BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0511 Length=565 Score E Sequences producing significant alignments: (Bits) Value gi|31791693|ref|NP_854186.1| uroporphyrin-III C-methyltransferas... 1120 0.0 gi|15839904|ref|NP_334941.1| uroporphyrin-III C-methyltransferas... 1120 0.0 gi|308231571|ref|ZP_07412949.2| uroporphyrin-III C-methyltransfe... 1089 0.0 gi|297729975|ref|ZP_06959093.1| putative uroporphyrin-III C-meth... 1059 0.0 gi|340625539|ref|YP_004743991.1| putative uroporphyrin-III C-met... 1047 0.0 gi|289568435|ref|ZP_06448662.1| uroporphyrin-III C-methyltransfe... 1044 0.0 gi|41410102|ref|NP_962938.1| hypothetical protein MAP4004 [Mycob... 986 0.0 gi|336460522|gb|EGO39417.1| uroporphyrinogen-III synthase [Mycob... 986 0.0 gi|342858984|ref|ZP_08715638.1| uroporphyrin-III C-methyltransfe... 979 0.0 gi|183980869|ref|YP_001849160.1| uroporphyrin-III C-methyltransf... 966 0.0 gi|254777075|ref|ZP_05218591.1| hypothetical protein MaviaA2_207... 963 0.0 gi|118619688|ref|YP_908020.1| uroporphyrin-III C-methyltransfera... 962 0.0 gi|254821057|ref|ZP_05226058.1| hypothetical protein MintA_14067... 955 0.0 gi|240171919|ref|ZP_04750578.1| uroporphyrin-III C-methyltransfe... 952 0.0 gi|118465929|ref|YP_883767.1| uroporphyrinogen-III synthase [Myc... 936 0.0 gi|15828302|ref|NP_302565.1| uroporphyrin-III C-methyltransferas... 915 0.0 gi|296168170|ref|ZP_06850191.1| uroporphyrin-III C-methyltransfe... 908 0.0 gi|333989146|ref|YP_004521760.1| uroporphyrin-III C-methyltransf... 886 0.0 gi|167967418|ref|ZP_02549695.1| uroporphyrin-III C-methyltransfe... 879 0.0 gi|108797658|ref|YP_637855.1| uroporphyrinogen-III synthase / ur... 875 0.0 gi|126433282|ref|YP_001068973.1| uroporphyrinogen-III synthase /... 874 0.0 gi|120401861|ref|YP_951690.1| uroporphyrinogen III synthase HEM4... 863 0.0 gi|118473053|ref|YP_885357.1| uroporphyrinogen-III synthase [Myc... 851 0.0 gi|145220671|ref|YP_001131349.1| uroporphyrinogen III synthase H... 842 0.0 gi|169631070|ref|YP_001704719.1| uroporphyrin-III C-methyltransf... 810 0.0 gi|262201011|ref|YP_003272219.1| uroporphyrin-III C/tetrapyrrole... 766 0.0 gi|312141092|ref|YP_004008428.1| uroporphyrinogen-iii synthase h... 761 0.0 gi|54027142|ref|YP_121384.1| putative uroporphyrin-III C-methylt... 761 0.0 gi|226305132|ref|YP_002765090.1| uroporphyrinogen-III methyltran... 758 0.0 gi|343925964|ref|ZP_08765479.1| uroporphyrinogen-III methyltrans... 756 0.0 gi|111019044|ref|YP_702016.1| uroporphiryn-III C-methyltransfera... 753 0.0 gi|226361137|ref|YP_002778915.1| uroporphyrinogen-III methyltran... 752 0.0 gi|326383044|ref|ZP_08204733.1| uroporphyrin-III C-methyltransfe... 741 0.0 gi|296138402|ref|YP_003645645.1| uroporphyrin-III C/tetrapyrrole... 735 0.0 gi|467061|gb|AAA17245.1| cysG [Mycobacterium leprae] 724 0.0 gi|333918316|ref|YP_004491897.1| putative uroporphiryn-III C-met... 703 0.0 gi|256380711|ref|YP_003104371.1| uroporphyrin-III C/tetrapyrrole... 701 0.0 gi|134103371|ref|YP_001109032.1| uroporphyrinogen III synthase/m... 696 0.0 gi|257054364|ref|YP_003132196.1| uroporphyrinogen-III synthase /... 679 0.0 gi|296394052|ref|YP_003658936.1| uroporphyrin-III C/tetrapyrrole... 672 0.0 gi|319949782|ref|ZP_08023806.1| uroporphyrin-III C-methyltransfe... 669 0.0 gi|302523840|ref|ZP_07276182.1| uroporphyrinogen III synthase/me... 669 0.0 gi|300782414|ref|YP_003762705.1| uroporphyrinogen-III synthase [... 664 0.0 gi|291004410|ref|ZP_06562383.1| uroporphyrinogen III synthase/me... 656 0.0 gi|331699359|ref|YP_004335598.1| uroporphyrinogen-III C-methyltr... 649 0.0 gi|325001830|ref|ZP_08122942.1| uroporphyrin-III C-methyltransfe... 620 2e-175 gi|258651163|ref|YP_003200319.1| uroporphyrin-III C/tetrapyrrole... 604 2e-170 gi|284992945|ref|YP_003411499.1| Uroporphyrinogen III synthase H... 561 7e-158 gi|302870085|ref|YP_003838722.1| Uroporphyrinogen III synthase H... 558 1e-156 gi|330470293|ref|YP_004408036.1| uroporphyrinogen iii synthase h... 558 1e-156 >gi|31791693|ref|NP_854186.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium bovis AF2122/97] gi|57116747|ref|YP_177733.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium tuberculosis H37Rv] gi|121636429|ref|YP_976652.1| putative uroporphyrin-III c-methyltransferase hemD [Mycobacterium bovis BCG str. Pasteur 1173P2] 48 more sequence titles Length=565 Score = 1120 bits (2898), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/565 (100%), Positives = 565/565 (100%), Gaps = 0/565 (0%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV Sbjct 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV Sbjct 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR Sbjct 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE Sbjct 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV Sbjct 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA Sbjct 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP Sbjct 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG Sbjct 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD Sbjct 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSRRR Sbjct 541 ALAEHAARLRAEGALPPPRKKSRRR 565 >gi|15839904|ref|NP_334941.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Mycobacterium tuberculosis CDC1551] gi|253797443|ref|YP_003030444.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis KZN 1435] gi|254230858|ref|ZP_04924185.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis C] 14 more sequence titles Length=568 Score = 1120 bits (2897), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/565 (100%), Positives = 565/565 (100%), Gaps = 0/565 (0%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV Sbjct 4 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 63 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV Sbjct 64 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 123 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR Sbjct 124 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 183 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE Sbjct 184 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 243 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV Sbjct 244 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 303 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA Sbjct 304 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 363 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP Sbjct 364 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 423 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG Sbjct 424 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 483 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD Sbjct 484 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 543 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSRRR Sbjct 544 ALAEHAARLRAEGALPPPRKKSRRR 568 >gi|308231571|ref|ZP_07412949.2| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis SUMu001] gi|308395587|ref|ZP_07492112.2| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis SUMu012] gi|308216829|gb|EFO76228.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis SUMu001] gi|308367293|gb|EFP56144.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis SUMu012] Length=551 Score = 1089 bits (2816), Expect = 0.0, Method: Compositional matrix adjust. Identities = 550/551 (99%), Positives = 551/551 (100%), Gaps = 0/551 (0%) Query 15 VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD 74 +GSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD Sbjct 1 MGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD 60 Query 75 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD 134 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD Sbjct 61 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD 120 Query 135 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA 194 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA Sbjct 121 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA 180 Query 195 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA 254 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA Sbjct 181 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA 240 Query 255 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 314 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL Sbjct 241 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 300 Query 315 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD 374 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD Sbjct 301 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD 360 Query 375 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLP 434 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLP Sbjct 361 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLP 420 Query 435 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRN 494 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRN Sbjct 421 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRN 480 Query 495 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGA 554 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGA Sbjct 481 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGA 540 Query 555 LPPPRKKSRRR 565 LPPPRKKSRRR Sbjct 541 LPPPRKKSRRR 551 >gi|297729975|ref|ZP_06959093.1| putative uroporphyrin-III C-methyltransferase [Mycobacterium tuberculosis KZN R506] gi|308374025|ref|ZP_07434557.2| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis SUMu006] gi|308343308|gb|EFP32159.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis SUMu006] Length=534 Score = 1059 bits (2738), Expect = 0.0, Method: Compositional matrix adjust. Identities = 533/534 (99%), Positives = 534/534 (100%), Gaps = 0/534 (0%) Query 32 VLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAV 91 +LANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAV Sbjct 1 MLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAV 60 Query 92 VSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIE 151 VSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIE Sbjct 61 VSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIE 120 Query 152 IVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESA 211 IVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESA Sbjct 121 IVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESA 180 Query 212 RSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPL 271 RSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPL Sbjct 181 RSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPL 240 Query 272 IVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP 331 IVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP Sbjct 241 IVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP 300 Query 332 PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTA 391 PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTA Sbjct 301 PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTA 360 Query 392 DRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERG 451 DRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERG Sbjct 361 DRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERG 420 Query 452 WEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACI 511 WEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACI Sbjct 421 WEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACI 480 Query 512 GPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR 565 GPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR Sbjct 481 GPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR 534 >gi|340625539|ref|YP_004743991.1| putative uroporphyrin-III C-methyltransferase HEMD [Mycobacterium canettii CIPT 140010059] gi|340003729|emb|CCC42854.1| putative uroporphyrin-III C-methyltransferase HEMD (uroporphyrinogen III methylase) (urogen III methylase) (SUMT) (urogen III methylase) (UROM) [Mycobacterium canettii CIPT 140010059] Length=562 Score = 1047 bits (2707), Expect = 0.0, Method: Compositional matrix adjust. Identities = 557/565 (99%), Positives = 558/565 (99%), Gaps = 3/565 (0%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPV+ALIGTDLPPV Sbjct 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVLALIGTDLPPV 60 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 SGPAPAEPVAGNGDAAGGGSAQE GRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV Sbjct 61 SGPAPAEPVAGNGDAAGGGSAQEQGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR Sbjct 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE Sbjct 181 GD---VDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 237 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTLQGLTDPAVLGA DPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV Sbjct 238 TTLQGLTDPAVLGAADPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 297 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA Sbjct 298 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 357 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP Sbjct 358 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 417 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG Sbjct 418 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 477 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD Sbjct 478 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 537 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSRRR Sbjct 538 ALAEHAARLRAEGALPPPRKKSRRR 562 >gi|289568435|ref|ZP_06448662.