPLRGNLDTRLN+VSSG+LDAIVVARAGLAR+GRLD +TETLEPVQMLPAPA Sbjct 121 ALGLGLEIRPLRGNLDTRLNRVSSGELDAIVVARAGLARIGRLDAITETLEPVQMLPAPA 180 Query 190 QGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESID 249 QGALAVECRAGD+ L A+LAELDD DTR AVTAER LLA+LEAGCSAPVGAIAEVVESID Sbjct 181 QGALAVECRAGDTGLAALLAELDDTDTRQAVTAERTLLAELEAGCSAPVGAIAEVVESID 240 Query 250 EDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELMWGVR 308 EDGRVFEELSLR CVAALDGSDVIRASGIGS RARELG+SVAAELFELGARELM R Sbjct 241 EDGRVFEELSLRSCVAALDGSDVIRASGIGSPDRARELGVSVAAELFELGARELMSDAR 299 >gi|169631071|ref|YP_001704720.1| porphobilinogen deaminase [Mycobacterium abscessus ATCC 19977] gi|238054424|sp|B1MHI5.1|HEM3_MYCA9 RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|169243038|emb|CAM64066.1| Porphobilinogen deaminase (HemC) [Mycobacterium abscessus] Length=306 Score = 457 bits (1177), Expect = 6e-127, Method: Compositional matrix adjust. Identities = 240/304 (79%), Positives = 270/304 (89%), Gaps = 0/304 (0%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +IRIGTRGSLLATTQA +RDAL A GH AELV ++T GD+S AP+ +GVGVFT ALRE Sbjct 1 MIRIGTRGSLLATTQAGGIRDALRAKGHEAELVIVTTAGDQSAAPVEQIGVGVFTAALRE 60 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ +VD AVHSYKDLPTAADPRF + AIPPR D RDA+VARDGL LGELP GS++GTS Sbjct 61 AIADDVVDVAVHSYKDLPTAADPRFVIPAIPPREDYRDALVARDGLVLGELPAGSVIGTS 120 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQLRALGLGLEIRPLRGNLDTRL++VS+GDLD +VVARAGLAR+GRLD +TETLE Sbjct 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLSRVSNGDLDGVVVARAGLARIGRLDHITETLE 180 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 PVQ+LPAPAQGALAVECR+ + LVAVLAELD ADTRAAVTAERALLA+LEAGC+APVGA Sbjct 181 PVQVLPAPAQGALAVECRSEATDLVAVLAELDHADTRAAVTAERALLAELEAGCTAPVGA 240 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 IAEVVESIDE+GRVF+ELSLRGC AALDGSDVIRASGIG+ RA ELGL+VA EL +LGA Sbjct 241 IAEVVESIDEEGRVFDELSLRGCAAALDGSDVIRASGIGTPDRAAELGLAVARELLDLGA 300 Query 301 RELM 304 R L+ Sbjct 301 RALI 304 >gi|111019045|ref|YP_702017.1| porphobilinogen deaminase [Rhodococcus jostii RHA1] gi|110818575|gb|ABG93859.1| hydroxymethylbilane synthase [Rhodococcus jostii RHA1] Length=321 Score = 439 bits (1129), Expect = 3e-121, Method: Compositional matrix adjust. Identities = 225/303 (75%), Positives = 260/303 (86%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGS LATTQA TVRDALI+ GH AELV I T+GD+SM + +GVGVFT LREA Sbjct 9 LRIGTRGSELATTQAGTVRDALISAGHDAELVIIKTKGDQSMESVEKIGVGVFTAELREA 68 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VD AVHSYKDLPTA D RFT+AAIPPR DPRDA+VARDGL LGELP GS VGTS+ Sbjct 69 LADGRVDVAVHSYKDLPTAPDERFTIAAIPPREDPRDALVARDGLVLGELPAGSKVGTSA 128 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR +QLRALGLGL+IRPLRGNL RL KV SG+LDA+V+ARAGLAR+GRLD +TE++EP Sbjct 129 PRRTSQLRALGLGLDIRPLRGNLQRRLGKVESGELDAVVLARAGLARIGRLDLITESIEP 188 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVEC + ++ LVA+L+ELDD ++RAAVTAERALLA+LEAGC+APVGAI Sbjct 189 VQMLPAPAQGALAVECLSANTALVAILSELDDPNSRAAVTAERALLAELEAGCTAPVGAI 248 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVES+D+DGR+F+ELS+RGC AA+DGSDVIR +GS A ELG SVA EL ELGAR Sbjct 249 AEVVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGSPENAEELGRSVARELLELGAR 308 Query 302 ELM 304 ELM Sbjct 309 ELM 311 >gi|226361138|ref|YP_002778916.1| porphobilinogen deaminase [Rhodococcus opacus B4] gi|226239623|dbj|BAH49971.1| porphobilinogen deaminase [Rhodococcus opacus B4] Length=321 Score = 436 bits (1121), Expect = 2e-120, Method: Compositional matrix adjust. Identities = 225/303 (75%), Positives = 259/303 (86%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGS LATTQA TVRDALI+ GH AELV I T+GD+SM + +GVGVFT LREA Sbjct 9 LRIGTRGSELATTQAGTVRDALISAGHDAELVIIKTKGDQSMESVEKIGVGVFTAELREA 68 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VD AVHSYKDLPTA D RFT+AAIPPR DPRDA+VARDGL LGELP GS VGTS+ Sbjct 69 LADGRVDVAVHSYKDLPTARDERFTIAAIPPREDPRDALVARDGLVLGELPPGSKVGTSA 128 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR +QLRALGLGL+I PLRGNL RL KV SG+LDA+V+ARAGLAR+GRLD +TE+LEP Sbjct 129 PRRTSQLRALGLGLDILPLRGNLQRRLGKVESGELDAVVLARAGLARIGRLDLITESLEP 188 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVEC + ++ LVA+L+ELDD ++RAAVTAERALLA+LEAGC+APVGAI Sbjct 189 VQMLPAPAQGALAVECLSANTALVAILSELDDPNSRAAVTAERALLAELEAGCTAPVGAI 248 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVES+D+DGR+F+ELS+RGC AA+DGSDVIR +GS A ELG SVA EL ELGAR Sbjct 249 AEVVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGSPENAEELGRSVARELLELGAR 308 Query 302 ELM 304 ELM Sbjct 309 ELM 311 >gi|229490699|ref|ZP_04384537.1| porphobilinogen deaminase [Rhodococcus erythropolis SK121] gi|229322519|gb|EEN88302.1| porphobilinogen deaminase [Rhodococcus erythropolis SK121] Length=324 Score = 429 bits (1104), Expect = 2e-118, Method: Compositional matrix adjust. Identities = 219/303 (73%), Positives = 255/303 (85%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGSLLATTQA TVRDALIA GH AELV I T+GD+S P+ +GVGVFT LREA Sbjct 12 LRIGTRGSLLATTQAGTVRDALIAAGHPAELVIIKTKGDQSTDPVQKIGVGVFTAELREA 71 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + VD AVHSYKDLPTA DPRF +AAIPPR DPRDA+VARDGL LGELP GS VGTS+ Sbjct 72 LVDNRVDVAVHSYKDLPTAQDPRFVIAAIPPREDPRDALVARDGLVLGELPAGSKVGTSA 131 