BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv0927c Length=263 Score E Sequences producing significant alignments: (Bits) Value gi|15608067|ref|NP_215442.1| short chain dehydrogenase [Mycobact... 515 3e-144 gi|289744658|ref|ZP_06504036.1| short chain dehydrogenase [Mycob... 488 4e-136 gi|254819337|ref|ZP_05224338.1| short chain dehydrogenase [Mycob... 458 4e-127 gi|296169685|ref|ZP_06851303.1| 7-alpha-hydroxysteroid dehydroge... 456 1e-126 gi|183984550|ref|YP_001852841.1| short-chain type dehydrogenase/... 452 3e-125 gi|118466704|ref|YP_880301.1| short chain dehydrogenase [Mycobac... 451 4e-125 gi|336461313|gb|EGO40185.1| dehydrogenase of unknown specificity... 450 1e-124 gi|41406969|ref|NP_959805.1| short chain dehydrogenase [Mycobact... 447 5e-124 gi|118619563|ref|YP_907895.1| short chain dehydrogenase [Mycobac... 446 1e-123 gi|240171934|ref|ZP_04750593.1| short chain dehydrogenase [Mycob... 445 3e-123 gi|308397509|ref|ZP_07669371.1| short-chain type dehydrogenase/r... 432 3e-119 gi|342860532|ref|ZP_08717183.1| short chain dehydrogenase [Mycob... 430 1e-118 gi|118472040|ref|YP_889819.1| short chain dehydrogenase [Mycobac... 413 1e-113 gi|145222415|ref|YP_001133093.1| short chain dehydrogenase [Myco... 404 8e-111 gi|333989516|ref|YP_004522130.1| short-chain dehydrogenase [Myco... 402 3e-110 gi|108801326|ref|YP_641523.1| short chain dehydrogenase [Mycobac... 399 3e-109 gi|120405871|ref|YP_955700.1| short chain dehydrogenase [Mycobac... 395 3e-108 gi|54024436|ref|YP_118678.1| short chain dehydrogenase [Nocardia... 352 2e-95 gi|262204386|ref|YP_003275594.1| short-chain dehydrogenase/reduc... 340 1e-91 gi|169631706|ref|YP_001705355.1| short chain dehydrogenase [Myco... 337 1e-90 gi|343925440|ref|ZP_08764960.1| putative oxidoreductase [Gordoni... 318 4e-85 gi|311744308|ref|ZP_07718112.1| possible 7-alpha-hydroxysteroid ... 305 3e-81 gi|300784213|ref|YP_003764504.1| 7-alpha-hydroxysteroid dehydrog... 304 8e-81 gi|326331175|ref|ZP_08197471.1| 3-oxoacyl-(acyl-carrier-protein)... 303 2e-80 gi|119714691|ref|YP_921656.1| short chain dehydrogenase [Nocardi... 294 1e-77 gi|326382320|ref|ZP_08204012.1| short chain dehydrogenase [Gordo... 273 2e-71 gi|301631819|ref|XP_002944992.1| PREDICTED: 7-alpha-hydroxystero... 214 8e-54 gi|264677446|ref|YP_003277352.1| short-chain dehydrogenase/reduc... 203 2e-50 gi|254818475|ref|ZP_05223476.1| short chain dehydrogenase [Mycob... 202 3e-50 gi|77361052|ref|YP_340627.1| short chain dehydrogenase [Pseudoal... 202 5e-50 gi|221068350|ref|ZP_03544455.1| short-chain dehydrogenase/reduct... 198 6e-49 gi|299534178|ref|ZP_07047529.1| short chain dehydrogenase [Comam... 196 3e-48 gi|254481286|ref|ZP_05094531.1| oxidoreductase, short chain dehy... 191 9e-47 gi|329897255|ref|ZP_08271994.1| short chain dehydrogenase [gamma... 179 4e-43 gi|254822262|ref|ZP_05227263.1| short-chain dehydrogenase/reduct... 178 7e-43 gi|254774635|ref|ZP_05216151.1| short-chain dehydrogenase/reduct... 177 2e-42 gi|307592002|ref|YP_003899593.1| short-chain dehydrogenase/reduc... 169 3e-40 gi|172037506|ref|YP_001804007.1| 7-alpha-hydroxysteroid dehydrog... 168 6e-40 gi|145222366|ref|YP_001133044.1| short-chain dehydrogenase/reduc... 167 1e-39 gi|218437231|ref|YP_002375560.1| 7-alpha-hydroxysteroid dehydrog... 167 1e-39 gi|337763526|emb|CCB72234.1| Short-chain dehydrogenase/reductase... 167 2e-39 gi|119504176|ref|ZP_01626257.1| short chain dehydrogenase [marin... 166 3e-39 gi|262274839|ref|ZP_06052650.1| 7-alpha-hydroxysteroid dehydroge... 166 3e-39 gi|40062883|gb|AAR37754.1| 7-alpha-hydroxysteroid dehydrogenase,... 166 3e-39 gi|315442800|ref|YP_004075679.1| hypothetical protein Mspyr1_116... 166 4e-39 gi|334133463|ref|ZP_08507015.1| gluconate 5-dehydrogenase [Paeni... 166 4e-39 gi|120405920|ref|YP_955749.1| short-chain dehydrogenase/reductas... 164 1e-38 gi|296165123|ref|ZP_06847674.1| 7-alpha-hydroxysteroid dehydroge... 163 2e-38 gi|342859753|ref|ZP_08716406.1| short chain dehydrogenase [Mycob... 160 1e-37 gi|222529148|ref|YP_002573030.1| 3-oxoacyl-(acyl-carrier-protein... 160 2e-37 >gi|15608067|ref|NP_215442.1| short chain dehydrogenase [Mycobacterium tuberculosis H37Rv] gi|15840350|ref|NP_335387.1| short chain dehydrogenase [Mycobacterium tuberculosis CDC1551] gi|31792114|ref|NP_854607.1| short chain dehydrogenase [Mycobacterium bovis AF2122/97] 70 more sequence titles Length=263 Score = 515 bits (1326), Expect = 3e-144, Method: Compositional matrix adjust. Identities = 263/263 (100%), Positives = 263/263 (100%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR Sbjct 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG Sbjct 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL Sbjct 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLTFPNLDLPIPDL Sbjct 241 TGKTLEVDGGLTFPNLDLPIPDL 263 >gi|289744658|ref|ZP_06504036.1| short chain dehydrogenase [Mycobacterium tuberculosis 02_1987] gi|289757013|ref|ZP_06516391.1| short chain dehydrogenase [Mycobacterium tuberculosis T85] gi|294996412|ref|ZP_06802103.1| short chain dehydrogenase [Mycobacterium tuberculosis 210] gi|289685186|gb|EFD52674.1| short chain dehydrogenase [Mycobacterium tuberculosis 02_1987] gi|289712577|gb|EFD76589.1| short chain dehydrogenase [Mycobacterium tuberculosis T85] gi|326904851|gb|EGE51784.1| short-chain type dehydrogenase/reductase [Mycobacterium tuberculosis W-148] gi|339293935|gb|AEJ46046.1| short chain dehydrogenase [Mycobacterium tuberculosis CCDC5079] gi|339297574|gb|AEJ49684.1| short chain dehydrogenase [Mycobacterium tuberculosis CCDC5180] Length=262 Score = 488 bits (1256), Expect = 4e-136, Method: Compositional matrix adjust. Identities = 262/263 (99%), Positives = 262/263 (99%), Gaps = 1/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR Sbjct 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG Sbjct 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGG VINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGG-VINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 179 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL Sbjct 180 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 239 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLTFPNLDLPIPDL Sbjct 240 TGKTLEVDGGLTFPNLDLPIPDL 262 >gi|254819337|ref|ZP_05224338.1| short chain dehydrogenase [Mycobacterium intracellulare ATCC 13950] Length=263 Score = 458 bits (1178), Expect = 4e-127, Method: Compositional matrix adjust. Identities = 235/263 (90%), Positives = 253/263 (97%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDDKVAVITG GRGLGAAIALAFA+AGADVLIASRT S+L+AVAEQ+RAAGRR Sbjct 1 MILDRFRLDDKVAVITGAGRGLGAAIALAFAEAGADVLIASRTESQLEAVAEQVRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LAGQAV AFGKLDIVVNNVGGTMPNTLL+TSTKDL DAF FNVG Sbjct 61 AHVVAADLAHPESTAELAGQAVEAFGKLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVG 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGGS+INI+STMGRLA RGFAAYGTAKAAL+HYTRL ALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGSIINITSTMGRLAGRGFAAYGTAKAALSHYTRLTALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+NDELR+PME+ATP+RRLGDPVDIAAAAVYLASPAG+FL Sbjct 181 RIRVNAIAPGSILTSALDVVASNDELRSPMEKATPMRRLGDPVDIAAAAVYLASPAGNFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLTFPNLD+P+PDL Sbjct 241 TGKTLEVDGGLTFPNLDIPVPDL 263 >gi|296169685|ref|ZP_06851303.1| 7-alpha-hydroxysteroid dehydrogenase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295895682|gb|EFG75378.1| 7-alpha-hydroxysteroid dehydrogenase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=263 Score = 456 bits (1174), Expect = 1e-126, Method: Compositional matrix adjust. Identities = 235/263 (90%), Positives = 252/263 (96%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDDKVAVITG