BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0764c Length=451 Score E Sequences producing significant alignments: (Bits) Value gi|15607904|ref|NP_215278.1| cytochrome P450 sterol 14-alpha dem... 930 0.0 gi|13400014|pdb|1EA1|A Chain A, Cytochrome P450 14 Alpha-Sterol ... 929 0.0 gi|56967010|pdb|1X8V|A Chain A, Estriol-Bound And Ligand-Free St... 922 0.0 gi|221046480|pdb|2W0A|A Chain A, Cyp51 Of M. Tuberculosis Bound ... 920 0.0 gi|51247801|pdb|1U13|A Chain A, Crystal Structure Analysis Of Th... 919 0.0 gi|340625783|ref|YP_004744235.1| cytochrome P450 51 CYP51 [Mycob... 904 0.0 gi|298524254|ref|ZP_07011663.1| cytochrome p450 51 cyp51 [Mycoba... 903 0.0 gi|240171678|ref|ZP_04750337.1| cytochrome P450 51B1 Cyp51B1 [My... 785 0.0 gi|169628307|ref|YP_001701956.1| cytochrome P450 [Mycobacterium ... 768 0.0 gi|145222188|ref|YP_001132866.1| cytochrome P450 [Mycobacterium ... 751 0.0 gi|315442627|ref|YP_004075506.1| cytochrome P450 [Mycobacterium ... 751 0.0 gi|333992244|ref|YP_004524858.1| cytochrome P450 [Mycobacterium ... 746 0.0 gi|183984900|ref|YP_001853191.1| cytochrome P450 51B1 Cyp51B1 [M... 743 0.0 gi|193248877|dbj|BAG50429.1| cytochrome P450 [Mycobacterium chlo... 741 0.0 gi|118616315|ref|YP_904647.1| cytochrome P450 51B1 Cyp51B1 [Myco... 735 0.0 gi|108801545|ref|YP_641742.1| cytochrome P450 [Mycobacterium sp.... 735 0.0 gi|118467111|ref|YP_879984.1| cytochrome P450 51 [Mycobacterium ... 734 0.0 gi|41406696|ref|NP_959532.1| hypothetical protein MAP0598c [Myco... 734 0.0 gi|126437530|ref|YP_001073221.1| cytochrome P450 [Mycobacterium ... 733 0.0 gi|120406109|ref|YP_955938.1| cytochrome P450 [Mycobacterium van... 731 0.0 gi|342862194|ref|ZP_08718836.1| cytochrome P450 51 [Mycobacteriu... 729 0.0 gi|296166490|ref|ZP_06848921.1| cytochrome P450 51 [Mycobacteriu... 728 0.0 gi|254818459|ref|ZP_05223460.1| cytochrome P450 51 [Mycobacteriu... 727 0.0 gi|118473009|ref|YP_890090.1| cytochrome P450 [Mycobacterium sme... 724 0.0 gi|111021643|ref|YP_704615.1| cytochrome P450 [Rhodococcus josti... 722 0.0 gi|193248879|dbj|BAG50430.1| cytochrome P450 [Mycobacterium dier... 721 0.0 gi|254818478|ref|ZP_05223479.1| cytochrome P450 51 [Mycobacteriu... 719 0.0 gi|226364180|ref|YP_002781962.1| cytochrome P450 51 [Rhodococcus... 716 0.0 gi|54024558|ref|YP_118800.1| cytochrome P450 monooxygenase [Noca... 706 0.0 gi|226306864|ref|YP_002766824.1| cytochrome P450 51 [Rhodococcus... 703 0.0 gi|229492759|ref|ZP_04386560.1| cytochrome p450 51 [Rhodococcus ... 700 0.0 gi|312138815|ref|YP_004006151.1| cytochrome p450 monooxygenase [... 687 0.0 gi|325676485|ref|ZP_08156163.1| cytochrome P450 51 [Rhodococcus ... 686 0.0 gi|319950412|ref|ZP_08024328.1| cytochrome P450 CYP51 [Dietzia c... 652 0.0 gi|326384238|ref|ZP_08205920.1| cytochrome P450 [Gordonia neofel... 625 4e-177 gi|262203706|ref|YP_003274914.1| cytochrome P450 [Gordonia bronc... 615 6e-174 gi|343927847|ref|ZP_08767315.1| cytochrome P450 51 [Gordonia alk... 608 5e-172 gi|326331689|ref|ZP_08197977.1| cytochrome P450 51 [Nocardioidac... 583 2e-164 gi|53803178|ref|YP_115112.1| cytochrome P450 51 [Methylococcus c... 415 7e-114 gi|304310752|ref|YP_003810350.1| Cytochrome P450 51 [gamma prote... 413 4e-113 gi|149917920|ref|ZP_01906414.1| cytochrome P450 51 [Plesiocystis... 366 5e-99 gi|297844012|ref|XP_002889887.1| CYP51G1 [Arabidopsis lyrata sub... 297 2e-78 gi|224072463|ref|XP_002303744.1| cytochrome P450 probable obtusi... 295 9e-78 gi|224057852|ref|XP_002299356.1| cytochrome P450 obtusifoliol 14... 295 2e-77 gi|15221075|ref|NP_172633.1| cytochrome P450, family 51 (sterol ... 295 2e-77 gi|224000301|ref|XP_002289823.1| obtusifoliol 14-alpha demethyla... 293 5e-77 gi|299735181|gb|ADJ37071.1| obtusifoliol 14alpha-demethylase [So... 291 2e-76 gi|47156870|gb|AAT12274.1| obtusifoliol 14alpha-demethylase [Sol... 291 2e-76 gi|189503705|gb|ACE06982.1| obtusifoliol-14alpha-demethylase [Go... 286 3e-75 gi|255543234|ref|XP_002512680.1| cytochrome P450, putative [Rici... 285 9e-75 >gi|15607904|ref|NP_215278.1| cytochrome P450 sterol 14-alpha demethylase [Mycobacterium tuberculosis H37Rv] gi|15840179|ref|NP_335216.1| P450 heme-thiolate protein [Mycobacterium tuberculosis CDC1551] gi|31791952|ref|NP_854445.1| cytochrome P450 sterol 14-alpha demethylase [Mycobacterium bovis AF2122/97] 78 more sequence titles Length=451 Score = 930 bits (2404), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/451 (100%), Positives = 451/451 (100%), Gaps = 0/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR Sbjct 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP Sbjct 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV Sbjct 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 >gi|13400014|pdb|1EA1|A Chain A, Cytochrome P450 14 Alpha-Sterol Demethylase (Cyp51) From Mycobacterium Tuberculosis In Complex With Fluconazole gi|13400015|pdb|1E9X|A Chain A, Cytochrome P450 14 Alpha-Sterol Demethylase (Cyp51) From Mycobacterium Tuberculosis In Complex With 4- Phenylimidazole gi|37926409|pdb|1H5Z|A Chain A, Cytochrome P450 14 Alpha-Sterol Demethylase (Cyp51) From Mycobacterium Tuberculosis In Ferric Low-Spin State Length=455 Score = 929 bits (2402), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/451 (100%), Positives = 451/451 (100%), Gaps = 0/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR Sbjct 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP Sbjct 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV Sbjct 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 >gi|56967010|pdb|1X8V|A Chain A, Estriol-Bound And Ligand-Free Structures Of Sterol 14alpha- Demethylase (Cyp51) gi|122919635|pdb|2BZ9|A Chain A, Ligand-Free Structure Of Sterol 14alpha-Demethylase From Mycobacterium Tuberculosis In P2(1) Space Group gi|122919636|pdb|2BZ9|B Chain B, Ligand-Free Structure Of Sterol 14alpha-Demethylase From Mycobacterium Tuberculosis In P2(1) Space Group gi|151566462|pdb|2CI0|A Chain A, High Throughput Screening And X-Ray Crystallography Assisted Evaluation Of Small Molecule Scaffolds For Cyp51 Inhibitors gi|151566463|pdb|2CIB|A Chain A, High Throughput Screening And X-Ray Crystallography Assisted Evaluation Of Small Molecule Scaffolds For Cyp51 Inhibitors gi|170785069|pdb|2VKU|A Chain A, 4,4'-Dihydroxybenzophenone Mimics Sterol Substrate In The Binding Site Of Sterol 14alpha-Demethylase (Cyp51) In The X-Ray Structure Of The Complex gi|221046479|pdb|2W09|A Chain A, Cyp51 Of M. Tuberculosis Bound To An Inhibitor Cis-4- Methyl-N-[(1s)-3-(Methylsulfanyl)-1-(Pyridin-4- Ylcarbamoyl)propyl]cyclohexanecarboxamide gi|221046481|pdb|2W0B|A Chain A, Cyp51 Of M. Tuberculosis Bound To An Inhibitor 3-{[(4- Methylphenyl)sulfonyl]amino}propyl Pyridin-4-Ylcarbamate Length=455 Score = 922 bits (2384), Expect = 0.0, Method: Compositional matrix adjust. Identities = 449/451 (99%), Positives = 449/451 (99%), Gaps = 0/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDE GDVGTFQLAGKQVVLLSGSHANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR Sbjct 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP Sbjct 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPA VRYRRRTGV Sbjct 421 QPPESYRNDHSKMVVQLAQPAAVRYRRRTGV 451 >gi|221046480|pdb|2W0A|A Chain A, Cyp51 Of M. Tuberculosis Bound To An Inhibitor N-[(1s)-2-Methyl-1-(Pyridin-4-Ylcarbamoyl)propyl] Cyclohexanecarboxamide Length=455 Score = 920 bits (2378), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/451 (99%), Positives = 448/451 (99%), Gaps = 0/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDE GDVGTFQLAGKQVVLLSGSHANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFMTPIFGE VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMTPIFGEAVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR Sbjct 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP Sbjct 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPA VRYRRRTGV Sbjct 421 QPPESYRNDHSKMVVQLAQPAAVRYRRRTGV 451 >gi|51247801|pdb|1U13|A Chain A, Crystal Structure Analysis Of The C37lC151TC442A-Triple Mutant Of Cyp51 From Mycobacterium Tuberculosis Length=455 Score = 919 bits (2376), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/451 (99%), Positives = 448/451 (99%), Gaps = 0/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDE GDVGTFQLAGKQVVLLSGSHANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSA LIGKKFRDQLDGRFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSATLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR Sbjct 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP Sbjct 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPA VRYRRRTGV Sbjct 421 QPPESYRNDHSKMVVQLAQPAAVRYRRRTGV 451 >gi|340625783|ref|YP_004744235.1| cytochrome P450 51 CYP51 [Mycobacterium canettii CIPT 140010059] gi|340003973|emb|CCC43108.1| cytochrome P450 51 CYP51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) [Mycobacterium canettii CIPT 140010059] Length=453 Score = 904 bits (2335), Expect = 0.0, Method: Compositional matrix adjust. Identities = 439/451 (98%), Positives = 443/451 (99%), Gaps = 0/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSG+ ANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGAQANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFM PIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMKPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLD RFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDRRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEAR GLVALVADIMNGRIANPPTDKSDRDMLDVLIAVK ETGTPR Sbjct 181 YVDPYLPIESFRRRDEARKGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKDETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVI+ELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVINELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+LENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP Sbjct 301 LRQIPRLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP DFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 361 DPDDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPACVRYR R+G Sbjct 421 QPPESYRNDHSKMVVQLAQPACVRYRLRSGT 451 >gi|298524254|ref|ZP_07011663.1| cytochrome p450 51 cyp51 [Mycobacterium tuberculosis 94_M4241A] gi|298494048|gb|EFI29342.1| cytochrome p450 51 cyp51 [Mycobacterium tuberculosis 94_M4241A] Length=450 Score = 903 bits (2334), Expect = 0.0, Method: Compositional matrix adjust. Identities = 442/451 (99%), Positives = 442/451 (99%), Gaps = 1/451 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE Sbjct 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ Sbjct 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA Sbjct 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR Sbjct 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA Sbjct 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHE V SNRIPEDFP Sbjct 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEPGGVVPR-YFSNRIPEDFP 359 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA Sbjct 360 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 419 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV Sbjct 420 QPPESYRNDHSKMVVQLAQPACVRYRRRTGV 450 >gi|240171678|ref|ZP_04750337.1| cytochrome P450 51B1 Cyp51B1 [Mycobacterium kansasii ATCC 12478] Length=451 Score = 785 bits (2028), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/448 (84%), Positives = 409/448 (92%), Gaps = 0/448 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG DEHGHLEEFRTDPIGLMQRVRDECGDVG FQLA K VVLLSG+ ANE Sbjct 1 MTTAIVPRVSGGQDEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLADKHVVLLSGAKANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D++LDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGE MKGHAATIE + Sbjct 61 FFFRSSDEELDQAQAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHAATIERE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V RMI +W + GEIDLLDFFAELTIYTS++CLIG KFR+QLD RFA YHELERGTDPL Sbjct 121 VHRMIENWCDEGEIDLLDFFAELTIYTSTSCLIGTKFRNQLDSRFAHFYHELERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPI+SFRRRDEAR GLVALV +IM+ RIANPP DK DRDMLDVL++++ E G PR Sbjct 181 YVDPYLPIDSFRRRDEARKGLVALVQEIMHQRIANPPIDKRDRDMLDVLVSIRDEAGHPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADEITGMFIS+MFAGHHTSSGT++WTLIEL+RH DAYA VI ELDELY DG+ VSFHA Sbjct 241 FSADEITGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAEVIAELDELYADGQPVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP LENVLKETLRLHPPLIILMRVAKGEFEV+G+ IHEG+LVAASPAISNRIPEDFP Sbjct 301 LRQIPHLENVLKETLRLHPPLIILMRVAKGEFEVEGYPIHEGELVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP DFVP RY++PRQEDL+NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDDFVPQRYDEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRR 448 QPP+SYRNDHSKMVVQLA+PA VRYRRR Sbjct 421 QPPDSYRNDHSKMVVQLARPATVRYRRR 448 >gi|169628307|ref|YP_001701956.1| cytochrome P450 [Mycobacterium abscessus ATCC 19977] gi|169240274|emb|CAM61302.1| Probable cytochrome P450 [Mycobacterium abscessus] Length=453 Score = 768 bits (1983), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/453 (81%), Positives = 407/453 (90%), Gaps = 3/453 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG D++GHLEEFRTDPI LM+R+R ECG+VGTFQLA KQVV LSG+ ANE Sbjct 1 MTTPTVPRVSGGEDQYGHLEEFRTDPIALMKRIRAECGNVGTFQLADKQVVFLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D+DLDQA+AYPFMTPIFG+GVVFDA PERRKEMLHNAALRGEQMKGHAATIE++ Sbjct 61 FFFRSSDEDLDQAEAYPFMTPIFGKGVVFDADPERRKEMLHNAALRGEQMKGHAATIENE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VR+MI+ WGE+GE+DLLDFFAELTIYTSSACLIGKKFRD+LDGRFA LYH+LE+GTDPL Sbjct 121 VRQMISRWGESGEVDLLDFFAELTIYTSSACLIGKKFRDELDGRFAHLYHQLEQGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRI---ANPPTDKSDRDMLDVLIAVKAETG 237 YVDPYL IESFR+RDEAR GLVALV +I+NGR+ A+ PTDKS RDMLDVLI +K E G Sbjct 181 YVDPYLEIESFRQRDEARTGLVALVQEIINGRVQRSADSPTDKSQRDMLDVLIMIKDEHG 240 Query 238 TPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVS 297 PRF+ADEITGMFISMMFAGHHTSSGTASW LIEL+RH D + VIDELDELY DG VS Sbjct 241 NPRFTADEITGMFISMMFAGHHTSSGTASWVLIELLRHPDIQSQVIDELDELYADGSEVS 300 Query 298 FHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPE 357 FHALRQIP+LENVLKETLRLHPPLIILMRVAKGEFEV G IH+GD+VAASPA+SNRI E Sbjct 301 FHALRQIPKLENVLKETLRLHPPLIILMRVAKGEFEVGGFPIHDGDMVAASPAVSNRIAE 360 Query 358 DFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF 417 DFP+P FVP RYE+PRQED++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEF Sbjct 361 DFPNPDGFVPDRYEKPRQEDIVNRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF 420 Query 418 EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG 450 EMAQP +SY NDHSKMVVQLAQPA VRYR+R+ Sbjct 421 EMAQPADSYHNDHSKMVVQLAQPAKVRYRKRSA 453 >gi|145222188|ref|YP_001132866.1| cytochrome P450 [Mycobacterium gilvum PYR-GCK] gi|145214674|gb|ABP44078.1| cytochrome P450 [Mycobacterium gilvum PYR-GCK] Length=452 Score = 751 bits (1939), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/450 (80%), Positives = 401/450 (90%), Gaps = 1/450 (0%) Query 1 MSAVALPRVSGGHD-EHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHAN 59 M+ +PRVSGG D EHGHLEEFRTDPIGLM+R+R+ECGDVG FQLA KQVV+LSG+ AN Sbjct 1 MTTAIVPRVSGGEDDEHGHLEEFRTDPIGLMKRIREECGDVGWFQLADKQVVMLSGAEAN 60 Query 60 EFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIED 119 EFFFR+ D +L+QA+AYPFMTPIFGEGVVFDA PERR EMLHN ALRGEQMKGHAATIE+ Sbjct 61 EFFFRSTDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIEN 120 Query 120 QVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPL 179 +VRRMI +WGE GEI+LLDFF+ELTIYTS+ACLIG KFR+QLD RFA+ YH LERGTDPL Sbjct 121 EVRRMIENWGEQGEIELLDFFSELTIYTSTACLIGLKFRNQLDSRFAEYYHLLERGTDPL 180 Query 180 AYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTP 239 YVDPYLPIESFR RDEAR LV LV ++MNGRIANPPTDKSDRD+LDVL+++K E G P Sbjct 181 CYVDPYLPIESFRIRDEARASLVELVQEVMNGRIANPPTDKSDRDLLDVLVSIKDEDGNP 240 Query 240 RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFH 299 RFSA+E+TGMFIS+MFAGHHTSSGT+SWTLIEL+RH + YA V ELD+LY DG+ VSFH Sbjct 241 RFSANEVTGMFISLMFAGHHTSSGTSSWTLIELLRHPEYYAQVQQELDDLYADGQEVSFH 300 Query 300 ALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDF 359 ALRQIP+++N LKETLRLHPPLIILMRVA+ EFEV G+ IH+G +VAASPAISNRIPEDF Sbjct 301 ALRQIPKIDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDF 360 Query 360 PDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEM 419 P P F P RYE+PRQEDL+NRWTWIPFGAG+HRCVGAAFA MQIKAIFSVLLREYEFEM Sbjct 361 PYPDAFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM 420 Query 420 AQPPESYRNDHSKMVVQLAQPACVRYRRRT 449 AQP ESY+NDHSKMVVQLA+PA VRYRRR Sbjct 421 AQPAESYQNDHSKMVVQLARPAKVRYRRRV 450 >gi|315442627|ref|YP_004075506.1| cytochrome P450 [Mycobacterium sp. Spyr1] gi|315260930|gb|ADT97671.1| cytochrome P450 [Mycobacterium sp. Spyr1] Length=452 Score = 751 bits (1938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/450 (80%), Positives = 401/450 (90%), Gaps = 1/450 (0%) Query 1 MSAVALPRVSGGHD-EHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHAN 59 M+ +PRVSGG D EHGHLEEFRTDPIGLM+R+R+ECGDVG FQLA KQVV+LSG+ AN Sbjct 1 MTTAIVPRVSGGEDDEHGHLEEFRTDPIGLMKRIREECGDVGWFQLADKQVVMLSGAEAN 60 Query 60 EFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIED 119 EFFFR+ D +L+QA+AYPFMTPIFGEGVVFDA PERR EMLHN ALRGEQMKGHAATIE+ Sbjct 61 EFFFRSTDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIEN 120 Query 120 QVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPL 179 +VRRMI +WGE GEI+LLDFF+ELTIYTS+ACLIG KFR+QLD RFA+ YH LERGTDPL Sbjct 121 EVRRMIENWGEQGEIELLDFFSELTIYTSTACLIGLKFRNQLDSRFAEYYHLLERGTDPL 180 Query 180 AYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTP 239 YVDPYLPIESFR RDEAR LV LV ++MNGRIANPPTDKSDRD+LDVL+++K E G P Sbjct 181 CYVDPYLPIESFRIRDEARANLVELVQEVMNGRIANPPTDKSDRDLLDVLVSIKDEDGNP 240 Query 240 RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFH 299 RFSA+E+TGMFIS+MFAGHHTSSGT+SWTLIEL+RH + YA V ELD+LY DG+ VSFH Sbjct 241 RFSANEVTGMFISLMFAGHHTSSGTSSWTLIELLRHPEYYAQVQQELDDLYADGQEVSFH 300 Query 300 ALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDF 359 ALRQIP+++N LKETLRLHPPLIILMRVA+ EFEV G+ IH+G +VAASPAISNRIPEDF Sbjct 301 ALRQIPKIDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDF 360 Query 360 PDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEM 419 P P F P RYE+PRQEDL+NRWTWIPFGAG+HRCVGAAFA MQIKAIFSVLLREYEFEM Sbjct 361 PYPDAFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM 420 Query 420 AQPPESYRNDHSKMVVQLAQPACVRYRRRT 449 AQP ESY+NDHSKMVVQLA+PA VRYRRR Sbjct 421 AQPAESYQNDHSKMVVQLARPAKVRYRRRV 450 >gi|333992244|ref|YP_004524858.1| cytochrome P450 [Mycobacterium sp. JDM601] gi|333488212|gb|AEF37604.1| cytochrome P450 51B1 Cyp51B1 [Mycobacterium sp. JDM601] Length=451 Score = 746 bits (1926), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/444 (80%), Positives = 399/444 (90%), Gaps = 0/444 (0%) Query 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 +PRVSGG EHGHLEEFRTDPIGLMQRVRDECGDVG F LAG++VVLL+G+ ANEFFFR+ Sbjct 7 VPRVSGGEAEHGHLEEFRTDPIGLMQRVRDECGDVGWFDLAGRKVVLLTGAEANEFFFRS 66 Query 66 GDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMI 125 GDD+LDQA AYPFMTPIFG GVVFDA PERR EMLHN ALRG+ MK HA+TIE +VR+MI Sbjct 67 GDDELDQAAAYPFMTPIFGNGVVFDAPPERRAEMLHNTALRGDHMKRHASTIEHEVRKMI 126 Query 126 ADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPY 185 WGE+GEIDLL+FFAELTIYTS+ACLIG+KFR++LD RFA+LY+ELERGTDPL YVDPY Sbjct 127 EGWGESGEIDLLEFFAELTIYTSTACLIGQKFREELDHRFAELYYELERGTDPLCYVDPY 186 Query 186 LPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADE 245 LPIESF+RRD AR LV LV IM+GRIANP TDK RDM+DV++++ E+G PRFSADE Sbjct 187 LPIESFQRRDAARVKLVELVQGIMDGRIANPETDKRRRDMIDVMVSIPDESGNPRFSADE 246 Query 246 ITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIP 305 ITG+ IS+MFAGHHTSSGT++WTLIEL+RH +A AAVI ELDELY DG VSFHALRQIP Sbjct 247 ITGIIISIMFAGHHTSSGTSAWTLIELLRHPEALAAVISELDELYADGGEVSFHALRQIP 306 Query 306 QLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDF 365 LENVLKETLRLHPPLIILMR+AKGEFEV G+ IHEGD+VAASPA+SNRIPE FP+P++F Sbjct 307 NLENVLKETLRLHPPLIILMRMAKGEFEVCGYPIHEGDMVAASPAVSNRIPESFPEPNEF 366 Query 366 VPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPES 425 VP RY +PR+ED+L RWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEM+QPPE+ Sbjct 367 VPERYNEPREEDVLQRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMSQPPET 426 Query 426 YRNDHSKMVVQLAQPACVRYRRRT 449 YRNDHSKMVVQLA+PA VRYRRRT Sbjct 427 YRNDHSKMVVQLARPAKVRYRRRT 450 >gi|183984900|ref|YP_001853191.1| cytochrome P450 51B1 Cyp51B1 [Mycobacterium marinum M] gi|183178226|gb|ACC43336.1| cytochrome P450 51B1 Cyp51B1 [Mycobacterium marinum M] Length=456 Score = 743 bits (1917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 362/438 (83%), Positives = 400/438 (92%), Gaps = 0/438 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLMQRVRDECGDVG FQLA K VVLLSG+ ANE Sbjct 1 MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLANKHVVLLSGAKANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D++LDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGE MKGHA TIE + Sbjct 61 FFFRSSDEELDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHATTIERE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V RMI +WG+ GEIDLL+FFAELTIYTS++CLIG KFR+QLD RFA YHELERGTDPL Sbjct 121 VHRMIENWGQEGEIDLLEFFAELTIYTSTSCLIGTKFRNQLDSRFAHFYHELERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEAR GLVALV DIM+ R+ANPPTDK DRDMLDVL+++ E G PR Sbjct 181 YVDPYLPIESFRRRDEARKGLVALVQDIMHQRVANPPTDKRDRDMLDVLVSITDEQGNPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 F ADE+TGMFIS+MFAGHHTSSGT++WTLIEL+RH DAYAAVIDELDELY DG+ VSFHA Sbjct 241 FCADEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAAVIDELDELYADGQPVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+LENVLKETLRLHPPLIILMRVAKGEF+V+G+ IHEG+LVAASPAISNRI EDFP Sbjct 301 LRQIPRLENVLKETLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP +FVP RY++PRQEDL+NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDEFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLA 438 QP +SYRNDHSKMVVQLA Sbjct 421 QPADSYRNDHSKMVVQLA 438 >gi|193248877|dbj|BAG50429.1| cytochrome P450 [Mycobacterium chlorophenolicum] Length=449 Score = 741 bits (1912), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/448 (81%), Positives = 403/448 (90%), Gaps = 0/448 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLM R+R+ECGDVG FQLA KQVV+LSG+ ANE Sbjct 1 MTTATVPRVSGGEEEHGHLEEFRTDPIGLMTRIREECGDVGWFQLADKQVVMLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ DD+L+QA+AYPFMTPIFGEGVVFDA PERRKEMLHN+ALRGEQMKGHA TIE++ Sbjct 61 FFFRSSDDELNQAEAYPFMTPIFGEGVVFDADPERRKEMLHNSALRGEQMKGHATTIENE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 VRRMI +WG+AGEIDLL+FFAELTIYTS+ACLIG