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR +QL+ALGLGL+I PLRGNL RL KV SG+LDA+++ARAGL+R+G LD +TE +EP Sbjct 132 PRRVSQLKALGLGLDIVPLRGNLQRRLGKVESGELDAVILARAGLSRIGLLDLITENIEP 191 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVEC + ++ L A+LAE DDA TRAAVTAERALLA LEAGC+APVGAI Sbjct 192 VQMLPAPAQGALAVECLSANAELAAILAEHDDAGTRAAVTAERALLAGLEAGCTAPVGAI 251 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AE+VES+D+DGR+F+ELS+RGC AA+DGSDVIR +G+ +A ELG +VA EL ELGAR Sbjct 252 AEIVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGAPDKAEELGRAVARELLELGAR 311 Query 302 ELM 304 ELM Sbjct 312 ELM 314 >gi|226305131|ref|YP_002765089.1| porphobilinogen deaminase [Rhodococcus erythropolis PR4] gi|226184246|dbj|BAH32350.1| porphobilinogen deaminase [Rhodococcus erythropolis PR4] Length=324 Score = 429 bits (1103), Expect = 3e-118, Method: Compositional matrix adjust. Identities = 219/303 (73%), Positives = 255/303 (85%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGSLLATTQA TVRDALIA GH AELV I T+GD+S P+ +GVGVFT LREA Sbjct 12 LRIGTRGSLLATTQAGTVRDALIAAGHPAELVIIKTKGDQSTDPVQKIGVGVFTAELREA 71 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + VD AVHSYKDLPTA DPRF +AAIPPR DPRDA+VARDGL LGELP GS VGTS+ Sbjct 72 LLDNRVDVAVHSYKDLPTAQDPRFVIAAIPPREDPRDALVARDGLVLGELPAGSKVGTSA 131 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR +QL+ALGLGL+I PLRGNL RL KV SG+LDA+++ARAGL+R+G LD +TE +EP Sbjct 132 PRRVSQLKALGLGLDIVPLRGNLQRRLGKVESGELDAVILARAGLSRIGLLDLITENIEP 191 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVEC + + L A+LAE DDA TRAAVTAERALLA+LEAGC+APVGAI Sbjct 192 VQMLPAPAQGALAVECLSANVELAAILAEHDDAGTRAAVTAERALLAELEAGCTAPVGAI 251 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AE+VES+D+DGR+F+ELS+RGC AA+DGSDVIR +G+ +A ELG +VA EL ELGAR Sbjct 252 AEIVESLDDDGRIFDELSVRGCAAAIDGSDVIRTGAVGAPDKAEELGRAVARELLELGAR 311 Query 302 ELM 304 ELM Sbjct 312 ELM 314 >gi|312141093|ref|YP_004008429.1| hydroxymethylbilane synthase hemc [Rhodococcus equi 103S] gi|325674097|ref|ZP_08153787.1| hydroxymethylbilane synthase [Rhodococcus equi ATCC 33707] gi|311890432|emb|CBH49750.1| hydroxymethylbilane synthase HemC [Rhodococcus equi 103S] gi|325555362|gb|EGD25034.1| hydroxymethylbilane synthase [Rhodococcus equi ATCC 33707] Length=334 Score = 424 bits (1089), Expect = 1e-116, Method: Compositional matrix adjust. Identities = 221/303 (73%), Positives = 256/303 (85%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGSLLATTQA VRDALIA GH AELV I T+GD + P+ +GVGVF LREA Sbjct 22 LRIGTRGSLLATTQAGHVRDALIAAGHPAELVIIKTKGDVTAGPVQRIGVGVFVAELREA 81 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + AG VD AVHSYKDLPTA T+AA+P R DPRDA+VARDGL LGELP GS +GTS+ Sbjct 82 LVAGEVDVAVHSYKDLPTAQPDDLTIAAVPTREDPRDALVARDGLVLGELPPGSRIGTSA 141 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR AQLRA+GLGLEI PLRGN+DTRL KV+SG+LDAIV+ARAGL+R+GR + +TETLEP Sbjct 142 PRRRAQLRAMGLGLEIEPLRGNIDTRLGKVASGELDAIVIARAGLSRIGRTERITETLEP 201 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAP+QGALAVECR+ + L+A+L ELDD TRAAV AERALLA+LEAGC+APVGAI Sbjct 202 VQMLPAPSQGALAVECRSDNPDLIAILGELDDHATRAAVVAERALLAELEAGCTAPVGAI 261 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVES+D+DGRVFEELS+RGC AA+DGSDVIRAS +GS RA ELG +VA EL +LGAR Sbjct 262 AEVVESLDDDGRVFEELSIRGCAAAIDGSDVIRASLVGSPERADELGRAVARELLDLGAR 321 Query 302 ELM 304 +LM Sbjct 322 DLM 324 >gi|54027143|ref|YP_121385.1| porphobilinogen deaminase [Nocardia farcinica IFM 10152] gi|61213309|sp|Q5YP70.1|HEM3_NOCFA RecName: Full=Porphobilinogen deaminase; Short=PBG; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase gi|54018651|dbj|BAD60021.1| putative porphobilinogen deaminase [Nocardia farcinica IFM 10152] Length=346 Score = 422 bits (1085), Expect = 4e-116, Method: Compositional matrix adjust. Identities = 220/306 (72%), Positives = 257/306 (84%), Gaps = 0/306 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGSLLA TQA TVRDALIA G AELV + T GD S P+ +GVGVFT+ALR+ Sbjct 10 LRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVGVFTSALRDE 69 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + AG +D AVHSYKDLPTA DPRF +AAIPPR DPRDA+VARDGL LGELP G+ VGTS+ Sbjct 70 LAAGTIDLAVHSYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELPAGAKVGTSA 129 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR AQLRALGLGL+I PLRGNLD+RL +V+ G+LDA+VVARAGL+R+GR +TE LEP Sbjct 130 PRRVAQLRALGLGLDIVPLRGNLDSRLARVTDGELDAVVVARAGLSRIGRTAVITEALEP 189 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVECR+ D+ L+ LAELDDA TRAAV AERALLA+LEAGC+APVGA+ Sbjct 190 VQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEAGCTAPVGAL 249 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVES+D+DGR+ EELSLRGC AA+DGS+V+RAS +G RA ELG ++A EL ELGAR Sbjct 250 AEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALARELLELGAR 309 Query 302 ELMWGV 307 EL+ V Sbjct 310 ELLVEV 315 >gi|296138401|ref|YP_003645644.1| porphobilinogen deaminase [Tsukamurella paurometabola DSM 20162] gi|296026535|gb|ADG77305.1| porphobilinogen deaminase [Tsukamurella paurometabola DSM 20162] Length=318 Score = 417 bits (1073), Expect = 7e-115, Method: Compositional matrix adjust. Identities = 219/303 (73%), Positives = 254/303 (84%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGSLLATTQA TVRDALIA