GRGLGAAIALAFA+AGADVLIASRT S+L+ VAEQ+RAAGRR Sbjct 1 MILDRFRLDDKVAVITGAGRGLGAAIALAFAEAGADVLIASRTESQLEGVAEQVRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TAQLAGQAV AFGKLDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHVVAADLAHPEATAQLAGQAVEAFGKLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGG++INI+STMGRLA RGFAAYGTAKAAL+HYTRLAALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGNIINITSTMGRLAGRGFAAYGTAKAALSHYTRLAALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+NDELRAPME+ATP+RRLGDPVDIAAAAVYLASPAGSFL Sbjct 181 RIRVNAIAPGSILTSALDVVASNDELRAPMEKATPMRRLGDPVDIAAAAVYLASPAGSFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT+PNLD+P+PDL Sbjct 241 TGKTLEVDGGLTYPNLDIPVPDL 263 >gi|183984550|ref|YP_001852841.1| short-chain type dehydrogenase/reductase [Mycobacterium marinum M] gi|183177876|gb|ACC42986.1| short-chain type dehydrogenase/reductase [Mycobacterium marinum M] Length=263 Score = 452 bits (1162), Expect = 3e-125, Method: Compositional matrix adjust. Identities = 234/263 (89%), Positives = 250/263 (96%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDD+VAVITGGGRGLGAAIALAFA+AGADV+IASRT S+LD VA+ +R+ GRR Sbjct 1 MILDRFRLDDQVAVITGGGRGLGAAIALAFAEAGADVVIASRTQSQLDEVADTVRSIGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LAGQAV AFG+LDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHVVAADLAHPEATAELAGQAVEAFGRLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGGS+INI+STMGR+A RGFAAYGTAKAALAHYTRLAALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGSIINITSTMGRVAGRGFAAYGTAKAALAHYTRLAALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL Sbjct 181 RIRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT PNLD+P+PDL Sbjct 241 TGKTLEVDGGLTHPNLDIPVPDL 263 >gi|118466704|ref|YP_880301.1| short chain dehydrogenase [Mycobacterium avium 104] gi|254773929|ref|ZP_05215445.1| short chain dehydrogenase [Mycobacterium avium subsp. avium ATCC 25291] gi|118167991|gb|ABK68888.1| short chain dehydrogenase [Mycobacterium avium 104] Length=263 Score = 451 bits (1161), Expect = 4e-125, Method: Compositional matrix adjust. Identities = 231/263 (88%), Positives = 251/263 (96%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDDKVAVITG GRGLGAAIA+AFA+AGADVLIASRT S+L+AVAEQ+RAAGRR Sbjct 1 MILDRFRLDDKVAVITGAGRGLGAAIAVAFAEAGADVLIASRTESQLEAVAEQVRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LAG+AV AFGKLDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHVVAADLAHPESTAELAGRAVEAFGKLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGG++INI+STMGRLA RGFAAYGTAKAAL+HYTRL ALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGNIINITSTMGRLAGRGFAAYGTAKAALSHYTRLTALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+NDELRAPME+ATPLRRLGDPVDIA+AAVYLASPAG FL Sbjct 181 RIRVNAIAPGSILTSALDVVASNDELRAPMEKATPLRRLGDPVDIASAAVYLASPAGEFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT+PNLD+P+PDL Sbjct 241 TGKTLEVDGGLTYPNLDIPVPDL 263 >gi|336461313|gb|EGO40185.1| dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein [Mycobacterium avium subsp. paratuberculosis S397] Length=263 Score = 450 bits (1157), Expect = 1e-124, Method: Compositional matrix adjust. Identities = 231/263 (88%), Positives = 250/263 (96%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDDKVAVITG GRGLGAAIA+AFA+AGADVLIASRT S+L+AVAEQ+RAAGRR Sbjct 1 MILDRFRLDDKVAVITGAGRGLGAAIAVAFAEAGADVLIASRTESQLEAVAEQVRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LA +AV AFGKLDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHVVAADLAHPESTAELAARAVEAFGKLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGG++INI+STMGRLA RGFAAYGTAKAAL+HYTRL ALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGNIINITSTMGRLAGRGFAAYGTAKAALSHYTRLTALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+NDELRAPME+ATPLRRLGDPVDIAAAAVYLASPAG FL Sbjct 181 RIRVNAIAPGSILTSALDVVASNDELRAPMEKATPLRRLGDPVDIAAAAVYLASPAGEFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT+PNLD+P+PDL Sbjct 241 TGKTLEVDGGLTYPNLDIPVPDL 263 >gi|41406969|ref|NP_959805.1| short chain dehydrogenase [Mycobacterium avium subsp. paratuberculosis K-10] gi|41395319|gb|AAS03188.1| hypothetical protein MAP_0871c [Mycobacterium avium subsp. paratuberculosis K-10] Length=263 Score = 447 bits (1151), Expect = 5e-124, Method: Compositional matrix adjust. Identities = 230/263 (88%), Positives = 249/263 (95%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDDKVAVITG GRGLGAAIA+AFA+AGADVLIASRT S+L+AVAEQ+RAAGRR Sbjct 1 MILDRFRLDDKVAVITGAGRGLGAAIAVAFAEAGADVLIASRTESQLEAVAEQVRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LA +AV AFGKLDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHVVAADLAHPESTAELAARAVEAFGKLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGG++I I+STMGRLA RGFAAYGTAKAAL+HYTRL ALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGNIIKITSTMGRLAGRGFAAYGTAKAALSHYTRLTALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+NDELRAPME+ATPLRRLGDPVDIAAAAVYLASPAG FL Sbjct 181 RIRVNAIAPGSILTSALDVVASNDELRAPMEKATPLRRLGDPVDIAAAAVYLASPAGEFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT+PNLD+P+PDL Sbjct 241 TGKTLEVDGGLTYPNLDIPVPDL 263 >gi|118619563|ref|YP_907895.1| short chain dehydrogenase [Mycobacterium ulcerans Agy99] gi|118571673|gb|ABL06424.1| short-chain type dehydrogenase/reductase [Mycobacterium ulcerans Agy99] Length=263 Score = 446 bits (1148), Expect = 1e-123, Method: Compositional matrix adjust. Identities = 231/263 (88%), Positives = 247/263 (94%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDD+VAVITGGGRG GAAIALAFA+AGADV+IASRT S+LD VA+ +R+ GRR Sbjct 1 MILDRFRLDDQVAVITGGGRGFGAAIALAFAEAGADVVIASRTQSQLDEVADTVRSIGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LAGQAV AFG+LDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHVVAADLAHPEATAELAGQAVEAFGRLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGG +INI+STMGR+A RGFAAYGTAK ALAHYTRLAALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGGIINITSTMGRVAGRGFAAYGTAKVALAHYTRLAALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL Sbjct 181 RIRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT PNLD+P+PDL Sbjct 241 TGKTLEVDGGLTHPNLDIPVPDL 263 >gi|240171934|ref|ZP_04750593.1| short chain dehydrogenase [Mycobacterium kansasii ATCC 12478] Length=263 Score = 445 bits (1144), Expect = 3e-123, Method: Compositional matrix adjust. Identities = 233/263 (89%), Positives = 248/263 (95%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDD+VAVITGGGRGLGAAIALAFA+AGADV+IASRT S+LD VAE +RA GRR Sbjct 1 MILDRFRLDDQVAVITGGGRGLGAAIALAFAEAGADVVIASRTRSQLDEVAEGVRAIGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLA+PEVTA+LAGQ V AFG+LDIVVNNVGGTMPN LL+TSTKDL DAF FNV Sbjct 61 AHVVAADLANPEVTAELAGQTVEAFGRLDIVVNNVGGTMPNMLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGGS+INI+STMGRLA RGFAAYGTAKAALAHYTRL ALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGSIINITSTMGRLAGRGFAAYGTAKAALAHYTRLTALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVAANDELRAPME+ATPLRRLGDPVDIAAAAVYLASPAGSFL Sbjct 181 RIRVNAIAPGSILTSALDVVAANDELRAPMERATPLRRLGDPVDIAAAAVYLASPAGSFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT PNLDLP+PDL Sbjct 241 TGKTLEVDGGLTHPNLDLPVPDL 263 >gi|308397509|ref|ZP_07669371.1| short-chain type dehydrogenase/reductase [Mycobacterium tuberculosis SUMu012] gi|308366866|gb|EFP55717.1| short-chain type dehydrogenase/reductase [Mycobacterium tuberculosis SUMu012] Length=266 Score = 432 bits (1110), Expect = 3e-119, Method: Compositional matrix adjust. Identities = 222/222 (100%), Positives = 222/222 (100%), Gaps = 0/222 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR Sbjct 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG Sbjct 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP Sbjct 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDP 222 