BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1079 Length=388 Score E Sequences producing significant alignments: (Bits) Value gi|15608219|ref|NP_215595.1| cystathionine gamma-synthase [Mycob... 783 0.0 gi|254550070|ref|ZP_05140517.1| cystathionine gamma-synthase [My... 783 0.0 gi|240170288|ref|ZP_04748947.1| cystathionine gamma-synthase [My... 699 0.0 gi|15828287|ref|NP_302550.1| cystathionine gamma-synthase [Mycob... 689 0.0 gi|296169943|ref|ZP_06851552.1| cystathionine beta-lyase [Mycoba... 674 0.0 gi|183984359|ref|YP_001852650.1| cystathionine gamma-synthase Me... 669 0.0 gi|118616091|ref|YP_904423.1| cystathionine gamma-synthase [Myco... 667 0.0 gi|325054102|pdb|3QHX|A Chain A, Crystal Structure Of Cystathion... 664 0.0 gi|41407124|ref|NP_959960.1| cystathionine gamma-synthase [Mycob... 659 0.0 gi|254820657|ref|ZP_05225658.1| cystathionine gamma-synthase [My... 657 0.0 gi|342861670|ref|ZP_08718316.1| cystathionine gamma-synthase [My... 652 0.0 gi|120405622|ref|YP_955451.1| cystathionine gamma-synthase [Myco... 636 2e-180 gi|333989665|ref|YP_004522279.1| cystathionine gamma-synthase Me... 635 4e-180 gi|145222634|ref|YP_001133312.1| cystathionine gamma-synthase [M... 634 8e-180 gi|108801110|ref|YP_641307.1| cystathionine gamma-synthase [Myco... 632 3e-179 gi|118467584|ref|YP_889511.1| cystathionine gamma-synthase [Myco... 617 1e-174 gi|169628290|ref|YP_001701939.1| cystathionine gamma-synthase [M... 616 2e-174 gi|312138726|ref|YP_004006062.1| cystathionine beta and gamma-ly... 607 1e-171 gi|325676582|ref|ZP_08156260.1| cystathionine beta-lyase [Rhodoc... 605 3e-171 gi|226365315|ref|YP_002783098.1| cystathionine gamma-synthase [R... 600 1e-169 gi|111022808|ref|YP_705780.1| cystathionine gamma-synthase [Rhod... 600 1e-169 gi|226307752|ref|YP_002767712.1| cystathionine gamma-synthase/cy... 595 6e-168 gi|54026801|ref|YP_121043.1| cystathionine gamma-synthase [Nocar... 594 6e-168 gi|229491930|ref|ZP_04385750.1| cystathionine gamma-synthase [Rh... 593 2e-167 gi|289749611|ref|ZP_06508989.1| cystathionine gamma-synthase met... 589 3e-166 gi|333921085|ref|YP_004494666.1| cystathionine gamma-synthase [A... 587 2e-165 gi|311742688|ref|ZP_07716497.1| cystathionine beta-lyase [Aeromi... 582 3e-164 gi|296140834|ref|YP_003648077.1| cystathionine gamma-synthase [T... 580 1e-163 gi|343925074|ref|ZP_08764606.1| cystathionine gamma-synthase/cys... 565 4e-159 gi|326381816|ref|ZP_08203509.1| cystathionine gamma-synthase [Go... 551 8e-155 gi|256374851|ref|YP_003098511.1| cystathionine gamma-synthase [A... 548 5e-154 gi|262201574|ref|YP_003272782.1| cystathionine gamma-synthase [G... 548 8e-154 gi|237785421|ref|YP_002906126.1| cystathionine gamma-synthase [C... 544 1e-152 gi|134097500|ref|YP_001103161.1| cystathionine gamma-synthase [S... 530 1e-148 gi|331694805|ref|YP_004331044.1| Cys/Met metabolism pyridoxal-ph... 520 1e-145 gi|325003216|ref|ZP_08124328.1| cystathionine gamma-synthase [Ps... 516 2e-144 gi|302530128|ref|ZP_07282470.1| methionine gamma-lyase [Streptom... 511 6e-143 gi|300789918|ref|YP_003770209.1| cystathionine gamma-synthase [A... 510 1e-142 gi|302536473|ref|ZP_07288815.1| methionine gamma-lyase [Streptom... 507 1e-141 gi|328884660|emb|CCA57899.1| Cystathionine gamma-lyase [Streptom... 505 4e-141 gi|326776996|ref|ZP_08236261.1| Cys/Met metabolism pyridoxal-pho... 504 9e-141 gi|344044527|gb|EGV40203.1| cystathionine gamma-synthase [Coryne... 504 1e-140 gi|182436372|ref|YP_001824091.1| cystathionine gamma-synthase [S... 503 2e-140 gi|19553642|ref|NP_601644.1| cystathionine gamma-synthase [Coryn... 503 2e-140 gi|21223331|ref|NP_629110.1| cystathionine gamma-synthase [Strep... 503 3e-140 gi|291437596|ref|ZP_06576986.1| cystathionine gamma-synthase [St... 503 3e-140 gi|119715220|ref|YP_922185.1| cystathionine gamma-lyase [Nocardi... 502 3e-140 gi|29829847|ref|NP_824481.1| cystathionine gamma-synthase [Strep... 502 3e-140 gi|320008890|gb|ADW03740.1| Cys/Met metabolism pyridoxal-phospha... 502 4e-140 gi|271969752|ref|YP_003343948.1| cystathionine gamma-lyase [Stre... 502 5e-140 >gi|15608219|ref|NP_215595.1| cystathionine gamma-synthase [Mycobacterium tuberculosis H37Rv] gi|15840515|ref|NP_335552.1| cystathionine gamma-synthase [Mycobacterium tuberculosis CDC1551] gi|31792270|ref|NP_854763.1| cystathionine gamma-synthase [Mycobacterium bovis AF2122/97] 77 more sequence titles Length=388 Score = 783 bits (2022), Expect = 0.0, Method: Compositional matrix adjust. Identities = 388/388 (100%), Positives = 388/388 (100%), Gaps = 0/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG Sbjct 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK Sbjct 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV Sbjct 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG Sbjct 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL Sbjct 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIEDIADLLGDLEQALG Sbjct 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 >gi|254550070|ref|ZP_05140517.1| cystathionine gamma-synthase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=420 Score = 783 bits (2021), Expect = 0.0, Method: Compositional matrix adjust. Identities = 388/388 (100%), Positives = 388/388 (100%), Gaps = 0/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG Sbjct 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK Sbjct 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV Sbjct 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG Sbjct 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL Sbjct 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIEDIADLLGDLEQALG Sbjct 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 >gi|240170288|ref|ZP_04748947.1| cystathionine gamma-synthase [Mycobacterium kansasii ATCC 12478] Length=388 Score = 699 bits (1803), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/388 (89%), Positives = 362/388 (94%), Gaps = 0/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 M++DR GH G AT+AIHAGYRPD ATGAVN PIYASSTFAQDGVGGLRGG+EYARTG Sbjct 1 MNDDRRGHHQFVGLATKAIHAGYRPDSATGAVNAPIYASSTFAQDGVGGLRGGYEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEASLAAVEEG RAFSSGMAA DCALRAML PGDHVVIPDDAYGGTFRLIDK Sbjct 61 NPTRAALEASLAAVEEGGHCRAFSSGMAAADCALRAMLSPGDHVVIPDDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFTRW+V+YTPV L+DLDAV AAITPRTRLIWVETPTNPLLSIADI IA+LG D SA+V Sbjct 121 VFTRWNVEYTPVALSDLDAVRAAITPRTRLIWVETPTNPLLSIADIAQIAQLGADSSARV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGADVVLHSTTKYIGGHSDVVGGALVTNDEELD+ F FLQNGAG Sbjct 181 LVDNTFASPALQQPLTLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQAFGFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVA+FLA+HP+VS+VLYPGLP HPGH+IAA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAQFLAEHPAVSTVLYPGLPEHPGHDIAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRM+AGR AA++LCA T VFILAESLGGVESLIEHP+AMTHASTAGSQL Sbjct 301 RQMRGFGGMVSVRMKAGREAARNLCANTGVFILAESLGGVESLIEHPAAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIEDIADLLGDLEQALG Sbjct 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 >gi|15828287|ref|NP_302550.1| cystathionine gamma-synthase [Mycobacterium leprae TN] gi|221230764|ref|YP_002504180.1| cystathionine gamma-synthase [Mycobacterium leprae Br4923] gi|1170929|sp|P46807.1|METB_MYCLE RecName: Full=Cystathionine gamma-synthase; Short=CGS; AltName: Full=O-succinylhomoserine (thiol)-lyase gi|699273|gb|AAA63036.1| metB [Mycobacterium leprae] gi|13093980|emb|CAC31910.1| cystathionine [gamma]-synthase [Mycobacterium leprae] gi|219933871|emb|CAR72492.1| cystathionine [gamma]-synthase [Mycobacterium leprae Br4923] Length=388 Score = 689 bits (1779), Expect = 0.0, Method: Compositional matrix adjust. Identities = 338/387 (88%), Positives = 355/387 (92%), Gaps = 0/387 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MSED GH GI+G AT+AIHAGYRPDPATGAVNVPIYASSTFAQDGVG LRGGFEYARTG Sbjct 1 MSEDYRGHHGITGLATKAIHAGYRPDPATGAVNVPIYASSTFAQDGVGELRGGFEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NP RAALEASLA VEEG FARAFSSGMAA+DCALR MLRPGDHV+IPDD YGGTFRLIDK Sbjct 61 NPMRAALEASLATVEEGVFARAFSSGMAASDCALRVMLRPGDHVIIPDDVYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT+W+V YTPV L+DLDAV AAIT RTRLIWVETPTNPLLSIADIT+I ELG S KV Sbjct 121 VFTQWNVDYTPVPLSDLDAVRAAITSRTRLIWVETPTNPLLSIADITSIGELGKKHSVKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGADVVLHSTTKYIGGHSDVVGGALVTNDEELD+ F FLQNGAG Sbjct 181 LVDNTFASPALQQPLMLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQAFGFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVP PFDAYLTMRGLKTLVLRMQRH+ENA VAEFLA HPSVS+VLYPGLPSHPGHE+AA Sbjct 241 AVPSPFDAYLTMRGLKTLVLRMQRHNENAITVAEFLAGHPSVSAVLYPGLPSHPGHEVAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVS+RMRAGR AAQDLCA+T+VF LAESLGGVESLIE PSAMTHAST GSQL Sbjct 301 RQMRGFGGMVSLRMRAGRLAAQDLCARTKVFTLAESLGGVESLIEQPSAMTHASTTGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQAL 387 EVPDDLVRLSVGIED+ DLL DL+QAL Sbjct 361 EVPDDLVRLSVGIEDVGDLLCDLKQAL 387 >gi|296169943|ref|ZP_06851552.1| cystathionine beta-lyase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295895407|gb|EFG75112.1| cystathionine beta-lyase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=386 Score = 674 bits (1738), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/387 (87%), Positives = 355/387 (92%), Gaps = 2/387 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MS D TGH +G AT+AIHAGYRPDPATGAVN PIYASSTFAQDGVG LRGGFEYARTG Sbjct 1 MSADHTGH--FTGLATKAIHAGYRPDPATGAVNAPIYASSTFAQDGVGALRGGFEYARTG 58 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEASLAAVE G +ARAF+SGMAATDCALRAMLRPGDHV+IP DAYGGTFRLIDK Sbjct 59 NPTRAALEASLAAVEGGGYARAFASGMAATDCALRAMLRPGDHVIIPTDAYGGTFRLIDK 118 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT+W V+YTPV L+D+DAV AAITP+TRLIWVETPTNPLLSIADI A+A LG S KV Sbjct 119 VFTQWGVRYTPVALSDVDAVRAAITPQTRLIWVETPTNPLLSIADIAALAGLGQQSSVKV 178 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGADVVLHSTTKYIGGHSDVVGGALVT+D ELD FAFLQNGAG Sbjct 179 LVDNTFASPALQQPLTLGADVVLHSTTKYIGGHSDVVGGALVTDDPELDAAFAFLQNGAG 238 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENA AVAEFLA HP+VS+VLYPGLP HPGH++AA Sbjct 239 AVPGPFDAYLTMRGLKTLVLRMQRHSENAWAVAEFLAGHPAVSAVLYPGLPGHPGHDVAA 298 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRMR GR+AA+DLC +T VFILAESLGGVESLIEHPSAMTHASTAGSQL Sbjct 299 RQMRGFGGMVSVRMRGGRQAARDLCGRTEVFILAESLGGVESLIEHPSAMTHASTAGSQL 358 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQAL 387 EVPDDLVRLSVGIED+ADLL DL QAL Sbjct 359 EVPDDLVRLSVGIEDVADLLADLGQAL 385 >gi|183984359|ref|YP_001852650.1| cystathionine gamma-synthase MetB (cgs) [Mycobacterium marinum M] gi|183177685|gb|ACC42795.1| cystathionine gamma-synthase MetB (cgs) [Mycobacterium marinum M] Length=388 Score = 669 bits (1725), Expect = 0.0, Method: Compositional matrix adjust. Identities = 338/388 (88%), Positives = 357/388 (93%), Gaps = 0/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 M +D +G ATRAIH+GYRPDPATGAVN PIYASSTFAQDGVGGLRGG+EYARTG Sbjct 1 MKDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGLRGGYEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR ALEA+LAAVE+ AF RAFSSGMAA DCALRAMLRPGDHVVIPDDAYGGTFRLIDK Sbjct 61 NPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT W+V+YTPV LADLDAV AAI P TRLIWVETPTNPLLSIADI IA+LG D SAKV Sbjct 121 VFTGWNVEYTPVALADLDAVRAAIRPTTRLIWVETPTNPLLSIADIAGIAQLGADSSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGADVVLHSTTKYIGGHSDVVGGALVTNDEELD+ FAFLQNGAG Sbjct 181 LVDNTFASPALQQPLSLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENA AVAEFLA+HP++S+VLYPGLPSHPGH +AA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAVAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRMRAGR AA+ LCAKT +FILAESLGGVESLIEHPSAMTHASTAGSQL Sbjct 301 RQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGGVESLIEHPSAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIED+ADLL DL+QALG Sbjct 361 EVPDDLVRLSVGIEDVADLLDDLKQALG 388 >gi|118616091|ref|YP_904423.1| cystathionine gamma-synthase [Mycobacterium ulcerans Agy99] gi|118568201|gb|ABL02952.1| cystathionine gamma-synthase MetB (cgs) [Mycobacterium ulcerans Agy99] Length=388 Score = 667 bits (1721), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/388 (87%), Positives = 356/388 (92%), Gaps = 0/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 M +D +G ATRAIH+GYRPDPATGAVN PIYASSTFAQDGVGGLRGG+EYARTG Sbjct 1 MKDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGLRGGYEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR ALEA+LAAVE+ AF RAFSSGMAA DCALRAMLRPGDHVVIPDDAYGGTFRLIDK Sbjct 61 NPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT W+V+YTPV LADLDAV AAI P TRLIWVETPTNPLLSIADI IA+LG D SAKV Sbjct 121 VFTGWNVEYTPVALADLDAVRAAIRPTTRLIWVETPTNPLLSIADIAGIAQLGADSSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGADVVLHSTTKYIGGHSDVVGGALVTNDEELD+ FAFLQNGAG Sbjct 181 LVDNTFASPALQQPLSLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENA AVAEFLA+HP++S+VLYPGLPSHPGH +AA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAVAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRMRAGR AA+ LCAKT +FILAESLG VESLIEHPSAMTHASTAGSQL Sbjct 301 RQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGSVESLIEHPSAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIED+ADLL DL+QALG Sbjct 361 EVPDDLVRLSVGIEDVADLLDDLKQALG 388 >gi|325054102|pdb|3QHX|A Chain A, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 Bound To Hepes gi|325054103|pdb|3QHX|B Chain B, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 Bound To Hepes gi|325054104|pdb|3QHX|C Chain C, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 Bound To Hepes gi|325054105|pdb|3QHX|D Chain D, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 Bound To Hepes gi|325054106|pdb|3QI6|A Chain A, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 gi|325054107|pdb|3QI6|B Chain B, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 gi|325054108|pdb|3QI6|C Chain C, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 gi|325054109|pdb|3QI6|D Chain D, Crystal Structure Of Cystathionine Gamma-Synthase Metb (Cgs) From Mycobacterium Ulcerans Agy99 Length=392 Score = 664 bits (1712), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/388 (87%), Positives = 355/388 (92%), Gaps = 0/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 M +D +G ATRAIH+GYRPDPATGAVN PIYASSTFAQDGVGGLRGG+EYARTG Sbjct 5 MKDDHKAQHRFAGLATRAIHSGYRPDPATGAVNAPIYASSTFAQDGVGGLRGGYEYARTG 64 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR ALEA+LAAVE+ AF RAFSSGMAA DCALRAMLRPGDHVVIPDDAYGGTFRLIDK Sbjct 65 NPTRTALEAALAAVEDAAFGRAFSSGMAAADCALRAMLRPGDHVVIPDDAYGGTFRLIDK 124 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT W+V+YTPV LADLDAV AAI P TRLIWVETPTNPLLSIADI IA+LG D SAKV Sbjct 125 VFTGWNVEYTPVALADLDAVRAAIRPTTRLIWVETPTNPLLSIADIAGIAQLGADSSAKV 184 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGADVVLHSTT YIGGHSDVVGGALVTNDEELD+ FAFLQNGAG Sbjct 185 LVDNTFASPALQQPLSLGADVVLHSTTXYIGGHSDVVGGALVTNDEELDQSFAFLQNGAG 244 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENA AVAEFLA+HP++S+VLYPGLPSHPGH +AA Sbjct 245 AVPGPFDAYLTMRGLKTLVLRMQRHSENAAAVAEFLAEHPAISTVLYPGLPSHPGHAVAA 304 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRMRAGR AA+ LCAKT +FILAESLG VESLIEHPSAMTHASTAGSQL Sbjct 305 RQMRGFGGMVSVRMRAGRTAAEQLCAKTNIFILAESLGSVESLIEHPSAMTHASTAGSQL 364 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIED+ADLL DL+QALG Sbjct 365 EVPDDLVRLSVGIEDVADLLDDLKQALG 392 >gi|41407124|ref|NP_959960.1| cystathionine gamma-synthase [Mycobacterium avium subsp. paratuberculosis K-10] gi|118463216|ref|YP_880449.1| cystathionine gamma-synthase [Mycobacterium avium 104] gi|254774086|ref|ZP_05215602.1| cystathionine gamma-synthase [Mycobacterium avium subsp. avium ATCC 25291] gi|41395475|gb|AAS03343.1| MetB [Mycobacterium avium subsp. paratuberculosis K-10] gi|118164503|gb|ABK65400.1| cystathionine beta-lyase MetC [Mycobacterium avium 104] gi|336461453|gb|EGO40323.1| cystathionine beta-lyase/cystathionine gamma-synthase [Mycobacterium avium subsp. paratuberculosis S397] Length=388 Score = 659 bits (1701), Expect = 0.0, Method: Compositional matrix adjust. Identities = 322/376 (86%), Positives = 345/376 (92%), Gaps = 0/376 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MS+D H SG AT+AIHAGYRPDPATGAVN PIYASSTFAQDGVG LRGG+EYARTG Sbjct 1 MSDDGNAHPEFSGLATKAIHAGYRPDPATGAVNTPIYASSTFAQDGVGALRGGYEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEA+LAAVE G+ RAF+SGMAATDCALRA+LRPGDHVVIP+DAYGGTFRLIDK Sbjct 61 NPTRAALEATLAAVEAGSHGRAFASGMAATDCALRAVLRPGDHVVIPNDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFTRW+V+YTPV L LDAV AAITPRTRLIWVETPTNPLLSIADI A+A+LG SAKV Sbjct 121 VFTRWNVEYTPVPLHQLDAVAAAITPRTRLIWVETPTNPLLSIADIAALAQLGHQHSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGAD+VLHSTTKYIGGHSDVVGGALVTND ELD+ F FLQNGAG Sbjct 181 LVDNTFASPALQQPLTLGADIVLHSTTKYIGGHSDVVGGALVTNDAELDDAFGFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRH+ENA AVA+FLA HP+VS+VLYPGLP HPGH++AA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHTENASAVAQFLAGHPAVSAVLYPGLPGHPGHDVAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQM GFGGMVSVRMR GR+AA+ LCA TRVFILAESLGGVESLIEHPSAMTHASTAGSQL Sbjct 301 RQMSGFGGMVSVRMRGGRQAARKLCANTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDI 376 EVPDDLVRLSVGIED+ Sbjct 361 EVPDDLVRLSVGIEDV 376 >gi|254820657|ref|ZP_05225658.1| cystathionine gamma-synthase [Mycobacterium intracellulare ATCC 13950] Length=388 Score = 657 bits (1695), Expect = 0.0, Method: Compositional matrix adjust. Identities = 333/387 (87%), Positives = 357/387 (93%), Gaps = 0/387 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MS+D H +G AT+AIHAGYRPDPATGAVN PIYASSTFAQDGVG LRGGFEYARTG Sbjct 1 MSDDGNPHPEFTGLATKAIHAGYRPDPATGAVNAPIYASSTFAQDGVGALRGGFEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEA+LAAVEEG++ RAF+SGMAATDCALR +LRPGDHVVIP+DAYGGTFRLIDK Sbjct 61 NPTRAALEAALAAVEEGSYGRAFASGMAATDCALRTVLRPGDHVVIPNDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT+W+V YTPV L +LDAV AAITPRTR+IWVETPTNPLLSIADI AIAELG SAKV Sbjct 121 VFTQWNVDYTPVALHELDAVAAAITPRTRMIWVETPTNPLLSIADIAAIAELGEQHSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGAD+VLHSTTKYIGGHSDVVGGALVTND+ELD+ F FLQNGAG Sbjct 181 LVDNTFASPALQQPLTLGADIVLHSTTKYIGGHSDVVGGALVTNDQELDDAFGFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AVPGPFDAYLTMRGLKTLVLRMQRHSENA AVAEFLA H +VS+VLYPGLPSHPGHE+AA Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENAMAVAEFLAGHRAVSAVLYPGLPSHPGHEVAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMRGFGGMVSVRM+ GR AA DLCA T+VFILAESLGGVESLIEHPSAMTHASTAGSQL Sbjct 301 RQMRGFGGMVSVRMKGGRDAAGDLCANTKVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQAL 387 EVPDDLVRLSVGIED+ADL+ DL+QAL Sbjct 361 EVPDDLVRLSVGIEDVADLVADLQQAL 387 >gi|342861670|ref|ZP_08718316.1| cystathionine gamma-synthase [Mycobacterium colombiense CECT 3035] gi|342130804|gb|EGT84100.1| cystathionine gamma-synthase [Mycobacterium colombiense CECT 3035] Length=395 Score = 652 bits (1683), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/394 (85%), Positives = 355/394 (91%), Gaps = 7/394 (1%) Query 1 MSEDRTG---HQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYA 57 MS+D G H +G ATRAIHAGYRPDPATGAVN PIYASSTFAQDGVG LRGGFEYA Sbjct 1 MSDDHPGTGGHPEFTGLATRAIHAGYRPDPATGAVNAPIYASSTFAQDGVGALRGGFEYA 60 Query 58 RTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRL 117 RTGNPTRAALEA+LAAVE+GA+ RAF SGMAATDCALRA+LRPGDHVVIP+DAYGGTFRL Sbjct 61 RTGNPTRAALEAALAAVEDGAYGRAFGSGMAATDCALRALLRPGDHVVIPNDAYGGTFRL 120 Query 118 IDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRS 177 IDKVFT+W+V+YTPV L DLDAV AA TPRTRLIW ETPTNPLLSIADI A+AEL R Sbjct 121 IDKVFTQWNVEYTPVALHDLDAVAAATTPRTRLIWAETPTNPLLSIADIAALAELAAGRD 180 Query 178 AK----VLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFA 233 AK +LVDNTFASPALQ+PL LGAD+VLHSTTKYIGGHSDVVGGALVTND+ELDE FA Sbjct 181 AKNPAKLLVDNTFASPALQRPLTLGADIVLHSTTKYIGGHSDVVGGALVTNDQELDEAFA 240 Query 234 FLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSH 293 FLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENA AVAEFL HP+VS+VLYPGLPSH Sbjct 241 FLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENASAVAEFLEGHPAVSAVLYPGLPSH 300 Query 294 PGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHA 353 PGHE+AARQM FGGMVSVRMR GR AA+DLC +T+VFILAESLGGVESLIEHPSAMTHA Sbjct 301 PGHEVAARQMSAFGGMVSVRMRGGRDAARDLCGRTKVFILAESLGGVESLIEHPSAMTHA 360 Query 354 STAGSQLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 STAGSQLEVPDDLVRLSVGIEDIADLL DL QAL Sbjct 361 STAGSQLEVPDDLVRLSVGIEDIADLLADLGQAL 394 >gi|120405622|ref|YP_955451.1| cystathionine gamma-synthase [Mycobacterium vanbaalenii PYR-1] gi|119958440|gb|ABM15445.1| cystathionine gamma-lyase [Mycobacterium vanbaalenii PYR-1] Length=393 Score = 636 bits (1641), Expect = 2e-180, Method: Compositional matrix adjust. Identities = 313/390 (81%), Positives = 345/390 (89%), Gaps = 2/390 (0%) Query 1 MSEDRTG--HQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ H GPATRAIHAGYRPDPATG VN PIYASSTFAQDGVGGLRGGFEY+R Sbjct 1 MSEQRSASDHYRAFGPATRAIHAGYRPDPATGVVNPPIYASSTFAQDGVGGLRGGFEYSR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR+ LE +LAA+E + RAFSSGMAATDC LRA+LRPGDH+VIPDDAYGGTFRLI Sbjct 61 TGNPTRSVLEGALAAMEGASHGRAFSSGMAATDCVLRAVLRPGDHLVIPDDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVF+ W + YT V L DLD V AA+T RT+LIW+ETPTNPLLSIADI AIAE+G A Sbjct 121 