GH AELV ++T GD S P+ +GVGVFT+ALR+A Sbjct 15 LRIGTRGSLLATTQAGTVRDALIAAGHPAELVIVTTPGDLSSDPVEKIGVGVFTSALRDA 74 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VD AVHSYKDLPTA D R +AA+PPR D RDA+VARDG+ LGELP GS+VGTSS Sbjct 75 LANGEVDVAVHSYKDLPTAPDDRLVLAAVPPREDSRDALVARDGMVLGELPAGSVVGTSS 134 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRA QL ALGLGLEIRPLRGNLD+RL KV+ G+LDAIVVA AGL R+GR D+VTE L+P Sbjct 135 PRRATQLTALGLGLEIRPLRGNLDSRLRKVADGELDAIVVALAGLKRIGRHDEVTEALDP 194 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 VQMLPAPAQGALAVECR GD+ L +VL+ELDD TRAAVTAERALLA+LEAGC+APVGAI Sbjct 195 VQMLPAPAQGALAVECRRGDADLQSVLSELDDHWTRAAVTAERALLAELEAGCTAPVGAI 254 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVES+D+DGR+FEELSLRG A DGSD ++AS +G G A LG ++A EL +LGAR Sbjct 255 AEVVESLDDDGRIFEELSLRGIALAADGSDSVKASAVGPVGEAGALGTALARELLDLGAR 314 Query 302 ELM 304 +L+ Sbjct 315 DLL 317 >gi|343925963|ref|ZP_08765478.1| porphobilinogen deaminase [Gordonia alkanivorans NBRC 16433] gi|343764314|dbj|GAA12404.1| porphobilinogen deaminase [Gordonia alkanivorans NBRC 16433] Length=314 Score = 410 bits (1054), Expect = 1e-112, Method: Compositional matrix adjust. Identities = 217/303 (72%), Positives = 251/303 (83%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 IRIGTRGSLLATTQ+ T+ DAL A GH AELV I T GD S AP+A +GVGVFTTA+R A Sbjct 9 IRIGTRGSLLATTQSQTIADALTAAGHPAELVIIKTAGDASAAPVAEIGVGVFTTAIRVA 68 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + VD AVHSYKDLPTA + T+AA+P R DPRDA+V+RD L LGELP GS++GTS+ Sbjct 69 LRDDEVDVAVHSYKDLPTAPEDDLTIAAVPTRVDPRDALVSRDDLVLGELPPGSVIGTSA 128 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRAAQL+ALGLGLEIRPLRGNLD+RL KV+SG+LDA+VVARAGL R+GR + V+E L+P Sbjct 129 PRRAAQLKALGLGLEIRPLRGNLDSRLGKVASGELDAVVVARAGLVRIGRTEVVSEALDP 188 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 V MLPAPAQGALAVECR+ D+ LV +LAELDD TRAA+ AERA+LA LEAGC+APVGAI Sbjct 189 VVMLPAPAQGALAVECRSDDAELVRILAELDDKSTRAAIDAERAVLAALEAGCTAPVGAI 248 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVESIDEDGR+F ELSLR VAA DGSDVIRAS +G RA +LG +AAEL ELGA Sbjct 249 AEVVESIDEDGRIFAELSLRAAVAAEDGSDVIRASAVGPVDRAVQLGKDLAAELLELGAG 308 Query 302 ELM 304 EL+ Sbjct 309 ELV 311 >gi|262201010|ref|YP_003272218.1| porphobilinogen deaminase [Gordonia bronchialis DSM 43247] gi|262084357|gb|ACY20325.1| porphobilinogen deaminase [Gordonia bronchialis DSM 43247] Length=313 Score = 410 bits (1053), Expect = 2e-112, Method: Compositional matrix adjust. Identities = 214/303 (71%), Positives = 251/303 (83%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 IRIGTRGSLLATTQA T+ DAL GH AELV I T GD S AP+A +GVGVFTTA+R A Sbjct 9 IRIGTRGSLLATTQAQTIADALTEAGHPAELVIIRTAGDDSAAPVAEIGVGVFTTAIRIA 68 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + VD AVHSYKDLPTA +P +AA+PPR DPRDA+V+RD + LGELP GS +GTS+ Sbjct 69 LHNREVDVAVHSYKDLPTADEPGLYIAAVPPREDPRDALVSRDNMVLGELPPGSTIGTSA 128 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR AQLRALGLGLEIRPLRGNLD+RL KV+SG+LDA+VVARAGL R+GR D+VTE+ +P Sbjct 129 PRRVAQLRALGLGLEIRPLRGNLDSRLGKVASGELDAVVVARAGLVRIGRADEVTESFDP 188 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 V +LPAPAQGALAVECR+ D++LV +LAELDD TRAA+ AERA+LA LEAGC+AP+GAI Sbjct 189 VVLLPAPAQGALAVECRSDDAQLVRILAELDDESTRAAIDAERAVLAALEAGCTAPIGAI 248 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVVESID+DGR+F ELSLR VAA DGSDVIRAS +G RA +LG +AAEL ELGA Sbjct 249 AEVVESIDDDGRIFAELSLRAAVAAEDGSDVIRASVVGPVDRAAQLGADLAAELLELGAG 308 Query 302 ELM 304 +L+ Sbjct 309 DLV 311 >gi|326383045|ref|ZP_08204734.1| porphobilinogen deaminase [Gordonia neofelifaecis NRRL B-59395] gi|326198181|gb|EGD55366.1| porphobilinogen deaminase [Gordonia neofelifaecis NRRL B-59395] Length=315 Score = 402 bits (1032), Expect = 5e-110, Method: Compositional matrix adjust. Identities = 216/303 (72%), Positives = 249/303 (83%), Gaps = 0/303 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 IRIGTRGSLLATTQA + D L A GH AELV IST GD S AP+A +GVGVFTTA+R A Sbjct 9 IRIGTRGSLLATTQAQDIADRLTAAGHPAELVIISTAGDTSSAPVAQIGVGVFTTAIRLA 68 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + +G D A+HSYKDLPTA + +AA+P R DPRDA+V+RDG+ LGELP GS+VGTSS Sbjct 69 LRSGECDVAIHSYKDLPTAPEDDLAMAAVPTRVDPRDALVSRDGMVLGELPSGSVVGTSS 128 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRAAQLRALGLGLEIRPLRGNLD+RL KV+SG+LDAIVVARAGL R+GR D VTE L+P Sbjct 129 PRRAAQLRALGLGLEIRPLRGNLDSRLGKVASGELDAIVVARAGLVRIGRADVVTEALDP 188 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAI 241 + ML APAQGALAVECR+ D+ LV +LAELDD TRAAV AERA+LA LEAGC+APVGA+ Sbjct 189 LVMLSAPAQGALAVECRSDDAELVRILAELDDPSTRAAVDAERAVLATLEAGCTAPVGAL 248 Query 242 AEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGAR 301 AEVV+SIDEDGR+F ELSLR VAA DGS+VIRAS +G RA +LG +AAEL ELGA Sbjct 249 AEVVDSIDEDGRIFAELSLRAAVAAEDGSEVIRASVVGPVDRAAQLGKDLAAELLELGAA 308 Query 302 ELM 304 L+ Sbjct 309 ALV 311 >gi|333918315|ref|YP_004491896.1| Porphobilinogen deaminase [Amycolicicoccus subflavus DQS3-9A1] gi|333480536|gb|AEF39096.1| Porphobilinogen deaminase [Amycolicicoccus subflavus DQS3-9A1] Length=304 Score = 377 bits (968), Expect = 1e-102, Method: Compositional matrix adjust. Identities = 195/291 (68%), Positives = 236/291 (82%), Gaps = 0/291 (0%) Query 14 TQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAMEAGLVDAAVHS 73 TQA TVRDA+IA G+ AEL I T GD S P+ +GVGVFT A+R+A+ A VD AVHS Sbjct 2 TQAGTVRDAIIAAGYPAELKIIRTAGDASAEPVEKIGVGVFTAAVRDALAAKEVDVAVHS 61 Query 74 YKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGL 133 YKDLPTA D RF +AA+PPR DPRDA+++RD LGEL GS+VGTS+PRR AQLRALGL Sbjct 62 YKDLPTAPDERFILAAVPPREDPRDALISRDSKVLGELAPGSVVGTSAPRRVAQLRALGL 121 Query 134 GLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGAL 193 GLEI PLRGN+DTR+ KV+SG+LDA+V+ARAGLAR+GR++++ E+L+PVQMLPAPAQGAL Sbjct 122 GLEIVPLRGNIDTRIGKVTSGELDAVVLARAGLARVGRVEEIAESLDPVQMLPAPAQGAL 181 Query 194 AVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIAEVVESIDEDGR 253 AVECRA + L A+LA+ DD D RA V AERALLA+LEAGC+APVGA+A+VVES+D+DG Sbjct 182 AVECRAEEPELAAILAKQDDPDARAMVNAERALLAELEAGCTAPVGALADVVESLDDDGV 241 Query 254 VFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGARELM 304 + EEL LR C AALDGS VIRAS G +A E+G +A EL +LGARELM Sbjct 242 IHEELFLRACAAALDGSRVIRASRTGRVDKAVEIGQELARELLDLGARELM 292 >gi|134103372|ref|YP_001109033.1| porphobilinogen deaminase [Saccharopolyspora erythraea NRRL 2338] gi|291004409|ref|ZP_06562382.1| porphobilinogen deaminase [Saccharopolyspora erythraea NRRL 2338] gi|133915995|emb|CAM06108.1| porphobilinogen deaminase [Saccharopolyspora erythraea NRRL 2338] Length=315 Score = 357 bits (916), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 194/300 (65%), Positives = 234/300 (78%), Gaps = 4/300 (1%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGS LA Q + V +AL G+ ELVT+ST GDRSMAPIA +GVGVFT+ALR+A Sbjct 5 LRIGTRGSALAMAQTSWVAEALEKAGYRTELVTVSTPGDRSMAPIAEIGVGVFTSALRDA 64 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VD AVHSYKDLPTA DPR ++AA+P R DPRDA+VARDGLTLGELP GS+VGT S Sbjct 65 LADGEVDVAVHSYKDLPTAPDPRLSLAAVPVREDPRDALVARDGLTLGELPPGSVVGTGS 124 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRA QL+ALGLGLE+R +RGN+DTR+ KV+ G+LDA+V+ARAGLAR+GRL +TETL+P Sbjct 125 PRRAGQLKALGLGLEVRDIRGNVDTRMRKVTDGELDAVVLARAGLARVGRLAGITETLDP 184 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAE-LDDADTRAAVTAERALLADLEAGCSAPVGA 240 +QMLPAPAQGALAVECR D +L LDD +R AV AERA+LA LEAGCSAPVGA Sbjct 185 LQMLPAPAQGALAVECRVDDVDTEHLLQSVLDDQASRVAVAAERAMLAALEAGCSAPVGA 244 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGS---DVIRASGIGSCGRARELGLSVAAELFE 297 +AEVVE +D DGRV + L +RG VA D S D++RAS G A +LG +AA+L + Sbjct 245 LAEVVEDLDADGRVAQRLFVRGVVAVDDASGRVDLLRASVTGETTAAEQLGRELAAQLLD 304 >gi|256380712|ref|YP_003104372.1| porphobilinogen deaminase [Actinosynnema mirum DSM 43827] gi|255925015|gb|ACU40526.1| porphobilinogen deaminase [Actinosynnema mirum DSM 43827] Length=313 Score = 354 bits (909), Expect = 9e-96, Method: Compositional matrix adjust. Identities = 191/298 (65%), Positives = 236/298 (80%), Gaps = 2/298 (0%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTRGS LA Q TV +AL A G E+VT+ST GDRS APIA +G+GVFT+ALR+A Sbjct 5 LRIGTRGSALALAQTGTVAEALRAAGAQVEIVTVSTPGDRSHAPIAEIGIGVFTSALRDA 64 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + G VD AVHSYKDLPTA D R ++AAIP R DPRDA+VARDGLTLGELP GS VGT S Sbjct 65 LAHGEVDVAVHSYKDLPTAPDTRLSLAAIPQREDPRDALVARDGLTLGELPPGSKVGTGS 124 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRA QL ALGLGLEI P+RGN+D+R+ +V G+LDA+V+ARAG++RLGR++++TE L+P Sbjct 125 PRRATQLAALGLGLEILPIRGNIDSRMARVFDGELDAVVLARAGISRLGRVENITEVLDP 184 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVL-AELDDADTRAAVTAERALLADLEAGCSAPVGA 240 +QMLPAPAQGALA+ECR D +L + LDD+ +RAAVTAERA+LA LEAGCSAPVGA Sbjct 185 IQMLPAPAQGALAIECRVDDVDTEHLLRSTLDDSASRAAVTAERAMLAALEAGCSAPVGA 244 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFEL 298 +A+VVE +D++G +SLRG VAA DG D++RAS G A ELG ++AAEL +L Sbjct 245 LADVVEDLDDEGAAVLRISLRGVVAAEDG-DLLRASATGDLTAAEELGRALAAELLDL 301 >gi|300782413|ref|YP_003762704.1| hydroxymethylbilane synthase [Amycolatopsis mediterranei U32] gi|299791927|gb|ADJ42302.1| hydroxymethylbilane synthase [Amycolatopsis mediterranei U32] gi|340523781|gb|AEK38986.1| porphobilinogen deaminase [Amycolatopsis mediterranei S699] Length=309 Score = 354 bits (908), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 192/302 (64%), Positives = 239/302 (80%), Gaps = 6/302 (1%) Query 4 IGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREAME 63 +GTRGS LA TQ TV DAL A G E+V ++T GD+S+APIA++GVGVFT+ALREA+ Sbjct 1 MGTRGSKLALTQTGTVADALRATGVEVEIVKVTTPGDKSLAPIATIGVGVFTSALREALL 60 Query 64 AGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSSPR 123 VD VHSYKDLPTA +P T+AA+PPR DPRDA++ARDGLTLGELP GS VGT + R Sbjct 61 RNEVDVIVHSYKDLPTAPEPGITLAAVPPREDPRDALIARDGLTLGELPPGSTVGTGAAR 120 Query 124 RAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQ 183 R AQLRALGLGLEI P+RGN+DTR+ KV+ G+LDA+V+ARAGLAR+G ++ +TETL+P+Q Sbjct 121 RTAQLRALGLGLEIVPIRGNIDTRMRKVTDGELDAVVLARAGLARVGLVEAITETLDPIQ 180 Query 184 MLPAPAQGALAVECRAGDSRLVAVL-AELDDADTRAAVTAERALLADLEAGCSAPVGAIA 242 MLPAPAQGALAVECR+ D L +L + LDD TRAAVTAERALLA LEAGCSAPVGA+A Sbjct 181 MLPAPAQGALAVECRSADVDLEHLLRSTLDDEGTRAAVTAERALLAALEAGCSAPVGALA 240 Query 243 EVVESIDEDGRVFEELSLRGCVAALDGS----DVIRASGIGSCGRARELGLSVAAELFEL 298 E+VE +D +G+V E +SLRG AA++G D++RA + +A +LG +AAEL +L Sbjct 241 EIVEDLDAEGKVVERISLRGT-AAIEGEEGAVDMVRAIALADKDQAAQLGKDLAAELLDL 299 Query 299 GA 300 GA Sbjct 300 GA 301 >gi|302523839|ref|ZP_07276181.1| porphobilinogen