BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0753c Length=510 Score E Sequences producing significant alignments: (Bits) Value gi|15607893|ref|NP_215267.1| methylmalonate-semialdehyde dehydro... 1037 0.0 gi|254231067|ref|ZP_04924394.1| methylmalonate-semialdehyde dehy... 1036 0.0 gi|15840167|ref|NP_335204.1| methylmalonic acid semialdehyde deh... 1036 0.0 gi|31791940|ref|NP_854433.1| methylmalonate-semialdehyde dehydro... 1034 0.0 gi|41410313|ref|NP_963149.1| MmsA [Mycobacterium avium subsp. pa... 959 0.0 gi|118464277|ref|YP_883552.1| methylmalonate-semialdehyde dehydr... 957 0.0 gi|254776849|ref|ZP_05218365.1| MmsA [Mycobacterium avium subsp.... 955 0.0 gi|342861850|ref|ZP_08718495.1| methylmalonate-semialdehyde dehy... 951 0.0 gi|254819200|ref|ZP_05224201.1| MmsA [Mycobacterium intracellula... 946 0.0 gi|240167760|ref|ZP_04746419.1| MmsA [Mycobacterium kansasii ATC... 939 0.0 gi|183981099|ref|YP_001849390.1| methylmalonate semialdehyde deh... 938 0.0 gi|118616614|ref|YP_904946.1| methylmalonate semialdehyde dehydr... 937 0.0 gi|254819931|ref|ZP_05224932.1| methylmalonate-semialdehyde dehy... 933 0.0 gi|118462384|ref|YP_881713.1| methylmalonate-semialdehyde dehydr... 933 0.0 gi|296168604|ref|ZP_06850408.1| methylmalonic acid semialdehyde ... 931 0.0 gi|120402373|ref|YP_952202.1| methylmalonate-semialdehyde dehydr... 891 0.0 gi|145225586|ref|YP_001136264.1| methylmalonate-semialdehyde deh... 885 0.0 gi|333991931|ref|YP_004524545.1| methylmalonate semialdehyde deh... 878 0.0 gi|108798037|ref|YP_638234.1| methylmalonate-semialdehyde dehydr... 870 0.0 gi|118468130|ref|YP_885880.1| methylmalonate-semialdehyde dehydr... 865 0.0 gi|296140758|ref|YP_003648001.1| methylmalonate-semialdehyde deh... 845 0.0 gi|262203763|ref|YP_003274971.1| methylmalonate-semialdehyde deh... 815 0.0 gi|343926074|ref|ZP_08765586.1| methylmalonate-semialdehyde dehy... 811 0.0 gi|326381425|ref|ZP_08203119.1| methylmalonate-semialdehyde dehy... 760 0.0 gi|134098042|ref|YP_001103703.1| methylmalonate-semialdehyde deh... 749 0.0 gi|319950405|ref|ZP_08024321.1| methylmalonate-semialdehyde dehy... 749 0.0 gi|169628282|ref|YP_001701931.1| methylmalonic acid semialdehyde... 738 0.0 gi|325673564|ref|ZP_08153255.1| methylmalonate-semialdehyde dehy... 737 0.0 gi|312139133|ref|YP_004006469.1| methylmalonic acid semialdehyde... 736 0.0 gi|226360659|ref|YP_002778437.1| methylmalonate-semialdehyde deh... 736 0.0 gi|170740706|ref|YP_001769361.1| methylmalonate-semialdehyde deh... 733 0.0 gi|323137059|ref|ZP_08072139.1| methylmalonate-semialdehyde dehy... 728 0.0 gi|27379065|ref|NP_770594.1| methylmalonate-semialdehyde dehydro... 728 0.0 gi|115524390|ref|YP_781301.1| methylmalonate-semialdehyde dehydr... 728 0.0 gi|110635647|ref|YP_675855.1| methylmalonate-semialdehyde dehydr... 726 0.0 gi|90424586|ref|YP_532956.1| methylmalonate-semialdehyde dehydro... 726 0.0 gi|239832916|ref|ZP_04681245.1| methylmalonate-semialdehyde dehy... 723 0.0 gi|192292306|ref|YP_001992911.1| methylmalonate-semialdehyde deh... 723 0.0 gi|148254989|ref|YP_001239574.1| methylmalonate-semialdehyde deh... 723 0.0 gi|265984837|ref|ZP_06097572.1| methylmalonate-semialdehyde dehy... 722 0.0 gi|146340122|ref|YP_001205170.1| methylmalonate-semialdehyde deh... 722 0.0 gi|39936513|ref|NP_948789.1| methylmalonate-semialdehyde dehydro... 721 0.0 gi|316933287|ref|YP_004108269.1| methylmalonate-semialdehyde deh... 721 0.0 gi|23502685|ref|NP_698812.1| methylmalonic acid semialdehyde deh... 721 0.0 gi|161619751|ref|YP_001593638.1| methylmalonate-semialdehyde deh... 720 0.0 gi|148560620|ref|YP_001259669.1| methylmalonate-semialdehyde deh... 720 0.0 gi|261754231|ref|ZP_05997940.1| methylmalonate-semialdehyde dehy... 720 0.0 gi|153008402|ref|YP_001369617.1| methylmalonate-semialdehyde deh... 720 0.0 gi|289573371|ref|ZP_06453598.1| methylmalonate-semialdehyde dehy... 720 0.0 gi|328885619|emb|CCA58858.1| Methylmalonate-semialdehyde dehydro... 720 0.0 >gi|15607893|ref|NP_215267.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium tuberculosis H37Rv] gi|121636676|ref|YP_976899.1| putative methylmalonate-semialdehyde dehydrogenase mmsA [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|148660529|ref|YP_001282052.1| MmsA [Mycobacterium tuberculosis H37Ra] 71 more sequence titles Length=510 Score = 1037 bits (2682), Expect = 0.0, Method: Compositional matrix adjust. Identities = 510/510 (100%), Positives = 510/510 (100%), Gaps = 0/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA Sbjct 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR Sbjct 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE Sbjct 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA Sbjct 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS Sbjct 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 >gi|254231067|ref|ZP_04924394.1| methylmalonate-semialdehyde dehydrogenase mmsA [Mycobacterium tuberculosis C] gi|124600126|gb|EAY59136.1| methylmalonate-semialdehyde dehydrogenase mmsA [Mycobacterium tuberculosis C] Length=510 Score = 1036 bits (2678), Expect = 0.0, Method: Compositional matrix adjust. Identities = 509/510 (99%), Positives = 510/510 (100%), Gaps = 0/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA Sbjct 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR Sbjct 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGR+RASDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRERASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE Sbjct 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA Sbjct 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS Sbjct 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 >gi|15840167|ref|NP_335204.1| methylmalonic acid semialdehyde dehydrogenase [Mycobacterium tuberculosis CDC1551] gi|13880320|gb|AAK45018.1| methylmalonic acid semialdehyde dehydrogenase [Mycobacterium tuberculosis CDC1551] gi|323720783|gb|EGB29853.1| methylmalonate-semialdehyde dehydrogenase mmsA [Mycobacterium tuberculosis CDC1551A] Length=510 Score = 1036 bits (2678), Expect = 0.0, Method: Compositional matrix adjust. Identities = 509/510 (99%), Positives = 509/510 (99%), Gaps = 0/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 M TQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA Sbjct 1 MATQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR Sbjct 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE Sbjct 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA Sbjct 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS Sbjct 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 >gi|31791940|ref|NP_854433.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium bovis AF2122/97] gi|31617527|emb|CAD93637.1| PROBABLE METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE MMSA (METHYLMALONIC ACID SEMIALDEHYDE DEHYDROGENASE) (MMSDH) [Mycobacterium bovis AF2122/97] Length=510 Score = 1034 bits (2674), Expect = 0.0, Method: Compositional matrix adjust. Identities = 509/510 (99%), Positives = 509/510 (99%), Gaps = 0/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA Sbjct 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR Sbjct 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE Sbjct 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSR QVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA Sbjct 421 YGNGVAIFTRDGDAARDFVSRGQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS Sbjct 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 >gi|41410313|ref|NP_963149.1| MmsA [Mycobacterium avium subsp. paratuberculosis K-10] gi|41399147|gb|AAS06765.1| MmsA [Mycobacterium avium subsp. paratuberculosis K-10] gi|336460723|gb|EGO39613.1| methylmalonic acid semialdehyde dehydrogenase [Mycobacterium avium subsp. paratuberculosis S397] Length=506 Score = 959 bits (2478), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/509 (92%), Positives = 493/509 (97%), Gaps = 4/509 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDGQRTAGQSTR+ADVFDP+TG +QA+VPMAG++DIDAAVASA+EAQKGWAA Sbjct 1 MTTQIPHFIDGQRTAGQSTRTADVFDPSTGAVQAQVPMAGRADIDAAVASAIEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQRRARVLMRFIELVN DELAELLSREHGKTLADA+GD+QRGIEVIEFC+GIPHLL Sbjct 61 TNPQRRARVLMRFIELVNQHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GVFQVVHGDKEAVDAIL+HPDI+AVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGD+TA+RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDKTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARL+ERINNLRVGHSLDPKADYGPLVTGAA+ARVRDYI QGVAAGAE+VVDGR+R SDDL Sbjct 301 ARLVERINNLRVGHSLDPKADYGPLVTGAAVARVRDYIDQGVAAGAEIVVDGRERRSDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA++YEEALRLPSEHE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAQNYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVA+FTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+ Sbjct 417 YGNGVAVFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 505 >gi|118464277|ref|YP_883552.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium avium 104] gi|118165564|gb|ABK66461.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium avium 104] Length=506 Score = 957 bits (2474), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/509 (92%), Positives = 493/509 (97%), Gaps = 4/509 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDGQRTAGQSTR+A+VFDP+TG +QA+VPMAG++DIDAAVASA+EAQKGWAA Sbjct 1 MTTQIPHFIDGQRTAGQSTRTAEVFDPSTGAVQAQVPMAGRADIDAAVASAIEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQRRARVLMRFIELVN DELAELLSREHGKTLADA+GD+QRGIEVIEFC+GIPHLL Sbjct 61 TNPQRRARVLMRFIELVNQHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GVFQVVHGDKEAVDAIL+HPDI+AVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGD+TA+RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDKTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARL+ERINNLRVGHSLDPKADYGPLVTGAA+ARVRDYI QGVAAGAE+VVDGR+R SDDL Sbjct 301 ARLVERINNLRVGHSLDPKADYGPLVTGAAVARVRDYIDQGVAAGAEIVVDGRERRSDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA++YEEALRLPSEHE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAQNYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVA+FTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+ Sbjct 417 YGNGVAVFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 505 >gi|254776849|ref|ZP_05218365.1| MmsA [Mycobacterium avium subsp. avium ATCC 25291] Length=506 Score = 955 bits (2468), Expect = 0.0, Method: Compositional matrix adjust. Identities = 465/509 (92%), Positives = 492/509 (97%), Gaps = 4/509 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDGQRTAGQSTR+ADVFDP+TG +QA+VPMAG++DIDAAVASA+EAQKGWAA Sbjct 1 MTTQIPHFIDGQRTAGQSTRTADVFDPSTGAVQAQVPMAGRADIDAAVASAIEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQRRARVLMRFIELVN DELAELLSREHGKTLADA+GD+QRGIEVIEFC+GIPHLL Sbjct 61 TNPQRRARVLMRFIELVNQHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GVFQVVHGDKEAVDAIL+HPDI+AVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGD+TA+RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDKTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARL+ERINNLRVGHSLDPKADYGPLVTGAA+ARVRDYI QGVAAGAE+VVDGR+R SDDL Sbjct 301 ARLVERINNLRVGHSLDPKADYGPLVTGAAVARVRDYIDQGVAAGAEIVVDGRERRSDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA++YEEAL LPS+HE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAQNYEEALALPSQHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVA+FTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+ Sbjct 417 YGNGVAVFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 505 >gi|342861850|ref|ZP_08718495.