BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv0602c

Length=253
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|15607742|ref|NP_215116.1|  two component DNA binding transcrip...   499    2e-139
gi|31791784|ref|NP_854277.1|  putative two component DNA binding ...   498    3e-139
gi|289446155|ref|ZP_06435899.1|  two component system transcripti...   497    6e-139
gi|289752642|ref|ZP_06512020.1|  two component DNA binding transc...   497    6e-139
gi|15840004|ref|NP_335041.1|  DNA-binding response regulator TcrA...   489    2e-136
gi|289568536|ref|ZP_06448763.1|  LOW QUALITY PROTEIN: two compone...   466    1e-129
gi|308231597|ref|ZP_07663887.1|  two component system transcripti...   462    3e-128
gi|1408184|gb|AAB03659.1|  two component response regulator [Myco...   456    2e-126
gi|339297285|gb|AEJ49395.1|  two component system transcriptional...   456    2e-126
gi|339293643|gb|AEJ45754.1|  two component system transcriptional...   455    4e-126
gi|289756681|ref|ZP_06516059.1|  LOW QUALITY PROTEIN: two compone...   407    6e-112
gi|167969026|ref|ZP_02551303.1|  putative two component DNA bindi...   387    7e-106
gi|289760722|ref|ZP_06520100.1|  two component system DNA binding...   322    4e-86 
gi|170783570|ref|YP_001740087.1|  CheY-like response regulator [A...   276    3e-72 
gi|284041764|ref|YP_003392104.1|  two component transcriptional r...   275    6e-72 
gi|86741097|ref|YP_481497.1|  two component transcriptional regul...   258    8e-67 
gi|336179326|ref|YP_004584701.1|  winged helix family two compone...   253    2e-65 
gi|158315649|ref|YP_001508157.1|  two component transcriptional r...   252    4e-65 
gi|312197790|ref|YP_004017851.1|  transcriptional regulator [Fran...   249    3e-64 
gi|288918433|ref|ZP_06412785.1|  two component transcriptional re...   247    1e-63 
gi|111223230|ref|YP_714024.1|  putative response regulator in two...   240    2e-61 
gi|297160739|gb|ADI10451.1|  two component transcriptional regula...   234    9e-60 
gi|345014913|ref|YP_004817267.1|  winged helix family two compone...   231    7e-59 
gi|160902317|ref|YP_001567898.1|  two component transcriptional r...   228    8e-58 
gi|119715834|ref|YP_922799.1|  response regulator receiver [Nocar...   227    1e-57 
gi|333979455|ref|YP_004517400.1|  winged helix family two compone...   227    1e-57 
gi|269797012|ref|YP_003316467.1|  CheY-like receiver domain/winge...   226    2e-57 
gi|256371502|ref|YP_003109326.1|  winged helix family two compone...   225    5e-57 
gi|95928481|ref|ZP_01311228.1|  two component transcriptional reg...   224    6e-57 
gi|119715849|ref|YP_922814.1|  response regulator receiver [Nocar...   224    6e-57 
gi|83590322|ref|YP_430331.1|  two component transcriptional regul...   224    1e-56 
gi|340793672|ref|YP_004759135.1|  two-component system response r...   223    3e-56 
gi|77920671|ref|YP_358486.1|  two component signal transduction r...   222    4e-56 
gi|326383367|ref|ZP_08205054.1|  putative OmpR family two-compone...   221    1e-55 
gi|345012352|ref|YP_004814706.1|  winged helix family two compone...   220    1e-55 
gi|254387744|ref|ZP_05002982.1|  two-component system response re...   220    2e-55 
gi|271964907|ref|YP_003339103.1|  response regulator receiver pro...   220    2e-55 
gi|283797521|ref|ZP_06346674.1|  transcriptional activator protei...   218    7e-55 
gi|342858651|ref|ZP_08715306.1|  TcrA protein [Mycobacterium colo...   217    1e-54 
gi|304317403|ref|YP_003852548.1|  transcriptional regulator [Ther...   217    1e-54 
gi|114778428|ref|ZP_01453273.1|  response regulator receiver doma...   217    1e-54 
gi|298249466|ref|ZP_06973270.1|  two component transcriptional re...   217    1e-54 
gi|118464519|ref|YP_882587.1|  TcrA protein [Mycobacterium avium ...   217    1e-54 
gi|167745896|ref|ZP_02418023.1|  hypothetical protein ANACAC_0059...   217    2e-54 
gi|295090875|emb|CBK76982.1|  Response regulators consisting of a...   216    2e-54 
gi|254775852|ref|ZP_05217368.1|  TcrA [Mycobacterium avium subsp....   216    2e-54 
gi|39995559|ref|NP_951510.1|  DNA-binding response regulator [Geo...   216    3e-54 
gi|41407200|ref|NP_960036.1|  TcrA [Mycobacterium avium subsp. pa...   216    3e-54 
gi|271961705|ref|YP_003335901.1|  response regulator receiver pro...   215    4e-54 
gi|119715846|ref|YP_922811.1|  two component transcriptional regu...   215    4e-54 


>gi|15607742|ref|NP_215116.1| two component DNA binding transcriptional regulatory protein 
TCRA [Mycobacterium tuberculosis H37Rv]
 gi|148660372|ref|YP_001281895.1| putative two component DNA binding transcriptional regulatory 
protein TcrA [Mycobacterium tuberculosis H37Ra]
 gi|148821804|ref|YP_001286558.1| two component system DNA binding transcriptional regulatory protein 
tcrA [Mycobacterium tuberculosis F11]
 33 more sequence titles
 Length=253

 Score =  499 bits (1284),  Expect = 2e-139, Method: Compositional matrix adjust.
 Identities = 252/253 (99%), Positives = 253/253 (100%), Gaps = 0/253 (0%)

Query  1    VADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60
            +ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA
Sbjct  1    MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60

Query  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120
            AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
Sbjct  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120

Query  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180
            LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
Sbjct  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180

Query  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240
            EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
Sbjct  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240

Query  241  RLRKDGGRHALPR  253
            RLRKDGGRHALPR
Sbjct  241  RLRKDGGRHALPR  253


>gi|31791784|ref|NP_854277.1| putative two component DNA binding transcriptional regulatory 
protein TCRA [Mycobacterium bovis AF2122/97]
 gi|121636520|ref|YP_976743.1| putative two component DNA binding transcriptional regulatory 
protein tcrA [Mycobacterium bovis BCG str. Pasteur 1173P2]
 gi|224988992|ref|YP_002643679.1| putative two component DNA binding transcriptional regulatory 
protein [Mycobacterium bovis BCG str. Tokyo 172]
 gi|31617371|emb|CAD93480.1| PUTATIVE TWO COMPONENT DNA BINDING TRANSCRIPTIONAL REGULATORY 
PROTEIN TCRA [Mycobacterium bovis AF2122/97]
 gi|121492167|emb|CAL70633.1| Putative two component DNA binding Transcriptional regulatory 
protein tcrA [Mycobacterium bovis BCG str. Pasteur 1173P2]
 gi|224772105|dbj|BAH24911.1| putative two component DNA binding transcriptional regulatory 
protein [Mycobacterium bovis BCG str. Tokyo 172]
 gi|341600536|emb|CCC63206.1| putative two component DNA binding Transcriptional regulatory 
protein tcrA [Mycobacterium bovis BCG str. Moreau RDJ]
Length=253

 Score =  498 bits (1283),  Expect = 3e-139, Method: Compositional matrix adjust.
 Identities = 251/253 (99%), Positives = 253/253 (100%), Gaps = 0/253 (0%)

Query  1    VADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60
            +ADETTMRAGRGPGRACGRVSGVRILV+EDEPKMTALLARALTEEGHTVDTVADGRHAVA
Sbjct  1    MADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60

Query  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120
            AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
Sbjct  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120

Query  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180
            LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
Sbjct  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180

Query  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240
            EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
Sbjct  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240

Query  241  RLRKDGGRHALPR  253
            RLRKDGGRHALPR
Sbjct  241  RLRKDGGRHALPR  253


>gi|289446155|ref|ZP_06435899.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis CPHL_A]
 gi|289419113|gb|EFD16314.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis CPHL_A]
Length=253

 Score =  497 bits (1280),  Expect = 6e-139, Method: Compositional matrix adjust.
 Identities = 251/253 (99%), Positives = 252/253 (99%), Gaps = 0/253 (0%)

Query  1    VADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60
            +ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA
Sbjct  1    MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60

Query  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120
            AVD GDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
Sbjct  61   AVDSGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120

Query  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180
            LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
Sbjct  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180

Query  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240
            EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
Sbjct  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240

Query  241  RLRKDGGRHALPR  253
            RLRKDGGRHALPR
Sbjct  241  RLRKDGGRHALPR  253


>gi|289752642|ref|ZP_06512020.1| two component DNA binding transcriptional regulatory protein 
TCRA [Mycobacterium tuberculosis EAS054]
 gi|289693229|gb|EFD60658.1| two component DNA binding transcriptional regulatory protein 
TCRA [Mycobacterium tuberculosis EAS054]
Length=253

