BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0555 Length=554 Score E Sequences producing significant alignments: (Bits) Value gi|15607695|ref|NP_215069.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-... 1093 0.0 gi|15839953|ref|NP_334990.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-... 1092 0.0 gi|306779410|ref|ZP_07417747.1| bifunctional menaquinone biosynt... 1092 0.0 gi|340625582|ref|YP_004744034.1| putative bifunctional menaquino... 1089 0.0 gi|289568483|ref|ZP_06448710.1| 2-oxoglutarate decarboxylase [My... 954 0.0 gi|336460471|gb|EGO39366.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3... 950 0.0 gi|183980922|ref|YP_001849213.1| bifunctional 2-succinyl-6-hydro... 940 0.0 gi|118616457|ref|YP_904789.1| 2-succinyl-5-enolpyruvyl-6-hydroxy... 934 0.0 gi|41410150|ref|NP_962986.1| 2-succinyl-6-hydroxy-2,4-cyclohexad... 932 0.0 gi|240169235|ref|ZP_04747894.1| 2-succinyl-6-hydroxy-2,4-cyclohe... 914 0.0 gi|342858935|ref|ZP_08715589.1| 2-succinyl-5-enolpyruvyl-6-hydro... 909 0.0 gi|296168319|ref|ZP_06850243.1| 2-succinyl-5-enolpyruvyl-6-hydro... 907 0.0 gi|15828215|ref|NP_302478.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-... 906 0.0 gi|254818364|ref|ZP_05223365.1| 2-succinyl-5-enolpyruvyl-6-hydro... 901 0.0 gi|333989189|ref|YP_004521803.1| bifunctional 2-succinyl-6-hydro... 893 0.0 gi|120401990|ref|YP_951819.1| 2-succinyl-5-enolpyruvyl-6-hydroxy... 880 0.0 gi|118471524|ref|YP_885503.1| 2-succinyl-5-enolpyruvyl-6-hydroxy... 880 0.0 gi|193806140|sp|A1T3R3.2|MEND_MYCVP RecName: Full=2-succinyl-5-e... 879 0.0 gi|193806133|sp|A0QRG5.2|MEND_MYCS2 RecName: Full=2-succinyl-5-e... 878 0.0 gi|126433356|ref|YP_001069047.1| 2-succinyl-5-enolpyruvyl-6-hydr... 865 0.0 gi|108797730|ref|YP_637927.1| 2-succinyl-5-enolpyruvyl-6-hydroxy... 864 0.0 gi|145225837|ref|YP_001136515.1| 2-succinyl-5-enolpyruvyl-6-hydr... 843 0.0 gi|169631012|ref|YP_001704661.1| 2-succinyl-5-enolpyruvyl-6-hydr... 843 0.0 gi|193806146|sp|A4T174.2|MEND_MYCGI RecName: Full=2-succinyl-5-e... 842 0.0 gi|226305193|ref|YP_002765151.1| menaquinone biosynthesis protei... 720 0.0 gi|229490730|ref|ZP_04384568.1| 2-succinyl-6-hydroxy-2, 4-cycloh... 719 0.0 gi|325675334|ref|ZP_08155018.1| 2-succinyl-5-enolpyruvyl-6-hydro... 712 0.0 gi|312141029|ref|YP_004008365.1| 2-succinyl-6-hydroxy-2, 4-cyclo... 712 0.0 gi|111018990|ref|YP_701962.1| 2-succinyl-5-enolpyruvyl-6-hydroxy... 704 0.0 gi|226361085|ref|YP_002778863.1| 2-succinyl-5-enolpyruvyl-6-hydr... 703 0.0 gi|333918063|ref|YP_004491644.1| 2-succinyl-5-enolpyruvyl-6-hydr... 684 0.0 gi|343925610|ref|ZP_08765127.1| 2-succinyl-5-enolpyruvyl-6-hydro... 673 0.0 gi|54027107|ref|YP_121349.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-... 671 0.0 gi|296138462|ref|YP_003645705.1| thiamine pyrophosphate TPP bind... 664 0.0 gi|296393035|ref|YP_003657919.1| 2-succinyl-5-enolpyruvyl-6-hydr... 646 0.0 gi|262201085|ref|YP_003272293.1| 2-succinyl-5-enolpyruvyl-6-hydr... 645 0.0 gi|326383006|ref|ZP_08204695.1| 2-succinyl-5-enolpyruvyl-6-hydro... 642 0.0 gi|298524043|ref|ZP_07011452.1| conserved hypothetical protein [... 553 2e-155 gi|254777021|ref|ZP_05218537.1| 2-succinyl-5-enolpyruvyl-6-hydro... 495 8e-138 gi|317506081|ref|ZP_07963908.1| menD protein [Segniliparus rugos... 411 1e-112 gi|331699329|ref|YP_004335568.1| 2-succinyl-5-enolpyruvyl-6-hydr... 400 3e-109 gi|256380685|ref|YP_003104345.1| 2-succinyl-6-hydroxy-2,4-cycloh... 400 4e-109 gi|257054387|ref|YP_003132219.1| 2-succinyl-6-hydroxy-2,4-cycloh... 395 9e-108 gi|213964900|ref|ZP_03393099.1| menaquinone biosynthesis protein... 394 2e-107 gi|302523865|ref|ZP_07276207.1| 2-succinyl-6-hydroxy-2,4-cyclohe... 390 3e-106 gi|134103340|ref|YP_001109001.1| 2-succinyl-6-hydroxy-2,4-cycloh... 389 8e-106 gi|300782441|ref|YP_003762732.1| 2-succinyl-5-enolpyruvyl-6-hydr... 380 3e-103 gi|340523810|gb|AEK39015.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3... 380 3e-103 gi|336326472|ref|YP_004606438.1| 2-oxoglutarate decarboxylase / ... 379 8e-103 gi|340795377|ref|YP_004760840.1| 2-oxoglutarate decarboxylase / ... 369 6e-100 >gi|15607695|ref|NP_215069.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium tuberculosis H37Rv] gi|31791737|ref|NP_854230.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium bovis AF2122/97] gi|121636473|ref|YP_976696.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium bovis BCG str. Pasteur 1173P2] 69 more sequence titles Length=554 Score = 1093 bits (2826), Expect = 0.0, Method: Compositional matrix adjust. Identities = 553/554 (99%), Positives = 554/554 (100%), Gaps = 0/554 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP Sbjct 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL Sbjct 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT Sbjct 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA Sbjct 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG Sbjct 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ Sbjct 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR Sbjct 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 541 SSLRQLHAAIKAAL 554 >gi|15839953|ref|NP_334990.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium tuberculosis CDC1551] gi|13880093|gb|AAK44804.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase [Mycobacterium tuberculosis CDC1551] gi|323721029|gb|EGB30093.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis CDC1551A] Length=554 Score = 1092 bits (2825), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/554 (99%), Positives = 554/554 (100%), Gaps = 0/554 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVV+DELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVIDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP Sbjct 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL Sbjct 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT Sbjct 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA Sbjct 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG Sbjct 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ Sbjct 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR Sbjct 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 541 SSLRQLHAAIKAAL 554 >gi|306779410|ref|ZP_07417747.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis SUMu002] gi|306787566|ref|ZP_07425888.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis SUMu004] gi|306792116|ref|ZP_07430418.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis SUMu005] gi|308327624|gb|EFP16475.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis SUMu002] gi|308335766|gb|EFP24617.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis SUMu004] gi|308339372|gb|EFP28223.1| bifunctional menaquinone biosynthesis protein menD [Mycobacterium tuberculosis SUMu005] Length=554 Score = 1092 bits (2824), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/554 (99%), Positives = 554/554 (100%), Gaps = 0/554 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP Sbjct 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDI+LSVDTVVISGHGAGVHPNL Sbjct 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDINLSVDTVVISGHGAGVHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT Sbjct 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA Sbjct 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG Sbjct 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ Sbjct 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR Sbjct 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 541 SSLRQLHAAIKAAL 554 >gi|340625582|ref|YP_004744034.1| putative bifunctional menaquinone biosynthesis protein MEND : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase)/2-oxoglutarate decarboxylase (alpha-ketoglutarate decarboxylase) (KDC) [Mycobacterium canettii CIPT 140010059] gi|340003772|emb|CCC42898.1| putative bifunctional menaquinone biosynthesis protein MEND : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha-ketoglutarate decarboxylase) (KDC) [Mycobacterium canettii CIPT 140010059] Length=554 Score = 1089 bits (2817), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/554 (99%), Positives = 553/554 (99%), Gaps = 0/554 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP Sbjct 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL Sbjct 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT Sbjct 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA Sbjct 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG Sbjct 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ Sbjct 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDEL PTLDQPGAGMRVLEVKADR Sbjct 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELRPTLDQPGAGMRVLEVKADR 540 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 541 SSLRQLHAAIKAAL 554 >gi|289568483|ref|ZP_06448710.1| 2-oxoglutarate decarboxylase [Mycobacterium tuberculosis T17] gi|289542237|gb|EFD45885.1| 2-oxoglutarate decarboxylase [Mycobacterium tuberculosis T17] Length=482 Score = 954 bits (2467), Expect = 0.0, Method: Compositional matrix adjust. Identities = 481/482 (99%), Positives = 482/482 (100%), Gaps = 0/482 (0%) Query 73 VCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRA 132 +CVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRA Sbjct 1 MCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRA 60 Query 133 SISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPL 192 SISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPL Sbjct 61 SISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPL 120 Query 193 GAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAP 252 GAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAP Sbjct 121 GAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAP 180 Query 253 RSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQ 312 RSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQ Sbjct 181 RSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQ 240 Query 313 ATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQL 372 ATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQL Sbjct 241 ATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQL 300 Query 373 VLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPP 432 VLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPP Sbjct 301 VLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPP 360 Query 433 RTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI 492 RTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI Sbjct 361 RTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI 420 Query 493 FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKA 552 FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKA Sbjct 421 FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKA 480 Query 553 AL 554 AL Sbjct 481 AL 482 >gi|336460471|gb|EGO39366.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase [Mycobacterium avium subsp. paratuberculosis S397] Length=545 Score = 950 bits (2456), Expect = 0.0, Method: Compositional matrix adjust. Identities = 488/554 (89%), Positives = 507/554 (92%), Gaps = 9/554 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALADADRAGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGL I AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLVIAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER ALNATWRSATCRVLAAATG+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRAAISLGLAEDAPERLDALNATWRSATCRVLAAATGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP GA TP GRP G+PWTYTPPV+FDQPLDIDLS DTVVI+GHGAG HPNL Sbjct 181 LREPLVPDPEPHGAPTPAGRPGGRPWTYTPPVSFDQPLDIDLSPDTVVIAGHGAGTHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP + DNPLHPLAL LLRP+QVIMLGRPTLHRPVS LLAD +VPV+ALTT Sbjct 241 AQLPTVAEPTAP-APDNPLHPLALRLLRPKQVIMLGRPTLHRPVSALLADPQVPVYALTT 299 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAP PAWL RC NRHA+AAVR QLAAHPLTTGLHVAA Sbjct 300 GPRWPDVSGNSQATGTRAVTTGAPSPAWLHRCEQANRHAVAAVRGQLAAHPLTTGLHVAA 359 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV+ ALRPGDQLVLGASNPVRD AL GLD+ IRVRSNRGVAGIDGTVSTAIGAALA+E Sbjct 360 AVADALRPGDQLVLGASNPVRDAALVGLDSHHIRVRSNRGVAGIDGTVSTAIGAALAHEA 419 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AH+ RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELLEQ Sbjct 420 AHDG--------RTVALIGDLTFVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELLEQ 471 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSR+FGTPHDVDVGALCRAYHVES QIEV EL LD+PG GMRVLEVKADR Sbjct 472 GDPRFSDVSSRVFGTPHDVDVGALCRAYHVESAQIEVGELAAALDEPGPGMRVLEVKADR 531 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 532 SSLRQLHAAIKAAL 545 >gi|183980922|ref|YP_001849213.1| bifunctional 2-succinyl-6-hydroxy-2,4- cyclohexadiene-1-carboxylate synthase, MenD [Mycobacterium marinum M] gi|254810349|sp|B2HRP6.1|MEND_MYCMM RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|183174248|gb|ACC39358.1| bifunctional 2-succinyl-6-hydroxy-2,4- cyclohexadiene-1-carboxylate synthase, MenD [Mycobacterium marinum M] Length=548 Score = 940 bits (2430), Expect = 0.0, Method: Compositional matrix adjust. Identities = 491/556 (89%), Positives = 514/556 (93%), Gaps = 10/556 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAG+ Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+GAGAP CVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAVGAGAPACVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDA ER +LNA+WRSATCRVLAAA G+RTANAGPVHFDIP Sbjct 121 EQLGYFGTQVRATISLGLAEDAHERLDSLNASWRSATCRVLAAAMGSRTANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP GAVTPPGRP G+PWTYTPPVTFDQPL+IDLS DTVVI+GHGAGVHPNL Sbjct 181 LREPLVPDPEPHGAVTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNL 240 Query 241 AALPTVAEPTAPR--SGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFAL 298 LPT+AEPTAP SG NPLHPLALPLLRP+QVIMLGRPTLHRPVS LLAD EVPVFAL Sbjct 241 VQLPTIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPEVPVFAL 300 Query 299 TTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHV 358 TTGPRWPDVSGNSQATGTRA+ TG P P+WLDRCA MNRHA+AAVREQLAAHPLTTGLHV Sbjct 301 TTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAAVREQLAAHPLTTGLHV 360 Query 359 AAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAY 418 AAAV+ ALRPGDQLVLGASNPVRD AL GLDT G+RVRSNRGVAGIDGTVSTAIGAAL Y Sbjct 361 AAAVAGALRPGDQLVLGASNPVRDAALVGLDTAGLRVRSNRGVAGIDGTVSTAIGAALGY 420 Query 419 EGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELL 478 E H RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELL Sbjct 421 ERDHHG--------RTVALIGDLTFVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELL 472 Query 479 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKA 538 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVE+RQIEVD+L LD+PG+G+RVLEVKA Sbjct 473 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKA 532 Query 539 DRSSLRQLHAAIKAAL 554 DRSSLRQLHAAIKAAL Sbjct 533 DRSSLRQLHAAIKAAL 548 >gi|118616457|ref|YP_904789.