BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1320c Length=567 Score E Sequences producing significant alignments: (Bits) Value gi|15608460|ref|NP_215836.1| adenylate cyclase [Mycobacterium tu... 1140 0.0 gi|15840773|ref|NP_335810.1| adenylate cyclase, putative [Mycoba... 1139 0.0 gi|289446916|ref|ZP_06436660.1| adenylate cyclase [Mycobacterium... 1137 0.0 gi|339631388|ref|YP_004723030.1| adenylate cyclase [Mycobacteriu... 1136 0.0 gi|340626336|ref|YP_004744788.1| putative adenylate cyclase [Myc... 1135 0.0 gi|308399382|ref|ZP_07492998.2| adenylate cyclase [Mycobacterium... 1051 0.0 gi|339294302|gb|AEJ46413.1| adenylate cyclase, putative [Mycobac... 1050 0.0 gi|240169496|ref|ZP_04748155.1| putative adenylate cyclase [Myco... 775 0.0 gi|240169497|ref|ZP_04748156.1| adenylate cyclase [Mycobacterium... 717 0.0 gi|183984049|ref|YP_001852340.1| adenylate cyclase [Mycobacteriu... 714 0.0 gi|296170261|ref|ZP_06851852.1| adenylate cyclase [Mycobacterium... 704 0.0 gi|15608458|ref|NP_215834.1| adenylate cyclase [Mycobacterium tu... 699 0.0 gi|339631385|ref|YP_004723027.1| adenylate cyclase [Mycobacteriu... 698 0.0 gi|148822536|ref|YP_001287290.1| adenylate cyclase [Mycobacteriu... 696 0.0 gi|340626333|ref|YP_004744785.1| putative adenylate cyclase [Myc... 696 0.0 gi|342858019|ref|ZP_08714675.1| hypothetical protein MCOL_04055 ... 685 0.0 gi|41408538|ref|NP_961374.1| hypothetical protein MAP2440 [Mycob... 684 0.0 gi|253799635|ref|YP_003032636.1| adenylate cyclase [Mycobacteriu... 684 0.0 gi|333989962|ref|YP_004522576.1| adenylate cyclase [Mycobacteriu... 683 0.0 gi|118465998|ref|YP_880776.1| HAMP domain-containing protein [My... 682 0.0 gi|254821322|ref|ZP_05226323.1| hypothetical protein MintA_15392... 682 0.0 gi|148822541|ref|YP_001287295.1| adenylate cyclase [Mycobacteriu... 681 0.0 gi|15608459|ref|NP_215835.1| adenylate cyclase [Mycobacterium tu... 681 0.0 gi|289442759|ref|ZP_06432503.1| adenylate cyclase [Mycobacterium... 679 0.0 gi|339631387|ref|YP_004723029.1| adenylate cyclase [Mycobacteriu... 679 0.0 gi|15840772|ref|NP_335809.1| adenylate cyclase, putative [Mycoba... 677 0.0 gi|289745069|ref|ZP_06504447.1| adenylate cyclase [Mycobacterium... 674 0.0 gi|326902942|gb|EGE49875.1| LOW QUALITY PROTEIN: adenylate cycla... 672 0.0 gi|183984050|ref|YP_001852341.1| adenylate cyclase [Mycobacteriu... 672 0.0 gi|289446915|ref|ZP_06436659.1| adenylate cyclase, putative [Myc... 671 0.0 gi|298524825|ref|ZP_07012234.1| conserved hypothetical protein [... 671 0.0 gi|254364216|ref|ZP_04980262.1| hypothetical adenylate cyclase (... 670 0.0 gi|298524824|ref|ZP_07012233.1| adenylate cyclase [Mycobacterium... 668 0.0 gi|340626334|ref|YP_004744786.1| adenylate cyclase [Mycobacteriu... 667 0.0 gi|289757423|ref|ZP_06516801.1| adenylate cyclase [Mycobacterium... 666 0.0 gi|15840771|ref|NP_335808.1| adenylate cyclase, putative [Mycoba... 665 0.0 gi|183984051|ref|YP_001852342.1| adenylate cyclase [Mycobacteriu... 655 0.0 gi|120405263|ref|YP_955092.1| putative adenylate/guanylate cycla... 652 0.0 gi|118619189|ref|YP_907521.1| adenylate cyclase [Mycobacterium u... 648 0.0 gi|183984091|ref|YP_001852382.1| adenylate cyclase [Mycobacteriu... 647 0.0 gi|118619151|ref|YP_907483.1| adenylate cyclase [Mycobacterium u... 646 0.0 gi|145222924|ref|YP_001133602.1| putative adenylate/guanylate cy... 643 0.0 gi|289573983|ref|ZP_06454210.1| conserved hypothetical protein [... 641 0.0 gi|108800832|ref|YP_641029.1| adenylate/guanylate cyclase [Mycob... 636 3e-180 gi|118473953|ref|YP_889179.1| adenylate cyclase, family protein ... 623 3e-176 gi|183983769|ref|YP_001852060.1| adenylate cyclase [Mycobacteriu... 611 1e-172 gi|289761474|ref|ZP_06520852.1| adenylate cyclase [Mycobacterium... 583 2e-164 gi|169628550|ref|YP_001702199.1| hypothetical protein MAB_1459c ... 562 5e-158 gi|306792738|ref|ZP_07431040.1| putative HAMP domain protein [My... 548 8e-154 gi|306775497|ref|ZP_07413834.1| adenylate cyclase [Mycobacterium... 541 1e-151 >gi|15608460|ref|NP_215836.1| adenylate cyclase [Mycobacterium tuberculosis H37Rv] gi|148661108|ref|YP_001282631.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] gi|167967592|ref|ZP_02549869.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] gi|1722970|sp|Q10633.1|Y1320_MYCTU RecName: Full=Uncharacterized protein Rv1320c/MT1362 gi|1340086|emb|CAA98107.1| POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE) [Mycobacterium tuberculosis H37Rv] gi|148505260|gb|ABQ73069.1| putative adenylate cyclase [Mycobacterium tuberculosis H37Ra] Length=567 Score = 1140 bits (2950), Expect = 0.0, Method: Compositional matrix adjust. Identities = 567/567 (100%), Positives = 567/567 (100%), Gaps = 0/567 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 Query 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 AQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 >gi|15840773|ref|NP_335810.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|31792515|ref|NP_855008.1| adenylate cyclase [Mycobacterium bovis AF2122/97] gi|121637250|ref|YP_977473.1| putative adenylate cyclase [Mycobacterium bovis BCG str. Pasteur 1173P2] 64 more sequence titles Length=567 Score = 1139 bits (2945), Expect = 0.0, Method: Compositional matrix adjust. Identities = 566/567 (99%), Positives = 566/567 (99%), Gaps = 0/567 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRL SPVQQLQMP Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPVQQLQMP 540 Query 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 AQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 >gi|289446916|ref|ZP_06436660.1| adenylate cyclase [Mycobacterium tuberculosis CPHL_A] gi|289419874|gb|EFD17075.1| adenylate cyclase [Mycobacterium tuberculosis CPHL_A] Length=567 Score = 1137 bits (2941), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/567 (99%), Positives = 565/567 (99%), Gaps = 0/567 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASL VFGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLTVFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRL SPVQQLQMP Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPVQQLQMP 540 Query 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 AQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 >gi|339631388|ref|YP_004723030.1| adenylate cyclase [Mycobacterium africanum GM041182] gi|339330744|emb|CCC26415.1| putative adenylate cyclase (ATP pyrophosphate-lyase) [Mycobacterium africanum GM041182] Length=567 Score = 1136 bits (2938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/567 (99%), Positives = 565/567 (99%), Gaps = 0/567 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV Sbjct 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TNVIGLIVGAMLLTVAFPK SVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKSSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRL SPVQQLQMP Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPVQQLQMP 540 Query 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 AQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 >gi|340626336|ref|YP_004744788.1| putative adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|340004526|emb|CCC43669.1| putative adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium canettii CIPT 140010059] Length=567 Score = 1135 bits (2937), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/567 (99%), Positives = 565/567 (99%), Gaps = 0/567 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M SEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV Sbjct 1 MQSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW Sbjct 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG Sbjct 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI Sbjct 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG Sbjct 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN Sbjct 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE Sbjct 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRL SPVQQLQMP Sbjct 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPVQQLQMP 540 Query 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 AQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 541 AQSADIVGGALGDHQTHTIYRGAHPTD 567 >gi|308399382|ref|ZP_07492998.2| adenylate cyclase [Mycobacterium tuberculosis SUMu012] gi|308366468|gb|EFP55319.1| adenylate cyclase [Mycobacterium tuberculosis SUMu012] Length=523 Score = 1051 bits (2719), Expect = 0.0, Method: Compositional matrix adjust. Identities = 523/523 (100%), Positives = 523/523 (100%), Gaps = 0/523 (0%) Query 45 MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI 104 MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI Sbjct 1 MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI 60 Query 105 LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLA 164 LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLA Sbjct 61 LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLA 120 Query 165 NRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVW 224 NRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVW Sbjct 121 NRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVW 180 Query 225 LLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVR 284 LLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVR Sbjct 181 LLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVR 240 Query 285 VVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAA 344 VVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAA Sbjct 241 VVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAA 300 Query 345 AAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLV 404 AAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLV Sbjct 301 AAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLV 360 Query 405 NKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVG 464 NKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVG Sbjct 361 NKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVG 420 Query 465 AHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGH 524 AHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGH Sbjct 421 AHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGH 480 Query 525 DQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD 567 DQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 481 DQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD 523 >gi|339294302|gb|AEJ46413.