 Score =  497 bits (1280),  Expect = 6e-139, Method: Compositional matrix adjust.
 Identities = 251/253 (99%), Positives = 252/253 (99%), Gaps = 0/253 (0%)

Query  1    VADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60
            +ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMT LLARALTEEGHTVDTVADGRHAVA
Sbjct  1    MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTVLLARALTEEGHTVDTVADGRHAVA  60

Query  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120
            AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
Sbjct  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120

Query  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180
            LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
Sbjct  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180

Query  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240
            EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
Sbjct  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY  240

Query  241  RLRKDGGRHALPR  253
            RLRKDGGRHALPR
Sbjct  241  RLRKDGGRHALPR  253


>gi|15840004|ref|NP_335041.1| DNA-binding response regulator TcrA [Mycobacterium tuberculosis 
CDC1551]
 gi|13880147|gb|AAK44855.1| DNA-binding response regulator TcrA [Mycobacterium tuberculosis 
CDC1551]
Length=247

 Score =  489 bits (1258),  Expect = 2e-136, Method: Compositional matrix adjust.
 Identities = 247/247 (100%), Positives = 247/247 (100%), Gaps = 0/247 (0%)

Query  7    MRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGD  66
            MRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGD
Sbjct  1    MRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGD  60

Query  67   YDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFN  126
            YDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFN
Sbjct  61   YDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFN  120

Query  127  LDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRR  186
            LDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRR
Sbjct  121  LDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRR  180

Query  187  PGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
            PGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG
Sbjct  181  PGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  240

Query  247  GRHALPR  253
            GRHALPR
Sbjct  241  GRHALPR  247


>gi|289568536|ref|ZP_06448763.1| LOW QUALITY PROTEIN: two component system transcriptional regulator 
tcrA [Mycobacterium tuberculosis T17]
 gi|289542290|gb|EFD45938.1| LOW QUALITY PROTEIN: two component system transcriptional regulator 
tcrA [Mycobacterium tuberculosis T17]
Length=237

 Score =  466 bits (1199),  Expect = 1e-129, Method: Compositional matrix adjust.
 Identities = 235/236 (99%), Positives = 236/236 (100%), Gaps = 0/236 (0%)

Query  1    VADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60
            +ADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA
Sbjct  1    MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA  60

Query  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120
            AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
Sbjct  61   AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY  120

Query  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180
            LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
Sbjct  121  LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL  180

Query  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIR  236
            EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIR
Sbjct  181  EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIR  236


>gi|308231597|ref|ZP_07663887.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis SUMu001]
 gi|308369995|ref|ZP_07666840.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis SUMu002]
 gi|308370458|ref|ZP_07666935.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis SUMu003]
 22 more sequence titles
 Length=234

 Score =  462 bits (1188),  Expect = 3e-128, Method: Compositional matrix adjust.
 Identities = 233/234 (99%), Positives = 234/234 (100%), Gaps = 0/234 (0%)

Query  20   VSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGI  79
            +SGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGI
Sbjct  1    MSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGI  60

Query  80   DGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSR  139
            DGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSR
Sbjct  61   DGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSR  120

Query  140  RGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLER  199
            RGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLER
Sbjct  121  RGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLER  180

Query  200  CWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  253
            CWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR
Sbjct  181  CWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  234


>gi|1408184|gb|AAB03659.1| two component response regulator [Mycobacterium tuberculosis 
str. Erdman]
Length=234

 Score =  456 bits (1173),  Expect = 2e-126, Method: Compositional matrix adjust.
 Identities = 229/234 (98%), Positives = 231/234 (99%), Gaps = 0/234 (0%)

Query  20   VSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGI  79
            +SGV ILVVEDEPKMTALLARALTEEGHTVDTVADGRH VA+VDGGDYDAVVLDVMLPGI
Sbjct  1    MSGVHILVVEDEPKMTALLARALTEEGHTVDTVADGRHTVASVDGGDYDAVVLDVMLPGI  60

Query  80   DGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSR  139
            DGFEVCARLRRQRVWTPVLMLTARGA TDRIAGLDGGADDYLTKPFNLDELFARLRALSR
Sbjct  61   DGFEVCARLRRQRVWTPVLMLTARGAFTDRIAGLDGGADDYLTKPFNLDELFARLRALSR  120

Query  140  RGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLER  199
            RGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLER
Sbjct  121  RGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLER  180

Query  200  CWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  253
            CWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR
Sbjct  181  CWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  234


>gi|339297285|gb|AEJ49395.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis CCDC5180]
Length=231

 Score =  456 bits (1172),  Expect = 2e-126, Method: Compositional matrix adjust.
 Identities = 230/231 (99%), Positives = 231/231 (100%), Gaps = 0/231 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF
Sbjct  1    MRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP
Sbjct  61   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD
Sbjct  121  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  253
            AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR
Sbjct  181  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  231


>gi|339293643|gb|AEJ45754.1| two component system transcriptional regulator tcrA [Mycobacterium 
tuberculosis CCDC5079]
Length=231

 Score =  455 bits (1170),  Expect = 4e-126, Method: Compositional matrix adjust.
 Identities = 229/231 (99%), Positives = 231/231 (100%), Gaps = 0/231 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF
Sbjct  1    MRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP
Sbjct  61   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            IPRPPTLEAGDLRLDP+EHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD
Sbjct  121  IPRPPTLEAGDLRLDPNEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  253
            AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR
Sbjct  181  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  231


>gi|289756681|ref|ZP_06516059.1| LOW QUALITY PROTEIN: two component DNA binding transcriptional 
regulatory protein TCRA [Mycobacterium tuberculosis T85]
 gi|289712245|gb|EFD76257.1| LOW QUALITY PROTEIN: two component DNA binding transcriptional 
regulatory protein TCRA [Mycobacterium tuberculosis T85]
Length=211

 Score =  407 bits (1047),  Expect = 6e-112, Method: Compositional matrix adjust.
 Identities = 205/205 (100%), Positives = 205/205 (100%), Gaps = 0/205 (0%)

Query  49   VDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTD  108
            VDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTD
Sbjct  7    VDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTD  66

Query  109  RIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADT  168
            RIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADT
Sbjct  67   RIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADT  126

Query  169  EIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFG  228
            EIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFG
Sbjct  127  EIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFG  186

Query  229  VTSLETIRGAGYRLRKDGGRHALPR  253
            VTSLETIRGAGYRLRKDGGRHALPR
Sbjct  187  VTSLETIRGAGYRLRKDGGRHALPR  211


>gi|167969026|ref|ZP_02551303.1| putative two component DNA binding Transcriptional regulatory 
protein tcrA [Mycobacterium tuberculosis H37Ra]
Length=195

 Score =  387 bits (995),  Expect = 7e-106, Method: Compositional matrix adjust.
 Identities = 194/195 (99%), Positives = 195/195 (100%), Gaps = 0/195 (0%)

Query  59   VAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGAD  118
            +AAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGAD
Sbjct  1    MAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGAD  60

Query  119  DYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFT  178
            DYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFT
Sbjct  61   DYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFT  120

Query  179  LLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGA  238
            LLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGA
Sbjct  121  LLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGA  180

Query  239  GYRLRKDGGRHALPR  253
            GYRLRKDGGRHALPR
Sbjct  181  GYRLRKDGGRHALPR  195


>gi|289760722|ref|ZP_06520100.1| two component system DNA binding transcriptional regulatory protein 
[Mycobacterium tuberculosis GM 1503]
 gi|289708228|gb|EFD72244.1| two component system DNA binding transcriptional regulatory protein 
[Mycobacterium tuberculosis GM 1503]
Length=161

 Score =  322 bits (824),  Expect = 4e-86, Method: Compositional matrix adjust.
 Identities = 160/161 (99%), Positives = 161/161 (100%), Gaps = 0/161 (0%)

Query  93   VWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAG  152
            +WTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAG
Sbjct  1    MWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAG  60

Query  153  DLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIV  212
            DLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIV
Sbjct  61   DLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIV  120

Query  213  DVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  253
            DVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR
Sbjct  121  DVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR  161


>gi|170783570|ref|YP_001740087.1| CheY-like response regulator [Arthrobacter sp. Chr15]
 gi|150035078|gb|ABR67074.1| CheY-like response regulator [Arthrobacter sp. Chr15]
Length=247

 Score =  276 bits (705),  Expect = 3e-72, Method: Compositional matrix adjust.
 Identities = 141/228 (62%), Positives = 166/228 (73%), Gaps = 0/228 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            VR+LVVEDEPKM  LL R L EEG+ VD  AD    ++A  GG YDAVVLDVMLPG  GF
Sbjct  17   VRVLVVEDEPKMAGLLRRGLAEEGYAVDVAADSPAGLSAASGGGYDAVVLDVMLPGFPGF  76

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            E+C RLR + +  PVLMLTAR AV DR+ GLD GADDYL KPF+L+EL ARLRAL+RRGP
Sbjct  77   ELCRRLRERGIEVPVLMLTARDAVDDRVRGLDSGADDYLAKPFHLEELLARLRALTRRGP  136