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium colombiense CECT 3035] gi|342130667|gb|EGT83971.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium colombiense CECT 3035] Length=506 Score = 951 bits (2457), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/509 (92%), Positives = 486/509 (96%), Gaps = 4/509 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDGQRTAGQS RSADVFDP+TG +QA VPMAG++DIDAAVASAVEAQKGWAA Sbjct 1 MTTQIPHFIDGQRTAGQSARSADVFDPSTGAVQATVPMAGQADIDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQRRARV+MRFIELVN IDELAELLSREHGKTL DA+GD+QRGIEVIEFC+GIPHLL Sbjct 61 TNPQRRARVMMRFIELVNKHIDELAELLSREHGKTLPDAKGDIQRGIEVIEFCIGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GVFQVVHGDKEAVD IL+HPDI+AVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFVEAGLPPGVFQVVHGDKEAVDTILNHPDIQAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGD+TA+RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDKTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVT AA+ARVRDYI QGV AGAELV+DGR+R+SDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTEAAVARVRDYIAQGVDAGAELVIDGRERSSDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA DYEEALRLPSEHE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAHDYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP++ Sbjct 417 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPSS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 I FYTK KTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IIFYTKTKTVTSRWPSGIKDGAEFVIPTM 505 >gi|254819200|ref|ZP_05224201.1| MmsA [Mycobacterium intracellulare ATCC 13950] Length=506 Score = 946 bits (2445), Expect = 0.0, Method: Compositional matrix adjust. Identities = 463/509 (91%), Positives = 488/509 (96%), Gaps = 4/509 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDG+RTAGQS R+ADVFDP+TG +QA+VPMAG++DIDAAVASA+EAQKGWAA Sbjct 1 MTTQIPHFIDGRRTAGQSGRTADVFDPSTGSVQAQVPMAGQADIDAAVASALEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQRRARV+MRFIELVN DELAELLSREHGKTLADA+GD+QRGIEVIEF +GIPHLL Sbjct 61 TNPQRRARVMMRFIELVNKHNDELAELLSREHGKTLADAKGDIQRGIEVIEFAIGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GVFQVVHGDKEAVDAIL+HPDI+AVGFVGSS+IAQYIYAGAAA Sbjct 181 SVPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQAVGFVGSSEIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG+QTA+RLR Sbjct 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEQTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVT AA+ARVRDYIGQGV AGAELV+DGR+RASDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTEAAVARVRDYIGQGVDAGAELVIDGRERASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA DYEEALRLPSEHE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAHDYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP++ Sbjct 417 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPSS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 I FYTK KTVTSRWPSGIKDGAEFVIPTM Sbjct 477 ILFYTKTKTVTSRWPSGIKDGAEFVIPTM 505 >gi|240167760|ref|ZP_04746419.1| MmsA [Mycobacterium kansasii ATCC 12478] Length=506 Score = 939 bits (2428), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/510 (93%), Positives = 486/510 (96%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTT I HFIDGQRT GQSTR+ADVFDPNTGQ+QAKVPMAG++D+DAAVASAVEAQKGWAA Sbjct 1 MTTHIPHFIDGQRTTGQSTRTADVFDPNTGQVQAKVPMAGQADVDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVND DELAELLS EHGKTLADA GD+QRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNDHNDELAELLSLEHGKTLADAAGDIQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFLLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF EAGLP GVFQVVHGDKEAVDAIL+HPDIKAVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFAEAGLPPGVFQVVHGDKEAVDAILNHPDIKAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG+QTAERLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLIERINNLRVGHSLDPKADYGPLVT AAL RVRDYI QGV AGAE+V+DGR+RASDDL Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTEAALTRVRDYINQGVQAGAEIVIDGRERASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLCMVRA +YEEALRLPSEHE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPEMSIYTDEIFGPVLCMVRAHNYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGD ARDFVSRVQVGMVG+NVPIPVPVAYHTFGGWKRSGFGDLNQHGP + Sbjct 417 YGNGVAIFTRDGDTARDFVSRVQVGMVGINVPIPVPVAYHTFGGWKRSGFGDLNQHGPTS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMQ 506 >gi|183981099|ref|YP_001849390.1| methylmalonate semialdehyde dehydrogenase, MmsA [Mycobacterium marinum M] gi|183174425|gb|ACC39535.1| methylmalonate semialdehyde dehydrogenase, MmsA [Mycobacterium marinum M] Length=506 Score = 938 bits (2425), Expect = 0.0, Method: Compositional matrix adjust. Identities = 461/510 (91%), Positives = 483/510 (95%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDG+RT GQSTR+ADV DPNTGQ+QA VPMA ++DIDAAVA A EAQ GWAA Sbjct 1 MTTQIPHFIDGRRTPGQSTRTADVLDPNTGQVQATVPMAAQADIDAAVAGAAEAQIGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVN DELAELLSREHGKT+ DARGD+QRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVP+RLAELF+EAGLP GVFQVVHGDKEAVDAIL+HP+IKAVGFVGSSDIAQYIY+GAAA Sbjct 181 SVPLRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPEIKAVGFVGSSDIAQYIYSGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG+QTA+RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEQTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 A+L+ERINNLRVGHSLDPKADYGPLVT AAL RVRDYIGQGVA+GAELVVDGR+RASDDL Sbjct 301 AKLVERINNLRVGHSLDPKADYGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F GDANLEGG+FIGPTLFDHV MSIYTDEIFGPVLCMVRA DYEEALRLPSEHE Sbjct 361 AF----GDANLEGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVA+FTRDGD ARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP + Sbjct 417 YGNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPTS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMK 506 >gi|118616614|ref|YP_904946.1| methylmalonate semialdehyde dehydrogenase, MmsA [Mycobacterium ulcerans Agy99] gi|118568724|gb|ABL03475.1| methylmalonate semialdehyde dehydrogenase, MmsA [Mycobacterium ulcerans Agy99] Length=506 Score = 937 bits (2423), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/510 (91%), Positives = 482/510 (95%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDG+RT GQSTR+ADV DPNTGQ+QA VPMA ++DIDAAVA A EAQ GWAA Sbjct 1 MTTQIPHFIDGRRTPGQSTRTADVLDPNTGQVQATVPMAAQADIDAAVAGAAEAQVGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVN DELAELLSREHGKT+ DARGD+QRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNQNTDELAELLSREHGKTVPDARGDIQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVP+RLAELF+EAGLP GVFQVVHGDKEAVDAIL+HP+IKAVGFVGSSDIAQYIY+GAAA Sbjct 181 SVPLRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPEIKAVGFVGSSDIAQYIYSGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGS GERCMAISVAVPVG+QTA+RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSTGERCMAISVAVPVGEQTADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 A+L+ERINNLRVGHSLDPKADYGPLVT AAL RVRDYIGQGVA+GAELVVDGR+RASDDL Sbjct 301 AKLVERINNLRVGHSLDPKADYGPLVTEAALTRVRDYIGQGVASGAELVVDGRERASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F GDANLEGG+FIGPTLFDHV MSIYTDEIFGPVLCMVRA DYEEALRLPSEHE Sbjct 361 AF----GDANLEGGYFIGPTLFDHVTTDMSIYTDEIFGPVLCMVRAHDYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVA+FTRDGD ARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP + Sbjct 417 YGNGVAVFTRDGDTARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPTS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMK 506 >gi|254819931|ref|ZP_05224932.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium intracellulare ATCC 13950] Length=509 Score = 933 bits (2412), Expect = 0.0, Method: Compositional matrix adjust. Identities = 456/509 (90%), Positives = 480/509 (95%), Gaps = 4/509 (0%) Query 2 TTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAW 61 TT I HFIDGQRT GQS RSADVFDP+ G +QA VPMAG++DIDAAV SAVEAQKGWAA Sbjct 5 TTLIPHFIDGQRTTGQSGRSADVFDPSAGGVQATVPMAGQADIDAAVVSAVEAQKGWAAT 64 Query 62 NPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLK 121 NPQRRARV+MRFIELVN DELAELLSREHGKTLADA+GD+QRGIEVIEFC+GIPHLLK Sbjct 65 NPQRRARVMMRFIELVNKHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCIGIPHLLK 124 Query 122 GEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS 181 GEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS Sbjct 125 GEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS 184 Query 182 VPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAAT 241 VPVRLAELF+EAGLP GVFQVVHGDKEAVDAIL+HPDI+AVGFVGSS+IAQYIYAGAAAT Sbjct 185 VPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQAVGFVGSSEIAQYIYAGAAAT 244 Query 242 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRA 301 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTA+RLRA Sbjct 245 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTADRLRA 304 Query 302 RLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLT 361 RLIER+NNLRVGHSLDPKADYGPLVT AA+ARVRDYI QGV AGAELV+DGR+RASDDL Sbjct 305 RLIERVNNLRVGHSLDPKADYGPLVTEAAVARVRDYIAQGVDAGAELVIDGRERASDDLA 364 Query 362 FGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEY 421 F GDANLE GFFIGPTLFDHV MSIYTDEIFGPVLC+VRA DYEEALRLPSEHEY Sbjct 365 F----GDANLERGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAHDYEEALRLPSEHEY 420 Query 422 GNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAI 481 GNGVA+FTRDGDAARDFV+RVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP++I Sbjct 421 GNGVAVFTRDGDAARDFVARVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPSSI 480 Query 482 QFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 FYTK KTVTSRWPSGIKDGAEF IPTM+ Sbjct 481 TFYTKTKTVTSRWPSGIKDGAEFSIPTMN 509 >gi|118462384|ref|YP_881713.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium avium 104] gi|118163671|gb|ABK64568.