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5079] gi|339297941|gb|AEJ50051.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5180] Length=523 Score = 1050 bits (2715), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/523 (99%), Positives = 522/523 (99%), Gaps = 0/523 (0%) Query 45 MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI 104 MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI Sbjct 1 MRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFI 60 Query 105 LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLA 164 LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLA Sbjct 61 LGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLA 120 Query 165 NRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVW 224 NRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVW Sbjct 121 NRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVW 180 Query 225 LLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVR 284 LLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVR Sbjct 181 LLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVR 240 Query 285 VVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAA 344 VVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAA Sbjct 241 VVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAA 300 Query 345 AAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLV 404 AAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLV Sbjct 301 AAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLV 360 Query 405 NKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVG 464 NKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVG Sbjct 361 NKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVG 420 Query 465 AHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGH 524 AHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGH Sbjct 421 AHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGH 480 Query 525 DQPIRLTSPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD 567 DQPIRL SPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD Sbjct 481 DQPIRLASPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD 523 >gi|240169496|ref|ZP_04748155.1| putative adenylate cyclase [Mycobacterium kansasii ATCC 12478] Length=537 Score = 775 bits (2001), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/536 (73%), Positives = 460/536 (86%), Gaps = 2/536 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRP-ETPAYGSWLLGRVSESPRMRRVRIQGMLTVAIL 59 M S+KA + L ++ ++ R R P ETPAYGSWLLGR SES + +R+RIQ M++V IL Sbjct 1 MSSQKAVAQRLDRVLDKVA-RWFRWPSETPAYGSWLLGRASESQQRQRIRIQVMMSVTIL 59 Query 60 VTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALR 119 ++G+ + A+LLTVAFPKPSVI DAP W+SFG+VP Y VLA +LG WLTRQT RALR Sbjct 60 AAQLVGITIAALLLTVAFPKPSVIFDAPRWLSFGLVPAYNVLAVVLGALWLTRQTTRALR 119 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEERTP+ DEAR F +P RV+LAVLF+WG ALWT +YG+AN +FIPRFLFSM V+ Sbjct 120 WAIEERTPTPDEARDTFRIPARVSLAVLFVWGFGMALWTTLYGMANPVFIPRFLFSMSVV 179 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ ATS YLL+EFALRP+AA+ALEVG T RSLV GI+ RTM+VWLLCSG+PN+G+ALTA Sbjct 180 GVLVATSSYLLSEFALRPVAARALEVGPTSRSLVPGIMSRTMVVWLLCSGLPNIGIALTA 239 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 +F++TFWEL NDQ++++VLILW P+++FGF+LMW+LAW+TATPV VVR AL RVEQGDL+ Sbjct 240 LFENTFWELENDQYIVSVLILWTPVMVFGFVLMWMLAWMTATPVGVVRAALKRVEQGDLA 299 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFD TELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAER+ PKLGGEERH Sbjct 300 GDLVVFDATELGELQRGFNAMVHGLRERERVRDLFGRHVGREVALAAERQPPKLGGEERH 359 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 VAVVF+DIVGST+LVTS+P A+VV LLNRFF V++DE++ HRGLVNKFQGDASLA+FGAP Sbjct 360 VAVVFIDIVGSTKLVTSQPPADVVQLLNRFFAVVIDEIDRHRGLVNKFQGDASLAIFGAP 419 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 N L PED ALA ARAIA+RLA+E+PEC AGIGVA+GQVVAGNVGA+ERFEYTVIGEPVN Sbjct 420 NHLDRPEDQALAAARAIAERLANEVPECPAGIGVASGQVVAGNVGANERFEYTVIGEPVN 479 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQ 535 +AARLCELAKS+P +LLA++ T+RGA+E+E A WSLGE VTLRGHDQ RL SPVQ Sbjct 480 QAARLCELAKSHPGQLLATADTVRGATEHESALWSLGEVVTLRGHDQQTRLASPVQ 535 >gi|240169497|ref|ZP_04748156.1| adenylate cyclase [Mycobacterium kansasii ATCC 12478] Length=541 Score = 717 bits (1851), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/535 (69%), Positives = 427/535 (80%), Gaps = 0/535 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M +E++ + L +ET++ ++GR ETPAYGSWLLGRVSE R RR+RIQ +LTV ++ Sbjct 1 MVAEESMAQRLGRVLETVTRQSGRLSETPAYGSWLLGRVSEDQRRRRIRIQVILTVMVVA 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 NVIG+ V +L+TVA P+PSV DAP WVSF +VP Y V+A LG YW+TR+T ALRW Sbjct 61 ANVIGIAVSILLVTVAIPEPSVFSDAPLWVSFAVVPAYIVVALALGAYWITRRTVIALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEER P+HD+ R+ FL P RVA+ L LWG AAL T +YG+AN +FIPRFLF++ G Sbjct 121 AIEERPPTHDDERNTFLTPWRVAIVDLILWGVGAALLTTLYGMANTMFIPRFLFAVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 ++ AT YLLTEFALRP+AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL AI Sbjct 181 LLVATGSYLLTEFALRPVAAQALEAGPPPRRLASGIMGRTMMVWLLGSGVPIVGIALIAI 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F L+ QF + VLI+ L+FGF+LMWILAWLTATPVRVVR AL RVE+GDL G Sbjct 241 FQIGMRNLTATQFAVGVLIVSMATLVFGFVLMWILAWLTATPVRVVRAALQRVERGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVHGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGST+LVTS+P AEVV LLNRFF ++V+EV+ H GLVNKF+GDASLA+FGAPN Sbjct 361 AVVFLDIVGSTKLVTSQPPAEVVQLLNRFFAIVVEEVDRHYGLVNKFEGDASLAIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L PED ALA AR +A RLA EM ECQAGIGVA+GQVVAGNVG+ ERFEYTVIGEPVNE Sbjct 421 HLDQPEDQALACARTLAQRLAEEMRECQAGIGVASGQVVAGNVGSKERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQ 535 AARLCE AKS P +LLAS+QT+ ASE+E A W+LG V LRGH QP RL SP++ Sbjct 481 AARLCERAKSRPGKLLASAQTVEAASESERAHWTLGRHVKLRGHKQPTRLASPIE 535 >gi|183984049|ref|YP_001852340.1| adenylate cyclase [Mycobacterium marinum M] gi|183177375|gb|ACC42485.1| adenylate cyclase [Mycobacterium marinum M] Length=550 Score = 714 bits (1842), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/520 (71%), Positives = 424/520 (82%), Gaps = 0/520 (0%) Query 15 VETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLT 74 +E ++ ++GR PETPAYGSWLLGRVSES + RR+RIQ +LTV ++V N++G+ V +L+T Sbjct 31 LERVTRQSGRLPETPAYGSWLLGRVSESQQRRRIRIQTILTVMVVVANLLGIAVSILLVT 90 Query 75 VAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARS 134 VA P PSV +AP W++F +VP Y V+A LGTYW+TR+T ALRWAIEER P+ ++ R+ Sbjct 91 VAIPSPSVFTEAPWWITFVVVPSYIVVALALGTYWITRRTVLALRWAIEERQPTPEDERN 150 Query 135 AFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFA 194 FL RVA+ L LWG+ A L T +YG+AN +FIPRFLF++ GV+ AT YLLTEFA Sbjct 151 TFLAAWRVAVVDLILWGSGAVLLTTLYGMANTMFIPRFLFAVTFCGVLVATGSYLLTEFA 210 Query 195 LRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFM 254 LRP+AAQAL G PR L GI+GRTM+VWLL SGVP VG+AL AIF LS QF Sbjct 211 LRPVAAQALAAGPPPRRLSSGIMGRTMMVWLLGSGVPVVGIALVAIFQIALRNLSETQFA 270 Query 255 ITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQ 314 + VLI+ LIFGFILMWI++WLTATPVRVVR ALNRV GDL GDLVVFDGTELGELQ Sbjct 271 VGVLIVSMATLIFGFILMWIMSWLTATPVRVVRAALNRVANGDLRGDLVVFDGTELGELQ 330 Query 315 RGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLV 374 RGFN MV+GLRERERVRDLFGRHVGREVA AAERERPKLGGEERHVAVVF+DIVGST+LV Sbjct 331 RGFNTMVDGLRERERVRDLFGRHVGREVAIAAERERPKLGGEERHVAVVFIDIVGSTKLV 390 Query 375 TSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATAR 434 TS+P A+VV LLNRFF V+VDEV+ HRGLVNKF+GDASLA+FGAPN L PED ALA AR Sbjct 391 TSQPPADVVALLNRFFAVVVDEVDRHRGLVNKFEGDASLAIFGAPNHLERPEDQALAAAR 450 Query 435 AIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSR 494 IA RLASE+PECQAGIGVAAGQVVAGNVG+ ERFEYTVIGEPVNEAARLCELAK +P R Sbjct 451 TIAARLASEVPECQAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNEAARLCELAKDHPGR 510 Query 495 LLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 LLAS L GAS +E ARWS+G+TVTLRGHDQP RL +P+ Sbjct 511 LLASGAALDGASHDERARWSVGKTVTLRGHDQPTRLAAPI 550 >gi|296170261|ref|ZP_06851852.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894984|gb|EFG74703.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=544 Score = 704 bits (1818), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/542 (65%), Positives = 425/542 (79%), Gaps = 0/542 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + ++ + + +ET++ ++GR PETPAYGS LLGRV+ES + RR+RIQ +LTV +L Sbjct 1 MSANQSLAKRIGRVLETVTRQSGRLPETPAYGSLLLGRVTESQQRRRIRIQVILTVLVLG 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N+IG++V +L+TVA P+PSV DAP W++F P Y LA +GTYW+TR+T ALRW Sbjct 61 ANLIGIVVALLLVTVAIPQPSVFDDAPWWITFAASPAYIALALAVGTYWITRRTVLALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEER P+ ++ R+ FL P R+A L LWG A + T +YGL N LFIPRFL ++G+ G Sbjct 121 AIEERAPTEEDERNTFLAPWRIARFDLILWGVGAVVLTTLYGLVNTLFIPRFLIAVGICG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 ++ AT YLL EFALRP AAQALE G PR GI+GRTM+VW L SG+P +G+A A Sbjct 181 ILVATGSYLLAEFALRPAAAQALEAGPPPRRFASGIMGRTMVVWFLGSGLPVLGIAFLAG 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F L+ QF + VL++ + FG +LMWILAWLTATPVRVVR AL RVE+GDL G Sbjct 241 FQALMRNLTETQFAVGVLMVSIATVTFGCLLMWILAWLTATPVRVVRAALRRVERGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFN MV+GLRERERVRDLFGRHVGREVA AAERE+PKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAEREKPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGST+LVTSRPAAE+V LLNRFF ++V+EV+ H GLVNKF+GDA+LAVFGAPN Sbjct 361 AVVFIDIVGSTKLVTSRPAAEIVQLLNRFFAIVVEEVDRHCGLVNKFEGDATLAVFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RL PE+ ALA AR+IA RL SE+ ECQAGIGVAAGQVVAGNVGA ERFEYTVIG PVNE Sbjct 421 RLDRPEEQALAAARSIAGRLDSEIAECQAGIGVAAGQVVAGNVGARERFEYTVIGGPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 A+RLCELAKS+P RLLA++ L GAS+ E ARWSLG+TVTLRGH++P RL SP + + Sbjct 481 ASRLCELAKSHPGRLLATADALEGASDTERARWSLGDTVTLRGHERPTRLASPAEPVDAS 540 Query 541 AQ 542 A+ Sbjct 541 AR 542 >gi|15608458|ref|NP_215834.1| adenylate cyclase [Mycobacterium tuberculosis H37Rv] gi|15840770|ref|NP_335807.