BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv1168c

Length=346
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|15840611|ref|NP_335648.1|  PPE family protein [Mycobacterium t...   681    0.0  
gi|289744912|ref|ZP_06504290.1|  PPE family protein [Mycobacteriu...   678    0.0  
gi|294993357|ref|ZP_06799048.1|  PPE family protein [Mycobacteriu...   649    0.0  
gi|31792362|ref|NP_854855.1|  hypothetical protein Mb1201c [Mycob...   310    3e-82
gi|167970138|ref|ZP_02552415.1|  PPE family protein [Mycobacteriu...   310    3e-82
gi|240172421|ref|ZP_04751080.1|  PPE family protein [Mycobacteriu...   175    1e-41
gi|183980225|ref|YP_001848516.1|  PPE family protein, PPE51_2 [My...   147    3e-33
gi|183984212|ref|YP_001852503.1|  PPE family protein, PPE18 [Myco...   141    2e-31
gi|289747308|ref|ZP_06506686.1|  PPE [Mycobacterium tuberculosis ...   141    2e-31
gi|167967042|ref|ZP_02549319.1|  PPE family protein [Mycobacteriu...   139    5e-31
gi|118616708|ref|YP_905040.1|  PPE family protein [Mycobacterium ...   139    8e-31
gi|240169037|ref|ZP_04747696.1|  PPE family protein [Mycobacteriu...   138    1e-30
gi|183981478|ref|YP_001849769.1|  PPE family protein [Mycobacteri...   138    1e-30
gi|289449180|ref|ZP_06438924.1|  PPE family protein [Mycobacteriu...   138    1e-30
gi|148824686|ref|YP_001289440.1|  PPE family protein [Mycobacteri...   138    1e-30
gi|289445075|ref|ZP_06434819.1|  PPE family protein [Mycobacteriu...   137    2e-30
gi|31794652|ref|NP_857145.1|  PE family protein [Mycobacterium bo...   137    2e-30
gi|339633481|ref|YP_004725123.1|  PE family protein [Mycobacteriu...   137    2e-30
gi|254552580|ref|ZP_05143027.1|  PPE family protein [Mycobacteriu...   137    3e-30
gi|306809494|ref|ZP_07446162.1|  putative PPE family protein [Myc...   136    5e-30
gi|297636134|ref|ZP_06953914.1|  PPE family protein [Mycobacteriu...   136    6e-30
gi|296170357|ref|ZP_06851948.1|  PPE family protein [Mycobacteriu...   135    8e-30
gi|31792997|ref|NP_855490.1|  PPE family protein [Mycobacterium b...   132    1e-28
gi|57116921|ref|YP_177844.1|  PPE family protein [Mycobacterium t...   131    2e-28
gi|294996719|ref|ZP_06802410.1|  PPE family protein [Mycobacteriu...   130    3e-28
gi|289446957|ref|ZP_06436701.1|  PPE family protein [Mycobacteriu...   130    3e-28
gi|167967397|ref|ZP_02549674.1|  PPE family protein [Mycobacteriu...   130    5e-28
gi|308372058|ref|ZP_07427232.2|  putative PPE family protein [Myc...   129    5e-28
gi|289569375|ref|ZP_06449602.1|  PPE family protein [Mycobacteriu...   129    6e-28
gi|289554847|ref|ZP_06444057.1|  PPE family protein [Mycobacteriu...   129    6e-28
gi|294993380|ref|ZP_06799071.1|  PPE family protein [Mycobacteriu...   129    7e-28
gi|307084423|ref|ZP_07493536.1|  putative PPE family protein [Myc...   128    1e-27
gi|306784092|ref|ZP_07422414.1|  PPE family protein [Mycobacteriu...   128    1e-27
gi|340626377|ref|YP_004744829.1|  PPE family protein [Mycobacteri...   128    1e-27
gi|118617664|ref|YP_905996.1|  PPE family protein [Mycobacterium ...   128    2e-27
gi|240168614|ref|ZP_04747273.1|  PPE family protein, PPE51_2 [Myc...   128    2e-27
gi|183981860|ref|YP_001850151.1|  PPE family protein [Mycobacteri...   128    2e-27
gi|308231818|ref|ZP_07413879.2|  PPE family protein [Mycobacteriu...   127    2e-27
gi|254364253|ref|ZP_04980299.1|  PPE family protein [Mycobacteriu...   127    2e-27
gi|121637292|ref|YP_977515.1|  PPE family protein [Mycobacterium ...   127    2e-27
gi|253799589|ref|YP_003032590.1|  PPE family protein [Mycobacteri...   127    3e-27
gi|333990650|ref|YP_004523264.1|  PPE family protein [Mycobacteri...   127    3e-27
gi|297733134|ref|ZP_06962252.1|  PPE family protein [Mycobacteriu...   126    4e-27
gi|339294339|gb|AEJ46450.1|  PPE family protein [Mycobacterium tu...   125    8e-27
gi|289574028|ref|ZP_06454255.1|  PPE family protein [Mycobacteriu...   125    8e-27
gi|57116852|ref|YP_177801.1|  PPE family protein [Mycobacterium t...   125    1e-26
gi|240170866|ref|ZP_04749525.1|  PPE family protein [Mycobacteriu...   125    1e-26
gi|15841278|ref|NP_336315.1|  PPE family protein [Mycobacterium t...   124    2e-26
gi|254550816|ref|ZP_05141263.1|  PPE family protein [Mycobacteriu...   124    2e-26
gi|308376701|ref|ZP_07439733.2|  PPE family protein [Mycobacteriu...   123    4e-26


>gi|15840611|ref|NP_335648.1| PPE family protein [Mycobacterium tuberculosis CDC1551]
 gi|57116836|ref|YP_177791.1| PPE family protein [Mycobacterium tuberculosis H37Rv]
 gi|148660956|ref|YP_001282479.1| PPE family protein [Mycobacterium tuberculosis H37Ra]
 65 more sequence titles
 Length=346

 Score =  681 bits (1756),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 346/346 (100%), Positives = 346/346 (100%), Gaps = 0/346 (0%)

Query  1    MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST  60
            MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST
Sbjct  1    MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST  60

Query  61   IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT  120
            IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT
Sbjct  61   IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT  120

Query  121  NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLY  180
            NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLY
Sbjct  121  NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLY  180

Query  181  ELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ  240
            ELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ
Sbjct  181  ELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ  240

Query  241  MMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKA  300
            MMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKA
Sbjct  241  MMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKA  300

Query  301  VPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346
            VPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG
Sbjct  301  VPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346


>gi|289744912|ref|ZP_06504290.1| PPE family protein [Mycobacterium tuberculosis 02_1987]
 gi|289757264|ref|ZP_06516642.1| PPE family protein [Mycobacterium tuberculosis T85]
 gi|289685440|gb|EFD52928.1| PPE family protein [Mycobacterium tuberculosis 02_1987]
 gi|289712828|gb|EFD76840.1| PPE family protein [Mycobacterium tuberculosis T85]
 gi|326902792|gb|EGE49725.1| PPE family protein [Mycobacterium tuberculosis W-148]
 gi|339294159|gb|AEJ46270.1| PPE family protein [Mycobacterium tuberculosis CCDC5079]
 gi|339297800|gb|AEJ49910.1| PPE family protein [Mycobacterium tuberculosis CCDC5180]
Length=346

 Score =  678 bits (1750),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 345/346 (99%), Positives = 345/346 (99%), Gaps = 0/346 (0%)

Query  1    MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST  60
            MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST
Sbjct  1    MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST  60

Query  61   IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT  120
            IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT
Sbjct  61   IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT  120

Query  121  NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLY  180
            NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSP APIANPGALARLY
Sbjct  121  NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPLAPIANPGALARLY  180

Query  181  ELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ  240
            ELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ
Sbjct  181  ELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ  240

Query  241  MMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKA  300
            MMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKA
Sbjct  241  MMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKA  300

Query  301  VPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346
            VPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG
Sbjct  301  VPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346


>gi|294993357|ref|ZP_06799048.1| PPE family protein [Mycobacterium tuberculosis 210]
Length=349

 Score =  649 bits (1675),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 333/334 (99%), Positives = 333/334 (99%), Gaps = 0/334 (0%)

Query  13   LNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRAW  72
            LNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRAW
Sbjct  16   LNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRAW  75

Query  73   IVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFA  132
            IVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFA
Sbjct  76   IVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFA  135

Query  133  LDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLYELIGSVSETVGS  192
            LDALYAQYWSQDGEAMNLYATMAAAAARLTPFSP APIANPGALARLYELIGSVSETVGS
Sbjct  136  LDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPLAPIANPGALARLYELIGSVSETVGS  195

Query  193  FAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP  252
            FAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP
Sbjct  196  FAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP  255

Query  253  TLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGT  312
            TLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGT
Sbjct  256  TLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGT  315

Query  313  SWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346
            SWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG
Sbjct  316  SWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  349


