BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0570 Length=692 Score E Sequences producing significant alignments: (Bits) Value gi|253797502|ref|YP_003030503.1| ribonucleoside-diphosphate redu... 1389 0.0 gi|15839968|ref|NP_335005.1| ribonucleoside-diphosphate reductas... 1386 0.0 gi|15607710|ref|NP_215084.1| ribonucleoside-diphosphate reductas... 1386 0.0 gi|298524058|ref|ZP_07011467.1| ribonucleoside-diphosphate reduc... 1385 0.0 gi|340625597|ref|YP_004744049.1| putative ribonucleoside-diphosp... 1382 0.0 gi|289446117|ref|ZP_06435861.1| ribonucleoside-diphosphate reduc... 1368 0.0 gi|31791752|ref|NP_854245.1| ribonucleoside-diphosphate reductas... 1262 0.0 gi|240169273|ref|ZP_04747932.1| ribonucleoside-diphosphate reduc... 1176 0.0 gi|120402409|ref|YP_952238.1| ribonucleoside-diphosphate reducta... 1102 0.0 gi|108798058|ref|YP_638255.1| ribonucleoside-diphosphate reducta... 1096 0.0 gi|296170901|ref|ZP_06852438.1| ribonucleoside-diphosphate reduc... 1021 0.0 gi|289749069|ref|ZP_06508447.1| ribonucleoside-diphosphate reduc... 1019 0.0 gi|298674718|ref|YP_003726468.1| ribonucleoside-diphosphate redu... 691 0.0 gi|330507668|ref|YP_004384096.1| ribonucleoside-diphosphate redu... 659 0.0 gi|116754614|ref|YP_843732.1| ribonucleoside-diphosphate reducta... 654 0.0 gi|254169166|ref|ZP_04876002.1| ribonucleoside-diphosphate reduc... 610 2e-172 gi|294496479|ref|YP_003542972.1| ribonucleoside-diphosphate redu... 608 1e-171 gi|11499254|ref|NP_070492.1| ribonucleotide-diphosphate reductas... 606 5e-171 gi|254169182|ref|ZP_04876017.1| ribonucleoside-diphosphate reduc... 603 3e-170 gi|291279559|ref|YP_003496394.1| ribonucleoside-diphosphate redu... 601 2e-169 gi|255514004|gb|EET90268.1| ribonucleoside-diphosphate reductase... 597 2e-168 gi|95930217|ref|ZP_01312955.1| ribonucleotide reductase large su... 595 6e-168 gi|333986799|ref|YP_004519406.1| ribonucleoside-diphosphate redu... 594 2e-167 gi|254168705|ref|ZP_04875547.1| ribonucleoside-diphosphate reduc... 591 1e-166 gi|289596835|ref|YP_003483531.1| ribonucleoside-diphosphate redu... 591 1e-166 gi|319789960|ref|YP_004151593.1| ribonucleoside-diphosphate redu... 590 3e-166 gi|327401108|ref|YP_004341947.1| ribonucleoside-diphosphate redu... 588 1e-165 gi|254168812|ref|ZP_04875653.1| ribonucleoside-diphosphate reduc... 588 1e-165 gi|220933052|ref|YP_002509960.1| ribonucleoside-diphosphate redu... 587 3e-165 gi|39996969|ref|NP_952920.1| ribonucleotide-diphosphate reductas... 586 6e-165 gi|78222511|ref|YP_384258.1| ribonucleotide-diphosphate reductas... 585 7e-165 gi|253701670|ref|YP_003022859.1| ribonucleotide-diphosphate redu... 585 1e-164 gi|197117589|ref|YP_002138016.1| ribonucleotide-diphosphate redu... 584 2e-164 gi|13540923|ref|NP_110611.1| ribonucleotide-diphosphate reductas... 584 2e-164 gi|322418582|ref|YP_004197805.1| ribonucleoside-diphosphate redu... 583 2e-164 gi|206889598|ref|YP_002247982.1| ribonucleoside-diphosphate redu... 583 3e-164 gi|189425377|ref|YP_001952554.1| ribonucleotide-diphosphate redu... 581 1e-163 gi|301058132|ref|ZP_07199184.1| ribonucleoside-diphosphate reduc... 581 2e-163 gi|222056106|ref|YP_002538468.1| ribonucleotide-diphosphate redu... 581 2e-163 gi|77919448|ref|YP_357263.1| ribonucleotide-diphosphate reductas... 579 7e-163 gi|302390649|ref|YP_003826470.1| ribonucleoside-diphosphate redu... 578 9e-163 gi|297568305|ref|YP_003689649.1| ribonucleoside-diphosphate redu... 576 4e-162 gi|300088374|ref|YP_003758896.1| ribonucleoside-diphosphate redu... 576 4e-162 gi|57234895|ref|YP_181092.1| ribonucleotide-diphosphate reductas... 575 6e-162 gi|118580911|ref|YP_902161.1| ribonucleotide-diphosphate reducta... 573 3e-161 gi|16082440|ref|NP_394926.1| ribonucleotide-diphosphate reductas... 573 5e-161 gi|148264309|ref|YP_001231015.1| ribonucleotide-diphosphate redu... 573 5e-161 gi|48478313|ref|YP_024019.1| ribonucleotide-diphosphate reductas... 572 6e-161 gi|220905096|ref|YP_002480408.1| ribonucleotide-diphosphate redu... 572 6e-161 gi|289579197|ref|YP_003477824.1| ribonucleoside-diphosphate redu... 571 2e-160 >gi|253797502|ref|YP_003030503.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis KZN 1435] gi|289552822|ref|ZP_06442032.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis KZN 605] gi|253319005|gb|ACT23608.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis KZN 1435] gi|289437454|gb|EFD19947.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis KZN 605] gi|328457287|gb|AEB02710.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis KZN 4207] Length=706 Score = 1389 bits (3596), Expect = 0.0, Method: Compositional matrix adjust. Identities = 692/692 (100%), Positives = 692/692 (100%), Gaps = 0/692 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 15 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 74 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 75 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 134 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 135 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 194 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 195 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 254 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 255 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 314 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 315 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 374 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 375 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 434 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 435 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 494 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 495 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 554 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA Sbjct 555 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 614 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR Sbjct 615 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 674 Query 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF Sbjct 675 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 706 >gi|15839968|ref|NP_335005.1| ribonucleoside-diphosphate reductase, alpha subunit, putative [Mycobacterium tuberculosis CDC1551] gi|13880109|gb|AAK44819.1| ribonucleoside-diphosphate reductase, alpha subunit, putative [Mycobacterium tuberculosis CDC1551] Length=735 Score = 1386 bits (3587), Expect = 0.0, Method: Compositional matrix adjust. Identities = 691/692 (99%), Positives = 691/692 (99%), Gaps = 0/692 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 44 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 103 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 104 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 163 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 164 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 223 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 224 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 283 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 284 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 343 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 344 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 403 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 404 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 463 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 464 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 523 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 524 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 583 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA Sbjct 584 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 643 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR Sbjct 644 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 703 Query 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 EGQVLS AAPKPLLAQADTEFSGGCAGRSCEF Sbjct 704 EGQVLSSAAPKPLLAQADTEFSGGCAGRSCEF 735 >gi|15607710|ref|NP_215084.1| ribonucleoside-diphosphate reductase large subunit NrdZ [Mycobacterium tuberculosis H37Rv] gi|148660339|ref|YP_001281862.1| putative ribonucleoside-diphosphate reductase subunit alpha [Mycobacterium tuberculosis H37Ra] gi|148821771|ref|YP_001286525.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis F11] 57 more sequence titles Length=692 Score = 1386 bits (3587), Expect = 0.0, Method: Compositional matrix adjust. Identities = 691/692 (99%), Positives = 692/692 (100%), Gaps = 0/692 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 +GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 1 MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA Sbjct 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR Sbjct 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 Query 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF Sbjct 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 >gi|298524058|ref|ZP_07011467.1| ribonucleoside-diphosphate reductase [Mycobacterium tuberculosis 94_M4241A] gi|298493852|gb|EFI29146.1| ribonucleoside-diphosphate reductase [Mycobacterium tuberculosis 94_M4241A] Length=692 Score = 1385 bits (3585), Expect = 0.0, Method: Compositional matrix adjust. Identities = 690/692 (99%), Positives = 692/692 (100%), Gaps = 0/692 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 +GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 1 MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRK+GLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 421 DDVIDVSRYPFPELGEAARATRKVGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA Sbjct 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR Sbjct 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 Query 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF Sbjct 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 >gi|340625597|ref|YP_004744049.1| putative ribonucleoside-diphosphate reductase large subunit NRDZ [Mycobacterium canettii CIPT 140010059] gi|340003787|emb|CCC42913.1| putative ribonucleoside-diphosphate reductase (large subunit) NRDZ (ribonucleotide reductase) [Mycobacterium canettii CIPT 140010059] Length=692 Score = 1382 bits (3577), Expect = 0.0, Method: Compositional matrix adjust. Identities = 688/692 (99%), Positives = 690/692 (99%), Gaps = 0/692 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 + VSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 1 MAVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLA+RLMRRIQQ Sbjct 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLASRLMRRIQQ 480 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPT A Sbjct 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTTA 600 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR Sbjct 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 Query 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF Sbjct 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 >gi|289446117|ref|ZP_06435861.1| ribonucleoside-diphosphate reductase large subunit NrdZ [Mycobacterium tuberculosis CPHL_A] gi|289419075|gb|EFD16276.1| ribonucleoside-diphosphate reductase large subunit NrdZ [Mycobacterium tuberculosis CPHL_A] Length=736 Score = 1368 bits (3541), Expect = 0.0, Method: Compositional matrix adjust. Identities = 685/688 (99%), Positives = 685/688 (99%), Gaps = 1/688 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 44 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 103 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 104 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 163 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 164 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 223 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 224 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 283 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 284 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 343 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 344 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 403 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 404 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 463 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 464 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 523 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 524 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 583 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA Sbjct 584 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 643 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR Sbjct 644 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 703 Query 661 EGQVLSYAAPKPLLAQADTEFS-GGCAG 687 EGQVLSYAAPKPLLAQADTEFS G AG Sbjct 704 EGQVLSYAAPKPLLAQADTEFSRAGIAG 731 >gi|31791752|ref|NP_854245.1| ribonucleoside-diphosphate reductase large subunit NrdZ [Mycobacterium bovis AF2122/97] gi|121636488|ref|YP_976711.1| putative ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224988960|ref|YP_002643647.1| putative ribonucleoside-diphosphate reductase large subunit [Mycobacterium bovis BCG str. Tokyo 172] gi|31617338|emb|CAD93447.1| PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (LARGE SUBUNIT) NRDZ (RIBONUCLEOTIDE REDUCTASE) [Mycobacterium bovis AF2122/97] gi|121492135|emb|CAL70600.1| Probable ribonucleoside-diphosphate reductase (large subunit) nrdZ [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224772073|dbj|BAH24879.1| putative ribonucleoside-diphosphate reductase large subunit [Mycobacterium bovis BCG str. Tokyo 172] gi|341600504|emb|CCC63174.1| probable ribonucleoside-diphosphate reductase (large subunit) nrdZ [Mycobacterium bovis BCG str. Moreau RDJ] Length=710 Score = 1262 bits (3266), Expect = 0.0, Method: Compositional matrix adjust. Identities = 630/631 (99%), Positives = 631/631 (100%), Gaps = 0/631 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 +GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 1 MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI Sbjct 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA Sbjct 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPAT 631 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPAT Sbjct 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPAT 631 >gi|240169273|ref|ZP_04747932.