BLASTP 2.2.25+
Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
15,229,318 sequences; 5,219,829,388 total letters
Query= Rv1625c
Length=443
Score E
Sequences producing significant alignments: (Bits) Value
gi|15841080|ref|NP_336117.1| adenylate cyclase, putative [Mycoba... 884 0.0
gi|289443077|ref|ZP_06432821.1| membrane-anchored adenylyl cycla... 882 0.0
gi|254231826|ref|ZP_04925153.1| membrane-anchored adenylyl cycla... 868 0.0
gi|31792811|ref|NP_855304.1| membrane-anchored adenylyl cyclase ... 833 0.0
gi|339294580|gb|AEJ46691.1| membrane-anchored adenylyl cyclase C... 786 0.0
gi|118467309|ref|YP_882345.1| adenylate cyclase [Mycobacterium a... 628 7e-178
gi|183982442|ref|YP_001850733.1| membrane-anchored adenylyl cycl... 625 5e-177
gi|336457904|gb|EGO36897.1| family 3 adenylate cyclase [Mycobact... 609 3e-172
gi|41407416|ref|NP_960252.1| hypothetical protein MAP1318c [Myco... 607 1e-171
gi|254820976|ref|ZP_05225977.1| adenylate cyclase [Mycobacterium... 587 2e-165
gi|254775609|ref|ZP_05217125.1| adenylate cyclase [Mycobacterium... 580 1e-163
gi|296164493|ref|ZP_06847064.1| adenylate cyclase [Mycobacterium... 579 4e-163
gi|240168002|ref|ZP_04746661.1| membrane-anchored adenylyl cycla... 575 7e-162
gi|342860804|ref|ZP_08717454.1| adenylate cyclase [Mycobacterium... 567 1e-159
gi|254550629|ref|ZP_05141076.1| membrane-anchored adenylyl cycla... 556 3e-156
gi|108799991|ref|YP_640188.1| adenylate/guanylate cyclase [Mycob... 507 2e-141
gi|126435620|ref|YP_001071311.1| adenylate cyclase [Mycobacteriu... 506 4e-141
gi|145224160|ref|YP_001134838.1| putative adenylate/guanylate cy... 461 9e-128
gi|333990763|ref|YP_004523377.1| membrane-anchored adenylyl cycl... 454 1e-125
gi|315444495|ref|YP_004077374.1| family 3 adenylate cyclase [Myc... 451 1e-124
gi|88191822|pdb|1YK9|A Chain A, Crystal Structure Of A Mutant Fo... 407 2e-111
gi|120403823|ref|YP_953652.1| putative adenylate/guanylate cycla... 405 7e-111
gi|183980691|ref|YP_001848982.1| membrane-anchored adenylyl cycl... 393 4e-107
gi|54124771|gb|AAV30109.1| Cya1625 [Mycobacterium smegmatis str.... 338 1e-90
gi|334116607|ref|ZP_08490699.1| adenylate/guanylate cyclase with... 249 6e-64
gi|332706561|ref|ZP_08426622.1| PAS domain S-box protein [Lyngby... 249 6e-64
gi|254412328|ref|ZP_05026102.1| PAS fold family [Microcoleus cht... 241 1e-61
gi|300024217|ref|YP_003756828.1| adenylate/guanylate cyclase [Hy... 240 3e-61
gi|119486420|ref|ZP_01620478.1| adenylate cyclase [Lyngbya sp. P... 239 6e-61
gi|300866069|ref|ZP_07110799.1| Adenylate and Guanylate cyclase ... 239 6e-61
gi|119484312|ref|ZP_01618929.1| adenylate cyclase [Lyngbya sp. P... 238 1e-60
gi|300865804|ref|ZP_07110557.1| Adenylate/guanylate cyclase [Osc... 238 2e-60
gi|254413152|ref|ZP_05026924.1| PAS fold family [Microcoleus cht... 237 3e-60
gi|254414359|ref|ZP_05028126.1| PAS fold family [Microcoleus cht... 236 4e-60
gi|254412114|ref|ZP_05025889.1| PAS fold family [Microcoleus cht... 236 7e-60
gi|254413324|ref|ZP_05027095.1| Adenylate and Guanylate cyclase ... 235 1e-59
gi|119487004|ref|ZP_01620876.1| two-component hybrid sensor and ... 235 1e-59
gi|119489014|ref|ZP_01621949.1| Extracellular ligand-binding rec... 234 2e-59
gi|291567024|dbj|BAI89296.1| putative ABC transporter substrate-... 234 3e-59
gi|300865561|ref|ZP_07110340.1| PAS fold family [Oscillatoria sp... 233 6e-59
gi|254415242|ref|ZP_05029004.1| hypothetical protein MC7420_2668... 233 6e-59
gi|209522792|ref|ZP_03271350.1| adenylate/guanylate cyclase [Art... 233 7e-59
gi|254412323|ref|ZP_05026097.1| PAS fold family [Microcoleus cht... 232 8e-59
gi|338737510|ref|YP_004674472.1| Adenylate/guanylate cyclase [Hy... 232 9e-59
gi|254410382|ref|ZP_05024161.1| Adenylate and Guanylate cyclase ... 231 1e-58
gi|254410580|ref|ZP_05024359.1| Adenylate and Guanylate cyclase ... 231 2e-58
gi|209528443|ref|ZP_03276873.1| adenylate/guanylate cyclase [Art... 230 4e-58
gi|300866944|ref|ZP_07111616.1| putative Adenylate cyclase [Osci... 230 4e-58
gi|334120376|ref|ZP_08494457.1| adenylate/guanylate cyclase with... 229 6e-58
gi|119487593|ref|ZP_01621203.1| adenylate cyclase [Lyngbya sp. P... 229 6e-58
>gi|15841080|ref|NP_336117.1| adenylate cyclase, putative [Mycobacterium tuberculosis CDC1551]
gi|57116894|ref|NP_216141.2| membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase)
(adenylate cyclase) [Mycobacterium tuberculosis H37Rv]
gi|148661420|ref|YP_001282943.1| membrane-anchored adenylyl cyclase Cya [Mycobacterium tuberculosis
H37Ra]
31 more sequence titles
Length=443
Score = 884 bits (2284), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 442/443 (99%), Positives = 443/443 (100%), Gaps = 0/443 (0%)
Query 1 VAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
+AARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG
Sbjct 1 MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
Query 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV
Sbjct 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
Query 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS
Sbjct 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
Query 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER
Sbjct 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
Query 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD
Sbjct 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
Query 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR
Sbjct 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
Query 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY
Sbjct 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
Query 421 LIGRKVAADPGEVRGAEPRTAGV 443
LIGRKVAADPGEVRGAEPRTAGV
Sbjct 421 LIGRKVAADPGEVRGAEPRTAGV 443
>gi|289443077|ref|ZP_06432821.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
T46]
gi|289569670|ref|ZP_06449897.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
T17]
gi|289750170|ref|ZP_06509548.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
T92]
gi|289753711|ref|ZP_06513089.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
EAS054]
gi|289415996|gb|EFD13236.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
T46]
gi|289543424|gb|EFD47072.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
T17]
gi|289690757|gb|EFD58186.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
T92]
gi|289694298|gb|EFD61727.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
EAS054]
Length=443
Score = 882 bits (2278), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 440/443 (99%), Positives = 441/443 (99%), Gaps = 0/443 (0%)
Query 1 VAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
+AARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG
Sbjct 1 MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
Query 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV
Sbjct 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
Query 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
GTDAGAQFFF VAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS
Sbjct 121 GTDAGAQFFFFVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
Query 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER
Sbjct 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
Query 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD
Sbjct 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
Query 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR
Sbjct 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
Query 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY
Sbjct 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
Query 421 LIGRKVAADPGEVRGAEPRTAGV 443
LIGRKVAADPGEVRGAEPRT GV
Sbjct 421 LIGRKVAADPGEVRGAEPRTVGV 443
>gi|254231826|ref|ZP_04925153.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
C]
gi|124600885|gb|EAY59895.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
C]
Length=466
Score = 868 bits (2244), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 434/435 (99%), Positives = 435/435 (100%), Gaps = 0/435 (0%)
Query 1 VAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
+AARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG
Sbjct 1 MAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
Query 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV
Sbjct 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
Query 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS
Sbjct 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
Query 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER
Sbjct 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
Query 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD
Sbjct 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
Query 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR
Sbjct 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
Query 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY
Sbjct 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
Query 421 LIGRKVAADPGEVRG 435
LIGRKVAADPGEVRG
Sbjct 421 LIGRKVAADPGEVRG 435
>gi|31792811|ref|NP_855304.1| membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase)
(adenylate cyclase) [Mycobacterium bovis AF2122/97]
gi|121637532|ref|YP_977755.1| membrane-anchored adenylyl cyclase cya [Mycobacterium bovis BCG
str. Pasteur 1173P2]
gi|167970663|ref|ZP_02552940.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
H37Ra]
37 more sequence titles
Length=418
Score = 833 bits (2151), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 417/418 (99%), Positives = 418/418 (100%), Gaps = 0/418 (0%)
Query 26 VRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV 85
+RTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV
Sbjct 1 MRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV 60
Query 86 TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH 145
TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH
Sbjct 61 TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH 120
Query 146 TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT 205
TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT
Sbjct 121 TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT 180
Query 206 ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS 265
ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS
Sbjct 181 ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS 240
Query 266 STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALD 325
STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALD
Sbjct 241 STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALD 300
Query 326 MTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQ 385
MTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQ
Sbjct 301 MTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQ 360
Query 386 IQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 443
IQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV
Sbjct 361 IQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 418
>gi|339294580|gb|AEJ46691.1| membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase)
(adenylate cyclase) [Mycobacterium tuberculosis CCDC5079]
Length=397
Score = 786 bits (2030), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 395/397 (99%), Positives = 396/397 (99%), Gaps = 0/397 (0%)
Query 47 VLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFI 106
+LTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPL HRFGGLVAPLTFI
Sbjct 1 MLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLPHRFGGLVAPLTFI 60
Query 107 GTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFL 166
GTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFL
Sbjct 61 GTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFL 120
Query 167 VPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANM 226
VPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANM
Sbjct 121 VPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANM 180
Query 227 LPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDEL 286
LPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDEL
Sbjct 181 LPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDEL 240
Query 287 VDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG 346
VDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG
Sbjct 241 VDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG 300
Query 347 LATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERG 406
LATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERG
Sbjct 301 LATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERG 360
Query 407 HINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 443
HINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV
Sbjct 361 HINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 397
>gi|118467309|ref|YP_882345.1| adenylate cyclase [Mycobacterium avium 104]
gi|118168596|gb|ABK69493.1| adenylate cyclase [Mycobacterium avium 104]
Length=443
Score = 628 bits (1619), Expect = 7e-178, Method: Compositional matrix adjust.
Identities = 318/443 (72%), Positives = 359/443 (82%), Gaps = 0/443 (0%)
Query 1 VAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
+AA+ CGA P+ GS++RPDCV A R Q+RA QHYA+S AR+ RVL I AWLAV+V
Sbjct 1 MAAKSCGAAPLWPTGSSKRPDCVAAARAQSRARNQHYADSAARQSRVLAIAAWLAVLVCA 60
Query 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
F L+Q+ TGA W I +NV A+ FAIVP LHRFG LVAPLTF+G AYV +F WDV
Sbjct 61 DFILLQVVTGAWTWQIVSLNVVAALIFAIVPWLHRFGDLVAPLTFLGAAYVTVFVSCWDV 120
Query 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
GT +G Q+FFLV A LV+L++GIEHT LA LAA+ AGLVIA+EF P DTGLQP WA S
Sbjct 121 GTASGGQYFFLVGACLVLLVMGIEHTVLAAVLAAIGAGLVIAVEFAFPRDTGLQPAWAQS 180
Query 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
+SFV+T VSAC + VWFALRDT RAEAVME+E+ RSEALLANMLP SIAERLK +
Sbjct 181 MSFVVTIVSACIMVFVAVWFALRDTQRAEAVMESEYQRSEALLANMLPGSIAERLKHSDG 240
Query 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
+IIADKYD+ASVLFADIVGFTERAS TAPADLVRFL+RLY AFDELVD+HGLEKIKVSGD
Sbjct 241 DIIADKYDDASVLFADIVGFTERASGTAPADLVRFLNRLYIAFDELVDKHGLEKIKVSGD 300
Query 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
SYMVVSGVPR RPDH ALADFALDM VAA LKDP G PVPLRVG+A GPVVAGVVGSR
Sbjct 301 SYMVVSGVPRVRPDHATALADFALDMVKVAAALKDPYGRPVPLRVGMACGPVVAGVVGSR 360
Query 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
RFFYDVWGDAVNVASRMESTDSVG+IQVP+ +YERL +FVL+ERG I VKGKGVMRTWY
Sbjct 361 RFFYDVWGDAVNVASRMESTDSVGRIQVPETMYERLASEFVLQERGRIEVKGKGVMRTWY 420
Query 421 LIGRKVAADPGEVRGAEPRTAGV 443
LIGRK A P ++ +P TA V
Sbjct 421 LIGRKPAEAPTDLVAEQPHTAHV 443
>gi|183982442|ref|YP_001850733.1| membrane-anchored adenylyl cyclase Cya [Mycobacterium marinum
M]
gi|183175768|gb|ACC40878.1| membrane-anchored adenylyl cyclase Cya [Mycobacterium marinum
M]
Length=446
Score = 625 bits (1612), Expect = 5e-177, Method: Compositional matrix adjust.
