BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1318c Length=541 Score E Sequences producing significant alignments: (Bits) Value gi|15608458|ref|NP_215834.1| adenylate cyclase [Mycobacterium tu... 1071 0.0 gi|339631385|ref|YP_004723027.1| adenylate cyclase [Mycobacteriu... 1070 0.0 gi|148822536|ref|YP_001287290.1| adenylate cyclase [Mycobacteriu... 1070 0.0 gi|340626333|ref|YP_004744785.1| putative adenylate cyclase [Myc... 1070 0.0 gi|289442759|ref|ZP_06432503.1| adenylate cyclase [Mycobacterium... 1003 0.0 gi|240169497|ref|ZP_04748156.1| adenylate cyclase [Mycobacterium... 840 0.0 gi|183984049|ref|YP_001852340.1| adenylate cyclase [Mycobacteriu... 812 0.0 gi|296170261|ref|ZP_06851852.1| adenylate cyclase [Mycobacterium... 807 0.0 gi|118465998|ref|YP_880776.1| HAMP domain-containing protein [My... 795 0.0 gi|41408538|ref|NP_961374.1| hypothetical protein MAP2440 [Mycob... 793 0.0 gi|342858019|ref|ZP_08714675.1| hypothetical protein MCOL_04055 ... 785 0.0 gi|254821322|ref|ZP_05226323.1| hypothetical protein MintA_15392... 774 0.0 gi|183984050|ref|YP_001852341.1| adenylate cyclase [Mycobacteriu... 736 0.0 gi|253799635|ref|YP_003032636.1| adenylate cyclase [Mycobacteriu... 736 0.0 gi|15608459|ref|NP_215835.1| adenylate cyclase [Mycobacterium tu... 733 0.0 gi|148822541|ref|YP_001287295.1| adenylate cyclase [Mycobacteriu... 732 0.0 gi|254364216|ref|ZP_04980262.1| hypothetical adenylate cyclase (... 731 0.0 gi|339631387|ref|YP_004723029.1| adenylate cyclase [Mycobacteriu... 730 0.0 gi|298524824|ref|ZP_07012233.1| adenylate cyclase [Mycobacterium... 730 0.0 gi|15840772|ref|NP_335809.1| adenylate cyclase, putative [Mycoba... 729 0.0 gi|289745069|ref|ZP_06504447.1| adenylate cyclase [Mycobacterium... 727 0.0 gi|15840771|ref|NP_335808.1| adenylate cyclase, putative [Mycoba... 727 0.0 gi|326902942|gb|EGE49875.1| LOW QUALITY PROTEIN: adenylate cycla... 726 0.0 gi|340626334|ref|YP_004744786.1| adenylate cyclase [Mycobacteriu... 724 0.0 gi|289446915|ref|ZP_06436659.1| adenylate cyclase, putative [Myc... 723 0.0 gi|183984051|ref|YP_001852342.1| adenylate cyclase [Mycobacteriu... 723 0.0 gi|289446916|ref|ZP_06436660.1| adenylate cyclase [Mycobacterium... 722 0.0 gi|340626336|ref|YP_004744788.1| putative adenylate cyclase [Myc... 721 0.0 gi|120405263|ref|YP_955092.1| putative adenylate/guanylate cycla... 720 0.0 gi|15840773|ref|NP_335810.1| adenylate cyclase, putative [Mycoba... 720 0.0 gi|289757423|ref|ZP_06516801.1| adenylate cyclase [Mycobacterium... 719 0.0 gi|298524825|ref|ZP_07012234.1| conserved hypothetical protein [... 719 0.0 gi|15608460|ref|NP_215836.1| adenylate cyclase [Mycobacterium tu... 718 0.0 gi|339631388|ref|YP_004723030.1| adenylate cyclase [Mycobacteriu... 717 0.0 gi|118619151|ref|YP_907483.1| adenylate cyclase [Mycobacterium u... 714 0.0 gi|240169496|ref|ZP_04748155.1| putative adenylate cyclase [Myco... 709 0.0 gi|333989962|ref|YP_004522576.1| adenylate cyclase [Mycobacteriu... 709 0.0 gi|145222924|ref|YP_001133602.1| putative adenylate/guanylate cy... 703 0.0 gi|108800832|ref|YP_641029.1| adenylate/guanylate cyclase [Mycob... 701 0.0 gi|118473953|ref|YP_889179.1| adenylate cyclase, family protein ... 692 0.0 gi|183984091|ref|YP_001852382.1| adenylate cyclase [Mycobacteriu... 685 0.0 gi|289573983|ref|ZP_06454210.1| conserved hypothetical protein [... 683 0.0 gi|118619189|ref|YP_907521.1| adenylate cyclase [Mycobacterium u... 682 0.0 gi|339294302|gb|AEJ46413.1| adenylate cyclase, putative [Mycobac... 670 0.0 gi|308399382|ref|ZP_07492998.2| adenylate cyclase [Mycobacterium... 668 0.0 gi|183983769|ref|YP_001852060.1| adenylate cyclase [Mycobacteriu... 644 0.0 gi|289761474|ref|ZP_06520852.1| adenylate cyclase [Mycobacterium... 615 6e-174 gi|306792738|ref|ZP_07431040.1| putative HAMP domain protein [My... 606 3e-171 gi|306784048|ref|ZP_07422370.1| adenylate cyclase [Mycobacterium... 600 1e-169 gi|306784046|ref|ZP_07422368.1| putative HAMP domain protein [My... 597 2e-168 >gi|15608458|ref|NP_215834.1| adenylate cyclase [Mycobacterium tuberculosis H37Rv] gi|15840770|ref|NP_335807.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|31792513|ref|NP_855006.1| adenylate cyclase [Mycobacterium bovis AF2122/97] 60 more sequence titles Length=541 Score = 1071 bits (2771), Expect = 0.0, Method: Compositional matrix adjust. Identities = 541/541 (100%), Positives = 541/541 (100%), Gaps = 0/541 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG Sbjct 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 Query 541 R 541 R Sbjct 541 R 541 >gi|339631385|ref|YP_004723027.1| adenylate cyclase [Mycobacterium africanum GM041182] gi|339330741|emb|CCC26412.1| putative adenylate cyclase (ATP pyrophosphate-lyase) [Mycobacterium africanum GM041182] Length=541 Score = 1070 bits (2767), Expect = 0.0, Method: Compositional matrix adjust. Identities = 540/541 (99%), Positives = 540/541 (99%), Gaps = 0/541 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIEGRKP REEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG Sbjct 121 AIEGRKPAREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 Query 541 R 541 R Sbjct 541 R 541 >gi|148822536|ref|YP_001287290.1| adenylate cyclase [Mycobacterium tuberculosis F11] gi|253799636|ref|YP_003032637.1| adenylate cyclase [Mycobacterium tuberculosis KZN 1435] gi|254550326|ref|ZP_05140773.1| adenylate cyclase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] 11 more sequence titles Length=541 Score = 1070 bits (2767), Expect = 0.0, Method: Compositional matrix adjust. Identities = 540/541 (99%), Positives = 540/541 (99%), Gaps = 0/541 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG Sbjct 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FEMVLLNLTRMQFATGVLIISMVTLV GFILMWILAWLTATPVRVVRAALRRVERGELRT Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVLGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 Query 541 R 541 R Sbjct 541 R 541 >gi|340626333|ref|YP_004744785.1| putative adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|340004523|emb|CCC43666.1| putative adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium canettii CIPT 140010059] Length=541 Score = 1070 bits (2766), Expect = 0.0, Method: Compositional matrix adjust. Identities = 539/541 (99%), Positives = 541/541 (100%), Gaps = 0/541 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALA+GSYALTRQTVQALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALAVGSYALTRQTVQALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIEGRKPTRE+ERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG Sbjct 121 AIEGRKPTREDERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 Query 541 R 541 R Sbjct 541 R 541 >gi|289442759|ref|ZP_06432503.1| adenylate cyclase [Mycobacterium tuberculosis T46] gi|289415678|gb|EFD12918.1| adenylate cyclase [Mycobacterium tuberculosis T46] Length=540 Score = 1003 bits (2594), Expect = 0.0, Method: Compositional matrix adjust. Identities = 532/546 (98%), Positives = 533/546 (98%), Gaps = 11/546 (2%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC- 179 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFI + C Sbjct 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFI------IDRCS 174 Query 180 ----GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGI 235 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGI Sbjct 175 QQRGGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGI 234 Query 236 ALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVER 295 ALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVER Sbjct 235 ALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVER 294 Query 296 GELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGG 355 GELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGG Sbjct 295 GELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGG 354 Query 356 EERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTI 415 EERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTI Sbjct 355 EERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTI 414 Query 416 FGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIG 475 FGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIG Sbjct 415 FGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIG 474 Query 476 EPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVG 535 EPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVG Sbjct 475 EPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVG 534 Query 536 LTKPRR 541 LTKPRR Sbjct 535 LTKPRR 540 >gi|240169497|ref|ZP_04748156.1| adenylate cyclase [Mycobacterium kansasii ATCC 12478] Length=541 Score = 840 bits (2169), Expect = 0.0, Method: Compositional matrix adjust. Identities = 423/541 (79%), Positives = 479/541 (89%), Gaps = 0/541 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M A++S AQRLGRVLETVTRQSGRL ETPAYGSWLLGRVSE QRRRR+RIQV+LT +VV Sbjct 1 MVAEESMAQRLGRVLETVTRQSGRLSETPAYGSWLLGRVSEDQRRRRIRIQVILTVMVVA 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 AN++GI V++LLVT+AIPEPS+ D P W++F VVP Y+++ALALG+Y +TR+TV ALRW Sbjct 61 ANVIGIAVSILLVTVAIPEPSVFSDAPLWVSFAVVPAYIVVALALGAYWITRRTVIALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R PT ++ER TFL PWRVA+ L+ WGVG ALLTTLYG+ N FIPRFLFAVSFCG Sbjct 121 AIEERPPTHDDERNTFLTPWRVAIVDLILWGVGAALLTTLYGMANTMFIPRFLFAVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 +LVAT +YL TEFALRP AAQALEAGPPPRRLA GI+GRTM+VWLLGSGVP+VGIAL+A+ Sbjct 181 LLVATGSYLLTEFALRPVAAQALEAGPPPRRLASGIMGRTMMVWLLGSGVPIVGIALIAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F++ + NLT QFA GVLI+SM TLVFGF+LMWILAWLTATPVRVVRAAL+RVERG+LR Sbjct 241 FQIGMRNLTATQFAVGVLIVSMATLVFGFVLMWILAWLTATPVRVVRAALQRVERGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVA AAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVHGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DIVGST+LVTS+PPA+VV+LLN+FFAIVV+EVDRH+GLVNKFEGDASL IFGAPN Sbjct 361 AVVFLDIVGSTKLVTSQPPAEVVQLLNRFFAIVVEEVDRHYGLVNKFEGDASLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L PED+ALA AR +A RL EM ECQAGIGVA+GQV+AGNVG++ERFEYTVIGEPVNE Sbjct 421 HLDQPEDQALACARTLAQRLAEEMRECQAGIGVASGQVVAGNVGSKERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPR 540 AARLCE AKSRPGKLLASAQ V+AASE ERA W+LGRHVKLRGH QP RLA P+ PR Sbjct 481 AARLCERAKSRPGKLLASAQTVEAASESERAHWTLGRHVKLRGHKQPTRLASPIEPATPR 540 Query 541 R 541 R Sbjct 541 R 541 >gi|183984049|ref|YP_001852340.1| adenylate cyclase [Mycobacterium marinum M] gi|183177375|gb|ACC42485.1| adenylate cyclase [Mycobacterium marinum M] Length=550 Score = 812 bits (2098), Expect = 0.0, Method: Compositional matrix adjust. Identities = 410/527 (78%), Positives = 462/527 (88%), Gaps = 0/527 (0%) Query 8 AQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIG 67 AQRLGRVLE VTRQSGRLPETPAYGSWLLGRVSESQ+RRR+RIQ +LT +VV ANLLGI Sbjct 24 AQRLGRVLERVTRQSGRLPETPAYGSWLLGRVSESQQRRRIRIQTILTVMVVVANLLGIA 83 Query 68 VALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKP 127 V++LLVT+AIP PS+ + P W+TF VVP Y+++ALALG+Y +TR+TV ALRWAIE R+P Sbjct 84 VSILLVTVAIPSPSVFTEAPWWITFVVVPSYIVVALALGTYWITRRTVLALRWAIEERQP 143 Query 128 TREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATAT 187 T E+ER TFLA WRVAV L+ WG G LLTTLYG+ N FIPRFLFAV+FCGVLVAT + Sbjct 144 TPEDERNTFLAAWRVAVVDLILWGSGAVLLTTLYGMANTMFIPRFLFAVTFCGVLVATGS 203 Query 188 YLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLN 247 YL TEFALRP AAQAL AGPPPRRL+ GI+GRTM+VWLLGSGVPVVGIAL+A+F++ L N Sbjct 204 YLLTEFALRPVAAQALAAGPPPRRLSSGIMGRTMMVWLLGSGVPVVGIALVAIFQIALRN 263 Query 248 LTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDG 307 L+ QFA GVLI+SM TL+FGFILMWI++WLTATPVRVVRAAL RV G+LR +LVVFDG Sbjct 264 LSETQFAVGVLIVSMATLIFGFILMWIMSWLTATPVRVVRAALNRVANGDLRGDLVVFDG 323 Query 308 TELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDI 367 TELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAERER KLGGEERHVAVVFIDI Sbjct 324 TELGELQRGFNTMVDGLRERERVRDLFGRHVGREVAIAAERERPKLGGEERHVAVVFIDI 383 Query 368 VGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPED 427 VGST+LVTS+PPADVV LLN+FFA+VVDEVDRH GLVNKFEGDASL IFGAPN L PED Sbjct 384 VGSTKLVTSQPPADVVALLNRFFAVVVDEVDRHRGLVNKFEGDASLAIFGAPNHLERPED 443 Query 428 KALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCEL 487 +ALAAAR IA RL +E+PECQAGIGVAAGQV+AGNVG++ERFEYTVIGEPVNEAARLCEL Sbjct 444 QALAAARTIAARLASEVPECQAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNEAARLCEL 503 Query 488 AKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AK PG+LLAS A+D AS +ERARWS+G+ V LRGHDQP RLA P+ Sbjct 504 AKDHPGRLLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLAAPI 550 >gi|296170261|ref|ZP_06851852.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894984|gb|EFG74703.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=544 Score = 807 bits (2084), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/533 (76%), Positives = 462/533 (87%), Gaps = 0/533 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSA +S A+R+GRVLETVTRQSGRLPETPAYGS LLGRV+ESQ+RRR+RIQV+LT LV+ Sbjct 1 MSANQSLAKRIGRVLETVTRQSGRLPETPAYGSLLLGRVTESQQRRRIRIQVILTVLVLG 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANL+GI VALLLVT+AIP+PS+ D P W+TF P Y+ LALA+G+Y +TR+TV ALRW Sbjct 61 ANLIGIVVALLLVTVAIPQPSVFDDAPWWITFAASPAYIALALAVGTYWITRRTVLALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R PT E+ER TFLAPWR+A L+ WGVG +LTTLYGL+N FIPRFL AV CG Sbjct 121 AIEERAPTEEDERNTFLAPWRIARFDLILWGVGAVVLTTLYGLVNTLFIPRFLIAVGICG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 +LVAT +YL EFALRP AAQALEAGPPPRR A GI+GRTMVVW LGSG+PV+GIA +A Sbjct 181 ILVATGSYLLAEFALRPAAAQALEAGPPPRRFASGIMGRTMVVWFLGSGLPVLGIAFLAG 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F+ ++ NLT QFA GVL++S+ T+ FG +LMWILAWLTATPVRVVRAALRRVERG+LR Sbjct 241 FQALMRNLTETQFAVGVLMVSIATVTFGCLLMWILAWLTATPVRVVRAALRRVERGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVA AAERE+ KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAEREKPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGST+LVTSRP A++V+LLN+FFAIVV+EVDRH GLVNKFEGDA+L +FGAPN Sbjct 361 AVVFIDIVGSTKLVTSRPAAEIVQLLNRFFAIVVEEVDRHCGLVNKFEGDATLAVFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PE++ALAAAR+IA RL +E+ ECQAGIGVAAGQV+AGNVGARERFEYTVIG PVNE Sbjct 421 RLDRPEEQALAAARSIAGRLDSEIAECQAGIGVAAGQVVAGNVGARERFEYTVIGGPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 A+RLCELAKS PG+LLA+A A++ AS+ ERARWSLG V LRGH++P RLA P Sbjct 481 ASRLCELAKSHPGRLLATADALEGASDTERARWSLGDTVTLRGHERPTRLASP 533 >gi|118465998|ref|YP_880776.1| HAMP domain-containing protein [Mycobacterium avium 104] gi|254774360|ref|ZP_05215876.1| HAMP domain-containing protein [Mycobacterium avium subsp. avium ATCC 25291] gi|118167285|gb|ABK68182.1| hamp domain protein [Mycobacterium avium 104] Length=544 Score = 795 bits (2054), Expect = 0.0, Method: Compositional matrix adjust. Identities = 409/535 (77%), Positives = 461/535 (87%), Gaps = 0/535 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSA +STAQR+GRVLE +TRQSGRLPETPAYGS LLGRV+ESQ RRR+RIQ+++T +V+ Sbjct 1 MSATQSTAQRIGRVLEKITRQSGRLPETPAYGSLLLGRVTESQHRRRIRIQIIMTVMVLG 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANL+GIG AL+LV +AIP PS+ D P W+TFGV P YV ALA+G+Y +TR+TV ALRW Sbjct 61 ANLIGIGAALILVIVAIPAPSVFNDAPAWITFGVGPAYVASALAVGTYWITRRTVLALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE RKPT +ER TFLAPWR+A+ L+ WG GT LLT LYGL++ FIPRFLF VSFCG Sbjct 121 AIEERKPTPTDERNTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVATA YL EFALRP AAQALEAGPPPRRL GI+GRTM VW LGSGVPV+GIAL+A+ Sbjct 181 VLVATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVIGIALLAL 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FE+ L NLT +FA GVLI+S L+FG +LMWILAWLTATPVRVVRAAL+RVERG+LR Sbjct 241 FEIWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVA AAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVT RPPA+VV +LN+FF IVV+EVDRH GLVNKFEGDA+L IFGAPN Sbjct 361 AVVFIDIVGSTQLVTRRPPAEVVSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L CPED AL AARAIADRL NEMP+C+AGIGVAAGQV+AGNVGARERFEYTVIGEPVNE Sbjct 421 HLDCPEDAALTAARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVG 535 AARLCELAKS G+LLA+ A++ ASE+ERARWSLG V LRGH++P RLA P G Sbjct 481 AARLCELAKSHSGRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLASPAG 535 >gi|41408538|ref|NP_961374.1| hypothetical protein MAP2440 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396896|gb|AAS04757.1| hypothetical protein MAP_2440 [Mycobacterium avium subsp. paratuberculosis K-10] gi|336460972|gb|EGO39853.1| family 3 adenylate cyclase [Mycobacterium avium subsp. paratuberculosis S397] Length=544 Score = 793 bits (2049), Expect = 0.0, Method: Compositional matrix adjust. Identities = 408/535 (77%), Positives = 460/535 (86%), Gaps = 0/535 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MSA +STAQR+GRVLE +TRQSGRLPETPAYGS LLGRV+ESQ RRR+RIQ+++T +V+ Sbjct 1 MSATQSTAQRIGRVLEKITRQSGRLPETPAYGSLLLGRVTESQHRRRIRIQIIMTVMVLG 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANL+GIG AL+LV +AIP PS+ D P W+TFGV P YV ALA+G+Y +TR+TV ALRW Sbjct 61 ANLIGIGAALILVIVAIPAPSVFNDAPAWITFGVGPAYVASALAVGTYWITRRTVLALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE RKPT +ER TFLAPWR+A+ L+ WG GT LLT LYGL++ FIPRFLF VSFCG Sbjct 121 AIEERKPTPTDERNTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVATA YL EFALRP AAQALEAGPPPRRL GI+GRTM VW LGSGVPV+GIAL+A+ Sbjct 181 VLVATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVIGIALLAL 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FE+ L NLT +FA GVLI+S L+FG +LMWILAWLTATPVRVVRAAL+RVERG+LR Sbjct 241 FEIWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVA AAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVT RPPA+VV +LN+FF IVV+EVDRH GLVNKFEGDA+L IFGAPN Sbjct 361 AVVFIDIVGSTQLVTRRPPAEVVSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L CPED AL AARAIADRL NEMP+C+AGIGVAAGQV+AGNVGARERFEYTVIGEPVNE Sbjct 421 HLDCPEDAALTAARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVG 535 AARLCELAKS +LLA+ A++ ASE+ERARWSLG V LRGH++P RLA P G Sbjct 481 AARLCELAKSHSSRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLASPAG 535 >gi|342858019|ref|ZP_08714675.1| hypothetical protein MCOL_04055 [Mycobacterium colombiense CECT 3035] gi|342135352|gb|EGT88518.1| hypothetical protein MCOL_04055 [Mycobacterium colombiense CECT 3035] Length=539 Score = 785 bits (2027), Expect = 0.0, Method: Compositional matrix adjust. Identities = 401/534 (76%), Positives = 450/534 (85%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MS +S AQR+GRVLE VTRQSGRLPETPAYGS LLGRVSESQ RRR+RIQ+++T LV+ Sbjct 1 MSPNQSVAQRIGRVLERVTRQSGRLPETPAYGSLLLGRVSESQGRRRIRIQIIMTVLVLG 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANLLGIG L+LV +AIP PSI D P WLTFGV P Y++LAL +G+ +TR+TV ALRW Sbjct 61 ANLLGIGAGLILVIVAIPVPSIFDDAPAWLTFGVAPAYIVLALTVGTVWITRRTVLALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R PT E+ER TF+APWR+A+ L+ WG G L T LYGL+N FIPRFL VSFCG Sbjct 121 AIEERTPTPEDERNTFIAPWRIALVDLVLWGTGALLYTVLYGLVNTMFIPRFLVGVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVAT +YL E +LRP AAQALEAGPPPRRLA GI+GRTM+VW LGSGVP++GIAL+ + Sbjct 181 VLVATGSYLLAELSLRPVAAQALEAGPPPRRLAAGIMGRTMMVWFLGSGVPIIGIALLTL 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FE+ L NLT+ QFA GVLI+S L+FG +LMWILAWLTATPVRVVRAAL+RVE G+LR Sbjct 241 FEIWLRNLTQTQFAVGVLIVSSAALIFGCMLMWILAWLTATPVRVVRAALQRVEEGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVA AAERE KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAEREMPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGSTQLVT+RPPA+VV +LN+FFAIVV+EVDRHHGLVNKFEGDASL IFGAPN Sbjct 361 AVVFIDIVGSTQLVTNRPPAEVVSVLNQFFAIVVEEVDRHHGLVNKFEGDASLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PED+ALAAAR I RL NEM E AGIGVAAGQ +AGNVGARERFEYTVIGEPVNE Sbjct 421 RLDSPEDEALAAARCITGRLANEMSELSAGIGVAAGQAVAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS +LLA+A AV+ ASE ER RWSLG V LRGH++P RLA PV Sbjct 481 AARLCELAKSHSSRLLATADAVERASENERERWSLGDTVTLRGHERPTRLASPV 534 >gi|254821322|ref|ZP_05226323.1| hypothetical protein MintA_15392 [Mycobacterium intracellulare ATCC 13950] Length=528 Score = 774 bits (1999), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/521 (76%), Positives = 447/521 (86%), Gaps = 0/521 (0%) Query 14 VLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLV 73 +LE VTRQSGRLPETPAYGS LLGRVSESQ RRRVRIQ+++T LV+ ANL+GI VAL LV Sbjct 1 MLERVTRQSGRLPETPAYGSLLLGRVSESQGRRRVRIQIIMTVLVLGANLIGIAVALFLV 60 Query 74 TIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEER 133 T+AIP PS+ D P W+TFG P Y++ A A G+Y +TR+TV ALRWAIE R+PT E+ER Sbjct 61 TVAIPVPSVFDDAPAWITFGASPAYIVAASAWGTYWITRRTVIALRWAIEEREPTPEDER 120 Query 134 RTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEF 193 TF+APWR+A+ L+ WGVGT LLTTLYG++N FIPRFL VSF GV+VATA+YL EF Sbjct 121 NTFVAPWRIALVDLVLWGVGTILLTTLYGMVNTLFIPRFLLVVSFGGVVVATASYLLAEF 180 Query 194 ALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQF 253 ALRP AAQALEAGPPPRR A GI+GRTMVVW LGS VPV+GI ++A+FE+VL NLT+ QF Sbjct 181 ALRPVAAQALEAGPPPRRFAAGIMGRTMVVWFLGSAVPVIGIMMLALFELVLRNLTQTQF 240 Query 254 ATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGEL 313 A VLI+SM L+FG +LMWILAWLTATPVRVVRAAL RVERG+LR +LVVFDGTELGEL Sbjct 241 AVAVLIVSMAPLIFGCVLMWILAWLTATPVRVVRAALARVERGDLRGDLVVFDGTELGEL 300 Query 314 QRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQL 373 QRGFN MV GLRERERVRDLFGRHVGREVA AAERER KLGGEERHVAVVFIDIVGSTQL Sbjct 301 QRGFNTMVDGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHVAVVFIDIVGSTQL 360 Query 374 VTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAA 433 VTS+PPA+VV +LN+FFAIVV+EVDR+ GLVNKFEGDA+L IFGAPNRL PED ALAAA Sbjct 361 VTSQPPAEVVAVLNRFFAIVVEEVDRYCGLVNKFEGDATLAIFGAPNRLDSPEDAALAAA 420 Query 434 RAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPG 493 R IA+RL +EM + +AGIGVAAGQV+AGNVGA+ERFEYTVIGEPVNEAARLCELAKS Sbjct 421 RCIAERLADEMSDLEAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAARLCELAKSHTN 480 Query 494 KLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 +LLA+A A++ ASE+ERARWSLG V LRGH++P RLA V Sbjct 481 RLLATADAIEGASEDERARWSLGETVTLRGHERPTRLASLV 521 >gi|183984050|ref|YP_001852341.1| adenylate cyclase [Mycobacterium marinum M] gi|183177376|gb|ACC42486.1| adenylate cyclase [Mycobacterium marinum M] Length=534 Score = 736 bits (1901), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/534 (71%), Positives = 437/534 (82%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M + + QRL RV V Q +L E PAYGSWLLG+V E+QR RR+RIQV+LT+++V Sbjct 1 MVSTTAVGQRLRRVFVQVIDQGDQLTEPPAYGSWLLGQVLENQRSRRIRIQVILTSVIVF 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANL+GIGV LL+ +AIP P++ D P W+TF V P Y+++AL LG+Y +TR+TVQ LRW Sbjct 61 ANLVGIGVVLLIAIVAIPAPNVFTDAPWWVTFVVAPAYIVVALVLGTYWITRRTVQTLRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 A+E R P+R + R TF P +VA+ WGVG T LYGL N FIPRFLF VS CG Sbjct 121 ALEERPPSRADARSTFRVPRQVALATATLWGVGAVASTILYGLANPLFIPRFLFTVSICG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVAT YL TEFALRP AAQALEA PPP+R APGI+GRTM+VWLLGSG P+VGI LMA+ Sbjct 181 VLVATGAYLLTEFALRPVAAQALEAAPPPQRFAPGIMGRTMMVWLLGSGGPLVGINLMAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 E+V +LT++QFA GV+I+S TL+FGFILMWI++WLTATPVRVVRAAL RV G+L+ Sbjct 241 SELVKGSLTKVQFAIGVVIVSTGTLIFGFILMWIMSWLTATPVRVVRAALNRVANGDLQR 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNTMVDGLRERERVRDLFGRHVGREVAIAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGST+LVTS+PPADVV LLN+FFA+VVDEVDRH GLVNKF GDASL IFGAPN Sbjct 361 AVVFIDIVGSTKLVTSQPPADVVALLNRFFAVVVDEVDRHCGLVNKFAGDASLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L PED+ALAAAR IA RL +E+PEC+AGIGVAAGQV+AGNVG++ERFEYTVIGEPVNE Sbjct 421 HLERPEDQALAAARTIAARLASEVPECRAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAK PG+LLAS A+D AS +ERARWS+G+ V LRGHDQP RLA P+ Sbjct 481 AARLCELAKDHPGRLLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLAAPI 534 >gi|253799635|ref|YP_003032636.1| adenylate cyclase [Mycobacterium tuberculosis KZN 1435] gi|254231573|ref|ZP_04924900.1| hypothetical protein TBCG_01300 [Mycobacterium tuberculosis C] gi|289442760|ref|ZP_06432504.1| adenylate cyclase [Mycobacterium tuberculosis T46] 16 more sequence titles Length=535 Score = 736 bits (1901), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/534 (71%), Positives = 442/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIA+RL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRGH+QP RLA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 534 >gi|15608459|ref|NP_215835.1| adenylate cyclase [Mycobacterium tuberculosis H37Rv] gi|31792514|ref|NP_855007.1| adenylate cyclase [Mycobacterium bovis AF2122/97] gi|121637249|ref|YP_977472.1| putative adenylate cyclase [Mycobacterium bovis BCG str. Pasteur 1173P2] 13 more sequence titles Length=535 Score = 733 bits (1892), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/534 (71%), Positives = 442/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRGH+QP RLA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 534 >gi|148822541|ref|YP_001287295.1| adenylate cyclase [Mycobacterium tuberculosis F11] gi|254364217|ref|ZP_04980263.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] gi|254550331|ref|ZP_05140778.1| adenylate cyclase, putative [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|134149731|gb|EBA41776.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] gi|148721068|gb|ABR05693.1| adenylate cyclase [Mycobacterium tuberculosis F11] Length=558 Score = 732 bits (1889), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/534 (71%), Positives = 441/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIA+RL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|254364216|ref|ZP_04980262.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] gi|134149730|gb|EBA41775.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] Length=532 Score = 731 bits (1888), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/530 (72%), Positives = 435/530 (83%), Gaps = 0/530 (0%) Query 4 KKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANL 63 K+ QRL RVLET+TRQ RL + PAYGSWLLG VSE RRRVRIQ++LT ++TANL Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 LGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIE 123 +GIG+A+LL +A P PSIV D P W+TF P Y ++ +ALGSY + QT+ ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 GRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV 183 P+R ++R T LAP RVAVG L+ W VG AL TTLYGL N FIP+ +F+ FCGVLV Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEM 243 ATA Y+ TEFALRP AAQALEAG PP R A GI+GRTMVVWLL SGVP+ GIAL+ + EM Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 VLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLV 303 VL N T +QFA GVLI+S TL+ GF+LMWILAWLTA PVRVVRAAL+RVE+G+LR +LV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWILAWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVV 363 VFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLP 423 F+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 CPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAAR 483 PED ALAAARAIA+RL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 LCELAKS P +LLAS+ + AASE ERA WSLG V LRGH+QP RLA P Sbjct 482 LCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|339631387|ref|YP_004723029.1| adenylate cyclase [Mycobacterium africanum GM041182] gi|340626335|ref|YP_004744787.1| putative adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|339330743|emb|CCC26414.1| putative adenylate cyclase (ATP pyrophosphate-lyase) [Mycobacterium africanum GM041182] gi|340004525|emb|CCC43668.1| putative adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium canettii CIPT 140010059] Length=534 Score = 730 bits (1884), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/534 (71%), Positives = 441/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|298524824|ref|ZP_07012233.1| adenylate cyclase [Mycobacterium tuberculosis 94_M4241A] gi|298494618|gb|EFI29912.1| adenylate cyclase [Mycobacterium tuberculosis 94_M4241A] Length=532 Score = 730 bits (1884), Expect = 0.0, Method: Compositional matrix adjust. Identities = 375/530 (71%), Positives = 435/530 (83%), Gaps = 0/530 (0%) Query 4 KKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANL 63 K+ QRL RVLET+TRQ RL + PAYGSWLLG VSE RRRVRIQ++LT ++TANL Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 LGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIE 123 +GIG+A+LL +A P PSIV D P W+TF P Y ++ +ALGSY + QT+ ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 GRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV 183 P+R ++R T LAP RVAVG L+ W VG AL TTLYGL N FIP+ +F+ FCGVLV Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEM 243 ATA Y+ TEFALRP AAQALEAG PP R A GI+GRTMVVWLL SGVP+ GIAL+ + EM Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 VLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLV 303 VL N T +QFA GVLI+S TL+ GF+LMWI++WLTA PVRVVRAAL+RVE+G+LR +LV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVV 363 VFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLP 423 F+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 CPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAAR 483 PED ALAAARAIA+RL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 LCELAKS P +LLAS+ + AASE ERA WSLG V LRGH+QP RLA P Sbjct 482 LCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|15840772|ref|NP_335809.