>gi|31792362|ref|NP_854855.1| hypothetical protein Mb1201c [Mycobacterium bovis AF2122/97]
 gi|121637100|ref|YP_977323.1| PPE family protein [Mycobacterium bovis BCG str. Pasteur 1173P2]
 gi|167970139|ref|ZP_02552416.1| PPE Family protein [Mycobacterium tuberculosis H37Ra]
 gi|224989573|ref|YP_002644260.1| PPE Family protein [Mycobacterium bovis BCG str. Tokyo 172]
 gi|31617950|emb|CAD94062.1| PPE FAMILY PROTEIN [FIRST PART] [Mycobacterium bovis AF2122/97]
 gi|121492747|emb|CAL71218.1| PPE Family protein [first part] [Mycobacterium bovis BCG str. 
Pasteur 1173P2]
 gi|224772686|dbj|BAH25492.1| PPE Family protein [Mycobacterium bovis BCG str. Tokyo 172]
 gi|341601116|emb|CCC63789.1| PPE Family protein [first part] [Mycobacterium bovis BCG str. 
Moreau RDJ]
Length=180

 Score =  310 bits (793),  Expect = 3e-82, Method: Compositional matrix adjust.
 Identities = 169/174 (98%), Positives = 169/174 (98%), Gaps = 0/174 (0%)

Query  1    MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST  60
            MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST
Sbjct  1    MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSST  60

Query  61   IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT  120
            IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT
Sbjct  61   IMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATT  120

Query  121  NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPG  174
            NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPP     PG
Sbjct  121  NIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPGADRQPG  174


>gi|167970138|ref|ZP_02552415.1| PPE family protein [Mycobacterium tuberculosis H37Ra]
Length=161

 Score =  310 bits (793),  Expect = 3e-82, Method: Compositional matrix adjust.
 Identities = 160/161 (99%), Positives = 161/161 (100%), Gaps = 0/161 (0%)

Query  186  VSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNL  245
            +SETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNL
Sbjct  1    MSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNL  60

Query  246  AMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSA  305
            AMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSA
Sbjct  61   AMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSA  120

Query  306  PGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346
            PGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG
Sbjct  121  PGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  161


>gi|240172421|ref|ZP_04751080.1| PPE family protein [Mycobacterium kansasii ATCC 12478]
Length=384

 Score =  175 bits (443),  Expect = 1e-41, Method: Compositional matrix adjust.
 Identities = 146/389 (38%), Positives = 196/389 (51%), Gaps = 48/389 (12%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPS  58
            MD+ + PPE NS  +     A     AA AW  ++     AA  + + +  L  SWRGPS
Sbjct  1    MDYALLPPEVNSGRMWAGPGAGSLHAAAVAWDEMAANFYDAAGTYATMLANLAMSWRGPS  60

Query  59   STIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALA  118
            +T M AA   F AW+  +A+ AE    H  + A AYE AH   VPL  + TNRL    L 
Sbjct  61   ATKMTAAATHFVAWLTASAAEAERAGQHARLFAAAYEIAHLMTVPLAEVLTNRLVHHVLV  120

Query  119  TTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGAL--  176
             TN FG +TP I   +A Y + W+QD  AM  YA  +AAA+RLTPF+ PAP  +PG L  
Sbjct  121  ATNFFGQNTPLIMLNEADYGRMWAQDAAAMYAYAEASAAASRLTPFTAPAPTTDPGGLVG  180

Query  177  --------------------ARLYELIGSVSETVGSFAAPATKNLPSKLWTLLTKG----  212
                                ARL+EL  S    + + A+PA     SK+WT +T      
Sbjct  181  QFAARAVGTAHASGEVLQQVARLHELTPSA---LHALASPAGSGTWSKVWTAITDAASAM  237

Query  213  ----TYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPL----ELLP-N  263
                 + L   +++  P  + L+ ++G NMG MM  +A ++L     G       ++P  
Sbjct  238  RKTTEWGLLGGKVAFEPTIFSLSVMDGMNMGSMMQKIATKALAKAAMGGAAAATHMMPIT  297

Query  264  AVRPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVPTSAPGGP-SGTSWAQLGLAS  321
            A    VSA LG+AD+IG LSVPPSW V   +I P A  +P +    P SGT W Q+ ++S
Sbjct  298  APAHQVSAALGSADSIGRLSVPPSWAVKAPAILPDADLLPGAVAADPDSGTPWVQMAMSS  357

Query  322  LAGGAV----GAVAARTRSGVILRSPAAG  346
            LAG  V     A  ARTR   I R+PA G
Sbjct  358  LAGTGVARAGAAPMARTR--FIPRTPAGG  384


>gi|183980225|ref|YP_001848516.1| PPE family protein, PPE51_2 [Mycobacterium marinum M]
 gi|183173551|gb|ACC38661.1| PPE family protein, PPE51_2 [Mycobacterium marinum M]
Length=381

 Score =  147 bits (371),  Expect = 3e-33, Method: Compositional matrix adjust.
 Identities = 126/341 (37%), Positives = 168/341 (50%), Gaps = 37/341 (10%)

Query  1    MDFTIFPPEFNS-LNIQG-SARPFLVAANAWKNLSNELSYAASRFESEINGLITS-WRGP  57
            MDF + PPE NS L   G  A   L AAN+W  L+ EL   A  +ES ++GL +  W GP
Sbjct  1    MDFAMLPPEVNSGLMYTGPGAGSLLAAANSWDELAIELGTTAQTYESVLSGLTSMYWAGP  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            +S  MAA  AP+  W+ +TA   +  A      A A+E A+A  VP PVI  NR+  ++L
Sbjct  61   ASESMAAKAAPYVWWLHSTAEQTQQTATQCRAAAMAFEQAYAMTVPPPVILANRMQLMSL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALA  177
              TN FG +T AI AL+A YA+ W QD  AM  YAT AA AA+L PFS P    NP  L+
Sbjct  121  VATNFFGQNTAAIAALEAQYAEMWEQDAAAMYGYATSAAMAAQLVPFSSPQQTTNPAGLS  180

Query  178  R-----------------LYELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAAR  220
                              L +LI  V + + + A      LP     L   G +   A  
Sbjct  181  AQSAAVNQADATAAAANPLSDLIALVQKGLAALAGAFPNLLPDDFSIL--DGIFAGYATV  238

Query  221  ISSIPVEYVLAFVEG--SNMGQMMGNLAMR--SLTPTLKGPLELLPNA--VRPAVSA---  271
              S   E ++A + G  SN+G M+G  +     L P   G   +L +A  V  AVS    
Sbjct  239  GVSQDCESIIAGIIGAESNLG-MLGAASENPAELAPGDIGIGSVLSSAPSVGGAVSGPGA  297

Query  272  ---TLGNADTIGGLSVPPSWV--ADKSITPLAKAVPTSAPG  307
               ++G A +IG LSVP SW   A + +  L+ A  T+ PG
Sbjct  298  VLVSVGRAGSIGQLSVPASWAAPATRQVAALSSAGLTTIPG  338


>gi|183984212|ref|YP_001852503.1| PPE family protein, PPE18 [Mycobacterium marinum M]
 gi|183177538|gb|ACC42648.1| PPE family protein, PPE18 [Mycobacterium marinum M]
Length=393

 Score =  141 bits (355),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 119/344 (35%), Positives = 170/344 (50%), Gaps = 41/344 (11%)

Query  1    MDFTIFPPEFNSLNIQGSARP--FLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            MDF   PPE NS  +   A     LVAA AW +++ +L  AAS  +S I GL    W G 
Sbjct  1    MDFGSLPPEINSAKMYAGAGSGSILVAAEAWDSVAVDLYSAASSCQSVIWGLAFGQWVGA  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            S+++M AA AP+ AW+  TA+ AEL A+     A AYE+A AA VP  +I  NRL  + L
Sbjct  61   SASLMGAAAAPYVAWLGATATRAELAANQARGAAVAYESAFAATVPPALILENRLQLVTL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAAR-LTPFSPPAPIANPGAL  176
              TNIFG +TPAI   +A Y + W+QD  AM  YA  AA  A  LTPF     +AN G L
Sbjct  121  IATNIFGQNTPAIATTEAEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL  180

Query  177  -------------ARLYELIGSVSETVGSFAAPA-----TKNLPSKLWTLLTKGTYPLTA  218
                         A   +L+ +V + +   AAPA     T   P  L   +T        
Sbjct  181  VNQTAAVGQAIDSAAAGQLMSNVPQALQQLAAPAPQGASTATAPKSLLQSVTSSFSLSNL  240

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLEL-LPNAVRPAVSAT-----  272
            + I  +   ++     G+++ + MG+ +++   P+     E  + +A R AVS       
Sbjct  241  STIVGMENTHLSMANSGASIFKTMGD-SVKGFIPSASKAAETAVEHAARNAVSMVGGGGP  299

Query  273  -----------LGNADTIGGLSVPPSWV-ADKSITPLAKAVPTS  304
                       +G A ++GGL VP +W  A++S+ P A+A+P S
Sbjct  300  AGIGGWAPQGGVGQALSVGGLKVPQAWAEANQSVVPAARALPIS  343


