BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1264 Length=397 Score E Sequences producing significant alignments: (Bits) Value gi|298524767|ref|ZP_07012176.1| adenylyl cyclase [Mycobacterium ... 780 0.0 gi|67463876|pdb|1Y10|A Chain A, Mycobacterial Adenylyl Cyclase R... 780 0.0 gi|15608404|ref|NP_215780.1| adenylyl cyclase [Mycobacterium tub... 779 0.0 gi|340626277|ref|YP_004744729.1| adenylyl cyclase [Mycobacterium... 777 0.0 gi|31792456|ref|NP_854949.1| adenylyl cyclase [Mycobacterium bov... 776 0.0 gi|308370675|ref|ZP_07422306.2| adenylyl cyclase [Mycobacterium ... 770 0.0 gi|289757362|ref|ZP_06516740.1| adenylyl cyclase [Mycobacterium ... 684 0.0 gi|240172636|ref|ZP_04751295.1| adenylate cyclase [Mycobacterium... 615 5e-174 gi|118619583|ref|YP_907915.1| adenylate cyclase [Mycobacterium u... 606 2e-171 gi|183984144|ref|YP_001852435.1| adenylate cyclase [Mycobacteriu... 604 7e-171 gi|289749807|ref|ZP_06509185.1| adenylyl cyclase [Mycobacterium ... 604 9e-171 gi|296170173|ref|ZP_06851768.1| adenylyl cyclase [Mycobacterium ... 587 8e-166 gi|254820138|ref|ZP_05225139.1| chain A, Myco adenylyl cyclase, ... 576 2e-162 gi|336458608|gb|EGO37575.1| family 3 adenylate cyclase [Mycobact... 575 4e-162 gi|254774293|ref|ZP_05215809.1| chain A, Myco adenylyl cyclase, ... 573 3e-161 gi|342862143|ref|ZP_08718786.1| chain A, Myco adenylyl cyclase, ... 572 3e-161 gi|41408605|ref|NP_961441.1| hypothetical protein MAP2507c [Myco... 572 4e-161 gi|333989874|ref|YP_004522488.1| adenylate cyclase CyaA [Mycobac... 474 1e-131 gi|126436538|ref|YP_001072229.1| putative adenylate/guanylate cy... 441 1e-121 gi|108800913|ref|YP_641110.1| adenylate/guanylate cyclase [Mycob... 439 4e-121 gi|120405404|ref|YP_955233.1| putative adenylate/guanylate cycla... 439 4e-121 gi|289573924|ref|ZP_06454151.1| LOW QUALITY PROTEIN: adenylyl cy... 435 8e-120 gi|315443297|ref|YP_004076176.1| family 3 adenylate cyclase [Myc... 434 1e-119 gi|145222831|ref|YP_001133509.1| putative adenylate/guanylate cy... 432 3e-119 gi|118467881|ref|YP_889269.1| adenylate and guanylate cyclase ca... 432 4e-119 gi|119389357|pdb|2EV1|A Chain A, Structure Of Rv1264n, The Regul... 407 2e-111 gi|240170700|ref|ZP_04749359.1| adenylyl cyclase (ATP pyrophosph... 382 7e-104 gi|183980191|ref|YP_001848482.1| adenylate cyclase, CyaA [Mycoba... 347 2e-93 gi|118619965|ref|YP_908297.1| adenylate cyclase, CyaA [Mycobacte... 345 6e-93 gi|284046120|ref|YP_003396460.1| adenylate/guanylate cyclase [Co... 243 3e-62 gi|111018939|ref|YP_701911.1| adenylate cyclase [Rhodococcus jos... 172 6e-41 gi|226361039|ref|YP_002778817.1| adenylate cyclase [Rhodococcus ... 152 1e-34 gi|333922036|ref|YP_004495617.1| putative adenylate cyclase [Amy... 142 1e-31 gi|226349941|ref|YP_002777054.1| hypothetical protein ROP_pROB02... 135 2e-29 gi|111022051|ref|YP_705023.1| adenylate cyclase [Rhodococcus jos... 121 2e-25 gi|226364555|ref|YP_002782337.1| adenylate cyclase [Rhodococcus ... 118 2e-24 gi|134098563|ref|YP_001104224.1| adenylate cyclase [Saccharopoly... 116 8e-24 gi|291003220|ref|ZP_06561193.1| adenylate cyclase [Saccharopolys... 115 9e-24 gi|300783495|ref|YP_003763786.1| adenylate cyclase [Amycolatopsi... 112 9e-23 gi|302524847|ref|ZP_07277189.1| adenylate cyclase [Streptomyces ... 111 2e-22 gi|296395295|ref|YP_003660179.1| adenylate/guanylate cyclase [Se... 110 3e-22 gi|226308544|ref|YP_002768504.1| adenylate cyclase [Rhodococcus ... 110 4e-22 gi|257056835|ref|YP_003134667.1| family 3 adenylate cyclase [Sac... 110 4e-22 gi|229488641|ref|ZP_04382507.1| adenylate cyclase [Rhodococcus e... 109 7e-22 gi|326333791|ref|ZP_08200024.1| adenylate cyclase [Nocardioidace... 109 9e-22 gi|291453042|ref|ZP_06592432.1| adenylate cyclase [Streptomyces ... 108 1e-21 gi|119855124|ref|YP_935729.1| putative adenylate/guanylate cycla... 107 3e-21 gi|311743182|ref|ZP_07716990.1| adenylate cyclase [Aeromicrobium... 105 1e-20 gi|317509276|ref|ZP_07966897.1| adenylate and Guanylate cyclase ... 105 2e-20 gi|296268690|ref|YP_003651322.1| adenylate/guanylate cyclase [Th... 101 3e-19 >gi|298524767|ref|ZP_07012176.1| adenylyl cyclase [Mycobacterium tuberculosis 94_M4241A] gi|298494561|gb|EFI29855.1| adenylyl cyclase [Mycobacterium tuberculosis 94_M4241A] Length=398 Score = 780 bits (2015), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/397 (100%), Positives = 397/397 (100%), Gaps = 0/397 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV Sbjct 2 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 61 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 62 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 121 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 122 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 181 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH Sbjct 182 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 241 Query 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG Sbjct 242 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 301 Query 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR Sbjct 302 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 361 Query 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 362 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 398 >gi|67463876|pdb|1Y10|A Chain A, Mycobacterial Adenylyl Cyclase Rv1264, Holoenzyme, Inhibited State gi|67463877|pdb|1Y10|B Chain B, Mycobacterial Adenylyl Cyclase Rv1264, Holoenzyme, Inhibited State gi|67463878|pdb|1Y10|C Chain C, Mycobacterial Adenylyl Cyclase Rv1264, Holoenzyme, Inhibited State gi|67463879|pdb|1Y10|D Chain D, Mycobacterial Adenylyl Cyclase Rv1264, Holoenzyme, Inhibited State gi|67463880|pdb|1Y11|A Chain A, Mycobacterial Adenylyl Cyclase Rv1264, Holoenzyme, Active State Length=407 Score = 780 bits (2013), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/397 (99%), Positives = 397/397 (100%), Gaps = 0/397 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 +TDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV Sbjct 1 MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH Sbjct 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 Query 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG Sbjct 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 Query 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR Sbjct 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 Query 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 >gi|15608404|ref|NP_215780.1| adenylyl cyclase [Mycobacterium tuberculosis H37Rv] gi|15840710|ref|NP_335747.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|148661051|ref|YP_001282574.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] 46 more sequence titles Length=397 Score = 779 bits (2012), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/397 (99%), Positives = 397/397 (100%), Gaps = 0/397 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 +TDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV Sbjct 1 MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH Sbjct 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 Query 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG Sbjct 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 Query 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR Sbjct 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 Query 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 >gi|340626277|ref|YP_004744729.1| adenylyl cyclase [Mycobacterium canettii CIPT 140010059] gi|340004467|emb|CCC43610.1| adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase) [Mycobacterium canettii CIPT 140010059] Length=397 Score = 777 bits (2006), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/397 (99%), Positives = 396/397 (99%), Gaps = 0/397 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 +TDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQG+TPDEIRATNPPLLLATRHLV Sbjct 1 MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGVTPDEIRATNPPLLLATRHLV 60 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH Sbjct 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 Query 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG Sbjct 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 Query 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR Sbjct 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 Query 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 RLRGIRGDVRLFRVRRGATRTGSGG AQDDDLAGSSP Sbjct 361 RLRGIRGDVRLFRVRRGATRTGSGGVAQDDDLAGSSP 397 >gi|31792456|ref|NP_854949.1| adenylyl cyclase [Mycobacterium bovis AF2122/97] gi|121637192|ref|YP_977415.1| adenylyl cyclase [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224989667|ref|YP_002644354.1| adenylyl cyclase [Mycobacterium bovis BCG str. Tokyo 172] gi|31618045|emb|CAD94156.1| ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) [Mycobacterium bovis AF2122/97] gi|121492839|emb|CAL71310.1| Adenylyl cyclase [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224772780|dbj|BAH25586.1| adenylyl cyclase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601210|emb|CCC63883.1| Adenylyl cyclase [Mycobacterium bovis BCG str. Moreau RDJ] Length=397 Score = 776 bits (2005), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/397 (99%), Positives = 396/397 (99%), Gaps = 0/397 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 +TDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV Sbjct 1 MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 MIQDMLFMQLRHMMETEAVNAGE AAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH Sbjct 181 MIQDMLFMQLRHMMETEAVNAGECAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 Query 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG Sbjct 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 