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium ulcerans Agy99] gi|193806095|sp|A0PLU9.1|MEND_MYCUA RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|118568567|gb|ABL03318.1| bifunctional 2-succinyl-6-hydroxy-2,4- cyclohexadiene-1-carboxylate synthase, MenD [Mycobacterium ulcerans Agy99] Length=548 Score = 934 bits (2415), Expect = 0.0, Method: Compositional matrix adjust. Identities = 488/556 (88%), Positives = 513/556 (93%), Gaps = 10/556 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAG+ Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+GAGAP CVAMTSGTAVANLGPAVVE NYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAVGAGAPACVAMTSGTAVANLGPAVVETNYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDA ER +LNA+WRSATCR+LAAA G+RTANAGPVHFDIP Sbjct 121 EQLGYFGTQVRATISLGLAEDAHERLDSLNASWRSATCRMLAAAMGSRTANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDP+P GAVTPPGRP G+PWTYTPPVTFDQPL+IDLS DTVVI+GHGAGVHPNL Sbjct 181 LREPLVPDPDPHGAVTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNL 240 Query 241 AALPTVAEPTAPR--SGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFAL 298 LPT+AEPTAP SG NPLHPLALPLLRP+QVIMLGRPTLHRPVS LLAD EVPVFAL Sbjct 241 VQLPTIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPEVPVFAL 300 Query 299 TTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHV 358 TTGPRWPDVSGNSQATGTRA+ TG P P+WLDRCA MNRHA+AAVREQLAAHPLTTGLHV Sbjct 301 TTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAAVREQLAAHPLTTGLHV 360 Query 359 AAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAY 418 AAAV+ ALRPGDQLVLGASNPVRD AL GLDT G+RVRSNRGVAGIDGTVSTAIGAAL Y Sbjct 361 AAAVAGALRPGDQLVLGASNPVRDAALVGLDTAGLRVRSNRGVAGIDGTVSTAIGAALGY 420 Query 419 EGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELL 478 E H RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELL Sbjct 421 ERDHHG--------RTVALIGDLTFVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELL 472 Query 479 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKA 538 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVE+RQIEVD+L LD+PG+G+RVLEVKA Sbjct 473 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKA 532 Query 539 DRSSLRQLHAAIKAAL 554 DRSSLRQLHAAIKAAL Sbjct 533 DRSSLRQLHAAIKAAL 548 >gi|41410150|ref|NP_962986.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase [Mycobacterium avium subsp. paratuberculosis K-10] gi|118464066|ref|YP_883717.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium avium 104] gi|81413024|sp|Q73SM1.1|MEND_MYCPA RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|193806085|sp|A0QLC9.1|MEND_MYCA1 RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|41398983|gb|AAS06602.1| MenD [Mycobacterium avium subsp. paratuberculosis K-10] gi|118165353|gb|ABK66250.1| 2-oxoglutarate decarboxylase [Mycobacterium avium 104] Length=545 Score = 932 bits (2408), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/554 (89%), Positives = 508/554 (92%), Gaps = 9/554 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALADADRAGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAI AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER ALNATWRSATCRVLAAATG+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRAAISLGLAEDAPERLDALNATWRSATCRVLAAATGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP GA TP GRP G+PWTYTPPV+FDQPLDIDLS DTVVI+GHGAG HPNL Sbjct 181 LREPLVPDPEPHGAPTPAGRPGGRPWTYTPPVSFDQPLDIDLSPDTVVIAGHGAGTHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP + DNPLHPLAL LLRP+QVIMLGRPTLHRPVS LLAD +VPV+ALTT Sbjct 241 AQLPTVAEPTAP-APDNPLHPLALRLLRPKQVIMLGRPTLHRPVSALLADPQVPVYALTT 299 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAP PAWL RC NRHA+AAVR QLAAHPLTTGLHVAA Sbjct 300 GPRWPDVSGNSQATGTRAVTTGAPSPAWLHRCEQANRHAVAAVRGQLAAHPLTTGLHVAA 359 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV+ ALRPGDQLVLGASNPVRD AL GLD+ IRVRSNRGVAGIDGTVSTAIGAALA+E Sbjct 360 AVADALRPGDQLVLGASNPVRDAALVGLDSHHIRVRSNRGVAGIDGTVSTAIGAALAHEA 419 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AH+ RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELLEQ Sbjct 420 AHDG--------RTVALIGDLTFVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELLEQ 471 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSR+FGTPHDVDVGALCRAYHVES QIEV EL LD+PG GMRVLEVKADR Sbjct 472 GDPRFSDVSSRVFGTPHDVDVGALCRAYHVESAQIEVGELAAALDEPGPGMRVLEVKADR 531 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 532 SSLRQLHAAIKAAL 545 >gi|240169235|ref|ZP_04747894.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase [Mycobacterium kansasii ATCC 12478] Length=549 Score = 914 bits (2362), Expect = 0.0, Method: Compositional matrix adjust. Identities = 482/554 (88%), Positives = 505/554 (92%), Gaps = 5/554 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADR+GR+RLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRTGRVRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYE+LGTGANQTM Sbjct 61 LAIGLAVAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYEMLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER ALNATWRSATCRVL AA G+R+ANAGPVHFDIP Sbjct 121 EQLGYFGTQVRATISLGLAEDAPERLPALNATWRSATCRVLVAAKGSRSANAGPVHFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP G V PPGRP GKPWTYTPPVTFDQPLDID+S DTVVI+GHGAG HPNL Sbjct 181 LREPLVPDPEPHGGVVPPGRPDGKPWTYTPPVTFDQPLDIDVSADTVVIAGHGAGAHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP + + LHPL LPLLRPQQVIMLGRPTLHRPVS LLA+ EVPV+ALTT Sbjct 241 AELPTVAEPTAPYAPNP-LHPLTLPLLRPQQVIMLGRPTLHRPVSALLANPEVPVYALTT 299 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAV TG P P WL RCA +NRHA+AAVREQLAAHPLTTGLHVAA Sbjct 300 GPRWPDVSGNSQATGTRAVVTGTPNPKWLRRCADLNRHALAAVREQLAAHPLTTGLHVAA 359 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV+ LR GDQLVLGASNPVRD AL GL TRGI+VRSNRGVAGIDGTVSTAIGAALAYE Sbjct 360 AVAATLRAGDQLVLGASNPVRDAALVGLSTRGIQVRSNRGVAGIDGTVSTAIGAALAYER 419 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AHE RTIALIGDLTFVHDSSGLLIGPTEP P+ LTIVVSNDNGGGIFELLEQ Sbjct 420 AHETAHQ----GRTIALIGDLTFVHDSSGLLIGPTEPAPQRLTIVVSNDNGGGIFELLEQ 475 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEV +L LD+P G+RVLEVKADR Sbjct 476 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVQQLQAALDEPNPGLRVLEVKADR 535 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAI+AAL Sbjct 536 SSLRQLHAAIRAAL 549 >gi|342858935|ref|ZP_08715589.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium colombiense CECT 3035] gi|342133176|gb|EGT86379.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium colombiense CECT 3035] Length=552 Score = 909 bits (2349), Expect = 0.0, Method: Compositional matrix adjust. Identities = 494/554 (90%), Positives = 515/554 (93%), Gaps = 2/554 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAI AGAPVCVAMTSGTAVANLGPAV+EANYARVPL+VLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIAAGAPVCVAMTSGTAVANLGPAVIEANYARVPLVVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAP+R ALNATWRSATCRVL AATG+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRATISLGLAEDAPDRLDALNATWRSATCRVLVAATGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDP+P A TPPGRP G+PWTYTPPV+FDQPLD+DLS DTVVI+GHGAGV PNL Sbjct 181 LREPLVPDPDPQ-APTPPGRPGGRPWTYTPPVSFDQPLDVDLSPDTVVIAGHGAGVQPNL 239 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP NPLHPLALPLLRP+QVIMLGRPTLHRPVS LLAD +VPVFALTT Sbjct 240 AQLPTVAEPTAPAPA-NPLHPLALPLLRPKQVIMLGRPTLHRPVSALLADPQVPVFALTT 298 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTGAP PAWL RCA +NRHA+AAVR QLAAHPLTTGLHVAA Sbjct 299 GPRWPDVSGNSQATGTRAVTTGAPSPAWLQRCAEINRHALAAVRSQLAAHPLTTGLHVAA 358 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV+ AL PGDQLVLGASNPVRD AL GLDTRGIRVRSNRGVAGIDGTVSTAIGAALA+EG Sbjct 359 AVADALAPGDQLVLGASNPVRDAALVGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAHEG 418 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 + ER G PD P RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELLEQ Sbjct 419 SRERDGGPDGPARTVALIGDLTFVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELLEQ 478 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSR+FGTPHDVDVGALCRAYHVESRQIEV EL LD+P GMRVLEVKADR Sbjct 479 GDPRFSDVSSRVFGTPHDVDVGALCRAYHVESRQIEVGELATALDEPAPGMRVLEVKADR 538 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 539 SSLRQLHAAIKAAL 552 >gi|296168319|ref|ZP_06850243.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295896750|gb|EFG76383.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=546 Score = 907 bits (2344), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/554 (89%), Positives = 507/554 (92%), Gaps = 9/554 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFAL DAD +GRIRLHVRIDERTAGY Sbjct 2 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALADADSAGRIRLHVRIDERTAGY 61 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAI AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYE+LGTGANQTM Sbjct 62 LAIGLAIAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYEMLGTGANQTM 121 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER ALNATWRSATCRVL AATG+R ANAGPV FDIP Sbjct 122 EQLGYFGTQVRAAISLGLAEDAPERLDALNATWRSATCRVLVAATGSRAANAGPVQFDIP 181 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP GA PPGRP G+PWTYTPPVTFDQPLDID++ DTVVI+GHGAG HPNL Sbjct 182 LREPLVPDPEPRGAAIPPGRPGGRPWTYTPPVTFDQPLDIDVTPDTVVIAGHGAGAHPNL 241 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP G NPLHPLALPLLRP+QVIMLGRPTLHRPVS LLAD +VPV+ALTT Sbjct 242 AELPTVAEPTAPAPG-NPLHPLALPLLRPKQVIMLGRPTLHRPVSALLADPKVPVYALTT 300 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVTTG P PAWL RCA +NRHA AVR QL AHPLTTGLHVAA Sbjct 301 GPRWPDVSGNSQATGTRAVTTGTPNPAWLTRCAEINRHANDAVRGQLEAHPLTTGLHVAA 360 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV+ ALRPGDQLVLGASNPVRD AL GLDT GIRVRSNRGVAGIDGTVSTAIGAALA+EG Sbjct 361 AVADALRPGDQLVLGASNPVRDAALVGLDTHGIRVRSNRGVAGIDGTVSTAIGAALAHEG 420 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 AH+ RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELLEQ Sbjct 421 AHDG--------RTVALIGDLTFVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELLEQ 472 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVD+L LD+P AGMRVLEVKADR Sbjct 473 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDQLSAALDEPAAGMRVLEVKADR 532 Query 541 SSLRQLHAAIKAAL 554 SSLRQLHAAIKAAL Sbjct 533 SSLRQLHAAIKAAL 546 >gi|15828215|ref|NP_302478.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium leprae TN] gi|221230692|ref|YP_002504108.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium leprae Br4923] gi|81536823|sp|Q9CBB0.1|MEND_MYCLE RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|254810348|sp|B8ZSY2.1|MEND_MYCLB RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|13093908|emb|CAC31786.1| putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase [Mycobacterium leprae] gi|219933799|emb|CAR72368.1| putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase [Mycobacterium leprae Br4923] Length=556 Score = 906 bits (2342), Expect = 0.0, Method: Compositional matrix adjust. Identities = 474/556 (86%), Positives = 497/556 (90%), Gaps = 2/556 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDAD +GRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADHAGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAVAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER +LNATWRSATCRVL AATG+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRAAISLGLAEDAPERLDSLNATWRSATCRVLVAATGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPL+PDPEP GA+TP GRP GKPWTY P VTFDQPL+IDLS DTVVI+GHGAGVHPNL Sbjct 181 LREPLIPDPEPHGAITPQGRPGGKPWTYIPQVTFDQPLEIDLSADTVVIAGHGAGVHPNL 240 Query 241 AALPTVAEPTAPRS--GDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFAL 298 LP VAEPTAP PLHPLALPLL P+QVIMLGRPTLHRPVS LLAD +VPV+AL Sbjct 241 TELPIVAEPTAPFGPYRPYPLHPLALPLLHPKQVIMLGRPTLHRPVSALLADPQVPVYAL 300 Query 299 TTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHV 358 TTGP WPDVSGNSQA GTRAVTTG P PAWL RCA MN+HAI+ VR QLAAHPL TGLHV Sbjct 301 TTGPCWPDVSGNSQAAGTRAVTTGTPHPAWLQRCAEMNQHAISTVRSQLAAHPLITGLHV 360 Query 359 AAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAY 418 AAAV+ ALRPGDQLVLGASNPVRD+AL GL T GI+VRSNRGVAGIDGTVSTAIGAALAY Sbjct 361 AAAVADALRPGDQLVLGASNPVRDMALVGLSTDGIQVRSNRGVAGIDGTVSTAIGAALAY 420 Query 419 EGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELL 478 E + GS D P RT+ALIGDL FVHDSSGLLIGPTEP P+ L IVVSNDNGGGIFELL Sbjct 421 ERSPGYAGSTDRPARTVALIGDLAFVHDSSGLLIGPTEPTPQQLKIVVSNDNGGGIFELL 480 Query 479 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKA 538 EQGDPR S VSSRIFGTPHDVDVGALCRAYHVE RQIEVD+L LD+PG GMRVLEVKA Sbjct 481 EQGDPRLSAVSSRIFGTPHDVDVGALCRAYHVEGRQIEVDKLREALDEPGVGMRVLEVKA 540 Query 539 DRSSLRQLHAAIKAAL 554 DRSSLRQLHAAI A L Sbjct 541 DRSSLRQLHAAITATL 556 >gi|254818364|ref|ZP_05223365.