>gi|289747308|ref|ZP_06506686.1| PPE [Mycobacterium tuberculosis 02_1987]
 gi|294995751|ref|ZP_06801442.1| PPE family protein [Mycobacterium tuberculosis 210]
 gi|289687836|gb|EFD55324.1| PPE [Mycobacterium tuberculosis 02_1987]
 gi|326905321|gb|EGE52254.1| PPE family protein [Mycobacterium tuberculosis W-148]
 gi|339296295|gb|AEJ48406.1| PPE family protein [Mycobacterium tuberculosis CCDC5079]
 gi|339299898|gb|AEJ52008.1| PPE family protein [Mycobacterium tuberculosis CCDC5180]
Length=393

 Score =  141 bits (355),  Expect = 2e-31, Method: Compositional matrix adjust.
 Identities = 138/398 (35%), Positives = 196/398 (50%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYGLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  ILR+PAAG
Sbjct  358  LGG--LPLGHSVNAGSGINNALRVPARAYAILRTPAAG  393


>gi|167967042|ref|ZP_02549319.1| PPE family protein [Mycobacterium tuberculosis H37Ra]
 gi|254366827|ref|ZP_04982868.1| PPE family protein [Mycobacterium tuberculosis str. Haarlem]
 gi|289555745|ref|ZP_06444955.1| PPE family protein [Mycobacterium tuberculosis KZN 605]
 gi|298526959|ref|ZP_07014368.1| PPE family protein [Mycobacterium tuberculosis 94_M4241A]
 gi|134152336|gb|EBA44381.1| PPE family protein [Mycobacterium tuberculosis str. Haarlem]
 gi|289440377|gb|EFD22870.1| PPE family protein [Mycobacterium tuberculosis KZN 605]
 gi|298496753|gb|EFI32047.1| PPE family protein [Mycobacterium tuberculosis 94_M4241A]
Length=392

 Score =  139 bits (351),  Expect = 5e-31, Method: Compositional matrix adjust.
 Identities = 138/398 (35%), Positives = 195/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            MDF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  1    MDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  59

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  60   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  119

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  120  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  179

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  180  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  238

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  239  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  296

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  297  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  356

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  357  LGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  392


>gi|118616708|ref|YP_905040.1| PPE family protein [Mycobacterium ulcerans Agy99]
 gi|118568818|gb|ABL03569.1| PPE family protein [Mycobacterium ulcerans Agy99]
Length=393

 Score =  139 bits (349),  Expect = 8e-31, Method: Compositional matrix adjust.
 Identities = 117/344 (35%), Positives = 170/344 (50%), Gaps = 41/344 (11%)

Query  1    MDFTIFPPEFNSLNIQGSARP--FLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            MDF   PPEFNS  +   A     LVAA AW +++ +L  AAS  +S I GL    W G 
Sbjct  1    MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVDLYSAASSCQSVIWGLAFGQWVGA  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            S+++M AA AP+ AW+  TA+ AEL A+     A AYE+A AA VP  +I  NRL  + L
Sbjct  61   SASLMGAAAAPYVAWLGATATQAELAANQARGAAVAYESAFAATVPPALILENRLQLVTL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAAR-LTPFSPPAPIANPGAL  176
              TNIFG +TPAI   +A Y + W+QD  AM  YA  AA  A  LTPF     +AN G L
Sbjct  121  IATNIFGQNTPAIATTEAEYGEMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGGL  180

Query  177  ARLY-------------ELIGSVSETVGSFAAPA-----TKNLPSKLWTLLTKGTYPLTA  218
             +               +L+ +V + +   AA A     T   P  L   +T        
Sbjct  181  VKQTAAVGQAIDSAAAGQLMSNVPQALQQLAATAPQGASTATAPKSLLQSVTSSFSSSNL  240

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLEL-LPNAVRPAVS-------  270
            + I  +   ++     G+++ + MG+ +++   P+     E  + +A R AVS       
Sbjct  241  STIVGMENTHLSMANSGASILKTMGD-SVKGFIPSASKAAETAVEHAARNAVSMVGGGGP  299

Query  271  ---------ATLGNADTIGGLSVPPSWV-ADKSITPLAKAVPTS  304
                       +G A ++GGL VP +W  A++++ P A+A+P S
Sbjct  300  AGIGGWAPQGGVGQALSVGGLKVPQAWAEANQAVVPAARALPIS  343


>gi|240169037|ref|ZP_04747696.1| PPE family protein [Mycobacterium kansasii ATCC 12478]
Length=391

 Score =  138 bits (348),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 134/395 (34%), Positives = 187/395 (48%), Gaps = 53/395 (13%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLITS-WRG  56
            MDF   PPE NS  +    GS    L AA  W  ++ +L  AAS  +S I GL+   WRG
Sbjct  1    MDFGALPPEINSARMYTGPGSGS-LLAAAQVWDGVAIDLYNAASAVQSVIWGLLVGPWRG  59

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+  W+ TTA+ AEL AD +   A AYEAA A  VP  VI  NR+  L 
Sbjct  60   TSAGLMVAAASPYVTWLGTTAAQAELTADQVRTAATAYEAAFATTVPPAVIAGNRIQLLT  119

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAAR-LTPFSPPAPIANPGA  175
            L  +N+FG +TPAI   +A Y + W+QD  AM  YA  AA AA  LTPF     I N G 
Sbjct  120  LIASNLFGQNTPAIAVTEADYGEMWAQDAAAMYGYAGSAAVAAETLTPFDESPEITNAGG  179

Query  176  LARL-------------YELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L +               +LI +V + +   A P     P     +LW  ++    P++ 
Sbjct  180  LVQQAGAVEEATDTAAANQLISTVPQALQQLAEPGQGTTPFTAVGELWKAISPHLSPIS-  238

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLE-LLPNAVR-----------  266
              I S+   +V     G +M     +L ++ + P     +E  + +  R           
Sbjct  239  -NIVSMLNNHVSMLSSGMSMTNTASSL-LKGMAPAAAQAVESAVESGARAMGSLGSGLGT  296

Query  267  -----PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP-----TSAPGGPS----G  311
                   V+A LG A +IG LSVP  W  A++++ P A+A+P     T+A  GP+    G
Sbjct  297  SGIGGSGVAAGLGRALSIGSLSVPHGWAAANQTVVPAARALPLAGVATAAETGPAPMLGG  356

Query  312  TSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG  346
                QL  A    G  G +    R  V+ R+PAAG
Sbjct  357  LPLGQLANAGGGNGVSGVLRVTPRPYVMPRTPAAG  391


>gi|183981478|ref|YP_001849769.1| PPE family protein [Mycobacterium marinum M]
 gi|183174804|gb|ACC39914.1| PPE family protein [Mycobacterium marinum M]
Length=427

 Score =  138 bits (348),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 135/388 (35%), Positives = 180/388 (47%), Gaps = 61/388 (15%)

Query  1    MDFTIFPPEFNS--LNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRGP  57
            MDF   PPE NS  + +   + P L AA  W  L+ EL   A+ + S ++GL   SWRGP
Sbjct  1    MDFGALPPEINSGRMYVGPGSGPMLAAAVVWDELAAELYATAAGYRSTLDGLTGGSWRGP  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            +S  MAAA AP+ AW+  TA+ AEL      V A AYE A AA VP PVI  NR   + L
Sbjct  61   ASASMAAAAAPYVAWMTATAAQAELAGSQAKVAASAYETAFAATVPPPVIAANRALLMGL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANP-GAL  176
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A ++TPF+ P  I +P GA+
Sbjct  121  VFTNIFGQNTPAIAATEAHYAEMWAQDAAAMYAYAGSSATATQVTPFTEPPQITSPSGAV  180

Query  177  -------------------ARLYELIGSVSETVGSFA-----APATKNLPS---------  203
                               A+L  LI  V   +   A     A A   LP          
Sbjct  181  SQAAAVTEAATASASSDITAQLSPLIAVVPNALQGMATSGNPAAAIAGLPDVALPAGIIT  240

Query  204  ---KLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-MMGNLAMRS-LTPTLKG--  256
                  T+L     P T   ++ +P    LAF +     Q M+G  A  S   P + G  
Sbjct  241  DLQNFTTILDTLDGPFTIQGLTGVPGGPFLAFGQVYAFSQNMVGAQAFFSPAEPVIGGLA  300

Query  257  PLELLPN----------AVRPAVSATLGNADTIGGLSVPPSWVADK-SITPLAKAVPTSA  305
            PL    N          +V    S  +G+A  +G +SVP  W  +  +I      +PTS 
Sbjct  301  PLAGEANLGAAGVVGGPSVGGQASGAMGHAALVGNMSVPQGWTQEAPAIRVFVSELPTSV  360

Query  306  PGGPSGT------SWAQLGLASLAGGAV  327
               P+ T       + Q+ L+SLAG A+
Sbjct  361  TAAPAATLAGESAVFNQMALSSLAGRAL  388