Query 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR Sbjct 301 VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR 360 Query 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 361 RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 >gi|308370675|ref|ZP_07422306.2| adenylyl cyclase [Mycobacterium tuberculosis SUMu003] gi|308371923|ref|ZP_07426670.2| adenylyl cyclase [Mycobacterium tuberculosis SUMu004] gi|308373093|ref|ZP_07430976.2| adenylyl cyclase [Mycobacterium tuberculosis SUMu005] 13 more sequence titles Length=393 Score = 770 bits (1989), Expect = 0.0, Method: Compositional matrix adjust. Identities = 392/393 (99%), Positives = 393/393 (100%), Gaps = 0/393 (0%) Query 5 VREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG 64 +READDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG Sbjct 1 MREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG 60 Query 65 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP 124 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP Sbjct 61 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP 120 Query 125 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD 184 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD Sbjct 121 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD 180 Query 185 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR 244 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR Sbjct 181 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR 240 Query 245 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG 304 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG Sbjct 241 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG 300 Query 305 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG 364 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG Sbjct 301 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG 360 Query 365 IRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 IRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 361 IRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 393 >gi|289757362|ref|ZP_06516740.1| adenylyl cyclase [Mycobacterium tuberculosis T85] gi|289712926|gb|EFD76938.1| adenylyl cyclase [Mycobacterium tuberculosis T85] Length=401 Score = 684 bits (1766), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/356 (99%), Positives = 350/356 (99%), Gaps = 0/356 (0%) Query 42 PDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAV 101 PDEIR LLL TRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAV Sbjct 46 PDEIRRQPARLLLGTRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAV 105 Query 102 VHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATEL 161 VHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATEL Sbjct 106 VHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATEL 165 Query 162 DIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFA 221 DIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFA Sbjct 166 DIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFA 225 Query 222 DLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTV 281 DLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTV Sbjct 226 DLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTV 285 Query 282 LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVRE 341 LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVRE Sbjct 286 LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVRE 345 Query 342 ALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 ALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 346 ALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 401 >gi|240172636|ref|ZP_04751295.1| adenylate cyclase [Mycobacterium kansasii ATCC 12478] Length=397 Score = 615 bits (1585), Expect = 5e-174, Method: Compositional matrix adjust. Identities = 314/375 (84%), Positives = 335/375 (90%), Gaps = 3/375 (0%) Query 3 DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGD 62 +HV E +I DLL L GTARAERA+L+ WLLEQGIT DEIR NPPLLLATR L+GD Sbjct 19 EHVPEPVGRDIADLLDGLDGTARAERAELIAWLLEQGITADEIRLANPPLLLATRRLIGD 78 Query 63 DGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGL 122 DGTYVSAREISE YG+DL LLQRVQRA+GLARVDDPDA VHMRADGEAAA AQRFVELGL Sbjct 79 DGTYVSAREISETYGIDLALLQRVQRAIGLARVDDPDAAVHMRADGEAAATAQRFVELGL 138 Query 123 NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMI 182 NPDQ+V+VVRVLAEGLSHAAE MRYTAL AIMRPG TE+ IA+ SQALVS+IVPLLGPMI Sbjct 139 NPDQIVMVVRVLAEGLSHAAEVMRYTALSAIMRPGVTEVQIAQASQALVSRIVPLLGPMI 198 Query 183 QDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLA 242 Q+MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFT+LGEVVSAEELGHLA Sbjct 199 QEMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTKLGEVVSAEELGHLA 258 Query 243 GRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVA 302 GRLA LARDLTAPPV FIKTIGDAVM VCPDP PLLDTVLKLVEVVDTD FPRLRAGVA Sbjct 259 GRLAELARDLTAPPVRFIKTIGDAVMFVCPDPVPLLDTVLKLVEVVDTDAAFPRLRAGVA 318 Query 303 SGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRL 362 SGMAVSRAGDWFGSPVN ASRVTGVARPG VLVADSV E++GD GF+WSFAG RRL Sbjct 319 SGMAVSRAGDWFGSPVNAASRVTGVARPGTVLVADSVWESVGDGA---GFEWSFAGTRRL 375 Query 363 RGIRGDVRLFRVRRG 377 +GI+ + +LFRVRRG Sbjct 376 KGIKNEAKLFRVRRG 390 >gi|118619583|ref|YP_907915.1| adenylate cyclase [Mycobacterium ulcerans Agy99] gi|118571693|gb|ABL06444.1| adenylate cyclase [Mycobacterium ulcerans Agy99] Length=393 Score = 606 bits (1562), Expect = 2e-171, Method: Compositional matrix adjust. Identities = 305/374 (82%), Positives = 331/374 (89%), Gaps = 0/374 (0%) Query 3 DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGD 62 D E N DDLL L G ARAERA+L++WL QGIT EIR TNPPLLLATRH++GD Sbjct 6 DRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGITAAEIRTTNPPLLLATRHVIGD 65 Query 63 DGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGL 122 DGTYVS+REISE YG+DL+LLQRVQRAVGLARVDDPDAVV+MRADGEAAA QRF+ELGL Sbjct 66 DGTYVSSREISETYGIDLDLLQRVQRAVGLARVDDPDAVVYMRADGEAAAYTQRFIELGL 125 Query 123 NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMI 182 NPDQ+VLVVRVLAEGLS AAE MRYTALEAIM PGATELDIAKGS+ALVSQI PLLGPMI Sbjct 126 NPDQIVLVVRVLAEGLSRAAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMI 185 Query 183 QDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLA 242 Q+MLFMQLRHMMETEAVNAGERAAGKPLPGAR+V+VAFADLVGFT+LGEVVSAEELG LA Sbjct 186 QEMLFMQLRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELGQLA 245 Query 243 GRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVA 302 GRLA LAR+LTAPPV FIKTIGDAVMLVCPDPAPLLDTVL LVEVVDTD+ FPRLRAGVA Sbjct 246 GRLADLARELTAPPVRFIKTIGDAVMLVCPDPAPLLDTVLNLVEVVDTDDAFPRLRAGVA 305 Query 303 SGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRL 362 G AVSRAGDWFGSPVN ASR+TGVARPG VL ADSV +A+ D GF+WSFAGPRRL Sbjct 306 CGRAVSRAGDWFGSPVNAASRITGVARPGTVLAADSVCDAIRDTAAGAGFEWSFAGPRRL 365 Query 363 RGIRGDVRLFRVRR 376 +GI+ + +LFRVRR Sbjct 366 KGIKNETKLFRVRR 379 >gi|183984144|ref|YP_001852435.1| adenylate cyclase [Mycobacterium marinum M] gi|183177470|gb|ACC42580.1| adenylate cyclase [Mycobacterium marinum M] Length=393 Score = 604 bits (1558), Expect = 7e-171, Method: Compositional matrix adjust. Identities = 304/374 (82%), Positives = 330/374 (89%), Gaps = 0/374 (0%) Query 3 DHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGD 62 D E N DDLL L G ARAERA+L++WL QGIT EIR TNPPLLLATRH++GD Sbjct 6 DRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGITAAEIRTTNPPLLLATRHVIGD 65 Query 63 DGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGL 122 DGTYVS+REISE YG+DL+LLQRVQRAVGLARVDDPDAVV+MRADGEAAA QRF+ELGL Sbjct 66 DGTYVSSREISETYGIDLDLLQRVQRAVGLARVDDPDAVVYMRADGEAAAYTQRFIELGL 125 Query 123 NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMI 182 NPDQ+VLVVRVLAEGLS AAE MRYTALEAIM PG TELDIAKGS+ALVSQI PLLGPMI Sbjct 126 NPDQIVLVVRVLAEGLSRAAEVMRYTALEAIMHPGVTELDIAKGSKALVSQIAPLLGPMI 185 Query 183 QDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLA 242 Q+MLFMQLRHMMETEAVNAGERAAGKPLPGAR+V+VAFADLVGFT+LGEVVSAEELG LA Sbjct 186 QEMLFMQLRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSAEELGQLA 245 Query 243 GRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVA 302 GRLA LAR+LTAPPV FIKTIGDAVMLVCPDPAPLLDTVL LVEVVDTD+ FPRLRAGVA Sbjct 246 GRLADLARELTAPPVRFIKTIGDAVMLVCPDPAPLLDTVLNLVEVVDTDDAFPRLRAGVA 305 Query 303 SGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRL 362 G AVSRAGDWFGSPVN ASR+TGVARPG VL ADSV +A+ D GF+WSFAGPRRL Sbjct 306 CGRAVSRAGDWFGSPVNAASRITGVARPGTVLAADSVCDAVRDTAAGAGFEWSFAGPRRL 365 Query 363 RGIRGDVRLFRVRR 376 +GI+ + +LFRVRR Sbjct 366 KGIKNETKLFRVRR 379 >gi|289749807|ref|ZP_06509185.1| adenylyl cyclase [Mycobacterium tuberculosis T92] gi|289690394|gb|EFD57823.1| adenylyl cyclase [Mycobacterium tuberculosis T92] Length=308 Score = 604 bits (1557), Expect = 9e-171, Method: Compositional matrix adjust. Identities = 306/306 (100%), Positives = 306/306 (100%), Gaps = 0/306 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV Sbjct 2 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 61 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 62 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 121 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 122 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 181 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 240 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH Sbjct 182 MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH 241 Query 241 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 300 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG Sbjct 242 LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG 301 Query 301 VASGMA 306 VASGMA Sbjct 302 VASGMA 307 >gi|296170173|ref|ZP_06851768.1| adenylyl cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295895165|gb|EFG74881.1| adenylyl cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=374 Score = 587 bits (1514), Expect = 8e-166, Method: Compositional matrix adjust. Identities = 295/364 (82%), Positives = 328/364 (91%), Gaps = 3/364 (0%) Query 14 DDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREIS 73 DDLL L G AR ERA+LVEWL+EQGI+PDEIRATNPPLLLATRHL+GDDGTYVSAREIS Sbjct 8 DDLLDGLEGRARTERAELVEWLIEQGISPDEIRATNPPLLLATRHLIGDDGTYVSAREIS 67 Query 74 ENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRV 133 E +G+DL+LLQRVQRA+GLARVDDPDA++HMRADGEAAA AQRFVELGL+P+QVVLVVRV Sbjct 68 ETHGIDLDLLQRVQRAIGLARVDDPDAIIHMRADGEAAAYAQRFVELGLDPEQVVLVVRV 127 Query 134 LAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHM 193 LAEGLS AAE MRYTAL AIMRPGATEL+IAK S+ALV +I P LGPMIQ MLFMQLRHM Sbjct 128 LAEGLSRAAEVMRYTALSAIMRPGATELEIAKASKALVGEIAPELGPMIQHMLFMQLRHM 187 Query 194 METEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLT 253 METEAVNA ERAAGKPLPGARQ+TVAFADLVGFT++GE VSAEELGHLA RLA LARD+T Sbjct 188 METEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSAEELGHLANRLAVLARDIT 247 Query 254 APPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDW 313 PPV FIKTIGDAVM VCP+P P+LD V+KLV+ VDTDN+FPRLRAGVASGMAVSRAGDW Sbjct 248 VPPVRFIKTIGDAVMFVCPEPLPMLDVVVKLVDAVDTDNDFPRLRAGVASGMAVSRAGDW 307 Query 314 FGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFR 373 FGSPVNVASRVTGVARPG VL ADSV +A+GD+ + F SFAG RRL+GI+ +V+LFR Sbjct 308 FGSPVNVASRVTGVARPGTVLAADSVWDAVGDSGD---FSGSFAGARRLKGIKNEVKLFR 364 Query 374 VRRG 377 +RRG Sbjct 365 IRRG 368 >gi|254820138|ref|ZP_05225139.1| chain A, Myco adenylyl cyclase, holoenzyme, inhibited state [Mycobacterium intracellulare ATCC 13950] Length=390 Score = 576 bits (1485), Expect = 2e-162, Method: Compositional matrix adjust. Identities = 287/373 (77%), Positives = 322/373 (87%), Gaps = 3/373 (0%) Query 5 VREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG 64 V + DD IDDLL L GTAR ERA+LV WL EQGIT +EIRATNPPLLLATRH++GDDG Sbjct 17 VHDGDDHTIDDLLEGLEGTARTERAELVRWLFEQGITAEEIRATNPPLLLATRHIIGDDG 76 Query 65 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP 124 TYVS REISE +G+DL LLQRVQRA+GL RVDDPDA VHMRADGEAAA QRFVELGL+P Sbjct 77 TYVSTREISETHGIDLGLLQRVQRAIGLVRVDDPDAAVHMRADGEAAAFTQRFVELGLDP 136 Query 125 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD 184 + V+LVVRVLAEGLS AE MRY+AL AIMRPGA+EL+IA+ S+ALV++I P+LGPMIQ Sbjct 137 EHVILVVRVLAEGLSRTAEVMRYSALSAIMRPGASELEIAQASKALVTKIAPMLGPMIQH 196 Query 185 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR 244 MLFMQLRHMMETEAVNA ERAAGKPLPGARQ++VAFADLVGFT++GE V+ EELGHLA R Sbjct 197 MLFMQLRHMMETEAVNAAERAAGKPLPGARQISVAFADLVGFTRIGEAVTPEELGHLANR 256 Query 245 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG 304 LA LARD+T PPV FIKTIGDAVM VCP+P PLLD VLKLVE VD+DN+FPRLRAGVASG Sbjct 257 LAILARDMTVPPVRFIKTIGDAVMFVCPEPQPLLDVVLKLVEAVDSDNDFPRLRAGVASG 316 Query 305 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG 364 MAVSRAGDWFGSPVNVASRVT VARPG VL ADSV E +G+ E F SFAG R L+G Sbjct 317 MAVSRAGDWFGSPVNVASRVTSVARPGTVLAADSVWEVIGERGE---FSASFAGSRHLKG 373 Query 365 IRGDVRLFRVRRG 377 I+G+V+LFR+RRG Sbjct 374 IKGEVKLFRIRRG 386 >gi|336458608|gb|EGO37575.1| family 3 adenylate cyclase [Mycobacterium avium subsp. paratuberculosis S397] Length=371 Score = 575 bits (1483), Expect = 4e-162, Method: Compositional matrix adjust. Identities = 291/373 (79%), Positives = 321/373 (87%), Gaps = 3/373 (0%) Query 5 VREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG 64 + + DD +I+DLL L GTAR ERA+LV WLL QGIT +EIR TNPPLLLATRHL+GDDG Sbjct 1 MHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGITAEEIRTTNPPLLLATRHLIGDDG 60 Query 65 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP 124 TYVS REISE YG+D+ LLQRVQRA+GL RVDDPDA VHMRADGEAAA QRFV++GL+P Sbjct 61 TYVSTREISETYGIDMALLQRVQRAIGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDP 120 Query 125 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD 184 DQVVLV +VLAEGLS AAE MRY+AL AIMRPGATEL+IAK S+ALV+QI PLLGPMIQ Sbjct 121 DQVVLVAQVLAEGLSRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQ 180 Query 185 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR 244 MLFMQLRHMMETEAVNA ERAAGKPLPGARQ+TVAFADLVGFT++GE VS EELG LA R Sbjct 181 MLFMQLRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELGQLANR 240 Query 245 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG 304 LA LARD+T PPV F+KTIGDAVM VCP+P PLLD VLKLVE VDTDN FPRLRAGVASG Sbjct 241 LAILARDVTVPPVRFVKTIGDAVMFVCPEPRPLLDVVLKLVEAVDTDNEFPRLRAGVASG 300 Query 305 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG 364 AVSRAGDWFGSPVNVASRVT VARPG VLVADSV + +GD E F SFAG RRL+G Sbjct 301 TAVSRAGDWFGSPVNVASRVTAVARPGTVLVADSVWDVIGDNGE---FSGSFAGARRLKG 357 Query 365 IRGDVRLFRVRRG 377 I+ +V+LFRVRRG Sbjct 358 IKNEVKLFRVRRG 370 >gi|254774293|ref|ZP_05215809.1| chain A, Myco adenylyl cyclase, holoenzyme, inhibited state [Mycobacterium avium subsp. avium ATCC 25291] Length=385 Score = 573 bits (1476), Expect = 3e-161, Method: Compositional matrix adjust. Identities = 290/365 (80%), Positives = 316/365 (87%), Gaps = 3/365 (0%) Query 13 IDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREI 72 I+DLL L GTAR ERA+LV WLL QGIT +EIR TNPPLLLATRHLVGDDGTYVS REI Sbjct 23 IEDLLDGLQGTARTERAELVRWLLAQGITAEEIRTTNPPLLLATRHLVGDDGTYVSTREI 82 Query 73 SENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVR 132 SE YG+D+ LLQRVQRA+GL RVDDPDA VHMRADGEAAA QRFV++GL+PDQVVLV + Sbjct 83 SETYGIDMALLQRVQRAIGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQVVLVAQ 142 Query 133 VLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRH 192 VLAEGLS AAE MRY+AL AIMRPGATEL+IAK S+ALV+QI PLLGPMIQ MLFMQLRH Sbjct 143 VLAEGLSRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFMQLRH 202 Query 193 MMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDL 252 MMETEAVNA ERAAGKPLPGARQ+TVAFADLVGFT++GE VS EELG LA RLA LARD+ Sbjct 203 MMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELGQLANRLAILARDV 262 Query 253 TAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGD 312 T PPV F+KTIGDAVM VCP+P PLLD VLKLVE VDTDN FPRLRAGVASG AVSRAGD Sbjct 263 TVPPVRFVKTIGDAVMFVCPEPRPLLDVVLKLVEAVDTDNEFPRLRAGVASGTAVSRAGD 322 Query 313 WFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLF 372 WFGSPVNVASRVT VARPG VLVADSV + +GD E F SFAG RRL+GI+ +V+LF Sbjct 323 WFGSPVNVASRVTAVARPGTVLVADSVWDVIGDNGE---FSGSFAGARRLKGIKNEVKLF 379 Query 373 RVRRG 377 RVRRG Sbjct 380 RVRRG 384 >gi|342862143|ref|ZP_08718786.1| chain A, Myco adenylyl cyclase, holoenzyme, inhibited state [Mycobacterium colombiense CECT 3035] gi|342130447|gb|EGT83762.1| chain A, Myco adenylyl cyclase, holoenzyme, inhibited state [Mycobacterium colombiense CECT 3035] Length=378 Score = 572 bits (1475), Expect = 3e-161, Method: Compositional matrix adjust. Identities = 287/373 (77%), Positives = 327/373 (88%), Gaps = 3/373 (0%) Query 5 VREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG 64 V++ D +IDDLL L G+AR ERA+LV+WL EQG++ +EI ATNPPLLLATRHL+GDDG Sbjct 6 VQDGADHDIDDLLEGLEGSARTERAELVKWLFEQGVSAEEICATNPPLLLATRHLMGDDG 65 Query 65 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP 124 TYVS REISE +G+DL LLQ+VQRA+GL RVDDPDA VHMRADGEAAA QRFVELGL+P Sbjct 66 TYVSTREISEAHGIDLGLLQQVQRAIGLVRVDDPDAAVHMRADGEAAAFTQRFVELGLDP 125 Query 125 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD 184 +Q+VLVVRVLAEGLS AAE MRYTAL AIMRPGATEL+IA+ S+ALV++I P+LGPM++ Sbjct 126 EQLVLVVRVLAEGLSRAAEVMRYTALSAIMRPGATELEIAQASKALVAEIAPMLGPMVEH 185 Query 185 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR 244 MLFMQLRHMMETEA+NA ERAAGKPLPGARQ+TVAFADLVGFT++GE VS EELGHLA R Sbjct 186 MLFMQLRHMMETEAINAAERAAGKPLPGARQITVAFADLVGFTKIGEAVSPEELGHLANR 245 Query 245 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG 304 LA LARD+T PPV FIKTIGDAVMLVCPDP PLLD ++KLVE VDTDN+FPRLRAGVASG Sbjct 246 LAILARDMTVPPVRFIKTIGDAVMLVCPDPLPLLDVIVKLVEAVDTDNDFPRLRAGVASG 305 Query 305 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG 364 MAVSRAGDWFGSPVNVASRVT VARPG VLVADSV + +GD + F SFAG RRL+G Sbjct 306 MAVSRAGDWFGSPVNVASRVTNVARPGTVLVADSVWDVIGDRGQ---FSGSFAGARRLKG 362 Query 365 IRGDVRLFRVRRG 377 I+ +V+LFRVRRG Sbjct 363 IKSEVKLFRVRRG 375 >gi|41408605|ref|NP_961441.1| hypothetical protein MAP2507c [Mycobacterium avium subsp. paratuberculosis K-10] gi|118463572|ref|YP_880657.1| chain A, Myco adenylyl cyclase, holoenzyme, inhibited state [Mycobacterium avium 104] gi|41396963|gb|AAS04824.1| hypothetical protein MAP_2507c [Mycobacterium avium subsp. paratuberculosis K-10] gi|118164859|gb|ABK65756.1| chain A, Mycobacterial Adenylyl Cyclase , Holoenzyme, Inhibited State [Mycobacterium avium 104] Length=385 Score = 572 bits (1474), Expect = 4e-161, Method: Compositional matrix adjust. Identities = 289/365 (80%), Positives = 316/365 (87%), Gaps = 3/365 (0%) Query 13 IDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREI 72 I+DLL L GTAR ERA+LV WLL QGIT +EIR TNPPLLLATRHL+GDDGTYVS REI Sbjct 23 IEDLLDGLQGTARTERAELVRWLLAQGITAEEIRTTNPPLLLATRHLIGDDGTYVSTREI 82 Query 73 SENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVR 132 SE YG+D+ LLQRVQRA+GL RVDDPDA VHMRADGEAAA QRFV++GL+PDQVVLV + Sbjct 83 SETYGIDMALLQRVQRAIGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQVVLVAQ 142 Query 133 VLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRH 192 VLAEGLS AAE MRY+AL AIMRPGATEL+IAK S+ALV+QI PLLGPMIQ MLFMQLRH Sbjct 143 VLAEGLSRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQMLFMQLRH 202 Query 193 MMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDL 252 MMETEAVNA ERAAGKPLPGARQ+TVAFADLVGFT++GE VS EELG LA RLA LARD+ Sbjct 203 MMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSPEELGQLANRLAILARDV 262 Query 253 TAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGD 312 T PPV F+KTIGDAVM VCP+P PLLD VLKLVE VDTDN FPRLRAGVASG AVSRAGD Sbjct 263 