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium intracellulare ATCC 13950] Length=552 Score = 901 bits (2329), Expect = 0.0, Method: Compositional matrix adjust. Identities = 497/556 (90%), Positives = 511/556 (92%), Gaps = 6/556 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAI AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER A NATWRSATCRVLAAATG+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRATISLGLAEDAPERLDAHNATWRSATCRVLAAATGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP GAV PPGRP G+PWTYTPPVTFDQPL+IDL+ DTVVI+GHGAG HP L Sbjct 181 LREPLVPDPEPRGAVLPPGRPGGRPWTYTPPVTFDQPLEIDLTPDTVVIAGHGAGTHPAL 240 Query 241 AALPTVAEPT--APRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFAL 298 A LPTVAEPT + + NPLHPLALPLLRP+QVIMLGRPTLHRPVS LLAD +VPVFAL Sbjct 241 AQLPTVAEPTSFSGQPPPNPLHPLALPLLRPKQVIMLGRPTLHRPVSALLADPKVPVFAL 300 Query 299 TTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHV 358 TTGPRWPDVSGNSQATGTRAVTTGAP PAWL RCA NRHA AVR QLAAHPLTTGLHV Sbjct 301 TTGPRWPDVSGNSQATGTRAVTTGAPNPAWLHRCAETNRHANDAVRGQLAAHPLTTGLHV 360 Query 359 AAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAY 418 AAAV+ ALRPGDQLVLGASNPVRD AL GLDT GIRVRSNRGVAGIDGTVSTAIGAAL Sbjct 361 AAAVAAALRPGDQLVLGASNPVRDAALVGLDTHGIRVRSNRGVAGIDGTVSTAIGAAL-- 418 Query 419 EGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELL 478 AHER G PD+P RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELL Sbjct 419 --AHERVGDPDNPARTVALIGDLTFVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELL 476 Query 479 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKA 538 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDEL LD PG GMRVLEVKA Sbjct 477 EQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELHAALDDPGPGMRVLEVKA 536 Query 539 DRSSLRQLHAAIKAAL 554 DRSSLRQLHAAIKAAL Sbjct 537 DRSSLRQLHAAIKAAL 552 >gi|333989189|ref|YP_004521803.1| bifunctional 2-succinyl-6-hydroxy-24- cyclohexadiene-1-carboxylate synthase MenD [Mycobacterium sp. JDM601] gi|333485157|gb|AEF34549.1| bifunctional 2-succinyl-6-hydroxy-24- cyclohexadiene-1-carboxylate synthase MenD [Mycobacterium sp. JDM601] Length=549 Score = 893 bits (2307), Expect = 0.0, Method: Compositional matrix adjust. Identities = 474/553 (86%), Positives = 499/553 (91%), Gaps = 6/553 (1%) Query 2 NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYL 61 NPST QAR+VVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAGYL Sbjct 3 NPSTAQARIVVDELIRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRLHVRIDERTAGYL 62 Query 62 AIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTME 121 AIGLA+GAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTME Sbjct 63 AIGLAVGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTME 122 Query 122 QLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPL 181 QLGYFGTQVRA+ISLGLAEDAPER +ALNATWRSA CRVLAAA G+RTANAGPV FDIPL Sbjct 123 QLGYFGTQVRATISLGLAEDAPERMAALNATWRSAVCRVLAAANGSRTANAGPVQFDIPL 182 Query 182 REPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLA 241 REPLVP+P+ G++ PPGR G PWTYTPPVTFDQPLDIDL+ DTVVI+GHGAG HPNLA Sbjct 183 REPLVPEPDDSGSL-PPGRRGGLPWTYTPPVTFDQPLDIDLTPDTVVIAGHGAGTHPNLA 241 Query 242 ALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTG 301 ALPTVAEPTAP + +PLHPLALPLLRPQQVIM GRPTLHRPVS LLAD VPVFALTTG Sbjct 242 ALPTVAEPTAP-APQHPLHPLALPLLRPQQVIMAGRPTLHRPVSALLADPSVPVFALTTG 300 Query 302 PRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAA 361 PRWPDVSGNSQATGTRAVTTG P AWL RCA +N A AAVR+QLAAHPLTTGLHVAAA Sbjct 301 PRWPDVSGNSQATGTRAVTTGQPDAAWLRRCAELNASANAAVRDQLAAHPLTTGLHVAAA 360 Query 362 VSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGA 421 V+ ALRPGDQLVLGASNPVRD AL G G+ VRSNRGVAGIDGTVSTAIGAALA+ Sbjct 361 VTDALRPGDQLVLGASNPVRDAALVGFAADGVVVRSNRGVAGIDGTVSTAIGAALAF--- 417 Query 422 HERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQG 481 ERT + P RTIALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFELLEQG Sbjct 418 -ERTQTGSDPGRTIALIGDLTFVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELLEQG 476 Query 482 DPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRS 541 DPRF+DVSSRIFGTPHDVDVGALCRAYHVESRQIEV++LG L +P GMRVLEVKADRS Sbjct 477 DPRFADVSSRIFGTPHDVDVGALCRAYHVESRQIEVEQLGAALAEPAGGMRVLEVKADRS 536 Query 542 SLRQLHAAIKAAL 554 SLR LHAAIKAAL Sbjct 537 SLRALHAAIKAAL 549 >gi|120401990|ref|YP_951819.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium vanbaalenii PYR-1] gi|119954808|gb|ABM11813.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium vanbaalenii PYR-1] Length=549 Score = 880 bits (2275), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/558 (83%), Positives = 486/558 (88%), Gaps = 14/558 (2%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPST QARVVVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAG+ Sbjct 2 VNPSTAQARVVVDELIRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRLHVRIDERTAGF 61 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQT Sbjct 62 LAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTF 121 Query 121 EQLGYFGTQVRASISLGLAEDAPERT---SALNATWRSATCRVLAAATGARTANAGPVHF 177 EQLGYFGTQVRA+ISLGLA ++ SALN WRSATCRV+ AATGAR+ANAGPV F Sbjct 122 EQLGYFGTQVRANISLGLAPESGASALNFSALNGQWRSATCRVVVAATGARSANAGPVQF 181 Query 178 DIPLREPLVPD-PEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGV 236 DIPLREPLVPD EP P GRP G+PWTYTPPVTFDQPLDIDL+ DTVVI+GHGAGV Sbjct 182 DIPLREPLVPDAQEPAVPYAPDGRPDGRPWTYTPPVTFDQPLDIDLTPDTVVIAGHGAGV 241 Query 237 HPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVF 296 HPNLA LPTVAEPTAP + PLHPLAL ++RP+QVIMLGRPTLHRPVS LLAD VPVF Sbjct 242 HPNLAHLPTVAEPTAP-AAQTPLHPLALRMIRPEQVIMLGRPTLHRPVSALLADPAVPVF 300 Query 297 ALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGL 356 ALTTGPRWPDVSGNSQATGTRAVT GAP AWL RCA NRHA+ AVR QLAAHPLTTGL Sbjct 301 ALTTGPRWPDVSGNSQATGTRAVTAGAPAQAWLRRCAEANRHAVDAVRGQLAAHPLTTGL 360 Query 357 HVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAAL 416 HVAAAV+ ALRPGDQLVLGASNPVRD+AL G T ++VRSNRGVAGIDGTVSTAIGAAL Sbjct 361 HVAAAVADALRPGDQLVLGASNPVRDIALVGFHTADVKVRSNRGVAGIDGTVSTAIGAAL 420 Query 417 AYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFE 476 AHER+G RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFE Sbjct 421 ----AHERSGG-----RTVALIGDLTFVHDSSGLLIGPTEPTPRKLTIVVSNDNGGGIFE 471 Query 477 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEV 536 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEV EL LD+ GMRVLEV Sbjct 472 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVGELAGALDEDFDGMRVLEV 531 Query 537 KADRSSLRQLHAAIKAAL 554 KADRSSLR LHA+I+A L Sbjct 532 KADRSSLRALHASIRANL 549 >gi|118471524|ref|YP_885503.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium smegmatis str. MC2 155] gi|118172811|gb|ABK73707.1| 2-oxoglutarate decarboxylase [Mycobacterium smegmatis str. MC2 155] Length=547 Score = 880 bits (2275), Expect = 0.0, Method: Compositional matrix adjust. Identities = 454/559 (82%), Positives = 485/559 (87%), Gaps = 18/559 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPSTTQAR+VVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GRIRLHVRIDERTAGY Sbjct 2 VNPSTTQARIVVDELIRGGVRDVVLCPGSRNAPLAFALSDADRAGRIRLHVRIDERTAGY 61 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVC+AMTSGTAVANLGPAVVEANYARVPLIVLSANRPYE+LGTGANQT Sbjct 62 LAIGLAVAERAPVCIAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYEMLGTGANQTF 121 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSA----LNATWRSATCRVLAAATGARTANAGPVH 176 EQLGYFGTQVRA+ISLGLA D +A LNA WRSATCRVL AATGAR+ANAGPV Sbjct 122 EQLGYFGTQVRAAISLGLAPDLTGPNAADLDTLNAQWRSATCRVLVAATGARSANAGPVQ 181 Query 177 FDIPLREPLVPDP-EPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAG 235 FDIPLREPLVPDP EP G PPGRP G+ WT+TPPVTFDQPLDIDL+ DTVVI+GHGAG Sbjct 182 FDIPLREPLVPDPAEPAGGTIPPGRPGGRSWTHTPPVTFDQPLDIDLTPDTVVIAGHGAG 241 Query 236 VHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPV 295 HPNLA LPTVAEPTAP NPLHPLAL L P+QVIMLGRPTLHRPVS LLAD VPV Sbjct 242 EHPNLAELPTVAEPTAPPPA-NPLHPLALRLAHPKQVIMLGRPTLHRPVSTLLADPSVPV 300 Query 296 FALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTG 355 +ALTTGPRWPDVSGNSQATGTRAVT+GAP AWL +CA +N HA+ AVR+QLAAHP+TTG Sbjct 301 YALTTGPRWPDVSGNSQATGTRAVTSGAPSAAWLRKCAELNEHAVTAVRKQLAAHPMTTG 360 Query 356 LHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAA 415 LHVAAAV+ ALRPGDQLVLGASNPVRD AL GL GI+VRSNRGVAGIDGT+STAIGAA Sbjct 361 LHVAAAVADALRPGDQLVLGASNPVRDAALVGLRPDGIKVRSNRGVAGIDGTISTAIGAA 420 Query 416 LAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIF 475 LA++G RT+ALIGDLTFVHDSSGLLIGPTEP PRSLTIVVSNDNGGGIF Sbjct 421 LAHDG------------RTVALIGDLTFVHDSSGLLIGPTEPTPRSLTIVVSNDNGGGIF 468 Query 476 ELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLE 535 ELLEQGDPRFSDVSSRIFGTPHDV++GALC AYHV+ QIE D LG L+ P GMRVLE Sbjct 469 ELLEQGDPRFSDVSSRIFGTPHDVNIGALCHAYHVDYHQIEADALGAALEDPFQGMRVLE 528 Query 536 VKADRSSLRQLHAAIKAAL 554 VKADRSSLR LHA+IKAAL Sbjct 529 VKADRSSLRSLHASIKAAL 547 >gi|193806140|sp|A1T3R3.2|MEND_MYCVP RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD Length=548 Score = 879 bits (2271), Expect = 0.0, Method: Compositional matrix adjust. Identities = 459/558 (83%), Positives = 486/558 (88%), Gaps = 14/558 (2%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARVVVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAG+ Sbjct 1 MNPSTAQARVVVDELIRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQT Sbjct 61 LAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTF 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERT---SALNATWRSATCRVLAAATGARTANAGPVHF 177 EQLGYFGTQVRA+ISLGLA ++ SALN WRSATCRV+ AATGAR+ANAGPV F Sbjct 121 EQLGYFGTQVRANISLGLAPESGASALNFSALNGQWRSATCRVVVAATGARSANAGPVQF 180 Query 178 DIPLREPLVPD-PEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGV 236 DIPLREPLVPD EP P GRP G+PWTYTPPVTFDQPLDIDL+ DTVVI+GHGAGV Sbjct 181 DIPLREPLVPDAQEPAVPYAPDGRPDGRPWTYTPPVTFDQPLDIDLTPDTVVIAGHGAGV 240 Query 237 HPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVF 296 HPNLA LPTVAEPTAP + PLHPLAL ++RP+QVIMLGRPTLHRPVS LLAD VPVF Sbjct 241 HPNLAHLPTVAEPTAP-AAQTPLHPLALRMIRPEQVIMLGRPTLHRPVSALLADPAVPVF 299 Query 297 ALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGL 356 ALTTGPRWPDVSGNSQATGTRAVT GAP AWL RCA NRHA+ AVR QLAAHPLTTGL Sbjct 300 ALTTGPRWPDVSGNSQATGTRAVTAGAPAQAWLRRCAEANRHAVDAVRGQLAAHPLTTGL 359 Query 357 HVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAAL 416 HVAAAV+ ALRPGDQLVLGASNPVRD+AL G T ++VRSNRGVAGIDGTVSTAIGAAL Sbjct 360 HVAAAVADALRPGDQLVLGASNPVRDIALVGFHTADVKVRSNRGVAGIDGTVSTAIGAAL 419 Query 417 AYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFE 476 AHER+G RT+ALIGDLTFVHDSSGLLIGPTEP PR LTIVVSNDNGGGIFE Sbjct 420 ----AHERSGG-----RTVALIGDLTFVHDSSGLLIGPTEPTPRKLTIVVSNDNGGGIFE 470 Query 477 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEV 536 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEV EL LD+ GMRVLEV Sbjct 471 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVGELAGALDEDFDGMRVLEV 530 Query 537 KADRSSLRQLHAAIKAAL 554 KADRSSLR LHA+I+A L Sbjct 531 KADRSSLRALHASIRANL 548 >gi|193806133|sp|A0QRG5.2|MEND_MYCS2 RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD Length=546 Score = 878 bits (2268), Expect = 0.0, Method: Compositional matrix adjust. Identities = 453/559 (82%), Positives = 485/559 (87%), Gaps = 18/559 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQAR+VVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARIVVDELIRGGVRDVVLCPGSRNAPLAFALSDADRAGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVC+AMTSGTAVANLGPAVVEANYARVPLIVLSANRPYE+LGTGANQT Sbjct 61 LAIGLAVAERAPVCIAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYEMLGTGANQTF 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSA----LNATWRSATCRVLAAATGARTANAGPVH 176 EQLGYFGTQVRA+ISLGLA D +A LNA WRSATCRVL AATGAR+ANAGPV Sbjct 121 EQLGYFGTQVRAAISLGLAPDLTGPNAADLDTLNAQWRSATCRVLVAATGARSANAGPVQ 180 Query 177 FDIPLREPLVPDP-EPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAG 235 FDIPLREPLVPDP EP G PPGRP G+ WT+TPPVTFDQPLDIDL+ DTVVI+GHGAG Sbjct 181 FDIPLREPLVPDPAEPAGGTIPPGRPGGRSWTHTPPVTFDQPLDIDLTPDTVVIAGHGAG 240 Query 236 VHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPV 295 HPNLA LPTVAEPTAP NPLHPLAL L P+QVIMLGRPTLHRPVS LLAD VPV Sbjct 241 EHPNLAELPTVAEPTAPPPA-NPLHPLALRLAHPKQVIMLGRPTLHRPVSTLLADPSVPV 299 Query 296 FALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTG 355 +ALTTGPRWPDVSGNSQATGTRAVT+GAP AWL +CA +N HA+ AVR+QLAAHP+TTG Sbjct 300 YALTTGPRWPDVSGNSQATGTRAVTSGAPSAAWLRKCAELNEHAVTAVRKQLAAHPMTTG 359 Query 356 LHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAA 415 LHVAAAV+ ALRPGDQLVLGASNPVRD AL GL GI+VRSNRGVAGIDGT+STAIGAA Sbjct 360 LHVAAAVADALRPGDQLVLGASNPVRDAALVGLRPDGIKVRSNRGVAGIDGTISTAIGAA 419 Query 416 LAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIF 475 LA++G RT+ALIGDLTFVHDSSGLLIGPTEP PRSLTIVVSNDNGGGIF Sbjct 420 LAHDG------------RTVALIGDLTFVHDSSGLLIGPTEPTPRSLTIVVSNDNGGGIF 467 Query 476 ELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLE 535 ELLEQGDPRFSDVSSRIFGTPHDV++GALC AYHV+ QIE D LG L+ P GMRVLE Sbjct 468 ELLEQGDPRFSDVSSRIFGTPHDVNIGALCHAYHVDYHQIEADALGAALEDPFQGMRVLE 527 Query 536 VKADRSSLRQLHAAIKAAL 554 VKADRSSLR LHA+IKAAL Sbjct 528 VKADRSSLRSLHASIKAAL 546 >gi|126433356|ref|YP_001069047.