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis T17] gi|289542189|gb|EFD45837.1| uroporphyrin-III C-methyltransferase hemD [Mycobacterium tuberculosis T17] Length=565 Score = 1044 bits (2700), Expect = 0.0, Method: Compositional matrix adjust. Identities = 553/565 (98%), Positives = 556/565 (99%), Gaps = 0/565 (0%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV Sbjct 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV Sbjct 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR Sbjct 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE Sbjct 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV Sbjct 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA Sbjct 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGESTADR A+ + +GEQSSLGLLDDFPP Sbjct 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADREAAYYAQRQRPAAGEQSSLGLLDDFPP 420 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG Sbjct 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD Sbjct 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSRRR Sbjct 541 ALAEHAARLRAEGALPPPRKKSRRR 565 >gi|41410102|ref|NP_962938.1| hypothetical protein MAP4004 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41398935|gb|AAS06554.1| CysG [Mycobacterium avium subsp. paratuberculosis K-10] Length=552 Score = 986 bits (2549), Expect = 0.0, Method: Compositional matrix adjust. Identities = 499/564 (89%), Positives = 528/564 (94%), Gaps = 14/564 (2%) Query 2 TRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVS 61 TRGRKP PGRI +VGSGPGDPGLLT RAA VLANAALVFTDPDVPEPV+ALIG DLPPVS Sbjct 3 TRGRKPTPGRITYVGSGPGDPGLLTARAATVLANAALVFTDPDVPEPVLALIGKDLPPVS 62 Query 62 GPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVD 121 GPAPAEP A NG+ GS E G+A AV+SGGPDIRPALGDPA+VAKTLTAEAR+GVD Sbjct 63 GPAPAEP-ASNGE----GSGSEQGQAQPAVISGGPDIRPALGDPAEVAKTLTAEARTGVD 117 Query 122 VVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRI 181 VVRLVAGDPLTVDAVI+EVNA+AR+HLHIEIVPGLA ++AVPTYAGLPLGSSHT+ADVR Sbjct 118 VVRLVAGDPLTVDAVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRG 177 Query 182 DPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVET 241 D DW+ALAAAPGPLILQATASHLA++AR+LI+H+LAE+TPCVVTAHGTTCQQRS+ET Sbjct 178 D---VDWEALAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIET 234 Query 242 TLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVP 301 TLQGLTD AVLG TDPA G PL+VTIGKTV++R KLNWWESRALYGWTVLVP Sbjct 235 TLQGLTDSAVLGGTDPAGPLTG------PLVVTIGKTVSARTKLNWWESRALYGWTVLVP 288 Query 302 RTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAV 361 RTKDQAGEMSERLTSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAV Sbjct 289 RTKDQAGEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAV 348 Query 362 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPY 421 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLDDFPPY Sbjct 349 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPY 408 Query 422 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF 481 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGF Sbjct 409 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGF 468 Query 482 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDA 541 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDA Sbjct 469 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDA 528 Query 542 LAEHAARLRAEGALPPPRKKSRRR 565 LAEHAARLRAEGALPPPRKKSRRR Sbjct 529 LAEHAARLRAEGALPPPRKKSRRR 552 >gi|336460522|gb|EGO39417.1| uroporphyrinogen-III synthase [Mycobacterium avium subsp. paratuberculosis S397] Length=552 Score = 986 bits (2548), Expect = 0.0, Method: Compositional matrix adjust. Identities = 499/564 (89%), Positives = 528/564 (94%), Gaps = 14/564 (2%) Query 2 TRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVS 61 TRGRKP PGRI +VGSGPGDPGLLT RAA VLANAALVFTDPDVPEPV+ALIG DLPPVS Sbjct 3 TRGRKPTPGRITYVGSGPGDPGLLTARAATVLANAALVFTDPDVPEPVLALIGKDLPPVS 62 Query 62 GPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVD 121 GPAPAEP A NG+ GS E G+A AV+SGGPDIRPALGDPA+VAKTLTAEAR+GVD Sbjct 63 GPAPAEP-ASNGE----GSGSEQGQAQLAVISGGPDIRPALGDPAEVAKTLTAEARTGVD 117 Query 122 VVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRI 181 VVRLVAGDPLTVDAVI+EVNA+AR+HLHIEIVPGLA ++AVPTYAGLPLGSSHT+ADVR Sbjct 118 VVRLVAGDPLTVDAVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRG 177 Query 182 DPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVET 241 D DW+ALAAAPGPLILQATASHLA++AR+LI+H+LAE+TPCVVTAHGTTCQQRS+ET Sbjct 178 D---VDWEALAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIET 234 Query 242 TLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVP 301 TLQGLTD AVLG TDPA G PL+VTIGKTV++R KLNWWESRALYGWTVLVP Sbjct 235 TLQGLTDSAVLGGTDPAGPLTG------PLVVTIGKTVSARTKLNWWESRALYGWTVLVP 288 Query 302 RTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAV 361 RTKDQAGEMSERLTSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAV Sbjct 289 RTKDQAGEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAV 348 Query 362 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPY 421 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLDDFPPY Sbjct 349 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPY 408 Query 422 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF 481 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGF Sbjct 409 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGF 468 Query 482 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDA 541 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDA Sbjct 469 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDA 528 Query 542 LAEHAARLRAEGALPPPRKKSRRR 565 LAEHAARLRAEGALPPPRKKSRRR Sbjct 529 LAEHAARLRAEGALPPPRKKSRRR 552 >gi|342858984|ref|ZP_08715638.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium colombiense CECT 3035] gi|342133225|gb|EGT86428.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium colombiense CECT 3035] Length=553 Score = 979 bits (2530), Expect = 0.0, Method: Compositional matrix adjust. Identities = 498/564 (89%), Positives = 525/564 (94%), Gaps = 13/564 (2%) Query 2 TRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVS 61 TRGRKP PGRI +VGSGPGDPGLLTTRAA VLANAALVFTDPDVPEPV+ALIG DLPPVS Sbjct 3 TRGRKPTPGRITYVGSGPGDPGLLTTRAATVLANAALVFTDPDVPEPVLALIGKDLPPVS 62 Query 62 GPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVD 121 GPAPAEP A NGD GG+ Q G+ AV+ GGPDIRPALGDPA+VAKTLTAEAR+GVD Sbjct 63 GPAPAEPAATNGD---GGADQ--GKVQPAVICGGPDIRPALGDPAEVAKTLTAEARTGVD 117 Query 122 VVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRI 181 VVRLV GDPLTVD VI+EVNA+AR+HLHIEIVPGLA S AVPTYAGLPLGSSHTVADVR Sbjct 118 VVRLVPGDPLTVDGVITEVNAIARSHLHIEIVPGLAPSDAVPTYAGLPLGSSHTVADVR- 176 Query 182 DPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVET 241 DP + DW+ALAAAPGPLILQAT+SHLA++AR+LI+H+LAE+TPCVVTA GTTCQQRS+ET Sbjct 177 DP-HVDWEALAAAPGPLILQATSSHLADAARTLIEHELAETTPCVVTAQGTTCQQRSIET 235 Query 242 TLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVP 301 TL GLTD AVLG TDPA G PL+VTIGKTV SRAKLNWWESRALYGWTVLVP Sbjct 236 TLHGLTDSAVLGGTDPAGPLTG------PLVVTIGKTVASRAKLNWWESRALYGWTVLVP 289 Query 302 RTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAV 361 RTKDQAGEMSERLTSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAV Sbjct 290 RTKDQAGEMSERLTSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAV 349 Query 362 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPY 421 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLDDFPPY Sbjct 350 RAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPY 409 Query 422 DSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF 481 DS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGF Sbjct 410 DSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGF 469 Query 482 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDA 541 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDA Sbjct 470 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDA 529 Query 542 LAEHAARLRAEGALPPPRKKSRRR 565 LAEHAARLRAEGALPPPRKKSRRR Sbjct 530 LAEHAARLRAEGALPPPRKKSRRR 553 >gi|183980869|ref|YP_001849160.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium marinum M] gi|183174195|gb|ACC39305.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium marinum M] Length=558 Score = 966 bits (2496), Expect = 0.0, Method: Compositional matrix adjust. Identities = 498/566 (88%), Positives = 530/566 (94%), Gaps = 10/566 (1%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKPRPGRI +VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPE V+ALIG DLPPV Sbjct 2 MTRGRKPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPPV 61 Query 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 SGPAPA VA N DAA GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct 62 SGPAPATAVADNADAATGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 121 Query 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct 122 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 181 Query 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct 182 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 238 Query 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 ETTLQGLTDPA+LG TDPA G PL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct 239 ETTLQGLTDPAILGGTDPAGPLTG------PLVVTIGKTVSNRAKLNWWESRALYGWTVL 292 Query 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct 293 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTN 352 Query 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct 353 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 412 Query 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTG Sbjct 413 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTG 472 Query 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct 473 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 532 Query 540 DALAEHAARLRAEGALPPPRKKSRRR 565 DALAEHAARLRAEGALPPPRKKSRRR Sbjct 533 DALAEHAARLRAEGALPPPRKKSRRR 558 >gi|254777075|ref|ZP_05218591.1| hypothetical protein MaviaA2_20749 [Mycobacterium avium subsp. avium ATCC 25291] Length=537 Score = 963 bits (2489), Expect = 0.0, Method: Compositional matrix adjust. Identities = 488/551 (89%), Positives = 517/551 (94%), Gaps = 14/551 (2%) Query 15 VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD 74 +GSGPGDPGLLT RAA VLANAALVFTDPDVPEPV+ALIG DLPPVSGPAPAEP A NG+ Sbjct 1 MGSGPGDPGLLTARAATVLANAALVFTDPDVPEPVLALIGKDLPPVSGPAPAEP-ASNGE 59 Query 75 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD 134 GS E G+A AV+SGGPDIRPALGDPA+VAKTLTAEAR+G DVVRLVAGDPLTVD Sbjct 60 ----GSGSEQGQAQPAVISGGPDIRPALGDPAEVAKTLTAEARTGADVVRLVAGDPLTVD 115 Query 135 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA 194 AVI+EVNA+AR+HLHIEIVPGLA ++AVPTYAGLPLGSSHT+ADVR D DW+ALAAA Sbjct 116 AVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRGD---VDWEALAAA 172 Query 195 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA 254 PGPLILQATASHLA++AR+LI+H+LAE+TPCVVTAHGTTCQQRS+ETTLQGLTD AVLG Sbjct 173 PGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIETTLQGLTDSAVLGG 232 Query 255 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 314 TDPA G PL+VTIGKTV++RAKLNWWESRALYGWTVLVPRTKDQAGEMSERL Sbjct 233 TDPAGPLTG------PLVVTIGKTVSARAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 286 Query 315 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD 374 TSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAVRAVWEKFGEFGLD Sbjct 287 TSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLD 346 Query 375 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLP 434 ARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLDDFPPYDSVFDPVNRVLLP Sbjct 347 ARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSVFDPVNRVLLP 406 Query 435 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRN 494 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRN Sbjct 407 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRN 466 Query 495 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGA 554 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDALAEHAARLRAEGA Sbjct 467 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEGA 526 Query 555 LPPPRKKSRRR 565 LPPPRKKSRRR Sbjct 527 LPPPRKKSRRR 537 >gi|118619688|ref|YP_908020.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium ulcerans Agy99] gi|118571798|gb|ABL06549.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium ulcerans Agy99] Length=557 Score = 962 bits (2487), Expect = 0.0, Method: Compositional matrix adjust. Identities = 497/566 (88%), Positives = 529/566 (94%), Gaps = 10/566 (1%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKPRPGRI +VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPE V+ALIG DLPPV Sbjct 1 MTRGRKPRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGNDLPPV 60 Query 61 SGPAPAEPVAGNGDAAGGGSAQ-EHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSG 119 SGPAPA VA N DAA GG A+ E +A AVVS GPDIRPALGDP +VAKTLTAEARSG Sbjct 61 SGPAPATAVADNADAATGGPAEGESDQAVPAVVSSGPDIRPALGDPTEVAKTLTAEARSG 120 Query 120 VDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADV 179 DVVRLVAGDP++VDAVI+EVNA+ R+HL IEI+PGLAA+SAVPTYAGLPLGS+HTVADV Sbjct 121 ADVVRLVAGDPMSVDAVIAEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADV 180 Query 180 RIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSV 239 R D DW+ALAAAPGPLILQATASHLA++AR+L++H+LA++TPCVVTAHGTTCQQRSV Sbjct 181 RGD---VDWEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQRSV 237 Query 240 ETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVL 299 ETTLQGLTDPA+LG TDPA G PL+VTIGKTV++RAKLNWWESRALYGWTVL Sbjct 238 ETTLQGLTDPAILGGTDPAGPLTG------PLVVTIGKTVSNRAKLNWWESRALYGWTVL 291 Query 300 VPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTN 359 VPRTKDQAGEMSERLTSYGALPVEVPTIAV PPRSPAQMERAVKGLVDGRFQW+VFTSTN Sbjct 292 VPRTKDQAGEMSERLTSYGALPVEVPTIAVAPPRSPAQMERAVKGLVDGRFQWVVFTSTN 351 Query 360 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFP 419 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLD+FP Sbjct 352 AVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFP 411 Query 420 PYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTG 479 PYDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTG Sbjct 412 PYDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTG 471 Query 480 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLV 539 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLV Sbjct 472 GFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLV 531 Query 540 DALAEHAARLRAEGALPPPRKKSRRR 565 DALAEHAARLRAEGALPPPRKKSRRR Sbjct 532 DALAEHAARLRAEGALPPPRKKSRRR 557 >gi|254821057|ref|ZP_05226058.1| hypothetical protein MintA_14067 [Mycobacterium