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium kansasii ATCC 12478] Length=696 Score = 1176 bits (3043), Expect = 0.0, Method: Compositional matrix adjust. Identities = 595/688 (87%), Positives = 635/688 (93%), Gaps = 0/688 (0%) Query 5 WPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDI 64 WPA+VRRRD TLVPFDIARIEAAV RAAREVA DDPDMP TVA+AVAD LG IA VE + Sbjct 9 WPAQVRRRDATLVPFDIARIEAAVARAAREVAYDDPDMPATVARAVADTLGPRIASVERV 68 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLH 124 D VEARLGEAGLDDVAR YIIYRQRRAELR KALLGVRDELKLSLAAV VLRERYLL Sbjct 69 GDFVEARLGEAGLDDVARAYIIYRQRRAELRAGKALLGVRDELKLSLAAVMVLRERYLLR 128 Query 125 DEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNSG 184 D +GRP ESTGE+MDR+ARCVAAAED+Y GSS +WAERFATLLRNLEFLPNSPTLMN+G Sbjct 129 DARGRPTESTGEMMDRTARCVAAAEDEYRTGSSAQWAERFATLLRNLEFLPNSPTLMNAG 188 Query 185 TDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTAS 244 TDLGLLAGCFVLP+EDSL+SIFATLGQAAE+QRAGGGTGY FS +RPAGDRVASTGGTAS Sbjct 189 TDLGLLAGCFVLPVEDSLRSIFATLGQAAEVQRAGGGTGYTFSRVRPAGDRVASTGGTAS 248 Query 245 GPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGV 304 GP+SFLRLYD+AA VVSMGGRRRGACMAVLD SHPDICDF++AKAES S L HFNLSVGV Sbjct 249 GPMSFLRLYDTAADVVSMGGRRRGACMAVLDASHPDICDFISAKAESTSHLTHFNLSVGV 308 Query 305 TDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANP 364 DAFLRAVER G HRLVNPRTGK VARMPAAELFDAIC+AAHA GDPGLVFLDTINRANP Sbjct 309 GDAFLRAVERGGAHRLVNPRTGKTVARMPAAELFDAICQAAHACGDPGLVFLDTINRANP 368 Query 365 VPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVI 424 VP RGRIEATNPCGEVPLLPYESCNLGSINLARM+ +G +DWDRL V VAVRFLDDVI Sbjct 369 VPARGRIEATNPCGEVPLLPYESCNLGSINLARMITNGHLDWDRLGAVTEVAVRFLDDVI 428 Query 425 DVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHT 484 DVSRYPFPEL EA RA+RKIGLG+MGLAELLA+LGIPYDS E VRLA ++MRRIQ+ AH Sbjct 429 DVSRYPFPELAEATRASRKIGLGIMGLAELLASLGIPYDSVEGVRLAGQVMRRIQRHAHL 488 Query 485 ASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 ASRRLAE+RG+FPAF DSR R GPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR Sbjct 489 ASRRLAEDRGSFPAFADSRLVRFGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 548 Query 545 AIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAP 604 AIVGR LLEVNPCFDRLARD+GFYRDEL+AEIAQRGGVRGYPRLPAE+RAAFPTAAEIAP Sbjct 549 AIVGRQLLEVNPCFDRLARDQGFYRDELVAEIAQRGGVRGYPRLPAELRAAFPTAAEIAP 608 Query 605 QWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQV 664 QWHLRMQAAVQRHV+AAVSKTVNLPA ATVDDVRA+Y++AW+AKVKGITVYRYGSREGQV Sbjct 609 QWHLRMQAAVQRHVDAAVSKTVNLPAAATVDDVRAVYLSAWRAKVKGITVYRYGSREGQV 668 Query 665 LSYAAPKPLLAQADTEFSGGCAGRSCEF 692 LSYAAP+P+LA+ADTEFSGGCAGRSCEF Sbjct 669 LSYAAPEPVLARADTEFSGGCAGRSCEF 696 >gi|120402409|ref|YP_952238.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium vanbaalenii PYR-1] gi|119955227|gb|ABM12232.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium vanbaalenii PYR-1] Length=698 Score = 1102 bits (2850), Expect = 0.0, Method: Compositional matrix adjust. Identities = 545/689 (80%), Positives = 606/689 (88%), Gaps = 3/689 (0%) Query 5 WPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDI 64 WP +VRRRDGTLVPFDI RIEAAV+RAA EVAC DPDMPGTVA VADALG IAPVE I Sbjct 12 WPTQVRRRDGTLVPFDIGRIEAAVSRAACEVACADPDMPGTVAVTVADALGSAIAPVEKI 71 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLH 124 QD VEARLGEAGLDDVAR YIIYR R AELR+AKALLGVRDELKLSLAAVTVLRERYL H Sbjct 72 QDYVEARLGEAGLDDVARAYIIYRNRHAELRSAKALLGVRDELKLSLAAVTVLRERYLQH 131 Query 125 DEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNSG 184 DE+G P ESTGE+MDR+AR VAAAED+Y PGSS RWA++FAT LR LEFLPNSPTLMN+G Sbjct 132 DERGHPTESTGEMMDRAARYVAAAEDRYLPGSSARWADQFATSLRRLEFLPNSPTLMNAG 191 Query 185 TDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTAS 244 +DLGLL+GC VLP++DSL+SIF+TLG AAE+QR GGGTG+AFS LRPAGDR+ASTGG AS Sbjct 192 SDLGLLSGCVVLPVDDSLRSIFSTLGHAAEVQRCGGGTGFAFSRLRPAGDRIASTGGRAS 251 Query 245 GPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGV 304 GPVSFL L+D+AA VVS+GGRRRGACM VLDVSHPDI +FVTAK +SP L HFNLSVGV Sbjct 252 GPVSFLELFDTAARVVSLGGRRRGACMGVLDVSHPDIQEFVTAKTQSPERLSHFNLSVGV 311 Query 305 TDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANP 364 +D+F+RAVER +HRLVNPRTG+ VA++ A ELFD IC++AHA GDPGLVFLDT+NRANP Sbjct 312 SDSFMRAVERGDVHRLVNPRTGRTVAKVSAVELFDVICESAHACGDPGLVFLDTVNRANP 371 Query 365 VPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVI 424 VP GRIEATNPCGEVPLLP ESCNLGS+NLARM+ DGR+DW RL +V +AVRFLDDVI Sbjct 372 VPRLGRIEATNPCGEVPLLPNESCNLGSLNLARMVTDGRIDWCRLRDVTALAVRFLDDVI 431 Query 425 DVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHT 484 DVSRYPF EL A RATRKIGLGVMGLAE+LA+LGIPYDS++AVRLA R+M R+Q+ AH Sbjct 432 DVSRYPFDELDAAGRATRKIGLGVMGLAEVLASLGIPYDSDDAVRLAGRIMGRVQRVAHE 491 Query 485 ASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 S +LA ERG FPA+ DSR R PRRNAQ+TSVAPTGTISLIAGTTAGIEPMFAIA+TR Sbjct 492 TSEQLAAERGPFPAYPDSRLTR--PRRNAQLTSVAPTGTISLIAGTTAGIEPMFAIAYTR 549 Query 545 AIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGY-PRLPAEVRAAFPTAAEIA 603 A+VGRHLLEVNPCFDR+AR RGFY DELI EIA+ GGVRGY LPA+VRAAFPTAAEI+ Sbjct 550 AVVGRHLLEVNPCFDRMARRRGFYTDELITEIARSGGVRGYRGDLPADVRAAFPTAAEIS 609 Query 604 PQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQ 663 P+WHLRMQAAVQRHV+AAVSKTVNLP AT DDVRAIY++AWKAKVKGITVYRYGSR+GQ Sbjct 610 PEWHLRMQAAVQRHVDAAVSKTVNLPEAATADDVRAIYLSAWKAKVKGITVYRYGSRQGQ 669 Query 664 VLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 VLSYAAP P + AD EFSGGC GRSCE Sbjct 670 VLSYAAPPPQVPHADLEFSGGCVGRSCEM 698 >gi|108798058|ref|YP_638255.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium sp. MCS] gi|119867154|ref|YP_937106.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium sp. KMS] gi|126433719|ref|YP_001069410.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium sp. JLS] gi|108768477|gb|ABG07199.1| Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium sp. MCS] gi|119693243|gb|ABL90316.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium sp. KMS] gi|126233519|gb|ABN96919.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Mycobacterium sp. JLS] Length=693 Score = 1096 bits (2835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 540/688 (79%), Positives = 600/688 (88%), Gaps = 0/688 (0%) Query 5 WPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDI 64 WP +VRRRDGTLVPFD RIEAAV RAAREVACDDPDMPG VA+ VAD LG G A VE I Sbjct 6 WPTRVRRRDGTLVPFDAGRIEAAVLRAAREVACDDPDMPGAVARTVADTLGPGTADVETI 65 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLH 124 QD VEARLGEAGLDDVAR YI+YR+ RA+LR AKALLGVRDELKLSLAAVTVLRERYLL Sbjct 66 QDFVEARLGEAGLDDVARAYIVYRRDRADLRAAKALLGVRDELKLSLAAVTVLRERYLLR 125 Query 125 DEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNSG 184 D++GRP ESTGE+MDR+ARCVAAAED YEPGSS W +RF+ LR+LEFLPNSPTLMN+G Sbjct 126 DQRGRPVESTGEMMDRAARCVAAAEDAYEPGSSAEWTDRFSRGLRDLEFLPNSPTLMNAG 185 Query 185 TDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTAS 244 TDLGLL+GCFVLP+EDSL+SIFATL +AAE+QRAGGGTG++FS +RP GD + +T G+A Sbjct 186 TDLGLLSGCFVLPVEDSLRSIFATLAKAAEIQRAGGGTGFSFSRIRPDGDPITTTTGSAC 245 Query 245 GPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGV 304 GPV F+ L+D+AA VVS+GGRRRGACMAVLDVSHPDI DF+ +K+ S ++LPHFNLS+GV Sbjct 246 GPVPFVGLFDAAAQVVSLGGRRRGACMAVLDVSHPDIYDFIASKSGSTAKLPHFNLSIGV 305 Query 305 TDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANP 364 DAF+RAVE G+HRLVNPRTGK AR+ A ELF AIC+AA+ GGDPGLVFLDTINRANP Sbjct 306 GDAFMRAVESGGMHRLVNPRTGKTAARVRADELFAAICEAANHGGDPGLVFLDTINRANP 365 Query 365 VPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVI 424 VP RGRIEATNPCGEVPLLPYESCNLGS+NL RML VDW RL V +AVRF DDVI Sbjct 366 VPQRGRIEATNPCGEVPLLPYESCNLGSVNLTRMLTGDEVDWTRLTAVTEMAVRFFDDVI 425 Query 425 DVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHT 484 DVSRYPF ELGEA RATRKIGLGVMGLAE+LA LGIPYDSEEA+RL R+MR IQ+AAH Sbjct 426 DVSRYPFAELGEATRATRKIGLGVMGLAEMLARLGIPYDSEEALRLTDRVMRHIQRAAHR 485 Query 485 ASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 ASRRLAE+RG+FPAF DSR RSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIA+TR Sbjct 486 ASRRLAEDRGSFPAFPDSRLVRSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAYTR 545 Query 545 AIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAP 604 AI+GRHLLEVNP FDRLARDRGFYRDELI EIA+RGGVR P LPAEVR+AFPTA EI+P Sbjct 546 AILGRHLLEVNPTFDRLARDRGFYRDELITEIAERGGVRRCPSLPAEVRSAFPTATEISP 605 Query 605 QWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQV 664 WHLRMQA VQRHV+AAVSKTVNLP+TAT DVR IY+ AWKAKVKG+TVYRYGSRE QV Sbjct 606 DWHLRMQAVVQRHVDAAVSKTVNLPSTATPADVRDIYLKAWKAKVKGVTVYRYGSREDQV 665 Query 665 LSYAAPKPLLAQADTEFSGGCAGRSCEF 692 L++AAP + QA +FSGGCA RSCEF Sbjct 666 LTFAAPPGMPVQAPADFSGGCAQRSCEF 693 >gi|296170901|ref|ZP_06852438.1| ribonucleoside-diphosphate reductase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894450|gb|EFG74194.1| ribonucleoside-diphosphate reductase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=701 Score = 1021 bits (2640), Expect = 0.0, Method: Compositional matrix adjust. Identities = 513/692 (75%), Positives = 572/692 (83%), Gaps = 4/692 (0%) Query 5 WPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADAL-GR---GIAP 60 WP+ VRRRDG LVPFD+ARIE A+ RAARE DP +P +A++VADAL GR GI Sbjct 10 WPSNVRRRDGRLVPFDVARIETAIGRAAREAGHRDPQLPALLARSVADALVGRFRSGIPT 69 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VE IQD VEARL GLDDVAR Y +YR++ AELR K LLGVRDELKLS+AAVTVL ER Sbjct 70 VEGIQDLVEARLTADGLDDVARAYAVYRRQHAELRATKELLGVRDELKLSVAAVTVLGER 129 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLL D++GRP ESTGE+MDR A VA AE+++ PGSS +WA+RF+ LLR LEFLPNSPTL Sbjct 130 YLLRDDRGRPVESTGEMMDRVADHVAGAEEKFRPGSSAQWAQRFSALLRGLEFLPNSPTL 189 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MN+GT+LGLL+GCFVLP++DSL SIF L Q A++ +AGGGTGY FSHLRP GD V TG Sbjct 190 MNAGTELGLLSGCFVLPVDDSLHSIFTALAQGADIHQAGGGTGYTFSHLRPTGDLVVRTG 249 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGP+SFLRL+D AA V+SMGGRRRGA MAVLDVSHPDI DFVTAK+ S +EL FNL Sbjct 250 GTASGPLSFLRLFDYAAAVISMGGRRRGASMAVLDVSHPDIYDFVTAKSGSQTELNQFNL 309 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTD FLRAV R G HRLVNPRTGK A + AA+LF AIC+AAH GDPGLVFLDTIN Sbjct 310 SVGVTDEFLRAVGRGGSHRLVNPRTGKTAATVSAADLFTAICEAAHRCGDPGLVFLDTIN 369 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANP P GRIEATNPCGEVPLLPYESCNLGSINLARM+ G VDW+RL VA +AVRFL Sbjct 370 RANPTPALGRIEATNPCGEVPLLPYESCNLGSINLARMVGAGGVDWERLTAVAELAVRFL 429 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSR PFPE+ A ATRKIGLGVMGLAELLA LGIPYDSE VRLA R+ R + + Sbjct 430 DDVIDVSRLPFPEVEAATTATRKIGLGVMGLAELLAGLGIPYDSERGVRLAARIARTVNR 489 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI 540 AAH AS RLAEERG FPAF SRFA S PRRNAQ+TS+APTGTISLIAGT+AGIEPMFAI Sbjct 490 AAHAASERLAEERGPFPAFGHSRFAGSAPRRNAQLTSIAPTGTISLIAGTSAGIEPMFAI 549 Query 541 AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA 600 A+ RA++GR LLEVNPCFDRLARDRGFY +LIAEIA+ GGVR P +PAEVRAAFPTAA Sbjct 550 AYIRAVIGRRLLEVNPCFDRLARDRGFYHPDLIAEIARHGGVRRDPHVPAEVRAAFPTAA 609 Query 601 EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSR 660 EIAP+WHLRMQAAVQRHV+AAVSKTVNLPA +TV+DVR IY+AAW+A+VKGITVYRYGSR Sbjct 610 EIAPEWHLRMQAAVQRHVDAAVSKTVNLPAESTVEDVRTIYLAAWRARVKGITVYRYGSR 669 Query 661 EGQVLSYAAPKPLLAQADTEFSGGCAGRSCEF 692 GQVLSY L AD FSGGC GR CEF Sbjct 670 AGQVLSYVGTDEALLAADATFSGGCLGRRCEF 701 >gi|289749069|ref|ZP_06508447.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis T92] gi|289689656|gb|EFD57085.1| ribonucleoside-diphosphate reductase large subunit nrdZ [Mycobacterium tuberculosis T92] Length=611 Score = 1019 bits (2635), Expect = 0.0, Method: Compositional matrix adjust. Identities = 509/509 (100%), Positives = 509/509 (100%), Gaps = 0/509 (0%) Query 1 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 60 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP Sbjct 44 VGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP 103 Query 61 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 120 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER Sbjct 104 VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER 163 Query 121 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 180 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL Sbjct 164 YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL 223 Query 181 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 240 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG Sbjct 224 MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG 283 Query 241 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 300 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL Sbjct 284 GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL 343 Query 301 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 360 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN Sbjct 344 SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN 403 Query 361 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 420 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL Sbjct 404 RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL 463 Query 421 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 480 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ Sbjct 464 DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ 523 Query 481 AAHTASRRLAEERGAFPAFTDSRFARSGP 509 AAHTASRRLAEERGAFPAFTDSRFARSGP Sbjct 524 AAHTASRRLAEERGAFPAFTDSRFARSGP 552 >gi|298674718|ref|YP_003726468.1| ribonucleoside-diphosphate reductase [Methanohalobium evestigatum Z-7303] gi|298287706|gb|ADI73672.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanohalobium evestigatum Z-7303] Length=695 Score = 691 bits (1783), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/691 (48%), Positives = 466/691 (68%), Gaps = 15/691 (2%) Query 9 VRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADAL----GRGIAPVEDI 64 +++RDG V FD +I A+ +A V +D D+ ++ V D L I VED+ Sbjct 4 IKKRDGRTVDFDSDKITQAIHKAIHSVNENDGDLARKMSYQVIDNLENRFKNTIPSVEDV 63 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVR-DELKLSLAAVTVLRERYLL 123 QD VE L + G +VA+ YI+YR++R+E+R K LG++ D+LKLS+ A+ VL RYLL Sbjct 64 QDIVEDVLIKNGYSEVAKSYILYRRKRSEVRETKKYLGIKHDDLKLSVNAIRVLERRYLL 123 Query 124 HDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNS 183 E G P E+ E+ +R A V++ + +Y AE F ++ NLEFLPNSPTLMN+ Sbjct 124 KGENGNPVETPSEMFERVANSVSSIDKRYGYNPYDSKAE-FYRMMSNLEFLPNSPTLMNA 182 Query 184 GTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTA 243 GT+LG L+ CFVLP+EDS++ IF L + + ++GGGTG++FS LRP GD V ST G A Sbjct 183 GTELGQLSACFVLPVEDSMKDIFEALTNMSLIHKSGGGTGFSFSKLRPNGDIVKSTKGVA 242 Query 244 SGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVG 303 SGPVSF+ ++D A V+ GG+RRGA M +L + HPDI +F+ +K E L +FN+SVG Sbjct 243 SGPVSFMSIFDQATEVIKQGGKRRGANMGILRIDHPDIIEFINSK-EKEGYLDNFNISVG 301 Query 304 VTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRAN 363 VTD F++AV+ + + L+NPRTGK ++ A ++FD I A GDPG++FLD INR + Sbjct 302 VTDEFMKAVQSDSKYDLINPRTGKTTEKLRARDIFDLITTMAWRTGDPGMIFLDEINRRH 361 Query 364 PVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDV 423 PV IE+TNPCGEVPLLPYESCNLGSINL++M+ + ++W++L+ + FLD+V Sbjct 362 PVSHVRTIESTNPCGEVPLLPYESCNLGSINLSKMVKNDTINWEKLKNNTHSGIHFLDNV 421 Query 424 IDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAH 483 ID ++YP E+ + RKIGLGVMGLAE+ A L IPY+SEEA+ A +M+ I + + Sbjct 422 IDANKYPLNEIDRETKNNRKIGLGVMGLAEMFAKLNIPYNSEEAIETAENIMKFINEESV 481 Query 484 TASRRLAEERGAFPAFTDSRFARS-GPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAF 542 S L E+RG+FP F S++ + RNA V ++APTGTIS+IA T++GIEP+FA++F Sbjct 482 KKSVELGEKRGSFPNFKGSQWEKKYSSMRNATVNTIAPTGTISIIANTSSGIEPIFALSF 541 Query 543 TRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEI 602 R ++ LLEVNP F+ +A++R FY +L+ +I++ G ++ ++P +VR F T+ +I Sbjct 542 VRNVMATQLLEVNPVFENVAKERNFYSKDLMMDISKTGSIQNLKQVPKDVRDLFVTSLDI 601 Query 603 APQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREG 662 P+WH+RMQAA Q++V+ +VSKTVNLP AT+DDV+ IY+ A+K KGIT+YRYGS+E Sbjct 602 DPEWHVRMQAAFQKYVDNSVSKTVNLPEKATLDDVKRIYMMAYKLNCKGITIYRYGSKEN 661 Query 663 QVLSYAAPKPLLAQ---ADTEFSG----GCA 686 QVL K + AD+EFSG GC+ Sbjct 662 QVLELGGLKKEKGEGIIADSEFSGDYLTGCS 692 >gi|330507668|ref|YP_004384096.