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium sp. JLS] gi|193806091|sp|A3PUH9.1|MEND_MYCSJ RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|126233156|gb|ABN96556.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium sp. JLS] Length=547 Score = 865 bits (2234), Expect = 0.0, Method: Compositional matrix adjust. Identities = 453/558 (82%), Positives = 492/558 (89%), Gaps = 15/558 (2%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARVVVDEL+RGGV DVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAG+ Sbjct 1 MNPSTAQARVVVDELVRGGVHDVVLCPGSRNAPLAFALADADRAGRLRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQT Sbjct 61 LAIGLAVADRAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTF 120 Query 121 EQLGYFGTQVRASISLGLAED----APERTSALNATWRSATCRVLAAATGARTANAGPVH 176 EQLGYFG QVRA+ISLGLA + +P ++LNA WRSATCRV+ AATG+R+ANAGPV Sbjct 121 EQLGYFGNQVRANISLGLAPELSAGSPGDMTSLNAQWRSATCRVVVAATGSRSANAGPVQ 180 Query 177 FDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGV 236 FDIPLREPLVP + G+ PPGRP GKPWT+TPPVTFDQPLDIDL+ DTVVI+GHGAGV Sbjct 181 FDIPLREPLVPTFDDDGSC-PPGRPDGKPWTHTPPVTFDQPLDIDLTPDTVVIAGHGAGV 239 Query 237 HPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVF 296 HPNLA LPTVAEPTAP + NPLHP+AL LLRP+QVIMLGRPTLHRPVS LLAD VPV+ Sbjct 240 HPNLADLPTVAEPTAPPAA-NPLHPMALRLLRPKQVIMLGRPTLHRPVSALLADPSVPVY 298 Query 297 ALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGL 356 ALTTGPRWPDVSGNSQATGTRAVT+G P PAWL RC +N HA+AAVREQLAAHPLTTGL Sbjct 299 ALTTGPRWPDVSGNSQATGTRAVTSGTPDPAWLRRCKEVNDHAVAAVREQLAAHPLTTGL 358 Query 357 HVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAAL 416 HVAAAV+ A+RPGDQLVLGASNPVRD AL G G++VRSNRGVAGIDGTVSTAIGAAL Sbjct 359 HVAAAVADAVRPGDQLVLGASNPVRDAALVGFTPHGVQVRSNRGVAGIDGTVSTAIGAAL 418 Query 417 AYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFE 476 AH+RTG RTIAL+GDLTFVHDSSGLLIGPTEP PR+LTIVVSNDNGGGIFE Sbjct 419 ----AHDRTGG-----RTIALMGDLTFVHDSSGLLIGPTEPTPRNLTIVVSNDNGGGIFE 469 Query 477 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEV 536 LLEQGDPRFSDVSSR+FGTPHDVDVGALCRAYHV++RQIEV +L LD+P GMRVLEV Sbjct 470 LLEQGDPRFSDVSSRVFGTPHDVDVGALCRAYHVDNRQIEVGQLADALDEPHEGMRVLEV 529 Query 537 KADRSSLRQLHAAIKAAL 554 KADRSSLR LHA+IKAAL Sbjct 530 KADRSSLRALHASIKAAL 547 >gi|108797730|ref|YP_637927.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium sp. MCS] gi|119866819|ref|YP_936771.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium sp. KMS] gi|123070656|sp|Q1BE13.1|MEND_MYCSS RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|193806092|sp|A1UAX3.1|MEND_MYCSK RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|108768149|gb|ABG06871.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium sp. MCS] gi|119692908|gb|ABL89981.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium sp. KMS] Length=547 Score = 864 bits (2233), Expect = 0.0, Method: Compositional matrix adjust. Identities = 453/558 (82%), Positives = 492/558 (89%), Gaps = 15/558 (2%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARVVVDEL+RGGV DVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAG+ Sbjct 1 MNPSTAQARVVVDELVRGGVHDVVLCPGSRNAPLAFALADADRAGRLRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQT Sbjct 61 LAIGLAVADRAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTF 120 Query 121 EQLGYFGTQVRASISLGLAED----APERTSALNATWRSATCRVLAAATGARTANAGPVH 176 EQLGYFG QVRA+ISLGLA + +P ++LNA WRSATCRV+ AATG+R+ANAGPV Sbjct 121 EQLGYFGNQVRANISLGLAPELSSGSPGDMTSLNAQWRSATCRVVVAATGSRSANAGPVQ 180 Query 177 FDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGV 236 FDIPLREPLVP + G+ PPGRP GKPWT+TPPVTFDQPLDIDL+ DTVVI+GHGAGV Sbjct 181 FDIPLREPLVPTFDDDGSC-PPGRPDGKPWTHTPPVTFDQPLDIDLTPDTVVIAGHGAGV 239 Query 237 HPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVF 296 HPNLA LPTVAEPTAP + NPLHP+AL LLRP+QVIMLGRPTLHRPVS LLAD VPV+ Sbjct 240 HPNLADLPTVAEPTAPPAA-NPLHPMALRLLRPKQVIMLGRPTLHRPVSALLADPSVPVY 298 Query 297 ALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGL 356 ALTTGPRWPDVSGNSQATGTRAVT+G P PAWL RC +N HA+AAVREQLAAHPLTTGL Sbjct 299 ALTTGPRWPDVSGNSQATGTRAVTSGTPDPAWLRRCKEVNDHAVAAVREQLAAHPLTTGL 358 Query 357 HVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAAL 416 HVAAAV+ A+RPGDQLVLGASNPVRD AL G G++VRSNRGVAGIDGTVSTAIGAAL Sbjct 359 HVAAAVADAVRPGDQLVLGASNPVRDAALVGFTPHGVQVRSNRGVAGIDGTVSTAIGAAL 418 Query 417 AYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFE 476 AH+RTG RTIAL+GDLTFVHDSSGLLIGPTEP PR+LTIVVSNDNGGGIFE Sbjct 419 ----AHDRTGG-----RTIALMGDLTFVHDSSGLLIGPTEPTPRNLTIVVSNDNGGGIFE 469 Query 477 LLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEV 536 LLEQGDPRFSDVSSR+FGTPHDVDVGALCRAYHV++RQIEV +L LD+P GMRVLEV Sbjct 470 LLEQGDPRFSDVSSRVFGTPHDVDVGALCRAYHVDNRQIEVGQLADALDEPHEGMRVLEV 529 Query 537 KADRSSLRQLHAAIKAAL 554 KADRSSLR LHA+IKAAL Sbjct 530 KADRSSLRALHASIKAAL 547 >gi|145225837|ref|YP_001136515.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium gilvum PYR-GCK] gi|315442455|ref|YP_004075334.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium sp. Spyr1] gi|145218323|gb|ABP47727.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium gilvum PYR-GCK] gi|315260758|gb|ADT97499.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Mycobacterium sp. Spyr1] Length=545 Score = 843 bits (2178), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/554 (81%), Positives = 478/554 (87%), Gaps = 10/554 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPST QARVVVDEL+RGGVRDVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAG+ Sbjct 2 VNPSTAQARVVVDELVRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRLHVRIDERTAGF 61 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVCVAMTSGTAVANLGPAVVEANYARVPLIVL+ANRPYELLGTGANQT Sbjct 62 LAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLTANRPYELLGTGANQTF 121 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVR SISLGLA D + S LNA WRSATCRVL AA G+R+ANAGPV FDIP Sbjct 122 EQLGYFGTQVRESISLGLAGDHADMGS-LNAQWRSATCRVLVAAKGSRSANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD + A P GRP GK WTYTP VTFDQPL+IDL+ DTVVI+GHGAGVHPNL Sbjct 181 LREPLVPDADDGSAYAPEGRPGGKEWTYTPAVTFDQPLEIDLTPDTVVIAGHGAGVHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP + PLHPLAL L+RP+QVIMLGRPTLHR VS LLAD VPVFALTT Sbjct 241 AHLPTVAEPTAPYA-QTPLHPLALSLIRPRQVIMLGRPTLHRSVSTLLADPAVPVFALTT 299 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVT+GA P WL RCA +NRHA+ AVR QLAAHPLTTGLHVAA Sbjct 300 GPRWPDVSGNSQATGTRAVTSGAASPEWLRRCAEVNRHAVEAVRGQLAAHPLTTGLHVAA 359 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 V+ A+ PGDQLVLGASNPVRD+AL G +T ++VRSNRGVAGIDGTVSTAIGAALA+E Sbjct 360 VVADAVGPGDQLVLGASNPVRDIALVGFNTADVKVRSNRGVAGIDGTVSTAIGAALAHER 419 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 A TG RT+ALIGDLTFVHDSSGLL+GPTEP PR LTIVVSNDNGGGIFELLEQ Sbjct 420 A---TGG-----RTVALIGDLTFVHDSSGLLVGPTEPTPRKLTIVVSNDNGGGIFELLEQ 471 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVES QIE EL L + GMRVLEVKADR Sbjct 472 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESTQIEAGELAAALAEDFDGMRVLEVKADR 531 Query 541 SSLRQLHAAIKAAL 554 SSLR LHA+IKA L Sbjct 532 SSLRALHASIKAGL 545 >gi|169631012|ref|YP_001704661.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium abscessus ATCC 19977] gi|254810346|sp|B1MHC6.1|MEND_MYCA9 RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|169242979|emb|CAM64007.1| Probable bifunctional menaquinone biosynthesis protein MenD [Mycobacterium abscessus] Length=540 Score = 843 bits (2178), Expect = 0.0, Method: Compositional matrix adjust. Identities = 430/554 (78%), Positives = 475/554 (86%), Gaps = 14/554 (2%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDELIRGGVRDVVLCPGSRNAPLAFAL DAD++GR+RLHVRIDERTAG+ Sbjct 1 MNPSTAQAHAVVDELIRGGVRDVVLCPGSRNAPLAFALHDADKAGRLRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA +G+PV VAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAVGLAAASGSPVPVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+IS+GLAE+ E+ A N WRSATCRVLAAA G+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRAAISIGLAEEGSEKIEAQNPHWRSATCRVLAAAKGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD + G P GRP G PWTYTP VTFD+P++IDL+ DTVVI+GHGA HPNL Sbjct 181 LREPLVPDRD--GGPIPAGRPGGAPWTYTPDVTFDEPVEIDLTADTVVIAGHGAATHPNL 238 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 + LPTVAEPTAP+ DNP+HPLAL LL PQQVIMLGRPTLHR VS LLAD+ +PV+ALTT Sbjct 239 SMLPTVAEPTAPQP-DNPVHPLALTLLHPQQVIMLGRPTLHRQVSSLLADSRIPVYALTT 297 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVT+G+P PAWL RCA + A+ AVR QL+ HPLTTGLHVAA Sbjct 298 GPRWPDVSGNSQATGTRAVTSGSPDPAWLQRCAHAHHKALDAVRGQLSTHPLTTGLHVAA 357 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 V +LR GDQLVLGASNPVRD AL + +RVRSNRGVAGIDGTVSTAIGAALA+ G Sbjct 358 HVCGSLRDGDQLVLGASNPVRDAALVPWGAKDVRVRSNRGVAGIDGTVSTAIGAALAHRG 417 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 RT+ALIGDLTFVHDSSGLLIGPTEP P +LTIVVSNDNGGGIFELLEQ Sbjct 418 G-----------RTVALIGDLTFVHDSSGLLIGPTEPRPENLTIVVSNDNGGGIFELLEQ 466 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRF DVSSRIFGTPHDVD+ ALCRAYHV+S+ I V+ELGP LD+P G+RVLEVKADR Sbjct 467 GDPRFHDVSSRIFGTPHDVDIAALCRAYHVDSQSISVEELGPALDEPARGIRVLEVKADR 526 Query 541 SSLRQLHAAIKAAL 554 S+LR+LHAAI+AAL Sbjct 527 STLRELHAAIRAAL 540 >gi|193806146|sp|A4T174.2|MEND_MYCGI RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD Length=544 Score = 842 bits (2174), Expect = 0.0, Method: Compositional matrix adjust. Identities = 447/554 (81%), Positives = 478/554 (87%), Gaps = 10/554 (1%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARVVVDEL+RGGVRDVVLCPGSRNAPLAFAL DADR+GR+RLHVRIDERTAG+ Sbjct 1 MNPSTAQARVVVDELVRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRLHVRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ APVCVAMTSGTAVANLGPAVVEANYARVPLIVL+ANRPYELLGTGANQT Sbjct 61 LAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLTANRPYELLGTGANQTF 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVR SISLGLA D + S LNA WRSATCRVL AA G+R+ANAGPV FDIP Sbjct 121 EQLGYFGTQVRESISLGLAGDHADMGS-LNAQWRSATCRVLVAAKGSRSANAGPVQFDIP 179 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD + A P GRP GK WTYTP VTFDQPL+IDL+ DTVVI+GHGAGVHPNL Sbjct 180 LREPLVPDADDGSAYAPEGRPGGKEWTYTPAVTFDQPLEIDLTPDTVVIAGHGAGVHPNL 239 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP + PLHPLAL L+RP+QVIMLGRPTLHR VS LLAD VPVFALTT Sbjct 240 AHLPTVAEPTAPYA-QTPLHPLALSLIRPRQVIMLGRPTLHRSVSTLLADPAVPVFALTT 298 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGNSQATGTRAVT+GA P WL RCA +NRHA+ AVR QLAAHPLTTGLHVAA Sbjct 299 GPRWPDVSGNSQATGTRAVTSGAASPEWLRRCAEVNRHAVEAVRGQLAAHPLTTGLHVAA 358 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 V+ A+ PGDQLVLGASNPVRD+AL G +T ++VRSNRGVAGIDGTVSTAIGAALA+E Sbjct 359 VVADAVGPGDQLVLGASNPVRDIALVGFNTADVKVRSNRGVAGIDGTVSTAIGAALAHER 418 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 A TG RT+ALIGDLTFVHDSSGLL+GPTEP PR LTIVVSNDNGGGIFELLEQ Sbjct 419 A---TGG-----RTVALIGDLTFVHDSSGLLVGPTEPTPRKLTIVVSNDNGGGIFELLEQ 470 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVES QIE EL L + GMRVLEVKADR Sbjct 471 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESTQIEAGELAAALAEDFDGMRVLEVKADR 530 Query 541 SSLRQLHAAIKAAL 554 SSLR LHA+IKA L Sbjct 531 SSLRALHASIKAGL 544 >gi|226305193|ref|YP_002765151.1| menaquinone biosynthesis protein MenD [Rhodococcus erythropolis PR4] gi|259495571|sp|C0ZV17.1|MEND_RHOE4 RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|226184308|dbj|BAH32412.1| menaquinone biosynthesis protein MenD [Rhodococcus erythropolis PR4] Length=537 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/554 (69%), Positives = 428/554 (78%), Gaps = 17/554 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDEL+RGGVR+VVLCPGSRNAPLAFALQ AD GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQATAVVDELVRGGVREVVLCPGSRNAPLAFALQAADLDGRLRLHMRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLAI PV + MTSGTAVANLGPAV+EANYARVPL+VLSANRPYE+LGTGANQT+ Sbjct 61 LALGLAIAGKRPVPIVMTSGTAVANLGPAVLEANYARVPLVVLSANRPYEMLGTGANQTV 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FG+QVRA+ISLGLAED S N+ WRSA CRVLAAA G R+ NAGPVHFDIP Sbjct 121 EQLGLFGSQVRATISLGLAED----DSTQNSQWRSAVCRVLAAARGTRSGNAGPVHFDIP 176 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD G V P GRP G WT T T D P+D+DL+ DTVVISGHG+ + P L Sbjct 177 LREPLVPDVHVHGPV-PEGRPGGAAWTTTQNATLDVPVDLDLTADTVVISGHGSALRPEL 235 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP G LHPLAL L+P+Q I+ GRPTLHR VS +LAD V V+ALTT Sbjct 236 AGLPTVAEPTAPMHG-IALHPLALSQLKPKQAIITGRPTLHRQVSKVLADPSVDVYALTT 294 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGN ATGTRAV TG P PAW+ RCAA+ HA AVR+QL AHP TGLHVAA Sbjct 295 GPRWPDVSGNVLATGTRAVVTGTPDPAWIARCAALTEHAETAVRKQLDAHPKATGLHVAA 354 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV AL GDQL+LGASNPVRD AL +RV SNRGVAGIDGTVS A+GAALAYEG Sbjct 355 AVMDALADGDQLLLGASNPVRDAALVSYPKPAVRVLSNRGVAGIDGTVSAAVGAALAYEG 414 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 RT+AL+GDLTF+HD+SGLLIG EP P LTIVV+ND+GGGIFELLEQ Sbjct 415 G-----------RTVALMGDLTFLHDASGLLIGTGEPRPSDLTIVVANDDGGGIFELLEQ 463 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDP+++ V R+FGTPH +D+ ALC AY V + VD L TL QP G+RVLEV DR Sbjct 464 GDPQYAGVFERVFGTPHGMDLAALCAAYRVPHAAVTVDALATTLAQPANGIRVLEVATDR 523 Query 541 SSLRQLHAAIKAAL 554 S LR+LHA+++A L Sbjct 524 SGLRELHASVRAQL 537 >gi|229490730|ref|ZP_04384568.1| 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase [Rhodococcus erythropolis SK121] gi|229322550|gb|EEN88333.1| 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase [Rhodococcus erythropolis SK121] Length=537 Score = 719 bits (1857), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/554 (69%), Positives = 428/554 (78%), Gaps = 17/554 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDEL+RGGVR+VVLCPGSRNAPLAFALQ AD GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQATAVVDELVRGGVREVVLCPGSRNAPLAFALQAADLDGRLRLHMRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLAI PV + MTSGTAVANLGPAV+EANYARVPL+VLSANRPYE+LGTGANQT+ Sbjct 61 LALGLAIAGKRPVPIVMTSGTAVANLGPAVLEANYARVPLVVLSANRPYEMLGTGANQTV 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FG+QVRA+ISLGLAED S N+ WRSA CRVLAAA G R+ NAGPVHFDIP Sbjct 121 EQLGLFGSQVRATISLGLAED----DSTQNSQWRSAVCRVLAAARGTRSGNAGPVHFDIP 176 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD G V P GRP G WT T T D P+D+DL+ DTVVISGHG+ + P L Sbjct 177 LREPLVPDVHVQGPV-PEGRPGGAAWTTTQNATLDVPVDLDLTADTVVISGHGSALRPEL 235 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP G LHPLAL L+P+Q I+ GRPTLHR VS +LAD V V+ALTT Sbjct 236 AGLPTVAEPTAPMHG-IALHPLALSQLKPKQAIITGRPTLHRQVSKVLADPGVDVYALTT 294 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGN ATGTRAV TG P PAW+ RCAA+ HA AVR+QL AHP TGLHVAA Sbjct 295 GPRWPDVSGNVLATGTRAVVTGTPDPAWIARCAALTEHAETAVRKQLDAHPKATGLHVAA 354 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV AL GDQL+LGASNPVRD AL +RV SNRGVAGIDGTVS A+GAALAYEG Sbjct 355 AVMDALADGDQLLLGASNPVRDAALVSYPKPAVRVLSNRGVAGIDGTVSAAVGAALAYEG 414 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 RT+AL+GDLTF+HD+SGLLIG EP P LTIVV+ND+GGGIFELLEQ Sbjct 415 G-----------RTVALMGDLTFLHDASGLLIGTGEPRPSDLTIVVANDDGGGIFELLEQ 463 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR 540 GDP+++ V R+FGTPH +D+ ALC AY V + VD L TL QP G+RVLEV DR Sbjct 464 GDPQYAGVFERVFGTPHGMDLAALCAAYRVPHAAVTVDALATTLAQPANGIRVLEVATDR 523 Query 541 SSLRQLHAAIKAAL 554 S LR+LHA+++A L Sbjct 524 SGLRELHASVRAQL 537 >gi|325675334|ref|ZP_08155018.