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium avium 104] Length=509 Score = 933 bits (2411), Expect = 0.0, Method: Compositional matrix adjust. Identities = 457/508 (90%), Positives = 481/508 (95%), Gaps = 4/508 (0%) Query 2 TTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAW 61 TT I HFIDG+R+AGQS RSADVFDP+TG +QA VPMAG++DIDAAVASAVEAQKGWAA Sbjct 5 TTLIPHFIDGRRSAGQSGRSADVFDPSTGGVQATVPMAGQADIDAAVASAVEAQKGWAAT 64 Query 62 NPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLK 121 NPQRRARV+MRF+ELVN+ DELAELLSREHGKTLADA+GD+QRGIEVIEFC+GIPHLLK Sbjct 65 NPQRRARVMMRFVELVNEHNDELAELLSREHGKTLADAKGDIQRGIEVIEFCVGIPHLLK 124 Query 122 GEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS 181 GEY+EGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS Sbjct 125 GEYSEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS 184 Query 182 VPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAAT 241 VPVRLAELF+EAGLP GVFQVVHGDKEAVDAIL+HPDI+AVGFVGSSDIAQYIYAGAAAT Sbjct 185 VPVRLAELFVEAGLPPGVFQVVHGDKEAVDAILNHPDIQAVGFVGSSDIAQYIYAGAAAT 244 Query 242 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRA 301 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTA+RLRA Sbjct 245 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTADRLRA 304 Query 302 RLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLT 361 RLIER+NNLRVGHSLDPKADYGPLVT AALARVRDYI QGV AGAELV+DGR+RASDDL Sbjct 305 RLIERVNNLRVGHSLDPKADYGPLVTEAALARVRDYIAQGVDAGAELVIDGRERASDDLA 364 Query 362 FGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEY 421 F GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA DYEEAL LPS+HEY Sbjct 365 F----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAHDYEEALALPSQHEY 420 Query 422 GNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAI 481 GNGVA+FT DGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+I Sbjct 421 GNGVAVFTGDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPASI 480 Query 482 QFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 FYTK KTVT RWPSGIKDGAEF IPTM Sbjct 481 TFYTKTKTVTQRWPSGIKDGAEFSIPTM 508 >gi|296168604|ref|ZP_06850408.1| methylmalonic acid semialdehyde dehydrogenase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295896667|gb|EFG76306.1| methylmalonic acid semialdehyde dehydrogenase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=506 Score = 931 bits (2406), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/509 (91%), Positives = 486/509 (96%), Gaps = 4/509 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFIDGQRTAG+STR+ADVF+P+TG++Q++VPMAGK+DIDAAVASA EAQKGWAA Sbjct 1 MTTQIPHFIDGQRTAGRSTRTADVFNPSTGEVQSRVPMAGKADIDAAVASAAEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARV+MRFIELVN+ +DELAELLS EHGKT+AD+RGDVQRGIEVIEF +GIPHLL Sbjct 61 WNPQRRARVMMRFIELVNEHMDELAELLSLEHGKTVADSRGDVQRGIEVIEFAIGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GVFQVVHGDKEAVD ILHHPDI+AVGFVGSSDIAQYIYA AAA Sbjct 181 SVPVRLAELFVEAGLPPGVFQVVHGDKEAVDTILHHPDIQAVGFVGSSDIAQYIYATAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKR+QCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG+QTA RLR Sbjct 241 TGKRSQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEQTANRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARLI+RINNLRVGHSLDPKADYGPLVT AALARVR+YIGQGV AGAELV+DGR+RASDDL Sbjct 301 ARLIDRINNLRVGHSLDPKADYGPLVTEAALARVRNYIGQGVEAGAELVIDGRERASDDL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF GDANLEGGFFIGPTLFDHV MSIYTDEIFGPVLC+VRA DYEEAL LPSEHE Sbjct 361 TF----GDANLEGGFFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRAHDYEEALSLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPV+YHTFGGWKRSGFGDLNQHGP + Sbjct 417 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVSYHTFGGWKRSGFGDLNQHGPHS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 I FYTK KTVTSRWPSGIKDGAEFVIPTM Sbjct 477 ILFYTKTKTVTSRWPSGIKDGAEFVIPTM 505 >gi|120402373|ref|YP_952202.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium vanbaalenii PYR-1] gi|119955191|gb|ABM12196.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium vanbaalenii PYR-1] Length=534 Score = 891 bits (2303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 429/510 (85%), Positives = 469/510 (92%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTT+I HFIDG+R+ STR+ADV +P+TG +QA+V +A +D+D AVASAVEAQK WAA Sbjct 29 MTTRIPHFIDGKRSDLSSTRTADVLNPSTGAVQAEVLLASAADVDTAVASAVEAQKEWAA 88 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARV+M+FIELVN IDELAELLS EHGKT+ DA+GD+QRGIEVIEF +GIPHLL Sbjct 89 WNPQRRARVMMKFIELVNANIDELAELLSIEHGKTVPDAKGDIQRGIEVIEFAIGIPHLL 148 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGE+TEGAG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDP Sbjct 149 KGEFTEGAGSGIDVYSIRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDP 208 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLPAGVFQVVHGDKEAVDAIL HPDI+AVGFVGSSDIAQYIY+ AAA Sbjct 209 SVPVRLAELFLEAGLPAGVFQVVHGDKEAVDAILTHPDIQAVGFVGSSDIAQYIYSTAAA 268 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKR+QCFGGAKNHMI+MPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG++TA RLR Sbjct 269 NGKRSQCFGGAKNHMIIMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEETANRLR 328 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 RL+ER+N LRVGHSLDPKADYGPLVTGAAL RVRDYIGQGV AGAELVVDGR+R +D+L Sbjct 329 NRLVERVNQLRVGHSLDPKADYGPLVTGAALERVRDYIGQGVDAGAELVVDGRERTTDEL 388 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 +F D +L GFFIGPTLFDHV MSIYT EIFGPVLC+VRA+DY+EAL LPS+HE Sbjct 389 SF----DDQDLSKGFFIGPTLFDHVTTDMSIYTGEIFGPVLCIVRAKDYDEALSLPSKHE 444 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVS+VQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+ Sbjct 445 YGNGVAIFTRDGDAARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAS 504 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVT RWPSGIKDGAEFVIPTM Sbjct 505 IQFYTKVKTVTERWPSGIKDGAEFVIPTMK 534 >gi|145225586|ref|YP_001136264.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium gilvum PYR-GCK] gi|315445939|ref|YP_004078818.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium sp. Spyr1] gi|145218072|gb|ABP47476.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium gilvum PYR-GCK] gi|315264242|gb|ADU00984.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium sp. Spyr1] Length=506 Score = 885 bits (2287), Expect = 0.0, Method: Compositional matrix adjust. Identities = 423/510 (83%), Positives = 469/510 (92%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTT+I HFIDG+R+ STR+A V +P+TG++Q++V +A +D+D AVASAVEAQK WAA Sbjct 1 MTTRIPHFIDGKRSELASTRTAGVLNPSTGEVQSEVLLASAADVDTAVASAVEAQKEWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARV M+FI+LVND +DELAELLS EHGKT+AD++GD+QRGIEVIEF +GIPHLL Sbjct 61 WNPQRRARVFMKFIQLVNDHVDELAELLSIEHGKTVADSKGDIQRGIEVIEFAIGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGE+TE AG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDP Sbjct 121 KGEFTENAGTGIDVYSIRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVP+RLAELF+EAGLPAGVFQVV GDKEAVDAIL HPDI+AVGFVGSSDIAQYIY+ AAA Sbjct 181 SVPLRLAELFLEAGLPAGVFQVVQGDKEAVDAILTHPDIQAVGFVGSSDIAQYIYSTAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKR+QCFGGAKNHMI+MPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG++TA RLR Sbjct 241 HGKRSQCFGGAKNHMIIMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEETANRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 RL+ER+N LRVGHSLDPKADYGPLVTGAAL RVRDYIGQGV AGAELVVDGR+RA+D+L Sbjct 301 NRLVERVNQLRVGHSLDPKADYGPLVTGAALERVRDYIGQGVEAGAELVVDGRERATDEL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 +F D +L G+FIGPTLFDHV MSIYTDEIFGPVLC+VRA DY+EAL LP++HE Sbjct 361 SF----DDQDLSKGYFIGPTLFDHVTTDMSIYTDEIFGPVLCIVRAADYDEALSLPTKHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVS+VQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+ Sbjct 417 YGNGVAIFTRDGDAARDFVSKVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTKVKTVT RWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKVKTVTERWPSGIKDGAEFVIPTMK 506 >gi|333991931|ref|YP_004524545.1| methylmalonate semialdehyde dehydrogenase MmsA [Mycobacterium sp. JDM601] gi|333487899|gb|AEF37291.1| methylmalonate semialdehyde dehydrogenase MmsA [Mycobacterium sp. JDM601] Length=506 Score = 878 bits (2269), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/510 (86%), Positives = 465/510 (92%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 M+TQI HFIDG+RTAG S RS DVFDPNTG++QA +P+A +D+D AVASA AQ+GWAA Sbjct 1 MSTQIPHFIDGRRTAGGSQRSTDVFDPNTGEVQATLPLANTADVDGAVASAAAAQRGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQRRARV+MRFI+LVN DELAELLSREHGKTL DARGD+QRGIEVIEFC+GIPHLL Sbjct 61 QNPQRRARVMMRFIDLVNANADELAELLSREHGKTLDDARGDIQRGIEVIEFCVGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGE+TEGAGPGIDV+SLRQPLGVVAGITPFNFPAMIPLW+AGPALACGNAF+LKPSERDP Sbjct 121 KGEHTEGAGPGIDVFSLRQPLGVVAGITPFNFPAMIPLWQAGPALACGNAFILKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELF+EAGLP GV QVVHGDKEAVDA+LHH D+ A+GFVGSSDIAQYIY+ A A Sbjct 181 SVPVRLAELFVEAGLPPGVLQVVHGDKEAVDALLHHRDVAAIGFVGSSDIAQYIYSTATA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG+QTAERLR Sbjct 241 NGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 RL+ERINNLRVGHSLDPKADYGPLVT AAL RV DYIGQGVAAGAELV+DGR+RASDD Sbjct 301 GRLVERINNLRVGHSLDPKADYGPLVTRAALERVNDYIGQGVAAGAELVIDGRERASDDT 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F GDA+L GGFF GPTLFDHV MSIYTDEIFGPVLCMVRA DYEEALRLPSEHE Sbjct 361 QF----GDADLSGGFFAGPTLFDHVTTEMSIYTDEIFGPVLCMVRAADYEEALRLPSEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGD ARDF SRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHG A+ Sbjct 417 YGNGVAIFTRDGDTARDFTSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGTAS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 I FYTKVKTVT RWPSGIKDGAEF IPTM Sbjct 477 ITFYTKVKTVTQRWPSGIKDGAEFHIPTMQ 506 >gi|108798037|ref|YP_638234.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium sp. MCS] gi|119867132|ref|YP_937084.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium sp. KMS] gi|126433698|ref|YP_001069389.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium sp. JLS] gi|108768456|gb|ABG07178.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium sp. MCS] gi|119693221|gb|ABL90294.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium sp. KMS] gi|126233498|gb|ABN96898.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Mycobacterium sp. JLS] Length=506 Score = 870 bits (2249), Expect = 0.0, Method: Compositional matrix adjust. Identities = 428/510 (84%), Positives = 467/510 (92%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MT QI HFI+G+RTAG+STR+ADV +P+TG +QA+V + ++D+DAAVA A EAQK WAA Sbjct 1 MTNQIQHFINGKRTAGESTRTADVMNPSTGAVQAQVLLGSRADVDAAVAGAAEAQKEWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARV+MRFIELVN +DELAELLS EHGKT+ DA+GD+QRGIEVIEF +GIPHL+ Sbjct 61 WNPQRRARVMMRFIELVNQHMDELAELLSIEHGKTVPDAKGDIQRGIEVIEFAIGIPHLI 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDP Sbjct 121 KGEYTEGAGTGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAIL HP I+AVGFVGSSDIAQYIYAGA A Sbjct 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILEHPVIQAVGFVGSSDIAQYIYAGATA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG +TA+RLR Sbjct 241 NGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGKETADRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 RL+ER+NNLRVGHSLDPKADYGPLVT AAL RVRDYI QGV AGAE VVDGR+R+SD++ Sbjct 301 NRLVERVNNLRVGHSLDPKADYGPLVTEAALNRVRDYINQGVEAGAEAVVDGRERSSDEM 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F GD +LEGG+FIGPTLFDHV MSIYTDEIFGPVLC+VRA +YEEALRLP+EHE Sbjct 361 QF----GDDSLEGGYFIGPTLFDHVTPDMSIYTDEIFGPVLCIVRADNYEEALRLPTEHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGD ARDFV++VQVGMVGVNVPIPVPV+YHTFGGWKRSGFGDLNQHGP + Sbjct 417 YGNGVAIFTRDGDTARDFVAKVQVGMVGVNVPIPVPVSYHTFGGWKRSGFGDLNQHGPHS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 I FYTK KTVT RWPSGIKDGAEFVIPTM Sbjct 477 ILFYTKTKTVTQRWPSGIKDGAEFVIPTMK 506 >gi|118468130|ref|YP_885880.