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanosaeta concilii GP6] gi|328928476|gb|AEB68278.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanosaeta concilii GP6] Length=676 Score = 659 bits (1699), Expect = 0.0, Method: Compositional matrix adjust. Identities = 344/663 (52%), Positives = 453/663 (69%), Gaps = 10/663 (1%) Query 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVA----DALGRGIAPVED 63 ++R+R+G +V F +I A+++A R V ++ D P +A+ VA + R I VE+ Sbjct 4 RIRKREGRVVEFQTEKIALAISKAFRAVGREEEDAPFRLAERVAKEAEERFSRTIPGVEE 63 Query 64 IQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLL 123 IQD VE L AG DVA+ YI+YRQ+R E+R AK LGV D+LKLS+ A VL++RYLL Sbjct 64 IQDLVERALISAGYADVAKAYILYRQKRTEIREAKRYLGVADDLKLSVNAAEVLKKRYLL 123 Query 124 HDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNS 183 DE+G E+ GE+ R A ++ AE +Y G + F ++RNLEFLPNSPTLMNS Sbjct 124 RDERGDVVETPGEMFGRVADHISKAESKY-GGDVESYRSLFLQMMRNLEFLPNSPTLMNS 182 Query 184 GTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTA 243 +LG L+ CFVLP+ DSL IF L A + ++GGGTG++FS LRP D V +TGG A Sbjct 183 RLELGQLSACFVLPVTDSLPGIFDALKNMALIHQSGGGTGFSFSRLRPKDDVVRATGGVA 242 Query 244 SGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVG 303 SGPVSF+R++D+A V+ GGRRRGA M +L V HPDI +F+ AK E P L +FNLSV Sbjct 243 SGPVSFMRIFDTATDVIKQGGRRRGANMGILRVDHPDIMEFIEAK-ERPGFLENFNLSVA 301 Query 304 VTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRAN 363 TD F+ G L+NPRTG R+ AAEL I +A GGDPG++F+D IN A+ Sbjct 302 ATDEFMEKSRGEGEIDLINPRTGLAGGRLKAAELLGLIATSAWRGGDPGIIFIDRINAAH 361 Query 364 PVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDV 423 P+PG IEATNPCGE PLLPYESCNLGSINL+R++ G +DWDRL E+ +AVRFLDDV Sbjct 362 PLPGE--IEATNPCGEQPLLPYESCNLGSINLSRLVRKGELDWDRLAELVSLAVRFLDDV 419 Query 424 IDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAH 483 ID++R+P P++ EA + RKIGLGVMG A++L + I Y S +AV LA +LM I + A Sbjct 420 IDMNRFPLPQIEEATLSRRKIGLGVMGFADMLIQMNISYASPQAVALAEKLMGFISEHAR 479 Query 484 TASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFT 543 S RL EERG+FP F SR RNA VT++APTGTIS+IAGT++GIEP+FA+AF Sbjct 480 AQSARLGEERGSFPLFDSSRLRGWSAMRNATVTTIAPTGTISIIAGTSSGIEPLFALAFV 539 Query 544 RAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEI 602 R ++ G LLEV+P F+++A +RG Y +L E+A RG V+ LP +++ F TA +I Sbjct 540 RRVLEGARLLEVSPLFEKMAMERGIYTPDLKVELAWRGSVQEIAGLPQDLKELFRTALDI 599 Query 603 APQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREG 662 + Q H+R+QAA Q++ + AVSKTVNLPA ATV DV +Y A+ KG+TV+RYGSR Sbjct 600 SAQQHVRIQAAFQKYTDNAVSKTVNLPAEATVSDVLQVYRLAYDLGCKGVTVFRYGSR-S 658 Query 663 QVL 665 QVL Sbjct 659 QVL 661 >gi|116754614|ref|YP_843732.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanosaeta thermophila PT] gi|116666065|gb|ABK15092.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanosaeta thermophila PT] Length=688 Score = 654 bits (1688), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/677 (50%), Positives = 458/677 (68%), Gaps = 11/677 (1%) Query 2 GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGR----G 57 G+ ++R+RDG +V FD +RI A+++A + D P +A V D + Sbjct 9 GIELVERIRKRDGRIVDFDPSRISRAISKAFNALGIVDEKTPVELAGRVVDVVDERFRDE 68 Query 58 IAPVEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVL 117 I VED+QD VE L +AG VA+ YI+YRQRR+E+R AK LGV D+LKLS+ A+ VL Sbjct 69 IPSVEDVQDIVEEVLIDAGYAQVAKAYILYRQRRSEIREAKHYLGVADDLKLSVNAIEVL 128 Query 118 RERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNS 177 ++RYL DE G E+ GE+ +R A V+A E +YE G + ++F +++R+L FLPNS Sbjct 129 KKRYLKRDEFGNVVETPGEMFERVASAVSAVERRYE-GDADDARKKFLSMMRSLSFLPNS 187 Query 178 PTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVA 237 PTLMN+G LG L+ CFV+P+EDS+ IF L A + ++GGGTG++FS LRP GD V Sbjct 188 PTLMNAGLPLGQLSACFVVPVEDSIAGIFDALKYMALIHQSGGGTGFSFSRLRPKGDVVR 247 Query 238 STGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPH 297 STGG ASGPVSF+R++D+A V+ GGRRRGA M +L V HPDI +F+ K + + Sbjct 248 STGGIASGPVSFMRIFDAATDVIKQGGRRRGANMGILRVDHPDITEFIACKDRGG--MDN 305 Query 298 FNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLD 357 FN+SV +T+ F+R ER+G L+NPRTG+ M A +L + A GDPG+VF+D Sbjct 306 FNISVAITEEFMRQCERDGSVELINPRTGEATGEMSARDLMVMMATYAWRRGDPGVVFID 365 Query 358 TINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAV 417 IN +PVPG IEATNPCGE PLLP+ESCNLGS+NL+RM+ G + WDRLEE +AV Sbjct 366 RINALHPVPGI--IEATNPCGEQPLLPFESCNLGSVNLSRMVERGEISWDRLEETVRLAV 423 Query 418 RFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRR 477 RFLDDVID +R+P ++ +A TRKIGLGVMG AE+L LG+ Y S++A+R+A LM Sbjct 424 RFLDDVIDANRFPLKQIEDATLRTRKIGLGVMGFAEMLIQLGVSYASQDALRIAEELMAF 483 Query 478 IQQAAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPM 537 I + A S L ERG+FP F +S + RNA VT++APTGTIS+IAGT++GIEP+ Sbjct 484 ITKTAREESCALGRERGSFPLFEESSLKKWDAMRNATVTTIAPTGTISIIAGTSSGIEPL 543 Query 538 FAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAF 596 FA++F R ++ G L+E +P F+R+A +RG L AE+A+RG ++ P +P +++ F Sbjct 544 FAVSFVRHVLEGARLIESSPLFERMASERGIMTPALRAEVARRGSIQEIPGIPDDIKELF 603 Query 597 PTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYR 656 TA +I+P+ H+R+QAA Q+H + AVSKTVNLP A+V DV +Y A++ KGITVYR Sbjct 604 LTALDISPEQHVRIQAAFQKHTDNAVSKTVNLPEKASVSDVIKVYRLAYELGCKGITVYR 663 Query 657 YGSREGQVLSYAAPKPL 673 YGSRE QVL P L Sbjct 664 YGSRE-QVLYLGEPDAL 679 >gi|254169166|ref|ZP_04876002.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|289596591|ref|YP_003483287.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|197621901|gb|EDY34480.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|289534378|gb|ADD08725.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] Length=768 Score = 610 bits (1574), Expect = 2e-172, Method: Compositional matrix adjust. Identities = 323/726 (45%), Positives = 457/726 (63%), Gaps = 64/726 (8%) Query 6 PAKVRRRDGTLVPFDIARIEAAVTRAAREVA-CDDPD-MPGTVAKAVADALGRGIAP-VE 62 P+ +++R G V +D RI A+ +A E D P+ + ++K V + + + P VE Sbjct 2 PSLIKKRSGDYVLYDRKRIANAIKKAFLETGEVDTPEEIADELSKIVEERIQKYEIPSVE 61 Query 63 DIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYL 122 IQD VE L E A+ YI+YR+ R ++R AK +LGV D+LKL++ A+ VL RYL Sbjct 62 QIQDEVEKLLMEKKYTRTAKAYIVYRETRKKVREAKKILGVEDDLKLTVNAIKVLEARYL 121 Query 123 LHDEQGRPAESTGELMDRSARCVAAAEDQY------EPGSSRRWAERFA----------- 165 L DE+G+ E+ ++ R+AR +A + Y G +R E FA Sbjct 122 LKDEKGKIIETPRQMFYRTARYIALVDALYFDEVFDLSGKQKRRNEVFAGKSNLGVYEMD 181 Query 166 -----------------------------------------TLLRNLEFLPNSPTLMNSG 184 +++ N F+PNSPTLMNS Sbjct 182 MLKRAYRRLNFKGHMKVDFSEFIRILNDKWDIIEERIKEFYSIMVNRYFIPNSPTLMNSN 241 Query 185 TDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTAS 244 T LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++FS LRP GD VAST G AS Sbjct 242 TRLGQLSACFVLPVPDSIEGIFNAVKYAAMIHKSGGGTGFSFSRLRPKGDIVASTMGVAS 301 Query 245 GPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGV 304 GP+SF+R++D A V+ GG+RRGA M VL V HPDI +F+T+K L +FN+SV V Sbjct 302 GPLSFMRVFDVATDVIKQGGKRRGANMGVLSVHHPDILEFITSKDSENKVLSNFNISVAV 361 Query 305 TDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANP 364 TD F+ A+ R+ + L NPR G+ V R+ A +++D I A GDPG++F+D +NR +P Sbjct 362 TDEFMDALLRDDYYPLRNPRNGEEVKRIKARQVWDLIITQAWKTGDPGVIFIDEVNRKHP 421 Query 365 VPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVI 424 V G IE+TNPCGE PLLPYESCNLGSINL+ + +G++ WD+L +V +A+ FLD+VI Sbjct 422 VKHLGEIESTNPCGEQPLLPYESCNLGSINLSLFVENGKIKWDKLRKVIHIAIHFLDNVI 481 Query 425 DVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHT 484 D +RYP P++ TRKIGLGVMG AE+L LGIPYDSEEAV LA ++M+ I + +H Sbjct 482 DANRYPLPQIERMTLLTRKIGLGVMGWAEMLIKLGIPYDSEEAVELAEKVMKFINEESHR 541 Query 485 ASRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFT 543 AS +LAE+RG FPA+ S + + G + RNA T++APTGTIS+IAGT++ IEP+FAI + Sbjct 542 ASMKLAEKRGVFPAWEGSEWWKKGMKIRNATTTTIAPTGTISIIAGTSSSIEPLFAIVYV 601 Query 544 RAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEI 602 R ++ G LLE+NP F+ +A+ RGFY ++L+ EIA+ G ++ +P +V+ F TA +I Sbjct 602 RRVLEGEELLEINPLFEEIAKKRGFYSEDLMLEIAKSGSIQNLD-VPEDVKRIFKTAHDI 660 Query 603 APQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREG 662 P WH+ MQAA Q++V+ AVSKTVNL AT +DV +Y+ A++ K KGIT+YR S++ Sbjct 661 GPSWHVAMQAAFQKYVDNAVSKTVNLRYDATPEDVEKVYMLAYQLKCKGITIYRDKSKKE 720 Query 663 QVLSYA 668 QV+ A Sbjct 721 QVIDKA 726 >gi|294496479|ref|YP_003542972.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanohalophilus mahii DSM 5219] gi|292667478|gb|ADE37327.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanohalophilus mahii DSM 5219] Length=596 Score = 608 bits (1567), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 293/561 (53%), Positives = 393/561 (71%), Gaps = 3/561 (0%) Query 106 ELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFA 165 E +LS T+L +RYLL D +G+ AE GEL R A+ +A + +Y + + F Sbjct 13 ESRLSANGKTLLEKRYLLRDAEGKVAEEPGELFARVAKTIARVDSRY-GYDVEKTEDDFY 71 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 ++ +LEFLPNSPTLMN+GT+LG L+ CFVLP+EDSL+SIF +L + + ++GGGTG++ Sbjct 72 QVMADLEFLPNSPTLMNAGTELGQLSACFVLPVEDSLKSIFKSLQDMSLIHQSGGGTGFS 131 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS+LRP GD V ST G ASGP+SF+ ++D A V+ GGRRRGA M VL V HPDI +F+ Sbjct 132 FSNLRPKGDIVGSTNGVASGPLSFMTIFDKATDVIKQGGRRRGANMGVLRVDHPDIIEFI 191 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 AK E L +FNLSVGVTD F+ AV ++ + L+NPRTGKI R+ A ++FD I A Sbjct 192 RAK-EDEELLRNFNLSVGVTDEFMEAVSQDRDYALINPRTGKIEKRLKAKDVFDRIVTCA 250 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVD 405 GDPGL+FLD INR +P+ G IE+TNPCGEVPLLPYESCNLGSINLA+M+ +G +D Sbjct 251 CRTGDPGLLFLDEINRRHPLSTIGTIESTNPCGEVPLLPYESCNLGSINLAQMVKEGAID 310 Query 406 WDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSE 465 W++L++ V FLD+VID ++YP P++G+ + RKIGLGVMG A +LA LGIPYD Sbjct 311 WEKLKQTVHTGVHFLDNVIDANKYPLPQIGQRTKQNRKIGLGVMGFAAMLARLGIPYDCR 370 Query 466 EAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGP-RRNAQVTSVAPTGTI 524 E + A ++M+ Q + S L E+RG+FP F S AR P RNA V +VAPTG++ Sbjct 371 EGIATAEKVMKFTQDESVQKSVELGEQRGSFPNFHRSALARDYPAMRNATVNTVAPTGSL 430 Query 525 SLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 S+IA TT+GIEPMFA+ + R ++G L E++P F+ +AR GFY +L+ EIA G ++ Sbjct 431 SIIANTTSGIEPMFALTYRRNVMGTRLTEIDPVFEEIARKHGFYSSQLMEEIAGTGSLQT 490 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 P +P + R F TA EI P+WH+RMQAA Q+HV+ AV+KTVNLP ATV+D R +Y+ A Sbjct 491 SPNIPEQTRRIFATALEIQPRWHVRMQAAFQKHVDNAVAKTVNLPHEATVEDFREVYMLA 550 Query 645 WKAKVKGITVYRYGSREGQVL 665 ++ K KGI YRYGS+ QVL Sbjct 551 YRLKCKGIAAYRYGSKAEQVL 571 >gi|11499254|ref|NP_070492.1| ribonucleotide-diphosphate reductase subunit alpha [Archaeoglobus fulgidus DSM 4304] gi|2648891|gb|AAB89584.1| ribonucleotide reductase (nrd) [Archaeoglobus fulgidus DSM 4304] Length=752 Score = 606 bits (1562), Expect = 5e-171, Method: Compositional matrix adjust. Identities = 295/562 (53%), Positives = 410/562 (73%), Gaps = 5/562 (0%) Query 107 LKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFAT 166 +KL+ A TVLR+RYLL D++G E+ E+ R AR +A AE+ Y ++ WAE+F Sbjct 1 MKLNRTAETVLRKRYLLKDDEGNVIETPEEMCWRVARAIAKAEENY-GNNAEEWAEKFFK 59 Query 167 LLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAF 226 LL +F+PNSPTLMN+GT+L L+ CFV+P+EDS+ IF L A++Q++GGGTG++F Sbjct 60 LLWEQKFMPNSPTLMNAGTELNQLSACFVIPVEDSIDGIFKALWDMAKVQKSGGGTGFSF 119 Query 227 SHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVT 286 S LRP GD V ST G ASGPVSF++++D+A + GGRRRGA M VL+V HPDI +F+ Sbjct 120 SRLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGRRRGANMGVLNVHHPDIEEFIK 179 Query 287 AKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAH 346 AK E L +FN+SV TDAF+ A++++ + L+NPRTG++V R+PA ++F+ I + A Sbjct 180 AKWEE-GVLRNFNISVAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAW 238 Query 347 AGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDW 406 G+PG++F+DTINR NP P G+IEATNPCGE PLLPYESCNLGSINLA+ + DG +DW Sbjct 239 RNGEPGMIFIDTINRFNPTPHVGQIEATNPCGEQPLLPYESCNLGSINLAKFVKDGEIDW 298 Query 407 DRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEE 466 D L EV +AVRFLDDVIDV+ YP PE+ + +A RKIGLGVMG A++L L IPYDS+E Sbjct 299 DGLREVVWIAVRFLDDVIDVNSYPIPEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDE 358 Query 467 AVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTIS 525 A++LA ++M+ IQ+ +H AS++LAEERG FP + S + + G + RNA T++APTGTIS Sbjct 359 AIQLAEKVMKFIQEESHRASQQLAEERGVFPNWKGSVWEKKGIKMRNATTTTIAPTGTIS 418 Query 526 LIAGTTAGIEPMFAIAFTRAIV--GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVR 583 +IAG ++GIEP+FA+A+ R + G E+N F+ + R RG Y DELI ++A++G ++ Sbjct 419 IIAGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEKGSIQ 478 Query 584 GYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVA 643 +P ++R F A +I+P+WH+RMQAA Q++ + AVSKT+N+P +AT DV ++ Sbjct 479 EIEEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFLL 538 Query 644 AWKAKVKGITVYRYGSREGQVL 665 A++ KGITVYR GSRE QVL Sbjct 539 AYELGCKGITVYRDGSREEQVL 560 >gi|254169182|ref|ZP_04876017.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|197621840|gb|EDY34420.