DKVFSLWGISYTAVALGDLDRVRAAVTDRTKLIWIETPTNPLLSIADIAAIAEVGAATGA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 KVLVDNTFASPALQQPL LGAD+VLHSTTKYIGGHSDVVGGAL+TNDE LD+ FAFLQNG Sbjct 181 KVLVDNTFASPALQQPLALGADIVLHSTTKYIGGHSDVVGGALLTNDEALDDAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 AGAVPGPFDAYLT+RGLKTL LRMQRHSENA A+AEFL HP+V++VLYPGLPSHP H++ Sbjct 241 AGAVPGPFDAYLTIRGLKTLPLRMQRHSENAAAIAEFLDGHPAVTTVLYPGLPSHPNHDV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 AARQM GFGGMVSVR+R G +AA+D CA+T +FILAESLGGVESLIE+P AMTHASTAGS Sbjct 301 AARQMSGFGGMVSVRLRGGPQAARDFCARTEIFILAESLGGVESLIEYPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQALG 388 QLEVPDDLVRLSVGIED+ADLLGD+EQALG Sbjct 361 QLEVPDDLVRLSVGIEDVADLLGDVEQALG 390 >gi|333989665|ref|YP_004522279.1| cystathionine gamma-synthase MetB (cgs) [Mycobacterium sp. JDM601] gi|333485633|gb|AEF35025.1| cystathionine gamma-synthase MetB (cgs) [Mycobacterium sp. JDM601] Length=381 Score = 635 bits (1638), Expect = 4e-180, Method: Compositional matrix adjust. Identities = 315/379 (84%), Positives = 340/379 (90%), Gaps = 0/379 (0%) Query 9 QGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALE 68 G GP+T AIHAG+RPDPATGAVN PIYASSTFAQDGVGGLRGG+EYART NPTR ALE Sbjct 2 HGPIGPSTTAIHAGFRPDPATGAVNPPIYASSTFAQDGVGGLRGGYEYARTSNPTRTALE 61 Query 69 ASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQ 128 +LAAVE+G + RAFSSGMAATDCALRAMLRPGDH++IPDDAYGGTFRLIDKVFT W + Sbjct 62 TALAAVEQGRYGRAFSSGMAATDCALRAMLRPGDHLIIPDDAYGGTFRLIDKVFTGWGLA 121 Query 129 YTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFAS 188 YTPV L+DLDAV AA+T +TRLI VETPTNPLLSI+DI +IA +G + AKVLVDNTFAS Sbjct 122 YTPVALSDLDAVRAALTDKTRLILVETPTNPLLSISDIESIAAIGRESGAKVLVDNTFAS 181 Query 189 PALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDA 248 PALQQPL LGADVVLHSTTKYIGGHSDVVGGALVT+DEELD FAFLQNGAGAVPGPFDA Sbjct 182 PALQQPLTLGADVVLHSTTKYIGGHSDVVGGALVTDDEELDAAFAFLQNGAGAVPGPFDA 241 Query 249 YLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGG 308 YLT+RGLKTLVLRMQRHSENA AVAEFLA H +V +VLYPGLP HPGH+IAARQMRGFGG Sbjct 242 YLTLRGLKTLVLRMQRHSENAAAVAEFLAGHAAVDTVLYPGLPGHPGHDIAARQMRGFGG 301 Query 309 MVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVR 368 MVSVR+ GR AA+ LCA T +FILAESLGGVESLIEHP AMTHASTAGSQLEVPDDLVR Sbjct 302 MVSVRLHGGRGAAEKLCAATEIFILAESLGGVESLIEHPGAMTHASTAGSQLEVPDDLVR 361 Query 369 LSVGIEDIADLLGDLEQAL 387 LSVGIEDI DLL DL+QAL Sbjct 362 LSVGIEDIDDLLEDLKQAL 380 >gi|145222634|ref|YP_001133312.1| cystathionine gamma-synthase [Mycobacterium gilvum PYR-GCK] gi|315443099|ref|YP_004075978.1| cystathionine gamma-lyase [Mycobacterium sp. Spyr1] gi|145215120|gb|ABP44524.1| cystathionine gamma-lyase [Mycobacterium gilvum PYR-GCK] gi|315261402|gb|ADT98143.1| cystathionine gamma-lyase [Mycobacterium sp. Spyr1] Length=390 Score = 634 bits (1635), Expect = 8e-180, Method: Compositional matrix adjust. Identities = 306/376 (82%), Positives = 340/376 (91%), Gaps = 0/376 (0%) Query 13 GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLA 72 GPAT+AIHAGYRPDPATG VN PIYASSTFAQDGVGGLRGGFEYARTGNPTR+ LE++LA Sbjct 15 GPATKAIHAGYRPDPATGVVNPPIYASSTFAQDGVGGLRGGFEYARTGNPTRSVLESALA 74 Query 73 AVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPV 132 A+E ++ RAFSSGMAATDC LRA+LRPGDH+VIPDDAYGGTFRLIDKVF+ W + YT V Sbjct 75 AMEGASYGRAFSSGMAATDCVLRAVLRPGDHIVIPDDAYGGTFRLIDKVFSLWGISYTAV 134 Query 133 RLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQ 192 L+DLD V AAIT RTRL+W+ETPTNPLLSIADI AI+ LG ++ KVLVDNTFASPALQ Sbjct 135 ALSDLDRVRAAITDRTRLVWIETPTNPLLSIADIAAISALGAEKDVKVLVDNTFASPALQ 194 Query 193 QPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTM 252 QPL LGAD+VLHSTTKYIGGHSDVVGGA++TNDE LD FAFLQNGAGAVPGPFDAYLT+ Sbjct 195 QPLALGADIVLHSTTKYIGGHSDVVGGAVLTNDEALDGAFAFLQNGAGAVPGPFDAYLTI 254 Query 253 RGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSV 312 RGLKTL LRMQRHSENA AVAEFL HP+V +VLYPGLPSHPGHE+AARQM GFGGM+SV Sbjct 255 RGLKTLPLRMQRHSENATAVAEFLDGHPAVDTVLYPGLPSHPGHEVAARQMSGFGGMISV 314 Query 313 RMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVG 372 R+ G +AA+D CA+T +FILAESLGGVESLIE+P AMTHASTAGSQLEVPDDLVRLSVG Sbjct 315 RLAGGPQAARDFCARTEIFILAESLGGVESLIEYPGAMTHASTAGSQLEVPDDLVRLSVG 374 Query 373 IEDIADLLGDLEQALG 388 IED+ADL+GD+EQALG Sbjct 375 IEDVADLVGDVEQALG 390 >gi|108801110|ref|YP_641307.1| cystathionine gamma-synthase [Mycobacterium sp. MCS] gi|119870251|ref|YP_940203.1| cystathionine gamma-synthase [Mycobacterium sp. KMS] gi|126436948|ref|YP_001072639.1| cystathionine gamma-synthase [Mycobacterium sp. JLS] gi|108771529|gb|ABG10251.1| cystathionine gamma-lyase [Mycobacterium sp. MCS] gi|119696340|gb|ABL93413.1| cystathionine gamma-lyase [Mycobacterium sp. KMS] gi|126236748|gb|ABO00149.1| cystathionine gamma-lyase [Mycobacterium sp. JLS] Length=392 Score = 632 bits (1630), Expect = 3e-179, Method: Compositional matrix adjust. Identities = 307/391 (79%), Positives = 347/391 (89%), Gaps = 4/391 (1%) Query 1 MSEDRTGH---QGI-SGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEY 56 M+E R+ H G+ +G AT+AIHAGY PDP TGAVN PIYASSTFAQDGVGGLRGGFEY Sbjct 1 MTEQRSAHGPAHGLATGLATKAIHAGYAPDPRTGAVNTPIYASSTFAQDGVGGLRGGFEY 60 Query 57 ARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFR 116 ARTGNPTR +LE++LAAVEE + RAF+SGMAATDCALRA+LRPGDH+VIPDDAYGGTFR Sbjct 61 ARTGNPTRQSLESALAAVEEAGYGRAFASGMAATDCALRAVLRPGDHLVIPDDAYGGTFR 120 Query 117 LIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDR 176 LIDKVF++W + YT V L+DLDAV AAITP+T++IWVETPTNPLLSIADI IA + + Sbjct 121 LIDKVFSQWGISYTAVALSDLDAVRAAITPQTKMIWVETPTNPLLSIADIAGIAGIAAES 180 Query 177 SAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQ 236 KVLVDNTFASPALQQPL LGAD+VLHSTTKYIGGHSDVVGGAL+TNDEELD FAFLQ Sbjct 181 GLKVLVDNTFASPALQQPLLLGADIVLHSTTKYIGGHSDVVGGALLTNDEELDTAFAFLQ 240 Query 237 NGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGH 296 NG+GAVPGPFDAYLT+RGLKTLV+RMQRHSENA AVAEFL HP++ +VLYPGLPSHPGH Sbjct 241 NGSGAVPGPFDAYLTLRGLKTLVVRMQRHSENAAAVAEFLDGHPAIDTVLYPGLPSHPGH 300 Query 297 EIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTA 356 ++AA+QM GFGGMVSVR+ G +AA++ CA+T +FILAESLGGVESLIEHP AMTHASTA Sbjct 301 DVAAKQMSGFGGMVSVRLHGGPKAAREFCARTGIFILAESLGGVESLIEHPGAMTHASTA 360 Query 357 GSQLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 GSQLEVP+DLVRLSVGIED ADL+ DLEQAL Sbjct 361 GSQLEVPEDLVRLSVGIEDRADLIADLEQAL 391 >gi|118467584|ref|YP_889511.1| cystathionine gamma-synthase [Mycobacterium smegmatis str. MC2 155] gi|118168871|gb|ABK69767.1| putative cystathionine gamma-synthase [Mycobacterium smegmatis str. MC2 155] Length=384 Score = 617 bits (1591), Expect = 1e-174, Method: Compositional matrix adjust. Identities = 311/388 (81%), Positives = 343/388 (89%), Gaps = 4/388 (1%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MSE R H G AT+AIHAGY+PDPATGAVN PIYASSTFAQDGVGGLRGGFEYARTG Sbjct 1 MSEHRKWH----GLATKAIHAGYQPDPATGAVNTPIYASSTFAQDGVGGLRGGFEYARTG 56 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR +LEA+LAAVEE F RAFSSGMAATDCALRA+LRPGDHVVIPDDAYGGTFRLIDK Sbjct 57 NPTRQSLEAALAAVEEARFGRAFSSGMAATDCALRAVLRPGDHVVIPDDAYGGTFRLIDK 116 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFT W + +TP L+DLD+V +AITP+TRLIWVETPTNPLL++ADI I ++ + KV Sbjct 117 VFTHWGISHTPAALSDLDSVRSAITPKTRLIWVETPTNPLLNVADIAGIVQIASSTGVKV 176 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPL LGAD+VLHSTTKYIGGHSDVVGGAL+TNDEELD FAFLQNGAG Sbjct 177 LVDNTFASPALQQPLLLGADIVLHSTTKYIGGHSDVVGGALLTNDEELDAAFAFLQNGAG 236 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 VPGPFDAYLTMRGLKTLVLRM++HSENA +AEFL HP+V +VLYPGLPSHP H++AA Sbjct 237 GVPGPFDAYLTMRGLKTLVLRMRQHSENAALIAEFLDGHPAVQTVLYPGLPSHPNHDVAA 296 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQM GFGGMVSVR+R G +AA+DLC++T +FILAESLGGVESLIE+P AMTHASTAGSQL Sbjct 297 RQMTGFGGMVSVRLRGGPQAARDLCSRTEIFILAESLGGVESLIEYPGAMTHASTAGSQL 356 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVPDDLVRLSVGIE ADLL DLEQALG Sbjct 357 EVPDDLVRLSVGIEHSADLLADLEQALG 384 >gi|169628290|ref|YP_001701939.1| cystathionine gamma-synthase [Mycobacterium abscessus ATCC 19977] gi|169240257|emb|CAM61285.1| Probable cystathionine gamma-synthase (CGS) [Mycobacterium abscessus] Length=390 Score = 616 bits (1589), Expect = 2e-174, Method: Compositional matrix adjust. Identities = 299/389 (77%), Positives = 339/389 (88%), Gaps = 2/389 (0%) Query 1 MSEDRTGHQG--ISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ G +TRAIH G+ DP TGAVNVPIYASSTFAQDGVG LRGGFEYAR Sbjct 1 MSEQRSAADASRWQGFSTRAIHGGFHADPQTGAVNVPIYASSTFAQDGVGQLRGGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTRA LEASLAA+E+ F RAFSSGMAATDC LRA+LRPGDH++IP+DAYGGTFRLI Sbjct 61 TGNPTRAVLEASLAALEDAHFGRAFSSGMAATDCVLRALLRPGDHLIIPNDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVF++W +++TPV +AD+DA+ AAITP T+LIW+ETPTNPLLSIADI A+A++ + S Sbjct 121 DKVFSQWGIRHTPVPVADVDAIRAAITPTTKLIWLETPTNPLLSIADIAAVAQVAAEHSV 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K+LVDNTFASPALQQPL LGAD+ LHSTTKYIGGHSDVVGGAL+TNDEELD FAFLQNG Sbjct 181 KLLVDNTFASPALQQPLNLGADIALHSTTKYIGGHSDVVGGALLTNDEELDTAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 AGAVPGPFD YLT RG+KTL LRMQRHSENA AVAE+LA H +V+ +YPGL SHPGH + Sbjct 241 AGAVPGPFDGYLTYRGIKTLALRMQRHSENAQAVAEYLAGHSAVAQTIYPGLESHPGHAV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 AARQMRGFGGMVSVR+ GR+AA DLC++T +FILAESLGGVESLIEHP AMTHASTAGS Sbjct 301 AARQMRGFGGMVSVRLAGGRQAALDLCSRTELFILAESLGGVESLIEHPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 LEVPDDLVRLSVGIE++ DL+GDLEQAL Sbjct 361 LLEVPDDLVRLSVGIEEVGDLIGDLEQAL 389 >gi|312138726|ref|YP_004006062.1| cystathionine beta and gamma-lyase/cystathionine gamma-synthase metb [Rhodococcus equi 103S] gi|311888065|emb|CBH47377.1| cystathionine beta and gamma-lyase/cystathionine gamma-synthase MetB [Rhodococcus equi 103S] Length=384 Score = 607 bits (1565), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 288/382 (76%), Positives = 334/382 (88%), Gaps = 1/382 (0%) Query 8 HQGIS-GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAA 66 QGIS G +TRAIHAGY PDP TGAVNVPIYASSTFAQDGVGG+RGGFEYARTGNPTR Sbjct 3 EQGISSGFSTRAIHAGYEPDPQTGAVNVPIYASSTFAQDGVGGMRGGFEYARTGNPTRRP 62 Query 67 LEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWD 126 LEA+LAA+E G F RAF SGMAATDC LR++LRPGDH+VIP+DAYGGTFRLIDKVFT+W Sbjct 63 LEANLAALESGTFGRAFGSGMAATDCVLRSLLRPGDHLVIPNDAYGGTFRLIDKVFTQWG 122 Query 127 VQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTF 186 ++YTP ++D+DAV AAI P T+L+WVETPTNPLL++ DI AI+E+ AK++VDNTF Sbjct 123 IEYTPAAVSDVDAVRAAIRPNTKLVWVETPTNPLLNVGDIAAISEVAQAAGAKLVVDNTF 182 Query 187 ASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPF 246 ASP LQQPL+LGAD+ LHSTTKYIGGHSDVVGGALVTNDEELD +FAFLQNGAGAVPGPF Sbjct 183 ASPYLQQPLQLGADIALHSTTKYIGGHSDVVGGALVTNDEELDTKFAFLQNGAGAVPGPF 242 Query 247 DAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGF 306 DA+LTMRG+KTL LRM+RHS+NA + + L H +++ V+YPGL SHPGH +AA+QMR F Sbjct 243 DAFLTMRGIKTLALRMERHSDNAEKIVDLLTGHSAIAQVIYPGLESHPGHAVAAKQMRRF 302 Query 307 GGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDL 366 GGM+SVR++ GR+AA D CA+T++F LAESLGGVESLIEHP AMTHASTAGS LEVP+DL Sbjct 303 GGMISVRLKGGRQAALDFCARTQIFTLAESLGGVESLIEHPGAMTHASTAGSALEVPEDL 362 Query 367 VRLSVGIEDIADLLGDLEQALG 388 VRLSVGIED ADLL D+EQALG Sbjct 363 VRLSVGIEDAADLLADVEQALG 384 >gi|325676582|ref|ZP_08156260.1| cystathionine beta-lyase [Rhodococcus equi ATCC 33707] gi|325552760|gb|EGD22444.1| cystathionine beta-lyase [Rhodococcus equi ATCC 33707] Length=384 Score = 605 bits (1561), Expect = 3e-171, Method: Compositional matrix adjust. Identities = 287/382 (76%), Positives = 333/382 (88%), Gaps = 1/382 (0%) Query 8 HQGIS-GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAA 66 QGIS G +TRAIHAGY PDP TGAVNVPIYASSTFAQDGVGG+RGGFEYARTGNPTR Sbjct 3 EQGISSGFSTRAIHAGYEPDPQTGAVNVPIYASSTFAQDGVGGMRGGFEYARTGNPTRRP 62 Query 67 LEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWD 126 LEA+LA +E G F RAF SGMAATDC LR++LRPGDH+VIP+DAYGGTFRLIDKVFT+W Sbjct 63 LEANLAELESGTFGRAFGSGMAATDCVLRSLLRPGDHLVIPNDAYGGTFRLIDKVFTQWG 122 Query 127 VQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTF 186 ++YTP ++D+DAV AAI P T+L+WVETPTNPLL++ DI AI+E+ AK++VDNTF Sbjct 123 IEYTPAAVSDVDAVRAAIRPNTKLVWVETPTNPLLNVGDIAAISEVAQAAGAKLVVDNTF 182 Query 187 ASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPF 246 ASP LQQPL+LGAD+ LHSTTKYIGGHSDVVGGALVTNDEELD +FAFLQNGAGAVPGPF Sbjct 183 ASPYLQQPLQLGADIALHSTTKYIGGHSDVVGGALVTNDEELDTKFAFLQNGAGAVPGPF 242 Query 247 DAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGF 306 DA+LTMRG+KTL LRM+RHS+NA + + L H +++ V+YPGL SHPGH +AA+QMR F Sbjct 243 DAFLTMRGIKTLALRMERHSDNAEKIVDLLTGHSAIAQVIYPGLESHPGHAVAAKQMRRF 302 Query 307 GGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDL 366 GGM+SVR++ GR+AA D CA+T++F LAESLGGVESLIEHP AMTHASTAGS LEVP+DL Sbjct 303 GGMISVRLKGGRQAALDFCARTQIFTLAESLGGVESLIEHPGAMTHASTAGSALEVPEDL 362 Query 367 VRLSVGIEDIADLLGDLEQALG 388 VRLSVGIED ADLL D+EQALG Sbjct 363 VRLSVGIEDAADLLADVEQALG 384 >gi|226365315|ref|YP_002783098.1| cystathionine gamma-synthase [Rhodococcus opacus B4] gi|226243805|dbj|BAH54153.1| cystathionine gamma-synthase/cystathionine gamma-lyase [Rhodococcus opacus B4] Length=390 Score = 600 bits (1547), Expect = 1e-169, Method: Compositional matrix adjust. Identities = 286/389 (74%), Positives = 334/389 (86%), Gaps = 2/389 (0%) Query 1 MSEDRTGHQGIS--GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ IS G +T+A+HAG+ PDP TGAVNVPIYASSTFAQDGVGG+R GFEYAR Sbjct 1 MSEQRSKADNISWQGFSTKAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGMRNGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR LEA+LAA+E G + RAF SGMAATDC LRA LRPGDH+VIP+DAYGGTFRLI Sbjct 61 TGNPTRRPLEANLAALESGTYGRAFGSGMAATDCLLRAALRPGDHLVIPNDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVFT+W ++YTP ++D+DAV AAI P T+L+WVETPTNPLL+I DI A++++ + A Sbjct 121 DKVFTQWGIEYTPAAVSDVDAVRAAIRPNTKLVWVETPTNPLLNIGDIEALSDIAHEAGA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K++VDNTFASP LQQPL+LGAD+ LHSTTKYIGGHSDVVGGAL+TNDEELD FAFLQNG Sbjct 181 KIVVDNTFASPYLQQPLQLGADIALHSTTKYIGGHSDVVGGALITNDEELDTAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 AGAVPGPFDA+LT+RG+KTL LRM+RHS+NA V E L HP+VS V+YPGL SHPGH+I Sbjct 241 AGAVPGPFDAFLTLRGIKTLSLRMERHSDNAEKVVELLTGHPAVSQVIYPGLESHPGHKI 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 A +QMR FGGM+SVR+ G++AA D C++T +F LAESLGGVESLIEHP AMTHASTAGS Sbjct 301 AEKQMRRFGGMISVRLTGGKQAALDFCSRTEIFTLAESLGGVESLIEHPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 LEVPDDLVRLSVGIED ADL+GD+EQAL Sbjct 361 LLEVPDDLVRLSVGIEDAADLVGDIEQAL 389 >gi|111022808|ref|YP_705780.1| cystathionine gamma-synthase [Rhodococcus jostii RHA1] gi|110822338|gb|ABG97622.1| cystathionine gamma-synthase [Rhodococcus jostii RHA1] Length=390 Score = 600 bits (1547), Expect = 1e-169, Method: Compositional matrix adjust. Identities = 287/389 (74%), Positives = 334/389 (86%), Gaps = 2/389 (0%) Query 1 MSEDRTGHQGIS--GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ IS G +T+A+HAG+ PDP TGAVNVPIYASSTFAQDGVGG+R GFEYAR Sbjct 1 MSEQRSKADNISWQGFSTKAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGMRNGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR LEA+LAA+E G + RAF SGMAATDC LRA LRPGDH+VIP+DAYGGTFRLI Sbjct 61 TGNPTRRPLEANLAALESGTYGRAFGSGMAATDCLLRAALRPGDHLVIPNDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVFT+W ++YTP ++D+DAV AAI P T+L+WVETPTNPLL+I DI A++++ + A Sbjct 121 DKVFTQWGIEYTPAAVSDVDAVRAAIRPNTKLVWVETPTNPLLNIGDIEALSDVAHEAGA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K++VDNTFASP LQQPL+LGADV LHSTTKYIGGHSDVVGGALVTNDEELD FAFLQNG Sbjct 181 KIVVDNTFASPYLQQPLQLGADVALHSTTKYIGGHSDVVGGALVTNDEELDTAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 AGAVPGPFDA+LT+RG+KTL LRM+RHS+NA V E L HP+VS V+YPGL SHPGH++ Sbjct 241 AGAVPGPFDAFLTLRGIKTLSLRMERHSDNAEKVVELLTGHPAVSQVIYPGLESHPGHKV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 A +QMR FGGM+SVR+ G++AA D C++T +F LAESLGGVESLIEHP AMTHASTAGS Sbjct 301 AEKQMRRFGGMISVRLAGGKQAALDFCSRTEIFTLAESLGGVESLIEHPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 LEVPDDLVRLSVGIED ADL+GD+EQAL Sbjct 361 LLEVPDDLVRLSVGIEDAADLVGDIEQAL 389 >gi|226307752|ref|YP_002767712.1| cystathionine gamma-synthase/cystathionine gamma-lyase [Rhodococcus erythropolis PR4] gi|21280313|dbj|BAB96807.1| probable cystathionine gamma-synthase [Rhodococcus erythropolis] gi|226186869|dbj|BAH34973.1| probable cystathionine gamma-synthase/cystathionine gamma-lyase [Rhodococcus erythropolis PR4] Length=390 Score = 595 bits (1533), Expect = 6e-168, Method: Compositional matrix adjust. Identities = 283/389 (73%), Positives = 334/389 (86%), Gaps = 2/389 (0%) Query 1 MSEDRTGHQGIS--GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ IS G +T+A+HAGY PDP TGAVNVPIYASSTFAQDGVGG+R GFEYAR Sbjct 1 MSEQRSKADNISWQGFSTKAVHAGYEPDPLTGAVNVPIYASSTFAQDGVGGMRSGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR LEA+LAA+E G + RAFSSGMAATDC LR++LRPGDH+VIPDDAYGGTFRLI Sbjct 61 TGNPTRRPLEANLAALESGTYGRAFSSGMAATDCLLRSVLRPGDHLVIPDDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVFT+W ++YTP ++D+DAV AA+ T+L+WVETPTNPLL+I DI +AE+ + +A Sbjct 121 DKVFTQWGIEYTPAPVSDVDAVRAAMKSNTKLVWVETPTNPLLNIGDIELLAEVAHEGNA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K++VDNTFASP LQQPL+LGAD+ LHSTTKYIGGHSDVVGGALV NDEELD FAFLQNG Sbjct 181 KIVVDNTFASPYLQQPLQLGADIALHSTTKYIGGHSDVVGGALVCNDEELDTAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 +G VPGPFDA+LT+RG+KTL LRM+RHS+NA V E L HP+V+SV+YPGL SHP H++ Sbjct 241 SGGVPGPFDAFLTLRGIKTLALRMERHSDNAEKVVELLDGHPAVASVIYPGLASHPSHKV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 AA+QMR FGGM+SVR++ G+ AA DLC++T +F LAESLGGVESLIE P AMTHASTAGS Sbjct 301 AAKQMRRFGGMISVRLKGGKAAALDLCSRTEIFTLAESLGGVESLIEFPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 LEVPDDLVRLSVGIED +DL+GD+EQAL Sbjct 361 ALEVPDDLVRLSVGIEDASDLVGDIEQAL 389 >gi|54026801|ref|YP_121043.1| cystathionine gamma-synthase [Nocardia farcinica IFM 10152] gi|54018309|dbj|BAD59679.1| putative cystathionine gamma-synthase [Nocardia farcinica IFM 10152] Length=381 Score = 594 bits (1532), Expect = 6e-168, Method: Compositional matrix adjust. Identities = 285/375 (76%), Positives = 326/375 (87%), Gaps = 0/375 (0%) Query 13 GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLA 72 G +TRA+HAG+ PDP TGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTR+ALEA+LA Sbjct 5 GFSTRAVHAGFDPDPQTGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRSALEANLA 64 Query 73 AVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPV 132 A+E GA RAF+SGMAATDC LRA LRPGDH+VIPDDAYGGTFRLIDKVF++W +++TP Sbjct 65 ALESGAHGRAFASGMAATDCVLRATLRPGDHIVIPDDAYGGTFRLIDKVFSQWGIEHTPA 124 Query 133 RLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQ 192 + D DA+ AAI P T+L+WVETPTNPLLSI DI A+AE+ AK++VDNTFA+P LQ Sbjct 125 HVFDTDAMRAAIRPNTKLVWVETPTNPLLSIGDIPALAEIAHAAGAKLVVDNTFATPYLQ 184 Query 193 QPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTM 252 QPL LGADVV+HSTTKY+GGHSDVVGGAL+TND ELD F FLQNGAGAVPGPFDAYLTM Sbjct 185 QPLVLGADVVVHSTTKYLGGHSDVVGGALITNDPELDAAFGFLQNGAGAVPGPFDAYLTM 244 Query 253 RGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSV 312 RG KTL +RM+RH +NA A+A FLA HP+VS+V+YPGLP HPGH +A +QMR FGGM+SV Sbjct 245 RGTKTLAVRMERHCDNAEAIAGFLAKHPAVSTVIYPGLPEHPGHAVADKQMRRFGGMISV 304 Query 313 RMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVG 372 R+ GR AA D C++T++F LAESLGGVESLIEHP AMTHASTAGSQLEVP DLVRLSVG Sbjct 305 RLHGGRDAALDFCSRTKIFTLAESLGGVESLIEHPGAMTHASTAGSQLEVPADLVRLSVG 364 Query 373 IEDIADLLGDLEQAL 387 IED ADLL D+EQAL Sbjct 365 IEDAADLLADVEQAL 379 >gi|229491930|ref|ZP_04385750.1| cystathionine gamma-synthase [Rhodococcus erythropolis SK121] gi|229321143|gb|EEN86944.1| cystathionine gamma-synthase [Rhodococcus erythropolis SK121] Length=390 Score = 593 bits (1528), Expect = 2e-167, Method: Compositional matrix adjust. Identities = 282/389 (73%), Positives = 333/389 (86%), Gaps = 2/389 (0%) Query 1 MSEDRTGHQGIS--GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ IS G +T+A+HAGY PDP TGAVNVPIYASSTFAQDGVGG+R GFEYAR Sbjct 1 MSEQRSKADNISWQGFSTKAVHAGYEPDPLTGAVNVPIYASSTFAQDGVGGMRSGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR LEA+LAA+E G + RAFSSGMAATDC LR++LRPGDH+VIPDDAYGGTFRLI Sbjct 61 TGNPTRRPLEANLAALESGTYGRAFSSGMAATDCLLRSVLRPGDHLVIPDDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVFT+W ++YTP ++D+DAV AA+ T+L+WVETPTNPLL+I DI +AE+ + +A Sbjct 121 DKVFTQWGIEYTPAPVSDVDAVRAAMKSNTKLVWVETPTNPLLNIGDIELLAEVAHEGNA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K++VDNTFASP LQQPL+LGAD+ LHSTTKYIGGHSDVVGGALV NDEELD FAFLQNG Sbjct 181 KIVVDNTFASPYLQQPLQLGADIALHSTTKYIGGHSDVVGGALVCNDEELDTAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 +G VPGPFDA+LT+RG+KTL LRM+RHS+NA V E L HP+V+ V+YPGL SHP H++ Sbjct 241 SGGVPGPFDAFLTLRGIKTLALRMERHSDNAEKVVELLDGHPAVAGVIYPGLASHPSHKV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 AA+QMR FGGM+SVR++ G+ AA DLC++T +F LAESLGGVESLIE P AMTHASTAGS Sbjct 301 AAKQMRRFGGMISVRLKGGKAAALDLCSRTEIFTLAESLGGVESLIEFPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 LEVPDDLVRLSVGIED +DL+GD+EQAL Sbjct 361 ALEVPDDLVRLSVGIEDASDLVGDIEQAL 389 >gi|289749611|ref|ZP_06508989.1| cystathionine gamma-synthase metB [Mycobacterium tuberculosis T92] gi|289690198|gb|EFD57627.1| cystathionine gamma-synthase metB [Mycobacterium tuberculosis T92] Length=292 Score = 589 bits (1519), Expect = 3e-166, Method: Compositional matrix adjust. Identities = 291/292 (99%), Positives = 291/292 (99%), Gaps = 0/292 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG Sbjct 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK Sbjct 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV Sbjct 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG Sbjct 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPS 292 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLAD PSVSSVLYPGLPS Sbjct 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADPPSVSSVLYPGLPS 292 >gi|333921085|ref|YP_004494666.1| cystathionine gamma-synthase [Amycolicicoccus subflavus DQS3-9A1] gi|333483306|gb|AEF41866.1| Cystathionine gamma-synthase [Amycolicicoccus subflavus DQS3-9A1] Length=390 Score = 587 bits (1512), Expect = 2e-165, Method: Compositional matrix adjust. Identities = 279/377 (75%), Positives = 323/377 (86%), Gaps = 0/377 (0%) Query 12 SGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASL 71 +G +T AIHAG+ PDP TG VNVPIYASSTFAQDGVGG+RGG+EYARTGNPTR ALE +L Sbjct 14 AGFSTTAIHAGFDPDPQTGVVNVPIYASSTFAQDGVGGMRGGYEYARTGNPTRKALEDNL 73 Query 72 AAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTP 131 AA+E G + RAFSSGMAATD LRA LRPGDH+VIP+DAYGGTFRLIDKVFT W + YTP Sbjct 74 AAIEAGTYGRAFSSGMAATDALLRATLRPGDHLVIPNDAYGGTFRLIDKVFTLWGISYTP 133 Query 132 VRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPAL 191 + DLDA+ AAI P T+L+W+ETPTNPLL++ DITAIAE+ + AK +VDNTFASP L Sbjct 134 APITDLDAIRAAIRPETKLVWIETPTNPLLNVGDITAIAEIAHEAQAKFVVDNTFASPYL 193 Query 192 QQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLT 251 QQPL LGADVVLHSTTKY+GGHSDVVGGAL+T+DEELD AFLQNGAG VPGPFD +LT Sbjct 194 QQPLPLGADVVLHSTTKYLGGHSDVVGGALITDDEELDAAVAFLQNGAGGVPGPFDVFLT 253 Query 252 MRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVS 311 MRG+KTL +RM RHS+NA V ++L+ H ++SS LYPGLP HPGH++AA+QMR +GGMVS Sbjct 254 MRGIKTLAVRMDRHSDNAEKVVDYLSGHAAISSTLYPGLPEHPGHDVAAKQMRRYGGMVS 313 Query 312 VRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSV 371 +R++ GR AA D+CA+T+VF LAESLGGVESLIEHP AMTHASTAGS LEVPDDLVRLSV Sbjct 314 IRLKGGRAAALDMCARTKVFTLAESLGGVESLIEHPGAMTHASTAGSLLEVPDDLVRLSV 373 Query 372 GIEDIADLLGDLEQALG 388 GIED DL+ DLEQALG Sbjct 374 GIEDAEDLIADLEQALG 390 >gi|311742688|ref|ZP_07716497.1| cystathionine beta-lyase [Aeromicrobium marinum DSM 15272] gi|311314316|gb|EFQ84224.1| cystathionine beta-lyase [Aeromicrobium marinum DSM 15272] Length=382 Score = 582 bits (1501), Expect = 3e-164, Method: Compositional matrix adjust. Identities = 288/387 (75%), Positives = 326/387 (85%), Gaps = 6/387 (1%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MSE R G ATRAIHAG+ PDP TGAVNVPIYASSTFAQDGVGG+RGG+EYARTG Sbjct 1 MSERRRGF------ATRAIHAGHEPDPLTGAVNVPIYASSTFAQDGVGGMRGGYEYARTG 54 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR ALEA+LAA+E GA RAFSSGMAATDCALR++LRPGDH+VIPDDAYGGTFRL+DK Sbjct 55 NPTRTALEANLAALEGGAHGRAFSSGMAATDCALRSLLRPGDHLVIPDDAYGGTFRLVDK 114 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 VF++W V +TPV + D+DAV AA+TP TR +W+ETPTNPLL+I D+ A+AE+ ++ Sbjct 115 VFSQWGVTHTPVAVGDVDAVRAALTPTTRAVWIETPTNPLLNIGDVEALAEVTRRAGIRL 174 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 +VDNTFASP LQQPL LGADVVLHSTTKYIGGHSDVVGG LVT+D ELD FAFLQNGAG Sbjct 175 VVDNTFASPYLQQPLALGADVVLHSTTKYIGGHSDVVGGVLVTDDPELDAAFAFLQNGAG 234 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 VPGPFDA+LT+RG KTL +RM++H NA AV + L H +V+SVLYPGLP HPGH +AA Sbjct 235 GVPGPFDAFLTLRGAKTLAVRMEQHCTNAEAVVDLLQGHRAVASVLYPGLPEHPGHAVAA 294 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 RQMR FGGMVS+R+ GR AA DLC +T VF LAESLGG+ESLIEHP AMTHASTAGS L Sbjct 295 RQMRRFGGMVSLRLAGGREAALDLCRRTEVFTLAESLGGIESLIEHPGAMTHASTAGSAL 354 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQAL 387 EVPDDLVRLSVGIED ADLL DLEQAL Sbjct 355 EVPDDLVRLSVGIEDTADLLADLEQAL 381 >gi|296140834|ref|YP_003648077.1| cystathionine gamma-synthase [Tsukamurella paurometabola DSM 20162] gi|296028968|gb|ADG79738.1| Cystathionine gamma-synthase [Tsukamurella paurometabola DSM 20162] Length=390 Score = 580 bits (1496), Expect = 1e-163, Method: Compositional matrix adjust. Identities = 278/390 (72%), Positives = 325/390 (84%), Gaps = 2/390 (0%) Query 1 MSEDRTG--HQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE ++ G +TRAIHAGY PDP TGAVNVPIYASSTFAQDGVGG+RGGFEYAR Sbjct 1 MSEQKSAIDKHAAQGFSTRAIHAGYEPDPLTGAVNVPIYASSTFAQDGVGGMRGGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR A EA+LAA+E+G F R F+SGMAATD LRA LRPGDH++IPDDAYGGTFRLI Sbjct 61 TGNPTRRAYEANLAAIEDGTFGRGFASGMAATDTLLRATLRPGDHLIIPDDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVF++W +++TP + D+DAV AAI P T+L+W+ETPTNPLL+I DI A+AE+ A Sbjct 121 DKVFSQWGIEHTPAPVTDVDAVRAAIRPNTKLVWIETPTNPLLNIGDIAALAEVAHAGGA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K++VDNTFASP LQ PL LGADVVLHS TKY+GGHSD VGGAL+TNDE+LD +FAFLQNG Sbjct 181 KLVVDNTFASPYLQTPLTLGADVVLHSVTKYLGGHSDTVGGALITNDEQLDTDFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 AGAVPGPFD YL +RG+KTL +RM RH +NA + +FL+ P VS+VLYPGL SHP H + Sbjct 241 AGAVPGPFDVYLALRGIKTLGVRMDRHCDNAERIVDFLSGRPEVSTVLYPGLESHPNHAV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 AA+QM+ FGGM+SVR+ GR AAQ CA+T VF LAESLGG+ESLIEHP+AMTHASTAGS Sbjct 301 AAKQMKRFGGMISVRLAGGREAAQRFCARTEVFTLAESLGGIESLIEHPAAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQALG 388 QLEVP+DLVRLSVGIEDI DL+ DLE ALG Sbjct 361 QLEVPEDLVRLSVGIEDIGDLIADLENALG 390 >gi|343925074|ref|ZP_08764606.1| cystathionine gamma-synthase/cystathionine gamma-lyase [Gordonia alkanivorans NBRC 16433] gi|343765005|dbj|GAA11532.1| cystathionine gamma-synthase/cystathionine gamma-lyase [Gordonia alkanivorans NBRC 16433] Length=390 Score = 565 bits (1456), Expect = 4e-159, Method: Compositional matrix adjust. Identities = 276/389 (71%), Positives = 318/389 (82%), Gaps = 2/389 (0%) Query 1 MSEDRTGHQGI--SGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYAR 58 MSE R+ + G +TRAIHAGY PDP TGAVNVPIYASSTFAQDGVGGLR GFEYAR Sbjct 1 MSERRSAADSVRWQGFSTRAIHAGYDPDPQTGAVNVPIYASSTFAQDGVGGLRDGFEYAR 60 Query 59 TGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLI 118 TGNPTR ALEA+LAA+E G + RAF+SGMAATDC LR+ LRPGDH+VIP+DAYGGTFRLI Sbjct 61 TGNPTRRALEANLAALEHGTYGRAFASGMAATDCLLRSTLRPGDHLVIPNDAYGGTFRLI 120 Query 119 DKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSA 178 DKVFT+W + Y+ ++D+ AV AI P T+L+W ETPTNPLL++ DI IA + + A Sbjct 121 DKVFTQWGITYSVAPVSDVAAVRDAIRPETKLVWTETPTNPLLNVGDIETIASIAHEAGA 180 Query 179 KVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNG 238 K++VDNTFASP LQQPL LGADVVLHSTTKY+GGHSDVVGGALVT+ EELDE FAFLQNG Sbjct 181 KLVVDNTFASPYLQQPLTLGADVVLHSTTKYLGGHSDVVGGALVTDSEELDEAFAFLQNG 240 Query 239 AGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEI 298 AGAVPGPFD YLTMRG KTL +RM RH +NA V EFL H + +VLYPGL +HPGH + Sbjct 241 AGAVPGPFDGYLTMRGTKTLAVRMDRHCDNAEKVVEFLNSHDKIEAVLYPGLENHPGHAV 300 Query 299 AARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGS 358 AA+QM+ +GGMVSV ++ G A+ CA+T VF LAESLGG+ESLIEHP AMTHASTAGS Sbjct 301 AAKQMKRYGGMVSVLVKGGIEEAKAFCARTEVFTLAESLGGIESLIEHPGAMTHASTAGS 360 Query 359 QLEVPDDLVRLSVGIEDIADLLGDLEQAL 387 LEVP +LVRLSVGIEDI D+LGDLE AL Sbjct 361 LLEVPANLVRLSVGIEDIDDILGDLENAL 389 >gi|326381816|ref|ZP_08203509.1| cystathionine gamma-synthase [Gordonia neofelifaecis NRRL B-59395] gi|326199242|gb|EGD56423.1| cystathionine gamma-synthase [Gordonia neofelifaecis NRRL B-59395] Length=380 Score = 551 bits (1419), Expect = 8e-155, Method: Compositional matrix adjust. Identities = 266/376 (71%), Positives = 315/376 (84%), Gaps = 0/376 (0%) Query 12 SGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASL 71 G +T+AIHAG+ PD TGAVNVPIYASSTFAQDGVGG+R GFEYARTGNPTR LEA++ Sbjct 4 QGFSTKAIHAGWDPDARTGAVNVPIYASSTFAQDGVGGMRDGFEYARTGNPTRRVLEANI 63 Query 72 AAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTP 131 AA+E G F R FSSGMAATD LRA LRPGDH+VIP+DAYGGTFRLIDKVF+ W + Y+ Sbjct 64 AALEAGRFGRGFSSGMAATDALLRATLRPGDHLVIPNDAYGGTFRLIDKVFSEWGITYSV 123 Query 132 VRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPAL 191 + D+DA+ AAITP+T+L+WVETPTNPLL++ DI A+AE+ AK++VDNTFA+P L Sbjct 124 APVVDVDAIRAAITPKTKLVWVETPTNPLLNVGDIAAVAEVAHAAGAKLVVDNTFATPYL 183 Query 192 QQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLT 251 QQPL LGADVV+HSTTKY+GGHSDVVGGA+VT+DE+LD + AFLQNGAGAVPGPFDAYLT Sbjct 184 QQPLTLGADVVVHSTTKYLGGHSDVVGGAIVTDDEQLDADIAFLQNGAGAVPGPFDAYLT 243 Query 252 MRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVS 311 MRG+KTL +RM RH +NA + F + HP + VLYPGL HPGHE AA+QMR +GGM+S Sbjct 244 MRGIKTLAVRMDRHCDNAEELVAFFSAHPKIEKVLYPGLADHPGHEAAAKQMRRYGGMIS 303 Query 312 VRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSV 371 V++ GR AA D CA+T++F LAESLGG+ESLIEHP AMTHASTAGS LEVPD+LVRLSV Sbjct 304 VQLAGGREAALDFCARTKIFTLAESLGGIESLIEHPGAMTHASTAGSLLEVPDNLVRLSV 363 Query 372 GIEDIADLLGDLEQAL 387 GIED+ DLL D+ QAL Sbjct 364 GIEDVDDLLEDVRQAL 379 >gi|256374851|ref|YP_003098511.1| cystathionine gamma-synthase [Actinosynnema mirum DSM 43827] gi|255919154|gb|ACU34665.1| Cystathionine gamma-synthase [Actinosynnema mirum DSM 43827] Length=383 Score = 548 bits (1413), Expect = 5e-154, Method: Compositional matrix adjust. Identities = 265/379 (70%), Positives = 315/379 (84%), Gaps = 3/379 (0%) Query 12 SGP---ATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALE 68 SGP ATRAIH G PDP TGAV P+YA+ST+AQDGVGGLR GFEY+RTGNPTR ALE Sbjct 4 SGPLGFATRAIHTGQEPDPTTGAVIPPLYATSTYAQDGVGGLRKGFEYSRTGNPTRTALE 63 Query 69 ASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQ 128 LAA+E G F RAF+SGMAATD ALR++LRPGDH+VIP+D YGGTFRLIDKV ++W V+ Sbjct 64 QCLAALEGGRFGRAFASGMAATDTALRSLLRPGDHLVIPNDTYGGTFRLIDKVLSQWGVE 123 Query 129 YTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFAS 188 +TPV ++D+DAV AAI P T+L+WVETPTNPLL+IADI +A+ D S ++VDNTFAS Sbjct 124 HTPVAISDVDAVRAAIRPNTKLVWVETPTNPLLTIADIALLADATRDASVTLVVDNTFAS 183 Query 189 PALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDA 248 P LQ PL LGADVV+HSTTKY+GGHSD++GGALVT+DEELD +FAFLQNG+GAVP PFDA Sbjct 184 PYLQNPLELGADVVMHSTTKYLGGHSDLIGGALVTSDEELDTKFAFLQNGSGAVPSPFDA 243 Query 249 YLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGG 308 +LT+R LKTL +RM++HS+NA AVA+ L+ HP V VLYPGLP HPGHE AA+QMR FGG Sbjct 244 WLTLRSLKTLQVRMEKHSDNAEAVAQALSAHPKVERVLYPGLPEHPGHETAAKQMRRFGG 303 Query 309 MVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVR 368 MVS ++ G +AA D+CA+T VF LAESLGGVESLIEHP MTHAS AG++LEVP LVR Sbjct 304 MVSFLVKGGEQAALDVCARTNVFTLAESLGGVESLIEHPGRMTHASVAGTELEVPASLVR 363 Query 369 LSVGIEDIADLLGDLEQAL 387 +SVG+ED DL+ DL QAL Sbjct 364 ISVGLEDADDLIADLSQAL 382 >gi|262201574|ref|YP_003272782.1| cystathionine gamma-synthase [Gordonia bronchialis DSM 43247] gi|262084921|gb|ACY20889.1| Cystathionine gamma-synthase [Gordonia bronchialis DSM 43247] Length=383 Score = 548 bits (1411), Expect = 8e-154, Method: Compositional matrix adjust. Identities = 265/363 (74%), Positives = 303/363 (84%), Gaps = 0/363 (0%) Query 12 SGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASL 71 +G +TRAIHAGY PDP TGAVNVPIYASSTFAQDGVGGLR GFEYARTGNPTR ALEA+L Sbjct 7 TGFSTRAIHAGYEPDPQTGAVNVPIYASSTFAQDGVGGLRQGFEYARTGNPTRRALEANL 66 Query 72 AAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTP 131 AA+E G RAF SGMAATD LRA LRPGDH+VIP+DAYGGTFRLIDKVFT+W + Y+ Sbjct 67 AALENGTHGRAFGSGMAATDTLLRATLRPGDHLVIPNDAYGGTFRLIDKVFTQWGITYSV 126 Query 132 VRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPAL 191 + D+DAV AAI P T+L+W ETPTNPLL++ DI A+A + D AK++VDNTFASP L Sbjct 127 APVTDVDAVRAAIRPETKLVWTETPTNPLLNVGDIEALASVAHDAGAKLVVDNTFASPYL 186 Query 192 QQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLT 251 QQPL LGADVVLHSTTKY+GGHSDVVGGAL+T+ ELDE FAFLQNGAGAVPGPFD YLT Sbjct 187 QQPLSLGADVVLHSTTKYLGGHSDVVGGALITDSTELDEAFAFLQNGAGAVPGPFDGYLT 246 Query 252 MRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVS 311 +RG+KTL +RM RH +NA V EFL+ H + +VLYPGL +HPGH AA+QM+ FGGMVS Sbjct 247 LRGIKTLAVRMDRHCDNAEKVVEFLSGHDKIDAVLYPGLSTHPGHGAAAKQMKRFGGMVS 306 Query 312 VRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSV 371 V ++ G AAQ CA+T VF LAESLGG+ESLIEHP AMTHASTAGS LEVP++LVRLSV Sbjct 307 VLVKDGMDAAQKFCARTEVFTLAESLGGIESLIEHPGAMTHASTAGSLLEVPENLVRLSV 366 Query 372 GIE 374 GIE Sbjct 367 GIE 369 >gi|237785421|ref|YP_002906126.1| cystathionine gamma-synthase [Corynebacterium kroppenstedtii DSM 44385] gi|237758333|gb|ACR17583.1| cystathionine gamma-synthase [Corynebacterium kroppenstedtii DSM 44385] Length=387 Score = 544 bits (1401), Expect = 1e-152, Method: Compositional matrix adjust. Identities = 261/387 (68%), Positives = 319/387 (83%), Gaps = 1/387 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MS+ G G T A+HAG+ P+ ATGAVN PIYA+ST+AQDGVGGLRGG+EY+RTG Sbjct 1 MSDIEKGDARDRGLETSAVHAGWTPEAATGAVNPPIYATSTYAQDGVGGLRGGYEYSRTG 60 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR ALE ++A +E G + RAF SGMAA+D LRAML+PGDH++IP+DAYGGTFRLIDK Sbjct 61 NPTRTALEKAIAELERGKYGRAFGSGMAASDAVLRAMLKPGDHIIIPNDAYGGTFRLIDK 120 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 +F +W + YTPV + DLD V +A+T RTRL+W E+PTNPLL+IADI A+A++ +A++ Sbjct 121 IFAKWGIDYTPVAINDLDEVQSALTDRTRLVWAESPTNPLLTIADIPALAKVAHSVNARL 180 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 +VDNTFA+PALQQPL LGAD+V+HSTTKYIGGHSDVVGGA+VT+D+E+D+E AFLQN AG Sbjct 181 VVDNTFATPALQQPLSLGADIVVHSTTKYIGGHSDVVGGAVVTSDQEVDDEVAFLQNSAG 240 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 A+ GPFD++LT+RGL++L +RM+RHS NA A+A LADHP+V V+YPGL SHPGH +AA Sbjct 241 AIAGPFDSFLTLRGLRSLPVRMERHSANAQAIANRLADHPAVKEVIYPGLESHPGHAVAA 300 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 QM FGGMVS+R+ A AAQ LC T VF LAESLGGVESLIEHP+AMTHASTAGS L Sbjct 301 AQMSHFGGMVSLRL-ADHDAAQRLCKNTSVFTLAESLGGVESLIEHPAAMTHASTAGSVL 359 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQAL 387 EVPDDLVRLSVG+E DL+ DL QAL Sbjct 360 EVPDDLVRLSVGLESAEDLIADLLQAL 386 >gi|134097500|ref|YP_001103161.1| cystathionine gamma-synthase [Saccharopolyspora erythraea NRRL 2338] gi|291009359|ref|ZP_06567332.1| cystathionine gamma-synthase [Saccharopolyspora erythraea NRRL 2338] gi|133910123|emb|CAM00236.1| cystathionine gamma-synthase [Saccharopolyspora erythraea NRRL 2338] Length=379 Score = 530 bits (1366), Expect = 1e-148, Method: Compositional matrix adjust. Identities = 261/375 (70%), Positives = 305/375 (82%), Gaps = 0/375 (0%) Query 13 GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLA 72 G ATRAIHAG DP TG+V VPI+A+ST+AQDGVGG+R G+EY+RTGNPTR ALE LA Sbjct 4 GFATRAIHAGQDADPTTGSVIVPIHATSTYAQDGVGGMRSGYEYSRTGNPTRTALEECLA 63 Query 73 AVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPV 132 A+E G ARAF+SGMAATD LRA LRPGDH++IPDDAYGGTFRLIDKV + W V+YTPV Sbjct 64 ALEGGRHARAFASGMAATDAVLRATLRPGDHLIIPDDAYGGTFRLIDKVLSGWGVEYTPV 123 Query 133 RLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQ 192 ++D+DA AAI T+LIW+ETPTNPLL+I DI A+A+L D K++VDNTFASP LQ Sbjct 124 PVSDVDAARAAIRANTKLIWIETPTNPLLNIGDIAALAQLAHDTGTKLVVDNTFASPYLQ 183 Query 193 QPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTM 252 QPL LGA VV+HSTTKY+GGHSDVVGGA+VT+D+EL ++ AFLQN AGAVPGPFDA+LT+ Sbjct 184 QPLELGAAVVVHSTTKYLGGHSDVVGGAVVTSDDELAQQVAFLQNSAGAVPGPFDAWLTL 243 Query 253 RGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSV 312 RGLKTL +RM RHS NA V L +HP V+ VLYPGL HPGH++A +QMR FGGMVS Sbjct 244 RGLKTLAVRMDRHSANAERVVAALQNHPKVARVLYPGLEEHPGHDVAVKQMRSFGGMVSF 303 Query 313 RMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVG 372 G +AA D+CA+TR+F LAESLGGVESLIEHP MTHASTAGS L+VP DLVRLSVG Sbjct 304 IHADGEQAALDVCARTRLFTLAESLGGVESLIEHPGRMTHASTAGSMLQVPSDLVRLSVG 363 Query 373 IEDIADLLGDLEQAL 387 IED DL+ DL AL Sbjct 364 IEDAGDLVEDLLSAL 378 >gi|331694805|ref|YP_004331044.1| Cys/Met metabolism pyridoxal-phosphate-dependent protein [Pseudonocardia dioxanivorans CB1190] gi|326949494|gb|AEA23191.1| Cys/Met metabolism pyridoxal-phosphate-dependent protein [Pseudonocardia dioxanivorans CB1190] Length=382 Score = 520 bits (1340), Expect = 1e-145, Method: Compositional matrix adjust. Identities = 256/377 (68%), Positives = 303/377 (81%), Gaps = 0/377 (0%) Query 11 ISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEAS 70 + G +T AIHAG PDP TGAV VPI+ SSTFAQDGVGG R G+EY+R+ NPTR AL+ Sbjct 1 MRGFSTNAIHAGQEPDPTTGAVIVPIHPSSTFAQDGVGGTRNGYEYSRSANPTRTALQEC 60 Query 71 LAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYT 130 LAA+E G A AF SGM A+D LR ++RPGDHVVIP DAYGGTFRL+DK+ T+W V+Y+ Sbjct 61 LAALEGGRHAFAFGSGMGASDVLLRVLVRPGDHVVIPHDAYGGTFRLVDKILTQWGVEYS 120 Query 131 PVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPA 190 V LAD+DA+ AA+ P TR++W ETPTNPLL +ADI A+A++ A+++VDNTFASP Sbjct 121 TVDLADVDALRAALRPTTRVVWCETPTNPLLGVADIAALADVTRGTEARLVVDNTFASPY 180 Query 191 LQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYL 250 LQ PL LGADVVLHSTTKY+GGHSDVVGGALVT+D+ L E+ AF QN G+VPGPFD +L Sbjct 181 LQTPLALGADVVLHSTTKYVGGHSDVVGGALVTSDDGLAEQLAFTQNSVGSVPGPFDTWL 240 Query 251 TMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMV 310 T+RG+KTL +RM+RH +NA VAE LA HP+V+ V YPGL SHPGHE+AA+QMR FGGMV Sbjct 241 TLRGVKTLAVRMERHCDNAERVAEMLAAHPAVAQVCYPGLESHPGHEVAAKQMRRFGGMV 300 Query 311 SVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLS 370 S R+ AGR AA +CA T +F LAESLGGVESLIEHP AMTHAS AGS LEVPDDLVRLS Sbjct 301 SFRVAAGREAALAVCAGTELFTLAESLGGVESLIEHPGAMTHASVAGSALEVPDDLVRLS 360 Query 371 VGIEDIADLLGDLEQAL 387 VGIED+ DLL DL AL Sbjct 361 VGIEDVDDLLEDLRGAL 377 >gi|325003216|ref|ZP_08124328.1| cystathionine gamma-synthase [Pseudonocardia sp. P1] Length=381 Score = 516 bits (1330), Expect = 2e-144, Method: Compositional matrix adjust. Identities = 256/377 (68%), Positives = 296/377 (79%), Gaps = 0/377 (0%) Query 11 ISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEAS 70 + G +TRAIHAG PDP TGAV I+ SSTFAQDGVGG RGG+EY+R+ NPTR L+ Sbjct 1 MQGFSTRAIHAGQEPDPTTGAVTTSIHTSSTFAQDGVGGTRGGYEYSRSANPTRTVLQEC 60 Query 71 LAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYT 130 LAA+E G A AF SGM ATD LR +LRPGDH+VIP DAYGGTFRL+DKV + ++YT Sbjct 61 LAALEGGRHAHAFGSGMGATDTLLRILLRPGDHIVIPHDAYGGTFRLVDKVLSGTGIEYT 120 Query 131 PVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPA 190 PV L DLDA AAI P T++IW ETPTNPLL IADI +A + + A+++VDNTFASP Sbjct 121 PVDLGDLDATRAAIRPATKVIWSETPTNPLLGIADIAGLAGVAREAGARLVVDNTFASPY 180 Query 191 LQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYL 250 LQ PL LGADVV+HSTTKY+GGHSDVVGGALVT+D EL E +F QN G+VPGPFDA+L Sbjct 181 LQTPLALGADVVVHSTTKYVGGHSDVVGGALVTDDGELAERISFTQNSVGSVPGPFDAWL 240 Query 251 TMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMV 310 T+RG KTL +RM+RH +NA V E L HP+V+SVLYPGLPSHPGHE+AA+QMR FGGMV Sbjct 241 TLRGAKTLAVRMERHCDNAERVTEMLGSHPAVASVLYPGLPSHPGHEVAAKQMRRFGGMV 300 Query 311 SVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLS 370 S GR AA +CA+TR+F LAESLGGVESLIEHP MTHASTAGS LEVPD+LVRLS Sbjct 301 SFLAAGGRDAALRICAETRLFTLAESLGGVESLIEHPGQMTHASTAGSMLEVPDNLVRLS 360 Query 371 VGIEDIADLLGDLEQAL 387 VGIED DLL DL AL Sbjct 361 VGIEDADDLLEDLRTAL 377 >gi|302530128|ref|ZP_07282470.1| methionine gamma-lyase [Streptomyces sp. AA4] gi|302439023|gb|EFL10839.1| methionine gamma-lyase [Streptomyces sp. AA4] Length=385 Score = 511 bits (1317), Expect = 6e-143, Method: Compositional matrix adjust. Identities = 249/379 (66%), Positives = 306/379 (81%), Gaps = 1/379 (0%) Query 11 ISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLR-GGFEYARTGNPTRAALEA 69 + G TRAIHAG +PDP TGAV VPIY +ST+AQDGVGG R GG+EY+RT NPTR ALE Sbjct 7 VLGFETRAIHAGQQPDPRTGAVIVPIYQTSTYAQDGVGGTREGGYEYSRTANPTRTALEE 66 Query 70 SLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQY 129 +LA++E AF+SGMAA+D LR +LRPGDH+V+ +DAYGGTFRLIDKV + W V++ Sbjct 67 ALASLEGARHTLAFASGMAASDAVLRTVLRPGDHLVLGNDAYGGTFRLIDKVLSLWGVEH 126 Query 130 TPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASP 189 T L+ +D V AA+ P T+LIW E+PTNPLL IADI A+A + D A+++VDNTFA+P Sbjct 127 TVADLSRIDEVRAAMRPETKLIWCESPTNPLLGIADIAALAGVAHDAGARLVVDNTFATP 186 Query 190 ALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAY 249 LQ PL LGAD+V+HSTTKY+GGHSDVVGGA+VTN++EL E+ +L+N AGAVPGPFDA+ Sbjct 187 YLQTPLALGADIVVHSTTKYLGGHSDVVGGAVVTNEDELREQLFYLRNAAGAVPGPFDAW 246 Query 250 LTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGM 309 LT+RGLKTL LRM+RHS+NA VA LA HP V+ V YPGLP HPGHE+AA+QMR FGGM Sbjct 247 LTLRGLKTLALRMERHSDNADLVARTLAKHPKVTKVYYPGLPEHPGHEVAAKQMRRFGGM 306 Query 310 VSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRL 369 VS R+ G AA ++ ++T++F+LAESLGG+ESLIEHP MTHASTAGS LEVP+DL+RL Sbjct 307 VSFRVEGGEEAALEVASRTKLFVLAESLGGIESLIEHPGKMTHASTAGSTLEVPEDLIRL 366 Query 370 SVGIEDIADLLGDLEQALG 388 SVGIED DL+ DL QALG Sbjct 367 SVGIEDGRDLVADLTQALG 385 >gi|300789918|ref|YP_003770209.1| cystathionine gamma-synthase [Amycolatopsis mediterranei U32] gi|299799432|gb|ADJ49807.1| cystathionine gamma-synthase [Amycolatopsis mediterranei U32] gi|340531589|gb|AEK46794.1| cystathionine gamma-synthase [Amycolatopsis mediterranei S699] Length=385 Score = 510 bits (1314), Expect = 1e-142, Method: Compositional matrix adjust. Identities = 250/379 (66%), Positives = 306/379 (81%), Gaps = 1/379 (0%) Query 11 ISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLR-GGFEYARTGNPTRAALEA 69 + G TRAIHAG +PDP TGAV VPIY +ST+AQDGVGG R G +EY+RT NPTR+ALE Sbjct 7 VLGFETRAIHAGQKPDPRTGAVTVPIYQTSTYAQDGVGGTREGDYEYSRTANPTRSALEE 66 Query 70 SLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQY 129 +LA++E G A AF+SGMAA+D LR+ LRPGDH+V+ +DAYGGTFRLIDKV + W V++ Sbjct 67 ALASLEGGRHALAFASGMAASDVVLRSTLRPGDHLVLGNDAYGGTFRLIDKVLSLWGVEH 126 Query 130 TPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASP 189 T LADLD V AAI P T+LIW E+PTNP+L IADI A+A + D A+++VDNTFA+P Sbjct 127 