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|289573984|ref|ZP_06454211.1| adenylate cyclase [Mycobacterium tuberculosis K85] gi|13880965|gb|AAK45623.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|289538415|gb|EFD42993.1| adenylate cyclase [Mycobacterium tuberculosis K85] Length=558 Score = 729 bits (1881), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/534 (71%), Positives = 441/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|289745069|ref|ZP_06504447.1| adenylate cyclase [Mycobacterium tuberculosis 02_1987] gi|294994875|ref|ZP_06800566.1| adenylate cyclase, putative [Mycobacterium tuberculosis 210] gi|289685597|gb|EFD53085.1| adenylate cyclase [Mycobacterium tuberculosis 02_1987] gi|339294301|gb|AEJ46412.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5079] gi|339297940|gb|AEJ50050.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5180] Length=558 Score = 727 bits (1877), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/534 (71%), Positives = 440/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNWFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|15840771|ref|NP_335808.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|289446914|ref|ZP_06436658.1| adenylate cyclase, putative [Mycobacterium tuberculosis CPHL_A] gi|289745068|ref|ZP_06504446.1| adenylate cyclase [Mycobacterium tuberculosis 02_1987] 10 more sequence titles Length=532 Score = 727 bits (1876), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/530 (71%), Positives = 435/530 (83%), Gaps = 0/530 (0%) Query 4 KKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANL 63 K+ QRL RVLET+TRQ RL + PAYGSWLLG VSE RRRVRIQ++LT ++TANL Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 LGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIE 123 +GIG+A+LL +A P PSIV D P W+TF P Y ++ +ALGSY + QT+ ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 GRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV 183 P+R ++R T LAP RVAVG L+ W VG AL TTLYGL N FIP+ +F+ FCGVLV Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEM 243 ATA Y+ TEFALRP AAQALEAG PP R A GI+GRTMVVWLL SGVP+ GIAL+ + EM Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 VLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLV 303 VL N T +QFA GVLI+S TL+ GF+LMWI++WLTA PVRVVRAAL+RVE+G+LR +LV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVV 363 VFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLP 423 F+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 CPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAAR 483 PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 LCELAKS P +LLAS+ + AASE ERA WSLG V LRGH+QP RLA P Sbjct 482 LCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|326902942|gb|EGE49875.1| LOW QUALITY PROTEIN: adenylate cyclase [Mycobacterium tuberculosis W-148] Length=535 Score = 726 bits (1873), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/534 (71%), Positives = 439/534 (83%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+ +Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIDTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNWFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|340626334|ref|YP_004744786.1| adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|340004524|emb|CCC43667.1| adenylate cyclase, putative [Mycobacterium canettii CIPT 140010059] Length=532 Score = 724 bits (1870), Expect = 0.0, Method: Compositional matrix adjust. Identities = 375/530 (71%), Positives = 434/530 (82%), Gaps = 0/530 (0%) Query 4 KKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANL 63 K+ QRL RVLET+TRQ RL + PAYGSWLLG VSE RRRVRIQ++LT ++TANL Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 LGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIE 123 +GIG+A+LL +A P PSIV D P W+TF P Y ++ +ALGSY + QT+ ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 GRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV 183 P+R ++R T LAP RVAVG L+ W VG AL TTLYGL N FIP+ +F+ FCGVLV Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEM 243 ATA Y+ TEFALRP AAQALEAG PP R A GI+GRTMVVWLL SGVP+ GIAL+ + EM Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 VLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLV 303 VL N T +QFA GVLI+S TL+ GF+LMWI++WLTA PVRVVRAAL+RVE+G+LR +LV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVV 363 VFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLP 423 F+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 CPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAAR 483 PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 LCELAKS P +LLAS+ + ASE ERA WSLG V LRGH+QP RLA P Sbjct 482 LCELAKSHPARLLASSDTLHGASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|289446915|ref|ZP_06436659.1| adenylate cyclase, putative [Mycobacterium tuberculosis CPHL_A] gi|289419873|gb|EFD17074.1| adenylate cyclase, putative [Mycobacterium tuberculosis CPHL_A] Length=557 Score = 723 bits (1867), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/534 (71%), Positives = 440/534 (83%), Gaps = 2/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREV AAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREV-AAAERERPQLGGEDRH 359 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 360 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 419 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 NRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN Sbjct 420 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 479 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +AARLCELAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 480 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 533 >gi|183984051|ref|YP_001852342.1| adenylate cyclase [Mycobacterium marinum M] gi|183177377|gb|ACC42487.1| adenylate cyclase [Mycobacterium marinum M] Length=539 Score = 723 bits (1866), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/539 (68%), Positives = 441/539 (82%), Gaps = 0/539 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M A + QRL R LE +T+QS +L E AYGS LLG+++E+ +RRRVRIQ+MLT+ ++ Sbjct 1 MVATNTVVQRLRRALEKITQQSDQLTENYAYGSRLLGQLTETPQRRRVRIQLMLTSSIMA 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANL+ IGVALLLV +AIPEP+++ + PRWLTFGV GY + A +GS+ +T TV+ALRW Sbjct 61 ANLVAIGVALLLVFVAIPEPNVITEAPRWLTFGVGAGYDVTAFVVGSFWITSNTVRALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 IEGR P R E R TFL P R+A HL WG+GT L TTLYGLI+ FIP++LF+VSFCG Sbjct 121 YIEGRPPNRAESRETFLVPSRIAAVHLFLWGLGTLLFTTLYGLIDIRFIPKYLFSVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 +LVAT +YL TEFALRP AQALE GPPPRR+ GI+GRT+++WLLGSGVPVVGIAL+A+ Sbjct 181 ILVATGSYLLTEFALRPLTAQALETGPPPRRIVSGIMGRTILIWLLGSGVPVVGIALLAV 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FE+ LL+L+ ++FA GVLI S TLVFG +L+ I AWLTATPVRVVRAAL+RVERG+LR Sbjct 241 FEIALLHLSEVEFAVGVLIASSATLVFGLLLIAISAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 ++VVFDG+ELGELQ GFN+MV GLRERERVRDLFGRHVGREVAAAAER+ +LGGEER+V Sbjct 301 DVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAAERKPPQLGGEERYV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DI+GSTQLV++RP DVV+LLN+FFA++VDEV+RH GLVNKFEGDASL IFGAPN Sbjct 361 AVVFVDIIGSTQLVSNRPATDVVQLLNRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L CPE AL+AARAIA RL E+PEC+AGIGVAAGQV+AGNVGA ERFEYTVIG PVNE Sbjct 421 PLECPEVAALSAARAIAGRLCTEVPECRAGIGVAAGQVVAGNVGANERFEYTVIGGPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKP 539 AARLCELAKS +L+AS++ V A+E ERA W+L V LRG D+P RLA P +P Sbjct 481 AARLCELAKSYSARLVASSETVAGATETERAHWNLAETVTLRGRDRPTRLAIPASSPRP 539 >gi|289446916|ref|ZP_06436660.1| adenylate cyclase [Mycobacterium tuberculosis CPHL_A] gi|289419874|gb|EFD17075.1| adenylate cyclase [Mycobacterium tuberculosis CPHL_A] Length=567 Score = 722 bits (1863), Expect = 0.0, Method: Compositional matrix adjust. Identities = 369/534 (70%), Positives = 428/534 (81%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASLT+FGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLTVFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RLA PV Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPV 534 >gi|340626336|ref|YP_004744788.1| putative adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|340004526|emb|CCC43669.1| putative adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium canettii CIPT 140010059] Length=567 Score = 721 bits (1861), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/534 (69%), Positives = 427/534 (80%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MQSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RLA PV Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPV 534 >gi|120405263|ref|YP_955092.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii PYR-1] gi|119958081|gb|ABM15086.