>gi|289449180|ref|ZP_06438924.1| PPE family protein [Mycobacterium tuberculosis CPHL_A]
 gi|340628446|ref|YP_004746898.1| PE family protein [Mycobacterium canettii CIPT 140010059]
 gi|289422138|gb|EFD19339.1| PPE family protein [Mycobacterium tuberculosis CPHL_A]
 gi|340006636|emb|CCC45823.1| PE family protein [Mycobacterium canettii CIPT 140010059]
Length=393

 Score =  138 bits (348),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 138/398 (35%), Positives = 195/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  358  LGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  393


>gi|148824686|ref|YP_001289440.1| PPE family protein [Mycobacterium tuberculosis F11]
 gi|148723213|gb|ABR07838.1| PPE family protein [Mycobacterium tuberculosis F11]
Length=392

 Score =  138 bits (347),  Expect = 1e-30, Method: Compositional matrix adjust.
 Identities = 137/398 (35%), Positives = 194/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            MDF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  1    MDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  59

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  60   SSAGLMVAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  119

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  120  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  179

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  180  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  238

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  239  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  296

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  297  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  356

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  357  LGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  392


>gi|289445075|ref|ZP_06434819.1| PPE family protein [Mycobacterium tuberculosis T46]
 gi|289571709|ref|ZP_06451936.1| PPE family protein [Mycobacterium tuberculosis T17]
 gi|289755609|ref|ZP_06514987.1| PPE family protein [Mycobacterium tuberculosis EAS054]
 gi|289417994|gb|EFD15234.1| PPE family protein [Mycobacterium tuberculosis T46]
 gi|289545463|gb|EFD49111.1| PPE family protein [Mycobacterium tuberculosis T17]
 gi|289696196|gb|EFD63625.1| PPE family protein [Mycobacterium tuberculosis EAS054]
Length=390

 Score =  137 bits (346),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 143/406 (36%), Positives = 196/406 (49%), Gaps = 77/406 (18%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELL-------------PNAV  265
              +SSI           +N   MMG     S+T TL   L+ L              N V
Sbjct  240  -NVSSI----------ANNHMSMMGTGV--SMTNTLHSMLKGLAPAAAAQAVQTAAQNGV  286

Query  266  R---------------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP-------  302
            +                 V+A LG A ++G LSVPP+W  A++++TP A+A+P       
Sbjct  287  QAMSSLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSA  346

Query  303  -TSAPGGPSGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
              +APG   G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  347  AQTAPGHMLGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  390


>gi|31794652|ref|NP_857145.1| PE family protein [Mycobacterium bovis AF2122/97]
 gi|57117111|ref|YP_177976.1| PE family protein [Mycobacterium tuberculosis H37Rv]
 gi|121639396|ref|YP_979620.1| PE family protein [Mycobacterium bovis BCG str. Pasteur 1173P2]
 36 more sequence titles
 Length=393

 Score =  137 bits (346),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 137/398 (35%), Positives = 195/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  358  LGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  393


>gi|339633481|ref|YP_004725123.1| PE family protein [Mycobacterium africanum GM041182]
 gi|339332837|emb|CCC28560.1| PE family protein [Mycobacterium africanum GM041182]
Length=393

 Score =  137 bits (346),  Expect = 2e-30, Method: Compositional matrix adjust.
 Identities = 137/398 (35%), Positives = 195/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAARVRVAAAAYETAYRLTVPPPVIAENRTEVMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  358  LGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  393


>gi|254552580|ref|ZP_05143027.1| PPE family protein [Mycobacterium tuberculosis '98-R604 INH-RIF-EM']
Length=393

 Score =  137 bits (345),  Expect = 3e-30, Method: Compositional matrix adjust.
 Identities = 138/398 (35%), Positives = 195/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  310  SGTSWAQLGLASLAG-GAVGAVAARTRSGVILRSPAAG  346
             G     LG +  AG G   A+    R+  I R+PAAG
Sbjct  358  LGG--LPLGHSVNAGRGINNALRVPARAYAIPRTPAAG  393


>gi|306809494|ref|ZP_07446162.1| putative PPE family protein [Mycobacterium tuberculosis SUMu007]
 gi|308344226|gb|EFP33077.1| putative PPE family protein [Mycobacterium tuberculosis SUMu007]
Length=361

 Score =  136 bits (343),  Expect = 5e-30, Method: Compositional matrix adjust.
 Identities = 121/345 (36%), Positives = 173/345 (51%), Gaps = 47/345 (13%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP  302
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALP  342


>gi|297636134|ref|ZP_06953914.1| PPE family protein [Mycobacterium tuberculosis KZN 4207]
Length=393

 Score =  136 bits (342),  Expect = 6e-30, Method: Compositional matrix adjust.
 Identities = 136/398 (35%), Positives = 194/398 (49%), Gaps = 58/398 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLPSK----LWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A PA   +PS     LWT ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              +SSI   ++     G +M   + ++ ++ L P   +       N V            
Sbjct  240  -NVSSIANNHMSMMGTGVSMTNTLHSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGS  297

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP--------TSAPGGP  309
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P         +APG  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  310  SGTSWAQLGLASLAGGAV-GAVAARTRSGVILRSPAAG  346
             G     LG +  AG  +  A+    R+  I R+PAAG
Sbjct  358  LGG--LPLGHSVNAGSGINNALRVPARAYAIPRTPAAG  393


>gi|296170357|ref|ZP_06851948.1| PPE family protein [Mycobacterium parascrofulaceum ATCC BAA-614]
 gi|295895080|gb|EFG74799.1| PPE family protein [Mycobacterium parascrofulaceum ATCC BAA-614]
Length=459

 Score =  135 bits (341),  Expect = 8e-30, Method: Compositional matrix adjust.
 Identities = 131/333 (40%), Positives = 172/333 (52%), Gaps = 54/333 (16%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGP  57
            MD+ + PPE NS  +    GS    L AA AW  L+ EL   A+ + + I+GL T+W GP
Sbjct  1    MDYGVLPPEINSARMYAGPGSGS-MLTAAAAWDELATELRSIAASYSAVISGLTTAWLGP  59

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SST MAAA AP+ AW+  TA+ AE         A AYEAA AA VP PVIETNR    +L
Sbjct  60   SSTRMAAAAAPYAAWLNATAAQAEQSGSQARAAAAAYEAAFAATVPPPVIETNRAELESL  119

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANP----  173
              TN FG +T AI A +A YA+ W+QD  AM  YA  +AAAA +TPF PPA   NP    
Sbjct  120  IATNTFGQNTAAIAANEARYARMWAQDAAAMYGYAGQSAAAAAVTPFDPPAQNTNPAGTA  179

Query  174  GALARLYELIGSVSET----------------VGSFAAPATKNLP---------------  202
            G  A + +++G+ + T                + S AAPA  N P               
Sbjct  180  GQTAAVSQVVGTSAGTNSQAALSHLTSATPSALRSLAAPAAVNPPSASSLASFLSSLNSS  239

Query  203  --SKL---WTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNL--AMRSLTPTLK  255
              +KL     L+ K   P     IS+I     +  V G+   + +G+L  A+++ TP L 
Sbjct  240  PLAKLAGNVELIPKAVLPANDVLISTI-----MGLVIGA---RHLGDLTVAVKAATPGLA  291

Query  256  GPLELLPNAVRPAVSATLGNADTIGGLSVPPSW  288
              L     A+   VSAT+G A  +GGL+VPPSW
Sbjct  292  AGLGYAAPALGSTVSATVGQAGLVGGLAVPPSW  324


>gi|31792997|ref|NP_855490.1| PPE family protein [Mycobacterium bovis AF2122/97]
 gi|121637710|ref|YP_977933.1| PPE family protein [Mycobacterium bovis BCG str. Pasteur 1173P2]
 gi|224990194|ref|YP_002644881.1| PPE family protein [Mycobacterium bovis BCG str. Tokyo 172]
 29 more sequence titles
 Length=409

 Score =  132 bits (331),  Expect = 1e-28, Method: Compositional matrix adjust.
 Identities = 135/384 (36%), Positives = 181/384 (48%), Gaps = 53/384 (13%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            MDF   PPE NS  +     + P L AA AW  L+ EL  AA+ + S I GL +  W GP
Sbjct  1    MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAAVAP+ AWI  TA  AE       + AG YE A AA VP PVIE NR   ++L
Sbjct  61   SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA--  175
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A++L PFS P    NP A  
Sbjct  121  VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATA  180

Query  176  ------------------LARLYELIGSVSETVGSFAAPATKNLPSKLW--------TLL  209
                               A+L +LI  +  T+ S A  AT    S  W        T+L
Sbjct  181  AQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTIL  240

Query  210  TKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MMG-NLAMRSLTPT--LKGPLE  259
               T P +   + +IP  + L F +   + Q       ++G   A  +L+P   L+G   
Sbjct  241  ANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYI  300

Query  260  LLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPG---------GPS  310
                 +    +  +  A  +G LSVP  W       P+ +AV +  PG            
Sbjct  301  ADITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMRAVASVLPGTGAAPALAAEAP  357