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155] gi|118169417|gb|ABK70313.1| methylmalonate-semialdehyde dehydrogenase [Mycobacterium smegmatis str. MC2 155] Length=506 Score = 865 bits (2236), Expect = 0.0, Method: Compositional matrix adjust. Identities = 424/510 (84%), Positives = 464/510 (91%), Gaps = 4/510 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQI HFI+G+RT+ STR+ADV +P+TG++QA+V +A +D+DAAV A EAQK WAA Sbjct 1 MTTQIQHFINGRRTSAGSTRTADVMNPSTGEVQAQVLLASAADVDAAVTGAAEAQKEWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 +NPQRRARVLM+FI+LVN DELA LLS EHGKT+AD+ GD+QRGIEVIEF +GIPHLL Sbjct 61 YNPQRRARVLMKFIDLVNQNADELARLLSIEHGKTVADSLGDIQRGIEVIEFAVGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGE+TEGAG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDP Sbjct 121 KGEFTEGAGTGIDVYSIRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLP GVFQVV GDKEAVDAIL HP ++AVGFVGSSDIAQYIY+ AAA Sbjct 181 SVPVRLAELFIEAGLPPGVFQVVQGDKEAVDAILTHPTVQAVGFVGSSDIAQYIYSTAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKR+QCFGGAKNHMI+MPDADLDQAVDALIGAGYGSAGERCMAISVAVPVG++TA RLR Sbjct 241 HGKRSQCFGGAKNHMIIMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEETANRLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 ARL ER+ LRVGHSLDPKADYGPLVT AAL RV+DYIGQGV AGAELVVDGR+RA+D+L Sbjct 301 ARLTERVKQLRVGHSLDPKADYGPLVTEAALNRVKDYIGQGVEAGAELVVDGRERATDEL 360 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 TF D +LEGG+FIGPTLFDHV MSIYTDEIFGPVLC+VRA DYEEAL LP++HE Sbjct 361 TF----DDQSLEGGYFIGPTLFDHVKTDMSIYTDEIFGPVLCIVRAHDYEEALSLPTKHE 416 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPA+ Sbjct 417 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAS 476 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 IQFYTK KTVT RWPSGIKDGAEFVIPTM Sbjct 477 IQFYTKTKTVTERWPSGIKDGAEFVIPTMK 506 >gi|296140758|ref|YP_003648001.1| methylmalonate-semialdehyde dehydrogenase [Tsukamurella paurometabola DSM 20162] gi|296028892|gb|ADG79662.1| methylmalonate-semialdehyde dehydrogenase [Tsukamurella paurometabola DSM 20162] Length=506 Score = 845 bits (2183), Expect = 0.0, Method: Compositional matrix adjust. Identities = 411/508 (81%), Positives = 453/508 (90%), Gaps = 5/508 (0%) Query 2 TTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAW 61 T I HFIDG+R G + R+A+VFDP+TG +QA VP+A +++D VA A EAQK WAA+ Sbjct 3 TRAIPHFIDGRRVEG-TGRTAEVFDPSTGAVQATVPLATTAEVDDVVARAKEAQKVWAAY 61 Query 62 NPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLK 121 NPQRRARV M+FIELV+ +DELA LLS EHGKTLADA GD+QRGIEVIEF +GIPHLLK Sbjct 62 NPQRRARVFMKFIELVHQNMDELASLLSSEHGKTLADAAGDIQRGIEVIEFSIGIPHLLK 121 Query 122 GEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS 181 GEYTEGAG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS Sbjct 122 GEYTEGAGTGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPS 181 Query 182 VPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAAT 241 VPVRLAELFIEAGLP GVFQVVHGDKE+VDA+L++PDIKAVGFVGSSDIAQYIY AA Sbjct 182 VPVRLAELFIEAGLPEGVFQVVHGDKESVDALLNNPDIKAVGFVGSSDIAQYIYETAAKN 241 Query 242 GKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRA 301 GKR+Q FGGAKNHMIV+PDADLDQAVDALIGAGYGSAGERCMAISVAVPVG++TA RLR Sbjct 242 GKRSQAFGGAKNHMIVLPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGEETANRLRE 301 Query 302 RLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLT 361 RL+ER+ LRVGHS DPKADYGPL+T AA+ R R YI QGV AGA+LVVDGR+RASD+LT Sbjct 302 RLVERVQQLRVGHSHDPKADYGPLITPAAVERTRSYIQQGVDAGADLVVDGRERASDELT 361 Query 362 FGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEY 421 F GDA+L GG ++GPTLFDHV MSIYTDEIFGPVLC+VRA+DYEEA+ LP+EHEY Sbjct 362 F----GDADLSGGNYLGPTLFDHVTKDMSIYTDEIFGPVLCIVRAKDYEEAIALPTEHEY 417 Query 422 GNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAI 481 GNGVAIFTRDGDAARDFV+RV+VGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP +I Sbjct 418 GNGVAIFTRDGDAARDFVARVEVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPHSI 477 Query 482 QFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 FYTK KTVTSRWPSGIKDGAEF IPTM Sbjct 478 LFYTKTKTVTSRWPSGIKDGAEFSIPTM 505 >gi|262203763|ref|YP_003274971.1| methylmalonate-semialdehyde dehydrogenase [Gordonia bronchialis DSM 43247] gi|262087110|gb|ACY23078.1| methylmalonate-semialdehyde dehydrogenase [Gordonia bronchialis DSM 43247] Length=513 Score = 815 bits (2105), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/512 (78%), Positives = 446/512 (88%), Gaps = 8/512 (1%) Query 2 TTQISHFIDGQRTAGQST----RSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKG 57 +T I H++DG+R + R ADVF+P+TG + A+VP+A + AAV +A AQ+ Sbjct 5 STTIPHYLDGKRVSADQLPGEHRYADVFNPSTGAVAAQVPLASTDQVAAAVETAKAAQRE 64 Query 58 WAAWNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIP 117 WAAWNPQRRARV+MRF++LVN DELA LS EHGKT ADARGD+QRG+EVIEF +GIP Sbjct 65 WAAWNPQRRARVMMRFVDLVNKNADELATQLSLEHGKTHADARGDIQRGLEVIEFAIGIP 124 Query 118 HLLKGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSE 177 HL+KGE+TEGAG GIDV+S+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSE Sbjct 125 HLIKGEFTEGAGSGIDVHSVRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSE 184 Query 178 RDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAG 237 RDPSVPVRLAELF EAGLP GVFQVVHGDKEAVDA+L HPD+KA+GFVGSSDIAQYIY Sbjct 185 RDPSVPVRLAELFTEAGLPDGVFQVVHGDKEAVDALLTHPDVKALGFVGSSDIAQYIYET 244 Query 238 AAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAE 297 AAA GKR+QCFGGAKNHMI+MPDA+LDQAVDALIGAGYGSAGERCMAISVAVPVG+QTAE Sbjct 245 AAAHGKRSQCFGGAKNHMIIMPDANLDQAVDALIGAGYGSAGERCMAISVAVPVGEQTAE 304 Query 298 RLRARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRAS 357 RLRA+L++++N LRVGHSLDPKADYGPLVT AAL RVR YI +G GAELV+DGR+R S Sbjct 305 RLRAKLVDKVNALRVGHSLDPKADYGPLVTAAALERVRGYIAKGAEEGAELVIDGRERTS 364 Query 358 DDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPS 417 D+ TF GD ++ GFFIGPTLFDHV M+ YTDEIFGPVL +VRA DYEEAL L S Sbjct 365 DEQTF----GDEDISNGFFIGPTLFDHVTKGMTSYTDEIFGPVLQIVRAHDYEEALALAS 420 Query 418 EHEYGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHG 477 +H+YGNGVAIFT+DGDAARDF SRV VGMVGVNVPIPVPVAY+TFGGWKRSGFGDLNQHG Sbjct 421 DHQYGNGVAIFTQDGDAARDFTSRVDVGMVGVNVPIPVPVAYYTFGGWKRSGFGDLNQHG 480 Query 478 PAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 PA+IQFYTK KT+TSRWPSGIKDGAEFVIPTM Sbjct 481 PASIQFYTKTKTITSRWPSGIKDGAEFVIPTM 512 >gi|343926074|ref|ZP_08765586.1| methylmalonate-semialdehyde dehydrogenase [Gordonia alkanivorans NBRC 16433] gi|343764000|dbj|GAA12512.1| methylmalonate-semialdehyde dehydrogenase [Gordonia alkanivorans NBRC 16433] Length=510 Score = 811 bits (2094), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/506 (79%), Positives = 448/506 (89%), Gaps = 4/506 (0%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HF++G+R + R ADVF+P+TG +QA+VP+A ++ AA+A+A EAQK WAAWNP Sbjct 8 SIPHFLNGKRVTAEGGRFADVFNPSTGAVQAQVPLASTDEVAAAIATASEAQKEWAAWNP 67 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARVLMRF++LVN DELA LS EHGKT ADA GD+QRGIEVIEF +GIPHL+KGE Sbjct 68 QRRARVLMRFVDLVNKNADELATTLSLEHGKTHADALGDIQRGIEVIEFAIGIPHLIKGE 127 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +TEGAG GIDV+S+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDPSVP Sbjct 128 FTEGAGGGIDVHSIRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDPSVP 187 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 VRLAELF EAGLP GVFQVVHGDKEAVDA+L HPD+KA+GFVGSSDIAQYIY+ AAA GK Sbjct 188 VRLAELFTEAGLPDGVFQVVHGDKEAVDALLTHPDVKALGFVGSSDIAQYIYSTAAAHGK 247 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R+QCFGGAKNH I+MPDA+LDQ VDALIGAGYGSAGERCMAISVAVPVG++TA+RLRA+L Sbjct 248 RSQCFGGAKNHAIIMPDANLDQVVDALIGAGYGSAGERCMAISVAVPVGEETADRLRAKL 307 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I+R+N LRVGHSLDPKADYGPLVT AAL RVR YI +GV GAE+V+DGR+R S++ TF Sbjct 308 IDRVNALRVGHSLDPKADYGPLVTAAALERVRGYITKGVDEGAEIVIDGRERTSNEQTF- 366 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 GD ++ GFFIGPTLFD V MSIYTDEIFGPVL +VRA DYEEAL L S+H+YGN Sbjct 367 ---GDDDISKGFFIGPTLFDRVTKDMSIYTDEIFGPVLTIVRAGDYEEALALASDHQYGN 423 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFT+DGDAARDF +RV+VGMVGVNVPIPVPVAY+TFGGWKRSGFGDLNQHGPA+IQF Sbjct 424 GVAIFTQDGDAARDFTARVEVGMVGVNVPIPVPVAYYTFGGWKRSGFGDLNQHGPASIQF 483 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTM 509 YTK KTVT+RWPSGIKDGAEFVIPTM Sbjct 484 YTKTKTVTTRWPSGIKDGAEFVIPTM 509 >gi|326381425|ref|ZP_08203119.1| methylmalonate-semialdehyde dehydrogenase [Gordonia neofelifaecis NRRL B-59395] gi|326199672|gb|EGD56852.1| methylmalonate-semialdehyde dehydrogenase [Gordonia neofelifaecis NRRL B-59395] Length=504 Score = 760 bits (1962), Expect = 0.0, Method: Compositional matrix adjust. Identities = 388/505 (77%), Positives = 439/505 (87%), Gaps = 5/505 (0%) Query 5 ISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQ 64 I H+++G A +ADV+DP+TG +QA VP+A +++D AVA A AQ WA +NPQ Sbjct 4 IDHYLNGAHVAATGA-TADVYDPSTGTVQATVPLATAAEVDDAVAIAKRAQPTWAGYNPQ 62 Query 65 RRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEY 124 RRARVLM+F++LVN +DELAELLS EHGKTLADARGDVQRG+EVIEF +GIPHLLKGEY Sbjct 63 RRARVLMKFVDLVNQNMDELAELLSSEHGKTLADARGDVQRGLEVIEFAIGIPHLLKGEY 122 Query 125 TEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPV 184 +EGAG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAF+LKPSERDPSVPV Sbjct 123 SEGAGAGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFILKPSERDPSVPV 182 Query 185 RLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKR 244 RLAELF EAGLP GVFQVVHGDK AVDA+L +PD+KAVGFVGSSDIAQYIY AAA GKR Sbjct 183 RLAELFTEAGLPDGVFQVVHGDKTAVDALLANPDVKAVGFVGSSDIAQYIYETAAANGKR 242 Query 245 AQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARLI 304 +QCFGGAKNHMI+ PDADLDQA DAL+GAGYG+AGERCMAISVAVP+GD TA+ LRA+L+ Sbjct 243 SQCFGGAKNHMIIAPDADLDQAADALVGAGYGAAGERCMAISVAVPIGDATADALRAKLV 302 Query 305 ERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGL 364 ERI LRVGHS DPKADYGPL+T AA RV DYI QGV+AGAE+VVDGR + + D TF Sbjct 303 ERIEALRVGHSHDPKADYGPLITSAARDRVLDYIEQGVSAGAEIVVDGRGKGATDETF-- 360 Query 365 PEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNG 424 DA+L GG+++GPTLFDHV MSIYTDEIFGPV+ +VRA DYEEAL LP+EHEYGNG Sbjct 361 --EDADLSGGYYVGPTLFDHVTKDMSIYTDEIFGPVVTIVRAHDYEEALALPTEHEYGNG 418 Query 425 VAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFY 484 V+IFTRDGD ARDF SRV+VGMVGVNVP+PVPVAYHTFGGWKRSGFGDLNQHGPA+I FY Sbjct 419 VSIFTRDGDTARDFTSRVEVGMVGVNVPVPVPVAYHTFGGWKRSGFGDLNQHGPASIMFY 478 Query 485 TKVKTVTSRWPSGIKDGAEFVIPTM 509 TK KTVTSRWPSGIK+GA+F +P M Sbjct 479 TKTKTVTSRWPSGIKEGADFAMPQM 503 >gi|134098042|ref|YP_001103703.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Saccharopolyspora erythraea NRRL 2338] gi|291007194|ref|ZP_06565167.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Saccharopolyspora erythraea NRRL 2338] gi|133910665|emb|CAM00778.