KFR+QLD RFA YH LERGTDPL Sbjct 121 VRRMIENWGDAGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFR RDEAR GLV LV ++MNGRIANPP DK+DRDMLDVL+++K E G PR Sbjct 181 YVDPYLPIESFRIRDEARAGLVELVQEVMNGRIANPPKDKADRDMLDVLVSIKDEEGNPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSA+E+TGMFIS+MFAGHHTSSGT+SWTLIEL+RH + YA V ELDELY DG+ VSFHA Sbjct 241 FSANEVTGMFISLMFAGHHTSSGTSSWTLIELLRHPEFYAQVQQELDELYADGQEVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+L+N LKETLRLHPPLIILMRVA+ +FEV G IH+G +VAASPAISNRIPEDFP Sbjct 301 LRQIPKLDNALKETLRLHPPLIILMRVAQDDFEVAGLPIHKGQMVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP F P RYE+PRQEDL+NRWTWIPFGAG+HRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDAFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRR 448 QPPESYRNDHSKMVVQLA+PA VRYRRR Sbjct 421 QPPESYRNDHSKMVVQLARPAKVRYRRR 448 >gi|118616315|ref|YP_904647.1| cytochrome P450 51B1 Cyp51B1 [Mycobacterium ulcerans Agy99] gi|118568425|gb|ABL03176.1| cytochrome P450 51B1 Cyp51B1 [Mycobacterium ulcerans Agy99] Length=456 Score = 735 bits (1898), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/438 (82%), Positives = 397/438 (91%), Gaps = 0/438 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLMQRVRDECGDVG FQLA K VVLLSG+ ANE Sbjct 1 MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLANKHVVLLSGAKANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D++LDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGE MKGHA TIE + Sbjct 61 FFFRSSDEELDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHATTIERE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V RMI +WG+ GEIDLL+FFAELT YTS++CLIG KFR+QLD RFA HELERGTDPL Sbjct 121 VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCHELERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESFRRRDEAR GLVALV DIM+ R+ANPPTDK DRDMLDVL+++ E G PR Sbjct 181 YVDPYLPIESFRRRDEARKGLVALVQDIMHQRVANPPTDKRDRDMLDVLVSITDEQGNPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 F DE+TGMFIS+MFAGHHTSSGT++WTLIEL+RH DAYAAVIDELDELY DG+ VSFHA Sbjct 241 FCTDEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAAVIDELDELYADGQLVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+LENVLKETLRLHPPLIILMRVAKGEF+V+G+ IHEG+LVAASPAISNRI EDFP Sbjct 301 LRQIPRLENVLKETLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP +FVP RY++PRQEDL+NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDEFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLA 438 QP +SYRNDHSKMVVQLA Sbjct 421 QPADSYRNDHSKMVVQLA 438 >gi|108801545|ref|YP_641742.1| cytochrome P450 [Mycobacterium sp. MCS] gi|119870699|ref|YP_940651.1| cytochrome P450 [Mycobacterium sp. KMS] gi|108771964|gb|ABG10686.1| cytochrome P450 [Mycobacterium sp. MCS] gi|119696788|gb|ABL93861.1| cytochrome P450 [Mycobacterium sp. KMS] Length=451 Score = 735 bits (1897), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/449 (80%), Positives = 401/449 (90%), Gaps = 0/449 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLM+RVRDECGDVG FQL K V+LLSG+ ANE Sbjct 1 MTTAVVPRVSGGEEEHGHLEEFRTDPIGLMKRVRDECGDVGWFQLVDKHVILLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D+DLDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGE MK HAATIE + Sbjct 61 FFFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKSHAATIEGE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V++MIA WGE GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YHELERGTDPL Sbjct 121 VKKMIAGWGEEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHELERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESF+RRDEAR LVALV +IMN R+A+PP DK+DRDMLDVL+++K E G PR Sbjct 181 YVDPYLPIESFQRRDEARVKLVALVQEIMNQRVADPPKDKADRDMLDVLVSIKDEEGNPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADE+TGMFIS+MFAGHHTSSGT+SWTLIEL+RH + YAAV ELDELY DG+ VSFHA Sbjct 241 FSADEVTGMFISLMFAGHHTSSGTSSWTLIELIRHPEVYAAVQQELDELYADGQEVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP L+NV+KETLRLHPPLIILMRVA+GEFEV G IH+GD VAASPAISNRIPEDFP Sbjct 301 LRQIPLLDNVVKETLRLHPPLIILMRVAQGEFEVAGFPIHKGDFVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP F P RY++P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDAFKPDRYDKPEQADVVNRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRT 449 QPPE+YRNDHSKMVVQL +PA VRYRRR Sbjct 421 QPPETYRNDHSKMVVQLERPAKVRYRRRV 449 >gi|118467111|ref|YP_879984.1| cytochrome P450 51 [Mycobacterium avium 104] gi|254773647|ref|ZP_05215163.1| cytochrome P450 51 [Mycobacterium avium subsp. avium ATCC 25291] gi|76057120|gb|ABA39231.1| cytochrome P450 lanosterol 14-alpha demethylase [Mycobacterium avium subsp. avium ATCC 25291] gi|118168398|gb|ABK69295.1| cytochrome P450 51 [Mycobacterium avium 104] Length=451 Score = 734 bits (1896), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/449 (80%), Positives = 404/449 (90%), Gaps = 0/449 (0%) Query 2 SAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEF 61 ++ +PRVSGG +EHGHLEEFRTDPIGLMQRVRDECGDVG FQL K V+LLSG+ ANEF Sbjct 3 TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 62 Query 62 FFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQV 121 FFR+ D+DLDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGEQMKGHA+TIE +V Sbjct 63 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 122 Query 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAY 181 ++MIADWG+ GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YH+LERGTDPL Y Sbjct 123 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 182 Query 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 VDPYLPIESF+RRDEAR LVALV +IM+ R+ANPP DK+DRDMLDVL+++K E G PRF Sbjct 183 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 242 Query 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 SADEITGMFIS+MFAGHHTSSGT++WTLIEL+RH D YA V+ EL+ELY DG+ VSFHAL Sbjct 243 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 302 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 R IP+L+NV+KETLRLHPPLIILMRVAKGEFEV+G IHEGD VAASPAISNRIPEDFPD Sbjct 303 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 362 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 P F P RY +P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREY+FEMAQ Sbjct 363 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 422 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRRTG 450 P +SYRNDHSKMVVQLA+PA VRYR+R Sbjct 423 PADSYRNDHSKMVVQLARPAKVRYRKRNA 451 >gi|41406696|ref|NP_959532.1| hypothetical protein MAP0598c [Mycobacterium avium subsp. paratuberculosis K-10] gi|41395046|gb|AAS02915.1| hypothetical protein MAP_0598c [Mycobacterium avium subsp. paratuberculosis K-10] gi|336458360|gb|EGO37338.1| cytochrome P450 [Mycobacterium avium subsp. paratuberculosis S397] Length=451 Score = 734 bits (1895), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/449 (80%), Positives = 404/449 (90%), Gaps = 0/449 (0%) Query 2 SAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEF 61 ++ +PR+SGG +EHGHLEEFRTDPIGLMQRVRDECGDVG FQL K V+LLSG+ ANEF Sbjct 3 TSTVVPRISGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 62 Query 62 FFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQV 121 FFR+ D+DLDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGEQMKGHA+TIE +V Sbjct 63 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 122 Query 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAY 181 ++MIADWG+ GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YH+LERGTDPL Y Sbjct 123 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 182 Query 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 VDPYLPIESF+RRDEAR LVALV +IM+ R+ANPP DK+DRDMLDVL+++K E G PRF Sbjct 183 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 242 Query 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 SADEITGMFIS+MFAGHHTSSGT++WTLIEL+RH D YA V+ EL+ELY DG+ VSFHAL Sbjct 243 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 302 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 R IP+L+NV+KETLRLHPPLIILMRVAKGEFEV+G IHEGD VAASPAISNRIPEDFPD Sbjct 303 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 362 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 P F P RY +P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREY+FEMAQ Sbjct 363 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 422 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRRTG 450 P +SYRNDHSKMVVQLA+PA VRYR+R Sbjct 423 PADSYRNDHSKMVVQLARPAKVRYRKRNA 451 >gi|126437530|ref|YP_001073221.1| cytochrome P450 [Mycobacterium sp. JLS] gi|126237330|gb|ABO00731.1| cytochrome P450 [Mycobacterium sp. JLS] Length=451 Score = 733 bits (1893), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/449 (80%), Positives = 401/449 (90%), Gaps = 0/449 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLM+RVRDECGDVG FQL K V+LLSG+ ANE Sbjct 1 MTTAVVPRVSGGEEEHGHLEEFRTDPIGLMKRVRDECGDVGWFQLVDKHVILLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D+DLDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGE MK HAATIE + Sbjct 61 FFFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKSHAATIEGE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V++MIA WG+ GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YHELERGTDPL Sbjct 121 VKKMIAGWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHELERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPIESF+RRDEAR LVALV +IMN R+A+PP DK+DRDMLDVL+++K E G PR Sbjct 181 YVDPYLPIESFQRRDEARVKLVALVQEIMNQRVADPPKDKADRDMLDVLVSIKDEEGNPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADE+TGMFIS+MFAGHHTSSGT+SWTLIEL+RH + YAAV ELDELY DG+ VSFHA Sbjct 241 FSADEVTGMFISLMFAGHHTSSGTSSWTLIELIRHPEVYAAVQQELDELYADGQEVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP L+NV+KETLRLHPPLIILMRVA+GEFEV G IH+GD VAASPAISNRIPEDFP Sbjct 301 LRQIPLLDNVVKETLRLHPPLIILMRVAQGEFEVAGFPIHKGDFVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP F P RY++P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDAFKPDRYDKPEQADVVNRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRT 449 QPPE+YRNDHSKMVVQL +PA VRYRRR Sbjct 421 QPPETYRNDHSKMVVQLERPAKVRYRRRV 449 >gi|120406109|ref|YP_955938.1| cytochrome P450 [Mycobacterium vanbaalenii PYR-1] gi|76363495|sp|Q5IZM4.1|CP51_MYCVP RecName: Full=Lanosterol 14-alpha demethylase; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51; AltName: Full=Cytochrome P450-14DM; AltName: Full=Cytochrome P450-LIA1; AltName: Full=Sterol 14-alpha demethylase gi|48237446|gb|AAT40578.1| putative cytochrome p450 [Mycobacterium vanbaalenii PYR-1] gi|119958927|gb|ABM15932.1| cytochrome P450 [Mycobacterium vanbaalenii PYR-1] Length=452 Score = 731 bits (1886), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/450 (80%), Positives = 401/450 (90%), Gaps = 1/450 (0%) Query 1 MSAVA-LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHAN 59 M+AV +PRVSGG +EHGHLEEFRTDPIGLM+RVR+ECGDVG FQLA KQV+LLSG+ AN Sbjct 1 MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEAN 60 Query 60 EFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIED 119 EFFFR+ D +L+QA+AYPFMTPIFGEGVVFDA PERR EMLHN ALRGE MKGHA TIE Sbjct 61 EFFFRSSDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEA 120 Query 120 QVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPL 179 +VR+MI WGE+GEIDLL+FFAELTIYTS+ACLIG KFR+QLD RFA YH LERGTDPL Sbjct 121 EVRKMIEGWGESGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPL 180 Query 180 AYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTP 239 