intracellulare ATCC 13950] Length=536 Score = 955 bits (2469), Expect = 0.0, Method: Compositional matrix adjust. Identities = 483/551 (88%), Positives = 513/551 (94%), Gaps = 15/551 (2%) Query 15 VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD 74 +GSGPGDPGLLTTRAA VL NAALVFTDPDVPEPV+ALIG DLPPVSGPAPA+P A +GD Sbjct 1 MGSGPGDPGLLTTRAATVLTNAALVFTDPDVPEPVLALIGKDLPPVSGPAPADPAASSGD 60 Query 75 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD 134 A + G+ AV+SGGPDIRPALGDPA+VAKTLT EAR+GVDVVRLVAGDPLTVD Sbjct 61 GA------DQGQTQPAVISGGPDIRPALGDPAEVAKTLTHEARTGVDVVRLVAGDPLTVD 114 Query 135 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA 194 AVI+EVNA+AR+HLHIEIVPGLA ++AVPTYAGLPLGSSHTVADVR D DW+ALAAA Sbjct 115 AVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTVADVRGD---VDWEALAAA 171 Query 195 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA 254 PGPLILQAT+SHLA++AR+LI+H+LAE+TPCVVTA GTTCQQRS+ETTL GLTD AVLG Sbjct 172 PGPLILQATSSHLADAARTLIEHELAENTPCVVTAQGTTCQQRSIETTLHGLTDSAVLGG 231 Query 255 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 314 TDPA G PL+VTIGKTV+SRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL Sbjct 232 TDPAGPLTG------PLVVTIGKTVSSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 285 Query 315 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD 374 TSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAVRAVWEKFGEFGLD Sbjct 286 TSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLD 345 Query 375 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLP 434 ARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLDDFPPYDSVFDPVNRVLLP Sbjct 346 ARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSVFDPVNRVLLP 405 Query 435 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRN 494 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRN Sbjct 406 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRN 465 Query 495 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGA 554 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDALAEHAARLRAEGA Sbjct 466 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEGA 525 Query 555 LPPPRKKSRRR 565 LPPPRKKSRRR Sbjct 526 LPPPRKKSRRR 536 >gi|240171919|ref|ZP_04750578.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium kansasii ATCC 12478] Length=557 Score = 952 bits (2461), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/565 (89%), Positives = 529/565 (94%), Gaps = 9/565 (1%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTRGRKP PGRI FVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPV+ALIG DLPPV Sbjct 2 MTRGRKPTPGRITFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVLALIGKDLPPV 61 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 SGPAPA AG G +A E +A AVVS GPDIRPALG+PADVAKTLTAEARSG Sbjct 62 SGPAPAAAHAGENV---GVAAGESAPSAPAVVSSGPDIRPALGEPADVAKTLTAEARSGA 118 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPL+VDAVI+EVNAVARTHLH E+VPGLAA+SAVPTYAGLPLGSSHTVADVR Sbjct 119 DVVRLVAGDPLSVDAVITEVNAVARTHLHFEVVPGLAATSAVPTYAGLPLGSSHTVADVR 178 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + ++TDWDALAAAPGPLILQATASHLA++AR+L+DH+LA++TPCVVTAHGTTCQQRSVE Sbjct 179 GELDDTDWDALAAAPGPLILQATASHLADAARTLLDHELADTTPCVVTAHGTTCQQRSVE 238 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTLQGLTDPA+LG DPA AGPL+VTIGKTV++R KLNWWESRALYGWTVLV Sbjct 239 TTLQGLTDPAILGGADPA------GPFAGPLVVTIGKTVSNRGKLNWWESRALYGWTVLV 292 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNA Sbjct 293 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 352 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSS+GLLD+FPP Sbjct 353 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSMGLLDEFPP 412 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YDS+FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGG Sbjct 413 YDSIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGG 472 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVD Sbjct 473 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVD 532 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSRRR Sbjct 533 ALAEHAARLRAEGALPPPRKKSRRR 557 >gi|118465929|ref|YP_883767.1| uroporphyrinogen-III synthase [Mycobacterium avium 104] gi|118167216|gb|ABK68113.1| uroporphyrinogen-III synthase [Mycobacterium avium 104] Length=537 Score = 936 bits (2419), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/551 (89%), Positives = 518/551 (95%), Gaps = 14/551 (2%) Query 15 VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD 74 +GSGPGDPGLLT RAAAVLANAALVFTDPDVPEPV+ALIG DLPPVSGPAPAEP A NG+ Sbjct 1 MGSGPGDPGLLTARAAAVLANAALVFTDPDVPEPVLALIGKDLPPVSGPAPAEP-APNGE 59 Query 75 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD 134 AG E G+A AV+SGGPDIRPALGDPA+VAKTLTAEAR+GVDVVRLVAGDPLTVD Sbjct 60 GAG----SEQGQAQPAVISGGPDIRPALGDPAEVAKTLTAEARTGVDVVRLVAGDPLTVD 115 Query 135 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA 194 AVI+EVNA+AR+HLHIEIVPGLA ++AVPTYAGLPLGSSHT+ADVR D DW+ALAAA Sbjct 116 AVITEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRGD---VDWEALAAA 172 Query 195 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA 254 PGPLILQATASHLA++AR+LI+H+LAE+TPCVVTAHGTTCQQRS+ETTLQGLTD AVLG Sbjct 173 PGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQRSIETTLQGLTDSAVLGG 232 Query 255 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 314 TDPA G PL+VTIGKTV++RAKLNWWESRALYGWTVLVPRTKDQAGEMSERL Sbjct 233 TDPAGPLTG------PLVVTIGKTVSARAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 286 Query 315 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD 374 TSYGALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAVRAVWEKFGEFGLD Sbjct 287 TSYGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLD 346 Query 375 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLP 434 ARAFSGVKIACVGESTADRVRAFGISPELVP+GEQSSLGLLDDFP YDSVFDPVNRVLLP Sbjct 347 ARAFSGVKIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPLYDSVFDPVNRVLLP 406 Query 435 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRN 494 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRN Sbjct 407 RADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRN 466 Query 495 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGA 554 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDALAEHAARLRAEGA Sbjct 467 LVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEGA 526 Query 555 LPPPRKKSRRR 565 LPPPRKKSRRR Sbjct 527 LPPPRKKSRRR 537 >gi|15828302|ref|NP_302565.1| uroporphyrin-III C-methyltransferase [Mycobacterium leprae TN] gi|221230779|ref|YP_002504195.1| putative uroporphyrin-III C-methyltransferase [Mycobacterium leprae Br4923] gi|13093995|emb|CAC31936.1| possible uroporphyrin-III C-methyltransferase [Mycobacterium leprae] gi|219933886|emb|CAR72518.1| possible uroporphyrin-III C-methyltransferase [Mycobacterium leprae Br4923] Length=563 Score = 915 bits (2366), Expect = 0.0, Method: Compositional matrix adjust. Identities = 484/565 (86%), Positives = 509/565 (91%), Gaps = 10/565 (1%) Query 2 TRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVS 61 TRGRK RPGRI FVG+GPG PGLLT +A AVLANAALVF DPDVPEPV+ALIG DLPPVS Sbjct 8 TRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPPVS 67 Query 62 GPAPAEPVAGN-GDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 GPAPA P A G AA G +H +AA V+SGG DIRPALGDP +VAKTLTAEARSGV Sbjct 68 GPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMSGGADIRPALGDPTEVAKTLTAEARSGV 127 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPLTVDAVI+EVNAVART+L IEIVPGL SS VPTYAGLPLGSSHTVADVR Sbjct 128 DVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVR 187 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW+ALAAAPGPLILQATASHLA++A LIDH L ++TPCVVTA GTTCQQRSVE Sbjct 188 GD---VDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVE 244 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTL+GL D AVL TD A G PL+VTIGKTVTSRA+LNWWESRALYGWTVLV Sbjct 245 TTLEGLADSAVLVGTDTAGPLTG------PLVVTIGKTVTSRARLNWWESRALYGWTVLV 298 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNA Sbjct 299 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 358 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGE+TADRVRAFGISPELVP+GEQSSLGLLD+FPP Sbjct 359 VRAVWEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPP 418 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YDSVFDPVNRVLLPRADIATETLAEGLR GWEIEDVTAYRTVRAAPPPA TREMIKTGG Sbjct 419 YDSVFDPVNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGG 478 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART+IACIGPKTAETA+EFGLRVDVQP+TAA+GPLVD Sbjct 479 FDAVCFTSSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPETAAVGPLVD 538 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEH ARLRAEGALPPPRKKSRRR Sbjct 539 ALAEHVARLRAEGALPPPRKKSRRR 563 >gi|296168170|ref|ZP_06850191.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295896848|gb|EFG76477.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=522 Score = 908 bits (2347), Expect = 0.0, Method: Compositional matrix adjust. Identities = 468/541 (87%), Positives = 495/541 (92%), Gaps = 19/541 (3%) Query 25 LTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEH 84 +TTRAA VLANAALVFTDPDVPEPV+ALIG DLPPVSGPA GG A Sbjct 1 MTTRAATVLANAALVFTDPDVPEPVLALIGKDLPPVSGPA-----------PAGGDAATG 49 Query 85 GRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVA 144 G AV+S GPD+RPALG+PA+VAKTLTAEAR+G DVVRLVAGDPLTVDAVI+EVNAVA Sbjct 50 GAEQPAVISAGPDVRPALGEPAEVAKTLTAEARTGADVVRLVAGDPLTVDAVITEVNAVA 109 Query 145 RTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATA 204 ++HLH+EIVPGLA + AVPTYAGLPLGSSHTVADVR DP+ DWDALAAAPGPLILQAT Sbjct 110 KSHLHLEIVPGLAPAGAVPTYAGLPLGSSHTVADVR-DPQ-VDWDALAAAPGPLILQATT 167 Query 205 SHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGR 264 SHLA++AR+LI+H+LAE+TPCVVTAHGTTCQQRS+ETTL GLTD AVLG TDPA G Sbjct 168 SHLADAARTLIEHELAETTPCVVTAHGTTCQQRSIETTLGGLTDSAVLGGTDPAGPLTG- 226 Query 265 DSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEV 324 PL+VTIGKTV SRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALP+EV Sbjct 227 -----PLVVTIGKTVASRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPIEV 281 Query 325 PTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIA 384 PTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAVRAVWEKFGEFGLDARAFSGVKIA Sbjct 282 PTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGVKIA 341 Query 385 CVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLA 444 CVGESTADRVRAFGISPELVP+GEQSSLGLLDDFPPYDS+FDPVNRVLLPRADIATETLA Sbjct 342 CVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPPYDSIFDPVNRVLLPRADIATETLA 401 Query 445 EGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHA 504 EGLRERGWEIEDVTAYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHA Sbjct 402 EGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHA 461 Query 505 RTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRR 564 RTIIACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDALAEHAARLRAEGALPPPRKKSRR Sbjct 462 RTIIACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAEGALPPPRKKSRR 521 Query 565 R 565 R Sbjct 522 R 522 >gi|333989146|ref|YP_004521760.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium sp. JDM601] gi|333485114|gb|AEF34506.1| uroporphyrin-III C-methyltransferase HemD [Mycobacterium sp. JDM601] Length=549 Score = 886 bits (2290), Expect = 0.0, Method: Compositional matrix adjust. Identities = 455/553 (83%), Positives = 495/553 (90%), Gaps = 4/553 (0%) Query 13 VFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGN 72 +FVGSGPGDPGLLT RA L NAALVF DPDVPE V+ L+GTDLPP++GP P +P A Sbjct 1 MFVGSGPGDPGLLTARARTALTNAALVFVDPDVPEAVLGLVGTDLPPIAGPVPPDPKADK 60 Query 73 GDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLT 132 D A G+A AA+ V GGPDIRPALG+PA+VAK LTAEARSG DVVRLVAGDPL+ Sbjct 61 TDTAQEGAADAEDAAAT--VPGGPDIRPALGEPAEVAKILTAEARSGADVVRLVAGDPLS 118 Query 133 VDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALA 192 VD+VI+EVNAVART + EIVPGL A+SAVPTYAGLPLGSSHTVADVR DP + DW ALA Sbjct 119 VDSVITEVNAVARTTVQFEIVPGLPATSAVPTYAGLPLGSSHTVADVR-DP-HVDWAALA 176 Query 193 AAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVL 252 AAPGPLILQAT SHL E+AR+LI++ LA++TPCVVT GTTC QRSVE +L LTDPA L Sbjct 177 AAPGPLILQATTSHLPEAARTLIEYGLADATPCVVTTSGTTCAQRSVEASLSALTDPASL 236 Query 253 GATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSE 312 + DP NG+++ AGPL+VTIGKTV +RAKLNWWESRALYGWTVLVPRTKDQAGEMSE Sbjct 237 ASIDPVILPNGQETAAGPLVVTIGKTVNNRAKLNWWESRALYGWTVLVPRTKDQAGEMSE 296 Query 313 RLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFG 372 +L +GA PVEVPTIAVEPPRSPAQMERAVKGLVDGR+QW+VFTSTNAVRAVWEKFGEFG Sbjct 297 KLVGHGASPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFGEFG 356 Query 373 LDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVL 432 LDARAFSGVKIACVGE+TA+RVRAFGISPELVP+GEQSSLGLLD+FPPYD VFDPVNRVL Sbjct 357 LDARAFSGVKIACVGEATAERVRAFGISPELVPAGEQSSLGLLDEFPPYDDVFDPVNRVL 416 Query 433 LPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTV 492 LPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAT REMIKTGGFDAVCFTSSSTV Sbjct 417 LPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATIREMIKTGGFDAVCFTSSSTV 476 Query 493 RNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAE 552 RNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQP+TAA+GPLVDALAEHAARLRAE Sbjct 477 RNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPETAAVGPLVDALAEHAARLRAE 536 Query 553 GALPPPRKKSRRR 565 GALPPPRKKSRRR Sbjct 537 GALPPPRKKSRRR 549 >gi|167967418|ref|ZP_02549695.1| uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Mycobacterium tuberculosis H37Ra] Length=437 Score = 879 bits (2272), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/437 (100%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 129 DPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDW 188 DPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDW Sbjct 1 DPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDW 60 Query 189 DALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTD 248 DALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTD Sbjct 61 DALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTD 120 Query 249 PAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAG 308 PAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAG Sbjct 121 PAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAG 180 Query 309 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKF 368 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKF Sbjct 181 EMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKF 240 Query 369 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPV 428 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPV Sbjct 241 GEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPV 300 Query 429 NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTS 488 NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTS Sbjct 301 NRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTS 360 Query 489 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAAR 548 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAAR Sbjct 361 SSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAAR 420 Query 549 LRAEGALPPPRKKSRRR 565 LRAEGALPPPRKKSRRR Sbjct 421 LRAEGALPPPRKKSRRR 437 >gi|108797658|ref|YP_637855.