Identities = 322/442 (73%), Positives = 362/442 (82%), Gaps = 1/442 (0%)
Query 2 AARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGS 61
+A+KC ++DG RPD V AVR Q R QHYA S ARR RVL+I A LAV+++ S
Sbjct 6 SAKKCRTARRSSDG-LPRPDSVAAVREQTRDLNQHYAHSAARRARVLSIAALLAVLISSS 64
Query 62 FALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVG 121
F L+Q T A W I LIN+ + FA VP+LHRFG LVAPLTF+G AYV++FA W+VG
Sbjct 65 FILVQFLTQAWIWQITLINIAATLVFATVPMLHRFGELVAPLTFVGAAYVSVFASCWNVG 124
Query 122 TDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSV 181
T +GAQ FFLV A LVVL++GIEH LA GLAA+AA L+I +EF+VP +TG Q W S+
Sbjct 125 TGSGAQMFFLVGACLVVLVLGIEHVVLASGLAALAAALIITVEFVVPRNTGAQSAWLQSL 184
Query 182 SFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERN 241
F++TTVSAC + TVWFALRDTARAEAVMEA++DRSEALLANMLP S+A+RLKEPERN
Sbjct 185 GFIITTVSACLLVFVTVWFALRDTARAEAVMEAQYDRSEALLANMLPVSVADRLKEPERN 244
Query 242 IIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDS 301
IIADKY+EASVLFADIVGFTERASSTAPADLVRFLDRLYSAFD LVD++GLEKIKVSGDS
Sbjct 245 IIADKYEEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDALVDKYGLEKIKVSGDS 304
Query 302 YMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRR 361
YMVVSGVPRPRPDH QALADFALDM +VAA +KDP VPLRVGLATGPVVAGVVGSRR
Sbjct 305 YMVVSGVPRPRPDHVQALADFALDMVDVAAGMKDPHNRSVPLRVGLATGPVVAGVVGSRR 364
Query 362 FFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYL 421
FFYDVWGDAVNVASRMESTDSVG+IQVPDEVYERL DFVL+ERGHINVKGKGVMRTWYL
Sbjct 365 FFYDVWGDAVNVASRMESTDSVGKIQVPDEVYERLNKDFVLQERGHINVKGKGVMRTWYL 424
Query 422 IGRKVAADPGEVRGAEPRTAGV 443
IGRK +P V EP A V
Sbjct 425 IGRKPIDEPTAVPADEPNAARV 446
>gi|336457904|gb|EGO36897.1| family 3 adenylate cyclase [Mycobacterium avium subsp. paratuberculosis
S397]
Length=443
Score = 609 bits (1571), Expect = 3e-172, Method: Compositional matrix adjust.
Identities = 318/443 (72%), Positives = 360/443 (82%), Gaps = 0/443 (0%)
Query 1 VAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
+AA+ CGA P+ +GS++RPDCV A R Q+RA QHYA+S AR+ RVL I AWLAV+V
Sbjct 1 MAAKSCGAAPLWPNGSSKRPDCVAAARAQSRARNQHYADSAARQSRVLAIAAWLAVLVCA 60
Query 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
F L+Q+ TGA W I +NV A+ FAIVP LHRFG LVAPLTF+G AYV +F WDV
Sbjct 61 DFILLQVVTGAWTWQIVSLNVVAALIFAIVPWLHRFGDLVAPLTFLGAAYVTVFVSCWDV 120
Query 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
GT +G Q+FFLV A LV+L++GIEHT LA LAA+ AGLVIA+EF P DTGLQP WA S
Sbjct 121 GTASGGQYFFLVGACLVLLVMGIEHTVLAAVLAAIGAGLVIAVEFAFPRDTGLQPAWAQS 180
Query 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
+SFV+T VSAC + VWFALRDT RAEAVME+E+ RSEALLANMLP SIAERLK +
Sbjct 181 MSFVVTIVSACIMVFVAVWFALRDTQRAEAVMESEYQRSEALLANMLPGSIAERLKHSDG 240
Query 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
+IIADKYD+ASVLFADIVGFTERAS TAPADLVRFL+RLY AFDELVD+HGLEKIKVSGD
Sbjct 241 DIIADKYDDASVLFADIVGFTERASGTAPADLVRFLNRLYIAFDELVDKHGLEKIKVSGD 300
Query 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
SYMVVSGVPR RPDH ALADFALDM VAA LKDP G PVPLRVG+A GPVVAGVVGSR
Sbjct 301 SYMVVSGVPRVRPDHAAALADFALDMVKVAAALKDPYGRPVPLRVGMACGPVVAGVVGSR 360
Query 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
RFFYDVWGDAVNVASRMESTDSVG+IQVP+ +YERL +FVL+ERG I VKGKGVMRTWY
Sbjct 361 RFFYDVWGDAVNVASRMESTDSVGRIQVPETMYERLAPEFVLQERGRIEVKGKGVMRTWY 420
Query 421 LIGRKVAADPGEVRGAEPRTAGV 443
LIGRK A P ++ +P TA V
Sbjct 421 LIGRKPAEAPTDLVAEQPHTAHV 443
>gi|41407416|ref|NP_960252.1| hypothetical protein MAP1318c [Mycobacterium avium subsp. paratuberculosis
K-10]
gi|41395768|gb|AAS03635.1| hypothetical protein MAP_1318c [Mycobacterium avium subsp. paratuberculosis
K-10]
Length=443
Score = 607 bits (1565), Expect = 1e-171, Method: Compositional matrix adjust.
Identities = 317/443 (72%), Positives = 360/443 (82%), Gaps = 0/443 (0%)
Query 1 VAARKCGAPPIAADGSTRRPDCVTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTG 60
+AA+ CGA P+ +GS++RPDCV A R Q+RA QHYA+S AR+ RVL I AWLAV+V
Sbjct 1 MAAKSCGAAPLWPNGSSKRPDCVAAARAQSRARNQHYADSAARQSRVLAIAAWLAVLVCA 60
Query 61 SFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDV 120
F L+Q+ TGA W I +NV A+ FAIVP LHRFG LVAPLTF+G AYV +F WDV
Sbjct 61 DFILLQVVTGAWTWQIVSLNVVAALIFAIVPWLHRFGDLVAPLTFLGAAYVTVFVSCWDV 120
Query 121 GTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMS 180
GT +G Q+FFLV A LV+L++GIEHT LA LAA+ AGLVIA+EF P DTGLQP WA S
Sbjct 121 GTASGGQYFFLVGACLVLLVMGIEHTVLAAVLAAIGAGLVIAVEFAFPRDTGLQPAWAQS 180
Query 181 VSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPER 240
+SFV+T VSAC + VWFALRDT RAEAVME+E+ RSEALLANMLP SIAERLK +
Sbjct 181 MSFVVTIVSACIMVFVAVWFALRDTQRAEAVMESEYQRSEALLANMLPGSIAERLKHSDG 240
Query 241 NIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGD 300
+IIADKYD+ASVLFADIVGFTERAS TAPADLVRFL+RLY AFD+LVD+HGLEKIKVSGD
Sbjct 241 DIIADKYDDASVLFADIVGFTERASGTAPADLVRFLNRLYIAFDDLVDKHGLEKIKVSGD 300
Query 301 SYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSR 360
SYMVVSGVPR RPDH ALADFALDM VAA LKDP G PVPLRVG+A GPVVAGVVGSR
Sbjct 301 SYMVVSGVPRVRPDHAAALADFALDMVKVAAALKDPYGRPVPLRVGMACGPVVAGVVGSR 360
Query 361 RFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWY 420
RFFYDVWGDAVNVASRMESTDSVG+IQVP+ +YERL +FVL+ERG I VKGKGVMRTWY
Sbjct 361 RFFYDVWGDAVNVASRMESTDSVGRIQVPETMYERLAPEFVLQERGRIEVKGKGVMRTWY 420
Query 421 LIGRKVAADPGEVRGAEPRTAGV 443
LIGRK A P ++ +P TA V
Sbjct 421 LIGRKPAEAPTDLVAEQPHTAHV 443
>gi|254820976|ref|ZP_05225977.1| adenylate cyclase [Mycobacterium intracellulare ATCC 13950]
Length=397
Score = 587 bits (1512), Expect = 2e-165, Method: Compositional matrix adjust.
Identities = 292/397 (74%), Positives = 323/397 (82%), Gaps = 0/397 (0%)
Query 47 VLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFI 106
+L I AWLAV+V F +QL TG W I +N A+ FA VP LHRFG L+APLTFI
Sbjct 1 MLAIAAWLAVLVCVDFVALQLITGVWTWQIISLNALAAMIFAAVPWLHRFGDLIAPLTFI 60
Query 107 GTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFL 166
G AYV +F WD GT GAQFFFLV A LVVLL+GIEHT LA GL AV AGLVIALEFL
Sbjct 61 GAAYVTVFVSTWDAGTGTGAQFFFLVGACLVVLLLGIEHTVLAAGLTAVGAGLVIALEFL 120
Query 167 VPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANM 226
VP DTGLQP WA S++FV+T VSAC + VWFALRDT RAEAVMEAE++RSEALLANM
Sbjct 121 VPRDTGLQPAWAQSMTFVVTIVSACVMVFVAVWFALRDTQRAEAVMEAEYERSEALLANM 180
Query 227 LPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDEL 286
LP SIAERLK R++IADKYDE SVLFADIVGFTERAS+T PADLVRFL+RLY AFDEL
Sbjct 181 LPGSIAERLKSSSRSVIADKYDEVSVLFADIVGFTERASATTPADLVRFLNRLYGAFDEL 240
Query 287 VDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVG 346
VD+HGLEKIKVSGDSYMVVSGVPR RPDH ALADFALDM NVAA LKDP G+PV LR+G
Sbjct 241 VDKHGLEKIKVSGDSYMVVSGVPRARPDHAFALADFALDMANVAAALKDPHGDPVALRMG 300
Query 347 LATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERG 406
+A GPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVG+IQVP+ +YERLK++FVL+ERG
Sbjct 301 MACGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGRIQVPEAMYERLKNEFVLQERG 360
Query 407 HINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 443
I VKGKGVMRTWYLIGRK +P ++ P T V
Sbjct 361 RIEVKGKGVMRTWYLIGRKADEEPADLLTGRPHTVHV 397
>gi|254775609|ref|ZP_05217125.1| adenylate cyclase [Mycobacterium avium subsp. avium ATCC 25291]
Length=421
Score = 580 bits (1496), Expect = 1e-163, Method: Compositional matrix adjust.