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDP Sbjct 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDP 222 >gi|342860532|ref|ZP_08717183.1| short chain dehydrogenase [Mycobacterium colombiense CECT 3035] gi|342132187|gb|EGT85428.1| short chain dehydrogenase [Mycobacterium colombiense CECT 3035] Length=263 Score = 430 bits (1106), Expect = 1e-118, Method: Compositional matrix adjust. Identities = 231/263 (88%), Positives = 251/263 (96%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDDKVAVITG GRGLGAAIALAFA+AGADVLI+SRT+S+L+AVAEQ+RA GRR Sbjct 1 MILDRFRLDDKVAVITGAGRGLGAAIALAFAEAGADVLISSRTASQLEAVAEQVRAVGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LAG+AV AFGKLDIVVNNVGGTMPNTLL+TSTKDL DAF FNV Sbjct 61 AHIVAADLAHPESTAELAGKAVEAFGKLDIVVNNVGGTMPNTLLTTSTKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT+AAVPLMLEHSGGGS+INI+STMGRLA RGFAAY TAKAALAHYTR +ALDLCP Sbjct 121 TAHALTIAAVPLMLEHSGGGSIINITSTMGRLAGRGFAAYATAKAALAHYTRSSALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+NDELRAPME+ATP+RRLGDPVDIAAAAVYLASPAGSFL Sbjct 181 RIRVNAIAPGSILTSALDVVASNDELRAPMEKATPMRRLGDPVDIAAAAVYLASPAGSFL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLTFPNLD+P+PDL Sbjct 241 TGKTLEVDGGLTFPNLDIPVPDL 263 >gi|118472040|ref|YP_889819.1| short chain dehydrogenase [Mycobacterium smegmatis str. MC2 155] gi|118173327|gb|ABK74223.1| short chain dehydrogenase [Mycobacterium smegmatis str. MC2 155] Length=264 Score = 413 bits (1062), Expect = 1e-113, Method: Compositional matrix adjust. Identities = 215/263 (82%), Positives = 236/263 (90%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 +ILD FRLDDKVAV+TG GRGLGAAIALAFA+AGADV+IA+RT S+LD VA Q+ AGR+ Sbjct 2 LILDRFRLDDKVAVVTGAGRGLGAAIALAFAEAGADVVIAARTQSQLDEVAGQVAGAGRK 61 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH V ADLAHP+ TA+L A+ AFGKLD+VVNNVGGTMP LL+TSTKDL DAF FNV Sbjct 62 AHVVVADLAHPDATAELVQAAIEAFGKLDVVVNNVGGTMPAPLLNTSTKDLRDAFTFNVS 121 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT AAVPLMLEHSGGGS+INI+STMGRLA RGF AYGTAKAALAHYTRLAALDLCP Sbjct 122 TAHALTSAAVPLMLEHSGGGSIINITSTMGRLAGRGFVAYGTAKAALAHYTRLAALDLCP 181 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL+VVA+ND LR PME+ TPLRRLGDP DIAAAAVYLASPAG++L Sbjct 182 RIRVNAIAPGSILTSALDVVASNDALREPMEKVTPLRRLGDPADIAAAAVYLASPAGAYL 241 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLT PNLDLPIPDL Sbjct 242 TGKTLEVDGGLTMPNLDLPIPDL 264 >gi|145222415|ref|YP_001133093.1| short chain dehydrogenase [Mycobacterium gilvum PYR-GCK] gi|315442861|ref|YP_004075740.1| hypothetical protein Mspyr1_12250 [Mycobacterium sp. Spyr1] gi|145214901|gb|ABP44305.1| short-chain dehydrogenase/reductase SDR [Mycobacterium gilvum PYR-GCK] gi|315261164|gb|ADT97905.1| dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein [Mycobacterium sp. Spyr1] Length=263 Score = 404 bits (1038), Expect = 8e-111, Method: Compositional matrix adjust. Identities = 217/263 (83%), Positives = 242/263 (93%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDD+VAV+TG GRGLGAA+ALAFA+AGADVLIA+RT S+L+AVAEQI GRR Sbjct 1 MILDRFRLDDQVAVVTGAGRGLGAAMALAFAEAGADVLIAARTQSQLEAVAEQIAGTGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH V ADLA PE TA LA QAV AFG+LDIVVNNVGGTMPN LL+TSTKD+ DAF FNV Sbjct 61 AHIVVADLARPEDTAGLAAQAVEAFGRLDIVVNNVGGTMPNALLNTSTKDMRDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT AAVPLMLEHSGGGS+INI+STMGR+A RGFAAYGTAKAALAHYTRL+ALDL P Sbjct 121 TAHALTTAAVPLMLEHSGGGSIINITSTMGRVAGRGFAAYGTAKAALAHYTRLSALDLAP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSALE+VA+ND+LR PME+ATP++RLGDP+DIAAAAVYLASPAGS+L Sbjct 181 RIRVNAIAPGSILTSALEIVASNDDLRDPMEKATPMKRLGDPLDIAAAAVYLASPAGSYL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGG+TFPNL+LPIPDL Sbjct 241 TGKTLEVDGGITFPNLELPIPDL 263 >gi|333989516|ref|YP_004522130.1| short-chain dehydrogenase [Mycobacterium sp. JDM601] gi|333485484|gb|AEF34876.1| short-chain type dehydrogenase/reductase [Mycobacterium sp. JDM601] Length=263 Score = 402 bits (1032), Expect = 3e-110, Method: Compositional matrix adjust. Identities = 214/263 (82%), Positives = 239/263 (91%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLD+ VAV+TG GRGLGAAIA+AFA+AGADV+IA+RT S+L+AVAEQ+ + GRR Sbjct 1 MILDRFRLDNSVAVVTGAGRGLGAAIAVAFAEAGADVVIAARTRSQLEAVAEQVESTGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADLAHPE TA+LA +AV AFG+LDIVVNNVGGTMPN LL+TS KDL DA FNV Sbjct 61 AHIVAADLAHPEETAKLAAEAVDAFGRLDIVVNNVGGTMPNMLLATSAKDLKDALTFNVV 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT AA PLMLEH+GGGSVINI+STMGRLA RGFAAYGTAKAALAHYTRLAA+DLCP Sbjct 121 TAHALTTAAAPLMLEHAGGGSVINITSTMGRLAGRGFAAYGTAKAALAHYTRLAAMDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 ++RVN IAPGSILTSAL+VVA+NDELR PME+ TP+RRLGDP DIAAAAVYLASPAGS+L Sbjct 181 KIRVNGIAPGSILTSALDVVASNDELREPMEKVTPMRRLGDPTDIAAAAVYLASPAGSYL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LEVDGG+TFPNLDLPIPDL Sbjct 241 TGKILEVDGGITFPNLDLPIPDL 263 >gi|108801326|ref|YP_641523.1| short chain dehydrogenase [Mycobacterium sp. MCS] gi|119870477|ref|YP_940429.1| short chain dehydrogenase [Mycobacterium sp. KMS] gi|126437307|ref|YP_001072998.1| short chain dehydrogenase [Mycobacterium sp. JLS] gi|108771745|gb|ABG10467.1| short-chain dehydrogenase/reductase SDR [Mycobacterium sp. MCS] gi|119696566|gb|ABL93639.1| short-chain dehydrogenase/reductase SDR [Mycobacterium sp. KMS] gi|126237107|gb|ABO00508.1| short-chain dehydrogenase/reductase SDR [Mycobacterium sp. JLS] Length=263 Score = 399 bits (1024), Expect = 3e-109, Method: Compositional matrix adjust. Identities = 217/263 (83%), Positives = 235/263 (90%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLD +VA +TG GRGLGAAIA+AFA+AGADV+IA+RT S+LD VAE+IRA GRR Sbjct 1 MILDRFRLDGQVATVTGAGRGLGAAIAVAFAEAGADVVIAARTESQLDEVAERIRATGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH V ADLAHPE TA LA AV AFGKLDIVVNNVGGTMP L TS KDL DAF FNV Sbjct 61 AHVVVADLAHPESTAGLAPAAVEAFGKLDIVVNNVGGTMPAALTDTSAKDLKDAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT AAVPLMLEHSGGGSVINI+STMGRLA RGFAAYGTAKAALAHYTRLAALDLCP Sbjct 121 TAHALTTAAVPLMLEHSGGGSVINITSTMGRLAGRGFAAYGTAKAALAHYTRLAALDLCP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSAL++VA+ND+LR PME+ATP+RRLGDP DIAAAAVYLASPA S+L Sbjct 181 RIRVNAIAPGSILTSALDIVASNDDLREPMEKATPMRRLGDPEDIAAAAVYLASPAASYL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGGLTFPNLD+P PDL Sbjct 241 TGKTLEVDGGLTFPNLDMPFPDL 263 >gi|120405871|ref|YP_955700.1| short chain dehydrogenase [Mycobacterium vanbaalenii PYR-1] gi|119958689|gb|ABM15694.1| short-chain dehydrogenase/reductase SDR [Mycobacterium vanbaalenii PYR-1] Length=273 Score = 395 bits (1015), Expect = 3e-108, Method: Compositional matrix adjust. Identities = 220/263 (84%), Positives = 240/263 (92%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 +ILD FRLDD+VAV+TG GRGLGAA+ALAFA+AGADVLIA+RT S+L+ VAEQI GRR Sbjct 11 VILDRFRLDDQVAVVTGAGRGLGAAMALAFAEAGADVLIAARTRSQLEEVAEQIEGTGRR 70 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH V ADLAH E TA LA AV AFG+LDIVVNNVGGTMPN LL+TSTKD+ DAFAFNV Sbjct 71 AHIVVADLAHAEDTAALAAGAVEAFGRLDIVVNNVGGTMPNALLTTSTKDMRDAFAFNVA 130 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT AAVPLMLEHSGGGS+INI+STMGRLA RGFAAYGTAKAALAHYTRL+ALDL P Sbjct 131 TAHALTTAAVPLMLEHSGGGSIINITSTMGRLAGRGFAAYGTAKAALAHYTRLSALDLAP 190 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTSALE+VA NDELR PME+ATPLRRLGDP+DIAAAAVYLASPAGS+L Sbjct 191 RIRVNAIAPGSILTSALEIVADNDELRGPMEKATPLRRLGDPLDIAAAAVYLASPAGSYL 250 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGKTLEVDGG+TFPNLDLPIPDL Sbjct 251 TGKTLEVDGGITFPNLDLPIPDL 273 >gi|54024436|ref|YP_118678.1| short chain dehydrogenase [Nocardia farcinica IFM 10152] gi|54015944|dbj|BAD57314.1| putative short chain dehydrogenase [Nocardia farcinica IFM 10152] Length=263 