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            +     L AG+LRLD    R WR + E+ L+ KE  LLE  + +PG V TR  LLE CWD
Sbjct  137  LVSARGLVAGNLRLDSEGMRCWRGEAEVNLTAKEHALLEFFMEQPGRVLTREVLLENCWD  196

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHA  250
             A+EA SN+VDV++R LR+KIDR FGV S+ET+RG GYRLR D GR A
Sbjct  197  LAFEANSNVVDVHVRALREKIDRRFGVRSIETVRGVGYRLRADAGRRA  244


>gi|284041764|ref|YP_003392104.1| two component transcriptional regulator [Conexibacter woesei 
DSM 14684]
 gi|283945985|gb|ADB48729.1| two component transcriptional regulator, winged helix family 
[Conexibacter woesei DSM 14684]
Length=226

 Score =  275 bits (702),  Expect = 6e-72, Method: Compositional matrix adjust.
 Identities = 139/226 (62%), Positives = 166/226 (74%), Gaps = 0/226 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LV+EDEPK+ A + R LTE+G   D    G  A+       YDA+VLDVMLPGIDGF
Sbjct  1    MRVLVIEDEPKLRAAIRRGLTEDGLVCDVAERGEDALWMAGSSAYDAIVLDVMLPGIDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            E C RLR   VW PVLMLTAR AV DR+AGLD GADDY+TKPF+L EL ARLRAL+RRGP
Sbjct  61   ETCRRLRADGVWAPVLMLTARDAVEDRVAGLDTGADDYVTKPFSLAELSARLRALARRGP  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            + RP  L AGDL LDP+  RV R + EI LS +E+ LLEA +RRPG V  R  LL+  W 
Sbjct  121  VQRPAVLAAGDLTLDPATRRVARGEVEIELSAREYALLEAFMRRPGEVLERHVLLDLAWG  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGR  248
              YE RSN+VDVY+RYLR+++DRPFG  ++ET+RG GYRLR DGGR
Sbjct  181  RDYENRSNVVDVYVRYLRERVDRPFGAEAIETLRGVGYRLRADGGR  226


>gi|86741097|ref|YP_481497.1| two component transcriptional regulator [Frankia sp. CcI3]
 gi|86567959|gb|ABD11768.1| two component transcriptional regulator, winged helix family 
[Frankia sp. CcI3]
Length=283

 Score =  258 bits (658),  Expect = 8e-67, Method: Compositional matrix adjust.
 Identities = 140/238 (59%), Positives = 163/238 (69%), Gaps = 4/238 (1%)

Query  10   GRGPGRACGRVSG----VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGG  65
            GR P R C R S     +R+LVVEDE +  ALL R L EEG+ VD V DG  AV      
Sbjct  13   GRRPERFCARSSSTIRSMRVLVVEDEARTAALLRRGLVEEGYAVDVVGDGADAVWQATEI  72

Query  66   DYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPF  125
             YDA+VLD+MLPG+DGFEVC RLR    W PVLMLTARG V DRI GLD GADDYL KPF
Sbjct  73   GYDAIVLDLMLPGLDGFEVCRRLREAGRWAPVLMLTARGDVDDRIRGLDAGADDYLPKPF  132

Query  126  NLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIR  185
            +  EL ARLRAL RRG + RP  L  GDLRLDP+EHRV RA + + LS KEF LL  L+R
Sbjct  133  SFGELTARLRALVRRGAVERPTVLRIGDLRLDPAEHRVLRAGSPLDLSAKEFALLHLLMR  192

Query  186  RPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLR  243
             P  V TR  +++  WD A++  SNIVD Y+RY+R KID P G + +ET+RG GYRLR
Sbjct  193  HPDEVLTRTYIVDHVWDFAFDGTSNIVDQYVRYVRRKIDIPDGPSLIETVRGVGYRLR  250


>gi|336179326|ref|YP_004584701.1| winged helix family two component transcriptional regulator [Frankia 
symbiont of Datisca glomerata]
 gi|334860306|gb|AEH10780.1| two component transcriptional regulator, winged helix family 
[Frankia symbiont of Datisca glomerata]
Length=229

 Score =  253 bits (645),  Expect = 2e-65, Method: Compositional matrix adjust.
 Identities = 133/220 (61%), Positives = 154/220 (70%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE +   LL R LTEEG  VD VADG  AV       YD +VLD+MLPG+DGF
Sbjct  1    MRVLVVEDETRTATLLRRGLTEEGFAVDIVADGLEAVWQASEIAYDVIVLDLMLPGLDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVC RLR    W PVLML+AR  VTDR+ GLD GADDYL KPF+ DELFAR+RAL RRG 
Sbjct  61   EVCRRLRAAGRWAPVLMLSARSEVTDRVRGLDVGADDYLAKPFSFDELFARIRALIRRGT  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L+   LRLDP+     R  T + LS KEF LLE L+R PG V +R  +LE  WD
Sbjct  121  HERPVVLDVDGLRLDPAGRTASRDGTALDLSPKEFALLEYLMRHPGEVLSRTAILEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
             AY+  SN+VD YI YLR KIDRPFG++ LET+RGAGYRL
Sbjct  181  FAYDGTSNVVDQYIAYLRRKIDRPFGISQLETVRGAGYRL  220


>gi|158315649|ref|YP_001508157.1| two component transcriptional regulator [Frankia sp. EAN1pec]
 gi|158111054|gb|ABW13251.1| two component transcriptional regulator, winged helix family 
[Frankia sp. EAN1pec]
Length=235

 Score =  252 bits (643),  Expect = 4e-65, Method: Compositional matrix adjust.
 Identities = 132/221 (60%), Positives = 158/221 (72%), Gaps = 0/221 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE +   LL R LTE G+ VD V DG  AV       YDA+VLD+MLPG+DGF
Sbjct  1    MRVLVVEDEERTADLLRRGLTEAGYAVDLVHDGTDAVWQAGEISYDAIVLDLMLPGLDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVC RLR  R W+P+LMLTARG V DRI GLD GADDYL KPF+  EL ARLRAL RRG 
Sbjct  61   EVCRRLRAARRWSPILMLTARGDVDDRIHGLDAGADDYLAKPFSFGELTARLRALIRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            + RP TL  GD+ LDP+   V RA   + LS KEF+LLE L+RRPG V TR+ +L+  WD
Sbjct  121  VERPATLRVGDIHLDPAARSVQRAGEPVDLSAKEFSLLELLMRRPGEVLTRSYILDHMWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLR  243
              Y+  SN+VD Y+RYLR KID   G++ +ET+RGAGYRLR
Sbjct  181  LGYDGTSNVVDQYVRYLRRKIDPADGLSRIETVRGAGYRLR  221


>gi|312197790|ref|YP_004017851.1| transcriptional regulator [Frankia sp. EuI1c]
 gi|311229126|gb|ADP81981.1| two component transcriptional regulator, winged helix family 
[Frankia sp. EuI1c]
Length=229

 Score =  249 bits (636),  Expect = 3e-64, Method: Compositional matrix adjust.
 Identities = 132/221 (60%), Positives = 153/221 (70%), Gaps = 0/221 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDEP+  ALL R L EEG  VD VADG  AV       YD +VLD+MLP +DGF
Sbjct  1    MRVLVVEDEPRTAALLRRGLAEEGFAVDVVADGGDAVWQASEITYDVIVLDLMLPVLDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVC RLR    W PVLML+ARG V DR+ GLD GADDYL KPF+ DEL ARLRAL RRG 
Sbjct  61   EVCRRLRAAERWAPVLMLSARGEVVDRVRGLDVGADDYLGKPFSFDELSARLRALIRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L+   LRLDP+     R   E+ LS KEF LLE L+R PG V +R  +L+  WD
Sbjct  121  QERPVVLDIDGLRLDPTVRAASRDGVELDLSPKEFALLEYLMRHPGQVLSRTTILDHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLR  243
             AY+  SN+VD Y+ YLR KID+PFGV  LET+RGAGYRLR
Sbjct  181  LAYDRNSNVVDQYVAYLRRKIDKPFGVAQLETVRGAGYRLR  221


>gi|288918433|ref|ZP_06412785.1| two component transcriptional regulator, winged helix family 
[Frankia sp. EUN1f]
 gi|288350196|gb|EFC84421.1| two component transcriptional regulator, winged helix family 
[Frankia sp. EUN1f]
Length=227

 Score =  247 bits (631),  Expect = 1e-63, Method: Compositional matrix adjust.
 Identities = 132/221 (60%), Positives = 153/221 (70%), Gaps = 0/221 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE +  ALL R L EEG  VD VADG  AV       YD +VLD+MLP +DGF
Sbjct  1    MRVLVVEDETRTAALLRRGLAEEGFAVDVVADGADAVWQATEITYDVIVLDLMLPSLDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVC RLR    W+PVLML+ARGAVTDR+ GLD GADDYL KPF+ DEL AR+RAL RRG 
Sbjct  61   EVCRRLRAAGRWSPVLMLSARGAVTDRVRGLDVGADDYLPKPFSFDELSARIRALIRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  LE   LRLDP+   V R    + LS KEF LLE L+R PG    R  +LE  WD
Sbjct  121  HERPVVLEVDGLRLDPAGRTVSRDGVPLDLSPKEFALLEYLMRHPGEALRRTAILEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLR  243
             AY+  SN+VD Y+ YLR KID+PFG + LET+RGAGYRLR
Sbjct  181  FAYDGTSNVVDQYVAYLRRKIDKPFGTSQLETVRGAGYRLR  221