YVDPYLPIESFR RDEAR GLV LV D+M+GRIANPP DKSDRDMLDVL+++K E G P Sbjct 181 CYVDPYLPIESFRIRDEARAGLVELVQDVMHGRIANPPKDKSDRDMLDVLVSIKDEDGNP 240 Query 240 RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFH 299 RF+A+EITGMFIS+MFAGHHTSSGT+SWTLIEL+RH + YA V ELD+LY DG+ VSFH Sbjct 241 RFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFYAKVQQELDDLYADGQEVSFH 300 Query 300 ALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDF 359 ALRQIP L+N LKETLRLHPPLIILMRVA+ EFEV G+ IH+G +VAASPAISNRIPEDF Sbjct 301 ALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDF 360 Query 360 PDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEM 419 P+P DF P RYE+PRQEDL+NRWTWIPFGAG+HRCVGAAFA MQIKAIFSVLLREYEFEM Sbjct 361 PNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM 420 Query 420 AQPPESYRNDHSKMVVQLAQPACVRYRRRT 449 AQPPESY+NDHSKMVVQLA+PA VRYRRR Sbjct 421 AQPPESYQNDHSKMVVQLARPAKVRYRRRV 450 >gi|342862194|ref|ZP_08718836.1| cytochrome P450 51 [Mycobacterium colombiense CECT 3035] gi|342130272|gb|EGT83592.1| cytochrome P450 51 [Mycobacterium colombiense CECT 3035] Length=451 Score = 729 bits (1882), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/448 (80%), Positives = 401/448 (90%), Gaps = 0/448 (0%) Query 2 SAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEF 61 ++ +PRVSGG +EHGHLEEFRTDPIGLM+RVRDECGDVG FQL K V+LLSG++ANEF Sbjct 3 TSTVVPRVSGGEEEHGHLEEFRTDPIGLMKRVRDECGDVGWFQLVDKHVILLSGANANEF 62 Query 62 FFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQV 121 FFR+ D+DLDQA AYPFM PIFG+GVVFDASPERRKEMLHN+ALRGEQMKGHAATIE QV Sbjct 63 FFRSADEDLDQAAAYPFMAPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHAATIEAQV 122 Query 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAY 181 + MIADWG+ GEI+LLDFF+ELTIYTS+ACLIG KFR+QLD RFA+ YHELERGTDPL Y Sbjct 123 QGMIADWGDEGEIELLDFFSELTIYTSTACLIGVKFRNQLDHRFAEYYHELERGTDPLCY 182 Query 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 VDPYLPIESFRRRDEAR LVALV +IMN R++NPP DKSDRDMLDVL+++K E G PRF Sbjct 183 VDPYLPIESFRRRDEARVKLVALVQEIMNQRVSNPPKDKSDRDMLDVLVSIKDEDGNPRF 242 Query 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 SADE+TGMFIS+MFAGHHTSSGT++WTLIEL+RH + YA V+ EL+ELY DG+ VSFHAL Sbjct 243 SADEVTGMFISLMFAGHHTSSGTSAWTLIELIRHPEVYAEVLAELEELYADGQEVSFHAL 302 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 R IP+L+NV+KETLRLHPPLIILMRVA+GEFEV+G IH GD VAASPAISNRIPEDFPD Sbjct 303 RSIPKLDNVVKETLRLHPPLIILMRVAQGEFEVEGFPIHAGDFVAASPAISNRIPEDFPD 362 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 P F P RY +P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMAQ Sbjct 363 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEFEMAQ 422 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRRT 449 P +SY NDHSKMVVQLA+PA VRYR+R+ Sbjct 423 PADSYHNDHSKMVVQLARPAKVRYRKRS 450 >gi|296166490|ref|ZP_06848921.1| cytochrome P450 51 [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295898102|gb|EFG77677.1| cytochrome P450 51 [Mycobacterium parascrofulaceum ATCC BAA-614] Length=452 Score = 728 bits (1879), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/449 (80%), Positives = 400/449 (90%), Gaps = 0/449 (0%) Query 2 SAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEF 61 S +PRVSGG +EHGHLEEFRTDPIGLM+RVR+ECGDVG FQL K V+LLSG+ ANEF Sbjct 3 STAVVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLVDKHVILLSGAGANEF 62 Query 62 FFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQV 121 FFR+ D+DLDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGEQMKGHA TIE +V Sbjct 63 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHATTIEGEV 122 Query 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAY 181 ++MIADWG+ GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YHELERGTDPL Y Sbjct 123 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHELERGTDPLCY 182 Query 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 VDPYLPIESF+RRDEAR LVALV +IM+ R+ANPP DK+DRDMLDVL+++K E G PRF Sbjct 183 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGNPRF 242 Query 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 SADE+TGMFIS+MFAGHHTSSGT++WTLIEL+RH D YA V+ EL+ELY DG+ VSFHAL Sbjct 243 SADEVTGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLTELEELYADGQEVSFHAL 302 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 R IP+L+NV+KETLRLHPPLIILMRVAKGEFEV+G IH GD VAASPAISNRIPEDFPD Sbjct 303 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHAGDYVAASPAISNRIPEDFPD 362 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 P F P RY +P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMAQ Sbjct 363 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEFEMAQ 422 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRRTG 450 P +SY NDHSKMVVQLA+PA VRYR+R Sbjct 423 PADSYHNDHSKMVVQLARPAKVRYRKRKA 451 >gi|254818459|ref|ZP_05223460.1| cytochrome P450 51 [Mycobacterium intracellulare ATCC 13950] Length=450 Score = 727 bits (1876), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/450 (79%), Positives = 403/450 (90%), Gaps = 0/450 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLM+RVRDECGDVG FQLAGK V+LLSG+ ANE Sbjct 1 MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMKRVRDECGDVGWFQLAGKHVILLSGASANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D+DLDQA+AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGEQMKGHA+TIE + Sbjct 61 FFFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V++MIADWG+ GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YHELERGTDPL Sbjct 121 VKKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHELERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYLPI+SFRRRDEAR LVA+V +IM+ R+ANPP DK+DRDMLDVL+++K E G R Sbjct 181 YVDPYLPIDSFRRRDEARVKLVAVVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGNLR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSADE+TGMFIS+MFAGHHTSSGT++WTLIEL+RH + YA V+ EL+ELY DG+ VSFHA Sbjct 241 FSADEVTGMFISLMFAGHHTSSGTSAWTLIELIRHPEVYAEVLAELEELYADGQEVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LR IP+L+NV+KETLRLHPPLIILMRVAKGEFEV+G IH GD VAASPAISNRIPEDFP Sbjct 301 LRSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHNGDYVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP F P RY +P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREY+FEMA Sbjct 361 DPDAFRPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTG 450 QP +SY NDHSKMVVQLA+PA VRYR+R Sbjct 421 QPADSYHNDHSKMVVQLARPAKVRYRKRNA 450 >gi|118473009|ref|YP_890090.1| cytochrome P450 [Mycobacterium smegmatis str. MC2 155] gi|118174296|gb|ABK75192.1| cytochrome P450 51 [Mycobacterium smegmatis str. MC2 155] Length=451 Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/444 (80%), Positives = 395/444 (89%), Gaps = 0/444 (0%) Query 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 +PRVSGG +EHGHLEEFRTDPIGLM+RVR ECGDVG FQLA KQVVLLSG+ ANEFFFR+ Sbjct 7 VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS 66 Query 66 GDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMI 125 D +L+QA+AYPFMTPIFGEGVVFDA PERR EMLHN ALRGEQMKGHAATIE++VRRM+ Sbjct 67 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV 126 Query 126 ADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPY 185 WG+ GEIDLL+FFAELTIYTS+ACLIG KFR+QLD RFA YH LERGTDPL YVDPY Sbjct 127 ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 186 Query 186 LPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADE 245 LPIESFR RDEAR LV LV ++MNGRIANPP DKSDRD+LDVL+++K E GTPRFSA+E Sbjct 187 LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 246 Query 246 ITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIP 305 +TGMFIS+MFAGHHTSSGTASWTLIEL+RH + YA V ELD+LY DG+ +SFHALRQIP Sbjct 247 VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 306 Query 306 QLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDF 365 L+N LKETLRLHPPLIILMRVA+ EFEV G IH+G +VAASPAISNRIPEDFPDP F Sbjct 307 NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 366 Query 366 VPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPES 425 P RY++PRQEDL+NRWTWIPFGAG+HRCVGAAFA MQIKAIFSVLLR++EFEMAQP ES Sbjct 367 DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 426 Query 426 YRNDHSKMVVQLAQPACVRYRRRT 449 YRNDHSKMVVQLA+PA VRYRRR Sbjct 427 YRNDHSKMVVQLARPAKVRYRRRV 450 >gi|111021643|ref|YP_704615.1| cytochrome P450 [Rhodococcus jostii RHA1] gi|110821173|gb|ABG96457.1| cytochrome P450 CYP51 [Rhodococcus jostii RHA1] Length=450 Score = 722 bits (1864), Expect = 0.0, Method: Compositional matrix adjust. Identities = 344/449 (77%), Positives = 387/449 (87%), Gaps = 0/449 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ RVSGG EHGHLEE RTDPI LM+RVR+ECG+VG FQLA K+VVLLSG+ ANE Sbjct 1 MNLATPQRVSGGEHEHGHLEELRTDPIALMRRVREECGNVGVFQLADKKVVLLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D+DLDQ AYPFM PIFGEGVVFDASPERRKEMLHN ALRGEQMKGHAATI + Sbjct 61 FFFRSTDEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNQALRGEQMKGHAATIAHE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V RM+A WG+ GEIDLL+FFAELTIYTSSACLIGKKFR+QLDGRFA LYHELE+GTDP+A Sbjct 121 VDRMVAQWGDEGEIDLLEFFAELTIYTSSACLIGKKFREQLDGRFAHLYHELEQGTDPIA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVD Y PIESFRRRDEAR LVALV +IMNGRI NPP K DRDMLDVL+++K E G R Sbjct 181 YVDAYAPIESFRRRDEARVQLVALVQEIMNGRIENPPQGKEDRDMLDVLVSIKDEDGNER 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 F+ADEITGMFISMMFAGHHT+SGTA+WTLIEL+RH D V+ ELD+LY DG +SF A Sbjct 241 FTADEITGMFISMMFAGHHTTSGTAAWTLIELLRHPDYAKQVVAELDDLYSDGSDISFGA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+LE VLKETLRLHPPLIIL+RVA+GEFEV G+RI E DLVAA+PAISNRI EDFP Sbjct 301 LRQIPKLEAVLKETLRLHPPLIILLRVARGEFEVGGYRIAENDLVAATPAISNRIAEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 +P F P RY P QED++NRWTWIPFGAGRHRCVGAAFA+MQ+KAIFS+LL+++EFEMA Sbjct 361 NPDTFDPERYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFALMQLKAIFSILLQDWEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRT 449 QP E+YRNDHSKMVVQL QP VRYR+R+ Sbjct 421 QPSETYRNDHSKMVVQLQQPCTVRYRKRS 449 >gi|193248879|dbj|BAG50430.1| cytochrome P450 [Mycobacterium diernhoferi] Length=454 Score = 721 bits (1860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/450 (79%), Positives = 397/450 (89%), Gaps = 0/450 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ +PRVSGG +EHGHLEEFRTDPIGLMQRVR ECGDVG FQLA KQVVLLSG+ ANE Sbjct 1 MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRQECGDVGWFQLADKQVVLLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D +L+QA+AYPFMTPIFGEGVVFDA PERR EMLHN ALRGEQMKGHAATIE++ Sbjct 61 FFFRSSDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V+++IADWG+ GEI+LLDFF+ELTIYTS+ACLIG KFR+QLD RFA YH+LERGTDPL Sbjct 121 VKKIIADWGDEGEIELLDFFSELTIYTSTACLIGLKFREQLDSRFAHYYHQLERGTDPLC 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPYL IESFR RDE+R LVALV +IM+GRIANPP K DRD+LDVL+++K + G PR Sbjct 181 YVDPYLDIESFRIRDESRVKLVALVQEIMDGRIANPPKGKEDRDLLDVLVSIKDDEGNPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 F+A+E+TGMFIS+MFAGHHTSSGT++WTLIEL+RH D YA V ELDELY DG+ VSFHA Sbjct 241 FTANEVTGMFISLMFAGHHTSSGTSAWTLIELIRHADVYADVRAELDELYADGQEVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+L+NV+KETLRLHPPLIILMRVA+ EFEV+G IH+GD VAASPAISNRIPEDFP Sbjct 301 LRQIPKLDNVVKETLRLHPPLIILMRVAQDEFEVKGLPIHKGDFVAASPAISNRIPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP F+P RY +P Q D+ NRWTWIPFGAG+HRCVGAAFA MQIKAIFSVLLREYEFEMA Sbjct 361 DPDAFLPDRYNKPEQADIANRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRTG 450 Q PESYRNDHSKMVVQLAQPA VRYRRR Sbjct 421 QSPESYRNDHSKMVVQLAQPAKVRYRRRAS 450 >gi|254818478|ref|ZP_05223479.1| cytochrome P450 51 [Mycobacterium intracellulare ATCC 13950] Length=457 Score = 719 bits (1856), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/448 (79%), Positives = 399/448 (90%), Gaps = 0/448 (0%) Query 2 SAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEF 61 S + +PRVSGG +EHGHLEEFRTDPIGLM+RVRDECGDVG FQL K V+LLSG+ ANEF Sbjct 3 STMIVPRVSGGEEEHGHLEEFRTDPIGLMKRVRDECGDVGWFQLVDKHVILLSGAGANEF 62 Query 62 FFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQV 121 FFR+ D+DLDQA AYPFMTPIFG+GVVFDASPERRKEMLHN+ALRGEQMKGHAATIE +V Sbjct 63 FFRSADEDLDQAAAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHAATIEGEV 122 Query 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAY 181 ++MIADWG+ GEI+LLDFFAELTIYTS+ACLIG KFR+QLD RFA+ YHELERGTDPL Y Sbjct 123 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHELERGTDPLCY 182 Query 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 VDPYLPI+SFR RDEAR LVA+V +IM+ R ANPP DK+DRDMLDVL+++K E G RF Sbjct 183 VDPYLPIDSFRHRDEARIKLVAVVQEIMDQRQANPPKDKADRDMLDVLVSIKDEDGNLRF 242 Query 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 SADE+TGMFIS+MFAGHHTSSGT++WTLIEL+RH + YA V+ EL+ELY DG+ VSFHAL Sbjct 243 SADEVTGMFISLMFAGHHTSSGTSAWTLIELIRHPEVYAEVLAELEELYADGQEVSFHAL 302 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 R IP+L+NV+KETLRLHPPLIILMRVAKGEFEV+G IH+GD VAASPAISNRIPEDFPD Sbjct 303 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHDGDFVAASPAISNRIPEDFPD 362 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 P F P RY +P Q D++NRWTWIPFGAGRHRCVGAAFA MQIKAIFSVLLREYEFEMAQ Sbjct 363 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEFEMAQ 422 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRRT 449 P +SY NDHSKMVVQLA+PA VRYR+R Sbjct 423 PADSYHNDHSKMVVQLARPAKVRYRKRN 450 >gi|226364180|ref|YP_002781962.1| cytochrome P450 51 [Rhodococcus opacus B4] gi|226242669|dbj|BAH53017.1| cytochrome P450 51 [Rhodococcus opacus B4] Length=450 Score = 716 bits (1849), Expect = 0.0, Method: Compositional matrix adjust. Identities = 342/449 (77%), Positives = 387/449 (87%), Gaps = 0/449 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ V RVSGG EHGHLEE RTDPI LM+RVR+ECG+VG FQLA K+VVLLSG+ ANE Sbjct 1 MNLVTPQRVSGGEHEHGHLEELRTDPIALMRRVREECGNVGVFQLADKKVVLLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+ D+DLDQ AYPFM PIFGEGVVFDASPERRKEMLHN ALRGEQMKGHAATI + Sbjct 61 FFFRSTDEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNQALRGEQMKGHAATIAHE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V R++A WG+ GEIDLL+FFAELTIYTSSACLIGKKFR+QLDGRFA LYHELE+GTDP+A Sbjct 121 VDRVVARWGDEGEIDLLEFFAELTIYTSSACLIGKKFREQLDGRFAHLYHELEQGTDPIA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVD Y IESFRRRDEAR LVALV +IM GRIANPP K DRDMLDVL+++K E G R Sbjct 181 YVDAYADIESFRRRDEARVQLVALVQEIMTGRIANPPQGKEDRDMLDVLVSIKDENGDER 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 F+ADEITGMFISMMFAGHHT+SGTA+WTLIEL+RH D V+ ELD+LY DG +SF A Sbjct 241 FTADEITGMFISMMFAGHHTTSGTAAWTLIELLRHPDYAKQVVAELDDLYSDGSDISFGA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP+LE VLKETLR+HPPLIIL+RVA+GEFEV G+RI E DLVAA+PAISNRI EDFP Sbjct 301 LRQIPKLEAVLKETLRMHPPLIILLRVARGEFEVGGYRIAENDLVAATPAISNRIAEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 +P F P RY P QED++NRWTWIPFGAGRHRCVGAAFA+MQ+KAIFS+LL+++EFEMA Sbjct 361 NPDTFDPERYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFALMQLKAIFSILLQDWEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPACVRYRRRT 449 QP E+YRNDHSKMVVQL QP VRYR+R+ Sbjct 421 QPSETYRNDHSKMVVQLQQPCTVRYRKRS 449 >gi|54024558|ref|YP_118800.1| cytochrome P450 monooxygenase [Nocardia farcinica IFM 10152] gi|54016066|dbj|BAD57436.1| cytochrome P450 monooxygenase [Nocardia farcinica IFM 10152] Length=452 Score = 706 bits (1822), Expect = 0.0, Method: Compositional matrix adjust. Identities = 340/441 (78%), Positives = 378/441 (86%), Gaps = 0/441 (0%) Query 1 MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE 60 M+ V RVSGG EHGHLEEFRTDPI LM+RVR ECGDVG F+LAGKQV+LLSG+ ANE Sbjct 1 MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFELAGKQVILLSGAEANE 60 Query 61 FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ 120 FFFR+GD+DLDQ AYPFM PIFGEGVVFDASPERRKEMLHN+ALR EQM+GHA TI + Sbjct 61 FFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHNSALRAEQMRGHATTIAAE 120 Query 121 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA 180 V RMIA W + GEIDLLDFFAELTIYTSSACLIG KFR++LD RFA+LYHELERGTD LA Sbjct 121 VDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNELDDRFARLYHELERGTDALA 180 Query 181 YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR 240 YVDPY PIESFRRRDEAR LVALV IM+ R ANPP DKSDRD+LDVL++V E G PR Sbjct 181 YVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPADKSDRDLLDVLVSVPNEDGGPR 240 Query 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 FSA EITG+FISMMFAGHHT+SGTA+WT+IEL+RH + V+ ELDEL+ DG+ VSFHA Sbjct 241 FSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHPELRDRVVAELDELFADGKDVSFHA 300 Query 301 LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 LRQIP LE LKETLR+HPPLIILMRVA+G+FEV GH I GD VAA+PAISNR+PEDFP Sbjct 301 LRQIPLLEATLKETLRMHPPLIILMRVAQGDFEVCGHHIAAGDHVAATPAISNRLPEDFP 360 Query 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 DP F P RY P QEDL+NRWTWIPFGAGRHRCVGAAFA+MQ+KAIFS+LLR++EFEMA Sbjct 361 DPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRHRCVGAAFALMQLKAIFSILLRDWEFEMA 420 Query 421 QPPESYRNDHSKMVVQLAQPA 441 QP ESYRNDHSKMVVQL QP Sbjct 421 QPSESYRNDHSKMVVQLQQPC 441 >gi|226306864|ref|YP_002766824.1| cytochrome P450 51 [Rhodococcus erythropolis PR4] gi|226185981|dbj|BAH34085.1| cytochrome P450 51 [Rhodococcus erythropolis PR4] Length=464 Score = 703 bits (1814), Expect = 0.0, Method: Compositional matrix adjust. Identities = 338/437 (78%), Positives = 374/437 (86%), Gaps = 0/437 (0%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 PRVSGG HGHLEE RTDPI LM+RVR+ECGDVG FQLA + V+LLSG+ ANEFFFR+ Sbjct 16 PRVSGGDLPHGHLEELRTDPIALMRRVREECGDVGAFQLADRTVILLSGAEANEFFFRST 75 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIA 126 D+DLDQ AYPFM PIFGEGVVFDASPERRKEMLHN+ALRGEQM+GHAATI +V M+A Sbjct 76 DEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNSALRGEQMRGHAATIGREVEAMVA 135 Query 127 DWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL 186 WG+ GEIDLLDFFAELTIYTSSACLIGKKFRD+LD FAKLYHELE+GTD LA+VDPY Sbjct 136 QWGDEGEIDLLDFFAELTIYTSSACLIGKKFRDELDDSFAKLYHELEQGTDALAFVDPYA 195 Query 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEI 246 PIESFRRRDEAR LVALV DIMNGRIANPP K DRDMLDVL++VK E G RFSADEI Sbjct 196 PIESFRRRDEARLALVALVQDIMNGRIANPPQGKEDRDMLDVLVSVKDENGDLRFSADEI 255 Query 247 TGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQ 306 TG+FISMMFAGHHT+SGTA+W+LIE++RH D V+DELD LY DG +SFHALRQIP Sbjct 256 TGIFISMMFAGHHTTSGTAAWSLIEMLRHPDTMTDVVDELDNLYSDGADISFHALRQIPV 315 Query 307 LENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFV 366 LE V+KETLRLHPPLIIL+RVA+G+FEV G I EG LVAA+PAISNRI EDFP P F Sbjct 316 LEAVVKETLRLHPPLIILLRVARGDFEVGGFEIREGHLVAATPAISNRIAEDFPRPDTFD 375 Query 367 PARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESY 426 P RY P QED++NRWTWIPFGAGRHRCVGAAFA MQ+KAIFS+LLR++EFEMAQP ESY Sbjct 376 PGRYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFAQMQLKAIFSILLRDFEFEMAQPSESY 435 Query 427 RNDHSKMVVQLAQPACV 443 RNDHSKMVVQL QP V Sbjct 436 RNDHSKMVVQLQQPCAV 452 >gi|229492759|ref|ZP_04386560.1| cytochrome p450 51 [Rhodococcus erythropolis SK121] gi|229320418|gb|EEN86238.1| cytochrome p450 51 [Rhodococcus erythropolis SK121] Length=464 Score = 700 bits (1806), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/437 (78%), Positives = 373/437 (86%), Gaps = 0/437 (0%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 PRVSGG HGHLEE RTDPI LM+RVR+ECGDVG FQLA + V+LLSG+ ANEFFFR+ Sbjct 16 PRVSGGDLPHGHLEELRTDPIALMRRVREECGDVGAFQLADRTVILLSGAEANEFFFRST 75 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIA 126 D+DLDQ AYPFM PIFGEGVVFDASPERRKEMLHN+ALRGEQM+GHAATI +V M+A Sbjct 76 DEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNSALRGEQMRGHAATIGREVEAMVA 135 Query 127 DWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL 186 WG+ GEIDLLDFFAELTIYTSSACLIGKKFRD+LD FAKLYHELE+GTD LA+VDPY Sbjct 136 QWGDEGEIDLLDFFAELTIYTSSACLIGKKFRDELDDSFAKLYHELEQGTDALAFVDPYA 195 Query 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEI 246 PIESFRRRDEAR LVALV DIMN RIANPP K DRDMLDVL++VK E G RFSADEI Sbjct 196 PIESFRRRDEARLALVALVQDIMNRRIANPPQGKDDRDMLDVLVSVKDENGDLRFSADEI 255 Query 247 TGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQ 306 TG+FISMMFAGHHT+SGTA+W+LIE++RH D V+DELD LY DG +SFHALRQIP Sbjct 256 TGIFISMMFAGHHTTSGTAAWSLIEMLRHPDTMTDVVDELDNLYSDGADISFHALRQIPV 315 Query 307 LENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFV 366 LE V+KETLRLHPPLIIL+RVA+G+FEV G I EG LVAA+PAISNRI EDFP P F Sbjct 316 LEAVVKETLRLHPPLIILLRVARGDFEVGGFEIREGHLVAATPAISNRIAEDFPRPDTFD 375 Query 367 PARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESY 426 P RY P QED++NRWTWIPFGAGRHRCVGAAFA MQ+KAIFS+LLR++EFEMAQP ESY Sbjct 376 PGRYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFAQMQLKAIFSILLRDFEFEMAQPSESY 435 Query 427 RNDHSKMVVQLAQPACV 443 RNDHSKMVVQL QP V Sbjct 436 RNDHSKMVVQLQQPCAV 452 >gi|312138815|ref|YP_004006151.1| cytochrome p450 monooxygenase [Rhodococcus equi 103S] gi|311888154|emb|CBH47466.1| cytochrome P450 monooxygenase [Rhodococcus equi 103S] Length=473 Score = 687 bits (1773), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/435 (76%), Positives = 370/435 (86%), Gaps = 0/435 (0%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 PRVSGG EHGHLEE RTDPI LM+RVR+ECGDVG F+L + VVLL+G+ ANEFFFR+ Sbjct 7 PRVSGGLHEHGHLEELRTDPIALMRRVREECGDVGVFRLVDRDVVLLTGAEANEFFFRSS 66 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIA 126 D+DLDQ AYPFM PIFGEGVVFDASPERR EMLHN+ALRGEQM+GHA TI +V M++ Sbjct 67 DEDLDQQAAYPFMKPIFGEGVVFDASPERRSEMLHNSALRGEQMRGHATTIGGEVEDMVS 126 Query 127 DWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL 186 WG+ GEIDLL+FFAELTIYTSSACLIGKKFRD+LD RFAKLYHELE+GTD +A+VDPY Sbjct 127 RWGDEGEIDLLEFFAELTIYTSSACLIGKKFRDELDDRFAKLYHELEQGTDAIAFVDPYA 186 Query 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEI 246 PIESFRRRD AR LV LV IMNGR+ANPP K DRDMLDVL++++ + G RFSADEI Sbjct 187 PIESFRRRDAARVALVELVQGIMNGRVANPPRGKEDRDMLDVLVSIRDDEGNLRFSADEI 246 Query 247 TGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQ 306 TG+FISMMFAGHHT+SGTA+W+LIEL+RH D V ELDELY DG +SFHALRQIP Sbjct 247 TGIFISMMFAGHHTTSGTAAWSLIELLRHPDTMQQVTAELDELYADGADISFHALRQIPV 306 Query 307 LENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFV 366 LE V+KETLRLHPPLIIL+RVA+G+FEV G IHEG+LVAA+PAISNRIPEDFP+P F Sbjct 307 LEAVIKETLRLHPPLIILLRVARGDFEVGGFSIHEGNLVAATPAISNRIPEDFPEPDSFH 366 Query 367 PARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESY 426 P RY P QED NRWTWIPFGAGRHRCVGAAFA MQ+KAIFS+LLR++EFEMAQP +SY Sbjct 367 PGRYIDPNQEDTANRWTWIPFGAGRHRCVGAAFAQMQLKAIFSILLRDFEFEMAQPADSY 426 Query 427 RNDHSKMVVQLAQPA 441 RNDHSKMVVQL QP Sbjct 427 RNDHSKMVVQLQQPC 441 >gi|325676485|ref|ZP_08156163.1| cytochrome P450 51 [Rhodococcus equi ATCC 33707] gi|325552663|gb|EGD22347.1| cytochrome P450 51 [Rhodococcus