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Rhodococcus equi ATCC 33707] gi|325553305|gb|EGD22983.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Rhodococcus equi ATCC 33707] Length=548 Score = 712 bits (1839), Expect = 0.0, Method: Compositional matrix adjust. Identities = 381/560 (69%), Positives = 437/560 (79%), Gaps = 18/560 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDELIRGGVR+VVLCPGSRNAPLAFALQ AD +GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQATAVVDELIRGGVREVVLCPGSRNAPLAFALQAADAAGRLRLHLRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ +G PV V MTSGTAVANLGPAV+EANYAR+PLIVLSANRPYE+LGTGANQT+ Sbjct 61 LAIGLAVASGQPVPVVMTSGTAVANLGPAVLEANYARIPLIVLSANRPYEMLGTGANQTV 120 Query 121 EQLGYFGTQVRASISLGLAEDAPE------RTSALNATWRSATCRVLAAATGARTANAGP 174 EQ G FG+QVRA+ISLGLAE+A + R N+ WRSA CRVLAAA G R+ NAGP Sbjct 121 EQFGLFGSQVRAAISLGLAEEAGDESQRGIRFDEQNSQWRSAVCRVLAAARGTRSGNAGP 180 Query 175 VHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGA 234 VHFDIPLREPLVPD P G V P GRP G WT T T D P+D+D++ DTVV+SGHG+ Sbjct 181 VHFDIPLREPLVPDVRPQGLV-PEGRPGGAAWTTTVHATLDVPMDLDITADTVVVSGHGS 239 Query 235 GVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVP 294 P LA LPTVAEPTAP G PLHPLALP L+P+Q I+ GRPTLHRPVS LLAD V Sbjct 240 AYRPELAGLPTVAEPTAPLHG-IPLHPLALPQLKPRQAIITGRPTLHRPVSKLLADPSVA 298 Query 295 VFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTT 354 V+ALTTGPRWPDVSGN ATGTRAV TG P PAW+ RC ++ HA AVR QL AHP T Sbjct 299 VYALTTGPRWPDVSGNVLATGTRAVVTGEPDPAWIARCRHLSEHADKAVRSQLDAHPTAT 358 Query 355 GLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGA 414 GLHVAAAV AL GDQL+LGASNPVRD AL G++V SNRGVAGIDGTVSTA+GA Sbjct 359 GLHVAAAVMEALSDGDQLLLGASNPVRDAALVSYPRPGVKVLSNRGVAGIDGTVSTAVGA 418 Query 415 ALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGI 474 ALAYE S RT+AL+GDLTF+HD+SGLLIG EP P LTIVV+ND+GGGI Sbjct 419 ALAYE----------SEGRTVALLGDLTFLHDASGLLIGTGEPRPTDLTIVVANDDGGGI 468 Query 475 FELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVL 534 FELLEQGDP+++ V R+FGTPH +D+ ALC AY V R++++ EL L PG G+RVL Sbjct 469 FELLEQGDPQYAGVFERVFGTPHGMDLAALCAAYRVPHRRVDLAELTAVLTAPGDGIRVL 528 Query 535 EVKADRSSLRQLHAAIKAAL 554 EV +RS LR+LHAA++A L Sbjct 529 EVTTERSGLRELHAAVRAQL 548 >gi|312141029|ref|YP_004008365.1| 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase/ 2-oxoglutarate decarboxylase mend [Rhodococcus equi 103S] gi|311890368|emb|CBH49686.1| 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase/ 2-oxoglutarate decarboxylase MenD [Rhodococcus equi 103S] Length=548 Score = 712 bits (1838), Expect = 0.0, Method: Compositional matrix adjust. Identities = 381/560 (69%), Positives = 437/560 (79%), Gaps = 18/560 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDELIRGGVR+VVLCPGSRNAPLAFALQ AD +GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQATAVVDELIRGGVREVVLCPGSRNAPLAFALQAADAAGRLRLHLRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+ +G PV V MTSGTAVANLGPAV+EANYAR+PLIVLSANRPYE+LGTGANQT+ Sbjct 61 LAIGLAVASGQPVPVVMTSGTAVANLGPAVLEANYARIPLIVLSANRPYEMLGTGANQTV 120 Query 121 EQLGYFGTQVRASISLGLAEDAPE------RTSALNATWRSATCRVLAAATGARTANAGP 174 EQ G FG+QVRA+ISLGLAE+A + R N+ WRSA CRVLAAA G R+ NAGP Sbjct 121 EQFGLFGSQVRAAISLGLAEEAGDESQRGIRFDEQNSQWRSAVCRVLAAARGTRSGNAGP 180 Query 175 VHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGA 234 VHFDIPLREPLVPD P G V P GRP G WT T T D P+D+D++ DTVV+SGHG+ Sbjct 181 VHFDIPLREPLVPDVRPRGLV-PEGRPGGAAWTTTVHATLDVPMDLDITADTVVVSGHGS 239 Query 235 GVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVP 294 P LA LPTVAEPTAP G PLHPLALP L+P+Q I+ GRPTLHRPVS LLAD V Sbjct 240 AYRPELAGLPTVAEPTAPLHG-IPLHPLALPQLKPRQAIITGRPTLHRPVSKLLADPSVA 298 Query 295 VFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTT 354 V+ALTTGPRWPDVSGN ATGTRAV TG P PAW+ RC ++ HA AVR QL AHP T Sbjct 299 VYALTTGPRWPDVSGNVLATGTRAVVTGEPDPAWIARCRHLSEHADKAVRSQLDAHPTAT 358 Query 355 GLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGA 414 GLHVAAAV AL GDQL+LGASNPVRD AL G++V SNRGVAGIDGTVSTA+GA Sbjct 359 GLHVAAAVMEALSDGDQLLLGASNPVRDAALVSYPRPGVKVLSNRGVAGIDGTVSTAVGA 418 Query 415 ALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGI 474 ALAYE S RT+AL+GDLTF+HD+SGLLIG EP P LTIVV+ND+GGGI Sbjct 419 ALAYE----------SEGRTVALLGDLTFLHDASGLLIGTGEPRPTDLTIVVANDDGGGI 468 Query 475 FELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVL 534 FELLEQGDP+++ V R+FGTPH +D+ ALC AY V R++++ EL L PG G+RVL Sbjct 469 FELLEQGDPQYAGVFERVFGTPHGMDLAALCAAYRVPHRRVDLAELTAVLTAPGDGIRVL 528 Query 535 EVKADRSSLRQLHAAIKAAL 554 EV +RS LR+LHAA++A L Sbjct 529 EVTTERSGLRELHAAVRAQL 548 >gi|111018990|ref|YP_701962.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Rhodococcus jostii RHA1] gi|122955918|sp|Q0SF82.1|MEND_RHOSR RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|110818520|gb|ABG93804.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/ 2-oxoglutarate decarboxylase [Rhodococcus jostii RHA1] Length=541 Score = 704 bits (1816), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/558 (67%), Positives = 428/558 (77%), Gaps = 21/558 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDEL+RGGVR+VVLCPGSRNAPLAFALQ AD GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQATAVVDELVRGGVREVVLCPGSRNAPLAFALQAADLEGRLRLHMRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA+ PV + MTSGTAVANLGPAV+EANYARVPL+VLSANRPYE+LGTGANQT+ Sbjct 61 LALGLAVAGKRPVPIVMTSGTAVANLGPAVLEANYARVPLVVLSANRPYEMLGTGANQTI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FG+QVRA+ISLGLAED + N+ WRSA CRVLAAA G R+ NAGPVHFDIP Sbjct 121 EQLGLFGSQVRATISLGLAED----DAGQNSQWRSAVCRVLAAARGTRSGNAGPVHFDIP 176 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD G V P GRP G WT T T D P+D+DL+ DT+VISGHG+ + P L Sbjct 177 LREPLVPDVHAQGPV-PQGRPGGAAWTTTQHATLDVPMDLDLTPDTIVISGHGSALRPEL 235 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP G P+HP+ALP L+P+Q ++ GRPTLHR VS +LAD V V+ALTT Sbjct 236 AGLPTVAEPTAPLHG-IPVHPMALPQLKPRQAVITGRPTLHRSVSKVLADPSVAVYALTT 294 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGN ATGTRAV +G P AW++RC ++ H AVR QLAAHP TGLHVAA Sbjct 295 GPRWPDVSGNVLATGTRAVVSGEPDRAWINRCRTLSEHTDKAVRAQLAAHPKATGLHVAA 354 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV AL GDQL+LGASNPVRD AL IRV SNRGVAGIDGTVS A+GAALAYE Sbjct 355 AVMDALTDGDQLLLGASNPVRDAALVSYPAPKIRVLSNRGVAGIDGTVSAAVGAALAYEE 414 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 RT+AL+GDLTF+HD+SGLLIG EP PR LTIVV+ND+GGGIFELLEQ Sbjct 415 G-----------RTVALLGDLTFLHDASGLLIGSGEPRPRDLTIVVANDDGGGIFELLEQ 463 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGA----GMRVLEV 536 GDP+++ V R+FGTPH +D+ ALC AY VE + + EL L P A G+RVLEV Sbjct 464 GDPQYAGVFERVFGTPHGMDLAALCAAYRVEHHLVGLGELSTRLSAPEAPGDRGIRVLEV 523 Query 537 KADRSSLRQLHAAIKAAL 554 +RS LR+LHAA++A L Sbjct 524 TTERSGLRELHAAVRAQL 541 >gi|226361085|ref|YP_002778863.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Rhodococcus opacus B4] gi|254810353|sp|C1AYZ0.1|MEND_RHOOB RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|226239570|dbj|BAH49918.1| menaquinone biosynthesis protein MenD [Rhodococcus opacus B4] Length=541 Score = 703 bits (1814), Expect = 0.0, Method: Compositional matrix adjust. Identities = 369/558 (67%), Positives = 428/558 (77%), Gaps = 21/558 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA VVDEL+RGGVR+VVLCPGSRNAPLAFALQ AD GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQATAVVDELVRGGVREVVLCPGSRNAPLAFALQAADLEGRLRLHMRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA+ PV + MTSGTAVANLGPAV+EANYARVPL+VLSANRPYE+LGTGANQT+ Sbjct 61 LALGLAVAGKRPVPIVMTSGTAVANLGPAVLEANYARVPLVVLSANRPYEMLGTGANQTI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FG+QVRA+ISLGLAED + N+ WRSA CRVLAAA G R+ NAGPVHFDIP Sbjct 121 EQLGLFGSQVRATISLGLAED----DAGQNSQWRSAVCRVLAAARGTRSGNAGPVHFDIP 176 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPD G V P GRP G WT T T D +D+D++ DT+VISGHG+ + P L Sbjct 177 LREPLVPDVHAQGPV-PQGRPGGAAWTTTQHATLDVAMDLDITPDTIVISGHGSALRPEL 235 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP G P+HP+ALP L+P+Q ++ GRPTLHR VS +LAD V V+ALTT Sbjct 236 AGLPTVAEPTAPLHG-IPVHPMALPQLKPRQAVITGRPTLHRSVSKVLADPAVAVYALTT 294 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGN ATGTRAV TGAP AW++RC ++ H AVR QLAAHP TGLHVAA Sbjct 295 GPRWPDVSGNVLATGTRAVVTGAPDRAWINRCRTLSEHTDKAVRAQLAAHPKATGLHVAA 354 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV AL GDQL+LGASNPVRD AL +RV SNRGVAGIDGTVS A+GAALAYE Sbjct 355 AVMDALTDGDQLLLGASNPVRDAALVSYPAPKVRVLSNRGVAGIDGTVSAAVGAALAYEE 414 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 RT+AL+GDLTF+HD+SGLLIG EP PR LTIVV+ND+GGGIFELLEQ Sbjct 415 G-----------RTVALLGDLTFLHDASGLLIGSGEPRPRDLTIVVANDDGGGIFELLEQ 463 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGA----GMRVLEV 536 GDP+++ V R+FGTPH +D+ ALC AY VE + + EL L P A G+RVLEV Sbjct 464 GDPQYAGVFERVFGTPHGMDLAALCAAYRVEHHLVGLGELSTLLSTPDAPGDRGIRVLEV 523 Query 537 KADRSSLRQLHAAIKAAL 554 +RS LR+LHAA++A L Sbjct 524 TTERSGLRELHAAVRAQL 541 >gi|333918063|ref|YP_004491644.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Amycolicicoccus subflavus DQS3-9A1] gi|333480284|gb|AEF38844.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Amycolicicoccus subflavus DQS3-9A1] Length=555 Score = 684 bits (1766), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/557 (66%), Positives = 421/557 (76%), Gaps = 22/557 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPST QAR VVDELIRGGVRDVVLCPGSRNAPLAFAL A+ +GRIRLHVRIDERTAG+ Sbjct 10 VNPSTAQARAVVDELIRGGVRDVVLCPGSRNAPLAFALHTAETAGRIRLHVRIDERTAGF 69 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLA+G+ PV V MTSGTAVANL PAV EANYARVP+IVLSANRPYELLGTGANQT+ Sbjct 70 LAIGLALGSKQPVPVVMTSGTAVANLTPAVFEANYARVPMIVLSANRPYELLGTGANQTV 129 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FG QVRA ISLG+AE ++ N+ WRSA CRVLAAA G RT NAGPV FD+P Sbjct 130 EQLGMFGNQVRACISLGIAEADRDQ----NSQWRSAVCRVLAAARGDRTGNAGPVQFDLP 185 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVP P PPGR G+PWT TP FD PL IDLS DT+VISGHG+G HP L Sbjct 186 LREPLVPSPGE--GDEPPGREGGQPWTETPHTLFDIPLPIDLSRDTIVISGHGSGAHPEL 243 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 +PTVAEPTAP G P+HP AL LRPQQ I+ GRPTLHR VS +LAD +V V+ALTT Sbjct 244 DGMPTVAEPTAPVHG-FPVHPYALAELRPQQAIITGRPTLHRAVSSVLADPKVAVYALTT 302 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGN A GTRAV +G PR WL++ ++ A + ++LA HP +TGLHVA+ Sbjct 303 GPRWPDVSGNLTAAGTRAVISGTPRDEWLEQARVLSAAAFEVMDDELAHHPKSTGLHVAS 362 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 V + PGD L+LGASNPVRD ALAG G V SNRGVAGIDGTVSTAIGAA A+ G Sbjct 363 EVVRRVHPGDLLILGASNPVRDAALAGTVPPGASVVSNRGVAGIDGTVSTAIGAASAHGG 422 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 R IALIGDLTF+HDSSGLL+GP EP P+ LT+VV+ND+GGGIFELLEQ Sbjct 423 ------------RAIALIGDLTFLHDSSGLLLGPQEPRPQDLTVVVANDDGGGIFELLEQ 470 Query 481 GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGA---GMRVLEVK 537 GDP ++ RIFGTPH V+V A+C+AY V Q + D LG LD+ A G+RV+EV+ Sbjct 471 GDPVYAGAFERIFGTPHGVNVSAVCQAYGVPYIQTDADGLGAVLDRGAADTGGLRVVEVR 530 Query 538 ADRSSLRQLHAAIKAAL 554 DRS LR+LHAA++ + Sbjct 531 TDRSGLRELHAAVRNGI 547 >gi|343925610|ref|ZP_08765127.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Gordonia alkanivorans NBRC 16433] gi|343764400|dbj|GAA12053.