Identities = 300/410 (74%), Positives = 335/410 (82%), Gaps = 0/410 (0%)
Query 34 TQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLL 93
QHYA+S AR+ RVL I AWLAV+V F L+Q+ TGA W I +NV A+ FAIVP L
Sbjct 12 NQHYADSAARQSRVLAIAAWLAVLVCADFILLQVVTGAWTWQIVSLNVVAALIFAIVPWL 71
Query 94 HRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLA 153
HRFG LVAPLTF+G AYV +F WDVGT +G Q+FFLV A LV+L++GIEHT LA LA
Sbjct 72 HRFGDLVAPLTFLGAAYVTVFVSCWDVGTASGGQYFFLVGACLVLLVMGIEHTVLAAVLA 131
Query 154 AVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVME 213
A+ AGLVIA+EF P DTGLQP WA S+SFV+T VSAC + VWFALRDT RAEAVME
Sbjct 132 AIGAGLVIAVEFAFPRDTGLQPAWAQSMSFVVTIVSACIMVFVAVWFALRDTQRAEAVME 191
Query 214 AEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLV 273
+E+ RSEALLANMLP SIAERLK + +IIADKYD+ASVLFADIVGFTERAS TAPADLV
Sbjct 192 SEYQRSEALLANMLPGSIAERLKHSDGDIIADKYDDASVLFADIVGFTERASGTAPADLV 251
Query 274 RFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQL 333
RFL+RLY AFDELVD+HGLEKIKVSGDSYMVVSGVPR RPDH ALADFALDM VAA L
Sbjct 252 RFLNRLYIAFDELVDKHGLEKIKVSGDSYMVVSGVPRVRPDHAAALADFALDMVKVAAAL 311
Query 334 KDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVY 393
KDP G PVPLRVG+A GPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVG+IQVP+ +Y
Sbjct 312 KDPYGRPVPLRVGMACGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGRIQVPETMY 371
Query 394 ERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 443
ERL +FVL+ERG I VKGKGVMRTWYLIGRK A P ++ +P TA V
Sbjct 372 ERLAPEFVLQERGRIEVKGKGVMRTWYLIGRKPAEAPTDLVAEQPHTAHV 421
>gi|296164493|ref|ZP_06847064.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614]
gi|295900093|gb|EFG79528.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614]
Length=421
Score = 579 bits (1492), Expect = 4e-163, Method: Compositional matrix adjust.
Identities = 314/421 (75%), Positives = 357/421 (85%), Gaps = 0/421 (0%)
Query 23 VTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVF 82
+ AVR Q R QHYA S ARR RVLTITAWLAV+V+ SF L+Q+ G W ++ INV
Sbjct 1 MAAVRAQTRDRNQHYAASAARRARVLTITAWLAVMVSVSFVLVQILGGTWLWQVSSINVL 60
Query 83 TAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVG 142
A+ FA VP L RFG LVAPLTF+G AYV++FA DVGT +GA+FFFLV A +VVLL+G
Sbjct 61 GAMIFAAVPWLQRFGELVAPLTFMGAAYVSVFASCLDVGTGSGAEFFFLVGACIVVLLLG 120
Query 143 IEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFAL 202
IEH LA LAA+AAGL+IA+EFL+P DTGLQP WA S FV+T VS+ + V TVWFAL
Sbjct 121 IEHIVLASALAAIAAGLIIAVEFLIPRDTGLQPAWAQSTGFVVTAVSSVVMVVVTVWFAL 180
Query 203 RDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTE 262
RDTARAEAVMEA+++RSEALLANMLPASIAERLKEP+R++IADKYD ASVLFADIVGFTE
Sbjct 181 RDTARAEAVMEAQYERSEALLANMLPASIAERLKEPDRSVIADKYDVASVLFADIVGFTE 240
Query 263 RASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADF 322
RASSTAPADLVRFLDRLYSAFD LVD+HGLEKIKVSGDSYMVVSGVPRPRPDH QALADF
Sbjct 241 RASSTAPADLVRFLDRLYSAFDALVDKHGLEKIKVSGDSYMVVSGVPRPRPDHAQALADF 300
Query 323 ALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS 382
ALDM NVAA L+DP GN VPLR+G+A GPVVAGVVG+RRFFYDVWGDAVNVASRMESTDS
Sbjct 301 ALDMANVAAGLQDPHGNAVPLRMGMACGPVVAGVVGARRFFYDVWGDAVNVASRMESTDS 360
Query 383 VGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAG 442
VG+IQVP+ +YERLKDDFVL+ERGHI+VKGKG+MRTWYLIGRK +P ++ + RTA
Sbjct 361 VGRIQVPEAMYERLKDDFVLQERGHIDVKGKGLMRTWYLIGRKATEEPTDLLAKDSRTAH 420
Query 443 V 443
V
Sbjct 421 V 421
>gi|240168002|ref|ZP_04746661.1| membrane-anchored adenylyl cyclase Cya [Mycobacterium kansasii
ATCC 12478]
Length=418
Score = 575 bits (1481), Expect = 7e-162, Method: Compositional matrix adjust.
Identities = 320/418 (77%), Positives = 356/418 (86%), Gaps = 0/418 (0%)
Query 26 VRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV 85
+R Q R QHYA S ARR R+L+I AWLAV+V+ SF LMQL T A W ++ INV AV
Sbjct 1 MREQTREFDQHYARSAARRARLLSIAAWLAVMVSVSFVLMQLLTDAWLWPLSWINVAAAV 60
Query 86 TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH 145
FAIVP+LHRFG LVAPLTFIG AYV +FA W +GT +GAQFFFLV A LVVL++GIEH
Sbjct 61 VFAIVPMLHRFGELVAPLTFIGAAYVTVFASCWSIGTGSGAQFFFLVGACLVVLVLGIEH 120
Query 146 TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT 205
LA GLAA+A L+IA+EFLVP +TG++P WA S FV+TTVSAC V V +VWFAL DT
Sbjct 121 IVLASGLAALATALIIAVEFLVPRNTGVEPGWAQSAGFVITTVSACVVVVVSVWFALWDT 180
Query 206 ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS 265
ARAEA+MEA++DRSEALLANMLPASIAERLK PER++IADKYDEASVLFADIVGFTERAS
Sbjct 181 ARAEAIMEAQYDRSEALLANMLPASIAERLKHPERDVIADKYDEASVLFADIVGFTERAS 240
Query 266 STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALD 325
S APA+LVRFLDRLYSAFD LVD+HGLEKIKVSGD YMVVSGVPRPRPDH QALADFALD
Sbjct 241 SAAPAELVRFLDRLYSAFDALVDKHGLEKIKVSGDCYMVVSGVPRPRPDHVQALADFALD 300
Query 326 MTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQ 385
M +VAA LKDP+G VPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRME+TDSVG+
Sbjct 301 MVDVAAGLKDPQGCSVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMETTDSVGK 360
Query 386 IQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 443
IQVPDEVYE LKDDF+L+ERGHINVKGKGVMRTWYL+GRK A P + EP TAGV
Sbjct 361 IQVPDEVYELLKDDFLLQERGHINVKGKGVMRTWYLLGRKPAEQPADTLAEEPSTAGV 418
>gi|342860804|ref|ZP_08717454.1| adenylate cyclase [Mycobacterium colombiense CECT 3035]
gi|342131828|gb|EGT85085.1| adenylate cyclase [Mycobacterium colombiense CECT 3035]
Length=421
Score = 567 bits (1461), Expect = 1e-159, Method: Compositional matrix adjust.
Identities = 299/421 (72%), Positives = 341/421 (81%), Gaps = 0/421 (0%)
Query 23 VTAVRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVF 82
+ A R Q+R TQHYA+S AR RVL I AWLAV V+ +F ++Q+ TGA W I L++
Sbjct 1 MAAARAQSRDRTQHYADSAAREYRVLMIAAWLAVAVSTTFVVLQVVTGAWIWQIVLVSSA 60
Query 83 TAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVG 142
+AV FA VP LHRFG LVAPLTFIG AYV +F WD GT +GAQFF +V A LVVL++G
Sbjct 61 SAVIFACVPWLHRFGDLVAPLTFIGAAYVTVFVTCWDSGTASGAQFFLVVGACLVVLVLG 120
Query 143 IEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFAL 202
++H LA LAA+AAGL+IALEFLVP DTGL P WA S+ FV+T VSAC + TV +AL
Sbjct 121 LDHIVLAAILAAIAAGLIIALEFLVPRDTGLVPAWAQSMMFVVTIVSACVMVFITVSYAL 180
Query 203 RDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTE 262
RDT RAEAVME+E+ RSEALLANMLP SIAERLK +RN+IADKYDEASVLFADIV FTE
Sbjct 181 RDTQRAEAVMESEYARSEALLANMLPGSIAERLKSADRNVIADKYDEASVLFADIVSFTE 240
Query 263 RASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADF 322
RASST PADLVRFLDRLY AFDELVD+HGLEKIKVSGDSYMVVSGVPR RPDH ALA
Sbjct 241 RASSTTPADLVRFLDRLYGAFDELVDRHGLEKIKVSGDSYMVVSGVPRARPDHAFALAAL 300
Query 323 ALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS 382
ALDM NVAA LKDP G +PLR+G+A GPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS
Sbjct 301 ALDMANVAAALKDPHGQAIPLRMGMACGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS 360
Query 383 VGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAG 442
VG+IQVP+ +YERLK +FVL+ERG I +KGKGVMRTWYLIGRK +P ++R +PRT
Sbjct 361 VGRIQVPEAMYERLKHEFVLQERGRIEIKGKGVMRTWYLIGRKAGEEPTDLRAEDPRTVH 420
Query 443 V 443
V
Sbjct 421 V 421
>gi|254550629|ref|ZP_05141076.1| membrane-anchored adenylyl cyclase cya [Mycobacterium tuberculosis
'98-R604 INH-RIF-EM']
Length=283
Score = 556 bits (1433), Expect = 3e-156, Method: Compositional matrix adjust.
Identities = 282/283 (99%), Positives = 283/283 (100%), Gaps = 0/283 (0%)
Query 26 VRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV 85
+RTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV
Sbjct 1 MRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAV 60
Query 86 TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH 145
TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH
Sbjct 61 TFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEH 120
Query 146 TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT 205
TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT
Sbjct 121 TALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDT 180
Query 206 ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS 265
ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS
Sbjct 181 ARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERAS 240
Query 266 STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGV 308
STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGV
Sbjct 241 STAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGV 283
>gi|108799991|ref|YP_640188.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS]
gi|119869116|ref|YP_939068.1| adenylate cyclase [Mycobacterium sp. KMS]
gi|108770410|gb|ABG09132.1| adenylate/guanylate cyclase [Mycobacterium sp. MCS]
gi|119695205|gb|ABL92278.1| adenylate cyclase [Mycobacterium sp. KMS]
Length=439
Score = 507 bits (1305), Expect = 2e-141, Method: Compositional matrix adjust.
Identities = 242/409 (60%), Positives = 308/409 (76%), Gaps = 2/409 (0%)
Query 19 RPDCVTAVRTQARAP--TQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYI 76
R CV V Q+R P T+HYAE+V RR RVLTI W+A V+ F L QL G GW+I
Sbjct 8 RAVCVPDVALQSRMPARTRHYAEAVVRRLRVLTIATWIASAVSALFGLFQLVLGGSGWWI 67
Query 77 ALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAAL 136
L N+ A F +PLL+R G L+APLTF AY+++ I + +GTD+G QF++LV+A+L
Sbjct 68 GLFNIVCATLFLGIPLLYRLGELIAPLTFFVLAYLSVTFICYSIGTDSGLQFYYLVSASL 127
Query 137 VVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVA 196
VVL++GIE ++ + V +A+E VP D GL PPW ++V F+L+ VSA + A
Sbjct 128 VVLVLGIERIVMSALIVTVGLSACVAMELTVPQDRGLGPPWVLTVGFILSAVSATLMVFA 187
Query 197 TVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFAD 256
TVW+ALR+T RAE ME E+ RSE LL+N+LPAS+AERLK+P +IIAD+YD+AS+LFAD
Sbjct 188 TVWYALRETDRAERAMEDEYQRSETLLSNILPASVAERLKDPAHDIIADRYDDASILFAD 247
Query 257 IVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHT 316
I G+T+RAS T+P DLVRFLDRL++ D LVD+HGLEK+K SGDSYMVVSGVPRPR DH
Sbjct 248 IAGYTKRASDTSPTDLVRFLDRLFTDLDALVDRHGLEKVKTSGDSYMVVSGVPRPRADHV 307
Query 317 QALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASR 376
+ALA ALDM A LKDP G VP+R+GLA+GPVVAGVVG+R+FFYDVWGDAVNVA+R
Sbjct 308 EALACLALDMAEAVADLKDPLGRAVPVRIGLASGPVVAGVVGARKFFYDVWGDAVNVAAR 367
Query 377 MESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
ME+TD G+IQVP VYER+K FVL ERG ++VKGKG++ TWYL+GR+
Sbjct 368 METTDEEGRIQVPHNVYERIKHSFVLEERGDVDVKGKGLIHTWYLVGRR 416
>gi|126435620|ref|YP_001071311.1| adenylate cyclase [Mycobacterium sp. JLS]
gi|126235420|gb|ABN98820.1| adenylate cyclase [Mycobacterium sp. JLS]
Length=439
Score = 506 bits (1302), Expect = 4e-141, Method: Compositional matrix adjust.