equi ATCC 33707] Length=473 Score = 686 bits (1771), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/435 (76%), Positives = 370/435 (86%), Gaps = 0/435 (0%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 PRVSGG EHGHLEE RTDPI LM+RVR+ECGDVG F+L + VVLL+G+ ANEFFFR+ Sbjct 7 PRVSGGLHEHGHLEELRTDPIALMRRVREECGDVGVFRLVDRDVVLLTGAEANEFFFRSS 66 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIA 126 D+DLDQ AYPFM PIFGEGVVFDASPERR EMLHN+ALRGEQM+GHA TI +V M++ Sbjct 67 DEDLDQQAAYPFMKPIFGEGVVFDASPERRSEMLHNSALRGEQMRGHATTIGGEVEDMVS 126 Query 127 DWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL 186 WG+ GEIDLL+FFAELTIYTSSACLIGKKFRD+LD RFAKLYHELE+GTD +A+VDPY Sbjct 127 RWGDEGEIDLLEFFAELTIYTSSACLIGKKFRDELDDRFAKLYHELEQGTDAIAFVDPYA 186 Query 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEI 246 PIESFRRRD AR LV LV IMNGR+ANPP K DRDMLDVL++++ + G RFSADEI Sbjct 187 PIESFRRRDAARVALVELVQGIMNGRVANPPRGKEDRDMLDVLVSIRDDEGNLRFSADEI 246 Query 247 TGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQ 306 TG+FISMMFAGHHT+SGTA+W+LIEL+RH D V ELDELY DG +SFHALRQIP Sbjct 247 TGIFISMMFAGHHTTSGTAAWSLIELLRHPDTMQQVTAELDELYADGADISFHALRQIPV 306 Query 307 LENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFV 366 LE V+KETLRLHPPLIIL+RVA+G+FEV G IHEG+LVAA+PAISNRIPEDFP+P F Sbjct 307 LEAVIKETLRLHPPLIILLRVARGDFEVGGFSIHEGNLVAATPAISNRIPEDFPEPDSFH 366 Query 367 PARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESY 426 P RY P QED NRWTWIPFGAGRHRCVGAAFA MQ+KAIFS+LLR++EFEMAQP +SY Sbjct 367 PGRYIDPNQEDTANRWTWIPFGAGRHRCVGAAFAQMQLKAIFSILLRDFEFEMAQPADSY 426 Query 427 RNDHSKMVVQLAQPA 441 RNDHSKMVVQL QP Sbjct 427 RNDHSKMVVQLQQPC 441 >gi|319950412|ref|ZP_08024328.1| cytochrome P450 CYP51 [Dietzia cinnamea P4] gi|319435928|gb|EFV91132.1| cytochrome P450 CYP51 [Dietzia cinnamea P4] Length=460 Score = 652 bits (1683), Expect = 0.0, Method: Compositional matrix adjust. Identities = 308/442 (70%), Positives = 364/442 (83%), Gaps = 0/442 (0%) Query 8 RVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGD 67 RVSGG E GH++E RTDPI L RVR+ECG++G F++A + + L SG+ ANE FFRA D Sbjct 18 RVSGGEGELGHMDELRTDPISLFWRVREECGELGIFRIADRDICLASGAAANEAFFRAPD 77 Query 68 DDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIAD 127 + LDQA AYPFMTP+FGEGVVFDASPERR EMLHN ALRGE M+ HA TI +V RM+AD Sbjct 78 ESLDQAAAYPFMTPVFGEGVVFDASPERRSEMLHNTALRGEHMRQHAVTIPREVERMVAD 137 Query 128 WGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLP 187 WG+ GEIDLL++F+ELTIYTSSACLIG KFR+QLD RFA LYH+LE+GTDP AY+DPY Sbjct 138 WGDEGEIDLLEWFSELTIYTSSACLIGPKFREQLDARFAHLYHDLEQGTDPHAYIDPYAD 197 Query 188 IESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEIT 247 IESFRRRD AR GLV LV+ IM+ RIANPP DK DRD+LDVL+++K E GT RF+ +E+T Sbjct 198 IESFRRRDAAREGLVELVSAIMDERIANPPADKEDRDLLDVLVSIKDEDGTHRFTPNEVT 257 Query 248 GMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQL 307 G+FISMMFAGHHT+SGT++W LIEL+RH + V+ ELDE+Y DG SF ALRQ+P++ Sbjct 258 GIFISMMFAGHHTTSGTSAWMLIELLRHPEYMQQVLAELDEIYADGAEYSFGALRQMPKV 317 Query 308 ENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP 367 EN LKETLRLHPPLIILMRVA+ + ++ + G VAASPA+SNR+PEDFPD F P Sbjct 318 ENALKETLRLHPPLIILMRVAQDDVKIDDFVVRAGQTVAASPAVSNRLPEDFPDADSFDP 377 Query 368 ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYR 427 RY +PRQED++NRWTWIPFGAGRHRCVGAAFA +QIKAIFSVLLREYEFE+AQP ESY Sbjct 378 DRYAEPRQEDIVNRWTWIPFGAGRHRCVGAAFAQLQIKAIFSVLLREYEFELAQPEESYH 437 Query 428 NDHSKMVVQLAQPACVRYRRRT 449 NDHSKMVVQLAQP VRYR+R Sbjct 438 NDHSKMVVQLAQPCKVRYRKRV 459 >gi|326384238|ref|ZP_08205920.1| cytochrome P450 [Gordonia neofelifaecis NRRL B-59395] gi|326197103|gb|EGD54295.1| cytochrome P450 [Gordonia neofelifaecis NRRL B-59395] Length=494 Score = 625 bits (1613), Expect = 4e-177, Method: Compositional matrix adjust. Identities = 296/430 (69%), Positives = 351/430 (82%), Gaps = 0/430 (0%) Query 8 RVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGD 67 RVSGG EHGHL+E TDPIGL +RVRDE G+VG FQLA ++VVL+SG+ ANE FFRA D Sbjct 11 RVSGGEGEHGHLDELATDPIGLFRRVRDEHGEVGMFQLADREVVLVSGAAANEEFFRAPD 70 Query 68 DDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIAD 127 + LDQ AYPFMTPIFGEGVVFD SPERR EMLHN AL+G MK HA TI D+V RMIAD Sbjct 71 EVLDQGAAYPFMTPIFGEGVVFDTSPERRSEMLHNQALKGAHMKQHAVTIPDEVERMIAD 130 Query 128 WGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLP 187 WG+ GEIDLLDFFAELT+YTSS+CLIG+KFR++L G A LYHELE+GTDP+AYVD + Sbjct 131 WGDEGEIDLLDFFAELTLYTSSSCLIGRKFREELSGHIAHLYHELEKGTDPIAYVDMHAD 190 Query 188 IESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEIT 247 IESFRRRD AR LV + +M+ RIANPP DK DRD+LDVL+++K + G+ F+ D +T Sbjct 191 IESFRRRDAARAELVEFIGGVMDRRIANPPADKEDRDLLDVLVSLKNDDGSQMFTPDTVT 250 Query 248 GMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQL 307 G+FISMMFAGHHT+SGTA+WTLIEL++H D A V ELD +Y DG SF A+RQIP+L Sbjct 251 GIFISMMFAGHHTTSGTAAWTLIELLKHPDYLAEVTGELDGIYSDGTEYSFAAMRQIPKL 310 Query 308 ENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP 367 E +KE LRLHPPLIILMR+ + +FEV G +H+G +A SPA+SNR+PEDFP+P F P Sbjct 311 EGAIKEALRLHPPLIILMRLVQEDFEVGGVTVHKGQSIAVSPAVSNRLPEDFPNPDAFDP 370 Query 368 ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYR 427 ARY++PRQEDL+NRWTWIPFGAGRHRCVGA FA+MQ+KAIFSVLLR YEF + Q +SYR Sbjct 371 ARYDEPRQEDLVNRWTWIPFGAGRHRCVGAQFAMMQLKAIFSVLLRNYEFSLVQDADSYR 430 Query 428 NDHSKMVVQL 437 NDHSKMVVQL Sbjct 431 NDHSKMVVQL 440 >gi|262203706|ref|YP_003274914.1| cytochrome P450 [Gordonia bronchialis DSM 43247] gi|262087053|gb|ACY23021.1| cytochrome P450 [Gordonia bronchialis DSM 43247] Length=451 Score = 615 bits (1585), Expect = 6e-174, Method: Compositional matrix adjust. Identities = 299/457 (66%), Positives = 356/457 (78%), Gaps = 13/457 (2%) Query 1 MSAVALPR-VSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHAN 59 M+A+ PR VSGG EHGHL+E TDPI L RVRDECGDVG FQLA ++VVL+SG+ AN Sbjct 1 MTALTKPRLVSGGDGEHGHLDELATDPISLFWRVRDECGDVGLFQLADREVVLVSGAAAN 60 Query 60 EFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIED 119 E FFRA ++DLDQA AYPFMTP+FGEGVVFDASPE R + +HN+AL+G MK HA TI + Sbjct 61 EEFFRAPEEDLDQAAAYPFMTPVFGEGVVFDASPEERSKAIHNSALKGPHMKQHAVTIPN 120 Query 120 QVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPL 179 +V R+IA WG+ GEIDLL+FF ELT+YTSSACLIG+KFR+QLD R ++L+H+LE+GTDP+ Sbjct 121 EVERIIAQWGDEGEIDLLEFFGELTLYTSSACLIGRKFREQLDKRVSELFHDLEKGTDPI 180 Query 180 AYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTP 239 AYVD + IESFR+RD AR LV + +MN RIANP DK DRD++D+LI V Sbjct 181 AYVDAHADIESFRKRDAARAELVEFIQGVMNDRIANPVEDKDDRDLMDILIQVG------ 234 Query 240 RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRS---- 295 F A+ ITGMFISMMFAGHHT+ GTA+WTLIEL+R+ D A V ELDE+YGD + Sbjct 235 -FDANTITGMFISMMFAGHHTTQGTAAWTLIELLRNPDYMARVYAELDEIYGDTPAGERP 293 Query 296 -VSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNR 354 +F RQ+PQLEN LKE LRLHPPLIILMR+ + +F V+ + G +A SPA+SNR Sbjct 294 EYTFAHTRQMPQLENALKEALRLHPPLIILMRLVQQDFHVEDFEVKAGQTIAVSPAVSNR 353 Query 355 IPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLRE 414 IPEDFPDP F P RY +PR EDL+NRWTWIPFGAGRHRCVGA FAIMQ+KAIFSVL + Sbjct 354 IPEDFPDPDVFDPDRYNKPRTEDLVNRWTWIPFGAGRHRCVGAQFAIMQLKAIFSVLFQN 413 Query 415 YEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV 451 YEFEM QP ESYRNDH+KMVVQL QP V YRRR+GV Sbjct 414 YEFEMLQPSESYRNDHTKMVVQLQQPCRVAYRRRSGV 450 >gi|343927847|ref|ZP_08767315.1| cytochrome P450 51 [Gordonia alkanivorans NBRC 16433] gi|343762488|dbj|GAA14241.1| cytochrome P450 51 [Gordonia alkanivorans NBRC 16433] Length=455 Score = 608 bits (1568), Expect = 5e-172, Method: Compositional matrix adjust. Identities = 294/447 (66%), Positives = 349/447 (79%), Gaps = 12/447 (2%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 PRVSGG EHGHL+E TDPI L RVR+ECGDVG FQLA ++VVL+SG+ ANE FFRA Sbjct 13 PRVSGGEGEHGHLDELATDPISLFWRVREECGDVGLFQLADREVVLVSGAAANEEFFRAP 72 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIA 126 ++DLDQA AYPFMTP+FGEGVVFDASPE R + +HN+AL+G MK HA TI ++V R+IA Sbjct 73 EEDLDQAAAYPFMTPVFGEGVVFDASPEERSKAIHNSALKGAHMKQHAVTIPNEVERIIA 132 Query 127 DWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL 186 +WG+ GEIDLLDFF+ELT+YTSSACLIG+KFR++L A L+H+LE+GTDP+AYVD Sbjct 133 EWGDEGEIDLLDFFSELTLYTSSACLIGRKFRERLSAHIAHLFHDLEKGTDPIAYVDYNA 192 Query 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEI 246 IESFR+RDEAR LV + +M+ RIANP DK DRD++DVL+ V F A+ + Sbjct 193 DIESFRKRDEARAELVEFIQGVMDERIANPTQDKEDRDLMDVLVQVG-------FDANTV 245 Query 247 TGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDG-----RSVSFHAL 301 TGMFISMMFAGHHT+SGTA+WTLIEL+R+ D V DELDE+YGD +F Sbjct 246 TGMFISMMFAGHHTTSGTAAWTLIELLRNPDYMKRVYDELDEIYGDTPDGERPEYTFAHT 305 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 RQ+PQLEN LKE LRLHPPLIILMRV + F V+ + I G +A SPA+SNR+PEDFPD Sbjct 306 RQMPQLENALKEALRLHPPLIILMRVVQRNFHVEDYEIAAGQSIAVSPAVSNRLPEDFPD 365 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 F P RYE+PRQEDL+NRWTWIPFGAGRHRCVGA FAIMQ+KAIFSVL + YEFEM Q Sbjct 366 ADAFDPDRYEKPRQEDLVNRWTWIPFGAGRHRCVGAQFAIMQLKAIFSVLFQNYEFEMLQ 425 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRR 448 P ESY+NDHSKMVVQL QP V YR+R Sbjct 426 PSESYQNDHSKMVVQLQQPCRVAYRKR 452 >gi|326331689|ref|ZP_08197977.1| cytochrome P450 51 [Nocardioidaceae bacterium Broad-1] gi|325950488|gb|EGD42540.1| cytochrome P450 51 [Nocardioidaceae bacterium Broad-1] Length=450 Score = 583 bits (1503), Expect = 2e-164, Method: Compositional matrix adjust. Identities = 289/457 (64%), Positives = 344/457 (76%), Gaps = 18/457 (3%) Query 4 VALPRVSGGHDEH-----------GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVL 52 + +P VS D+H GHL E R DPI L RVR+ECGD+G F+LA K VVL Sbjct 1 MTIPTVSTVLDDHDPSVPEIIRGTGHLPEMRVDPISLFTRVREECGDLGRFRLADKDVVL 60 Query 53 LSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKG 112 ++G+ ANE FFRA DD LDQA AYPFMTPIFG+GVVFDASPE R++ML N ALRG+ M+G Sbjct 61 VTGAEANEAFFRAPDDVLDQAAAYPFMTPIFGKGVVFDASPEERQQMLKNQALRGDMMRG 120 Query 113 HAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHEL 172 HA TIE ++RRMIA WGE GEIDLLDFFAELTIYT+SACL+GK FR++LD FA+ YHEL Sbjct 121 HAQTIEAEIRRMIAGWGEEGEIDLLDFFAELTIYTTSACLVGKPFREELDSSFAQHYHEL 180 Query 173 ERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAV 232 E GTD +AYVD Y IE+FR RD AR LVALV I++ R+A + +RD+LDVLI++ Sbjct 181 EHGTDAIAYVDAYADIENFRMRDAARERLVALVQAIVDKRVARGKVPREERDLLDVLISI 240 Query 233 KAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD 292 +T D ITG+FISMMFAGHHTSSGTASW +IEL+R+ + V+ ELDELY D Sbjct 241 DMDT-------DTITGIFISMMFAGHHTSSGTASWAMIELLRNPEVMGDVVHELDELYAD 293 Query 293 GRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAIS 352 G VSF ALR IP LE LKETLRLHPPLIILMR+ + +FE+ G I G L+AASP +S Sbjct 294 GSEVSFQALRSIPVLEAALKETLRLHPPLIILMRLVREDFELLGETIPAGTLLAASPRVS 353 Query 353 NRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLL 412 NRI DFP F P+RY PRQED+ NRWTWIPFGAG+HRCVG AFA+MQ+KAIFSV+L Sbjct 354 NRIEADFPKAEAFDPSRYIDPRQEDMQNRWTWIPFGAGKHRCVGNAFAMMQMKAIFSVIL 413 Query 413 REYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRT 449 R+Y FE AQP ESY +D +KMV+QL QP VRYRRR+ Sbjct 414 RDYSFEAAQPLESYADDFTKMVIQLQQPCRVRYRRRS 450 >gi|53803178|ref|YP_115112.1| cytochrome P450 51 [Methylococcus capsulatus str. Bath] gi|53756939|gb|AAU91230.1| cytochrome P450 51 [Methylococcus capsulatus str. Bath] Length=551 Score = 415 bits (1067), Expect = 7e-114, Method: Compositional