>gi|111223230|ref|YP_714024.1| putative response regulator in two-component regulatory system 
[Frankia alni ACN14a]
 gi|111150762|emb|CAJ62464.1| putative response regulator in two-component regulatory system 
[Frankia alni ACN14a]
Length=246

 Score =  240 bits (612),  Expect = 2e-61, Method: Compositional matrix adjust.
 Identities = 130/220 (60%), Positives = 150/220 (69%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE +  A+L R L EEG+ VD V DG  AV       YDA+VLD+MLPGIDGF
Sbjct  1    MRVLVVEDEVRTAAVLRRGLVEEGYAVDVVGDGIDAVWRATEIAYDAIVLDLMLPGIDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVC RLR    W PVLMLTAR  V DRI GLD GADDYL KPF+  EL ARLRAL RRG 
Sbjct  61   EVCRRLRAGHRWAPVLMLTARVDVDDRIRGLDAGADDYLPKPFSFGELTARLRALVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            + RP  L AG + LDP+ HRVWR    + LS KEF LL  L+R P  V TR  + E  WD
Sbjct  121  VHRPVVLRAGAVELDPAGHRVWRGGEPVDLSAKEFALLHLLLRHPDQVLTRTYITEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
             A++A SNIVD Y+RYLR KID P   + +ET+RG GYRL
Sbjct  181  DAFDATSNIVDQYVRYLRRKIDLPPAPSLIETVRGVGYRL  220


>gi|297160739|gb|ADI10451.1| two component transcriptional regulator, winged helix family 
protein [Streptomyces bingchenggensis BCW-1]
Length=225

 Score =  234 bits (597),  Expect = 9e-60, Method: Compositional matrix adjust.
 Identities = 120/225 (54%), Positives = 155/225 (69%), Gaps = 0/225 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVED+ ++  LL   L +EG TV+T  DGR  +A   G +Y A+VLDVMLPG+ G+
Sbjct  1    MRILVVEDDARLRELLKEGLEQEGFTVETAGDGRDGLALARGTEYAAIVLDVMLPGLSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            +VC+RLR   VWTP+LMLTA+    D   GLD GADDYLTKPF+   L AR+RAL RRG 
Sbjct  61   QVCSRLREAGVWTPILMLTAKDGEYDEADGLDVGADDYLTKPFSYVVLIARVRALVRRGG  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            + RP  LE GDLRL+P+     R +  I L+ KEF +LE L RR G V ++ +++   WD
Sbjct  121  LDRPEVLELGDLRLEPTALACSRGNEGITLTAKEFAVLECLARRAGQVVSKTEIVHTVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGG  247
             AYE  +N+V+VYIR LR KID P+G  ++ TIRGAGY L +DGG
Sbjct  181  TAYEGGANLVEVYIRTLRRKIDVPYGRQAIRTIRGAGYLLARDGG  225


>gi|345014913|ref|YP_004817267.1| winged helix family two component transcriptional regulator [Streptomyces 
violaceusniger Tu 4113]
 gi|344041262|gb|AEM86987.1| two component transcriptional regulator, winged helix family 
[Streptomyces violaceusniger Tu 4113]
Length=225

 Score =  231 bits (589),  Expect = 7e-59, Method: Compositional matrix adjust.
 Identities = 117/225 (52%), Positives = 155/225 (69%), Gaps = 0/225 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVED+ ++  LL   L +EG T++T ADG   +A    G Y A+VLDVMLPG  G+
Sbjct  1    MRILVVEDDARLRELLTEGLEQEGFTIETAADGLSGLALARSGGYAAIVLDVMLPGCSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            ++C+RLR +  WTP+LMLTA+    D   GLD GADDYLTKPF+   L AR+RAL RRG 
Sbjct  61   QLCSRLREKGDWTPILMLTAKDGEYDEADGLDVGADDYLTKPFSFVVLIARVRALVRRGG  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            + RP  LE GDLRL+P+     R   E+ L+ KEF +LE L RR G V +++++++  WD
Sbjct  121  LDRPDVLELGDLRLEPAALACARGKEEVTLTAKEFAVLEYLARRAGQVVSKSEIVQSVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGG  247
             AY+  +N+V+VYIR LR KID P+G  S+ TIRGAGY L +DGG
Sbjct  181  TAYDGGANLVEVYIRSLRRKIDVPYGRQSIRTIRGAGYLLARDGG  225


>gi|160902317|ref|YP_001567898.1| two component transcriptional regulator [Petrotoga mobilis SJ95]
 gi|160359961|gb|ABX31575.1| two component transcriptional regulator, winged helix family 
[Petrotoga mobilis SJ95]
Length=222

 Score =  228 bits (580),  Expect = 8e-58, Method: Compositional matrix adjust.
 Identities = 110/220 (50%), Positives = 146/220 (67%), Gaps = 1/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            ++ILVVEDE K+  ++ R LTEEG+ +D V DG  A        YD ++LD+MLP  DG 
Sbjct  1    MKILVVEDEEKLAYIIKRGLTEEGYCIDVVYDGEEAENYAKYSSYDLIILDIMLPKKDGI  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             VC  +R++ + TP+LMLTA+ +V DR+ GLD GADDYL KPF+ DELFAR+R+L RR  
Sbjct  61   TVCQNIRKENINTPILMLTAKDSVGDRVKGLDSGADDYLVKPFDFDELFARVRSLLRRES  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              R P L+ GDL L+     VW  + +++L+ KE+ +LE  +R P IV TR  L E+ WD
Sbjct  121  FTRNPVLKVGDLTLNTLTREVWMGEKKLKLTPKEYNILEYFMRNPKIVVTRTILEEKMWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
              +E  SN++DVYIR LR KI    G   LET+RGAGYRL
Sbjct  181  IDFEGNSNVIDVYIRRLRKKIGDKEG-KILETVRGAGYRL  219


>gi|119715834|ref|YP_922799.1| response regulator receiver [Nocardioides sp. JS614]
 gi|119536495|gb|ABL81112.1| response regulator receiver [Nocardioides sp. JS614]
Length=226

 Score =  227 bits (579),  Expect = 1e-57, Method: Compositional matrix adjust.
 Identities = 116/221 (53%), Positives = 146/221 (67%), Gaps = 0/221 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE ++ A L   L  EG  VD  ADG  A+   +   YD ++LDVMLP ++G+
Sbjct  1    MRVLVVEDEARLAASLKAGLEAEGFAVDVAADGGEALWYAEETSYDVILLDVMLPVLNGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EVC RLR + VWTP+LMLTAR    D I GLD GADDY+TKPF+ D L AR+R+L RRG 
Sbjct  61   EVCRRLREREVWTPILMLTARDEELDEIEGLDQGADDYVTKPFSFDILLARIRSLVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  LE GDLR DP+   V RA   I L+ +E  L+   +RR G V T+ ++LE  WD
Sbjct  121  TERPTILEVGDLRYDPARKAVSRAGQPIDLTSRELALMAFFMRRAGDVLTKLEILENVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLR  243
             A+E   NIV+VY+  LR K+D+PFG   LET RG GYRLR
Sbjct  181  FAFEGDPNIVEVYVGRLRRKVDKPFGCADLETFRGTGYRLR  221


>gi|333979455|ref|YP_004517400.1| winged helix family two component transcriptional regulator [Desulfotomaculum 
kuznetsovii DSM 6115]
 gi|333822936|gb|AEG15599.1| two component transcriptional regulator, winged helix family 
[Desulfotomaculum kuznetsovii DSM 6115]
Length=226

 Score =  227 bits (578),  Expect = 1e-57, Method: Compositional matrix adjust.
 Identities = 121/224 (55%), Positives = 146/224 (66%), Gaps = 0/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVEDE  +   LAR L EEG+  D   DG   +A  +  DYD ++LD+MLP +DG 
Sbjct  1    MRILVVEDETTLANTLARCLREEGYATDIAYDGEEGIAFAETVDYDLIILDLMLPRLDGM  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV  RLR +R+ TPVLMLTAR  V D++ GLD GADDYLTKPF L EL AR+RAL RR  
Sbjct  61   EVIRRLRNERIDTPVLMLTARDTVADKVRGLDAGADDYLTKPFALAELLARVRALLRRES  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              +   L+ GDL +D    RV R D EI L++KE  LLE L+R P  V TR Q+ E  WD
Sbjct  121  ANKSTVLQVGDLVMDTVSRRVRRGDREINLTNKEHALLEYLMRNPNRVLTRTQIAEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
              +   SNIVDVYIRYLR KID  F    L T+RG+GY LR+ G
Sbjct  181  YDFSGMSNIVDVYIRYLRRKIDDNFEPKLLYTVRGSGYCLREPG  224