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Saccharopolyspora erythraea NRRL 2338] Length=499 Score = 749 bits (1935), Expect = 0.0, Method: Compositional matrix adjust. Identities = 372/510 (73%), Positives = 429/510 (85%), Gaps = 11/510 (2%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MT ++ HFI G+R AG S DVFDPN+G++QA+V +A K +++AAVA A EAQ GWAA Sbjct 1 MTNELGHFIGGKRVAGTSGSFGDVFDPNSGKVQARVALAAKEEVEAAVADAAEAQPGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 NPQ+RARVLMRF++LVND +D LA LL+ EHGKT+ADA+GD+QRG+EV+EF GIPHLL Sbjct 61 QNPQKRARVLMRFLQLVNDEMDSLARLLASEHGKTVADAKGDIQRGLEVVEFATGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEY+E AG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKA PA+ACGNAFVLKPSERDP Sbjct 121 KGEYSENAGTGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAAPAIACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVP+RLAELFIEAGLPAG+F VV+GDK AVDA+L P I+AVGFVGSS IA+YIY+ AAA Sbjct 181 SVPLRLAELFIEAGLPAGIFNVVNGDKTAVDAVLTDPRIQAVGFVGSSPIAEYIYSTAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKRAQCFGGAKNHMIVMPDADLDQAVDAL+GAGYGSAGERCMAISVAVPVG+ TA+ L Sbjct 241 HGKRAQCFGGAKNHMIVMPDADLDQAVDALVGAGYGSAGERCMAISVAVPVGEPTADALV 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 +L+ER+ L++G S D AD+GPL+T A RV D +G GV GAEL+VDGRD Sbjct 301 EKLVERVRKLKIGTSFDADADFGPLITKQAWQRVHDLVGVGVEEGAELLVDGRD------ 354 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F L EG+ E GFF+G +LFD V M IY +EIFGPVL +VRA DYEEALRLP+E+E Sbjct 355 -FSL-EGN---EDGFFMGASLFDRVKPDMRIYREEIFGPVLSVVRAADYEEALRLPTENE 409 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGDAAR+F SRV GMVGVNVPIPVP+AYHTFGGWKRSGFGDLNQHGP + Sbjct 410 YGNGVAIFTRDGDAAREFTSRVNTGMVGVNVPIPVPIAYHTFGGWKRSGFGDLNQHGPDS 469 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS 510 I+FYTK KTVTSRWPSG+K+GA F IPTM+ Sbjct 470 IRFYTKTKTVTSRWPSGLKEGASFTIPTMN 499 >gi|319950405|ref|ZP_08024321.1| methylmalonate-semialdehyde dehydrogenase [Dietzia cinnamea P4] gi|319435921|gb|EFV91125.1| methylmalonate-semialdehyde dehydrogenase [Dietzia cinnamea P4] Length=508 Score = 749 bits (1933), Expect = 0.0, Method: Compositional matrix adjust. Identities = 364/506 (72%), Positives = 427/506 (85%), Gaps = 4/506 (0%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 Q+ H+I+G R A R+ DV +P+TG+ QA VP+A +++D +A A AQK WAA NP Sbjct 6 QVEHYINGARVAATGGRTQDVLNPSTGKAQAVVPLATTAEVDDVIAKAAAAQKAWAAQNP 65 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 Q+RARVLMRF++LVN + ELAELL+ EHGKT DA+GD+QRG+EVIEF +GIPHLLKGE Sbjct 66 QKRARVLMRFVDLVNQNMQELAELLAIEHGKTTPDAKGDIQRGLEVIEFAIGIPHLLKGE 125 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTE AG G+DVYS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAFVLKPSERDPSVP Sbjct 126 YTENAGTGVDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFVLKPSERDPSVP 185 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 VRLAELF EAGLP G+FQVVHGDKEAVDAIL++ I+AVGFVGS+ IAQYIY AA TGK Sbjct 186 VRLAELFTEAGLPDGIFQVVHGDKEAVDAILNNDTIQAVGFVGSTPIAQYIYENAARTGK 245 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH I+MPDAD+DQ DAL+GAG+GSAGERCMAISVAVPVG+ TAE+L +L Sbjct 246 RAQCFGGAKNHAIIMPDADMDQVADALVGAGFGSAGERCMAISVAVPVGEGTAEKLIEKL 305 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 + ++ L+VGHS DP++DYGPLVT + RV DYI QG AGAE++VDGR + +F Sbjct 306 LPKVKELKVGHSHDPQSDYGPLVTPESKERVLDYISQGADAGAEVLVDGRGVGAYTDSF- 364 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 ++ GG+F+GPTL D V MS+YTDEIFGPVL +V A+D+EEAL LPS+HEYGN Sbjct 365 ---NGEDISGGYFVGPTLLDKVTTDMSVYTDEIFGPVLSIVHAKDFEEALALPSDHEYGN 421 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAAR+FVSRV+VGMVGVNVPIPVP+AYHTFGGWK+SGFGDLNQHGP +I+F Sbjct 422 GVAIFTRDGDAAREFVSRVEVGMVGVNVPIPVPIAYHTFGGWKKSGFGDLNQHGPESIKF 481 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTM 509 Y+KVKTVT RWPSGIKDGAEFVIPTM Sbjct 482 YSKVKTVTQRWPSGIKDGAEFVIPTM 507 >gi|169628282|ref|YP_001701931.1| methylmalonic acid semialdehyde dehydrogenase MmsA [Mycobacterium abscessus ATCC 19977] gi|169240249|emb|CAM61277.1| Probable methylmalonic acid semialdehyde dehydrogenase MmsA [Mycobacterium abscessus] Length=501 Score = 738 bits (1904), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/506 (72%), Positives = 415/506 (83%), Gaps = 11/506 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 Q++HF+ G+ G S R ADV+DP G+ +VP+A S+++AA+++A EAQ GWAA NP Sbjct 6 QLTHFVAGKPVPGTSGRFADVYDPTQGKPVRQVPLADVSEVEAAISNAAEAQPGWAARNP 65 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 Q+RARVL +F++LV ID+LA +LS+EHGKTLADA+GD++RG+EV EF GIPHL+KGE Sbjct 66 QQRARVLAKFVDLVRAEIDDLAAMLSQEHGKTLADAKGDIERGLEVCEFATGIPHLIKGE 125 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YT GAG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP Sbjct 126 YTSGAGTGIDVYSIRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 185 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF+EAGLP GVF VV+GDK AVDA+LH P + AVGFVGS+ IAQYIY A A GK Sbjct 186 LRLAELFLEAGLPPGVFNVVNGDKTAVDALLHDPRVAAVGFVGSTPIAQYIYETATANGK 245 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNHMI+MPDAD+DQA+DALIGAGYGSAGERCMAISVAVPVG+ TAERL L Sbjct 246 RAQCFGGAKNHMIIMPDADIDQAIDALIGAGYGSAGERCMAISVAVPVGEATAERLVDGL 305 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 +R L VG SLD D+GPLV AL RVRDYI GVA GAELV+DGRD D Sbjct 306 TKRARELVVGASLDEGVDFGPLVGADALKRVRDYIDIGVAEGAELVLDGRDLTVD----- 360 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + GFFIG +LFDHV M IY +EIFGPV+ +VRA+DY+EA+RLPSEHE+GN Sbjct 361 ------GHKDGFFIGASLFDHVTPEMRIYKEEIFGPVVSVVRAKDYDEAVRLPSEHEFGN 414 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGD ARDF ++V GMVGVNVPIPVPVAYHTFGGWK SGFGDLNQHGP +I+F Sbjct 415 GVAIFTRDGDTARDFCAKVNTGMVGVNVPIPVPVAYHTFGGWKASGFGDLNQHGPDSIRF 474 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTM 509 YTK KTVT RWPSGIK+GA FVIPTM Sbjct 475 YTKTKTVTQRWPSGIKEGASFVIPTM 500 >gi|325673564|ref|ZP_08153255.1| methylmalonate-semialdehyde dehydrogenase [Rhodococcus equi ATCC 33707] gi|325555585|gb|EGD25256.1| methylmalonate-semialdehyde dehydrogenase [Rhodococcus equi ATCC 33707] Length=501 Score = 737 bits (1903), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/507 (73%), Positives = 422/507 (84%), Gaps = 12/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 ++SHFI G+R G S R ADVFDPNTGQ+QA+VP+A +S+ +AA+A+A +AQK WA+WNP Sbjct 5 ELSHFIGGKRIPGTSGRFADVFDPNTGQVQARVPLADRSETEAAIANAADAQKEWASWNP 64 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARVLMRF++L+ + +D LA LLS EHGKT+ DA+GD+QRG+EV+EF GIPHLLKGE Sbjct 65 QRRARVLMRFLQLIQEEMDPLARLLSSEHGKTIPDAKGDIQRGLEVVEFATGIPHLLKGE 124 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAG GIDV+S+RQPLGVVAGITPFNFPAMIPLWKA PALACGNAFVLKPSERDPSVP Sbjct 125 YTEGAGSGIDVFSMRQPLGVVAGITPFNFPAMIPLWKAAPALACGNAFVLKPSERDPSVP 184 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF+EAGLP GVF VV+GDK AVD +L P IKAVGFVGS+ IAQYIY AAA GK Sbjct 185 LRLAELFLEAGLPPGVFNVVNGDKGAVDTLLTDPRIKAVGFVGSTPIAQYIYETAAAHGK 244 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH IVMPDADLDQ DAL+GAGYGSAGERCMAISVAVPVG++TA+ L A+L Sbjct 245 RAQCFGGAKNHAIVMPDADLDQVADALVGAGYGSAGERCMAISVAVPVGEETADALVAKL 304 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 ER+ LR+G S D AD+GP+V+ AL RV Y+ GV GAELV+DGR F Sbjct 305 SERVAKLRIGRSDDETADFGPVVSKDALDRVDGYVQIGVDEGAELVIDGRG-------FT 357 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 L EG N GFF G TLFD V M IY +EIFGPVL +VRA DYEEALRLP+EHEYGN Sbjct 358 L-EGHEN---GFFAGATLFDRVTPEMRIYKEEIFGPVLQVVRAHDYEEALRLPTEHEYGN 413 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGD ARDF SRV+VGMVGVNVPIPVP+AYHTFGGWKRSGFGDLNQHGP +I+F Sbjct 414 GVAIFTRDGDTARDFCSRVEVGMVGVNVPIPVPIAYHTFGGWKRSGFGDLNQHGPDSIRF 473 Query 484 YTKVKTVTSRWPSGIKDGAE-FVIPTM 509 YTK KTVT RWPSG K+ ++ FVIPTM Sbjct 474 YTKTKTVTQRWPSGFKEHSDHFVIPTM 500 >gi|312139133|ref|YP_004006469.1| methylmalonic acid semialdehyde dehydrogenase mmsa [Rhodococcus equi 103S] gi|311888472|emb|CBH47784.1| methylmalonic acid semialdehyde dehydrogenase MmsA [Rhodococcus equi 103S] Length=501 Score = 736 bits (1901), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/507 (73%), Positives = 422/507 (84%), Gaps = 12/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 ++SHFI G+R G S R ADVFDPNTGQ+QA+VP+A +S+ +AA+A+A +AQK WA+WNP Sbjct 5 ELSHFIGGKRIPGTSGRFADVFDPNTGQVQARVPLADRSETEAAIANAADAQKEWASWNP 64 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARVLMRF++L+ + +D LA LLS EHGKT+ DA+GD+QRG+EV+EF GIPHLLKGE Sbjct 65 QRRARVLMRFLQLIQEEMDPLARLLSSEHGKTIPDAKGDIQRGLEVVEFATGIPHLLKGE 124 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAG GIDV+S+RQPLGVVAGITPFNFPAMIPLWKA PALACGNAFVLKPSERDPSVP Sbjct 125 YTEGAGSGIDVFSMRQPLGVVAGITPFNFPAMIPLWKAAPALACGNAFVLKPSERDPSVP 184 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF+EAGLP GVF VV+GDK AVD +L P IKAVGFVGS+ IAQYIY AAA GK Sbjct 185 LRLAELFLEAGLPPGVFNVVNGDKGAVDTLLTDPRIKAVGFVGSTPIAQYIYETAAAHGK 244 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH IVMPDADLDQ DAL+GAGYGSAGERCMAISVAVPVG++TA+ L A+L Sbjct 245 RAQCFGGAKNHAIVMPDADLDQVADALVGAGYGSAGERCMAISVAVPVGEETADALVAKL 304 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 ER+ LR+G S D AD+GP+V+ AL RV Y+ GV GAEL++DGR F Sbjct 305 SERVAKLRIGRSDDETADFGPVVSKDALDRVDGYVQIGVDEGAELIIDGRG-------FT 357 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 L EG N GFF G TLFD V M IY +EIFGPVL +VRA DYEEALRLP+EHEYGN Sbjct 358 L-EGHEN---GFFAGATLFDRVTPEMRIYKEEIFGPVLQVVRAHDYEEALRLPTEHEYGN 413 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGD ARDF SRV+VGMVGVNVPIPVP+AYHTFGGWKRSGFGDLNQHGP +I+F Sbjct 414 GVAIFTRDGDTARDFCSRVEVGMVGVNVPIPVPIAYHTFGGWKRSGFGDLNQHGPDSIRF 473 Query 484 YTKVKTVTSRWPSGIKDGAE-FVIPTM 509 YTK KTVT RWPSG K+ A+ FVIPTM Sbjct 474 YTKTKTVTQRWPSGFKEHADHFVIPTM 500 >gi|226360659|ref|YP_002778437.1| methylmalonate-semialdehyde dehydrogenase [Rhodococcus opacus B4] gi|226239144|dbj|BAH49492.1| methylmalonate-semialdehyde dehydrogenase [Rhodococcus opacus B4] Length=500 Score = 736 bits (1900), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/511 (71%), Positives = 417/511 (82%), Gaps = 12/511 (2%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 M ++SHF+ G+R G S + DV+DPNTG++QA+VP+A K++ +A +A+AVEAQ+ WA Sbjct 1 MVQELSHFVGGKRVPGASNKFGDVYDPNTGEVQARVPLADKAETEAIIANAVEAQREWAL 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 +NPQ+RARVLM+F++LV D +D LA LLS EHGKT+ DA+GD+QRG+EVIEF LG PHLL Sbjct 61 FNPQKRARVLMKFLQLVQDEMDSLARLLSSEHGKTIPDAKGDIQRGLEVIEFALGAPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTE AG GIDVYS+RQPLGVVAGITPFNFPAMIPLWKAGPALA GNAF+LKPSERDP Sbjct 121 KGEYTESAGTGIDVYSMRQPLGVVAGITPFNFPAMIPLWKAGPALAAGNAFILKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVP+RLAELF+EAGLPAGVF VV+GDKE VD +L +KAVGFVGS+ IAQYIY AAA Sbjct 181 SVPLRLAELFLEAGLPAGVFNVVNGDKEVVDVLLTDDRVKAVGFVGSTPIAQYIYETAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKRAQCFGGAKNH IVMPDADLD+ DALIGAGYGSAGERCMAISVAVPVG++TA+ L Sbjct 241 HGKRAQCFGGAKNHAIVMPDADLDEVADALIGAGYGSAGERCMAISVAVPVGEETADALV 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 A+L ER+ L++G S D AD+GPLV+ A+ RV +YI G+ GAE VVDGR Sbjct 301 AKLTERVGKLKIGRSDDEGADFGPLVSKDAVERVNNYIQIGLDEGAEAVVDGRG------ 354 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F L EG N GFF G TLFD V M +Y +EIFGPVL + RA DYEEALRLP+EHE Sbjct 355 -FTL-EGHEN---GFFAGATLFDKVTTDMRVYKEEIFGPVLLVARAADYEEALRLPTEHE 409 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 YGNGVAIFTRDGD ARDF SRVQVGMVGVNVPIPVP+AYHTFGGWKRSGFGDLNQHGP + Sbjct 410 YGNGVAIFTRDGDTARDFCSRVQVGMVGVNVPIPVPIAYHTFGGWKRSGFGDLNQHGPDS 469 Query 481 IQFYTKVKTVTSRWPSGIKDGAE-FVIPTMS 510 +FYTK KTVT RWPSG K+ FVIPTM+ Sbjct 470 FRFYTKTKTVTQRWPSGKKEETNHFVIPTMN 500 >gi|170740706|ref|YP_001769361.1| methylmalonate-semialdehyde dehydrogenase [Methylobacterium sp. 4-46] gi|168194980|gb|ACA16927.1| methylmalonate-semialdehyde dehydrogenase [Methylobacterium sp. 4-46] Length=498 Score = 733 bits (1891), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/507 (69%), Positives = 416/507 (83%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 ++ HFI G+ AG+S R +D+F P TG++ ++ +A +++ A+ +A AQ WAA NP Sbjct 3 EVGHFIGGEHVAGRSGRHSDIFQPMTGEVIGRLALASAAEVRDAIENAARAQTVWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARV+MRF++LV D LAELL+REHGKTL DA+GD+QRG+EV+EF GIPHLLKGE Sbjct 63 QRRARVMMRFLDLVARETDSLAELLAREHGKTLPDAKGDIQRGVEVVEFACGIPHLLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGP ID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPAIDMYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAEL IEAGLPAG+ VV+GDKEAVDAIL I+AVGFVGSSDIAQY+YA A A GK Sbjct 183 MRLAELMIEAGLPAGILNVVNGDKEAVDAILDDDLIQAVGFVGSSDIAQYVYARATAQGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNHMI+MPDAD+DQAVDAL+GAGYGSAGERCMA+SVAVPVG++TA+ L ++L Sbjct 243 RAQCFGGAKNHMIIMPDADMDQAVDALMGAGYGSAGERCMAVSVAVPVGEKTADALMSKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 + R+ +L++G S DP ADYGPLVT AAL RVR+Y+ GV GA+LVVDGR Sbjct 303 VPRVESLKIGPSTDPSADYGPLVTRAALERVRNYVEIGVREGAKLVVDGRGFTMQ----- 357 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 E GF++G LFDHV M IY +EIFGPVL +VRA+DY EALRLPSEHEYGN Sbjct 358 ------GYENGFYLGGCLFDHVTPQMRIYKEEIFGPVLSVVRAKDYAEALRLPSEHEYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWKRSGFGDLNQHGP AI+F Sbjct 412 GVAIFTRDGDAARDFAAKVNVGMVGINVPIPVPLAYYTFGGWKRSGFGDLNQHGPDAIRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVT+RWPSG+K+GA+F +P M Sbjct 472 YTKTKTVTARWPSGVKEGAQFSMPVMQ 498 >gi|323137059|ref|ZP_08072139.1| methylmalonate-semialdehyde dehydrogenase [Methylocystis sp. ATCC 49242] gi|322397820|gb|EFY00342.1| methylmalonate-semialdehyde dehydrogenase [Methylocystis sp. ATCC 49242] Length=498 Score = 728 bits (1880), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/507 (69%), Positives = 415/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 ++ HFI G+ G+S R A+V++P TG + A P+A K+++ AAV +A+ AQ GWAA NP Sbjct 3 ELGHFIGGKFLKGESGRFAEVYEPMTGSVAALAPLASKAEVRAAVENAIAAQPGWAAVNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVLM+F+ELV+ D LA LL+REHGKT+ADA+GD+QRG+EVIEF LG+PHL+KGE Sbjct 63 QRRGRVLMKFLELVSRETDSLATLLAREHGKTIADAKGDIQRGVEVIEFALGVPHLMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YT+ AG G+D+YS+RQPLGVVAG+TPFNFPAMIP+WK GPALACGNAF+LKPSERDPSVP Sbjct 123 YTDSAGSGVDMYSMRQPLGVVAGVTPFNFPAMIPMWKFGPALACGNAFILKPSERDPSVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAEL I+AGLP GV VV+GDKEAVDA+L PDIKA+GFVGS+ +AQY+YA AAATGK Sbjct 183 LRLAELMIDAGLPPGVLNVVNGDKEAVDALLDDPDIKAIGFVGSTPVAQYVYARAAATGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH+++MPDAD++QAVDALIGA YGSAGERCMA+SVAVPVG+ TA L RL Sbjct 243 RAQCFGGAKNHLVIMPDADMNQAVDALIGAAYGSAGERCMAVSVAVPVGEATANELVKRL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D AD+GPLVT L +V +Y+ GVA GA+L+VDGR+ F Sbjct 303 IPRVESLKIGLSTDEAADFGPLVTKTHLEKVENYVSLGVAEGAKLLVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GFFIG LFD V M IY +EIFGPVL +VR +Y +AL L +EHEYGN Sbjct 356 M----QGYENGFFIGGCLFDEVTPRMHIYREEIFGPVLSVVRVENYAQALTLVNEHEYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAAR+FVSRVQVGMVGVN PIP P+AYHTFGGWKRS FGDLNQHGP +I+F Sbjct 412 GVAIFTRDGDAAREFVSRVQVGMVGVNTPIPTPLAYHTFGGWKRSMFGDLNQHGPDSIRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSGIKDGA FVIPTMS Sbjct 472 YTKTKTVTSRWPSGIKDGASFVIPTMS 498 >gi|27379065|ref|NP_770594.1| methylmalonate-semialdehyde dehydrogenase [Bradyrhizobium japonicum USDA 110] gi|27352215|dbj|BAC49219.1| methylmalonate-semialdehyde dehydrogenase [Bradyrhizobium japonicum USDA 110] Length=498 Score = 728 bits (1879), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/507 (70%), Positives = 413/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ G S R+ADVF+P TG +QAKV +A K+++ AAV +A AQ WAA NP Sbjct 3 SIGHFIGGKEVKGTSGRTADVFEPMTGDVQAKVALASKAEVRAAVENARAAQPEWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARV+M+F+ELV D+LAELL+REHGKT+ DA+GD+QRG+EV EF GIPHL+KGE Sbjct 63 QRRARVMMKFVELVQRDYDKLAELLAREHGKTVPDAKGDIQRGLEVAEFACGIPHLMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGPGID+YS+RQ LGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPGIDIYSMRQALGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 + LAEL +EAGLPAG+ VV+GDKEAVDAIL PDIKAVGFVGS+ IAQYIY AA TGK Sbjct 183 MLLAELMMEAGLPAGILNVVNGDKEAVDAILDDPDIKAVGFVGSTPIAQYIYERAAQTGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH I+MPDAD+DQAVDALIGAGYGSAGERCMA+SVAVPVG TA+RL +L Sbjct 243 RCQCFGGAKNHAIIMPDADMDQAVDALIGAGYGSAGERCMAVSVAVPVGKPTADRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S+DP ADYGPLVT A+ +V+ YI G+ GA L VDGR F Sbjct 303 IPRVESLKIGTSIDPSADYGPLVTREAVEKVKGYIDIGIKEGATLAVDGRG-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G +LFD+V M IY +EIFGPVL +VRA DY+EAL LPSEH+YGN Sbjct 356 M----QGYEKGFYLGGSLFDNVTKDMRIYKEEIFGPVLSVVRAHDYKEALALPSEHDYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +++F Sbjct 412 GVAIFTRDGDAARDFAAKVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSVRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+K+GAEF IP M Sbjct 472 YTKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|115524390|ref|YP_781301.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris BisA53] gi|115518337|gb|ABJ06321.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Rhodopseudomonas palustris BisA53] Length=498 Score = 728 bits (1878), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/507 (70%), Positives = 411/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG S R+ADVF+P TG +QA+V +A K+++ AA+ +A AQ W + NP Sbjct 3 SIGHFIAGREVAGTSGRTADVFEPMTGDVQAQVALASKAEMRAAIENAKAAQVEWGSTNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARVLM+F+EL D+LAELL+REHGKT+ DA+GD+QRG+EV+EF GIPHL+KGE Sbjct 63 QRRARVLMKFLELAQRDYDKLAELLAREHGKTIPDAKGDIQRGLEVVEFACGIPHLMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PALACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPALACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 + LA L +EAGLPAGV VV+GDKEAVDAIL PDIKAVGFVGSS IAQYIY AAATGK Sbjct 183 MALAALLVEAGLPAGVLNVVNGDKEAVDAILDDPDIKAVGFVGSSPIAQYIYERAAATGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH I+MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG TA+ L +L Sbjct 243 RAQCFGGAKNHAIIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGKPTADALMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ L++G S DP AD+GPLVT AAL RV+DY+ GV GA L VDGR F Sbjct 303 IPRVEALKIGPSTDPSADFGPLVTRAALDRVKDYVEIGVKEGATLAVDGRG-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFD+V M IY +EIFGPVL +VRA DY EAL LPSEH+YGN Sbjct 356 M----QGYENGFYMGGCLFDNVTRDMRIYKEEIFGPVLSVVRAHDYAEALALPSEHDYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF ++V VGM+G+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +++F Sbjct 412 GVAIFTRDGDAARDFAAKVNVGMIGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSVRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+K+GAEF IP M Sbjct 472 YTKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|110635647|ref|YP_675855.1| methylmalonate-semialdehyde dehydrogenase [acylating] [Mesorhizobium sp. BNC1] gi|110286631|gb|ABG64690.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Chelativorans sp. BNC1] Length=498 Score = 726 bits (1875), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/506 (69%), Positives = 410/506 (82%), Gaps = 11/506 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 +I HFI G+R AG+S S +V P G ++A V +A +++ AV +A AQ W A NP Sbjct 3 EIGHFIGGKRVAGKSGHSQNVMQPMDGTVRATVALASAAEVREAVENAKAAQIAWGATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVLM+F+ELV+ D LAELL+REHGKT+ DA+GD+QRG+EV+E C+G PH++KGE Sbjct 63 QRRVRVLMKFLELVHKEYDSLAELLAREHGKTILDAKGDIQRGLEVVEVCIGAPHMMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGPGID YS+RQPLGVVAGITPFNFPAMIPLWK PA+ACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPGIDTYSMRQPLGVVAGITPFNFPAMIPLWKIAPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +R+AELF+EAGLPAGV V++GDKEAVDAIL PDI+AVGFVGS+ IAQYIY A A GK Sbjct 183 MRIAELFVEAGLPAGVLNVINGDKEAVDAILDDPDIQAVGFVGSTPIAQYIYGRATANGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH+I+MPDADLDQ VDALIGAGYGSAGERCMA+SVAVPVG +TA+RL +L Sbjct 243 RAQCFGGAKNHLIIMPDADLDQTVDALIGAGYGSAGERCMAVSVAVPVGKETADRLVEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L+VG S D AD+GPLVT AL RV+ Y+ GV GA+LVVDGR+ F Sbjct 303 IPRVESLKVGPSTDASADFGPLVTKEALERVKGYVDIGVKEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFD V M IY +EIFGPVL +VRA +YEEALRLP++HE+GN Sbjct 356 M----QGYENGFYMGGCLFDEVTPEMRIYKEEIFGPVLSVVRANNYEEALRLPNDHEFGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF +RV VGMVG+NVPIPVP+AY+TFGGWK S FGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFAARVNVGMVGINVPIPVPIAYYTFGGWKASAFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTM 509 YTK KTVTSRWPSGIKDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGIKDGAEFVIPTM 497 >gi|90424586|ref|YP_532956.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris BisB18] gi|90106600|gb|ABD88637.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Rhodopseudomonas palustris BisB18] Length=498 Score = 726 bits (1874), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/507 (70%), Positives = 410/507 (81%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG S R ADVF+P TG++QA+V +A K+++ AAV A +AQ W A NP Sbjct 3 SIGHFIAGREVAGTSGRFADVFEPMTGEVQAQVALATKAELRAAVEDAKQAQLAWGATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARV+M+F+EL D+LAELL+ EHGKT+ DA+GD+QRG+EV+EF GIPHL+KGE Sbjct 63 QRRARVMMKFLELAQRDYDKLAELLASEHGKTVPDAKGDIQRGLEVVEFACGIPHLMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 + LA L IEAGLP G+ VV+GDKEAVDAIL PDI+AVGFVGSS IAQYIY AAATGK Sbjct 183 MALAALMIEAGLPPGILNVVNGDKEAVDAILDDPDIRAVGFVGSSPIAQYIYERAAATGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 RAQCFGGAKNH I+MPDADLD VDALIGAGYGSAGERCMAISVAVPVG TA+ L +L Sbjct 243 RAQCFGGAKNHAIIMPDADLDHTVDALIGAGYGSAGERCMAISVAVPVGKATADALMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ L++G S DP AD+GPLVT AAL RV+DY+ G+ GA L VDGRD F Sbjct 303 IPRVEALKIGPSTDPSADFGPLVTKAALQRVKDYVKVGIEEGATLAVDGRD-------FT 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 L E GF++G LFD+V M IY +EIFGPVL +VRA DY EAL LPS+H+YGN Sbjct 356 L----QGYENGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAHDYAEALALPSDHDYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +I+F Sbjct 412 GVAIFTRDGDAARDFAAKVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSIRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVT+RWPSG+K+GAEF IPTM Sbjct 472 YTKTKTVTARWPSGVKEGAEFSIPTMK 498 >gi|239832916|ref|ZP_04681245.1| methylmalonate-semialdehyde dehydrogenase [Ochrobactrum intermedium LMG 3301] gi|239825183|gb|EEQ96751.1| methylmalonate-semialdehyde dehydrogenase [Ochrobactrum intermedium LMG 3301] Length=536 Score = 723 bits (1866), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/507 (70%), Positives = 414/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+ADVF P G +QAKV +A K ++ AAV +A AQ WAA NP Sbjct 41 NIGHFIGGKHVAGKSGRTADVFQPLDGSVQAKVALATKDEVRAAVENAKAAQPAWAATNP 100 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR R+L +FIELV D LAELL+REHGKT+ADA+GD+QRG+EV+E CLG H+LKGE Sbjct 101 QRRVRILRKFIELVEAEYDSLAELLAREHGKTIADAKGDIQRGLEVVEVCLGAAHMLKGE 160 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAFVLKPSERDP VP Sbjct 161 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFVLKPSERDPGVP 220 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF+EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY + GK Sbjct 221 MRLAELFMEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCSNGK 280 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 281 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 340 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 341 IPRVESLKIGTSTDNSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 393 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFD+V M IY +EIFGPVL +VRA++YEEAL LP++HEYGN Sbjct 394 M----QGYEDGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAKNYEEALALPNDHEYGN 449 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQVGMVG+NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 450 GVAIFTRDGDAARDFASRVQVGMVGINVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 509 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 510 YTKTKTVTSRWPSGVKDGAEFVIPTMK 536 >gi|192292306|ref|YP_001992911.