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|31792513|ref|NP_855006.1| adenylate cyclase [Mycobacterium bovis AF2122/97] 60 more sequence titles Length=541 Score = 699 bits (1803), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/534 (69%), Positives = 426/534 (80%), Gaps = 0/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RL PV Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 >gi|339631385|ref|YP_004723027.1| adenylate cyclase [Mycobacterium africanum GM041182] gi|339330741|emb|CCC26412.1| putative adenylate cyclase (ATP pyrophosphate-lyase) [Mycobacterium africanum GM041182] Length=541 Score = 698 bits (1802), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/534 (69%), Positives = 426/534 (80%), Gaps = 0/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEGRKPAREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RL PV Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 >gi|148822536|ref|YP_001287290.1| adenylate cyclase [Mycobacterium tuberculosis F11] gi|253799636|ref|YP_003032637.1| adenylate cyclase [Mycobacterium tuberculosis KZN 1435] gi|254550326|ref|ZP_05140773.1| adenylate cyclase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] 11 more sequence titles Length=541 Score = 696 bits (1797), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/534 (69%), Positives = 425/534 (80%), Gaps = 0/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ QF VLI+ L+ GFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVLGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RL PV Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 >gi|340626333|ref|YP_004744785.1| putative adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|340004523|emb|CCC43666.1| putative adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium canettii CIPT 140010059] Length=541 Score = 696 bits (1796), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/534 (69%), Positives = 426/534 (80%), Gaps = 0/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA +G+Y LTRQT +ALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALAVGSYALTRQTVQALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIE R P+ ++ R FL P RVA+ L WG AL T +YGL N FIPRFLF++ G Sbjct 121 AIEGRKPTREDERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A+ Sbjct 181 VLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAM 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 241 FEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRT 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERHV Sbjct 301 NLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAPN Sbjct 361 AVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVNE Sbjct 421 RLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 AARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RL PV Sbjct 481 AARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 534 >gi|342858019|ref|ZP_08714675.1| hypothetical protein MCOL_04055 [Mycobacterium colombiense CECT 3035] gi|342135352|gb|EGT88518.1| hypothetical protein MCOL_04055 [Mycobacterium colombiense CECT 3035] Length=539 Score = 685 bits (1768), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/537 (66%), Positives = 420/537 (79%), Gaps = 0/537 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M ++ + + +E ++ ++GR PETPAYGS LLGRVSES RR+RIQ ++TV +L Sbjct 1 MSPNQSVAQRIGRVLERVTRQSGRLPETPAYGSLLLGRVSESQGRRRIRIQIIMTVLVLG 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++G+ G +L+ VA P PS+ DAP W++FG+ P Y VLA +GT W+TR+T ALRW Sbjct 61 ANLLGIGAGLILVIVAIPVPSIFDDAPAWLTFGVAPAYIVLALTVGTVWITRRTVLALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEERTP+ ++ R+ F+ P R+AL L LWG A L+T++YGL N +FIPRFL + G Sbjct 121 AIEERTPTPEDERNTFIAPWRIALVDLVLWGTGALLYTVLYGLVNTMFIPRFLVGVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT YLL E +LRP+AAQALE G PR L GI+GRTM+VW L SGVP +G+AL + Sbjct 181 VLVATGSYLLAELSLRPVAAQALEAGPPPRRLAAGIMGRTMMVWFLGSGVPIIGIALLTL 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ QF + VLI+ + LIFG +LMWILAWLTATPVRVVR AL RVE+GDL G Sbjct 241 FEIWLRNLTQTQFAVGVLIVSSAALIFGCMLMWILAWLTATPVRVVRAALQRVEEGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFN MV+GLRERERVRDLFGRHVGREVA AAERE PKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAEREMPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVT+RP AEVV +LN+FF ++V+EV+ H GLVNKF+GDASLA+FGAPN Sbjct 361 AVVFIDIVGSTQLVTNRPPAEVVSVLNQFFAIVVEEVDRHHGLVNKFEGDASLAIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 RL PED ALA AR I RLA+EM E AGIGVAAGQ VAGNVGA ERFEYTVIGEPVNE Sbjct 421 RLDSPEDEALAAARCITGRLANEMSELSAGIGVAAGQAVAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQL 537 AARLCELAKS+ SRLLA++ + ASENE RWSLG+TVTLRGH++P RL SPV QL Sbjct 481 AARLCELAKSHSSRLLATADAVERASENERERWSLGDTVTLRGHERPTRLASPVDQL 537 >gi|41408538|ref|NP_961374.1| hypothetical protein MAP2440 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396896|gb|AAS04757.1| hypothetical protein MAP_2440 [Mycobacterium avium subsp. paratuberculosis K-10] gi|336460972|gb|EGO39853.1| family 3 adenylate cyclase [Mycobacterium avium subsp. paratuberculosis S397] Length=544 Score = 684 bits (1765), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/543 (66%), Positives = 426/543 (79%), Gaps = 0/543 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + ++T + + +E ++ ++GR PETPAYGS LLGRV+ES RR+RIQ ++TV +L Sbjct 1 MSATQSTAQRIGRVLEKITRQSGRLPETPAYGSLLLGRVTESQHRRRIRIQIIMTVMVLG 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N+IG+ +L+ VA P PSV DAP W++FG+ P Y A +GTYW+TR+T ALRW Sbjct 61 ANLIGIGAALILVIVAIPAPSVFNDAPAWITFGVGPAYVASALAVGTYWITRRTVLALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEER P+ + R+ FL P R+AL L LWGA L T++YGL + +FIPRFLF + G Sbjct 121 AIEERKPTPTDERNTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT+CYLL EFALRP+AAQALE G PR L GI+GRTM VW L SGVP +G+AL A+ Sbjct 181 VLVATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVIGIALLAL 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ +F + VLI+ LIFG +LMWILAWLTATPVRVVR AL RVE+GDL G Sbjct 241 FEIWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFN MV+GLRERERVRDLFGRHVGREVA AAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVT RP AEVV +LN+FF ++V+EV+ H GLVNKF+GDA+LA+FGAPN Sbjct 361 AVVFIDIVGSTQLVTRRPPAEVVSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L PEDAAL ARAIADRLA+EMP+C+AGIGVAAGQVVAGNVGA ERFEYTVIGEPVNE Sbjct 421 HLDCPEDAALTAARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKS+ SRLLA+ + GASE E ARWSLG+TVTLRGH++P RL SP P Sbjct 481 AARLCELAKSHSSRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLASPAGAADRP 540 Query 541 AQS 543 A + Sbjct 541 AGT 543 >gi|253799635|ref|YP_003032636.1| adenylate cyclase [Mycobacterium tuberculosis KZN 1435] gi|254231573|ref|ZP_04924900.1| hypothetical protein TBCG_01300 [Mycobacterium tuberculosis C] gi|289442760|ref|ZP_06432504.1| adenylate cyclase [Mycobacterium tuberculosis T46] 16 more sequence titles Length=535 Score = 684 bits (1764), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/534 (67%), Positives = 418/534 (79%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIA+RLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRGH+QP RL P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 534 >gi|333989962|ref|YP_004522576.1| adenylate cyclase [Mycobacterium sp. JDM601] gi|333485930|gb|AEF35322.1| adenylate cyclase [Mycobacterium sp. JDM601] Length=524 Score = 683 bits (1762), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/520 (67%), Positives = 411/520 (80%), Gaps = 0/520 (0%) Query 15 VETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLT 74 +E L+ +T R PETP YGSWLLGRVSES +RR+RIQ +LTV I+ TN+IG+ V A+LL Sbjct 5 LELLTRQTDRLPETPEYGSWLLGRVSESQYLRRIRIQFILTVVIVGTNLIGIGVEALLLA 64 Query 75 VAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARS 134 VAFP PSV DAP W+++G+VP Y VLA I GTYW+TR+T + LRWAI E+ P+ + R+ Sbjct 65 VAFPSPSVFFDAPGWLTYGVVPAYIVLALIFGTYWITRRTIKKLRWAIREQQPTRVDERN 124 Query 135 AFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFA 194 AFL P RVA VL LWG AA L+T++YG+A+ FIP F++GV G+ AT+CYL TEFA Sbjct 125 AFLAPWRVAQVVLALWGVAAMLFTVLYGMADNYFIPIVAFTVGVCGIQVATACYLCTEFA 184 Query 195 LRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFM 254 LRP+AAQAL G PR GI+GRTM+VWLL SGVP +G+ALTAIF LS QF Sbjct 185 LRPVAAQALAAGPPPRRFFSGIMGRTMMVWLLSSGVPVLGIALTAIFALVLKNLSMTQFG 244 Query 255 ITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQ 314 + VL++ +FGF+LMWIL+WLTA PVRVVR AL RVEQG+L DLVVFDGTELGELQ Sbjct 245 VAVLVVAVATAVFGFLLMWILSWLTAAPVRVVRAALRRVEQGNLGADLVVFDGTELGELQ 304 Query 315 RGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLV 374 GFN MV GLRERERVRDLFGRHVGREVAAAAER+R +LGGEERHVAV+FVDI+GSTQ+V Sbjct 305 SGFNAMVHGLRERERVRDLFGRHVGREVAAAAERDRIQLGGEERHVAVLFVDIIGSTQIV 364 Query 375 TSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATAR 434 T++PA EVV LLNRFF V+VDEV+ HRGL+NKF+GDASLA+FGAPN L PED ALA R Sbjct 365 TAKPATEVVTLLNRFFAVVVDEVDRHRGLINKFEGDASLAIFGAPNHLDQPEDEALAAGR 424 Query 435 AIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSR 494 AI RLA E+PE +AGIGVAAGQVVAGNVGA ERFEYTVIGEPVNEAARL ELAK + Sbjct 425 AILSRLADEVPEIRAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAARLSELAKIRELQ 484 Query 495 LLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 LL +++TLR AS +E A W LG++V LRG+DQP L P+ Sbjct 485 LLTTARTLRAASISEQAHWVLGDSVVLRGYDQPTVLAGPL 524 >gi|118465998|ref|YP_880776.1| HAMP domain-containing protein [Mycobacterium avium 104] gi|254774360|ref|ZP_05215876.1| HAMP domain-containing protein [Mycobacterium avium subsp. avium ATCC 25291] gi|118167285|gb|ABK68182.1| hamp domain protein [Mycobacterium avium 104] Length=544 Score = 682 bits (1761), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/543 (66%), Positives = 425/543 (79%), Gaps = 0/543 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + ++T + + +E ++ ++GR PETPAYGS LLGRV+ES RR+RIQ ++TV +L Sbjct 1 MSATQSTAQRIGRVLEKITRQSGRLPETPAYGSLLLGRVTESQHRRRIRIQIIMTVMVLG 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N+IG+ +L+ VA P PSV DAP W++FG+ P Y A +GTYW+TR+T ALRW Sbjct 61 ANLIGIGAALILVIVAIPAPSVFNDAPAWITFGVGPAYVASALAVGTYWITRRTVLALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEER P+ + R+ FL P R+AL L LWGA L T++YGL + +FIPRFLF + G Sbjct 121 AIEERKPTPTDERNTFLAPWRIALVDLVLWGAGTLLLTVLYGLVDTMFIPRFLFGVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 V+ AT+CYLL EFALRP+AAQALE G PR L GI+GRTM VW L SGVP +G+AL A+ Sbjct 181 VLVATACYLLAEFALRPVAAQALEAGPPPRRLTAGIMGRTMTVWFLGSGVPVIGIALLAL 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ L+ +F + VLI+ LIFG +LMWILAWLTATPVRVVR AL RVE+GDL G Sbjct 241 FEIWLRNLTETEFAVGVLIVSTAALIFGCLLMWILAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 DLVVFDGTELGELQRGFN MV+GLRERERVRDLFGRHVGREVA AAERERPKLGGEERHV Sbjct 301 DLVVFDGTELGELQRGFNAMVDGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVF+DIVGSTQLVT RP AEVV +LN+FF ++V+EV+ H GLVNKF+GDA+LA+FGAPN Sbjct 361 AVVFIDIVGSTQLVTRRPPAEVVSVLNQFFGIVVEEVDRHCGLVNKFEGDATLAIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L PEDAAL ARAIADRLA+EMP+C+AGIGVAAGQVVAGNVGA ERFEYTVIGEPVNE Sbjct 421 HLDCPEDAALTAARAIADRLANEMPQCRAGIGVAAGQVVAGNVGARERFEYTVIGEPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP 540 AARLCELAKS+ RLLA+ + GASE E ARWSLG+TVTLRGH++P RL SP P Sbjct 481 AARLCELAKSHSGRLLATGDAIEGASEKERARWSLGDTVTLRGHERPTRLASPAGAADRP 540 Query 541 AQS 543 A + Sbjct 541 AGT 543 >gi|254821322|ref|ZP_05226323.1| hypothetical protein MintA_15392 [Mycobacterium intracellulare ATCC 13950] Length=528 Score = 682 bits (1760), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/521 (68%), Positives = 412/521 (80%), Gaps = 0/521 (0%) Query 15 VETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLT 74 +E ++ ++GR PETPAYGS LLGRVSES RRVRIQ ++TV +L N+IG+ V L+T Sbjct 2 LERVTRQSGRLPETPAYGSLLLGRVSESQGRRRVRIQIIMTVLVLGANLIGIAVALFLVT 61 Query 75 VAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARS 134 VA P PSV DAP W++FG P Y V A GTYW+TR+T ALRWAIEER P+ ++ R+ Sbjct 62 VAIPVPSVFDDAPAWITFGASPAYIVAASAWGTYWITRRTVIALRWAIEEREPTPEDERN 121 Query 135 AFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFA 194 F+ P R+AL L LWG L T +YG+ N LFIPRFL + GVV AT+ YLL EFA Sbjct 122 TFVAPWRIALVDLVLWGVGTILLTTLYGMVNTLFIPRFLLVVSFGGVVVATASYLLAEFA 181 Query 195 LRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFM 254 LRP+AAQALE G PR GI+GRTM+VW L S VP +G+ + A+F+ L+ QF Sbjct 182 LRPVAAQALEAGPPPRRFAAGIMGRTMVVWFLGSAVPVIGIMMLALFELVLRNLTQTQFA 241 Query 255 ITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQ 314 + VLI+ LIFG +LMWILAWLTATPVRVVR AL RVE+GDL GDLVVFDGTELGELQ Sbjct 242 VAVLIVSMAPLIFGCVLMWILAWLTATPVRVVRAALARVERGDLRGDLVVFDGTELGELQ 301 Query 315 RGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLV 374 RGFN MV+GLRERERVRDLFGRHVGREVA AAERERPKLGGEERHVAVVF+DIVGSTQLV Sbjct 302 RGFNTMVDGLRERERVRDLFGRHVGREVALAAERERPKLGGEERHVAVVFIDIVGSTQLV 361 Query 375 TSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATAR 434 TS+P AEVV +LNRFF ++V+EV+ + GLVNKF+GDA+LA+FGAPNRL PEDAALA AR Sbjct 362 TSQPPAEVVAVLNRFFAIVVEEVDRYCGLVNKFEGDATLAIFGAPNRLDSPEDAALAAAR 421 Query 435 AIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSR 494 IA+RLA EM + +AGIGVAAGQVVAGNVGA ERFEYTVIGEPVNEAARLCELAKS+ +R Sbjct 422 CIAERLADEMSDLEAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAARLCELAKSHTNR 481 Query 495 LLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQ 535 LLA++ + GASE+E ARWSLGETVTLRGH++P RL S V Sbjct 482 LLATADAIEGASEDERARWSLGETVTLRGHERPTRLASLVD 522 >gi|148822541|ref|YP_001287295.1| adenylate cyclase [Mycobacterium tuberculosis F11] gi|254364217|ref|ZP_04980263.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] gi|254550331|ref|ZP_05140778.1| adenylate cyclase, putative [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|134149731|gb|EBA41776.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] gi|148721068|gb|ABR05693.1| adenylate cyclase [Mycobacterium tuberculosis F11] Length=558 Score = 681 bits (1758), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/534 (66%), Positives = 418/534 (79%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIA+RLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|15608459|ref|NP_215835.1| adenylate cyclase [Mycobacterium tuberculosis H37Rv] gi|31792514|ref|NP_855007.1| adenylate cyclase [Mycobacterium bovis AF2122/97] gi|121637249|ref|YP_977472.1| putative adenylate cyclase [Mycobacterium bovis BCG str. Pasteur 1173P2] 13 more sequence titles Length=535 Score = 681 bits (1756), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/534 (67%), Positives = 418/534 (79%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRGH+QP RL P Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 534 >gi|289442759|ref|ZP_06432503.1| adenylate cyclase [Mycobacterium tuberculosis T46] gi|289415678|gb|EFD12918.1| adenylate cyclase [Mycobacterium tuberculosis T46] Length=540 Score = 679 bits (1751), Expect = 0.0, Method: Compositional matrix adjust. Identities = 364/535 (69%), Positives = 421/535 (79%), Gaps = 3/535 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M ++K+T + L +ET++ ++GR PETPAYGSWLLGRVSES R RRVRIQ MLT ++ Sbjct 1 MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++G+ V +L+T+A P+PS++ D P W++FG+VPGY +LA LG+Y LTRQT +ALRW Sbjct 61 ANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFI-PRFLFSMGVI 179 AIE R P+ +E R FL P RVA+ L WG AL T +YGL N FI R G Sbjct 121 AIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIIDRCSQQRG-- 178 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+ YL TEFALRP AAQALE G PR L GI+GRTM+VWLL SGVP VG+AL A Sbjct 179 GVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMA 238 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 +F+ L+ QF VLI+ L+FGFILMWILAWLTATPVRVVR AL RVE+G+L Sbjct 239 MFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELR 298 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERER KLGGEERH Sbjct 299 TNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERH 358 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 VAVVF+DIVGSTQLVTSRP A+VV LLN+FF ++VDEV+ H GLVNKF+GDASL +FGAP Sbjct 359 VAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAP 418 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PED ALA ARAIADRL +EMPECQAGIGVAAGQV+AGNVGA ERFEYTVIGEPVN Sbjct 419 NRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVN 478 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 EAARLCELAKS P +LLAS+Q + ASE E ARWSLG V LRGHDQP+RL PV Sbjct 479 EAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPV 533 >gi|339631387|ref|YP_004723029.1| adenylate cyclase [Mycobacterium africanum GM041182] gi|340626335|ref|YP_004744787.1| putative adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|339330743|emb|CCC26414.1| putative adenylate cyclase (ATP pyrophosphate-lyase) [Mycobacterium africanum GM041182] gi|340004525|emb|CCC43668.1| putative adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium canettii CIPT 140010059] Length=534 Score = 679 bits (1751), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/534 (67%), Positives = 418/534 (79%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|15840772|ref|NP_335809.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|289573984|ref|ZP_06454211.1| adenylate cyclase [Mycobacterium tuberculosis K85] gi|13880965|gb|AAK45623.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|289538415|gb|EFD42993.1| adenylate cyclase [Mycobacterium tuberculosis K85] Length=558 Score = 677 bits (1748), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/534 (67%), Positives = 418/534 (79%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|289745069|ref|ZP_06504447.1| adenylate cyclase [Mycobacterium tuberculosis 02_1987] gi|294994875|ref|ZP_06800566.1| adenylate cyclase, putative [Mycobacterium tuberculosis 210] gi|289685597|gb|EFD53085.1| adenylate cyclase [Mycobacterium tuberculosis 02_1987] gi|339294301|gb|AEJ46412.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5079] gi|339297940|gb|AEJ50050.1| adenylate cyclase, putative [Mycobacterium tuberculosis CCDC5180] Length=558 Score = 674 bits (1740), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/534 (66%), Positives = 417/534 (79%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLN FF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNWFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|326902942|gb|EGE49875.1| LOW QUALITY PROTEIN: adenylate cyclase [Mycobacterium tuberculosis W-148] Length=535 Score = 672 bits (1735), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/534 (66%), Positives = 416/534 (78%), Gaps = 1/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA + TYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIDTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLN FF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNWFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 421 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 481 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 534 >gi|183984050|ref|YP_001852341.1| adenylate cyclase [Mycobacterium marinum M] gi|183177376|gb|ACC42486.1| adenylate cyclase [Mycobacterium marinum M] Length=534 Score = 672 bits (1734), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/508 (69%), Positives = 404/508 (80%), Gaps = 0/508 (0%) Query 27 ETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDA 86 E PAYGSWLLG+V E+ R RR+RIQ +LT I+ N++G+ V ++ VA P P+V DA Sbjct 27 EPPAYGSWLLGQVLENQRSRRIRIQVILTSVIVFANLVGIGVVLLIAIVAIPAPNVFTDA 86 Query 87 PHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAV 146 P WV+F + P Y V+A +LGTYW+TR+T + LRWA+EER PS +ARS F VP +VALA Sbjct 87 PWWVTFVVAPAYIVVALVLGTYWITRRTVQTLRWALEERPPSRADARSTFRVPRQVALAT 146 Query 147 LFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVG 206 LWG A TI+YGLAN LFIPRFLF++ + GV+ AT YLLTEFALRP+AAQALE Sbjct 147 ATLWGVGAVASTILYGLANPLFIPRFLFTVSICGVLVATGAYLLTEFALRPVAAQALEAA 206 Query 207 ATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLI 266 P+ GI+GRTM+VWLL SG P VG+ L AI + L+ QF I V+I+ LI Sbjct 207 PPPQRFAPGIMGRTMMVWLLGSGGPLVGINLMAISELVKGSLTKVQFAIGVVIVSTGTLI 266 Query 267 FGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRE 326 FGFILMWI++WLTATPVRVVR ALNRV GDL DLVVFDGTELGELQRGFN MV+GLRE Sbjct 267 FGFILMWIMSWLTATPVRVVRAALNRVANGDLQRDLVVFDGTELGELQRGFNTMVDGLRE 326 Query 327 RERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLL 386 RERVRDLFGRHVGREVA AAERERPKLGGEERHVAVVF+DIVGST+LVTS+P