>gi|269797012|ref|YP_003316467.1| CheY-like receiver domain/winged-helix DNA-binding domain-containing 
response regulator [Sanguibacter keddieii DSM 10542]
 gi|269099197|gb|ACZ23633.1| response regulator with CheY-like receiver domain and winged-helix 
DNA-binding domain [Sanguibacter keddieii DSM 10542]
Length=225

 Score =  226 bits (577),  Expect = 2e-57, Method: Compositional matrix adjust.
 Identities = 114/220 (52%), Positives = 152/220 (70%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVV+DE ++   + R L  EG  VD  A+G   +       YDA+VLD+M+PG++G+
Sbjct  1    MRILVVDDEVRLVDGVRRGLEAEGFAVDVAANGVDGLWMAQEHRYDAIVLDIMMPGMNGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             VC RLR    WTP+LMLTA+    D++  LD GADD+L+KPF+   L ARLR+L RRG 
Sbjct  61   TVCERLRAAEDWTPILMLTAKDGEWDQVEALDTGADDFLSKPFSYAVLVARLRSLVRRGS  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  LEAGDL+LDP+  RV R D EI L+ +EF +LE LIR  G V ++ Q+L+  WD
Sbjct  121  RERPVVLEAGDLQLDPAARRVRRGDVEIELTSREFAVLEFLIRNAGDVVSKRQVLDNVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
              +E   NIV+VY+R+LR+K+DRPFG  S+ET+RGAGYRL
Sbjct  181  GDFEGDPNIVEVYVRHLRNKVDRPFGRASIETLRGAGYRL  220


>gi|256371502|ref|YP_003109326.1| winged helix family two component transcriptional regulator [Acidimicrobium 
ferrooxidans DSM 10331]
 gi|256008086|gb|ACU53653.1| two component transcriptional regulator, winged helix family 
[Acidimicrobium ferrooxidans DSM 10331]
Length=236

 Score =  225 bits (573),  Expect = 5e-57, Method: Compositional matrix adjust.
 Identities = 112/226 (50%), Positives = 145/226 (65%), Gaps = 0/226 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+V+DE  + A L R L+ EG  VDT +DG   +       YD +VLD+MLPG++GF
Sbjct  1    MRLLIVDDEENLLASLKRGLSAEGFAVDTASDGTTGLDMARHAPYDCIVLDIMLPGVNGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            +    LR +R WTP+LMLTA+    D    LD GADD L KPF+   L AR+RAL RR  
Sbjct  61   KFTQLLREERNWTPILMLTAKDGEYDEAEALDTGADDVLKKPFSFTVLVARIRALLRRNV  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
               PP L+AGDL LDP+ HRV R +  I L+ +EF+ LE L+R  G V  +  ++   WD
Sbjct  121  ESHPPILQAGDLTLDPASHRVTRGNVTIDLTTREFSFLELLLRNKGHVLRKQDIIAHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGR  248
              +E  SNIV+VYI YLR KID PFG  ++ TIRG GYRL +DGGR
Sbjct  181  YDFEGDSNIVEVYIGYLRKKIDVPFGTKAITTIRGVGYRLEEDGGR  226


>gi|95928481|ref|ZP_01311228.1| two component transcriptional regulator, winged helix family 
[Desulfuromonas acetoxidans DSM 684]
 gi|95135271|gb|EAT16923.1| two component transcriptional regulator, winged helix family 
[Desulfuromonas acetoxidans DSM 684]
Length=223

 Score =  224 bits (572),  Expect = 6e-57, Method: Compositional matrix adjust.
 Identities = 108/223 (49%), Positives = 144/223 (65%), Gaps = 0/223 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            ++ILVVEDE K+ + + R L EE  TVD  A+G   +   +   YD +++D+MLP  DG 
Sbjct  1    MKILVVEDEKKVASFIKRGLEEENFTVDIAANGEEGLYMAESNHYDLILMDIMLPKKDGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             V   LR + V TPVL LTA+ +V D +AGLD G+DDYLTKPF   EL AR++AL RRG 
Sbjct  61   TVIKELRSKEVTTPVLCLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVKALVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              R   +   DLRLDP  H+VWRAD EI L+ KE+ LLE  +R P  V TR  + E  WD
Sbjct  121  KDRGAEIYFADLRLDPVTHKVWRADKEIDLTAKEYGLLEYFMRNPNQVLTRTMIAEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
              +++ +NI+DVY+ YLR KID+ +    + TIRG GY L++D
Sbjct  181  YTFDSFTNIIDVYVNYLRKKIDKDYSKKLIHTIRGVGYVLKED  223


>gi|119715849|ref|YP_922814.1| response regulator receiver [Nocardioides sp. JS614]
 gi|119536510|gb|ABL81127.1| response regulator receiver [Nocardioides sp. JS614]
Length=225

 Score =  224 bits (572),  Expect = 6e-57, Method: Compositional matrix adjust.
 Identities = 112/224 (50%), Positives = 149/224 (67%), Gaps = 0/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+VEDE ++   ++R L  EG  VDT+ DG   +A     DYD +VLD+MLP ++G+
Sbjct  1    MRVLMVEDEVRLAETVSRGLRAEGFVVDTIHDGAEGLAEAQLRDYDVIVLDIMLPSMNGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            +VC  LR+  VW P+LMLTA+    D    LD GADDYLTKPF+   L ARLRAL RRG 
Sbjct  61   DVCRELRKAGVWVPILMLTAKDGEYDEADALDLGADDYLTKPFSFVVLVARLRALVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L  GDL LDP+   V R  TEI L+ +EF LL  L+R PG V ++  +++  WD
Sbjct  121  PKRPSVLTVGDLTLDPATRMVGRGGTEIALTPREFALLHFLMRHPGEVLSKTAIVQSVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
              Y+   N+V+VY+ YLR KID+PFG T+++T+RGAGYRL  DG
Sbjct  181  LNYDGDENVVEVYVGYLRRKIDQPFGTTTIQTMRGAGYRLLGDG  224


>gi|83590322|ref|YP_430331.1| two component transcriptional regulator [Moorella thermoacetica 
ATCC 39073]
 gi|83573236|gb|ABC19788.1| two component transcriptional regulator, winged helix family 
[Moorella thermoacetica ATCC 39073]
Length=240

 Score =  224 bits (570),  Expect = 1e-56, Method: Compositional matrix adjust.
 Identities = 121/224 (55%), Positives = 146/224 (66%), Gaps = 0/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVEDE  +   LAR L EEG+  D   DG   VA  +   YD ++LD+MLP +DG 
Sbjct  15   MRILVVEDETTLANTLARCLREEGYATDIAYDGEEGVAFAETVVYDLIILDLMLPRLDGM  74

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV  RLR +R+ TPVLMLTAR  V D++ GLD GADDYLTKPF L EL AR+RAL RR  
Sbjct  75   EVIRRLRNERIETPVLMLTARDTVADKVRGLDAGADDYLTKPFALAELLARVRALLRRES  134

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              +   L+ GDL +D    +V R D EI L++KE+ LLE L+R P  V TR Q+ E  WD
Sbjct  135  DNKSTVLQVGDLVMDTVSRQVRRGDREINLTNKEYALLEYLMRNPNRVLTRTQIAEHVWD  194

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
              +   SNIVDVYIRYLR KID  F    L TIRG+GY LR+ G
Sbjct  195  YDFSGMSNIVDVYIRYLRRKIDDNFEPKLLYTIRGSGYCLREPG  238


>gi|340793672|ref|YP_004759135.1| two-component system response regulator [Corynebacterium variabile 
DSM 44702]
 gi|340533582|gb|AEK36062.1| two-component system response regulator [Corynebacterium variabile 
DSM 44702]
Length=255

 Score =  223 bits (567),  Expect = 3e-56, Method: Compositional matrix adjust.
 Identities = 112/229 (49%), Positives = 154/229 (68%), Gaps = 0/229 (0%)

Query  19   RVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPG  78
            R++ +RILVV+DE ++   + R L  EG  VD V DG   +A     DYDA+VLDVM+PG
Sbjct  27   RLTAMRILVVDDEVRLADGVRRGLEAEGMVVDVVNDGETGLAMASDADYDAIVLDVMMPG  86

Query  79   IDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALS  138
            ++G+ VC  LR    WTPVL LTA+    D + GLD G DD+LTKPF+   L ARLRA+ 
Sbjct  87   MNGYRVCEALREDGNWTPVLFLTAKDGEWDEVEGLDTGGDDWLTKPFSYPVLVARLRAMV  146

Query  139  RRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLE  198
            RRG   RP  L AGDLRLDP+  + +R+D EI L+ +E  +L+ L+R  G V T+ ++L 
Sbjct  147  RRGSRGRPEILSAGDLRLDPAARQAYRSDDEIPLTARELAVLDFLLRHAGEVVTKQEVLA  206