deaminase [Streptomyces sp. AA4] gi|302432734|gb|EFL04550.1| porphobilinogen deaminase [Streptomyces sp. AA4] Length=315 Score = 347 bits (890), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 188/299 (63%), Positives = 233/299 (78%), Gaps = 6/299 (2%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 VIRIGTRGS LA Q V D + A G E+VT++T GD S API+ +GVGVFT+ALRE Sbjct 4 VIRIGTRGSKLALAQTGIVADTIRATGAEVEIVTVTTPGDLSSAPISQIGVGVFTSALRE 63 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ +D AVHSYKDLPTA + +AA+PPR DPRDA++ARDGLTLGELP G+ VGT Sbjct 64 ALLRNEIDVAVHSYKDLPTAPEAGLVLAAVPPREDPRDALIARDGLTLGELPPGAKVGTG 123 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 + RR AQLRALGLGLEI P+RGN+DTR+ KV+ G+LDA+V+ARAGLAR+GR+D++TETL+ Sbjct 124 AARRMAQLRALGLGLEIVPIRGNIDTRMRKVTDGELDAVVLARAGLARVGRVDEITETLD 183 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAE-LDDADTRAAVTAERALLADLEAGCSAPVG 239 P+QMLPAPAQGALA+ECRA D + +LA +DD TR AVTAERALLA LEAGCSAPVG Sbjct 184 PIQMLPAPAQGALALECRAADVDIEHLLASAVDDETTRVAVTAERALLAALEAGCSAPVG 243 Query 240 AIAEVVESIDEDGRVFEELSLRGCVAALDGS----DVIRASGIGSCGRARELGLSVAAE 294 A+AE+VE +D++G V E +SLRG AA++G D++RAS I G A +LG +AAE Sbjct 244 ALAEIVEDLDDEGAVVERISLRGT-AAVEGENGGVDMVRASAIAGIGEAEKLGRELAAE 301 >gi|284992946|ref|YP_003411500.1| porphobilinogen deaminase [Geodermatophilus obscurus DSM 43160] gi|284066191|gb|ADB77129.1| porphobilinogen deaminase [Geodermatophilus obscurus DSM 43160] Length=312 Score = 343 bits (880), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 198/309 (65%), Positives = 226/309 (74%), Gaps = 7/309 (2%) Query 2 IRIGTRGSLLATTQAATVRDALIAG-GHSAELVTISTEGDRSMAPIASLG-VGVFTTALR 59 +R+GTR S LATTQ+ V DA+ A G ELV ISTEGDRS IA LG GVF TA+R Sbjct 9 LRLGTRASQLATTQSQAVADAITAASGVPVELVHISTEGDRSSVAIAQLGGTGVFVTAIR 68 Query 60 EAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGT 119 +A+ G VD AVHSYKDLPT +P T+AA+PPR DPRDA+VARDGLTLGELP G+ VGT Sbjct 69 QALLEGTVDVAVHSYKDLPTLPEPGLTIAAVPPREDPRDALVARDGLTLGELPAGARVGT 128 Query 120 SSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETL 179 +PRR AQLRALGLGLE+ P+RGN+DTR+ +V GDLDA+V+ARAGL+RLGRL VTETL Sbjct 129 GAPRRVAQLRALGLGLEVVPIRGNVDTRMARVVPGDLDAVVLARAGLSRLGRLSAVTETL 188 Query 180 EPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVG 239 +P+Q+LPAPAQGALAVECR D R +LA LDDA TRA V AER LA LEAGCSAPV Sbjct 189 DPLQVLPAPAQGALAVECRGNDERTRQLLAALDDAATRACVVAERTTLAALEAGCSAPVA 248 Query 240 AIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELG 299 A AEV E EDG EL LR V ALDGSD +R S G A LG +AAEL + G Sbjct 249 AYAEVAEG--EDG---PELFLRASVTALDGSDGVRGSITGPPPEAERLGRELAAELLDRG 303 Query 300 ARELMWGVR 308 A ELM R Sbjct 304 AAELMAASR 312 >gi|311744366|ref|ZP_07718168.1| hydroxymethylbilane synthase [Aeromicrobium marinum DSM 15272] gi|311312332|gb|EFQ82247.1| hydroxymethylbilane synthase [Aeromicrobium marinum DSM 15272] Length=311 Score = 333 bits (855), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 189/305 (62%), Positives = 225/305 (74%), Gaps = 7/305 (2%) Query 2 IRIGTRGSLLATTQAATVRDALI-AGGHSAELVTISTEGDRSMAPIASLG-VGVFTTALR 59 +R+GTR S+LA TQ+ V D + G + ELVTISTEGDRS P+A +G GVF ALR Sbjct 8 LRLGTRASVLARTQSGHVADRITEVSGRAVELVTISTEGDRSTGPLAEMGGQGVFVAALR 67 Query 60 EAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGT 119 EA+ AG VD AVHS KDLPTA DPR +AA+PPR D RD VVARDGLTLGELP G+ +GT Sbjct 68 EAVAAGHVDLAVHSLKDLPTAPDPRLALAAVPPREDVRDVVVARDGLTLGELPQGARIGT 127 Query 120 SSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETL 179 SPRR AQ+ ALGLG+EI P+RGN+DTR+ KV+SG++DA+V+ARAGL RLGR D+ TE L Sbjct 128 GSPRREAQINALGLGVEIVPIRGNVDTRIGKVASGEVDAVVLARAGLLRLGRADEATEVL 187 Query 180 EPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVG 239 +P+Q+LPAP QGALAVECRAGD L+ +LA LDDADTRAAVTAER+LLA LEAGCSAPVG Sbjct 188 DPIQVLPAPGQGALAVECRAGDDELIGLLAALDDADTRAAVTAERSLLAALEAGCSAPVG 247 Query 240 AIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELG 299 A+AEV D D EL +R VA GS IR S G A +G +AAE+ G Sbjct 248 ALAEVAWGDDGD-----ELWIRAVVADPSGSPTIRLSATGLPAEAAAVGERLAAEMLADG 302 Query 300 ARELM 304 A +M Sbjct 303 ADRIM 307 >gi|257054363|ref|YP_003132195.1| porphobilinogen deaminase [Saccharomonospora viridis DSM 43017] gi|256584235|gb|ACU95368.1| hydroxymethylbilane synthase [Saccharomonospora viridis DSM 43017] Length=316 Score = 331 bits (849), Expect = 8e-89, Method: Compositional matrix adjust. Identities = 181/303 (60%), Positives = 222/303 (74%), Gaps = 4/303 (1%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 +RIGTR S LA +Q T+ L G ELV +ST GDRS APIA +GVGVFT+ALREA Sbjct 9 LRIGTRASNLAMSQTRTIAKMLEEAGQKVELVPVSTPGDRSSAPIAEIGVGVFTSALREA 68 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 + A VD AVHSYKDLPTA P +AA+ R DPRD +++RDGLTLGELP G+ VGT S Sbjct 69 LLANEVDVAVHSYKDLPTAPQPGIVLAAVSKREDPRDVLISRDGLTLGELPPGAKVGTGS 128 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRR QLRALGLGLEI P+RGN+DTR+ KV+SG+LDAIV+A+AGL R+G+LD +TE ++P Sbjct 129 PRRMTQLRALGLGLEIVPIRGNIDTRIAKVTSGELDAIVLAKAGLTRVGKLDLITEVIDP 188 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVLAELDDAD-TRAAVTAERALLADLEAGCSAPVGA 240 +Q+LPAPAQGALAVE R D +L + D + TR AV AERA+LA L+AGCSAPVGA Sbjct 189 MQILPAPAQGALAVETRVDDVDTEHLLRSIVDHEATRVAVAAERAVLATLQAGCSAPVGA 248 Query 241 