A+VV LL Sbjct 327 RERVRDLFGRHVGREVAIAAERERPKLGGEERHVAVVFIDIVGSTKLVTSQPPADVVALL 386 Query 387 NRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPE 446 NRFF V+VDEV+ H GLVNKF GDASLA+FGAPN L PED ALA AR IA RLASE+PE Sbjct 387 NRFFAVVVDEVDRHCGLVNKFAGDASLAIFGAPNHLERPEDQALAAARTIAARLASEVPE 446 Query 447 CQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGAS 506 C+AGIGVAAGQVVAGNVG+ ERFEYTVIGEPVNEAARLCELAK +P RLLAS L GAS Sbjct 447 CRAGIGVAAGQVVAGNVGSKERFEYTVIGEPVNEAARLCELAKDHPGRLLASGAALDGAS 506 Query 507 ENECARWSLGETVTLRGHDQPIRLTSPV 534 +E ARWS+G+TVTLRGHDQP RL +P+ Sbjct 507 HDERARWSVGKTVTLRGHDQPTRLAAPI 534 >gi|289446915|ref|ZP_06436659.1| adenylate cyclase, putative [Mycobacterium tuberculosis CPHL_A] gi|289419873|gb|EFD17074.1| adenylate cyclase, putative [Mycobacterium tuberculosis CPHL_A] Length=557 Score = 671 bits (1732), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/534 (66%), Positives = 417/534 (79%), Gaps = 2/534 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAA ERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAA-ERERPQLGGEDRH 359 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 360 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 419 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 NRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN Sbjct 420 NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN 479 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 +AARLCELAKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 480 QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 533 >gi|298524825|ref|ZP_07012234.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|298494619|gb|EFI29913.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] Length=552 Score = 671 bits (1731), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/526 (67%), Positives = 413/526 (79%), Gaps = 1/526 (0%) Query 9 RHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIV 68 + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ N+ G++V Sbjct 3 QRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVV 62 Query 69 GAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LRWAIEERTP 127 +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +RWAIEER P Sbjct 63 ALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAP 122 Query 128 SHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSC 187 S + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + GV+ AT+C Sbjct 123 SQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNC 182 Query 188 YLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWE 247 YL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA++ Sbjct 183 YLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHN 242 Query 248 LSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDG 307 L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL GDLVVFDG Sbjct 243 LTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDG 302 Query 308 TELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDI 367 TELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH AVVFVDI Sbjct 303 TELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDI 362 Query 368 VGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPED 427 VGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAPNRL PED Sbjct 363 VGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPED 422 Query 428 AALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCEL 487 AALA ARAIADRLASEMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN+AARLCEL Sbjct 423 AALAAARAIADRLASEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCEL 482 Query 488 AKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 AKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 483 AKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 528 >gi|254364216|ref|ZP_04980262.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] gi|134149730|gb|EBA41775.1| hypothetical adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) [Mycobacterium tuberculosis str. Haarlem] Length=532 Score = 670 bits (1728), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/530 (66%), Positives = 412/530 (78%), Gaps = 0/530 (0%) Query 4 EKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNV 63 K + L +ET++ + R + PAYGSWLLG VSE P RRVRIQ +LT+A++ N+ Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 IGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIE 123 +G+ + +L VAFP PS++ DAP W++F P Y V+ LG+Y++ QT ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 ERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVA 183 E TPS + R+ L PLRVA+ L LW AAL+T +YGLANRLFIP+ +FS GV+ Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDD 243 AT+CY+LTEFALRP+AAQALE G P GI+GRTM+VWLL SGVP G+AL I + Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 TFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLV 303 ++ QF VLI+ + LI GF+LMWILAWLTA PVRVVR AL RVEQGDL GDLV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWILAWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVV 363 VFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLS 423 FVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 HPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAAR 483 PEDAALA ARAIA+RLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 LCELAKS+P+RLLASS TL ASE E A WSLGETVTLRGH+QP RL P Sbjct 482 LCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|298524824|ref|ZP_07012233.1| adenylate cyclase [Mycobacterium tuberculosis 94_M4241A] gi|298494618|gb|EFI29912.1| adenylate cyclase [Mycobacterium tuberculosis 94_M4241A] Length=532 Score = 668 bits (1723), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/530 (66%), Positives = 412/530 (78%), Gaps = 0/530 (0%) Query 4 EKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNV 63 K + L +ET++ + R + PAYGSWLLG VSE P RRVRIQ +LT+A++ N+ Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 IGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIE 123 +G+ + +L VAFP PS++ DAP W++F P Y V+ LG+Y++ QT ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 ERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVA 183 E TPS + R+ L PLRVA+ L LW AAL+T +YGLANRLFIP+ +FS GV+ Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDD 243 AT+CY+LTEFALRP+AAQALE G P GI+GRTM+VWLL SGVP G+AL I + Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 TFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLV 303 ++ QF VLI+ + LI GF+LMWI++WLTA PVRVVR AL RVEQGDL GDLV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVV 363 VFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLS 423 FVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 HPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAAR 483 PEDAALA ARAIA+RLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 LCELAKS+P+RLLASS TL ASE E A WSLGETVTLRGH+QP RL P Sbjct 482 LCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|340626334|ref|YP_004744786.1| adenylate cyclase [Mycobacterium canettii CIPT 140010059] gi|340004524|emb|CCC43667.1| adenylate cyclase, putative [Mycobacterium canettii CIPT 140010059] Length=532 Score = 667 bits (1720), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/530 (66%), Positives = 413/530 (78%), Gaps = 0/530 (0%) Query 4 EKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNV 63 K + L +ET++ + R + PAYGSWLLG VSE P RRVRIQ +LT+A++ N+ Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 IGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIE 123 +G+ + +L VAFP PS++ DAP W++F P Y V+ LG+Y++ QT ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 ERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVA 183 E TPS + R+ L PLRVA+ L LW AAL+T +YGLANRLFIP+ +FS GV+ Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDD 243 AT+CY+LTEFALRP+AAQALE G P GI+GRTM+VWLL SGVP G+AL I + Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 TFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLV 303 ++ QF VLI+ + LI GF+LMWI++WLTA PVRVVR AL RVEQGDL GDLV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVV 363 VFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLS 423 FVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 HPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAAR 483 PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 LCELAKS+P+RLLASS TL GASE E A WSLGETVTLRGH+QP RL P Sbjct 482 LCELAKSHPARLLASSDTLHGASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|289757423|ref|ZP_06516801.1| adenylate cyclase [Mycobacterium tuberculosis T85] gi|289712987|gb|EFD76999.1| adenylate cyclase [Mycobacterium tuberculosis T85] Length=552 Score = 666 bits (1718), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/526 (67%), Positives = 412/526 (79%), Gaps = 1/526 (0%) Query 9 RHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIV 68 + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ N+ G++V Sbjct 3 QRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVV 62 Query 69 GAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LRWAIEERTP 127 +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +RWAIEER P Sbjct 63 ALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAP 122 Query 128 SHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSC 187 S + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + GV+ AT+C Sbjct 123 SQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNC 182 Query 188 YLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWE 247 YL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA++ Sbjct 183 YLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHN 242 Query 248 LSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDG 307 L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL GDLVVFDG Sbjct 243 LTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDG 302 Query 308 TELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDI 367 TELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH AVVFVDI Sbjct 303 TELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDI 362 Query 368 VGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPED 427 VGSTQLV ++PAA VV LLN FF ++V+EV+ H GL+NKF GDA+LA+FGAPNRL PED Sbjct 363 VGSTQLVDNQPAAHVVKLLNWFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPED 422 Query 428 AALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCEL 487 AALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN+AARLCEL Sbjct 423 AALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCEL 482 Query 488 AKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 AKS+P+RLLASS TL ASE E A WSLGETVTLRG+ QP +L SP Sbjct 483 AKSHPARLLASSDTLHAASETERAHWSLGETVTLRGYHQPTQLASP 528 >gi|15840771|ref|NP_335808.