TVADLADLDEVRAAIRPETKLIWCESPTNPMLGIADIAALAGVAHDAGARLVVDNTFATP 186 Query 190 ALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAY 249 LQ PL LGAD+VLHSTTKY+GGH+DVVGGA++TN++EL E+F FL+N AGAVPGPFDA+ Sbjct 187 YLQNPLALGADIVLHSTTKYLGGHADVVGGAIITNEDELREQFFFLRNTAGAVPGPFDAW 246 Query 250 LTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGM 309 LT+RG+KTL LRM+RHS+NA + + L HP V+ V YPGLP HPGHE AA+QMR FGGM Sbjct 247 LTLRGVKTLALRMERHSDNAEKIVQALIKHPKVTKVYYPGLPEHPGHETAAKQMRRFGGM 306 Query 310 VSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRL 369 VS R G +AA ++ ++T++FILAESLGGVESLIEHP MTHASTAGS L+VP DL+RL Sbjct 307 VSFRHVDGEQAALEVASRTKLFILAESLGGVESLIEHPGKMTHASTAGSTLQVPADLLRL 366 Query 370 SVGIEDIADLLGDLEQALG 388 SVGIED DL+ DL ALG Sbjct 367 SVGIEDGRDLVADLLAALG 385 >gi|302536473|ref|ZP_07288815.1| methionine gamma-lyase [Streptomyces sp. C] gi|302445368|gb|EFL17184.1| methionine gamma-lyase [Streptomyces sp. C] Length=385 Score = 507 bits (1306), Expect = 1e-141, Method: Compositional matrix adjust. Identities = 247/388 (64%), Positives = 297/388 (77%), Gaps = 3/388 (0%) Query 1 MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG 60 MS+D HQ TRAIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ Sbjct 1 MSDDSHEHQSFE---TRAIHAGNTADPQTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSA 57 Query 61 NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK 120 NPTR ALE +LAA+E G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL K Sbjct 58 NPTRTALEENLAALEGGRRGLAFASGLAAEDCLLRTLLSPGDHVVIPNDAYGGTFRLFAK 117 Query 121 VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV 180 V +RW V+++ +D D+V AAITP+T++IWVETP+NPLL I DI A++ + AK+ Sbjct 118 VVSRWGVEWSVADTSDADSVRAAITPKTKVIWVETPSNPLLGITDIAMTAQIAREAGAKL 177 Query 181 LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG 240 +VDNTFASP LQQPL LGADVV+HS TKY+GGHSDVVGGALVT DE L EE A+ QN G Sbjct 178 VVDNTFASPYLQQPLALGADVVVHSLTKYMGGHSDVVGGALVTADEALGEELAYHQNAMG 237 Query 241 AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA 300 AV GPFD+++ +RG+KTL +RM RH+ENA + E L HP V++VLYPGLP HPGHEIAA Sbjct 238 AVAGPFDSWVVLRGIKTLAVRMDRHAENAAKIVEVLKRHPKVTTVLYPGLPEHPGHEIAA 297 Query 301 RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL 360 +QMR FGGMVS ++ G A +C +T++F LAESLGGVESLIEHP MTHAS AGS L Sbjct 298 KQMRNFGGMVSFQVAGGEEEAVAVCGRTKIFTLAESLGGVESLIEHPGRMTHASVAGSAL 357 Query 361 EVPDDLVRLSVGIEDIADLLGDLEQALG 388 EVP DL+R+SVGIE+ DL+ DL QALG Sbjct 358 EVPADLIRVSVGIENADDLVADLVQALG 385 >gi|328884660|emb|CCA57899.1| Cystathionine gamma-lyase [Streptomyces venezuelae ATCC 10712] Length=384 Score = 505 bits (1301), Expect = 4e-141, Method: Compositional matrix adjust. Identities = 247/385 (65%), Positives = 293/385 (77%), Gaps = 3/385 (0%) Query 4 DRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPT 63 D+ HQ TRAIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPT Sbjct 3 DQHSHQSFE---TRAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPT 59 Query 64 RAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFT 123 R ALE +LAA+E G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL KV Sbjct 60 RTALEENLAALEGGRRGLAFASGLAAEDCLLRTLLVPGDHVVIPNDAYGGTFRLFAKVVE 119 Query 124 RWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVD 183 RW V ++ +D+DAV AA+ RT+LIWVETP+NPLL I DI AIA + K++VD Sbjct 120 RWGVDFSVANTSDVDAVRAAVNDRTKLIWVETPSNPLLGITDIEAIAGVARQAGVKLVVD 179 Query 184 NTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVP 243 NTFASP LQQPL LGADVV+HS TKY+GGHSDVVGGALVT DE L EE A+ QN GAV Sbjct 180 NTFASPYLQQPLALGADVVVHSLTKYMGGHSDVVGGALVTADEALGEELAYHQNAMGAVA 239 Query 244 GPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQM 303 GPFD+++ +RG+KTL +RM RHSENA + E L HP V+ VLYPGLP HPGHE+AA+QM Sbjct 240 GPFDSWIVLRGIKTLAVRMDRHSENAEKIVEMLTQHPKVTQVLYPGLPEHPGHEVAAKQM 299 Query 304 RGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVP 363 + FGGM+S R++ G +AA ++C + ++F L ESLGGVESLIEHP MTHAS AGS LEVP Sbjct 300 KSFGGMISFRVQGGEQAAVEVCNRAQLFTLGESLGGVESLIEHPGRMTHASVAGSALEVP 359 Query 364 DDLVRLSVGIEDIADLLGDLEQALG 388 DLVRLSVGIE++ DLL DL QALG Sbjct 360 ADLVRLSVGIENVDDLLADLRQALG 384 >gi|326776996|ref|ZP_08236261.1| Cys/Met metabolism pyridoxal-phosphate-dependent protein [Streptomyces cf. griseus XylebKG-1] gi|326657329|gb|EGE42175.1| Cys/Met metabolism pyridoxal-phosphate-dependent protein [Streptomyces griseus XylebKG-1] Length=381 Score = 504 bits (1298), Expect = 9e-141, Method: Compositional matrix adjust. Identities = 247/373 (67%), Positives = 292/373 (79%), Gaps = 0/373 (0%) Query 16 TRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVE 75 T AIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPTR ALE +LAA+E Sbjct 9 TLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALE 68 Query 76 EGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA 135 G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL KV +RW V+++ + Sbjct 69 GGRRGLAFASGLAAEDCLLRTLLTPGDHVVIPNDAYGGTFRLFAKVASRWGVEFSVADTS 128 Query 136 DLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPL 195 D+ AV AAITPRTR +WVETP+NPLL I DI A+A++ D A+++VDNTFASP LQQPL Sbjct 129 DVAAVRAAITPRTRAVWVETPSNPLLGITDIAAVAQVAHDAGARLVVDNTFASPYLQQPL 188 Query 196 RLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGL 255 LGADVV+HSTTKY+GGHSDVVGGALV +D EL EE A+ QN GAV GPFDA+L +RG+ Sbjct 189 ALGADVVVHSTTKYMGGHSDVVGGALVVSDPELAEELAYHQNAMGAVAGPFDAWLVLRGI 248 Query 256 KTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMR 315 KTL +RM RH+ENA VA+ L HP VS VLYPGLP HPGHE+AA+QM+ FGGMVS R+ Sbjct 249 KTLAVRMDRHTENATKVADLLTRHPKVSQVLYPGLPEHPGHEVAAKQMKAFGGMVSFRVA 308 Query 316 AGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIED 375 G AA ++C + ++F L ESLGGVESL+EHP MTHAS AGS LEVP DLVRLSVGIE+ Sbjct 309 GGEEAAVEVCNRAKLFTLGESLGGVESLLEHPGRMTHASAAGSPLEVPADLVRLSVGIEN 368 Query 376 IADLLGDLEQALG 388 DLL DL QALG Sbjct 369 GDDLLADLAQALG 381 >gi|344044527|gb|EGV40203.1| cystathionine gamma-synthase [Corynebacterium glutamicum S9114] Length=386 Score = 504 bits (1297), Expect = 1e-140, Method: Compositional matrix adjust. Identities = 240/376 (64%), Positives = 289/376 (77%), Gaps = 0/376 (0%) Query 13 GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLA 72 G +T +IHAGY PD G++N PIYAS+TFAQ+ LR G+EY R GNPT ALE ++A Sbjct 9 GFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTIVALEQTVA 68 Query 73 AVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPV 132 A+E + RAFSSGMAATD R +L+PGDH+V+ +DAYGGT+RLID VFT W V+YT V Sbjct 69 ALEGAKYGRAFSSGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVV 128 Query 133 RLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQ 192 + ++ V AAI T+LIWVETPTNP L I DI AIA+L +AK++VDNTFASP LQ Sbjct 129 DTSVVEEVKAAIKDNTKLIWVETPTNPALGITDIEAIAKLTEGTNAKLVVDNTFASPYLQ 188 Query 193 QPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTM 252 QPL+LGA VLHSTTKYIGGHSDVVGG +VTND+E+DEE F+Q G G +P FDAYLT Sbjct 189 QPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSVFDAYLTA 248 Query 253 RGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSV 312 RGLKTL +RM RH +NA +AEFL P VS+VLYPGL +HPGHE+AA+QM+ FGGM+SV Sbjct 249 RGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRFGGMISV 308 Query 313 RMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVG 372 R G AA+ C T++ LAESLGGVESL+EHP+ MTH S AGSQLEVP DLVR+S+G Sbjct 309 RFAGGEEAAKKFCTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPRDLVRISIG 368 Query 373 IEDIADLLGDLEQALG 388 IEDI DLL D+EQAL Sbjct 369 IEDIEDLLADVEQALN 384 >gi|182436372|ref|YP_001824091.1| cystathionine gamma-synthase [Streptomyces griseus subsp. griseus NBRC 13350] gi|178464888|dbj|BAG19408.1| putative cystathionine gamma-synthase [Streptomyces griseus subsp. griseus NBRC 13350] Length=381 Score = 503 bits (1296), Expect = 2e-140, Method: Compositional matrix adjust. Identities = 246/373 (66%), Positives = 292/373 (79%), Gaps = 0/373 (0%) Query 16 TRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVE 75 T AIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPTR ALE +LAA+E Sbjct 9 TLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALE 68 Query 76 EGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA 135 G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL KV +RW V+++ + Sbjct 69 GGRRGLAFASGLAAEDCLLRTLLTPGDHVVIPNDAYGGTFRLFAKVASRWGVEFSVADTS 128 Query 136 DLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPL 195 D+ AV AAITPRT+ +WVETP+NPLL I DI A+A++ D A+++VDNTFASP LQQPL Sbjct 129 DVAAVRAAITPRTKAVWVETPSNPLLGITDIAAVAQVAHDAGARLVVDNTFASPYLQQPL 188 Query 196 RLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGL 255 LGADVV+HSTTKY+GGHSDVVGGALV +D EL EE A+ QN GAV GPFDA+L +RG+ Sbjct 189 ALGADVVVHSTTKYMGGHSDVVGGALVVSDPELAEELAYHQNAMGAVAGPFDAWLVLRGI 248 Query 256 KTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMR 315 KTL +RM RH+ENA VA+ L HP VS VLYPGLP HPGHE+AA+QM+ FGGMVS R+ Sbjct 249 KTLAVRMDRHTENATKVADLLTRHPKVSQVLYPGLPEHPGHEVAAKQMKAFGGMVSFRVA 308 Query 316 AGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIED 375 G AA ++C + ++F L ESLGGVESL+EHP MTHAS AGS LEVP DLVRLSVGIE+ Sbjct 309 GGEEAAVEVCNRAKLFTLGESLGGVESLLEHPGRMTHASAAGSPLEVPADLVRLSVGIEN 368 Query 376 IADLLGDLEQALG 388 DLL DL QALG Sbjct 369 GDDLLADLAQALG 381 >gi|19553642|ref|NP_601644.1| cystathionine gamma-synthase [Corynebacterium glutamicum ATCC 13032] gi|62391286|ref|YP_226688.1| cystathionine gamma-synthase [Corynebacterium glutamicum ATCC 13032] gi|5852462|gb|AAD54070.1|AF126953_1 cystathionine gamma-synthase [Corynebacterium glutamicum] gi|21325217|dbj|BAB99839.1| Cystathionine beta-lyases/cystathionine gamma-synthases [Corynebacterium glutamicum ATCC 13032] gi|41326626|emb|CAF21108.1| Cystathionine gamma-Synthase [Corynebacterium glutamicum ATCC 13032] Length=386 Score = 503 bits (1295), Expect = 2e-140, Method: Compositional matrix adjust. Identities = 239/376 (64%), Positives = 289/376 (77%), Gaps = 0/376 (0%) Query 13 GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLA 72 G +T +IHAGY PD G++N PIYAS+TFAQ+ LR G+EY R GNPT ALE ++A Sbjct 9 GFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTIVALEQTVA 68 Query 73 AVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPV 132 A+E + RAFSSGMAATD R +L+PGDH+V+ +DAYGGT+RLID VFT W V+YT V Sbjct 69 ALEGAKYGRAFSSGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVV 128 Query 133 RLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQ 192 + ++ V AAI T+LIWVETPTNP L I DI A+A+L +AK++VDNTFASP LQ Sbjct 129 DTSVVEEVKAAIKDNTKLIWVETPTNPALGITDIEAVAKLTEGTNAKLVVDNTFASPYLQ 188 Query 193 QPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTM 252 QPL+LGA VLHSTTKYIGGHSDVVGG +VTND+E+DEE F+Q G G +P FDAYLT Sbjct 189 QPLKLGAHAVLHSTTKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSVFDAYLTA 248 Query 253 RGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSV 312 RGLKTL +RM RH +NA +AEFL P VS+VLYPGL +HPGHE+AA+QM+ FGGM+SV Sbjct 249 RGLKTLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRFGGMISV 308 Query 313 RMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVG 372 R G AA+ C T++ LAESLGGVESL+EHP+ MTH S AGSQLEVP DLVR+S+G Sbjct 309 RFAGGEEAAKKFCTSTKLICLAESLGGVESLLEHPATMTHQSAAGSQLEVPRDLVRISIG 368 Query 373 IEDIADLLGDLEQALG 388 IEDI DLL D+EQAL Sbjct 369 IEDIEDLLADVEQALN 384 >gi|21223331|ref|NP_629110.1| cystathionine gamma-synthase [Streptomyces coelicolor A3(2)] gi|289769461|ref|ZP_06528839.1| cystathionine gamma-synthase [Streptomyces lividans TK24] gi|20520959|emb|CAD30944.1| cystathionine gamma-synthase [Streptomyces coelicolor A3(2)] gi|289699660|gb|EFD67089.1| cystathionine gamma-synthase [Streptomyces lividans TK24] Length=386 Score = 503 bits (1294), Expect = 3e-140, Method: Compositional matrix adjust. Identities = 244/373 (66%), Positives = 292/373 (79%), Gaps = 0/373 (0%) Query 16 TRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVE 75 T AIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPTR ALE +LAA+E Sbjct 14 TLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALE 73 Query 76 EGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA 135 G AF+SG+AA DC LR +LRPGDHVVIP+DAYGGTFRL KV TRW V+++ + Sbjct 74 GGRRGLAFASGLAAEDCLLRTLLRPGDHVVIPNDAYGGTFRLFAKVATRWGVEWSVADTS 133 Query 136 DLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPL 195 D AV AA+TP+T+ +WVETP+NPLL I DI +A++ D A+++VDNTFA+P LQQPL Sbjct 134 DAAAVRAALTPKTKAVWVETPSNPLLGITDIAQVAQVARDAGARLVVDNTFATPYLQQPL 193 Query 196 RLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGL 255 LGADVV+HS TKY+GGHSDVVGGAL+ D+EL EE AF QN GAV GPFD++L +RG Sbjct 194 ALGADVVVHSLTKYMGGHSDVVGGALIVGDQELGEELAFHQNAMGAVAGPFDSWLVLRGT 253 Query 256 KTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMR 315 KTL +RM RHSENA VA+ L+ H V+SVLYPGLP HPGHE+AA+QM+ FGGMVS R+ Sbjct 254 KTLAVRMDRHSENATKVADMLSRHARVTSVLYPGLPEHPGHEVAAKQMKAFGGMVSFRVE 313 Query 316 AGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIED 375 G +AA ++C + +VF L ESLGGVESLIEHP MTHAS AGS LEVP DLVRLSVGIE+ Sbjct 314 GGEQAAVEVCNRAKVFTLGESLGGVESLIEHPGRMTHASAAGSALEVPADLVRLSVGIEN 373 Query 376 IADLLGDLEQALG 388 DLL DL+QALG Sbjct 374 ADDLLADLQQALG 386 >gi|291437596|ref|ZP_06576986.1| cystathionine gamma-synthase [Streptomyces ghanaensis ATCC 14672] gi|291340491|gb|EFE67447.1| cystathionine gamma-synthase [Streptomyces ghanaensis ATCC 14672] Length=385 Score = 503 bits (1294), Expect = 3e-140, Method: Compositional matrix adjust. Identities = 247/373 (67%), Positives = 292/373 (79%), Gaps = 0/373 (0%) Query 16 TRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVE 75 T AIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPTR ALE +LAA+E Sbjct 12 TLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALE 71 Query 76 EGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA 135 G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL KV RW V+++ + Sbjct 72 GGRRGLAFASGLAAEDCLLRTLLAPGDHVVIPNDAYGGTFRLFAKVVARWGVEWSVADTS 131 Query 136 DLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPL 195 D AV AA+TP+T+ +WVETP+NPLL I DI A+A++ D A+++VDNTFA+P LQQPL Sbjct 132 DPAAVRAALTPKTKAVWVETPSNPLLGITDIAAVAQVARDAGARLVVDNTFATPYLQQPL 191 Query 196 RLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGL 255 LGADVV+HS TKY+GGHSDVVGGAL+T D EL EE AF QN GAV GPFD++L +RG Sbjct 192 LLGADVVVHSLTKYMGGHSDVVGGALITADAELGEELAFHQNAMGAVAGPFDSWLVLRGT 251 Query 256 KTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMR 315 KTL +RM RHSENA VA+ L HP V+SVLYPGLP HPGHE+AA+QMR FGGMVS R++ Sbjct 252 KTLPVRMDRHSENATRVADMLTRHPRVTSVLYPGLPDHPGHEVAAKQMRAFGGMVSFRVK 311 Query 316 AGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIED 375 G AA ++C +T VF L ESLGGVESLIEHP MTHAS AGS LEVP DLVRLSVGIE+ Sbjct 312 GGEEAAVEVCNRTGVFTLGESLGGVESLIEHPGRMTHASAAGSALEVPGDLVRLSVGIEN 371 Query 376 IADLLGDLEQALG 388 + DLL DL+QALG Sbjct 372 VDDLLDDLQQALG 384 >gi|119715220|ref|YP_922185.1| cystathionine gamma-lyase [Nocardioides sp. JS614] gi|119535881|gb|ABL80498.1| cystathionine gamma-lyase [Nocardioides sp. JS614] Length=387 Score = 502 bits (1293), Expect = 3e-140, Method: Compositional matrix adjust. Identities = 252/382 (66%), Positives = 295/382 (78%), Gaps = 1/382 (0%) Query 8 HQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAAL 67 H+ SG TRAIHAGY PD ATGAV PIYA+STF QDGVGGLRGG+EY+R+ NPTR AL Sbjct 6 HRTKSGFETRAIHAGYEPDAATGAVIPPIYATSTFKQDGVGGLRGGYEYSRSANPTRTAL 65 Query 68 EASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDV 127 EA++AA+EEG AF+SG+AA D +RA+ RPGDHVVIPDDAYGGTFRL DKV W + Sbjct 66 EANIAALEEGERGFAFASGLAAEDTLVRALCRPGDHVVIPDDAYGGTFRLFDKVEQVWGL 125 Query 128 QYTPVRLADLDAVGAAITP-RTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTF 186 ++P ++D +AV AAI P TRL+WVETPTNPLL+I D+ A+A + D A ++VDNTF Sbjct 126 AHSPAPVSDAEAVAAAIRPGETRLVWVETPTNPLLNIGDLEALAAVAHDAGALLVVDNTF 185 Query 187 ASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPF 246 ASP LQQPL LGADVV+HSTTKY GGHSDVVGGALV D +L E F QN GAV GPF Sbjct 186 ASPYLQQPLTLGADVVVHSTTKYCGGHSDVVGGALVVKDLDLAERVGFHQNAMGAVAGPF 245 Query 247 DAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGF 306 DA+LT+RGLKTL LRM+RH +NA V +FL HP+V V+YPGL +HPGHE+A RQMR F Sbjct 246 DAWLTLRGLKTLALRMERHCDNAERVVDFLTSHPAVGDVIYPGLETHPGHEVAQRQMRRF 305 Query 307 GGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDL 366 GGMVS R+ G A +C +T +F L ESLGGVESLIEHP MTHAS AG+ LEVP DL Sbjct 306 GGMVSFRVHGGEEQALAVCDRTEIFTLGESLGGVESLIEHPGRMTHASVAGTDLEVPPDL 365 Query 367 VRLSVGIEDIADLLGDLEQALG 388 VRLSVGIE DL+ DLE+ALG Sbjct 366 VRLSVGIETADDLVADLERALG 387 >gi|29829847|ref|NP_824481.1| cystathionine gamma-synthase [Streptomyces avermitilis MA-4680] gi|29606956|dbj|BAC71016.1| putative cystathionine gamma-synthase [Streptomyces avermitilis MA-4680] Length=384 Score = 502 bits (1293), Expect = 3e-140, Method: Compositional matrix adjust. Identities = 246/373 (66%), Positives = 291/373 (79%), Gaps = 0/373 (0%) Query 16 TRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVE 75 T AIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPTR ALE +LAA+E Sbjct 12 TLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALE 71 Query 76 EGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA 135 G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL KV +RW V+++ + Sbjct 72 GGRRGLAFASGLAAEDCLLRTLLSPGDHVVIPNDAYGGTFRLFAKVVSRWGVEWSVADTS 131 Query 136 DLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPL 195 D +AV AAITP+T+ IWVETP+NPLL I DI AIA++ + AK++VDNTFA+P LQQPL Sbjct 132 DPEAVRAAITPKTKAIWVETPSNPLLGITDIPAIAQIAREAGAKLVVDNTFATPYLQQPL 191 Query 196 RLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGL 255 LGADVV+HS TKY+GGHSDVVGGALV +D+EL EE A+ QN GAV GPFD++L +RG Sbjct 192 ALGADVVVHSLTKYMGGHSDVVGGALVVSDQELGEELAYHQNAMGAVAGPFDSWLVLRGT 251 Query 256 KTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMR 315 KTL +RM RHSENA V E L H V+ VLYPGLP HPGHEIAA+QMR FGGMVS ++ Sbjct 252 KTLSVRMDRHSENATKVTEMLTRHARVTRVLYPGLPEHPGHEIAAKQMRAFGGMVSFQVE 311 Query 316 AGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIED 375 G AA ++C + +VF L ESLGGVESLIEHP MTHAS AGS LEVP DLVRLSVGIE+ Sbjct 312 GGEEAAVEVCNRAKVFTLGESLGGVESLIEHPGRMTHASAAGSALEVPADLVRLSVGIEN 371 Query 376 IADLLGDLEQALG 388 + DLL DL+QALG Sbjct 372 VDDLLQDLQQALG 384 >gi|320008890|gb|ADW03740.1| Cys/Met metabolism pyridoxal-phosphate-dependent protein [Streptomyces flavogriseus ATCC 33331] Length=381 Score = 502 bits (1293), Expect = 4e-140, Method: Compositional matrix adjust. Identities = 247/373 (67%), Positives = 288/373 (78%), Gaps = 0/373 (0%) Query 16 TRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVE 75 T AIHAG DP TGAV PIY ST+ QDGVGGLRGG+EY+R+ NPTR ALE +LAA+E Sbjct 9 TLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALE 68 Query 76 EGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA 135 G AF+SG+AA DC LR +L PGDHVVIP+DAYGGTFRL KV +RW V+++ + Sbjct 69 GGRRGLAFASGLAAEDCLLRTLLTPGDHVVIPNDAYGGTFRLFAKVASRWGVEFSVADTS 128 Query 136 DLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPL 195 D+ AV AA+TPRTR IWVETP+NPLL I DI A+A + A+++VDNTFASP LQQPL Sbjct 129 DVSAVRAALTPRTRAIWVETPSNPLLGITDIAAVAGVARQAGARLVVDNTFASPYLQQPL 188 Query 196 RLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGL 255 LGADVV+HSTTKY+GGHSDVVGGALV ND EL EE A+ QN GAV GPFDA+L +RG+ Sbjct 189 SLGADVVVHSTTKYMGGHSDVVGGALVVNDPELAEELAYHQNAMGAVAGPFDAWLVLRGI 248 Query 256 KTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMR 315 KTL +RM RH ENA VA+ L HP V+ VLYPGLP HPGHEIAA+QM+ FGGMVS R+ Sbjct 249 KTLAVRMDRHDENATKVADLLTRHPKVTQVLYPGLPEHPGHEIAAKQMKAFGGMVSFRVS 308 Query 316 AGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIED 375 G AA ++C + +F L ESLGGVESL+EHP MTHAS AGS LEVP DLVRLSVGIE+ Sbjct 309 GGEEAAVEVCNRAELFTLGESLGGVESLLEHPGRMTHASAAGSPLEVPADLVRLSVGIEN 368 Query 376 IADLLGDLEQALG 388 DLL DL QALG Sbjct 369 ADDLLADLTQALG 381 >gi|271969752|ref|YP_003343948.1| cystathionine gamma-lyase [Streptosporangium roseum DSM 43021] gi|270512927|gb|ACZ91205.1| Cystathionine gamma-lyase [Streptosporangium roseum DSM 43021] Length=379 Score = 502 bits (1292), Expect = 5e-140, Method: Compositional matrix adjust. Identities = 248/376 (66%), Positives = 290/376 (78%), Gaps = 0/376 (0%) Query 13 GPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLA 72 G T AIHAG PDP TGAV PIYA ST+ QDGVGGLR G+EY+R+ NPTR ALE ++A Sbjct 4 GFETLAIHAGQEPDPYTGAVVPPIYAVSTYKQDGVGGLRAGYEYSRSANPTRTALEEAMA 63 Query 73 AVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPV 132 AVE G AF+SG+AA D LR + +P DHV+IP+DAYGGT+RL KV +RW + Y P Sbjct 64 AVEGGTRGLAFASGLAAEDAVLRTVCKPDDHVIIPNDAYGGTYRLFSKVHSRWGLHYDPA 123 Query 133 RLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQ 192 L DL AV AA+T +TR++WVETPTNPLL IADI A+A+L D A ++VDNTFASP LQ Sbjct 124 PLGDLTAVAAAMTQKTRIVWVETPTNPLLGIADIAALAQLAHDNGALLVVDNTFASPYLQ 183 Query 193 QPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTM 252 QPL LGAD+V+HSTTKY+GGHSDVVGGALVT D +L E AF QN GAV GPFDA+LT+ Sbjct 184 QPLSLGADIVVHSTTKYVGGHSDVVGGALVTADADLGAELAFHQNAMGAVAGPFDAWLTL 243 Query 253 RGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSV 312 RGLKTL +RM RH +NA V + L HP V+SVLYPG+P HPGHE+AA+QMR FGGMVS Sbjct 244 RGLKTLGVRMDRHCDNAERVVDLLLAHPRVTSVLYPGMPDHPGHEVAAKQMRRFGGMVSF 303 Query 313 RMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVG 372 R+ G A ++C +T++F L ESLGGVESLIEHP MTHAS AGS LEVP DLVRLSVG Sbjct 304 RVAGGEAEAVEVCNRTKLFTLGESLGGVESLIEHPGRMTHASAAGSPLEVPGDLVRLSVG 363 Query 373 IEDIADLLGDLEQALG 388 IE I DLL DL QALG Sbjct 364 IESIDDLLADLSQALG 379 Lambda K H 0.319 0.135 0.393 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 758906400850 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40