TVPPVRFVKTIGDAVMFVCPEPRPLLDVVLKLVEAVDTDNEFPRLRAGVASGTAVSRAGD 322 Query 313 WFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLF 372 WFGSPVNVASRVT VARPG VLVADSV + +GD E F SFAG RRL+GI+ +V+LF Sbjct 323 WFGSPVNVASRVTAVARPGTVLVADSVWDVIGDNGE---FSGSFAGARRLKGIKNEVKLF 379 Query 373 RVRRG 377 RVRRG Sbjct 380 RVRRG 384 >gi|333989874|ref|YP_004522488.1| adenylate cyclase CyaA [Mycobacterium sp. JDM601] gi|333485842|gb|AEF35234.1| adenylate cyclase CyaA [Mycobacterium sp. JDM601] Length=370 Score = 474 bits (1219), Expect = 1e-131, Method: Compositional matrix adjust. Identities = 243/369 (66%), Positives = 292/369 (80%), Gaps = 3/369 (0%) Query 10 DANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSA 69 D ID+LL L G ARAERA+L+EWLL QGI+ +EIR + P+LLA+R L+GDDG+YVSA Sbjct 3 DPQIDELLDGLDGVARAERAELIEWLLGQGISAEEIRVSASPMLLASRRLIGDDGSYVSA 62 Query 70 REISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVL 129 R+ISE+ GVDLELLQR+QRAVGL VDDPDA V MRADG A A+RF+E G++ + + Sbjct 63 RDISESAGVDLELLQRLQRAVGLPWVDDPDAAVQMRADGNVAVHARRFLEAGIDAEHALQ 122 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ 189 +RVLA+GL+HA + MR L AI+ PGATEL IA+ SQ LV ++ PLLGP +QDML MQ Sbjct 123 TLRVLADGLAHAVDPMRAAMLAAIVEPGATELQIAQRSQELVGRLAPLLGPFVQDMLLMQ 182 Query 190 LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLA 249 LRH +T+AVNAGERAAG PLPGAR +TVAFADLVGFT+LGE+V EEL LA RL GLA Sbjct 183 LRHQFDTDAVNAGERAAGAPLPGARHITVAFADLVGFTRLGEMVPPEELVQLAERLTGLA 242 Query 250 RDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSR 309 R++ PPV FIKTIGDAVM VCP+PAPL+D VL+LVEV +D + PRLRAGVA+G AVSR Sbjct 243 REIAVPPVRFIKTIGDAVMFVCPEPAPLVDAVLRLVEVAASDESLPRLRAGVAAGEAVSR 302 Query 310 AGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDV 369 GDWFGSPVN+ASRVT ARPG+VLVA V+ AL D D F+WSFAG R L+GI+G+V Sbjct 303 VGDWFGSPVNLASRVTSAARPGSVLVAGPVQAALVD---DDAFRWSFAGARHLKGIKGEV 359 Query 370 RLFRVRRGA 378 +FRVRR A Sbjct 360 SVFRVRRAA 368 >gi|126436538|ref|YP_001072229.1| putative adenylate/guanylate cyclase [Mycobacterium sp. JLS] gi|126236338|gb|ABN99738.1| putative adenylate/guanylate cyclase [Mycobacterium sp. JLS] Length=373 Score = 441 bits (1133), Expect = 1e-121, Method: Compositional matrix adjust. Identities = 244/368 (67%), Positives = 292/368 (80%), Gaps = 3/368 (0%) Query 9 DDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVS 68 D +I+ LL L GTAR+ERA+L+EWLL +G T E+ P+LLA+R VGDDG YVS Sbjct 6 DTEDIEGLLVGLTGTARSERAELIEWLLGRGFTMAEVHEAIAPMLLASRRHVGDDGVYVS 65 Query 69 AREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVV 128 ARE SE +G+DL+LLQRVQRA+GL+R DDPDAVVH+RAD EAAARAQRF++ GL+PDQVV Sbjct 66 ARETSEKFGIDLDLLQRVQRAMGLSREDDPDAVVHLRADAEAAARAQRFIDFGLDPDQVV 125 Query 129 LVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM 188 VVRVL+EGL+ AAE MRYTA A++ PGATEL IAK S+ALV ++ P+LGPM++DML + Sbjct 126 QVVRVLSEGLAKAAEVMRYTAFAAVLTPGATELQIAKKSEALVRELAPMLGPMVEDMLLL 185 Query 189 QLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGL 248 QLRH METEAV+A ERA G PLPGARQVTV FADLVGFT+LGE V E+L LA RL L Sbjct 186 QLRHAMETEAVSATERAEGLPLPGARQVTVMFADLVGFTRLGEAVPPEKLEQLARRLGDL 245 Query 249 ARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVS 308 AR+L PV F+KTIGDAVMLV DPA LL+ L L++ +D FPRLR G+A G AVS Sbjct 246 ARELAVAPVRFVKTIGDAVMLVSTDPAALLEAALALLDAATSDAEFPRLRVGLAVGQAVS 305 Query 309 RAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGD 368 RAGDWFGSPVN+ASRVTG ARPG VLV++SVREA+GD + F WS+AG R L+GIRG+ Sbjct 306 RAGDWFGSPVNLASRVTGAARPGTVLVSESVREAVGD---DERFSWSYAGARHLKGIRGE 362 Query 369 VRLFRVRR 376 V+LFR RR Sbjct 363 VKLFRARR 370 >gi|108800913|ref|YP_641110.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS] gi|119870053|ref|YP_940005.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] gi|108771332|gb|ABG10054.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS] gi|119696142|gb|ABL93215.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] Length=373 Score = 439 bits (1129), Expect = 4e-121, Method: Compositional matrix adjust. Identities = 243/368 (67%), Positives = 292/368 (80%), Gaps = 3/368 (0%) Query 9 DDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVS 68 D +I+ LL L GTAR+ERA+L+EWLL +G T E+ P+LLA+R VGDDG YVS Sbjct 6 DTEDIEGLLVGLTGTARSERAELIEWLLGRGFTMAEVHEAIAPMLLASRRHVGDDGVYVS 65 Query 69 AREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVV 128 ARE SE +G+DL+LLQRVQRA+GL+R DDPDAVVH+RAD EAAARAQRF++ GL+PDQVV Sbjct 66 ARETSEKFGIDLDLLQRVQRAMGLSREDDPDAVVHLRADAEAAARAQRFIDFGLDPDQVV 125 Query 129 LVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM 188 VVRVL+EGL+ AAE MRYTA A++ PGATEL IAK S+ALV ++ P+LGPM++DML + Sbjct 126 QVVRVLSEGLAKAAEVMRYTAFAAVLTPGATELQIAKKSEALVRELAPMLGPMVEDMLLL 185 Query 189 QLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGL 248 QLRH METEAV+A ERA G PLPGAR+VTV FADLVGFT+LGE V E+L LA RL L Sbjct 186 QLRHAMETEAVSATERAEGLPLPGAREVTVMFADLVGFTRLGEAVPPEKLEQLARRLGDL 245 Query 249 ARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVS 308 AR+L PV F+KTIGDAVMLV DPA LL+ L L++ +D FPRLR G+A G AVS Sbjct 246 ARELAVAPVRFVKTIGDAVMLVSTDPAALLEAALALLDAATSDAEFPRLRVGLAVGQAVS 305 Query 309 RAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGD 368 RAGDWFGSPVN+ASRVTG ARPG VLV++SVREA+GD + F WS+AG R L+GIRG+ Sbjct 306 RAGDWFGSPVNLASRVTGAARPGTVLVSESVREAVGD---DERFSWSYAGARHLKGIRGE 362 Query 369 VRLFRVRR 376 V+LFR RR Sbjct 363 VKLFRARR 370 >gi|120405404|ref|YP_955233.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii PYR-1] gi|119958222|gb|ABM15227.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii PYR-1] Length=373 Score = 439 bits (1129), Expect = 4e-121, Method: Compositional matrix adjust. Identities = 221/367 (61%), Positives = 286/367 (78%), Gaps = 3/367 (0%) Query 10 DANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSA 69 D +LL L G AR ERA+L+ WL+ +G+ D+IR P+LLA+R ++GDDG YVSA Sbjct 6 DLETSELLDGLEGDARGERAELIRWLVGRGVGIDQIRGNPAPMLLASRRVIGDDGLYVSA 65 Query 70 REISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVL 129 R+ + N GVDLEL +R+QRA+GL RVDD DA V +RAD EAA + F++ G++PD++V Sbjct 66 RQAAANAGVDLELFERIQRAMGLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDELVQ 125 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ 189 + R+L +GLS AAEAMRY AL A++RPGATEL+IA+ S+ALV+ + PLLGPMIQ++L +Q Sbjct 126 ITRLLGDGLSRAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEVLLLQ 185 Query 190 LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLA 249 LRH +ETEAVNA ERA G+ LPGAR VT+ FADLVGFT+LGE V E+L L+ RLA + Sbjct 186 LRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPPEDLEQLSQRLADMT 245 Query 250 RDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSR 309 R+ PV FIKTIGD VMLV P+PAPLLDT+L+LV+ + D++FPRLRAGVA+G+AVSR Sbjct 246 REFAVAPVRFIKTIGDEVMLVSPEPAPLLDTLLRLVDETEDDDDFPRLRAGVATGLAVSR 305 Query 310 AGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDV 369 AGDWFGSPVN+A+RVTG ARPG+VLVA++ REA+G E + F WSFAG + L+G + DV Sbjct 306 AGDWFGSPVNLAARVTGAARPGSVLVAEATREAIG---EDERFTWSFAGGKHLKGFKSDV 362 Query 370 RLFRVRR 376 + FR RR Sbjct 363 KTFRARR 369 >gi|289573924|ref|ZP_06454151.1| LOW QUALITY PROTEIN: adenylyl cyclase [Mycobacterium tuberculosis K85] gi|289538355|gb|EFD42933.1| LOW QUALITY PROTEIN: adenylyl cyclase [Mycobacterium tuberculosis K85] Length=226 Score = 435 bits (1118), Expect = 8e-120, Method: Compositional matrix adjust. Identities = 219/219 (100%), Positives = 219/219 (100%), Gaps = 0/219 (0%) Query 179 GPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL 238 GPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL Sbjct 8 GPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL 67 Query 239 GHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLR 298 GHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLR Sbjct 68 GHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLR 127 Query 299 AGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAG 358 AGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAG Sbjct 128 AGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAG 187 Query 359 PRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 397 PRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP Sbjct 188 PRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP 226 >gi|315443297|ref|YP_004076176.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1] gi|315261600|gb|ADT98341.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1] Length=375 Score = 434 bits (1116), Expect = 1e-119, Method: Compositional matrix adjust. Identities = 220/369 (60%), Positives = 284/369 (77%), Gaps = 3/369 (0%) Query 7 EADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTY 66 E D LL L G ARAERA+L+ WLL++G+ DEIR P+LLA+R ++GDDG Y Sbjct 3 EEFDVETSGLLDGLEGAARAERAELIGWLLDRGVAVDEIRGNPAPMLLASRRVIGDDGEY 62 Query 67 VSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQ 126 VSAR+ ++ GV+LEL +R+QRA+GL RV+DPDA V +RAD EAA + F+++G+ D+ Sbjct 63 VSARQAADRAGVELELFERIQRAMGLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDE 122 Query 127 VVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDML 186 +V + R+L +GL+ AAEAMRY AL A++RP ATEL+ AK S+ LV + PLLGPMIQ++L Sbjct 123 LVQITRLLGDGLARAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEVL 182 Query 187 FMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLA 246 +QLRH +ETEA+NA ERA G+ LPGAR VT+ FADLVGFT+LGE + E+L LA RLA Sbjct 183 LLQLRHAIETEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPPEDLERLAQRLA 242 Query 247 GLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMA 306 L R++ PV FIKTIGD VMLV P+PAPLL+T+L+LVE + D++FPRLRAGVA+GMA Sbjct 243 DLTREIAVAPVRFIKTIGDEVMLVSPEPAPLLETMLRLVEETEGDDDFPRLRAGVATGMA 302 Query 307 VSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIR 366 VSRAGDWFGSPVN+A+R+TG ARPG VLVA++ REA+G E D F WSFAG + L+GI+ Sbjct 303 VSRAGDWFGSPVNLAARMTGAARPGTVLVAEAAREAIG---EDDRFAWSFAGAKHLKGIK 359 Query 367 GDVRLFRVR 375 DV+ FR R Sbjct 360 SDVKSFRAR 368 >gi|145222831|ref|YP_001133509.