Score = 352 bits (904), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 181/263 (69%), Positives = 211/263 (81%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FR+ +VAV+TG GRGLG AIA+AFA+AGADVLIA+RT +LD VAEQI AAGR+ Sbjct 1 MILDRFRIAGQVAVVTGAGRGLGRAIAVAFAEAGADVLIAARTKQQLDEVAEQITAAGRQ 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH VAADL+ PE A LA AV FG+LDIVVNNVGG MP+ LL T+ + + +AF FNV Sbjct 61 AHVVAADLSDPETAAGLAEAAVQRFGRLDIVVNNVGGAMPSPLLDTTPQAMIEAFTFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 AHAL AAVP ML + GGS++NI+STMGRL R FAAYGTAKAALAHYT+LAALDL P Sbjct 121 NAHALIRAAVPHMLATADGGSIVNITSTMGRLPGRAFAAYGTAKAALAHYTKLAALDLNP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIAPGSILTS+LEVVA N++LR +E TPL +G+P DIAAAA+YL SPAG +L Sbjct 181 RIRVNAIAPGSILTSSLEVVAGNEQLRTELETKTPLHTIGEPADIAAAALYLVSPAGKYL 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LE DGGL PNL +PIPDL Sbjct 241 TGKVLEPDGGLIQPNLAIPIPDL 263 >gi|262204386|ref|YP_003275594.1| short-chain dehydrogenase/reductase SDR [Gordonia bronchialis DSM 43247] gi|262087733|gb|ACY23701.1| short-chain dehydrogenase/reductase SDR [Gordonia bronchialis DSM 43247] Length=263 Score = 340 bits (871), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 185/263 (71%), Positives = 211/263 (81%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FR+DDKVA+ITG GRGLGAAIALAFA+AGADV+IA+R+ ELD VA Q+ GRR Sbjct 1 MILDRFRIDDKVAIITGAGRGLGAAIALAFAEAGADVVIAARSEFELDNVAGQVAELGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 A V DL++ + A LA AV FG+LDIVVNNVGG MP LL TS + L AF FNV Sbjct 61 AKVVPVDLSNADAAANLAQVAVDEFGRLDIVVNNVGGAMPRALLDTSPEQLTGAFEFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 AHAL A+V ML + GGS+INI+STMGRL R F AYGTAKAALAHYTRLA++DL P Sbjct 121 NAHALVTASVKHMLATADGGSIINITSTMGRLPGRAFVAYGTAKAALAHYTRLASMDLNP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVN IAPGSILTS+LEVVAANDE+R+ +E ATPL RLGDP DIAAAA+YLASPAGS++ Sbjct 181 RIRVNGIAPGSILTSSLEVVAANDEMRSTVEGATPLHRLGDPEDIAAAALYLASPAGSYV 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LEVDGGL PNLDLPIPDL Sbjct 241 TGKILEVDGGLIAPNLDLPIPDL 263 >gi|169631706|ref|YP_001705355.1| short chain dehydrogenase [Mycobacterium abscessus ATCC 19977] gi|169243673|emb|CAM64701.1| Putative short chain dehydrogenase/reductase [Mycobacterium abscessus] Length=263 Score = 337 bits (864), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 185/263 (71%), Positives = 210/263 (80%), Gaps = 1/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD F+LD VAV+TG GRGLGAAIA AFAQAGADVLIASRT S+L VA +++AAGR+ Sbjct 1 MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTESQLREVAAKVQAAGRQ 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 A V ADL+ E +A LA +AV FG+LD+VVNNVGGTMP L T+ DLA+AF+FNV Sbjct 61 AEVVVADLSDTEASAALAQKAVDRFGRLDVVVNNVGGTMPKPFLDTTNDDLAEAFSFNVL 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 + HAL AAVP +L+ S SVINI+STMGRL R F Y TAK ALAHYTR AA+DL P Sbjct 121 SGHALLRAAVPHLLK-SDNASVINITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSP 179 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVN IAPGSILTSALEVVA NDE+R +EQ TPL RLGDP DIAAAAVYLASPAGSFL Sbjct 180 RIRVNGIAPGSILTSALEVVAGNDEMRNTLEQNTPLHRLGDPADIAAAAVYLASPAGSFL 239 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LEVDGGL PNLD+P+PDL Sbjct 240 TGKVLEVDGGLIAPNLDIPLPDL 262 >gi|343925440|ref|ZP_08764960.1| putative oxidoreductase [Gordonia alkanivorans NBRC 16433] gi|343764706|dbj|GAA11886.1| putative oxidoreductase [Gordonia alkanivorans NBRC 16433] Length=263 Score = 318 bits (816), Expect = 4e-85, Method: Compositional matrix adjust. Identities = 174/263 (67%), Positives = 209/263 (80%), Gaps = 0/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FR+DD VAV+TG GRGLGAAIA+AFAQAGADV+IA+R+ +LD VA QI AGRR Sbjct 1 MILDRFRIDDHVAVVTGAGRGLGAAIAVAFAQAGADVVIAARSEFDLDQVAGQIADAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 AH V DL++ + A LA AV FG+LD +VNNVGG MP LL T+ K L DAF FNV Sbjct 61 AHVVPVDLSNADAAAALAQAAVEEFGRLDTIVNNVGGAMPRPLLDTTPKHLVDAFDFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 AHAL VA ML +G GS+INI+S +GR+ R +AAYGTAKAALAHYTR+AA+DL P Sbjct 121 NAHALVVAGAKQMLATTGHGSIINITSAVGRVPGRAYAAYGTAKAALAHYTRIAAMDLNP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 ++RVN IAPG+ILTS+LE+VA NDE+R +E ATP+ RLG+P DIAAAA+YLASPAG+++ Sbjct 181 KIRVNGIAPGAILTSSLEIVAGNDEMRTAVESATPMHRLGEPEDIAAAALYLASPAGAYV 240 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LEVDGG+ PNLDLPIPDL Sbjct 241 TGKILEVDGGIIAPNLDLPIPDL 263 >gi|311744308|ref|ZP_07718112.1| possible 7-alpha-hydroxysteroid dehydrogenase [Aeromicrobium marinum DSM 15272] gi|311312481|gb|EFQ82394.1| possible 7-alpha-hydroxysteroid dehydrogenase [Aeromicrobium marinum DSM 15272] Length=271 Score = 305 bits (782), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 166/263 (64%), Positives = 203/263 (78%), Gaps = 1/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FRLDD+VAV+TG GRG+GAA A+A A+AGA V+IA+RT +L VA++I AAG R Sbjct 1 MILDRFRLDDRVAVVTGAGRGIGAASAIALAEAGASVVIAARTEDQLREVADRIEAAGSR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 A VAADL+ + A LA AV +FG+LD+VVNNVGG+MP T+ L DAF FNV Sbjct 61 AVVVAADLSDTDQVAALAQVAVDSFGRLDVVVNNVGGSMPKEFRRTNVTALEDAFHFNVS 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALT AA+P +L GG SV+NISS MGR++ RG+ AYGTAKAAL+H+TRLA DL P Sbjct 121 TAHALTRAALPHLLAGDGG-SVVNISSVMGRVSGRGYLAYGTAKAALSHWTRLAGRDLAP 179 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 RVRVNAIA GS+ TSALE+V ++ L A ME TPLRR+G+P DIAA V+LASPAG++L Sbjct 180 RVRVNAIAVGSVATSALEIVTGDEGLTAQMEAGTPLRRIGEPEDIAATVVFLASPAGAYL 239 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LEVDGG+ PNLD+ +PDL Sbjct 240 TGKVLEVDGGIDQPNLDMGLPDL 262 >gi|300784213|ref|YP_003764504.1| 7-alpha-hydroxysteroid dehydrogenase [Amycolatopsis mediterranei U32] gi|299793727|gb|ADJ44102.1| 7-alpha-hydroxysteroid dehydrogenase [Amycolatopsis mediterranei U32] gi|340525632|gb|AEK40837.1| short chain dehydrogenase [Amycolatopsis mediterranei S699] Length=261 Score = 304 bits (779), Expect = 8e-81, Method: Compositional matrix adjust. Identities = 168/263 (64%), Positives = 203/263 (78%), Gaps = 2/263 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD F+L D+VAV+TG GRG+GAA A+A A+AGADV+IASRT ++L VA ++ AGRR Sbjct 1 MILDRFKLTDQVAVVTGAGRGIGAATAVALAEAGADVVIASRTEAQLKEVAARVSDAGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 A V DL+ PE A LA AV FG+LD+VVNNVGGT P LL ++ + +AF FNV Sbjct 61 AVPVPVDLSSPEAAAALAATAVSEFGRLDLVVNNVGGTYPRPLLESTVDFMEEAFRFNVA 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TAHALTVAA P ++E GGSV+NISS MGR++ RGFAAYGTAKAALAHYTRLAA DL P Sbjct 121 TAHALTVAAAPSLVET--GGSVVNISSVMGRVSGRGFAAYGTAKAALAHYTRLAAADLAP 178 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 RVRVNAI+ GS+ TSALE+V N EL+ ME ATPLR++G+ DIAA V+LAS AG ++ Sbjct 179 RVRVNAISVGSVATSALEIVVGNPELKEKMESATPLRKIGEAEDIAATVVFLASRAGGYI 238 Query 241 TGKTLEVDGGLTFPNLDLPIPDL 263 TGK LEVDGGL PNL+L +PDL Sbjct 239 TGKILEVDGGLQAPNLELGLPDL 261 >gi|326331175|ref|ZP_08197471.1| 3-oxoacyl-(acyl-carrier-protein) reductase [Nocardioidaceae bacterium Broad-1] gi|325951070|gb|EGD43114.1| 3-oxoacyl-(acyl-carrier-protein) reductase [Nocardioidaceae bacterium Broad-1] Length=267 Score = 303 bits (776), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 169/262 (65%), Positives = 197/262 (76%), Gaps = 1/262 (0%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 IL+ FRL D VAV+TG GRG+GAA A+A A+AGADV+IASRT +L AVAE+I AAGRRA Sbjct 3 ILERFRLTDHVAVVTGAGRGIGAATAVALAEAGADVVIASRTERQLRAVAERIEAAGRRA 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 V ADLA VTA LA +A FG+LDIVVNNVGGT+PNT L T L +AF FNV T Sbjct 63 LVVPADLADTAVTAGLAERAYEEFGRLDIVVNNVGGTIPNTFLDTDESYLEEAFHFNVTT 122 Query 122 AHALTVAAVPLMLEH-SGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 