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. MCS] gi|119866745|ref|YP_936697.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. KMS] gi|108768077|gb|ABG06799.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. MCS] gi|119692834|gb|ABL89907.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. KMS] Length=554 Score = 875 bits (2260), Expect = 0.0, Method: Compositional matrix adjust. Identities = 446/563 (80%), Positives = 496/563 (89%), Gaps = 16/563 (2%) Query 3 RGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSG 62 RGRK +PGRI FVGSGPGDPGLLT RA +VL NAALVFTDPDVPE V++L+G LPP SG Sbjct 8 RGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSG 67 Query 63 PAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDV 122 P PAEP + AG + + GGPDIRPALGDPA+VAK L EA+ GVDV Sbjct 68 PEPAEPADAADEQAG------------STIPGGPDIRPALGDPAEVAKVLAGEAKHGVDV 115 Query 123 VRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRID 182 VRLVAGDPL+VDAVI+EVNA+A++H + EIVPGL ++AVPTYAGLPLGS+HTVADVR D Sbjct 116 VRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVR-D 174 Query 183 PENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETT 242 P N DW ALAAAPGPLIL ATASHL ++AR+LI++ LAE+TP VVTA+GTTCQQRSVE+T Sbjct 175 P-NVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVEST 233 Query 243 LQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPR 302 L GL D A L T P + AGPL+VT+G+TVT+RA+LNWWESRALYGWTVLVPR Sbjct 234 LSGLLDKAAL--TAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPR 291 Query 303 TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVR 362 TKDQAGEMS++L +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAVR Sbjct 292 TKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 351 Query 363 AVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYD 422 AVWEKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP+GEQSSLGLLD+FPPYD Sbjct 352 AVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYD 411 Query 423 SVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFD 482 +FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA+TREMIKTGGFD Sbjct 412 DIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFD 471 Query 483 AVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDAL 542 AVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQP+ AA+GPLV+AL Sbjct 472 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEAL 531 Query 543 AEHAARLRAEGALPPPRKKSRRR 565 AEHAARLRAEGALPPPRKKSRRR Sbjct 532 AEHAARLRAEGALPPPRKKSRRR 554 >gi|126433282|ref|YP_001068973.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. JLS] gi|126233082|gb|ABN96482.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. JLS] Length=554 Score = 874 bits (2257), Expect = 0.0, Method: Compositional matrix adjust. Identities = 446/563 (80%), Positives = 496/563 (89%), Gaps = 16/563 (2%) Query 3 RGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSG 62 RGRK +PGRI FVGSGPGDPGLLT RA +VL NAALVFTDPDVPE V++L+G LPP SG Sbjct 8 RGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSG 67 Query 63 PAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDV 122 P PAEP + AG + + GGPDIRPALGDPA+VAK L EA+ GVDV Sbjct 68 PEPAEPADAADEQAG------------STIPGGPDIRPALGDPAEVAKVLAGEAKHGVDV 115 Query 123 VRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRID 182 VRLVAGDPL+VDAVI+EVNA+A++H + EIVPGL ++AVPTYAGLPLGS+HTVADVR D Sbjct 116 VRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVR-D 174 Query 183 PENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETT 242 P N DW ALAAAPGPLIL ATASHL ++AR+LI++ LAE+TP VVTA+GTTCQQRSVE+T Sbjct 175 P-NVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVEST 233 Query 243 LQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPR 302 L GL D A L T P + AGPL+VT+G+TVT+RA+LNWWESRALYGWTVLVPR Sbjct 234 LFGLLDKAAL--TAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPR 291 Query 303 TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVR 362 TKDQAGEMS++L +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNAVR Sbjct 292 TKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVR 351 Query 363 AVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYD 422 AVWEKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP+GEQSSLGLLD+FPPYD Sbjct 352 AVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYD 411 Query 423 SVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFD 482 +FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA+TREMIKTGGFD Sbjct 412 DIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFD 471 Query 483 AVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDAL 542 AVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQP+ AA+GPLV+AL Sbjct 472 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEAL 531 Query 543 AEHAARLRAEGALPPPRKKSRRR 565 AEHAARLRAEGALPPPRKKSRRR Sbjct 532 AEHAARLRAEGALPPPRKKSRRR 554 >gi|120401861|ref|YP_951690.1| uroporphyrinogen III synthase HEM4 [Mycobacterium vanbaalenii PYR-1] gi|119954679|gb|ABM11684.1| uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase [Mycobacterium vanbaalenii PYR-1] Length=571 Score = 863 bits (2230), Expect = 0.0, Method: Compositional matrix adjust. Identities = 449/573 (79%), Positives = 496/573 (87%), Gaps = 15/573 (2%) Query 3 RGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV-- 60 RGRK +PGRI FVGSGPGDPGLLTTRA AVLA+AALVFTDPDVPE V+ L+G++LPP Sbjct 4 RGRKGKPGRITFVGSGPGDPGLLTTRARAVLAHAALVFTDPDVPEAVLELVGSELPPPSG 63 Query 61 --------SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTL 112 + P PA+ V A A+ A AV+ GGPD+RPALGDP +VAKTL Sbjct 64 PLPPVAAGAAPKPADAVVKQDADAAEKPAEGSKAAEDAVIPGGPDVRPALGDPVEVAKTL 123 Query 113 TAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGS 172 EAR+GVDVVRLVAGDPL++D+VI+E+NA+A+T L+ EIVPGL +SAVPTYAGLPLGS Sbjct 124 ATEARTGVDVVRLVAGDPLSIDSVITEINALAKTQLNFEIVPGLPGTSAVPTYAGLPLGS 183 Query 173 SHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGT 232 SHTVADVR DP N DW ALAAAPGPLIL ATASHL E+AR+LI++ LA+STP VVTA+GT Sbjct 184 SHTVADVR-DP-NVDWAALAAAPGPLILHATASHLPEAARTLIEYGLADSTPAVVTANGT 241 Query 233 TCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRA 292 TCQQRS+ETTL GL D AVL D A G L+VT+G+TV RAKLNWWESRA Sbjct 242 TCQQRSIETTLGGLLDKAVL---DKPAVAEPAGPLTGTLVVTLGRTVAHRAKLNWWESRA 298 Query 293 LYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW 352 LYGWTVLVPRTKDQAGEMS+RL +GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW Sbjct 299 LYGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQW 358 Query 353 IVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSL 412 +VFTSTNAVRAVWEKF EFGLDARAFSGVKIACVG++TA+RVRAFGI+PELVP+GEQSSL Sbjct 359 VVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSL 418 Query 413 GLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATT 472 GLLD+FPPYD +FDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA T Sbjct 419 GLLDEFPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQT 478 Query 473 REMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDT 532 REMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDVQP+ Sbjct 479 REMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEV 538 Query 533 AAIGPLVDALAEHAARLRAEGALPPPRKKSRRR 565 AA+GPLV+ALAEHAARLRAEGALPPPRKKSRRR Sbjct 539 AAVGPLVEALAEHAARLRAEGALPPPRKKSRRR 571 >gi|118473053|ref|YP_885357.1| uroporphyrinogen-III synthase [Mycobacterium smegmatis str. MC2 155] gi|118174340|gb|ABK75236.1| uroporphyrinogen-III synthase [Mycobacterium smegmatis str. MC2 155] Length=610 Score = 851 bits (2199), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/571 (79%), Positives = 496/571 (87%), Gaps = 21/571 (3%) Query 6 KPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAP 65 K +PGRI FVGSGPGDPGLLTTRA AVLA+A LVFTDPDVPE V+AL+GTDLPP +GPAP Sbjct 50 KVKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLPPAAGPAP 109 Query 66 AEPVAGNGDAAGGGSAQEHGRAAS-----------AVVSGGPDIRPALGDPADVAKTLTA 114 A+ D A + + + AV+ GGP++RPALGDPA+VAKTL + Sbjct 110 AK----KNDKADKATDKSDKSDKADKADDAKSDDPAVIPGGPEVRPALGDPAEVAKTLAS 165 Query 115 EARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSH 174 EAR G +VVRL+AGDPL+VDAVI+E+NA+A+THL EIVPGL ++AVPTYAGLPLGSSH Sbjct 166 EARHGYNVVRLIAGDPLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSH 225 Query 175 TVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTC 234 TVADVR D DW ALAAAPGPLIL ATASHL ++AR+LI+H L E+TP VVTA+GTTC Sbjct 226 TVADVRGD---VDWAALAAAPGPLILHATASHLPDAARTLIEHGLVENTPAVVTANGTTC 282 Query 235 QQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALY 294 QQRSVETTL GLTD V+ PA S GPL+VTIGKTV +RAKLNWWESRALY Sbjct 283 QQRSVETTLVGLTDKTVV--EKPAGS-ELLGPLTGPLVVTIGKTVANRAKLNWWESRALY 339 Query 295 GWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIV 354 GWTVLVPRTKDQAGEMSERL ++GALP+EVPTIAVEPPRSPAQMERAVKGLVDGRFQW+V Sbjct 340 GWTVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVV 399 Query 355 FTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGL 414 FTSTNAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVPSGEQSSLGL Sbjct 400 FTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGL 459 Query 415 LDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTRE 474 LD+FPPYD VFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPA TRE Sbjct 460 LDEFPPYDEVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTRE 519 Query 475 MIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAA 534 MIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA Sbjct 520 MIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAA 579 Query 535 IGPLVDALAEHAARLRAEGALPPPRKKSRRR 565 +GPLV+ALAEHAARLRAEGALPPPRKKSRRR Sbjct 580 VGPLVEALAEHAARLRAEGALPPPRKKSRRR 610 >gi|145220671|ref|YP_001131349.1| uroporphyrinogen III synthase HEM4 [Mycobacterium gilvum PYR-GCK] gi|315442378|ref|YP_004075257.1| uroporphyrinogen-III C-methyltransferase ;uroporphyrinogen-III synthase [Mycobacterium sp. Spyr1] gi|145213157|gb|ABP42561.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase [Mycobacterium gilvum PYR-GCK] gi|315260681|gb|ADT97422.1| uroporphyrinogen-III C-methyltransferase ;uroporphyrinogen-III synthase [Mycobacterium sp. Spyr1] Length=569 Score = 842 bits (2175), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/577 (79%), Positives = 496/577 (86%), Gaps = 25/577 (4%) Query 3 RGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSG 62 RGRK +PGRI FVGSGPGDPGLLT+RA AVLANAALVFTDPDVPE V AL+G++LPP SG Sbjct 4 RGRKNKPGRITFVGSGPGDPGLLTSRARAVLANAALVFTDPDVPEAVRALVGSELPPPSG 63 Query 63 PAPA--------------EPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADV 108 P P +P + + A +A+ A AV+ GGPD+RPALGDPA+V Sbjct 64 PLPPVADAAPKTAAAGADQPASQDAAPAD--AAKTAKAAEDAVIPGGPDVRPALGDPAEV 121 Query 109 AKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGL 168 AKTL EAR+GVDVVRLVAGDPL+ D+VI+EVNA+A+T L EIVPGL +SAVPTYAGL Sbjct 122 AKTLAHEARTGVDVVRLVAGDPLSNDSVITEVNALAKTQLSFEIVPGLPGTSAVPTYAGL 181 Query 169 PLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVT 228 PLGSSHTVADVR D DW ALAAAPGPLIL AT SHL E+AR+LI++ LAESTP VVT Sbjct 182 PLGSSHTVADVRGD---VDWAALAAAPGPLILHATPSHLPEAARTLIEYGLAESTPAVVT 238 Query 229 AHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWW 288 A+GTTCQQRSVETTL GL D A L T+PA G L+VTIG+TV +RAKLNWW Sbjct 239 ANGTTCQQRSVETTLAGLLDKAALAGTEPAGPLTGT------LVVTIGRTVANRAKLNWW 292 Query 289 ESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDG 348 ESRALYGWTVLVPRTKDQAGEMS+RL +GALP+EVPTIAVEPPRSPAQMERAVKGLVDG Sbjct 293 ESRALYGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDG 352 Query 349 RFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGE 408 RFQW+VFTSTNAVRAVWEKF EFGLDARAFSGVKIACVG++TA++VRAFGI+PELVP+GE Sbjct 353 RFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAEKVRAFGINPELVPTGE 412 Query 409 QSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPP 468 QSSLGLLD+FPPYD +FDPVNRVLLPRADIATETLAEGLRE GWEIEDVTAYRTVRAAPP Sbjct 413 QSSLGLLDEFPPYDDIFDPVNRVLLPRADIATETLAEGLRELGWEIEDVTAYRTVRAAPP 472 Query 469 PATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDV 528 PA TREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETAAEFGLRVDV Sbjct 473 PAHTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDV 532 Query 529 QPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR 565 QP+ AA+GPLV+ALAEHAARLRAEGALPPPRKKSRRR Sbjct 533 QPEVAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR 569 >gi|169631070|ref|YP_001704719.1| uroporphyrin-III C-methyltransferase [Mycobacterium abscessus ATCC 19977] gi|169243037|emb|CAM64065.1| Possible Uroporphyrin-III C-methyltransferase [Mycobacterium abscessus] Length=549 Score = 810 bits (2091), Expect = 0.0, Method: Compositional matrix adjust. Identities = 426/567 (76%), Positives = 477/567 (85%), Gaps = 20/567 (3%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGT--DLP 58 MTRGRK +PGRI+FVGSGPGDPGLLT RA AVL A + FTDPDVP+ V+ L+G+ +LP Sbjct 1 MTRGRK-KPGRILFVGSGPGDPGLLTVRARAVLTGATVAFTDPDVPQAVLDLVGSAVELP 59 Query 59 PVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARS 118 PAPA+P G GD A + E + DIRPALGDPADVAKTL AEARS Sbjct 60 E---PAPAKPATG-GDEAPAAADNEAAAEPPLTI----DIRPALGDPADVAKTLVAEARS 111 Query 119 GVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVAD 178 GVDVVRLVAGDPL++D+V++EV+AV RT + EI+PGLA+S+AVP YAGLP GS+HTVAD Sbjct 112 GVDVVRLVAGDPLSIDSVLAEVHAVTRTQVAFEILPGLASSTAVPAYAGLPPGSAHTVAD 171 Query 179 VRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 VR D DW ALAAAPGPLIL AT +H+ ++A++LI+H LA+ T VTA GTTC QR+ Sbjct 172 VRGD---VDWAALAAAPGPLILHATPTHVPDAAKALIEHGLADQTLVAVTAQGTTCAQRT 228 Query 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 VETTL L D + A DP G L++TIG+ V R+KLNWWESRALYGWTV Sbjct 229 VETTLASLIDGVPVDANDP------HGPMTGALVLTIGRVVAGRSKLNWWESRALYGWTV 282 Query 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 LVPRTKDQAGEMS++L YGALPVEVPTIAVEPPRSPAQMERAVKGLVDGR+QW+VFTST Sbjct 283 LVPRTKDQAGEMSDKLVGYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTST 342 Query 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 NAVRAVWEKF EFGLDARAFSGVKIACVG++TAD+VRAFGI+PELVP+GEQSSLGLLD+F Sbjct 343 NAVRAVWEKFAEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPAGEQSSLGLLDEF 402 Query 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 PPYD VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPP A TREMIKT Sbjct 403 PPYDDVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAQTREMIKT 462 Query 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 GGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TAA+GPL Sbjct 463 GGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPETAAVGPL 522 Query 539 VDALAEHAARLRAEGALPPPRKKSRRR 565 V+ALAEHAARLR EGALPPPRKKSRRR Sbjct 523 VEALAEHAARLRTEGALPPPRKKSRRR 549 >gi|262201011|ref|YP_003272219.1| uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Gordonia bronchialis DSM 43247] gi|262084358|gb|ACY20326.1| Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Gordonia bronchialis DSM 43247] Length=577 Score = 766 bits (1979), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/586 (69%), Positives = 463/586 (80%), Gaps = 43/586 (7%) Query 5 RKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIG---------- 54 +K PGRI+FVGSGPGDP LLT RA V+A+A + DPDVP V++LIG Sbjct 6 KKSNPGRILFVGSGPGDPDLLTVRARTVIAHATTAYIDPDVPAAVISLIGSAYRAEPTPD 65 Query 55 ----TDLPPVSGPAPAEPVAGNG---DAAGGGSAQEHGRAASAVVSGGPD---------I 98 T P + APA+ VA +G D A A + A + GP+ + Sbjct 66 NRRSTKKPAGADDAPADGVAKDGVAKDGAAKDGAAKDDAANKDAAANGPEATADEPDSPV 125 Query 99 RPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAA 158 PALGDPA+VAKTL A A++G DVVR+V+GDPLT D+V+ EVNAVART + E++PGL A Sbjct 126 HPALGDPAEVAKTLVAAAKAGDDVVRVVSGDPLTTDSVLGEVNAVARTSVAFEVLPGLPA 185 Query 159 SSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQ 218 +S VP+YAG+PLGS+HT ADVR + DW ALAAAPGPL+L AT+ HLAE+A +L +H Sbjct 186 ASVVPSYAGMPLGSTHTEADVRGE---VDWAALAAAPGPLVLHATSGHLAETASALTEHG 242 Query 219 LAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKT 278 +A TP +T +GTTCQQR++E TL L + ++ GPLI+TIG Sbjct 243 MAAQTPVAITVNGTTCQQRTIEATLASLNEQG--------------NALTGPLILTIGNV 288 Query 279 VTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQM 338 V++R KL+WWESRALYGWTVLVPRTKDQA +MSERL S+GA+P EVPTIAVEPPRSPAQM Sbjct 289 VSARGKLSWWESRALYGWTVLVPRTKDQAADMSERLVSHGAVPKEVPTIAVEPPRSPAQM 348 Query 339 ERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFG 398 ERAVKGLVDGR+QW+VFTSTNAVRAVWEKF EFGLDARAFSGVKIACVGE+TA+RVR+FG Sbjct 349 ERAVKGLVDGRYQWVVFTSTNAVRAVWEKFAEFGLDARAFSGVKIACVGEATAERVRSFG 408 Query 399 ISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVT 458 I+PEL+PSGEQSSLGLLD+FPPYD VFDPVNR+LLPRADIATETL+EGLRERGWEI+DVT Sbjct 409 INPELIPSGEQSSLGLLDEFPPYDDVFDPVNRILLPRADIATETLSEGLRERGWEIDDVT 468 Query 459 AYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAET 518 AYRTVRAAPPPA TREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAET Sbjct 469 AYRTVRAAPPPAATREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAET 528 Query 519 AAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRR 564 A EFGLRVDVQP+TA+I LVDALAEHAARLRAEGALPPPRKKSRR Sbjct 529 ATEFGLRVDVQPETASIPDLVDALAEHAARLRAEGALPPPRKKSRR 574 >gi|312141092|ref|YP_004008428.1| uroporphyrinogen-iii synthase hemd [Rhodococcus equi 103S] gi|325674098|ref|ZP_08153788.1| multifunctional enzyme siroheme synthase CysG [Rhodococcus equi ATCC 33707] gi|311890431|emb|CBH49749.1| secreted uroporphyrinogen-III synthase HemD [Rhodococcus equi 103S] gi|325555363|gb|EGD25035.1| multifunctional enzyme siroheme synthase CysG [Rhodococcus equi ATCC 33707] Length=521 Score = 761 bits (1965), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/565 (71%), Positives = 453/565 (81%), Gaps = 45/565 (7%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R RK PGRI+FVGSGPGDP LLT RA VLA+AAL FTDPDV + V AL+GT L Sbjct 1 MSRVRKNSPGRILFVGSGPGDPALLTVRAHDVLASAALAFTDPDVDKGVTALVGTALG-- 58 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 P P+A ++RPALG+PA+VAKTL AEA++G Sbjct 59 RDPETDLPIA--------------------------EVRPALGEPAEVAKTLVAEAKNGH 92 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLV+GDPLT D+VI+EV+AVART + E++PGL + SAVP+YAG+ LGS HT ADVR Sbjct 93 DVVRLVSGDPLTTDSVIAEVSAVARTQVVFEVLPGLPSGSAVPSYAGMALGSGHTEADVR 152 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + DW ALAAAPGPL+L AT++HLAE+A +L++H LA TP +T GTT QQR+VE Sbjct 153 GE---VDWAALAAAPGPLVLHATSAHLAETASALVEHGLAPQTPAAITVRGTTRQQRTVE 209 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L D GPLIVT+GK V+ R K++WWESRALYGWTVLV Sbjct 210 ATLATLNDAG--------------SELVGPLIVTVGKVVSQRNKMSWWESRALYGWTVLV 255 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK+QA +MS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QW+VFTSTNA Sbjct 256 PRTKEQAADMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNA 315 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF FGLDARAFSGVKIACVGE+TA++VR+FGI+PELVPSGEQSS GLL DFPP Sbjct 316 VRAVWEKFEAFGLDARAFSGVKIACVGEATAEKVRSFGITPELVPSGEQSSEGLLADFPP 375 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 376 YDEVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGG 435 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+TA +GPLV+ Sbjct 436 FDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAQMGPLVE 495 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSR R Sbjct 496 ALAEHAARLRAEGALPPPRKKSRAR 520 >gi|54027142|ref|YP_121384.1| putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Nocardia farcinica IFM 10152] gi|54018650|dbj|BAD60020.1| putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [Nocardia farcinica IFM 10152] Length=520 Score = 761 bits (1965), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/564 (71%), Positives = 445/564 (79%), Gaps = 46/564 (8%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R K PGRI+FVGSGPGDP LLT RA VL A L FTDPDV + V+ALIGT + P Sbjct 1 MSRATKKHPGRILFVGSGPGDPALLTVRAREVLGRATLAFTDPDVDKGVLALIGTAVEP- 59 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 E G + D+RPALG+PA+VAKTL AEAR G Sbjct 60 ---------------------NEDGTSPV-------DVRPALGEPAEVAKTLIAEARGGH 91 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVR+VAGDPLT D+VI+EV AV R+H+ E++PGL SAVP+YAG+ LGS HT ADVR Sbjct 92 DVVRVVAGDPLTTDSVITEVTAVTRSHMVFEVLPGLPNGSAVPSYAGIALGSGHTEADVR 151 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + DW ALAAAPGPL+L AT+ HLAE+A +L++H +A TP VT GTT QQR++E Sbjct 152 GE---VDWAALAAAPGPLVLHATSGHLAETASALVEHGMAPQTPVAVTVRGTTRQQRTIE 208 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L A GPL+VTIGK V SR+K++WWESRALYGWTVLV Sbjct 209 ATLATLNSAA--------------SELVGPLVVTIGKVVASRSKMSWWESRALYGWTVLV 254 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQA EMSERL ++GA+P+EVPTIAVEPPRSPAQMERAVKGLVDGR+QW+VFTSTNA Sbjct 255 PRTKDQAAEMSERLVTHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNA 314 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGE+TAD+VR+FGI+PELVPSGEQSS GLL DFPP Sbjct 315 VRAVWEKFAEFGLDARAFSGVKIACVGEATADKVRSFGINPELVPSGEQSSEGLLADFPP 374 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD VFDPVNRVLLPRADIATETLAEGLR+RGWEI+DVTAYRTVRA+PPPA TREMIKTGG Sbjct 375 YDDVFDPVNRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRASPPPAETREMIKTGG 434 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAV FTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP+ A +GPLV+ Sbjct 435 FDAVLFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPEVAQVGPLVE 494 Query 541 ALAEHAARLRAEGALPPPRKKSRR 564 ALAEHAARLRAEG LPPPRKKSRR Sbjct 495 ALAEHAARLRAEGLLPPPRKKSRR 518 >gi|226305132|ref|YP_002765090.1| uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Rhodococcus erythropolis PR4] gi|229490637|ref|ZP_04384475.1| uroporphyrinogen-III synthase [Rhodococcus erythropolis SK121] gi|226184247|dbj|BAH32351.1| uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Rhodococcus erythropolis PR4] gi|229322457|gb|EEN88240.1| uroporphyrinogen-III synthase [Rhodococcus erythropolis SK121] Length=520 Score = 758 bits (1957), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/565 (70%), Positives = 449/565 (80%), Gaps = 45/565 (7%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RK PGRI+FVGSGPGDP LLT RA VL AA+ FTDPDV + VVAL+G D+ Sbjct 1 MTRVRKNTPGRILFVGSGPGDPALLTVRARDVLTGAAMAFTDPDVDKGVVALVGIDM--- 57 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 G +E G + D+RPALG+PA+VAKTL EA++G Sbjct 58 ------------------GRDEETGELIA-------DVRPALGEPAEVAKTLVHEAKNGH 92 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLV+GDPLT D+VI+EV AVART + E++PGL + SAVP+YAG+ LGS HT ADVR Sbjct 93 DVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSGSAVPSYAGMALGSGHTEADVR 152 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + DW ALAAAPGPL+L AT+ HLAE+A +L+++ LA TP +T GTT QQR+VE Sbjct 153 GE---VDWAALAAAPGPLVLHATSGHLAETASALVENGLAPQTPAAITVRGTTRQQRTVE 209 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L + G LIVT+GK V R K++WWESRALYGWTVLV Sbjct 210 ATLATLNEAG--------------SELVGSLIVTVGKVVAQRNKMSWWESRALYGWTVLV 255 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QW+VFTSTNA Sbjct 256 PRTKDQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNA 315 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PEL+P+GEQSS GLL +F P Sbjct 316 VRAVWEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELIPTGEQSSEGLLAEFAP 375 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 376 YDDVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGG 435 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQP+T+ +GPLV+ Sbjct 436 FDAVCFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETSQVGPLVE 495 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSRRR Sbjct 496 ALAEHAARLRAEGALPPPRKKSRRR 520 >gi|343925964|ref|ZP_08765479.1| uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Gordonia alkanivorans NBRC 16433] gi|343764315|dbj|GAA12405.1| uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Gordonia alkanivorans NBRC 16433] Length=560 Score = 756 bits (1953), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/576 (69%), Positives = 460/576 (80%), Gaps = 31/576 (5%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R +K PGRI+FVGSGPGDP LLT RA V+ NA + DPDVP VV+LIG+ Sbjct 1 MSRTKKANPGRILFVGSGPGDPDLLTVRARTVIINATTAYIDPDVPAAVVSLIGS--AHR 58 Query 61 SGPAP------------AEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADV 108 PAP AE A DAA +A + A + +RPALGDP +V Sbjct 59 EEPAPNTRRSTKKADKTAEDKADGTDAADTAAAADASAAEADKADEESVVRPALGDPTEV 118 Query 109 AKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGL 168 AKTL A AR+G DVVR+VAGDPLT D+V++EVNAVAR + E++PGL A+S VP+YAG+ Sbjct 119 AKTLVAAARNGDDVVRVVAGDPLTTDSVLAEVNAVARHSVTFEVLPGLPAASVVPSYAGM 178 Query 169 PLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVT 228 PLGS+HT ADVR + DW ALAAAPGPL+L AT+ HLAE+A +L +H +A TP +T Sbjct 179 PLGSTHTEADVRGE---VDWAALAAAPGPLVLHATSGHLAETASALTEHGMAPQTPAAIT 235 Query 229 AHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWW 288 +GTTC QR++E TL L + ++ GPL+VT+GK V SR++L+WW Sbjct 236 INGTTCAQRTIEATLATLNEQG--------------NALTGPLVVTVGKVVGSRSRLSWW 281 Query 289 ESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDG 348 ESR+LYGWTVLVPRTKDQAG+MS+RL S+GA+P EVPTIAVEPPRSPAQMERAVKGLVDG Sbjct 282 ESRSLYGWTVLVPRTKDQAGDMSDRLVSHGAIPKEVPTIAVEPPRSPAQMERAVKGLVDG 341 Query 349 RFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGE 408 R+QW+VFTSTN+VRAVWEKF EFGLDARAFSGVKIACVGE+TAD+VR+FGI+PELVPSGE Sbjct 342 RYQWVVFTSTNSVRAVWEKFAEFGLDARAFSGVKIACVGEATADKVRSFGINPELVPSGE 401 Query 409 QSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPP 468 QSSLGLLD+FPPYD VFDPVNR+LLPRADIATETL+EGLR+RGWEI+DVTAYRTVRAAPP Sbjct 402 QSSLGLLDEFPPYDDVFDPVNRILLPRADIATETLSEGLRDRGWEIDDVTAYRTVRAAPP 461 Query 469 PATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDV 528 PA TREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDV Sbjct 462 PAETREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETATEFGLRVDV 521 Query 529 QPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRR 564 QP+ A++ LVDALAEHAARLRAEGALPPPRKKSRR Sbjct 522 QPENASVLELVDALAEHAARLRAEGALPPPRKKSRR 557 >gi|111019044|ref|YP_702016.1| uroporphiryn-III C-methyltransferase [Rhodococcus jostii RHA1] gi|110818574|gb|ABG93858.1| probable uroporphiryn-III C-methyltransferase [Rhodococcus jostii RHA1] Length=521 Score = 753 bits (1943), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/565 (70%), Positives = 445/565 (79%), Gaps = 45/565 (7%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R RK PGRI+FVGSGPGDP LLT A VLA A L FTDPDV + V L+GTDL Sbjct 1 MSRVRKNTPGRILFVGSGPGDPALLTVHARDVLAAATLAFTDPDVDKGVTVLVGTDL--- 57 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 G E G + ++RPALG+PA+VAKTL EAR+G Sbjct 58 ------------------GVDAETGEPLA-------EVRPALGEPAEVAKTLVHEARNGH 92 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLV+GDPLT D+VI+EV AVART + E++PGL ++SAVP+YAG+ LGS HT ADVR Sbjct 93 DVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSASAVPSYAGMALGSGHTEADVR 152 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + DW ALAAAPGPL+L AT+ HLAE+A +L++H LA TP +T GTT QQR+VE Sbjct 153 GE---VDWAALAAAPGPLVLHATSGHLAETASALVEHGLAPQTPAAITVRGTTRQQRTVE 209 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L + G L+VT+GK V R K++WWESRALYGW VLV Sbjct 210 ATLATLNEAG--------------SELVGSLVVTVGKVVAQRNKMSWWESRALYGWKVLV 255 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QW+VFTSTNA Sbjct 256 PRTKDQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNA 315 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PELVPSGEQSS GLL +F P Sbjct 316 VRAVWEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAEFAP 375 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 376 YDDVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGG 435 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQP+TA +GPLV+ Sbjct 436 FDAVCFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETAQVGPLVE 495 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSR R Sbjct 496 ALAEHAARLRAEGALPPPRKKSRAR 520 >gi|226361137|ref|YP_002778915.1| uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Rhodococcus opacus B4] gi|226239622|dbj|BAH49970.1| putative uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase [Rhodococcus opacus B4] Length=521 Score = 752 bits (1942), Expect = 0.0, Method: Compositional matrix adjust. Identities = 390/565 (70%), Positives = 445/565 (79%), Gaps = 45/565 (7%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R RK PGRI+FVGSGPGDP LLT A VLA A L FTDPDV + V L+GTDL Sbjct 1 MSRVRKNTPGRILFVGSGPGDPALLTVHARDVLAAATLAFTDPDVDKGVTVLVGTDL--- 57 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 G E G + ++RPALG+PA+VAKTL EA++G Sbjct 58 ------------------GVDAETGEPLA-------EVRPALGEPAEVAKTLVHEAKNGH 92 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLV+GDPLT D+VI+EV AVART + E++PGL ++SAVP+YAG+ LGS HT ADVR Sbjct 93 DVVRLVSGDPLTTDSVIAEVTAVARTQVQFEVLPGLPSASAVPSYAGMALGSGHTEADVR 152 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + DW ALAAAPGPL+L AT+ HLAE+A +L++H LA TP +T GTT QQR+VE Sbjct 153 GE---VDWAALAAAPGPLVLHATSGHLAETASALVEHGLAPQTPAAITVRGTTRQQRTVE 209 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L + G L+VT+GK V R K++WWESRALYGW VLV Sbjct 210 ATLATLNEAG--------------SELVGSLVVTVGKVVAQRNKMSWWESRALYGWKVLV 255 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMS+RL ++GA+P+EVPTIAVEPPRSPAQMER+VKGLVDGR+QW+VFTSTNA Sbjct 256 PRTKDQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNA 315 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIAC+GE+TA +VR+FGI+PELVPSGEQSS GLL +F P Sbjct 316 VRAVWEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAEFAP 375 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD VFDPVNRVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 376 YDDVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGG 435 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDVQP+TA +GPLV+ Sbjct 436 FDAVCFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETAIEFGLRVDVQPETAQVGPLVE 495 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRKKSR R Sbjct 496 ALAEHAARLRAEGALPPPRKKSRAR 520 >gi|326383044|ref|ZP_08204733.1| uroporphyrin-III C-methyltransferase HemD [Gordonia neofelifaecis NRRL B-59395] gi|326198180|gb|EGD55365.1| uroporphyrin-III C-methyltransferase HemD [Gordonia neofelifaecis NRRL B-59395] Length=535 Score = 741 bits (1913), Expect = 0.0, Method: Compositional matrix adjust. Identities = 386/564 (69%), Positives = 448/564 (80%), Gaps = 32/564 (5%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R + PGRI+FVGSGPG+P LLT RA VL NA + DPDVP V+A+IG Sbjct 1 MSRTKNANPGRILFVGSGPGNPDLLTVRAQDVLVNATSAYVDPDVPAGVIAVIG------ 54 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 S A AEP AG +A E A V +PALGDP+ VAKTL AEA++G Sbjct 55 SAHASAEPAPTR---AGRKAAAEQAVDAPEVT------KPALGDPSQVAKTLVAEAKTGT 105 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 +VVR+VAGDP++ DAV++EV AVART + E++PG+ A+SAVP++AG+PLGS HTVADVR Sbjct 106 NVVRVVAGDPMSSDAVLAEVTAVARTSVPFEVLPGIPAASAVPSFAGMPLGSGHTVADVR 165 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW ALAAAPGPL+L AT+ HLAE A L +H LA TP +T +GTTC QR++E Sbjct 166 GD---VDWAALAAAPGPLVLHATSGHLAELASELTEHGLAPQTPVAITVNGTTCAQRTIE 222 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL + + NG ++ GPL+VT+GK V R K +WWESRALYGWTVLV Sbjct 223 ATLATVNE-------------NG-NALTGPLVVTVGKIVGQRGKFSWWESRALYGWTVLV 268 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQA +MSERL S+GA+P EVPTIAVEPPRSPAQMER+VKGLVDGR+QW+VFTSTNA Sbjct 269 PRTKDQAVDMSERLVSHGAIPKEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNA 328 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGE TA +VR+FG+ PEL+P+GEQSSLGLL+ FPP Sbjct 329 VRAVWEKFAEFGLDARAFSGVKIACVGEGTAAKVRSFGVEPELLPTGEQSSLGLLEVFPP 388 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD VFDPV+R+LLPRADIATETL+EGLR+RGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 389 YDEVFDPVDRILLPRADIATETLSEGLRDRGWEIDDVTAYRTVRAAPPPAETREMIKTGG 448 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTI+ACIGPKTAETA EFGLRVDVQP++A+I LVD Sbjct 449 FDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPESASIVDLVD 508 Query 541 ALAEHAARLRAEGALPPPRKKSRR 564 ALA HA +LRAEGALPPPRKKSRR Sbjct 509 ALAAHAEQLRAEGALPPPRKKSRR 532 >gi|296138402|ref|YP_003645645.1| uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Tsukamurella paurometabola DSM 20162] gi|296026536|gb|ADG77306.1| Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Tsukamurella paurometabola DSM 20162] Length=567 Score = 735 bits (1897), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/562 (67%), Positives = 446/562 (80%), Gaps = 26/562 (4%) Query 3 RGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSG 62 RG+ PGRI FVGSGPGDPGLLT RA +A A V+TDPDVP V+ ++G +LP Sbjct 29 RGKATAPGRITFVGSGPGDPGLLTLRAQQTIAQARTVYTDPDVPATVLEMVGAELP---- 84 Query 63 PAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDV 122 EP+ DA + GR A + PALG+PA+VAKTL +AR G DV Sbjct 85 ---VEPI--ETDADAPAAEPAKGRKAEPAFRNPATVAPALGEPAEVAKTLLTQARHGQDV 139 Query 123 VRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRID 182 VRLVAGDP++ DAV++E++AVART + E++PGL+ ++AVP YAG+ LGS+HTVADVR + Sbjct 140 VRLVAGDPMSSDAVLAEIHAVARTQIAFEVIPGLSTATAVPAYAGMALGSAHTVADVRGE 199 Query 183 PENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETT 242 DW ALAAAP PL+L ATA HLA++A +L+++ LA TP VT G+TC+Q++++ T Sbjct 200 ---VDWAALAAAPSPLVLGATAEHLADAASALVENGLAPQTPVAVTTQGSTCKQKTLDAT 256 Query 243 LQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPR 302 L L + A GPL++T+GK V +R+KL+WWESRALYGWTVLVPR Sbjct 257 LATLNEVAA--------------GLPGPLVITVGKVVGTRSKLSWWESRALYGWTVLVPR 302 Query 303 TKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVR 362 TKDQA +MS RL +GA+P+EVPTIAVEPPRSPAQMERAVKGLVDGR+QW+VFTSTNAVR Sbjct 303 TKDQAADMSNRLRGHGAIPMEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVR 362 Query 363 AVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYD 422 AVWEKF EFGLDARAFSGVKIACVGE TA +VRAFGI PEL+P+GEQSSLG+L+ FPP+D Sbjct 363 AVWEKFTEFGLDARAFSGVKIACVGEQTAAKVRAFGIEPELLPTGEQSSLGMLEVFPPFD 422 Query 423 SVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFD 482 VFDPVNRVLLPRADIATETLAEGLR+RGWEI+DVTAYRTVRAAPPPA+TREMIKTG FD Sbjct 423 DVFDPVNRVLLPRADIATETLAEGLRDRGWEIDDVTAYRTVRAAPPPASTREMIKTGDFD 482 Query 483 AVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDAL 542 AVCFTSSSTVRNLVGIAGKPH+RTI+ACIGPKTAETA EFGLRVDVQP+TA++ LV+AL Sbjct 483 AVCFTSSSTVRNLVGIAGKPHSRTIVACIGPKTAETAIEFGLRVDVQPETASVEDLVEAL 542 Query 543 AEHAARLRAEGALPPPRKKSRR 564 A HA+RLRAEG LPPPRKK RR Sbjct 543 AAHASRLRAEGTLPPPRKKPRR 564 >gi|467061|gb|AAA17245.1| cysG [Mycobacterium leprae] Length=472 Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust. Identities = 389/464 (84%), Positives = 410/464 (89%), Gaps = 10/464 (2%) Query 2 TRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVS 61 TRGRK RPGRI FVG+GPG PGLLT +A AVLANAALVF DPDVPEPV+ALIG DLPPVS Sbjct 8 TRGRKLRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKDLPPVS 67 Query 62 GPAPAEPVAGN-GDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 GPAPA P A G AA G +H +AA V+SGG DIRPALGDP +VAKTLTAEARSGV Sbjct 68 GPAPAGPAAVTAGRAADGTLEGDHYQAAPMVMSGGADIRPALGDPTEVAKTLTAEARSGV 127 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDPLTVDAVI+EVNAVART+L IEIVPGL SS VPTYAGLPLGSSHTVADVR Sbjct 128 DVVRLVAGDPLTVDAVIAEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVR 187 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW+ALAAAPGPLILQATASHLA++A LIDH L ++TPCVVTA GTTCQQRSVE Sbjct 188 GD---VDWEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQRSVE 244 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTL+GL D AVL TD A G PL+VTIGKTVTSRA+LNWWESRALYGWTVLV Sbjct 245 TTLEGLADSAVLVGTDTAGPLTG------PLVVTIGKTVTSRARLNWWESRALYGWTVLV 298 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQW+VFTSTNA Sbjct 299 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNA 358 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKFGEFGLDARAFSGVKIACVGE+TADRVRAFGISPELVP+GEQSSLGLLD+FPP Sbjct 359 VRAVWEKFGEFGLDARAFSGVKIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPP 418 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVR 464 YDSVFDPVNRVLLPRADIATETLAEGLR GWEIEDVTAYRTVR Sbjct 419 YDSVFDPVNRVLLPRADIATETLAEGLRGCGWEIEDVTAYRTVR 462 >gi|333918316|ref|YP_004491897.1| putative uroporphiryn-III C-methyltransferase [Amycolicicoccus subflavus DQS3-9A1] gi|333480537|gb|AEF39097.1| putative uroporphiryn-III C-methyltransferase [Amycolicicoccus subflavus DQS3-9A1] Length=519 Score = 703 bits (1815), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/565 (67%), Positives = 443/565 (79%), Gaps = 47/565 (8%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 M+R K PGRI+FVGSGPGDP LLT RA VL ++ FTD DV + V L+GT + Sbjct 1 MSRAHKSTPGRILFVGSGPGDPALLTLRAKQVLETTSIAFTDADVSDAVAKLVGTCI--- 57 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 +++ G A S ++RPALG+P++VAKTL AEAR G Sbjct 58 --------------------SEDEGDATS-------EVRPALGEPSEVAKTLIAEARKGH 90 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLV+GDP+T D+V++E+ AVART + E+VPGLA ++A+P YAG+PLG+ HT ADVR Sbjct 91 DVVRLVSGDPMTTDSVLAEITAVARTQVQFEVVPGLAPAAAIPAYAGMPLGAGHTEADVR 150 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW ALAAAPGPL+L AT+SHLAE A +L++H LA TP +T GTTC+QR++E Sbjct 151 GD---VDWAALAAAPGPLVLHATSSHLAEMASALVEHGLAPQTPAAITVFGTTCRQRTIE 207 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L +A+G + G L+VT+GK V +R K++WWE+R LYGWTVLV Sbjct 208 ATLATL-------------NASGSE-LTGSLVVTVGKVVEARGKMSWWENRDLYGWTVLV 253 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK QAGEMS+RL SYGA+P+EVPTI+VEPPRSPAQMERAVKGLVDGR+QW+VFTSTNA Sbjct 254 PRTKQQAGEMSDRLVSYGAIPIEVPTISVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNA 313 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 V+AVWEKF EFGLDARAFSGVKIACVGE+TA++VR+FGI+PELVPSGEQSS GLL DFPP Sbjct 314 VKAVWEKFEEFGLDARAFSGVKIACVGEATAEKVRSFGITPELVPSGEQSSQGLLADFPP 373 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 +D + DPV+RVLLPRADIATETL+EGLRERGWEI+DVTAYRTVRA+PP A REMIKTGG Sbjct 374 HDDILDPVDRVLLPRADIATETLSEGLRERGWEIDDVTAYRTVRASPPAAEIREMIKTGG 433 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAV FTSSSTVRNLVGIAGKPH RTI+ACIGPKTAETAAEFGLRVDVQPD A +GPLVD Sbjct 434 FDAVLFTSSSTVRNLVGIAGKPHQRTIVACIGPKTAETAAEFGLRVDVQPDVAQVGPLVD 493 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALA HAA LRAEG LPPPRK+SR R Sbjct 494 ALAAHAAHLRAEGLLPPPRKRSRAR 518 >gi|256380711|ref|YP_003104371.1| uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Actinosynnema mirum DSM 43827] gi|255925014|gb|ACU40525.1| Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Actinosynnema mirum DSM 43827] Length=510 Score = 701 bits (1808), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/565 (66%), Positives = 424/565 (76%), Gaps = 57/565 (10%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RK PGR+ FVGSGPGD GLLT RA +L A LV TDPDVP VVAL Sbjct 1 MTRARK-TPGRVAFVGSGPGDTGLLTVRARDLLGKAELVVTDPDVPAEVVAL-------- 51 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 V G ++RPA+G+PADVAK L AEA++G Sbjct 52 -------------------------------VPDGVEVRPAVGEPADVAKDLVAEAKNGA 80 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 VVRLVAGDPLT+D+V+ E +AV++T + ++VPG+ A +AVP YAG+ LG+ HT ADVR Sbjct 81 AVVRLVAGDPLTLDSVVKEAHAVSKTTIAFDVVPGVPAGTAVPAYAGVALGAVHTEADVR 140 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 DW LA+A G L+L AT HLAE+A SL++H LA TP VTA GT QR+V+ Sbjct 141 ---GAVDWAGLASATGTLVLHATGGHLAEAASSLVEHGLAPQTPVAVTADGTGFSQRTVD 197 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTL L A +GPL+VT+G V +R KL+WWESRALYGW VLV Sbjct 198 TTLASLAADA--------------GELSGPLVVTVGSAVANRPKLSWWESRALYGWRVLV 243 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK+QAG MS+RL S+GA+PVEVPTI+VEPPRSPAQMER+VKGLVDGR+QW+VFTSTNA Sbjct 244 PRTKEQAGAMSDRLHSHGAIPVEVPTISVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNA 303 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGE+TA +VR FGI PELVPSGEQSS GLL DFPP Sbjct 304 VRAVWEKFREFGLDARAFSGVKIACVGEATAAKVRGFGIIPELVPSGEQSSEGLLADFPP 363 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD + DPV+RVLLPRADIATETLA GLR+RGWEI+DVTAYRTVRAAPPPA TREMIK+GG Sbjct 364 YDDILDPVDRVLLPRADIATETLAAGLRDRGWEIDDVTAYRTVRAAPPPADTREMIKSGG 423 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART++ACIGP+TAETA EFGLRVDVQP+ A + LVD Sbjct 424 FDAVCFTSSSTVRNLVGIAGKPHARTLVACIGPQTAETAREFGLRVDVQPEDANVPALVD 483 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALA+HAARLRAEGALPPPRK R R Sbjct 484 ALAQHAARLRAEGALPPPRKTKRLR 508 >gi|134103371|ref|YP_001109032.1| uroporphyrinogen III synthase/methyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|133915994|emb|CAM06107.1| uroporphyrinogen III synthase/methyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=510 Score = 696 bits (1796), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/565 (66%), Positives = 421/565 (75%), Gaps = 57/565 (10%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RK