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK] gi|145215317|gb|ABP44721.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK] Length=369 Score = 432 bits (1112), Expect = 3e-119, Method: Compositional matrix adjust. Identities = 218/360 (61%), Positives = 282/360 (79%), Gaps = 3/360 (0%) Query 16 LLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREISEN 75 LL L G ARAERA+L+ WLL++G+ DEIR P+LLA+R ++GDDG YVSAR+ ++ Sbjct 6 LLDGLEGAARAERAELIGWLLDRGVAVDEIRGNPAPMLLASRRVIGDDGEYVSARQAADR 65 Query 76 YGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLA 135 GV+LEL +R+QRA+GL RV+DPDA V +RAD EAA + F+++G+ D++V + R+L Sbjct 66 AGVELELFERIQRAMGLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDELVQITRLLG 125 Query 136 EGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMME 195 +GL+ AAEAMRY AL A++RP ATEL+ AK S+ LV + PLLGPMIQ++L +QLRH +E Sbjct 126 DGLARAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEVLLLQLRHAIE 185 Query 196 TEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAP 255 TEA+NA ERA G+ LPGAR VT+ FADLVGFT+LGE + E+L LA RLA L R++ Sbjct 186 TEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPPEDLERLAQRLADLTREIAVA 245 Query 256 PVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFG 315 PV FIKTIGD VMLV P+PAPLL+T+L+LVE + D++FPRLRAGVA+GMAVSRAGDWFG Sbjct 246 PVRFIKTIGDEVMLVSPEPAPLLETMLRLVEETEGDDDFPRLRAGVATGMAVSRAGDWFG 305 Query 316 SPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVR 375 SPVN+A+R+TG ARPG VLVA++ REA+G E D F WSFAG + L+GI+ DV+ FR R Sbjct 306 SPVNLAARMTGAARPGTVLVAEAAREAIG---EDDRFAWSFAGAKHLKGIKSDVKSFRAR 362 >gi|118467881|ref|YP_889269.1| adenylate and guanylate cyclase catalytic domain-containing protein [Mycobacterium smegmatis str. MC2 155] gi|118169168|gb|ABK70064.1| Adenylate and Guanylate cyclase catalytic domain protein [Mycobacterium smegmatis str. MC2 155] Length=374 Score = 432 bits (1111), Expect = 4e-119, Method: Compositional matrix adjust. Identities = 233/364 (65%), Positives = 284/364 (79%), Gaps = 2/364 (0%) Query 12 NIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSARE 71 +I LL L G AR++R +L+ WLL +GI+ D+I P+LLA+R + GDDGTYVSARE Sbjct 9 DIQPLLEGLDGAARSQREELINWLLSRGISVDQIGQAITPMLLASRRVAGDDGTYVSARE 68 Query 72 ISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVV 131 ISE G+DL+LLQR+QRA+GL V+DPDA V +RAD EA +Q+F++LG++ DQVVL+ Sbjct 69 ISEQTGLDLDLLQRLQRAMGLPAVEDPDAAVLLRADAEAVTFSQQFIDLGIDADQVVLIT 128 Query 132 RVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLR 191 RVLAEGLS AAE MR AL A++ PGA+EL+ AK ++ LV++ PLLGPMIQDMLF+QLR Sbjct 129 RVLAEGLSRAAEVMRAAALAAVLEPGASELETAKAAEGLVAEAAPLLGPMIQDMLFVQLR 188 Query 192 HMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARD 251 H METEAV+A ERA G PLPGAR VTVAFAD+VGFT+LGEVV E+L LA LA RD Sbjct 189 HAMETEAVDASERAEGVPLPGARLVTVAFADIVGFTRLGEVVPPEQLEQLANSLAEATRD 248 Query 252 LTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAG 311 + PPV IKTIGDAVMLV P+PA LLD VL LV + D FP LR G+A+GMAVSRAG Sbjct 249 VVRPPVRLIKTIGDAVMLVSPEPAALLDAVLNLVAATEADPEFPGLRVGLATGMAVSRAG 308 Query 312 DWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRL 371 DWFGSPVN+ASRVTGVARPG VLVA+S R+A+ A D F+WSFAG RRL+GI+GDV++ Sbjct 309 DWFGSPVNLASRVTGVARPGTVLVAESTRQAIAAAD--DRFRWSFAGARRLKGIKGDVKM 366 Query 372 FRVR 375 FR R Sbjct 367 FRAR 370 >gi|119389357|pdb|2EV1|A Chain A, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, At Ph 6.0 gi|119389358|pdb|2EV1|B Chain B, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, At Ph 6.0 gi|119389359|pdb|2EV2|A Chain A, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, At Ph 8.5 gi|119389360|pdb|2EV2|B Chain B, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, At Ph 8.5 gi|119389361|pdb|2EV3|A Chain A, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, At Ph 5.3 gi|119389362|pdb|2EV3|B Chain B, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, At Ph 5.3 gi|119389363|pdb|2EV4|A Chain A, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, With A Salt Precipitant gi|119389364|pdb|2EV4|B Chain B, Structure Of Rv1264n, The Regulatory Domain Of The Mycobacterial Adenylyl Cylcase Rv1264, With A Salt Precipitant Length=222 Score = 407 bits (1046), Expect = 2e-111, Method: Compositional matrix adjust. Identities = 206/208 (99%), Positives = 207/208 (99%), Gaps = 0/208 (0%) Query 1 VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 60 +TDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV Sbjct 13 MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV 72 Query 61 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 120 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL Sbjct 73 GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL 132 Query 121 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 180 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP Sbjct 133 GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP 192 Query 181 MIQDMLFMQLRHMMETEAVNAGERAAGK 208 MIQDMLFMQLRHMMETEAVNAGERAAG Sbjct 193 MIQDMLFMQLRHMMETEAVNAGERAAGS 220 >gi|240170700|ref|ZP_04749359.1| adenylyl cyclase (ATP pyrophosphate-lyase) [Mycobacterium kansasii ATCC 12478] Length=380 Score = 382 bits (980), Expect = 7e-104, Method: Compositional matrix adjust. Identities = 212/375 (57%), Positives = 264/375 (71%), Gaps = 7/375 (1%) Query 7 EADDANIDDL--LGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDG 64 E D+ +++ L L L G AR ERA+L+ WLL++G D+IR P+LL +GDDG Sbjct 10 EPDNNDVESLGLLDHLDGRARQERAELINWLLDRGFDVDQIRDAFIPMLLPANRAIGDDG 69 Query 65 TYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNP 124 T VSAREISE+ GV LELLQR+ RA GL RV DPD+ + RAD EA A R V+LGL+P Sbjct 70 TTVSAREISESSGVSLELLQRLHRAAGLVRVYDPDSPLRSRADAEAVLNAARLVDLGLDP 129 Query 125 DQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQD 184 +V LVVR+L EGL+ A A+R AL+A + PGATEL++AK + L Q PLLGPM+ D Sbjct 130 ARVGLVVRLLVEGLTGPAVALRRAALQASLSPGATELELAKAFEHLARQAEPLLGPMVDD 189 Query 185 MLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGR 244 +L + LRH ETEA+N ERAAG LPGAR V VAFADLVGFT+LGE + ++LG +A R Sbjct 190 LLRLVLRHSFETEAINVAERAAGT-LPGARDVAVAFADLVGFTRLGEQLPPDDLGLIAFR 248 Query 245 LAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASG 304 L+ LA D+T PV F+KTIGDAVMLVC +P LL TVL LVE + RLR G A G Sbjct 249 LSDLAHDVTTSPVQFVKTIGDAVMLVCAEPPQLLTTVLDLVEAAAAEKIL-RLRVGFAFG 307 Query 305 MAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRG 364 A+SR+GDW+GSPVN+ASR+T A GAV + ++ REA+GDAP G +WSF G R LRG Sbjct 308 RAISRSGDWYGSPVNMASRITHAAPSGAVWLTEAAREAIGDAP---GLEWSFVGARHLRG 364 Query 365 IRGDVRLFRVRRGAT 379 I G+VRL+ VRR AT Sbjct 365 IHGEVRLYAVRRAAT 379 >gi|183980191|ref|YP_001848482.1| adenylate cyclase, CyaA [Mycobacterium marinum M] gi|183173517|gb|ACC38627.1| adenylate cyclase, CyaA [Mycobacterium marinum M] Length=374 Score = 347 bits (890), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 195/366 (54%), Positives = 261/366 (72%), Gaps = 7/366 (1%) Query 10 DANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNP-PLLLATRHLVGDDGTYVS 68 D LL L GTAR +RA+L+ WLLE+G + + I+A+ P++L ++GDDGT VS Sbjct 6 DIEASGLLDGLEGTARQDRAELIAWLLERGFSLEHIQASAAAPVMLPAYRVLGDDGTLVS 65 Query 69 AREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVV 128 AREI G++L++LQR+QRAVGL R+DDPD V RAD EA A+ F+++G + + V Sbjct 66 AREICAATGIELDVLQRLQRAVGLPRIDDPDEAVLPRADAEAVRHAKVFLDIGYDLEDAV 125 Query 129 LVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM 188 V+RVL E L HAA MR AL+ ++RPG +E+++A+ S+ L +PLL PM+ D++ + Sbjct 126 AVMRVLVESLGHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRL 185 Query 189 QLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGL 248 +LRH +ETEAVNA ERAAG LPGAR VTVAFAD+ GFT+LGEV+ AE+L +A RLA L Sbjct 186 ELRHSVETEAVNAAERAAGT-LPGARPVTVAFADMAGFTRLGEVMPAEDLERVAARLADL 244 Query 249 ARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVS 308 A D PV F+K+IGDAVMLVCP+PAPLL L L + R+ GVASG AV+ Sbjct 245 AHDAATMPVRFVKSIGDAVMLVCPEPAPLLRAALDLAAAAANNLPPLRI--GVASGAAVT 302 Query 309 RAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGD 368 RAGDWFGSPVN+ASRVT +A PG V+VA+S R+A+G+A + F+W G +R+RG+R + Sbjct 303 RAGDWFGSPVNLASRVTSIAYPGTVVVAESTRDAVGNAGD---FEWFSIGAQRIRGMRAE 359 Query 369 VRLFRV 374 V+LFRV Sbjct 360 VKLFRV 365 >gi|118619965|ref|YP_908297.1| adenylate cyclase, CyaA [Mycobacterium ulcerans Agy99] gi|118572075|gb|ABL06826.1| adenylate cyclase, CyaA [Mycobacterium ulcerans Agy99] Length=374 Score = 345 bits (886), Expect = 6e-93, Method: Compositional matrix adjust. Identities = 194/366 (54%), Positives = 260/366 (72%), Gaps = 7/366 (1%) Query 10 DANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNP-PLLLATRHLVGDDGTYVS 68 D LL L GTAR +RA+L+ WLLE+G + + I+A+ P++L ++GDDGT VS Sbjct 6 DIEASGLLDGLEGTARQDRAELIAWLLERGFSFEHIQASAAAPVMLPAYRVLGDDGTLVS 65 Query 69 AREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVV 128 AREI G++L++LQR+QRAV L R+DDPD V RAD EA A+ F+++G + + V Sbjct 66 AREICAATGIELDVLQRLQRAVSLPRIDDPDEAVLPRADAEAVRHAKVFLDIGYDLEDAV 125 Query 129 LVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFM 188 V+RVL E L HAA MR AL+ ++RPG +E+++A+ S+ L +PLL PM+ D++ + Sbjct 126 AVMRVLVESLGHAAAMMREAALKTLLRPGFSEIELAEASEQLAQAAIPLLPPMMDDLMRL 185 Query 189 QLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGL 248 +LRH +ETEAVNA ERAAG LPGAR VTVAFAD+ GFT+LGEV+ AE+L +A RLA L Sbjct 186 ELRHSVETEAVNAAERAAGT-LPGARPVTVAFADMAGFTRLGEVMPAEDLERVAARLADL 244 Query 249 ARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVS 308 A D PV F+K+IGDAVMLVCP+PAPLL L L + R+ GVASG AV+ Sbjct 245 AHDAATMPVRFVKSIGDAVMLVCPEPAPLLRAALDLAAAAANNLPPLRI--GVASGAAVT 302 Query 309 RAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGD 368 RAGDWFGSPVN+ASRVT +A PG V+VA+S R+A+G+A + F+W G +R+RG+R + Sbjct 303 