Identities = 242/409 (60%), Positives = 307/409 (76%), Gaps = 2/409 (0%)
Query 19 RPDCVTAVRTQARAP--TQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYI 76
R CV V Q+R P T+HYAE+V RR RVLTI W+A V+ F L QL G GW+I
Sbjct 8 RAICVPEVALQSRMPARTRHYAEAVIRRLRVLTIATWIASAVSALFGLFQLVLGGSGWWI 67
Query 77 ALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAAL 136
L N+ A F +PLL+R G L+APLTF AY+++ I + +GTD+G QF++LV+A+L
Sbjct 68 GLFNIVCATLFLGIPLLYRLGELIAPLTFFVLAYLSVTFICYSIGTDSGLQFYYLVSASL 127
Query 137 VVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVA 196
VVL++GIE ++ + V +A+E VP D GL PPW ++V F+L+ VSA + A
Sbjct 128 VVLVLGIERIVMSALIVTVGLSACVAMELTVPQDRGLGPPWVLTVGFILSAVSATLMVFA 187
Query 197 TVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFAD 256
TVW+ALR+T RAE ME E+ RSE LL+N+LPAS+AERLK+P IIAD+YD+AS+LFAD
Sbjct 188 TVWYALRETDRAERAMEDEYQRSETLLSNILPASVAERLKDPAHAIIADRYDDASILFAD 247
Query 257 IVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHT 316
I G+T+RAS T+P DLVRFLDRL++ D LVD+HGLEK+K SGDSYMVVSGVPRPR DH
Sbjct 248 IAGYTKRASDTSPTDLVRFLDRLFTDLDALVDRHGLEKVKTSGDSYMVVSGVPRPRADHV 307
Query 317 QALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASR 376
+ALA ALDM A LKDP G VP+R+GLA+GPVVAGVVG+R+FFYDVWGDAVNVA+R
Sbjct 308 EALACLALDMAEAVADLKDPLGRAVPVRIGLASGPVVAGVVGARKFFYDVWGDAVNVAAR 367
Query 377 MESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
ME+TD G+IQVP VYER+K FVL ERG ++VKGKG++ TWYL+GR+
Sbjct 368 METTDEEGRIQVPHNVYERIKHSFVLEERGDVDVKGKGLIHTWYLVGRR 416
>gi|145224160|ref|YP_001134838.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK]
gi|145216646|gb|ABP46050.1| putative adenylate/guanylate cyclase [Mycobacterium gilvum PYR-GCK]
Length=396
Score = 461 bits (1187), Expect = 9e-128, Method: Compositional matrix adjust.
Identities = 226/388 (59%), Positives = 287/388 (74%), Gaps = 0/388 (0%)
Query 41 VARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLV 100
+ RRQ VL I W+A V+ +F QL G W++ +NV A+ F +P L G L+
Sbjct 1 MGRRQSVLMIAGWIAAAVSAAFGAFQLTLGGSLWWLGAVNVLCALVFLWIPRLCPLGELL 60
Query 101 APLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLV 160
APLTF+ AY+++ + +GT +G QF+FLVAA+LV+L++GIE ALA +A V +
Sbjct 61 APLTFVTFAYMSVTFFCYTIGTGSGMQFYFLVAASLVLLVLGIERVALAAVIAGVGVVIT 120
Query 161 IALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSE 220
+ LE VP D GL P W ++ F+ S+ + VAT+W+ LR+ RAE+ ME E++RSE
Sbjct 121 VVLELTVPEDRGLGPSWTLTAGFISAVTSSAVMIVATIWYTLREIERAESAMENEYERSE 180
Query 221 ALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLY 280
LLAN+LPA+IAERLKEP R +IADKYD+AS+LFADI G+T+RAS TAPA+LVRFLD LY
Sbjct 181 RLLANILPATIAERLKEPTRTVIADKYDDASILFADIAGYTKRASDTAPAELVRFLDLLY 240
Query 281 SAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNP 340
+ D LVD+HGLEK+K SGDSYMVVSGVP PRPDH +ALA ALDM+ A LKDPRG
Sbjct 241 TDLDALVDRHGLEKVKTSGDSYMVVSGVPTPRPDHLEALATLALDMSEAVADLKDPRGRD 300
Query 341 VPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDF 400
VPLR+G+A GPVVAGVVG+++FFYDVWGDAVNVASRME+TD G+IQVPD VY+RL+ F
Sbjct 301 VPLRIGMAMGPVVAGVVGAKKFFYDVWGDAVNVASRMETTDEEGRIQVPDNVYQRLRHAF 360
Query 401 VLRERGHINVKGKGVMRTWYLIGRKVAA 428
VL ERG I+VKGKG M TWYL+G + A
Sbjct 361 VLEERGLIDVKGKGPMHTWYLVGHRARA 388
>gi|333990763|ref|YP_004523377.1| membrane-anchored adenylyl cyclase Cya_1 [Mycobacterium sp. JDM601]
gi|333486731|gb|AEF36123.1| membrane-anchored adenylyl cyclase Cya_1 [Mycobacterium sp. JDM601]
Length=435
Score = 454 bits (1168), Expect = 1e-125, Method: Compositional matrix adjust.
Identities = 225/412 (55%), Positives = 291/412 (71%), Gaps = 4/412 (0%)
Query 32 APTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVP 91
A T+HYA +++R R+L ++A LA +++ F L+++ W+I +N+ A F + P
Sbjct 25 ARTRHYAARLSQRLRILKVSAGLAAIISAGFGLLEIWADPAYWWIGALNLIAAAAFVLTP 84
Query 92 LLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVG 151
LL+ +G L+APL F+G AY+ F I W VGT +G QF+FL +A++ VL++G++ LA
Sbjct 85 LLYHYGELIAPLAFVGIAYLTTFVICWVVGTGSGVQFYFLASASISVLILGVDRIKLAAV 144
Query 152 LAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAV 211
+A + A L IAL+ LVP QP W +SF L VSAC + +AT+W+ALR+ AEA
Sbjct 145 VAGIGAALTIALQLLVPTYKLDQPAWLRDLSFALVVVSACFIVIATIWYALREIGHAEAA 204
Query 212 MEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPAD 271
MEAE+DRSEALLAN+LP ++A+RLK P ++IAD Y +ASVLFADI FT RAS T P
Sbjct 205 MEAEYDRSEALLANILPTAVADRLKNPAVDVIADSYPDASVLFADIADFTRRASQTDPGQ 264
Query 272 LVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAA 331
LV FL+ +Y+ D LVD+HGLEKIK SGDSYMVVSGVP PRPDH ALA ALD+ A
Sbjct 265 LVEFLNEIYTGLDRLVDRHGLEKIKTSGDSYMVVSGVPDPRPDHLHALAQLALDIAGTIA 324
Query 332 QLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDE 391
+L+DP G PV LR+GLA GPVVAGVVG+RRFFYDVWGDAVN+ASRMEST +IQVP +
Sbjct 325 ELRDPLGRPVSLRIGLAAGPVVAGVVGNRRFFYDVWGDAVNLASRMESTGVPNRIQVPQD 384
Query 392 VYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAADPGEVRGAEPRTAGV 443
VYERL +FV ERG ++VKGKGVM TW+L+G A P RG R+ V
Sbjct 385 VYERLTSEFVFEERGDVDVKGKGVMHTWFLVG----ARPPASRGPASRSLSV 432
>gi|315444495|ref|YP_004077374.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1]
gi|315262798|gb|ADT99539.1| family 3 adenylate cyclase [Mycobacterium sp. Spyr1]
Length=388
Score = 451 bits (1161), Expect = 1e-124, Method: Compositional matrix adjust.
Identities = 220/379 (59%), Positives = 281/379 (75%), Gaps = 0/379 (0%)
Query 50 ITAWLAVVVTGSFALMQLATGAGGWYIALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTA 109
I W+A V+ +F QL G W++ +NV A+ F +P L G L+APLTF+ A
Sbjct 2 IAGWIAAAVSAAFGAFQLTLGGSLWWLGAVNVLCALVFLWIPRLCPLGELLAPLTFVTFA 61
Query 110 YVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPP 169
Y+++ + +GT +G QF+FLVAA+LV+L++GIE ALA +A + + + LE VP
Sbjct 62 YMSVTFFCYTIGTGSGMQFYFLVAASLVLLVLGIERVALAAVIAGIGVVITVVLELTVPE 121
Query 170 DTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPA 229
D GL P W ++ F+ S+ + VAT+W+ LR+ RAE+ ME E++RSE LLAN+LPA
Sbjct 122 DRGLGPSWTLTAGFISAVTSSAVMIVATIWYTLREIERAESAMENEYERSERLLANILPA 181
Query 230 SIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQ 289
+IAERLKEP R +IADKYD+AS+LFADI G+T+RAS TAPA+LVRFLD LY+ D LVD+
Sbjct 182 TIAERLKEPTRTVIADKYDDASILFADIAGYTKRASDTAPAELVRFLDLLYTDLDALVDR 241
Query 290 HGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLAT 349
HGLEK+K SGDSYMVVSGVP PRPDH +ALA ALDM+ A LKDPRG VPLR+G+A
Sbjct 242 HGLEKVKTSGDSYMVVSGVPTPRPDHLEALATLALDMSEAVADLKDPRGRDVPLRIGMAM 301
Query 350 GPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHIN 409
GPVVAGVVG+++FFYDVWGDAVNVASRME+TD G+IQVPD VY+RL+ FVL ERG I+
Sbjct 302 GPVVAGVVGAKKFFYDVWGDAVNVASRMETTDEEGRIQVPDNVYQRLRHAFVLEERGLID 361
Query 410 VKGKGVMRTWYLIGRKVAA 428
VKGKG M TWYL+G + A
Sbjct 362 VKGKGPMHTWYLVGHRARA 380
>gi|88191822|pdb|1YK9|A Chain A, Crystal Structure Of A Mutant Form Of The Mycobacterial
Adenylyl Cyclase Rv1625c
Length=204
Score = 407 bits (1046), Expect = 2e-111, Method: Compositional matrix adjust.
Identities = 201/204 (99%), Positives = 202/204 (99%), Gaps = 0/204 (0%)
Query 240 RNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSG 299
RNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKI+VSG
Sbjct 1 RNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIEVSG 60
Query 300 DSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGS 359
DSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGS
Sbjct 61 DSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGS 120
Query 360 RRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTW 419
RRF Y VWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTW
Sbjct 121 RRFRYCVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTW 180
Query 420 YLIGRKVAADPGEVRGAEPRTAGV 443
YLIGRKVAADPGEVRGAEPRTAGV
Sbjct 181 YLIGRKVAADPGEVRGAEPRTAGV 204
>gi|120403823|ref|YP_953652.1| putative adenylate/guanylate cyclase [Mycobacterium vanbaalenii
PYR-1]
gi|119956641|gb|ABM13646.1| adenylate cyclase [Mycobacterium vanbaalenii PYR-1]
Length=421
Score = 405 bits (1041), Expect = 7e-111, Method: Compositional matrix adjust.
Identities = 238/412 (58%), Positives = 302/412 (74%), Gaps = 2/412 (0%)
Query 19 RPDCVTAVRTQARA--PTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYI 76
RP CV V RA P++H E VARRQRVL I +W+A + F + QL G W++
Sbjct 2 RPVCVPEVTLGRRAWSPSRHRHERVARRQRVLMIASWIAAAASVGFGVFQLTFGGPLWWL 61
Query 77 ALINVFTAVTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAAL 136
+N+ V F +P L G L+APLTF+ AY ++ I + +GT +G QF+FLVAA+L
Sbjct 62 GAVNIGCGVVFLAIPRLCPLGELIAPLTFVVFAYTSVGFICYTIGTGSGLQFYFLVAASL 121
Query 137 VVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVA 196
VVL++GIE ALA +AA + I LE VP D GL P W ++ F+ VS+ + VA
Sbjct 122 VVLVLGIERIALAAAIAAAGVIITIVLELTVPDDRGLGPSWTLTAGFISAVVSSVVIIVA 181
Query 197 TVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFAD 256
T+W+ LR+ RAEA M AE++RSE LLAN+LPA+IA+RLKEP R +IADKYD+AS+LFAD
Sbjct 182 TIWYTLREIDRAEAAMAAEYERSEELLANILPATIADRLKEPTRTVIADKYDDASILFAD 241
Query 257 IVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHT 316
I G+T+RAS T P++LVRFLDRLY+ D LVD+HGLEK+K SGDSYMVVSGVP PR DH
Sbjct 242 IAGYTKRASETPPSELVRFLDRLYTDLDALVDRHGLEKVKTSGDSYMVVSGVPNPRADHL 301
Query 317 QALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASR 376
+ALA ALDM + A LKDP+G+ VPLR+G+A+GPVVAGVVG+++FFYDVWGDAVNVASR
Sbjct 302 EALALLALDMADAVADLKDPQGHDVPLRIGMASGPVVAGVVGAKKFFYDVWGDAVNVASR 361
Query 377 MESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAA 428
ME+TD G+IQVPD VYERL+D FVL ERG ++VKGKG M TWYL+ + A
Sbjct 362 METTDVEGRIQVPDNVYERLRDRFVLEERGVVDVKGKGPMHTWYLVAHRAEA 413
>gi|183980691|ref|YP_001848982.1| membrane-anchored adenylyl cyclase Cya_1 [Mycobacterium marinum
M]
gi|183174017|gb|ACC39127.1| membrane-anchored adenylyl cyclase Cya_1 [Mycobacterium marinum
M]
Length=441
Score = 393 bits (1009), Expect = 4e-107, Method: Compositional matrix adjust.