Query  311  GTSWAQLGLASLAGGAVGAVAART  334
            G  + ++ L+SLAG A+   A R+
Sbjct  358  GALFGEMALSSLAGRALAGTAVRS  381


>gi|57116921|ref|YP_177844.1| PPE family protein [Mycobacterium tuberculosis H37Rv]
 gi|148661614|ref|YP_001283137.1| PPE family protein [Mycobacterium tuberculosis H37Ra]
 gi|148823021|ref|YP_001287775.1| PPE family protein [Mycobacterium tuberculosis F11]
 9 more sequence titles
 Length=409

 Score =  131 bits (330),  Expect = 2e-28, Method: Compositional matrix adjust.
 Identities = 135/384 (36%), Positives = 181/384 (48%), Gaps = 53/384 (13%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            MDF   PPE NS  +     + P L AA AW  L+ EL  AA+ + S I GL +  W GP
Sbjct  1    MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAAVAP+ AWI  TA  AE       + AG YE A AA VP PVIE NR   ++L
Sbjct  61   SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA--  175
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A++L PFS P    NP A  
Sbjct  121  VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATA  180

Query  176  ------------------LARLYELIGSVSETVGSFAAPATKNLPSKLW--------TLL  209
                               A+L +LI  +  T+ S A  AT    S  W        T+L
Sbjct  181  AQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTIL  240

Query  210  TKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MMG-NLAMRSLTPT--LKGPLE  259
               T P +   + +IP  + L F +   + Q       ++G   A  +L+P   L+G   
Sbjct  241  ANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYI  300

Query  260  LLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPG---------GPS  310
                 +    +  +  A  +G LSVP  W       P+ +AV +  PG            
Sbjct  301  GDITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMRAVASVLPGTGAAPALAAEAP  357

Query  311  GTSWAQLGLASLAGGAVGAVAART  334
            G  + ++ L+SLAG A+   A R+
Sbjct  358  GALFGEMALSSLAGRALAGTAVRS  381


>gi|294996719|ref|ZP_06802410.1| PPE family protein [Mycobacterium tuberculosis 210]
 gi|13377907|gb|AAK20893.1| Rv1808-like protein [Mycobacterium microti]
 gi|13377909|gb|AAK20894.1| Rv1808-like protein [Mycobacterium microti]
 gi|339294744|gb|AEJ46855.1| PPE family protein [Mycobacterium tuberculosis CCDC5079]
 gi|339298372|gb|AEJ50482.1| PPE family protein [Mycobacterium tuberculosis CCDC5180]
Length=410

 Score =  130 bits (328),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 134/384 (35%), Positives = 181/384 (48%), Gaps = 53/384 (13%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            +DF   PPE NS  +     + P L AA AW  L+ EL  AA+ + S I GL +  W GP
Sbjct  2    LDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP  61

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAAVAP+ AWI  TA  AE       + AG YE A AA VP PVIE NR   ++L
Sbjct  62   SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL  121

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA--  175
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A++L PFS P    NP A  
Sbjct  122  VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATA  181

Query  176  ------------------LARLYELIGSVSETVGSFAAPATKNLPSKLW--------TLL  209
                               A+L +LI  +  T+ S A  AT    S  W        T+L
Sbjct  182  AQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTIL  241

Query  210  TKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MMG-NLAMRSLTPT--LKGPLE  259
               T P +   + +IP  + L F +   + Q       ++G   A  +L+P   L+G   
Sbjct  242  ANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYI  301

Query  260  LLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPG---------GPS  310
                 +    +  +  A  +G LSVP  W       P+ +AV +  PG            
Sbjct  302  ADITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMRAVASVLPGTGAAPALAAEAP  358

Query  311  GTSWAQLGLASLAGGAVGAVAART  334
            G  + ++ L+SLAG A+   A R+
Sbjct  359  GALFGEMALSSLAGRALAGTAVRS  382


>gi|289446957|ref|ZP_06436701.1| PPE family protein [Mycobacterium tuberculosis CPHL_A]
 gi|289419915|gb|EFD17116.1| PPE family protein [Mycobacterium tuberculosis CPHL_A]
Length=396

 Score =  130 bits (327),  Expect = 3e-28, Method: Compositional matrix adjust.
 Identities = 138/399 (35%), Positives = 193/399 (49%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYRLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++ L P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGLAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|167967397|ref|ZP_02549674.1| PPE family protein [Mycobacterium tuberculosis H37Ra]
 gi|253799148|ref|YP_003032149.1| PPE family protein [Mycobacterium tuberculosis KZN 1435]
 gi|254231990|ref|ZP_04925317.1| PPE family protein [Mycobacterium tuberculosis C]
 24 more sequence titles
 Length=410

 Score =  130 bits (326),  Expect = 5e-28, Method: Compositional matrix adjust.
 Identities = 134/384 (35%), Positives = 181/384 (48%), Gaps = 53/384 (13%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            +DF   PPE NS  +     + P L AA AW  L+ EL  AA+ + S I GL +  W GP
Sbjct  2    LDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP  61

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAAVAP+ AWI  TA  AE       + AG YE A AA VP PVIE NR   ++L
Sbjct  62   SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL  121

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA--  175
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A++L PFS P    NP A  
Sbjct  122  VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATA  181

Query  176  ------------------LARLYELIGSVSETVGSFAAPATKNLPSKLW--------TLL  209
                               A+L +LI  +  T+ S A  AT    S  W        T+L
Sbjct  182  AQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTIL  241

Query  210  TKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MMG-NLAMRSLTPT--LKGPLE  259
               T P +   + +IP  + L F +   + Q       ++G   A  +L+P   L+G   
Sbjct  242  ANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYI  301

Query  260  LLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPG---------GPS  310
                 +    +  +  A  +G LSVP  W       P+ +AV +  PG            
Sbjct  302  GDITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMRAVASVLPGTGAAPALAAEAP  358

Query  311  GTSWAQLGLASLAGGAVGAVAART  334
            G  + ++ L+SLAG A+   A R+
Sbjct  359  GALFGEMALSSLAGRALAGTAVRS  382


>gi|308372058|ref|ZP_07427232.2| putative PPE family protein [Mycobacterium tuberculosis SUMu004]
 gi|308334577|gb|EFP23428.1| putative PPE family protein [Mycobacterium tuberculosis SUMu004]
Length=399

 Score =  129 bits (325),  Expect = 5e-28, Method: Compositional matrix adjust.
 Identities = 134/384 (35%), Positives = 181/384 (48%), Gaps = 53/384 (13%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            +DF   PPE NS  +     + P L AA AW  L+ EL  AA+ + S I GL +  W GP
Sbjct  2    LDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP  61

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAAVAP+ AWI  TA  AE       + AG YE A AA VP PVIE NR   ++L
Sbjct  62   SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL  121

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA--  175
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A++L PFS P    NP A  
Sbjct  122  VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATA  181

Query  176  ------------------LARLYELIGSVSETVGSFAAPATKNLPSKLW--------TLL  209
                               A+L +LI  +  T+ S A  AT    S  W        T+L
Sbjct  182  AQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTIL  241

Query  210  TKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MMG-NLAMRSLTPT--LKGPLE  259
               T P +   + +IP  + L F +   + Q       ++G   A  +L+P   L+G   
Sbjct  242  ANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYI  301

Query  260  LLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPG---------GPS  310
                 +    +  +  A  +G LSVP  W       P+ +AV +  PG            
Sbjct  302  GDITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMRAVASVLPGTGAAPALAAEAP  358

Query  311  GTSWAQLGLASLAGGAVGAVAART  334
            G  + ++ L+SLAG A+   A R+
Sbjct  359  GALFGEMALSSLAGRALAGTAVRS  382


>gi|289569375|ref|ZP_06449602.1| PPE family protein [Mycobacterium tuberculosis T17]
 gi|289543129|gb|EFD46777.1| PPE family protein [Mycobacterium tuberculosis T17]
Length=397

 Score =  129 bits (325),  Expect = 6e-28, Method: Compositional matrix adjust.
 Identities = 138/400 (35%), Positives = 192/400 (48%), Gaps = 58/400 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMT  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI A  A Y+Q W QD EAM  Y AT A A   L PF     I NPG 
Sbjct  121  LTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSL--TPTLKGPLELLPNAVR----------  266
              I S+   +V     G +M   + ++ ++ L      +       N V+          
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGLAPAAAAQAVQTAAQNGVQAMSSLGSQLG  297

Query  267  ---------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGT  312
                       V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G 
Sbjct  298  SSLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGH  357

Query  313  SWAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
                L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  MLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  397


>gi|289554847|ref|ZP_06444057.1| PPE family protein [Mycobacterium tuberculosis KZN 605]
 gi|289439479|gb|EFD21972.1| PPE family protein [Mycobacterium tuberculosis KZN 605]
Length=395

 Score =  129 bits (325),  Expect = 6e-28, Method: Compositional matrix adjust.
 Identities = 137/399 (35%), Positives = 190/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            MDF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  1    MDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  59

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  60   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  119

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  120  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  179

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  180  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  238

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N VR           
Sbjct  239  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVRAMSSLGSQLGS  296

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  297  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  356

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  357  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  395