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Gordonia alkanivorans NBRC 16433] Length=562 Score = 673 bits (1737), Expect = 0.0, Method: Compositional matrix adjust. Identities = 364/563 (65%), Positives = 423/563 (76%), Gaps = 22/563 (3%) Query 2 NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYL 61 NPST QARV+VDE+IRGGVR+ VLCPGSRNAPLAFAL AD +GR+RLHVRIDER+AGYL Sbjct 7 NPSTLQARVIVDEMIRGGVREAVLCPGSRNAPLAFALHAADATGRLRLHVRIDERSAGYL 66 Query 62 AIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTME 121 A+GLA+ + PV + MTSGTAVAN+GPAV EANYARVPL+V+SANRPYELLG+GANQT+E Sbjct 67 ALGLAVSSKEPVPIVMTSGTAVANMGPAVFEANYARVPLVVISANRPYELLGSGANQTVE 126 Query 122 QLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPL 181 Q G FGTQVRA+ISLGLA ER N+ WRSA RVLAAA GART NAGPV FDIPL Sbjct 127 QFGLFGTQVRAAISLGLA----ERDLDTNSQWRSAVGRVLAAARGARTGNAGPVQFDIPL 182 Query 182 REPLVPDPEPLG---AVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHP 238 REPLVPDP+ +G + GRP G PWT P D PL IDLS+DTVV+SGHG+G HP Sbjct 183 REPLVPDPDEVGDDDLGSFAGRPGGLPWTQAPVGKLDVPLPIDLSLDTVVVSGHGSGEHP 242 Query 239 NLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFAL 298 LA +PTVAEPTAP PLHPLAL +RP+Q I+ GRPTLHR VS LLAD EV V+AL Sbjct 243 ALADVPTVAEPTAPHPA-TPLHPLALDTVRPKQAIICGRPTLHRGVSRLLADPEVRVYAL 301 Query 299 TTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHV 358 TTGPRWPDVSGN ATGTR G PR W+ C A+ AV +L TTGLHV Sbjct 302 TTGPRWPDVSGNVFATGTRIEVVGEPREDWIKECGAVQERVAGAVEAELDEPGPTTGLHV 361 Query 359 AAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAY 418 A AVS A+ PGDQLV+GASNP+RD+ALAGL G+RV SNRGVAGIDGT STAIGAALA Sbjct 362 ARAVSAAMAPGDQLVVGASNPIRDIALAGLVAEGVRVLSNRGVAGIDGTNSTAIGAALAL 421 Query 419 EGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELL 478 + HER G+ RTIAL+GDLTF+HD++GL+IGP EP P SL IVV+ND+GGGIF LL Sbjct 422 D--HERPGA-----RTIALMGDLTFIHDATGLVIGPGEPRPDSLRIVVANDDGGGIFGLL 474 Query 479 EQGDPRFS-----DVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTL-DQPGA-GM 531 EQGDPR++ R+FGTPH D+ ++C +H+ R++ VDEL L + P A G+ Sbjct 475 EQGDPRYNAGQYAGAYERVFGTPHRTDIASMCAGFHIPHRRVGVDELRSVLAESPTAGGI 534 Query 532 RVLEVKADRSSLRQLHAAIKAAL 554 V+EV DR LR +HAAI A L Sbjct 535 EVIEVATDRDRLRSVHAAIAARL 557 >gi|54027107|ref|YP_121349.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Nocardia farcinica IFM 10152] gi|81602385|sp|Q5YPA6.1|MEND_NOCFA RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|54018615|dbj|BAD59985.1| putative 2-oxoglutarate decarboxylase/2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate synthase [Nocardia farcinica IFM 10152] Length=545 Score = 671 bits (1731), Expect = 0.0, Method: Compositional matrix adjust. Identities = 380/557 (69%), Positives = 429/557 (78%), Gaps = 17/557 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARVVVDEL+RGGVRDVVLCPGSRNAPLAFALQ AD +GR+RLH+RIDERTAG+ Sbjct 1 MNPSTAQARVVVDELVRGGVRDVVLCPGSRNAPLAFALQAADAAGRLRLHMRIDERTAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAI AGAPV V MTSGTAVANLGPAV+EANYARVPLIVLSANRPYE+LGTGANQT+ Sbjct 61 LAIGLAISAGAPVPVVMTSGTAVANLGPAVLEANYARVPLIVLSANRPYEMLGTGANQTV 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSAL---NATWRSATCRVLAAATGARTANAGPVHF 177 EQLG FG+QVRA+ISLGLAE + N+ WRSA CRVLAAA G R+ NAGPVHF Sbjct 121 EQLGLFGSQVRATISLGLAEADGAGAGSYDQQNSVWRSAVCRVLAAARGTRSGNAGPVHF 180 Query 178 DIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVH 237 DIPLREPLVPD G P GR G PWT T T D PL+IDL+ DTVV+SGHGAG+ Sbjct 181 DIPLREPLVPDLAE-GEAEPAGRAGGAPWTATQYATLDVPLEIDLTPDTVVVSGHGAGLR 239 Query 238 PNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFA 297 P LA LPTVAEPTAP G LHPLALPLL P+Q I+ GRPTLHR VS LLAD V V+A Sbjct 240 PELAHLPTVAEPTAPMHGPA-LHPLALPLLTPRQAIITGRPTLHRQVSRLLADPAVTVYA 298 Query 298 LTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLH 357 LTTGPRWPDVSGN TGTRAVT+G PRP WL C ++ A VR +LA HP TGLH Sbjct 299 LTTGPRWPDVSGNVVGTGTRAVTSGGPRPEWLAHCRELDEKARQVVRAELAGHPKPTGLH 358 Query 358 VAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALA 417 VAA V ALR GDQL+LGASNPVRD AL G+RV SNRGVAGIDGTVSTA+GAALA Sbjct 359 VAAVVMDALREGDQLLLGASNPVRDAALVATPRPGVRVLSNRGVAGIDGTVSTAVGAALA 418 Query 418 YEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFEL 477 + P RTIALIGDLTF+HD++GLLIG EP P LTIVV+ND+GGGIFEL Sbjct 419 H------------PGRTIALIGDLTFLHDAAGLLIGRGEPRPADLTIVVANDDGGGIFEL 466 Query 478 LEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVK 537 LEQGDP+++ V R+FGTPH +D+ ALC AY + RQ++ EL L G+RVLEV Sbjct 467 LEQGDPQYAGVFERVFGTPHGMDLAALCAAYRIPHRQVDPAELAAELAGDAHGLRVLEVI 526 Query 538 ADRSSLRQLHAAIKAAL 554 +RSSLR+LHA ++A + Sbjct 527 TERSSLRELHATVRAKI 543 >gi|296138462|ref|YP_003645705.1| thiamine pyrophosphate TPP binding domain-containing protein [Tsukamurella paurometabola DSM 20162] gi|296026596|gb|ADG77366.1| thiamine pyrophosphate protein TPP binding domain protein [Tsukamurella paurometabola DSM 20162] Length=548 Score = 664 bits (1713), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/557 (68%), Positives = 424/557 (77%), Gaps = 28/557 (5%) Query 2 NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYL 61 NPST QARV+VDEL+RGGV D+VLCPGSRNAPLAFA+ AD G +RLHVRIDERTAG+L Sbjct 7 NPSTLQARVIVDELVRGGVTDIVLCPGSRNAPLAFAVHAADVRGDLRLHVRIDERTAGFL 66 Query 62 AIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTME 121 A+G+A PV V MTSGTAVANL PAV EANYARVPL+V+SANRPYELLG+GANQT+E Sbjct 67 AVGIAAATRRPVAVIMTSGTAVANLSPAVYEANYARVPLLVISANRPYELLGSGANQTVE 126 Query 122 QLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPL 181 Q G FGTQVRA +SLGLAE +R N+ WRSA CR LAAA GART NAGPV FDIPL Sbjct 127 QFGIFGTQVRACLSLGLAEPGLDR----NSQWRSAVCRALAAARGARTGNAGPVQFDIPL 182 Query 182 REPLVP-DPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 REPLVP DP P A GRP G PWT P T D PL IDLS DTVVISGHGAG +P L Sbjct 183 REPLVPDDPSPALA---QGRPDGGPWTVAPVATLDVPLPIDLSPDTVVISGHGAGANPAL 239 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT 300 A LPTVAEPTAP+ NPLHP ALPLLRP+Q I+ GRPTLHR VS LLAD V V+A+TT Sbjct 240 AHLPTVAEPTAPQP-KNPLHPWALPLLRPRQAIICGRPTLHREVSALLADPGVTVYAVTT 298 Query 301 GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA 360 GPRWPDVSGN ATGTR V G P AWL RCA +R A AAV + LAA P+ TGLHVA Sbjct 299 GPRWPDVSGNVAATGTRVVPVGDPDEAWLARCAEADRLARAAVTDGLAAEPV-TGLHVAR 357 Query 361 AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG 420 AV ALRPGDQLV+GASNPVRDVALAG G+ V SNRGVAGIDGTVSTA+GAALA Sbjct 358 AVCAALRPGDQLVVGASNPVRDVALAGDVPPGVTVLSNRGVAGIDGTVSTAVGAALA--- 414 Query 421 AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ 480 +PD+ RTIAL+GDLTFVHD+SGLLIGP EP PR LTIVV+NDNGGGIF LLEQ Sbjct 415 ------APDT--RTIALMGDLTFVHDASGLLIGPEEPRPRDLTIVVANDNGGGIFNLLEQ 466 Query 481 GDPRFS-----DVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLE 535 G+ R+S ++R+FGTPH D+ +LC AY ++ R EVD+L +P GMRV+E Sbjct 467 GEERYSGAEYDGAAARVFGTPHGTDLASLCAAYGIDYRLAEVDDLAAIAAEP--GMRVVE 524 Query 536 VKADRSSLRQLHAAIKA 552 V+ RS LR LHA ++A Sbjct 525 VRTQRSGLRALHAGMRA 541 >gi|296393035|ref|YP_003657919.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase [Segniliparus rotundus DSM 44985] gi|296180182|gb|ADG97088.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase [Segniliparus rotundus DSM 44985] Length=552 Score = 646 bits (1667), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/561 (63%), Positives = 406/561 (73%), Gaps = 27/561 (4%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDE +RGGVR+ VLCPGSRNAPL+FAL A+R+GR+RLHVRIDER+AG+ Sbjct 1 MNPSTLQARVLVDEFLRGGVREAVLCPGSRNAPLSFALHAAERAGRVRLHVRIDERSAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA +GAPV V MTSGTAVANLGPAV EANYARVPLIVLSANRPYE+LG+G NQ + Sbjct 61 LAVGLAAASGAPVIVVMTSGTAVANLGPAVCEANYARVPLIVLSANRPYEVLGSGVNQVI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FG+QVR ++S GLAE A S WR+ R L+AATG RT NAGPV FD+P Sbjct 121 EQLGLFGSQVREAVSAGLAEQAATSGS----QWRARVVRALSAATGTRTGNAGPVQFDVP 176 Query 181 LREPLVP-----DPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAG 235 REPLVP D E GRP G PWT P F+ P IDLSV TVV+SGHGAG Sbjct 177 FREPLVPQAPEDDLESHCGGAFAGRPGGGPWTQIPQGGFEIPTPIDLSVPTVVVSGHGAG 236 Query 236 VHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPV 295 HP LAALPTVAEPTAP NPLHP A+P + +Q ++ GRPTLHR V+ LLAD V V Sbjct 237 SHPELAALPTVAEPTAPVPA-NPLHPFAVPHVGAEQAVICGRPTLHRQVASLLADPAVRV 295 Query 296 FALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTG 355 +ALTTGPRWPDV+GN TGTRAV G+P PAWL RCA + A+ +V L A TTG Sbjct 296 YALTTGPRWPDVAGNVAGTGTRAVPVGSPDPAWLQRCARAHAAALGSVGRGLDAEAATTG 355 Query 356 LHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAA 415 LHVA AV ALRPGDQLVLGASNPVRDVALAG G+ VRSNRGV+GIDG +S+A+G+A Sbjct 356 LHVARAVLAALRPGDQLVLGASNPVRDVALAGGVPAGVAVRSNRGVSGIDGVLSSAVGSA 415 Query 416 LAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIF 475 LA+EG RTIAL+GDLTF+HD SGL+IGP EP PRSL IVV+ND+GGGIF Sbjct 416 LAHEG------------RTIALLGDLTFLHDVSGLVIGPHEPKPRSLAIVVANDDGGGIF 463 Query 476 ELLEQGDPR-----FSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAG 530 ELLEQG P + D R+FGTPH D ALC V + +DEL L G Sbjct 464 ELLEQGGPEYRAEAYGDAYERLFGTPHGKDFSALCAGLGVAHVRAALDELPAALGAEAEG 523 Query 531 MRVLEVKADRSSLRQLHAAIK 551 +RV+EV+ DR +LR LH A++ Sbjct 524 LRVVEVRTDRGALRDLHRAMR 544 >gi|262201085|ref|YP_003272293.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene -1-carboxylic-acidsynthase [Gordonia bronchialis DSM 43247] gi|262084432|gb|ACY20400.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene -1-carboxylic-acidsynthase [Gordonia bronchialis DSM 43247] Length=555 Score = 645 bits (1663), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/564 (64%), Positives = 414/564 (74%), Gaps = 26/564 (4%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDE+IRGGV + VLCPGSRNAPLAFAL AD +GR+RLHVRIDER+AGY Sbjct 1 MNPSTLQARVIVDEMIRGGVAEAVLCPGSRNAPLAFALHAADSAGRLRLHVRIDERSAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA+ +G PV + MTSGTAVAN+ PAV EANYARVPL+V+SANRPYELLG+GANQT+ Sbjct 61 LALGLAVASGQPVPIVMTSGTAVANMSPAVFEANYARVPLVVVSANRPYELLGSGANQTV 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQ G FGTQVRA+ISLGLAE + N+ WRSA RVLAAA GART NAGPV FDIP Sbjct 121 EQFGIFGTQVRAAISLGLAEQDLD----TNSQWRSAVGRVLAAARGARTGNAGPVQFDIP 176 Query 181 LREPLVPDPEPLGAV---TPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVH 237 LREPLVPDP+ T GRP G PWT P D PL IDLS+DTVV+SGHG+GVH Sbjct 177 LREPLVPDPDVWPDDDLGTFAGRPGGLPWTQAPVGKLDVPLPIDLSLDTVVVSGHGSGVH 236 Query 238 PNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFA 297 P LA +PTVAEPTAP + LHPLAL +RPQQ I+ GRPTLHR VS LLAD V V+A Sbjct 237 PQLAGIPTVAEPTAPHP-QSALHPLALERVRPQQAIICGRPTLHRGVSRLLADPSVRVYA 295 Query 298 LTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLH 357 LTTGPRWPDVSGN ATGTRA TG PR WL CAA+ + + AV +L A TGLH Sbjct 296 LTTGPRWPDVSGNVFATGTRAEPTGEPREEWLKECAAVQQRVLGAVDAELDAPGPDTGLH 355 Query 358 VAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALA 417 VA AVS A+ G+QLV+GASNP+RDVALAG G+RV SNRGVAGIDGT STAIGAALA Sbjct 356 VARAVSAAMLAGEQLVVGASNPIRDVALAGRVGDGVRVLSNRGVAGIDGTNSTAIGAALA 415 Query 418 YEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFEL 477 S RT+AL+GDLTF+HD++GL+IGP EP P SL IVV+ND+GGGIF L Sbjct 416 -----------GSSGRTVALMGDLTFLHDATGLVIGPGEPRPASLRIVVANDDGGGIFGL 464 Query 478 LEQGDPRFSD-----VSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQP--GAG 530 LEQGDPRF+ R+FGTPH D+ ALC +H+ R++ EL L QP G Sbjct 465 LEQGDPRFNQGPYAGSYERVFGTPHRTDLAALCAGFHLPHRRVGTAELSTVLAQPPVAGG 524 Query 531 MRVLEVKADRSSLRQLHAAIKAAL 554 + V+EV DR LR +HA I L Sbjct 525 IEVIEVVTDRERLRTVHARIAERL 548 >gi|326383006|ref|ZP_08204695.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Gordonia neofelifaecis NRRL B-59395] gi|326198142|gb|EGD55327.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Gordonia neofelifaecis NRRL B-59395] Length=563 Score = 642 bits (1656), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/569 (63%), Positives = 414/569 (73%), Gaps = 31/569 (5%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDELIRGGV + VLCPGSRNAPLAFAL AD GR+RLHVRIDER+AGY Sbjct 1 MNPSTLQARVIVDELIRGGVTEAVLCPGSRNAPLAFALHAADAQGRLRLHVRIDERSAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA+ +G PV + MTSGTAVAN+GPAV EANYARVPL+V+SANRPYELLG+GANQT+ Sbjct 61 LALGLAVASGRPVPIVMTSGTAVANMGPAVFEANYARVPLVVISANRPYELLGSGANQTI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQ G FGTQVRA+ISLGLAE+ + N+ WRSA RVLAAA GART NAGPV FDIP Sbjct 121 EQFGMFGTQVRAAISLGLAEEELD----TNSQWRSAVGRVLAAARGARTGNAGPVQFDIP 176 Query 181 LREPLVPD----PEPLGAVTPPGRPAGK----PWTYTPPVTFDQPLDIDLSVDTVVISGH 232 LREPLVPD P+ AV GR G+ PWT P D PL+IDLS DTVV+SGH Sbjct 177 LREPLVPDAADLPDADLAVAAGGRFVGRHGDAPWTQAPVGRLDIPLEIDLSRDTVVVSGH 236 Query 233 GAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAE 292 GAG+HP LAALPTVAEPTAP NPLHPLAL L+P Q I+ GRPTLHR VS LLAD Sbjct 237 GAGIHPELAALPTVAEPTAPHVA-NPLHPLALGRLKPTQAIICGRPTLHRSVSRLLADPS 295 Query 293 VPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPL 352 V VFALTTGPRWPDVSGN ATGTRAV TG P+ WLD A M+ AV +L+ Sbjct 296 VEVFALTTGPRWPDVSGNVFATGTRAVATGDPQQRWLDEAARMHASVETAVAAELSDSHE 355 Query 353 TTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAI 412 TTGLHVA V+ A+ PGD LV+GASNP+RD+ALAG G++V SNRGVAGIDGT +TAI Sbjct 356 TTGLHVARTVAAAMAPGDTLVVGASNPIRDIALAGTVADGVKVMSNRGVAGIDGTNATAI 415 Query 413 GAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGG 472 GAALA RT+AL+GDLTF+HD++GL+IGP EP P L IVV+ND+GG Sbjct 416 GAALARGDG-----------RTVALMGDLTFIHDATGLIIGPDEPRPTDLRIVVANDDGG 464 Query 473 GIFELLEQGDPRFS-----DVSSRIFGTPHDVDVGALCRAYHVESRQIE--VDELGPTLD 525 GIF LLEQGDPRF+ V RIFGTPH D+ A+C +++ R+++ Sbjct 465 GIFGLLEQGDPRFARDAYLGVYDRIFGTPHRTDLAAMCAGFNIGHRRVDLAGLPAALAGP 524 Query 526 QPGAGMRVLEVKADRSSLRQLHAAIKAAL 554 P G+ V+EV+ +R LR+LH I A L Sbjct 525 APAGGVEVVEVRTNRDGLRELHRRIGARL 553 >gi|298524043|ref|ZP_07011452.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|298493837|gb|EFI29131.