Identities = 192/394 (49%), Positives = 269/394 (69%), Gaps = 3/394 (0%)
Query 35 QHYAESVARRQRVLTITAWLAVVVTGSFALMQ-LATGAGGWYIALINVFTAVTFAIVPLL 93
+ YA+S+ RR+RV+ I A A VV+ SFA+++ LAT WY+ +N AV FA++PLL
Sbjct 36 RQYADSLTRRRRVVAIVACTASVVSASFAVIEVLATSQ--WYVVSLNAVMAVVFAVIPLL 93
Query 94 HRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIEHTALAVGLA 153
+R G LV L + A V++ + W + + G F+FL++ + L++GI+H LA +
Sbjct 94 YRLGELVPALALVIAANVSLVVVSWMIDSHVGIAFYFLMSVLVAALVLGIDHLMLAAAVV 153
Query 154 AVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVME 213
+ IA + P P WA F +TT+SA V +AT+W+AL + RA+ +E
Sbjct 154 TFGVVINIAARVVAPFHARKMPVWATDAGFAVTTISASVVVMATIWYALNEIERAKEAIE 213
Query 214 AEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLV 273
E++R+E+LL N+LPAS+A RLK+P IIAD YD+ S+LFADI G+TERAS +LV
Sbjct 214 LEYERAESLLTNILPASVAARLKDPATKIIADNYDDVSILFADIAGYTERASRATAEELV 273
Query 274 RFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQL 333
+FL+R Y D+LV++HGLEK+K SGD Y+VVSGVP+P+ DH +ALA FAL +++ L
Sbjct 274 KFLNRFYGECDDLVERHGLEKVKTSGDCYIVVSGVPQPKSDHLEALARFALSLSDSVGHL 333
Query 334 KDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVY 393
D G V +R+GLA GPVVAGVVG+ RFFYDVWGD VNVA+RMEST G+IQVP +VY
Sbjct 334 TDHTGETVSIRIGLAAGPVVAGVVGTSRFFYDVWGDPVNVAARMESTGFPGRIQVPQDVY 393
Query 394 ERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVA 427
ERL++ FV ERG + VKGKG++ TW+L+G + +
Sbjct 394 ERLRERFVFEERGTVAVKGKGMLHTWFLVGERTS 427
>gi|54124771|gb|AAV30109.1| Cya1625 [Mycobacterium smegmatis str. MC2 155]
Length=369
Score = 338 bits (867), Expect = 1e-90, Method: Compositional matrix adjust.
Identities = 177/256 (70%), Positives = 205/256 (81%), Gaps = 0/256 (0%)
Query 170 DTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPA 229
D GL P W +SV FV++TVSA + VATVW ALR+ ARAE MEAE+ RSE LLAN+LPA
Sbjct 91 DRGLGPHWTLSVGFVISTVSAAVMVVATVWSALREIARAEDAMEAEYQRSEKLLANILPA 150
Query 230 SIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQ 289
+IA RLK+P R IIAD+YD+AS+LFADI G+T+RAS TAP DLVRFLD LY+ D LV+Q
Sbjct 151 TIATRLKDPARTIIADRYDDASILFADIAGYTKRASETAPCDLVRFLDTLYTDLDALVEQ 210
Query 290 HGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLAT 349
H LEK+K SGDSYMVV G+P PR DH +ALA ALDM A L DP G VPLR+GLA
Sbjct 211 HCLEKVKTSGDSYMVVGGIPEPRTDHAEALAALALDMAAAVADLTDPEGRRVPLRIGLAA 270
Query 350 GPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHIN 409
GPVVAGVVG+RRFFYDVWGDAVNVASRMESTD G+IQVPD++ RL+ FVL ERG +
Sbjct 271 GPVVAGVVGARRFFYDVWGDAVNVASRMESTDVEGRIQVPDDMCLRLRHAFVLEERGEVE 330
Query 410 VKGKGVMRTWYLIGRK 425
VKGKGVMRTWYL+GR+
Sbjct 331 VKGKGVMRTWYLVGRR 346
>gi|334116607|ref|ZP_08490699.1| adenylate/guanylate cyclase with integral membrane sensor [Microcoleus
vaginatus FGP-2]
gi|333461427|gb|EGK90032.1| adenylate/guanylate cyclase with integral membrane sensor [Microcoleus
vaginatus FGP-2]
Length=470
Score = 249 bits (636), Expect = 6e-64, Method: Compositional matrix adjust.
Identities = 119/229 (52%), Positives = 166/229 (73%), Gaps = 1/229 (0%)
Query 198 VWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADI 257
V+ + +AE V+ AE ++SE LL N+LPA IA+RLK+ + NI AD + E +VLFADI
Sbjct 243 VYKEIAQRKQAEEVLRAEQEKSERLLLNILPAMIADRLKQGQINI-ADGFAEVTVLFADI 301
Query 258 VGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQ 317
VGFTE +S T+P +LV L++++SAFD L +Q+GLEKIK GD+YMV G+P P +H +
Sbjct 302 VGFTEISSRTSPEELVELLNKIFSAFDRLSEQYGLEKIKTIGDNYMVAGGLPLPCTNHAE 361
Query 318 ALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRM 377
++A+ AL+M + +D G P+ +R+G+ TGPVVAGV+G+++F YD+WGDAVN ASRM
Sbjct 362 SIAEMALEMQQEIMKFRDECGKPLNIRIGINTGPVVAGVIGTKKFIYDLWGDAVNTASRM 421
Query 378 ESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKV 426
ES G+IQV + YE L D ++L +RG INVKGKG M T+ L GRK+
Sbjct 422 ESQGLPGKIQVSNSTYELLCDKYLLEKRGKINVKGKGSMTTYLLKGRKL 470
>gi|332706561|ref|ZP_08426622.1| PAS domain S-box protein [Lyngbya majuscula 3L]
gi|332354445|gb|EGJ33924.1| PAS domain S-box protein [Lyngbya majuscula 3L]
Length=1398
Score = 249 bits (636), Expect = 6e-64, Method: Composition-based stats.
Identities = 117/219 (54%), Positives = 162/219 (74%), Gaps = 1/219 (0%)
Query 207 RAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASS 266
+AEA + AE ++SE LL N+LP SIA+RLK+ E IA+++DE ++LFADIV FT+ ++
Sbjct 1181 QAEAALRAEQEKSEHLLLNILPHSIAQRLKQ-EPKAIANRFDEVTILFADIVEFTKLSAR 1239
Query 267 TAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDM 326
+P +LV L++++S+FD+L HGLEKIK GD+YMVV G+P PR DH +A+A+ ALD+
Sbjct 1240 ISPTELVNLLNQIFSSFDQLAQHHGLEKIKTIGDAYMVVGGLPNPRDDHPEAIANMALDL 1299
Query 327 TNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQI 386
++ + G P LR+G+ TGPVVAGV+G ++F YD+WGDAVNVASRM+S G+I
Sbjct 1300 QQEISRFQRHDGEPFRLRIGINTGPVVAGVIGIQKFIYDLWGDAVNVASRMDSQGEPGRI 1359
Query 387 QVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
QV YERL+D ++ ERG INVKGKG M T++L GRK
Sbjct 1360 QVTANTYERLRDKYLFEERGIINVKGKGEMITYWLTGRK 1398
>gi|254412328|ref|ZP_05026102.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
gi|196180638|gb|EDX75628.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
Length=1086
Score = 241 bits (616), Expect = 1e-61, Method: Compositional matrix adjust.
Identities = 113/230 (50%), Positives = 163/230 (71%), Gaps = 3/230 (1%)
Query 196 ATVWFA--LRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVL 253
+ +W A + D +AE + E ++SE LL N+LP IAERLK+ +++ IA+ +D+ ++L
Sbjct 856 SVIWVARDITDRKQAEVALRLEQEKSEQLLLNILPELIAERLKQ-DQSAIAENFDDVTIL 914
Query 254 FADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRP 313
FADIVGFT ++ P +LV L++++S FD+L ++HGLEKIK GD+YMVV G+P+PR
Sbjct 915 FADIVGFTPLSARLKPIELVNLLNQMFSTFDQLAERHGLEKIKTIGDAYMVVGGLPQPRG 974
Query 314 DHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNV 373
DH +A+A ALDM Q + + +R+G+ TG VVAGV+G R+F YD+WGDAVNV
Sbjct 975 DHAEAIAQMALDMQQAITQFQAEHSESLQIRIGINTGSVVAGVIGIRKFIYDLWGDAVNV 1034
Query 374 ASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIG 423
ASRMES+ G+IQV + Y+RL+D F +ERG I VKG+G M T++L+G
Sbjct 1035 ASRMESSGEPGKIQVTETTYQRLRDKFQFQERGAIAVKGRGEMTTYWLMG 1084
>gi|300024217|ref|YP_003756828.1| adenylate/guanylate cyclase [Hyphomicrobium denitrificans ATCC
51888]
gi|299526038|gb|ADJ24507.1| adenylate/guanylate cyclase [Hyphomicrobium denitrificans ATCC
51888]
Length=442
Score = 240 bits (613), Expect = 3e-61, Method: Compositional matrix adjust.
Identities = 145/396 (37%), Positives = 212/396 (54%), Gaps = 14/396 (3%)
Query 35 QHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWY-IALINVFTAVTFAIVPLL 93
+ Y RR +++ + ++L VV T +A+ +G + IN+ AV + VPL+
Sbjct 48 KDYPPDTQRRLKIVNVFSFLVVVTTFIYAIQLWMSGDETMMPVVFINLALAVILSFVPLM 107
Query 94 HRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAA--LVVLLVGIEHTALAVG 151
HRF + L + + A+ G GA ++VAAA V+ +
Sbjct 108 HRFNEMAGGLLLVVAEFSALIGFTSYFGRLGGAPLQYVVAAAAPFVIFEARRFWLVFVIV 167
Query 152 LAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFA--LRDTARAE 209
++A+ L+ +F + + +V ++ G+ A V++A L +TA+AE
Sbjct 168 VSALVLHLIAWFQFPMEAARLHADQKVIDSLYVQGAITTFGLIAACVYYAFGLVETAKAE 227
Query 210 AVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAP 269
+E +L N+LP +I ERLK IAD + EASVLFADI GF A P
Sbjct 228 ---------TETVLRNILPDAIVERLKMAPGQTIADGFTEASVLFADISGFVRLARGLGP 278
Query 270 ADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNV 329
V L+RL +AFDEL QHG+EKIK GD+YMV SGVP PRPDH QALA ALD+
Sbjct 279 EKTVALLNRLVTAFDELAQQHGVEKIKTIGDAYMVASGVPVPRPDHAQALAAMALDLVAT 338
Query 330 AAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVP 389
+ + +R+G+A GP+ AG++G +F YDVWGD VN+ASR+E + VG+I +
Sbjct 339 VRTIAADENIDLNVRIGIAAGPMTAGIIGKNKFSYDVWGDPVNMASRLEQSSEVGRITIC 398
Query 390 DEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
Y LK+ F+LR RG I++KG G W+L GR+
Sbjct 399 PTCYAALKESFILRPRGLIDIKGVGEQEAWFLDGRR 434
>gi|119486420|ref|ZP_01620478.1| adenylate cyclase [Lyngbya sp. PCC 8106]
gi|119456322|gb|EAW37453.1| adenylate cyclase [Lyngbya sp. PCC 8106]
Length=545
Score = 239 bits (611), Expect = 6e-61, Method: Compositional matrix adjust.
