BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1661 Length=2126 Score E Sequences producing significant alignments: (Bits) Value gi|15608799|ref|NP_216177.1| polyketide synthase pks7 [Mycobacte... 4156 0.0 gi|306788762|ref|ZP_07427084.1| polyketide synthase pks7 [Mycoba... 4153 0.0 gi|289745901|ref|ZP_06505279.1| polyketide synthase pks7 [Mycoba... 4153 0.0 gi|254231859|ref|ZP_04925186.1| polyketide synthase pks7 [Mycoba... 4153 0.0 gi|289574330|ref|ZP_06454557.1| polyketide synthase pks7 [Mycoba... 4149 0.0 gi|298525160|ref|ZP_07012569.1| polyketide synthase pks7 [Mycoba... 4147 0.0 gi|31792848|ref|NP_855341.1| polyketide synthase pks7 [Mycobacte... 4146 0.0 gi|340626667|ref|YP_004745119.1| putative polyketide synthase PK... 4141 0.0 gi|344219482|gb|AEN00113.1| polyketide synthase pks7 [Mycobacter... 3716 0.0 gi|308401191|ref|ZP_07493357.2| putative acyl transferase domain... 3591 0.0 gi|289447274|ref|ZP_06437018.1| polyketide synthase pks7 [Mycoba... 3456 0.0 gi|118463404|ref|YP_882293.1| RifB protein [Mycobacterium avium ... 2874 0.0 gi|254775560|ref|ZP_05217076.1| RifB protein [Mycobacterium aviu... 2873 0.0 gi|342860755|ref|ZP_08717405.1| RifB protein [Mycobacterium colo... 2816 0.0 gi|183982485|ref|YP_001850776.1| polyketide synthase Pks7 [Mycob... 2796 0.0 gi|289753750|ref|ZP_06513128.1| polyketide synthase [Mycobacteri... 2795 0.0 gi|41407468|ref|NP_960304.1| Pks7 [Mycobacterium avium subsp. pa... 2617 0.0 gi|254550669|ref|ZP_05141116.1| polyketide synthase pks7 [Mycoba... 2551 0.0 gi|336457822|gb|EGO36816.1| polyketide synthase family protein [... 2541 0.0 gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules ... 2382 0.0 gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Myco... 2376 0.0 gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 ... 2360 0.0 gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules ... 2348 0.0 gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 [Mycob... 2328 0.0 gi|308380139|ref|ZP_07669124.1| putative acyl transferase domain... 2324 0.0 gi|308376783|ref|ZP_07668349.1| putative acyl transferase domain... 2321 0.0 gi|183980137|ref|YP_001848428.1| polyketide synthase PKS [Mycoba... 2319 0.0 gi|183983097|ref|YP_001851388.1| polyketide synthase PKS [Mycoba... 2265 0.0 gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Myc... 2259 0.0 gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycoba... 2255 0.0 gi|296164561|ref|ZP_06847131.1| erythronolide synthase, modules ... 2241 0.0 gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085... 2212 0.0 gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12... 2209 0.0 gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_1100... 2208 0.0 gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobact... 2208 0.0 gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_1090... 2208 0.0 gi|41407894|ref|NP_960730.1| Pks12 [Mycobacterium avium subsp. p... 2206 0.0 gi|118463709|ref|YP_881643.1| erythronolide synthase, modules 3 ... 2206 0.0 gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacteri... 2201 0.0 gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycob... 2199 0.0 gi|289762206|ref|ZP_06521584.1| predicted protein [Mycobacterium... 2196 0.0 gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933... 2194 0.0 gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 ... 2194 0.0 gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycob... 2193 0.0 gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium ... 2193 0.0 gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobact... 2193 0.0 gi|342859764|ref|ZP_08716417.1| erythronolide synthase, modules ... 2191 0.0 gi|254822171|ref|ZP_05227172.1| erythronolide synthase, modules ... 2190 0.0 gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Myco... 2190 0.0 gi|340627059|ref|YP_004745511.1| putative polyketide synthase pk... 2181 0.0 >gi|15608799|ref|NP_216177.1| polyketide synthase pks7 [Mycobacterium tuberculosis H37Rv] gi|15841117|ref|NP_336154.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|148661457|ref|YP_001282980.1| putative polyketide synthase Pks7 [Mycobacterium tuberculosis H37Ra] 27 more sequence titles Length=2126 Score = 4156 bits (10778), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2126/2126 (100%), Positives = 2126/2126 (100%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|306788762|ref|ZP_07427084.1| polyketide synthase pks7 [Mycobacterium tuberculosis SUMu004] gi|306793096|ref|ZP_07431398.1| polyketide synthase pks7 [Mycobacterium tuberculosis SUMu005] gi|308334681|gb|EFP23532.1| polyketide synthase pks7 [Mycobacterium tuberculosis SUMu004] gi|308338474|gb|EFP27325.1| polyketide synthase pks7 [Mycobacterium tuberculosis SUMu005] Length=2126 Score = 4153 bits (10772), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2125/2126 (99%), Positives = 2125/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLG DDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGSDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|289745901|ref|ZP_06505279.1| polyketide synthase pks7 [Mycobacterium tuberculosis 02_1987] gi|294996612|ref|ZP_06802303.1| polyketide synthase pks7 [Mycobacterium tuberculosis 210] gi|289686429|gb|EFD53917.1| polyketide synthase pks7 [Mycobacterium tuberculosis 02_1987] gi|326903275|gb|EGE50208.1| polyketide synthase pks7 [Mycobacterium tuberculosis W-148] gi|339294619|gb|AEJ46730.1| polyketide synthase pks7 [Mycobacterium tuberculosis CCDC5079] gi|339298252|gb|AEJ50362.1| polyketide synthase pks7 [Mycobacterium tuberculosis CCDC5180] Length=2126 Score = 4153 bits (10771), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2125/2126 (99%), Positives = 2125/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQF RAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFARAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|254231859|ref|ZP_04925186.1| polyketide synthase pks7 [Mycobacterium tuberculosis C] gi|124600918|gb|EAY59928.1| polyketide synthase pks7 [Mycobacterium tuberculosis C] Length=2126 Score = 4153 bits (10770), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2125/2126 (99%), Positives = 2125/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVS ARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSLARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|289574330|ref|ZP_06454557.1| polyketide synthase pks7 [Mycobacterium tuberculosis K85] gi|289538761|gb|EFD43339.1| polyketide synthase pks7 [Mycobacterium tuberculosis K85] Length=2126 Score = 4149 bits (10760), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2125/2126 (99%), Positives = 2125/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSL DAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLWDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|298525160|ref|ZP_07012569.1| polyketide synthase pks7 [Mycobacterium tuberculosis 94_M4241A] gi|298494954|gb|EFI30248.1| polyketide synthase pks7 [Mycobacterium tuberculosis 94_M4241A] Length=2126 Score = 4147 bits (10755), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2123/2126 (99%), Positives = 2123/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQF RAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFARAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVV FPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVPFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVAL MYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALVMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|31792848|ref|NP_855341.1| polyketide synthase pks7 [Mycobacterium bovis AF2122/97] gi|121637569|ref|YP_977792.1| putative polyketide synthase pks7 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990044|ref|YP_002644731.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|31618438|emb|CAD96356.1| Probable polyketide synthase pks7 [Mycobacterium bovis AF2122/97] gi|121493216|emb|CAL71687.1| Probable polyketide synthase pks7 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224773157|dbj|BAH25963.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601587|emb|CCC64260.1| probable polyketide synthase pks7 [Mycobacterium bovis BCG str. Moreau RDJ] Length=2126 Score = 4146 bits (10752), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2124/2126 (99%), Positives = 2124/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSL DAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLWDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAV VELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVPVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|340626667|ref|YP_004745119.1| putative polyketide synthase PKS7 [Mycobacterium canettii CIPT 140010059] gi|340004857|emb|CCC44002.1| putative polyketide synthase PKS7 [Mycobacterium canettii CIPT 140010059] Length=2126 Score = 4141 bits (10740), Expect = 0.0, Method: Compositional matrix adjust. Identities = 2120/2126 (99%), Positives = 2122/2126 (99%), Gaps = 0/2126 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILE+APAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEQAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTY FARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYGFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPA GVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAGGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSW+GVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWEGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASD TGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDVTGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLP GGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPRGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAA 1920 Query 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD Sbjct 1921 RLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTD 1980 Query 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP Sbjct 1981 LVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTP 2040 Query 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS Sbjct 2041 ATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS 2100 Query 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 LTTEDDDIAAATESQLFAILDEELGS Sbjct 2101 LTTEDDDIAAATESQLFAILDEELGS 2126 >gi|344219482|gb|AEN00113.1| polyketide synthase pks7 [Mycobacterium tuberculosis CTRI-2] Length=2056 Score = 3716 bits (9636), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1904/1904 (100%), Positives = 1904/1904 (100%), Gaps = 0/1904 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVT 1440 Query 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA Sbjct 1441 GLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAA 1500 Query 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE Sbjct 1501 GQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEE 1560 Query 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR Sbjct 1561 AFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYR 1620 Query 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT Sbjct 1621 AFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT 1680 Query 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA Sbjct 1681 IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAA 1740 Query 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT Sbjct 1741 LLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDT 1800 Query 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG Sbjct 1801 VLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRG 1860 Query 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALG 1904 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALG Sbjct 1861 LAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALG 1904 >gi|308401191|ref|ZP_07493357.2| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu012] gi|308366102|gb|EFP54953.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu012] Length=1846 Score = 3591 bits (9313), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1845/1846 (99%), Positives = 1846/1846 (100%), Gaps = 0/1846 (0%) Query 281 LADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG 340 +ADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG Sbjct 1 MADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG 60 Query 341 HGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHG 400 HGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHG Sbjct 61 HGTGTTLGDPIEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHG 120 Query 401 VLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAP 460 VLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAP Sbjct 121 VLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAP 180 Query 461 AVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSL 520 AVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSL Sbjct 181 AVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSL 240 Query 521 FDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQL 580 FDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQL Sbjct 241 FDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQL 300 Query 581 CATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELW 640 CATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELW Sbjct 301 CATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELW 360 Query 641 RSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQP 700 RSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQP Sbjct 361 RSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQP 420 Query 701 QAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQ 760 QAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQ Sbjct 421 QAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQ 480 Query 761 VDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNA 820 VDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNA Sbjct 481 VDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNA 540 Query 821 FDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAH 880 FDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAH Sbjct 541 FDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAH 600 Query 881 VAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAV 940 VAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAV Sbjct 601 VAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAV 660 Query 941 VQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTL 1000 VQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTL Sbjct 661 VQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTL 720 Query 1001 QAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAA 1060 QAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAA Sbjct 721 QAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAA 780 Query 1061 ELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRG 1120 ELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRG Sbjct 781 ELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRG 840 Query 1121 FGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELA 1180 FGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELA Sbjct 841 FGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELA 900 Query 1181 DPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPH 1240 DPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPH Sbjct 901 DPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPH 960 Query 1241 AGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVW 1300 AGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVW Sbjct 961 AGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVW 1020 Query 1301 GLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLT 1360 GLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLT Sbjct 1021 GLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLT 1080 Query 1361 LPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPG 1420 LPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPG Sbjct 1081 LPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPG 1140 Query 1421 GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAA 1480 GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAA Sbjct 1141 GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAA 1200 Query 1481 VPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTL 1540 VPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTL Sbjct 1201 VPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTL 1260 Query 1541 RAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELG 1600 RAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELG Sbjct 1261 RAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELG 1320 Query 1601 KTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARC 1660 KTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARC Sbjct 1321 KTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARC 1380 Query 1661 APAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVA 1720 APAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVA Sbjct 1381 APAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVA 1440 Query 1721 NLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFH 1780 NLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFH Sbjct 1441 NLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFH 1500 Query 1781 AAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQG 1840 AAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQG Sbjct 1501 AAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQG 1560 Query 1841 NYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTE 1900 NYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTE Sbjct 1561 NYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTE 1620 Query 1901 QALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMS 1960 QALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMS Sbjct 1621 QALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMS 1680 Query 1961 GLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNR 2020 GLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNR Sbjct 1681 GLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNR 1740 Query 2021 LKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQP 2080 LKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQP Sbjct 1741 LKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQP 1800 Query 2081 DLSANVKAHLRTRLQTMLTSLTTEDDDIAAATESQLFAILDEELGS 2126 DLSANVKAHLRTRLQTMLTSLTTEDDDIAAATESQLFAILDEELGS Sbjct 1801 DLSANVKAHLRTRLQTMLTSLTTEDDDIAAATESQLFAILDEELGS 1846 >gi|289447274|ref|ZP_06437018.1| polyketide synthase pks7 [Mycobacterium tuberculosis CPHL_A] gi|289420232|gb|EFD17433.1| polyketide synthase pks7 [Mycobacterium tuberculosis CPHL_A] Length=1814 Score = 3456 bits (8962), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1784/1813 (99%), Positives = 1786/1813 (99%), Gaps = 0/1813 (0%) Query 314 GPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRPLWLGS 373 G RVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR + G Sbjct 2 GRRSNRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRAGRSAVVAGG 61 Query 374 IKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHV 433 + VIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHV Sbjct 62 RSNRTSVIRRRLRGRRVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHV 121 Query 434 PGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQAR 493 PGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQAR Sbjct 122 PGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQAR 181 Query 494 RLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVA 553 RLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVA Sbjct 182 RLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVA 241 Query 554 GRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGA 613 GRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGA Sbjct 242 GRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGA 301 Query 614 PGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAA 673 PGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAA Sbjct 302 PGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAA 361 Query 674 AVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAV 733 AVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAV Sbjct 362 AVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAV 421 Query 734 TELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELM 793 TELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELM Sbjct 422 TELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELM 481 Query 794 DTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGAT 853 DTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGAT Sbjct 482 DTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGAT 541 Query 854 GEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFW 913 GEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFW Sbjct 542 GEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFW 601 Query 914 LDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVL 973 LDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVL Sbjct 602 LDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVL 661 Query 974 FPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSA 1033 FPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSA Sbjct 662 FPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSA 721 Query 1034 AGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAF 1093 AGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAF Sbjct 722 AGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAF 781 Query 1094 RGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGV 1153 RGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGV Sbjct 782 RGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGV 841 Query 1154 CLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGL 1213 CLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGL Sbjct 842 CLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRSTAGDRGL 901 Query 1214 LEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDAT 1273 LEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDAT Sbjct 902 LEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDAT 961 Query 1274 GLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGA 1333 GLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGA Sbjct 962 GLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGA 1021 Query 1334 RSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELA 1393 RSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELA Sbjct 1022 RSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELA 1081 Query 1394 TGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLG 1453 TGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLG Sbjct 1082 TGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLG 1141 Query 1454 LVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGV 1513 LVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGV Sbjct 1142 LVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGV 1201 Query 1514 GMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDV 1573 GMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDV Sbjct 1202 GMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDV 1261 Query 1574 VLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIA 1633 VLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIA Sbjct 1262 VLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIA 1321 Query 1634 AMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAG 1693 AMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAG Sbjct 1322 AMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAG 1381 Query 1694 GTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVS 1753 GTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVS Sbjct 1382 GTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVS 1441 Query 1754 CDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLH 1813 CDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLH Sbjct 1442 CDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLH 1501 Query 1814 ELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQ 1873 ELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQ Sbjct 1502 ELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQ 1561 Query 1874 ASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAA 1933 ASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAA Sbjct 1562 ASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAA 1621 Query 1934 LPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRS 1993 LPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRS Sbjct 1622 LPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRS 1681 Query 1994 SSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVT 2053 SSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVT Sbjct 1682 SSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVT 1741 Query 2054 ASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAAATE 2113 ASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAAATE Sbjct 1742 ASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTEDDDIAAATE 1801 Query 2114 SQLFAILDEELGS 2126 SQLFAILDEELGS Sbjct 1802 SQLFAILDEELGS 1814 >gi|118463404|ref|YP_882293.1| RifB protein [Mycobacterium avium 104] gi|48928158|gb|AAT47757.1| possible polyketide synthase [Mycobacterium avium] gi|118164691|gb|ABK65588.1| RifB protein [Mycobacterium avium 104] Length=2124 Score = 2874 bits (7451), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1529/2143 (72%), Positives = 1720/2143 (81%), Gaps = 38/2143 (1%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 M+ E+LV+ALR+SLK+NERLKRENR L TEPVAVVGMGCRYPGGVDSPE LWE+V Sbjct 1 MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMGCRYPGGVDSPEALWEMV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 GRD VSEFPADRGWD+AGLFD DPDAVGKSY RCGGFLT V FDA FFGIAPSEALA Sbjct 61 VEGRDVVSEFPADRGWDLAGLFDADPDAVGKSYCRCGGFLTGVGDFDAAFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDP TLRGS TGVFAG+FHGSYGGQGRVPG+LERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPATLRGSATGVFAGIFHGSYGGQGRVPGNLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAY LGL+GPAVSVDTACSSSLVALHLA QSLR GECDLAL GGVTVMATPA Sbjct 181 TLSVASGRVAYALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRAL+ADGRCKAYAGAADGT F+EG GVLVL RL+DARRLGH VLA++RGSAV Sbjct 241 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHSVLAVLRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGP+QQRVI AALA+ARLG ADVD+VEGHGTGT LGDPIEAQA+LATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEGHGTGTMLGDPIEAQALLATY 360 Query 361 GQ-RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSA 419 GQ RP D PLWLGSIKSN+GHTSAAAG GVIKMVQA+RHGV+PKTLHVD PTP VDWSA Sbjct 361 GQDRPVDEPLWLGSIKSNMGHTSAAAGAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSA 420 Query 420 GAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWV 479 GAVSLLTE RPW RPRRAGVSSFGISGTNAHVI+E+ EP A V VPWV Sbjct 421 GAVSLLTEARPWPARDRPRRAGVSSFGISGTNAHVIVEQ---YEPETVAPQGGDVVVPWV 477 Query 480 LSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGL 539 LSARSA+ALTNQA RLLA V AD VR LDVGWSLV+TRS F+HRAV+VGAD QL+ L Sbjct 478 LSARSAEALTNQAARLLARVKADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLLRRL 537 Query 540 TGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALR 599 LA G PGA VV GRAQ VGKT FVFPGQG+QW GMGAQL + VFAEH+HRC RAL Sbjct 538 ADLAGGQPGAGVVTGRAQPVGKTVFVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCARALA 597 Query 600 EHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA 659 EHV+WSL+DV+RGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA Sbjct 598 EHVDWSLIDVIRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA 657 Query 660 AAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVN 719 AA VAGALSL DAA VVALRSRLLVRL G GGMVSLACG+ +AE+L + WG+RLNIA VN Sbjct 658 AACVAGALSLHDAARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGERLNIATVN 717 Query 720 GVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRT 779 G+S+VV++GE DA+TEL+ RC A+ IRARRIDVDYASHS QV+ IR+ L ALRGI PR+ Sbjct 718 GISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAEALRGIAPRS 777 Query 780 STVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIA 839 S VAFFSTVTGELMDTA ++ +YW+RSIRQ VQFERAVR A + GYR F+E SPHPVL A Sbjct 778 SAVAFFSTVTGELMDTAALDGDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPVLTA 837 Query 840 GIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRR 899 IEET+ D G+ VIP+LGRDDGG RFWLSAGQA V+GV VDW A LGGRR Sbjct 838 AIEETMPD-----GGQGCVIPSLGRDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRR 892 Query 900 VELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVA 959 V+LPTY F RQ FWL G D+ +GL GAEHGLL AV+ RPDSGGVVLTGR+S A Sbjct 893 VDLPTYGFVRQHFWLPGGSTGSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSA 952 Query 960 APWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAD-GVRVQVVVG 1018 WLADHAVG VLFPG GFVELA+RAGDEVGC V+ ELTL APL LPA GVR+Q+VVG Sbjct 953 QAWLADHAVGDTVLFPGAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVG 1012 Query 1019 GVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADG 1078 +++G R + VYSAA DS W LHA+GVL G+V PA +LS+WPP+GA A+DV G Sbjct 1013 APDEAGRRPLSVYSAAAHQDSE--WMLHAEGVLRTGTVTPAGDLSIWPPIGATAVDVTGG 1070 Query 1079 YQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPI-RGFGIHPAVLDAALHAWGI 1137 Y LA RGY YG AFRGL+A+W+RG E+FA+V LP+ FG+HP +LDAALHA G+ Sbjct 1071 YARLAQRGYEYGRAFRGLRAMWQRGDEIFAEVALPDDAAAGDDFGVHPVLLDAALHALGV 1130 Query 1138 VEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRP 1197 + QT+LPFSWQGV LHASGA+R RVR+AP G GAVSVELAD GLPVLSVR + +RP Sbjct 1131 AGEKDQTVLPFSWQGVALHASGASRARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRP 1190 Query 1198 VSAAALSRS--TAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYR 1255 VS LS + TA GLL++IW+P+ L G D+GD+ +WE H GGDV+ +V+ Sbjct 1191 VSPGQLSAAMGTAQPSGLLDVIWSPIALGGNDLGDEVTLWEPGEH-----GGDVVKSVHA 1245 Query 1256 GVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVV 1315 V E L VLQSWL + G+ V T GAV +DV+DLAGAAVWGLVRSAQAEHPGR+V Sbjct 1246 AVTETLAVLQSWLDGEGAGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLV 1305 Query 1316 LVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGG 1375 L+D+DGS+ + GEPQ+VVR+G +AARL P AG TL S G WRL AGG Sbjct 1306 LIDSDGSLDARAVI----PCGEPQVVVRQGVAHAARLRPARAGATLGLPS-GAWRLDAGG 1360 Query 1376 GGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEV 1435 GTL D+VV+ ELA GQVRVAV AVGVNFRDVLVALGMYPGGG LG +GAGVVVEV Sbjct 1361 EGTLGDLVVSRCPRTELADGQVRVAVAAVGVNFRDVLVALGMYPGGGRLGAEGAGVVVEV 1420 Query 1436 GPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVL 1495 GP VTGLAVGD VMGLLG+VGSEAVVD RL+T VP G SLV AA VPV FLTA YGLSVL Sbjct 1421 GPAVTGLAVGDPVMGLLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVL 1480 Query 1496 AEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRS 1555 + + G++VLVH TGGVGMAAV LAR++GAEVF TASR KWDTLRAMGFDD HI DSRS Sbjct 1481 SGLRPGERVLVHTATGGVGMAAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRS 1540 Query 1556 LEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHR 1615 +FE+ FL AT G+GVDVVLNSLAGEFTDASLRLL GGRFIE+GKTD+RD VA+R+R Sbjct 1541 PDFEQKFLAATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPDVVAQRYR 1600 Query 1616 GVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIG 1675 G RYRAFDL+EAGPDR AAML+E+VGLL AGVL LP+KTFD RCA AYR+VSQARHIG Sbjct 1601 GARYRAFDLMEAGPDRTAAMLAEIVGLLRAGVLTPLPLKTFDVRCASTAYRYVSQARHIG 1660 Query 1676 KVVLTIPDGP-----GGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGE 1730 KVVLT+P GP G GLA TV++TGGTGMAGSA+A HLV R+ V ++VLVSR+G Sbjct 1661 KVVLTVPSGPGEVLSGCGGGLAQSTVLITGGTGMAGSALARHLVDRYRVGHVVLVSRTGA 1720 Query 1731 QADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVI 1790 QA AAE+ L+ GA +V++CDV DRDA+A +LAGL YPL+G+ HAAG+LDD ++ Sbjct 1721 QAAGAAELVDELQRAGASASVLACDVGDRDAVATMLAGLPSGYPLRGIVHAAGILDDGLL 1780 Query 1791 TGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLD 1850 + LTPDRVD VLRAKVDGAWNLHELT+D+DLSAFVVFSSMAGIVGTP Q NYAAAN+FLD Sbjct 1781 SSLTPDRVDAVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGTPGQANYAAANSFLD 1840 Query 1851 GLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTAL 1910 GLVA+RR+ GLAGLS+AWGLWEQASAMT HLG+RD+ARM++ GLAPL+TEQAL D A+ Sbjct 1841 GLVAHRRADGLAGLSLAWGLWEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAAM 1900 Query 1911 QADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALT 1970 + V+VAARLDRAAL+ AALP L +LAAGPTRR ID AD SMSGL +RLH L+ Sbjct 1901 LVETPVLVAARLDRAALSENIAALPPLLRELAAGPTRRVIDDADVTASMSGLAARLHGLS 1960 Query 1971 PERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLS 2030 PE R+REL DLV NAA VLG DINA +AFQDLGFDSLTAVELRNRLK ATGLTLS Sbjct 1961 PEARRRELVDLVCGNAAMVLGVPDPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLS 2020 Query 2031 PTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHL 2090 PTLIFDYPTP LAEHLDSRL + G DQ L R +DITREL LL P +++ KA L Sbjct 2021 PTLIFDYPTPVVLAEHLDSRLAGSGGDDQPDLMGRFNDITRELQALLGAPHWNSDDKAVL 2080 Query 2091 RTRLQTMLTSLTTE--------DDDIAAATESQLFAILDEELG 2125 R R+ +L +L D+D+ AATESQLFAILDEELG Sbjct 2081 RARIHGLLGALPAGDGPDSAPLDEDLEAATESQLFAILDEELG 2123 >gi|254775560|ref|ZP_05217076.1| RifB protein [Mycobacterium avium subsp. avium ATCC 25291] Length=2124 Score = 2873 bits (7447), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1528/2143 (72%), Positives = 1721/2143 (81%), Gaps = 38/2143 (1%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 M+ E+LV+ALR+SLK+NERLKRENR L TEPVAVVGMGCRYPGGVDSPE LWE+V Sbjct 1 MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMGCRYPGGVDSPEALWEMV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 GRD VSEFPADRGWD+AGLFD DPDAVGKSY RCGGFLT V FDA FFGIAPSEALA Sbjct 61 VEGRDVVSEFPADRGWDLAGLFDADPDAVGKSYCRCGGFLTGVGDFDAAFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEV WEALERAGIDP TLRGS TGVFAG+FHGSYGGQGRVPG+LERYGLRGS Sbjct 121 MDPQQRLLLEVCWEALERAGIDPATLRGSATGVFAGIFHGSYGGQGRVPGNLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAY LGL+GPAVSVDTACSSSLVALHLA QSLR GECDLAL GGVTVMATPA Sbjct 181 TLSVASGRVAYALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRAL+ADGRCKAYAGAADGT F+EG GVLVL RL+DARRLGH VLA++RGSAV Sbjct 241 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHSVLAVLRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGP+QQRVI AALA+ARLG ADVD+VEGHGTGT LGDPIEAQA+LATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEGHGTGTMLGDPIEAQALLATY 360 Query 361 GQ-RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSA 419 GQ RP D PLWLGSIKSN+GHTSAAAG GVIKMVQA+RHGV+PKTLHVD PTP VDWSA Sbjct 361 GQDRPVDEPLWLGSIKSNMGHTSAAAGAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSA 420 Query 420 GAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWV 479 GAVSLLTE RPW RPRRAGVSSFGISGTNAHVI+E+ EP A V VPWV Sbjct 421 GAVSLLTEARPWPARDRPRRAGVSSFGISGTNAHVIVEQ---YEPETVAPQGGDVVVPWV 477 Query 480 LSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGL 539 LSARSA+ALTNQA RLLA V AD VR LDVGWSLV+TRS F+HRAV+VGAD QL+ L Sbjct 478 LSARSAEALTNQAARLLARVKADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLLRRL 537 Query 540 TGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALR 599 LA G PGA VV GRAQ VGKT FVFPGQG+QW GMGAQL + VFAEH+HRC RAL Sbjct 538 ADLAGGQPGAGVVTGRAQPVGKTVFVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCARALA 597 Query 600 EHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA 659 EHV+WSL+DV+RGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA Sbjct 598 EHVDWSLIDVIRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA 657 Query 660 AAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVN 719 AA VAGALSL+DAA VVALRSRLLVRL G GGMVSLACG+ +AE+L + WG+RLNIA VN Sbjct 658 AACVAGALSLQDAARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGERLNIATVN 717 Query 720 GVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRT 779 G+S+VV++GE DA+TEL+ RC A+ IRARRIDVDYASHS QV+ IR+ L ALRGI PR+ Sbjct 718 GISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAEALRGIAPRS 777 Query 780 STVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIA 839 S VAFFSTVTGELMDTA ++ +YW+RSIRQ VQFERAVR A + GYR F+E SPHPVL A Sbjct 778 SAVAFFSTVTGELMDTAALDGDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPVLTA 837 Query 840 GIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRR 899 IEET+ D G+ VIP+LGRDDG RFWLSAGQA V+GV VDW A LGGRR Sbjct 838 AIEETMPD-----GGQGCVIPSLGRDDGAPDRFWLSAGQAFVSGVVVDWCATLDGLGGRR 892 Query 900 VELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVA 959 V+LPTY F RQ FWL G D+ +GL GAEHGLL AV+ RPDSGGVVLTGR+S A Sbjct 893 VDLPTYGFVRQHFWLPGGSTGSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSA 952 Query 960 APWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAD-GVRVQVVVG 1018 WLADHAVG VLFPG GFVELA+RAGDEVGC V+ ELTL APL LPA GVR+Q+VVG Sbjct 953 QAWLADHAVGDTVLFPGAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVG 1012 Query 1019 GVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADG 1078 +++G R + VYSAA DS W LHA+GVL G+V PA +LS+WPP+GA A+DV G Sbjct 1013 APDEAGRRPLSVYSAAAHQDSE--WMLHAEGVLRAGTVTPAGDLSIWPPIGATAVDVTGG 1070 Query 1079 YQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPI-RGFGIHPAVLDAALHAWGI 1137 Y LA RGY YG AFRGL+A+W+RG E+FA+V+LP+ FG+HP +LDAALHA G+ Sbjct 1071 YARLAQRGYEYGRAFRGLRAMWQRGDEIFAEVSLPDDAAAGDDFGVHPVLLDAALHALGV 1130 Query 1138 VEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRP 1197 + QT+LPF+WQGV LHASGAAR RVR+AP G GAVSVELAD GLPVLSVR + +RP Sbjct 1131 AGEKDQTVLPFAWQGVALHASGAARARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRP 1190 Query 1198 VSAAALSRS--TAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYR 1255 VS LS + TA GLL++IW+P+ L G D+GD+ +WE H GGDV+ +V+ Sbjct 1191 VSPGQLSAAMGTAQPSGLLDVIWSPIALGGNDLGDEVTLWEPGEH-----GGDVVKSVHA 1245 Query 1256 GVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVV 1315 V E L VLQSWL + G+ V T GAV +DV+DLAGAAVWGLVRSAQAEHPGR+V Sbjct 1246 AVTETLAVLQSWLDGEGAGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLV 1305 Query 1316 LVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGG 1375 L+D+DGS+ + GEPQ+VVR+G +AARL P AG TL S G WRL AGG Sbjct 1306 LIDSDGSLDARAVI----PCGEPQVVVRQGVAHAARLRPARAGATLGLPS-GAWRLDAGG 1360 Query 1376 GGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEV 1435 GTL D+VV+ ELA GQVRVAV AVGVNFRDVLVALGMYPGGG LG +GAGVVVEV Sbjct 1361 EGTLGDLVVSRCPRTELADGQVRVAVAAVGVNFRDVLVALGMYPGGGRLGAEGAGVVVEV 1420 Query 1436 GPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVL 1495 GP VTGLAVGD VMGLLG+VGSEAVVD RL+T VP G SLV AA VPV FLTA YGLSVL Sbjct 1421 GPAVTGLAVGDPVMGLLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVL 1480 Query 1496 AEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRS 1555 A + G++VLVH TGGVGMAAV LAR++GAEVF TASR KWDTLRAMGFDD HI DSRS Sbjct 1481 AGLRPGERVLVHTATGGVGMAAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRS 1540 Query 1556 LEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHR 1615 +FE+ FL AT G+GVDVVLNSLAGEFTDASLRLL GGRFIE+GKTD+RD VA+R+R Sbjct 1541 PDFEQKFLAATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPDVVAQRYR 1600 Query 1616 GVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIG 1675 G RYRAFDL+EA PDR AAML+E+VGLL AGVL LP+KTFD RCA AAYR+VSQARHIG Sbjct 1601 GARYRAFDLMEACPDRTAAMLAEIVGLLRAGVLTPLPLKTFDVRCASAAYRYVSQARHIG 1660 Query 1676 KVVLTIPDGP-----GGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGE 1730 KVVLT+P GP G GLA TV++TGGTGMAGSA+A HLV R+ V ++ LVSR+G Sbjct 1661 KVVLTVPSGPGEVLSGCGGGLAQSTVLITGGTGMAGSALARHLVDRYRVGHVALVSRTGA 1720 Query 1731 QADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVI 1790 QA AAE+ L+ GA +V++CDVADRDA+A +LAGL YPL+G+ HAAG+LDD ++ Sbjct 1721 QAAGAAELVDELKRAGASASVLACDVADRDAVATMLAGLPAGYPLRGIVHAAGILDDGLL 1780 Query 1791 TGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLD 1850 + LTPDRVD VLRAKVDGAWNLHELT+D+DLSAFVVFSSMAGIVGTP Q NYAAAN+FLD Sbjct 1781 SSLTPDRVDAVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGTPGQANYAAANSFLD 1840 Query 1851 GLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTAL 1910 GLVA+RR+ GLAGLS+AWGLWEQASAMT HLG+RD+ARM++ GLAPL+TEQAL D A+ Sbjct 1841 GLVAHRRADGLAGLSLAWGLWEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAAM 1900 Query 1911 QADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALT 1970 + V+VAARLDRAAL+ AALP L +LAAGPTRR ID AD SMSGL +RLH L+ Sbjct 1901 LVETPVLVAARLDRAALSENIAALPPLLRELAAGPTRRVIDDADVTASMSGLAARLHGLS 1960 Query 1971 PERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLS 2030 PE R+REL DLV NAA VLG + DINA +AFQDLGFDSLTAVELRNRLK ATGLTLS Sbjct 1961 PEARRRELVDLVCGNAAMVLGVPNPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLS 2020 Query 2031 PTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHL 2090 PTLIFDYPTP LAEHLDSRL + G DQ L R +DITREL LL P +++ KA L Sbjct 2021 PTLIFDYPTPVVLAEHLDSRLAGSGGDDQPDLMGRFNDITRELQALLGAPHWNSDDKAVL 2080 Query 2091 RTRLQTMLTSLTTE--------DDDIAAATESQLFAILDEELG 2125 R R+ +L +L D+D+ AATESQLFAILDEELG Sbjct 2081 RARIHGLLGALPAGDGPDSAPLDEDLEAATESQLFAILDEELG 2123 >gi|342860755|ref|ZP_08717405.1| RifB protein [Mycobacterium colombiense CECT 3035] gi|342131779|gb|EGT85036.1| RifB protein [Mycobacterium colombiense CECT 3035] Length=2129 Score = 2816 bits (7301), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1512/2150 (71%), Positives = 1714/2150 (80%), Gaps = 47/2150 (2%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MN E+LVKALR++LK