matrix adjust. Identities = 219/444 (50%), Positives = 289/444 (66%), Gaps = 7/444 (1%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 P GG GH+ EF +P + +R E GDV F++ +++VLL+GS A+E F+RA Sbjct 10 PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 69 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN--AALRGEQMKGHAATIEDQVRRM 124 D+ LDQ AY MTPIFG GVVFDA ER+ + L ALR + M+ ++ I +V M Sbjct 70 DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 129 Query 125 IADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDP 184 + DW +AG IDLL+ ELTIYTSS CL+G +FR +L+ FA +Y +LE G P+AYV P Sbjct 130 LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 189 Query 185 YLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSAD 244 LP+ F+RRD+AR L LV IM R + + ++ +LI + G+ + + Sbjct 190 NLPLPVFKRRDQARVRLQELVTQIMERRAR---SQERSTNVFQMLIDASYDDGS-KLTPH 245 Query 245 EITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQI 304 EITGM I+ +FAGHHTSSGT +W LIEL+R + V E+D L+ V+F +LRQ+ Sbjct 246 EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 305 Query 305 PQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHD 364 PQLENV+KE LRLHPPLI+LMR +FEVQG RI G V A+P++++RIPE FP+P Sbjct 306 PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 365 Query 365 FVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPE 424 F P RY R ED + + W FG GRH+C G AFA+ QIKAI VLLR YEFE+A PE Sbjct 366 FDPDRYTPERAED-KDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE 424 Query 425 SYRNDHSKMVVQLAQPACVRYRRR 448 SYR+D+ KMVV+ A P +RYRRR Sbjct 425 SYRDDYRKMVVEPASPCLIRYRRR 448 >gi|304310752|ref|YP_003810350.1| Cytochrome P450 51 [gamma proteobacterium HdN1] gi|301796485|emb|CBL44693.1| Cytochrome P450 51 [gamma proteobacterium HdN1] Length=585 Score = 413 bits (1061), Expect = 4e-113, Method: Compositional matrix adjust. Identities = 210/447 (47%), Positives = 289/447 (65%), Gaps = 7/447 (1%) Query 4 VALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFF 63 +A P++ GG GH+ F +P M+RV DE G++ F++ +++VLL+G A+ F+ Sbjct 15 LAPPKLKGGVPLLGHIFPFARNPFQFMKRVSDELGEIAQFRIFNQRMVLLTGDAASTLFY 74 Query 64 RAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN--AALRGEQMKGHAATIEDQV 121 R+ DD LDQ+ AY MTPIFGEG+VFDA ER+ + L +LR E M+ H+ I +V Sbjct 75 RSSDDVLDQSAAYKLMTPIFGEGIVFDAPNERKNQQLKMLMPSLRAEAMRHHSDKIVQEV 134 Query 122 RRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAY 181 + WGE GE+DL+ LTI T+S CL+G++FR +L FA +YH+LE+G + LAY Sbjct 135 EDLAQRWGEQGEVDLVAEMKRLTINTASHCLLGREFRYELTDEFASIYHDLEKGVNALAY 194 Query 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 P LPI +FR RD AR L LV++I+ R + DM LI E G+ + Sbjct 195 SFPNLPIPAFRARDRARVRLHQLVSEIVKKRESQA---HKPNDMFQSLIDTHYEDGS-KL 250 Query 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 + DEITG+ I+ +FAGHHTSSGTA+W L+EL++H V +ELD+L+G VSF L Sbjct 251 TTDEITGILIAAIFAGHHTSSGTAAWVLLELLKHPHHLREVRNELDQLFGSDGVVSFQTL 310 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 R+IP LENVLKE LRLHPPLI+LMR +G+RI GD+V ASP +++R+ + FP+ Sbjct 311 REIPHLENVLKEVLRLHPPLIVLMRQVVEPIRFKGYRIEAGDMVWASPPVTHRMSQLFPN 370 Query 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 P F P RYE D N W PFG G+H+C G AFA+ QIKAIFSVLLR+Y+FE+ Sbjct 371 PEVFDPTRYEGDHAAD-KNLMAWQPFGGGKHKCAGNAFALFQIKAIFSVLLRKYDFELVN 429 Query 422 PPESYRNDHSKMVVQLAQPACVRYRRR 448 P++Y +D+ +M+VQ P VRY+RR Sbjct 430 RPDTYVDDYGEMIVQPKSPCMVRYKRR 456 >gi|149917920|ref|ZP_01906414.1| cytochrome P450 51 [Plesiocystis pacifica SIR-1] gi|149821186|gb|EDM80590.1| cytochrome P450 51 [Plesiocystis pacifica SIR-1] Length=465 Score = 366 bits (939), Expect = 5e-99, Method: Compositional matrix adjust. Identities = 193/445 (44%), Positives = 278/445 (63%), Gaps = 7/445 (1%) Query 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 PR+ GG GH EFRT+P+ LM R R+ GDV T + G V+++G+ A E FFR Sbjct 24 PRLEGGLPFLGHSLEFRTNPVSLMARARERHGDVVTLTMPGANAVVMTGTRAQEKFFRLS 83 Query 67 DDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRRM 124 D+D+ QA+AY MTPIFGEG+ +DA P KE L + ALR +M+ +A D+ + Sbjct 84 DEDVSQAEAYRLMTPIFGEGIAYDAPPPIMKEQLSFFHDALREARMRTYAQGFIDEAEQY 143 Query 125 IADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDP 184 + W + G +D+ D ELTIYTSS L+G +FR+QL G FAKLY ++E G LA++ P Sbjct 144 FSSWDDFGCVDMYDVGNELTIYTSSRSLLGVEFRNQLSGEFAKLYQDMEGGLSALAFLAP 203 Query 185 YLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSAD 244 LP +FR+RD+AR +V L+ DI+ R + S DML L+ + G + S + Sbjct 204 NLPTPAFRKRDKARARMVELITDIVEDRRRR---NISGDDMLQALMDATYKDGR-KLSEN 259 Query 245 EITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQI 304 EITG+ +++MFAGHHTS T SW I L +H + A + E E+ GD ++ LR + Sbjct 260 EITGLLLTIMFAGHHTSGVTFSWMGILLAQHPEWVAELRQEQAEVRGDRAELTLEDLRAM 319 Query 305 PQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHD 364 P+LE +KE LR++PP+I++MR +FE G+RI G ++ ASPA+S+ IPE FP+P Sbjct 320 PKLEATIKEVLRMYPPIIVVMRKVVNDFEFGGYRIPHGTMLFASPAVSHYIPELFPEPTR 379 Query 365 FVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPE 424 F P R+ P D + W+PFGAGRHRC+G FA +Q++A++S LLR ++FE Q E Sbjct 380 FDPTRFLAPTSADKKHPMGWLPFGAGRHRCMGIMFAQLQLRALWSHLLRNFDFETVQ-GE 438 Query 425 SYRNDHSKMVVQLAQPACVRYRRRT 449 Y D+++++V P +RYRRR+ Sbjct 439 VYEPDYARLLVGPRHPCRLRYRRRS 463 >gi|297844012|ref|XP_002889887.1| CYP51G1 [Arabidopsis lyrata subsp. lyrata] gi|297335729|gb|EFH66146.1| CYP51G1 [Arabidopsis lyrata subsp. lyrata] Length=488 Score = 297 bits (761), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 171/442 (39%), Positives = 249/442 (57%), Gaps = 17/442 (3%) Query 17 GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76 G L +F PI +++ + G V T L K++ L G + FF+A + DL Q + Y Sbjct 51 GSLIKFLKGPIVMLREEYPKLGSVFTVNLLHKKITFLIGPEVSAHFFKASESDLSQQEVY 110 Query 77 PFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRRMIADWGEAGEI 134 F P FG GVVFD R+E ALR ++KG+ + + + WGE+GE+ Sbjct 111 QFNVPTFGPGVVFDVDYSVRQEQFRFFTEALRVTKLKGYVDMMVTEAEDYFSKWGESGEV 170 Query 135 DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR 194 DL L I T+S CL+G++ RDQL + L+H+L+ G P++ + PYLPI + RRR Sbjct 171 DLKVELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPIPAHRRR 230 Query 195 DEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMM 254 D AR L + + I+ R + KS+ DML I K + G + + E+TG+ I+ + Sbjct 231 DRAREKLAEIFSKIIGSR---KRSGKSENDMLQCFIESKYKDGR-QTTESEVTGLLIAAL 286 Query 255 FAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHALRQIPQLENVLKE 313 FAG HTSS T++WT LMR+++ ++A +DE L G + L ++ L +KE Sbjct 287 FAGQHTSSITSTWTGAYLMRYKEYFSAALDEQKNLIAKHGDKIDHDILSEMDVLYRCIKE 346 Query 314 TLRLHPPLIILMRVAKGEFEV-----QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPA 368 LRLHPPLI+LMR + +F V + + I +G +VA SPA +NR+P F DP + P Sbjct 347 ALRLHPPLIMLMRASHSDFSVTARDGKTYDIPKGHIVATSPAFANRLPHIFKDPDTYDPE 406 Query 369 RYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQP-PESY 426 RY R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E E+ P PE Sbjct 407 RYSPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPEI- 465 Query 427 RNDHSKMVVQLAQPACVRYRRR 448 D + MVV + VRY+RR Sbjct 466 --DWNAMVVGVKGNVMVRYKRR 485 >gi|224072463|ref|XP_002303744.1| cytochrome P450 probable obtusifoliol 14-alpha-demethylase [Populus trichocarpa] gi|222841176|gb|EEE78723.1| cytochrome P450 probable obtusifoliol 14-alpha-demethylase [Populus trichocarpa] Length=488 Score = 295 bits (756), Expect = 9e-78, Method: Compositional matrix adjust. Identities = 174/453 (39%), Positives = 253/453 (56%), Gaps = 17/453 (3%) Query 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 LP V G G L F PI +++ + G V T LA ++ L G + FF+A Sbjct 38 LPPVMKGWPLIGGLIRFLKGPIVMLREEYPKLGSVFTVNLANWKITFLIGPEVSAHFFKA 97 Query 66 GDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRR 123 + DL Q + Y F P FG GVVFD R+E +LR ++KG+ + + Sbjct 98 SEADLSQQEVYQFNVPTFGPGVVFDVDYSIRQEQFRFFTESLRVSKLKGYVDQMVVEAED 157 Query 124 MIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVD 183 + WG++G +D+ L I T+S CL+G++ RD+L + L+H+L+ G P++ + Sbjct 158 YFSKWGDSGVVDIKYELEHLIILTASRCLLGREVRDKLFDDVSALFHDLDNGMLPISVLF 217 Query 184 PYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSA 243 PYLPI + RRRD AR L + A+I+N R KS+ DML I K + G P + Sbjct 218 PYLPIPAHRRRDRARKKLAEIFANIINSR---KLAGKSENDMLQCFIDSKYKDGRPT-TE 273 Query 244 DEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHALR 302 EITG+ I+ +FAG HTSS T++WT L+RH + +AV++E L G V L Sbjct 274 SEITGLLIAALFAGQHTSSITSTWTGAYLLRHNEYLSAVLEEQKNLMKKHGNKVDQDILS 333 Query 303 QIPQLENVLKETLRLHPPLIILMRVAKGEFEV-----QGHRIHEGDLVAASPAISNRIPE 357 ++ L +KE LRLHPPLI+L+R + +F V + + I +G +VA SPA +NR+P Sbjct 334 EMGVLHRCIKEALRLHPPLIMLLRSSHSDFSVTTRDGKEYDIPKGHIVATSPAFANRLPH 393 Query 358 DFPDPHDFVPARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYE 416 F DP + P R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E Sbjct 394 VFKDPERYDPDRFAAGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFE 453 Query 417 FEMAQP-PESYRNDHSKMVVQLAQPACVRYRRR 448 FE+ P PE+ D + MVV + VRY+RR Sbjct 454 FELISPFPET---DWNAMVVGVKDKVMVRYKRR 483 >gi|224057852|ref|XP_002299356.1| cytochrome P450 obtusifoliol 14-alpha-demethylase [Populus trichocarpa] gi|222846614|gb|EEE84161.1| cytochrome P450 obtusifoliol 14-alpha-demethylase [Populus trichocarpa] Length=488 Score = 295 bits (754), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 175/453 (39%), Positives = 250/453 (56%), Gaps = 17/453 (3%) Query 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 LP V G G L F PI +++ + G V T L +++ L G + FF+A Sbjct 38 LPPVMKGWPLIGGLIRFLKGPIVMLREEYPKLGSVFTVNLVNRKITFLIGPEVSAHFFKA 97 Query 66 GDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRR 123 + DL Q + Y F P FG GVVFD R+E ALR ++KG+ + + Sbjct 98 SEVDLSQQEVYQFNVPTFGPGVVFDVEYSIRQEQFRFFTEALRVNKLKGYVDQMVVEAED 157 Query 124 MIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVD 183 WG++G +DL L I T+S CL+G++ RD+L A L+H+L+ G P++ + Sbjct 158 YFLKWGDSGVVDLKYELEHLIILTASRCLLGREVRDKLFDDVAALFHDLDNGMLPVSVLF 217 Query 184 PYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSA 243 PYLPI + RRRD AR L + A+I+N R KS+ DML I K + G P + Sbjct 218 PYLPIPAHRRRDRARKKLAEIFANIINSR---KLASKSENDMLQCFIDSKYKDGRPT-TE 273 Query 244 DEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHALR 302 EITG+ I+ +FAG HTSS T++WT L+RH + +AV++E L G V L Sbjct 274 SEITGLLIAALFAGQHTSSITSTWTGAYLLRHNEYLSAVLEEQKNLMKKHGNKVDHDILS 333 Query 303 QIPQLENVLKETLRLHPPLIILMRVAKGEFEV-----QGHRIHEGDLVAASPAISNRIPE 357 ++ L +KE LRLHPPLI+L+R + +F V + + I +G +VA SPA +NR+P Sbjct 334 EMDVLYRCIKEALRLHPPLIMLLRSSHSDFSVTTRDGKEYDIPKGHIVATSPAFANRLPH 393 Query 358 DFPDPHDFVPARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYE 416 F DP + P R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E Sbjct 394 VFKDPDSYDPDRFAYGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFE 453 Query 417 FEMAQP-PESYRNDHSKMVVQLAQPACVRYRRR 448 E+ P PE D + MVV + VRY+RR Sbjct 454 LELISPFPEI---DWNAMVVGVKDKVMVRYKRR 483 >gi|15221075|ref|NP_172633.1| cytochrome P450, family 51 (sterol 14-demethylase) [Arabidopsis thaliana] gi|4835788|gb|AAD30254.1|AC007296_15 Strong similarity to gb|U74319 obtusifoliol 14-alpha demethylase (CYP51) from Sorghum bicolor and is a member of the PF|00067 cytochrome P450 family. ESTs gb|AA72030, gb|N65031 and gb|AA651059 come from this gene [Arabidopsis thaliana] gi|15294294|gb|AAK95324.1|AF410338_1 At1g11680/F25C20_17 [Arabidopsis thaliana] gi|14624983|dbj|BAB61873.1| obtusifoliol 