RAGDWFGSPVNLASRVTSIAYPGTVVVAESTRDAVGNAGD---FEWFSIGAQRIRGMRAE 359 Query 369 VRLFRV 374 V+LFRV Sbjct 360 VKLFRV 365 >gi|284046120|ref|YP_003396460.1| adenylate/guanylate cyclase [Conexibacter woesei DSM 14684] gi|283950341|gb|ADB53085.1| adenylate/guanylate cyclase [Conexibacter woesei DSM 14684] Length=373 Score = 243 bits (621), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 162/378 (43%), Positives = 226/378 (60%), Gaps = 16/378 (4%) Query 2 TDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIR---ATNPPLLLATRH 58 TD+ E +DD ARAER L++ L+ +G+ E+R A + LL Sbjct 4 TDYAAEGLLEGLDD-----DAQARAERIALLDRLVAEGVPLPELRRAAAEDRLALLQVER 58 Query 59 LVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFV 118 ++G + + RE++ G+ +EL+ R ++A+GL R DPD V +D E AAR + F Sbjct 59 MLGTE--EYTPREVAARVGLPVELILRHRQALGLPR-PDPDDRVLTESDIETAARLKAFH 115 Query 119 ELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLL 178 GL+ ++ V RVL EGL+ A +R + + PG E +++ +Q+ P L Sbjct 116 AAGLSEQGILEVSRVLGEGLARVAATLRPLVRDTFLEPGIGERELSDRYATASAQLGPQL 175 Query 179 GPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEEL 238 G ++Q +L M LR + T+ V E G L GA ++++AFADLVGFT+LGE V AEEL Sbjct 176 GVVMQHILNMHLRDQLRTDVVGRAELVRGGVL-GAVEMSIAFADLVGFTKLGERVPAEEL 234 Query 239 GHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTD-NNFPRL 297 G +AGRL LA + PPV +K+IGDAVMLV PDP LL T L++V D + FPRL Sbjct 235 GAIAGRLTELAVEAAQPPVRLVKSIGDAVMLVSPDPDALLATSLEIVAAADAEGEEFPRL 294 Query 298 RAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFA 357 RAGVA+G + RAGDW+GSPVN+ASR+TGVAR G+V+ A + R+A A +D + WS Sbjct 295 RAGVATGPVLGRAGDWYGSPVNLASRITGVARSGSVVAAGATRDA---ATASDRWAWSPL 351 Query 358 GPRRLRGIRGDVRLFRVR 375 RRLRG+ V LFRVR Sbjct 352 PARRLRGVDHPVPLFRVR 369 >gi|111018939|ref|YP_701911.1| adenylate cyclase [Rhodococcus jostii RHA1] gi|110818469|gb|ABG93753.1| probable adenylate cyclase [Rhodococcus jostii RHA1] Length=400 Score = 172 bits (437), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 139/367 (38%), Positives = 190/367 (52%), Gaps = 19/367 (5%) Query 16 LLGDLGGTARAERAKLVEWLLEQGITPDEIRA---TNPPLLLATRHLVGDDGTYVSAREI 72 LL L G+ R+ R ++ L+E G++ DE+RA N L H + G Y EI Sbjct 43 LLDGLSGSDRSARMGVLNTLIEDGVSIDELRAASRNNRLAHLLLEHALAPKGRY-GIDEI 101 Query 73 SENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVR 132 SE GV +E +R RA+G R D + D + A +++ +LGL+ + R Sbjct 102 SEKTGVTVEDARRWFRAIG--RGASEDGTFYDDGDLDLARGLKQYRDLGLDESGIFAAAR 159 Query 133 VLAEGL---SHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ 189 VL L + AA+A+ LEA ++A V +I ++ ++ Sbjct 160 VLGRNLWTVADAADALLQERLEATR----DHPEVALRYAVEVRRIADFEAQILAHLIATT 215 Query 190 LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLA 249 LRH + ++AV R + + GA+++ V FADLVGFT LGE V+ +LG +A RL GLA Sbjct 216 LRHQLRSDAVGIA-RDSNLQVRGAQEIGVCFADLVGFTLLGEQVAPADLGRVAERLDGLA 274 Query 250 RDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSR 309 DL PPV +KTIGDAVMLV PDP L T L LV+ + P LRAG+A G AV Sbjct 275 TDLVLPPVRLVKTIGDAVMLVSPDPNALAYTALDLVQAARAE-GLPPLRAGIAWGTAVPS 333 Query 310 AGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDV 369 AGDWFG PVN+ASRV VA V+V + L + D F AG RL+GI Sbjct 334 AGDWFGRPVNMASRVVAVAPSHEVVVTGEFYDEL----DTDEFWGEPAGSHRLKGIDVPQ 389 Query 370 RLFRVRR 376 LF + R Sbjct 390 ELFGIGR 396 >gi|226361039|ref|YP_002778817.1| adenylate cyclase [Rhodococcus opacus B4] gi|226239524|dbj|BAH49872.1| putative adenylate cyclase [Rhodococcus opacus B4] Length=383 Score = 152 bits (384), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 129/368 (36%), Positives = 187/368 (51%), Gaps = 21/368 (5%) Query 16 LLGDLGGTARAERAKLVEWLLEQGITPDEIRAT---NPPLLLATRHLVGDDGTYVSAREI 72 LL L G R+ R ++ L+E G + D++R + L H + G Y S +I Sbjct 26 LLDGLSGPDRSARMGVLNTLIEDGASIDDLRGAARGDRLAHLLLEHALSPKGRY-SIDDI 84 Query 73 SENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVR 132 + GV ++ +R RA+G R D + D + A +++ +LGL+ + R Sbjct 85 ARKVGVTVDDARRWFRAIG--RGASSDGTFYDDGDLDLARGLEQYRDLGLDESAIFAAAR 142 Query 133 VLAEGL---SHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ 189 VL L + AA+++ LEA L A V +IV ++ ++ Sbjct 143 VLGRNLWTVAGAADSLLQERLEATREHPEVALRYA----VEVRRIVDFEAQILAHLIATA 198 Query 190 LRHMMETEAVN-AGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGL 248 LRH + ++AV AG+ + + GA++V V FADLVGFT LGE + +LG +A RL + Sbjct 199 LRHQLRSDAVGIAGD--SNLRVRGAQEVGVCFADLVGFTLLGEQAAPADLGRVAERLDRV 256 Query 249 ARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVS 308 A DL +PPV +KTIGDAVM+V PDP L L LV+ T+ P+LRAG+A G AV Sbjct 257 ATDLVSPPVRLVKTIGDAVMMVSPDPNALAHVALDLVQAARTE-GLPQLRAGIAWGTAVP 315 Query 309 RAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGD 368 AGDWFG PV A RV VA V+V + L ++D F AG +L GI Sbjct 316 SAGDWFGRPVGTAGRVVAVAPSQEVVVTGEFYDEL----DSDEFWGEPAGSHQLEGIDAP 371 Query 369 VRLFRVRR 376 +LF + R Sbjct 372 QKLFGIGR 379 >gi|333922036|ref|YP_004495617.1| putative adenylate cyclase [Amycolicicoccus subflavus DQS3-9A1] gi|333484257|gb|AEF42817.1| putative adenylate cyclase [Amycolicicoccus subflavus DQS3-9A1] Length=385 Score = 142 bits (357), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 118/363 (33%), Positives = 179/363 (50%), Gaps = 14/363 (3%) Query 16 LLGDLGGTARAERAKLVEWLLEQGITPDEIRATNP----PLLLATRHLVGDDGTYVSARE 71 LL L ARA R ++ L+ +G++ DE+++ P+L+ H + GT A + Sbjct 22 LLDGLNDKARALRVVALDALICEGVSVDELKSATADGRLPMLI-LEHALEPPGTLTLA-D 79 Query 72 ISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVV 131 ++E VD LL+ RA+G D DA V+ D A + ++ LG +Q+ + Sbjct 80 LAEKAAVDEALLRSWFRALGRGVPGD-DAPVYNTDDVMVAQQLADYLALGFEFEQLHALA 138 Query 132 RVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLR 191 RV L+ + + + + R + D+ V + + ++ +L L Sbjct 139 RVWGRNLASFIDGLAELVADGLSR-AEGDTDVILRYALEVRRFAEVEAQVLGHILGTTLA 197 Query 192 HMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARD 251 + +EAV+ + + + G + V FADLVGFT+LG + AE LG +A L+ LA + Sbjct 198 QRIRSEAVSTANKQNMR-IGGTQDVAFCFADLVGFTKLGGQLPAEVLGGVADELSALATE 256 Query 252 LTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAG 311 L PPV KTIGDAVML+ PD ++ ++LV+ T P LRA V G AV R+G Sbjct 257 LVDPPVRVFKTIGDAVMLMSPDVDAIVAVAVRLVDQAQT-RGLPPLRASVTFGKAVPRSG 315 Query 312 DWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRL 371 DW+G P+N+ASR VA G V V V E L ADGF G +G+ D + Sbjct 316 DWYGHPINLASRALSVATAGQVAVTKEVVERL----NADGFTIEPLGAFAFKGVDTDTEM 371 Query 372 FRV 374 F V Sbjct 372 FAV 374 >gi|226349941|ref|YP_002777054.1| hypothetical protein ROP_pROB02-01100 [Rhodococcus opacus B4] gi|226245856|dbj|BAH47123.1| hypothetical protein [Rhodococcus opacus B4] Length=397 Score = 135 bits (339), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 113/366 (31%), Positives = 175/366 (48%), Gaps = 19/366 (5%) Query 16 LLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHL---VGDDGTYVSAREI 72 LL L GT R+ R ++++ L ++GI+ D + + L + L + G S +I Sbjct 31 LLDGLDGTERSTRIRVLQHLADRGISTDSLASATREGQLGHQLLDVTLSPHGAIYSLEQI 90 Query 73 SENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVR 132 S++ + E ++R R++G V +V + D A + LG+ + R Sbjct 91 SQSTNISPEDVERWFRSMGRG-VSASTSVDYNDDDLRLAQLLNEYRALGIADAGLFAFAR 149 Query 133 VLAEG---LSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ 189 ++ L+ A++++ L+ L A+ Q LL + L Q Sbjct 150 IVGRNTSTLADASKSLIQNNLDTNRDRPEIALQFARELQRFAEFQSQLLHGAVATRLRQQ 209 Query 190 LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLA 249 + + + + + + FAD+VGFT LGE ++ ELG LA RL L Sbjct 210 ISQQIRADITT-------EHTSESHVIAACFADMVGFTVLGEQLTPTELGDLADRLDTLT 262 Query 250 RDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSR 309 DL PPV F+KT+GDAVML+ PDP L VLK+V + P + AG+A G AV Sbjct 263 TDLVEPPVQFVKTVGDAVMLLSPDPTRLAAVVLKIVTAAQQE-GLPPIHAGIAWGTAVRS 321 Query 310 AGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDV 369 AGDW G P+N ASR+ +A P VLV DS EA+ A+ AG +L+G+ G Sbjct 322 AGDWIGQPLNRASRIATIAEPLEVLV-DS--EAMRRIDSAE-ITIESAGTYQLKGLTGGS 377 Query 370 RLFRVR 375 +L+R+R Sbjct 378 QLYRIR 383 >gi|111022051|ref|YP_705023.1| adenylate cyclase [Rhodococcus jostii RHA1] gi|110821581|gb|ABG96865.1| probable adenylate cyclase [Rhodococcus jostii RHA1] Length=351 Score = 121 bits (304), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 101/319 (32%), Positives = 150/319 (48%), Gaps = 25/319 (7%) Query 40 ITPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPD 99 I+P +R L L+G Y A EI++ GV LE R+ ++G A DPD Sbjct 18 ISPTLLRDVQADL---EESLLGGPRRYTRA-EIADFAGVSLERADRLWVSMGFAVDTDPD 73 Query 100 AVVHMRADGEAAARAQRFVELGL-NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIM---- 154 V+ D A V+ G+ +P++ V R L + +S AE I+ Sbjct 74 GVMFTEGDAAALRTIASLVDQGIISPEREVAAARALGQAMSRLAEWQVSLISTHIVDQLA 133 Query 155 -RPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPG- 212 G+ E I + + L ++I+P + + ++ RH+ T N G PG Sbjct 134 GSAGSDEQAIREQVRELTAEILPAVESL---QAYVWRRHIASTTGRNVGN-------PGE 183 Query 213 ---ARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPV-WFIKTIGDAVM 268 +R++ V FAD+VG+T L + A EL L R + + W +KT+GD VM Sbjct 184 EVASRKLVVGFADIVGYTSLTRQLGARELSDLLERFESASTSVIGRHQGWVVKTVGDEVM 243 Query 269 LVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVA 328 PA + L+L E V D P LR G+A G + R GD +GS VN A+R+TG A Sbjct 244 FAVESPADAAEIALQLREQVLPDETDPELRVGLAMGPVLVRFGDLYGSVVNTAARLTGSA 303 Query 329 RPGAVLVADSVREALGDAP 347 RPG VL+ +++ L DAP Sbjct 304 RPGTVLIDEALAHELADAP 322 >gi|226364555|ref|YP_002782337.1| adenylate cyclase [Rhodococcus opacus B4] gi|226243044|dbj|BAH53392.1| adenylate cyclase [Rhodococcus opacus B4] Length=385 Score = 118 bits (295), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 102/328 (32%), Positives = 156/328 (48%), Gaps = 30/328 (9%) Query 37 EQGITPDEIRATNPPLLLATR-----HLVGDDGTYVSAREISENYGVDLELLQRVQRAVG 91 ++ TP EI +P LL + L+G Y A EI++ GV LE R+ ++G Sbjct 44 DEAATPAEI---SPTLLRDVQADLEESLLGGPRRYTRA-EIADVAGVSLERADRLWVSMG 99 Query 92 LARVDDPDAVVHMRADGEAAARAQRFVELGL-NPDQVVLVVRVLAEGLSHAAEAMRYTAL 