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii PYR-1] Length=536 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 371/535 (70%), Positives = 437/535 (82%), Gaps = 1/535 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M+A KS RLGRVLE VTRQSGRL ETP YGSWLLG+ ESQ RRR+RIQV+LT L++ Sbjct 1 MNATKSVPYRLGRVLERVTRQSGRL-ETPDYGSWLLGKPEESQARRRIRIQVILTFLLLF 59 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N+LGI V+LLL T+AIP PS+ D P WLTFGVVP Y+++AL LG+ +T +TV +LRW Sbjct 60 TNILGIAVSLLLNTVAIPVPSVFSDAPAWLTFGVVPAYMVVALVLGTAWITSRTVGSLRW 119 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R PTR ++R F+AP RVA L+FWG G ALLT LYGL ++AFIPRFLFAV F G Sbjct 120 AIEERSPTRTDQRNVFVAPSRVAQMLLLFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPG 179 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 ++VATA Y+ TEFALRP AAQALEAG PPRRLA G++GRTM VWLL SGVPV+GI L+A+ Sbjct 180 IVVATACYMITEFALRPVAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAI 239 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F + L NL+ QFA V+IIS+V L+FG ILMW+L+WL ATPVRVVR+AL+ VE G+L Sbjct 240 FTLSLRNLSATQFAVAVMIISVVALMFGLILMWLLSWLIATPVRVVRSALKHVEDGDLDC 299 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 N+VVFDGTELGELQRGFN+MV GLRERERVRDLFGRHVGREVA AAE+++ +LGGEERH Sbjct 300 NVVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVARAAEKQKIELGGEERHA 359 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AV+F+DI+GSTQLVTSRP +VV+LLN+FF +VV+EVD HHGLVNKFEGDA L +FGAP Sbjct 360 AVIFVDIIGSTQLVTSRPAVEVVELLNRFFDVVVEEVDNHHGLVNKFEGDAVLAVFGAPV 419 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L E +AL+AARA+A RL E+PEC AGIGVAAGQV+AGNVGA++RFEYTVIGEPVNE Sbjct 420 SLDSAETEALSAARAMARRLRTEVPECPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNE 479 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVG 535 AARLCELAK+ P L+ASA AV A+E ERA W LG V LRGHDQP RLA P G Sbjct 480 AARLCELAKNVPALLVASADAVGGATESERALWKLGETVTLRGHDQPTRLATPAG 534 >gi|15840773|ref|NP_335810.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|31792515|ref|NP_855008.1| adenylate cyclase [Mycobacterium bovis AF2122/97] gi|121637250|ref|YP_977473.1| putative adenylate cyclase [Mycobacterium bovis BCG str. Pasteur 1173P2] 64 more sequence titles Length=567 Score = 720 bits (1859), Expect = 0.0, Method: Compositional matrix adjust. Identities = 368/534 (69%), Positives = 427/534 (80%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RLA PV Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPV 534 >gi|289757423|ref|ZP_06516801.1| adenylate cyclase [Mycobacterium tuberculosis T85] gi|289712987|gb|EFD76999.1| adenylate cyclase [Mycobacterium tuberculosis T85] Length=552 Score = 719 bits (1855), Expect = 0.0, Method: Compositional matrix adjust. Identities = 373/527 (71%), Positives = 435/527 (83%), Gaps = 1/527 (0%) Query 8 AQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIG 67 AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++TANL GI Sbjct 2 AQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIV 61 Query 68 VALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LRWAIEGRK 126 VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +RWAIE R Sbjct 62 VALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERA 121 Query 127 PTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATA 186 P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ CGVLVAT Sbjct 122 PSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATN 181 Query 187 TYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLL 246 YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A++ +++ Sbjct 182 CYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVH 241 Query 247 NLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFD 306 NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR +LVVFD Sbjct 242 NLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFD 301 Query 307 GTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFID 366 GTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVVF+D Sbjct 302 GTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVD 361 Query 367 IVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPE 426 IVGSTQLV ++P A VVKLLN FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL PE Sbjct 362 IVGSTQLVDNQPAAHVVKLLNWFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPE 421 Query 427 DKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCE 486 D ALAAARAIADRL NEMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN+AARLCE Sbjct 422 DAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCE 481 Query 487 LAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 LAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 482 LAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 528 >gi|298524825|ref|ZP_07012234.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|298494619|gb|EFI29913.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] Length=552 Score = 719 bits (1855), Expect = 0.0, Method: Compositional matrix adjust. Identities = 372/527 (71%), Positives = 436/527 (83%), Gaps = 1/527 (0%) Query 8 AQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIG 67 AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++TANL GI Sbjct 2 AQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIV 61 Query 68 VALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LRWAIEGRK 126 VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +RWAIE R Sbjct 62 VALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERA 121 Query 127 PTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATA 186 P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ CGVLVAT Sbjct 122 PSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATN 181 Query 187 TYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLL 246 YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A++ +++ Sbjct 182 CYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVH 241 Query 247 NLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFD 306 NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR +LVVFD Sbjct 242 NLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFD 301 Query 307 GTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFID 366 GTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVVF+D Sbjct 302 GTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVD 361 Query 367 IVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPE 426 IVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL PE Sbjct 362 IVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPE 421 Query 427 DKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCE 486 D ALAAARAIADRL +EMPE QAGIGVAAGQ++AGNVGA++RFEYTV+G+PVN+AARLCE Sbjct 422 DAALAAARAIADRLASEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCE 481 Query 487 LAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 LAKS P +LLAS+ + AASE ERA WSLG V LRG+ QP +LA P Sbjct 482 LAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 528 >gi|15608460|ref|NP_215836.1| adenylate cyclase [Mycobacterium tuberculosis H37Rv] gi|148661108|ref|YP_001282631.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] gi|167967592|ref|ZP_02549869.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] gi|1722970|sp|Q10633.1|Y1320_MYCTU RecName: Full=Uncharacterized protein Rv1320c/MT1362 gi|1340086|emb|CAA98107.1| POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE) [Mycobacterium tuberculosis H37Rv] gi|148505260|gb|ABQ73069.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] Length=567 Score = 718 bits (1854), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/534 (69%), Positives = 426/534 (80%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RL PV Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 >gi|339631388|ref|YP_004723030.1| adenylate cyclase [Mycobacterium africanum GM041182] gi|339330744|emb|CCC26415.1| putative adenylate cyclase (ATP pyrophosphate-lyase) [Mycobacterium africanum GM041182] Length=567 Score = 717 bits (1852), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/534 (69%), Positives = 426/534 (80%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N++G+ V +L+T+A P+ S++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKSSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RLA PV Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPV 534 >gi|118619151|ref|YP_907483.1| adenylate cyclase [Mycobacterium ulcerans Agy99] gi|118571261|gb|ABL06012.1| adenylate cyclase [Mycobacterium ulcerans Agy99] Length=539 Score = 714 bits (1842), Expect = 0.0, Method: Compositional matrix adjust. Identities = 362/539 (68%), Positives = 438/539 (82%), Gaps = 0/539 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M A + QRL R LE +T+QS +L E AYGS LLG+++E+ +RRRVRIQ+MLT+ ++ Sbjct 1 MVATNTVVQRLRRALEKITQQSDQLTENYAYGSRLLGQLTETPQRRRVRIQLMLTSSIMA 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 ANL+ IGVALLLV +AIPEP+++ + PRWLTFGV GY + A +GS+ +T TV+ALRW Sbjct 61 ANLVAIGVALLLVFVAIPEPNVITEAPRWLTFGVGAGYDVTAFVVGSFWITSNTVRALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 IEGR P R R TFL P R+A HL WG+GT L TTLYGLI+ FIP++LF+VSFCG Sbjct 121 YIEGRPPNRAVSRETFLVPSRIAAVHLFLWGLGTLLFTTLYGLIDIRFIPKYLFSVSFCG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 +LVAT +YL TEFALRP AQALE GPPPRR+ GI+GRT+++WLLGSGVPVV IAL+A+ Sbjct 181 ILVATGSYLLTEFALRPLTAQALETGPPPRRIVSGIMGRTILIWLLGSGVPVVDIALLAV 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FE+ LL+L+ ++FA GVLI S TLVFG +L+ I AWLTATPVRVVRAAL+RVERG+LR Sbjct 241 FEIALLHLSEVEFAVGVLIASSATLVFGLLLIAISAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 ++VVFDG+ELGELQ GFN+MV GLRERERVRDLFGRHVGREVAAAAER+ +LGGEER+V Sbjct 301 DVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAAERKPPQLGGEERYV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVF+DI+GSTQLV++RP DVV+LL++FFA++VDEV+RH GLVNKFEGDASL IFGAPN Sbjct 361 AVVFVDIIGSTQLVSNRPATDVVQLLDRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L CPE AL+AARAIA RL E+PEC AGIGVAAGQV+AGNVGA ERFEYTVIG PVNE Sbjct 421 PLECPEVAALSAARAIAGRLCTEVPECPAGIGVAAGQVVAGNVGANERFEYTVIGGPVNE 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKP 539 AARLCELAKS +L+AS++ V A+E ERA W+L V LRG D+P RLA P +P Sbjct 481 AARLCELAKSYSTRLVASSETVAGATETERAHWNLAETVTLRGRDRPTRLAIPASSPRP 539 >gi|240169496|ref|ZP_04748155.1| putative adenylate cyclase [Mycobacterium kansasii ATCC 12478] Length=537 Score = 709 bits (1831), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/534 (69%), Positives = 432/534 (81%), Gaps = 0/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 MS++K+ AQRL RVL+ V R ETPAYGSWLLGR SESQ+R+R+RIQVM++ ++ Sbjct 1 MSSQKAVAQRLDRVLDKVARWFRWPSETPAYGSWLLGRASESQQRQRIRIQVMMSVTILA 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 A L+GI +A LL+T+A P+PS++ D PRWL+FG+VP Y +LA+ LG+ LTRQT +ALRW Sbjct 61 AQLVGITIAALLLTVAFPKPSVIFDAPRWLSFGLVPAYNVLAVVLGALWLTRQTTRALRW 120 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R PT +E R TF P RV++ L WG G AL TTLYG+ N FIPRFLF++S G Sbjct 121 AIEERTPTPDEARDTFRIPARVSLAVLFVWGFGMALWTTLYGMANPVFIPRFLFSMSVVG 180 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 VLVAT++YL +EFALRP AA+ALE GP R L PGI+ RTMVVWLL SG+P +GIAL A+ Sbjct 181 VLVATSSYLLSEFALRPVAARALEVGPTSRSLVPGIMSRTMVVWLLCSGLPNIGIALTAL 240 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 FE L Q+ VLI+ +VFGF+LMW+LAW+TATPV VVRAAL+RVE+G+L Sbjct 241 FENTFWELENDQYIVSVLILWTPVMVFGFVLMWMLAWMTATPVGVVRAALKRVEQGDLAG 300 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 +LVVFD TELGELQRGFNAMV GLRERERVRDLFGRHVGREVA AAER+ KLGGEERHV Sbjct 301 DLVVFDATELGELQRGFNAMVHGLRERERVRDLFGRHVGREVALAAERQPPKLGGEERHV 360 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AVVFIDIVGST+LVTS+PPADVV+LLN+FFA+V+DE+DRH GLVNKF+GDASL IFGAPN Sbjct 361 AVVFIDIVGSTKLVTSQPPADVVQLLNRFFAVVIDEIDRHRGLVNKFQGDASLAIFGAPN 420 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L PED+ALAAARAIA+RL NE+PEC AGIGVA+GQV+AGNVGA ERFEYTVIGEPVN+ Sbjct 421 HLDRPEDQALAAARAIAERLANEVPECPAGIGVASGQVVAGNVGANERFEYTVIGEPVNQ 480 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCELAKS PG+LLA+A V A+E E A WSLG V LRGHDQ RLA PV Sbjct 481 AARLCELAKSHPGQLLATADTVRGATEHESALWSLGEVVTLRGHDQQTRLASPV 534 >gi|333989962|ref|YP_004522576.1| adenylate cyclase [Mycobacterium sp. JDM601] gi|333485930|gb|AEF35322.1| adenylate cyclase [Mycobacterium sp. JDM601] Length=524 Score = 709 bits (1831), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/524 (69%), Positives = 422/524 (81%), Gaps = 0/524 (0%) Query 11 LGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVAL 70 +GRVLE +TRQ+ RLPETP YGSWLLGRVSESQ RR+RIQ +LT ++V NL+GIGV Sbjct 1 MGRVLELLTRQTDRLPETPEYGSWLLGRVSESQYLRRIRIQFILTVVIVGTNLIGIGVEA 60 Query 71 LLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTRE 130 LL+ +A P PS+ D P WLT+GVVP Y++LAL G+Y +TR+T++ LRWAI ++PTR Sbjct 61 LLLAVAFPSPSVFFDAPGWLTYGVVPAYIVLALIFGTYWITRRTIKKLRWAIREQQPTRV 120 Query 131 EERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLH 190 +ER FLAPWRVA L WGV L T LYG+ +N FIP F V CG+ VATA YL Sbjct 121 DERNAFLAPWRVAQVVLALWGVAAMLFTVLYGMADNYFIPIVAFTVGVCGIQVATACYLC 180 Query 191 TEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTR 250 TEFALRP AAQAL AGPPPRR GI+GRTM+VWLL SGVPV+GIAL A+F +VL NL+ Sbjct 181 TEFALRPVAAQALAAGPPPRRFFSGIMGRTMMVWLLSSGVPVLGIALTAIFALVLKNLSM 240 Query 251 MQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTEL 310 QF VL++++ T VFGF+LMWIL+WLTA PVRVVRAALRRVE+G L +LVVFDGTEL Sbjct 241 TQFGVAVLVVAVATAVFGFLLMWILSWLTAAPVRVVRAALRRVEQGNLGADLVVFDGTEL 300 Query 311 GELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGS 370 GELQ GFNAMV GLRERERVRDLFGRHVGREVAAAAER+R +LGGEERHVAV+F+DI+GS Sbjct 301 GELQSGFNAMVHGLRERERVRDLFGRHVGREVAAAAERDRIQLGGEERHVAVLFVDIIGS 360 Query 371 TQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKAL 430 TQ+VT++P +VV LLN+FFA+VVDEVDRH GL+NKFEGDASL IFGAPN L PED+AL Sbjct 361 TQIVTAKPATEVVTLLNRFFAVVVDEVDRHRGLINKFEGDASLAIFGAPNHLDQPEDEAL 420 Query 431 AAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKS 490 AA RAI RL +E+PE +AGIGVAAGQV+AGNVGA+ERFEYTVIGEPVNEAARL ELAK Sbjct 421 AAGRAILSRLADEVPEIRAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAARLSELAKI 480 Query 491 RPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 R +LL +A+ + AAS E+A W LG V LRG+DQP LA P+ Sbjct 481 RELQLLTTARTLRAASISEQAHWVLGDSVVLRGYDQPTVLAGPL 524 >gi|145222924|ref|YP_001133602.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK] gi|315443387|ref|YP_004076266.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1] gi|145215410|gb|ABP44814.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK] gi|315261690|gb|ADT98431.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1] Length=536 Score = 703 bits (1815), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/534 (68%), Positives = 428/534 (81%), Gaps = 1/534 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M+A KS RLGRVLE VTRQSGRL +TP YGSWLLGR +ESQ RRRVRIQ++LT ++ Sbjct 1 MNATKSVPYRLGRVLERVTRQSGRL-DTPGYGSWLLGRPAESQSRRRVRIQIILTFFILF 59 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 N++GI V+LLL TIAIP PS+ D P WLTFGV P Y+L+AL G+ +T +TV++LRW Sbjct 60 TNIMGIAVSLLLNTIAIPVPSVFSDAPAWLTFGVTPAYMLVALFFGTAWITSRTVRSLRW 119 Query 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 AIE R+PT ++R FLAP RVA L+ WGVG LLT LYGL + AFIPRFLFAV F G Sbjct 120 AIEERQPTSTDQRNVFLAPARVAQKLLLLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPG 179 Query 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 ++VATA Y+ TEFALRP AAQALEAG PPRRLA G++GRTM VWLL SGVPV+GI L+A+ Sbjct 180 IVVATACYMITEFALRPIAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAV 239 Query 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 F + L NL+ QFA V+ I+ LVFG LMW+L+WL ATPVRVVR+AL++VE G+L Sbjct 240 FSLSLKNLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIATPVRVVRSALKQVEDGDLDC 299 Query 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 NLVVFDGTELGELQRGFN+MV GLRERERVRDLFGRHVGREVA AAE+++ +LGGEER Sbjct 300 NLVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVALAAEKQQVELGGEERRA 359 Query 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 AV+F+DI+GST+LVTSRP A+VV+LLN+FF +VVDEVD+HHGLVNKFEGDA L +FGAP Sbjct 360 AVIFVDIIGSTKLVTSRPAAEVVELLNRFFDVVVDEVDKHHGLVNKFEGDAVLAVFGAPV 419 Query 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 L E +ALAAARA++ RL E+PEC AGIGVA+GQV+AGNVGA+ERFEYTVIGEPVNE Sbjct 420 SLDNAEAEALAAARAMSRRLAAEVPECTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNE 479 Query 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 AARLCEL+K G L+ASA AV A+E ER W LG V LRGH +P LA PV Sbjct 480 AARLCELSKKIDGHLVASADAVHNATETERRHWELGETVTLRGHAEPTTLATPV 533 >gi|108800832|ref|YP_641029.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS] gi|119869972|ref|YP_939924.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] gi|126436430|ref|YP_001072121.1| putative adenylate/guanylate cyclase [Mycobacterium sp. JLS] gi|108771251|gb|ABG09973.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS] gi|119696061|gb|ABL93134.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] gi|126236230|gb|ABN99630.1| putative adenylate/guanylate cyclase [Mycobacterium sp. JLS] Length=540 Score = 701 bits (1808), Expect = 0.0, Method: Compositional matrix adjust. Identities = 363/530 (69%), Positives = 439/530 (83%), Gaps = 0/530 (0%) Query 2 SAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTA 61 +AKKS QRLG +LE VTRQSGRLP+TP YGSWLLG+ E+Q+RRR+RIQ++LT L++ Sbjct 6 TAKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTFLILVT 65 Query 62 NLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWA 121 N+LGIGV+LLL +AIP PS+ D P WLT+GVVP Y+L+AL G+ +T V++LRWA Sbjct 66 NILGIGVSLLLNAVAIPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVRSLRWA 125 Query 122 IEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGV 181 IE R PTR ++ F APW+VA L+FWGVGTALLT LYGL ++AFIPRFLFAV F G+ Sbjct 126 IEERTPTRADQYNVFRAPWQVARMLLLFWGVGTALLTLLYGLQDSAFIPRFLFAVGFPGI 185 Query 182 LVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMF 241 +VATA YL TEFALRP AAQALEAG PPRRLA G++GRTM VWLL SGVPV+GI L+A+F Sbjct 186 VVATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGILLLAVF 245 Query 242 EMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTN 301 + + NL+ QF V+II++V L+FG ILMW+L+WL ATPVRVVRAAL+ VERG+ Sbjct 246 SLSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERGDFDCQ 305 Query 302 LVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVA 361 LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAE+E+ +LGGEERH A Sbjct 306 LVVFDGTELGELQRGFNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGEERHAA 365 Query 362 VVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNR 421 V+F+DI+GSTQ+VTSRP +++V+LLN+FFA++VDEVDRHHGLVNKFEGDA L +FGAP Sbjct 366 VIFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDEVDRHHGLVNKFEGDAVLAVFGAPVA 425 Query 422 LPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEA 481 L +ALAAARAIA+RL +E+P+C+AGIGVAAGQV+AGNVGA+ERFEYTVIGEPVNEA Sbjct 426 LDNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEA 485 Query 482 ARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLA 531 ARLCELAKS P +L+AS+ V AA++ ERA W+LG V LRGHD+P LA Sbjct 486 ARLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTLA 535 >gi|118473953|ref|YP_889179.1| adenylate cyclase, family protein 3 [Mycobacterium smegmatis str. MC2 155] gi|118175240|gb|ABK76136.1| adenylate cyclase, family protein 3 [Mycobacterium smegmatis str. MC2 155] Length=535 Score = 692 bits (1785), Expect = 0.0, Method: Compositional matrix adjust. Identities = 347/535 (65%), Positives = 421/535 (79%), Gaps = 1/535 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPE-TPAYGSWLLGRVSESQRRRRVRIQVMLTALVV 59 M+A S A++LGRVLETVTRQ+ RLP TP YGSW+LGRV+ESQ RRR+RIQ++LT VV Sbjct 1 MNADNSLARQLGRVLETVTRQNSRLPSGTPEYGSWILGRVTESQSRRRIRIQLILTTFVV 60 Query 60 TANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALR 119 ANLLGI V+ L++T+ P PS+ T+ V P YV+ AL +G T + + +R Sbjct 61 IANLLGIAVSFLVLTVLFPSPSVFDARVAPYTYIVAPAYVVGALVVGVIWATNRVIGNVR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WA+E R PT +++R TF AP+R+ L+ W GTALLTTLYG+++ FIP+ L +SF Sbjct 121 