Identities = 111/241 (47%), Positives = 163/241 (68%), Gaps = 6/241 (2%)
Query 184 VLTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLK-EPERNI 242
+L++V A +W + + + +E E ++SE LL N+LP SIA RLK +PE
Sbjct 308 LLSSVIAMVTLSVVIWRSFQSALKQ---LEVEQEKSERLLLNILPESIALRLKNKPE--T 362
Query 243 IADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSY 302
IAD ++E +VLFADI GFT+ ++ +P +LV L+ ++S FD++ Q+ LEKIK GD+Y
Sbjct 363 IADNFEEVTVLFADIAGFTQLSAKISPTELVNLLNEIFSEFDQITTQNNLEKIKTIGDAY 422
Query 303 MVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRF 362
+VV G+P PR DH +A+A AL+M N + + + LR+G+ TGPVVAGV+G+++F
Sbjct 423 LVVGGLPNPRSDHAEAIAKLALEMQNKLIEFNQKHDHNLQLRIGINTGPVVAGVIGAKKF 482
Query 363 FYDVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLI 422
YD+WGD VN+ASRMES +G+IQV + Y+RL+D + +RG INVKGKG M T++L
Sbjct 483 IYDLWGDTVNIASRMESHGIIGEIQVTEATYQRLQDKYKFEKRGLINVKGKGEMSTYFLK 542
Query 423 G 423
G
Sbjct 543 G 543
>gi|300866069|ref|ZP_07110799.1| Adenylate and Guanylate cyclase catalytic domain protein [Oscillatoria
sp. PCC 6506]
gi|300335930|emb|CBN55957.1| Adenylate and Guanylate cyclase catalytic domain protein [Oscillatoria
sp. PCC 6506]
Length=470
Score = 239 bits (610), Expect = 6e-61, Method: Compositional matrix adjust.
Identities = 113/229 (50%), Positives = 161/229 (71%), Gaps = 1/229 (0%)
Query 198 VWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADI 257
V+ + +AE ++ +E ++SE LL N+LP IAERLK+ + NI AD + + ++LFADI
Sbjct 243 VYQEINQRKKAEEILRSEQEKSERLLLNILPEPIAERLKQGQSNI-ADGFADVTILFADI 301
Query 258 VGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQ 317
VGFTE +S +P +LV L++++SAFDEL +++ LEKIK GD+YMV +G+P P PDH +
Sbjct 302 VGFTEISSRVSPQELVDLLNKIFSAFDELSEKYCLEKIKTIGDNYMVAAGLPVPHPDHAE 361
Query 318 ALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRM 377
A+A+ ALDM + G P+ +R+G+ +GPVVAGV+G+++F YD+WGDAVN ASRM
Sbjct 362 AIAEMALDMQQEIVRFSIECGKPLNIRIGINSGPVVAGVIGTKKFIYDLWGDAVNTASRM 421
Query 378 ESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKV 426
ES G+IQV Y L++ ++ ERG I VKGKG M T+ L GRKV
Sbjct 422 ESQGIPGKIQVSASTYYLLQNKYLFEERGIIQVKGKGEMTTYLLTGRKV 470
>gi|119484312|ref|ZP_01618929.1| adenylate cyclase [Lyngbya sp. PCC 8106]
gi|119457786|gb|EAW38909.1| adenylate cyclase [Lyngbya sp. PCC 8106]
Length=358
Score = 238 bits (608), Expect = 1e-60, Method: Compositional matrix adjust.
Identities = 128/310 (42%), Positives = 191/310 (62%), Gaps = 14/310 (4%)
Query 130 FLVAAALVVLLVGIEHTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSF-----V 184
F+V ++VL + L + L +AAG I +PP S S +
Sbjct 57 FVVIGTMIVLEKMVITPILNLRLDLIAAGKSIY--------KNQEPPKFYSASTQRHDEL 108
Query 185 LTTVSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIA 244
+SA + A+ + +AE + E ++SE LL N+LP +IAE+LK+ + +IA
Sbjct 109 GDVISAFIQMFTQIHQAITERQQAEDALRVEKEKSEQLLLNILPQAIAEQLKK-QPGLIA 167
Query 245 DKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMV 304
D++++A++LFADI FT AS +P +LV L++++S+FD L ++HGLEKIK GD+YMV
Sbjct 168 DRFEQATILFADITDFTGLASQISPTELVSLLNQIFSSFDRLAERHGLEKIKTIGDAYMV 227
Query 305 VSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFY 364
V G+P+PR DH +A+AD ALDM + K + +R+G+ TGPVVAGV+G ++F Y
Sbjct 228 VGGLPKPRTDHAEAIADMALDMQQEIYRFKREDNKILNIRIGINTGPVVAGVIGLKKFSY 287
Query 365 DVWGDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGR 424
D+WGDAVN+ASRMES +G+IQV YE LK +VL +RG + VKG+G M T++L R
Sbjct 288 DLWGDAVNIASRMESHGKIGEIQVSSSTYELLKHKYVLEKRGIVQVKGRGEMITYWLKSR 347
Query 425 KVAADPGEVR 434
+ A +V+
Sbjct 348 QPTAVESQVK 357
>gi|300865804|ref|ZP_07110557.1| Adenylate/guanylate cyclase [Oscillatoria sp. PCC 6506]
gi|300336198|emb|CBN55712.1| Adenylate/guanylate cyclase [Oscillatoria sp. PCC 6506]
Length=435
Score = 238 bits (606), Expect = 2e-60, Method: Compositional matrix adjust.
Identities = 125/277 (46%), Positives = 169/277 (62%), Gaps = 2/277 (0%)
Query 145 HTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVSFVLTTVSACGVAVATVWFALRD 204
H +G+ G+ AL V P+ P AM ++ C ++V +
Sbjct 157 HLTAQLGVFVYYFGVNAALNLQVKPEDMPVAP-AMLYLYLFWACVTCNLSVYLYERLAKA 215
Query 205 TARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERA 264
+A +EAE DRSE LL N+LP IAERLK+ + I AD + E SVLFADIVGFTE +
Sbjct 216 EFKARRALEAEKDRSERLLLNILPPPIAERLKQDPQTI-ADSFAEVSVLFADIVGFTELS 274
Query 265 SSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFAL 324
+ +P +LV+ L+ ++S FD LV++HGLEKIK GD+YMVV G+P DH A+A+ L
Sbjct 275 ARISPTELVKLLNEIFSMFDHLVERHGLEKIKTIGDAYMVVGGLPENHLDHAHAIAEMGL 334
Query 325 DMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVG 384
DM AQ +G +R+G++TG VVAGV+G ++F YD+WGD VN ASRMES G
Sbjct 335 DMQQALAQFNAKKGQDFQIRIGISTGLVVAGVIGWKKFAYDLWGDTVNTASRMESHGIPG 394
Query 385 QIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYL 421
+IQV + YERLK +V ERG I +KGKG M+ + L
Sbjct 395 RIQVSESTYERLKGVYVFEERGEIEIKGKGRMKAYLL 431
>gi|254413152|ref|ZP_05026924.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
gi|196180316|gb|EDX75308.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
Length=624
Score = 237 bits (604), Expect = 3e-60, Method: Compositional matrix adjust.
Identities = 110/216 (51%), Positives = 154/216 (72%), Gaps = 1/216 (0%)
Query 209 EAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTA 268
+ + E ++ E LL N+LP IA+RLK+ E + IAD ++E +VLFADIVGFTE ++
Sbjct 408 QEALHYEQEQGERLLLNILPKVIAQRLKQLE-STIADNFEEVTVLFADIVGFTELSARFP 466
Query 269 PADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTN 328
PA +V L+R++SAFDEL D +GLEKIK GD+YMVV G+P PRPDH +A A+ ALDM
Sbjct 467 PAQVVELLNRIFSAFDELSDYYGLEKIKTIGDAYMVVGGLPTPRPDHAEATANMALDMQQ 526
Query 329 VAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQV 388
V + + + +R+G+ TGPVVAGV+G ++F YD+WGD VN+ASRMES +IQV
Sbjct 527 VITKFNNQNNQTLSIRIGINTGPVVAGVIGIKKFSYDLWGDTVNIASRMESQGLPDKIQV 586
Query 389 PDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGR 424
+ Y++L+D+++ ERG I VKGKG M T++L G+
Sbjct 587 TEFTYKKLQDNYLFEERGTIQVKGKGKMTTYFLKGK 622
>gi|254414359|ref|ZP_05028126.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
gi|196179034|gb|EDX74031.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
Length=830
Score = 236 bits (603), Expect = 4e-60, Method: Compositional matrix adjust.
Identities = 112/232 (49%), Positives = 161/232 (70%), Gaps = 3/232 (1%)
Query 196 ATVWFA--LRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVL 253
+ +W A + D +AEA ++ E D+SE LL N+LP IA RLK+ +R IA+ +D+ ++L
Sbjct 599 SVIWVARDITDRKQAEAALQLEQDKSERLLLNILPELIANRLKQDQR-AIAEHFDQVTIL 657
Query 254 FADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRP 313
FADIVGFT ++ P +LV L++++S FD+L DQ+GLEKIK GD+YMVV G+PRP
Sbjct 658 FADIVGFTPLSARLQPIELVNMLNQIFSTFDQLADQYGLEKIKTIGDAYMVVGGLPRPLD 717
Query 314 DHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNV 373
DH A+A ALDM + + +G +R+G+ TG VVAGV+G ++F YD+WGDAVNV
Sbjct 718 DHATAIAQMALDMQQAIHEFQVQQGESFEIRIGINTGSVVAGVIGRKKFIYDLWGDAVNV 777
Query 374 ASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
ASRMES+ G+IQV Y++L+ F+ +RG + VKGKG M T++L+ R+
Sbjct 778 ASRMESSGEPGKIQVTATTYQQLQHKFIFEQRGAVKVKGKGDMITYWLLSRR 829
>gi|254412114|ref|ZP_05025889.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
gi|196181080|gb|EDX76069.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
Length=655
Score = 236 bits (602), Expect = 7e-60, Method: Compositional matrix adjust.
Identities = 115/219 (53%), Positives = 152/219 (70%), Gaps = 1/219 (0%)
Query 207 RAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASS 266
+AEA + E ++SE LL N+LP I +RLK E IIA+ + E SVLFADIVGFT+ +SS
Sbjct 438 QAEAALRQEQEKSEQLLLNILPEPIVDRLKH-EHQIIAEDFAEVSVLFADIVGFTQLSSS 496
Query 267 TAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDM 326
P L+ L++++S FDEL +QH LEKIK GD+YMVV G+PR +H A+A ALDM
Sbjct 497 MPPITLLNLLNQIFSIFDELCEQHQLEKIKTIGDAYMVVGGLPRSPLNHAHAIARMALDM 556
Query 327 TNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQI 386
AQ +D G +R+G+ TGPVVAGV+G ++F YD+WGD VN+ASRMES G+I
Sbjct 557 QAAIAQFRDQTGQAFNMRIGINTGPVVAGVIGLKKFSYDLWGDTVNIASRMESQSIPGRI 616
Query 387 QVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
QV +YE+LKD F +RG I+VKG+G M T++LI K
Sbjct 617 QVTAAIYEKLKDTFEFEQRGMIDVKGRGKMTTYFLIAVK 655
>gi|254413324|ref|ZP_05027095.1| Adenylate and Guanylate cyclase catalytic domain protein [Microcoleus
chthonoplastes PCC 7420]
gi|196179944|gb|EDX74937.1| Adenylate and Guanylate cyclase catalytic domain protein [Microcoleus
chthonoplastes PCC 7420]
Length=553
Score = 235 bits (600), Expect = 1e-59, Method: Compositional matrix adjust.
Identities = 116/223 (53%), Positives = 152/223 (69%), Gaps = 1/223 (0%)
Query 203 RDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTE 262
R A A ++ E +SE LL N+LP IA RLK ER I AD ++E +VLFADIVGFTE
Sbjct 321 RQFASALTTLDRETAKSEHLLLNVLPEPIAHRLKREERTI-ADHFNEVTVLFADIVGFTE 379
Query 263 RASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADF 322
AS T+P +LV L+ ++S FD+LV++H LEKIK GD+YMVV G+P P +HT+A+AD
Sbjct 380 LASHTSPIELVEILNVIFSEFDQLVEEHHLEKIKTIGDAYMVVGGLPMPMLNHTEAIADM 439
Query 323 ALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS 382
ALDM V Q G +R+G+ TGPV+AG++G ++F YD+WGD VN+ASRMES
Sbjct 440 ALDMQRVIEQFCQETGKSFSIRIGIHTGPVIAGIIGIKKFIYDLWGDTVNIASRMESHGL 499
Query 383 VGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
G IQV ++ Y+RLK + +RG I VKGKG M + L GRK
Sbjct 500 PGSIQVTEDTYKRLKHRYHFEDRGPIQVKGKGQMNCYLLTGRK 542
>gi|119487004|ref|ZP_01620876.1| two-component hybrid sensor and regulator [Lyngbya sp. PCC 8106]
gi|119455933|gb|EAW37067.1| two-component hybrid sensor and regulator [Lyngbya sp. PCC 8106]
Length=355
Score = 235 bits (599), Expect = 1e-59, Method: Compositional matrix adjust.