AHALT AAVP M++ G SV++ISS MGR A RG+ AYGTAKAALAH+TRLAA DL P Sbjct 123 AHALTRAAVPYMVKSPDGQQSVVSISSMMGRTAGRGYLAYGTAKAALAHWTRLAATDLAP 182 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVN I GS+LTSALE VA ++ +R +E TPLRR+G+ DIAAA VYL S AG F+ Sbjct 183 RIRVNGIFVGSVLTSALEFVAGDETMRGEIEAKTPLRRIGEAEDIAAAVVYLTSRAGQFV 242 Query 241 TGKTLEVDGGLTFPNLDLPIPD 262 TGK LEVDGG P LDL +PD Sbjct 243 TGKLLEVDGGTEAPTLDLKLPD 264 >gi|119714691|ref|YP_921656.1| short chain dehydrogenase [Nocardioides sp. JS614] gi|119535352|gb|ABL79969.1| short-chain dehydrogenase/reductase SDR [Nocardioides sp. JS614] Length=270 Score = 294 bits (752), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 164/268 (62%), Positives = 195/268 (73%), Gaps = 5/268 (1%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD F + +VA++TG GRGLGAA A+A A+AG+DVLI++RT +LD VAE+IRA GRR Sbjct 1 MILDRFSTEGQVAIVTGAGRGLGAATAVALAEAGSDVLISARTERQLDQVAERIRATGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 A VAADL+ + A LA A G+LD VVNNVGGT PN L TS + L +AFAFNV Sbjct 61 ALVVAADLSDLDAVAGLAQTAYDELGRLDTVVNNVGGTFPNAFLDTSNEFLNEAFAFNVT 120 Query 121 TAHALTVAAVPLMLEHSGG-----GSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAA 175 TAHALT AAVPLML +G SV+ ISS MGR A RGF AYGTAKAALAH+TR+AA Sbjct 121 TAHALTRAAVPLMLRDAGSVADAQKSVVTISSMMGRTADRGFIAYGTAKAALAHWTRMAA 180 Query 176 LDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASP 235 DL PR+RVN I GSI+TSALE VA EL + +E TPL R+G+P DIAA VYLAS Sbjct 181 QDLAPRIRVNGIYVGSIMTSALEYVAGRPELMSQLETKTPLGRVGEPEDIAAGVVYLASR 240 Query 236 AGSFLTGKTLEVDGGLTFPNLDLPIPDL 263 AG ++TGK LE+DGG+ P LDL PD+ Sbjct 241 AGQYVTGKLLEIDGGIQQPTLDLGFPDV 268 >gi|326382320|ref|ZP_08204012.1| short chain dehydrogenase [Gordonia neofelifaecis NRRL B-59395] gi|326199050|gb|EGD56232.1| short chain dehydrogenase [Gordonia neofelifaecis NRRL B-59395] Length=261 Score = 273 bits (697), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 154/253 (61%), Positives = 186/253 (74%), Gaps = 1/253 (0%) Query 11 KVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAH 70 + A++TG GRG+GA IA+ A AGAD+++A+R++ +LD VAEQIRA GRRA TV DLA Sbjct 10 RAAIVTGAGRGIGAGIAIGLADAGADIVLAARSAGQLDEVAEQIRARGRRAVTVPIDLAK 69 Query 71 PEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAV 130 + A L A F +LDIVVNNVGG +P L TS ++L+ AFAFNVGTAHAL +AAV Sbjct 70 DD-PAALVEHASAEFDRLDIVVNNVGGAVPKPFLQTSVEELSGAFAFNVGTAHALNLAAV 128 Query 131 PLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPRVRVNAIAPG 190 P MLE G GS+INI+S++ R F YGT KAALAHYTR+AA DL PR+RVN IAPG Sbjct 129 PKMLERDGTGSIINITSSITSHPGRAFVVYGTVKAALAHYTRMAAQDLSPRIRVNGIAPG 188 Query 191 SILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGG 250 SI T AL+ VAANDE+R M TP+RRLG P DIAAAAV+LAS S+LTGK LEVDGG Sbjct 189 SIHTPALDYVAANDEVRNQMLSRTPMRRLGTPSDIAAAAVFLASDQSSYLTGKILEVDGG 248 Query 251 LTFPNLDLPIPDL 263 L N +P+PDL Sbjct 249 LVSSNFLMPLPDL 261 >gi|301631819|ref|XP_002944992.1| PREDICTED: 7-alpha-hydroxysteroid dehydrogenase-like [Xenopus (Silurana) tropicalis] Length=254 Score = 214 bits (546), Expect = 8e-54, Method: Compositional matrix adjust. Identities = 124/256 (49%), Positives = 161/256 (63%), Gaps = 2/256 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M+L +F L + A++TG G+G+G A ALA AQAGADV +A+RT ++LD VA +I A GR Sbjct 1 MVLKLFSLSSQAAIVTGAGKGIGKACALALAQAGADVALAARTQADLDVVAAEIHALGRH 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 A T+A D+ + V L + V GK+ I++NNVGG+ PN L + + A NV Sbjct 61 AITLAGDINNEAVMDALLTRTVTELGKVTILINNVGGSGPNHPLKMGGAEFSAALIRNVT 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 A+ +T VP M + +GGG+V+NISS R A + F+ YG AKAAL TR A D P Sbjct 121 LAYLMTQKCVPAM-QDAGGGAVVNISSVAARYAQKHFSVYGAAKAALNQLTRNLAQDFGP 179 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 +VRVNAI PG+I+TSAL E M TPL RLG P DIAAA V+LASPA ++ Sbjct 180 QVRVNAIEPGTIMTSALAPF-LTPERAERMLSTTPLARLGQPEDIAAAVVFLASPAAGWI 238 Query 241 TGKTLEVDGGLTFPNL 256 TGK L VDGG+ PN Sbjct 239 TGKILGVDGGVEAPNF 254 >gi|264677446|ref|YP_003277352.1| short-chain dehydrogenase/reductase SDR [Comamonas testosteroni CNB-2] gi|262207958|gb|ACY32056.1| short-chain dehydrogenase/reductase SDR [Comamonas testosteroni CNB-2] Length=256 Score = 203 bits (517), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 119/255 (47%), Positives = 162/255 (64%), Gaps = 2/255 (0%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 I F L+ KVAV+TG G+G+G A A+ A+AGADV + +RT ++L AV +I A GRRA Sbjct 4 IFRQFSLEGKVAVVTGAGKGIGRACAVTLAKAGADVALFARTEADLQAVKAEIEALGRRA 63 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 V D+ E +L + V GK+++++NNVGG PN + K + D AFNV Sbjct 64 IAVQGDVNKEEDLDKLIVRTVEELGKINVLINNVGGGGPNDPRKVAGKAVGDMLAFNVVP 123 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR 181 A+ L + +E +GGG+V+NISST R + + F+AYG AKAAL TR A D PR Sbjct 124 AYTL-IQKAAAAMEAAGGGAVVNISSTAARYSQKYFSAYGAAKAALNQMTRCLAQDFGPR 182 Query 182 VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT 241 VR+NAI PG+I+T AL D + ME+ TP+ R+G P DIA+AA++LASPA S++T Sbjct 183 VRINAIEPGTIMTDALAPFLTPDR-KERMEKTTPMARMGQPEDIASAALFLASPASSWVT 241 Query 242 GKTLEVDGGLTFPNL 256 GK L VDGG+ PN Sbjct 242 GKVLGVDGGVEAPNF 256 >gi|254818475|ref|ZP_05223476.1| short chain dehydrogenase [Mycobacterium intracellulare ATCC 13950] Length=278 Score = 202 bits (515), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 119/259 (46%), Positives = 165/259 (64%), Gaps = 0/259 (0%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD FR++D+VA++TG G G+G AIA+A A+AGA V++A+R+ ++LD QI A GRR Sbjct 1 MILDDFRINDQVAIVTGAGVGIGRAIAIALAEAGAHVVVAARSKADLDETVRQIEATGRR 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 + D+ + A L A+ FGKLDI+VNN GGT P ++TS++ L A FN Sbjct 61 GLAIVTDVMVDDDLANLVRGALAHFGKLDILVNNAGGTQPRPAIATSSRYLGTALHFNAV 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 L+ A M++ G G+++NISS G + F AYG KAAL T+ A D P Sbjct 121 APFVLSKLAAQAMVDTDGAGAIVNISSRSGDMVMTSFLAYGAGKAALNMITQNLAADFAP 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 R+RVNAIA G + T A++ V N +LR + TP+ R+G+P D+AAAA+YLAS A S++ Sbjct 181 RIRVNAIAVGGVATQAMDFVMNNAQLREEYVRNTPMNRIGEPRDVAAAALYLASSAASWV 240 Query 241 TGKTLEVDGGLTFPNLDLP 259 TG L VDGG T P+ D+P Sbjct 241 TGVVLRVDGGTTKPSFDIP 259 >gi|77361052|ref|YP_340627.1| short chain dehydrogenase [Pseudoalteromonas haloplanktis TAC125] gi|76875963|emb|CAI87185.1| 7-alpha-hydroxysteroid dehydrogenase ( 7-alpha-HSDH) [Pseudoalteromonas haloplanktis TAC125] Length=264 Score = 202 bits (513), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 127/261 (49%), Positives = 169/261 (65%), Gaps = 6/261 (2%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 ILD FRLD +VA++TG GRG+GAAIALA A AGAD+++ +RT +++ A QIR G RA Sbjct 3 ILDRFRLDGQVAIVTGSGRGIGAAIALALADAGADIVVTARTIEDIEQTAAQIRQRGSRA 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGT-MPNTLLSTSTKDLADAFAFNVG 120 VA D+ + L + + FG+LDI+VNNVGG+ LS+S +L + F N Sbjct 63 LVVACDVLDEQQRQSLVDKTIEHFGRLDILVNNVGGSGAIKPTLSSSAAELENCFKLNTA 122 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 TA L+ + P M+ SG GS+INISS G+LA GF +YG AKAAL T A D P Sbjct 123 TAFDLSRISAPHMVNTSGQGSIINISSVAGQLAQPGFISYGIAKAALNFMTLNLAQDFAP 182 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 +VRVNAI+ GS LT AL+ V NDE+ + + TP+ RLG P D+AA A++LASPA ++ Sbjct 183 KVRVNAISVGSTLTEALKGV-MNDEMEQAIVKRTPMNRLGQPEDVAACALFLASPAAGYI 241 Query 241 TGKTLEVDGGLTFPNLDLPIP 261 TG+ V+GGLT D P+P Sbjct 242 TGEIFGVNGGLT----DAPMP 258 >gi|221068350|ref|ZP_03544455.1| short-chain dehydrogenase/reductase SDR [Comamonas testosteroni KF-1] gi|220713373|gb|EED68741.1| short-chain dehydrogenase/reductase SDR [Comamonas testosteroni KF-1] Length=256 Score = 198 bits (504), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 115/255 (46%), Positives = 159/255 (63%), Gaps = 2/255 (0%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 I F L+ +VAV+TG G+G+G A A+ A+AGADV + +RT ++L AV +I GRRA Sbjct 4 IFRQFSLEGQVAVVTGAGKGIGRACAITLARAGADVALFARTEADLQAVKAEIEVLGRRA 63 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 V D+ E L + V GK+++++NNVGG PN + K + D AFNV Sbjct 64 IIVPGDVNREEDLQALIDRTVAELGKINVLINNVGGGGPNDPRKVTGKAVGDMLAFNVVP 123 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR 181 A+ L + V ++ +GGG+V+NISST R + + F+AY +KAAL TR A D PR Sbjct 124 AYTL-IQKVAAAMDAAGGGTVVNISSTAARYSQKYFSAYAASKAALNQLTRCLAQDFGPR 182 Query 182 VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT 241 VR+NAI PG+I+T AL E + ME+ TP+ R+G P DIA AA++LASPA S++T Sbjct 183 VRINAIEPGTIMTDALAPF-LTPERKERMEKTTPMARMGQPEDIANAALFLASPASSWVT 241 Query 242 GKTLEVDGGLTFPNL 256 GK L VDGG+ PN Sbjct 242 GKVLGVDGGVEAPNF 256 >gi|299534178|ref|ZP_07047529.1| short chain dehydrogenase [Comamonas testosteroni S44] gi|298717825|gb|EFI58831.1| short chain dehydrogenase [Comamonas testosteroni S44] Length=256 Score = 196 bits (498), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 117/255 (46%), Positives = 159/255 (63%), Gaps = 2/255 (0%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 I F L+ KVAV+TG G+G+G A A+ A+AGADV + +RT ++L AV +I A GRRA Sbjct 4 IFRQFSLEGKVAVVTGAGKGIGRACAVTLAKAGADVALFARTEADLQAVKAEIEALGRRA 63 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 V D+ E +L + V GK+++++NNVGG PN + K + D AFNV Sbjct 64 IAVQGDVNKEEDLDKLIVRTVEELGKINVLINNVGGGGPNDPRKVAGKAVGDMLAFNVVP 123 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR 181 A+ L + +E +GGG+V+NISST R + + F+AYG AKAAL T A D P Sbjct 124 AYTL-IQKAAAAMEAAGGGAVVNISSTAARYSQKYFSAYGAAKAALNQMTCCLAQDFGPW 182 Query 182 VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT 241 VR+NAI PG+I+T AL D + ME+ TP+ R+G P DIA AA++LASPA S++T Sbjct 183 VRINAIEPGTIMTDALAPFLTPDR-KERMEKTTPMARMGQPEDIANAALFLASPASSWVT 241 Query 242 GKTLEVDGGLTFPNL 256 GK L VDGG+ PN Sbjct 242 GKVLGVDGGVEAPNF 256 >gi|254481286|ref|ZP_05094531.1| oxidoreductase, short chain dehydrogenase/reductase family [marine gamma proteobacterium HTCC2148] gi|214038449|gb|EEB79111.1| oxidoreductase, short chain dehydrogenase/reductase family [marine gamma proteobacterium HTCC2148] Length=265 Score = 191 bits (485), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 118/258 (46%), Positives = 161/258 (63%), Gaps = 2/258 (0%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 ++D FRLD KVAVITG G+G+GA IALA A+AGA++++A+RT ++L+ VA++I GR + Sbjct 3 VMDRFRLDGKVAVITGAGKGIGAGIALALAEAGANIVLAARTKADLNRVADEITLLGRES 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 + D+ E A L + FG++DI+VNN GG P +L TS K+ A FNV T Sbjct 63 LVMPTDVLDFEQLASLVEATIARFGRIDILVNNAGGFPPKPMLQTSAKEFEAAMRFNVTT 122 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR 181 A L+ P + E G+++NISS G F+AYGTAK AL+ TR A + PR Sbjct 123 AFELSRLCAPYLAEKQ-DGAILNISSVAGEKPTPCFSAYGTAKGALSLLTRELAQEFAPR 181 Query 182 VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLT 241 +RVNAIA GS T AL V E+ M + TP+ RLG+ DIA AVYL SPA S++T Sbjct 182 IRVNAIAVGSTRTDALNTV-LTQEVEQTMVELTPMGRLGEVEDIALGAVYLCSPAASYVT 240 Query 242 GKTLEVDGGLTFPNLDLP 259 G L ++GGL N+ +P Sbjct 241 GDILGINGGLERLNMQMP 258 >gi|329897255|ref|ZP_08271994.1| short chain dehydrogenase [gamma proteobacterium IMCC3088] gi|328921317|gb|EGG28712.1| short chain dehydrogenase [gamma proteobacterium IMCC3088] Length=268 Score = 179 bits (453), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 104/255 (41%), Positives = 149/255 (59%), Gaps = 7/255 (2%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 MILD F+L K+A+ITG G+G+G I LAFA+ GA V+ +R+ +L+ VA R G Sbjct 1 MILDAFKLTGKIALITGAGKGIGEGITLAFAEMGAHVICVARSQDDLEKVAANAREFGVE 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVG----GTMPNTLLSTSTKDLADAFA 116 A ++ D+ E L Q +GKLDI+VNN G G P T ++ S Sbjct 61 ATAISCDVTKEEQLQALVDQVTERYGKLDILVNNAGAPGKGYGPMTEVTKSR--FEHTLG 118 Query 117 FNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAAL 176 N+ + +ALT +PL L+ + +V+N+SS + + R FAAY AKA + TR+ A Sbjct 119 INLTSVYALTQMCLPL-LKAAESATVVNVSSALAWMVDRNFAAYAAAKAGVNQLTRVMAY 177 Query 177 DLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPA 236 +L P +RVN IAPG++ T A + ND + + PL R+GDP DIA A+YLASPA Sbjct 178 ELAPNIRVNGIAPGAVDTPATNFIKQNDAMHKATTRWIPLNRMGDPKDIALGALYLASPA 237 Query 237 GSFLTGKTLEVDGGL 251 F+TGK +++DGG+ Sbjct 238 SGFITGKIIDIDGGM 252 >gi|254822262|ref|ZP_05227263.1| short-chain dehydrogenase/reductase SDR [Mycobacterium intracellulare ATCC 13950] Length=262 Score = 178 bits (452), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 108/267 (41%), Positives = 154/267 (58%), Gaps = 9/267 (3%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ F+LD +VA++TG GRG+G IA A+AGA ++ +RTSSE++A + I AG Sbjct 1 MALEQFKLDGQVAIVTGAGRGVGEGIAKVLAEAGATIVGTARTSSEVEATVKDIELAGGT 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 + AD + ++ AV FG++DIVVNNVG LS + +L F + V Sbjct 61 GLALTADALKRSDSERVVQTAVDKFGRIDIVVNNVGFATYGPFLSLTDDNLRQTFDYCVT 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 +A ++ AVP ML+ G GS++NISS GR RG Y AK L TR A +L P Sbjct 121 SAFIMSQLAVPHMLK-VGRGSIVNISSGAGRFGIRGLLPYSVAKGGLEALTRAMAQELAP 179 Query 181 RVRVNAIAPGSILT----SALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPA 236 ++RVNAIA G+ +T S+ +++ ++E +++ TPL R+GD D+ +YL S Sbjct 180 KIRVNAIALGAFMTTGLQSSFDLMPGSEE---KLKELTPLHRIGDVADLGRLTLYL-STR 235 Query 237 GSFLTGKTLEVDGGLTFPNLDLPIPDL 263 + T T VDGGL PN LPIPDL Sbjct 236 DCYATNSTFIVDGGLQGPNSSLPIPDL 262 >gi|254774635|ref|ZP_05216151.1| short-chain dehydrogenase/reductase SDR [Mycobacterium avium subsp. avium ATCC 25291] Length=262 Score = 177 bits (449), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 107/267 (41%), Positives = 154/267 (58%), Gaps = 9/267 (3%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ F+LD +VA++TG GRG+G IA A+AGA ++ +RTSSE++A + I AG Sbjct 1 MALEQFKLDGQVAIVTGAGRGVGEGIAKVLAEAGATIVGTARTSSEVEATVKDIELAGGT 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 + AD + ++ AV FG++DI+VNNVG LS + +L F + V Sbjct 61 GLALTADALKRSDSERVVQTAVDKFGRIDILVNNVGFATYGPFLSLTDDNLRQTFDYCVT 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 +A ++ AVP ML+ G GS++NISS GR RG Y AK L TR A +L P Sbjct 121 SAFIMSQLAVPHMLK-VGRGSIVNISSGAGRFGIRGLLPYSVAKGGLEALTRAMAQELAP 179 Query 181 RVRVNAIAPGSILT----SALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPA 236 ++RVNAIA G+ +T S+ +++ ++E +++ TPL R+GD D+ +YL S Sbjct 180 KIRVNAIALGAFMTTGLQSSFDLMPGSEE---KLKELTPLHRIGDVADLGRLTLYL-STR 235 Query 237 GSFLTGKTLEVDGGLTFPNLDLPIPDL 263 + T T VDGGL PN LPIPDL Sbjct 236 DCYATNSTFIVDGGLQGPNSSLPIPDL 262 >gi|307592002|ref|YP_003899593.1| short-chain dehydrogenase/reductase SDR [Cyanothece sp. PCC 7822] gi|306985647|gb|ADN17527.1| short-chain dehydrogenase/reductase SDR [Cyanothece sp. PCC 7822] Length=255 Score = 169 bits (429), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 104/250 (42%), Positives = 149/250 (60%), Gaps = 4/250 (1%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 +LD+F+LD++VA+ITG G G+G AIA FAQAGA V+++ VA+ I+ G +A Sbjct 3 VLDIFKLDNQVAIITGAGAGIGRAIAKLFAQAGAAVVVSDLKQETAAQVAQDIKVTGGQA 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 +VA D+ + L QA+ AFGK+ I+VNN GG P A+ NV + Sbjct 63 ISVACDVTNNNDLENLVKQALAAFGKITILVNNAGGGGPKP-FDMPMDTFIWAYKLNVFS 121 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDL-CP 180 L + P + +GGG+++NISS G +YG++KAA+ H TR A DL Sbjct 122 IFHLCQLSAP-HIAAAGGGAILNISSMAGENKNIRMTSYGSSKAAVNHLTRNMAYDLGAN 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 ++RVNAIAPG+I T AL V E+ M + TPL RLG+P DIA +A++L SPA +++ Sbjct 181 KIRVNAIAPGAIKTDALATV-LTPEIEKAMLKHTPLGRLGEPHDIAYSALFLCSPAAAWV 239 Query 241 TGKTLEVDGG 250 +G+ L V GG Sbjct 240 SGQVLTVSGG 249 >gi|172037506|ref|YP_001804007.1| 7-alpha-hydroxysteroid dehydrogenase [Cyanothece