WALEERPPTPQDQRNTFFAPFRLTRVLLILWAAGTALLTTLYGMVDTNFIPKVLLGISFP 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 G++V+ + +L TEFALRP AAQALEAGPPP RLAPGI+GRTMVVW LGSGVP++GI L Sbjct 181 GIVVSVSCHLFTEFALRPVAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPILGILLAG 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 +F + L NLT QFA V+ +++ LVFGFILMWIL+WLTATP+RVVRAAL RVE+G+L Sbjct 241 VFAVTLENLTPTQFAYAVMGLAVFALVFGFILMWILSWLTATPIRVVRAALNRVEQGDLD 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 TNLVVFDGTELG+LQRGFN+MV GLRERERVRDLFGRHVGREVA AE+++ LGGEERH Sbjct 301 TNLVVFDGTELGQLQRGFNSMVHGLRERERVRDLFGRHVGREVAVLAEQQKFTLGGEERH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+D++GSTQLVTSRP +VV+LLN+FFA++VDEVD H GLVNKFEGDA L +FGAP Sbjct 361 AAVVFVDVIGSTQLVTSRPAVEVVELLNRFFAVIVDEVDAHRGLVNKFEGDAVLAVFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 479 L ED+AL AAR IA RL E+PE AGIGVAAGQV+AGNVGA++RFEYTVIGEPVN Sbjct 421 VALDNAEDEALGAARGIARRLREEVPELDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVN 480 Query 480 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 EAARLCE AKS PG ++AS+ + ASE ERARWSLG V LRG D+P RLA PV Sbjct 481 EAARLCEFAKSVPGHVVASSDTLANASESERARWSLGESVTLRGLDEPTRLAVPV 535 >gi|183984091|ref|YP_001852382.1| adenylate cyclase [Mycobacterium marinum M] gi|183177417|gb|ACC42527.1| adenylate cyclase [Mycobacterium marinum M] Length=527 Score = 685 bits (1768), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/520 (69%), Positives = 423/520 (82%), Gaps = 0/520 (0%) Query 15 LETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVT 74 ++TVTR G L E+PAYGSWLLG ++ESQR RR+RIQ MLTA++ N++GI V L+L T Sbjct 1 MKTVTRHDGSLLESPAYGSWLLGDLNESQRDRRIRIQGMLTAVIAATNVIGICVGLVLAT 60 Query 75 IAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEERR 134 +A P P ++ D P W+TF V+P YV++A ALGSY LTR+T Q LRWAIE R+P+ ++R Sbjct 61 VAAPAPHVLSDAPLWITFAVMPAYVVIAFALGSYWLTRRTTQMLRWAIERREPSPTDQRN 120 Query 135 TFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFA 194 T LAP+R A+ HL+ WG T LLT LYG+ N+ FIPRFLFA+SFCG+ V TA+Y+ TEFA Sbjct 121 TLLAPFRFAIFHLLVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEFA 180 Query 195 LRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQFA 254 LRP AA AL AGPP R APGI GRT+VVWL GSGVP++G+AL+ +F+ L +++ +F+ Sbjct 181 LRPVAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLIGMALVVIFDESLWQISQAEFS 240 Query 255 TGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQ 314 V+I+S L G +LMWIL+WLT TPV+VV AAL+RVE G+L +LVVFDGTELG+LQ Sbjct 241 ISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRVEMGDLPGDLVVFDGTELGQLQ 300 Query 315 RGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLV 374 RGFNAMVAGLRERERVRDLFGRHVGREVAAAAERER KLGGE+RH+AVVFIDIVGST+LV Sbjct 301 RGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERPKLGGEDRHIAVVFIDIVGSTRLV 360 Query 375 TSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAAR 434 T++PPA+VVKLLN+FFAIVVDEVDRH GLVNKF GDA+L IFGAPNRL PED+ALAAAR Sbjct 361 TTQPPAEVVKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAAR 420 Query 435 AIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGK 494 AIA RL E+PECQAGIGVAAGQ +AGNVGA ERFEYT IGEPVNEAARLCELAKS PG+ Sbjct 421 AIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPGR 480 Query 495 LLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 LLASA+ + ASE A+W LG LRG QP RLA P+ Sbjct 481 LLASAETLAGASESVSAQWCLGDSTLLRGLGQPTRLATPI 520 >gi|289573983|ref|ZP_06454210.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] gi|289538414|gb|EFD42992.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] Length=496 Score = 683 bits (1763), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/495 (72%), Positives = 409/495 (83%), Gaps = 0/495 (0%) Query 39 VSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGY 98 +SE RRRVRIQ++LT ++TANL+GIG+A+LL +A P PSIV D P W+TF P Y Sbjct 1 MSERPLRRRVRIQIILTIALITANLVGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAY 60 Query 99 VLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLT 158 ++ +ALGSY + QT+ ALRWA E P+R ++R T LAP RVAVG L+ W VG AL T Sbjct 61 TVIGMALGSYYVKVQTLAALRWASEEHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFT 120 Query 159 TLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILG 218 TLYGL N FIP+ +F+ FCGVLVATA Y+ TEFALRP AAQALEAG PP R A GI+G Sbjct 121 TLYGLANRLFIPQVMFSTLFCGVLVATACYMLTEFALRPVAAQALEAGLPPGRFALGIIG 180 Query 219 RTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWL 278 RTMVVWLL SGVP+ GIAL+ + EMVL N T +QFA GVLI+S TL+ GF+LMWI++WL Sbjct 181 RTMVVWLLSSGVPLFGIALLGILEMVLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWL 240 Query 279 TATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHV 338 TA PVRVVRAAL+RVE+G+LR +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHV Sbjct 241 TAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHV 300 Query 339 GREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVD 398 GREVAAAAERER +LGGE+RH AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVD Sbjct 301 GREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVD 360 Query 399 RHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQV 458 RHHGL+NKF GDA+L IFGAPNRL PED ALAAARAIADRL NEMPE QAGIGVAAGQ+ Sbjct 361 RHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQI 420 Query 459 IAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRH 518 +AGNVGA++RFEYTV+G+PVN+AARLCELAKS P +LLAS+ + AASE ERA WSLG Sbjct 421 VAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGET 480 Query 519 VKLRGHDQPVRLAKP 533 V LRGH+QP RLA P Sbjct 481 VTLRGHEQPTRLAVP 495 >gi|118619189|ref|YP_907521.1| adenylate cyclase [Mycobacterium ulcerans Agy99] gi|118571299|gb|ABL06050.1| adenylate cyclase [Mycobacterium ulcerans Agy99] Length=528 Score = 682 bits (1761), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/521 (68%), Positives = 424/521 (82%), Gaps = 0/521 (0%) Query 14 VLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLV 73 +++TVTR G L E+PAYGSWLLG ++ESQR RR+RI+ MLTA++ N++GI V L+L Sbjct 1 MVKTVTRHDGSLLESPAYGSWLLGDLNESQRDRRIRIRGMLTAVIAATNVIGICVGLVLA 60 Query 74 TIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEER 133 T+A P P ++ D P W+TF V+P YV++A ALGSY L R+T Q LRWAIE R+P+ ++R Sbjct 61 TVAAPAPHVLSDAPLWITFAVMPAYVVIAFALGSYWLARRTTQMLRWAIERREPSPTDQR 120 Query 134 RTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEF 193 T LAP+R A+ HL+ WG T LLT LYG+ N+ FIPRFLFA+SFCG+ V TA+Y+ TEF Sbjct 121 NTLLAPFRFAIFHLLVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEF 180 Query 194 ALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQF 253 ALRP AA AL AGPP R APGI GRT+VVWL GSGVP++G+AL+ +F+ L +++ +F Sbjct 181 ALRPVAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLIGMALVVIFDESLWQISQAEF 240 Query 254 ATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGEL 313 + V+I+S L G +LMWIL+WLT TPV+VV AAL+RVE G+L +LVVFDGTELG+L Sbjct 241 SISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRVEMGDLPGDLVVFDGTELGQL 300 Query 314 QRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQL 373 QRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERER KLGGE+RH+AVVFIDIVGST+L Sbjct 301 QRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERPKLGGEDRHIAVVFIDIVGSTRL 360 Query 374 VTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAA 433 VT++PPA+VVKLLN+FFAIVVDEVDRH GLVNKF GDA+L IFGAPNRL PED+ALAAA Sbjct 361 VTTQPPAEVVKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAA 420 Query 434 RAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPG 493 RAIA RL E+PECQAGIGVAAGQ +AGNVGA ERFEYT IGEPVNEAARLCELAKS PG Sbjct 421 RAIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPG 480 Query 494 KLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 +LLASA+ + ASE A+W LG LRG DQP RLA P+ Sbjct 481 RLLASAETLAGASESVSAQWCLGDSTLLRGLDQPTRLATPI 521 >gi|339294302|gb|AEJ46413.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5079] gi|339297941|gb|AEJ50051.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5180] Length=523 Score = 670 bits (1728), Expect = 0.0, Method: Compositional matrix adjust. Identities = 342/489 (70%), Positives = 392/489 (81%), Gaps = 0/489 (0%) Query 46 RRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALAL 105 RRVRIQ MLT ++ N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA L Sbjct 2 RRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFIL 61 Query 106 GSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLIN 165 G+Y LTRQT +ALRWAIE R P+ +E R FL P RVA+ L WG AL T +YGL N Sbjct 62 GTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLAN 121 Query 166 NAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWL 225 FIPRFLF++ GV+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWL Sbjct 122 RLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWL 181 Query 226 LGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRV 285 L SGVP VG+AL A+F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRV Sbjct 182 LCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRV 241 Query 286 VRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAA 345 VR AL RVE+G+L +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAA Sbjct 242 VREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAA 301 Query 346 AERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVN 405 AERER KLGGEERHVAVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVN Sbjct 302 AERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVN 361 Query 406 KFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGA 465 KF+GDASL +FGAPNRL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA Sbjct 362 KFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGA 421 Query 466 RERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHD 525 ERFEYTVIGEPVNEAARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHD Sbjct 422 HERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHD 481 Query 526 QPVRLAKPV 534 QP+RLA PV Sbjct 482 QPIRLASPV 490 >gi|308399382|ref|ZP_07492998.2| adenylate cyclase [Mycobacterium tuberculosis SUMu012] gi|308366468|gb|EFP55319.1| adenylate cyclase [Mycobacterium tuberculosis SUMu012] Length=523 Score = 668 bits (1724), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/489 (70%), Positives = 391/489 (80%), Gaps = 0/489 (0%) Query 46 RRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALAL 105 RRVRIQ MLT ++ N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA L Sbjct 2 RRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFIL 61 Query 106 GSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLIN 165 G+Y LTRQT +ALRWAIE R P+ +E R FL P RVA+ L WG AL T +YGL N Sbjct 62 GTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLAN 121 Query 166 NAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWL 225 FIPRFLF++ GV+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWL Sbjct 122 RLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWL 181 Query 226 LGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRV 285 L SGVP VG+AL A+F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRV Sbjct 182 LCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRV 241 Query 286 VRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAA 345 VR AL RVE+G+L +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAA Sbjct 242 VREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAA 301 Query 346 AERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVN 405 AERER KLGGEERHVAVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVN Sbjct 302 AERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVN 361 Query 406 KFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGA 465 KF+GDASL +FGAPNRL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA Sbjct 362 KFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGA 421 Query 466 RERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHD 525 ERFEYTVIGEPVNEAARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHD Sbjct 422 HERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHD 481 Query 526 QPVRLAKPV 534 QP+RL PV Sbjct 482 QPIRLTSPV 490 >gi|183983769|ref|YP_001852060.1| adenylate cyclase [Mycobacterium marinum M] gi|183177095|gb|ACC42205.1| adenylate cyclase [Mycobacterium marinum M] Length=549 Score = 644 bits (1661), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/523 (63%), Positives = 410/523 (79%), Gaps = 0/523 (0%) Query 11 LGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVAL 70 L R+L T + GRL AYGS LLG +RR +RI+ M T ++ NL+GI V L Sbjct 11 LHRLLNVPTDKGGRLAAARAYGSRLLGDAGVPPKRRWIRIRTMSTVAILGINLIGICVML 70 Query 71 LLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTRE 130 +L+T+A+PEP+++ + P WL +GV P Y ++AL LG++ +T +ALRW IEGR+P+ Sbjct 71 VLLTLAVPEPNVLSEAPAWLNYGVGPAYNVIALTLGTWWITALAKRALRWYIEGRRPSLT 130 Query 131 EERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLH 190 E TF P RVA + WG+GT +TTLYGLI+ FI ++LF+VSFCG+LV T +YL Sbjct 131 EATETFRIPSRVAAVNFFLWGLGTLTMTTLYGLIDTRFIAKYLFSVSFCGILVCTGSYLL 190 Query 191 TEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTR 250 TEF LRP AQALE GPP RR+ GI+GRT+++WLLGSGVP++GI+L A FE+ LL+LT Sbjct 191 TEFWLRPMTAQALETGPPHRRIGSGIIGRTLLIWLLGSGVPLIGISLFAAFEVALLHLTV 250 Query 251 MQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTEL 310 ++FA GV+I S TLVFG +L+ I AWLTATPVR+VRAAL++VE+G+LR ++VVFDG+EL Sbjct 251 VEFAVGVMIASSATLVFGLLLIAISAWLTATPVRLVRAALKQVEQGDLRGDVVVFDGSEL 310 Query 311 GELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGS 370 GELQ GFN+MV GLRERERVRDLFGRHVGREVAAAAER+ +LGGEER+VAVVF+DI+GS Sbjct 311 GELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAAERKPPQLGGEERYVAVVFVDIIGS 370 Query 371 TQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKAL 430 TQLV++RP DVV+LLN+FFA++VDEV+RH GLVNKFEGDASL IFGAPN L CPE AL Sbjct 371 TQLVSNRPATDVVQLLNRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPNPLECPEVAAL 430 Query 431 AAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKS 490 +AARAIA RL E+PEC+AGIGVAAGQV+AGNVGA ERFEYTVIG PVNEAARLCELAKS Sbjct 431 SAARAIAGRLCTEVPECRAGIGVAAGQVVAGNVGANERFEYTVIGGPVNEAARLCELAKS 490 Query 491 RPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKP 533 +L+AS++ V A+E ERA W+L V LRG D+P LA P Sbjct 491 YSARLVASSETVAGATETERAHWNLAETVTLRGRDRPTHLAIP 533 >gi|289761474|ref|ZP_06520852.1| adenylate cyclase [Mycobacterium tuberculosis GM 1503] gi|289708980|gb|EFD72996.1| adenylate cyclase [Mycobacterium tuberculosis GM 1503] Length=446 Score = 615 bits (1586), Expect = 6e-174, Method: Compositional matrix adjust. Identities = 315/441 (72%), Positives = 368/441 (84%), Gaps = 1/441 (0%) Query 94 VVPGYVLLALALGSYALTRQTVQA-LRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGV 152 V P Y LALA+G+Y +T + V+A +RWAIE R P++ + R T L P+RVA HL+ W + Sbjct 5 VAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDI 64 Query 153 GTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRL 212 G ALL TLYGL N F+ LF+V+ CGVLVAT YL TEFALRP AA+ALEAG PPRR Sbjct 65 GGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRF 124 Query 213 APGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILM 272 APGI+GRTM VW LGSGVPV GIA A++ +++ NLT Q A+ VLI+S+ TL+FGF++M Sbjct 125 APGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVM 184 Query 273 WILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRD 332 WILAWLTA PVRVVRAAL+RVE+G+LR +LVVFDGTELGELQRGFNAMV GLRERERVRD Sbjct 185 WILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRD 244 Query 333 LFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAI 392 LFGRHVGREVAAAAERER +LGGE+RH AVVF+DIVGSTQLV ++P A VVKLLN+FFAI Sbjct 245 LFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAI 304 Query 393 VVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIG 452 VV+EVDRHHGL+NKF GDA+L IFGAPNRL PED ALAAARAIA+RL NEMPE QAGIG Sbjct 305 VVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIAERLANEMPEVQAGIG 364 Query 453 VAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERAR 512 VAAGQ++AGNVGA++RFEYTV+G+PVN+AARLCELAKS P +LLAS+ + AASE ERA Sbjct 365 VAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAH 424 Query 513 WSLGRHVKLRGHDQPVRLAKP 533 WSLG V LRGH+QP RLA P Sbjct 425 WSLGETVTLRGHEQPTRLAVP 445 >gi|306792738|ref|ZP_07431040.1| putative HAMP domain protein [Mycobacterium tuberculosis SUMu005] gi|308338807|gb|EFP27658.1| putative HAMP domain protein [Mycobacterium tuberculosis SUMu005] Length=435 Score = 606 bits (1563), Expect = 3e-171, Method: Compositional matrix adjust. Identities = 305/435 (71%), Positives = 357/435 (83%), Gaps = 1/435 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAAR 434 NRL PED ALAAAR Sbjct 421 NRLDRPEDAALAAAR 435 >gi|306784048|ref|ZP_07422370.1| adenylate cyclase [Mycobacterium tuberculosis SUMu003] gi|308331184|gb|EFP20035.1| adenylate cyclase [Mycobacterium tuberculosis SUMu003] Length=448 Score = 600 bits (1548), Expect = 1e-169, Method: Compositional matrix adjust. Identities = 316/447 (71%), Positives = 368/447 (83%), Gaps = 1/447 (0%) Query 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 M AKK+ AQRLG+ LET+TRQ G+LPETPAYGSWLLGRVSES RR VRI+ ++T ++T Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQA-LR 119 ANL GI VALL+VT A P PSI D P W+TFGV P Y LALA+G+Y +T + V+A +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFC 179 WAIE R P++ + R T L P+RVA HL+ W +G ALL TLYGL N F+ LF+V+ C Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 239 GVLVAT YL TEFALRP AA+ALEAG PPRR APGI+GRTM VW LGSGVPV GIA A Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 299 ++ +++ NLT Q A+ VLI+S+ TL+FGF++MWILAWLTA PVRVVRAAL+RVE+G+LR Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 359 +LVVFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 419 AVVF+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLPCPEDKALAAARAIADRLVNEMPE 446 NRL PED ALAAARAIADRL NEMPE Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPE 447 >gi|306784046|ref|ZP_07422368.1| putative HAMP domain protein [Mycobacterium tuberculosis SUMu003] gi|308331190|gb|EFP20041.1| putative HAMP domain protein [Mycobacterium tuberculosis SUMu003] Length=433 Score = 597 bits (1539), Expect = 2e-168, Method: Compositional matrix adjust. Identities = 301/430 (70%), Positives = 349/430 (82%), Gaps = 0/430 (0%) Query 4 KKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANL 63 K+ QRL RVLET+TRQ RL + PAYGSWLLG VSE RRRVRIQ++LT ++TANL Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 LGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIE 123 +GIG+A+LL +A P PSIV D P W+TF P Y ++ +ALGSY + QT+ ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 GRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLV 183 P+R ++R T LAP RVAVG L+ W VG AL TTLYGL N FIP+ +F+ FCGVLV Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEM 243 ATA Y+ TEFALRP AAQALEAG PP R A GI+GRTMVVWLL SGVP+ GIAL+ + EM Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 VLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLV 303 VL N T +QFA GVLI+S TL+ GF+LMWI++WLTA PVRVVRAAL+RVE+G+LR +LV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVV 363 VFDGTELGELQRGFNAMV GLRERERVRDLFGRHVGREVAAAAERER +LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLP 423 F+DIVGSTQLV ++P A VVKLLN+FFAIVV+EVDRHHGL+NKF GDA+L IFGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 CPEDKALAAA 433 PED ALAAA Sbjct 422 RPEDAALAAA 431 Lambda K H 0.324 0.138 0.410 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1192584998088 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40