PGRI FVGSGPGD GLLT RA V+ +A+LV TDPDVP +V L Sbjct 1 MTRARK-TPGRIAFVGSGPGDAGLLTVRARHVITSASLVVTDPDVPADIVGL-------- 51 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 + G ++RPA+GDPADVA L EA++G Sbjct 52 -------------------------------AAEGAEVRPAVGDPADVALDLANEAKTGR 80 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 VVRLVAGDPLT DAV+ EV AVA+T + +IVPG+ A SAVP YAG+ LG+ H DVR Sbjct 81 PVVRLVAGDPLTADAVVREVQAVAKTDVAFDIVPGVPAGSAVPAYAGVALGAVHAEVDVR 140 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW +LA PG L+L +HLAE+A +L++H A TP VTA GTT QQR+++ Sbjct 141 GD---VDWASLAKVPGALVLHTAGTHLAEAASALVEHGRAAQTPVAVTASGTTVQQRTID 197 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTL L +A+ + Q G L+VTIG V+ R L+WWESRALYGW VLV Sbjct 198 TTLASL-------------AADAGELQ-GQLVVTIGDVVSERNSLSWWESRALYGWKVLV 243 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK+QAG MSERL S+GA+ EVPTI+VEPPRSPAQMERAVKGLVDGR+QW+VFTSTNA Sbjct 244 PRTKEQAGSMSERLWSHGAVSHEVPTISVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNA 303 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGE+TA++VR+FGI+PELVPSGEQSS GLL DFPP Sbjct 304 VRAVWEKFREFGLDARAFSGVKIACVGEATAEKVRSFGINPELVPSGEQSSEGLLQDFPP 363 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 +D + DPV+RVLLPRADIATETLA GLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 364 HDDILDPVDRVLLPRADIATETLAAGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGG 423 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTS+STVRNLVGIAGKPHART++ACIGP TAETA EFGLRVDVQP+ I LVD Sbjct 424 FDAVCFTSASTVRNLVGIAGKPHARTLVACIGPSTAETAKEFGLRVDVQPEVPQIPVLVD 483 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPP+K R R Sbjct 484 ALAEHAARLRAEGALPPPKKAKRAR 508 >gi|257054364|ref|YP_003132196.1| uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase [Saccharomonospora viridis DSM 43017] gi|256584236|gb|ACU95369.1| uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase [Saccharomonospora viridis DSM 43017] Length=516 Score = 679 bits (1752), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/565 (63%), Positives = 417/565 (74%), Gaps = 56/565 (9%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RK GR+ FVGSGPGD GLLT RA +LA A LV TDPDVP V+A G + Sbjct 1 MTRARKTT-GRVAFVGSGPGDAGLLTVRARDLLAKADLVVTDPDVPAGVLAYAGPE---- 55 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 ++RPA+G+P DVAK L EA++G Sbjct 56 -----------------------------------AEVRPAVGEPGDVAKDLATEAKAGR 80 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 V+RL +GDPLT AVI+EV AV+RT+ ++VPG+ A +A P YAG+ LG T D+R Sbjct 81 LVLRLTSGDPLTQQAVIAEVQAVSRTNAVFDVVPGVPAGTATPAYAGIALGGVRTEVDLR 140 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 DW LA+APG ++L AT+SHLAE+A +L++H +++ TP VT++GT QR+++ Sbjct 141 SG--EVDWAKLASAPGAIVLHATSSHLAEAASALVEHGMSDQTPVAVTSNGTINTQRTLD 198 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 +TL L A GPL+VTIG+ V++R KL+WWESRALYGW VLV Sbjct 199 STLASLAADA--------------GELVGPLVVTIGEPVSNRQKLSWWESRALYGWKVLV 244 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK+QAG+M+ER+ S+GA P EVPTI+VEPPRSPAQMERAVKGLVDGR+QW+VFTS NA Sbjct 245 PRTKEQAGDMAERILSHGATPHEVPTISVEPPRSPAQMERAVKGLVDGRYQWLVFTSANA 304 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGE+TADRVR+FGI PELVP GEQSS GLL +FPP Sbjct 305 VRAVWEKFNEFGLDARAFSGVKIACVGEATADRVRSFGIIPELVPKGEQSSEGLLQEFPP 364 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD V DPVNRVLLPRADIATE L+ GL+ERGWE++DVTAYRTVRAAPPPA TREMIKTGG Sbjct 365 YDDVLDPVNRVLLPRADIATEILSAGLQERGWEVDDVTAYRTVRAAPPPAETREMIKTGG 424 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART++ACIGPKTAETA EFGLRVDV+P+ LVD Sbjct 425 FDAVCFTSSSTVRNLVGIAGKPHARTLVACIGPKTAETATEFGLRVDVRPEQPNAVMLVD 484 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAA+LRAEGALPPPRK R R Sbjct 485 ALAEHAAKLRAEGALPPPRKAKRTR 509 >gi|296394052|ref|YP_003658936.1| uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Segniliparus rotundus DSM 44985] gi|296181199|gb|ADG98105.1| Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Segniliparus rotundus DSM 44985] Length=526 Score = 672 bits (1733), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/555 (64%), Positives = 414/555 (75%), Gaps = 48/555 (8%) Query 5 RKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPA 64 +K GR+VFVG+GPGDPGLL RA L A++VF DP VP +++LIGT Sbjct 3 KKKTAGRVVFVGAGPGDPGLLAWRARETLIAASVVFADPGVPREILSLIGTR-------- 54 Query 65 PAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPD----IRPALGDPADVAKTLTAEARSGV 120 S E G+ S PD + P D +DV K L EA++G Sbjct 55 --------------SSVDEEGQTLSK-----PDPLVTVLPEEIDSSDVVKMLLNEAKNGN 95 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLVAGDP + + V+ E+ A++R+ ++++PG++A++A P YAG+PLGS HT AD+R Sbjct 96 DVVRLVAGDPGSSEEVVGELLAISRSQAPMDVIPGVSATAAAPLYAGIPLGSIHTEADLR 155 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW ALA+APG L+L TA LA + +LID L +TP +T+ GTT Q+++E Sbjct 156 GD---VDWSALASAPGSLVLSLTAKQLAPTGAALIDQGLPPNTPVAITSAGTTRTQKTLE 212 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 +TL GL+ +GA PA PL++T+G+ V R+KLNWWESRAL+ W+VLV Sbjct 213 STLSGLSQ---MGAELPA-----------PLVLTVGRVVGQRSKLNWWESRALFSWSVLV 258 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTKDQAGEM ERL S+GA+PVEVPTIAVEP RSPAQMERAVKGLVDGR+QW+VFTSTNA Sbjct 259 PRTKDQAGEMCERLVSHGAIPVEVPTIAVEPARSPAQMERAVKGLVDGRYQWVVFTSTNA 318 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVG +TA RVR FGI PELVP GEQSSLGLLD+FPP Sbjct 319 VRAVWEKFNEFGLDARAFSGVKIACVGPATAKRVREFGIEPELVPEGEQSSLGLLDEFPP 378 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD +FDPVNRVLLPRADIATETL GLR+ GWE++DVTAYRTVRAAPPPA REMIKTGG Sbjct 379 YDEIFDPVNRVLLPRADIATETLTAGLRDGGWEVDDVTAYRTVRAAPPPAEIREMIKTGG 438 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKT ETA EFGLRVDVQP+ A+ LVD Sbjct 439 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTVETAQEFGLRVDVQPEVASAPALVD 498 Query 541 ALAEHAARLRAEGAL 555 ALAEHAARLRAEGAL Sbjct 499 ALAEHAARLRAEGAL 513 >gi|319949782|ref|ZP_08023806.1| uroporphyrin-III C-methyltransferase HemD [Dietzia cinnamea P4] gi|319436541|gb|EFV91637.1| uroporphyrin-III C-methyltransferase HemD [Dietzia cinnamea P4] Length=537 Score = 669 bits (1726), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/555 (64%), Positives = 407/555 (74%), Gaps = 18/555 (3%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR R RPG + FVG GPG+ G+LT RA VLA ALVF D DV V+AL+ T++P Sbjct 1 MTRARTTRPGTVRFVGGGPGNAGMLTCRAREVLAGNALVFADADVSADVLALVATEVPVP 60 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 A + A A E R + D+RP LG+PA VAK L AEA+ G Sbjct 61 QELLDARQAEMDAAVAAEDKA-EVKRLKALPAPTAADVRPVLGEPAAVAKQLVAEAKKGR 119 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 DVVRLV GDP+T DA ++E+ AV RT + E+VPG+A ++AVP +AG+ LGS + AD R Sbjct 120 DVVRLVTGDPMTTDATVTEIAAVGRTVVPFEVVPGVAEATAVPAFAGIALGSGYVFADGR 179 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 DW+AL +PGP++L+ T HLAE+A +L + LA TP VT G+ C Q+S + Sbjct 180 ---GKVDWEALVGSPGPIVLRTTTRHLAEAASNLAEQGLAAGTPVTVTCSGSLCAQKSAD 236 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL + + GRD + G L+VTIGK+ R + WWESRA++GW VLV Sbjct 237 GTLATMAE-------------VGRDME-GDLVVTIGKSAGERHRYQWWESRAMFGWNVLV 282 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK Q+ EMSER+ +GA+PVEVPTIAVEPPRSPAQMERAVKGLVDGR+QW+VFTS+NA Sbjct 283 PRTKAQSAEMSERIAEHGAVPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSSNA 342 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGE TA RVR GI PEL+PSGEQSSLGLL+ FPP Sbjct 343 VRAVWEKFVEFGLDARAFSGVKIACVGEGTAARVRELGIQPELLPSGEQSSLGLLEVFPP 402 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD V DPVNRVLLPRADIATETLAEGL RGWEIEDVTAYRTVRAAPP A REMIKTGG Sbjct 403 YDDVLDPVNRVLLPRADIATETLAEGLTARGWEIEDVTAYRTVRAAPPAAEIREMIKTGG 462 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHART+IACIGP+TAETAAEFGLRVDVQP+ A++ LVD Sbjct 463 FDAVCFTSSSTVRNLVGIAGKPHARTLIACIGPRTAETAAEFGLRVDVQPENASVLELVD 522 Query 541 ALAEHAARLRAEGAL 555 ALA HA LRA G L Sbjct 523 ALAAHADHLRAAGEL 537 >gi|302523840|ref|ZP_07276182.1| uroporphyrinogen III synthase/methyltransferase [Streptomyces sp. AA4] gi|302432735|gb|EFL04551.1| uroporphyrinogen III synthase/methyltransferase [Streptomyces sp. AA4] Length=510 Score = 669 bits (1725), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/565 (64%), Positives = 418/565 (74%), Gaps = 57/565 (10%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MT RK GR+ FVGSGPGD GLLT RA +LA A +V TDPDVP V+A D Sbjct 1 MTPARK-TAGRVAFVGSGPGDAGLLTVRAQELLAKAEVVVTDPDVPASVLAFASPDA--- 56 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 ++RPA+G+P+DVAK LTAEA++G Sbjct 57 ------------------------------------EVRPAVGEPSDVAKDLTAEAKAGR 80 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 +RLV+GDPLT AV++EV AVART +++PG+A +AVP YAG+ LG ++T ADVR Sbjct 81 LALRLVSGDPLTSPAVVAEVQAVARTSAVFDVIPGVAPGTAVPAYAGVALGGTYTEADVR 140 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 + DW ALAA PGP++L AT++HLAE+A L + LA +TP VTA+GT QR+++ Sbjct 141 GE---VDWGALAAVPGPIVLHATSAHLAEAASQLTEKGLAPTTPVAVTANGTINTQRTLD 197 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTL A AN GPL+VT+G+ R+KL+WWESRALYGW VLV Sbjct 198 TTL--------------ASVANDAGELVGPLVVTVGQAAGQRSKLSWWESRALYGWKVLV 243 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK+QAGEM+ERL +GA EVPTI+VEPPRSPAQMER+VKGLVDGR+QWIVFTSTNA Sbjct 244 PRTKEQAGEMAERLRGHGATSHEVPTISVEPPRSPAQMERSVKGLVDGRYQWIVFTSTNA 303 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGESTA +VR+FGI PELVP+GEQSS GLL +FPP Sbjct 304 VRAVWEKFEEFGLDARAFSGVKIACVGESTAAKVRSFGIIPELVPTGEQSSEGLLAEFPP 363 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD V DPVNRVLLPRADIATE L+ GL ERGWE++DVTAYRTVRAAPPPA TREMIKTGG Sbjct 364 YDDVLDPVNRVLLPRADIATEILSAGLVERGWEVDDVTAYRTVRAAPPPAETREMIKTGG 423 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPH RT++ACIGPKTAETA EFGLRVDVQP+ A + LVD Sbjct 424 FDAVCFTSSSTVRNLVGIAGKPHTRTLVACIGPKTAETAVEFGLRVDVQPEKADVPHLVD 483 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRK R R Sbjct 484 ALAEHAARLRAEGALPPPRKAKRTR 508 >gi|300782414|ref|YP_003762705.1| uroporphyrinogen-III synthase [Amycolatopsis mediterranei U32] gi|299791928|gb|ADJ42303.1| uroporphyrinogen-III synthase [Amycolatopsis mediterranei U32] gi|340523782|gb|AEK38987.1| uroporphyrin-III C-methyltransferase HemD [Amycolatopsis mediterranei S699] Length=510 Score = 664 bits (1712), Expect = 0.0, Method: Compositional matrix adjust. Identities = 362/565 (65%), Positives = 422/565 (75%), Gaps = 57/565 (10%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MT RK GR+ FVGSGPGD GLLT RA +L A +V TDPDVP+ V+A+ Sbjct 1 MTPARKTT-GRVAFVGSGPGDAGLLTVRAQELLTKAEVVVTDPDVPQSVLAM-------- 51 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 + G ++RPA+G+ +VAK LT EA++G Sbjct 52 -------------------------------AAEGAEVRPAVGEATEVAKDLTTEAKAGR 80 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 V+RLVAGDPLT AV++EV AVART +++PG++ ++AVP YAG+ LG +HT DVR Sbjct 81 LVLRLVAGDPLTTPAVVAEVQAVARTSAVFDVIPGVSPAAAVPAYAGVALGGTHTEVDVR 140 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 D DW ALAAAPGPL+L AT++HLAE+A +L + + STP VTA+GT QR+++ Sbjct 141 GD---VDWAALAAAPGPLVLHATSAHLAEAASALTGNGVPASTPVAVTANGTINTQRTLD 197 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TTL+ + AN GPLIVTIG+ R+KL+WWESR+LYGW VLV Sbjct 198 TTLEKV--------------ANDAGELVGPLIVTIGQAAGQRSKLSWWESRSLYGWKVLV 243 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 PRTK+QAGEM+ERL +GA EVPTI+VEPPRSPAQMER+VKGLVDGR+QWIVFTSTNA Sbjct 244 PRTKEQAGEMAERLRGHGATSHEVPTISVEPPRSPAQMERSVKGLVDGRYQWIVFTSTNA 303 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGVKIACVGESTA +VR+FGI PEL+PSGEQSS GLL +FPP Sbjct 304 VRAVWEKFEEFGLDARAFSGVKIACVGESTAAKVRSFGIIPELIPSGEQSSEGLLAEFPP 363 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD V DPV+RVLLPRADIATETL+ GLRERGWEI+DVTAYRTVRAAPPPA TREMIKTGG Sbjct 364 YDDVLDPVDRVLLPRADIATETLSAGLRERGWEIDDVTAYRTVRAAPPPAETREMIKTGG 423 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPH RT++ACIGPKTAETA EFGLRVDVQP+ A + LVD Sbjct 424 FDAVCFTSSSTVRNLVGIAGKPHTRTLVACIGPKTAETAVEFGLRVDVQPEKADVPHLVD 483 Query 541 ALAEHAARLRAEGALPPPRKKSRRR 565 ALAEHAARLRAEGALPPPRK R R Sbjct 484 ALAEHAARLRAEGALPPPRKAKRAR 508 >gi|291004410|ref|ZP_06562383.1| uroporphyrinogen III synthase/methyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=480 Score = 656 bits (1693), Expect = 0.0, Method: Compositional matrix adjust. Identities = 344/534 (65%), Positives = 398/534 (75%), Gaps = 56/534 (10%) Query 32 VLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAV 91 ++ +A+LV TDPDVP +V L Sbjct 1 MITSASLVVTDPDVPADIVGL--------------------------------------- 21 Query 92 VSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIE 151 + G ++RPA+GDPADVA L EA++G VVRLVAGDPLT DAV+ EV AVA+T + + Sbjct 22 AAEGAEVRPAVGDPADVALDLANEAKTGRPVVRLVAGDPLTADAVVREVQAVAKTDVAFD 81 Query 152 IVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAAPGPLILQATASHLAESA 211 IVPG+ A SAVP YAG+ LG+ H DVR D DW +LA PG L+L +HLAE+A Sbjct 82 IVPGVPAGSAVPAYAGVALGAVHAEVDVRGD---VDWASLAKVPGALVLHTAGTHLAEAA 138 Query 212 RSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPL 271 +L++H A TP VTA GTT QQR+++TTL L +A+ + Q G L Sbjct 139 SALVEHGRAAQTPVAVTASGTTVQQRTIDTTLASL-------------AADAGELQ-GQL 184 Query 272 IVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP 331 +VTIG V+ R L+WWESRALYGW VLVPRTK+QAG MSERL S+GA+ EVPTI+VEP Sbjct 185 VVTIGDVVSERNSLSWWESRALYGWKVLVPRTKEQAGSMSERLWSHGAVSHEVPTISVEP 244 Query 332 PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTA 391 PRSPAQMERAVKGLVDGR+QW+VFTSTNAVRAVWEKF EFGLDARAFSGVKIACVGE+TA Sbjct 245 PRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFREFGLDARAFSGVKIACVGEATA 304 Query 392 DRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERG 451 ++VR+FGI+PELVPSGEQSS GLL DFPP+D + DPV+RVLLPRADIATETLA GLRERG Sbjct 305 EKVRSFGINPELVPSGEQSSEGLLQDFPPHDDILDPVDRVLLPRADIATETLAAGLRERG 364 Query 452 WEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACI 511 WEI+DVTAYRTVRAAPPPA TREMIKTGGFDAVCFTS+STVRNLVGIAGKPHART++ACI Sbjct 365 