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] Length=768 Score = 603 bits (1556), Expect = 3e-170, Method: Compositional matrix adjust. Identities = 321/726 (45%), Positives = 454/726 (63%), Gaps = 64/726 (8%) Query 6 PAKVRRRDGTLVPFDIARIEAAVTRAAREVA-CDDPD-MPGTVAKAVADALGRGIAP-VE 62 P+ +++R G V +D RI A+ +A E D P+ + ++K V + + + P VE Sbjct 2 PSLIKKRSGDYVLYDRKRIANAIKKAFLETGEVDTPEEIADELSKIVEERIQKYEIPSVE 61 Query 63 DIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYL 122 IQD VE L E A+ YI+YR+ R ++R AK +LGV D+LKL++ A+ VL RYL Sbjct 62 QIQDEVEKLLMEKKYTRTAKAYIVYRETRKKVREAKKILGVEDDLKLTVNAIKVLEARYL 121 Query 123 LHDEQGRPAESTGELMDRSARCVAAAEDQY------EPGSSRRWAERFA----------- 165 L DE+GR E+ ++ R+AR +A + Y G +R E FA Sbjct 122 LKDEKGRIIETPRQMFYRTARYIALVDALYFDEVFDLSGKQKRRNEIFAGKSNLGVYERD 181 Query 166 -----------------------------------------TLLRNLEFLPNSPTLMNSG 184 +++ N F+PNSPTLMNS Sbjct 182 MLKRAYRRLNFKGHMKVDFSEFIRILNDKWDIIEERIKEFYSIMVNRYFIPNSPTLMNSN 241 Query 185 TDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTAS 244 T LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++FS LRP GD VAST G AS Sbjct 242 TRLGQLSACFVLPVPDSIEGIFNAVKYAAMIHKSGGGTGFSFSRLRPKGDIVASTMGVAS 301 Query 245 GPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGV 304 GP+SF+R++D A V+ GG+RRGA M VL V HPDI +F+T+K L +FN+SV V Sbjct 302 GPLSFMRVFDVATDVIKQGGKRRGANMGVLSVHHPDILEFITSKDSENKVLSNFNISVAV 361 Query 305 TDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANP 364 D F+ A+ R+ + L NPR G+ V R+ A +++D I A GDPG++F+D +NR +P Sbjct 362 MDEFMDALLRDDYYPLRNPRNGEEVKRIKARQVWDLIITQAWKTGDPGVIFIDEVNRKHP 421 Query 365 VPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVI 424 V G IE+TNPCGE PLLPYESCNLGSINL+ + +G++ W +L +V +A+ FLD+VI Sbjct 422 VKHLGEIESTNPCGEQPLLPYESCNLGSINLSLFVENGKIKWHKLRKVIHIAIHFLDNVI 481 Query 425 DVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHT 484 D +RYP P++ TRKIGLGVMG AE+L LGIPYDSEEAV LA ++M+ I + +H Sbjct 482 DANRYPLPQIERMTLLTRKIGLGVMGWAEMLIKLGIPYDSEEAVELAEKVMKFINEESHR 541 Query 485 ASRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFT 543 AS +LAE+RG FPA+ S + + G + RNA T++APTGTIS+IAGT++ IEP+FAI + Sbjct 542 ASMKLAEKRGVFPAWEGSEWWKKGMKIRNATTTTIAPTGTISIIAGTSSSIEPLFAIVYV 601 Query 544 RAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEI 602 R ++ G LLE+NP F+ +A+ GFY ++L+ EIA+ G ++ +P +V+ F TA +I Sbjct 602 RRVLEGEELLEINPLFEEIAKKGGFYSEDLMLEIAKSGSIQNLD-VPEDVKRIFKTAHDI 660 Query 603 APQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREG 662 P WH+ MQAA Q++V+ AVSKTVNL AT +DV +Y+ A++ K KGIT+YR S++ Sbjct 661 GPSWHVAMQAAFQKYVDNAVSKTVNLRYDATPEDVEKVYMLAYQLKCKGITIYRDKSKKE 720 Query 663 QVLSYA 668 QV+ A Sbjct 721 QVIDKA 726 >gi|291279559|ref|YP_003496394.1| ribonucleoside-diphosphate reductase alpha chain [Deferribacter desulfuricans SSM1] gi|290754261|dbj|BAI80638.1| ribonucleoside-diphosphate reductase alpha chain [Deferribacter desulfuricans SSM1] Length=768 Score = 601 bits (1549), Expect = 2e-169, Method: Compositional matrix adjust. Identities = 286/566 (51%), Positives = 397/566 (71%), Gaps = 5/566 (0%) Query 105 DELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAER 163 +E KLS A+TVLR+RYL DE+G E+ + R A +A A+ Y+ + + A+ Sbjct 12 EEPKLSANALTVLRKRYLKKDEKGNIVETPKGMFQRVAMNIALADLNYDKNADIEKTAKE 71 Query 164 FATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTG 223 F ++ +L+FLPNSPTLMN+G +L L+ CFVLP+EDSL IF + A + ++GGGTG Sbjct 72 FFDIMVSLKFLPNSPTLMNAGKELQQLSACFVLPVEDSLDKIFEAVKYTALIHKSGGGTG 131 Query 224 YAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICD 283 ++FS LRP D V +T G +SGPVSF+ ++DSA + GG RRGA M +L V HPDI + Sbjct 132 FSFSRLRPKDDVVKTTKGVSSGPVSFMTVFDSATETIKQGGTRRGANMGILRVDHPDIME 191 Query 284 FVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICK 343 F+ AK + ++L +FNLSV VT+ F+ AV + + L+NP+ GK+V ++ A E+FD + K Sbjct 192 FIYAKKDK-TKLTNFNLSVAVTEKFMEAVIKGEDYPLINPKDGKVVKKLNAKEVFDQMVK 250 Query 344 AAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGR 403 A GGDPG+VF+D IN+ NP P G IE+TNPCGE PLLPYESCNLGSINL + + + + Sbjct 251 LAWEGGDPGIVFIDRINKDNPTPKEGEIESTNPCGEQPLLPYESCNLGSINLGKFVKNKK 310 Query 404 VDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYD 463 + WD L++V AV FLD+VID++ YP P++ E + RKIGLGVMG A+++A L IPY+ Sbjct 311 ILWDELKKVIHTAVHFLDNVIDMNNYPIPQIEEMTKKNRKIGLGVMGWADMMALLEIPYN 370 Query 464 SEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPR--RNAQVTSVAPT 521 SE+A++LA ++M IQ+ AS +LAE+RG+FP F DS + G + RNA VT++APT Sbjct 371 SEDALKLAEKVMSFIQEEGRNASVKLAEKRGSFPNFKDSIYPEKGFKMLRNATVTTIAPT 430 Query 522 GTISLIAGTTAGIEPMFAIAFTRAIVGR-HLLEVNPCFDRLARDRGFYRDELIAEIAQRG 580 GTIS+IAG ++GIEP FAIAF R ++ L+EVNP F +A+ GFY DEL+ +IA+ G Sbjct 431 GTISIIAGASSGIEPYFAIAFYRNVLDNDKLVEVNPIFKEIAKREGFYSDELMEKIAESG 490 Query 581 GVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAI 640 + +P + + F TA EI+P WH++MQAA QR+ + AVSKTVN P ATV+DVR + Sbjct 491 HLEDIDEVPEKWKRVFVTAHEISPIWHVKMQAAFQRYTDNAVSKTVNFPNEATVEDVREV 550 Query 641 YVAAWKAKVKGITVYRYGSREGQVLS 666 Y+ A+K KGIT+YR GSREGQV++ Sbjct 551 YLLAYKEGCKGITIYRDGSREGQVIN 576 >gi|255514004|gb|EET90268.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Candidatus Micrarchaeum acidiphilum ARMAN-2] Length=762 Score = 597 bits (1540), Expect = 2e-168, Method: Compositional matrix adjust. Identities = 319/699 (46%), Positives = 446/699 (64%), Gaps = 32/699 (4%) Query 9 VRRRDGTLVPFDIARIEAAVTRAAREVACDD----------PDMPGTVAKAVADALGRGI 58 V +RD + V FD +IE AV +A + V + + + K + +A G+ Sbjct 5 VIKRDDSKVDFDRTKIENAVFKAYKSVYDSNVKEAELRKRAENSTTDIVKEI-EATGKKE 63 Query 59 APVEDIQDCVEARLGEAGLDD--VARVYIIYRQRRAELRTAKALLGVRDE-LKLSLAAVT 115 VE+IQD VE L L D VA+ YI+YR ++AE+R +A LG+ D+ LKL + + Sbjct 64 IRVEEIQDIVEKVLM---LKDQTVAKSYILYRHKKAEIRAFRASLGIPDDGLKLPINTLI 120 Query 116 VLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWA--ERFATLLRNLEF 173 VL RYLL G+ AES +L R + +AAAE ++ A F + N +F Sbjct 121 VLASRYLLKGPDGKIAESPKQLFTRVSHYIAAAEKKFGKSDDETNALEMEFYDAITNFKF 180 Query 174 LPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAG 233 +PNSPTLMN+GT LG L+ CFVLP+ DS+ IF + AA + ++GGGTG++FS LRP Sbjct 181 MPNSPTLMNAGTKLGQLSACFVLPVGDSIVEIFDAVKYAAIIHQSGGGTGFSFSRLRPTN 240 Query 234 DRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPS 293 D V STGG ASGPVSF++++D A V GG+RRGA M +L V HP I DF+ AK E+ Sbjct 241 DMVKSTGGVASGPVSFMKVFDIATEQVKQGGKRRGANMGILRVDHPSILDFIVAK-ENEG 299 Query 294 ELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGL 353 L +FN+SV +TD F++A+E N + LVNPR GK+V ++ A +++ I A GDPGL Sbjct 300 TLRNFNISVAITDEFMKALEANRDYSLVNPRNGKVVGKLNARAVWNLIITMAWKTGDPGL 359 Query 354 VFLDTINR--ANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA--DGR--VDWD 407 VFLD IN +NPVP G +E+TNPCGE PL PY+SCNLGSIN+A+ML DG+ +DWD Sbjct 360 VFLDRINSSYSNPVPTLGPVESTNPCGEQPLYPYDSCNLGSINMAKMLKKNDGQYDIDWD 419 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 L+ + + VRFLD+VI+ + YP E+ + + R+IGLG+MG A++L LGI YDS EA Sbjct 420 ELKRITRMGVRFLDNVIESNTYPLKEIEDVTKKIRRIGLGIMGWADMLIKLGIRYDSNEA 479 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG--PRRNAQVTSVAPTGTIS 525 + LA ++M I + A S LAEERG FPAF DS + + G P RN+ VT++APTGTIS Sbjct 480 LMLAEKVMSFITENARKMSEELAEERGPFPAFKDSIWYKLGYKPLRNSTVTTIAPTGTIS 539 Query 526 LIA-GTTAGIEPMFAIAFTRAI---VGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGG 581 +IA G + GIEP+F++ + R + +G +L+EVN F+ +A + FY DEL+ ++A R Sbjct 540 IIAGGASQGIEPIFSVVYMRNVHESLGSNLIEVNNEFEAMAIENNFYSDELMKKLAGRVS 599 Query 582 VRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIY 641 ++ +P E+R F TA +IAP+WH+RMQAA Q++V+ AVSKT+N P+ AT D+ Y Sbjct 600 IQDVEEIPQEIRRLFVTAYDIAPEWHVRMQAAFQKYVDNAVSKTINFPSWATPQDIEKAY 659 Query 642 VAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTE 680 V A+K KGITVYR S+ QVL + L + ++ Sbjct 660 VLAYKLGCKGITVYRDSSKSVQVLQSVEQQKTLTEPSSK 698 >gi|95930217|ref|ZP_01312955.1| ribonucleotide reductase large subunit [Desulfuromonas acetoxidans DSM 684] gi|95133680|gb|EAT15341.1| ribonucleotide reductase large subunit [Desulfuromonas acetoxidans DSM 684] Length=738 Score = 595 bits (1535), Expect = 6e-168, Method: Compositional matrix adjust. Identities = 281/564 (50%), Positives = 401/564 (72%), Gaps = 5/564 (0%) Query 107 LKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEP-GSSRRWAERFA 165 L L+ A+TVL RYL DE+GR E+ + +R A +A AE +++ +++ A F Sbjct 10 LPLTNNALTVLERRYLKRDEKGRALETPANMFERVANAIAEAEKKFDKKADTKKVAAEFY 69 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 ++ NLEFLPNSPTLMN+G +LG L+ CFVLP+ DS++SIF + A + ++GGGTG++ Sbjct 70 DMITNLEFLPNSPTLMNAGRELGQLSACFVLPVADSMESIFEAIKNTALIHKSGGGTGFS 129 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS +RPA D V ST G +SGP+SF++++D+A + GG RRGA M +L V HPDI DF+ Sbjct 130 FSRIRPANDVVLSTKGVSSGPLSFMKVFDAATETIKQGGTRRGANMGILRVDHPDIMDFI 189 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 K + + L +FN+SVG+T+ F+ AV+ +G + ++NPRTG++ +M AA++FD I A Sbjct 190 MCKRDQ-TVLTNFNISVGLTEEFMEAVKTDGEYDIINPRTGEVCDKMSAAKVFDHIVDLA 248 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVD 405 G+PG++FLD +NR NP P G IE+TNPCGE PLLPYESCNLGSINL RM+ DG+VD Sbjct 249 WNNGEPGIIFLDRLNRDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLNRMVKDGQVD 308 Query 406 WDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSE 465 WD+L + +VRFLD+VI+V+ YP PE+ E + A RKIGLG+MG A++L +GI Y + Sbjct 309 WDKLRKTVQKSVRFLDNVIEVNNYPIPEITEMSLANRKIGLGIMGWADMLIRVGISYCDQ 368 Query 466 EAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRF-ARSGPR-RNAQVTSVAPTGT 523 EA LA +LM+ I AH ASR LA+ERGAFP F S F R P+ RNA T++APTGT Sbjct 369 EAAELAAKLMKFINDEAHQASRDLAKERGAFPNFEGSIFEQRQEPKIRNATCTTIAPTGT 428 Query 524 ISLIAGTTAGIEPMFAIAFTRAIVGRHLL-EVNPCFDRLARDRGFYRDELIAEIAQRGGV 582 IS+IA +++GIEP+FA+++ R ++ +L EVNP F+ +A++RGFY EL+ IA++G + Sbjct 429 ISIIANSSSGIEPLFAVSYVRQVMDNDILVEVNPLFEEVAKERGFYSPELMKLIAEKGTI 488 Query 583 RGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYV 642 + + ++P +VR F TA +I P+ H+RMQ+A Q++ + AVSKTVN +A DDV +Y Sbjct 489 QDFDQIPEDVRRVFVTAHDITPEEHIRMQSAFQKYTDNAVSKTVNFCNSANRDDVAQVYQ 548 Query 643 AAWKAKVKGITVYRYGSREGQVLS 666 A+++ KG+T+YR GSR+ QVLS Sbjct 549 MAYESGCKGVTIYRDGSRDAQVLS 572 >gi|333986799|ref|YP_004519406.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanobacterium sp. SWAN-1] gi|333824943|gb|AEG17605.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Methanobacterium sp. SWAN-1] Length=606 Score = 594 bits (1532), Expect = 2e-167, Method: Compositional matrix adjust. Identities = 283/603 (47%), Positives = 397/603 (66%), Gaps = 10/603 (1%) Query 97 AKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGS 156 ++ L +D+L++SL A +L+++YL+ D G E+ EL R AR +A + Y+ + Sbjct 3 SEDLSNFKDDLEISLNARKILQKKYLIRDVDGNITETPSELFRRVAREIAKIDRLYDHDA 62 Query 157 S-RRWAERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAEL 215 + E F ++ EFLPNSPTLMN+GT + L+ CFVLP+ DS+ IF L A + Sbjct 63 DVEKTEEEFFNVMSCFEFLPNSPTLMNAGTSINQLSACFVLPVGDSMGEIFDALKYMALI 122 Query 216 QRAGGGTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLD 275 ++GGG G++FS LRP GD V ST G ASGP+SF+R++D A VV GG+RRGA M +L+ Sbjct 123 HKSGGGVGFSFSDLRPQGDIVKSTKGIASGPLSFMRIFDVATDVVKQGGKRRGANMGILN 182 Query 276 VSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAA 335 + HPDI +F+ AK E L +FNLSV V D F++ VE + + L+NPR + V R+ A Sbjct 183 IKHPDILEFIAAK-EQEGFLSNFNLSVAVDDEFMQKVEDDEEYELINPRNNEAVTRLRAL 241 Query 336 ELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINL 395 E+F+++ + A GDPG++FLD INR NP G G+IEATNPCGE PLLPYESCNLGSINL Sbjct 242 EVFNSVVEKAWKSGDPGIIFLDEINRKNPTKGAGKIEATNPCGEQPLLPYESCNLGSINL 301 Query 396 ARMLADGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELL 455 +M+ +G+++WD+L + AV FLD+VID + +P ++ RKIGLG+MG AE+L Sbjct 302 VKMVKNGKINWDKLRNIIRTAVHFLDNVIDANNFPIHQIEVQTLKNRKIGLGIMGFAEML 361 Query 456 AALGIPYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDS--RFARSGPRRNA 513 L +PYDS+EA+++A LM I+ + S L RG+FP F S F G RNA Sbjct 362 IMLNVPYDSQEAIKIAEELMSFIETTSRGVSAELGRLRGSFPDFNGSIWDFKGYGAMRNA 421 Query 514 QVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDEL 572 +T++APTGT+S+IA T+ IEP+FA++F R ++ G L+EVNP F+++A+D GFY EL Sbjct 422 TITTIAPTGTLSIIANVTSSIEPLFAVSFIRKVMEGTELIEVNPLFEKIAKDEGFYSTEL 481 Query 573 IAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATA 632 + I +RG ++ +P + R F TA +I PQWH+RMQAA QRHV+ AVSKTVNLP A Sbjct 482 MMSIVKRGSIQDILDIPEDTRRLFVTAHDIDPQWHVRMQAAFQRHVDNAVSKTVNLPHAA 541 Query 633 TVDDVRAIYVAAWKAKVKGITVYRYGSREGQVL-----SYAAPKPLLAQADTEFSGGCAG 687 +++DV+ +++ A K K KGITVYRY S++ QVL S D E++GGC Sbjct 542 SINDVKKVFLLAHKLKCKGITVYRYASKKKQVLYINKDSQDGNGEKYFCVDLEYAGGCPK 601 Query 688 RSC 690 C Sbjct 602 IHC 604 >gi|254168705|ref|ZP_04875547.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|197622331|gb|EDY34904.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] Length=796 Score = 591 bits (1524), Expect = 1e-166, Method: Compositional matrix adjust. Identities = 311/722 (44%), Positives = 446/722 (62%), Gaps = 64/722 (8%) Query 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP---VEDI 64 KV +RDG +V F +I A+ +A + + V + V + + VE I Sbjct 20 KVIKRDGRIVDFSEDKIFQAIMKAMNSIGGYGEEDAQRVTRKVVEKIKESRVERITVEKI 79 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYL-- 122 QD VE L G +VA+ YI+YR+ R ++R AK ++GV+D+LKL++ A+ VL RYL Sbjct 80 QDIVEETLMLEGYINVAKSYILYREERRKIRQAKKVIGVQDDLKLTVNAIKVLEARYLLK 139 Query 123 -------------------------------LHDEQGRPAESTGELMDR----------- 140 ++D++G+ E ++ ++ Sbjct 140 DENGNVIETPRQMFERTARYLALVDIFYEDDIYDKEGKQKERKIDVEEKPEFLSIWEFNM 199 Query 141 --------SARCVAAAEDQYEPGSSR-RW------AERFATLLRNLEFLPNSPTLMNSGT 185 S + Y S + +W +FA ++ + +++PNSPTLMN+ T Sbjct 200 LKRAFTYFSKEGYMKVDFSYVLDSLKSKWDKIERVKNKFAEVMLHRKYVPNSPTLMNANT 259 Query 186 DLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASG 245 LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++FS LRP GD VAST G ASG Sbjct 260 KLGQLSACFVLPVPDSIEGIFNAVKYAAMIHKSGGGTGFSFSRLRPKGDIVASTMGVASG 319 Query 246 PVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVT 305 P+SF+R++D A V+ GG+RRGA M VL V HPDI +F+T+K L +FN+SV VT Sbjct 320 PLSFMRVFDVATDVIKQGGKRRGANMGVLSVHHPDILEFITSKDSENKVLSNFNISVAVT 379 Query 306 DAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPV 365 D F+ A+ R+ + L NPR G+ V R+ A +++D I A GDPG++F+D +NR +PV Sbjct 380 DEFMDALLRDDYYPLRNPRNGEEVKRIKARQVWDLIITQAWKTGDPGVIFIDEVNRKHPV 439 Query 366 PGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVID 425 G IE+TNPCGE PLLPYESCNLGSINL+ + +G++ WD L + AV F+D+VID Sbjct 440 KHLGEIESTNPCGEQPLLPYESCNLGSINLSLFVENGKIKWDDLRDTVHTAVHFMDNVID 499 Query 426 VSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTA 485 + YP P++ E R +RKIGLGVMG AE+L LGIPYDSEEAV LA ++M+ I + +H A Sbjct 500 ANNYPLPQVAEMTRRSRKIGLGVMGWAEMLIKLGIPYDSEEAVELAEKVMKFINEESHRA 559 Query 486 SRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 S +LAE+RG FPA+ S + + G + RNA T++APTGTIS+IAGT++ IEP+FAIAF R Sbjct 560 SMKLAEKRGVFPAWEGSEWWKKGMKIRNATTTTIAPTGTISIIAGTSSSIEPLFAIAFIR 619 Query 545 AIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIA 603 ++ G+ LLEVNP F+ + + G Y +EL+ ++A+ G V+ +P ++ F TA +I Sbjct 620 RVLDGQELLEVNPLFEEIMKREGLYSEELMHKVAETGSVQHIDDVPENIKRLFRTAHDID 679 Query 604 PQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQ 663 P WH+RMQAA Q++V+ AVSKTVNL A++ DV Y+ AWK K KGIT+YR GS+ Q Sbjct 680 PVWHVRMQAAFQKYVDNAVSKTVNLRHDASISDVEDTYILAWKLKCKGITIYRDGSKNVQ 739 Query 664 VL 665 V+ Sbjct 740 VI 741 >gi|289596835|ref|YP_003483531.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|289534622|gb|ADD08969.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] Length=785 Score = 591 bits (1524), Expect = 1e-166, Method: Compositional matrix adjust. Identities = 311/722 (44%), Positives = 446/722 (62%), Gaps = 64/722 (8%) Query 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP---VEDI 64 KV +RDG +V F +I A+ +A + + V + V + + VE I Sbjct 9 KVIKRDGRIVDFSEDKIFQAIMKAMNSIGGYGEEDAQRVTRKVVEKIKESRVERITVEKI 68 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYL-- 122 QD VE L G +VA+ YI+YR+ R ++R AK ++GV+D+LKL++ A+ VL RYL Sbjct 69 QDIVEETLMLEGYINVAKSYILYREERRKIRQAKKVIGVQDDLKLTVNAIKVLEARYLLK 128 Query 123 -------------------------------LHDEQGRPAESTGELMDR----------- 140 ++D++G+ E ++ ++ Sbjct 129 DENGNVIETPRQMFERTARYLALVDIFYEDDIYDKEGKQKERKIDVEEKPEFLSIWEFNM 188 Query 141 --------SARCVAAAEDQYEPGSSR-RW------AERFATLLRNLEFLPNSPTLMNSGT 185 S + Y S + +W +FA ++ + +++PNSPTLMN+ T Sbjct 189 LKRAFTYFSKEGYMKVDFSYVLDSLKSKWDKIERVKNKFAEVMLHRKYVPNSPTLMNANT 248 Query 186 DLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASG 245 LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++FS LRP GD VAST G ASG Sbjct 249 KLGQLSACFVLPVPDSIEGIFNAVKYAAMIHKSGGGTGFSFSRLRPKGDIVASTMGVASG 308 Query 246 PVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVT 305 P+SF+R++D A V+ GG+RRGA M VL V HPDI +F+T+K L +FN+SV VT Sbjct 309 PLSFMRVFDVATDVIKQGGKRRGANMGVLSVHHPDILEFITSKDSENKVLSNFNISVAVT 368 Query 306 DAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPV 365 D F+ A+ R+ + L NPR G+ V R+ A +++D I A GDPG++F+D +NR +PV Sbjct 369 DEFMDALLRDDYYPLRNPRNGEEVKRIKARQVWDLIITQAWKTGDPGVIFIDEVNRKHPV 428 Query 366 PGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVID 425 G IE+TNPCGE PLLPYESCNLGSINL+ + +G++ WD L + AV F+D+VID Sbjct 429 KHLGEIESTNPCGEQPLLPYESCNLGSINLSLFVENGKIKWDDLRDTVHTAVHFMDNVID 488 Query 426 VSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTA 485 + YP P++ E R +RKIGLGVMG AE+L LGIPYDSEEAV LA ++M+ I + +H A Sbjct 489 ANNYPLPQVAEMTRRSRKIGLGVMGWAEMLIKLGIPYDSEEAVELAEKVMKFINEESHRA 548 Query 486 SRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 S +LAE+RG FPA+ S + + G + RNA T++APTGTIS+IAGT++ IEP+FAIAF R Sbjct 549 SMKLAEKRGVFPAWEGSEWWKKGMKIRNATTTTIAPTGTISIIAGTSSSIEPLFAIAFIR 608 Query 545 AIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIA 603 ++ G+ LLEVNP F+ + + G Y +EL+ ++A+ G V+ +P ++ F TA +I Sbjct 609 RVLDGQELLEVNPLFEEIMKREGLYSEELMHKVAETGSVQHIDDVPENIKRLFRTAHDID 668 Query 604 PQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQ 663 P WH+RMQAA Q++V+ AVSKTVNL A++ DV Y+ AWK K KGIT+YR GS+ Q Sbjct 669 PVWHVRMQAAFQKYVDNAVSKTVNLRHDASISDVEDTYILAWKLKCKGITIYRDGSKNVQ 728 Query 664 VL 665 V+ Sbjct 729 VI 730 >gi|319789960|ref|YP_004151593.