NERLKRENR LA TEPVAVVGM CRYPGGV+SPE LW++V Sbjct 1 MNGNTEELVKALRQALKDNERLKRENRQYLAAATEPVAVVGMACRYPGGVNSPEALWQMV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 GRD VSEFPADRGW++ GLFD DPDAVGKSY RCGGFL+DV FDA FFGIAPSEALA Sbjct 61 VDGRDVVSEFPADRGWNLTGLFDADPDAVGKSYARCGGFLSDVGDFDAAFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDP TLRGS TGVFAG+FHGSYGGQGRVPG LERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPATLRGSATGVFAGIFHGSYGGQGRVPGHLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAY LG +GPAVSVDTACSSSLVALHLA QSLR GECDLAL GGVTVMATPA Sbjct 181 TLSVASGRVAYSLGFEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRAL+ADGRCKAYAGAADGT F+EG GVLVL RLADARR GHPVLA+VRGSAV Sbjct 241 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLADARRHGHPVLAVVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGP+QQRVI AALA+ARLG ADVD+VEGHGTGTTLGDPIEAQA+LATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALANARLGTADVDLVEGHGTGTTLGDPIEAQAVLATY 360 Query 361 GQ-RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSA 419 GQ RP D+PLWLGSIKSN+GHTSAAAG GVIK+VQA+RHGV+PKTLHVD PTPHVDWSA Sbjct 361 GQDRPTDQPLWLGSIKSNMGHTSAAAGAGGVIKVVQAIRHGVMPKTLHVDEPTPHVDWSA 420 Query 420 GAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWV 479 GAVSLLTE R W RPRRAGVSSFGISGTNAHVI+E+ EP A D V VPWV Sbjct 421 GAVSLLTEQRGWPAVERPRRAGVSSFGISGTNAHVIVEQYTP-EPETATRPGDDVVVPWV 479 Query 480 LSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGL 539 LSARS +AL NQA RLLA V AD VR LDVGWSLV TRS F+HRAVVVGAD QL+ GL Sbjct 480 LSARSGEALANQAARLLARVKADPGVRVLDVGWSLVATRSRFEHRAVVVGADGAQLLRGL 539 Query 540 TGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALR 599 T LAAG GA +V GRA VGKT FVFPGQG+QW GMGAQL ++ VFAEH+ RC AL Sbjct 540 TALAAGEQGAGLVVGRAHPVGKTVFVFPGQGSQWRGMGAQLLDSSRVFAEHMQRCADALA 599 Query 600 EHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA 659 +V+WSL+DV+RGAPG PGLDRVDVVQPALWAVMVSLAELWRSVGV PDAVIGHSQGEIA Sbjct 600 AYVDWSLIDVIRGAPGTPGLDRVDVVQPALWAVMVSLAELWRSVGVTPDAVIGHSQGEIA 659 Query 660 AAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVN 719 AAYVAGALSL DAA VVALRSRLLVRL G GGMVSLACG P+AE+L + WG+RLNIA VN Sbjct 660 AAYVAGALSLDDAARVVALRSRLLVRLAGRGGMVSLACGLPRAEQLIAGWGERLNIATVN 719 Query 720 GVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRT 779 GV++VV++GE DA+ ELMQRC+A+ IRARRIDVDYASHSAQVDAIRE L AL G+ PR+ Sbjct 720 GVAAVVVSGEVDALAELMQRCDADNIRARRIDVDYASHSAQVDAIREPLADALHGLAPRS 779 Query 780 STVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIA 839 S VAFFSTVTGE MDTAG++A+YW++SIR VQFERAVR+A D GY+ F+ESSPHPVL+A Sbjct 780 SAVAFFSTVTGEPMDTAGLDADYWFQSIRHTVQFERAVRSACDAGYQAFIESSPHPVLMA 839 Query 840 GIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRR 899 IE+T+ D +R VIP+LGRDDGG+ RFWLSA QAHV GV VDWRAA A LGGR Sbjct 840 AIEDTMPDSERA-----WVIPSLGRDDGGLDRFWLSAAQAHVFGVAVDWRAAMAGLGGRA 894 Query 900 VELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVA 959 V+LPTY F RQ FWL G A D+ +GL AEHGLL AVV RPDSGGVVLTGR+S A Sbjct 895 VDLPTYGFVRQHFWLPGGSAGTQDVTTLGLAAAEHGLLGAVVPRPDSGGVVLTGRLSTAA 954 Query 960 APWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVL-PADGVRVQVVVG 1018 WLADHAVG VLFPG GFVELA+RAGDEVG +VL ELTL APL+L PA GV+VQ+VVG Sbjct 955 QAWLADHAVGETVLFPGAGFVELAIRAGDEVGATVLDELTLSAPLLLPPAGGVQVQLVVG 1014 Query 1019 GVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADG 1078 +++G+R + VYSA + DS WTLHA+G+L G+V P A+LS+WPP GA A+DV Sbjct 1015 APDEAGSRPLSVYSAGAEPDSE--WTLHAEGLLRPGTVTPGADLSIWPPAGATAVDVTGA 1072 Query 1079 YQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWG 1136 Y LA RGY YG AFRGL+A+W+RG E+FA+V +P+ G GFG+HP +LDAALHA G Sbjct 1073 YARLAQRGYDYGGAFRGLRAMWQRGDELFAEVVVPDDAGTQDGGFGLHPVLLDAALHAIG 1132 Query 1137 IVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVR 1196 + + QT+LPFSWQGV LHASGA+R RVR+AP G G+VSVELAD GLPVLSVR L +R Sbjct 1133 VAAEQDQTLLPFSWQGVSLHASGASRARVRIAPAGAGSVSVELADGTGLPVLSVRSLAMR 1192 Query 1197 PVSAAALS-----RSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLA 1251 PVSA L+ RS A GLL++ W+P+ L G D G A +WEL H GGDV+ Sbjct 1193 PVSAEQLTAAPAQRSRA--EGLLDVTWSPIALGGADSGAGATLWELGDH-----GGDVVK 1245 Query 1252 AVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHP 1311 AV+ E+L LQSWL + G+ V TRGAV ++V+DLAGAAVWGLVRSAQAEHP Sbjct 1246 AVHAAAAEILAALQSWLRDENAGVLAVQTRGAVALAGEEVSDLAGAAVWGLVRSAQAEHP 1305 Query 1312 GRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGW 1369 GR+VL+D+DGS+ + GEPQ+VVR+G YAARL PV G LPSA+ W Sbjct 1306 GRMVLIDSDGSLDAAAVI----DCGEPQVVVRQGTAYAARLRPVRVGPVAALPSAA---W 1358 Query 1370 RLVAGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGA 1429 RL AGG GTL D+VV+ EL GQVRVAV AVGVNFRDVLVALGMYPGGG+LG +G+ Sbjct 1359 RLDAGGEGTLQDLVVSACPRTELTGGQVRVAVAAVGVNFRDVLVALGMYPGGGQLGAEGS 1418 Query 1430 GVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAF 1489 GVVVEVGP VTGLAVGD VMGLLG+VGSEAVVD R+VT VP G SLV AA VPV FLTA Sbjct 1419 GVVVEVGPDVTGLAVGDAVMGLLGVVGSEAVVDHRVVTPVPPGLSLVAAAGVPVVFLTAL 1478 Query 1490 YGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIH 1549 YGLSVL + AG++VLVH TGGVGMAAV LAR+WGAEVFVTAS KWDTLRAMGFDD H Sbjct 1479 YGLSVLGGLRAGERVLVHTATGGVGMAAVQLARHWGAEVFVTASSGKWDTLRAMGFDDDH 1538 Query 1550 ISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQT 1609 I DSR+ EFE F AT G+G DVVLNSLAGEFTDASLRLL GGRFIE+GKTD+RD Sbjct 1539 IGDSRTTEFETKFGSATGGAGFDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPHA 1598 Query 1610 VAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVS 1669 VA+ + G YRAFDL+EAGPDR AAML+E+VGLL A VL LP+KTFD RCA AAYR+VS Sbjct 1599 VADEYHGAVYRAFDLMEAGPDRTAAMLAEIVGLLTADVLKPLPLKTFDVRCASAAYRYVS 1658 Query 1670 QARHIGKVVLTIPDGP-----GGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVL 1724 QARHIGKV LT+ GP G GLA +VV+TGGTGMAGSA+A HLV R+ VA++VL Sbjct 1659 QARHIGKVALTVGSGPGEVLSGCGGGLADASVVITGGTGMAGSALARHLVDRYRVAHVVL 1718 Query 1725 VSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGV 1784 VSR+G +A E+ A L+ GAQV+VV+CDVAD +A +A+L + +YPL+G+ HAAG+ Sbjct 1719 VSRTGARAAGVDELVAGLQNAGAQVSVVACDVADPEAASAMLTQIPAQYPLRGIVHAAGI 1778 Query 1785 LDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAA 1844 LDD +I+ LTPDRVD VLRAKVDGAWNLHELT +DLSAFVVFSSMAGIVGTP Q NYAA Sbjct 1779 LDDGLISSLTPDRVDAVLRAKVDGAWNLHELTRHLDLSAFVVFSSMAGIVGTPGQANYAA 1838 Query 1845 ANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALG 1904 AN+FLDGL AYRR+ GLAGLS+AWGLWEQASAMT HLG+RD+ARM++ GLAPL+TEQAL Sbjct 1839 ANSFLDGLAAYRRAHGLAGLSLAWGLWEQASAMTAHLGDRDKARMSRIGLAPLSTEQALA 1898 Query 1905 FLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVS 1964 D A+ + ++VAAR+DRAAL+ AALP L +L AGPTRR ID D + S +GL + Sbjct 1899 AFDAAMLVETPMLVAARVDRAALSDNIAALPPLLRELVAGPTRRVIDDTDVSASSTGLAA 1958 Query 1965 RLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTA 2024 RLH LTPE RQREL DLV NAA VLG + DI+A +AFQ+LGFDSLTAVELRNRLK A Sbjct 1959 RLHGLTPEARQRELVDLVCGNAAMVLGVPNPADIDAGRAFQELGFDSLTAVELRNRLKNA 2018 Query 2025 TGLTLSPTLIFDYPTPATLAEHLDSRLV-TASGSDQQSLSDRVDDITRELVVLLDQPDLS 2083 TGLTLSPTLIFDYPTP LA HLD++L TA DQ +L R +DITREL LL P + Sbjct 2019 TGLTLSPTLIFDYPTPTVLAAHLDTQLAGTAGAGDQPNLMGRFNDITRELQALLGAPTWN 2078 Query 2084 ANVKAHLRTRLQTMLTSL--------TTEDDDIAAATESQLFAILDEELG 2125 A+ K+ LR R+ +L +L DDD+ AATESQLFAILDEELG Sbjct 2079 ADDKSVLRARIHNLLAALPPGDDSDAEHLDDDLDAATESQLFAILDEELG 2128 >gi|183982485|ref|YP_001850776.1| polyketide synthase Pks7 [Mycobacterium marinum M] gi|183175811|gb|ACC40921.1| polyketide synthase Pks7 [Mycobacterium marinum M] Length=2120 Score = 2796 bits (7249), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1504/2138 (71%), Positives = 1702/2138 (80%), Gaps = 30/2138 (1%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 M+STP++L+ ALR++LK+NERLKRENRD LA+ TEPVAVVGMGCRYPGG+++PE LWE+V Sbjct 1 MDSTPDELITALRKTLKENERLKRENRDHLAQATEPVAVVGMGCRYPGGIETPEGLWEMV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 A GRD VS+FP DRGWD A LFDPDPDAVGKSYTR GGFLTDVAGFDAEFFGIAPSE +A Sbjct 61 AAGRDVVSDFPTDRGWDGASLFDPDPDAVGKSYTRSGGFLTDVAGFDAEFFGIAPSEVMA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALER GIDP TLRGS TGVF GVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERTGIDPTTLRGSATGVFVGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGL+GPAVSVDTACSSSLVALHLAVQSLR ECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSRECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAF+EGAG LVL RL DA+RLGHPVLA+VRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFSEGAGALVLERLTDAQRLGHPVLAVVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGP+QQRVI AALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQR---PADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDW 417 GQ P PLWLGSIKSN+GHTSAAAGVAGVIKM AM+HGVLP+TLHVDVPTPHVDW Sbjct 361 GQDRTGPGKEPLWLGSIKSNMGHTSAAAGVAGVIKMTLAMQHGVLPQTLHVDVPTPHVDW 420 Query 418 SAGAVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVP 477 SAG+VSLLTE RPW GR RRAG+SSFGISGTNAHVILE+APA E V A H D P Sbjct 421 SAGSVSLLTEARPWPETGRARRAGISSFGISGTNAHVILEQAPAAEEVAAQHRTD--LTP 478 Query 478 WVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLME 537 W+L+ARSA AL NQARRL WV ++ DVGWSL TRS+F+HRAVVVGADRTQL++ Sbjct 479 WILAARSAPALVNQARRLAQWVSDRPDLDVADVGWSLATTRSVFEHRAVVVGADRTQLIQ 538 Query 538 GLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERA 597 GL G G P A VV GRA+ VGKT FVFPGQG+QW+GMG L T+ VFA+ +HRCE+A Sbjct 539 GLAGFVDGEPRAGVVVGRARPVGKTVFVFPGQGSQWVGMGVDLLDTSTVFADQMHRCEKA 598 Query 598 LREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGE 657 L E+V WSLLDV+R PGAPGL+RVDVVQP LWA+MVSLAELWRS GV+PDAVIGHSQGE Sbjct 599 LAEYVSWSLLDVVRAVPGAPGLNRVDVVQPVLWAIMVSLAELWRSAGVLPDAVIGHSQGE 658 Query 658 IAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAA 717 IAAAYVAGALSL DAA VVA RS+LLV+L GAGGMVSLACG +A +L + W DRL+IAA Sbjct 659 IAAAYVAGALSLEDAARVVARRSQLLVQLSGAGGMVSLACGLERARQLVASWSDRLSIAA 718 Query 718 VNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEP 777 VNGVS++V++GE DA+ L+ RCEA+ IRARRIDVDYASHSAQV+AIR EL AL GI P Sbjct 719 VNGVSAIVVSGEVDALDALIGRCEADDIRARRIDVDYASHSAQVEAIRAELAEALDGIAP 778 Query 778 RTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVL 837 ++++ AF STVTGE DTAG++A+YW+RSIRQ VQFERA+R AF+ G +VF+ESSPHPVL Sbjct 779 QSTSTAFISTVTGEFTDTAGLDADYWHRSIRQTVQFERAIRTAFNSGCQVFIESSPHPVL 838 Query 838 IAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGG 897 +AGIEETL + +GE IVIP+LGRDDGG+ RFWLS QAHVAGV VDW + G Sbjct 839 MAGIEETL--AGQQDSGEAIVIPSLGRDDGGLQRFWLSVAQAHVAGVRVDWASIIG--AG 894 Query 898 RRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISV 957 RRV LPTY F +RFWL L A D+GG+G GA HGLL AVV+RPDSGGVVLTG++SV Sbjct 895 RRVALPTYGFQHRRFWLGQLDAGRTDVGGLGQAGAAHGLLGAVVERPDSGGVVLTGQLSV 954 Query 958 VAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVV 1017 PWLA HAV VLFPG GFVELA+RAGDEVGC+ ++ELTL APLVLP G VV Sbjct 955 ALQPWLAGHAVAGTVLFPGAGFVELAIRAGDEVGCAAVEELTLSAPLVLPTVGGVQLQVV 1014 Query 1018 GG-VEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVA 1076 G +QS R V VYS Q+ S W+LHA+GVL +V +L+ WPP GA A+D+ Sbjct 1015 VGPADQSDHRTVEVYSRGDQSLSE--WSLHAEGVLAPAAVASVGQLTAWPPEGATALDLG 1072 Query 1077 DGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHA 1134 Y LAARGY YGPAFRGLQA+W G E+FA+V LPE G I GFGIHPA+LDAALHA Sbjct 1073 GVYDRLAARGYEYGPAFRGLQAVWESGDEIFAEVALPEDAGAQIGGFGIHPALLDAALHA 1132 Query 1135 WGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLM 1194 + + QT+LPF+WQGV LHA+GA+R RVR+A G+V++ELAD GLPVL+VR L Sbjct 1133 LVLTAEQNQTVLPFAWQGVSLHAAGASRCRVRIAQSRSGSVAMELADSAGLPVLTVRDLA 1192 Query 1195 VRPVSAAALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAV 1253 RPVS S TAG GLLE++W+P+ G D D V +W+L AG + + Sbjct 1193 FRPVSDQTSSAGTAGGGGLLEVVWSPLARPGDDTADIPVTLWDLASQVELSAGA--VEST 1250 Query 1254 YRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGR 1313 Y H L LQSWLASD G+ VVT GAVG D+DVTDLAG+AVWGLVRSAQAEHPGR Sbjct 1251 YVATHGALGALQSWLASDQPGVLAVVTHGAVGLADEDVTDLAGSAVWGLVRSAQAEHPGR 1310 Query 1314 VVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVA 1373 VVLVDTDGSV +G SGEPQLVVR G Y ARL P + L LP WRLV Sbjct 1311 VVLVDTDGSV----ELGAVLNSGEPQLVVRAGVAYQARLKPAESLLRLPPPGE-NWRLVT 1365 Query 1374 GGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVV 1433 GGGGTL DV V AP L TGQ+RVAV AVGVNFRDVLVALGMYPGGGELGV+GAG+V Sbjct 1366 GGGGTLDDVKVGGCAPSGLMTGQLRVAVAAVGVNFRDVLVALGMYPGGGELGVEGAGIVT 1425 Query 1434 EVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLS 1493 EVGPGV+G+AVGD VMGLLG+VG EAVVD RLVT VP GWSL AA+VPV FLTAFYGL Sbjct 1426 EVGPGVSGVAVGDAVMGLLGVVGPEAVVDHRLVTAVPPGWSLQTAASVPVVFLTAFYGLR 1485 Query 1494 VLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDS 1553 VLAEV +GQK+LVHA TGGVGMAAV LAR WG EVF TAS KWDTLRAMGFDD HI++S Sbjct 1486 VLAEVRSGQKLLVHAATGGVGMAAVQLARLWGLEVFATASPGKWDTLRAMGFDDDHIANS 1545 Query 1554 RSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAER 1613 R+LEFEE F T G GVD VLNSLAGEF DASLRLL GGRFIE+GKTD+RD QT+AE+ Sbjct 1546 RTLEFEEKFRAGTGGVGVDAVLNSLAGEFVDASLRLLVPGGRFIEMGKTDLRDPQTMAEQ 1605 Query 1614 HRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARH 1673 HRGV YRAFDL+EAGPD IA ML+E+ LL A L LP+KTFD R A AYRFVSQARH Sbjct 1606 HRGVGYRAFDLIEAGPDLIARMLAELSRLLCAETLTPLPIKTFDVRLARQAYRFVSQARH 1665 Query 1674 IGKVVLTIPDGPGG--QSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQ 1731 IGKVVLT+PD G LAGGTV++TGGTGMAG+A+A H+V RH VAN++LVSRSG Q Sbjct 1666 IGKVVLTLPDETGAVPAGALAGGTVIITGGTGMAGTALARHVVSRHRVANVILVSRSGAQ 1725 Query 1732 ADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVIT 1791 A+ +E+ L++ GA+ AVV+CDV+DRDA+A LLA + RYPL+GV HAAGVLDD +I Sbjct 1726 AEGTSELLGQLQDAGAEAAVVACDVSDRDAVAELLAQVPARYPLRGVIHAAGVLDDGLIA 1785 Query 1792 GLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDG 1851 LTP RVDTVLRAK+DGAWNLHELT ++LSAFV+FSSMAGI+GT QGNYAAAN+FLDG Sbjct 1786 SLTPQRVDTVLRAKIDGAWNLHELTRGLNLSAFVLFSSMAGIIGTAGQGNYAAANSFLDG 1845 Query 1852 LVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQ 1911 L +RR+ GL G+SVAWGLWEQASAMTRHLGERD+ARM++ GLA L+TE AL D A+ Sbjct 1846 LAVHRRALGLPGVSVAWGLWEQASAMTRHLGERDKARMSRVGLATLSTEHALELFDAAVV 1905 Query 1912 ADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI---DAADTAVSMSGLVSRLHA 1968 ADRAVVVA RLD AL AALP L +LAA P RR I DA D + +GLV+RLH Sbjct 1906 ADRAVVVATRLDANALKSNSAALPPLLGELAARPKRRVISDADAGDNIAAATGLVARLHG 1965 Query 1969 LTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLT 2028 L+ E+RQREL D+V SNAA VLGRSS+ DINAH+AFQ+LGFDSLTAVELRNRLKTATGLT Sbjct 1966 LSAEQRQRELVDVVCSNAATVLGRSSTADINAHRAFQELGFDSLTAVELRNRLKTATGLT 2025 Query 2029 LSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKA 2088 LSPTLIFDYP+PA LAEHL RL TA+ Q L R DD+ REL L+++PD + K Sbjct 2026 LSPTLIFDYPSPAALAEHLGIRLATATA--QPDLMRRFDDLARELDKLINRPDWTHEDKG 2083 Query 2089 HLRTRLQTMLTSLTTEDDDIAAATESQLFAILDEELGS 2126 L RL +L L+ DDDI A+ESQLFAILDEELGS Sbjct 2084 KLSGRLHDILADLSA-DDDITTASESQLFAILDEELGS 2120 >gi|289753750|ref|ZP_06513128.1| polyketide synthase [Mycobacterium tuberculosis EAS054] gi|289694337|gb|EFD61766.1| polyketide synthase [Mycobacterium tuberculosis EAS054] Length=1427 Score = 2795 bits (7246), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1425/1427 (99%), Positives = 1425/1427 (99%), Gaps = 0/1427 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQR ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRSADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPW L Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWGL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLA 1380 Query 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVD 1427 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVD Sbjct 1381 DVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVD 1427 >gi|41407468|ref|NP_960304.1| Pks7 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41395820|gb|AAS03687.1| Pks7 [Mycobacterium avium subsp. paratuberculosis K-10] Length=2018 Score = 2617 bits (6784), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1409/2003 (71%), Positives = 1595/2003 (80%), Gaps = 38/2003 (1%) Query 141 IDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAV 200 + P TLRGS TGVFAG+FHGSYGGQGRVPG+LERYGLRGSTLSVASGRVAY LGL+GPAV Sbjct 35 LTPRTLRGSATGVFAGIFHGSYGGQGRVPGNLERYGLRGSTLSVASGRVAYALGLEGPAV 94 Query 201 SVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAY 260 SVDTACSSSLVALHLA QSLR GECDLAL GGVTVMATPAMFIEFSRQRAL+ADGRCKAY Sbjct 95 SVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPAMFIEFSRQRALAADGRCKAY 154 Query 261 AGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRV 320 AGAADGT F+EG GVLVL RL+DARRLGH VLA++RGSAVNQDGASNGLATPNGP+QQRV Sbjct 155 AGAADGTGFSEGVGVLVLERLSDARRLGHSVLAVLRGSAVNQDGASNGLATPNGPSQQRV 214 Query 321 ITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RPADRPLWLGSIKSNIG 379 I AALA+ARLG ADVD+VEGHGTGT LGDPIEAQA+LATYGQ RP D PLWLGSIKSN+G Sbjct 215 IRAALANARLGAADVDLVEGHGTGTMLGDPIEAQALLATYGQDRPVDEPLWLGSIKSNMG 274 Query 380 HTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRR 439 HTSAAAG GVIKMVQA+RHGV+PKTLHVD PTP VDWSAGAVSLLTE RPW RPRR Sbjct 275 HTSAAAGAGGVIKMVQALRHGVMPKTLHVDEPTPQVDWSAGAVSLLTEARPWPARDRPRR 334 Query 440 AGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWV 499 AGVSSFGISGTNAHVI+E+ EP A V VPWVLSARSA+ALTNQA RLLA V Sbjct 335 AGVSSFGISGTNAHVIVEQ---YEPETIAPQGGDVVVPWVLSARSAEALTNQAARLLARV 391 Query 500 GADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTV 559 AD VR LDVGWSLV+TRS F+HRAV+VGAD QL+ L LA G PGA VV GRAQ V Sbjct 392 KADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLLRRLADLAGGQPGAGVVTGRAQPV 451 Query 560 GKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGL 619 GKT FVFPGQG+QW GMGAQL + VFAEH+HRC AL EHV+WSL+DV+RG PGAPGL Sbjct 452 GKTVFVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCAGALAEHVDWSLIDVIRGTPGAPGL 511 Query 620 DRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALR 679 DRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA VAGALSL+DAA VVALR Sbjct 512 DRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAACVAGALSLQDAARVVALR 571 Query 680 SRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQR 739 SRLLVRL G GGMVSLACG+ +AE+L + WG+RLNIA VNG+S+VV++GE DA+TEL+ R Sbjct 572 SRLLVRLSGRGGMVSLACGRSRAEQLIAPWGERLNIATVNGISAVVVSGEVDALTELLDR 631 Query 740 CEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVN 799 C A+ IRARRIDVDYASHS QV+ IR+ L ALRGI PR+S VAFFSTVTGELMDTA ++ Sbjct 632 CAADDIRARRIDVDYASHSVQVEEIRDSLAEALRGIAPRSSAVAFFSTVTGELMDTAALD 691 Query 800 AEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVI 859 +YW+RSIRQ VQFERAVR A + GYR F+E SPHPVL A IEET+ D G+ VI Sbjct 692 GDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPVLTAAIEETMPD-----GGQGCVI 746 Query 860 PTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGA 919 P+LGRDDGG RFWLSAGQA V+GV VDW A LGGRRV+LPTY F RQ FWL G Sbjct 747 PSLGRDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDLPTYGFVRQHFWLPGGST 806 Query 920 VGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGF 979 D+ +GL GAEHGLL AV+ RPDSGGVVLTGR+S A WLADHAVG VLFPG GF Sbjct 807 GSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSAQAWLADHAVGDTVLFPGAGF 866 Query 980 VELALRAGDEVGCSVLQELTLQAPLVLPAD-GVRVQVVVGGVEQSGTRNVWVYSAAGQAD 1038 VELA+RAGDEVGC V+ ELTL APL LPA GVR+Q+VVG +++G R + VYSAA D Sbjct 867 VELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVGAPDEAGRRPLSVYSAAVHQD 926 Query 1039 SSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQA 1098 S W LHA+GVL G+V PA +LS+WPP+GA A+DV GY LA RGY YG AFRGL+A Sbjct 927 SE--WMLHAEGVLRAGTVTPAGDLSIWPPIGATAVDVTGGYARLAQRGYEYGRAFRGLRA 984 Query 1099 LWRRGAEVFADVTLPEGVPI-RGFGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHA 1157 +W+RG E+FA+V LP+ FG+HP +LDAALH G+ + QT+LPFSWQGV LHA Sbjct 985 MWQRGDEIFAEVALPDDAAAGDDFGVHPVLLDAALHVLGVAGEKDQTVLPFSWQGVALHA 1044 Query 1158 SGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRS--TAGDRGLLE 1215 SGA+R RVR+AP G GAVSVELAD GLPVLSVR + +RPVS LS + TA GLL+ Sbjct 1045 SGASRARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRPVSPGQLSAAMGTAQPSGLLD 1104 Query 1216 MIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGL 1275 +IW+P+ L G D+GD+ +WE H GGDV+ +V+ V E L VLQSWL + G+ Sbjct 1105 VIWSPIALGGNDLGDEVTLWEPGEH-----GGDVVKSVHAAVTETLAVLQSWLDGEGGGV 1159 Query 1276 GVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARS 1335 V T GAV +DV+DLAGAAVWGLVRSAQAEHPGR+VL+D+DGS+ + Sbjct 1160 LAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLVLIDSDGSLDARAVI----PC 1215 Query 1336 GEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELATG 1395 GEPQ+VVR+G +AARL P AG TL S G WRL AGG GTL D+VV+ ELA G Sbjct 1216 GEPQVVVRQGVAHAARLRPARAGATLGLPS-GAWRLDAGGEGTLGDLVVSRCPRTELADG 1274 Query 1396 QVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLV 1455 QVRVAV AVGVNFRDVLVALGMYPGGG LG +GAGVVVEVGP VTGLAVGD VMGLLG+V Sbjct 1275 QVRVAVAAVGVNFRDVLVALGMYPGGGRLGAEGAGVVVEVGPAVTGLAVGDPVMGLLGVV 1334 Query 