IAEVVESIDEDGRVFEELSLRGCVAAL---DGSDVIRASGIGSCGRARELGLSVAAELFE 297 +AEVVE +D +G V E LSLRG A D ++RASG+ A LG +VA+EL + Sbjct 249 LAEVVEDLDSEGAVVERLSLRGVAATATEGDSVQILRASGVADKHEADRLGRTVASELLD 308 Query 298 LGA 300 LGA Sbjct 309 LGA 311 >gi|331699360|ref|YP_004335599.1| Porphobilinogen deaminase [Pseudonocardia dioxanivorans CB1190] gi|326954049|gb|AEA27746.1| Porphobilinogen deaminase [Pseudonocardia dioxanivorans CB1190] Length=327 Score = 323 bits (827), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 188/309 (61%), Positives = 232/309 (76%), Gaps = 7/309 (2%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 V+RIGTR S LA Q+ + D L A GH+ ELV +ST GDRS AP+A LGVGVF +A+R+ Sbjct 4 VLRIGTRPSALAMAQSGQIADRLRAAGHTVELVPVSTVGDRSGAPVAELGVGVFVSAVRD 63 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ +G VD A+HSYKDLPTA DPR T+ A+P R DPRDA+VARDG LGELP GS VGT Sbjct 64 AVASGEVDVAIHSYKDLPTAPDPRLTLVAVPGREDPRDALVARDGKVLGELPAGSRVGTG 123 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 S RR AQL+ALGLGLE+ P+RGN+DTR+ KV+SG+LD ++VA AGL RLGR+ + TE LE Sbjct 124 SARRTAQLQALGLGLEVVPIRGNVDTRIGKVTSGELDGVIVAAAGLRRLGRIGEATELLE 183 Query 181 PVQMLPAPAQGALAVECRAG------DSRLVAVLAELDDADTRAAVTAERALLADLEAGC 234 PVQMLPAPAQGALAVECRAG +A+ A LDD RAAVTAERA+LA LEAGC Sbjct 184 PVQMLPAPAQGALAVECRAGVPGSTEHGLALALTALLDDPAARAAVTAERAVLASLEAGC 243 Query 235 SAPVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAE 294 +AP+GA+A+VV +D+ GRV + LSLR V DG+ ++RAS G A +LG ++AAE Sbjct 244 TAPIGALADVVSDLDDAGRVVDRLSLRAVVGTADGA-LLRASVTGDIDDAEKLGAALAAE 302 Query 295 LFELGAREL 303 L ++GA L Sbjct 303 LLDMGADTL 311 >gi|309810452|ref|ZP_07704278.1| hydroxymethylbilane synthase [Dermacoccus sp. Ellin185] gi|308435584|gb|EFP59390.1| hydroxymethylbilane synthase [Dermacoccus sp. Ellin185] Length=327 Score = 317 bits (811), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 176/300 (59%), Positives = 224/300 (75%), Gaps = 5/300 (1%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLG-VGVFTTALRE 60 IR+GTR S LA TQ+ V + L A GH+ E+V I+TEGD + A +A +G GVF A+R Sbjct 11 IRLGTRRSHLAMTQSTWVAEQLRAHGHAVEIVEITTEGDVNRASLAQMGGTGVFAAAIRR 70 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ VD AVHS KDLP A +P +A IP R DPRDA+VARDGLTLGELP G++VGT Sbjct 71 ALLEDEVDMAVHSLKDLPVAPEPGLVIAGIPVREDPRDALVARDGLTLGELPAGAVVGTG 130 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRRAAQL+ALGLG EIR +RGN+DTR+ V+SG+LD +++ARAGLAR+ R ++ET++ Sbjct 131 SPRRAAQLQALGLGFEIRDIRGNIDTRMGYVTSGELDGVILARAGLARVERTGAISETID 190 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 P+QMLPAP QGAL +ECR GD+R++A LAELDDADTRAAVTAERA+L LEAGC+APVGA Sbjct 191 PLQMLPAPGQGALGLECREGDARVIAALAELDDADTRAAVTAERAVLGALEAGCAAPVGA 250 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 +AE+VE + DG + E+SLR V A DGS +R S +GS +G ++A L + GA Sbjct 251 LAEIVE--EPDGSL--EISLRAFVGAPDGSFELRRSDVGSYDNPAAVGEALARTLLDDGA 306 >gi|302870086|ref|YP_003838723.1| porphobilinogen deaminase [Micromonospora aurantiaca ATCC 27029] gi|315503637|ref|YP_004082524.1| porphobilinogen deaminase [Micromonospora sp. L5] gi|302572945|gb|ADL49147.1| porphobilinogen deaminase [Micromonospora aurantiaca ATCC 27029] gi|315410256|gb|ADU08373.1| porphobilinogen deaminase [Micromonospora sp. L5] Length=328 Score = 315 bits (806), Expect = 7e-84, Method: Compositional matrix adjust. Identities = 180/307 (59%), Positives = 223/307 (73%), Gaps = 4/307 (1%) Query 2 IRIGTRGSLLATTQAATVRDALIAG-GHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +R+GTRGS LA Q+ V +AL A G ELV + T GDRS AP+ LGVGVF +ALR+ Sbjct 5 LRLGTRGSALAMAQSGHVAEALTAATGRPVELVEVVTAGDRSTAPVQRLGVGVFVSALRD 64 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ AG +D AVHSYKDLPTAA P VAA+PPR DPRDA+VA +G TL ELP G+ VGT Sbjct 65 ALTAGEIDFAVHSYKDLPTAAAPGLHVAAVPPRQDPRDALVATNGRTLAELPPGARVGTG 124 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKV--SSGDLDAIVVARAGLARLGRLDDVTET 178 + RR AQL ALG+ LE+ P+RGN+DTRL +V DLDA+V+ARAGL R+GR D +TET Sbjct 125 ALRRIAQLHALGMQLEVSPIRGNVDTRLGRVLGPDADLDAVVLARAGLNRIGRADVITET 184 Query 179 LEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPV 238 L+P+ MLPAPAQGALAVECRA D ++ +LA LD A +RAA+TAERALLA LEAGCSAPV Sbjct 185 LDPMLMLPAPAQGALAVECRADDQDVIELLALLDHAPSRAAITAERALLATLEAGCSAPV 244 Query 239 GAIAEVVESIDED-GRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFE 297 A A + E D G V +E+ LRG V + DG+ +R S G+ A E+G ++AAEL E Sbjct 245 AAYAVLAEGEPTDEGDVNQEIYLRGAVISPDGTRDLRLSRTGTPADAAEIGKALAAELLE 304 Query 298 LGARELM 304 LGA ++ Sbjct 305 LGADSIL 311 >gi|238061239|ref|ZP_04605948.1| porphobilinogen deaminase [Micromonospora sp. ATCC 39149] gi|237883050|gb|EEP71878.1| porphobilinogen deaminase [Micromonospora sp. ATCC 39149] Length=322 Score = 313 bits (801), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 183/306 (60%), Positives = 222/306 (73%), Gaps = 8/306 (2%) Query 2 IRIGTRGSLLATTQAATVRDALIAG-GHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +R+GTRGS LA Q+ V AL A G ELV + T GDRS AP+ LGVGVF +ALR+ Sbjct 5 LRLGTRGSALAIAQSGQVAAALTAATGREVELVEVVTAGDRSSAPVHRLGVGVFVSALRD 64 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ A +D AVHSYKDLPTAA +AA+PPR DPRDA+VA+ G TL ELP G++VGT Sbjct 65 ALVARTIDLAVHSYKDLPTAAASGLHIAAVPPRQDPRDALVAKGGRTLAELPPGAVVGTG 124 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKV--SSGDLDAIVVARAGLARLGRLDDVTET 