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris TIE-1] gi|192286055|gb|ACF02436.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris TIE-1] Length=498 Score = 723 bits (1866), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/506 (70%), Positives = 409/506 (81%), Gaps = 11/506 (2%) Query 5 ISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQ 64 + HFI G+ G+S R ADVF+P TG+++AKV +A K+++ AAV +A AQ W A NPQ Sbjct 4 VGHFIGGKEVEGKSGRFADVFEPMTGEVKAKVALATKAELRAAVENAKAAQPEWGATNPQ 63 Query 65 RRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEY 124 RRARVLM+F+ELV D+LAELL+REHGKT+ DA+GD+QRG+EV EF GIPHL+KGEY Sbjct 64 RRARVLMKFLELVQRDYDKLAELLAREHGKTIPDAKGDIQRGLEVAEFACGIPHLMKGEY 123 Query 125 TEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPV 184 TEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP+ Sbjct 124 TEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVPM 183 Query 185 RLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKR 244 LA L +EAGLP G+ VV+GDKEAVDAIL PDIKAVGFVGSS IAQYIY AA TGKR Sbjct 184 ALAALMLEAGLPPGILNVVNGDKEAVDAILDDPDIKAVGFVGSSPIAQYIYERAAQTGKR 243 Query 245 AQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARLI 304 AQCFGGAKNH I+MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG TAE L ++LI Sbjct 244 AQCFGGAKNHAIIMPDADIDQTVDALIGAGYGSAGERCMAISVAVPVGKATAEALMSKLI 303 Query 305 ERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGL 364 R+ L++G S DP ADYGPLVT AL RV++Y+ GV GA L VDGR F + Sbjct 304 PRVEALKIGPSTDPTADYGPLVTKEALERVKNYVDIGVKEGATLAVDGRG-------FKM 356 Query 365 PEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNG 424 E GF++G LFD+V M IY +EIFGPVL +VRA DY EAL LPS+H+YGNG Sbjct 357 ----QGYENGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAHDYAEALALPSDHDYGNG 412 Query 425 VAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFY 484 VAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +I+FY Sbjct 413 VAIFTRDGDAARDFAAKVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSIRFY 472 Query 485 TKVKTVTSRWPSGIKDGAEFVIPTMS 510 TK KTVTSRWPSG+K+GAEF IP M Sbjct 473 TKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|148254989|ref|YP_001239574.1| methylmalonate-semialdehyde dehydrogenase [Bradyrhizobium sp. BTAi1] gi|146407162|gb|ABQ35668.1| methylmalonate-semialdehyde dehydrogenase (acylating [Bradyrhizobium sp. BTAi1] Length=498 Score = 723 bits (1865), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/507 (70%), Positives = 414/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ G S R+ADVF+P TG +QAKV +A ++++ AAV +A AQ WAA NP Sbjct 3 SIGHFIGGKEVKGTSGRTADVFEPMTGDVQAKVALASRAELRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARV+M+F+EL D+LAELL+REHGKT+ DA+GD+QRG+EV+EF GIPHL+KGE Sbjct 63 QRRARVMMKFLELAQRDYDQLAELLAREHGKTVPDAKGDIQRGLEVVEFACGIPHLMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 ++LAEL IEAGLPAG+ VV+GDKEAVDAIL PDI AVGFVGSS IAQYIY AAA GK Sbjct 183 MKLAELMIEAGLPAGILNVVNGDKEAVDAILEDPDIMAVGFVGSSPIAQYIYERAAAHGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH IVMPDADLDQAVDALIGAGYGSAGERCMA+SVAVPVG TA+RL +L Sbjct 243 RCQCFGGAKNHAIVMPDADLDQAVDALIGAGYGSAGERCMAVSVAVPVGKTTADRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S+DP ADYGPLVT A+ RV++Y+ GV GA L VDGR F Sbjct 303 IPRVESLKIGTSIDPSADYGPLVTREAVERVKNYVDIGVKEGATLAVDGRG-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFD+V M IY +EIFGPVL +VRA+DY EAL LPSEH+YGN Sbjct 356 M----QGYENGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAKDYAEALALPSEHDYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +I+F Sbjct 412 GVAIFTRDGDAARDFAAKVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSIRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+K+GAEF IP M Sbjct 472 YTKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|265984837|ref|ZP_06097572.1| methylmalonate-semialdehyde dehydrogenase [Brucella sp. 83/13] gi|306839517|ref|ZP_07472325.1| methylmalonate-semialdehyde dehydrogenase [Brucella sp. NF 2653] gi|306844814|ref|ZP_07477399.1| methylmalonate-semialdehyde dehydrogenase [Brucella sp. BO1] gi|264663429|gb|EEZ33690.1| methylmalonate-semialdehyde dehydrogenase [Brucella sp. 83/13] gi|306274986|gb|EFM56756.1| methylmalonate-semialdehyde dehydrogenase [Brucella sp. BO1] gi|306405462|gb|EFM61733.1| methylmalonate-semialdehyde dehydrogenase [Brucella sp. NF 2653] Length=498 Score = 722 bits (1863), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/507 (70%), Positives = 413/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+AD+F P G +Q KV +A K ++ AAV +A AQ WAA NP Sbjct 3 NIGHFIGGKHVAGKSGRTADIFQPLDGTVQGKVALATKEEVRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVL +FIELV D LAELL+REHGKT+ADARGD+QRG+EV+E CLG H+LKGE Sbjct 63 QRRVRVLRKFIELVEAEYDSLAELLAREHGKTIADARGDIQRGLEVVEVCLGAAHMLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAF+LKPSERDP VP Sbjct 123 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF+EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY A GK Sbjct 183 MRLAELFLEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCANGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 243 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 + R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 303 VPRVESLKIGPSTDNSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFDHV M IY +EIFGPVL +VRA++YEEAL LPS+HE+GN Sbjct 356 M----QGYENGFYMGGCLFDHVTPDMRIYKEEIFGPVLSIVRAKNYEEALALPSDHEFGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQVGMVG+NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFASRVQVGMVGINVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGVKDGAEFVIPTMK 498 >gi|146340122|ref|YP_001205170.1| methylmalonate-semialdehyde dehydrogenase [Bradyrhizobium sp. ORS 278] gi|146192928|emb|CAL76935.1| Methylmalonate-semialdehyde dehydrogenase [Bradyrhizobium sp. ORS 278] Length=498 Score = 722 bits (1863), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/507 (70%), Positives = 413/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ G S R+ADVF+P TG +QAKV +A ++++ AAV +A AQ WAA NP Sbjct 3 SIGHFIGGKEVKGTSGRTADVFEPMTGDVQAKVALASRAELRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRRARV+M+F+EL D+LAELL+REHGKT+ DA+GD+QRG+EV+EF GIPHL+KGE Sbjct 63 QRRARVMMKFLELAQRDYDQLAELLAREHGKTVPDAKGDIQRGLEVVEFACGIPHLMKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 YTEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP Sbjct 123 YTEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 ++LAEL IEAGLP G+ VV+GDKEAVDAIL PDI AVGFVGSS IAQYIY AAA GK Sbjct 183 MKLAELMIEAGLPPGILNVVNGDKEAVDAILEDPDIMAVGFVGSSPIAQYIYERAAAHGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH IVMPDADLDQAVDALIGAGYGSAGERCMA+SVAVPVG TA+RL +L Sbjct 243 RCQCFGGAKNHAIVMPDADLDQAVDALIGAGYGSAGERCMAVSVAVPVGKTTADRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S+DP ADYGPLVT A+ RV++Y+ GV GA L VDGR F Sbjct 303 IPRVESLKIGTSIDPSADYGPLVTREAVERVKNYVDIGVKEGATLAVDGRG-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFD+V M IY +EIFGPVL +VRA+DY EAL LPSEH+YGN Sbjct 356 M----QGYENGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAKDYAEALALPSEHDYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF +RV VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +I+F Sbjct 412 GVAIFTRDGDAARDFAARVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSIRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+K+GAEF IP M Sbjct 472 YTKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|39936513|ref|NP_948789.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris CGA009] gi|39650369|emb|CAE28891.1| putative malonic semialdehyde oxidative decarboxylase [Rhodopseudomonas palustris CGA009] Length=498 Score = 721 bits (1862), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/506 (70%), Positives = 409/506 (81%), Gaps = 11/506 (2%) Query 5 ISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQ 64 + HFI G+ G+S R ADVF+P TG+++AKV +A K+++ AAV +A AQ W A NPQ Sbjct 4 VGHFIGGKEVEGKSGRFADVFEPMTGEVKAKVALATKAELRAAVENAKAAQPEWGATNPQ 63 Query 65 RRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEY 124 RRARVLM+F+ELV D+LAELL+REHGKT+ DA+GD+QRG+EV EF GIPHL+KGEY Sbjct 64 RRARVLMKFLELVQRDYDKLAELLAREHGKTIPDAKGDIQRGLEVAEFACGIPHLMKGEY 123 Query 125 TEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPV 184 TEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP+ Sbjct 124 TEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVPM 183 Query 185 RLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKR 244 LA L +EAGLP G+ VV+GDKEAVDAIL PDIKAVGFVGSS IAQYIY AA TGKR Sbjct 184 ALAALMLEAGLPPGILNVVNGDKEAVDAILDDPDIKAVGFVGSSPIAQYIYERAAQTGKR 243 Query 245 AQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARLI 304 AQCFGGAKNH I+MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG TA+ L ++LI Sbjct 244 AQCFGGAKNHAIIMPDADIDQTVDALIGAGYGSAGERCMAISVAVPVGKATADALMSKLI 303 Query 305 ERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGL 364 R+ L++G S DP ADYGPLVT AL RV++Y+ GV GA L VDGR F + Sbjct 304 PRVEALKIGPSTDPTADYGPLVTKEALERVKNYVDIGVKEGATLAVDGRG-------FKM 356 Query 365 PEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNG 424 E GF++G LFD+V M IY +EIFGPVL +VRA DY EAL LPS+H+YGNG Sbjct 357 ----QGYENGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAHDYAEALSLPSDHDYGNG 412 Query 425 VAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFY 484 VAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +I+FY Sbjct 413 VAIFTRDGDAARDFAAKVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSIRFY 472 Query 485 TKVKTVTSRWPSGIKDGAEFVIPTMS 510 TK KTVTSRWPSG+K+GAEF IP M Sbjct 473 TKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|316933287|ref|YP_004108269.