150 A DPD+V+ D A V+ G+ +P++ V R L + LS AE Sbjct 100 FAVDIDPDSVMFTEGDAAALRTMASLVDRGIISPEREVAAARALGQSLSRLAEWQVSLIS 159 Query 151 EAIM-----RPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERA 205 I+ + E +I + + L ++I+P + + ++ RH+ T N G Sbjct 160 THIVDQLAGSADSDEQEIREQVRGLTAEILPAVESL---QAYVWRRHVASTTGRNVGN-- 214 Query 206 AGKPLPG----ARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPV-WFI 260 PG +R + V FAD+VG+T L + A +L L R + + W + Sbjct 215 -----PGEEVASRNLVVGFADIVGYTSLTRQLGARDLADLLERFESASTTVIGGHQGWVV 269 Query 261 KTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNV 320 KT+GD VM PA + L+L E V D P LR G+A G + R GD +GS VN Sbjct 270 KTVGDEVMFAVESPADAAEIALQLQERVLPDETDPELRVGLAMGPVLVRFGDLYGSVVNT 329 Query 321 ASRVTGVARPGAVLVADSVREALGDAPE 348 A+R+TG ARPG VL+ + + + L +AP+ Sbjct 330 AARLTGSARPGTVLIDEELADELAEAPD 357 >gi|134098563|ref|YP_001104224.1| adenylate cyclase [Saccharopolyspora erythraea NRRL 2338] gi|133911186|emb|CAM01299.1| adenylate cyclase [Saccharopolyspora erythraea NRRL 2338] Length=325 Score = 116 bits (290), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 103/310 (34%), Positives = 153/310 (50%), Gaps = 20/310 (6%) Query 71 EISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELG-LNPDQVVL 129 +++ GV+L +R+ +A+G A VDD DAVV AD A R + V L P+ Sbjct 30 DVAREAGVELRRAERLWQAMGFAHVDD-DAVVFTDADVAALRRLVQLVSAQVLTPEAETA 88 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATEL-DIAKGSQALVSQIVPLLGPMIQDML-F 187 V R L + +S AE I R T L D G A +Q + P+++ + + Sbjct 89 VARSLGQAMSRLAEWQ-----VGIFR---TVLGDDFSGDLATTAQFAGAIMPVMEQLQGY 140 Query 188 MQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAG 247 + RH+ T G R G+ R + + FAD+VG+T+L + EL L Sbjct 141 VWRRHLTATAMRELGGRDTGED---ERTLVIGFADIVGYTRLIRDFTELELASLIDDFEE 197 Query 248 LARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMA 306 LA + A IKT+GD V+ V A + L L E + P LR G+A G+ Sbjct 198 LATGVVAENRGRIIKTVGDEVLFVTDTAADAAEVALSLNEQIAESTRLPPLRIGLAKGVV 257 Query 307 VSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIR 366 ++R GD +GS VN+ASR+T VARP +VLV V +L D P+ + GP +++G R Sbjct 258 LARFGDVYGSTVNIASRLTSVARPASVLVDREVSGSLRDHPD---YHLVSVGPTKVQGFR 314 Query 367 GDVRLFRVRR 376 G +R + +RR Sbjct 315 G-LRAWALRR 323 >gi|291003220|ref|ZP_06561193.1| adenylate cyclase [Saccharopolyspora erythraea NRRL 2338] Length=317 Score = 115 bits (289), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 103/310 (34%), Positives = 153/310 (50%), Gaps = 20/310 (6%) Query 71 EISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELG-LNPDQVVL 129 +++ GV+L +R+ +A+G A VDD DAVV AD A R + V L P+ Sbjct 22 DVAREAGVELRRAERLWQAMGFAHVDD-DAVVFTDADVAALRRLVQLVSAQVLTPEAETA 80 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATEL-DIAKGSQALVSQIVPLLGPMIQDML-F 187 V R L + +S AE I R T L D G A +Q + P+++ + + Sbjct 81 VARSLGQAMSRLAEWQ-----VGIFR---TVLGDDFSGDLATTAQFAGAIMPVMEQLQGY 132 Query 188 MQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAG 247 + RH+ T G R G+ R + + FAD+VG+T+L + EL L Sbjct 133 VWRRHLTATAMRELGGRDTGED---ERTLVIGFADIVGYTRLIRDFTELELASLIDDFEE 189 Query 248 LARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMA 306 LA + A IKT+GD V+ V A + L L E + P LR G+A G+ Sbjct 190 LATGVVAENRGRIIKTVGDEVLFVTDTAADAAEVALSLNEQIAESTRLPPLRIGLAKGVV 249 Query 307 VSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIR 366 ++R GD +GS VN+ASR+T VARP +VLV V +L D P+ + GP +++G R Sbjct 250 LARFGDVYGSTVNIASRLTSVARPASVLVDREVSGSLRDHPD---YHLVSVGPTKVQGFR 306 Query 367 GDVRLFRVRR 376 G +R + +RR Sbjct 307 G-LRAWALRR 315 >gi|300783495|ref|YP_003763786.1| adenylate cyclase [Amycolatopsis mediterranei U32] gi|299793009|gb|ADJ43384.1| adenylate cyclase [Amycolatopsis mediterranei U32] gi|340524881|gb|AEK40086.1| adenylate cyclase [Amycolatopsis mediterranei S699] Length=379 Score = 112 bits (281), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 105/313 (34%), Positives = 148/313 (48%), Gaps = 20/313 (6%) Query 57 RHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQR 116 R L+G Y E++E GV E +R+ RA+G A V D D VV AD EA A + Sbjct 14 RVLLGGRRKYTRL-EVAEKAGVPDERSRRLWRALGFATVRD-DEVVFTDADVEAMRTADQ 71 Query 117 FVELGL-NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRP---GATELDIAKGSQALVS 172 V+ GL +P V V R L + LS AE E I R G +E + + LV Sbjct 72 LVQSGLIDPSIEVSVTRALGQHLSRLAEWQVDMLWELIRRQPELGRSERQVTR----LVD 127 Query 173 QIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEV 232 ++P L +Q+ F+ RH+ +R V F D+VG+T+L Sbjct 128 GLLPEL-ERVQN--FVWRRHLAAYAGRAFAAAGDNVE---SRTEVVGFVDMVGYTRLTRQ 181 Query 233 VSAEELGHLAGRLAGLARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTD 291 + +EL + LA ++ A +K IGD V+ V P + L L E D Sbjct 182 IGEDELSRVLDAFETLATEVIAEHHGRVVKMIGDEVLFVADAPVDAAEIALTLTERTSAD 241 Query 292 NNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADG 351 P +RAG+ASG +SR GD +GS VN+A+R+T VARPG +LV RE G+ E Sbjct 242 ETLPAVRAGMASGRILSRFGDVYGSVVNLAARLTSVARPGTILVD---RELAGELAEEKA 298 Query 352 FQWSFAGPRRLRG 364 ++ P +RG Sbjct 299 YELRTRRPVTVRG 311 >gi|302524847|ref|ZP_07277189.1| adenylate cyclase [Streptomyces sp. AA4] gi|302433742|gb|EFL05558.1| adenylate cyclase [Streptomyces sp. AA4] Length=357 Score = 111 bits (278), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 103/298 (35%), Positives = 142/298 (48%), Gaps = 15/298 (5%) Query 57 RHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQR 116 R L+G Y E++E GV E +R+ RA+G A V+D D VV AD EA A Sbjct 3 RALLGGPRRYTRL-EVAERAGVPEERSRRLWRALGFATVED-DEVVFTDADVEAMRIADG 60 Query 117 FVELGL-NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIV 175 V GL P V V R L + LS AE + E I ++A+ + + + Sbjct 61 LVSSGLIAPGMEVAVTRALGQHLSRLAEWQVHMLWELI----TENPELARSDRQVTRLVE 116 Query 176 PLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPG--ARQVTVAFADLVGFTQLGEVV 233 LL + Q ++ RH+ A AG RA P R + V F D+VG+T+ Sbjct 117 RLLPELEQVQSYVWRRHL----AAFAG-RAFASPDEDLETRALVVGFVDMVGYTRFTREA 171 Query 234 SAEELGHLAGRLAGLARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDN 292 EEL + LA ++ A +K IGD V+ V PA + L L E D Sbjct 172 DEEELTQVLDGFESLATEVIAEHHGRVVKMIGDEVLFVADTPADGAEIALTLAERTGEDG 231 Query 293 NFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEAD 350 + P +RAG+ASG +SR GD +GS VN+A+R+T ARPG VLV + L P+ D Sbjct 232 DLPAVRAGMASGRVLSRFGDVYGSVVNLAARLTSAARPGTVLVDRELAGELESLPQFD 289 >gi|296395295|ref|YP_003660179.1| adenylate/guanylate cyclase [Segniliparus rotundus DSM 44985] gi|296182442|gb|ADG99348.1| adenylate/guanylate cyclase [Segniliparus rotundus DSM 44985] Length=371 Score = 110 bits (276), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 95/290 (33%), Positives = 138/290 (48%), Gaps = 24/290 (8%) Query 58 HLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRF 117 L+G + Y + REI+E GV+ + R+ A G A DP+ + D +A Sbjct 49 RLLGGEHKY-NRREIAELIGVEPYRIARLWVAFGFATDPDPEMKMFTDGDLQALRLFTTL 107 Query 118 VELGL-NPDQVVLVVRVLAEGLSHAAEAMRYTALE-----AIMR-PGATELDIAKGSQ-- 168 V+ GL +PD V R L + + AE TA E A+ R P E D+ S Sbjct 108 VDRGLLDPDMEYTVARNLGQSFARIAEWQAETAYERIRAEAVKRMPEGAEADVVALSGTL 167 Query 169 --ALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGF 226 AL+ +++P +Q L+ RH+ A NA +R G+ G + V FAD+VG+ Sbjct 168 AGALLDEVLPAFD-FVQSYLWR--RHL----AANA-QRVGGQ---GEHKFAVGFADMVGY 216 Query 227 TQLGEVVSAEELGHLAGRLAGLARD-LTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLV 285 T+L + EL L A +T W +KT+GD VM P L L+ Sbjct 217 TRLTRSLDEPELDRLLESFESTATTVITQEGGWLVKTLGDEVMFASASPQAAARIALTLL 276 Query 286 EVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLV 335 + V P LR GVA G ++R GD +G VN+ASR+T A+PG+VL+ Sbjct 277 DFVPDGEEVPELRVGVAYGRVLTRFGDLYGPTVNIASRLTTSAKPGSVLI 326 >gi|226308544|ref|YP_002768504.1| adenylate cyclase [Rhodococcus erythropolis PR4] gi|226187661|dbj|BAH35765.1| putative adenylate cyclase [Rhodococcus erythropolis PR4] Length=381 Score = 110 bits (275), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 93/307 (31%), Positives = 146/307 (48%), Gaps = 26/307 (8%) Query 71 EISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELG-LNPDQVVL 129 +I++ GV E R+ A+G A +DPDAV+ + D +A V G ++ + V Sbjct 75 QIADFAGVTRERADRLWVAMGFAVDEDPDAVMFTQQDADALKTITDMVNRGVISQNSEVA 134 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATELD-----IAKGSQALVSQIVPLLGPMIQD 184 R L + +S AE I+ A +D I +L ++I+P + + Sbjct 135 AARSLGQSMSRLAEWQVSLISTHIIDQLADSVDHEPDAIRNVVLSLGAEIIPAVESL--- 191 Query 185 MLFMQLRHMMETEAVNAGERAAGKPLPG----ARQVTVAFADLVGFTQLGEVVSAEELGH 240 ++ RH+ + N G PG +R + V FAD+VG+T L + + EL Sbjct 192 QTYVWKRHVASSTGRNVGN-------PGEEVASRVLVVGFADIVGYTSLTRGLDSAELND 244 Query 241 LAGRLAGLARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRA 299 L R + ++ W +KT+GD VM P + L++ + V D++ P+LR Sbjct 245 LLERFESASTEIIGRNYGWVVKTVGDEVMFAAESPHHAAEIALQIQQAVLADHDDPQLRV 304 Query 300 GVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALG-DAPEADGFQWSFAG 358 G+A G + R GD +GS VN A+R+T ARPG VL+ + LG DA F+ Sbjct 305 GLAMGPTLVRFGDLYGSVVNKAARLTSSARPGTVLIDSELATQLGSDA----NFKLRHLR 360 Query 359 PRRLRGI 365 PRR+RGI Sbjct 361 PRRVRGI 367 >gi|257056835|ref|YP_003134667.1| family 3 adenylate cyclase [Saccharomonospora viridis DSM 43017] gi|256586707|gb|ACU97840.1| family 3 adenylate cyclase [Saccharomonospora viridis DSM 43017] Length=346 Score = 110 bits (275), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 93/279 (34%), Positives = 137/279 (50%), Gaps = 10/279 (3%) Query 71 EISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGL-NPDQVVL 129 E++ GV E +++ RA+G A V D D VV AD EA A R V GL + D Sbjct 26 EVAAKSGVSPERARQLWRALGFASVGD-DEVVFTDADVEAVRIADRLVGEGLLDRDLETS 84 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQ 189 V R + +S AE + L +++ + + LV +++P LG + F Sbjct 85 VARAVGLHMSRLAE-WQSQLLRSLIADNPHLAERPEQLAELVERLLPQLGRLHD---FAW 140 Query 190 LRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLA 249 RH++ A + AA +R V F D+VG+T++ EL + R LA Sbjct 141 RRHLV---AYSGRALAASHEQLESRHQVVGFVDMVGYTRMVRRFDEAELSAVLERFESLA 197 Query 250 RDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVS 308 ++ +K IGD V+ VC P + L L E D P +RAG+ASG +S Sbjct 198 TEVVVEHHGRVVKLIGDEVLFVCSQPVEAAEIALTLTEQAGADERLPEVRAGLASGRVLS 257 Query 309 RAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAP 347 R GD +GS VN+ASR+T +ARPG VLV ++ +AL + P Sbjct 258 RFGDVYGSVVNLASRLTELARPGTVLVNATLADALAEEP 296 >gi|229488641|ref|ZP_04382507.1| adenylate cyclase [Rhodococcus erythropolis SK121] gi|229324145|gb|EEN89900.1| adenylate cyclase [Rhodococcus erythropolis SK121] Length=381 Score = 109 bits (273), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 96/307 (32%), Positives = 144/307 (47%), Gaps = 26/307 (8%) Query 71 EISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELG-LNPDQVVL 129 +I+E GV E R+ A+G A +DPDAV+ + D A V G ++ V Sbjct 75 QIAEFAGVTRERADRLWVAMGFAVDEDPDAVMFTQQDANALKTIIDMVNRGVISQSSEVA 134 Query 130 VVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLG----PMIQDM 185 R L + +S AE I+ A D A + +IV LG P ++ + Sbjct 135 AARSLGQSMSRLAEWQVSLISTHIIDQLA---DSADHEPEAIRKIVLRLGAEIIPAVESL 191 Query 186 -LFMQLRHMMETEAVNAGERAAGKPLPG----ARQVTVAFADLVGFTQLGEVVSAEELGH 240 ++ RH+ + N G PG +R + V FAD+VG+T L + + EL Sbjct 192 QTYVWKRHVASSTGRNVGN-------PGEEVASRVLVVGFADIVGYTSLTRGLDSAELND 244 Query 241 LAGRLAGLARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRA 299 L R + ++ W +KT+GD VM P + L++ + V D++ P+LR Sbjct 245 LLERFESASTEIIGRNYGWVVKTVGDEVMFAAESPHHAAEIALQIQQAVLADHDDPQLRV 304 Query 300 GVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALG-DAPEADGFQWSFAG 358 G+A G + R GD +GS VN A+R+T ARPG VL+ + LG DA F+ Sbjct 305 GLAMGPTLVRFGDLYGSVVNKAARLTSSARPGTVLIDSELATQLGSDA----NFKLRHLR 360 Query 359 PRRLRGI 365 PRR+RGI Sbjct 361 PRRVRGI 367 >gi|326333791|ref|ZP_08200024.1| adenylate cyclase [Nocardioidaceae bacterium Broad-1] gi|325948373|gb|EGD40480.1| adenylate cyclase [Nocardioidaceae bacterium Broad-1] Length=316 Score = 109 bits (272), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 96/314 (31%), Positives = 148/314 (48%), Gaps = 12/314 (3%) Query 67 VSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGL-NPD 125 +++ E++E GV L+ +R+ RA+G + D +A AD A ++A GL + D Sbjct 10 LTSAEVAEKAGVSLDQAKRLWRALGFPEIGDTEAFFD-EADVHALSKANEIAGNGLVSFD 68 Query 126 QVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDM 185 VV + R + + ++ ++ L + E ++ +A VS + M Sbjct 69 LVVNLTRGIGQSMARLSDYEVSALLHHVETQNEDERSPSELLKATVSVSEQFESAFEEMM 128 Query 186 LFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRL 245 +F RHM A A + G TV FAD+V FT L ++ E++G L Sbjct 129 IFAWRRHMRAALARAEASIAGPEEQLGTVWQTVGFADIVSFTALSNTLTEEKIGDLVELF 188 Query 246 AGLARDLTAPPVW---FIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVA 302 D+ A W IK++GD+V+ V DP T ++ V+ D P +R G+A Sbjct 189 ESRCADVVA--TWGGRIIKSLGDSVLFVNDDPLQAYGTAEGIINVIGRDPRMPDVRVGLA 246 Query 303 SGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRL 362 SG VSR GD FG PVN+A+R+T VAR ++V ++ G PE D F+ R + Sbjct 247 SGNVVSRLGDVFGPPVNMAARLTAVARRNRIIVDEAT---AGTMPE-DEFETRRLAARPV 302 Query 363 RGIRGDVRLFRVRR 376 RG G V VRR Sbjct 303 RGF-GIVEPVAVRR 315 >gi|291453042|ref|ZP_06592432.1| adenylate cyclase [Streptomyces albus J1074] gi|291355991|gb|EFE82893.1| adenylate cyclase [Streptomyces albus J1074] Length=348 Score = 108 bits (271), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 97/289 (34%), Positives = 135/289 (47%), Gaps = 13/289 (4%) Query 55 ATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARA 114 A L+ G + +EI+E GV E +++ RA+G A VDD DA V AD EA Sbjct 23 AVEELLLGGGRAYTRQEIAERAGVGPERTRQIWRALGFAAVDD-DARVFTDADAEALRAG 81 Query 115 QRFVELGL-NPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQ 173 +R + GL + ++ R L LS AE + R A +D A AL+ Sbjct 82 ERLIAAGLITEESETMMARALGHHLSRLAEWQIHALWTWAGRDPARPVDGA----ALLEH 137 Query 174 IVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQV------TVAFADLVGFT 227 LL M + RH+ AA ARQ V F D+VG+T Sbjct 138 AAVLLPEMELLQRHVWRRHLAAYAGRALAGAAAPGGHAEARQSGDVRERAVGFTDMVGYT 197 Query 228 QLGEVVSAEELGHLAGRLAGLARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVE 286 ++ + + LG + R L D+ A +KTIGD V+ VC A D L+L Sbjct 198 RMTRGLDSTALGRVLDRFETLTGDVVAEGRGRVVKTIGDEVLYVCESAASAADIALELTA 257 Query 287 VVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLV 335 + + + PRLR G+A G +SR GD +GS VN+A+R+T VARP VLV Sbjct 258 RAEAEPDLPRLRTGLAHGPVLSRFGDVYGSAVNIAARLTAVARPETVLV 306 >gi|119855124|ref|YP_935729.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] gi|119697842|gb|ABL94914.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] Length=216 Score = 107 bits (267), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 65/159 (41%), Positives = 86/159 (55%), Gaps = 4/159 (2%) Query 217 TVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAP 276 T AF DL GFT L E+ E+ HLAGRL L RD A V +K +GDAVML DP Sbjct 10 TFAFVDLSGFTALTEICGDEQAAHLAGRLVELTRDSLALDVTLVKAMGDAVMLHAHDPDT 69 Query 277 LLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVA 336 ++ T+L L + ++ F LRAG+ G AV R D+FG VN A+RVT +A G ++ Sbjct 70 MMATILDLADRAADEDGFLGLRAGIHHGSAVQRHHDYFGDAVNTAARVTALAGAGHAVIT 129 Query 337 DSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVR 375 + + A EA G G LR I V ++RV+ Sbjct 130 EPILTAC----EARGVAAHPLGETELRNISAPVAVYRVQ 164 >gi|311743182|ref|ZP_07716990.1| adenylate cyclase [Aeromicrobium marinum DSM 15272] gi|311313862|gb|EFQ83771.1| adenylate cyclase [Aeromicrobium marinum DSM 15272] Length=329 Score = 105 bits (262), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 101/317 (32%), Positives = 147/317 (47%), Gaps = 28/317 (8%) Query 59 LVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFV 118 L+ D+ Y +A +++E GV E QR+ RA+G DP V A G+A RA R V Sbjct 14 LLQDELRYTTA-QVAERGGVGPEQAQRLWRALGFP---DPGETV---AFGDADVRAIRSV 66 Query 119 ELG-----LNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQA---- 169 + G L D V + R L + ++ A+ T ++ + R D+ G Sbjct 67 QAGIEQGVLEDDTTVRLTRALGQTMAKLADWEVSTLIDQLER------DVGAGRAGSRLE 120 Query 170 LVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQL 229 + + P+ ++++ R + A A + Q+TV FADL FT L Sbjct 121 RATWLAQHAAPVFEELMLHVWRRHLAAAAARLEALGAADEELLSMQMTVGFADLSRFTSL 180 Query 230 GEVVSAEELGHLAGRLAGLARDL-TAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVV 288 + +L L R DL TA IKT+GDA++ V PDP T L LV V Sbjct 181 SNSLDDNDLAALVERFEERCADLITAQGGRVIKTLGDAILYVSPDPCGATRTALDLVAQV 240 Query 289 DTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPE 348 + ++ P +R G+A+G +SR GD FG PVN+A+R++ VAR VLV D LG Sbjct 241 GSRDDLPAIRVGLATGSVISRLGDVFGPPVNLAARLSHVARSNRVLVDDDTAATLGQE-- 298 Query 349 ADGFQWSFAGPRRLRGI 365 F+ PR LRG Sbjct 299 ---FEQRALPPRPLRGF 312 >gi|317509276|ref|ZP_07966897.1| adenylate and Guanylate cyclase catalytic domain-containing protein [Segniliparus rugosus ATCC BAA-974] gi|316252486|gb|EFV11935.1| adenylate and Guanylate cyclase catalytic domain-containing protein [Segniliparus rugosus ATCC BAA-974] Length=359 Score = 105 bits (261), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 100/325 (31%), Positives = 150/325 (47%), Gaps = 33/325 (10%) Query 58 HLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRF 117 L+G + Y + REI+E GV + R+ A G A DPD V M DG+ A + F Sbjct 36 RLLGGERKY-NRREIAELIGVQPYRIARLWVAFGFA--TDPDPEVKMFTDGDLQA-LRLF 91 Query 118 VELG----LNPDQVVLVVRVLAEGLSHAAEAMRYTALEAI-------MRPGATELDI--- 163 L L P+ V R L + + AE T + I + GA E ++ Sbjct 92 TTLVDRDLLAPEMEYTVARNLGQSFARIAEWQAETTYDRIRAAALARLPEGADEAEVVTL 151 Query 164 -AKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFAD 222 K + L+ +++P +Q L+ RH+ A NA +R G+ ++ V FAD Sbjct 152 SGKLAGTLLDEVLPAFD-FVQSYLWR--RHL----AANA-QRVGGQT---EHKLAVGFAD 200 Query 223 LVGFTQLGEVVSAEELGHLAGRLAGLARD-LTAPPVWFIKTIGDAVMLVCPDPAPLLDTV 281 +VG+T+L + ELG L A +T W +KT+GD +M P Sbjct 201 MVGYTRLTRSLDERELGRLLESFESTATTVITQEGGWVVKTLGDEIMFAAASPQSAARIA 260 Query 282 LKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVRE 341 L+L + V + P+LR GVA G ++R GD +G VN+ASR+T A+PG VL+ + E Sbjct 261 LELQDFVPDGEDVPQLRVGVAYGKVLTRFGDLYGPTVNIASRLTTSAKPGGVLIDGELAE 320 Query 342 ALGDAPEADGFQWSFAGPRRLRGIR 366 + E D P ++RG R Sbjct 321 EI--VEEHDMHIKPLRRPLQVRGYR 343 >gi|296268690|ref|YP_003651322.1| adenylate/guanylate cyclase [Thermobispora bispora DSM 43833] gi|296091477|gb|ADG87429.1| adenylate/guanylate cyclase [Thermobispora bispora DSM 43833] Length=337 Score = 101 bits (251), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 100/327 (31%), Positives = 146/327 (45%), Gaps = 19/327 (5%) Query 57 RHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQR 116 R LV + R++ E GV + R+ RA+G D DAV AD A R + Sbjct 13 RWLVAGSQPVYTRRQVIEAAGVRPDFASRIWRALGFPAPAD-DAVAFSEADVAALRRVRA 71 Query 117 FVELGLNPDQVVLVV-----RVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALV 171 +E GL +Q + + R A AE M + LE RPG +L+ V Sbjct 72 HLEAGLLDEQTTIRMARALGRTTARLAQWQAEIMTSSLLEQPGRPGEADLE-------RV 124 Query 172 SQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPL-PGARQVTVAFADLVGFTQLG 230 + L P + ML R + A G+ PG + V FADLV FT++ Sbjct 125 METTRRLLPDFEQMLVHVWRSQLSVATSRLLSLAEGEEAQPGRPCLAVGFADLVAFTKVS 184 Query 231 EVVSAEELGHLAGRLAGLARDLTAPPV-WFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVD 289 + L L R A D+ A +KT+GD V+ +P+ + L LV + Sbjct 185 RELDEPALAELVERFESRASDVIAAHGGRLVKTLGDEVLFTSDEPSGVASIALDLVSELK 244 Query 290 TDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEA 349 D + P +R G+A G V GD FG+ VN+A+R+T +ARPG + +AD+ E G Sbjct 245 RDKSGPDVRIGLAYGPVVPLMGDVFGATVNLAARLTSIARPGTI-IADA--ELAGALNGV 301 Query 350 DGFQWSFAGPRRLRGIRGDVRLFRVRR 376 GF R +RG+ G +R + +RR Sbjct 302 AGFHLVRLRARPVRGV-GTIRPYVLRR 327 Lambda K H 0.319 0.136 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 779602889160 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40