178 + RR AQL ALGL LE+ P+RGN+DTRL +V DLDA+V+ARAGLARLGR D +TET Sbjct 125 ALRRIAQLHALGLQLEVTPIRGNVDTRLARVLGPDADLDAVVLARAGLARLGRTDVITET 184 Query 179 LEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPV 238 L+P+ MLPAPAQGALAVECRA D LV +LA LD A +RAAVTAERALLA LEAGCSAPV Sbjct 185 LDPMLMLPAPAQGALAVECRADDPDLVELLAVLDHAPSRAAVTAERALLATLEAGCSAPV 244 Query 239 GAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFEL 298 A AE+ E G V +E+ LRG V + DG+ +R S G+ A E+G ++AAEL EL Sbjct 245 AAYAELAE-----GDVGDEIYLRGAVISSDGTRDLRLSRTGTPADAAEIGKALAAELLEL 299 Query 299 GARELM 304 GA ++ Sbjct 300 GADSIL 305 >gi|317123819|ref|YP_004097931.1| hydroxymethylbilane synthase [Intrasporangium calvum DSM 43043] gi|315587907|gb|ADU47204.1| hydroxymethylbilane synthase [Intrasporangium calvum DSM 43043] Length=316 Score = 312 bits (800), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 182/303 (61%), Positives = 219/303 (73%), Gaps = 6/303 (1%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLG-VGVFTTALRE 60 +R+GTR S LATTQ+ V D L A GH ELV I+TEGD S + ++G GVF A+R+ Sbjct 4 LRLGTRRSALATTQSGWVADQLRAAGHDVELVEITTEGDVSGGLLTAIGGTGVFAAAIRK 63 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ G VD AVHS KDLPTA +P VAA+P R D RD +VARDGLTLGELP+GS+VGT Sbjct 64 ALTDGRVDVAVHSLKDLPTAPEPGLVVAAVPAREDSRDVLVARDGLTLGELPIGSVVGTG 123 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLE 180 SPRR AQL ALGLGLEIRP+RGN+DTRL VSSG++DA+++ARAGLARLGRLD VTE L+ Sbjct 124 SPRRTAQLAALGLGLEIRPIRGNVDTRLRLVSSGEVDAVILARAGLARLGRLDVVTEVLD 183 Query 181 PVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGA 240 P+Q+LPAP QGALAVECRA ++ ++ L+DADTRA++TAERALLA LEAGC+APVGA Sbjct 184 PIQVLPAPGQGALAVECRADRPDVLEAVSVLEDADTRASITAERALLAALEAGCTAPVGA 243 Query 241 IAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFELGA 300 +AEVV DG ELSLR DG +R S G LG +A L E GA Sbjct 244 LAEVV-----DGEEGLELSLRAFAGTEDGRIDLRRSLTGRYDDPESLGRRLAQILLEDGA 298 Query 301 REL 303 +L Sbjct 299 ADL 301 >gi|145592923|ref|YP_001157220.1| porphobilinogen deaminase [Salinispora tropica CNB-440] gi|145302260|gb|ABP52842.1| hydroxymethylbilane synthase [Salinispora tropica CNB-440] Length=322 Score = 311 bits (798), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 181/311 (59%), Positives = 222/311 (72%), Gaps = 8/311 (2%) Query 2 IRIGTRGSLLATTQAATVRDALIAG-GHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +R+GTRGS LA Q+ V +AL A G ELV + T GDRS AP+ LGVGVF +ALR+ Sbjct 5 LRLGTRGSALAMAQSGQVAEALTAATGTPVELVEVVTTGDRSTAPVHQLGVGVFVSALRD 64 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ AG +D AVHSYKDLPTAA P VAA+PPR DPRDA+VA G TL ELP G+ VGT Sbjct 65 ALAAGAIDFAVHSYKDLPTAAAPGLYVAAVPPRQDPRDALVATGGRTLAELPPGARVGTG 124 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKV--SSGDLDAIVVARAGLARLGRLDDVTET 178 + RR AQL ALGL LE++P+RGN+ TRL +V DLDA+V+ARAGLARL R D +TET Sbjct 125 ALRRIAQLHALGLQLEVQPIRGNVGTRLARVLGPEADLDAVVLARAGLARLDRTDTITET 184 Query 179 LEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPV 238 L+P+ MLPAPAQGALAVECR+ DS LV +LA LD A +RA V AERALLA LEAGCSAPV Sbjct 185 LDPMLMLPAPAQGALAVECRSDDSALVELLAVLDHAPSRATVVAERALLATLEAGCSAPV 244 Query 239 GAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFEL 298 A AE+ E G V EE+ LRG V + DG+ +R S G+ A E+G ++A +L +L Sbjct 245 AAYAELAE-----GDVGEEIYLRGAVISPDGTRDLRLSRTGTPADAVEIGKALATDLLDL 299 Query 299 GARELMWGVRH 309 GA ++ R+ Sbjct 300 GADSILGQQRN 310 >gi|159036094|ref|YP_001535347.1| porphobilinogen deaminase [Salinispora arenicola CNS-205] gi|157914929|gb|ABV96356.1| porphobilinogen deaminase [Salinispora arenicola CNS-205] Length=322 Score = 310 bits (793), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 181/311 (59%), Positives = 222/311 (72%), Gaps = 8/311 (2%) Query 2 IRIGTRGSLLATTQAATVRDALIAG-GHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +R+GTRGS LA Q+ V AL A G+ ELV + T GDRS AP+ LGVGVF +ALR+ Sbjct 5 LRLGTRGSALAMAQSGQVAQALTAATGNPVELVEVVTAGDRSAAPVHRLGVGVFVSALRD 64 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ A +D AVHS+KDLPTAA P VAA+PPR DPRDA+VAR G TL ELP G+ VGT Sbjct 65 ALTARTIDFAVHSFKDLPTAAAPGLHVAAVPPRQDPRDALVARAGRTLAELPPGARVGTG 124 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKV--SSGDLDAIVVARAGLARLGRLDDVTET 178 + RR AQL ALGL L+++P+RGN+ TRL +V DLDA+V+ARAGLARL R D +TET Sbjct 125 ALRRIAQLHALGLQLDVQPIRGNVGTRLARVLGPEADLDAVVLARAGLARLDRTDTITET 184 Query 179 LEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPV 238 L+P+ MLPAPAQGALAVECR+ DS LV +LA LD A +RA V AERALLA LEAGCSAPV Sbjct 185 LDPMLMLPAPAQGALAVECRSDDSDLVELLAVLDHAPSRATVVAERALLATLEAGCSAPV 244 Query 239 GAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFEL 298 A AE+ E G V EE+ LRG V + DG+ +R S G+ A E+G ++AA+L EL Sbjct 245 AAYAELAE-----GDVGEEIYLRGAVISPDGTRDLRLSRTGTPADAVEIGKALAADLLEL 299 Query 299 GARELMWGVRH 309 GA ++ H Sbjct 300 GADSILGQEGH 310 >gi|84494981|ref|ZP_00994100.1| porphobilinogen deaminase [Janibacter sp. HTCC2649] gi|84384474|gb|EAQ00354.1| porphobilinogen deaminase [Janibacter sp. HTCC2649] Length=329 Score = 306 bits (784), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 188/305 (62%), Positives = 226/305 (75%), Gaps = 7/305 (2%) Query 1 VIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRS-MAPIASLG-VGVFTTAL 58 +R+GTR S LATTQ+ V D L A GH ELV I+T+GDR