1456 GSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGM 1515 GSEAVVD RL+T VP G SLV AA VPV FLTA YGLSVLA + G++VLVH TGGVGM Sbjct 1335 GSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVLAGLRPGERVLVHTATGGVGM 1394 Query 1516 AAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVL 1575 AAV LAR++GAEVF TASR KWDTLRAMGFDD HI DSRS +FE+ FL AT G+GVDVVL Sbjct 1395 AAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRSPDFEQKFLAATGGAGVDVVL 1454 Query 1576 NSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAM 1635 NSLAGEFTDASLRLL GGRFIE+GKTD+RD VA+R+RG RYRAFDL+EAGPDR AAM Sbjct 1455 NSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPDVVAQRYRGARYRAFDLMEAGPDRTAAM 1514 Query 1636 LSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDG-----PGGQSG 1690 L+E+VGLL GVL LP+KTFD RCA AAYR+VSQARHIGKVVLT+P G G G Sbjct 1515 LAEIVGLLQEGVLTPLPLKTFDVRCASAAYRYVSQARHIGKVVLTVPSGLGEVLSGCGGG 1574 Query 1691 LAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVA 1750 LA TV++TGGTGMAGSA+A HLV R+ V ++VLVSR+G QA AAE+ L+ GA + Sbjct 1575 LAQSTVLITGGTGMAGSALARHLVDRYRVGHVVLVSRTGAQAAGAAELVDELQRAGASAS 1634 Query 1751 VVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAW 1810 V++CDVADRDA+A +LAGL YPL+G+ HAAG+LDD +++ L PDRVD VLRAKVDGAW Sbjct 1635 VLACDVADRDAVATMLAGLPAGYPLRGIVHAAGILDDGLLSSLIPDRVDAVLRAKVDGAW 1694 Query 1811 NLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGL 1870 NLHELT+D+DLSAFVVFSSMAGIVGTP Q NYAAAN+FLDGLVA+RR+ GLAGLS+AWGL Sbjct 1695 NLHELTKDLDLSAFVVFSSMAGIVGTPGQANYAAANSFLDGLVAHRRADGLAGLSLAWGL 1754 Query 1871 WEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGA 1930 WEQASAMT HLG+RD+ARM++ GLAPL+TEQAL D A+ + V+VAARLDRAAL+ Sbjct 1755 WEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAAMLVETPVLVAARLDRAALSEN 1814 Query 1931 GAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVL 1990 AALP L +LAAGPTRR ID AD SMSGL +RLH L+PE R+REL DLV NAA VL Sbjct 1815 IAALPPLLRELAAGPTRRVIDDADVTASMSGLAARLHGLSPEARRRELVDLVCGNAAMVL 1874 Query 1991 GRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSR 2050 G + DINA +AFQDLGFDSLTAVELRNRLK ATGLTLSPTLIFDYPTP LAEHLDSR Sbjct 1875 GVPNPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLSPTLIFDYPTPVVLAEHLDSR 1934 Query 2051 LVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTSLTTE------ 2104 L + G DQ L R +DITREL LL +++ KA LRTR+ +L +L Sbjct 1935 LAGSGGDDQPDLMGRFNDITRELQALLGAAHWNSDDKAVLRTRIHGLLGALPAGDGPDSA 1994 Query 2105 --DDDIAAATESQLFAILDEELG 2125 D+D+ AATESQLFAILDEELG Sbjct 1995 PLDEDLEAATESQLFAILDEELG 2017 >gi|254550669|ref|ZP_05141116.1| polyketide synthase pks7 [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=1290 Score = 2551 bits (6612), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1290/1290 (100%), Positives = 1290/1290 (100%), Gaps = 0/1290 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 Query 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDD 1290 LEVLQSWLASDATGLGVVVTRGAVGPVDDD Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDD 1290 >gi|336457822|gb|EGO36816.1| polyketide synthase family protein [Mycobacterium avium subsp. paratuberculosis S397] Length=1941 Score = 2541 bits (6585), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1371/1960 (70%), Positives = 1555/1960 (80%), Gaps = 38/1960 (1%) Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 +ASGRVAY LGL+GPAVSVDTACSSSLVALHLA QSLR GECDLAL GGVTVMATPAMFI Sbjct 1 MASGRVAYALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPAMFI 60 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSRQRAL+ADGRCKAYAGAADGT F+EG GVLVL RL+DARRLGH VLA++RGSAVNQD Sbjct 61 EFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHSVLAVLRGSAVNQD 120 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ- 362 GASNGLATPNGP+QQRVI AALA+ARLG ADVD+VEGHGTGT LGDPIEAQA+LATYGQ Sbjct 121 GASNGLATPNGPSQQRVIRAALANARLGAADVDLVEGHGTGTMLGDPIEAQALLATYGQD 180 Query 363 RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAV 422 RP D PLWLGSIKSN+GHTSAAAG GVIKMVQA+RHGV+PKTLHVD PTP VDWSAGAV Sbjct 181 RPVDEPLWLGSIKSNMGHTSAAAGAGGVIKMVQALRHGVMPKTLHVDEPTPQVDWSAGAV 240 Query 423 SLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSA 482 SLLTE RPW RPRRAGVSSFGISGTNAHVI+E+ EP A V VPWVLSA Sbjct 241 SLLTEARPWPARDRPRRAGVSSFGISGTNAHVIVEQ---YEPETIAPQGGDVVVPWVLSA 297 Query 483 RSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGL 542 RSA+ALTNQA RLLA V AD VR LDVGWSLV+TRS F+HRAV+VGAD QL+ L L Sbjct 298 RSAEALTNQAARLLARVKADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLLRRLADL 357 Query 543 AAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHV 602 A G PGA VV GRAQ VGKT FVFPGQG+QW GMGAQL + VFAEH+HRC AL EHV Sbjct 358 AGGQPGAGVVTGRAQPVGKTVFVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCAGALAEHV 417 Query 603 EWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAY 662 +WSL+DV+RG PGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA Sbjct 418 DWSLIDVIRGTPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAC 477 Query 663 VAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVS 722 VAGALSL+DAA VVALRSRLLVRL G GGMVSLACG+ +AE+L + WG+RLNIA VNG+S Sbjct 478 VAGALSLQDAARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGERLNIATVNGIS 537 Query 723 SVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTV 782 +VV++GE DA+TEL+ RC A+ IRARRIDVDYASHS QV+ IR+ L ALRGI PR+S V Sbjct 538 AVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAEALRGIAPRSSAV 597 Query 783 AFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIE 842 AFFSTVTGELMDTA ++ +YW+RSIRQ VQFERAVR A + GYR F+E SPHPVL A IE Sbjct 598 AFFSTVTGELMDTAALDGDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPVLTAAIE 657 Query 843 ETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVEL 902 ET+ D G+ VIP+LGRDDGG RFWLSAGQA V+GV VDW A LGGRRV+L Sbjct 658 ETMPD-----GGQGCVIPSLGRDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDL 712 Query 903 PTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPW 962 PTY F RQ FWL G D+ +GL GAEHGLL AV+ RPDSGGVVLTGR+S A W Sbjct 713 PTYGFVRQHFWLPGRSTGSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSAQAW 772 Query 963 LADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAD-GVRVQVVVGGVE 1021 LADHAVG VLFPG GFVELA+RAGDEVGC V+ ELTL APL LPA GVR+Q+VVG + Sbjct 773 LADHAVGDTVLFPGAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVGAPD 832 Query 1022 QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQV 1081 ++G R + VYSAA DS W LHA+GVL G+V PA +LS+WPP+GA A+DV GY Sbjct 833 EAGRRPLSVYSAAVHQDSE--WMLHAEGVLRAGTVTPAGDLSIWPPIGATAVDVTGGYAR 890 Query 1082 LAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPI-RGFGIHPAVLDAALHAWGIVEG 1140 LA RGY YG AFRGL+A+W+RG E+FA+V LP+ FG+HP +LDAALH G+ Sbjct 891 LAQRGYEYGRAFRGLRAMWQRGDEIFAEVALPDDAAAGDDFGVHPVLLDAALHVLGVAGE 950 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA 1200 + QT+LPFSWQGV LHASGA+R RVR+AP G GAVSVELAD GLPVLSVR + +RPVS Sbjct 951 KDQTVLPFSWQGVALHASGASRARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRPVSP 1010 Query 1201 AALSRS--TAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVH 1258 LS + TA GLL++IW+P+ L G D+GD+ +WE H GGDV+ +V+ V Sbjct 1011 GQLSAAMGTAQPSGLLDVIWSPIALGGNDLGDEVTLWEPGEH-----GGDVVKSVHAAVT 1065 Query 1259 EVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVD 1318 E L VLQSWL + G+ V T GAV +DV+DLAGAAVWGLVRSAQAEHPGR+VL+D Sbjct 1066 ETLAVLQSWLDGEGGGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLVLID 1125 Query 1319 TDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGT 1378 +DGS+ + GEPQ+VVR+G +AARL P AG TL S G WRL AGG GT Sbjct 1126 SDGSLDARAVI----PCGEPQVVVRQGVAHAARLRPARAGATLGLPS-GAWRLDAGGEGT 1180 Query 1379 LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 L D+VV+ ELA GQVRVAV AVGVNFRDVLVALGMYPGGG LG +GAGVVVEVGP Sbjct 1181 LGDLVVSRCPRTELADGQVRVAVAAVGVNFRDVLVALGMYPGGGRLGAEGAGVVVEVGPA 1240 Query 1439 VTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEV 1498 VTGLAVGD VMGLLG+VGSEAVVD RL+T VP G SLV AA VPV FLTA YGLSVLA + Sbjct 1241 VTGLAVGDPVMGLLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVLAGL 1300 Query 1499 AAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEF 1558 G++VLVH TGGVGMAAV LAR++GAEVF TASR KWDTLRAMGFDD HI DSRS +F Sbjct 1301 RPGERVLVHTATGGVGMAAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRSPDF 1360 Query 1559 EEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVR 1618 E+ FL AT G+GVDVVLNSLAGEFTDASLRLL GGRFIE+GKTD+RD VA+R+RG R Sbjct 1361 EQKFLAATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPDVVAQRYRGAR 1420 Query 1619 YRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVV 1678 YRAFDL+EAGPDR AAML+E+VGLL GVL LP+KTFD RCA AAYR+VSQARHIGKVV Sbjct 1421 YRAFDLMEAGPDRTAAMLAEIVGLLQEGVLTPLPLKTFDVRCASAAYRYVSQARHIGKVV 1480 Query 1679 LTIPDG-----PGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQAD 1733 LT+P G G GLA TV++TGGTGMAGSA+A HLV R+ V ++VLVSR+G QA Sbjct 1481 LTVPSGLGEVLSGCGGGLAQSTVLITGGTGMAGSALARHLVDRYRVGHVVLVSRTGAQAA 1540 Query 1734 RAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGL 1793 AAE+ L+ GA +V++CDVADRDA+A +LAGL YPL+G+ HAAG+LDD +++ L Sbjct 1541 GAAELVDELQRAGASASVLACDVADRDAVATMLAGLPAGYPLRGIVHAAGILDDGLLSSL 1600 Query 1794 TPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLV 1853 PDRVD VLRAKVDGAWNLHELT+D+DLSAFVVFSSMAGIVGTP Q NYAAAN+FLDGLV Sbjct 1601 IPDRVDAVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGTPGQANYAAANSFLDGLV 1660 Query 1854 AYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQAD 1913 A+RR+ GLAGLS+AWGLWEQASAMT HLG+RD+ARM++ GLAPL+TEQAL D A+ + Sbjct 1661 AHRRADGLAGLSLAWGLWEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAAMLVE 1720 Query 1914 RAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPER 1973 V+VAARLDRAAL+ AALP L +LAAGPTRR ID AD SMSGL +RLH L+PE Sbjct 1721 TPVLVAARLDRAALSENIAALPPLLRELAAGPTRRVIDDADVTASMSGLAARLHGLSPEA 1780 Query 1974 RQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTL 2033 R+REL DLV NAA VLG + DINA +AFQDLGFDSLTAVELRNRLK ATGLTLSPTL Sbjct 1781 RRRELVDLVCGNAAMVLGVPNPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLSPTL 1840 Query 2034 IFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTR 2093 IFDYPTP LAEHLDSRL + G DQ L R +DITREL LL +++ KA LRTR Sbjct 1841 IFDYPTPVVLAEHLDSRLAGSGGDDQPDLMGRFNDITRELQALLGAAHWNSDDKAVLRTR 1900 Query 2094 LQTMLTSLTTE--------DDDIAAATESQLFAILDEELG 2125 + +L +L D+D+ AATESQLFAILDEELG Sbjct 1901 IHGLLGALPAGDGPDSAPLDEDLEAATESQLFAILDEELG 1940 >gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342131778|gb|EGT85035.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=2121 Score = 2382 bits (6174), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1333/2153 (62%), Positives = 1561/2153 (73%), Gaps = 76/2153 (3%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 V L+R R +R +L + EPVAVVGM CRY GGV+SPE LW+LV GRD VS Sbjct 8 VDYLKRLTADLRRTRRRVAELEGQLFEPVAVVGMACRYAGGVESPEDLWQLVIEGRDTVS 67 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 +FPADRGWDV GL+DPDPDA GK YTR G FL D FDA FFGI PSEALAMDPQQR++ Sbjct 68 DFPADRGWDVEGLYDPDPDAKGKMYTRQGSFLQDAGDFDAGFFGIGPSEALAMDPQQRMM 127 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LE+ WEALERAGIDP LRGS TGVFAGV H YGG+ V G+LE YGL GSTLSV SGR Sbjct 128 LEICWEALERAGIDPFALRGSATGVFAGVIHAGYGGE--VKGELEGYGLTGSTLSVTSGR 185 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 V+YVLGL+GPAVSVDTACSSSLV++HLA QSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 186 VSYVLGLEGPAVSVDTACSSSLVSMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 245 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 RAL+ DGRCK YAGAADGT+++EGAGVLVL RLADARRLGHPVLA++RG+AVNQDGASNG Sbjct 246 RALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVLAVLRGTAVNQDGASNG 305 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RPADR 367 L PNGP+QQRVI AALA+A L ADVDVVEGHGTGT LGDPIEAQA+LATYGQ RPADR Sbjct 306 LTAPNGPSQQRVIRAALANAGLAAADVDVVEGHGTGTVLGDPIEAQALLATYGQDRPADR 365 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGSIKSNIGHTSAAAGVAGVIKMVQA+RHGV+PKTLHVDVP+PHVDW++GAVSLLTE Sbjct 366 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAIRHGVMPKTLHVDVPSPHVDWTSGAVSLLTE 425 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPA-----VEPVGAAHGNDPVAVPWVLSA 482 P+PW G RRAGVSSFGISGTNAHVI+E+APA EPV A ++PV +PWV+SA Sbjct 426 PQPWPDHGGIRRAGVSSFGISGTNAHVIVEQAPAQLDSDAEPV--AGPSNPV-IPWVISA 482 Query 483 RSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGL 542 RS +AL QA+RLL + AD + R +DVGWSL R+ F+HRAV++G DR L GL GL Sbjct 483 RSPEALAGQAQRLLDRLSADADARAVDVGWSLATNRAAFEHRAVLIGRDREALTTGLAGL 542 Query 543 AAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHV 602 A+G P + GR + GK FVFPGQG+Q LGMGA+L P FA+ A+ H Sbjct 543 ASGRPDPGALVGRTRPAGKRVFVFPGQGSQSLGMGAELYDRFPAFAQAFDEAVAAVDAHA 602 Query 603 EWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAY 662 L +V+ G L + QPAL+ V ++LA LW+S G+ PD VIGHS GEIAAA Sbjct 603 RLPLREVMWGT-DPELLQSTEFAQPALFVVEIALAALWQSFGITPDVVIGHSVGEIAAAC 661 Query 663 VAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVS 722 VAGA+ L DAA +VA R RL+ L G MV+++ + + L + ++IAAVNG Sbjct 662 VAGAMPLPDAARLVAARGRLMAGLPAGGVMVAVSATEAEVAGLLN---GAVSIAAVNGPR 718 Query 723 SVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTV 782 S+VL+GE DAV + R A G R R+ V +A HS ++ + E A G+ + Sbjct 719 SLVLSGERDAVGAVADRLAAGGARVHRLAVSHAFHSPLMEPMMGEFAAVAAGVSAGQPRI 778 Query 783 AFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIE 842 A S +TG+L A YW +R+PV+F V+ A G VF+E P L + +E Sbjct 779 ALVSNLTGQLAGPDYGTAGYWVDHVRKPVRFVDGVQLAESLGAGVFLEVGPGAALTSAVE 838 Query 843 ETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVEL 902 ++L T + ++ +D V +AGQ AG V W AAFAD RRVEL Sbjct 839 QSLT------TERATSVVSMAKDRPEVDSLLRAAGQLFTAGADVRWAAAFADGWARRVEL 892 Query 903 PTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPW 962 PTYAF R+RFWL ++ +GL AEH LL AVV RPDSGGVVLTGR+S+ A PW Sbjct 893 PTYAFVRRRFWLSSDSVGSANIASLGLAEAEHALLGAVVDRPDSGGVVLTGRLSIAAQPW 952 Query 963 LADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGV-RVQVVVGGVE 1021 LADHAV VLFPG GFVELALRAGDEVGCSV++ELTL APLV+PA GV +QVVV G Sbjct 953 LADHAVAGTVLFPGAGFVELALRAGDEVGCSVVEELTLAAPLVVPAAGVVHLQVVVAGAG 1012 Query 1022 QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQV 1081 +GTR V VYS A Q+D W LHA+GVL G+ P +LSVWPP GA A+DV Y Sbjct 1013 DAGTRTVTVYSRAAQSD----WVLHAEGVLSGGAPAPDTDLSVWPPPGADAVDVTGAYDG 1068 Query 1082 LAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVE 1139 LA RGYGYGPAFRGL+ +WRRG E FA+V LPE GV GFGIHP +LDAALHA G+ + Sbjct 1069 LAGRGYGYGPAFRGLRTVWRRGTETFAEVELPEQAGVATGGFGIHPVLLDAALHALGVAD 1128 Query 1140 GEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVS 1199 +T+LPFSWQGVCL+A+GA+RVRVRLAPVG GAVSVELAD GLPVLSVR+L+ R VS Sbjct 1129 ERIETVLPFSWQGVCLNAAGASRVRVRLAPVGAGAVSVELADSSGLPVLSVRELVTRAVS 1188 Query 1200 AAALS-----RSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVY 1254 A L+ RS +G+ LL+++W+PV G D+G D VWE PP AG + +VY Sbjct 1189 ADQLAAAVAARSGSGE--LLDVVWSPVSPPGNDVGSDITVWESPP-----AGPGAVGSVY 1241 Query 1255 RGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRV 1314 R HE L VLQSWL ++ G+ VV+TRGAVG +DV DLAGAAVWGL RSAQAEHPGRV Sbjct 1242 RATHEALGVLQSWLTAEQAGVLVVLTRGAVGLAGEDVADLAGAAVWGLTRSAQAEHPGRV 1301 Query 1315 VLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGWRLV 1372 VLVDTDG++ V +G GEPQLVVR G Y+ARL P L LP + WRL Sbjct 1302 VLVDTDGTLDVAAVIG---GCGEPQLVVRDGVAYSARLKPADQRPLLRLPDPPSA-WRLA 1357 Query 1373 AGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVV 1432 AG GTL D+ V P L +GQVRV V A GVNFRDVLVALGMYPG +LG +GAG+V Sbjct 1358 AGDAGTLEDLAVQEYPPAALESGQVRVTVAAAGVNFRDVLVALGMYPGAAQLGAEGAGIV 1417 Query 1433 VEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGL 1492 E+G GV LAVGD VMG+ GL GSEA VD RLVT VP GWS+ +AAAVPV FLTA+YGL Sbjct 1418 TELGAGVADLAVGDAVMGIFGLAGSEAAVDRRLVTRVPRGWSMAQAAAVPVVFLTAYYGL 1477 Query 1493 SVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISD 1552 SVLA + AGQ+VLVHA TGGVGMAAV LAR+WGAEVF TASR KWDTLR MGFDD HI+D Sbjct 1478 SVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTLRVMGFDDAHIAD 1537 Query 1553 SRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAE 1612 SR+L+FE+ F G+DVVLNSLAGEF DASLRLL GGRFIE+GKTD+RD VA Sbjct 1538 SRTLDFEQKF-----AGGMDVVLNSLAGEFNDASLRLLGPGGRFIEMGKTDLRDPDAVAA 1592 Query 1613 RHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQAR 1672 H GV YRAFDL+EAGPDRIA ML+E++ L A GVL LPVK FDAR A AYRFVSQAR Sbjct 1593 DHPGVTYRAFDLMEAGPDRIAEMLAELMDLFARGVLMPLPVKEFDARSAADAYRFVSQAR 1652 Query 1673 HIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQA 1732 H+GKVVLT+PDGP +GLAGGT ++TGGTGMAGSAVA HLV RH V +++LVSRSGE+A Sbjct 1653 HVGKVVLTMPDGP---AGLAGGTALITGGTGMAGSAVARHLVERHRVPHVLLVSRSGERA 1709 Query 1733 DRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITG 1792 A++AA LRE GA V+V +CDV DRDA+A LLA + RYPL+ VFHAAGVLDDAV+ Sbjct 1710 GGMADLAAELRELGASVSVAACDVGDRDAVAELLAQVPARYPLRSVFHAAGVLDDAVLAS 1769 Query 1793 LTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGL 1852 LTP R+DTVLRAKVDGAWNLHELT ++LSAFV FSSMAGIVG P QGNYAAAN+FLD L Sbjct 1770 LTPARIDTVLRAKVDGAWNLHELTGGLNLSAFVAFSSMAGIVGAPGQGNYAAANSFLDAL 1829 Query 1853 VAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQA 1912 A+RR+RGL GLSVAWG+WE+ S MT+HLGERD+ARM++AGL+ L+T QAL LD AL Sbjct 1830 AAHRRTRGLPGLSVAWGMWEETSTMTQHLGERDKARMSRAGLSALSTRQALELLDAALLT 1889 Query 1913 DRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPE 1972 ++ +VVA RLDRAALA G LP L SQLA P RR ++ D VS++GL +RL +TP+ Sbjct 1890 EQPMVVATRLDRAALAHHGDTLPPLLSQLATRPARRVLEHTDM-VSLTGLRARLEGMTPD 1948 Query 1973 RRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPT 2032 +R EL +LV SNAA VLG S + D+NA AF DLGFDSLTAVELRNRLK ATGLTLSPT Sbjct 1949 QRHSELVELVCSNAATVLGHSFA-DVNADDAFGDLGFDSLTAVELRNRLKIATGLTLSPT 2007 Query 2033 LIFDYPTPATLAEHLDSRLVTASGSDQQSLSD-------RVDDITRELVVLLDQPDLSAN 2085 LIFD PTP LAEHL ++L ++ + R +DI REL LL QPDLS Sbjct 2008 LIFDQPTPGALAEHLGAQLAGSAPGAPAIGAAAAPDRMARFNDIARELQALLGQPDLSPG 2067 Query 2086 VKAHLRTRLQTMLTSLTTE-------------DDDIAAATESQLFAILDEELG 2125 KA L TRL+ +L + T DDDIA ATESQLFAILDEE G Sbjct 2068 DKAQLITRLEGLLAAATGRAQAPLLEHPADAFDDDIATATESQLFAILDEEAG 2120 >gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Mycobacterium marinum M] gi|183175812|gb|ACC40922.1| polyketide synthase, Pks8 [Mycobacterium marinum M] Length=2114 Score = 2376 bits (6157), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1354/2139 (64%), Positives = 1584/2139 (75%), Gaps = 55/2139 (2%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 V L+R R +R +L + +EPVA+VGMGCRYPGG DSPE+LWE++ GRDAVS Sbjct 8 VDYLKRLTADLRRTRRRVAELEDKLSEPVALVGMGCRYPGGADSPESLWEMLTQGRDAVS 67 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 EFP+DRGWD+ +FDPDPDA GK+YTR GGFL D FDA FFG+ P+EALAMDPQQRL+ Sbjct 68 EFPSDRGWDIDAMFDPDPDARGKTYTRRGGFLADAGDFDAGFFGVGPNEALAMDPQQRLM 127 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LEVSWEALER+GIDP TLRGS TGVF GV H YGG+ V G+LE YGL GSTLSVASGR Sbjct 128 LEVSWEALERSGIDPTTLRGSATGVFVGVIHAGYGGE--VKGELEGYGLTGSTLSVASGR 185 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 VAYVLGL+GPAVSVDTACSSSLVALHLA QSLR ECDLALVGGVTVMATPA F+EFSRQ Sbjct 186 VAYVLGLEGPAVSVDTACSSSLVALHLAAQSLRSRECDLALVGGVTVMATPAAFVEFSRQ 245 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 RAL+ADG CKAYAGAADGT ++EGAGVLV+ RLADA+RLGHPVLA+VRGSAVNQDGASNG Sbjct 246 RALAADGLCKAYAGAADGTTWSEGAGVLVVERLADAQRLGHPVLAVVRGSAVNQDGASNG 305 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRP 368 L PNGP+QQRVI AALASARLGVADVDVVEGHGTGT LGDPIEAQAILATYGQ + P Sbjct 306 LTAPNGPSQQRVIRAALASARLGVADVDVVEGHGTGTVLGDPIEAQAILATYGQDRTE-P 364 Query 369 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEP 428 LWLGSIKSNIGHTSAAAGVAG+IKMV AM+HGVLP+TLHVDVPTPHVDWSAGAVSLLTE Sbjct 365 LWLGSIKSNIGHTSAAAGVAGLIKMVLAMQHGVLPQTLHVDVPTPHVDWSAGAVSLLTES 424 Query 429 RPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQAL 488 RPW GRPRRAGVSSFGISGTNAHVILE+AP E A VPWVLSARSA AL Sbjct 425 RPWPDLGRPRRAGVSSFGISGTNAHVILEQAPTAEHDLAEPDRGAPTVPWVLSARSAPAL 484 Query 489 TNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPG 548 NQA+RLL+W ++ P+DVGWSL TRSLF+HRAVVVG DRTQLM+GL G+ AG PG Sbjct 485 ANQAQRLLSWAEEHPDLDPVDVGWSLAATRSLFEHRAVVVGTDRTQLMDGLAGVVAGEPG 544 Query 549 ADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLD 608 A VV GRA++ GKT FVFPGQGAQ+LGMG L F+ L H+ L Sbjct 545 AGVVVGRARSTGKTVFVFPGQGAQYLGMGRVLYERFSAFSTAFDAAAAELDAHLRLPLRQ 604 Query 609 VLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALS 668 V+ G L+ + QPAL+AV V+LA L +GVVPD V+GHS GEI+AA+VAG LS Sbjct 605 VMWGTDEGL-LESTEFAQPALFAVEVALAALLSQLGVVPDLVLGHSVGEISAAHVAGVLS 663 Query 669 LRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAG 728 L DAA +VA R RL+ L G MV++A + + L G + +AAVNG SVV++G Sbjct 664 LPDAARLVAARGRLMAGLAAGGAMVAVAASEQEVTPL---LGSGVAVAAVNGPDSVVISG 720 Query 729 ETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTV 788 AV E++ R A G R R+ V +A HS +D + + L+G+ ++ S V Sbjct 721 PEAAVGEVVDRIAALGRRTHRLAVSHAFHSELMDPMLPDFAEVLKGVSASQPRISLVSNV 780 Query 789 TGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDC 848 TG+L + +A YW +R+PV+F +V A G FVE P L A +E++L Sbjct 781 TGQLAEAGYGSAAYWVEHVRKPVRFADSVALAESLGAAAFVEVGPSGGLTALVEQSL--- 837 Query 849 DRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFA 908 T E +P L +D L GQ G +DWR AFA LG +R +LPTY F Sbjct 838 ----TRETPAVPLLIKDRPENDALLLGLGQLFADGRALDWREAFAGLGAQRTDLPTYGFV 893 Query 909 RQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAV 968 R+R+WL LG L G GL G H LL AVV+RPD GG+VLTG +S PWL DH V Sbjct 894 RRRYWLKELGVDQTKLTGAGLTGVGHPLLGAVVERPDVGGLVLTGVLSPELHPWLRDHTV 953 Query 969 GPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTRN 1027 VVLFPG GFVELALRAGDEVGC ++QELTL APL LP G VR+Q+VVGG ++SG R Sbjct 954 DGVVLFPGAGFVELALRAGDEVGCPLVQELTLLAPLALPQTGTVRMQLVVGGADESGRRT 1013 Query 1028 VWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGY 1087 V V+S+ DS W LHA+GVL V +LSVWPPVGA A+DV+D Y AARGY Sbjct 1014 VSVFSSTADGDS---WVLHAEGVLRASGVGHGVDLSVWPPVGASAVDVSDVYDRFAARGY 1070 Query 1088 GYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEGEQQTMLP 1147 GYGPAFRGL+++WRRG E++A+V PE ++GFGIHPAVLDAALHAWG Q MLP Sbjct 1071 GYGPAFRGLRSVWRRGREIYAEVVAPEDATVQGFGIHPAVLDAALHAWGFATATDQLMLP 1130 Query 1148 FSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSRST 1207 FSWQGV LHA+GAAR+RVR+ P G+VS+ELADP+GLPVLSV+QL+VR VS ALS + Sbjct 1131 FSWQGVSLHAAGAARLRVRITPADAGSVSLELADPRGLPVLSVKQLVVRAVSGEALSAAV 1190 Query 1208 AGDRG-----LLEMIWTPVP--LEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 G LLE+ W P L D D VVWE A GDV AV + V+E Sbjct 1191 IAAGGTISGRLLEVAWPPTSPELSASDSARDVVVWE-----SGSADGDV--AVGQRVNEA 1243 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 L LQSWLA D G+ VV+TRGAVG + VTDLAGAAVWGL RSAQAEHPGRVVLVDTD Sbjct 1244 LAKLQSWLAGDDPGVLVVLTRGAVGLAGEGVTDLAGAAVWGLTRSAQAEHPGRVVLVDTD 1303 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPV--AAGLTLPSASAGGWRLVAGGGGT 1378 SV + DAV GEPQLVVR G V+ ARL + +GL LP G WRL GGGGT Sbjct 1304 DSVDIADAVA----CGEPQLVVRSGVVHGARLRFIDSGSGLELPE---GPWRLAVGGGGT 1356 Query 1379 LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 L DV+V P +LA GQVRVAVGA GVNFRDVLVALGMYPGGG LG +GAGVVVEVGPG Sbjct 1357 LEDVLVQPCPRADLAAGQVRVAVGAAGVNFRDVLVALGMYPGGGALGAEGAGVVVEVGPG 1416 Query 1439 VTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEV 1498 V GLAVGD VMGL+G+VGSEAVVD RLVT VPAGWSL +AA VPV FLTAFYGLSVLA + Sbjct 1417 VEGLAVGDAVMGLVGVVGSEAVVDERLVTTVPAGWSLAQAAGVPVVFLTAFYGLSVLAGL 1476 Query 1499 AAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEF 1558 AG++VL+HAG GGVGMAAV+LA+YWGAE+FVTASR KWDTLRAMGFDD HI DSRSLEF Sbjct 1477 KAGERVLIHAGAGGVGMAAVALAKYWGAEIFVTASRGKWDTLRAMGFDDEHIGDSRSLEF 1536 Query 1559 EEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVR 1618 EE F + + G+GVDVVLNSLAGEFTDASLRLL SGGRFIE+GKTD+RD Q VA+ + GV Sbjct 1537 EEKFRKTSGGAGVDVVLNSLAGEFTDASLRLLVSGGRFIEMGKTDLRDPQAVADEYPGVS 1596 Query 1619 YRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVV 1678 YRAFDL+EAGPD IA MLSEVVGLL G+L P+K FD R A AYR+VSQARHIGKVV Sbjct 1597 YRAFDLMEAGPDAIARMLSEVVGLLQEGILKAPPLKLFDVRSAQQAYRYVSQARHIGKVV 1656 Query 1679 LTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEV 1738 LT+P GP QS L+GGTV++TGGTGMAG+AVA HLV+R+GV ++VLVSR+G QA A++ Sbjct 1657 LTLPQGPAAQSVLSGGTVLITGGTGMAGAAVARHLVQRYGVGHVVLVSRAGTQAPGIADL 1716 Query 1739 AALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRV 1798 A L++GGAQV+V +CDVADRDA+AALLA L RYPLKG+FHAAGVLDDAV+ LTPDRV Sbjct 1717 VAELQQGGAQVSVTACDVADRDAVAALLAQLPDRYPLKGIFHAAGVLDDAVLASLTPDRV 1776 Query 1799 DTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRS 1858 + VLRAK GAWNLHELT MDL+AFV+FSS+AGI G P QGNYAAANAFLDGL AYRR Sbjct 1777 EPVLRAKAAGAWNLHELTHGMDLAAFVMFSSLAGIAGAPGQGNYAAANAFLDGLAAYRRG 1836 Query 1859 RGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVV 1918 + L +S+AWGLWEQ S MT+HLG+RD ARM Q GL PL+TE AL LD AL +R VV Sbjct 1837 QDLPAVSIAWGLWEQPSTMTQHLGDRDLARMRQVGLDPLSTEHALHLLDAALLGERPGVV 1896 Query 1919 AARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQREL 1978 AA+L+ AAL+ A +P ++ L RR +DA D + SM+ L+SRLH L+PE+R REL Sbjct 1897 AAQLNVAALS-ANPEVPPIWRDLVTRSVRRVVDANDNSASMTALISRLHTLSPEQRSREL 1955 Query 1979 TDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYP 2038 D++ +NAA VLG ++SVDI+A+K FQDLGFDSLTAVELRNRLK++TGLTLSPTLIFDYP Sbjct 1956 VDMICTNAATVLG-NASVDIDANKPFQDLGFDSLTAVELRNRLKSSTGLTLSPTLIFDYP 2014 Query 2039 TPATLAEHLDSRLVT---ASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQ 2095 TPA LAEHL ++L + A+ +Q + R D + REL ++++PD +A + + RL Sbjct 2015 TPAALAEHLSTQLSSLSPAAADEQPNRLARFDAVARELDSMINEPDWTAEDRERVSNRLH 2074 Query 2096 TMLTSLT---------TEDDDIAAATESQLFAILDEELG 2125 +L LT + DDDI++A+ES+LFAILDEELG Sbjct 2075 GLLADLTSPQSRGEDHSHDDDISSASESELFAILDEELG 2113 >gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118163848|gb|ABK64745.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=2128 Score = 2360 bits (6115), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1343/2156 (63%), Positives = 1562/2156 (73%), Gaps = 69/2156 (3%) Query 6 EDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRD 65 E + L+R R +R +L R +EPVAVVGM CRY GGVDSPE LW+LV GRD Sbjct 5 EQHLDYLKRLTADLRRTRRRVAELEGRLSEPVAVVGMACRYAGGVDSPEALWDLVIEGRD 64 Query 66 AVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQ 125 VS+FP DRGWDV GL+DPDPDA GK YTR G FL FDA FFGI PSEALAMDPQQ Sbjct 65 TVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQGSFLQHAGDFDAGFFGIGPSEALAMDPQQ 124 Query 126 RLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVA 185 R++LE+ WEALERAGIDP LRG+ TGVFAGV H YGG+ V G+LE YGL GSTLSV Sbjct 125 RIMLEICWEALERAGIDPSALRGTATGVFAGVIHAGYGGE--VKGELEGYGLTGSTLSVT 182 Query 186 SGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEF 245 SGRV+YVLGL+GPAVSVDTACSSSLVA+HLA QSLR GECDLAL GGVTVMATPA F+EF Sbjct 183 SGRVSYVLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVEF 242 Query 246 SRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGA 305 SRQRAL+ DGRCK YAGAADGT+++EGAGVLVL RLADARRLGHPV A++RGSAVNQDGA Sbjct 243 SRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWAVLRGSAVNQDGA 302 Query 306 SNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RP 364 SNGL PNGP+QQRVI AALA+A L DVDVVEGHGTGT LGDPIEAQA+LATYGQ RP Sbjct 303 SNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTGTVLGDPIEAQALLATYGQDRP 362 Query 365 ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSL 424 ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQA+RHGV+PKT+HVDVP+PHVDWSAGAVSL Sbjct 363 ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQALRHGVMPKTMHVDVPSPHVDWSAGAVSL 422 Query 425 LTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPV---AVPWVLS 481 LT+PRPW G PRRAGVSSFGISGTNAHVI+E+APA AA + + VPWV+S Sbjct 423 LTDPRPWPEHGGPRRAGVSSFGISGTNAHVIVEQAPAAAETEAAPASSTMPDAVVPWVVS 482 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 ARSA+AL QARRLL V AD PLDVGWSLV+TR++F+HRAVVVG +R L GL G Sbjct 483 ARSAEALAGQARRLLDHVTADAQASPLDVGWSLVSTRAVFEHRAVVVGRERGALATGLAG 542 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA+G PG V GRA++ GKT VFPGQG+Q LGMG QL VFA + + EH Sbjct 543 LASGRPGPATVVGRARSTGKTVLVFPGQGSQTLGMGRQLYERFEVFAGALDEAVAVVDEH 602 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 S+ +V+ GA L + QPAL+ V+LA LW S+GV PD V+GHS GEIAAA Sbjct 603 SRLSVREVMWGA-DPELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAA 661 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 VAG LSLRDAA +VA R L+ L G MV++ G+ Q L G ++IAAVNG Sbjct 662 CVAGVLSLRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPL---LGGGVSIAAVNGP 718 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +VVL+GE +AV + R G R R+ V +A HSA ++ + + AA GIEPR Sbjct 719 DAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAGIEPRPPR 778 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S +TG+L +YW +R+PV+F VR A G VF+E P L + + Sbjct 779 IPLVSNLTGQLAGPGYGTPQYWVDHVRRPVRFVDGVRLAESQGAGVFLEVGPGAALTSAV 838 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 E++L DR + +V GR + V +A + AG V W AAF L RRV+ Sbjct 839 EQSLT-SDRAMS---VVTMPKGRPE--VDSLLTAAARLFTAGADVRWSAAFTGLHARRVD 892 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAFAR+RFWL G ++ +GL AEH LL AV+ RPDSGGVVLTGR+S A P Sbjct 893 LPTYAFARRRFWLSGDAVGSANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQP 952 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADHAV VLFPG GFVELALRAGDEVGC V++ELTL APL LPA G V++QVVV Sbjct 953 WLADHAVAGTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVVADA 1012 Query 1021 E-QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGY 1079 Q G+R+V VYS Q++ WTLHA+GVL + PAAELSVWPP A A+DVA GY Sbjct 1013 AGQPGSRSVAVYSRVAQSE----WTLHAEGVLSEAAPAPAAELSVWPPADAEAVDVAGGY 1068 Query 1080 QVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGI 1137 LA RGYGYGPAFRGL+A+WRRGAE FA+V LPE GV FGIHP +LDAALHA G+ Sbjct 1069 DDLAGRGYGYGPAFRGLRAVWRRGAETFAEVELPEQAGVSTGRFGIHPVLLDAALHALGV 1128 Query 1138 VEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRP 1197 + +T+LPFSWQGV LHA+GA+RVRVRLAP G GAVSVELAD G+PVLSVR+L+ R Sbjct 1129 ADKRLETVLPFSWQGVSLHAAGASRVRVRLAPAGAGAVSVELADASGVPVLSVRELVTRA 1188 Query 1198 VSAAALSRSTA---GDRGLLEMIWTPV----PLEGGDIGDDAVVWELPPHAGAQAGGDVL 1250 VSA L+ + A G LL++ W+ + L I + VWE P A AG Sbjct 1189 VSAEQLAAAVAVRSGSGELLDVAWSVIEPRNSLPDNPISEGVTVWE--PAAVDGAGP--- 1243 Query 1251 AAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEH 1310 AAV+ H+ L VLQS LA +A G+ VV TRGAVG +DV DLAGAAVWGLVRSAQAEH Sbjct 1244 AAVHAATHQALGVLQSRLAGEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQAEH 1303 Query 1311 PGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVA--AGLTLPSASAGG 1368 PGRVVLVDTDGS+ + +G GEPQLVVR G Y ARL P A L LP A Sbjct 1304 PGRVVLVDTDGSLDLATVIG----CGEPQLVVRDGVAYRARLRPAGRRALLELPGPPAV- 1358 Query 1369 WRLVAGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDG 1428 WRL AG GTL D+ V ELA GQVRV V A GVNFRDVLVALGMYPG +LG +G Sbjct 1359 WRLAAGDAGTLEDLAVQEHPAAELAPGQVRVRVAAAGVNFRDVLVALGMYPGAAQLGAEG 1418 Query 1429 AGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTA 1488 AGVV EVG GVT +AVGD VMG+ GLVGSEA VD RLVT VP GWS+ +AA +PV FLTA Sbjct 1419 AGVVTEVGAGVTDVAVGDAVMGIFGLVGSEAAVDRRLVTRVPPGWSMAQAAGIPVVFLTA 1478 Query 1489 FYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDI 1548 +YGLSVLA + AGQ+VLVHA TGGVGMAAV LAR+WGAEVF TASR KWDTLRAMGFDD Sbjct 1479 YYGLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTLRAMGFDDA 1538 Query 1549 HISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQ 1608 HI+DSR+L+FE+ F A G+DVVLNSLAGEF DASLRLL GGRFIE+GKTD+RD Sbjct 1539 HIADSRTLDFEQKFGAAP--GGMDVVLNSLAGEFNDASLRLLGPGGRFIEMGKTDLRDPD 1596 Query 1609 TVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFV 1668 VA H GVRYRAFDL+EAGPDRIAAML+EV+ L AAG L LPVK FDARCA AYRFV Sbjct 1597 VVARAHPGVRYRAFDLMEAGPDRIAAMLAEVMELFAAGALTPLPVKAFDARCAADAYRFV 1656 Query 1669 SQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRS 1728 S ARHIGKVVLT+PDGP +GL+GGT ++TG TGMAG+A+A HLV RH V +L+LV R Sbjct 1657 SAARHIGKVVLTMPDGP---AGLSGGTALITGATGMAGAALARHLVARHRVPHLMLVGRR 1713 Query 1729 GEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDA 1788 GE A AE+AA LR GA V+V+SCDV DRDA+AA+LA + RYPL+ VFHAAGVLDDA Sbjct 1714 GEAAPGMAELAAELRGAGASVSVLSCDVGDRDAVAAMLAQVPARYPLRSVFHAAGVLDDA 1773 Query 1789 VITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAF 1848 VI LTP R+DTVLRAKVDGAWNLHELT+D+DLSAFVVFSSMAGIVG P QGNYAAAN+F Sbjct 1774 VIASLTPARIDTVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGAPGQGNYAAANSF 1833 Query 1849 LDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDT 1908 LD L +R + GL LSVAWG+WE+ SAMT HL ERD+ARM++AGL+ L+T QAL LD Sbjct 1834 LDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKARMSRAGLSALSTRQALDLLDD 1893 Query 1909 ALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHA 1968 AL ++ +VV RLDRAALA AALP L S+LA P RR ++ D VS++GL +RL Sbjct 1894 ALLGEQPLVVGTRLDRAALAQHRAALPPLLSELAGRPARRMLEHTDM-VSLTGLRARLAG 1952 Query 1969 LTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLT 2028 + PE+RQ EL +LV NAAAVLG S++ D++ AF DLGFDSLTAVELRNRLK ATGLT Sbjct 1953 MNPEQRQAELVELVCGNAAAVLGHSTA-DVDPGDAFSDLGFDSLTAVELRNRLKIATGLT 2011 Query 2029 LSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSL--------SDRVDDITRELVVLLDQP 2080 LSPT+IFD+PTPA LAEHL +L +A + S R+D++ EL LL QP Sbjct 2012 LSPTVIFDHPTPAALAEHLGGQLTSAGPTPAAPAETAAPPDRSSRIDEVVSELQTLLTQP 2071 Query 2081 DLSANVKAHLRTRLQTMLTSLTTE-----------DDDIAAATESQLFAILDEELG 2125 LS +A L TRLQ++L++ DDDIA AT+SQLFAILD+E G Sbjct 2072 GLSPGDRAQLVTRLQSLLSTPPQPSGHPEFPEDAFDDDIATATDSQLFAILDDEAG 2127 >gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=2131 Score = 2348 bits (6085), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1332/2145 (63%), Positives = 1558/2145 (73%), Gaps = 63/2145 (2%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 V L+R R +R +L + +EPVAVVGM CRY GGVD+P+ LWELVA GRD VS Sbjct 21 VDYLKRLTADLRRTRRRVAELEGQLSEPVAVVGMACRYAGGVDTPDALWELVAEGRDTVS 80 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 +FP DRGWDV GL+DPDPDA GK YTR G FL FDA FFGI PSEALAMDPQQR++ Sbjct 81 DFPLDRGWDVEGLYDPDPDAKGKMYTRHGSFLQHAGDFDAGFFGIGPSEALAMDPQQRMM 140 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LE+ WEALERAGIDP LRG+ TGVFAGV H YGG+ V G+LE YGL GSTLSV SGR Sbjct 141 LEICWEALERAGIDPFALRGTATGVFAGVIHAGYGGE--VKGELEGYGLTGSTLSVTSGR 198 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 V+YVLGL+GPAVSVDTACSSSLV++HLA QSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 199 VSYVLGLEGPAVSVDTACSSSLVSMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 258 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 RAL+ DGRCK YAGAADGT+++EGAGVLVL RLADARRLGHPVLAL+RG+AVNQDGASNG Sbjct 259 RALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVLALLRGTAVNQDGASNG 318 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RPADR 367 L PNGP+QQRVI AALA+A L ADVD VEGHGTGT LGDPIEAQA+LATYGQ RPADR Sbjct 319 LTAPNGPSQQRVIRAALANAGLTAADVDAVEGHGTGTVLGDPIEAQALLATYGQDRPADR 378 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLP+TLHVDVP+PHVDWSAGAVSLLT+ Sbjct 379 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPRTLHVDVPSPHVDWSAGAVSLLTD 438 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEP--VGAAH-GNDPVAVPWVLSARS 484 PRPW G PRRAGVSSFGISGTNAHVI+E+APA EP V AAH G++P+ VPWV+SARS Sbjct 439 PRPWPDHGGPRRAGVSSFGISGTNAHVIVEQAPA-EPNDVPAAHDGSNPI-VPWVVSARS 496 Query 485 AQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAA 544 AL QA+RLL +GA +V +DVGWSL TR+ F+HRAV++GADR L GL GLAA Sbjct 497 TDALAGQAQRLLDHLGATPDVPAVDVGWSLATTRAAFEHRAVLIGADRAGLSAGLAGLAA 556 Query 545 GVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEW 604 G P + GR + GK FVFPGQG+QWLGMGA L P FA+ E A+ H Sbjct 557 GAPVPGAITGRTRAAGKRVFVFPGQGSQWLGMGAALYERFPAFAQAFDETETAVDAHCRL 616 Query 605 SLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVA 664 L +V+ G+ A L + QPAL+A+ +++A LW S+GV PD VIGHS GEIAAA VA Sbjct 617 PLREVMWGS-DAELLQSTEFAQPALFALEIAMAALWESLGVTPDVVIGHSVGEIAAACVA 675 Query 665 GALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSV 724 GALSL DAA +VA R RL+ +L G M+++ + L + GD + IAAVNG S+ Sbjct 676 GALSLSDAARLVASRGRLMAQLPPGGVMMAVTATEADVAPLLN--GD-VGIAAVNGPQSL 732 Query 725 VLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAF 784 VL+G AV + R A G R R++ V +A HS ++ + + A + G+ R +A Sbjct 733 VLSGSESAVKVVADRLAAGGARVRQLAVSHAFHSPLMEPMMGDFAAVVAGVSAREPRIAL 792 Query 785 FSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEET 844 S +TG+L YW +R+PV+F V+ A G VF+E P + A +++ Sbjct 793 VSNLTGQLAGPDYGTVAYWVDHVRKPVRFVDGVQLAESLGAGVFLEVGPGAAMTAAVDQC 852 Query 845 LVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPT 904 L DR + +V GR + V +AGQ G +DW AAF L RR+ LPT Sbjct 853 LT-TDRAMS---VVSMAKGRPE--VDSLLSAAGQLFATGSDLDWSAAFTGLSARRIPLPT 906 Query 905 YAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLA 964 YAF R+RFWL ++ +GL AEH LL AVV RPDSGGVVLTGR+S A PWL Sbjct 907 YAFVRRRFWLSSDSVGSANIASLGLTEAEHALLGAVVDRPDSGGVVLTGRLSTAAQPWLG 966 Query 965 DHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVG-GVEQS 1023 DHAV VLFPG GFVELALRAGDEVGCSV++ELTL APL +P GV VV + + Sbjct 967 DHAVAGTVLFPGAGFVELALRAGDEVGCSVIEELTLSAPLAVPVGGVVQLQVVVEAADGT 1026 Query 1024 GTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLA 1083 G R V VYS A Q D W LHA+G+L G+ P +LSVWPPVGA A+DVA Y LA Sbjct 1027 GARAVSVYSRAAQTD----WILHAEGLLRDGATTPVTDLSVWPPVGAEAVDVAGAYDGLA 1082 Query 1084 ARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEGE 1141 RGYGYGPAF+GL+A+WRRGAE FA+V LP+ GV GFGIHP +LDAALHA G+ + Sbjct 1083 DRGYGYGPAFQGLRAVWRRGAETFAEVELPQHAGVATGGFGIHPVLLDAALHALGVADER 1142 Query 1142 QQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA- 1200 +T+LPFSWQGV L+A+GA+RVRVRLAP G GAVSV+LAD GLPVLSVR+L+ R VSA Sbjct 1143 IETVLPFSWQGVSLYAAGASRVRVRLAPAGTGAVSVDLADASGLPVLSVRELVTRAVSAD 1202 Query 1201 --AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVH 1258 A + AG LL+++W+P+ L G +G VWE PP G + AVY H Sbjct 1203 QLRAALAARAGSGELLDVVWSPISLPGNGVGQGVTVWEPPP-------GASITAVYTAAH 1255 Query 1259 EVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVD 1318 E L VLQSWL+ DA G VV TRGAV DDV+DLAGAAVWGLVRSAQAEHPGR+VLVD Sbjct 1256 EALGVLQSWLSGDAAGTLVVQTRGAVTLSADDVSDLAGAAVWGLVRSAQAEHPGRIVLVD 1315 Query 1319 TDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVA--AGLTLPSASAGGWRLVAGGG 1376 TDGS+ V +G GEPQLVVR G ++ARL P A L+LP + WRL AG Sbjct 1316 TDGSLDVATVIG----CGEPQLVVRDGIAHSARLKPAGQRALLSLPEPPSV-WRLAAGDA 1370 Query 1377 GTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVG 1436 GTL D+ V P EL GQVRVAV A GVNFRDVLVALGMYPG +LG +GAG+V EVG Sbjct 1371 GTLEDLAVQEYPPAELEAGQVRVAVAAAGVNFRDVLVALGMYPGAAQLGAEGAGIVTEVG 1430 Query 1437 PGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 GVT +AVGD VMG+ GL GSEA VD RLVT VP GWS+ +AA VPV FLTA+YGLSVLA Sbjct 1431 SGVTDVAVGDAVMGIFGLAGSEATVDRRLVTRVPRGWSMAQAAGVPVVFLTAYYGLSVLA 1490 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 + AGQ+VLVHA TGGVGMAAV LAR+WGAEVF TASR KWDTLRAMGFDD HI+DSR+L Sbjct 1491 GLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTLRAMGFDDAHIADSRTL 1550 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE F A G VVLNSLAGEF DASLRLL GGRFIE+GKTD+RD VA H G Sbjct 1551 EFEHKFRAAVGAGGFGVVLNSLAGEFNDASLRLLGRGGRFIEMGKTDLRDPDAVAHAHPG 1610 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 V YRAFDL+EAGPDRIA ML+E++ L A G LA LPVK FDAR A AYRFVSQARHIGK Sbjct 1611 VGYRAFDLMEAGPDRIAEMLAELMTLFAGGALAPLPVKAFDARSAADAYRFVSQARHIGK 1670 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VVLT+PDGP +GLAGGT ++TGGTGMAGSAVA HLV RH V +++LVSR GEQA A Sbjct 1671 VVLTMPDGP---AGLAGGTALITGGTGMAGSAVARHLVERHRVPHVMLVSRGGEQAAGIA 1727 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+A LR+ GA V+VV+CDV DRDA+AALLA + YPL+ VFHAAGV+DDA++ LTP Sbjct 1728 ELAGELRDLGASVSVVACDVGDRDAVAALLARVPSHYPLRSVFHAAGVIDDAMVASLTPA 1787 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 R+D VLRAKVDGAW+LHELT+++ L+AFV FSSMAGIVG P QGNYAAAN+FLD L A+R Sbjct 1788 RIDAVLRAKVDGAWHLHELTKELGLAAFVAFSSMAGIVGAPGQGNYAAANSFLDALAAHR 1847 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 +RGL GLSVAWG+WE+ SAMT HLGE DRARM++AGL+ L+T QAL LD AL DR + Sbjct 1848 HARGLPGLSVAWGMWEEPSAMTHHLGEADRARMSRAGLSALSTRQALDLLDAALLGDRPM 1907 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQR 1976 VV RLDR ALA A LP L SQLA P RR ++ D VS++GL +RL L+PE+RQ Sbjct 1908 VVGTRLDRGALAHHSATLPPLLSQLATRPARRVLEHTDM-VSLTGLRARLDGLSPEQRQA 1966 Query 1977 ELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFD 2036 EL +LV NAA VLG +++ D+NA AF DLGFDSLTAVELRNRLK ATGLTLSPTLIFD Sbjct 1967 ELVELVCGNAATVLGHTTA-DVNADDAFGDLGFDSLTAVELRNRLKIATGLTLSPTLIFD 2025 Query 2037 YPTPATLAEHLDSRLVTASGSDQQSLSDRV---DDITRELVVLLDQPDLSANVKAHLRTR 2093 +PTPA LAEHL + L T S + + DR+ DDITREL LL +P LS +A L R Sbjct 2026 HPTPAALAEHLGTELATGSVAAPATEPDRIARFDDITRELQALLGRPGLSPADRAQLVAR 2085 Query 2094 LQTMLTSLTTE-------------DDDIAAATESQLFAILDEELG 2125 L+ +L + T DDD+A ATESQLFAILD+E+G Sbjct 2086 LEGLLATATGPTPSALPDQPEDAFDDDLATATESQLFAILDDEVG 2130 >gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 [Mycobacterium canettii CIPT 140010059] gi|340004858|emb|CCC44003.1| polyketide synthase PKS8 [Mycobacterium canettii CIPT 140010059] Length=2105 Score = 2328 bits (6033), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1352/2140 (64%), Positives = 1547/2140 (73%), Gaps = 66/2140 (3%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 V L+R R +R DL A+ +EPVAVVGMGCRYPGGVDSPETLWELVA GRDAVS Sbjct 8 VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVS 67 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 +FPADRGWDV GLFDPDPDA GK YTR G FL FDA FFGI PSEALAMDPQQRLL Sbjct 68 DFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLL 127 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LEVSWEALER GIDP LRGS TGVFAGV H YGGQ + G+LE YGL GSTLSVASGR Sbjct 128 LEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGSTLSVASGR 185 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 VAYVLGL+GPAVSVDTACSSSLVALHLAVQSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 186 VAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 245 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 RAL+ DGRCK YAGAADGTA++EGAGVLV+ RL DARRLGHPVLALVRGSAVNQDGASNG Sbjct 246 RALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNG 305 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRP 368 L PNGP+QQRVI AALASARL +VDVVEGHGTGT LGDPIEAQA+LATYGQ + P Sbjct 306 LTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRVE-P 364 Query 369 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEP 428 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+PKTLHVDVPTPHVDWS GAVSLLT+P Sbjct 365 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQP 424 Query 429 RPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVA--VPWVLSARSAQ 486 R W V GRPRRAGVSSFGISGTNAHVILE+AP VE V + A VPWVLSARS Q Sbjct 425 RAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQ 484 Query 487 ALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGV 546 AL QA+RLLA+V A+ ++ P+DVGWSLV TR++F+HRAVVVGADR L+ GL LAAG Sbjct 485 ALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE 544 Query 547 PGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSL 606 GA V GRA++VGKT FVFPGQGAQW+GMGAQL A P+FA L H+ L Sbjct 545 SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPL 604 Query 607 LDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGA 666 VL A L + QPAL+A+ V+LA L + G+ PD +IGHS GEIAAA++AG Sbjct 605 RKVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGV 663 Query 667 LSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVL 726 LSL DAA +VA R RL+ L G MV +A + E++ D N+AAVN SVV+ Sbjct 664 LSLTDAAGLVAARGRLMAELPAGGVMVVVAASE---EEVLPVLVDGANLAAVNAPHSVVV 720 Query 727 AGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFS 786 +G AV+++ G R R+ V +A HS ++ + E GI + S Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 787 TVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLV 846 VTG++ + +YW R+PV+F V+ G FVE P L A +E++L Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSL- 839 Query 847 DCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYA 906 GE + + + R+ V + AG +DW A F GRR+ELPTYA Sbjct 840 -----PLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGS-PGRRIELPTYA 893 Query 907 FARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADH 966 F RQR+WL A D+ GVGL+ A HGLL AVV++PDS VVLTGR+SV WLADH Sbjct 894 FQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADH 953 Query 967 AVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTR 1026 + VVL G FVELALRA D+V C V++ELT+ PLVLP G VV GV + G R Sbjct 954 VIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQR 1013 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V +YS ++DS GW LHA+GVLG +V PAA+LSVWPP+GA +DV YQ A G Sbjct 1014 PVSIYSRNAESDS--GWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELG 1071 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPEGV--PIRGFGIHPAVLDAALHAWGIVEGEQQT 1144 Y YG AF+GL A+WRR +E+FADV +P+ V + GFGIHP VLDAALHA G+V + T Sbjct 1072 YEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAAT 1131 Query 1145 MLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALS 1204 MLPFSWQGV LHA+GA+RVR R+AP G G VSVELAD GLPVLSV+ L++R VS+ LS Sbjct 1132 MLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLS 1191 Query 1205 RSTAGD----RGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 + A RGLLE+ W PV L DI D VVWEL ++ D + VY H V Sbjct 1192 AAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL------ESFQDGVGPVYSATHRV 1245 Query 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 L LQSWLA + G VV+T+G+VG D T+LAGAAVWGLVRSAQAEHPGRV+LVD+D Sbjct 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLVDSD 1302 Query 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGWRLVAGGGGT 1378 GS+ V D +G GE QL++R G YAARLA + L LP ++G WRLVAGG GT Sbjct 1303 GSMDVGDVIG----CGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSG-WRLVAGGAGT 1357 Query 1379 LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 L D+ +A ELA GQVR+ V A+GVNFRDVLVALGMYPG ELG +GAGVV EVGPG Sbjct 1358 LEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGMYPGAAELGAEGAGVVTEVGPG 1417 Query 1439 VTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEV 1498 VTGLAVGD VMGLLG+ GSEAVVDARLV +P W L +AA VPV FLTA+Y L VLA+V Sbjct 1418 VTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQV 1477 Query 1499 AAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEF 1558 G+ VLVHA GGVGMAAV LAR WG EVF TASR KWDTL MG D+ H++DSR+L F Sbjct 1478 QPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAF 1537 Query 1559 EEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVR 1618 EE F TEG GVDVVLNSLAGEFTDASLRLLP GGRFIE+GKTD+RD Q VA+ H GV Sbjct 1538 EETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTDVRDAQVVAQDHPGVA 1597 Query 1619 YRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVV 1678 YRAFDL+EAGP RIA ML+E+V L L RLPVK++D R A AYRF+SQARH+GKVV Sbjct 1598 YRAFDLMEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVRHAREAYRFLSQARHVGKVV 1657 Query 1679 LTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEV 1738 LT+PD A GTV++TGGTGMAGSAVA HLV R+GV +VL SR+GE + A + Sbjct 1658 LTMPD------AWAAGTVLITGGTGMAGSAVARHLVSRYGVRQVVLASRAGEHTESVAAL 1711 Query 1739 AALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRV 1798 L GA+V VVSCDVADRDA+A L+A + L VFHAAGVLDDAVITGLTPDRV Sbjct 1712 VDELGSAGARVQVVSCDVADRDAVAGLVAS---QPDLTAVFHAAGVLDDAVITGLTPDRV 1768 Query 1799 DTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRS 1858 D VLRAKVDGAWNLHELT +D+SAFV+FSSMAGIVG P Q NYAAANAFLDGL AYRRS Sbjct 1769 DKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQANYAAANAFLDGLAAYRRS 1828 Query 1859 RGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVV 1918 RGLA LSVAWGLWEQASAMT HLGERDR RM++ GLAPL T QA+GFLD AL ADR VVV Sbjct 1829 RGLAALSVAWGLWEQASAMTEHLGERDRVRMSRVGLAPLPTNQAMGFLDAALLADRPVVV 1888 Query 1919 AARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQREL 1978 AAR A AGA LPALFSQL AGP RR ID AD VS SGL SRLH LTPE+R REL Sbjct 1889 AAR--LDRAALAGAELPALFSQLVAGPIRRIIDGADE-VSGSGLASRLHGLTPEQRHREL 1945 Query 1979 TDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYP 2038 T+LV SNAA VLG S + +I+AHKAFQDLGFDSLTAVELRNRLKTATGLTL PTLIFDYP Sbjct 1946 TELVCSNAAIVLGHSGT-EIDAHKAFQDLGFDSLTAVELRNRLKTATGLTLPPTLIFDYP 2004 Query 2039 TPATLAEHLDSRLVTASG--SDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQT 2096 T A LAEHLD +L A DQ + S R +++T EL LLDQP+ + + K L RLQ Sbjct 2005 TAAELAEHLDIQLANAPAVTVDQPNPSTRFNEVTGELQALLDQPNWNPDDKTRLIKRLQA 2064 Query 2097 MLT-----------SLTTEDDDIAAATESQLFAILDEELG 2125 +LT S T +D+DI ATESQLFAILD+ELG Sbjct 2065 ILTDCTAPPASSGPSTTHDDEDITTATESQLFAILDDELG 2104 >gi|308380139|ref|ZP_07669124.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu011] gi|308362416|gb|EFP51267.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu011] Length=1192 Score = 2324 bits (6023), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1173/1173 (100%), Positives = 1173/1173 (100%), Gaps = 0/1173 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRG 1173 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRG Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRG 1173 >gi|308376783|ref|ZP_07668349.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu008] gi|308349971|gb|EFP38822.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu008] Length=1192 Score = 2321 bits (6016), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1172/1173 (99%), Positives = 1172/1173 (99%), Gaps = 0/1173 (0%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV Sbjct 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA Sbjct 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Sbjct 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV Sbjct 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY Sbjct 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 Query 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG Sbjct 361 GQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG 420 Query 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL Sbjct 421 AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVL 480 Query 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT Sbjct 481 SARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLT 540 Query 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE Sbjct 541 GLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA Sbjct 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAA NG Sbjct 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAGNG 720 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS Sbjct 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG Sbjct 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV Sbjct 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA Sbjct 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV Sbjct 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGV 1020 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ Sbjct 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG Sbjct 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRGFGIHPAVLDAALHAWGIVEG 1140 Query 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRG 1173 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRG Sbjct 1141 EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRG 1173 >gi|183980137|ref|YP_001848428.1| polyketide synthase PKS [Mycobacterium marinum M] gi|183173463|gb|ACC38573.1| polyketide synthase PKS [Mycobacterium marinum M] Length=2197 Score = 2319 bits (6010), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1314/2137 (62%), Positives = 1559/2137 (73%), Gaps = 74/2137 (3%) Query 1 MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELV 60 M+ +L +AL+R + + + + R+ R PVA+VG+GCRYPGGV+S LW++V Sbjct 12 MDPEHNNLFEALKRVAVELNQTRAQLREHEERADVPVAIVGVGCRYPGGVESAGGLWDVV 71 Query 61 AHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALA 120 GRD +S FP DRGWDV G+FDPDPDA+GK+Y R GGFL FDA FFGI PSEAL Sbjct 72 VGGRDVISGFPVDRGWDVEGVFDPDPDALGKTYCRLGGFLDGADRFDAGFFGIGPSEALV 131 Query 121 MDPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGS 180 MDPQQRLLLE SWEALE AGIDP++LRGS TGVF G+ YG GRV GDLE YGL + Sbjct 132 MDPQQRLLLECSWEALEDAGIDPVSLRGSVTGVFTGLMSSDYGA-GRVSGDLEGYGLTSA 190 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 SVASGRVAY+LGL+GPAVSVDTACSSSLVALHLA SLR GECD+AL GGVTVMATPA Sbjct 191 AASVASGRVAYLLGLEGPAVSVDTACSSSLVALHLAASSLRSGECDVALAGGVTVMATPA 250 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 F+ FSRQR L+ADGRCKA+AGAADGT F+EGAGV+VL RL++ARR G VL ++ GSAV Sbjct 251 TFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVVVLMRLSEARRRGLAVLGVIAGSAV 310 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGASNGL PNGPAQQRVI AALA+A L ADVDVVEGHGTGTTLGDPIEAQA+LATY Sbjct 311 NQDGASNGLTAPNGPAQQRVIEAALANAGLTAADVDVVEGHGTGTTLGDPIEAQALLATY 370 Query 361 GQ-RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSA 419 GQ RPADRPLWLGSIKSN+GHT AAAG+AGVIKMVQAMRH ++P TLHVDVP+PHVDWS+ Sbjct 371 GQARPADRPLWLGSIKSNMGHTQAAAGIAGVIKMVQAMRHELMPATLHVDVPSPHVDWSS 430 Query 420 GAVSLLTEPRPW-HVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPW 478 GAVSLLT+PRPW V GRPRRAGVSSFGISGTNAHVI+E+ E V A P ++PW Sbjct 431 GAVSLLTQPRPWPAVDGRPRRAGVSSFGISGTNAHVIVEQV-CPEVVAEAVDVSPDSLPW 489 Query 479 VLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEG 538 V+S +S A+ QA+RLLA V ADE + LDVG+SL R+ F++RAVV+G DR QL+ G Sbjct 490 VVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVGFSLAR-RTAFEYRAVVLGEDRQQLISG 548 Query 539 LTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERAL 598 LT LAAG PG V+ GRA TV KT VFPGQG+QW GMG +L A +PVFAEH+ C AL Sbjct 549 LTELAAGQPGPTVLNGRAATVSKTVMVFPGQGSQWPGMGRELLAASPVFAEHMRLCAEAL 608 Query 599 REHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEI 658 E V+WSLLDV+ G GAP LDRVDVVQP LWA+MVSLA+LWRSVGVVPDAVIGHSQGEI Sbjct 609 GEFVDWSLLDVVNGVAGAPTLDRVDVVQPVLWAMMVSLAQLWRSVGVVPDAVIGHSQGEI 668 Query 659 AAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAV 718 AAA VAGALSLRD AAVVALRSR LV L G GGMV++ACG + +L + +GDRL++AAV Sbjct 669 AAACVAGALSLRDGAAVVALRSRALVDLAGTGGMVAIACGVERVRELLADYGDRLSLAAV 728 Query 719 NGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPR 778 NGV++VV++GE A+ L RCEAEG+RARRI+VDYASHSAQV++I L+ AL G+ PR Sbjct 729 NGVAAVVVSGEAKALRGLTGRCEAEGMRARRIEVDYASHSAQVESIGSSLVEALAGVRPR 788 Query 779 TSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLI 838 +S + F STVTG +D A + A+YWYR+IRQ V+F+RAVR + G R FVE+SPHPVL+ Sbjct 789 SSDIEFVSTVTGASVDGASLGADYWYRNIRQTVRFDRAVRYCHEQGCRTFVEASPHPVLL 848 Query 839 AGIEETLVD-CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGG 897 AGIEE+L + R + IVIPTLGR++GGV RFW+S QA +AGVGVDW A FA GG Sbjct 849 AGIEESLAEGIGRPDSAGVIVIPTLGRNEGGVERFWMSLSQAWLAGVGVDWSAVFAGSGG 908 Query 898 RRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISV 957 R+V LPTYAFAR+RFWLDG A D+G GLV A H LL AVV++PD+G VVLTGR+S+ Sbjct 909 RQVGLPTYAFARRRFWLDG-SASAADVGEAGLVAAGHALLGAVVEQPDTGAVVLTGRLSL 967 Query 958 VAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPA-DGVRVQVV 1016 PWLADH VG VLFPGTGFVELA+RAGDEVGC V++ELTL PLVL A V+VQVV Sbjct 968 ARQPWLADHLVGGAVLFPGTGFVELAIRAGDEVGCGVVEELTLATPLVLNAGTAVQVQVV 1027 Query 1017 VGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQG----VLGVGSVQPAAELSVWPPVGARA 1072 VG QSG R V +YS A Q D W LHAQG + +AELS WPP GA A Sbjct 1028 VGSAGQSGQRLVSMYSRADQPDQH--WVLHAQGSVAPAAVQPAAAASAELSTWPPAGAEA 1085 Query 1073 MDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDA 1130 +D+ Y+ LA RGYGYGPAF+GL+A+WRRG +VFA+V LP +G+ + GIHPA+LDA Sbjct 1086 VDIGGLYERLARRGYGYGPAFQGLRAVWRRGRDVFAEVGLPNDDGLDLTDVGIHPALLDA 1145 Query 1131 ALHAWGIVEG----EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLP 1186 ALHAW V G + T+LPFSWQ + LH SGA+R+RVR+AP G AVSVELAD GLP Sbjct 1146 ALHAWLCVGGFGGDGEATVLPFSWQHLSLHGSGASRLRVRIAPAGPSAVSVELADGAGLP 1205 Query 1187 VLSVRQLMVRPVSAAAL--SRSTAGD---RGLLEMIWTPVPLEGGDIGDD---------- 1231 VLSV L RPV AA L + S GD R LL ++WTP+ E + D Sbjct 1206 VLSVGSLTTRPVGAAQLQAAMSAGGDGTGRELLNVVWTPITFERDSVQRDGERRVVSWDD 1265 Query 1232 ----------------AVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGL 1275 AVVW+ GA++ V+ VY H VLEVLQ WLA D + Sbjct 1266 FLAGRCAAARDLDRDVAVVWQW-ESGGAES---VVNTVYTATHRVLEVLQRWLADDLPAV 1321 Query 1276 GVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARS 1335 VV TRGA+G + +TDLAGAAVWGLVRSAQ EHPGR+VL+DTD S+A+ +G Sbjct 1322 LVVCTRGAMGLAGEAITDLAGAAVWGLVRSAQTEHPGRIVLIDTDTSMALPTVIGV---- 1377 Query 1336 GEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVE--LA 1393 GEPQLVVR G VYAARLA A L P A GW+L A GGGT DVV+ P + LA Sbjct 1378 GEPQLVVRAGDVYAARLARGRAALRTPDAGQ-GWQLAATGGGTFDDVVLEPCPRSDEPLA 1436 Query 1394 TGQVRVAVGAVGVNFRDVLVALGMYPGGG-ELGVDGAGVVVEVGPGVTGLAVGDRVMGLL 1452 GQVRVA+ A+GVNFRDVLV LG+YPG LG +GAGVVVEVGPGV+GL GDRV+GL+ Sbjct 1437 VGQVRVALAALGVNFRDVLVVLGLYPGNKPTLGGEGAGVVVEVGPGVSGLEPGDRVLGLM 1496 Query 1453 GLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGG 1512 SE VVD RL+ +PAGWS EAA+ P+ FLTAFYGLS LA + G+ VLVHA TGG Sbjct 1497 S-GRSECVVDQRLLVPIPAGWSFAEAASAPIVFLTAFYGLSDLAGLRRGESVLVHAATGG 1555 Query 1513 VGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVD 1572 VGMAA+ LAR WGA VFVTASR KWDTLRAMGFDD I+DSR+LEFEE F AT G G+D Sbjct 1556 VGMAAIQLARLWGARVFVTASRGKWDTLRAMGFDDDQIADSRTLEFEEKFSAATGGRGID 1615 Query 1573 VVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLV-EAGPDR 1631 VVLN+LAGEFTDASLRLL GRFIE+GKTDIRD Q VA+ H GV YRAFDL E P R Sbjct 1616 VVLNALAGEFTDASLRLLAERGRFIEMGKTDIRDAQEVAQEHPGVSYRAFDLANEVAPQR 1675 Query 1632 IAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGL 1691 + ML+E++ L AAG L RLPVKT+D RCAP AY+FVSQARHIGKVVL+ P + L Sbjct 1676 LGQMLAELMTLFAAGKLHRLPVKTWDVRCAPQAYQFVSQARHIGKVVLSAPTEL--RDAL 1733 Query 1692 AGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAV 1751 A GTV++TGGTG+ GS +A HLV +GV NLVLVSR GEQ AE+ L + GA+V V Sbjct 1734 AAGTVLITGGTGLVGSVLARHLVSAYGVRNLVLVSRMGEQGAGVAELVDELSDAGARVLV 1793 Query 1752 VSCDVADRDALAALLAGLDPRYP-LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAW 1810 +CDVAD+ A+ L+AG YP L GV HAAGVLDDAVIT +TPD+VD+VLRAKVDGAW Sbjct 1794 AACDVADQSAVEKLIAGWGREYPALTGVIHAAGVLDDAVITSMTPDQVDSVLRAKVDGAW 1853 Query 1811 NLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGL 1870 NLH T + LS FV+ SS+AG+VG P QGNYAAANAFLD LV RR+ GLAG+S+ WGL Sbjct 1854 NLHHATRGLGLSMFVLCSSIAGVVGAPGQGNYAAANAFLDALVTDRRAHGLAGVSLGWGL 1913 Query 1871 WEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGA 1930 WEQAS MT+HL D +R+++ G A ++ +QAL D AL D+ V+AARLDR AL Sbjct 1914 WEQASGMTKHLRGSDVSRLSRGGFAAISAQQALDLFDAALIVDQPTVLAARLDRRALENP 1973 Query 1931 --GAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAA 1988 A LP LFS L P RR +D T ++ LV+RL+ + P+ + LT++V + A Sbjct 1974 ALNADLPTLFSDLITRPMRRNVDNDGTPTELA-LVNRLNMMNPDEQHDLLTEVVCTQAVM 2032 Query 1989 VLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLD 2048 VLGR ++ DI+ + F DLGFDSLTA+ELRNRLKT TGLTL PTLIFD+ P+ LA+HL Sbjct 2033 VLGRLNAADIDPNATFSDLGFDSLTAIELRNRLKTVTGLTLPPTLIFDHRAPSALAQHLG 2092 Query 2049 SRLVTASGSDQQSL---SDRVDDITRELVVLLDQPDL 2082 +L + + +D D+ R ++ + DL Sbjct 2093 QQLCVTHQHESHNAMAPADSEDEKLRSILSAISVADL 2129 >gi|183983097|ref|YP_001851388.1| polyketide synthase PKS [Mycobacterium marinum M] gi|183176423|gb|ACC41533.1| polyketide synthase PKS [Mycobacterium marinum M] Length=2666 Score = 2265 bits (5869), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1293/2105 (62%), Positives = 1515/2105 (72%), Gaps = 69/2105 (3%) Query 2 NSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVA 61 ++ + L+ ++R + L+ + R R TEPVA+VGMGCR+PGGVDS ++LW++V Sbjct 7 DTKHQKLLHYVKRVAGELNDLRAQLRTSEYRATEPVAIVGMGCRFPGGVDSADSLWDMVV 66 Query 62 HGRDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAM 121 RD +S+FP DRGWD LFDPDPDA+G++Y GGFL D AGFDA FFGIAP EALAM Sbjct 67 SARDVISDFPGDRGWDAGRLFDPDPDALGRTYCAVGGFLEDAAGFDAGFFGIAPREALAM 126 Query 122 DPQQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYG-GQGRVPGDLERYGLRGS 180 DPQQR+LLEVSWEALE AGIDP +LRG+ TGVF G+F +YG G G D+ YGL GS Sbjct 127 DPQQRVLLEVSWEALEDAGIDPRSLRGTATGVFTGIFAQAYGIGAGL---DVGEYGLTGS 183 Query 181 TLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA 240 T SVASGRVAYVLGL+GPAVSVDTACSSSLVA+H AVQSLRLGECDLAL GGVTVMATP+ Sbjct 184 TSSVASGRVAYVLGLEGPAVSVDTACSSSLVAVHQAVQSLRLGECDLALAGGVTVMATPS 243 Query 241 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAV 300 +F+ FSRQR L+ DGRCKA+A AADG + EGAGVLVL RL+DARR G VL +VRGSAV Sbjct 244 VFVGFSRQRGLAPDGRCKAFAEAADGVGWGEGAGVLVLQRLSDARRQGRVVLGVVRGSAV 303 Query 301 NQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATY 360 NQDGAS+GL PNGPAQQRVI AALA A LG ADVDVVE HGTGT LGDPIEAQA+LA Y Sbjct 304 NQDGASHGLTAPNGPAQQRVIRAALAGAGLGPADVDVVEAHGTGTRLGDPIEAQALLAVY 363 Query 361 GQ-RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSA 419 GQ R RPLW+GSIKSN+GH AAAGVAGVIKMVQAMRHG+LP+TLHVD P+ VDWSA Sbjct 364 GQDREPGRPLWVGSIKSNMGHAQAAAGVAGVIKMVQAMRHGLLPETLHVDEPSGQVDWSA 423 Query 420 GAVSLLTEPRPW-HVPGRPRRAGVSSFGISGTNAHVILEEA-PAVEPVGAAHGN------ 471 GAV +L+ R W VPGRPRRAGVSSFGISGTNAHVI+E+A P V G G Sbjct 424 GAVEVLSRARSWLGVPGRPRRAGVSSFGISGTNAHVIVEQALPEVAESGGVSGVCGQGVG 483 Query 472 ------DPVAVPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRA 525 VPWVLSA+S QAL QA RLL VG D+ + P+DVG SL R +F+HRA Sbjct 484 SVESVVRASVVPWVLSAQSRQALVAQASRLLGRVGGDDGLDPVDVGLSLAQ-RCVFEHRA 542 Query 526 VVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAP 585 VVVG DR L+ GLTGLA G PGA VV G+A VGKT VFPGQGAQW GMG QL +P Sbjct 543 VVVGRDREALLAGLTGLARGEPGAGVVVGQAAAVGKTVLVFPGQGAQWTGMGRQLFDESP 602 Query 586 VFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGV 645 VFAE + RC+ AL E V WSLLDV+ G GAPGLDRVDVVQP WA+MVSLAELWRSVGV Sbjct 603 VFAERMRRCDEALAEFVSWSLLDVVTGVAGAPGLDRVDVVQPLSWAIMVSLAELWRSVGV 662 Query 646 VPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKL 705 PDAVIGHSQGEIAAA VAGALSLRD AAVVALRSRLLV L GAG M SLACG +AE+L Sbjct 663 TPDAVIGHSQGEIAAACVAGALSLRDGAAVVALRSRLLVDLAGAGAMASLACGVARAEQL 722 Query 706 ASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIR 765 + +GDRL++AA+NGVS+VV++G DAV ELM E +G+RARRI+VDYASHSAQVDAI Sbjct 723 LAGFGDRLDLAAINGVSAVVISGRVDAVLELMDLAETQGVRARRIEVDYASHSAQVDAIA 782 Query 766 EELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGY 825 L+ AL GIEPR S+ +FFSTVTG LMDTA ++ YW+RSIRQ VQF AVR A GY Sbjct 783 GPLMEALAGIEPRPSSTSFFSTVTGGLMDTAELDGGYWFRSIRQTVQFAEAVRAAGAQGY 842 Query 826 RVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVG 885 VFVE+S HP+L+ IEETL + A +V+PTLGRDDGG+GRFW+SAGQAHVAGVG Sbjct 843 GVFVEASAHPLLLNAIEETLAEETGDAAKNVVVVPTLGRDDGGLGRFWMSAGQAHVAGVG 902 Query 886 VDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPD 945 +DWRA +A G R VELPTYAF RQRFWL D G+GL A HGLL A V+ PD Sbjct 903 MDWRAVYAGWGARLVELPTYAFQRQRFWLPPAPTGSVDPAGLGLGEAGHGLLCAAVEHPD 962 Query 946 SGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLV 1005 S V+LTGR+S+ A PWLADHAV V+LFPGTGF+EL +RAGD VGC++++ELT+ APLV Sbjct 963 SREVILTGRLSLSAQPWLADHAVLGVMLFPGTGFLELVIRAGDVVGCTLVRELTMVAPLV 1022 Query 1006 LPADGVRVQVVVGGVE-QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSV 1064 L D VV + G+R+V VYS + DS GW L+AQGVL V VQP AE+S Sbjct 1023 LSHDVPVQVQVVVAPDGGDGSRSVTVYSHTDRPDS--GWLLNAQGVLDVDVVQPPAEVSE 1080 Query 1065 WPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRG--FG 1122 WPP GA ++++D Y+ LAARG+ YG AFRG ALWRR E+FA+V LPE V + FG Sbjct 1081 WPPAGAVRVEISDAYEQLAARGFEYGQAFRGCTALWRRDQELFAEVALPEQVSAQAGRFG 1140 Query 1123 IHPAVLDAALHA--WGIVE------GEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGA 1174 IHPA+LDAALHA +G ++ G + +LP+SWQ V L+A GA R+RVR+ P G Sbjct 1141 IHPALLDAALHAGLYGALDFGGSRAGNAEAVLPYSWQRVSLYAGGAERLRVRITPSASGT 1200 Query 1175 VSVELADPQGLPVLSVRQLMVRPVSAAALSRSTAG-----DRGLLEMIWTPVPLEGGDIG 1229 VS+ELAD G PVLS L VRPV A L + + D+GLLE+ W+P+ +E G Sbjct 1201 VSIELADSAGGPVLSAGSLAVRPVGTAELRAALSAAARETDQGLLELAWSPITVESTSGG 1260 Query 1230 DDAVVWELP-------PHAGAQ----------AGGDVLAAVYRGVHEVLEVLQSWLASDA 1272 VV E HA Q AGG VL YR H LEVLQ WLA D Sbjct 1261 HRPVVLEWADYVAADDDHAAGQADVVLWRCEPAGGRVLDQAYRATHAALEVLQHWLARDR 1320 Query 1273 TGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFG 1332 + V+ T GAVG + D+TDLAGAAVWGLVRSAQ EH GR+VL+DTD AV D G Sbjct 1321 SATLVIATHGAVGSAEHDITDLAGAAVWGLVRSAQTEHSGRIVLIDTD--TAVVDLAGLL 1378 Query 1333 ARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVA--PVAPV 1390 A + EPQL+VR GRV+AARLA V L LP+ WRL AGG GTLA VV+ P A Sbjct 1379 A-TKEPQLMVRAGRVHAARLAAVEETLVLPTHQQ--WRLAAGGEGTLAGVVMEPNPQAQA 1435 Query 1391 ELATGQVRVAVGAVGVNFRDVLVALGMYPGGG-ELGVDGAGVVVEVGPGVTGLAVGDRVM 1449 L GQVRVAV A GVNFRDVLV LGMYPG LG +GAGVVVEVG V L+VGD+VM Sbjct 1436 PLGPGQVRVAVAAAGVNFRDVLVVLGMYPGQAPPLGGEGAGVVVEVGHHVRRLSVGDQVM 1495 Query 1450 GLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAG 1509 GL+G+ G EAVVD RL+ +P+GWSL +AA VPVAFLTA+YGLS LA V +G+ VLVHA Sbjct 1496 GLVGVAGPEAVVDQRLLVKLPSGWSLAQAAGVPVAFLTAWYGLSDLAGVRSGESVLVHAA 1555 Query 1510 TGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGS 1569 TGGVGMAAV LAR+WG EVFVTASR KWD LR MGFDD HI DSR+++F + FL T+G Sbjct 1556 TGGVGMAAVQLARHWGLEVFVTASRGKWDILRRMGFDDDHIGDSRTVDFADKFLAVTDGR 1615 Query 1570 GVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGP 1629 GVDVVLNSLAGEF DASLRLL GGRFIE+GKTDIRD T+A+ H V YRAFDL+E+GP Sbjct 1616 GVDVVLNSLAGEFIDASLRLLARGGRFIEMGKTDIRDPHTIAQNHPRVTYRAFDLLESGP 1675 Query 1630 DRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQS 1689 RI AML ++ L A L LP+KT+D RC PAAYRFVSQARHIGKV+LT+P Sbjct 1676 ARIQAMLGALLELFQARALHPLPIKTWDVRCTPAAYRFVSQARHIGKVILTMPTLL--PD 1733 Query 1690 GLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQV 1749 LA GTV++TGGTGM +A+A HLV HGV +LVLVSR G+ A A+++ L GA V Sbjct 1734 ALAAGTVLITGGTGMVAAALARHLVSSHGVRHLVLVSRRGDAAAGASKLVDELTAAGATV 1793 Query 1750 AVVSCDVADRDALAALLAGLDPRY-PLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDG 1808 VV+CDVAD A++ L+ L + PL V HAAG LDDA+IT LTP RVD VLRAKVDG Sbjct 1794 RVVACDVADPAAVSRLMNQLPEQCPPLSAVIHAAGTLDDALITSLTPQRVDAVLRAKVDG 1853 Query 1809 AWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAW 1868 AWNLHE T D+ LSAFV+ SS+A +G P Q NYAA NAFLD L A+R + GLAG+S+AW Sbjct 1854 AWNLHEATRDLGLSAFVLCSSIAATLGAPGQANYAAGNAFLDALAAHRHATGLAGISLAW 1913 Query 1869 GLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALA 1928 GLWEQ+S MT HL RD RMT+ G+ ++ EQA+ D AL D VV +RLD AALA Sbjct 1914 GLWEQSSTMTAHLRGRDVDRMTRIGMRAISAEQAIELFDAALVLDHPTVVTSRLDEAALA 1973 Query 1929 GA--GAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPERRQRELTDLVISNA 1986 + LP LF+ L P RRR+D DT + S L RL+ L PER++ ++V A Sbjct 1974 NPTISSQLPPLFNDLIRRPVRRRVD-NDTMAAKSILAQRLNDLAPERQRVAFIEMVCEQA 2032 Query 1987 AAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEH 2046 AAVLGR + D++ F+DLG DSLT +ELRNRLK +GL L PTLI D+PTP LA + Sbjct 2033 AAVLGRPNGDDVDPEHTFRDLGLDSLTDLELRNRLKIISGLALPPTLIVDHPTPQLLAGY 2092 Query 2047 LDSRL 2051 L RL Sbjct 2093 LSQRL 2097 >gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Mycobacterium marinum M] gi|183176352|gb|ACC41462.1| polyketide synthase, Pks12 [Mycobacterium marinum M] Length=4187 Score = 2259 bits (5854), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1264/2077 (61%), Positives = 1509/2077 (73%), Gaps = 39/2077 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA GRD +S+ Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVAEGRDVMSD 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+A LFDPDPD KSY GGF+ VA FD FFGIAPSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLADLFDPDPDTPHKSYASTGGFVDGVADFDPGFFGIAPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALER+GIDP LRGS TGVFAG+ YG ++E Y L G T SVASGRV Sbjct 130 ELSWEALERSGIDPTGLRGSATGVFAGLIVQGYG---MFAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGR KAYAGAADG ++EG +LV+ RL+DA+RLGHPVLALVRGSAVNQDGASNGL Sbjct 247 GLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR-----P 364 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGSAGA 366 Query 365 ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSL 424 A + LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH VLP TLHVDVP+PHVDWSAGAV L Sbjct 367 AGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWSAGAVEL 426 Query 425 LTEPRPWHVPG---RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 LTE +PW R RRAGVSSFGISGTNAHVI+E AP VE G++ G PV VPWV+S Sbjct 427 LTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPV-VPWVVS 485 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A V + + + DVGWSL RS F+HRAVV+G DR L+ GL Sbjct 486 AKSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGVDRDGLLAGLDE 544 Query 542 LAAG-VPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 LA GA V+ G A GKT FVFPGQG+QW+GMG +L TAPVFA HI C +A E Sbjct 545 LAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTAPVFARHIESCGQAFAE 604 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 V+WSLLDVLRGA GAPGLDRVDVVQP L+AVMVSLAELW+SVGV PDAVIGHSQGEIAA Sbjct 605 FVDWSLLDVLRGAAGAPGLDRVDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEIAA 664 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAA VV LRS+LLV L G GGMVS+ACG+ QA +L +GDR++IAA+NG Sbjct 665 AYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAING 724 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 S+VV++GE A+ EL+ +C +R RRIDVDYASHS +V+AI +L L GIEP +S Sbjct 725 PSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPLSS 784 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 AFFS+VTG +DTA ++AEYWYR+IRQ VQF++AVR+A GYR F+ESSPHP LIAG Sbjct 785 RTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAVRSACGHGYRTFIESSPHPALIAG 844 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IE+T +C + +PIV+PTLGR+DGG+ RF SA A VAGV VDWR G V Sbjct 845 IEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAAAAFVAGVNVDWRGPLD--GAGLV 902 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAF ++RFWL G G V D G+GL H LL AVV+ P+SGGVVLTGR+++ A Sbjct 903 ELPTYAFEKRRFWLSGEG-VSVDASGLGLSAGGHALLGAVVELPESGGVVLTGRLALGAH 961 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGG 1019 WLADHAV VV+FPGTGFVELA+RAGDEVGCSV+ ELTL+ PLVLPA G V VQVVVG Sbjct 962 GWLADHAVSGVVVFPGTGFVELAIRAGDEVGCSVVNELTLRTPLVLPASGSVAVQVVVGA 1021 Query 1020 VEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGY 1079 S R+V +YS D+ W HA+G LG S QPAA+LS WPP GA A+DVADGY Sbjct 1022 AADSAERSVSIYSRT-DTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAIAVDVADGY 1080 Query 1080 QVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGV-PIRGFGIHPAVLDAALHAWGIV 1138 + L ARGYGYGPAFRGL A+W RG E+FA+V LPE GFG+HPA+LDAALH I Sbjct 1081 ERLDARGYGYGPAFRGLTAMWARGEELFAEVRLPEAAGSTSGFGVHPALLDAALHTAVIA 1140 Query 1139 EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPV 1198 + + +LPFSWQGV LHA+GAA VRVR+APVG +VSVELAD GLPVLSV+ ++ RPV Sbjct 1141 NPDAELVLPFSWQGVSLHAAGAASVRVRIAPVGPSSVSVELADDLGLPVLSVKAMVARPV 1200 Query 1199 SAAALSR--STAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRG 1256 S + S +G L E++WTP+ + D A +EL A+ GD L+ Y+ Sbjct 1201 SEQQMRAVVSASGPDRLFEVVWTPMTVAATDA---APAYELFESVAAE--GDPLSGTYQR 1255 Query 1257 VHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVL 1316 H+ L +QSWL +G+ VV TRGA+ +DVTDLAGAAVWGLVRSAQ E+PGR+VL Sbjct 1256 THQALAAVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPGRLVL 1315 Query 1317 VDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGLTLPSASAGGWRLVAG 1374 VD+D + AV GEPQ+V+R G+ Y AR+ + A G+ +P G WRL Sbjct 1316 VDSD-AAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILVPPVD-GPWRLGLS 1373 Query 1375 GGGTLADVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVV 1432 GT ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ +G +GAGVV Sbjct 1374 SAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALIGGEGAGVV 1433 Query 1433 VEVGPGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFY 1490 VE+GP VT AVGD V G GS +V D RL+ PA WS EAAA+ F TA+Y Sbjct 1434 VEIGPEVTEFAVGDAVYGFFP-DGSGTLVAGDVRLLLPKPADWSYAEAAAISAVFTTAYY 1492 Query 1491 GLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHI 1550 LA V GQ+VLVHA TGGVGMAAV LAR+ G EV+ TAS+ KWD LRAMGFD+ HI Sbjct 1493 AFVHLANVQPGQRVLVHAATGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHI 1552 Query 1551 SDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTV 1610 SDSRSLEFEE F T G GVDVVL+SLAGEF DASLRLL GG F+E+GKTDIRD + Sbjct 1553 SDSRSLEFEEKFREVTGGRGVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGVI 1612 Query 1611 AERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQ 1670 A+ + GVRYRAFDL E G R+ + ++ GL AGVL LPV FD R APAA R++SQ Sbjct 1613 AQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVRRAPAALRYLSQ 1672 Query 1671 ARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGE 1730 ARHIGKVV+T+P GG L GGTV++TGGTGMAGSA+A HLV HGVA+LVL+SR G Sbjct 1673 ARHIGKVVMTMPADQGG--ALGGGTVLITGGTGMAGSALARHLVAHHGVAHLVLISRRGP 1730 Query 1731 QADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVI 1790 A A E+ A L GAQV VV+CD ADR ALA ++A + + PL V HA GVLDDAVI Sbjct 1731 AAPGATELVAELSAAGAQVEVVACDAADRPALAKVIAEIPAQRPLSAVVHAGGVLDDAVI 1790 Query 1791 TGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLD 1850 + LTP+RVDTVLRAKVD AWNLHELT D+DLSAFV+FSSMAG+VG+ Q NYAAAN F+D Sbjct 1791 SSLTPERVDTVLRAKVDAAWNLHELTRDLDLSAFVMFSSMAGVVGSSGQANYAAANTFVD 1850 Query 1851 GLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTAL 1910 GL A+RR+ GL +S+ WGLW+QAS MT + DRAR+ + G+ L++++A+ DTAL Sbjct 1851 GLAAHRRAHGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDTAL 1910 Query 1911 QADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHAL 1969 ++A + AR+D AAL A+P +FS L + PTRR++ DA A S S L RLH L Sbjct 1911 IVNQAFLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQVDDALAAAKSKSALAHRLHGL 1970 Query 1970 TPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTL 2029 + + DLV S+ A VLG + I+ KAFQ+LGFDSLTAVE+RNR+KT TGL+L Sbjct 1971 PEPEQHAVVLDLVRSHIATVLGTITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVTGLSL 2030 Query 2030 SPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRV 2066 SPTLIFDYPTP LA ++ + L A + + + RV Sbjct 2031 SPTLIFDYPTPNGLANYIRAELAGAPQEVKHTPAVRV 2067 Score = 2013 bits (5216), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1172/2103 (56%), Positives = 1424/2103 (68%), Gaps = 84/2103 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + +P+A+VGM CRYPGG++SP+ LW+++ Sbjct 2040 TPNGLANYIRAELAGAPQEVKHTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR 2099 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +S+FPADRGWD+AGLF+PDPD G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2100 RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFDPAFFGVGPSEALAMDP 2159 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+ LE+SWEALERAGI+P LRGS TGVFAGV YG P +E + L G S Sbjct 2160 QQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2217 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GGVT+ ATP +F+ Sbjct 2218 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPDIFV 2277 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LSADGRCKA+AGAADGT F+EG G+LV+ RL+DA+RLGHPVLALVRGSAVNQD Sbjct 2278 EFSRWRGLSADGRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQD 2337 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2338 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2397 Query 364 -----PADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWS 418 A + LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH VLP TLHVDVP+PHVDWS Sbjct 2398 RGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWS 2457 Query 419 AGAVSLLTEPRPWHVPG---RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVA 475 AGAV LLTE +PW R RRAGVSSFGISGTNAHVI+E AP VE G++ G PV Sbjct 2458 AGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPV- 2516 Query 476 VPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQL 535 VPWV+SA+S AL QA RL A V + + + DVGWSL RS F+HRAVV+G DR L Sbjct 2517 VPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGVDRDGL 2575 Query 536 MEGLTGLAAG-VPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRC 594 + GL LA GA V+ G A GKT FVFPGQG+Q LGMG L A PVFAE + Sbjct 2576 LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEAFNTV 2635 Query 595 ERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHS 654 L H+ L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS Sbjct 2636 VGELDRHLLRPLREVIWGH-DENLLNTTEFAQPALFAVEVALYRLLESWGVRPDFVMGHS 2694 Query 655 QGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLN 714 GE++AA+VAG LSL +AA +VA R RL+ L G M+++ Q +++ G +++ Sbjct 2695 VGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAV---QATEQEVLPLLGAQVS 2751 Query 715 IAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRG 774 IAA+NG +SVV++G DAV+ + ++ A+G R R+ V +A HS +D + +E Sbjct 2752 IAAINGPASVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGE 2811 Query 775 IEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPH 834 + T+ S +TG+L +A YW R +R V+F ++R A G F+E P Sbjct 2812 LTVNAPTIGIISNLTGQLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFLEVGPS 2871 Query 835 PVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSA-GQAHVAGVGVDWRAAFA 893 L A IEE L D A P+ + R D +SA VAG VDWRA Sbjct 2872 SGLTASIEEVLSDA---AVTNPVATASALRKDRPEPVSLVSAVAGVFVAGTAVDWRAVVG 2928 Query 894 DLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTG 953 VELPTYAF R+RFWL AV D G+GL EH LL AVV+ P SGGVVLTG Sbjct 2929 Q--SNFVELPTYAFERRRFWLS-GDAVAADAAGLGLQAGEHALLGAVVELPASGGVVLTG 2985 Query 954 RISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VR 1012 R+S+ A WLADHAVG VV+FPG GFVELA+RAGDEVGC V+ ELTL APLVLP+ G V Sbjct 2986 RLSLAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVA 3045 Query 1013 VQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARA 1072 VQVVVG + SG R V VYS + D+ W LHA+G LG GS +PA +LS WPPVGA Sbjct 3046 VQVVVGSPDDSGARAVSVYS---RGDAGSDWVLHAEGSLGSGSPEPATDLSTWPPVGAVE 3102 Query 1073 MDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDA 1130 ++ ADGYQ LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFGIHP +LDA Sbjct 3103 VENADGYQQLAERGYGYGPAFRGLNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDA 3162 Query 1131 ALHA----------WGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELA 1180 ALHA +G+ EG ++PF+WQGV LHA+GA+ VR R+AP G AVS+EL+ Sbjct 3163 ALHAVILASDGADDFGVPEG--SVLVPFAWQGVTLHAAGASAVRARIAPAGPSAVSIELS 3220 Query 1181 DPQGLPVLSVRQLMVRPVSAAALSRSTAG---DRGLLEMIWT--------PVPL------ 1223 D GLPVLSV ++ RPV+ L + +G DR L + WT PVP+ Sbjct 3221 DGLGLPVLSVASMLARPVTDQQLRAAVSGAGPDR-LFGVDWTAQPSAELQPVPVRIWGAV 3279 Query 1224 --EGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTR 1281 EG D +VV+E P A G+V+A VY VLEVL+SWL+ D G V+ TR Sbjct 3280 ESEGDDDPGASVVFESVPQA-----GEVVAGVYAATAAVLEVLRSWLSRDGAGQLVITTR 3334 Query 1282 GAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLV 1341 GAV D+DVTDLAG+AVWGLVRSAQ EHPGR+VLVDTD + E AV +GEPQ++ Sbjct 3335 GAVALPDEDVTDLAGSAVWGLVRSAQTEHPGRIVLVDTDAQLD-EHAVAAVLAAGEPQVL 3393 Query 1342 VRRGRVYAARL--APVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPV--APVELATGQV 1397 R G VY AR+ + AGL +P G WRL GT ++ + P+ A L G V Sbjct 3394 WRNGEVYTARVHGSRAVAGLLVPPGD-GPWRLGMSTAGTFENLRLEPIPDADAALQPGHV 3452 Query 1398 RVAVGAVGVNFRDVLVALGMYPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-V 1455 RVA+ A+ NFRDV++ALG+YP +GV+GAGVVVE AVGDRV+GL Sbjct 3453 RVALSAMAANFRDVMIALGLYPDPDAAMGVEGAGVVVETASTDGRFAVGDRVVGLFPEGT 3512 Query 1456 GSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGM 1515 G+ A+ D RL+ +PAGWS AA V F TAFY L LA V GQ++LVHA TGGVGM Sbjct 3513 GTIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAATGGVGM 3572 Query 1516 AAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVL 1575 AAV LAR+WG EVF TAS+ KWDTLRAMGFD+ HI DSRSLEFE+ F AT G G+DVVL Sbjct 3573 AAVQLARHWGLEVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAATGGRGMDVVL 3632 Query 1576 NSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAM 1635 +SLAGEF DASLRL+ GG F+E+GKTDIR+ VA++H GVRYRAFDL EAGPD IA + Sbjct 3633 DSLAGEFVDASLRLVAPGGVFLEMGKTDIREAAVVAQQHTGVRYRAFDLFEAGPDHIAQI 3692 Query 1636 LSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGT 1695 L+E+ L + L LPV TFD R APAA R++SQARH+GKVVLT+PD A GT Sbjct 3693 LAELAALFSEDALRPLPVTTFDVRRAPAALRYLSQARHVGKVVLTMPD------AWAAGT 3746 Query 1696 VVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCD 1755 V++TGGTGMAGSA+A H+V HGV LVLVSR G A AAE+A L GAQV VV+CD Sbjct 3747 VLITGGTGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQVVACD 3806 Query 1756 VADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHEL 1815 ADR ALA L+A + ++PL V H AG LDDAV+T LTP+R++TVLRAKVD AWNLHEL Sbjct 3807 AADRAALAKLIADIPVQHPLSAVIHTAGALDDAVVTSLTPERMETVLRAKVDAAWNLHEL 3866 Query 1816 TEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQAS 1875 T DMDLSAFV+FSSMAG+VG+ QGNYAAAN+FLDGL +R++ GL +S+ WGLW+QAS Sbjct 3867 TRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLDGLAVHRQAHGLPAISLGWGLWDQAS 3926 Query 1876 AMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAAL--AGAGAA 1933 MT L D R + G+ +++++ALG LDTA+ ++ A +D AAL G Sbjct 3927 NMTGGLAAVDFKRFARDGIVAMSSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGT 3986 Query 1934 LPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR 1992 LP +F L PTRR++ D+ A S S L+ RL L + + L +LV S+ A VLG Sbjct 3987 LPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGN 4046 Query 1993 SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLV 2052 SS I+ +AFQ+LGFDSLTAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ LV Sbjct 4047 SSPDAIDPDRAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMHRELV 4106 Query 2053 TAS 2055 AS Sbjct 4107 GAS 4109 >gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] gi|118569895|gb|ABL04646.