WEIDDVTAYRTVRAAPPPAETREMIKTGGFDAVCFTSASTVRNLVGIAGKPHARTLVACI 424 Query 512 GPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR 565 GP TAETA EFGLRVDVQP+ I LVDALAEHAARLRAEGALPPP+K R R Sbjct 425 GPSTAETAKEFGLRVDVQPEVPQIPVLVDALAEHAARLRAEGALPPPKKAKRAR 478 >gi|331699359|ref|YP_004335598.1| uroporphyrinogen-III C-methyltransferase., uroporphyrinogen-III synthase [Pseudonocardia dioxanivorans CB1190] gi|326954048|gb|AEA27745.1| Uroporphyrinogen-III C-methyltransferase., Uroporphyrinogen-III synthase [Pseudonocardia dioxanivorans CB1190] Length=513 Score = 649 bits (1675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/564 (63%), Positives = 414/564 (74%), Gaps = 61/564 (10%) Query 7 PRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPA 66 P PGRI FVGSGPGDPGLLT RA A LA A LV DPDV E + AL Sbjct 6 PTPGRIAFVGSGPGDPGLLTVRARAALAAAPLVVMDPDVAEEITAL-------------- 51 Query 67 EPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLV 126 V+ G ++RPA+G PADVA L AEA +G V RLV Sbjct 52 -------------------------VAEGAELRPAVGQPADVAAELVAEATAGRAVTRLV 86 Query 127 AGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENT 186 +GDPLT DAVI+E AVA+ + ++VPG+ A +AVP YAG+PLGS H ADVR Sbjct 87 SGDPLTTDAVIAEAQAVAKAGVPFDVVPGVPAGTAVPAYAGVPLGSGHVEADVR---AGV 143 Query 187 DWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGL 246 DW +A+ PG L+L ATA+HL E A +L D +A TP +TA GT Q++V++TL GL Sbjct 144 DWARIASVPGTLVLHATAAHLGEVAVALTDQGVAAETPVAITAGGTRNTQKTVDSTLAGL 203 Query 247 TDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQ 306 +A+G D + GPL++++G+ V RA+L+WWESRALYGW VLVPRTKDQ Sbjct 204 -------------AADGADLE-GPLVLSVGRDVAQRAELSWWESRALYGWRVLVPRTKDQ 249 Query 307 AGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWE 366 AG MS+RL +GA+P EVPTIAVEPPRSP QMERAVKGLVDGR+QW+VFTSTNAVRAVWE Sbjct 250 AGAMSDRLRVHGAIPEEVPTIAVEPPRSPTQMERAVKGLVDGRYQWVVFTSTNAVRAVWE 309 Query 367 KFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVP----SGEQSSLGLLDDFPPYD 422 KF EFGLDARAFSGVKIACVG +TA++VRAFGI PE+VP + + +S GLL+ FPPYD Sbjct 310 KFAEFGLDARAFSGVKIACVGAATAEKVRAFGIVPEIVPDIDEAQQSTSEGLLEIFPPYD 369 Query 423 SVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFD 482 + DPV+RVLLPRADIATETLA GLR+RGWEI+DVTAYRTVRAAPPPA RE IKTGGFD Sbjct 370 DILDPVDRVLLPRADIATETLAAGLRDRGWEIDDVTAYRTVRAAPPPAPIREAIKTGGFD 429 Query 483 AVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDAL 542 AVCFTSSSTVRNLVGIAGKPHARTI+ACIGP TAETA EFGLRVDVQP+ A + LVDAL Sbjct 430 AVCFTSSSTVRNLVGIAGKPHARTIVACIGPATAETAREFGLRVDVQPEEARVPTLVDAL 489 Query 543 AEHAARLRAEGALPPPRK-KSRRR 565 A HAA+LRAEGALPPP+K K+RRR Sbjct 490 AAHAAKLRAEGALPPPKKAKARRR 513 >gi|325001830|ref|ZP_08122942.1| uroporphyrin-III C-methyltransferase HemD [Pseudonocardia sp. P1] Length=500 Score = 620 bits (1600), Expect = 2e-175, Method: Compositional matrix adjust. Identities = 333/556 (60%), Positives = 398/556 (72%), Gaps = 61/556 (10%) Query 15 VGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPVSGPAPAEPVAGNGD 74 +GSGPGDP LLT RA VLA + LV TDPDVPE ++AL Sbjct 1 MGSGPGDPALLTVRARDVLAGSPLVITDPDVPESILAL---------------------- 38 Query 75 AAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVD 134 + G ++RPA+G PAD+A L EA G V RLV+GDPLT D Sbjct 39 -----------------AADGAEVRPAVGQPADIASDLLGEAGQGRSVARLVSGDPLTND 81 Query 135 AVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTDWDALAAA 194 AV++E AV+ + ++VPG+ AS+AVP YAG+ LGS+H ADVR DW ALAA+ Sbjct 82 AVVAEAMAVSASGTAFDVVPGVPASTAVPAYAGVALGSAHVEADVR---AGVDWAALAAS 138 Query 195 PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVETTLQGLTDPAVLGA 254 PGP++L AT + L + A L + TP VT+ GTT QR+V +++ L Sbjct 139 PGPVVLHATGALLGDVAAGLSAQGVPGETPVAVTSGGTTSTQRTVSSSVGKL-------- 190 Query 255 TDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLVPRTKDQAGEMSERL 314 +++G D + GPL++ +G R +L+WWESRALYGW VLVPRTKDQAG MSERL Sbjct 191 -----ASDGGDLE-GPLVLAVGDAAGRRGELSWWESRALYGWRVLVPRTKDQAGVMSERL 244 Query 315 TSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLD 374 +GA+P EVPTIAVEPPRSPAQMER+VKGLVDGR+QW+VFTSTNAV+AVWEKF EFGLD Sbjct 245 RMHGAIPEEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVKAVWEKFHEFGLD 304 Query 375 ARAFSGVKIACVGESTADRVRAFGISPELVPSGEQ----SSLGLLDDFPPYDSVFDPVNR 430 ARAFSGVKIACVG STA++VR FGI PELVP ++ +S GLLD FPP+D V DPV+R Sbjct 305 ARAFSGVKIACVGRSTAEKVREFGIEPELVPDIDEAQSSTSEGLLDIFPPHDDVLDPVDR 364 Query 431 VLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGFDAVCFTSSS 490 VLLPRADIATETL+ GL+ERGWE++DVTAYRTVRAAPPPA RE IKTGGFDAVCFTSSS Sbjct 365 VLLPRADIATETLSAGLQERGWEVDDVTAYRTVRAAPPPAPIREAIKTGGFDAVCFTSSS 424 Query 491 TVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVDALAEHAARLR 550 TVRNLVGIAGKPHART++ACIGP TAETA EFGLRVDVQP+ + + LVDALA H A+LR Sbjct 425 TVRNLVGIAGKPHARTLVACIGPATAETAREFGLRVDVQPEESRVPTLVDALASHTAKLR 484 Query 551 AEGALPPPRK-KSRRR 565 AEG LPPP+K K+RRR Sbjct 485 AEGNLPPPKKVKARRR 500 >gi|258651163|ref|YP_003200319.1| uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Nakamurella multipartita DSM 44233] gi|258554388|gb|ACV77330.1| Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase [Nakamurella multipartita DSM 44233] Length=506 Score = 604 bits (1557), Expect = 2e-170, Method: Compositional matrix adjust. Identities = 333/555 (60%), Positives = 399/555 (72%), Gaps = 59/555 (10%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RKP GRI FVG+GPGDPGLLT RAA L A+LV TDPDVP + AL Sbjct 1 MTRARKP-VGRIAFVGAGPGDPGLLTMRAAHALDAASLVVTDPDVPADITAL-------- 51 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 +G +++PA+G+PA+VAK L A A++G Sbjct 52 --------------------------------AGEAEVKPAVGEPAEVAKALVAAAKNGQ 79 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 VVRLVAGD LT D V+ E+ +V+R+ + +++PGL+A+ AV +Y+G+ +GS HTVADVR Sbjct 80 FVVRLVAGDVLTADPVVKELQSVSRSAVLFDVIPGLSAT-AVASYSGIAVGSVHTVADVR 138 Query 181 IDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRSVE 240 +DW LAAAPG L+LQA++ HLA++A L +A TP VT+ T QR+V+ Sbjct 139 ---STSDWPRLAAAPGTLLLQASSGHLADTAALLAQSGMAGETPASVTSGATLPTQRTVD 195 Query 241 TTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTVLV 300 TL L G D GPL+VT+G +T R +L+WWESRALYGW VL+ Sbjct 196 GTLATL-------------DGIGGD-MTGPLVVTVGAGITQRNRLSWWESRALYGWRVLI 241 Query 301 PRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTSTNA 360 P+TKD A EM E L +GA+P VPT+AVEPPR+PAQMERAVKGLVDGR+QWIVFTS N+ Sbjct 242 PQTKDPAEEMLELLRLHGAIPQRVPTVAVEPPRTPAQMERAVKGLVDGRYQWIVFTSINS 301 Query 361 VRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPP 420 VRAVWEKF EFGLDARAFSGV+IACV +T D VRA GI PEL+ + +QSS GLL FP Sbjct 302 VRAVWEKFVEFGLDARAFSGVRIACVDSATGDAVRALGIVPELISADQQSSAGLLSTFPE 361 Query 421 YDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGG 480 YD + DPV+RVLLPRADIATETLAEGLRERGWEI+DVTAYRTVRAAPP A RE IKTGG Sbjct 362 YDDILDPVDRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAPIREAIKTGG 421 Query 481 FDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPLVD 540 FDAVCFTSSSTVRNLVGIAGKPHAR+++AC+GPKTAETA EFGLRVDVQP+ A +G LV+ Sbjct 422 FDAVCFTSSSTVRNLVGIAGKPHARSLVACLGPKTAETAREFGLRVDVQPEVAELGALVE 481 Query 541 ALAEHAARLRAEGAL 555 ALAEHA+RLRAEGAL Sbjct 482 ALAEHASRLRAEGAL 496 >gi|284992945|ref|YP_003411499.1| Uroporphyrinogen III synthase HEM4 [Geodermatophilus obscurus DSM 43160] gi|284066190|gb|ADB77128.1| Uroporphyrinogen III synthase HEM4 [Geodermatophilus obscurus DSM 43160] Length=516 Score = 561 bits (1447), Expect = 7e-158, Method: Compositional matrix adjust. Identities = 325/559 (59%), Positives = 386/559 (70%), Gaps = 53/559 (9%) Query 1 MTRGRKPR---PGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDL 57 MTR RK G +VFVG+GPGDPG+LT RA A LA A V D VP + + D Sbjct 1 MTRFRKQNGGATGTVVFVGAGPGDPGMLTARATAALAEAHTVLVDTAVPPAIAEAVRADR 60 Query 58 PPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEAR 117 P + ++ PA G+PA+VAK A A+ Sbjct 61 PEL------------------------------------ELTPATGEPAEVAKAAVAAAK 84 Query 118 SGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVA 177 +G VVRLVAGDP T DAV+ EV AV RT + ++VPG+A+ +AVP +AG+ LG + A Sbjct 85 AGGTVVRLVAGDPFTSDAVVKEVLAVGRTSVGFDVVPGVASQTAVPAFAGVALGGTSLTA 144 Query 178 DVRIDPENTDWDALAAA--PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQ 235 D+R + A A PL+LQ A L ++A L++ L+ ST VVT G+ Sbjct 145 DLRGGEADLAALAAATKRLDAPLVLQGNAEDLPDAAARLVEGGLSGSTAVVVTTGGSGTG 204 Query 236 QRSVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYG 295 QRSV L + + G D+ +GP++ T+G V RA+L+WWESR L+G Sbjct 205 QRSVVAKLAAVAE-----------KTAGLDAVSGPVVATVGSAVDKRARLSWWESRPLFG 253 Query 296 WTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVF 355 W VLVPRTKDQAGEMS+RL +YGA+PVEVPTIAVEPPRSPAQM+RA+KGLV GR+ WIVF Sbjct 254 WRVLVPRTKDQAGEMSDRLRAYGAVPVEVPTIAVEPPRSPAQMDRAIKGLVTGRYGWIVF 313 Query 356 TSTNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLL 415 TS NAV+AV EKF E GLDARAF+GVK+ACVGESTAD VRAFGI PELVP+G+QSS GLL Sbjct 314 TSVNAVKAVREKFVELGLDARAFAGVKVACVGESTADAVRAFGIVPELVPTGQQSSEGLL 373 Query 416 DDFPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREM 475 DFP YD V DP++RVLLPRADIATETLA GL+ERGWEI+DVTAYRTVRAAPPPA RE Sbjct 374 ADFPEYDDVLDPIDRVLLPRADIATETLAAGLKERGWEIDDVTAYRTVRAAPPPAPVREA 433 Query 476 IKTGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAI 535 IK GGFDAVCFTSSSTVRNLVGIAGKPHA+T++A IGP+TA TA EFGLRVDVQP TAA+ Sbjct 434 IKGGGFDAVCFTSSSTVRNLVGIAGKPHAKTVVAVIGPQTAATAQEFGLRVDVQPGTAAV 493 Query 536 GPLVDALAEHAARLR-AEG 553 GPLVDALAEHA LR AEG Sbjct 494 GPLVDALAEHALSLREAEG 512 >gi|302870085|ref|YP_003838722.1| Uroporphyrinogen III synthase HEM4 [Micromonospora aurantiaca ATCC 27029] gi|302572944|gb|ADL49146.1| Uroporphyrinogen III synthase HEM4 [Micromonospora aurantiaca ATCC 27029] Length=526 Score = 558 bits (1437), Expect = 1e-156, Method: Compositional matrix adjust. Identities = 314/563 (56%), Positives = 371/563 (66%), Gaps = 53/563 (9%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RKP G+I FVG+GPGDPGLLT RA L A V D VPE ++A + P Sbjct 1 MTRTRKP-VGQIAFVGAGPGDPGLLTRRALDALVEADQVVYDRGVPESLLAHVRAQARP- 58 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 G + PA G P DVAK L + ARSG Sbjct 59 ----------------------------------GAEFSPAEGVPGDVAKVLISAARSGQ 84 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 + V LVAGDP D+V+ EV AVART H E+VPG+ + V TYAG+PL T ADV Sbjct 85 NAVHLVAGDPFGHDSVVKEVQAVARTAAHFEVVPGVGQAEGVATYAGVPLPGVRTAADVE 144 Query 181 IDPENTDWDALAAA--PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 D D++ALA A G L L A LA L+ + +T VT GT Q + Sbjct 145 -DVTALDFEALATAVGRGSLALAVDAGDLAAVRDGLLAAGVDGTTAVGVTGDGTGETQYT 203 Query 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 +T+ A LG T G +++T+G VT R KL+WWE+R LYGW V Sbjct 204 TTSTVDSFV-AAALGFT-------------GRVVLTVGAAVTDRDKLSWWENRPLYGWKV 249 Query 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 LVPRTK+QAG MS RL +YGA+P EVPTIAVEPPR+PAQMERAVKGLVDGR+ W++FTS Sbjct 250 LVPRTKEQAGVMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVDGRYAWVIFTSV 309 Query 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 NAVRAVWEKF E GLDAR F GVKIAC+G++TA+ VRAFGI PEL+PSGEQSS GLL +F Sbjct 310 NAVRAVWEKFAEHGLDARHFGGVKIACIGDATAEAVRAFGIQPELIPSGEQSSEGLLAEF 369 Query 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 P+D + DPV RVLLPRADIATETLA GL ERGWE++DVTAYRTVRAAPPPA R+ IK+ Sbjct 370 SPHDEILDPVGRVLLPRADIATETLAAGLTERGWEVDDVTAYRTVRAAPPPAEIRDAIKS 429 Query 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 GGFDAV FTSSSTVRNLVGIAGKPHART++A IGPKTAETA EFGLRVDVQP A++ L Sbjct 430 GGFDAVLFTSSSTVRNLVGIAGKPHARTVVAVIGPKTAETATEFGLRVDVQPPHASVPDL 489 Query 539 VDALAEHAARLRAEGALPPPRKK 561 V+ALA +A LR + A P +++ Sbjct 490 VEALAAYAVELREKLAAMPAKQR 512 >gi|330470293|ref|YP_004408036.1| uroporphyrinogen iii synthase hem4 [Verrucosispora maris AB-18-032] gi|328813264|gb|AEB47436.1| uroporphyrinogen iii synthase hem4 [Verrucosispora maris AB-18-032] Length=526 Score = 558 bits (1437), Expect = 1e-156, Method: Compositional matrix adjust. Identities = 317/563 (57%), Positives = 374/563 (67%), Gaps = 53/563 (9%) Query 1 MTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDLPPV 60 MTR RKP GRI FVG+GPGDPGLLT RA L +A V D VPE + L V Sbjct 1 MTRTRKP-VGRIAFVGAGPGDPGLLTRRAHDALVDADQVVYDRGVPESL-------LDVV 52 Query 61 SGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEARSGV 120 A AE + PA G P DVAK L + AR+G Sbjct 53 RAEAKAET----------------------------EFTPAEGVPGDVAKVLISAARAGQ 84 Query 121 DVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVR 180 + V LVAGDP D+V+ EV AVART H E+VPG++ + V TYAG+PL T ADV Sbjct 85 NAVHLVAGDPFGHDSVVKEVQAVARTAAHFEVVPGVSQAEGVATYAGVPLPGVRTTADVE 144 Query 181 IDPENTDWDALAAA--PGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQRS 238 D D+DALAAA G L L A LA L+ + T VT GT Q + Sbjct 145 -DVSTLDFDALAAAVQRGSLALAVDAGDLAAIRDGLLAAGVDGGTAVGVTGDGTGETQYT 203 Query 239 VETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWTV 298 +++ A LG T G +++T+G+ V+ R KL+WWE+R LYGW V Sbjct 204 TTSSVDSFV-AAALGFT-------------GRVVLTVGEGVSQRDKLSWWENRPLYGWKV 249 Query 299 LVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTST 358 LVPRTK+QAG MS RL +YGA+P EVPTIAVEPPR+PAQMERAVKGLVDGR+ W++FTS Sbjct 250 LVPRTKEQAGVMSARLRAYGAIPCEVPTIAVEPPRTPAQMERAVKGLVDGRYAWVIFTSV 309 Query 359 NAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDF 418 NAVRAVWEKF E GLDAR F GVKIAC+GE+TA+ VRAFGI PEL+P+GEQSS GLL +F Sbjct 310 NAVRAVWEKFAEHGLDARHFGGVKIACIGEATAEAVRAFGIQPELIPTGEQSSEGLLAEF 369 Query 419 PPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKT 478 P+D V DPV RVLLPRADIATETLA GL ERGWE++DVTAYRTVRAAPPPA R+ IK+ Sbjct 370 SPHDEVLDPVGRVLLPRADIATETLAAGLTERGWEVDDVTAYRTVRAAPPPAEIRDAIKS 429 Query 479 GGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGPL 538 GGFDAV FTSSSTVRNLVGIAGKPHART++A IGPKTAETA EFGLRVDVQP A++ L Sbjct 430 GGFDAVLFTSSSTVRNLVGIAGKPHARTVVAVIGPKTAETATEFGLRVDVQPPHASVPDL 489 Query 539 VDALAEHAARLRAEGALPPPRKK 561 V+ALA +A LR + A P +++ Sbjct 490 VEALAGYAVELREKLAAMPAKQR 512 Lambda K H 0.316 0.132 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1264862876760 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40