Query  199  RCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGG  247
              W  +++  +NIV+VYI +LR K+DRPFG  ++ T+RGAGYRL ++GG
Sbjct  207  NVWGGSFDGDTNIVEVYIGHLRAKVDRPFGRAAIGTVRGAGYRLDRNGG  255


>gi|77920671|ref|YP_358486.1| two component signal transduction response regulator [Pelobacter 
carbinolicus DSM 2380]
 gi|77546754|gb|ABA90316.1| two component transcriptional regulator, winged helix family 
[Pelobacter carbinolicus DSM 2380]
Length=223

 Score =  222 bits (565),  Expect = 4e-56, Method: Compositional matrix adjust.
 Identities = 107/222 (49%), Positives = 143/222 (65%), Gaps = 0/222 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE K+ + + R L EE  TVD   DG   +   +   YD +++D+MLP  DG 
Sbjct  1    MRVLVVEDEKKVASFIKRGLEEEDFTVDVAFDGEEGLYLAENNPYDIILMDLMLPKKDGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV   LR + V TPVL LTA+ AV D ++GLD G+DDYLTKPF   EL AR++AL RR  
Sbjct  61   EVIKELRTKDVTTPVLCLTAKDAVEDIVSGLDSGSDDYLTKPFAFSELLARVKALLRRSA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              R   +   DLRLDP  H+VWR+D EI L+ KE+ LLE  +R P  V TRA + E  WD
Sbjct  121  KDRGAEIYFADLRLDPVSHKVWRSDQEIDLTAKEYALLEYFMRNPNQVLTRAMIAEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRK  244
              +++ +NI+DVY+ YLR K+DR F    + T+RG GY L++
Sbjct  181  YTFDSFTNIIDVYVNYLRKKVDRDFDKKLIHTVRGVGYVLKE  222


>gi|326383367|ref|ZP_08205054.1| putative OmpR family two-component response regulator [Gordonia 
neofelifaecis NRRL B-59395]
 gi|326197773|gb|EGD54960.1| putative OmpR family two-component response regulator [Gordonia 
neofelifaecis NRRL B-59395]
Length=224

 Score =  221 bits (562),  Expect = 1e-55, Method: Compositional matrix adjust.
 Identities = 111/224 (50%), Positives = 145/224 (65%), Gaps = 0/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+V+D+P +   + R L  EG  VDT  DG   +       +D VVLD+M+PG +G+
Sbjct  1    MRVLLVDDDPAIAETVRRTLVAEGWVVDTATDGLTGLQKALSEPFDVVVLDIMMPGRNGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV   LRR +VWTPVLMLTA+    D+    D GADDYLTKP++   L ARLRAL+RRG 
Sbjct  61   EVVRDLRRAQVWTPVLMLTAKDGEYDQADAFDFGADDYLTKPYSAVVLVARLRALARRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  + AG L LDPS H V R DTE+ L+ +EF LLE L+R  G   T+ Q+++  WD
Sbjct  121  PERPAVMTAGSLSLDPSAHVVKRGDTELSLTRREFALLEFLMRNKGQAVTKTQIVDSVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
              Y    N+V+VYI YLR +ID PFG  S++T+RG GYRL  DG
Sbjct  181  VNYTGDENVVEVYISYLRKRIDAPFGCKSIQTVRGVGYRLDDDG  224


>gi|345012352|ref|YP_004814706.1| winged helix family two component transcriptional regulator [Streptomyces 
violaceusniger Tu 4113]
 gi|344038701|gb|AEM84426.1| two component transcriptional regulator, winged helix family 
[Streptomyces violaceusniger Tu 4113]
Length=225

 Score =  220 bits (561),  Expect = 1e-55, Method: Compositional matrix adjust.
 Identities = 118/224 (53%), Positives = 145/224 (65%), Gaps = 0/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVED P +   L   LT EG  VD   DG   +  V    YDA+VLD+MLP ++G+
Sbjct  1    MRVLVVEDHPMLGRALVHGLTTEGFAVDLATDGAEGLYRVGETPYDAIVLDIMLPRVNGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            +VC RLR  + WTPVLMLTA+    D   GLD GADDYLTKPF+   L ARL AL RRG 
Sbjct  61   DVCRRLRAAKDWTPVLMLTAKDGEYDEADGLDIGADDYLTKPFSYVVLTARLHALIRRGH  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
            IPRPP L  GDL LDP      RA T I L+ +EF+LLE L+R  G V ++ ++L   W 
Sbjct  121  IPRPPVLSVGDLLLDPGGRTCVRAGTPIELTTREFSLLEYLVRHEGQVVSKQEILTHVWA  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
              ++   N+V+VYI YLR KID PF V S+ET+RGAGYRL  DG
Sbjct  181  EHFDLDPNVVEVYIGYLRRKIDTPFRVRSIETVRGAGYRLAADG  224


>gi|254387744|ref|ZP_05002982.1| two-component system response regulator [Streptomyces clavuligerus 
ATCC 27064]
 gi|294817993|ref|ZP_06776635.1| Two component transcriptional regulator, winged helix family 
[Streptomyces clavuligerus ATCC 27064]
 gi|326446884|ref|ZP_08221618.1| two component transcriptional regulator, winged helix family 
protein [Streptomyces clavuligerus ATCC 27064]
 gi|197701469|gb|EDY47281.1| two-component system response regulator [Streptomyces clavuligerus 
ATCC 27064]
 gi|294322808|gb|EFG04943.1| Two component transcriptional regulator, winged helix family 
[Streptomyces clavuligerus ATCC 27064]
Length=226

 Score =  220 bits (560),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 116/224 (52%), Positives = 148/224 (67%), Gaps = 1/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVED+P++  LL R L  EG  VD   DG HA+      +YDA+VLDVMLPG++G 
Sbjct  1    MRILVVEDDPRLMELLCRGLGGEGFAVDGTGDGAHALELAQENEYDAIVLDVMLPGMNGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             VCARLR  R+WTPVLMLTAR    D   GLD GADDY+TKPF+   L ARLRAL RRG 
Sbjct  61   RVCARLRENRIWTPVLMLTARDGEYDEAEGLDTGADDYVTKPFSYIALVARLRALVRRGR  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RPP +E GDLR+DP+  R  R+ T + L+ +EF +L  L  + G V  + ++L+  W 
Sbjct  121  RERPPVIEIGDLRVDPATRRCERSGTPVPLTAREFGVLWYLAAQRGEVVAKTEILDHVW-  179

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDG  246
              +E   N+V+VY+  LR KID PFG  ++ T+RGAGYRL   G
Sbjct  180  GDFEGDVNVVEVYVSALRRKIDTPFGRRTIHTVRGAGYRLEDTG  223


>gi|271964907|ref|YP_003339103.1| response regulator receiver protein [Streptosporangium roseum 
DSM 43021]
 gi|270508082|gb|ACZ86360.1| response regulator receiver protein [Streptosporangium roseum 
DSM 43021]
Length=224

 Score =  220 bits (560),  Expect = 2e-55, Method: Compositional matrix adjust.
 Identities = 117/225 (52%), Positives = 148/225 (66%), Gaps = 1/225 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+LVVEDE +M A L R L  EG  VD   DG   +     GDYD VVLD+MLP + G+
Sbjct  1    MRVLVVEDERRMAAALQRGLQAEGFAVDLAHDGEDGLHLARQGDYDVVVLDIMLPRLSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             VC +LR +  W P+LML+A+    D   GLD GADDYLTKPF+   L ARLRAL RRG 
Sbjct  61   NVCKQLRAEENWVPILMLSAKDGEYDMADGLDLGADDYLTKPFSYVVLVARLRALLRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L AGDL LDP+  RV R +T + L+ +EF LLE L+RR   V ++ ++LE  WD
Sbjct  121  NRRPSVLRAGDLSLDPARRRVSRGETPVELTPREFALLEYLMRRHDEVVSKTEILEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGG  247
              ++   N+V+VY+ YLR KID PF  T+L+T+RGAGYRL  DGG
Sbjct  181  -TFDTDPNVVEVYVGYLRRKIDVPFSRTALQTVRGAGYRLAGDGG  224


>gi|283797521|ref|ZP_06346674.1| transcriptional activator protein Irlr [Clostridium sp. M62/1]
 gi|291074890|gb|EFE12254.1| transcriptional activator protein Irlr [Clostridium sp. M62/1]
Length=223

 Score =  218 bits (555),  Expect = 7e-55, Method: Compositional matrix adjust.
 Identities = 114/223 (52%), Positives = 142/223 (64%), Gaps = 0/223 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RIL  EDEP +  +  + L  EG  VD   DGR A+  +D  DYD V+LD+M+PGIDG 
Sbjct  1    MRILFAEDEPALREVTVKRLKAEGFGVDGCRDGREALDYLDSTDYDVVILDIMMPGIDGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             V   LR +    PV++LTAR AV DR+ GLD GADDYLTKPF   EL AR+RAL RR  
Sbjct  61   TVLRTLRSRGNTAPVMLLTARDAVADRVGGLDAGADDYLTKPFEFAELTARIRALLRRNS  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              +  T    DL ++ S  +V R   EI LS +EF LLE+LIR  G + +R QL  + WD
Sbjct  121  DNKTDTASVADLTVEFSTRKVTRGGVEISLSSREFALLESLIRHKGAILSRTQLENQVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
              +E  SNIVDVYIRYLR KID PF    + T+RGAGY LR++
Sbjct  181  FGFEGGSNIVDVYIRYLRKKIDDPFEKKLIHTVRGAGYTLREE  223