sp. ATCC 51142] gi|171698960|gb|ACB51941.1| short-chain dehydrogenase/reductase SDR [Cyanothece sp. ATCC 51142] Length=255 Score = 168 bits (426), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 110/250 (44%), Positives = 150/250 (60%), Gaps = 4/250 (1%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 +LD F+LDD VA+ITG G G+G IA FAQAGA V+++ + VAE+I++ G +A Sbjct 3 VLDSFKLDDHVAIITGAGAGIGRGIAELFAQAGAAVVVSDLKLETAEIVAEKIKSQGGKA 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 V+ D+ E L + AFGK+ I+VNN GG P A+ NV + Sbjct 63 IAVSCDVTTNEALENLVNSTLTAFGKITILVNNAGGGGPKP-FDMPMDTFIWAYQLNVFS 121 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR 181 L VP +E +GGGS++NISS G A+YG++KAA++H TR A DL P+ Sbjct 122 LFHLCQLCVP-HIEAAGGGSILNISSMSGDNKNSNMASYGSSKAAVSHLTRNIAFDLGPK 180 Query 182 -VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 +RVNAIAPG+I T AL V D + M + TPL RLG+P DIA AA++L SPA S++ Sbjct 181 NIRVNAIAPGAIKTDALASVLTPD-IETAMLKHTPLARLGNPKDIAYAALFLCSPAASWI 239 Query 241 TGKTLEVDGG 250 +G+ L V GG Sbjct 240 SGQVLTVSGG 249 >gi|145222366|ref|YP_001133044.1| short-chain dehydrogenase/reductase SDR [Mycobacterium gilvum PYR-GCK] gi|145214852|gb|ABP44256.1| short-chain dehydrogenase/reductase SDR [Mycobacterium gilvum PYR-GCK] Length=262 Score = 167 bits (423), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 106/266 (40%), Positives = 152/266 (58%), Gaps = 9/266 (3%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ F+LD +VA++TG G+G+G IA A+AGA V+ +RT S++ + + I AAG R Sbjct 1 MALEQFQLDGQVAIVTGAGKGVGQGIARVLAEAGATVIGTARTESDIVSTIDGIEAAGGR 60 Query 61 AHTVAAD-LAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNV 119 V AD ++ P+ ++ G A+ FG++DI++NNVGG+ L + +D F + V Sbjct 61 GVAVVADAMSRPD-GERVVGTAMDRFGRIDILINNVGGSTYARFLDITDEDFRHTFDWCV 119 Query 120 GTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC 179 +A ++ A P M++ +G GS++NISS R R AY AK L TR A +L Sbjct 120 TSAFIMSQLAAPHMID-AGRGSIVNISSGSARFGIRALTAYCVAKGGLEALTRAMAQELA 178 Query 180 PRVRVNAIAPGSILTSALEVVAANDELRAPME---QATPLRRLGDPVDIAAAAVYLASPA 236 P++RVNAIA GS T L+ + D L +E +ATPL RLGD D+ VYL S Sbjct 179 PKIRVNAIALGSFATEGLQ--GSLDLLPGSLEKMKEATPLHRLGDVEDLGRLCVYL-STR 235 Query 237 GSFLTGKTLEVDGGLTFPNLDLPIPD 262 + T VDGG+ N LPIPD Sbjct 236 DCYATNAIFHVDGGIDSNNSPLPIPD 261 >gi|218437231|ref|YP_002375560.1| 7-alpha-hydroxysteroid dehydrogenase [Cyanothece sp. PCC 7424] gi|218169959|gb|ACK68692.1| short-chain dehydrogenase/reductase SDR [Cyanothece sp. PCC 7424] Length=255 Score = 167 bits (423), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 103/250 (42%), Positives = 143/250 (58%), Gaps = 4/250 (1%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 +LD F+LDD+V ++TG G G+G AIA FAQAGA ++++ + VAE I G +A Sbjct 3 VLDTFKLDDQVTIVTGAGAGIGRAIAELFAQAGAAIVVSDLNRETAEQVAENINTKGGKA 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 V D+ A L +A+ AFGK+ I+VNN GG P A+ NV + Sbjct 63 IAVPCDVTDNADLANLVQKALEAFGKITILVNNAGGGGPKP-FDMPLDTFIWAYKLNVFS 121 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDL-CP 180 L P + +GGG+++NISS G +YG++KAA+ H TR A DL Sbjct 122 IFHLCQLCAP-HIAAAGGGAILNISSMAGENKNIRMTSYGSSKAAVNHLTRNMAFDLGAK 180 Query 181 RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 +RVNAIAPG+I T AL V E+ M + TPL+RLG+P DIA AA++L SPA ++ Sbjct 181 NIRVNAIAPGAIKTDALATVLT-PEIEQTMLKHTPLKRLGEPNDIAYAALFLCSPASIWV 239 Query 241 TGKTLEVDGG 250 +G+ L V GG Sbjct 240 SGQVLTVSGG 249 >gi|337763526|emb|CCB72234.1| Short-chain dehydrogenase/reductase SDR [Streptomyces cattleya NRRL 8057] Length=279 Score = 167 bits (423), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 110/265 (42%), Positives = 153/265 (58%), Gaps = 13/265 (4%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQI-RAAGRR 60 + D+FRLDD A+ITG RG+GAAIA AFA++GA V +A+RT + VA +I R+ G Sbjct 3 VTDLFRLDDVRALITGASRGIGAAIAQAFAESGARVALAARTERATEDVAGRIGRSCGTE 62 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMP-----NTLLS----TSTKDL 111 AH VA DLA PEV +L QA A G LD++V+N G +P N +L ++ ++ Sbjct 63 AHRVAGDLADPEVAPRLVDQAAHALGGLDVLVHN-AGVLPTDPQGNPVLKPFARSTPEEW 121 Query 112 ADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYT 171 A N+ AL AA +LE S SV+ +SS G + AYG KAA Sbjct 122 QPVVAVNLAATVALCRAAHRHLLE-SPRPSVLLVSSVAGLIGVPTMEAYGVTKAAQVSLA 180 Query 172 RLAALDLCP-RVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAV 230 R A P R+RVNA+ PG + T VV ++ L + + P+RR DP ++A +AV Sbjct 181 RSLATGWAPQRIRVNALCPGWVRTDMTSVVHGDEALSGHLLRHVPMRRWADPGEVAGSAV 240 Query 231 YLASPAGSFLTGKTLEVDGGLTFPN 255 +L SPA SF+TG+ L +DGGL+ P+ Sbjct 241 FLTSPAASFITGQALVIDGGLSVPH 265 >gi|119504176|ref|ZP_01626257.1| short chain dehydrogenase [marine gamma proteobacterium HTCC2080] gi|119460179|gb|EAW41273.1| short chain dehydrogenase [marine gamma proteobacterium HTCC2080] Length=269 Score = 166 bits (421), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 105/253 (42%), Positives = 144/253 (57%), Gaps = 3/253 (1%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M+ D FRLD K A++TG G+G+GA IA AFA+ GAD+++ +RT S+L+ VA + A G++ Sbjct 1 MLTDFFRLDGKTALVTGAGKGIGARIATAFAEMGADLILLARTESDLEQVARDVEALGQQ 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVG--GTMPNTLLSTSTKDLADAFAFN 118 A D+ A KLDIVVNN G G +L + K N Sbjct 61 ARVFPCDITDEAAIATTFTDLKSELSKLDIVVNNAGAPGKGFGSLAKVTKKRFEHTLDIN 120 Query 119 VGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDL 178 + A+ L A+PL L+ S +++NISS M + R AAY AKA L TR+ A +L Sbjct 121 LSAAYGLIHEALPL-LQASPDAAIVNISSAMSWMVDRHMAAYAAAKAGLDQMTRVLAYEL 179 Query 179 CPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGS 238 P++RVN IAPG+I T A + + + P RLG P DIA AA+YL+S A S Sbjct 180 APKIRVNGIAPGAIETPATAFITQDPGRLEDTVRWIPQGRLGQPTDIALAALYLSSNASS 239 Query 239 FLTGKTLEVDGGL 251 F++GK LEVDGG+ Sbjct 240 FISGKILEVDGGM 252 >gi|262274839|ref|ZP_06052650.1| 7-alpha-hydroxysteroid dehydrogenase [Grimontia hollisae CIP 101886] gi|262221402|gb|EEY72716.1| 7-alpha-hydroxysteroid dehydrogenase [Grimontia hollisae CIP 101886] Length=255 Score = 166 bits (421), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 106/250 (43%), Positives = 144/250 (58%), Gaps = 4/250 (1%) Query 2 ILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRA 61 ILD F L D+VA++TG G+G IA FA+AGA V+++ + VA I A G+ A Sbjct 3 ILDQFSLKDQVAIVTGAAAGIGRRIAEVFAEAGAKVVVSDLNLDAANEVASAINATGQHA 62 Query 62 HTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGT 121 VA ++ + L QA+ AFGK+ I+ NN GG P D A+ NV Sbjct 63 IAVACNVTKEDDRIALVEQAITAFGKVTILANNAGGGGPKP-FDMPMSDFEWAYQLNVFA 121 Query 122 AHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR 181 L P M E +GGG+V+NISS G A+YG++KAA+ H TR A DL + Sbjct 122 PFRLMQLCAPEM-EKAGGGAVLNISSMAGENKNWMMASYGSSKAAVNHLTRNVAFDLGSK 180 Query 182 -VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFL 240 +RVNAIAPG+I T+ALE V E+ + M + TPL RLG DIA AA++L SPA +++ Sbjct 181 GIRVNAIAPGAIRTAALEKV-LTPEIESAMLKHTPLGRLGKTDDIAMAALFLCSPAAAWV 239 Query 241 TGKTLEVDGG 250 +G+ L V GG Sbjct 240 SGQVLTVSGG 249 >gi|40062883|gb|AAR37754.1| 7-alpha-hydroxysteroid dehydrogenase, putative [uncultured marine bacterium 442] Length=269 Score = 166 bits (420), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 104/253 (42%), Positives = 144/253 (57%), Gaps = 3/253 (1%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M+ D FRLD K A++TG G+G+GA IA AFA+ GAD+++ +RT S+L+ VA + A G++ Sbjct 1 MLTDFFRLDGKTALVTGAGKGIGARIATAFAEMGADLILLARTESDLEQVARDVEALGQQ 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVG--GTMPNTLLSTSTKDLADAFAFN 118 A D+ A KLDIV+NN G G +L + K N Sbjct 61 ARVFPCDITDEAAIATTFNDLKSELPKLDIVINNAGAPGKGFGSLAKVTKKRFEHTLDIN 120 Query 119 VGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDL 178 + A+ L A+PL L+ S +++NISS M + R AAY AKA L TR+ A +L Sbjct 121 LSAAYGLIHEALPL-LQASPDAAIVNISSAMSWMVDRHMAAYAAAKAGLDQMTRVLAYEL 179 Query 179 CPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGS 238 P++RVN IAPG+I T A + + + P RLG P DIA AA+YL+S A S Sbjct 180 APKIRVNGIAPGAIETPATAFITQDPGRLEDTVRWIPQGRLGQPTDIALAALYLSSNASS 239 Query 239 FLTGKTLEVDGGL 251 F++GK LEVDGG+ Sbjct 240 FISGKILEVDGGM 252 >gi|315442800|ref|YP_004075679.1| hypothetical protein Mspyr1_11610 [Mycobacterium sp. Spyr1] gi|315261103|gb|ADT97844.1| dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein [Mycobacterium sp. Spyr1] Length=262 Score = 166 bits (420), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 105/266 (40%), Positives = 151/266 (57%), Gaps = 9/266 (3%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ F+LD +VA++TG G+G+G IA A+A A V+ +RT S++ + + I AAG R Sbjct 1 MALEQFQLDGQVAIVTGAGKGVGQGIARVLAEADATVIGTARTESDIVSTIDGIEAAGGR 60 Query 61 AHTVAAD-LAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNV 119 V AD ++ P+ ++ G A+ FG++DI++NNVGG+ L + +D F + V Sbjct 61 GVAVVADAMSRPD-GERVVGTAMDRFGRIDILINNVGGSTYARFLDITDEDFRHTFDWCV 119 Query 120 GTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC 179 +A ++ A P M++ +G GS++NISS R R AY AK L TR A +L Sbjct 120 TSAFIMSQLAAPHMID-AGRGSIVNISSGSARFGIRALTAYCVAKGGLEALTRAMAQELA 178 Query 180 PRVRVNAIAPGSILTSALEVVAANDELRAPME---QATPLRRLGDPVDIAAAAVYLASPA 236 P++RVNAIA GS T L+ + D L +E +ATPL RLGD D+ VYL S Sbjct 179 PKIRVNAIALGSFATEGLQ--GSLDSLPGSLEKMKEATPLHRLGDVEDLGRLCVYL-STR 235 Query 237 GSFLTGKTLEVDGGLTFPNLDLPIPD 262 + T VDGG+ N LPIPD Sbjct 236 DCYATNAIFHVDGGIDSNNSPLPIPD 261 >gi|334133463|ref|ZP_08507015.1| gluconate 5-dehydrogenase [Paenibacillus sp. HGF7] gi|333609020|gb|EGL20300.1| gluconate 5-dehydrogenase [Paenibacillus sp. HGF7] Length=257 Score = 166 bits (419), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 100/255 (40%), Positives = 151/255 (60%), Gaps = 3/255 (1%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQI-RAAGR 59 M L F+L+ K A++TG GRG+G A+A+ A+AGADV++ SRT S+LDAVA +I A GR Sbjct 1 MYLPSFQLEGKTALVTGAGRGIGRALAIGLAEAGADVVLLSRTQSDLDAVAAEIAEATGR 60 Query 60 RAHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNV 119 +A+ +AAD E + G+AV G+LDI+VNN G + L + ++ N+ Sbjct 61 KAYAIAADAGTREGVTEAVGRAVREAGRLDILVNNAGMNIRTPALEVTDEEWDAIVQTNL 120 Query 120 GTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC 179 +A ++ M EH GGG ++N++S G +A R YG+ KAAL T++ AL+ Sbjct 121 KSAFLMSQTVGRHMKEH-GGGRIVNVASVAGHMALRTGVVYGSTKAALIQMTKILALEWA 179 Query 180 PR-VRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGS 238 + VNAI P T E + A++ A + TPL+R+G ++ V+L+S A S Sbjct 180 QYGILVNAIGPWYFPTPLTEKLLADESFVAEVTGRTPLKRVGRLEELVGPVVFLSSDAAS 239 Query 239 FLTGKTLEVDGGLTF 253 ++TG+TL VDGG+T Sbjct 240 YVTGQTLYVDGGMTI 254 >gi|120405920|ref|YP_955749.1| short-chain dehydrogenase/reductase SDR [Mycobacterium vanbaalenii PYR-1] gi|119958738|gb|ABM15743.1| short-chain dehydrogenase/reductase SDR [Mycobacterium vanbaalenii PYR-1] Length=262 Score = 164 bits (416), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 107/266 (41%), Positives = 146/266 (55%), Gaps = 9/266 (3%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ F LD +VAV+TG G+G+G IA A+AGA V+ +RT S++ A I AG + Sbjct 1 MALEQFNLDGQVAVVTGAGKGVGQGIARVLAEAGATVVGTARTESDIVATIAAIERAGGK 60 Query 61 AHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVG 120 + AD ++ AV FG++DI+VNNVGG+ L + D F + V Sbjct 61 GLALVADAMSRADGERVVATAVERFGRIDILVNNVGGSTYARFLDITDDDFRHTFDWCVT 120 Query 121 TAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCP 180 +A ++ A P MLE +G GS+INISS R R AY AK L TR A +L P Sbjct 121 SAFIMSQLAAPHMLE-AGRGSIINISSGSARFGIRALTAYCVAKGGLEALTRAMAQELAP 179 Query 181 RVRVNAIAPGSI----LTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPA 236 ++RVNAIA GS L +L+++ + E M++ATPL RLGD D+ VYLA+ Sbjct 180 KIRVNAIALGSFATEGLQGSLDLLPGSLE---KMKEATPLHRLGDVEDLGRLCVYLATR- 235 Query 237 GSFLTGKTLEVDGGLTFPNLDLPIPD 262 + T VDGG+ N LPIPD Sbjct 236 DCYATNSIFHVDGGIDSNNSPLPIPD 261 >gi|296165123|ref|ZP_06847674.1| 7-alpha-hydroxysteroid dehydrogenase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295899535|gb|EFG78990.1| 7-alpha-hydroxysteroid dehydrogenase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=262 Score = 163 bits (412), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 104/267 (39%), Positives = 151/267 (57%), Gaps = 11/267 (4%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ FRLD +VA++TG G+G+GA IA +AG V+ +RT +++ + E I AAG + Sbjct 1 MALEQFRLDGQVAIVTGAGKGVGAGIARVLGEAGVTVVGTARTEADIVSTIEGIEAAGGK 60 Query 61 AHTVAAD-LAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNV 119 + AD ++ P+ ++ A+ FG++DI+VNNVGG+ L + +D F + V Sbjct 61 GLALVADAMSRPD-GERVVDTAMERFGRIDILVNNVGGSTYARFLDITDEDFRHTFDWCV 119 Query 120 GTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC 179 +A ++ P ML +G GS+INISS R R AY AK L TR A +L Sbjct 120 TSAFIMSQLVAPQMLS-AGRGSIINISSGSARFGIRALTAYCVAKGGLEALTRAMAQELA 178 Query 180 PRVRVNAIAPGSI----LTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASP 235 P++RVNAIA GS L +L+++ + E M++ATPL RLGD D+ AVYL + Sbjct 179 PKIRVNAIALGSFATDGLKGSLDLMPGSLE---KMQEATPLHRLGDVEDLGRLAVYLCT- 234 Query 236 AGSFLTGKTLEVDGGLTFPNLDLPIPD 262 + T VDGG+ N LPIPD Sbjct 235 RDCYATNAVFHVDGGIDSNNSPLPIPD 261 >gi|342859753|ref|ZP_08716406.1| short chain dehydrogenase [Mycobacterium colombiense CECT 3035] gi|342132885|gb|EGT86105.1| short chain dehydrogenase [Mycobacterium colombiense CECT 3035] Length=262 Score = 160 bits (406), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 104/267 (39%), Positives = 151/267 (57%), Gaps = 11/267 (4%) Query 1 MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRR 60 M L+ FRLD +VA++TG G+G+GA IA A+AGA V+ +RT +++ I AAG + Sbjct 1 MALEQFRLDGQVAIVTGAGKGVGAGIARVLAEAGATVVGTARTEADVVGTIAGIEAAGGK 60 Query 61 AHTVAAD-LAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNV 119 + AD ++ P+ + ++ A+ FG++DI+VNNVGG+ L + +D F + V Sbjct 61 GLPLVADAMSRPD-SERVVNTAMERFGRIDILVNNVGGSTYARFLDITDEDFRHTFDWCV 119 Query 120 GTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC 179 +A ++ P ML +G GS++NISS R R AY AK L TR A +L Sbjct 120 TSAFIMSQLVAPHMLA-AGHGSIVNISSGSARFGIRALTAYCVAKGGLEALTRAMAQELA 178 Query 180 PRVRVNAIAPGSI----LTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASP 235 P++RVNAIA GS L +L+++ + E M++ATPL RLGD D+ VYL S Sbjct 179 PKIRVNAIALGSFATDGLRGSLDLMPGSLE---KMQEATPLHRLGDVEDLGRLTVYL-ST 234 Query 236 AGSFLTGKTLEVDGGLTFPNLDLPIPD 262 + T VDGG+ N LPIPD Sbjct 235 RDCYATNAIFHVDGGIDSNNSPLPIPD 261 >gi|222529148|ref|YP_002573030.1| 3-oxoacyl-(acyl-carrier-protein) reductase [Caldicellulosiruptor bescii DSM 6725] gi|222455995|gb|ACM60257.1| 3-oxoacyl-(acyl-carrier-protein) reductase [Caldicellulosiruptor bescii DSM 6725] Length=248 Score = 160 bits (405), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/249 (39%), Positives = 145/249 (59%), Gaps = 5/249 (2%) Query 5 MFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIA-SRTSSELDAVAEQIRAAGRRAHT 63 M L DKVA+ITG RG+G AIAL FAQ GA+V+I S + S+ + + E+I G + Sbjct 1 MELLKDKVALITGASRGIGRAIALKFAQNGANVVINYSSSQSQAENLKEEIEKIGTKTMI 60 Query 64 VAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAH 123 + D+++P+ Q+ Q FG+LDI+VNN G T +L + +D + N+ A Sbjct 61 IKCDVSNPDEVNQMFSQVENEFGRLDILVNNAGITKDGLILRINEEDFDKVISINLKGAF 120 Query 124 ALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-V 182 AA +M++ G++INISS +G G A Y +KA + T+ A +L R + Sbjct 121 LCARAAAKMMVKQR-FGNIINISSVVGIAGNVGQANYAASKAGIIGLTKSLAKELASRNI 179 Query 183 RVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTG 242 RVNAIAPG I T EV++ D+++ M + PL R G+ +IA A++LAS S++TG Sbjct 180 RVNAIAPGFIKTDMTEVLS--DKVKEAMLSSIPLGRFGEADEIANVALFLASSLSSYITG 237 Query 243 KTLEVDGGL 251 + + VDGG+ Sbjct 238 QVIVVDGGM 246 Lambda K H 0.319 0.133 0.371 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 394810015572 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40