14-demethylase [Arabidopsis thaliana] gi|15292853|gb|AAK92797.1| putative obtusifoliol 14-alpha demethylase [Arabidopsis thaliana] gi|20258897|gb|AAM14142.1| putative obtusifoliol 14-alpha demethylase [Arabidopsis thaliana] gi|21536753|gb|AAM61085.1| putative obtusifoliol 14-alpha demethylase [Arabidopsis thaliana] gi|332190648|gb|AEE28769.1| cytochrome P450, family 51 (sterol 14-demethylase) [Arabidopsis thaliana] Length=488 Score = 295 bits (754), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 169/442 (39%), Positives = 249/442 (57%), Gaps = 17/442 (3%) Query 17 GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76 G L +F PI +++ + G V T L K++ L G + FF+A + DL Q + Y Sbjct 51 GSLIKFLKGPIIMLREEYPKLGSVFTVNLVHKKITFLIGPEVSAHFFKASESDLSQQEVY 110 Query 77 PFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRRMIADWGEAGEI 134 F P FG GVVFD R+E ALR ++KG+ + + + WGE+GE+ Sbjct 111 QFNVPTFGPGVVFDVDYSVRQEQFRFFTEALRVNKLKGYVDMMVTEAEDYFSKWGESGEV 170 Query 135 DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR 194 D+ L I T+S CL+G++ RDQL + L+H+L+ G P++ + PYLPI + RRR Sbjct 171 DIKVELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPIPAHRRR 230 Query 195 DEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMM 254 D AR L + A I+ R + K++ DML I K + G + + E+TG+ I+ + Sbjct 231 DRAREKLSEIFAKIIGSR---KRSGKTENDMLQCFIESKYKDGR-QTTESEVTGLLIAAL 286 Query 255 FAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHALRQIPQLENVLKE 313 FAG HTSS T++WT LMR+++ ++A +DE L G + L ++ L +KE Sbjct 287 FAGQHTSSITSTWTGAYLMRYKEYFSAALDEQKNLIAKHGDKIDHDILSEMDVLYRCIKE 346 Query 314 TLRLHPPLIILMRVAKGEFEV-----QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPA 368 LRLHPPLI+LMR + +F V + + I +G +VA SPA +NR+P F DP + P Sbjct 347 ALRLHPPLIMLMRASHSDFSVTARDGKTYDIPKGHIVATSPAFANRLPHIFKDPDTYDPE 406 Query 369 RYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQP-PESY 426 R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E E+ P PE Sbjct 407 RFSPGREEDKAAGAFSYIAFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPEI- 465 Query 427 RNDHSKMVVQLAQPACVRYRRR 448 D + MVV + VRY+RR Sbjct 466 --DWNAMVVGVKGNVMVRYKRR 485 >gi|224000301|ref|XP_002289823.1| obtusifoliol 14-alpha demethylase [Thalassiosira pseudonana CCMP1335] gi|220975031|gb|EED93360.1| obtusifoliol 14-alpha demethylase [Thalassiosira pseudonana CCMP1335] Length=445 Score = 293 bits (749), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 163/443 (37%), Positives = 258/443 (59%), Gaps = 14/443 (3%) Query 17 GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76 G + EF P+ ++QR ++ G V T K++ L G A E FF+A D+ L Q + Y Sbjct 5 GTIVEFGKSPVKMVQRCYEDYGPVFTVPFFHKRLTFLIGPEAQEPFFKAPDEVLSQNEVY 64 Query 77 PFMTPIFGEGVVFDASPERRKEMLHNAA--LRGEQMKGHAATIEDQVRRMIADWGEAGEI 134 FM P+FG G+V+DAS + R+ + A LR ++KG+ A IE + R+ + WGE+GE+ Sbjct 65 GFMKPVFGPGIVYDASKKNRQVQFQSMANGLRTARLKGYTAKIERETRQYLESWGESGEL 124 Query 135 DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR 194 DL +ELTI T+S CL G R+ L ++LYH+L++G PL P P +S +R Sbjct 125 DLFHALSELTILTASRCLHGDDVRENLFKEVSELYHDLDQGLTPLTVFFPNAPTKSHMKR 184 Query 195 DEARNGLVALVADIMNGRIANPPTDKSD-RDMLDVLIAVKAETGTPRFSADEITGMFISM 253 + AR +V L + ++ R NP SD D+L + + VK + G+ + +++TG+ I++ Sbjct 185 NAARAKMVELFSKVIKNRRDNPDVQHSDGTDILSIFMDVKYKDGS-NITDEQVTGLLIAL 243 Query 254 MFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD--GRSVSFHALRQ-IPQLENV 310 +FAG HTS T++WT + ++ + +I E ++++G V + + + +P L N Sbjct 244 LFAGQHTSCITSTWTSLFILNNPAILKRIIAEQNDVFGSQPDADVDYKMVNEDMPLLHNS 303 Query 311 LKETLRLHPPLIILMRVAKGEFEVQG----HRIHEGDLVAASPAISNRIPEDFPDPHDFV 366 +KE LRL PPLI+L+R A + +V+ + I +GD+V SP++ RIPE F +P+ F Sbjct 304 MKEALRLCPPLILLIRYALKDVKVKAAGKDYTIPKGDMVLISPSVGMRIPEVFKEPNTFD 363 Query 367 PARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESY 426 P R+ R+ED + + ++ FG G H C+G FA +Q+K I SVL RE+E EM E+ Sbjct 364 PDRFGPDREEDKSSPFAYMGFGGGMHSCMGQNFAFVQVKTILSVLFREFELEMVS--ETM 421 Query 427 RN-DHSKMVVQLAQPACVRYRRR 448 + D+ MVV VRY+RR Sbjct 422 PDIDYEAMVVGPKGDCRVRYKRR 444 >gi|299735181|gb|ADJ37071.1| obtusifoliol 14alpha-demethylase [Solanum lycopersicum] Length=487 Score = 291 bits (745), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 172/453 (38%), Positives = 250/453 (56%), Gaps = 17/453 (3%) Query 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 LP V G L F P+ ++++ + G V T L K + G + FF+A Sbjct 37 LPPVVKAWPIVGGLIRFLKGPVVMLRQEYPKLGSVFTLNLLNKNITFFIGPEVSAHFFKA 96 Query 66 GDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRR 123 + DL Q + Y F P FG GVVFD R+E ALR ++KG+ + + Sbjct 97 PETDLSQQEVYQFNVPTFGPGVVFDVDYTIRQEQFRFFTEALRVTKLKGYVDQMVTEAEE 156 Query 124 MIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVD 183 + WGE+GE+DL L I T+S CL+G++ R++L + L+H+L+ G P++ + Sbjct 157 YFSKWGESGEVDLKYELEHLIILTASRCLLGEEVRNKLFDDVSALFHDLDNGMLPISVIF 216 Query 184 PYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSA 243 PYLPI + RRRD AR L + A+I+N R T K++ DML I K + G P + Sbjct 217 PYLPIPAHRRRDNARKKLAEIFANIINSR---KRTGKAENDMLQCFIDSKYKDGRPT-TE 272 Query 244 DEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHALR 302 EITG+ I+ +FAG HTSS T++WT L+ + +AV+DE L G V L Sbjct 273 GEITGLLIAALFAGQHTSSITSTWTGSYLLTNDKYMSAVVDEQKNLMKKHGNKVDHDILS 332 Query 303 QIPQLENVLKETLRLHPPLIILMRVAKGEFEV-----QGHRIHEGDLVAASPAISNRIPE 357 ++ L +KE LRLHPPLI+L+R + EF V + + I +G +VA SPA +NR+P Sbjct 333 EMEVLYRCIKEALRLHPPLIMLLRSSHSEFSVTTREGKEYDISKGHIVATSPAFANRLPH 392 Query 358 DFPDPHDFVPARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYE 416 F +P + P R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E Sbjct 393 IFKNPDTYDPDRFGPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFE 452 Query 417 FEMAQP-PESYRNDHSKMVVQLAQPACVRYRRR 448 FE+ P PE D + MVV + V+Y+RR Sbjct 453 FELISPFPEI---DWNAMVVGVKGEVMVKYKRR 482 >gi|47156870|gb|AAT12274.1| obtusifoliol 14alpha-demethylase [Solanum chacoense] Length=487 Score = 291 bits (744), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 173/454 (39%), Positives = 251/454 (56%), Gaps = 24/454 (5%) Query 5 ALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFR 64 ALP V G L F PI ++++ + G V T L K + G + FF+ Sbjct 43 ALPIVGG-------LIRFLKGPIVMLRQEYPKLGSVFTLNLLNKNITFFIGPEVSAHFFK 95 Query 65 AGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVR 122 A + DL Q + Y F P FG GVVFD R+E ALR ++KG+ + + Sbjct 96 APETDLSQQEVYQFNVPTFGPGVVFDVDYTIRQEQFRFFTEALRVTKLKGYVDQMVTEAE 155 Query 123 RMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYV 182 + WGE+GE+DL L I T+S CL+G++ R++L + L+H+L+ G P++ + Sbjct 156 EYFSKWGESGEVDLKYELEHLIILTASRCLLGEEVRNKLFDDVSALFHDLDNGMLPISVI 215 Query 183 DPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFS 242 PYLPI + RRRD AR L + A+I+N R T K++ DML I K + G P + Sbjct 216 FPYLPIPAHRRRDNARKKLAEIFANIINSR---KRTGKAENDMLQCFIDSKYKDGRPT-T 271 Query 243 ADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHAL 301 EITG+ I+ +FAG HTSS T++WT L+ + +AV+DE L G V L Sbjct 272 EGEITGLLIAALFAGQHTSSITSTWTGSYLLTNNKYMSAVVDEQKNLMKKHGNKVDHDIL 331 Query 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEV-----QGHRIHEGDLVAASPAISNRIP 356 ++ L +KE LRLHPPLI+L+R + +F V + + I +G +VA SPA +NR+P Sbjct 332 SEMDVLYRCIKEALRLHPPLIMLLRSSHSDFSVTTREGKEYDIPKGHIVATSPAFANRLP 391 Query 357 EDFPDPHDFVPARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREY 415 F +P + P R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR + Sbjct 392 HIFKNPESYDPDRFGPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNF 451 Query 416 EFEMAQP-PESYRNDHSKMVVQLAQPACVRYRRR 448 EFE+ P PE D + MVV + V+Y+RR Sbjct 452 EFELISPFPEI---DWNAMVVGVKGEVMVKYKRR 482 >gi|189503705|gb|ACE06982.1| obtusifoliol-14alpha-demethylase [Gossypium hirsutum] Length=486 Score = 286 bits (733), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 169/442 (39%), Positives = 251/442 (57%), Gaps = 17/442 (3%) Query 17 GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76 G L F PI +++ + G V T L K++ L G + FF+A + DL Q + Y Sbjct 47 GGLLRFMKGPIVMLREEYPKLGSVFTLNLFNKKITFLIGPEVSSHFFKASESDLSQQEVY 106 Query 77 PFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRRMIADWGEAGEI 134 F P FG GVVFD R+E ALR ++KG+ + + + WG++GE+ Sbjct 107 QFNVPTFGPGVVFDVDYTIRQEQFRFFTEALRVNKLKGYVDQMVTEAEDYFSKWGDSGEV 166 Query 135 DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR 194 DL L I T+S CL+G++ R++L + L+H+L+ G P++ + PYLPI + RRR Sbjct 167 DLKYELEHLIILTASRCLLGQEVRNKLFDDVSALFHDLDNGMLPISVIFPYLPIPAHRRR 226 Query 195 DEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMM 254 D AR L + A+I+ R + KS+ DML I K + G P A E+TG+ I+ + Sbjct 227 DRARKKLAGIFANIIASRKS---AGKSENDMLQCFIESKYKDGRPTTEA-EVTGLLIAAL 282 Query 255 FAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD-GRSVSFHALRQIPQLENVLKE 313 FAG HTSS T++WT L+RH++ +AVI+E ++ G V L ++ L +KE Sbjct 283 FAGQHTSSITSTWTGAYLLRHKEFLSAVIEEQKQIMQKHGSKVDHDILSEMDTLYRCIKE 342 Query 314 TLRLHPPLIILMRVAKGEFEVQG-----HRIHEGDLVAASPAISNRIPEDFPDPHDFVPA 368 LRLHPPLI+L+R + +F V+ + I +G +VA SPA +NR+P + DP + P Sbjct 343 ALRLHPPLIMLLRSSHSDFSVKTRDGKEYDIPKGHIVATSPAFANRLPYIYKDPDTYDPD 402 Query 369 RYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQP-PESY 426 R+ R+ED + +++I FG GRH C+G FA +QIKAI+S LLR +E E+ P PE Sbjct 403 RFSVGREEDKVAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPEI- 461 Query 427 RNDHSKMVVQLAQPACVRYRRR 448 D + MVV + VRY+RR Sbjct 462 --DWNAMVVGVKGKVMVRYKRR 481 >gi|255543234|ref|XP_002512680.1| cytochrome P450, putative [Ricinus communis] gi|223548641|gb|EEF50132.1| cytochrome P450, putative [Ricinus communis] Length=486 Score = 285 bits (730), Expect = 9e-75, Method: Compositional matrix adjust. Identities = 173/453 (39%), Positives = 256/453 (57%), Gaps = 17/453 (3%) Query 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 LP V G G L F PI +++ + G V T LA K++ G + FF+A Sbjct 36 LPPVVKGLPLVGGLFRFLKGPIIMLRDEYPKLGSVFTVNLAQKKITFFIGPEVSAHFFKA 95 Query 66 GDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRR 123 + DL Q + Y F P FG GVVFD R+E ALR ++KG+ + + + Sbjct 96 PESDLSQQEVYQFNVPTFGPGVVFDVDYSIRQEQFRFFTEALRVHKLKGYVDQMVMEAQD 155 Query 124 MIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVD 183 + WG++GE+DL L I T+S CL+G++ RD+L + L+H+L+ G P++ + Sbjct 156 YFSKWGDSGEVDLKYELEHLIILTASRCLLGREVRDKLFDDVSALFHDLDNGMLPISVLF 215 Query 184 PYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSA 243 PYLPI + RRRD AR L + A+I+ R K++ DML I K + G P A Sbjct 216 PYLPIPAHRRRDRARKKLAEIFANIIASRKL---AGKTENDMLQCFIDSKYKDGRPTTEA 272 Query 244 DEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELY-GDGRSVSFHALR 302 E+TG+ I+ +FAG HTSS T++WT L+R+++ +AV++E L G V L Sbjct 273 -EVTGLLIAALFAGQHTSSITSTWTGAYLLRYKEYLSAVLEEQKTLMEKHGNKVDHDILS 331 Query 303 QIPQLENVLKETLRLHPPLIILMRVAKGEFEVQG-----HRIHEGDLVAASPAISNRIPE 357 ++ L +KE LRLHPPLI+L+R + +F V+ + I +G +VA SPA +NR+P Sbjct 332 EMDVLYRCIKEALRLHPPLIMLLRSSHSDFSVKTRDGKEYDIPKGHIVATSPAFANRLPH 391 Query 358 DFPDPHDFVPARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYE 416 + +P + P RY R+ED + +++I FG GRH C+G FA +QIKAI+S LLR +E Sbjct 392 IYKNPDRYDPDRYSAGREEDKVAGAFSYISFGGGRHGCLGEPFAFLQIKAIWSHLLRNFE 451 Query 417 FEMAQP-PESYRNDHSKMVVQLAQPACVRYRRR 448 FE+ P PE+ D + MVV + VRY+RR Sbjct 452 FELVSPFPET---DWNAMVVGVKGKVMVRYKRR 481 Lambda K H 0.322 0.139 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 936947369512 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40