>gi|342858651|ref|ZP_08715306.1| TcrA protein [Mycobacterium colombiense CECT 3035]
 gi|342134355|gb|EGT87535.1| TcrA protein [Mycobacterium colombiense CECT 3035]
Length=222

 Score =  217 bits (553),  Expect = 1e-54, Method: Compositional matrix adjust.
 Identities = 109/220 (50%), Positives = 144/220 (66%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+VEDEP+++A + R L  EG  V  V +G   +       +D ++LD+MLPG+ G+
Sbjct  1    MRVLLVEDEPRLSATVVRGLKAEGFVVMAVGNGVDGLREATENGFDVIILDIMLPGLSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV  RLR   VWTPVLMLTA+    D     D GADDYLTKPF+   L ARLRAL RRG 
Sbjct  61   EVLRRLRSHNVWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALIRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L+AG L LDP+ H V R  T I L+ +E+ +LE L+R   +V T+A++L+  WD
Sbjct  121  PARPVVLKAGTLTLDPARHTVKRGSTPIALTPREYGVLEFLMRNKDVVVTKAEILQNVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
            A +    N+V+VY+ YLR KID PFG  ++ETIRG GYRL
Sbjct  181  AHFHGPDNVVEVYVGYLRRKIDVPFGTNTIETIRGVGYRL  220


>gi|304317403|ref|YP_003852548.1| transcriptional regulator [Thermoanaerobacterium thermosaccharolyticum 
DSM 571]
 gi|302778905|gb|ADL69464.1| two component transcriptional regulator, winged helix family 
[Thermoanaerobacterium thermosaccharolyticum DSM 571]
Length=225

 Score =  217 bits (553),  Expect = 1e-54, Method: Compositional matrix adjust.
 Identities = 105/222 (48%), Positives = 148/222 (67%), Gaps = 0/222 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVV+DEP +T LL +AL EEG++VD   +G   +       YD ++LD+MLP IDG 
Sbjct  1    MRILVVDDEPYLTDLLNKALKEEGYSVDIAQNGIDGMECAKMNVYDVIILDIMLPEIDGI  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            ++   LR   + TP+LMLTA+ A+ D++ GLD GADDY+TKPF L EL AR+RAL RR  
Sbjct  61   QILKNLRNMNINTPILMLTAKDALDDKVKGLDTGADDYMTKPFELSELTARIRALLRREQ  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              + P L+  DL ++   H V R    I L+ KE++LLE ++R  G V TR+Q+++  W 
Sbjct  121  PSKSPILKIADLEVNTLTHDVRRGGKIITLTSKEYSLLEYMMRNSGRVLTRSQIVDHVWG  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRK  244
              ++  SNI+DVYIRYLR KID  F +  ++TIRG+GY L++
Sbjct  181  YEFDGLSNIIDVYIRYLRKKIDDNFDIKLIQTIRGSGYCLKE  222


>gi|114778428|ref|ZP_01453273.1| response regulator receiver domain protein (CheY-like) [Mariprofundus 
ferrooxydans PV-1]
 gi|114551272|gb|EAU53830.1| response regulator receiver domain protein (CheY-like) [Mariprofundus 
ferrooxydans PV-1]
Length=227

 Score =  217 bits (552),  Expect = 1e-54, Method: Compositional matrix adjust.
 Identities = 110/223 (50%), Positives = 142/223 (64%), Gaps = 0/223 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            ++ILVVEDE ++   + + L EEGH VD   DG       +  DYD ++LD+MLP  +G 
Sbjct  1    MKILVVEDEERVAHFIQKGLKEEGHAVDISYDGEDGEFLAEVNDYDLIILDLMLPKKNGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             VC  LR   V TPVLMLTAR +V D++ GLD GADDYL KPF  +EL AR+RAL RR  
Sbjct  61   VVCRELRASGVSTPVLMLTARDSVEDKVRGLDAGADDYLAKPFAFEELLARVRALLRRKS  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              + P L+  DL LDP   RV R  + IRL+ KE+ LLE L+R PG V +R  + E  WD
Sbjct  121  ESKSPVLKVADLELDPISRRVSRQGSSIRLTTKEYALLEYLMRNPGKVLSRTLIGEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
              ++  SN++DVYI +LR KID+ F V+ L T+RG GY L  D
Sbjct  181  MNFDPESNVIDVYISHLRSKIDKGFDVSLLHTLRGQGYLLTDD  223


>gi|298249466|ref|ZP_06973270.1| two component transcriptional regulator, winged helix family 
[Ktedonobacter racemifer DSM 44963]
 gi|297547470|gb|EFH81337.1| two component transcriptional regulator, winged helix family 
[Ktedonobacter racemifer DSM 44963]
Length=233

 Score =  217 bits (552),  Expect = 1e-54, Method: Compositional matrix adjust.
 Identities = 117/222 (53%), Positives = 144/222 (65%), Gaps = 2/222 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            + ILVVEDE K+  LL R L EE HTV+   DG   +   + G YDAVVLDVMLP +DGF
Sbjct  1    MHILVVEDEKKLAHLLRRVLQEESHTVNLAYDGLSGLELAESGTYDAVVLDVMLPELDGF  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRR--  140
            E+C R+R   V +PVLMLTARG+V DR+AGL+ GADDYL KPF ++EL AR+ AL RR  
Sbjct  61   EICRRMRTDNVMSPVLMLTARGSVEDRVAGLNVGADDYLPKPFAMEELLARVNALLRRRD  120

Query  141  GPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERC  200
                    L A DL LD   H   R +  I L+ KEF LLE L+R PG   TR Q+ +  
Sbjct  121  RTFEVATQLRADDLILDLVRHEARRGERVIELTAKEFALLEYLMRHPGQALTRTQITDAV  180

Query  201  WDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
            W    EA SN+VD+YI YLRDKID+ F    ++T+RG GY+L
Sbjct  181  WRYDLEALSNVVDIYIHYLRDKIDQGFTRPLIKTVRGIGYKL  222


>gi|118464519|ref|YP_882587.1| TcrA protein [Mycobacterium avium 104]
 gi|118165806|gb|ABK66703.1| TcrA protein [Mycobacterium avium 104]
Length=222

 Score =  217 bits (552),  Expect = 1e-54, Method: Compositional matrix adjust.
 Identities = 112/220 (51%), Positives = 142/220 (65%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+VEDEP++ A +AR L  EG  V TV +G   +A      +D V+LD+MLPG  G+
Sbjct  1    MRVLLVEDEPRLAATVARGLKAEGFVVVTVGNGVDGLAEATENPFDVVILDIMLPGRSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV  R+R   VWTPVLMLTA+    D     D GADDYLTKPF+   L ARLRAL RRG 
Sbjct  61   EVLRRMRSNNVWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L AG L LDP+ H V R  T I L+ +E+ +LE L+R   +V T+A +L   WD
Sbjct  121  PERPVVLTAGSLSLDPARHTVQRGSTPIALTPREYGVLEFLMRNKDVVVTKADILANVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
            A +    N+V+VY+ YLR KID PFG  ++ETIRG GYRL
Sbjct  181  AHHHGPDNVVEVYVGYLRRKIDVPFGTNTIETIRGVGYRL  220


>gi|167745896|ref|ZP_02418023.1| hypothetical protein ANACAC_00590 [Anaerostipes caccae DSM 14662]
 gi|167654411|gb|EDR98540.1| hypothetical protein ANACAC_00590 [Anaerostipes caccae DSM 14662]
Length=224

 Score =  217 bits (552),  Expect = 2e-54, Method: Compositional matrix adjust.
 Identities = 106/223 (48%), Positives = 145/223 (66%), Gaps = 0/223 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+VEDE  + ++L + L +E +T D   +G  A+  ++  DYD ++LD+MLPGIDG 
Sbjct  1    MRLLIVEDEEDLRSILKKKLMKEHYTADDCGNGLDALDYINMADYDGIILDIMLPGIDGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            E+  ++R +   TPVL LTAR  + DR+ GLD GADDYL KPF+ +EL AR+R + RR P
Sbjct  61   ELLKKIREEGNDTPVLFLTARDGIEDRVKGLDLGADDYLVKPFSFEELMARVRVMMRRKP  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
                  L  GDL LD     V RAD +I LS KEF +LE ++R   IV +R Q+ +  W+
Sbjct  121  ALVSNRLTIGDLVLDCESKEVTRADKKISLSSKEFMVLEYMLRNQNIVLSREQIEQHAWN  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
              +E  SN+VDVYIRYLR KID  FG   + T+RG GY LRK+
Sbjct  181  YDFEGGSNVVDVYIRYLRKKIDEGFGCKLIHTVRGVGYVLRKE  223