>gi|294993380|ref|ZP_06799071.1| PPE family protein [Mycobacterium tuberculosis 210]
Length=390

 Score =  129 bits (324),  Expect = 7e-28, Method: Compositional matrix adjust.
 Identities = 129/385 (34%), Positives = 188/385 (49%), Gaps = 51/385 (13%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAQMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSSLGS  297

Query  267  ----PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVPTSAPGGPSGTSWAQLGLAS  321
                  V+A LG A ++G LSVP +W  A++++TP A+A+P +     S TS A+ G   
Sbjct  298  SGLGGGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLT-----SLTSAAERGPGQ  352

Query  322  LAGGA-VGAVAARTRSGV--ILRSP  343
            + GG  VG + AR   G+  +LR P
Sbjct  353  MLGGLPVGQMGARAGGGLSGVLRVP  377


>gi|307084423|ref|ZP_07493536.1| putative PPE family protein [Mycobacterium tuberculosis SUMu012]
 gi|308365983|gb|EFP54834.1| putative PPE family protein [Mycobacterium tuberculosis SUMu012]
Length=336

 Score =  128 bits (322),  Expect = 1e-27, Method: Compositional matrix adjust.
 Identities = 87/178 (49%), Positives = 105/178 (59%), Gaps = 3/178 (1%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGP  57
            +DF   PPE NS  +     + P L AA AW  L+ EL  AA+ + S I GL +  W GP
Sbjct  2    LDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP  61

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAAVAP+ AWI  TA  AE       + AG YE A AA VP PVIE NR   ++L
Sbjct  62   SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL  121

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA  175
              TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A A++L PFS P    NP A
Sbjct  122  VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSA  179


>gi|306784092|ref|ZP_07422414.1| PPE family protein [Mycobacterium tuberculosis SUMu003]
 gi|306788459|ref|ZP_07426781.1| PPE family protein [Mycobacterium tuberculosis SUMu004]
 gi|306792785|ref|ZP_07431087.1| PPE family protein [Mycobacterium tuberculosis SUMu005]
 gi|306797185|ref|ZP_07435487.1| PPE family protein [Mycobacterium tuberculosis SUMu006]
 gi|308331160|gb|EFP20011.1| PPE family protein [Mycobacterium tuberculosis SUMu003]
 gi|308334942|gb|EFP23793.1| PPE family protein [Mycobacterium tuberculosis SUMu004]
 gi|308338747|gb|EFP27598.1| PPE family protein [Mycobacterium tuberculosis SUMu005]
 gi|308342446|gb|EFP31297.1| PPE family protein [Mycobacterium tuberculosis SUMu006]
Length=396

 Score =  128 bits (322),  Expect = 1e-27, Method: Compositional matrix adjust.
 Identities = 136/399 (35%), Positives = 191/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|340626377|ref|YP_004744829.1| PPE family protein [Mycobacterium canettii CIPT 140010059]
 gi|340004567|emb|CCC43711.1| PPE family protein [Mycobacterium canettii CIPT 140010059]
Length=396

 Score =  128 bits (322),  Expect = 1e-27, Method: Compositional matrix adjust.
 Identities = 136/399 (35%), Positives = 191/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAQMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE AH   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAHGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|118617664|ref|YP_905996.1| PPE family protein [Mycobacterium ulcerans Agy99]
 gi|118569774|gb|ABL04525.1| PPE family protein [Mycobacterium ulcerans Agy99]
Length=388

 Score =  128 bits (321),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 128/390 (33%), Positives = 183/390 (47%), Gaps = 46/390 (11%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPS  58
            MD+   PPE NS  +     +     AA AW  L+ EL  AAS + S   GL   W+GP+
Sbjct  1    MDYAALPPEINSARMYAGPGSTSMQTAATAWDALATELYSAASCYSSITAGLAGKWQGPA  60

Query  59   STIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALA  118
            +T MA A AP+ AW+ TTA+ AEL +        A+  A AA VP PVI  NR    AL 
Sbjct  61   ATAMAQAAAPYAAWLSTTAAQAELASAQARAAVSAHAGAFAATVPPPVIAANRAHLAALI  120

Query  119  TTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALAR  178
             TN+ G ++PAI   +A Y Q W+QD  AM  YA   A+A RLTPF+ P PI +P  LAR
Sbjct  121  ATNLLGQNSPAIATTEANYEQMWAQDAAAMYGYAGACASATRLTPFTSPPPITDPVGLAR  180

Query  179  LYELIGSVSETVGSFAAPATK----------NLPSKLWTLLT------------KGTYPL  216
              + + +   T  S AAP+ +           LP  L  L+T              +  L
Sbjct  181  --QGVAATQSTGASAAAPSLEAVLAASQVITTLPGTLAGLVTAPIMTSLNSAFTSLSTSL  238

Query  217  TAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRP---------  267
            +     ++P+ + +  +   + G      A  SLT    G ++ + +  +          
Sbjct  239  SKLSSLAVPLNFAMYALNFLDKGIGFTKAATGSLTAAATGAVKAVESGAQSLGSVSLGIT  298

Query  268  ----AVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTS------APGGPSGTSWAQL  317
                A+SA +G   T+G LSVP SW+   + + +A  +P+S         G +G  +  L
Sbjct  299  GSGAALSAPMGRGMTVGALSVPHSWITAPATSAVAANLPSSFSSVGTLDSGTAGMPFMPL  358

Query  318  -GLASLAGGAVGAVAARTRSGVILRSPAAG  346
             G+A  +     A     RS V+ RSPAAG
Sbjct  359  TGMAGRSANGPAASRFELRSTVVPRSPAAG  388


>gi|240168614|ref|ZP_04747273.1| PPE family protein, PPE51_2 [Mycobacterium kansasii ATCC 12478]
Length=378

 Score =  128 bits (321),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 118/347 (35%), Positives = 174/347 (51%), Gaps = 52/347 (14%)

Query  1    MDFTIFPPEFNSLNIQGSARP--FLVAANAWKNLSNELSYAASRFESEINGLIT-SWRGP  57
            MDF + PPE NS  I     P   L AA +W  L+ EL   A  +ES ++GL T  W GP
Sbjct  1    MDFALLPPEVNSGRIYTGPGPGSLLAAAGSWDALATELDTTAQTYESVVSGLTTLDWYGP  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            +S  MAA VAP+ +W+ TTA+  +  A      A A++ A A  VP P I  NR+  +AL
Sbjct  61   ASESMAAKVAPYVSWLYTTATQTKQTAMQARAAAAAFDQAFAMTVPPPAIAANRIQLMAL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALA  177
              TN FG +T AI A +A YA+ W+QD  AM  YAT + AAA+L PF  P+   +P  L+
Sbjct  121  IATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATSSTAAAQLMPFPSPSQTTDPAGLS  180

Query  178  R-----------------LYELIGSVSETVGSFAAPATKN-LPSKLWTLLTKGTYPLTAA  219
                              + +L+ +VS+++G+ +     N LP+    L   G + + A 
Sbjct  181  AQSAAVAQANASAAATDPISQLVAAVSQSLGALSGLQIPNFLPADYAVL--DGIFAIYAT  238

Query  220  RISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLP-------NAVRP-----  267
              +   ++ V +  +G     ++G+ A  +L P L    E +P        A +P     
Sbjct  239  FSA---IDSVESIADG-----IIGDEA--ALVPALTSATEAMPAEASTLVAAQQPVGAGS  288

Query  268  -----AVSATLGNADTIGGLSVPPSWV--ADKSITPLAKAVPTSAPG  307
                 AV A+ G A +IG LSVP SW   A ++++ L+ A  T+ PG
Sbjct  289  GLGPNAVLASAGRAGSIGQLSVPASWAAPATRTVSALSPAGLTTIPG  335


>gi|183981860|ref|YP_001850151.1| PPE family protein [Mycobacterium marinum M]
 gi|183175186|gb|ACC40296.1| PPE family protein [Mycobacterium marinum M]
Length=388

 Score =  128 bits (321),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 126/388 (33%), Positives = 183/388 (48%), Gaps = 42/388 (10%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPS  58
            MD+   PPE NS  +     +     AA AW  L+ EL  AAS + S   GL   W+GP+
Sbjct  1    MDYAALPPEINSARMYSGPGSTSMQTAATAWDALATELYSAASCYSSITAGLAGKWQGPA  60

Query  59   STIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALA  118
            +T MA A AP+ AW+ TTA+ AEL +        A+  A AA VP PVI  NR    AL 
Sbjct  61   ATAMAQAAAPYAAWLSTTAAQAELASAQARAAVSAHAGAFAATVPPPVIAANRAHLAALI  120

Query  119  TTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALAR  178
             TN+ G ++PAI   +A Y Q W+QD  AM  YA   A+A RLTPF+ P PI +P  LAR
Sbjct  121  ATNLLGQNSPAIATTEANYEQMWAQDAAAMYGYAGACASATRLTPFTSPPPITDPVGLAR  180