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermovibrio ammonificans HB-1] gi|317114462|gb|ADU96952.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermovibrio ammonificans HB-1] Length=568 Score = 590 bits (1521), Expect = 3e-166, Method: Compositional matrix adjust. Identities = 289/572 (51%), Positives = 398/572 (70%), Gaps = 14/572 (2%) Query 107 LKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGS-SRRWAERFA 165 +KLS A+ +L+ RYL RP E+ EL +R AR V+ AE Y P S + RW E F Sbjct 2 VKLSETAIEILKARYL------RPGETPQELFERVARAVSEAELLYGPASQAARWEEEFL 55 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 ++ NLEFLPNSPTLMN+GT LG LA CFVLP+EDS++ IFA++ A++Q+ GGGTG++ Sbjct 56 KVMENLEFLPNSPTLMNAGTPLGQLAACFVLPVEDSIEEIFASVSLMAKIQKTGGGTGFS 115 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS LRP GD V ST G ASGPVSF+++++ A + GG+RRGA M VL V+HPD+ +F+ Sbjct 116 FSRLRPKGDTVKSTNGKASGPVSFMKVFNCATDAIKQGGKRRGANMGVLSVNHPDVKEFI 175 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 T K + S +FN+SV TD F + + G L+NPR GK+ +R+ A EL D I ++A Sbjct 176 TCKTDGKS-FQNFNISVACTDDFFQKALKGGEIELINPRDGKVWSRVKADELLDLIAESA 234 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVD 405 GDPG++++D INR NP P GRIEATNPCGEVPLLPYE CNLGSINL++++ GR++ Sbjct 235 WKTGDPGILYIDEINRHNPTPALGRIEATNPCGEVPLLPYEECNLGSINLSKIVEKGRIN 294 Query 406 WDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSE 465 W++LE + VAVRFLD VIDV+RYP PE+ + A+ RKIGLGVMG AELL L IPYDSE Sbjct 295 WEKLERLVKVAVRFLDCVIDVNRYPHPEIEKMAKGNRKIGLGVMGWAELLIELEIPYDSE 354 Query 466 EAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTIS 525 EAV LA RLM I + A AS LA+++G+FP S + R RNA TS+APTGTIS Sbjct 355 EAVELAERLMGFINRKAFEASAELAKQKGSFPNIDKSVY-RGKTLRNATRTSIAPTGTIS 413 Query 526 LIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IAGTT IEP+FA+ + + ++ GR + + P + ++ + + EI + G ++ Sbjct 414 MIAGTTPSIEPLFAVGYVKRVLGGRRVPFIEPLLMKKVKELSLQQ---LKEILESGTLQR 470 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 +P +++ F TA EIAP+WHL++QAA Q+H + AVSKTVNLP +AT +D++ I++ Sbjct 471 AEGIPEKIKRIFKTAHEIAPEWHLKIQAAFQKHTDNAVSKTVNLPKSATPEDIKEIFITG 530 Query 645 WKAKVKGITVYRYGSREGQVLSYAAPKPLLAQ 676 +K K+KG+TV+R GS+EG V+ + + LL++ Sbjct 531 YKLKLKGVTVFREGSKEG-VVEFKVDQELLSE 561 >gi|327401108|ref|YP_004341947.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Archaeoglobus veneficus SNP6] gi|327316616|gb|AEA47232.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Archaeoglobus veneficus SNP6] Length=749 Score = 588 bits (1516), Expect = 1e-165, Method: Compositional matrix adjust. Identities = 288/563 (52%), Positives = 401/563 (72%), Gaps = 5/563 (0%) Query 107 LKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFAT 166 ++L+ A VL++RYLL DE+G E+ +++ R A +A E++Y G + A++F Sbjct 1 MELTKTAEVVLKKRYLLKDEEGNVIETPEQMLWRVANAIAQPEEKY-GGDVEKTAKQFFE 59 Query 167 LLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAF 226 ++ N F+PNSPTLMN+GT+L L+ CFV+P++DS+ IF L A++Q++GGGTG++F Sbjct 60 MMDNQLFMPNSPTLMNAGTELNQLSACFVIPVDDSIDGIFKALWDMAKVQKSGGGTGFSF 119 Query 227 SHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVT 286 S LRP GD V ST G ASGPVSF++++D+A + GG+RRGA M VL+V HPDI DF+T Sbjct 120 SRLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGKRRGANMGVLNVHHPDIEDFIT 179 Query 287 AKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAH 346 AK E L +FN+SV VTDAF+ A++ + + +NPRTG++V ++PA ++F+ I + A Sbjct 180 AKWEE-GVLRNFNISVAVTDAFMEALKNDAEYEQINPRTGEVVRKVPARKIFNLIVEGAW 238 Query 347 AGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDW 406 G+PG+VF+DTINR NP P G IEATNPCGE PLLPYESCNLGSIN+++ + +G +DW Sbjct 239 RNGEPGVVFIDTINRHNPTPHIGMIEATNPCGEQPLLPYESCNLGSINVSKFVKNGDIDW 298 Query 407 DRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEE 466 D L E+ +AVRFLD+VIDV+ YP PE+ + A RKIGLGVMG A+LL L IPYDSEE Sbjct 299 DWLREIVWLAVRFLDNVIDVNNYPLPEIEKMTLANRKIGLGVMGFADLLFKLKIPYDSEE 358 Query 467 AVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTIS 525 + LA +LM IQ+ +H AS+ LAEERG FP + S + + G + RNA T++APTGTIS Sbjct 359 GIALAEKLMSFIQEESHKASQALAEERGVFPNWKGSTWEKKGIKMRNATTTTIAPTGTIS 418 Query 526 LIAGTTAGIEPMFAIAFTRAIV--GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVR 583 +IAG ++GIEP++A+AF R + G E+NP F+ R G Y DELIA++A+ G ++ Sbjct 419 IIAGCSSGIEPVYALAFKRMHILDGEEFFEINPIFEDTLRQLGLYSDELIAKVAEEGSIQ 478 Query 584 GYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVA 643 P +P E++ F A +IAP+WH+RMQAA Q++ + AVSKT+N+P AT DV ++ Sbjct 479 DIPEIPKEIKRIFKCALDIAPEWHVRMQAAFQKYTDNAVSKTINMPNHATRKDVEKAFLL 538 Query 644 AWKAKVKGITVYRYGSREGQVLS 666 A++ KGITVYR GSRE QVL Sbjct 539 AYELGCKGITVYRDGSREEQVLK 561 >gi|254168812|ref|ZP_04875653.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] gi|197622249|gb|EDY34823.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Aciduliprofundum boonei T469] Length=796 Score = 588 bits (1516), Expect = 1e-165, Method: Compositional matrix adjust. Identities = 309/722 (43%), Positives = 444/722 (62%), Gaps = 64/722 (8%) Query 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP---VEDI 64 KV +RD +V F +I A+ +A + + V V + + VE I Sbjct 20 KVIKRDSRIVDFSEDKIFQAIMKAMNSIGGYSEEDAQRVTWKVVEKIKESRVERITVEKI 79 Query 65 QDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYL-- 122 QD VE L G +VA+ YI+YR+ R ++R AK ++GV+D+LKL++ A+ VL RYL Sbjct 80 QDIVEETLMLEGYINVAKSYILYREERRKIRQAKKVIGVQDDLKLTVNAIKVLEARYLLK 139 Query 123 -------------------------------LHDEQGRPAESTGELMDR----------- 140 ++D++G+ E ++ ++ Sbjct 140 DENGNVIETPRQMFERTARYLALVDIFYEDDIYDKEGKQKERKIDVEEKPEFLSIWEFNM 199 Query 141 --------SARCVAAAEDQYEPGSSR-RW------AERFATLLRNLEFLPNSPTLMNSGT 185 S + Y S + +W +FA ++ + +++PNSPTLMN+ T Sbjct 200 LKRAFTYFSKEGYMKVDFSYVLDSLKSKWDKIERVKNKFAEVMLHRKYVPNSPTLMNANT 259 Query 186 DLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASG 245 LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++FS LRP GD VAST G ASG Sbjct 260 KLGQLSACFVLPVPDSIEGIFNAVKYAAMIHKSGGGTGFSFSRLRPKGDIVASTMGVASG 319 Query 246 PVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVT 305 P+SF+R++D A V+ GG+RRGA M VL V HPDI +F+T+K L +FN+SV VT Sbjct 320 PLSFMRVFDVATDVIKQGGKRRGANMGVLSVHHPDILEFITSKDSENKVLSNFNISVAVT 379 Query 306 DAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPV 365 D F+ A+ R+ + L NPR G+ V ++ A +++D I A GDPG++F+D +NR +PV Sbjct 380 DEFMEALLRDDYYPLRNPRNGEEVKKIKARQVWDLIITQAWKTGDPGIIFIDEVNRRHPV 439 Query 366 PGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVID 425 G IE+TNPCGE PLLPYESCNLGSINL+ + +G++ WD L + AV F+D+VID Sbjct 440 KHLGEIESTNPCGEQPLLPYESCNLGSINLSLFVENGKIKWDDLRDTVHTAVHFMDNVID 499 Query 426 VSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTA 485 + YP P++ E R +RKIGLGVMG AE+L LGIPYDSEEAV LA ++M+ I + +H A Sbjct 500 ANNYPLPQVAEMTRRSRKIGLGVMGWAEMLIKLGIPYDSEEAVELAEKVMKFINEESHRA 559 Query 486 SRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 S +LAE+RG FPA+ S + + G + RNA T++APTGTIS+IAGT++ IEP+FAIAF R Sbjct 560 SMKLAEKRGVFPAWEGSEWWKKGMKIRNATTTTIAPTGTISIIAGTSSSIEPLFAIAFIR 619 Query 545 AIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIA 603 ++ G+ LLEVNP F+ + + G Y +EL+ ++A+ G V+ +P ++ F TA +I Sbjct 620 RVLDGQELLEVNPLFEEIMKREGLYSEELMHKVAETGSVQHIDDVPENIKRLFRTAHDID 679 Query 604 PQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQ 663 P WH+RMQAA Q++V+ AVSKTVNL A++ DV Y+ AWK K KGIT+YR GS+ Q Sbjct 680 PVWHVRMQAAFQKYVDNAVSKTVNLRHDASISDVEDTYILAWKLKCKGITIYRDGSKNVQ 739 Query 664 VL 665 V+ Sbjct 740 VI 741 >gi|220933052|ref|YP_002509960.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Halothermothrix orenii H 168] gi|219994362|gb|ACL70965.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Halothermothrix orenii H 168] Length=766 Score = 587 bits (1513), Expect = 3e-165, Method: Compositional matrix adjust. Identities = 278/570 (49%), Positives = 398/570 (70%), Gaps = 8/570 (1%) Query 106 ELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFA 165 ++KL+ A+ VL+ RYL D G E+ E+ R A +A+A ++Y R E F Sbjct 3 DIKLTRNAIKVLKARYLKRDASGELIETPEEMFKRVANNIASANEKYGEDPERD-KEAFF 61 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 L+ +L+FLPNSPTLMN+ DL L+ CFVLPIEDS+ IF L A +Q++GGGTG++ Sbjct 62 NLMASLDFLPNSPTLMNADNDLQQLSACFVLPIEDSMDGIFDALKYTALIQKSGGGTGFS 121 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS LRP D V +TGG ASGP+SF+ ++D+A V GG+RRGA M +L V HPDI +F+ Sbjct 122 FSRLRPKSDIVKTTGGVASGPISFMEIFDAATNTVKQGGKRRGANMGILRVDHPDIMEFI 181 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 TAKA+ + L +FN+SV VTD F+ AV+++ + LVNPR+G++V ++ A E+F+ I + A Sbjct 182 TAKADE-NRLNNFNISVAVTDEFMEAVKKDEEYDLVNPRSGQVVGQLRAREVFNKIVEMA 240 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADG--- 402 H G+PG++F+D INR NP P G IE+TNPCGE PLLPYE+CNLGSINL+ M+ + Sbjct 241 HKNGEPGIIFIDEINRHNPTPHLGEIESTNPCGEQPLLPYEACNLGSINLSHMVKNEGDK 300 Query 403 -RVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIP 461 VD+++LE A RFLD+VID++RYP ++ E + RKIGLGVMG ++LL LGIP Sbjct 301 PEVDFEKLENTVRTATRFLDNVIDMNRYPLEQIKEMVYSNRKIGLGVMGWSDLLIRLGIP 360 Query 462 YDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPT 521 Y+S+ AV LA ++M+ I + +H S ++A +RG+FP S + +S RNA T++APT Sbjct 361 YNSDRAVNLAEKVMKFINEISHDESHKIARKRGSFPNIEGSIYDKS--MRNATTTTIAPT 418 Query 522 GTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGG 581 G+IS+IAG ++GIEP+FAI + R ++ L+EV+P F+++AR+RGFY +EL+A++A+RG Sbjct 419 GSISIIAGCSSGIEPLFAINYERHVLDDTLIEVHPYFEKIARERGFYSEELMAKVAERGS 478 Query 582 VRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIY 641 ++G +P +V+ F TA +I P+WH++MQAA Q+ V+ AVSKTVN AT +DV +Y Sbjct 479 IQGMSEIPEDVQKIFVTAHDIEPEWHIKMQAAFQKWVDNAVSKTVNFRHEATKEDVARVY 538 Query 642 VAAWKAKVKGITVYRYGSREGQVLSYAAPK 671 A+ K KG+T+YR GSR QVL+ K Sbjct 539 TLAYDLKCKGVTIYRDGSRSEQVLATGRSK 568 >gi|39996969|ref|NP_952920.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter sulfurreducens PCA] gi|39983857|gb|AAR35247.1| ribonucleoside-diphosphate reductase, putative [Geobacter sulfurreducens PCA] gi|298505986|gb|ADI84709.1| ribonucleoside diphosphate reductase, adenosylcobalamin-dependent [Geobacter sulfurreducens KN400] Length=743 Score = 586 bits (1510), Expect = 6e-165, Method: Compositional matrix adjust. Identities = 280/562 (50%), Positives = 392/562 (70%), Gaps = 5/562 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 LS AVTVL +RYL D G E+ ++ R AR +A A+ ++ + + A +F L Sbjct 14 LSKNAVTVLEKRYLKRDTGGNVLETPVDMFQRVARSIAEADKNFDKKADVKALAAQFYEL 73 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + + EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF + A + ++GGGTG++FS Sbjct 74 MTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKYTALIHKSGGGTGFSFS 133 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D+A + GG RRGA M +L V HPDI DF+ Sbjct 134 RLRPAHDVVRSTSGISSGPISFMRVFDAATETIKQGGTRRGANMGILRVDHPDIMDFIMC 193 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 K + L +FN+SVG+T+AF+ AVER+ + L+NPR GK + A ++F I K A Sbjct 194 K-DDQKHLNNFNISVGLTEAFMEAVERDADYDLINPRDGKPCGTLNARKVFSRIVKQAWK 252 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +N+ NP P G IE+TNPCGE PLLPYESCNLGSINL +M+ +G V+WD Sbjct 253 NGEPGIIFLDRLNKDNPTPHVGVIESTNPCGEQPLLPYESCNLGSINLGKMVKNGDVNWD 312 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 RL +V +AV FLD+VI+V+ YP P++ E RA RKIGLGVMG A++L LGIPY+S +A Sbjct 313 RLRDVVRLAVHFLDNVIEVNNYPLPQISEMTRANRKIGLGVMGWADMLILLGIPYNSPQA 372 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARS--GPRRNAQVTSVAPTGTIS 525 + L ++MR I H SR LA RG+FP F S + R+ GP RNA VT++APTGTIS Sbjct 373 ISLGEKVMRFINDEGHVYSRELAAVRGSFPNFAGSIYDRASEGPIRNATVTTIAPTGTIS 432 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRHLL-EVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA++F R ++ +++L EVNP F+ +AR RGFY +EL+ +IA+ G + Sbjct 433 IIANASSGVEPLFAVSFIRQVLDKNILVEVNPIFEEVARQRGFYSEELMQKIARHGTIHD 492 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 P +P ++R F TA +I P+ H+ MQAA Q++ + AVSKTVN P +A ++DV +Y A Sbjct 493 LPEIPEDIRKIFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNSAAIEDVEKVYRLA 552 Query 645 WKAKVKGITVYRYGSREGQVLS 666 +K+ KG+T+YR GSR+ QVLS Sbjct 553 YKSGCKGVTIYRDGSRDEQVLS 574 >gi|78222511|ref|YP_384258.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter metallireducens GS-15] gi|78193766|gb|ABB31533.1| Ribonucleotide reductase large subunit [Geobacter metallireducens GS-15] Length=742 Score = 585 bits (1509), Expect = 7e-165, Method: Compositional matrix adjust. Identities = 284/576 (50%), Positives = 391/576 (68%), Gaps = 5/576 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEP-GSSRRWAERFATL 167 LS A TVL +RYL D GR E+ ++ R A +A A+ ++ ++ A++F L Sbjct 13 LSKNARTVLEKRYLKRDTDGRVLETPADMFRRVAEAIAVADRNFDKKADTKALAQKFYDL 72 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + + EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF + A + ++GGGTG++FS Sbjct 73 MTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFS 132 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D+A + GG RRGA M +L V HPDI DF+ Sbjct 133 RLRPANDVVRSTSGISSGPISFMRVFDAATETIKQGGTRRGANMGILRVDHPDIMDFIMC 192 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 K + L +FN+SVG+T+AF+ AVER+ + L NPR GK + A ++F I K A Sbjct 193 K-DDQKHLNNFNISVGLTEAFMEAVERDADYDLRNPRDGKPCGTLNARKVFSRIVKQAWK 251 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +N+ NP P G IE+TNPCGE PLLPYESCNLGSINL +M+ +G VDW Sbjct 252 NGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVNNGDVDWK 311 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 RL EV + V FLD+VI+V+ YP P++ + R+ RKIGLGVMG A++L LGIPY S EA Sbjct 312 RLREVIRLGVHFLDNVIEVNNYPLPQINDMTRSNRKIGLGVMGWADMLILLGIPYSSPEA 371 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFAR--SGPRRNAQVTSVAPTGTIS 525 + L ++MR I H SR LA RGAFP F S F R GP RNA VT++APTGTIS Sbjct 372 ISLGEKVMRFINDEGHAYSRELAAVRGAFPNFVGSTFDRPGEGPIRNATVTTIAPTGTIS 431 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRHLL-EVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA++F R ++ +++L EVNP F+ +ARD+GFY +EL+ +IAQ G V Sbjct 432 IIANASSGVEPLFAVSFVRQVLDKNILVEVNPIFEEIARDQGFYSEELMQKIAQHGTVHD 491 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 +P ++R F TA +I P+ H+ MQAA Q++ + AVSKTVN P AT+++V +Y A Sbjct 492 LAEIPEDIRKVFVTAHDITPEDHIEMQAAFQKYTDNAVSKTVNFPNAATIEEVEKVYRLA 551 Query 645 WKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTE 680 +K + KG+T+YR GSR+ QVLS A + TE Sbjct 552 YKLECKGVTIYRDGSRDEQVLSTGAKEEKEKVVQTE 587 >gi|253701670|ref|YP_003022859.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter sp. M21] gi|251776520|gb|ACT19101.