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] Length=283 Score = 553 bits (1426), Expect = 2e-155, Method: Compositional matrix adjust. Identities = 280/283 (99%), Positives = 281/283 (99%), Gaps = 0/283 (0%) Query 272 VIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDR 331 +IMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGA RPAWLDR Sbjct 1 MIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAARPAWLDR 60 Query 332 CAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTR 391 CAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTR Sbjct 61 CAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTR 120 Query 392 GIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLL 451 GI VRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLL Sbjct 121 GIPVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLL 180 Query 452 IGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVE 511 IGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVE Sbjct 181 IGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVE 240 Query 512 SRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL 554 SRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL Sbjct 241 SRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL 283 >gi|254777021|ref|ZP_05218537.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Mycobacterium avium subsp. avium ATCC 25291] Length=287 Score = 495 bits (1275), Expect = 8e-138, Method: Compositional matrix adjust. Identities = 263/288 (92%), Positives = 272/288 (95%), Gaps = 1/288 (0%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFAL DADR+GRIRLHVRIDERTAGY Sbjct 1 MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALADADRAGRIRLHVRIDERTAGY 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LAIGLAI AGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM Sbjct 61 LAIGLAIAAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLGYFGTQVRA+ISLGLAEDAPER ALNATWRSATCRVLAAATG+RTANAGPV FDIP Sbjct 121 EQLGYFGTQVRAAISLGLAEDAPERLDALNATWRSATCRVLAAATGSRTANAGPVQFDIP 180 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL 240 LREPLVPDPEP GA TP GRP G+PWTYTPPV+FDQPLDIDLS DTVVI+GHGAG HPNL Sbjct 181 LREPLVPDPEPHGAPTPAGRPGGRPWTYTPPVSFDQPLDIDLSPDTVVIAGHGAGTHPNL 240 Query 241 AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLL 288 A LPTVAEPTAP + DNPLHPLAL LLRP+QVIMLGRPTLHRPVS LL Sbjct 241 AQLPTVAEPTAP-APDNPLHPLALRLLRPKQVIMLGRPTLHRPVSALL 287 >gi|317506081|ref|ZP_07963908.1| menD protein [Segniliparus rugosus ATCC BAA-974] gi|316255625|gb|EFV14868.1| menD protein [Segniliparus rugosus ATCC BAA-974] Length=325 Score = 411 bits (1057), Expect = 1e-112, Method: Compositional matrix adjust. Identities = 216/329 (66%), Positives = 250/329 (76%), Gaps = 10/329 (3%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDE +RGGVRD VLCPGSRNAPL+FAL +A+R+GR+RLHVRIDER+AG+ Sbjct 1 MNPSTLQARVLVDEFLRGGVRDAVLCPGSRNAPLSFALHEAERAGRVRLHVRIDERSAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA +GAPV V MTSGTAVANLGPAV EANYARVPLIVLSAN+PY++LG+G NQ + Sbjct 61 LAVGLAAASGAPVIVVMTSGTAVANLGPAVCEANYARVPLIVLSANQPYDVLGSGVNQVI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 EQLG FGTQVR S+S G A+ + S WR+ R L+AATGAR+ NAGPV FD+P Sbjct 121 EQLGLFGTQVRESVSAGQADLSARSGS----QWRARVVRALSAATGARSGNAGPVQFDVP 176 Query 181 LREPLVP-----DPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAG 235 REPLVP D E GR G PWT P F+ P++IDLSVDTVV+SGHGAG Sbjct 177 FREPLVPEVEAEDLEGYQGGAFAGRADGGPWTRIPEGGFEIPVEIDLSVDTVVVSGHGAG 236 Query 236 VHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPV 295 HP LAALPTVAEPTAP NPLHP A+P + +Q I+ GRPTLHR VS LLAD V V Sbjct 237 SHPELAALPTVAEPTAPVP-QNPLHPFAVPHVGAKQAIICGRPTLHRQVSALLADPNVRV 295 Query 296 FALTTGPRWPDVSGNSQATGTRAVTTGAP 324 +ALTTGPRWPDV+GN AT TR V G P Sbjct 296 YALTTGPRWPDVAGNVAATSTRVVPVGQP 324 >gi|331699329|ref|YP_004335568.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Pseudonocardia dioxanivorans CB1190] gi|326954018|gb|AEA27715.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Pseudonocardia dioxanivorans CB1190] Length=558 Score = 400 bits (1028), Expect = 3e-109, Method: Compositional matrix adjust. Identities = 283/564 (51%), Positives = 348/564 (62%), Gaps = 43/564 (7%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPST QARV+VDEL+R GV DVVLCPGSRNAP A AL DAD +GR+RLHVRIDERTA + Sbjct 17 VNPSTAQARVIVDELVRCGVGDVVLCPGSRNAPFAIALHDADAAGRLRLHVRIDERTAAF 76 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA+ +G PV V TSGTAVANL PAV+EA+YA VPL+ L+A+RP EL+GTGA+QT+ Sbjct 77 LALGLALRSGRPVPVCTTSGTAVANLHPAVLEASYAGVPLVALTADRPPELVGTGASQTV 136 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Q G FG VR + L +A + WR+A A A GPVH D+P Sbjct 137 VQPGIFGDAVRHAAVLAVARS----EAGQQGRWRAAV----DRALAAALREPGPVHLDVP 188 Query 181 LREPLVPD-----PEPLGAVTPPGRPAGKPWTYTPP--VTFDQPLDIDLSVDTVVISGHG 233 EPLVPD P+PL GR G+PWT P +PL +D + TVV+ G G Sbjct 189 FAEPLVPDDDTSWPDPLD-----GRAGGRPWTAVAPGMPAASEPLPLDPAAPTVVVVGPG 243 Query 234 AGVHPNLAALPTVAEPTAPRSG----DNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLA 289 A +LA LP VAEP++ G P L P LRP QV++ GRPTLHRPV LLA Sbjct 244 APAGLDLAGLPVVAEPSSGYWGAGLRAGPWL-LGDPSLRPAQVVVAGRPTLHRPVQRLLA 302 Query 290 DAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAA 349 D V V A+ G W DV+ +A G+ + P WL R A +R A + + A Sbjct 303 DPAVAVHAIGDGAPWTDVAATVRAVGS--LPAMRPDAGWLARWQAADR-AASVALDAALA 359 Query 350 HPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVS 409 TGL +A A++ AL G LVLG+SNPVRD+ALAG G+ V SNRGVAGIDGTVS Sbjct 360 DDAPTGLRLAHALAAALPDGAALVLGSSNPVRDMALAGAPRAGLTVVSNRGVAGIDGTVS 419 Query 410 TAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSND 469 TA G ALA++G T AL+GDLT +HD++GL++GP EP P LT VV ND Sbjct 420 TATGVALAHDGP------------TFALLGDLTLLHDTTGLVLGPDEPAP-DLTFVVLND 466 Query 470 NGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQI-EVDELGPTLDQPG 528 GGGIF LLEQG P + R+FGTPH VDV ALC A V + + +L L P Sbjct 467 RGGGIFSLLEQGAPAHAASFERVFGTPHTVDVAALCAAVGVAHTAVDDPAKLAEVLGVP- 525 Query 529 AGMRVLEVKADRSSLRQLHAAIKA 552 AG ++EV+A+R LR HA ++A Sbjct 526 AGRTLVEVRAERGDLRDGHARLRA 549 >gi|256380685|ref|YP_003104345.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylic acid synthase/2-oxoglutarate decarboxylase [Actinosynnema mirum DSM 43827] gi|255924988|gb|ACU40499.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylic acid synthase/2-oxoglutarate decarboxylase [Actinosynnema mirum DSM 43827] Length=544 Score = 400 bits (1027), Expect = 4e-109, Method: Compositional matrix adjust. Identities = 280/582 (49%), Positives = 347/582 (60%), Gaps = 71/582 (12%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDEL+R GVR VVL PGSRNAPL+FAL DA +GR+ LHVRIDER+AG+ Sbjct 1 MNPSTAQARVLVDELVRNGVRHVVLSPGSRNAPLSFALHDAAVAGRLELHVRIDERSAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+GLA+ G+PV V TSGTAVANL PAV+EA ++ VPLI L+A+RP EL GA+QT+ Sbjct 61 LALGLALD-GSPVAVTCTSGTAVANLHPAVLEAAHSGVPLIALTADRPVELHRAGASQTV 119 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Q G G + ++ L +A ER + NA WRS CR +AAA + GPVH ++P Sbjct 120 RQDGALGLE---TLHLPVA----ERRAGQNALWRSLVCRAVAAAR-----DGGPVHLNVP 167 Query 181 LREPLVPDP----EPLGAVTPPGRPAGKPWTYTPPVTFDQPLDID-LSVDTVVISGHGAG 235 REPL P+ EPL GRP +PWT T D P D L T+VI G Sbjct 168 FREPLTPEGGDWVEPL-----EGRPFDQPWTRTASRRVDAPHPADHLGPRTLVILGDAGA 222 Query 236 VH----PNLAA---LPTVAEPTAPRSGDNPLH--------PLALPLLRPQQVIMLGRPTL 280 +LAA P +AEPTA SG H PLA LRP V++LGR TL Sbjct 223 TDGEAVCDLAARAGWPVIAEPTA--SGRTVQHGSLLLNAGPLA-ERLRPDAVVVLGRATL 279 Query 281 HRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAP-----RPAWLDRCAAM 335 R V LL V V +T WPD + + T + AP WL Sbjct 280 SRGVQALLGSTSV-VHVVTASADWPD----PKFSATHVSASLAPGAHEVDDDWLTAWRHA 334 Query 336 NRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRV 395 ++ A AV LA P TG+HVA AV AL PG L LG+SNPVRDV A + V Sbjct 335 DKAAGEAVAALLADEPWPTGMHVARAVVEALPPGSALFLGSSNPVRDVDFAAPPRPDVVV 394 Query 396 RSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPT 455 R+NRGVAGIDG+VSTAIG AL + P T AL+GDLTF+HDS+GLLIGP Sbjct 395 RANRGVAGIDGSVSTAIGLAL------------ECGP-TTALMGDLTFLHDSNGLLIGPH 441 Query 456 EPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAY---HVES 512 E P LT+VV ND+GGGIF LLEQG P +D R+FGTPH D+ ALC A+ HV + Sbjct 442 ERRP-DLTVVVLNDDGGGIFALLEQGAPEHADSFERVFGTPHGTDLAALCAAHGVPHVLA 500 Query 513 RQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL 554 E EL + +P +G+RV+EV+A+R+ LR+LH +K A+ Sbjct 501 GSAE--ELRAEITRP-SGIRVVEVRAERAGLRELHKRVKTAV 539 >gi|257054387|ref|YP_003132219.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Saccharomonospora viridis DSM 43017] gi|256584259|gb|ACU95392.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Saccharomonospora viridis DSM 43017] Length=559 Score = 395 bits (1016), Expect = 9e-108, Method: Compositional matrix adjust. Identities = 265/584 (46%), Positives = 327/584 (56%), Gaps = 62/584 (10%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDEL+R V VVL PGSRNAPL+FAL DA +GR+ LHVRIDER+A + Sbjct 1 MNPSTAQARVLVDELVRNTVSHVVLSPGSRNAPLSFALHDAAMAGRLTLHVRIDERSAAF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+G+A G PV + TSGTA AN PAV+EA+ A VPLIVL+A+RP EL GANQ + Sbjct 61 LALGIAARTGRPVALVCTSGTAAANFHPAVLEADRAGVPLIVLTADRPPELRAAGANQVI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 +Q G +G VR L +AE P + NA WRS CR AA G GPVH +IP Sbjct 121 DQRGLYGPAVRYFDELAVAERRPGQ----NAYWRSQICRAWNAAYG--EWRCGPVHLNIP 174 Query 181 LREPLVPD--------PEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISG- 231 REPLVPD PEPL GRP G WT P D +VV S Sbjct 175 FREPLVPDGKDDPDDWPEPLD-----GRPQGARWTELP--------DFGALPSSVVPSAR 221 Query 232 HG-----------AGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLL---------RPQQ 271 HG AG L P V+E G + LL +P+Q Sbjct 222 HGLVVACDAGVRAAGEWAELHGWPVVSETGGLGLGGTTAIAGGVWLLGVEEFLAEHKPEQ 281 Query 272 VIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAP-RPAWLD 330 V+ +GRPT+ R V LL+D ++ V + WP + N + G P P WL Sbjct 282 VLCIGRPTVFRQVQRLLSDPDIEVLLVRPDSDWPAPAHNVRQVGQWFDEPAKPADPEWLS 341 Query 331 RCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDT 390 R + A+AAVRE LA P TGL VA+ + L P LV+G+SNP RDVAL G Sbjct 342 RWREADAAAVAAVRETLAEQPWPTGLSVASELVENLPPDSLLVVGSSNPTRDVALVGGRR 401 Query 391 RGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGL 450 + V NRGVAGIDGT+STA+GAAL + G AL+GDLTF+HD +GL Sbjct 402 PDVLVHRNRGVAGIDGTISTAVGAALVHSGP------------AYALVGDLTFLHDVNGL 449 Query 451 LIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHV 510 L GPTE P LTIVV ND+GGGIF LLEQG+ + S R+FGTPH D+ ALC Y V Sbjct 450 LAGPTESRP-DLTIVVLNDDGGGIFSLLEQGEEQHSARFERVFGTPHGADLSALCAGYGV 508 Query 511 ESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL 554 E+ +P G+RV+EV+ DRS R+LHA ++ A+ Sbjct 509 PYTLASSREVLREALRPAPGLRVVEVRVDRSRHRELHALLRGAV 552 >gi|213964900|ref|ZP_03393099.1| menaquinone biosynthesis protein MenD [Corynebacterium amycolatum SK46] gi|213952436|gb|EEB63819.1| menaquinone biosynthesis protein MenD [Corynebacterium amycolatum SK46] Length=633 Score = 394 bits (1013), Expect = 2e-107, Method: Compositional matrix adjust. Identities = 258/582 (45%), Positives = 334/582 (58%), Gaps = 59/582 (10%) Query 8 ARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAI 67 A ++VDEL+R G+ D V+CPGSR+APLA AL A + ++RLHVRIDER+A +LA+GLA Sbjct 54 AGLIVDELLRLGMVDAVVCPGSRSAPLARALVQAADAAKVRLHVRIDERSAAFLALGLAS 113 Query 68 GAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFG 127 V TSGTAVANL PA+VEA + +PL+ L+A+RP GTGANQT+ Q F Sbjct 114 RTRKVTPVITTSGTAVANLVPAMVEATASGIPLLALTADRPAHYRGTGANQTIVQDRLFA 173 Query 128 TQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVP 187 + + L AP T A A R+ RV+AA +G H ++ EPLVP Sbjct 174 DA--SVVEFDLDGTAP-VTKATAAQIRARIDRVVAAMA------SGAGHLNVRFVEPLVP 224 Query 188 DPEPLGAVTPPGRPAGKPWT-----------------------YTPPVTFDQPLDIDLSV 224 D + + + P GR G PWT T P ID+S Sbjct 225 DDDSVADI-PEGRADGGPWTTIAPTNSNNVGAAAIAAHSANSATTSPANTASTATIDISR 283 Query 225 DTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLA---LPLLRPQQVIMLGRPTLH 281 T+VI+G A P L LPT+AEP A + +P+HPLA + P+Q++++GRPTLH Sbjct 284 RTLVIAGSNAPHLPELEDLPTIAEPNA-YAPAHPVHPLAAGTFAQIPPEQIVLVGRPTLH 342 Query 282 RPVSVLLADAEVPVFALTT------GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAM 335 R +S LLA+ ++ + ++ G +PDV+ N++A T G P W C A Sbjct 343 RGISKLLANPDIELTVVSDAENHGFGVEFPDVTANARAVVKHVQTVGEQDPQWTKICEAA 402 Query 336 NRHAIAAVREQL-----AAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDT 390 + A+ +VRE L A PL TG HVAAA++ +LR GD +VLGASNPVRD + GL Sbjct 403 SELAVKSVRETLTDSIEAEEPL-TGFHVAAALTDSLRTGDNVVLGASNPVRDASYTGLPF 461 Query 391 RGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGL 450 G+ + RG AGIDGTV+TAIG ALA + H PPRTIAL+GDLTF HDS+ L Sbjct 462 PGVNTYAGRGAAGIDGTVATAIGIALASDREH---ADEIRPPRTIALMGDLTFQHDSAAL 518 Query 451 LIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHV 510 IGP EP P +LTIVV+ND GGGIFE LE G P RIFGTP DVD +C+AY V Sbjct 519 AIGPLEPRPENLTIVVANDAGGGIFETLEAGSPALRGSFERIFGTPQDVDFEGICQAYGV 578 Query 511 ESRQIEVDELGPTL-----DQPGAGMRVLEVKADRSSLRQLH 547 E + VD L L D G+RV+EV R++ RQLH Sbjct 579 E--HVHVDRLPDLLAQLHPDTDVDGIRVIEVATTRATRRQLH 618 >gi|302523865|ref|ZP_07276207.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase [Streptomyces sp. AA4] gi|302432760|gb|EFL04576.