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris DX-1] gi|315601001|gb|ADU43536.1| methylmalonate-semialdehyde dehydrogenase [Rhodopseudomonas palustris DX-1] Length=498 Score = 721 bits (1860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/506 (69%), Positives = 409/506 (81%), Gaps = 11/506 (2%) Query 5 ISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQ 64 + HFI G+ G+S R ADVF+P TG+++AKV +A K+++ AAV +A AQ W A NPQ Sbjct 4 VGHFIGGKEVEGKSGRFADVFEPMTGEVKAKVALATKAELRAAVENAKAAQPEWGATNPQ 63 Query 65 RRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEY 124 RRARVLM+F+ELV D+LAELL+REHGKT+ DA+GD+QRG+EV EF GIPHL+KGEY Sbjct 64 RRARVLMKFLELVQRDYDKLAELLAREHGKTIPDAKGDIQRGLEVAEFACGIPHLMKGEY 123 Query 125 TEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPV 184 TEGAGPGID+YS+RQPLGVVAGITPFNFPAMIP+WK PA+ACGNAF+LKPSERDP VP+ Sbjct 124 TEGAGPGIDIYSMRQPLGVVAGITPFNFPAMIPMWKFAPAIACGNAFILKPSERDPGVPM 183 Query 185 RLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKR 244 LA L +EAGLP G+ VV+GDKEAVDAIL PDIKAVGFVGSS IAQYIY AA TGKR Sbjct 184 ALAALMLEAGLPPGILNVVNGDKEAVDAILDDPDIKAVGFVGSSPIAQYIYERAAQTGKR 243 Query 245 AQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARLI 304 AQCFGGAKNH I+MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG TA+ L ++LI Sbjct 244 AQCFGGAKNHAIIMPDADIDQTVDALIGAGYGSAGERCMAISVAVPVGKATADALMSKLI 303 Query 305 ERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGL 364 R+ L++G S DP ADYGPLVT AL RV++Y+ GV GA L VDGR F + Sbjct 304 PRVEALKIGPSTDPTADYGPLVTKEALERVKNYVEIGVQEGATLAVDGRG-------FKM 356 Query 365 PEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNG 424 E GF++G LFD+V M IY +EIFGPVL +VRA DY EAL LPS+H+YGNG Sbjct 357 ----QGYENGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAHDYAEALALPSDHDYGNG 412 Query 425 VAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFY 484 VAIFTRDGDAARDF ++V VGMVG+NVPIPVP+AY+TFGGWK+SGFGDLNQHGP +++FY Sbjct 413 VAIFTRDGDAARDFAAKVNVGMVGINVPIPVPIAYYTFGGWKKSGFGDLNQHGPDSVRFY 472 Query 485 TKVKTVTSRWPSGIKDGAEFVIPTMS 510 TK KTVTSRWPSG+K+GAEF IP M Sbjct 473 TKTKTVTSRWPSGVKEGAEFSIPLMK 498 >gi|23502685|ref|NP_698812.1| methylmalonic acid semialdehyde dehydrogenase [Brucella suis 1330] gi|62290694|ref|YP_222487.1| MmsA, methylmalonic acid semialdehyde dehydrogenase [Brucella abortus bv. 1 str. 9-941] gi|82700610|ref|YP_415184.1| aldehyde dehydrogenase [Brucella melitensis biovar Abortus 2308] 42 more sequence titles Length=498 Score = 721 bits (1860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/507 (71%), Positives = 412/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+AD+F P G +Q KV +A K ++ AAV +A AQ WAA NP Sbjct 3 NIGHFIGGKHVAGKSGRTADIFQPLDGTVQGKVALATKEEVRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVL +FIELV D LAELL+REHGKT+ADARGD+QRG+EV+E CLG H+LKGE Sbjct 63 QRRVRVLRKFIELVEAEYDSLAELLAREHGKTIADARGDIQRGLEVVEVCLGAAHMLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAF+LKPSERDP VP Sbjct 123 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY A GK Sbjct 183 MRLAELFQEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCANGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 243 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 303 IPRVESLKIGPSTDNSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFDHV M IY +EIFGPVL +VRA++YEEAL LPS+HE+GN Sbjct 356 M----QGYENGFYMGGCLFDHVTPDMRIYKEEIFGPVLSIVRAKNYEEALALPSDHEFGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQVGMVG+NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFASRVQVGMVGINVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGVKDGAEFVIPTMK 498 >gi|161619751|ref|YP_001593638.1| methylmalonate-semialdehyde dehydrogenase [Brucella canis ATCC 23365] gi|260568902|ref|ZP_05839370.1| ATP/GTP-binding site-containing protein A [Brucella suis bv. 4 str. 40] gi|161336562|gb|ABX62867.1| methylmalonate-semialdehyde dehydrogenase [Brucella canis ATCC 23365] gi|260154286|gb|EEW89368.1| ATP/GTP-binding site-containing protein A [Brucella suis bv. 4 str. 40] Length=498 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/507 (71%), Positives = 412/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+AD+F P G +Q KV +A K ++ AAV +A AQ WAA NP Sbjct 3 NIGHFIGGKHVAGKSGRTADIFQPLDGTVQGKVALATKEEVRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVL +FIELV D LAELL+REHGKT+ADARGD+QRG+EV+E CLG H+LKGE Sbjct 63 QRRVRVLRKFIELVEAEYDSLAELLAREHGKTIADARGDIQRGLEVVEVCLGAAHMLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAF+LKPSERDP VP Sbjct 123 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY A GK Sbjct 183 MRLAELFQEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCANGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 243 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 303 IPRVESLKIGPSTDDSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFDHV M IY +EIFGPVL +VRA++YEEAL LPS+HE+GN Sbjct 356 M----QGYENGFYMGGCLFDHVTPDMRIYKEEIFGPVLSIVRAKNYEEALALPSDHEFGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQVGMVG+NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFASRVQVGMVGINVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGVKDGAEFVIPTMK 498 >gi|148560620|ref|YP_001259669.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Brucella ovis ATCC 25840] gi|148371877|gb|ABQ61856.1| methylmalonate-semialdehyde dehydrogenase (acylating) [Brucella ovis ATCC 25840] Length=498 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/507 (70%), Positives = 412/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+AD+F P G +Q KV +A K ++ AAV +A AQ WAA NP Sbjct 3 NIGHFIGGKHVAGKSGRTADIFQPLDGTVQGKVALATKEEVRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVL +FIELV D LAELL+REHGKT+ADARGD+QRG+EV+E CLG H+LKGE Sbjct 63 QRRVRVLRKFIELVEAEYDSLAELLAREHGKTIADARGDIQRGLEVVEVCLGAAHMLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAF+LKPSERDP VP Sbjct 123 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY A GK Sbjct 183 MRLAELFQEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCANGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 243 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 303 IPRVESLKIGPSTDNSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFDHV M IY +EIFGPVL +VRA++YEEAL LPS+HE+GN Sbjct 356 M----QGYENGFYMGGCLFDHVTPDMRIYKEEIFGPVLSIVRAKNYEEALALPSDHEFGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQ+GMVG+NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFASRVQIGMVGINVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGVKDGAEFVIPTMK 498 >gi|261754231|ref|ZP_05997940.1| methylmalonate-semialdehyde dehydrogenase [Brucella suis bv. 3 str. 686] gi|261743984|gb|EEY31910.1| methylmalonate-semialdehyde dehydrogenase [Brucella suis bv. 3 str. 686] Length=498 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/507 (71%), Positives = 411/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+AD+F P G +Q KV +A K ++ AAV +A AQ WAA NP Sbjct 3 NIGHFIGGKHVAGKSGRTADIFQPLDGTVQGKVALATKEEVRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR RVL +FIELV D LAELL+REHGKT+ADARGD+QRG+EV+E CLG H+LKGE Sbjct 63 QRRVRVLRKFIELVEAEYDSLAELLAREHGKTIADARGDIQRGLEVVEVCLGAAHMLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAF+LKPSERDP VP Sbjct 123 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY A GK Sbjct 183 MRLAELFQEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCANGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 243 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 303 IPRVESLKIGPSTDDSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFDHV M IY +EIFGPVL +VRA++YEEAL LPS+HE+GN Sbjct 356 M----QGYENGFYMGGCLFDHVTPDMRIYKEEIFGPVLSIVRAKNYEEALALPSDHEFGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQVGMVG NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFASRVQVGMVGTNVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGVKDGAEFVIPTMK 498 >gi|153008402|ref|YP_001369617.1| methylmalonate-semialdehyde dehydrogenase [Ochrobactrum anthropi ATCC 49188] gi|151560290|gb|ABS13788.1| methylmalonate-semialdehyde dehydrogenase [Ochrobactrum anthropi ATCC 49188] Length=498 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/507 (70%), Positives = 413/507 (82%), Gaps = 11/507 (2%) Query 4 QISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNP 63 I HFI G+ AG+S R+ADVF P G +Q KV +A K ++ AAV +A AQ WAA NP Sbjct 3 NIGHFIGGKHVAGKSGRTADVFQPLDGSVQGKVALATKEEVRAAVENAKAAQPAWAATNP 62 Query 64 QRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGE 123 QRR R+L +F+ELV D LAELL+REHGKT+ADA+GD+QRG+EV+E CLG H+LKGE Sbjct 63 QRRVRILRKFVELVEAEYDSLAELLAREHGKTIADAKGDIQRGLEVVEVCLGAAHMLKGE 122 Query 124 YTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVP 183 +T+ AG GID YS+RQPLGVVAGITPFNFPAMIPLWKAGPA+ACGNAF+LKPSERDP VP Sbjct 123 FTDNAGTGIDTYSMRQPLGVVAGITPFNFPAMIPLWKAGPAIACGNAFILKPSERDPGVP 182 Query 184 VRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGK 243 +RLAELF+EAGLPAG+F VV+GDKE+VDA+L PD++A+GFVGS+ IAQYIY + GK Sbjct 183 MRLAELFMEAGLPAGIFNVVNGDKESVDALLDDPDVQAIGFVGSTPIAQYIYGRGCSNGK 242 Query 244 RAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARL 303 R QCFGGAKNH+++MPDAD+DQ VDALIGAGYGSAGERCMAISVAVPVG+ TA RL +L Sbjct 243 RVQCFGGAKNHLLIMPDADMDQTVDALIGAGYGSAGERCMAISVAVPVGEDTANRLMEKL 302 Query 304 IERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFG 363 I R+ +L++G S D ADYGPLVT AAL RVR Y+ GV GA+LVVDGR+ F Sbjct 303 IPRVESLKIGTSTDNSADYGPLVTKAALDRVRGYVDLGVEEGAKLVVDGRN-------FK 355 Query 364 LPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGN 423 + E GF++G LFD+V M IY +EIFGPVL +VRA++YEEAL LP++HEYGN Sbjct 356 M----QGYEDGFYMGGCLFDNVTKDMRIYKEEIFGPVLSVVRAKNYEEALALPNDHEYGN 411 Query 424 GVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQF 483 GVAIFTRDGDAARDF SRVQVGMVG+NVPIPVP+AY+TFGGWK SGFGDLNQHGP A +F Sbjct 412 GVAIFTRDGDAARDFASRVQVGMVGINVPIPVPIAYYTFGGWKASGFGDLNQHGPDAFRF 471 Query 484 YTKVKTVTSRWPSGIKDGAEFVIPTMS 510 YTK KTVTSRWPSG+KDGAEFVIPTM Sbjct 472 YTKTKTVTSRWPSGVKDGAEFVIPTMK 498 >gi|289573371|ref|ZP_06453598.1| methylmalonate-semialdehyde dehydrogenase mmsA [Mycobacterium tuberculosis K85] gi|289537802|gb|EFD42380.1| methylmalonate-semialdehyde dehydrogenase mmsA [Mycobacterium tuberculosis K85] Length=359 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/357 (100%), Positives = 357/357 (100%), Gaps = 0/357 (0%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA Sbjct 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL Sbjct 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP Sbjct 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA Sbjct 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR Sbjct 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRAS 357 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRAS Sbjct 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRAS 357 >gi|328885619|emb|CCA58858.1| Methylmalonate-semialdehyde dehydrogenase [Streptomyces venezuelae ATCC 10712] Length=499 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 363/509 (72%), Positives = 415/509 (82%), Gaps = 11/509 (2%) Query 1 MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA 60 M +++HFI G+ TAG S ADV+DPNTG +QA+VP+AG++D +AA+A A AQ+ W Sbjct 1 MVRELTHFIGGKHTAGTSGLFADVYDPNTGAVQARVPLAGRADTEAAIADAETAQQEWGR 60 Query 61 WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL 120 WNPQRRARVL+RF++LV D LA LLS EHGKT+ADA GD+QRG+EV+EF GIPHLL Sbjct 61 WNPQRRARVLLRFLQLVEGERDSLARLLSSEHGKTVADAHGDLQRGLEVVEFAAGIPHLL 120 Query 121 KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP 180 KGE+T+ AG GIDV+SLR PLGVVAGITPFNFPAMIPLWKA PALACGNAF+LKPSERDP Sbjct 121 KGEFTDNAGTGIDVHSLRSPLGVVAGITPFNFPAMIPLWKAAPALACGNAFILKPSERDP 180 Query 181 SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA 240 SVP+RLAELF+EAGLP GV VV+G KEAVD +L P ++A+GFVGS+ IA +IYA AAA Sbjct 181 SVPLRLAELFLEAGLPPGVLNVVNGGKEAVDTLLEDPRVQALGFVGSTPIAAHIYATAAA 240 Query 241 TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR 300 GKRAQCFGGAKNHMIVMPDADLDQA +ALIGAGYGSAGERCMAISVAVPVG++TA+ L Sbjct 241 HGKRAQCFGGAKNHMIVMPDADLDQAAEALIGAGYGSAGERCMAISVAVPVGEETADALV 300 Query 301 ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL 360 A+L ERI +LR+G S DP AD+GPLV+ AL RV YIG GV GAELVVDGR Sbjct 301 AKLKERIASLRIGTSDDPDADFGPLVSRDALDRVNRYIGIGVDEGAELVVDGRG------ 354 Query 361 TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE 420 F LP E GFF G +LFD V M IY +EIFGPVLC+ RA DYEEALRLPSEH Sbjct 355 -FTLP----GHENGFFAGASLFDRVTPAMRIYQEEIFGPVLCVARAADYEEALRLPSEHP 409 Query 421 YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA 480 +GNGVAIFTRDGD ARDF RV GMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGP + Sbjct 410 FGNGVAIFTRDGDTARDFTRRVNTGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPDS 469 Query 481 IQFYTKVKTVTSRWPSGIKDGAEFVIPTM 509 I+FYT+ KTVTSRWPSG+K+GA F +PTM Sbjct 470 IRFYTRTKTVTSRWPSGVKEGASFTMPTM 498 Lambda K H 0.320 0.138 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1107811580136 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40