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Geobacter sp. M21] Length=744 Score = 585 bits (1507), Expect = 1e-164, Method: Compositional matrix adjust. Identities = 275/562 (49%), Positives = 395/562 (71%), Gaps = 5/562 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 L+ A+TVL +RYL D+ G+P E+ ++ R A +A A+ ++ + +++F T+ Sbjct 13 LTKNALTVLEKRYLKRDQTGKPLETASDMFRRVATAIAQADAVFDKKADIGALSDKFYTM 72 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + N EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF ++ A + ++GGGTG++FS Sbjct 73 MTNFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFESVKYTALIHKSGGGTGFSFS 132 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D A + GG RRGA MA+L V HPDI DF+ Sbjct 133 RLRPANDVVMSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMAILRVDHPDIMDFIMC 192 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 K++ +L +FN+SVG+T+AF++AV+ + + L NPR + + A ++F+ I K A Sbjct 193 KSDQ-RQLNNFNISVGITEAFMKAVDADEEYTLFNPRDKQPAGKQNARKVFNRIVKQAWE 251 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +N+ NP P G IE+TNPCGE PLLPYESCNLGSINL +M+ G+VDWD Sbjct 252 NGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVIHGKVDWD 311 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 +L+EV +V FLD+VI+V+ YP ++ E R+ RKIGLGVMG A++L LGIPY S E+ Sbjct 312 KLKEVVRTSVHFLDNVIEVNNYPLQQIDEMTRSNRKIGLGVMGWADMLIMLGIPYGSAES 371 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG--PRRNAQVTSVAPTGTIS 525 V L ++M+ I H ASR+LA+ RGAFP F S + + G P RNA VT++APTGTIS Sbjct 372 VELGEKVMQFINDEGHAASRQLAKTRGAFPNFKGSVYDKPGAEPIRNATVTTIAPTGTIS 431 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRHLL-EVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA+++ R ++ +++L EVNP F+++A+ GFY DEL+ IA+ G V+ Sbjct 432 IIANASSGVEPLFAVSYVRQVMDKNILVEVNPLFEKIAKTDGFYTDELMQRIAEHGTVQD 491 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 +P VR F TA +I P+ H+ MQAA QRH + AVSKTVN P AT++DV +Y A Sbjct 492 ISAIPEAVREVFVTAHDITPEEHITMQAAFQRHTDNAVSKTVNFPCEATIEDVEKVYRLA 551 Query 645 WKAKVKGITVYRYGSREGQVLS 666 +++ KG+T+YR GSR+ QVLS Sbjct 552 YESNCKGVTIYRDGSRDEQVLS 573 >gi|197117589|ref|YP_002138016.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter bemidjiensis Bem] gi|197086949|gb|ACH38220.1| ribonucleoside diphosphate reductase, adenosylcobalamin-dependent [Geobacter bemidjiensis Bem] Length=744 Score = 584 bits (1506), Expect = 2e-164, Method: Compositional matrix adjust. Identities = 277/573 (49%), Positives = 398/573 (70%), Gaps = 5/573 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 L+ A+TVL +RYL D+ G+ E+ ++ R A +A A+ ++ + +++F + Sbjct 13 LTKNALTVLEKRYLKRDQTGKTLETASDMFRRVATAIAQADAVFDKKADIGALSDKFYNM 72 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + N EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF ++ A + ++GGGTG++FS Sbjct 73 MTNFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFESVKYTALIHKSGGGTGFSFS 132 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D A + GG RRGA MA+L V HPDI DF+ Sbjct 133 RLRPANDVVMSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMAILRVDHPDIMDFIMC 192 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 KA+ +L +FN+SVG+T+AF++AV+ + + L NPR + + A ++F+ I K A Sbjct 193 KADQ-RQLNNFNISVGITEAFMKAVDADEEYTLYNPRDKQPAGKQNARKVFNRIVKQAWE 251 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +N+ NP P G IE+TNPCGE PLLPYESCNLGSINL +M+ G+VDWD Sbjct 252 NGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVIHGKVDWD 311 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 +L+EV +V FLD+VI+V+ YP ++ E R+ RKIGLGVMG A++L LGIPY SEE+ Sbjct 312 KLKEVVRTSVHFLDNVIEVNNYPLQQIDEMTRSNRKIGLGVMGWADMLIMLGIPYGSEES 371 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG--PRRNAQVTSVAPTGTIS 525 V L ++M+ I H ASR+LA+ RGAFP F S + + G P RNA VT++APTGTIS Sbjct 372 VELGEKVMQFINDEGHAASRQLAKTRGAFPNFKGSVYDKLGAEPIRNATVTTIAPTGTIS 431 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRHLL-EVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA+++ R ++ +++L EVNP F+++A+ GFY DEL+ IA+ G V+ Sbjct 432 IIANASSGVEPLFAVSYVRQVMDKNILVEVNPLFEKIAKTDGFYTDELMQRIAEHGTVQD 491 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 +P VR F TA +I P+ H+ MQAA QRH + AVSKTVN P AT++DV +Y A Sbjct 492 ISAIPEAVREVFVTAHDITPEEHITMQAAFQRHTDNAVSKTVNFPCEATIEDVEKVYRLA 551 Query 645 WKAKVKGITVYRYGSREGQVLSYAAPKPLLAQA 677 +++ KG+T+YR GSR+ QVLS + + A A Sbjct 552 YESNCKGVTIYRDGSRDEQVLSVGKKEEVKAAA 584 >gi|13540923|ref|NP_110611.1| ribonucleotide-diphosphate reductase subunit alpha [Thermoplasma volcanium GSS1] Length=767 Score = 584 bits (1505), Expect = 2e-164, Method: Compositional matrix adjust. Identities = 314/722 (44%), Positives = 433/722 (60%), Gaps = 64/722 (8%) Query 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP-VEDIQD 66 +V +RDGT+VPF+ +I A+ +A V T+A V + L P VE IQD Sbjct 4 EVVKRDGTVVPFEKGKIAMAIYKAMLSVKNGSMRDAETLADKVVERLKNIERPTVEQIQD 63 Query 67 CVEARLGEAGLD-----DVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERY 121 VE L + ++ DVA+ YI+YR++R +R K LGV+D+LKL+L AV VL RY Sbjct 64 IVEDVLMTSKIEGKIFTDVAKSYILYREKRRAIREEKESLGVKDDLKLTLNAVKVLEARY 123 Query 122 LLHDEQGRPAESTGELMDRSARCVAAAEDQY----------------------------- 152 LL DE G+ E+ ++ R A + E Y Sbjct 124 LLKDEDGKIIETPRQMFRRVASHIGIIEALYDFMEYKKTGKIPENAEKIGKVSLTQEEVL 183 Query 153 --------EPGSSRRWAERFATLL------------------RNLEFLPNSPTLMNSGTD 186 E G E F L +L+F+PNSPTLMN+GT Sbjct 184 RRAFNYMKEDGIMEGTFEEFMDFLSTKGTSAHLYINKFEEMMSSLDFVPNSPTLMNAGTK 243 Query 187 LGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGP 246 LG L+ CFVLP+ DS++ IF TL A + ++GGGTG++FS LRP D V ST G ASGP Sbjct 244 LGQLSACFVLPVGDSIEDIFETLKNTALIHKSGGGTGFSFSRLRPKDDIVGSTKGVASGP 303 Query 247 VSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTD 306 VSF++++D V+ GG+RRGA M +L+ +HPDI +FV +K L +FN+SVGVTD Sbjct 304 VSFMKIFDVTTDVIKQGGKRRGANMGILNYNHPDIMEFVLSKDSENKVLSNFNISVGVTD 363 Query 307 AFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVP 366 F ++ + L+NPRT K+ R+ A EL+DAI A DPGL+FLD INR NPV Sbjct 364 EFFEKLDNDDYVDLINPRTKKVTKRIKAKELWDAIIDQAWKTADPGLIFLDEINRKNPVK 423 Query 367 GRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVIDV 426 G IE+TNPCGE PLLPYESCNLGSINL++ + +D+DRL E +A RFLDDVID Sbjct 424 NVGDIESTNPCGEQPLLPYESCNLGSINLSKYVNGKDIDYDRLRETVWLATRFLDDVIDA 483 Query 427 SRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTAS 486 +++P ++ + R TRKIGLGVMG A+LL L +PY+S EA+ +A ++M I + +H AS Sbjct 484 NKFPVEQIKKVTRMTRKIGLGVMGFADLLIKLEVPYNSWEALEIAEKVMSFINEESHKAS 543 Query 487 RRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRA 545 + LAEERG FPA+ S + + G + RN+ T++APTGTIS+IAG ++ IEP+FA+AF R Sbjct 544 QHLAEERGVFPAWYGSEWEKEGIKMRNSTTTTIAPTGTISIIAGCSSSIEPIFALAFVRH 603 Query 546 IV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAP 604 ++ G+ LLEVNP F+ R G Y +EL+ ++A+ G + + E++ F TA E+ P Sbjct 604 VLNGQELLEVNPLFEEKTRSLGLYSEELMRKVAETGNLENI-EINEEIKKIFVTAHEVDP 662 Query 605 QWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQV 664 QWH+ MQA QR+ ++ VSKT+N+ + AT +D+ Y A KGITVYR S+ QV Sbjct 663 QWHVLMQATFQRYCDSGVSKTINMKSDATREDIAKAYRMAKDLHCKGITVYRDKSKTVQV 722 Query 665 LS 666 L+ Sbjct 723 LT 724 >gi|322418582|ref|YP_004197805.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Geobacter sp. M18] gi|320124969|gb|ADW12529.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Geobacter sp. M18] Length=745 Score = 583 bits (1504), Expect = 2e-164, Method: Compositional matrix adjust. Identities = 275/562 (49%), Positives = 393/562 (70%), Gaps = 5/562 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 L+ A+TVL +RYL D+ G+ E+ ++ R A +A A+ ++ + +++F + Sbjct 13 LTKNALTVLEKRYLKRDQTGKTLETAADMFRRVATAIAQADSVFDKKADISALSDKFYNM 72 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + N EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF ++ A + ++GGGTG++FS Sbjct 73 MTNFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFESVKYTALIHKSGGGTGFSFS 132 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D A + GG RRGA MA+L V HPDI DF+ Sbjct 133 RLRPANDVVMSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMAILRVDHPDIMDFIMC 192 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 K + +L +FN+SVG+T+ F++AV+ + + LVNPR K + A ++F+ I K A Sbjct 193 KNDQ-RQLNNFNISVGITEEFMKAVDADKDYNLVNPRDKKQAGTLNARKVFNRIVKQAWE 251 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +N+ NP P G IE+TNPCGE PLLPYESCNLGSINL +M+ G+VDWD Sbjct 252 NGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVVHGKVDWD 311 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 +L+EV AV FLD+VI+V+ YP ++ + R+ RKIGLGVMG A++L LGIPY SEE+ Sbjct 312 KLKEVVQTAVHFLDNVIEVNNYPLEQIDQMTRSNRKIGLGVMGWADMLIMLGIPYGSEES 371 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG--PRRNAQVTSVAPTGTIS 525 V L ++M+ I ASR+LA+ RGAFP F S + G P RNA VT++APTGTIS Sbjct 372 VELGEKVMQFINDEGKIASRKLAKSRGAFPNFKGSIYDAPGADPIRNATVTTIAPTGTIS 431 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRHLL-EVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA++F R ++ +++L EVNP F+++A+D+GFY +EL+ IA+ G V+ Sbjct 432 IIANASSGVEPLFAVSFVRQVMDKNILVEVNPLFEKIAKDQGFYSEELMQRIAEHGTVQD 491 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 +P VR F TA +I P+ H+ MQAA QRH + AVSKTVN P AT++DV +Y A Sbjct 492 ISAIPEGVRDVFVTAHDITPEEHITMQAAFQRHTDNAVSKTVNFPREATIEDVEKVYRLA 551 Query 645 WKAKVKGITVYRYGSREGQVLS 666 +++ KG+T+YR GSR+ QVLS Sbjct 552 YESNCKGVTIYRDGSRDEQVLS 573 >gi|206889598|ref|YP_002247982.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermodesulfovibrio yellowstonii DSM 11347] gi|206741536|gb|ACI20593.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermodesulfovibrio yellowstonii DSM 11347] Length=741 Score = 583 bits (1503), Expect = 3e-164, Method: Compositional matrix adjust. Identities = 283/566 (50%), Positives = 385/566 (69%), Gaps = 4/566 (0%) Query 103 VRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSR--RW 160 ++ +L+ A+ VL+ RYL +E G E+ EL R A +A + Y R Sbjct 4 IKQTFELTDNAIEVLKRRYLKKNEDGILIETPEELFTRVATAIAQIDTIYGKSEKEVYRT 63 Query 161 AERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGG 220 E F L+ +L FLPNSPTLMN+GT LG L+ CFVLP+EDS++ IF + AA + ++GG Sbjct 64 KEEFFELMTSLRFLPNSPTLMNAGTPLGQLSACFVLPVEDSMEGIFDAVKYAAIIHKSGG 123 Query 221 GTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPD 280 GTG++FS LRP GD V ST G +SGPVSF+ ++DSA V GGRRRGA M +L V HPD Sbjct 124 GTGFSFSRLRPKGDVVGSTKGISSGPVSFMSVFDSATEAVKQGGRRRGANMGLLRVDHPD 183 Query 281 ICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDA 340 I +F+T K + ++ +FN+SVG+T+ F++AV + + L+NPR+GKIV R+ A E+FD Sbjct 184 ILEFITCK-DDLTKFTNFNISVGLTEEFMKAVINDEEYELINPRSGKIVKRLKAKEVFDL 242 Query 341 ICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA 400 I A G+PG+VFLD IN ANP P G IEATNPCGE PLLPYESCNLGSINLA+M+ Sbjct 243 IVHQAWKNGEPGIVFLDRINAANPTPSLGEIEATNPCGEQPLLPYESCNLGSINLAKMVK 302 Query 401 DGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGI 460 D VDW+ L++ AV FLD+VID ++YP + + +A RKIGLGVMG A++L L I Sbjct 303 DNSVDWELLKDTVWKAVHFLDNVIDANKYPLSLIEQNTKANRKIGLGVMGWADMLIQLKI 362 Query 461 PYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAP 520 PY+S+EA+ LA LM+ I AS+ LA+ERG FP + S + P RNA +T++AP Sbjct 363 PYNSKEALNLAEELMKFILHEGRLASKELAKERGTFPNYAKSIYYDKMPLRNATITTIAP 422 Query 521 TGTISLIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQR 579 TGT+S+IAG ++GIEP+FA+ F R ++ G L+EVNP F + G + D L +IA+ Sbjct 423 TGTLSIIAGCSSGIEPLFALCFARNVMDGTRLVEVNPYFKKEMEKIGIWSDSLADKIAET 482 Query 580 GGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRA 639 G ++G +P E++ F TA E++P H+RMQAA Q++V+ AVSKTVNLP AT +DVR Sbjct 483 GSIQGIKEIPEEIKKIFVTAHEVSPSEHIRMQAAFQQYVDNAVSKTVNLPNQATEEDVRE 542 Query 640 IYVAAWKAKVKGITVYRYGSREGQVL 665 +Y+ A++ KG+TVYR GSR GQV+ Sbjct 543 VYLLAYRLGCKGVTVYRDGSRHGQVI 568 >gi|189425377|ref|YP_001952554.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter lovleyi SZ] gi|189421636|gb|ACD96034.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Geobacter lovleyi SZ] Length=745 Score = 581 bits (1498), Expect = 1e-163, Method: Compositional matrix adjust. Identities = 272/562 (49%), Positives = 394/562 (71%), Gaps = 5/562 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 L+ A+TVL +RYL D G+P E+ ++ R A +A + +++ + ++ A+RF + Sbjct 13 LTPNALTVLEKRYLKRDTSGKPLETPADMFRRVAETIAEPDKKFDKKADVKKLADRFYEM 72 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + + +FLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF + A + ++GGGTG++FS Sbjct 73 IVSFDFLPNSPTLMNAGRELGQLSACFVLPVGDSIEEIFDAVKFTAMIHKSGGGTGFSFS 132 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V +T G +SGP+SF+R++D+A + GG RRGA M +L V HP+I DF+ Sbjct 133 RLRPANDLVKTTTGVSSGPISFMRVFDTATETIKQGGTRRGANMGILRVDHPNIMDFIMC 192 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 KA+ +FN+SVG+T+ F+ AVER+ + L+NPR + + A ++F I A Sbjct 193 KADQ-KLFNNFNISVGLTEKFMEAVERDEEYDLLNPRDKSKMGTLNARKVFQRIVNQAWE 251 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +NR NP P G IE+TNPCGE PLLPYESCNLGSINL R +++G +DW Sbjct 252 NGEPGIIFLDRLNRDNPTPHVGEIESTNPCGEQPLLPYESCNLGSINLGRFVSEGAIDWS 311 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 RL+ V AV FLD+VI+ ++YP ++ + + RKIGLGVMG A++L LGIPY+S+EA Sbjct 312 RLKGVIHDAVHFLDNVIEANKYPLQQIHDMTHSNRKIGLGVMGWADMLILLGIPYNSDEA 371 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG--PRRNAQVTSVAPTGTIS 525 V+L ++M+ I H ASR L ++RG+FP FT S F + G P+RNA VT++APTGTIS Sbjct 372 VKLGKKVMQFINDEGHAASRELGQKRGSFPNFTGSTFDKKGALPQRNATVTTIAPTGTIS 431 Query 526 LIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FAI++ + ++ G L+EVNP F++LA++RGFY EL+ +IA+ G V Sbjct 432 MIANASSGVEPLFAISYVKNVMDGTKLVEVNPTFEQLAKERGFYSAELMEKIAEHGSVHD 491 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 +PA+VR F TA +I P+ H++MQAA Q H + AVSKTVN P TAT++DV +Y+ A Sbjct 492 LDEVPADVRRVFVTAHDITPEDHIQMQAAFQYHTDNAVSKTVNFPNTATIEDVENVYMLA 551 Query 645 WKAKVKGITVYRYGSREGQVLS 666 +K KG+T+YR GSR+ QVLS Sbjct 552 YKTGCKGVTIYRDGSRDEQVLS 573 >gi|301058132|ref|ZP_07199184.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [delta proteobacterium NaphS2] gi|300447764|gb|EFK11477.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [delta proteobacterium NaphS2] Length=830 Score = 581 bits (1497), Expect = 2e-163, Method: Compositional matrix adjust. Identities = 314/650 (49%), Positives = 426/650 (66%), Gaps = 36/650 (5%) Query 39 DPDMPGTVAKAVADALGRGIAPVE-------DIQDCVEARLGEAGLDDVARVYIIYRQRR 91 DPD A V+ L + IA +E I+ +EA+L E GL ++ Sbjct 38 DPDQ----AMDVSRFLRKEIAKLELQTITMPIIEHMIEAKLREFGLSAMS---------- 83 Query 92 AELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQ 151 LR K+ V+ L+LS AV VL RYL D++GR E+ E+ R A +A AE + Sbjct 84 -PLRLDKSFF-VKQGLELSDNAVRVLERRYLRQDKEGRAIETPEEMFARVAHHIAQAEKR 141 Query 152 YEPGSSRRWAER---FATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFAT 208 Y G R + F L+ +FLPNSPTLMN+G +LG LA CFVLP+EDS+ IF + Sbjct 142 Y--GGEDRIKDVEAVFYRLMTEFKFLPNSPTLMNAGRELGQLAACFVLPVEDSMDGIFDS 199 Query 209 LGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRG 268 L AA + ++GGGTG++FS LRP RV +TGG ASGPVSF++++++A V GG RRG Sbjct 200 LKNAALIHKSGGGTGFSFSRLRPKKSRVGTTGGIASGPVSFMKIFNTATEQVKQGGTRRG 259 Query 269 ACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKI 328 A MA+L V HPDI +F+ K + EL +FN+SVGVTDAF+ +V+ + + L++PR G+ Sbjct 260 ANMAILRVDHPDILEFIDCKKNN-EELNNFNISVGVTDAFMESVKADTNYDLIDPRNGRK 318 Query 329 VARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESC 388 ++ A E++DA+ + A GDPG+VFLD +N+ NP PG G IE+TNPCGE PLLP E+C Sbjct 319 TGQLNAKEVYDALIQRAWENGDPGIVFLDKVNQDNPTPGLGEIESTNPCGEQPLLPMEAC 378 Query 389 NLGSINLARMLADGR----VDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKI 444 NLGSINLA+ + D VD+ L+EV +V FLD+ ID+SRYP PE+GE R RKI Sbjct 379 NLGSINLAKFVVDTDEGPAVDYAGLKEVVRESVHFLDNTIDMSRYPLPEIGEMVRGNRKI 438 Query 445 GLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRF 504 GLGVMG A+LL L IPYDSE+A+ A +M +Q+A+H ASR+LAEERG F F S F Sbjct 439 GLGVMGFADLLYQLRIPYDSEKALETAEAVMGFVQEASHQASRQLAEERGVFGNFDKSVF 498 Query 505 AR--SGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGR-HLLEVNPCFDRL 561 R RNA T++APTGT+S+IAG ++GIEP+FA++F R ++ L+E NP F+ Sbjct 499 KRRKDCSYRNATTTTIAPTGTLSIIAGCSSGIEPLFALSFARNVMDNDRLVETNPYFEET 558 Query 562 ARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAA 621 A+ +G++ EL+ +AQ+G + +PAE RA F TA +I P+WHLRMQAA QRH + A Sbjct 559 AKKKGYFSSELMDIVAQKGTIHNINEIPAEDRAVFVTAHDIVPEWHLRMQAAFQRHTDNA 618 Query 622 VSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQVLSYAAPK 671 VSKTVNLP ATV+DV+ +Y A++ KG+T+YR GS+E QVLS+ K Sbjct 619 VSKTVNLPRDATVEDVKEVYDLAYELSCKGVTIYRDGSKENQVLSFTDKK 668 >gi|222056106|ref|YP_002538468.