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase [Streptomyces sp. AA4] Length=558 Score = 390 bits (1003), Expect = 3e-106, Method: Compositional matrix adjust. Identities = 260/570 (46%), Positives = 317/570 (56%), Gaps = 35/570 (6%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDEL+R V VVLCPGSRNAPL+ AL DA SGR++LHVRIDER A + Sbjct 1 MNPSTAQARVIVDELVRNTVSHVVLCPGSRNAPLSIALYDAAASGRLQLHVRIDERGAAF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+G+A G P V TSGTA AN PAV+EA+ A VPLIVL+A+RP EL GA+Q + Sbjct 61 LALGIAARTGRPAAVVCTSGTAAANFHPAVLEADRAGVPLIVLTADRPPELRSAGASQVI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 Q +G VR L +AE R + N+ WRS CR AA G GPVH +IP Sbjct 121 NQYELYGDAVRYFDELAVAE----RRAGQNSYWRSQICRAWNAAYG--EWRCGPVHLNIP 174 Query 181 LREPLVPDPEPLGAVTP--PGRPAGKPWTYTPPV----TFDQPLDIDLSVDTVVISGHGA 234 REPLVPD + G GRP G+ WT P +F P V A Sbjct 175 FREPLVPDLDDDGEWYESLEGRPDGERWTELPDFGALPSFVVPSARHGLVIACDTGAQAA 234 Query 235 GVHPNLAALPTVAE--------PTAPRSGDNPLH-PLALPLLRPQQVIMLGRPTLHRPVS 285 P V+E TA SG L + RP+QV+ LGRPT+ R V Sbjct 235 SEWAEQHGWPVVSETGGLGLSGATAMSSGAWLLGVEEFISRHRPEQVLCLGRPTVFRQVQ 294 Query 286 VLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAP-RPAWLDRCAAMNRHAIAAVR 344 +L+D EV V + WP + N + G P P WL + A AV Sbjct 295 KVLSDPEVEVLLVRPDSDWPAPAHNVRQVGQWFAEPTKPADPEWLASWQRADAAASQAVA 354 Query 345 EQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGI 404 LAA P +G+ VA + AL G LV+G+SNP RDVALAG + V NRGVAGI Sbjct 355 TALAAEPWPSGVRVATELVDALPEGALLVVGSSNPTRDVALAGRLRPDVLVHRNRGVAGI 414 Query 405 DGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTI 464 DGTVSTAIGAA + + AL+GDLTF+HD+SGLL GP E +P LTI Sbjct 415 DGTVSTAIGAATVHRAP------------SYALLGDLTFLHDASGLLTGPAEQLP-DLTI 461 Query 465 VVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTL 524 VV ND+GGGIF LLEQG P S R+FGTPH D+GALC Y V E E Sbjct 462 VVLNDDGGGIFSLLEQGAPEHSASFERVFGTPHGADLGALCAGYRVPHVVAETVEEFRAA 521 Query 525 DQPGAGMRVLEVKADRSSLRQLHAAIKAAL 554 +P G+RV+EV+ DR+ R LHA +K+A+ Sbjct 522 LRPAPGLRVVEVRVDRAQHRNLHARLKSAV 551 >gi|134103340|ref|YP_001109001.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxy late synthase/2-oxoglutarate decarboxylase [Saccharopolyspora erythraea NRRL 2338] gi|291004441|ref|ZP_06562414.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Saccharopolyspora erythraea NRRL 2338] gi|193806103|sp|A4FPV1.1|MEND_SACEN RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; AltName: Full=Menaquinone biosynthesis protein menD gi|133915963|emb|CAM06076.1| 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase [Saccharopolyspora erythraea NRRL 2338] Length=556 Score = 389 bits (998), Expect = 8e-106, Method: Compositional matrix adjust. Identities = 262/576 (46%), Positives = 331/576 (58%), Gaps = 44/576 (7%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QA V+VDEL+R GVR VVL PGSRNAPL+FAL DA +GR+ LHVRIDER+AG+ Sbjct 1 MNPSTAQAEVLVDELVRNGVRQVVLAPGSRNAPLSFALHDAAEAGRLDLHVRIDERSAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+G+A PV V TSGTA NL PAV EA +A +PLIVL+A+RP EL GANQT+ Sbjct 61 LALGIATRTRRPVVVVCTSGTAATNLHPAVSEACHAGIPLIVLTADRPPELRAAGANQTI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 +Q +GT+VR L +AE+ P + NA WR+ CR AA+ A T GPVH ++P Sbjct 121 DQYRLYGTEVRLFDELAVAENRPGQ----NAYWRTQVCR--AASMAAGTTWGGPVHLNLP 174 Query 181 LREPLVPDPEPLGAVTPPGRPAGKPWTY-----TPPVTFDQP-------LDIDLSVDTVV 228 REPLVP + GR G+ WT + P T + L D D+ Sbjct 175 FREPLVPSGDRDWCEPLDGRADGQRWTEVSGNESAPSTLSKVRSRRGLVLVADGGADSAS 234 Query 229 ISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLL----RPQQVIMLGRPTLHRPV 284 G G P L+ V A + + L LP RP+QV+ +GR T+ R V Sbjct 235 AWGERYGW-PVLSETGGVGLSGAA-AISTGMWLLKLPGFMRDHRPEQVLCVGRNTVFRQV 292 Query 285 SVLLADAEVPVFALTTGPRWPDVSGN-SQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAV 343 LLAD+EV V G WP + N + T + G P WL ++ A AA+ Sbjct 293 QSLLADSEVEVLLAHGGSHWPTPAHNVREVAETFGASPGPADPDWLTGWQQADQKASAAL 352 Query 344 REQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAG 403 L G VA V AL G LVLG+SNP RDVALA + V NRGVAG Sbjct 353 HAALDLERWPNGPVVARDVVDALPAGSLLVLGSSNPTRDVALAANHRPDVVVHRNRGVAG 412 Query 404 IDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLT 463 IDGTVS AIG+ALA+ G + AL+GDLTF+HDS+GL++GP E P LT Sbjct 413 IDGTVSAAIGSALAHGGP------------SYALLGDLTFLHDSNGLMLGPQEQRP-DLT 459 Query 464 IVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQI-EVDELGP 522 IVV ND+GGGIF LLEQG P R+FGTPH D+G+LC A+ VE + + E G Sbjct 460 IVVLNDDGGGIFSLLEQGSPEHRGSFERVFGTPHGTDIGSLCAAHGVEHTVVRQRSEFGV 519 Query 523 TLDQPGAGMRVLEVKADRSSLR----QLHAAIKAAL 554 L + G+RV+EV+ADR+ LR +LHAA++ AL Sbjct 520 ALRRR-PGLRVVEVRADRAELRGVHERLHAAVRGAL 554 >gi|300782441|ref|YP_003762732.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase [Amycolatopsis mediterranei U32] gi|299791955|gb|ADJ42330.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase [Amycolatopsis mediterranei U32] Length=560 Score = 380 bits (977), Expect = 3e-103, Method: Compositional matrix adjust. Identities = 259/571 (46%), Positives = 319/571 (56%), Gaps = 43/571 (7%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 VNPST QARV+VDEL+R V VVLCPGSRNAPL+ AL DA +G++RLHVRIDER AG+ Sbjct 3 VNPSTAQARVIVDELVRNTVSHVVLCPGSRNAPLSIALYDAAAAGKLRLHVRIDERGAGF 62 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+G+A G PV V TSGTA AN PAV+EA+ A VPLIV++A+RP EL GA+Q + Sbjct 63 LALGIAARTGRPVAVLCTSGTAAANFHPAVLEADRAGVPLIVMTADRPPELRAAGASQVI 122 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 +Q +G VR L +AE R + N+ WRS CR AA G GPVH +IP Sbjct 123 DQHQLYGDAVRYFDELAVAE----RRAGQNSYWRSQICRAWNAAYG--EWRCGPVHLNIP 176 Query 181 LREPLVPDPEPLGAVTPP--GRPAGKPWTYTPPV----TFDQP---LDIDLSVDTVVISG 231 REPLVPD + G GR G WT P +F P + ++ DT V Sbjct 177 FREPLVPDLDDDGEWYESLDGRADGSRWTELPDFGALPSFVVPSARHGLVIACDTGV--- 233 Query 232 HGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLL---------RPQQVIMLGRPTLHR 282 A P V+E + LL +P+QV+ LGRPT+ R Sbjct 234 QAASEWAEQHGWPVVSETGGLGLSGGTAISSGVWLLAVEEFISRHKPEQVLCLGRPTVFR 293 Query 283 PVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAP-RPAWLDRCAAMNRHAIA 341 + +L+DAEV V + WP + N + G P P WL + A + Sbjct 294 QIQQVLSDAEVEVLLVRPDSDWPAPAHNVRQVGQWFDEPTKPADPEWLASWRRADAAAAS 353 Query 342 AVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGV 401 AV LA P +GL VA + AL P LV+G+SNP RDVALAG + V NRGV Sbjct 354 AVAATLADEPWPSGLRVATELVDALPPDSLLVVGSSNPTRDVALAGRLRPDVLVHRNRGV 413 Query 402 AGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRS 461 AGIDGTVSTAIGAA + G + AL+GDLTF+HD+SGLL GP E P Sbjct 414 AGIDGTVSTAIGAAYVHRGP------------SYALLGDLTFLHDASGLLTGPAEQRP-D 460 Query 462 LTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIE-VDEL 520 LTIVV ND+GGGIF LLEQG P S R+FGTPH D+GALC Y V E + E Sbjct 461 LTIVVLNDDGGGIFSLLEQGAPEHSASFERVFGTPHGADLGALCAGYRVPHVVAETLTEF 520 Query 521 GPTLDQPGAGMRVLEVKADRSSLRQLHAAIK 551 L P G+RV+EV+ DRS R LHA ++ Sbjct 521 QAAL-APAPGLRVVEVRVDRSRHRDLHARLR 550 >gi|340523810|gb|AEK39015.1| 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Amycolatopsis mediterranei S699] Length=558 Score = 380 bits (976), Expect = 3e-103, Method: Compositional matrix adjust. Identities = 258/571 (46%), Positives = 319/571 (56%), Gaps = 43/571 (7%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 +NPST QARV+VDEL+R V VVLCPGSRNAPL+ AL DA +G++RLHVRIDER AG+ Sbjct 1 MNPSTAQARVIVDELVRNTVSHVVLCPGSRNAPLSIALYDAAAAGKLRLHVRIDERGAGF 60 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+G+A G PV V TSGTA AN PAV+EA+ A VPLIV++A+RP EL GA+Q + Sbjct 61 LALGIAARTGRPVAVLCTSGTAAANFHPAVLEADRAGVPLIVMTADRPPELRAAGASQVI 120 Query 121 EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP 180 +Q +G VR L +AE R + N+ WRS CR AA G GPVH +IP Sbjct 121 DQHQLYGDAVRYFDELAVAE----RRAGQNSYWRSQICRAWNAAYG--EWRCGPVHLNIP 174 Query 181 LREPLVPDPEPLGAVTPP--GRPAGKPWTYTPPV----TFDQP---LDIDLSVDTVVISG 231 REPLVPD + G GR G WT P +F P + ++ DT V Sbjct 175 FREPLVPDLDDDGEWYESLDGRADGSRWTELPDFGALPSFVVPSARHGLVIACDTGV--- 231 Query 232 HGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLL---------RPQQVIMLGRPTLHR 282 A P V+E + LL +P+QV+ LGRPT+ R Sbjct 232 QAASEWAEQHGWPVVSETGGLGLSGGTAISSGVWLLAVEEFISRHKPEQVLCLGRPTVFR 291 Query 283 PVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAP-RPAWLDRCAAMNRHAIA 341 + +L+DAEV V + WP + N + G P P WL + A + Sbjct 292 QIQQVLSDAEVEVLLVRPDSDWPAPAHNVRQVGQWFDEPTKPADPEWLASWRRADAAAAS 351 Query 342 AVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGV 401 AV LA P +GL VA + AL P LV+G+SNP RDVALAG + V NRGV Sbjct 352 AVAATLADEPWPSGLRVATELVDALPPDSLLVVGSSNPTRDVALAGRLRPDVLVHRNRGV 411 Query 402 AGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRS 461 AGIDGTVSTAIGAA + G + AL+GDLTF+HD+SGLL GP E P Sbjct 412 AGIDGTVSTAIGAAYVHRGP------------SYALLGDLTFLHDASGLLTGPAEQRP-D 458 Query 462 LTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIE-VDEL 520 LTIVV ND+GGGIF LLEQG P S R+FGTPH D+GALC Y V E + E Sbjct 459 LTIVVLNDDGGGIFSLLEQGAPEHSASFERVFGTPHGADLGALCAGYRVPHVVAETLTEF 518 Query 521 GPTLDQPGAGMRVLEVKADRSSLRQLHAAIK 551 L P G+RV+EV+ DRS R LHA ++ Sbjct 519 QAAL-APAPGLRVVEVRVDRSRHRDLHARLR 548 >gi|336326472|ref|YP_004606438.1| 2-oxoglutarate decarboxylase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Corynebacterium resistens DSM 45100] gi|336102454|gb|AEI10274.1| 2-oxoglutarate decarboxylase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Corynebacterium resistens DSM 45100] Length=616 Score = 379 bits (973), Expect = 8e-103, Method: Compositional matrix adjust. Identities = 259/612 (43%), Positives = 348/612 (57%), Gaps = 72/612 (11%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 ++P+ A VVV+ELI GVR+ V+CPGSR+APLA A+ +A R GR+R+HVR DERT + Sbjct 10 ISPAMATALVVVEELIEAGVREAVVCPGSRSAPLAIAVAEASRVGRLRMHVRTDERTGAF 69 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 A+GLA + PV V MTSGTAVAN PA+VEA PLIV+SANRP ++GTGANQT+ Sbjct 70 FALGLAKYSRRPVPVIMTSGTAVANCLPAMVEATLTHAPLIVVSANRPLHMVGTGANQTI 129 Query 121 EQLGYFGTQVRASISLG-LAEDAPER--TSALNAT---WRSATCRVLAAATGARTANAGP 174 +Q+G FG+ + +L + E +R T L A + T R + AA TA G Sbjct 130 DQVGIFGSHSVCTRTLDQIGEACAQRGITEGLPADQVGYLQNTVREVIAAAMHPTAGGG- 188 Query 175 VHFDIPLREPLVP-DPEPLGAVTP---------PGRPA--GKPWTYTPPVTFDQPLDIDL 222 V D+PLREPLVP D +G P +PA G+P + +++DL Sbjct 189 VQLDVPLREPLVPKDSAVVGLAASEIQETLSRAPKKPAEPGRPSREIS----SEAVEVDL 244 Query 223 SVDTVVISGH------GAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLL--------- 267 + T+VI G G + LA +PT+AEP AP + + P+H A + Sbjct 245 AKRTLVIVGEVTDRAWGRQIMDQLADVPTMAEPIAPDAPEIPVHSGAAAMFTTDAVAHGE 304 Query 268 -----RPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVT-T 321 RP+Q++++GRPTLHRPV+ LLAD + V +T DVSG + A TRA+ T Sbjct 305 YSAVTRPEQIVVVGRPTLHRPVAKLLADPHIRVVVVTDTDTVTDVSGTAAAV-TRAIKLT 363 Query 322 GAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVR 381 G WL C A++ AVR+ L T +H AAV+ +LR GD +VLGAS VR Sbjct 364 GKADQQWLSVCRAISDMGADAVRQALEGSEDFTAIHAVAAVADSLRDGDAVVLGASTTVR 423 Query 382 DVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDS--PPRTIALIG 439 D + AGL G+ +NRG AGIDGT+STA+G A A+ GA E PD+ PRTIA++G Sbjct 424 DASRAGLPFAGVEALANRGAAGIDGTISTAVGVAFAH-GASE----PDAMRAPRTIAVMG 478 Query 440 DLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGD------PRFSDVSSRIF 493 DLTF+HD L +GP EP P +L I+V+NDNGGGIFE LE G P S++ RIF Sbjct 479 DLTFLHDVGALNVGPLEPQPDNLLIIVTNDNGGGIFETLEPGREELRTFPDGSEMFERIF 538 Query 494 GTPHDVDVGALCRAYHVESR--------------QIEVDELGPTLDQPGAGMRVLEVKAD 539 GTP D+G LC + V R E+ L T + +G+ V+E + Sbjct 539 GTPLQADIGKLCAGFGVSHRLATNPTELALAIEEHAELGYLSSTNESAESGIAVIEAQVS 598 Query 540 RSSLRQLHAAIK 551 R+ RQ+ AI+ Sbjct 599 RAGRRQIEKAIR 610 >gi|340795377|ref|YP_004760840.1| 2-oxoglutarate decarboxylase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Corynebacterium variabile DSM 44702] gi|340535287|gb|AEK37767.1| 2-oxoglutarate decarboxylase / 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Corynebacterium variabile DSM 44702] Length=664 Score = 369 bits (948), Expect = 6e-100, Method: Compositional matrix adjust. Identities = 266/614 (44%), Positives = 345/614 (57%), Gaps = 73/614 (11%) Query 1 VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY 60 + P+T A V+VDEL+R GVR+ V+CPGSR+A LA AL +ADR+ R+RLHVR DER+A + Sbjct 49 ITPATVVAAVIVDELVRAGVREAVVCPGSRSAALALALAEADRTHRLRLHVRTDERSASF 108 Query 61 LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM 120 LA+G+A +G PV V MTSGTAVAN PA+VEA + VPL++LSA+RP GTGANQT+ Sbjct 109 LALGMARRSGRPVPVLMTSGTAVANCLPAMVEATASGVPLLILSADRPVSYQGTGANQTI 168 Query 121 EQLGYFGTQVRASISLGLA-EDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDI 179 Q G FG S+SL A D P+ R T + G R AG V ++ Sbjct 169 AQSGIFGAHAVDSVSLAAALHDRPDHREVRTVVDRVVTSALDLFGGGVR---AGGVQLNV 225 Query 180 PLREPLVPD-------------PEPLGA---VTPPGRPAGKPWTYTP----PVTFDQP-- 217 EPLVP E G+ P R A +P P PV P Sbjct 226 HFVEPLVPGSTADVSLAARIAVEELTGSAENTDTPWRGAARPVNALPRSAAPVRAVLPES 285 Query 218 --LDIDLSVDTVVISGH------GAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPL--- 266 + +DLS T+VI G + LA +P +AEPTAP G P+HP A L Sbjct 286 PVVTVDLSKRTLVIVGDVRDRTWATRILDTLADVPAIAEPTAPSPG-TPVHPAAAGLFSG 344 Query 267 ----------------LRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGN 310 LRP+Q++++GRPTLHR VS LLAD +V V ALT PD++ Sbjct 345 TVSEDSAAAAAAQTAQLRPEQIVLVGRPTLHRSVSRLLADPQVRVVALTDRDVIPDLAHT 404 Query 311 SQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGD 370 + G TG WL C A + A+ +++ LA TGLHVAAAV+ ALR GD Sbjct 405 VREWGRGVALTGEHPAGWLTVCEAASGVAVDVMQDLLAGEDF-TGLHVAAAVTDALRDGD 463 Query 371 QLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPD- 429 LVLGAS+ VRD +LAGL G+ SNRG AGIDGTVSTA+G ALA+ H P+ Sbjct 464 ALVLGASSAVRDASLAGLPFEGVWAVSNRGAAGIDGTVSTAVGVALAHASEH-----PEL 518 Query 430 -SPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRF--- 485 PRT+AL+GDLT +HD +G +GP EP P +L +VVSND+GG IFE LE G+ Sbjct 519 VRAPRTVALMGDLTVLHDMNGFTVGPGEPRPDNLVVVVSNDDGGAIFETLEAGNRGLRTF 578 Query 486 ---SDVSSRIFGTPHDVDVGALCRAYHVESRQI-EVDELGPTLDQPGA----GMRVLEVK 537 +D R+FGTP VD+GALC + V R++ ++ EL LD+ G+ V+E Sbjct 579 DDGADAFDRVFGTPTGVDLGALCEGHGVAHRRVDDLQELIAALDEHAEGYTDGLLVIEAA 638 Query 538 ADRSSLRQLHAAIK 551 R+ LHAA++ Sbjct 639 VQRAPRAALHAALR 652 Lambda K H 0.318 0.135 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1231735515702 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40