P+A++G GVF +AL Sbjct 2 TLRLGTRRSALATTQSGWVADQLRALGHDVELVEITTDGDRDRTTPLATMGGTGVFVSAL 61 Query 59 REAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVG 118 R+A+ AG VD AVHS KDLPT + VAAIPPR DPRDA+VARDGLTLGELP GS VG Sbjct 62 RDALRAGTVDLAVHSLKDLPTTPEDDLAVAAIPPREDPRDALVARDGLTLGELPSGSTVG 121 Query 119 TSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTET 178 T SPRR AQL ALGLGL+IR LRGN+DTRL +V+SGDLDA+V+A+AGLARLGR VTE Sbjct 122 TGSPRRRAQLEALGLGLDIRELRGNVDTRLGRVTSGDLDAVVLAQAGLARLGRTSVVTEV 181 Query 179 LEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPV 238 ++P+QMLPAP QGALAVE RA D+ +A LDDADTRA V AERA+L++LE GCSAPV Sbjct 182 IDPIQMLPAPGQGALAVEVRADDAATRDAVAALDDADTRACVDAERAVLSELEVGCSAPV 241 Query 239 GAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELFEL 298 GA+AE+V + +DG +ELSLR VA+ DG+ IR S GS A +G +A L E Sbjct 242 GALAEIV--LGDDG---DELSLRAVVASPDGTGDIRRSATGSPTDADGIGRRLARLLLED 296 Query 299 GAREL 303 GA +L Sbjct 297 GAADL 301 >gi|325001831|ref|ZP_08122943.1| porphobilinogen deaminase [Pseudonocardia sp. P1] Length=322 Score = 300 bits (767), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 178/305 (59%), Positives = 224/305 (74%), Gaps = 4/305 (1%) Query 2 IRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGDRSMAPIASLGVGVFTTALREA 61 ++IGTR S LA Q+ T+ D L A GH +ELVT+ST GDRSMAP+ LGVGVF +ALR+A Sbjct 4 LKIGTRPSKLAVAQSTTIADRLTAAGHPSELVTVSTSGDRSMAPVTQLGVGVFVSALRDA 63 Query 62 MEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTSS 121 ++AG +D AVHS+KDLPTA +AA+P R DPRDA+V G LGEL G+ VGT S Sbjct 64 LDAGDIDVAVHSFKDLPTAQPEHLRIAAVPGREDPRDALVT-GGRVLGELGRGARVGTGS 122 Query 122 PRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEP 181 PRRAAQL ALG GLE+ P+RGN+DTR+ KV SG+LDA+VVA AGL RLGR+++ E ++P Sbjct 123 PRRAAQLYALGQGLEVVPIRGNVDTRIGKVRSGELDAVVVAAAGLRRLGRIEEADELIDP 182 Query 182 VQMLPAPAQGALAVECRAGDSRLVAVL-AELDDADTRAAVTAERALLADLEAGCSAPVGA 240 +QMLPAPAQGALA+ECR D+ L VL + LDD RAAV AERA+LA LEAGC+APVGA Sbjct 183 LQMLPAPAQGALAIECRETDTGLADVLRSVLDDPGVRAAVAAERAVLATLEAGCTAPVGA 242 Query 241 IAEVVESIDEDGRVFEELSLRGC--VAALDGSDVIRASGIGSCGRARELGLSVAAELFEL 298 +A+VV +D+DGR + LSLR V + DV+RAS G A +LG ++A EL +L Sbjct 243 LADVVSDLDDDGRAVDRLSLRAVTGVGDITEGDVLRASVTGEMDAAEKLGATLAHELLDL 302 Query 299 GAREL 303 G +L Sbjct 303 GGEDL 307 >gi|119714759|ref|YP_921724.1| porphobilinogen deaminase [Nocardioides sp. JS614] gi|119535420|gb|ABL80037.1| hydroxymethylbilane synthase [Nocardioides sp. JS614] Length=314 Score = 294 bits (752), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 177/307 (58%), Positives = 212/307 (70%), Gaps = 10/307 (3%) Query 2 IRIGTRGSLLATTQAATVRDAL-IAGGHSAELVTISTEGDRSMAPIASL----GVGVFTT 56 +R+GTR S+LATTQ+ V D L A G ELVT+STEGDR+ A L GVF Sbjct 5 LRVGTRASVLATTQSGLVADQLREALGREVELVTVSTEGDRTQAAGIPLQGGSATGVFVA 64 Query 57 ALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSL 116 ALR+A+ G VD AVHS KDLPT T+AA+P R DPRD VVARDGLTLGELPVGS Sbjct 65 ALRDALLRGEVDVAVHSLKDLPTYPTEGITLAAVPVREDPRDVVVARDGLTLGELPVGSR 124 Query 117 VGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVT 176 VGT SPRR AQL ALGLGLE+ +RGN+DTR+ KV SG+ DA+++ARAGLAR+GRL+ VT Sbjct 125 VGTGSPRRVAQLHALGLGLEVVGIRGNVDTRIGKVRSGECDAVILARAGLARIGRLEAVT 184 Query 177 ETLEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSA 236 E L+P+QMLPAP QGALAVECR D V A LDD RAAVTAERA+LA LE GCSA Sbjct 185 EVLDPLQMLPAPGQGALAVECRTDDPLAAQVAAALDDPRVRAAVTAERAVLATLEGGCSA 244 Query 237 PVGAIAEVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAELF 296 P+GA+AE+VE EDG +EL +R + DG+ +R S GS A +G + ++ Sbjct 245 PIGALAEIVEG--EDG---DELWVRSVALSPDGALSVRRSASGSPSDAAGVGTRLGEQML 299 Query 297 ELGAREL 303 GA L Sbjct 300 ADGADRL 306 >gi|330470294|ref|YP_004408037.1| porphobilinogen deaminase [Verrucosispora maris AB-18-032] gi|328813265|gb|AEB47437.1| porphobilinogen deaminase [Verrucosispora maris AB-18-032] Length=336 Score = 289 bits (740), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 177/315 (57%), Positives = 218/315 (70%), Gaps = 7/315 (2%) Query 2 IRIGTRGSLLATTQAATVRDALIA-GGHSAELVTISTEGDRSMAPIASLGVGVFTTALRE 60 +R+GTRGS LA Q+ V +AL A G ELV + T GDRS AP+ LGVGVF +ALR+ Sbjct 10 LRLGTRGSKLAMAQSGHVAEALTARTGRPVELVEVITAGDRSSAPVHRLGVGVFVSALRD 69 Query 61 AMEAGLVDAAVHSYKDLPTAADPRFTVAAIPPRNDPRDAVVARDGLTLGELPVGSLVGTS 120 A+ A +D AVHSYKDLPTA +AA+PPR DPRDA+VARDG TL EL G+ +GT Sbjct 70 ALVAREIDFAVHSYKDLPTAMPAGLHIAAVPPREDPRDALVARDGRTLAELAPGASIGTG 129 Query 121 SPRRAAQLRALGLGLEIRPLRGNLDTRLNKV--SSGDLDAIVVARAGLARLGRLDDVTET 178 + RR AQL ALG+ L + P+RGN+DTRL +V DLDAIV+ARAGLAR+GRLD +TET Sbjct 130 ALRRIAQLHALGMQLSVSPIRGNIDTRLARVLGPDADLDAIVLARAGLARIGRLDVITET 189 Query 179 LEPVQMLPAPAQGALAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPV 238 L+P+ MLPAPAQGALAVECR D +V +L LD A +RA VTAERA+LA LEAGCSAPV Sbjct 190 LDPMLMLPAPAQGALAVECRVDDPEMVELLGTLDHAASRATVTAERAMLATLEAGCSAPV 249 Query 239 GAIAEVVESIDE----DGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVAAE 294 A A V E +G V +E+ LRG V + DGS IR S G+ A E+G ++A E Sbjct 250 AAYAVVAEGEPTGSGVEGDVVQEIYLRGAVISPDGSRDIRLSRTGTLADAAEIGKALATE 309 Query 295 LFELGARELMWGVRH 309 L +LGA ++ H Sbjct 310 LLDLGADSILGPQGH 324 Lambda K H 0.318 0.134 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 527502211620 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40