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter sp. FRC-32] gi|221565395|gb|ACM21367.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Geobacter sp. FRC-32] Length=742 Score = 581 bits (1497), Expect = 2e-163, Method: Compositional matrix adjust. Identities = 278/573 (49%), Positives = 398/573 (70%), Gaps = 9/573 (1%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 LS AVTVL +RYL D+ G+ ES ++ R A +AAA+ +++ + A++F + Sbjct 12 LSKNAVTVLEKRYLKRDKDGKVLESPVDMFRRVAESIAAADARFDKKADIAALADKFFAM 71 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + + EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF + A + ++GGGTG++FS Sbjct 72 MTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKHTALIHKSGGGTGFSFS 131 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D A + GG RRGA M +L V HPDI DF+ Sbjct 132 RLRPANDMVMSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMGILRVDHPDIMDFIMC 191 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 KA+ +L +FN+SVG+T+ F++AV+ + + L+NPR+G+ + A ++F+ I K A Sbjct 192 KADQ-RQLNNFNISVGLTEEFMKAVDADREYNLINPRSGEKAGSLNARKVFNRIVKQAWE 250 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++F+D +N+ NP P G+IE+TNPCGE PLLPYESCNLGSINL +M+ G ++W Sbjct 251 NGEPGIIFIDRLNKDNPTPHIGQIESTNPCGEQPLLPYESCNLGSINLGKMVEHGEINWQ 310 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 RL+EV +AV FLD+VI+V+ YP ++ RA RKIGLGVMG A+LL LGIPY+S+EA Sbjct 311 RLKEVILLAVNFLDNVIEVNNYPLEQIDAMTRANRKIGLGVMGWADLLILLGIPYNSKEA 370 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG--PRRNAQVTSVAPTGTIS 525 + L ++M+ I H AS +LA+ RG FP F S F + G P RNA VT++APTGTIS Sbjct 371 IELGEKIMKFINDEGHAASVQLAKVRGPFPNFKGSIFDKPGMEPIRNATVTTIAPTGTIS 430 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRH-LLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA++F R ++ ++ LLEVNP F+ A+ GFY +EL+ +IA+ G V Sbjct 431 IIANASSGVEPLFAVSFIRQVMDKNILLEVNPIFEETAKKEGFYSEELMQKIAEHGTVHD 490 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 P +P ++R F TA +I P+ H+ MQAA Q+H + AVSKTVN P +AT+++V +Y A Sbjct 491 IPEIPEQIRNVFVTAHDITPEVHISMQAAFQKHTDNAVSKTVNFPNSATIEEVEKVYRLA 550 Query 645 WKAKVKGITVYRYGSREGQVLSYA----APKPL 673 ++ KG+T+YR GSR+ QVLS APK L Sbjct 551 YETNCKGVTIYRDGSRDEQVLSTGKKDEAPKTL 583 >gi|77919448|ref|YP_357263.1| ribonucleotide-diphosphate reductase subunit alpha [Pelobacter carbinolicus DSM 2380] gi|77545531|gb|ABA89093.1| ribonucleoside-diphosphate reductase 2, alpha subunit [Pelobacter carbinolicus DSM 2380] Length=744 Score = 579 bits (1492), Expect = 7e-163, Method: Compositional matrix adjust. Identities = 282/565 (50%), Positives = 395/565 (70%), Gaps = 6/565 (1%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGS-SRRWAERFATL 167 LS A+TVL+ RYL D+ GR E ++ R A VA AE + G + A+RF Sbjct 11 LSKNALTVLKRRYLKRDQDGRILEDPADMFRRVADAVADAETRLASGQDATSLADRFYDA 70 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + LEFLPNSPTLMN+G +LG L+ CFVLP++DS++SIF + Q A + ++GGGTG++FS Sbjct 71 MTCLEFLPNSPTLMNAGRELGQLSACFVLPVDDSMESIFEAIKQTALIHKSGGGTGFSFS 130 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 +RPA D V ST G +SGP+SF++++D+A + GG RRGA M +L V HPDI DF+ Sbjct 131 RIRPANDVVLSTKGVSSGPISFMKVFDAATETIKQGGTRRGANMGILRVDHPDIMDFIMV 190 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 K + + L +FNLSVG+T+AF++AVE + L+NPRTG+ + ++ A ++FD I A Sbjct 191 KKDL-TVLTNFNLSVGLTEAFMKAVEEGQEYDLLNPRTGEPLKKLDARKVFDRIIDMAWT 249 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA-DGRVDW 406 G+PG++FLD +NR NP P G IEATNPCGE PLLPYESCNLGSINL+RM+ DG VDW Sbjct 250 SGEPGIIFLDRLNRDNPTPHVGEIEATNPCGEQPLLPYESCNLGSINLSRMVTGDGEVDW 309 Query 407 DRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEE 466 ++L + + VRFLD+VI+++RYP P++ E + RKIGLG+MG A++L LG+PY+S + Sbjct 310 EKLRDTVQLGVRFLDNVIEINRYPLPQISEMTLSNRKIGLGIMGWADMLILLGLPYNSSQ 369 Query 467 AVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRF--ARSGPRRNAQVTSVAPTGTI 524 A+ LA +LM I A S +LAE+RGAFP F S + A GP RNA T++APTGTI Sbjct 370 AIALADKLMNFITTEARATSVKLAEQRGAFPNFPGSSYDQAGDGPLRNATCTTIAPTGTI 429 Query 525 SLIAGTTAGIEPMFAIAFTRAIVGRH-LLEVNPCFDRLARDRGFYRDELIAEIAQRGGVR 583 S+IA T++G+EP+FA+++ R ++ L+EV+P F+ +A GFY EL+ IA++G ++ Sbjct 430 SIIANTSSGVEPIFAVSYIRQVMDNDVLVEVHPLFEAIAHKEGFYSPELMKAIAEKGTIQ 489 Query 584 GYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVA 643 G+ +P +VR F TA +I P+ H+ MQAA Q+H + AVSKTVN P +AT ++V +Y Sbjct 490 GFDEIPEKVRKLFVTAHDITPEDHIHMQAAFQKHTDNAVSKTVNFPHSATREEVAEVYRL 549 Query 644 AWKAKVKGITVYRYGSREGQVLSYA 668 A+K KG+T+YR GSR+ QVLS A Sbjct 550 AYKEGCKGVTIYRDGSRDMQVLSVA 574 >gi|302390649|ref|YP_003826470.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermosediminibacter oceani DSM 16646] gi|302201277|gb|ADL08847.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermosediminibacter oceani DSM 16646] Length=772 Score = 578 bits (1491), Expect = 9e-163, Method: Compositional matrix adjust. Identities = 288/568 (51%), Positives = 406/568 (72%), Gaps = 9/568 (1%) Query 106 ELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFA 165 +L+L+ A VL++RYL DE+G+ E+ ++++R AR VAAAE+ Y WAE+F Sbjct 5 KLRLTENARVVLQKRYLAKDEKGQVVETPEDMIERVARAVAAAEENYGQ-DPEFWAEKFY 63 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 ++ L+F+PNSPTLMN+G +LG L+ CFVLP+EDS++ IF + AA + ++GGGTG + Sbjct 64 DMMAELKFMPNSPTLMNAGRELGQLSACFVLPVEDSMEGIFGAIKNAALIHKSGGGTGMS 123 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS LRP G V STGG ASGPVSF++++++A V GGRRRGA M +L V HPDI +F+ Sbjct 124 FSRLRPKGATVRSTGGEASGPVSFMKVFNAATEAVKQGGRRRGANMGILRVDHPDILEFI 183 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 K E +EL +FN+SV +TD F+ ++ +G + LV+P TGK+ R+ A E+FD I A Sbjct 184 RCK-EDNNELTNFNISVAITDKFMETLKNDGTYELVDPNTGKVTGRLKAREVFDLIVDMA 242 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADG--- 402 G+PG++F+D +N NP P G+IE+TNPCGE PLLP+ESCNLGSINL++ + +G Sbjct 243 WKNGEPGILFIDRVNAKNPTPHIGQIESTNPCGEQPLLPFESCNLGSINLSKFVKEGSTG 302 Query 403 -RVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIP 461 +D++ L++V +AVRFLDDVIDV++YP PE+ + +A RKIGLGVMG A++L LGIP Sbjct 303 NEIDYEELKQVVHMAVRFLDDVIDVNKYPLPEIEQMTKANRKIGLGVMGFADMLIKLGIP 362 Query 462 YDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRF-ARSGP-RRNAQVTSVA 519 YDSEEAV+LA +M IQ+ A AS LA+ RGAFP F S + GP RNA VT++A Sbjct 363 YDSEEAVKLAEEVMGFIQREARKASEDLAKTRGAFPNFPGSVYDVPGGPLLRNATVTTIA 422 Query 520 PTGTISLIAGTTAGIEPMFAIAFTRAIVGRH-LLEVNPCFDRLARDRGFYRDELIAEIAQ 578 PTGTIS+IAG ++GIEP+FA+AF R ++ + L+E+ P F+ R RG Y EL+ E+ + Sbjct 423 PTGTISIIAGCSSGIEPVFALAFERNVLDKQRLIEIYPLFEEEMRRRGLYSPELMEEVLE 482 Query 579 RGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVR 638 +G ++G +P EV+ F TA +I+P+WH+R+QAA Q++ + AVSKTVN P +AT +DV+ Sbjct 483 KGSLKGIAGIPEEVKRVFVTAHDISPEWHVRIQAAFQKYTDNAVSKTVNFPHSATREDVK 542 Query 639 AIYVAAWKAKVKGITVYRYGSREGQVLS 666 +Y+ A++ KG+TVYR GSRE QVL Sbjct 543 KVYLLAYELGCKGVTVYRDGSREEQVLK 570 >gi|297568305|ref|YP_003689649.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Desulfurivibrio alkaliphilus AHT2] gi|296924220|gb|ADH85030.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Desulfurivibrio alkaliphilus AHT2] Length=755 Score = 576 bits (1485), Expect = 4e-162, Method: Compositional matrix adjust. Identities = 294/598 (50%), Positives = 396/598 (67%), Gaps = 14/598 (2%) Query 91 RAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAED 150 +A ++TAK G+ K S A+TVL+ RYL DEQG+ ES ++ R A +A +E Sbjct 4 KASIKTAKMPAGLIKP-KFSANAMTVLKRRYLKKDEQGKVLESPQRMLWRVASTIANSER 62 Query 151 QYE-PGSSRRWAERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATL 209 Y+ + A F L+ L+F+PNSPTLMN+G LG L+ CFVLPIEDS+ SIF + Sbjct 63 LYDATADTEALAMEFYRLMAELDFMPNSPTLMNAGRKLGQLSACFVLPIEDSMPSIFEAV 122 Query 210 GQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGA 269 Q A + ++GGGTG++FS +RP D V ST G +SGP+SF+ ++D A + GG RRGA Sbjct 123 KQTALIHQSGGGTGFSFSRIRPKNDVVHSTKGISSGPLSFMSVFDCATETIKQGGTRRGA 182 Query 270 CMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIV 329 MA+L V HPDI DF+ K++ L +FNLSV +TD F+RA+ NG + L+NPR G+IV Sbjct 183 NMAILRVDHPDIMDFIKVKSDL-DVLHNFNLSVAITDEFMRALAENGDYALINPRNGEIV 241 Query 330 ARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCN 389 AA+LF I K A G+PG+VF+D IN NP P G IE+TNPCGE PLLPYESCN Sbjct 242 RYQNAAKLFRQIVKQAWLSGEPGVVFIDRINAENPTPEAGEIESTNPCGEQPLLPYESCN 301 Query 390 LGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVM 449 LGSINLA M+ DG++D++RL AV FLD+V+D++ YP PE+ + + RKIGLGVM Sbjct 302 LGSINLANMVKDGKLDYERLGYCVDTAVHFLDNVVDINNYPLPEIEQVTKQNRKIGLGVM 361 Query 450 GLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGP 509 G A+LL L IPY S+EAV LA LMR I + A AS L + RGAFP F DS + R P Sbjct 362 GFADLLVQLEIPYSSQEAVELAEALMRFIDERALKASIALGKSRGAFPNFPDSIYGRQDP 421 Query 510 R---RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGR-HLLEVNPCFDRLARDR 565 + RNA T++APTGTIS++AG ++G+EP+FA+AF R ++ L EVNP F+++A++ Sbjct 422 KTPVRNATRTTIAPTGTISILAGCSSGVEPLFAVAFLRRVMDNDELFEVNPRFEKIAKEE 481 Query 566 GFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKT 625 GFY EL+ +IA G + G +PA+ R F TA +I P+ H+ +QA+ QRH AVSKT Sbjct 482 GFYSHELVKQIAHNGTLAGLEEIPAKYRRIFETAHDITPENHIAIQASFQRHTNNAVSKT 541 Query 626 VNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQVLSY-------AAPKPLLAQ 676 +N P AT ++VR Y+ A++ KG+T+YR G RE QVL+ AA P+L Q Sbjct 542 INFPHQATEEEVRQAYLLAYELNCKGMTIYRDGCRENQVLNIGKTDKKAAAAVPVLPQ 599 >gi|300088374|ref|YP_003758896.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Dehalogenimonas lykanthroporepellens BL-DC-9] gi|299528107|gb|ADJ26575.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Dehalogenimonas lykanthroporepellens BL-DC-9] Length=902 Score = 576 bits (1485), Expect = 4e-162, Method: Compositional matrix adjust. Identities = 288/580 (50%), Positives = 395/580 (69%), Gaps = 8/580 (1%) Query 105 DELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAER- 163 +++ S A+ VL +RYL D+QG+ E+ +++ R AR VAAAE Y+P + R E Sbjct 151 EKVAFSDNALAVLNKRYLKKDKQGQAIEAPEDMLRRVARTVAAAELIYDPKCNVRNVENE 210 Query 164 FATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTG 223 F L+ LEFLPNSPTLMN+G +LG L+ CFVLPI+DS++SIF + A + ++GGGTG Sbjct 211 FYGLMARLEFLPNSPTLMNAGRELGQLSACFVLPIDDSIESIFDAVKHTAMIHKSGGGTG 270 Query 224 YAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICD 283 ++FS LRP DRV +TGG ASGPVSF+R +D A V+ GG RRGA MA+L + HPDI Sbjct 271 FSFSRLRPESDRVGTTGGVASGPVSFMRAFDVATDVIKQGGTRRGANMAILSIDHPDIEH 330 Query 284 FVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICK 343 F+TAK ++ L +FNLSV +TD F+ A + + L+NP+ G++ R A +FD I + Sbjct 331 FITAKQQA-GVLTNFNLSVAITDKFMEAARADEEYELINPQNGEVAGRRRARAIFDQIVQ 389 Query 344 AAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARML---A 400 A GDPG+VF+D IN NP P GRIE+TNPCGE PLLPYESCNLGS+NL++M+ Sbjct 390 LAWKTGDPGIVFIDRINAENPTPKLGRIESTNPCGEQPLLPYESCNLGSVNLSKMVKGNG 449 Query 401 DGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGI 460 +VD+D+L AVRFLDDVIDV+++P ++ E R TRKIGLGVMG A++L ALG+ Sbjct 450 KKQVDYDKLRYTVRTAVRFLDDVIDVNKFPLEQIAEQTRRTRKIGLGVMGFADMLIALGV 509 Query 461 PYDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAP 520 PY+S EA+R+ +M IQ +H AS LA+ERG FPA+ S++ RNA T++AP Sbjct 510 PYNSPEALRVGEEVMGFIQAESHRASSALADERGVFPAYEGSKYDGQVKMRNASCTTIAP 569 Query 521 TGTISLIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQR 579 TGT+S+IAG ++GIEP FA+ FTR I+ G ++EVNP F AR GFY +EL+ ++A+ Sbjct 570 TGTLSIIAGCSSGIEPHFALCFTRNIMDGTRMIEVNPYFAEAARSGGFYSEELMKKLAEG 629 Query 580 GGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRA 639 + +P EV+ F TA I P+ H++MQAA Q++ + AVSKTVN PA ATV V Sbjct 630 AHLEDMKEVPEEVKKLFVTAHSITPEGHVKMQAAFQKYTDNAVSKTVNFPADATVAHVEE 689 Query 640 IYVAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADT 679 +Y+ A+ K+KGIT+YR G + Q +S +P A+A+T Sbjct 690 VYLMAYDEKLKGITIYRDGCKADQPMSTGKAEP--AKAET 727 >gi|57234895|ref|YP_181092.1| ribonucleotide-diphosphate reductase subunit alpha [Dehalococcoides ethenogenes 195] gi|57225343|gb|AAW40400.1| ribonucleotide reductase [Dehalococcoides ethenogenes 195] Length=761 Score = 575 bits (1483), Expect = 6e-162, Method: Compositional matrix adjust. Identities = 285/567 (51%), Positives = 388/567 (69%), Gaps = 9/567 (1%) Query 107 LKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAE-RFA 165 LKL+ A+ VL RYL D+QG+P+E+ ++ R AR +A E Y P + R E F Sbjct 20 LKLTDNAMCVLERRYLKKDKQGKPSETVEDMFRRVARTIAMGELIYNPKADVRSREDEFY 79 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 ++ LEFLPNSPTLMN+G +LG L+ CFVLP++DS++SIF + A + ++GGGTG++ Sbjct 80 NIMTRLEFLPNSPTLMNAGRELGQLSACFVLPVDDSIESIFDAVKHTAMIHKSGGGTGFS 139 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS LRP DRV +TGG ASGPVSF+R +D A V+ GG RRGA MA+L + HPDI F+ Sbjct 140 FSRLRPEQDRVGTTGGVASGPVSFMRAFDVATDVIKQGGTRRGANMAILSIDHPDIMKFI 199 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 AK + L +FNLSV +TD F++AV+ + L+NP G++V+R+ A E+F+ I A Sbjct 200 HAK-DKAGVLTNFNLSVAITDKFMQAVKDGVDYDLLNPHNGEVVSRLNATEVFNKIVHMA 258 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA----D 401 GDPG+VF+D IN NP P GRIE+TNPCGE PLLPYESCNLGSINL+RM+ Sbjct 259 WKTGDPGIVFIDRINAYNPTPQLGRIESTNPCGEQPLLPYESCNLGSINLSRMVTVSGGQ 318 Query 402 GRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIP 461 VD+ +L V AVRFLD+VIDV+++P P++ E + +RKIGLGVMG A++L LGIP Sbjct 319 AVVDYKKLSRVVKSAVRFLDNVIDVNKFPLPQIEEMTKKSRKIGLGVMGFADMLLELGIP 378 Query 462 YDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSG-PRRNAQVTSVAP 520 Y+SE +++LA +M + + AH S LA ERG FPA+ S + +SG P RNA T++AP Sbjct 379 YNSENSIKLAEEIMCFVNEEAHKFSSELAVERGVFPAYRGSIYEKSGRPMRNASCTTIAP 438 Query 521 TGTISLIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQR 579 TGT+S+IAG ++GIEP FA+ FTR I+ G ++EVNP F+R A++ G+Y +ELI +A+ Sbjct 439 TGTLSIIAGCSSGIEPHFALCFTRNILDGTKMIEVNPYFERAAKEGGYYSEELIKSLAE- 497 Query 580 GGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRA 639 G +PAE + F TA +I P+WH+R+QAA Q+ + AVSKTVN A DV Sbjct 498 GAHLDEADVPAEAKELFVTAHQIVPEWHVRIQAAFQKCTDNAVSKTVNFSREAVEGDVAE 557 Query 640 IYVAAWKAKVKGITVYRYGSREGQVLS 666 +Y A + +KGIT+YR GSRE Q +S Sbjct 558 VYKMAHDSNLKGITIYRDGSREDQPMS 584 >gi|118580911|ref|YP_902161.1| ribonucleotide-diphosphate reductase subunit alpha [Pelobacter propionicus DSM 2379] gi|118503621|gb|ABL00104.