>gi|295090875|emb|CBK76982.1| Response regulators consisting of a CheY-like receiver domain 
and a winged-helix DNA-binding domain [Clostridium cf. saccharolyticum 
K10]
Length=223

 Score =  216 bits (551),  Expect = 2e-54, Method: Compositional matrix adjust.
 Identities = 113/223 (51%), Positives = 141/223 (64%), Gaps = 0/223 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RIL  EDEP +  +  + L  EG  VD   DGR  +  +D  DYD V+LD+M+PGIDG 
Sbjct  1    MRILFAEDEPALREVTVKRLKAEGFGVDGCRDGREVLDYLDSTDYDVVILDIMMPGIDGL  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             V   LR +    PV++LTAR AV DR+ GLD GADDYLTKPF   EL AR+RAL RR  
Sbjct  61   TVLRTLRSRGNTVPVMLLTARDAVADRVGGLDAGADDYLTKPFEFAELTARIRALLRRNS  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              +  T    DL ++ S  +V R   EI LS +EF LLE+LIR  G + +R QL  + WD
Sbjct  121  DNKTDTASVADLTVEFSTRKVTRGGVEISLSSREFALLESLIRHKGAILSRTQLENQVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
              +E  SNIVDVYIRYLR KID PF    + T+RGAGY LR++
Sbjct  181  FGFEGGSNIVDVYIRYLRKKIDDPFEKKLIHTVRGAGYTLREE  223


>gi|254775852|ref|ZP_05217368.1| TcrA [Mycobacterium avium subsp. avium ATCC 25291]
Length=222

 Score =  216 bits (550),  Expect = 2e-54, Method: Compositional matrix adjust.
 Identities = 111/220 (51%), Positives = 142/220 (65%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +++L+VEDEP++ A +AR L  EG  V TV +G   +A      +D V+LD+MLPG  G+
Sbjct  1    MKVLLVEDEPRLAATVARGLKAEGFVVVTVGNGVDGLAEATENPFDVVILDIMLPGRSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV  R+R   VWTPVLMLTA+    D     D GADDYLTKPF+   L ARLRAL RRG 
Sbjct  61   EVLRRMRSNNVWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L AG L LDP+ H V R  T I L+ +E+ +LE L+R   +V T+A +L   WD
Sbjct  121  PERPVVLTAGSLSLDPARHTVQRGSTPIALTPREYGVLEFLMRNKDVVVTKADILANVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
            A +    N+V+VY+ YLR KID PFG  ++ETIRG GYRL
Sbjct  181  AHHHGPDNVVEVYVGYLRRKIDVPFGTNTIETIRGVGYRL  220


>gi|39995559|ref|NP_951510.1| DNA-binding response regulator [Geobacter sulfurreducens PCA]
 gi|39982322|gb|AAR33783.1| DNA-binding response regulator [Geobacter sulfurreducens PCA]
 gi|298504564|gb|ADI83287.1| winged-helix transcriptional response regulator [Geobacter sulfurreducens 
KN400]
Length=224

 Score =  216 bits (550),  Expect = 3e-54, Method: Compositional matrix adjust.
 Identities = 109/224 (49%), Positives = 146/224 (66%), Gaps = 2/224 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVA-AVDGGDYDAVVLDVMLPGIDG  81
            +++LVVEDE K+++ + R L EE + VD   +G   +  A+D G YD +VLDVMLP  DG
Sbjct  1    MKVLVVEDEKKVSSFIKRGLEEEKYEVDAAFNGEEGLKMALDKG-YDLIVLDVMLPKKDG  59

Query  82   FEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRG  141
              V   LR ++  TPVLMLTA+ +V D +AGLD G+DDYLTKPF   EL AR+RAL RR 
Sbjct  60   LSVVRELRERKNSTPVLMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRS  119

Query  142  PIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCW  201
               R   +   DLRLDP  H+VWR D EI L+ KE++LLE  +R P  V TR  + E  W
Sbjct  120  EQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEYFMRNPNQVLTRTMIAEHVW  179

Query  202  DAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
            D  +++ +NI+DVY+ YLR KIDR      + T+RG GY L+++
Sbjct  180  DYTFDSFTNIIDVYVNYLRKKIDRESDKKLIHTVRGVGYILKEE  223


>gi|41407200|ref|NP_960036.1| TcrA [Mycobacterium avium subsp. paratuberculosis K-10]
 gi|41395551|gb|AAS03419.1| TcrA [Mycobacterium avium subsp. paratuberculosis K-10]
 gi|336461546|gb|EGO40413.1| response regulator with CheY-like receiver domain-containing 
protein [Mycobacterium avium subsp. paratuberculosis S397]
Length=222

 Score =  216 bits (549),  Expect = 3e-54, Method: Compositional matrix adjust.
 Identities = 111/220 (51%), Positives = 142/220 (65%), Gaps = 0/220 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +++L+VEDEP++ A +AR L  EG  V TV +G   +A      +D V+LD+MLPG  G+
Sbjct  1    MKVLLVEDEPRLAATVARGLKAEGFVVVTVGNGVDGLAEATENPFDIVILDIMLPGRSGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
            EV  R+R   VWTPVLMLTA+    D     D GADDYLTKPF+   L ARLRAL RRG 
Sbjct  61   EVLRRMRSNNVWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALVRRGA  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  L AG L LDP+ H V R  T I L+ +E+ +LE L+R   +V T+A +L   WD
Sbjct  121  PERPVVLTAGSLSLDPARHTVQRGSTPIALTPREYGVLEFLMRNKDVVVTKADILANVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRL  242
            A +    N+V+VY+ YLR KID PFG  ++ETIRG GYRL
Sbjct  181  AHHHGPDNVVEVYVGYLRRKIDVPFGTNTIETIRGVGYRL  220


>gi|271961705|ref|YP_003335901.1| response regulator receiver protein [Streptosporangium roseum 
DSM 43021]
 gi|270504880|gb|ACZ83158.1| response regulator receiver protein [Streptosporangium roseum 
DSM 43021]
Length=222

 Score =  215 bits (548),  Expect = 4e-54, Method: Compositional matrix adjust.
 Identities = 113/222 (51%), Positives = 145/222 (66%), Gaps = 0/222 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +R+L+VEDE ++  LL   L  EG  VD   DGR  +       YD +VLDVMLP ++G+
Sbjct  1    MRVLLVEDEKRLADLLKGGLAGEGFAVDVAHDGRDGLWMASENVYDVIVLDVMLPRMNGY  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             VCARLR    WTP+LMLTA+  V D    LD GADD+L+KPF+   L ARLRAL RRG 
Sbjct  61   TVCARLRDAENWTPILMLTAKDGVHDEAEALDTGADDFLSKPFSYVVLLARLRALIRRGG  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP ++  GDL +DP+  R  R + EI L+ KEF +L  L RRPG V ++++LL + WD
Sbjct  121  RARPVSITVGDLTVDPAGLRCRRGEVEIALTPKEFAVLHGLARRPGEVVSKSELLAQAWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRK  244
             +Y+   NIV+VYI  LR KID PFG +SL T+RGAGYRL  
Sbjct  181  FSYDGDPNIVEVYISALRRKIDSPFGRSSLVTVRGAGYRLES  222


>gi|119715846|ref|YP_922811.1| two component transcriptional regulator [Nocardioides sp. JS614]
 gi|119536507|gb|ABL81124.1| two component transcriptional regulator, winged helix family 
[Nocardioides sp. JS614]
Length=232

 Score =  215 bits (548),  Expect = 4e-54, Method: Compositional matrix adjust.
 Identities = 111/223 (50%), Positives = 143/223 (65%), Gaps = 0/223 (0%)

Query  23   VRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGF  82
            +RILVVED+ ++ A L R L  EGH VD    G           YDA+V+DVMLPG+ G 
Sbjct  1    MRILVVEDDKQLAAALRRGLESEGHAVDVALTGTDGEWYASENTYDAMVVDVMLPGLTGD  60

Query  83   EVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGP  142
             +CAR R    WTP+LMLTAR         LD GADD+L+KPF+   L ARLRAL RR  
Sbjct  61   ALCARRRESGDWTPILMLTARSGPEQEARALDAGADDFLSKPFSFMVLTARLRALLRRDS  120

Query  143  IPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWD  202
              RP  LE GDLRLDP+ HRVWR DT I L+ K+F+LLE ++R    + +++ +LE  WD
Sbjct  121  RERPTVLEVGDLRLDPALHRVWRGDTSIDLTPKQFSLLEFMMRHADHILSKSMILEHVWD  180

Query  203  AAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKD  245
             +Y+   NIV+VY+R LR +ID PF  +SL+T+R  GYR+  D
Sbjct  181  FSYDGHPNIVEVYVRQLRQRIDEPFQRSSLQTVRLVGYRVVDD  223



Lambda     K      H
   0.323    0.141    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 368391130380




  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40