Identities = 114/225 (51%), Positives = 155/225 (69%), Gaps = 2/225 (0%)
Query 202 LRDTARAE-AVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGF 260
LRD RA + E ++SE LL N+LP +IAERLK E + IAD +D+ +VLF DI F
Sbjct 130 LRDQERAYLKKLAEEQEKSEQLLLNILPKAIAERLKRGE-STIADSFDDVTVLFGDIANF 188
Query 261 TERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALA 320
T ++ +PA LV L+R++S FDEL D++ LEKIK GD+YMVV G+P P+ +H A+A
Sbjct 189 TNLSADLSPAQLVEILNRIFSLFDELADKYNLEKIKTLGDAYMVVGGLPIPQANHASAIA 248
Query 321 DFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMEST 380
+ AL+M ++ Q G P+ +R+G+ TGPV AGV+G ++F YD+WGD VN A+RMES
Sbjct 249 EMALEMQSIIGQFSLKEGEPLQMRIGINTGPVEAGVIGMKKFTYDLWGDTVNTANRMESH 308
Query 381 DSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
G+IQV YERLK+ ++L ERG I VKGKG M T++L GRK
Sbjct 309 GISGKIQVTAITYERLKEKYLLEERGKITVKGKGEMITYFLTGRK 353
>gi|119489014|ref|ZP_01621949.1| Extracellular ligand-binding receptor [Lyngbya sp. PCC 8106]
gi|119454970|gb|EAW36113.1| Extracellular ligand-binding receptor [Lyngbya sp. PCC 8106]
Length=1301
Score = 234 bits (597), Expect = 2e-59, Method: Compositional matrix adjust.
Identities = 118/231 (52%), Positives = 159/231 (69%), Gaps = 5/231 (2%)
Query 198 VWFALRDTARAEAVMEA---EHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLF 254
+W A R+T V++A E +SE LL N+LP SIAERLK+ +I A+++D A+++F
Sbjct 1073 IWVA-RNTTERRRVLDALRIEQQKSERLLQNILPRSIAERLKQAPHSI-AERFDHATIMF 1130
Query 255 ADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPD 314
ADIV FT +S AP +LV L+ ++SAFD +H LEKIK GDSYMVV G+P P+ D
Sbjct 1131 ADIVDFTGFSSQIAPTELVDLLNEIFSAFDAFAQKHDLEKIKTIGDSYMVVGGLPTPKDD 1190
Query 315 HTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVA 374
H +A+A+ ALDM + + G P LR+G+ TGPVVAGV+G+R+F YD+WGDAVNVA
Sbjct 1191 HVKAIAEMALDMQREICRFQRHDGLPFRLRIGINTGPVVAGVIGTRKFIYDLWGDAVNVA 1250
Query 375 SRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
SRMES G+IQV Y+ LKD ++ +RG I+VKG G M T++L GRK
Sbjct 1251 SRMESHGEAGKIQVTKATYDLLKDQYIFEKRGIIDVKGIGRMATYWLQGRK 1301
>gi|291567024|dbj|BAI89296.1| putative ABC transporter substrate-binding protein [Arthrospira
platensis NIES-39]
Length=1330
Score = 234 bits (596), Expect = 3e-59, Method: Composition-based stats.
Identities = 126/282 (45%), Positives = 176/282 (63%), Gaps = 12/282 (4%)
Query 155 VAAGLVIALEF---LVPPDTGLQPP-----WAMSVSFVLTTVSACGVAVATVWFALRDTA 206
+ G I LE+ L PP+ G Q P A V + + +V + R+T
Sbjct 1050 IQTGETINLEYSMQLAPPEPGQQGPVNILPSATDADLVWFAATVSPMPDNSVIWVARNTT 1109
Query 207 RAEAVMEA---EHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTER 263
V++A E +SE LL N+LP SIAERLK+ +I A+++D+A+V+FAD+V FT
Sbjct 1110 ERRRVLDALRVEQQKSERLLLNILPRSIAERLKQSPHSI-AERFDQATVMFADLVNFTGF 1168
Query 264 ASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFA 323
++ +P +LV L+ ++S FDEL +H LEKIK GDSYMVV G+P P +H +A+A A
Sbjct 1169 SAQISPTELVDLLNDIFSCFDELAQKHQLEKIKTIGDSYMVVGGLPTPVENHAEAIAHMA 1228
Query 324 LDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSV 383
LDM + + G P LR+G+ TGPVVAGV+G+R+F YD+WGDAVNVASRMES V
Sbjct 1229 LDMQREIVRFRRQDGEPFNLRIGINTGPVVAGVIGTRKFIYDLWGDAVNVASRMESQGEV 1288
Query 384 GQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
G+IQ+ LKD+F+ ERG I+VKG+G M T++L R+
Sbjct 1289 GRIQITAATKAILKDNFIFEERGVIDVKGRGKMVTFWLKDRR 1330
>gi|300865561|ref|ZP_07110340.1| PAS fold family [Oscillatoria sp. PCC 6506]
gi|300336433|emb|CBN55490.1| PAS fold family [Oscillatoria sp. PCC 6506]
Length=552
Score = 233 bits (594), Expect = 6e-59, Method: Compositional matrix adjust.
Identities = 109/219 (50%), Positives = 154/219 (71%), Gaps = 1/219 (0%)
Query 207 RAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASS 266
R +A + E ++E LL N+LP IA+RL++ E +IAD++DEA+VLFAD+V FT+ ++
Sbjct 335 RMQAALNIEQKKTEVLLLNILPKVIADRLRQ-EPVLIADRFDEATVLFADLVNFTQLSTR 393
Query 267 TAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDM 326
+LV L+ ++SAFD L +++ LEKIK GD+YMV G+P PR DH +A+A+ ALDM
Sbjct 394 KTATELVYLLNEMFSAFDRLTEEYNLEKIKTIGDAYMVAGGIPTPREDHAEAIAEMALDM 453
Query 327 TNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQI 386
Q RG +R+G+ +GPVVAGV+G+++F YD+WGDAVN ASRMES VG I
Sbjct 454 LEAINQFSAQRGEDFKIRIGINSGPVVAGVIGTKKFIYDLWGDAVNTASRMESHGIVGSI 513
Query 387 QVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
QV + YE L+D ++ ERG IN+KGKG M T+ L+G+K
Sbjct 514 QVSADTYELLRDKYLFEERGVINIKGKGEMITYLLMGKK 552
>gi|254415242|ref|ZP_05029004.1| hypothetical protein MC7420_2668 [Microcoleus chthonoplastes
PCC 7420]
gi|196178048|gb|EDX73050.1| hypothetical protein MC7420_2668 [Microcoleus chthonoplastes
PCC 7420]
Length=573
Score = 233 bits (593), Expect = 6e-59, Method: Compositional matrix adjust.
Identities = 111/212 (53%), Positives = 151/212 (72%), Gaps = 1/212 (0%)
Query 214 AEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPADLV 273
AE +++E LL N+LP SIA+RL++ + + IAD ++E +VLF+DIV FT + +P +LV
Sbjct 361 AEREKAENLLLNILPESIAKRLQK-DSDTIADSFEEVTVLFSDIVDFTRLSGEISPTELV 419
Query 274 RFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQL 333
L+ ++S FD LV+ HGLEKIK GDSYMVV G+P PR DH +A+A+FALDM +
Sbjct 420 NLLNEIFSRFDRLVELHGLEKIKTIGDSYMVVGGLPLPRQDHAEAVAEFALDMQQEIDAV 479
Query 334 KDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDEVY 393
+G+ +R+G+ +GPVVAGV+G ++F YD+WGD VN ASRMES G IQV D Y
Sbjct 480 NAQQGHAFMMRIGIHSGPVVAGVIGLKKFIYDLWGDTVNTASRMESHGLPGYIQVSDATY 539
Query 394 ERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
E LKD +V +ERG I+VKGKG M T++L RK
Sbjct 540 EHLKDKYVFQERGSISVKGKGEMTTYFLKERK 571
>gi|209522792|ref|ZP_03271350.1| adenylate/guanylate cyclase [Arthrospira maxima CS-328]
gi|209496841|gb|EDZ97138.1| adenylate/guanylate cyclase [Arthrospira maxima CS-328]
Length=1330
Score = 233 bits (593), Expect = 7e-59, Method: Composition-based stats.
Identities = 124/279 (45%), Positives = 175/279 (63%), Gaps = 12/279 (4%)
Query 158 GLVIALEF---LVPPDTGLQPP-----WAMSVSFVLTTVSACGVAVATVWFALRDTARAE 209
G I LE+ L PP+ G Q P A V + + +V + R+T
Sbjct 1053 GQTINLEYSMQLAPPEPGQQGPVNILPSAADADLVWFAATVSPMPDNSVIWVARNTTERR 1112
Query 210 AVMEA---EHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASS 266
V++A E +SE LL N+LP SIAERLK+ +I A+++++A+V+FAD+V FT ++
Sbjct 1113 RVLDALRVEQQKSERLLLNILPHSIAERLKQSPHSI-AERFEQATVMFADLVNFTGFSAQ 1171
Query 267 TAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDM 326
+P +LV L+ ++S FDEL +H LEKIK GDSYMVV G+P PR +H +A+A ALDM
Sbjct 1172 ISPTELVDLLNDIFSCFDELAQKHQLEKIKTIGDSYMVVGGLPTPRENHAEAIAQMALDM 1231
Query 327 TNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQI 386
+ + G P LR+G+ TGPVVAGV+G+R+F YD+WGDAVNVASRMES VG+I
Sbjct 1232 QREIVRFRRQDGEPFNLRIGMNTGPVVAGVIGTRKFIYDLWGDAVNVASRMESQGEVGRI 1291
Query 387 QVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
Q+ L D+F+ ERG I+VKG+G + T++L R+
Sbjct 1292 QITAATKALLNDNFIFEERGVIDVKGRGKLPTFWLKDRR 1330
>gi|254412323|ref|ZP_05026097.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
gi|196180633|gb|EDX75623.1| PAS fold family [Microcoleus chthonoplastes PCC 7420]
Length=667
Score = 232 bits (592), Expect = 8e-59, Method: Compositional matrix adjust.
Identities = 114/226 (51%), Positives = 156/226 (70%), Gaps = 8/226 (3%)
Query 207 RAEAVMEAEHDRSEALLANMLPASIAERLKEPERNI--------IADKYDEASVLFADIV 258
+AEA + AE ++SE LL N+LP +IA++LK+ + IA+++D+ ++LFADIV
Sbjct 441 QAEADLRAEQEKSERLLLNILPEAIAQQLKQNHSTLGKYHGEALIAEQFDDVTILFADIV 500
Query 259 GFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQA 318
GFT +S P +LV+ L + S FD L +++GLEKIK GD+YMV G+P PR DHT+A
Sbjct 501 GFTPLSSRMPPTELVQLLGTIISTFDLLSEEYGLEKIKTIGDAYMVACGLPLPRFDHTEA 560
Query 319 LADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRME 378
+AD AL+M V Q + G LR+G+ TGPV+AGV+G ++F YD+WGD VNVASRME
Sbjct 561 IADMALEMQRVITQFRMDTGEAFQLRIGINTGPVIAGVIGMKKFIYDLWGDTVNVASRME 620
Query 379 STDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGR 424
S + G IQV YERLKD +VL +RG I VKGKG M T++L G+
Sbjct 621 SQGTSGGIQVTQATYERLKDQYVLEKRGIIEVKGKGEMLTYWLTGK 666
>gi|338737510|ref|YP_004674472.1| Adenylate/guanylate cyclase [Hyphomicrobium sp. MC1]
gi|337758073|emb|CCB63896.1| Adenylate/guanylate cyclase [Hyphomicrobium sp. MC1]
Length=426
Score = 232 bits (592), Expect = 9e-59, Method: Compositional matrix adjust.