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Pelobacter propionicus DSM 2379] Length=744 Score = 573 bits (1478), Expect = 3e-161, Method: Compositional matrix adjust. Identities = 278/564 (50%), Positives = 390/564 (70%), Gaps = 5/564 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQY-EPGSSRRWAERFATL 167 LS A+TVL +RYL G E+ ++ R A +AAA+ + E + + F + Sbjct 13 LSKNALTVLEKRYLRRGPNGTTLETAADMFRRVADTIAAADRSFDETADTAGLGDTFYRM 72 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + + EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF + A + ++GGGTG++FS Sbjct 73 MTSFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFDAVKYTALIHKSGGGTGFSFS 132 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V+ST G +SGP+SF+R++D A + GG RRGA MA+L V HPDI DF+ Sbjct 133 RLRPANDMVSSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMAILRVDHPDIVDFIMC 192 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 KA+ +L +FN+SVG+T+ F++AVER+ + LVNPR GK + A ++F I K A Sbjct 193 KADQ-KQLNNFNISVGLTEKFMQAVERDEEYTLVNPRNGKQHGTLNARKVFQRIVKQAWE 251 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG+VFLD +NR NP P G IE+TNPCGE PLLPYESCNLGSINL + +A+G +DW+ Sbjct 252 NGEPGIVFLDRLNRDNPTPQVGEIESTNPCGEQPLLPYESCNLGSINLGKFVAEGAIDWN 311 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 RL+E AV FLD+VI+ + YP ++ + RKIGLGVMG A++L LGIPY S EA Sbjct 312 RLKETVRNAVHFLDNVIEANSYPLQQIHDMTHGNRKIGLGVMGWADMLILLGIPYSSPEA 371 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRF--ARSGPRRNAQVTSVAPTGTIS 525 V+L T++M+ I ASR L + RG+FP FT S F + P RNA VT++APTGTIS Sbjct 372 VKLGTKVMKFINDEGRLASRELGKVRGSFPNFTGSTFDIKDAEPMRNATVTTIAPTGTIS 431 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRH-LLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA+++ R ++ ++ L+EVNP F+R+A++RGFY + L+ IA+ G V+G Sbjct 432 IIANASSGVEPLFAVSYLRTVMDKNVLVEVNPHFERIAKERGFYSESLMKRIAEHGTVQG 491 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 P +P +V+ F TA +I+P H++MQAA Q H + AVSKTVN P +AT++DV +Y A Sbjct 492 IPEVPQDVQEMFVTAHDISPNDHIQMQAAFQLHTDNAVSKTVNFPNSATIEDVENVYRLA 551 Query 645 WKAKVKGITVYRYGSREGQVLSYA 668 ++ KG+T+YR GSR+ QVLS A Sbjct 552 YQTGCKGVTIYRDGSRDEQVLSTA 575 >gi|16082440|ref|NP_394926.1| ribonucleotide-diphosphate reductase subunit alpha [Thermoplasma acidophilum DSM 1728] gi|10640815|emb|CAC12593.1| ribonucleotide reductase [Thermoplasma acidophilum] Length=770 Score = 573 bits (1476), Expect = 5e-161, Method: Compositional matrix adjust. Identities = 313/723 (44%), Positives = 439/723 (61%), Gaps = 65/723 (8%) Query 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDD-PDMPGTVAKAVADALGRGIAPVEDIQD 66 +V +RDGT+VPF+ +I A+ +A V D K VA + VE+IQD Sbjct 6 EVVKRDGTVVPFEKNKITMAIYKAMLSVKNGTMKDAEQLADKVVARLKDKERPSVEEIQD 65 Query 67 CVEARLGEAGLD-----DVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER- 120 VE L + +D DVA+ YI+YR++R +R K L+GV+D+LKL+L AV VL R Sbjct 66 VVEDVLMTSKIDGKTFTDVAKSYILYREKRRAIREEKELMGVKDDLKLTLNAVKVLEARY 125 Query 121 --------------------------------YLLHDEQGR---PAESTGELMDRSARCV 145 Y+ + + G+ AE G++ + Sbjct 126 LLKDEDGKIIETPRQMFRRVASHIGIVEALYDYIKYKKTGKVPENAEIIGKVSPTQEEVL 185 Query 146 AAA-----ED--------------QYEPGSSRRWAERFATLLRNLEFLPNSPTLMNSGTD 186 A ED Q + S+ + RF ++ +L+F+PNSPTLMN+GT Sbjct 186 RRAFGYMKEDGIIEGTFEEFMDFIQTKGTSAGHYINRFEEVMSSLDFVPNSPTLMNAGTK 245 Query 187 LGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGP 246 LG L+ CFVLP+ DS++ IF TL A + ++GGGTG++FS LRP D V ST G ASGP Sbjct 246 LGQLSACFVLPVGDSIEDIFETLKNTALIHKSGGGTGFSFSRLRPKDDIVGSTKGVASGP 305 Query 247 VSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTD 306 VSF++++D V+ GG+RRGA M +L+ +HPDI +F+ +K L +FN+SVGVTD Sbjct 306 VSFMKIFDVTTDVIKQGGKRRGANMGILNYNHPDIMEFILSKDSENKVLSNFNISVGVTD 365 Query 307 AFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVP 366 F ++ + LVNPRT KI+ R+ A E++DAI A DPGL+FLD INR NPV Sbjct 366 DFFDKLDNDDYVDLVNPRTKKIMKRIKAREIWDAIIDQAWKTADPGLIFLDEINRKNPVK 425 Query 367 GRGRIEATNPCGEVPLLPYESCNLGSINLARMLADG-RVDWDRLEEVAGVAVRFLDDVID 425 G IE+TNPCGE PLLPYESCNLGSINL++ + DG ++D+DRL E A RFLDDVID Sbjct 426 NVGDIESTNPCGEQPLLPYESCNLGSINLSKYVVDGKKIDFDRLRETVWTATRFLDDVID 485 Query 426 VSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTA 485 +++P ++ + R TRKIGLGVMG A++L L IPY+S EA+ + ++M I +H A Sbjct 486 ANKFPVEQIKKVTRMTRKIGLGVMGFADMLIKLEIPYNSWEALEIGEKVMSFINDESHKA 545 Query 486 SRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTR 544 S+ LAEERG FPA+ S + + G + RN+ T++APTGTIS+IAG ++ IEP+FA+AF R Sbjct 546 SQALAEERGVFPAWYGSEWEKEGIKMRNSTTTTIAPTGTISIIAGCSSSIEPIFALAFVR 605 Query 545 AIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIA 603 ++ G+ LLEVNP F+ R+ G Y +EL+ ++A+ G + ++ EV+ F TA EI Sbjct 606 HVLNGQELLEVNPLFEEKTRELGIYSEELMRQVAETGNLENV-KINEEVKKIFVTAHEID 664 Query 604 PQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQ 663 PQWH+ MQA QR+ ++ VSKT+N+ + AT +D+ Y A KGITVYR S+ Q Sbjct 665 PQWHVLMQATFQRYCDSGVSKTINMRSDATREDIARAYRMAKDLHCKGITVYRDKSKTVQ 724 Query 664 VLS 666 VL+ Sbjct 725 VLT 727 >gi|148264309|ref|YP_001231015.1| ribonucleotide-diphosphate reductase subunit alpha [Geobacter uraniireducens Rf4] gi|146397809|gb|ABQ26442.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Geobacter uraniireducens Rf4] Length=742 Score = 573 bits (1476), Expect = 5e-161, Method: Compositional matrix adjust. Identities = 272/562 (49%), Positives = 392/562 (70%), Gaps = 5/562 (0%) Query 109 LSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFATL 167 LS A+TVL +RYL D++G+ E+ ++ R A +A A +++ + A++F + Sbjct 12 LSKNALTVLEKRYLKRDKEGKVLETPVDMFRRVAESIAVANARFDQKADLAALADKFYAM 71 Query 168 LRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFS 227 + EFLPNSPTLMN+G +LG L+ CFVLP+ DS++ IF + A + ++GGGTG++FS Sbjct 72 MTAFEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEEIFEAVKYTALIHKSGGGTGFSFS 131 Query 228 HLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTA 287 LRPA D V ST G +SGP+SF+R++D A + GG RRGA M +L V HPDI DF+ Sbjct 132 RLRPANDVVMSTTGISSGPLSFMRVFDVATETIKQGGTRRGANMGILRVDHPDIMDFIMC 191 Query 288 KAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHA 347 KA+ +L +FN+SVG+T+AF++AV+ + + +VNPR+G+ + A ++F+ I K A Sbjct 192 KADQ-RQLNNFNISVGITEAFMKAVDADTDYNIVNPRSGEKAGILNARKVFNRIVKQAWE 250 Query 348 GGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWD 407 G+PG++FLD +N+ NP P G IE+TNPCGE PLLPYESCNLGSINL +M+ +G V+W+ Sbjct 251 NGEPGIIFLDRLNKDNPTPHIGEIESTNPCGEQPLLPYESCNLGSINLGKMVQNGEVNWE 310 Query 408 RLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEA 467 RL+EV +AV FLD+VI+V+ YP ++ R+ RKIGLGVMG A++L LGIPY+S +A Sbjct 311 RLKEVIQLAVNFLDNVIEVNNYPLEQIDTMTRSNRKIGLGVMGWADMLILLGIPYNSMKA 370 Query 468 VRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFAR--SGPRRNAQVTSVAPTGTIS 525 + L ++M+ I H AS LA+ RG FP F S F GP RNA VT++APTGTIS Sbjct 371 IELGEKVMKFINDEGHAASVELAKTRGTFPNFKGSVFDAPGKGPIRNATVTTIAPTGTIS 430 Query 526 LIAGTTAGIEPMFAIAFTRAIVGRH-LLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRG 584 +IA ++G+EP+FA++F R ++ ++ LLEVNP F+ +A+ +GFY +EL+ +IA+ G V Sbjct 431 IIANASSGVEPLFAVSFVRQVMDKNILLEVNPIFEEIAKAQGFYSEELMKKIAEHGTVHD 490 Query 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644 P +P VR F TA +I P+ H+ MQAA Q++ + AVSKTVN P +AT +DV +Y A Sbjct 491 IPEIPEAVRNIFVTAHDITPEVHIAMQAAFQKYTDNAVSKTVNFPNSATFEDVEKVYRLA 550 Query 645 WKAKVKGITVYRYGSREGQVLS 666 +++ KG+T+YR GSR+ QVLS Sbjct 551 YESNCKGVTIYRDGSRDEQVLS 572 >gi|48478313|ref|YP_024019.1| ribonucleotide-diphosphate reductase subunit alpha [Picrophilus torridus DSM 9790] gi|48430961|gb|AAT43826.1| ribonucleoside-diphosphate reductase alpha chain [Picrophilus torridus DSM 9790] Length=773 Score = 572 bits (1475), Expect = 6e-161, Method: Compositional matrix adjust. Identities = 303/721 (43%), Positives = 430/721 (60%), Gaps = 65/721 (9%) Query 9 VRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP--VEDIQD 66 V +RDG+ VPFD +I A+ +A V + + AV D L + VE IQD Sbjct 8 VIKRDGSRVPFDKEKITMAIYKAMLSVKFGSMEDASKLTDAVIDELLKSDEEPTVERIQD 67 Query 67 CVEARLGEAGLDD-----VARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERY 121 VE L +++ VA+ YIIYR++R +R K L+GV+D+LKL+L A+ VL RY Sbjct 68 TVEKVLMTKKINNRDFTAVAKSYIIYREKRKTIREEKELIGVKDDLKLTLNAIKVLEARY 127 Query 122 LLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAE------RFATLLRN----- 170 L D+ G+ E+ ++ R A +A E Y+ +++ E + +L R Sbjct 128 LFKDQDGKIIETPRQMFHRVAVHLAIIEGLYDYRRYQKYNEIYQNGTVYTSLTRTQIDEL 187 Query 171 --------------------LEFL------------------------PNSPTLMNSGTD 186 L+F+ PNSPTLMN+G Sbjct 188 KRAFDELKAEGELTGSFEDFLDFIKTKRNHINEYIEKFEDVMSNLKFVPNSPTLMNAGGP 247 Query 187 LGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGP 246 LG L+ CFVLP++DS+ SIF L AE+ ++GGGTG++FS LR D VAST G ASGP Sbjct 248 LGQLSACFVLPVDDSIDSIFDALKYTAEIHKSGGGTGFSFSRLRAKDDIVASTKGVASGP 307 Query 247 VSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTD 306 +SF+R++D V+ GG+RRGA M +L HPDI DF+T+K L +FN+SV V D Sbjct 308 LSFMRIFDVTTDVIKQGGKRRGANMGILRYDHPDIMDFITSKDSENKVLSNFNISVAVED 367 Query 307 AFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVP 366 F ++ + L NPR GK+V R+ A+ +++ I A GDPG++FLD IN+ NPV Sbjct 368 EFFEKLDNDDYIELKNPRDGKVVNRIKASTIWNTIINQAWKTGDPGMIFLDEINKKNPVK 427 Query 367 GRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFLDDVIDV 426 G IE+TNPCGE PL+PYESCNLGSINL++ + DG+ D+D +E +A RFLD+V+D Sbjct 428 NIGYIESTNPCGEQPLMPYESCNLGSINLSKFVVDGKFDFDAYKETIDIATRFLDNVVDA 487 Query 427 SRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTAS 486 +++P ++ E R TRKIGLG+MG A++L LGIPY+S EA+ + R+M+ + +H S Sbjct 488 NKFPVDKIKEMTRKTRKIGLGLMGFADMLIMLGIPYNSNEALEIGERIMKFLNDESHLES 547 Query 487 RRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRA 545 +RLAEERG FP + S + + + RN+ T++APTGTIS+IAG ++ IEP+FAIAF R Sbjct 548 QRLAEERGVFPGWYGSDWEKQNIKMRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRH 607 Query 546 IV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAP 604 ++ G+ L+E+NP F+ R R Y D+L+ ++A+ G +R LP +++ F TA EI P Sbjct 608 VLNGQELIEINPLFENELRKRNLYSDDLMEKVARTGNLRDID-LPDDIKRVFVTAQEIDP 666 Query 605 QWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAAWKAKVKGITVYRYGSREGQV 664 WH+ MQA QR+ ++ VSKT+NLP AT DD+ Y A KGITVYR S+ QV Sbjct 667 DWHVLMQATFQRYCDSGVSKTINLPYEATPDDIARSYRLAKDLHCKGITVYRDRSKTQQV 726 Query 665 L 665 L Sbjct 727 L 727 >gi|220905096|ref|YP_002480408.1| ribonucleotide-diphosphate reductase subunit alpha [Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774] gi|219869395|gb|ACL49730.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774] Length=781 Score = 572 bits (1475), Expect = 6e-161, Method: Compositional matrix adjust. Identities = 288/586 (50%), Positives = 390/586 (67%), Gaps = 15/586 (2%) Query 115 TVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGS--SRRWAERFATLLRNLE 172 VL++RYL + G+ E+ +L R A +AA E+ Y+ S + A F L+ + + Sbjct 19 VVLQKRYLRKNLDGKIIEAPRDLFWRVAAAIAAQEENYKNSSRTPNQLARDFYDLMTSWK 78 Query 173 FLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPA 232 FLPNSPTLMN+GT+LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++FS LRP Sbjct 79 FLPNSPTLMNAGTELGQLSACFVLPVGDSIEEIFDAVKYAAMIHKSGGGTGFSFSRLRPK 138 Query 233 GDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESP 292 RV STGG ASGPVSFLR++++A + GG RRGA M +L V HPDI +F+ AK E Sbjct 139 DSRVGSTGGVASGPVSFLRIFNTATEQIKQGGTRRGANMGILRVDHPDILEFIRAK-EKE 197 Query 293 SELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPG 352 E +FNLSVG+T++F++AVE + + LV+P G+++ R+PA ++FD + + A GDPG Sbjct 198 GEFNNFNLSVGLTESFMQAVENDEQYDLVSPNNGEVMKRLPARDVFDLLVRKAWQSGDPG 257 Query 353 LVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGR--------- 403 +VFLD INR NP P +G IE+TNPCGE PLLP+E+CNLGSINL+ G Sbjct 258 IVFLDRINRDNPTPDQGEIESTNPCGEQPLLPFEACNLGSINLSCFHVPGHENSADPAAG 317 Query 404 VDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYD 463 +DWD L V ++VRFLD+VID SR+P +GE R RKIGLGVMG A+LL LG+PYD Sbjct 318 IDWDELRRVVHLSVRFLDNVIDASRFPLDRIGETVRKNRKIGLGVMGFADLLFQLGVPYD 377 Query 464 SEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARS--GPRRNAQVTSVAPT 521 S++ + L R+M +Q H AS LA ERG FPA+ S FAR GP RNA VT++APT Sbjct 378 SQQGLDLGERIMAFVQGEGHRASAELALERGPFPAYGSSVFARKKLGPYRNATVTTIAPT 437 Query 522 GTISLIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQRG 580 GT+S+IAG ++G+EP+FA+ FTR I+ G L+E+NP F+ G + EL+ + +G Sbjct 438 GTLSIIAGCSSGVEPLFALCFTRNILDGERLVEINPHFEAALESGGLFSHELMDAVVAKG 497 Query 581 GVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAI 640 ++ LPA +R F TA +IAPQWHLRMQAA QRH + AVSKTVNL +AT D+R I Sbjct 498 SIQDMDYLPAPLRKTFVTAMDIAPQWHLRMQAAFQRHTDNAVSKTVNLSNSATEQDIREI 557 Query 641 YVAAWKAKVKGITVYRYGSREGQVLSYAAPKPLLAQADTEFSGGCA 686 Y A++ KG+TVYR G + QVL+ + + E +GG A Sbjct 558 YWLAYQEGCKGVTVYRDGCKSIQVLATGEGQKKMDSGSAEVAGGSA 603 >gi|289579197|ref|YP_003477824.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermoanaerobacter italicus Ab9] gi|289528910|gb|ADD03262.1| ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent [Thermoanaerobacter italicus Ab9] Length=770 Score = 571 bits (1471), Expect = 2e-160, Method: Compositional matrix adjust. Identities = 286/567 (51%), Positives = 397/567 (71%), Gaps = 8/567 (1%) Query 107 LKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSS-RRWAERFA 165 +K++ A VL RYL DE G+P E+ E+ +R AR +A + Y+ + +RF Sbjct 1 MKITENAKKVLERRYLAKDENGKPIETVEEMFERVARTIAEVDLIYDKNADVEAVKKRFY 60 Query 166 TLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYA 225 ++ +L+FLPNSPTLMN+G LG L+ CFVLP+ DS++ IF + AA + ++GGGTG++ Sbjct 61 DMMVDLDFLPNSPTLMNAGRPLGQLSACFVLPVGDSMEEIFDAVKYAAIIHKSGGGTGFS 120 Query 226 FSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFV 285 FS LRP G V +TGG ASGPVSF++++++A V GG RRGA M +L V HPDI +F+ Sbjct 121 FSRLRPKGATVRTTGGVASGPVSFMKVFNAATEAVKQGGTRRGANMGILRVDHPDILEFI 180 Query 286 TAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAA 345 K ++ +E+ +FN+SV +T+ F++AVE + + L++P TGK+ R+ A E+FD I + A Sbjct 181 QCKKDN-NEITNFNISVAITEEFMKAVEEDRKYDLIDPHTGKVTNRLRAREVFDLIVEMA 239 Query 346 HAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARML--ADGR 403 G+PG+VFLD IN NP P G IE+TNPCGE PLLPYESCNLGSINL ML +GR Sbjct 240 WRNGEPGIVFLDRINEKNPTPEVGEIESTNPCGEQPLLPYESCNLGSINLENMLKKVEGR 299 Query 404 --VDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIP 461 +D+D+L+E AV FLD+VID ++YP P++ E + TRKIGLGVMG A +L LGIP Sbjct 300 YEIDYDKLKETVYDAVHFLDNVIDANKYPLPQIEEMTKGTRKIGLGVMGFANMLLRLGIP 359 Query 462 YDSEEAVRLATRLMRRIQQAAHTASRRLAEERGAFPAFTDSRFARSGPR-RNAQVTSVAP 520 YDS+EAV L LM I + + AS +LAE+RG F + S + ++G + RNA T++AP Sbjct 360 YDSDEAVELGEELMEFIDKTSKEASIKLAEKRGTFGFYDKSIYKKTGIKIRNATTTTIAP 419 Query 521 TGTISLIAGTTAGIEPMFAIAFTRAIV-GRHLLEVNPCFDRLARDRGFYRDELIAEIAQR 579 TGTIS+IAGT++GIEP+FAIA TR ++ L+EVNP F ++A +RGFY DEL+ EIAQ+ Sbjct 420 TGTISIIAGTSSGIEPVFAIAMTRNVMDNTQLVEVNPVFKKVAIERGFYSDELMREIAQK 479 Query 580 GGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRA 639 G ++ +P +V+ F A +I P+WH++MQAA Q+HV+ AVSKTVN ATV+DVR Sbjct 480 GSLKDIKGIPEDVKRVFVIAHDIDPEWHVKMQAAFQKHVDNAVSKTVNFRNEATVEDVRR 539 Query 640 IYVAAWKAKVKGITVYRYGSREGQVLS 666 Y+ A+K KG+T+YR GSRE QVL+ Sbjct 540 TYLLAYKLGCKGVTIYRDGSRESQVLN 566 Lambda K H 0.321 0.136 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1624710204890 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40