Query  179  L----------------YELIGSVSETV----GSFAAPATKNLPSKLWTLLTKGTYPLTA  218
                              E + + S+ +    G+ A  AT  + + L +  T  +  L+ 
Sbjct  181  QGVAATQSTGASAAAPSLEAVLAASQVITTLPGTLAGLATAPIMTSLNSAFTSLSTSLSK  240

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRP-----------  267
                ++P+ + +  +   + G      A  SLT    G ++ + +  +            
Sbjct  241  LSSLAVPLNFAMYALNFLDKGIGFTKAATGSLTAAATGAVKAVESGAQSLGSVSLGITGS  300

Query  268  --AVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTS------APGGPSGTSWAQL-G  318
              A+SA +G   T+G LSVP SW+   + + +A  +P+S         G +G  +  L G
Sbjct  301  GAALSAAMGRGMTVGALSVPHSWITAPATSAVAANLPSSLSSVGTLDSGTAGMPFMPLTG  360

Query  319  LASLAGGAVGAVAARTRSGVILRSPAAG  346
            +A  +     A     RS V+ RSPAAG
Sbjct  361  MAGRSANGPAASRFELRSTVVPRSPAAG  388


>gi|308231818|ref|ZP_07413879.2| PPE family protein [Mycobacterium tuberculosis SUMu001]
 gi|308215968|gb|EFO75367.1| PPE family protein [Mycobacterium tuberculosis SUMu001]
Length=395

 Score =  127 bits (320),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 136/399 (35%), Positives = 190/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            MDF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  1    MDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  59

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  60   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  119

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  120  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  179

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  180  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  238

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  239  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  296

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  297  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  356

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  357  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  395


>gi|254364253|ref|ZP_04980299.1| PPE family protein [Mycobacterium tuberculosis str. Haarlem]
 gi|134149767|gb|EBA41812.1| PPE family protein [Mycobacterium tuberculosis str. Haarlem]
Length=395

 Score =  127 bits (320),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 137/399 (35%), Positives = 190/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            MDF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  1    MDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  59

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  60   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  119

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  120  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  179

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  180  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  238

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAV------------  265
              I S+   +V     G +M   + ++ ++ L P   +       N V            
Sbjct  239  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGLAPAAAQAVETAAQNGVWAMSSLGSQLGS  296

Query  266  -------RPAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  297  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  356

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  357  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  395


>gi|121637292|ref|YP_977515.1| PPE family protein [Mycobacterium bovis BCG str. Pasteur 1173P2]
 gi|224989766|ref|YP_002644453.1| PPE family protein [Mycobacterium bovis BCG str. Tokyo 172]
 gi|121492939|emb|CAL71410.1| PPE family protein [Mycobacterium bovis BCG str. Pasteur 1173P2]
 gi|224772879|dbj|BAH25685.1| PPE family protein [Mycobacterium bovis BCG str. Tokyo 172]
 gi|341601310|emb|CCC63983.1| PPE family protein [Mycobacterium bovis BCG str. Moreau RDJ]
Length=396

 Score =  127 bits (319),  Expect = 2e-27, Method: Compositional matrix adjust.
 Identities = 135/399 (34%), Positives = 191/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGL-ITSWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL + SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAQMWDSVASDLFSAASAFQSVVWGLTVGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVPP+W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|253799589|ref|YP_003032590.1| PPE family protein [Mycobacterium tuberculosis KZN 1435]
 gi|297730905|ref|ZP_06960023.1| PPE family protein [Mycobacterium tuberculosis KZN R506]
 gi|313658238|ref|ZP_07815118.1| PPE family protein [Mycobacterium tuberculosis KZN V2475]
 gi|253321092|gb|ACT25695.1| PPE family protein [Mycobacterium tuberculosis KZN 1435]
Length=396

 Score =  127 bits (319),  Expect = 3e-27, Method: Compositional matrix adjust.
 Identities = 136/399 (35%), Positives = 190/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N VR           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVRAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|333990650|ref|YP_004523264.1| PPE family protein [Mycobacterium sp. JDM601]
 gi|333486619|gb|AEF36011.1| PPE family protein [Mycobacterium sp. JDM601]
Length=386

 Score =  127 bits (318),  Expect = 3e-27, Method: Compositional matrix adjust.
 Identities = 83/196 (43%), Positives = 109/196 (56%), Gaps = 4/196 (2%)

Query  1    MDFTIFPPEFNSLNIQGSARP--FLVAANAWKNLSNELSYAASRFESEINGLIT-SWRGP  57
            MDF   PPE NS  I   A P   L AA AW+ L+ EL+ AA+ + S I GL T SW GP
Sbjct  1    MDFGALPPEINSARIYAGAGPGSLLAAATAWQELATELNSAAASYGSVIAGLTTGSWAGP  60

Query  58   SSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLAL  117
            SS  MAAA  P+  W+  T + A+  A  +S    AYE A AA VP P+I  NR  +  L
Sbjct  61   SSVAMAAAAGPYITWLNATGAQAQQAAAQVSAAVAAYETAFAATVPPPLITANRSLQATL  120

Query  118  ATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANP-GAL  176
              TNI G +T AI   +A Y + W+QD  AM  YA  +A A R++PF+ P    +P G +
Sbjct  121  TATNILGQNTAAIATTEADYLEMWAQDTAAMYGYAGASALATRVSPFTSPPQTTDPSGQI  180

Query  177  ARLYELIGSVSETVGS  192
             + Y +  S + T G+
Sbjct  181  TQSYSVAQSAAATTGT  196


>gi|297733134|ref|ZP_06962252.1| PPE family protein [Mycobacterium tuberculosis KZN R506]
 gi|313660465|ref|ZP_07817345.1| PPE family protein [Mycobacterium tuberculosis KZN V2475]
Length=378

 Score =  126 bits (317),  Expect = 4e-27, Method: Compositional matrix adjust.
 Identities = 127/374 (34%), Positives = 183/374 (49%), Gaps = 54/374 (14%)

Query  22   FLVAANAWKNLSNELSYAASRFESEINGL-ITSWRGPSSTIMAAAVAPFRAWIVTTASLA  80
             + AA  W +++++L  AAS F+S + GL + SW G S+ +MAAA +P+ AW+  TA  A
Sbjct  10   LVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQA  69

Query  81   ELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQY  140
            +L A  + V A AYE A+   VP PVI  NR   + L  TN+ G +TPAI A  A Y+Q 
Sbjct  70   QLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAAYSQM  129

Query  141  WSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGAL-------------ARLYELIGSV  186
            W QD EAM  Y AT A A   L PF     I NPG L             A   +L+ +V
Sbjct  130  WGQDAEAMYGYAATAATATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNV  189

Query  187  SETVGSFAAPATKNLPSK----LWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMM  242
             + +   A PA   +PS     LWT ++    PL+   +SSI   ++     G +M   +
Sbjct  190  PQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLS--NVSSIANNHMSMMGTGVSMTNTL  247

Query  243  GNLAMRSLTP-TLKGPLELLPNAV-------------------RPAVSATLGNADTIGGL  282
             ++ ++ L P   +       N V                      V+A LG A ++G L
Sbjct  248  HSM-LKGLAPAAAQAVETAAENGVWAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSL  306

Query  283  SVPPSW-VADKSITPLAKAVP--------TSAPGGPSGTSWAQLGLASLAGGAV-GAVAA  332
            SVPP+W  A++++TP A+A+P         +APG   G     LG +  AG  +  A+  
Sbjct  307  SVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHMLGG--LPLGHSVNAGSGINNALRV  364

Query  333  RTRSGVILRSPAAG  346
              R+  I R+PAAG
Sbjct  365  PARAYAIPRTPAAG  378


>gi|339294339|gb|AEJ46450.1| PPE family protein [Mycobacterium tuberculosis CCDC5079]
Length=396

 Score =  125 bits (315),  Expect = 8e-27, Method: Compositional matrix adjust.
 Identities = 135/399 (34%), Positives = 191/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +MAAA +P+ AW+  TA  A+L A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|289574028|ref|ZP_06454255.1| PPE family protein [Mycobacterium tuberculosis K85]
 gi|289753443|ref|ZP_06512821.1| PPE family protein [Mycobacterium tuberculosis EAS054]
 gi|339631430|ref|YP_004723072.1| PPE family protein [Mycobacterium africanum GM041182]
 gi|289538459|gb|EFD43037.1| PPE family protein [Mycobacterium tuberculosis K85]
 gi|289694030|gb|EFD61459.1| PPE family protein [Mycobacterium tuberculosis EAS054]
 gi|339330786|emb|CCC26457.1| PPE family protein [Mycobacterium africanum GM041182]
Length=396

 Score =  125 bits (315),  Expect = 8e-27, Method: Compositional matrix adjust.
 Identities = 135/399 (34%), Positives = 190/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAQMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|57116852|ref|YP_177801.1| PPE family protein [Mycobacterium tuberculosis H37Rv]
 gi|148661151|ref|YP_001282674.1| PPE family protein [Mycobacterium tuberculosis H37Ra]
 gi|148822583|ref|YP_001287337.1| PPE family protein [Mycobacterium tuberculosis F11]
 21 more sequence titles
 Length=396