Identities = 141/403 (35%), Positives = 214/403 (54%), Gaps = 10/403 (2%)
Query 26 VRTQARAPTQHYAESVARRQRVLTITAWLAVVVTGSFALMQLATGAGGWYIAL-INVFTA 84
+R + + Y + RR +++ + + L VV T +A A+G A+ IN+ A
Sbjct 31 IRRISNIGIKGYPPDIQRRLKIVNVFSALVVVTTCIYAAQLWASGVKEMLPAVYINLGVA 90
Query 85 VTFAIVPLLHRFGGLVAPLTFIGTAYVAIFAIGWDVGTDAGAQFFFLVAAALVVLLVGIE 144
+ A+VPL+HR+ + L + + A+ G GA +++AAA ++
Sbjct 91 LIVALVPLMHRYNEIAGGLLLVVAEFSALIGFTAFFGRMGGAPLQYVIAAAAPFVIFEAR 150
Query 145 HTALAVGLAAVAAGLVIALEFLVPPDTGLQPPWAMSVS--FVLTTVSACGVAVATVWFAL 202
+ + + +A L + + F P + +++ +V V+ G+ A V++A
Sbjct 151 RFRIIIAIVWLALILHLFVWFSFPMEAAKFRADEKTINSLYVQAAVTTFGLIAACVYYAF 210
Query 203 RDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTE 262
RA+A +E +L N+LP S+ ERLKE IAD + EASVLFADI GF
Sbjct 211 SLFERAKA-------ETETVLRNVLPDSVVERLKEAPGETIADGFSEASVLFADITGFVG 263
Query 263 RASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADF 322
A P V L+ L AFDE+ D HG+EKIK GD+YMV SGVP PR DH +ALA
Sbjct 264 MARGLGPEKTVALLNHLVIAFDEIADHHGVEKIKTIGDAYMVASGVPVPRKDHVEALAAT 323
Query 323 ALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDS 382
ALD+ ++ P+ +RVG+A+GP++AG++G +F YDVWGD VN+ASR+E + +
Sbjct 324 ALDIVTAVKRISIEENIPISVRVGMASGPMMAGIIGKNKFSYDVWGDPVNLASRLEQSST 383
Query 383 VGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
G I + L+ FVL R I +KG G +WYL+ RK
Sbjct 384 PGFIAICPTCAGALQSTFVLEPRADIEIKGVGQQTSWYLLARK 426
>gi|254410382|ref|ZP_05024161.1| Adenylate and Guanylate cyclase catalytic domain protein [Microcoleus
chthonoplastes PCC 7420]
gi|196182588|gb|EDX77573.1| Adenylate and Guanylate cyclase catalytic domain protein [Microcoleus
chthonoplastes PCC 7420]
Length=472
Score = 231 bits (590), Expect = 1e-58, Method: Compositional matrix adjust.
Identities = 108/238 (46%), Positives = 156/238 (66%), Gaps = 1/238 (0%)
Query 188 VSACGVAVATVWFALRDTARAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKY 247
++A +++ + + R ++ E ++SE LL N+LP IA RLK+ + IAD +
Sbjct 232 MTAFNQMFQRIFWEIAERKRTAEILRVEQEKSERLLLNILPEPIAGRLKQ-NQTCIADGF 290
Query 248 DEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSG 307
E ++LFADIVGFT+ + +P +LV L+ ++SAFD L ++H LEKIK GD+YMV SG
Sbjct 291 TEVTILFADIVGFTQLSERISPTELVNLLNEIFSAFDHLTEKHNLEKIKTIGDAYMVASG 350
Query 308 VPRPRPDHTQALADFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVW 367
+P+P PDH A+A+ ALDM Q + +R+G+ TG VVAGV+G+++F YD+W
Sbjct 351 LPKPHPDHAAAIAEMALDMQQEIQQFNQKHHAELSIRIGINTGSVVAGVIGTKKFIYDLW 410
Query 368 GDAVNVASRMESTDSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
GDAVN ASRMES G IQV Y+ L+D++V +ERG I VKGKG M T++L +K
Sbjct 411 GDAVNTASRMESHGIPGTIQVTAATYQHLQDNYVFQERGIIPVKGKGEMMTYFLTAKK 468
>gi|254410580|ref|ZP_05024359.1| Adenylate and Guanylate cyclase catalytic domain protein [Microcoleus
chthonoplastes PCC 7420]
gi|196182786|gb|EDX77771.1| Adenylate and Guanylate cyclase catalytic domain protein [Microcoleus
chthonoplastes PCC 7420]
Length=586
Score = 231 bits (589), Expect = 2e-58, Method: Compositional matrix adjust.
Identities = 112/216 (52%), Positives = 150/216 (70%), Gaps = 1/216 (0%)
Query 210 AVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAP 269
A +EAE ++SE LL N+LP IA+RLK+ ++ I AD + EA+VLFADIVGFT+ + +
Sbjct 364 AEIEAEREKSELLLLNILPKPIADRLKQNQQTI-ADSFTEATVLFADIVGFTQLSQRISA 422
Query 270 ADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNV 329
+LV+ L+ ++SAFD+L + +GLEKIK GD+YMVV G+P P +H A+AD AL+M
Sbjct 423 TELVQLLNEIFSAFDQLTETYGLEKIKTIGDAYMVVGGLPTPCDNHADAIADMALEMQQQ 482
Query 330 AAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVP 389
AQ G P +R+G+ TGPVVAGV+G+++F YD+WGDAVN ASRMES G IQV
Sbjct 483 VAQFSAKYGEPFKIRIGINTGPVVAGVIGTKKFIYDLWGDAVNTASRMESHGVPGGIQVS 542
Query 390 DEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
Y+ L+D + ERG I VKGKG M T+ L RK
Sbjct 543 ASTYQHLRDKYQFEERGTIQVKGKGEMMTYLLKNRK 578
>gi|209528443|ref|ZP_03276873.1| adenylate/guanylate cyclase [Arthrospira maxima CS-328]
gi|209491122|gb|EDZ91547.1| adenylate/guanylate cyclase [Arthrospira maxima CS-328]
Length=352
Score = 230 bits (586), Expect = 4e-58, Method: Compositional matrix adjust.
Identities = 112/225 (50%), Positives = 159/225 (71%), Gaps = 2/225 (0%)
Query 202 LRDTARAE-AVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGF 260
LRD +A + AE +SE LL N+LPA IA+RLK+ E + IAD + + +VLFADIV F
Sbjct 128 LRDQEQAYLQKLAAEQQKSERLLLNILPAPIAQRLKQGE-STIADSFADVTVLFADIVNF 186
Query 261 TERASSTAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALA 320
T+ + + +PA+LV L++++SAFD+L + +GLEKIK GD+YMVV G+P PRPDH +A+A
Sbjct 187 TKLSDNLSPAELVEILNQIFSAFDQLAENYGLEKIKTIGDAYMVVGGLPTPRPDHAEAIA 246
Query 321 DFALDMTNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMEST 380
D AL+M + G + +R+G+ TGPV AGV+G+R+F YD+WGD VN A+RMES
Sbjct 247 DMALEMQKIVTNFSLKPGETLTMRMGINTGPVEAGVIGTRKFAYDLWGDTVNTANRMESH 306
Query 381 DSVGQIQVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
G+IQV + Y+RL+ + + RG I+VKGKG M T++LI +K
Sbjct 307 GLAGKIQVTETTYQRLRHGYEFQPRGIIDVKGKGEMNTYFLIMKK 351
>gi|300866944|ref|ZP_07111616.1| putative Adenylate cyclase [Oscillatoria sp. PCC 6506]
gi|300335048|emb|CBN56778.1| putative Adenylate cyclase [Oscillatoria sp. PCC 6506]
Length=663
Score = 230 bits (586), Expect = 4e-58, Method: Compositional matrix adjust.
Identities = 111/219 (51%), Positives = 154/219 (71%), Gaps = 1/219 (0%)
Query 207 RAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASS 266
R A + E +RSE LL N+LP+ IAERLK+ + A+ ++EA++LFADIVGFT +S
Sbjct 442 RRTAQLRKEKERSEQLLLNILPSEIAERLKKTNESP-AEHFEEATILFADIVGFTSLSSR 500
Query 267 TAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDM 326
P +LV L++++SAFD+L +++ LEKIK GD+YMVV G+P PR DH A+A+ ALDM
Sbjct 501 MEPMELVGGLNQIFSAFDQLTEKYNLEKIKTIGDAYMVVGGLPLPRSDHATAIANMALDM 560
Query 327 TNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQI 386
L G + +R+G+ +GPV+AGV+G ++F YD+WGDAVNVASRMES G I
Sbjct 561 QAYMQSLDSIFGESLEIRIGINSGPVIAGVIGIKKFIYDLWGDAVNVASRMESHGKPGYI 620
Query 387 QVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
QV + Y LKDD++L RG I VKG+G M T++L+GR+
Sbjct 621 QVTEATYAHLKDDYILESRGTIAVKGRGEMTTYWLVGRR 659
>gi|334120376|ref|ZP_08494457.1| adenylate/guanylate cyclase with GAF and PAS/PAC sensors [Microcoleus
vaginatus FGP-2]
gi|333456723|gb|EGK85353.1| adenylate/guanylate cyclase with GAF and PAS/PAC sensors [Microcoleus
vaginatus FGP-2]
Length=548
Score = 229 bits (585), Expect = 6e-58, Method: Compositional matrix adjust.
Identities = 108/223 (49%), Positives = 158/223 (71%), Gaps = 1/223 (0%)
Query 207 RAEAVMEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASS 266
+ EA + E + +E+LL N+LP +IA+RLK + +IADK+++A++LFAD+V FT+ +++
Sbjct 324 QMEAALRKEQNTTESLLLNILPEAIADRLKY-QPGVIADKFEKATILFADLVNFTQISTT 382
Query 267 TAPADLVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDM 326
+ LV L+ ++SAFDEL ++HGLEKIK GD+YMV G+P RPDH +A+A+ ALDM
Sbjct 383 MSATKLVYLLNEIFSAFDELSEKHGLEKIKTIGDAYMVAGGIPIERPDHAEAIAEMALDM 442
Query 327 TNVAAQLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQI 386
+L LR+G+ +GPVVAGV+G+++F YD+WG+AVN ASRMES G+I
Sbjct 443 LAAIQELNVKLDAKFDLRIGINSGPVVAGVIGTKKFIYDLWGNAVNTASRMESHGITGRI 502
Query 387 QVPDEVYERLKDDFVLRERGHINVKGKGVMRTWYLIGRKVAAD 429
QV Y+ L+D + +RG I +KGKG MRT+ L GRK+A+D
Sbjct 503 QVSHYTYKLLQDKYEFEDRGEIEIKGKGEMRTYLLTGRKIASD 545
>gi|119487593|ref|ZP_01621203.1| adenylate cyclase [Lyngbya sp. PCC 8106]
gi|119455762|gb|EAW36898.1| adenylate cyclase [Lyngbya sp. PCC 8106]
Length=442
Score = 229 bits (585), Expect = 6e-58, Method: Compositional matrix adjust.
Identities = 109/214 (51%), Positives = 145/214 (68%), Gaps = 0/214 (0%)
Query 212 MEAEHDRSEALLANMLPASIAERLKEPERNIIADKYDEASVLFADIVGFTERASSTAPAD 271
++ E +RSEAL+ N+LP IA+RLK+ IAD + +A VLF DIVGFTE + PA+
Sbjct 228 LQVEQERSEALILNILPVPIAQRLKQKPVTTIADNFTDAGVLFGDIVGFTELSGKMPPAE 287
Query 272 LVRFLDRLYSAFDELVDQHGLEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAA 331
LV+ L +++S FD L D+H LEKIK GD+YMVVSG+P P+ D+ + +AD ALDM
Sbjct 288 LVQLLGQIFSRFDHLADKHNLEKIKTIGDAYMVVSGLPIPKEDYAERIADMALDMQKTIL 347
Query 332 QLKDPRGNPVPLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDE 391
+ +R+G+A GPVVAGV+G R+F YD+WGD VN+ASRMES +IQV +
Sbjct 348 EFNAETERKFQMRIGIAIGPVVAGVIGLRKFIYDLWGDTVNIASRMESHGIANEIQVTET 407
Query 392 VYERLKDDFVLRERGHINVKGKGVMRTWYLIGRK 425
Y LKDD+ L +RG I VKGKG M T+ L G+K
Sbjct 408 TYHALKDDYSLEKRGTILVKGKGEMTTYLLKGKK 441
Lambda K H
0.322 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 912611074200
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
Posted date: Sep 5, 2011 4:36 AM
Number of letters in database: 5,219,829,388
Number of sequences in database: 15,229,318
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40