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551] gi|289446914|ref|ZP_06436658.1| adenylate cyclase, putative [Mycobacterium tuberculosis CPHL_A] gi|289745068|ref|ZP_06504446.1| adenylate cyclase [Mycobacterium tuberculosis 02_1987] 10 more sequence titles Length=532 Score = 665 bits (1715), Expect = 0.0, Method: Compositional matrix adjust. Identities = 347/530 (66%), Positives = 412/530 (78%), Gaps = 0/530 (0%) Query 4 EKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNV 63 K + L +ET++ + R + PAYGSWLLG VSE P RRVRIQ +LT+A++ N+ Sbjct 2 SKTREQRLRRVLETMTRQHDRLRDPPAYGSWLLGWVSERPLRRRVRIQIILTIALITANL 61 Query 64 IGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIE 123 +G+ + +L VAFP PS++ DAP W++F P Y V+ LG+Y++ QT ALRWA E Sbjct 62 VGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAYTVIGMALGSYYVKVQTLAALRWASE 121 Query 124 ERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVA 183 E TPS + R+ L PLRVA+ L LW AAL+T +YGLANRLFIP+ +FS GV+ Sbjct 122 EHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFTTLYGLANRLFIPQVMFSTLFCGVLV 181 Query 184 ATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDD 243 AT+CY+LTEFALRP+AAQALE G P GI+GRTM+VWLL SGVP G+AL I + Sbjct 182 ATACYMLTEFALRPVAAQALEAGLPPGRFALGIIGRTMVVWLLSSGVPLFGIALLGILEM 241 Query 244 TFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLV 303 ++ QF VLI+ + LI GF+LMWI++WLTA PVRVVR AL RVEQGDL GDLV Sbjct 242 VLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWLTAAPVRVVRAALKRVEQGDLRGDLV 301 Query 304 VFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVV 363 VFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH AVV Sbjct 302 VFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVV 361 Query 364 FVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLS 423 FVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAPNRL Sbjct 362 FVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLD 421 Query 424 HPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAAR 483 PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+VAGNVGA +RFEYTV+G+PVN+AAR Sbjct 422 RPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAAR 481 Query 484 LCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 LCELAKS+P+RLLASS TL ASE E A WSLGETVTLRGH+QP RL P Sbjct 482 LCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVP 531 >gi|183984051|ref|YP_001852342.1| adenylate cyclase [Mycobacterium marinum M] gi|183177377|gb|ACC42487.1| adenylate cyclase [Mycobacterium marinum M] Length=539 Score = 655 bits (1689), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/533 (64%), Positives = 417/533 (79%), Gaps = 0/533 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + + L A+E ++ ++ + E AYGS LLG+++E+P+ RRVRIQ MLT +I+ Sbjct 1 MVATNTVVQRLRRALEKITQQSDQLTENYAYGSRLLGQLTETPQRRRVRIQLMLTSSIMA 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++ + V +L+ VA P+P+VI +AP W++FG+ GY V AF++G++W+T T RALRW Sbjct 61 ANLVAIGVALLLVFVAIPEPNVITEAPRWLTFGVGAGYDVTAFVVGSFWITSNTVRALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 IE R P+ E+R FLVP R+A LFLWG L+T +YGL + FIP++LFS+ G Sbjct 121 YIEGRPPNRAESRETFLVPSRIAAVHLFLWGLGTLLFTTLYGLIDIRFIPKYLFSVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 ++ AT YLLTEFALRP+ AQALE G PR +V GI+GRT+L+WLL SGVP VG+AL A+ Sbjct 181 ILVATGSYLLTEFALRPLTAQALETGPPPRRIVSGIMGRTILIWLLGSGVPVVGIALLAV 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ LS +F + VLI + L+FG +L+ I AWLTATPVRVVR AL RVE+GDL G Sbjct 241 FEIALLHLSEVEFAVGVLIASSATLVFGLLLIAISAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 D+VVFDG+ELGELQ GFN MVEGLRERERVRDLFGRHVGREVAAAAER+ P+LGGEER+V Sbjct 301 DVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAAERKPPQLGGEERYV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDI+GSTQLV++RPA +VV LLNRFF VIVDEV HRGLVNKF+GDASLA+FGAPN Sbjct 361 AVVFVDIIGSTQLVSNRPATDVVQLLNRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L PE AAL+ ARAIA RL +E+PEC+AGIGVAAGQVVAGNVGA+ERFEYTVIG PVNE Sbjct 421 PLECPEVAALSAARAIAGRLCTEVPECRAGIGVAAGQVVAGNVGANERFEYTVIGGPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 AARLCELAKSY +RL+ASS+T+ GA+E E A W+L ETVTLRG D+P RL P Sbjct 481 AARLCELAKSYSARLVASSETVAGATETERAHWNLAETVTLRGRDRPTRLAIP 533 >gi|120405263|ref|YP_955092.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii PYR-1] gi|119958081|gb|ABM15086.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii PYR-1] Length=536 Score = 652 bits (1683), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/537 (63%), Positives = 413/537 (77%), Gaps = 1/537 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + K+ L +E ++ ++GR ETP YGSWLLG+ ES RR+RIQ +LT +L Sbjct 1 MNATKSVPYRLGRVLERVTRQSGRL-ETPDYGSWLLGKPEESQARRRIRIQVILTFLLLF 59 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TN++G+ V +L TVA P PSV DAP W++FG+VP Y V+A +LGT W+T +T +LRW Sbjct 60 TNILGIAVSLLLNTVAIPVPSVFSDAPAWLTFGVVPAYMVVALVLGTAWITSRTVGSLRW 119 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEER+P+ + R+ F+ P RVA +L WG AAL T++YGL + FIPRFLF++G G Sbjct 120 AIEERSPTRTDQRNVFVAPSRVAQMLLLFWGFGAALLTLLYGLQDSAFIPRFLFAVGFPG 179 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 +V AT+CY++TEFALRP+AAQALE G PR L G++GRTM VWLL SGVP +G+ L AI Sbjct 180 IVVATACYMITEFALRPVAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAI 239 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F + LS QF + V+I+ L+FG ILMW+L+WL ATPVRVVR AL VE GDL Sbjct 240 FTLSLRNLSATQFAVAVMIISVVALMFGLILMWLLSWLIATPVRVVRSALKHVEDGDLDC 299 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 ++VVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAE+++ +LGGEERH Sbjct 300 NVVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVARAAEKQKIELGGEERHA 359 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AV+FVDI+GSTQLVTSRPA EVV LLNRFF V+V+EV++H GLVNKF+GDA LAVFGAP Sbjct 360 AVIFVDIIGSTQLVTSRPAVEVVELLNRFFDVVVEEVDNHHGLVNKFEGDAVLAVFGAPV 419 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L E AL+ ARA+A RL +E+PEC AGIGVAAGQVVAGNVGA +RFEYTVIGEPVNE Sbjct 420 SLDSAETEALSAARAMARRLRTEVPECPAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVNE 479 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQL 537 AARLCELAK+ P+ L+AS+ + GA+E+E A W LGETVTLRGHDQP RL +P +L Sbjct 480 AARLCELAKNVPALLVASADAVGGATESERALWKLGETVTLRGHDQPTRLATPAGEL 536 >gi|118619189|ref|YP_907521.1| adenylate cyclase [Mycobacterium ulcerans Agy99] gi|118571299|gb|ABL06050.1| adenylate cyclase [Mycobacterium ulcerans Agy99] Length=528 Score = 648 bits (1671), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/525 (64%), Positives = 411/525 (79%), Gaps = 0/525 (0%) Query 15 VETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLT 74 V+T++ G E+PAYGSWLLG ++ES R RR+RI+GMLT I TNVIG+ VG +L T Sbjct 2 VKTVTRHDGSLLESPAYGSWLLGDLNESQRDRRIRIRGMLTAVIAATNVIGICVGLVLAT 61 Query 75 VAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARS 134 VA P P V+ DAP W++F ++P Y V+AF LG+YWL R+T + LRWAIE R PS + R+ Sbjct 62 VAAPAPHVLSDAPLWITFAVMPAYVVIAFALGSYWLARRTTQMLRWAIERREPSPTDQRN 121 Query 135 AFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFA 194 L P R A+ L +WG L T +YG+AN +FIPRFLF++ G+ T+ Y+ TEFA Sbjct 122 TLLAPFRFAIFHLLVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEFA 181 Query 195 LRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFM 254 LRP+AA AL G GI GRT++VWL SGVP +G+AL IFD++ W++S +F Sbjct 182 LRPVAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLIGMALVVIFDESLWQISQAEFS 241 Query 255 ITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQ 314 I+V+I+ + +L G +LMWIL+WLT TPV+VV AL RVE GDL GDLVVFDGTELG+LQ Sbjct 242 ISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRVEMGDLPGDLVVFDGTELGQLQ 301 Query 315 RGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLV 374 RGFN MV GLRERERVRDLFGRHVGREVAAAAERERPKLGGE+RH+AVVF+DIVGST+LV Sbjct 302 RGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERPKLGGEDRHIAVVFIDIVGSTRLV 361 Query 375 TSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATAR 434 T++P AEVV LLNRFF ++VDEV+ HRGLVNKF GDA+LA+FGAPNRL PED ALA AR Sbjct 362 TTQPPAEVVKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAAR 421 Query 435 AIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSR 494 AIA RLA+E+PECQAGIGVAAGQ VAGNVGA+ERFEYT IGEPVNEAARLCELAKS+P R Sbjct 422 AIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPGR 481 Query 495 LLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQM 539 LLAS++TL GASE+ A+W LG++ LRG DQP RL +P++ ++ Sbjct 482 LLASAETLAGASESVSAQWCLGDSTLLRGLDQPTRLATPIETAEL 526 >gi|183984091|ref|YP_001852382.1| adenylate cyclase [Mycobacterium marinum M] gi|183177417|gb|ACC42527.1| adenylate cyclase [Mycobacterium marinum M] Length=527 Score = 647 bits (1669), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/525 (64%), Positives = 411/525 (79%), Gaps = 0/525 (0%) Query 15 VETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLT 74 ++T++ G E+PAYGSWLLG ++ES R RR+RIQGMLT I TNVIG+ VG +L T Sbjct 1 MKTVTRHDGSLLESPAYGSWLLGDLNESQRDRRIRIQGMLTAVIAATNVIGICVGLVLAT 60 Query 75 VAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARS 134 VA P P V+ DAP W++F ++P Y V+AF LG+YWLTR+T + LRWAIE R PS + R+ Sbjct 61 VAAPAPHVLSDAPLWITFAVMPAYVVIAFALGSYWLTRRTTQMLRWAIERREPSPTDQRN 120 Query 135 AFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFA 194 L P R A+ L +WG L T +YG+AN +FIPRFLF++ G+ T+ Y+ TEFA Sbjct 121 TLLAPFRFAIFHLLVWGTFTILLTALYGMANSMFIPRFLFALSFCGLGVTTASYMFTEFA 180 Query 195 LRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFM 254 LRP+AA AL G GI GRT++VWL SGVP +G+AL IFD++ W++S +F Sbjct 181 LRPVAAMALAAGPPLLRWAPGIRGRTIVVWLTGSGVPLIGMALVVIFDESLWQISQAEFS 240 Query 255 ITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQ 314 I+V+I+ + +L G +LMWIL+WLT TPV+VV AL RVE GDL GDLVVFDGTELG+LQ Sbjct 241 ISVVIVSSAMLALGLLLMWILSWLTTTPVKVVCAALKRVEMGDLPGDLVVFDGTELGQLQ 300 Query 315 RGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLV 374 RGFN MV GLRERERVRDLFGRHVGREVAAAAERERPKLGGE+RH+AVVF+DIVGST+LV Sbjct 301 RGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERPKLGGEDRHIAVVFIDIVGSTRLV 360 Query 375 TSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATAR 434 T++P AEVV LLNRFF ++VDEV+ HRGLVNKF GDA+LA+FGAPNRL PED ALA AR Sbjct 361 TTQPPAEVVKLLNRFFAIVVDEVDRHRGLVNKFLGDAALAIFGAPNRLEQPEDQALAAAR 420 Query 435 AIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSR 494 AIA RLA+E+PECQAGIGVAAGQ VAGNVGA+ERFEYT IGEPVNEAARLCELAKS+P R Sbjct 421 AIARRLAAEVPECQAGIGVAAGQAVAGNVGANERFEYTAIGEPVNEAARLCELAKSFPGR 480 Query 495 LLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQM 539 LLAS++TL GASE+ A+W LG++ LRG QP RL +P++ ++ Sbjct 481 LLASAETLAGASESVSAQWCLGDSTLLRGLGQPTRLATPIETAEL 525 >gi|118619151|ref|YP_907483.1| adenylate cyclase [Mycobacterium ulcerans Agy99] gi|118571261|gb|ABL06012.1| adenylate cyclase [Mycobacterium ulcerans Agy99] Length=539 Score = 646 bits (1666), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/533 (63%), Positives = 414/533 (78%), Gaps = 0/533 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + + L A+E ++ ++ + E AYGS LLG+++E+P+ RRVRIQ MLT +I+ Sbjct 1 MVATNTVVQRLRRALEKITQQSDQLTENYAYGSRLLGQLTETPQRRRVRIQLMLTSSIMA 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 N++ + V +L+ VA P+P+VI +AP W++FG+ GY V AF++G++W+T T RALRW Sbjct 61 ANLVAIGVALLLVFVAIPEPNVITEAPRWLTFGVGAGYDVTAFVVGSFWITSNTVRALRW 120 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 IE R P+ +R FLVP R+A LFLWG L+T +YGL + FIP++LFS+ G Sbjct 121 YIEGRPPNRAVSRETFLVPSRIAAVHLFLWGLGTLLFTTLYGLIDIRFIPKYLFSVSFCG 180 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 ++ AT YLLTEFALRP+ AQALE G PR +V GI+GRT+L+WLL SGVP V +AL A+ Sbjct 181 ILVATGSYLLTEFALRPLTAQALETGPPPRRIVSGIMGRTILIWLLGSGVPVVDIALLAV 240 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F+ LS +F + VLI + L+FG +L+ I AWLTATPVRVVR AL RVE+GDL G Sbjct 241 FEIALLHLSEVEFAVGVLIASSATLVFGLLLIAISAWLTATPVRVVRAALKRVERGDLRG 300 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 D+VVFDG+ELGELQ GFN MVEGLRERERVRDLFGRHVGREVAAAAER+ P+LGGEER+V Sbjct 301 DVVVFDGSELGELQSGFNSMVEGLRERERVRDLFGRHVGREVAAAAERKPPQLGGEERYV 360 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AVVFVDI+GSTQLV++RPA +VV LL+RFF VIVDEV HRGLVNKF+GDASLA+FGAPN Sbjct 361 AVVFVDIIGSTQLVSNRPATDVVQLLDRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPN 420 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L PE AAL+ ARAIA RL +E+PEC AGIGVAAGQVVAGNVGA+ERFEYTVIG PVNE Sbjct 421 PLECPEVAALSAARAIAGRLCTEVPECPAGIGVAAGQVVAGNVGANERFEYTVIGGPVNE 480 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSP 533 AARLCELAKSY +RL+ASS+T+ GA+E E A W+L ETVTLRG D+P RL P Sbjct 481 AARLCELAKSYSTRLVASSETVAGATETERAHWNLAETVTLRGRDRPTRLAIP 533 >gi|145222924|ref|YP_001133602.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK] gi|315443387|ref|YP_004076266.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1] gi|145215410|gb|ABP44814.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK] gi|315261690|gb|ADT98431.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1] Length=536 Score = 643 bits (1658), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/536 (62%), Positives = 404/536 (76%), Gaps = 1/536 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 M + K+ L +E ++ ++GR +TP YGSWLLGR +ES RRVRIQ +LT IL Sbjct 1 MNATKSVPYRLGRVLERVTRQSGRL-DTPGYGSWLLGRPAESQSRRRVRIQIILTFFILF 59 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW 120 TN++G+ V +L T+A P PSV DAP W++FG+ P Y ++A GT W+T +T R+LRW Sbjct 60 TNIMGIAVSLLLNTIAIPVPSVFSDAPAWLTFGVTPAYMLVALFFGTAWITSRTVRSLRW 119 Query 121 AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG 180 AIEER P+ + R+ FL P RVA +L LWG A L T++YGL + FIPRFLF++G G Sbjct 120 AIEERQPTSTDQRNVFLAPARVAQKLLLLWGVGAVLLTVLYGLQDTAFIPRFLFAVGFPG 179 Query 181 VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI 240 +V AT+CY++TEFALRP+AAQALE G PR L G++GRTM VWLL SGVP +G+ L A+ Sbjct 180 IVVATACYMITEFALRPIAAQALEAGRPPRRLAHGVMGRTMTVWLLSSGVPVLGILLLAV 239 Query 241 FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG 300 F + LS QF + V+ + A L+FG LMW+L+WL ATPVRVVR AL +VE GDL Sbjct 240 FSLSLKNLSATQFAVAVIFIAAFALVFGLTLMWLLSWLIATPVRVVRSALKQVEDGDLDC 299 Query 301 DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV 360 +LVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVA AAE+++ +LGGEER Sbjct 300 NLVVFDGTELGELQRGFNSMVHGLRERERVRDLFGRHVGREVALAAEKQQVELGGEERRA 359 Query 361 AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN 420 AV+FVDI+GST+LVTSRPAAEVV LLNRFF V+VDEV+ H GLVNKF+GDA LAVFGAP Sbjct 360 AVIFVDIIGSTKLVTSRPAAEVVELLNRFFDVVVDEVDKHHGLVNKFEGDAVLAVFGAPV 419 Query 421 RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE 480 L + E ALA ARA++ RLA+E+PEC AGIGVA+GQVVAGNVGA ERFEYTVIGEPVNE Sbjct 420 SLDNAEAEALAAARAMSRRLAAEVPECTAGIGVASGQVVAGNVGAKERFEYTVIGEPVNE 479 Query 481 AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQ 536 AARLCEL+K L+AS+ + A+E E W LGETVTLRGH +P L +PV + Sbjct 480 AARLCELSKKIDGHLVASADAVHNATETERRHWELGETVTLRGHAEPTTLATPVDR 535 >gi|289573983|ref|ZP_06454210.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] gi|289538414|gb|EFD42992.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] Length=496 Score = 641 bits (1653), Expect = 0.0, Method: Compositional matrix adjust. Identities = 332/495 (68%), Positives = 392/495 (80%), Gaps = 0/495 (0%) Query 39 VSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGY 98 +SE P RRVRIQ +LT+A++ N++G+ + +L VAFP PS++ DAP W++F P Y Sbjct 1 MSERPLRRRVRIQIILTIALITANLVGIGLAVLLENVAFPTPSIVSDAPLWITFVAGPAY 60 Query 99 CVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWT 158 V+ LG+Y++ QT ALRWA EE TPS + R+ L PLRVA+ L LW AAL+T Sbjct 61 TVIGMALGSYYVKVQTLAALRWASEEHTPSRADQRNTLLAPLRVAVGTLILWAVGAALFT 120 Query 159 IIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVG 218 +YGLANRLFIP+ +FS GV+ AT+CY+LTEFALRP+AAQALE G P GI+G Sbjct 121 TLYGLANRLFIPQVMFSTLFCGVLVATACYMLTEFALRPVAAQALEAGLPPGRFALGIIG 180 Query 219 RTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWL 278 RTM+VWLL SGVP G+AL I + ++ QF VLI+ + LI GF+LMWI++WL Sbjct 181 RTMVVWLLSSGVPLFGIALLGILEMVLQNFTDIQFAYGVLIVSSATLIGGFLLMWIMSWL 240 Query 279 TATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHV 338 TA PVRVVR AL RVEQGDL GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHV Sbjct 241 TAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHV 300 Query 339 GREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVN 398 GREVAAAAERERP+LGGE+RH AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ Sbjct 301 GREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVD 360 Query 399 HHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQV 458 H GL+NKF GDA+LA+FGAPNRL PEDAALA ARAIADRLA+EMPE QAGIGVAAGQ+ Sbjct 361 RHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQI 420 Query 459 VAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGET 518 VAGNVGA +RFEYTV+G+PVN+AARLCELAKS+P+RLLASS TL ASE E A WSLGET Sbjct 421 VAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGET 480 Query 519 VTLRGHDQPIRLTSP 533 VTLRGH+QP RL P Sbjct 481 VTLRGHEQPTRLAVP 495 >gi|108800832|ref|YP_641029.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS] gi|119869972|ref|YP_939924.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] gi|126436430|ref|YP_001072121.1| putative adenylate/guanylate cyclase [Mycobacterium sp. JLS] gi|108771251|gb|ABG09973.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS] gi|119696061|gb|ABL93134.1| putative adenylate/guanylate cyclase [Mycobacterium sp. KMS] gi|126236230|gb|ABN99630.1| putative adenylate/guanylate cyclase [Mycobacterium sp. JLS] Length=540 Score = 636 bits (1640), Expect = 3e-180, Method: Compositional matrix adjust. Identities = 332/528 (63%), Positives = 412/528 (79%), Gaps = 0/528 (0%) Query 3 SEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTN 62 ++K+ + L +E ++ ++GR P+TP YGSWLLG+ E+ + RR+RIQ +LT ILVTN Sbjct 7 AKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTFLILVTN 66 Query 63 VIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAI 122 ++G+ V +L VA P PSV DAP W+++G+VP Y ++A + GT W+T R+LRWAI Sbjct 67 ILGIGVSLLLNAVAIPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVRSLRWAI 126 Query 123 EERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVV 182 EERTP+ + + F P +VA +L WG AL T++YGL + FIPRFLF++G G+V Sbjct 127 EERTPTRADQYNVFRAPWQVARMLLLFWGVGTALLTLLYGLQDSAFIPRFLFAVGFPGIV 186 Query 183 AATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFD 242 AT+CYL+TEFALRP+AAQALE G PR L +G++GRTM VWLL SGVP +G+ L A+F Sbjct 187 VATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGILLLAVFS 246 Query 243 DTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDL 302 + LS QF I V+I+ L+FG ILMW+L+WL ATPVRVVR AL VE+GD L Sbjct 247 LSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERGDFDCQL 306 Query 303 VVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAV 362 VVFDGTELGELQRGFN+MVEGLRERERVRDLFGRHVGREVA AAE+E+ +LGGEERH AV Sbjct 307 VVFDGTELGELQRGFNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGEERHAAV 366 Query 363 VFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRL 422 +FVDI+GSTQ+VTSRPA+E+V LLNRFF VIVDEV+ H GLVNKF+GDA LAVFGAP L Sbjct 367 IFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDEVDRHHGLVNKFEGDAVLAVFGAPVAL 426 Query 423 SHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAA 482 + ALA ARAIA+RL SE+P+C+AGIGVAAGQVVAGNVGA ERFEYTVIGEPVNEAA Sbjct 427 DNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGEPVNEAA 486 Query 483 RLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRL 530 RLCELAKS P+RL+ASS T++ A++ E A W+LG+TVTLRGHD+P L Sbjct 487 RLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTL 534 >gi|118473953|ref|YP_889179.1| adenylate cyclase, family protein 3 [Mycobacterium smegmatis str. MC2 155] gi|118175240|gb|ABK76136.1| adenylate cyclase, family protein 3 [Mycobacterium smegmatis str. MC2 155] Length=535 Score = 623 bits (1606), Expect = 3e-176, Method: Compositional matrix adjust. Identities = 320/535 (60%), Positives = 388/535 (73%), Gaps = 1/535 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPE-TPAYGSWLLGRVSESPRMRRVRIQGMLTVAIL 59 M ++ + R L +ET++ + R P TP YGSW+LGRV+ES RR+RIQ +LT ++ Sbjct 1 MNADNSLARQLGRVLETVTRQNSRLPSGTPEYGSWILGRVTESQSRRRIRIQLILTTFVV 60 Query 60 VTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALR 119 + N++G+ V ++LTV FP PSV ++ + P Y V A ++G W T + +R Sbjct 61 IANLLGIAVSFLVLTVLFPSPSVFDARVAPYTYIVAPAYVVGALVVGVIWATNRVIGNVR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WA+EER P+ + R+ F P R+ +L LW A AL T +YG+ + FIP+ L + Sbjct 121 WALEERPPTPQDQRNTFFAPFRLTRVLLILWAAGTALLTTLYGMVDTNFIPKVLLGISFP 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 G+V + SC+L TEFALRP+AAQALE G P L GI+GRTM+VW L SGVP +G+ L Sbjct 181 GIVVSVSCHLFTEFALRPVAAQALEAGPPPVRLAPGIMGRTMVVWALGSGVPILGILLAG 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 +F T L+ QF V+ L L+FGFILMWIL+WLTATP+RVVR ALNRVEQGDL Sbjct 241 VFAVTLENLTPTQFAYAVMGLAVFALVFGFILMWILSWLTATPIRVVRAALNRVEQGDLD 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 +LVVFDGTELG+LQRGFN MV GLRERERVRDLFGRHVGREVA AE+++ LGGEERH Sbjct 301 TNLVVFDGTELGQLQRGFNSMVHGLRERERVRDLFGRHVGREVAVLAEQQKFTLGGEERH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVD++GSTQLVTSRPA EVV LLNRFF VIVDEV+ HRGLVNKF+GDA LAVFGAP Sbjct 361 AAVVFVDVIGSTQLVTSRPAVEVVELLNRFFAVIVDEVDAHRGLVNKFEGDAVLAVFGAP 420 Query 420 NRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVN 479 L + ED AL AR IA RL E+PE AGIGVAAGQVVAGNVGA +RFEYTVIGEPVN Sbjct 421 VALDNAEDEALGAARGIARRLREEVPELDAGIGVAAGQVVAGNVGAKQRFEYTVIGEPVN 480 Query 480 EAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 EAARLCE AKS P ++ASS TL ASE+E ARWSLGE+VTLRG D+P RL PV Sbjct 481 EAARLCEFAKSVPGHVVASSDTLANASESERARWSLGESVTLRGLDEPTRLAVPV 535 >gi|183983769|ref|YP_001852060.1| adenylate cyclase [Mycobacterium marinum M] gi|183177095|gb|ACC42205.1| adenylate cyclase [Mycobacterium marinum M] Length=549 Score = 611 bits (1576), Expect = 1e-172, Method: Compositional matrix adjust. Identities = 324/526 (62%), Positives = 393/526 (75%), Gaps = 0/526 (0%) Query 19 SPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFP 78 + + GR AYGS LLG P+ R +RI+ M TVAIL N+IG+ V +LLT+A P Sbjct 19 TDKGGRLAAARAYGSRLLGDAGVPPKRRWIRIRTMSTVAILGINLIGICVMLVLLTLAVP 78 Query 79 KPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLV 138 +P+V+ +AP W+++G+ P Y V+A LGT+W+T RALRW IE R PS EA F + Sbjct 79 EPNVLSEAPAWLNYGVGPAYNVIALTLGTWWITALAKRALRWYIEGRRPSLTEATETFRI 138 Query 139 PLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPM 198 P RVA FLWG T +YGL + FI ++LFS+ G++ T YLLTEF LRPM Sbjct 139 PSRVAAVNFFLWGLGTLTMTTLYGLIDTRFIAKYLFSVSFCGILVCTGSYLLTEFWLRPM 198 Query 199 AAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVL 258 AQALE G R + GI+GRT+L+WLL SGVP +G++L A F+ L+ +F + V+ Sbjct 199 TAQALETGPPHRRIGSGIIGRTLLIWLLGSGVPLIGISLFAAFEVALLHLTVVEFAVGVM 258 Query 259 ILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFN 318 I + L+FG +L+ I AWLTATPVR+VR AL +VEQGDL GD+VVFDG+ELGELQ GFN Sbjct 259 IASSATLVFGLLLIAISAWLTATPVRLVRAALKQVEQGDLRGDVVVFDGSELGELQSGFN 318 Query 319 RMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRP 378 MVEGLRERERVRDLFGRHVGREVAAAAER+ P+LGGEER+VAVVFVDI+GSTQLV++RP Sbjct 319 SMVEGLRERERVRDLFGRHVGREVAAAAERKPPQLGGEERYVAVVFVDIIGSTQLVSNRP 378 Query 379 AAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIAD 438 A +VV LLNRFF VIVDEV HRGLVNKF+GDASLA+FGAPN L PE AAL+ ARAIA Sbjct 379 ATDVVQLLNRFFAVIVDEVERHRGLVNKFEGDASLAIFGAPNPLECPEVAALSAARAIAG 438 Query 439 RLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLAS 498 RL +E+PEC+AGIGVAAGQVVAGNVGA+ERFEYTVIG PVNEAARLCELAKSY +RL+AS Sbjct 439 RLCTEVPECRAGIGVAAGQVVAGNVGANERFEYTVIGGPVNEAARLCELAKSYSARLVAS 498 Query 499 SQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMPAQSA 544 S+T+ GA+E E A W+L ETVTLRG D+P L P P QS Sbjct 499 SETVAGATETERAHWNLAETVTLRGRDRPTHLAIPASAPGQPPQSG 544 >gi|289761474|ref|ZP_06520852.1| adenylate cyclase [Mycobacterium tuberculosis GM 1503] gi|289708980|gb|EFD72996.1| adenylate cyclase [Mycobacterium tuberculosis GM 1503] Length=446 Score = 583 bits (1504), Expect = 2e-164, Method: Compositional matrix adjust. Identities = 304/441 (69%), Positives = 349/441 (80%), Gaps = 1/441 (0%) Query 94 IVPGYCVLAFILGTYWLTRQTARA-LRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGA 152 + P Y LA +GTYW+T + RA +RWAIEER PS + R+ L+P RVA L LW Sbjct 5 VAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDI 64 Query 153 AAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSL 212 AL +YGLANR+F+ LFS+ + GV+ AT+CYL TEFALRP+AA+ALE G PR Sbjct 65 GGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRF 124 Query 213 VRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILM 272 GI+GRTM VW L SGVP G+A TA++ L+ Q VLIL LIFGF++M Sbjct 125 APGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVM 184 Query 273 WILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRD 332 WILAWLTA PVRVVR AL RVEQGDL GDLVVFDGTELGELQRGFN MV GLRERERVRD Sbjct 185 WILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRD 244 Query 333 LFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTV 392 LFGRHVGREVAAAAERERP+LGGE+RH AVVFVDIVGSTQLV ++PAA VV LLNRFF + Sbjct 245 LFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAI 304 Query 393 IVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIG 452 +V+EV+ H GL+NKF GDA+LA+FGAPNRL PEDAALA ARAIA+RLA+EMPE QAGIG Sbjct 305 VVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIAERLANEMPEVQAGIG 364 Query 453 VAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECAR 512 VAAGQ+VAGNVGA +RFEYTV+G+PVN+AARLCELAKS+P+RLLASS TL ASE E A Sbjct 365 VAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAH 424 Query 513 WSLGETVTLRGHDQPIRLTSP 533 WSLGETVTLRGH+QP RL P Sbjct 425 WSLGETVTLRGHEQPTRLAVP 445 >gi|169628550|ref|YP_001702199.1| hypothetical protein MAB_1459c [Mycobacterium abscessus ATCC 19977] gi|169240517|emb|CAM61545.1| Conserved hypothetical protein (adenylate cyclase?) [Mycobacterium abscessus] Length=535 Score = 562 bits (1449), Expect = 5e-158, Method: Compositional matrix adjust. Identities = 293/532 (56%), Positives = 383/532 (72%), Gaps = 1/532 (0%) Query 3 SEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTN 62 S +A +R + A+ ++ +TG YGSWLLG ES ++R+RIQ +LTV ++ N Sbjct 5 SIRAVSRRVGRALGAITGQTGNINTGNGYGSWLLGTADESTFIQRIRIQLILTVFVVAAN 64 Query 63 VIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAI 122 +IG+ V +L+TVAFP P+V DAP WV+F IVP Y LA ++G W TR+ +A+RWA+ Sbjct 65 LIGIGVVILLVTVAFPTPNV-FDAPAWVNFVIVPVYIALAVLIGAVWGTRRIFKAVRWAL 123 Query 123 EERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVV 182 +ER P+ + R+AF VP R+ + LW AL+T++YGL + ++IP+ F++G G V Sbjct 124 DERPPTKADQRNAFAVPWRLTVIQSVLWAGGVALFTLLYGLYDPMYIPKIFFAVGFSGAV 183 Query 183 AATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFD 242 + YL TEFA+RP+AA+ALE G R L G++ RT+L W+L SGVP G+ +T I Sbjct 184 VCAANYLFTEFAMRPVAARALEAGYRRRRLASGVMVRTVLAWMLGSGVPAAGIVITGIGA 243 Query 243 DTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDL 302 L+ Q + V+I+ + FG IL+WI +WL ATPV+ V+ A+ RV Q DL DL Sbjct 244 LVLHNLTVSQLAVAVIIIAGAIPSFGLILIWIASWLMATPVKEVQTAIKRVAQNDLDIDL 303 Query 303 VVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAV 362 VV+DGTELGELQ GFN MVEGLRERERVRDLFG+HVGREVAAAAE+++P+LGGEERH+AV Sbjct 304 VVYDGTELGELQAGFNTMVEGLRERERVRDLFGKHVGREVAAAAEQQQPELGGEERHIAV 363 Query 363 VFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRL 422 +F DIVGST+L +RPA EVV LLNRFFTV+V+E++ + G+VNKF+GDA+LAVFGAP R Sbjct 364 LFADIVGSTRLAATRPAVEVVALLNRFFTVVVEEIDRYEGMVNKFEGDATLAVFGAPVRQ 423 Query 423 SHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAA 482 PE ALA ARAIA RL +E+PECQAGIGVA+GQ VAGN+GAH+RFEYTVIG+PVNEAA Sbjct 424 DRPESQALAAARAIARRLRTEVPECQAGIGVASGQAVAGNIGAHDRFEYTVIGDPVNEAA 483 Query 483 RLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPV 534 RLCEL+K+ P L+AS T+ A E W G+TVTLRG +P L PV Sbjct 484 RLCELSKTVPGHLVASLDTVLRAHHREALHWRSGDTVTLRGRTEPTELAVPV 535 >gi|306792738|ref|ZP_07431040.1| putative HAMP domain protein [Mycobacterium tuberculosis SUMu005] gi|308338807|gb|EFP27658.1| putative HAMP domain protein [Mycobacterium tuberculosis SUMu005] Length=435 Score = 548 bits (1413), Expect = 8e-154, Method: Compositional matrix adjust. Identities = 275/435 (64%), Positives = 330/435 (76%), Gaps = 1/435 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDAALATAR 434 NRL PEDAALA AR Sbjct 421 NRLDRPEDAALAAAR 435 >gi|306775497|ref|ZP_07413834.1| adenylate cyclase [Mycobacterium tuberculosis SUMu001] gi|308216000|gb|EFO75399.1| adenylate cyclase [Mycobacterium tuberculosis SUMu001] Length=429 Score = 541 bits (1394), Expect = 1e-151, Method: Compositional matrix adjust. Identities = 270/429 (63%), Positives = 325/429 (76%), Gaps = 1/429 (0%) Query 1 MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV 60 MP++K + L A+ET++ + G+ PETPAYGSWLLGRVSESP R VRI+ ++TV I+ Sbjct 1 MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT 60 Query 61 TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARA-LR 119 N+ G++V +++T AFP PS+ DAP WV+FG+ P Y LA +GTYW+T + RA +R Sbjct 61 ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR 120 Query 120 WAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVI 179 WAIEER PS + R+ L+P RVA L LW AL +YGLANR+F+ LFS+ + Sbjct 121 WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC 180 Query 180 GVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTA 239 GV+ AT+CYL TEFALRP+AA+ALE G PR GI+GRTM VW L SGVP G+A TA Sbjct 181 GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA 240 Query 240 IFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLS 299 ++ L+ Q VLIL LIFGF++MWILAWLTA PVRVVR AL RVEQGDL Sbjct 241 LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR 300 Query 300 GDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERH 359 GDLVVFDGTELGELQRGFN MV GLRERERVRDLFGRHVGREVAAAAERERP+LGGE+RH Sbjct 301 GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH 360 Query 360 VAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAP 419 AVVFVDIVGSTQLV ++PAA VV LLNRFF ++V+EV+ H GL+NKF GDA+LA+FGAP Sbjct 361 AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP 420 Query 420 NRLSHPEDA 428 NRL PEDA Sbjct 421 NRLDRPEDA 429 Lambda K H 0.324 0.137 0.418 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1270886033316 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40