 Score =  125 bits (314),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 135/399 (34%), Positives = 190/399 (48%), Gaps = 57/399 (14%)

Query  1    MDFTIFPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRG  56
            +DF   PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G
Sbjct  2    VDFGALPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIG  60

Query  57   PSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLA  116
             S+ +M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + 
Sbjct  61   SSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMI  120

Query  117  LATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGA  175
            L  TN+ G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG 
Sbjct  121  LIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGG  180

Query  176  L-------------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTA  218
            L             A   +L+ +V + +   A P     P    S+LW  ++    PL+ 
Sbjct  181  LLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS-  239

Query  219  ARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR-----------  266
              I S+   +V     G +M   + ++ ++   P   +       N V+           
Sbjct  240  -NIVSMLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGS  297

Query  267  --------PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTS  313
                      V+A LG A ++G LSVP +W  A++++TP A+A+P    TSA     G  
Sbjct  298  SLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHM  357

Query  314  WAQLGLASL--AGGAVGAV--AART--RSGVILRSPAAG  346
               L L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  358  LGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  396


>gi|240170866|ref|ZP_04749525.1| PPE family protein [Mycobacterium kansasii ATCC 12478]
Length=351

 Score =  125 bits (313),  Expect = 1e-26, Method: Compositional matrix adjust.
 Identities = 115/296 (39%), Positives = 139/296 (47%), Gaps = 35/296 (11%)

Query  1    MDFTIFPPEFNSLNIQGS--ARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPS  58
            MDF   PPE NS  +     A P L AA AW  L+ EL  AA    S I  L  +W+G +
Sbjct  1    MDFGSLPPEVNSGRMYCGLGAGPMLAAATAWDELAAELHSAADAHRSAIMALTATWQGCA  60

Query  59   STIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALA  118
            ST MA+A A   AW+  TA+ AEL A H      AYEAA AA VP PVI  NR     L 
Sbjct  61   STSMASAAAHHVAWLSATAAHAELTATHARAAVSAYEAAFAATVPPPVIAANRALLATLV  120

Query  119  TTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALAR  178
             TNI G + PAI A +A Y Q W+QD   M  YA  + AA R TPF+ P    N   LA 
Sbjct  121  ATNILGQNGPAIAATEARYGQMWAQDAATMYAYAASSDAATRHTPFAWPPRTTNTAGLA-  179

Query  179  LYELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISS--IPVEYVLAFVEGS  236
                  S + +VG  A   T+        ++      L    ISS  I V  +L FV G 
Sbjct  180  ------SHAASVGQAAGAETQQ-------IVHAAVVTLQTLNISSTVISVLSLLCFVPG-  225

Query  237  NMGQMMGNLAMRSLTPTLKGPLELLPN-------AVRPAVSATLGNADTIGGLSVP  285
                     A+R LT      + ++P         V   VSA LG A  +GGLSVP
Sbjct  226  ---------ALRDLTMPAGMTVGMVPTQGAADTVKVGGTVSAGLGQATRVGGLSVP  272


>gi|15841278|ref|NP_336315.1| PPE family protein [Mycobacterium tuberculosis CDC1551]
 gi|13881506|gb|AAK46129.1| PPE family protein [Mycobacterium tuberculosis CDC1551]
Length=386

 Score =  124 bits (311),  Expect = 2e-26, Method: Compositional matrix adjust.
 Identities = 118/344 (35%), Positives = 161/344 (47%), Gaps = 51/344 (14%)

Query  39   AASRFESEINGL-ITSWRGPSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAA  97
            AA+ + S I GL +  W GPSS  MAAAVAP+ AWI  TA  AE       + AG YE A
Sbjct  18   AAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETA  77

Query  98   HAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAA  157
             AA VP PVIE NR   ++L  TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A 
Sbjct  78   FAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSAT  137

Query  158  AARLTPFSPPAPIANPGA--------------------LARLYELIGSVSETVGSFAAPA  197
            A++L PFS P    NP A                     A+L +LI  +  T+ S A  A
Sbjct  138  ASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTA  197

Query  198  TKNLPSKLW--------TLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MM  242
            T    S  W        T+L   T P +   + +IP  + L F +   + Q       ++
Sbjct  198  TATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALL  257

Query  243  G-NLAMRSLTPT--LKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAK  299
            G   A  +L+P   L+G        +    +  +  A  +G LSVP  W       P+ +
Sbjct  258  GPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMR  314

Query  300  AVPTSAPG---------GPSGTSWAQLGLASLAGGAVGAVAART  334
            AV +  PG            G  + ++ L+SLAG A+   A R+
Sbjct  315  AVASVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRS  358


>gi|254550816|ref|ZP_05141263.1| PPE family protein [Mycobacterium tuberculosis '98-R604 INH-RIF-EM']
 gi|297634368|ref|ZP_06952148.1| PPE family protein [Mycobacterium tuberculosis KZN 4207]
 gi|297731355|ref|ZP_06960473.1| PPE family protein [Mycobacterium tuberculosis KZN R506]
 gi|313658689|ref|ZP_07815569.1| PPE family protein [Mycobacterium tuberculosis KZN V2475]
Length=395

 Score =  124 bits (311),  Expect = 2e-26, Method: Compositional matrix adjust.
 Identities = 118/344 (35%), Positives = 161/344 (47%), Gaps = 51/344 (14%)

Query  39   AASRFESEINGL-ITSWRGPSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAA  97
            AA+ + S I GL +  W GPSS  MAAAVAP+ AWI  TA  AE       + AG YE A
Sbjct  27   AAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETA  86

Query  98   HAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAA  157
             AA VP PVIE NR   ++L  TNIFG +TPAI A +A YA+ W+QD  AM  YA  +A 
Sbjct  87   FAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSAT  146

Query  158  AARLTPFSPPAPIANPGA--------------------LARLYELIGSVSETVGSFAAPA  197
            A++L PFS P    NP A                     A+L +LI  +  T+ S A  A
Sbjct  147  ASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTA  206

Query  198  TKNLPSKLW--------TLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-------MM  242
            T    S  W        T+L   T P +   + +IP  + L F +   + Q       ++
Sbjct  207  TATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALL  266

Query  243  G-NLAMRSLTPT--LKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAK  299
            G   A  +L+P   L+G        +    +  +  A  +G LSVP  W       P+ +
Sbjct  267  GPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGW---AEAAPVMR  323

Query  300  AVPTSAPG---------GPSGTSWAQLGLASLAGGAVGAVAART  334
            AV +  PG            G  + ++ L+SLAG A+   A R+
Sbjct  324  AVASVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRS  367


>gi|308376701|ref|ZP_07439733.2| PPE family protein [Mycobacterium tuberculosis SUMu008]
 gi|308350282|gb|EFP39133.1| PPE family protein [Mycobacterium tuberculosis SUMu008]
Length=405

 Score =  123 bits (309),  Expect = 4e-26, Method: Compositional matrix adjust.
 Identities = 134/394 (35%), Positives = 188/394 (48%), Gaps = 57/394 (14%)

Query  6    FPPEFNSLNIQ---GSARPFLVAANAWKNLSNELSYAASRFESEINGLIT-SWRGPSSTI  61
             PPE NS  +    GSA   + AA  W +++++L  AAS F+S + GL T SW G S+ +
Sbjct  16   LPPEINSARMYAGPGSAS-LVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIGSSAGL  74

Query  62   MAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTN  121
            M AA +P+ AW+  TA  AEL A  + V A AYE A+   VP PVI  NR   + L  TN
Sbjct  75   MVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATN  134

Query  122  IFGIHTPAIFALDALYAQYWSQDGEAMNLY-ATMAAAAARLTPFSPPAPIANPGAL----  176
            + G +TPAI   +A Y + W+QD  AM  Y AT A A   L PF     I NPG L    
Sbjct  135  LLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGGLLEQA  194

Query  177  ---------ARLYELIGSVSETVGSFAAPATKNLP----SKLWTLLTKGTYPLTAARISS  223
                     A   +L+ +V + +   A P     P    S+LW  ++    PL+   I S
Sbjct  195  VAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLS--NIVS  252

Query  224  IPVEYVLAFVEGSNMGQMMGNLAMRSLTP-TLKGPLELLPNAVR----------------  266
            +   +V     G +M   + ++ ++   P   +       N V+                
Sbjct  253  MLNNHVSMTNSGVSMASTLHSM-LKGFAPAAAQAVETAAQNGVQAMSSLGSQLGSSLGSS  311

Query  267  ---PAVSATLGNADTIGGLSVPPSW-VADKSITPLAKAVP----TSAPGGPSGTSWAQLG  318
                 V+A LG A ++G LSVPP+W  A++++TP A+A+P    TSA     G     L 
Sbjct  312  GLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHMLGGLP  371

Query  319  LASL--AGGAVGAV--AART--RSGVILRSPAAG  346
            L  L  +GG  G V  A R   R+ V+ R PAAG
Sbjct  372  LGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG  405



Lambda     K      H
   0.316    0.129    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 636071322808


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40