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] Length=4191 Score = 2255 bits (5844), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1262/2081 (61%), Positives = 1503/2081 (73%), Gaps = 43/2081 (2%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR R LL R++EP+A+VGM CR+PGGVDSPE LW++VA GRD +S+ Sbjct 10 EALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVAEGRDVMSD 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+A LFDPDPD KSY GGF+ VA FD FFGIAPSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLADLFDPDPDTPHKSYASTGGFVDGVADFDPGFFGIAPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALER+GIDP LRGS TGVFAG+ YG ++E Y L G T SVASGRV Sbjct 130 ELSWEALERSGIDPTGLRGSATGVFAGLIVQGYG---MFAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGR KAYAGAADG ++EG +LV+ RL+DA+RLGHPVLALVRGSAVNQDGASNGL Sbjct 247 GLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR-----P 364 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGSAGA 366 Query 365 ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSL 424 A + LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH VLP TLHVDVP+PHVDWSAGAV L Sbjct 367 AGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWSAGAVEL 426 Query 425 LTEPRPWHVPG---RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 LTE +PW R RRAGVSSFGISGTNAHVI+E AP VE G++ G PV VPWV+S Sbjct 427 LTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPV-VPWVVS 485 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A V + + + DVGWSL RS F+HRAVV+GADR L+ GL Sbjct 486 AKSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRDGLLAGLDE 544 Query 542 LAAG-VPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALRE 600 LA GA V+ G A GKT FVFPGQG+QW+GMG +L TAPVFA HI C +A E Sbjct 545 LAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTAPVFARHIESCGQAFAE 604 Query 601 HVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAA 660 V+WSLLDVLRGA GAPGLDR+DVVQP L+AVMVSLAELW+SVGV PDAVIGHSQGEIAA Sbjct 605 FVDWSLLDVLRGAAGAPGLDRIDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEIAA 664 Query 661 AYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNG 720 AYVAGALSLRDAA VV LRS+LLV L G GGMVS+ACG+ QA +L +GDR++IAA+NG Sbjct 665 AYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAING 724 Query 721 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTS 780 S+VV++GE A+ EL+ +C +R RRIDVDYASHS +V+AI +L L GIEP +S Sbjct 725 PSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPLSS 784 Query 781 TVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG 840 AFFS+VTG +DTA ++AEYWYR+IRQ VQF++AVR+A GYR F+ESSPHP LIAG Sbjct 785 RTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAVRSACGHGYRTFIESSPHPALIAG 844 Query 841 IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRV 900 IE+T +C + +PIV+PTLGR+DGG+ RF SA A VAGV VDWR G V Sbjct 845 IEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAAAAFVAGVNVDWRGPLD--GAGLV 902 Query 901 ELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAA 960 ELPTYAF ++RFWL G G V D G+GL H LL AVV+ P+SGGVVLTGR+++ A Sbjct 903 ELPTYAFEKRRFWLSGEG-VSVDASGLGLSAGGHALLGAVVELPESGGVVLTGRLALGAH 961 Query 961 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGG 1019 WLADHAV VV+FPGTGFVELA+RA DEVGCSV+ ELTL+ PLVLPA G V VQVVVG Sbjct 962 GWLADHAVSGVVVFPGTGFVELAIRAVDEVGCSVVNELTLRTPLVLPASGSVAVQVVVGA 1021 Query 1020 VEQSGTRNVWVYSAAGQADSSPG---WTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVA 1076 S R+V +YS + W HA+G LG S QPAA+LS WPP GA A+DVA Sbjct 1022 AADSAERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAIAVDVA 1081 Query 1077 DGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGV-PIRGFGIHPAVLDAALHAW 1135 DGY+ L ARGYGYGPAFRGL A+W RG E+FA+ LPE GFG+HPA+LDAALH Sbjct 1082 DGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAGSTSGFGVHPALLDAALHTA 1141 Query 1136 GIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMV 1195 I + +LPFSWQGV LHA+GAA VRVR+APVG +VSVELAD GLPVLSV+ ++ Sbjct 1142 VIANPDADLVLPFSWQGVSLHAAGAASVRVRIAPVGPSSVSVELADDLGLPVLSVKAMVA 1201 Query 1196 RPVSAAALSR--STAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAV 1253 RPVS + S +G L E++WTP+ + D A +EL A GD L+ Sbjct 1202 RPVSEQQMRAVVSASGPDRLFEVVWTPMTVAATDA---APAYEL--FESIAADGDPLSGT 1256 Query 1254 YRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGR 1313 Y+ H+ L +QSWL +G+ VV TRGA+ +DVTDLAGAAVWGLVRSAQ E+PGR Sbjct 1257 YQRTHQALAAVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPGR 1316 Query 1314 VVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGLTLPSASAGGWRL 1371 +VLV + AV GEPQ+V+R G+ Y AR+ + A G+ +P G WRL Sbjct 1317 LVLV-DSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILVPPVD-GPWRL 1374 Query 1372 VAGGGGTLADVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGA 1429 GT ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ +G +GA Sbjct 1375 GLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALIGGEGA 1434 Query 1430 GVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLT 1487 GVVVE+GP VT AVGD V G GS +V D RL+ PA WS EAAA+ F T Sbjct 1435 GVVVEIGPEVTEFAVGDAVYGFFP-DGSGTLVAGDVRLLLPKPADWSYAEAAAISAVFTT 1493 Query 1488 AFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDD 1547 A+Y LA V GQ+VLVHA TGGVGMAAV LAR+ G EV+ TAS+ KWD LRAMGFD+ Sbjct 1494 AYYAFVHLANVQPGQRVLVHAATGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDE 1553 Query 1548 IHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDG 1607 HISDSRSLEFEE F T G VDVVL+SLAGEF DASLRLL GG F+E+GKTDIRD Sbjct 1554 DHISDSRSLEFEEKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDP 1613 Query 1608 QTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRF 1667 +A+ + GVRYRAFDL E G R+ + ++ GL AGVL LPV FD R APAA R+ Sbjct 1614 GVIAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVRRAPAALRY 1673 Query 1668 VSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSR 1727 +SQARH+GKVV+T+P GG L GGTV++TGGTGMAGSA+A HLV HGVA+LVL+SR Sbjct 1674 LSQARHVGKVVMTMPADQGG--ALGGGTVLITGGTGMAGSALARHLVAHHGVAHLVLISR 1731 Query 1728 SGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDD 1787 G A A E+ A L GAQV VV+CD ADR ALA ++A + PL V HA GVLDD Sbjct 1732 RGPAAPGATELVAELSAAGAQVEVVACDAADRPALAKVIAENPAQRPLSAVVHAGGVLDD 1791 Query 1788 AVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANA 1847 AVI+ LTP+RVDTVLRAKVD AWNLHELT D+DLSAFV+FSSMAG+VG+ Q NYAAAN Sbjct 1792 AVISSLTPERVDTVLRAKVDAAWNLHELTRDLDLSAFVMFSSMAGVVGSSGQANYAAANT 1851 Query 1848 FLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLD 1907 F+DGL A+RR+ GL +S+ WGLW+QAS MT + DRAR+ + G+ L++++A+ D Sbjct 1852 FVDGLAAHRRAHGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFD 1911 Query 1908 TALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAA-DTAVSMSGLVSRL 1966 TAL ++A + AR+D AAL A+P +FS L + PTRR+IDAA TA S S L RL Sbjct 1912 TALIVNQAFLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQIDAALATAKSKSALAHRL 1971 Query 1967 HALTPERRQRELT-DLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTAT 2025 H L PE Q + DLV S+ A VLG + I+ KAFQ+LGFDSLTAVE+RNR+KT T Sbjct 1972 HGL-PELEQHAVVLDLVRSHIATVLGTITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVT 2030 Query 2026 GLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRV 2066 GL+LSPTLIFDYPTP LA ++ + L A + + + RV Sbjct 2031 GLSLSPTLIFDYPTPNGLANYIRAELAGAPQEVKHTPAVRV 2071 Score = 2025 bits (5246), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1172/2103 (56%), Positives = 1426/2103 (68%), Gaps = 84/2103 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + +P+A+VGM CRYPGG++SP+ LW+++ Sbjct 2044 TPNGLANYIRAELAGAPQEVKHTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR 2103 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +S+FPADRGWD+AGLF+PDPD G YTR GGF+ V F+ FFG+ PSEALAMDP Sbjct 2104 RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFEPAFFGVGPSEALAMDP 2163 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+ LE+SWEALERAGI+P LRGS TGVFAGV YG P +E + L G S Sbjct 2164 QQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2221 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GGVT+ ATP +F+ Sbjct 2222 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPDIFV 2281 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LSADGRCKA+AGAADGT F+EG G+LV+ RL+DA+RLGHPVLALVRGSAVNQD Sbjct 2282 EFSRWRGLSADGRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQD 2341 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2342 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2401 Query 364 -----PADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWS 418 A + LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH VLP TLHVDVP+PHVDWS Sbjct 2402 RGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWS 2461 Query 419 AGAVSLLTEPRPWHVPG---RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVA 475 AGAV LLTE +PW R RRAGVSSFGISGTNAHVI+E AP VE G++ G PV Sbjct 2462 AGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPV- 2520 Query 476 VPWVLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQL 535 VPWV+SA+S AL QA RL A V + + + DVGWSL RS F+HRAVV+GADR L Sbjct 2521 VPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRDGL 2579 Query 536 MEGLTGLAAG-VPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRC 594 + GL LA GA V+ G A GKT FVFPGQG+Q LGMG L A PVFAE + Sbjct 2580 LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEAFNTV 2639 Query 595 ERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHS 654 L H+ L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS Sbjct 2640 VGELDRHLLRPLREVIWGH-DENLLNTTEFAQPALFAVEVALYRLLESWGVRPDFVMGHS 2698 Query 655 QGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLN 714 GE++AA+VAG LSL +AA +VA R RL+ L G M+++ Q +++ G +++ Sbjct 2699 VGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAV---QATEQEVLPLLGAQVS 2755 Query 715 IAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRG 774 IA +NG +SVV++G DAV+ + ++ A+G R R+ V +A HS +D + +E Sbjct 2756 IATINGPASVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGE 2815 Query 775 IEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPH 834 + T+ S +TG+L +A YW R +R V+F ++R A G F+E P Sbjct 2816 LTVNAPTIGIISNLTGQLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFLEVGPS 2875 Query 835 PVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSA-GQAHVAGVGVDWRAAFA 893 L A IEE L D A P+ + R D +SA VAG VDWRA Sbjct 2876 IGLTASIEEVLSDA---AVTNPVATASALRKDRPEPVSLVSALAGVFVAGTAVDWRAVVG 2932 Query 894 DLGGRRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTG 953 VELPTYAF R+RFWL G AV D G+GL EH LL AVV+ P SGGVVLTG Sbjct 2933 Q--SHFVELPTYAFERRRFWLSG-DAVPADAAGLGLQAGEHALLGAVVELPASGGVVLTG 2989 Query 954 RISVVAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VR 1012 R+S+ A WLADHAVG VV+FPG GFVELA+RAGDEVGC V+ ELTL APLVLP+ G V Sbjct 2990 RLSLAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVA 3049 Query 1013 VQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARA 1072 VQVVVG + SG R V VYS + D+ W LHA+G LG GS +PA +LS WPPVGA Sbjct 3050 VQVVVGSPDDSGARAVSVYS---RGDAGSDWVLHAEGSLGSGSPEPATDLSTWPPVGAVE 3106 Query 1073 MDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDA 1130 ++ ADGYQ LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFGIHP +LDA Sbjct 3107 VENADGYQQLAERGYGYGPAFRGLNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDA 3166 Query 1131 ALHA----------WGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELA 1180 ALHA +G+ EG ++PF+WQGV LHA+GA+ VR R+AP G AVS+EL+ Sbjct 3167 ALHAVILASDGADDFGVPEG--SVLVPFAWQGVTLHAAGASAVRARIAPAGPSAVSIELS 3224 Query 1181 DPQGLPVLSVRQLMVRPVSAAALSRSTAG---DRGLLEMIWT--------PVPL------ 1223 D GLPVLSV ++ RPV+ L + +G DR L + WT PVP+ Sbjct 3225 DGLGLPVLSVASMLARPVTDQQLRAAVSGAGPDR-LFGVDWTAQPSAELQPVPVRIWGTV 3283 Query 1224 --EGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTR 1281 EG D +VV+E P A G+V+A VY VLEVL+SWL+ D G ++ TR Sbjct 3284 ESEGDDDPGASVVFESVPQA-----GEVVAGVYAATAAVLEVLRSWLSRDGAGQLIITTR 3338 Query 1282 GAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLV 1341 GAV D+DVTDLAG+AVWGLVRSAQ EHPGR+VLVDTD + E AV +GEPQ++ Sbjct 3339 GAVALPDEDVTDLAGSAVWGLVRSAQTEHPGRIVLVDTDAQLD-EHAVAAVLAAGEPQVL 3397 Query 1342 VRRGRVYAARL--APVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPV--APVELATGQV 1397 R G VY AR+ + AGL +P G WRL GT ++ + P+ A L G V Sbjct 3398 WRNGEVYTARVHGSRAVAGLLVPPGD-GPWRLGMSTAGTFENLRLEPIPDADAALQPGHV 3456 Query 1398 RVAVGAVGVNFRDVLVALGMYPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-V 1455 RVA+ A+ NFRDV++ALG+YP +GV+GAGVVVE AVGDRV+GL Sbjct 3457 RVALSAMAANFRDVMIALGLYPDPDAAMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGT 3516 Query 1456 GSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGM 1515 G+ A+ D RL+ +PAGWS AA V F TAFY L LA V GQ++LVHA TGGVGM Sbjct 3517 GTIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAATGGVGM 3576 Query 1516 AAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVL 1575 AAV LAR+WG EVF TAS+ KWDTLRAMGFD+ HI DSRSLEFE+ F AT G G+DVVL Sbjct 3577 AAVQLARHWGLEVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAATGGRGMDVVL 3636 Query 1576 NSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAM 1635 +SLAGEF DASLRL+ GG F+E+GKTDIR+ VA++H GVRYRAFDL EAGPD IA + Sbjct 3637 DSLAGEFVDASLRLVAPGGVFLEMGKTDIREAAVVAQQHTGVRYRAFDLFEAGPDHIAQI 3696 Query 1636 LSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGT 1695 L+E+ L + VL LPV TFD R APAA R++SQARH+GKVVLT+PD A GT Sbjct 3697 LAELAALFSEDVLRPLPVTTFDVRRAPAALRYLSQARHVGKVVLTMPD------AWAAGT 3750 Query 1696 VVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCD 1755 V++TGGTGMAGSA+A H+V HGV LVLVSR G A AAE+A L GAQV VV+CD Sbjct 3751 VLITGGTGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQVVACD 3810 Query 1756 VADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHEL 1815 ADR ALA L+A + ++PL V H AG LDDAV+T LTP+R++TVLRAKVD AWNLHEL Sbjct 3811 AADRAALAKLIADIPMQHPLSAVIHTAGALDDAVVTSLTPERIETVLRAKVDAAWNLHEL 3870 Query 1816 TEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQAS 1875 T DMDLSAFV+FSSMAG+VG+ QGNYAAAN+FLDGL +R++ GL +S+ WGLW+QAS Sbjct 3871 TRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLDGLAVHRQAHGLPAISLGWGLWDQAS 3930 Query 1876 AMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAAL--AGAGAA 1933 MT L D R + G+ +++++ALG LDTA+ ++ A +D AAL G Sbjct 3931 NMTGGLAAVDFKRFARDGIVAMSSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGT 3990 Query 1934 LPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR 1992 LP +F L PTRR++ D+ A S S L+ RL L + + L +LV S+ A VLG Sbjct 3991 LPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGN 4050 Query 1993 SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLV 2052 SS I+ +AFQ+LGFDSLTAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ LV Sbjct 4051 SSPDAIDPDRAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMHRELV 4110 Query 2053 TAS 2055 AS Sbjct 4111 GAS 4113 >gi|296164561|ref|ZP_06847131.1| erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295900085|gb|EFG79521.1| erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] Length=2122 Score = 2241 bits (5808), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1354/2146 (64%), Positives = 1562/2146 (73%), Gaps = 70/2146 (3%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 V L+R R +R +L + +EP+AVVGM CRY GGVDSPE LW+LV GRD VS Sbjct 17 VDYLKRLTADLRRARRRVAELEGKLSEPIAVVGMACRYAGGVDSPEALWQLVNDGRDTVS 76 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 +FPADRGWDV GL+DPDPDA GK YTR G FL D FDA FFGI PSEALAMDPQQR++ Sbjct 77 DFPADRGWDVEGLYDPDPDAAGKMYTRQGSFLRDAGDFDAGFFGIGPSEALAMDPQQRVM 136 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LE+SWEALERAGIDP+ LRGS TGVFAGV H YGG+ V G+LE YGL GSTLSVASGR Sbjct 137 LEISWEALERAGIDPLGLRGSATGVFAGVIHAGYGGE--VKGELEGYGLTGSTLSVASGR 194 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 V+YVLGL+GPAVSVDTACSSSLVA+HLA QSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 195 VSYVLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 254 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 RAL+ DGRCK YAGAADGT+++EGAGVLVL RLADARRLGHPVLA++RGSAVNQDGASNG Sbjct 255 RALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVLAVLRGSAVNQDGASNG 314 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RPADR 367 L PNGP+QQRVI AALA A L ADVDVVEGHGTGT LGDPIEAQA+LATYGQ RP R Sbjct 315 LTAPNGPSQQRVIRAALADAGLTAADVDVVEGHGTGTVLGDPIEAQALLATYGQDRPPGR 374 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+P+TLHVDVP+PHVDWS GAVSLLTE Sbjct 375 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVIPRTLHVDVPSPHVDWSVGAVSLLTE 434 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVG---AAHGND--PVAVPWVLSA 482 P+PW RRAGVSSFGISGTNAHVI+EE PA AA +D PV VPWV+SA Sbjct 435 PQPWPARDGGRRAGVSSFGISGTNAHVIVEEPPAEPETPEAVAAQTDDSRPV-VPWVVSA 493 Query 483 RSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGL 542 RSA AL QA RL A++ A+ +RP DVGWSL TR+ +HRAV+VG+DR L GL G+ Sbjct 494 RSADALAAQAARLSAYLDAEPGLRPRDVGWSLATTRAALEHRAVLVGSDRDTLRAGLAGV 553 Query 543 AAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHV 602 A+G PG V GR+++ GK AFVFPGQGAQ LGMG +L P FAE A+ H Sbjct 554 ASGEPGPGAVVGRSRSTGKRAFVFPGQGAQRLGMGRELHQRFPAFAEAFDEAVAAVDAHA 613 Query 603 EWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAY 662 L +V+ G L + QPAL+ + V+LA LWRS GV PD VIGHS GEIAAA+ Sbjct 614 RRPLREVMWGT-DPELLQSTEFAQPALFVLEVALAALWRSWGVTPDVVIGHSVGEIAAAH 672 Query 663 VAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVS 722 VAG LSLRDAA +VA R RL+ L G MV++ + + L +++AAVNG + Sbjct 673 VAGVLSLRDAARLVAARGRLMAALPPGGVMVAVTATEAEVAPLLD---GGVSLAAVNGPA 729 Query 723 SVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTV 782 +VVL+GE DAVT R G R R++ V +A HS ++ + EE A G+ P + + Sbjct 730 AVVLSGERDAVTAAADRLADCGRRVRQLAVSHAFHSPLMEPMIEEFSAVAAGVSPGSPRI 789 Query 783 AFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIE 842 S VTG +A+YW +R+PV+F R A G FVE P L A +E Sbjct 790 DLVSNVTGRPAGPGYGSADYWVEHVRRPVRFADGARCAAALGAGAFVEVGPGAALTAAVE 849 Query 843 ETLVDCDRGATGEPIVIP-TLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 ++L EP V ++ +D V L+AGQ +G +DW AAFA L RV+ Sbjct 850 QSL-------GAEPAVAAVSMAKDHPEVDSLLLAAGQLFASGADLDWAAAFAGLAAHRVD 902 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAFAR+RFWL G D G+GL A H LL AVV+RPDSGGVVLTGR+S VA P Sbjct 903 LPTYAFARRRFWLLSESVGGRDTAGLGLAAAGHALLGAVVERPDSGGVVLTGRLSTVAQP 962 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADHAV VLFPG GFVEL LRAGDEVGC V++EL L APL LPA G V VQVVV G Sbjct 963 WLADHAVAGTVLFPGAGFVELMLRAGDEVGCPVIEELMLSAPLPLPAAGAVCVQVVVDGA 1022 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 + G+R VYS AG WTLHAQGVLG GS P A+LSVWPPVGA A+DVA Y Sbjct 1023 GEGGSRAAAVYSQAGSQ-----WTLHAQGVLGEGSPAPDADLSVWPPVGATAVDVAGAYD 1077 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL+A+WRRGAEVFA+V P+ GV + GFGIHP VLDAALHA G+ Sbjct 1078 DLAGRGYGYGPAFRGLRAVWRRGAEVFAEVEAPQDAGVAVGGFGIHPVVLDAALHALGVA 1137 Query 1139 EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPV 1198 + +T+LPFSWQGVCLHA+GA+RVRVRLAP G+ AVSVELAD GLPVLSVR+L+ RPV Sbjct 1138 DEGAETVLPFSWQGVCLHAAGASRVRVRLAPAGKDAVSVELADSSGLPVLSVRELVTRPV 1197 Query 1199 SAAALSRSTAGDRG---LLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGD-VLAAVY 1254 SAA LS + A G LLE +W+PV L G VW P A GD V+A+V+ Sbjct 1198 SAAQLSAAAAARTGGGELLEAVWSPVALPDNPDGPAPEVWRPP------ANGDGVVASVH 1251 Query 1255 RGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRV 1314 H L +LQS + + VV+TRGAV +DVTDLAGAAVWGLVRSAQAE+PGRV Sbjct 1252 AATHAALGLLQS--RDEGSAPLVVLTRGAVALPGEDVTDLAGAAVWGLVRSAQAENPGRV 1309 Query 1315 VLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGWRLV 1372 VLVD+DGS+ VG GEPQLVVR G + ARLAPV L LP + WRL Sbjct 1310 VLVDSDGSLDPRAVVG----CGEPQLVVRGGVAHRARLAPVKVHPVLRLPEPPSV-WRLA 1364 Query 1373 AGGGGTLADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVV 1432 AG GTL D+ V P EL GQVRVAV A GVNFRDVLVALGMYPG +LG +GAG+V Sbjct 1365 AGDAGTLEDLAVQSGPPAELLAGQVRVAVAAAGVNFRDVLVALGMYPGAAQLGAEGAGLV 1424 Query 1433 VEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGL 1492 EVGPGVT LAVGD V+G+LGL GSEAVVD RLVT VP WSL EAA VPV FLTA YGL Sbjct 1425 AEVGPGVTDLAVGDAVLGILGLTGSEAVVDRRLVTRVPPDWSLAEAAGVPVVFLTALYGL 1484 Query 1493 SVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISD 1552 SVLA + AG++VLVHA GGVGMAAV LAR+WGAEVF TASR KW+TLRAMGFDD HI+D Sbjct 1485 SVLAGLRAGERVLVHAAAGGVGMAAVQLARHWGAEVFATASRGKWETLRAMGFDDAHIAD 1544 Query 1553 SRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAE 1612 SR+LEFEE F AT G+GVDVVLNSLAGEFTDASLRLL GGRFIE+GKTD+RD T+ Sbjct 1545 SRTLEFEEKFSAATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDLRDPDTLT- 1603 Query 1613 RHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQAR 1672 GV YRAFDL+EAGPDRIA ML+E++ L AAGVL LPV+ FD RCA AYRFVSQAR Sbjct 1604 ---GVGYRAFDLMEAGPDRIAEMLAELMRLFAAGVLKPLPVRAFDIRCAADAYRFVSQAR 1660 Query 1673 HIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQA 1732 HIGKVVLT+P G +GLAGGT +VTGGTGMAGSAVA HLV R+ V +++LVSR GE+A Sbjct 1661 HIGKVVLTMPG---GPAGLAGGTALVTGGTGMAGSAVARHLVERYRVPHVMLVSRGGERA 1717 Query 1733 DRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITG 1792 + LR GA+V VV+CDV D +A+A LLA + R+PL+GVFHAAGVLDDAVI Sbjct 1718 AGVPGLVDGLRATGAEVTVVACDVGDPEAVAGLLARVPARFPLRGVFHAAGVLDDAVIAS 1777 Query 1793 LTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGL 1852 LTP RVDTVLR+K DGAW+LHELT +DLSAFV+FSSMAGIVG P QGNYAAAN+FLDGL Sbjct 1778 LTPQRVDTVLRSKADGAWHLHELTRGLDLSAFVMFSSMAGIVGAPGQGNYAAANSFLDGL 1837 Query 1853 VAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQA 1912 A+RR+ GL GLSVAWG+W + SAMT HLGERD+ARM++AGLA L+T QAL LD AL A Sbjct 1838 AAHRRAHGLPGLSVAWGMWAEESAMTGHLGERDKARMSRAGLAALSTGQALDLLDAALLA 1897 Query 1913 DRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMSGLVSRLHALTPE 1972 + VVVA RLD ALA AGAALP L SQLAA P RR +D D VS++GL +RL L PE Sbjct 1898 EPPVVVATRLDATALAHAGAALPPLLSQLAARPARRVLDPTDM-VSLTGLRARLDGLAPE 1956 Query 1973 RRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPT 2032 +R+REL +LV NAA VLG S++ D++A +AF DLGFDSLTAVELRNRLK ATGLTLSPT Sbjct 1957 QRRRELVELVCGNAATVLGHSTA-DVDAEQAFADLGFDSLTAVELRNRLKIATGLTLSPT 2015 Query 2033 LIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRT 2092 LIFD+PTPA LAEHLD +L + + R +D+ REL LL +PD S KA L Sbjct 2016 LIFDHPTPAALAEHLDGQLAAGTSAQPPDRMARFNDVARELQALLGRPDWSPGDKAQLVA 2075 Query 2093 RLQTMLTSLT-------------TEDDDIAAATESQLFAILDEELG 2125 RL+ +L++L DDDIA ATESQLFAILDEE+G Sbjct 2076 RLEGLLSTLAGPAQPPHPEDPDDPFDDDIATATESQLFAILDEEIG 2121 >gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] gi|148721791|gb|ABR06416.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] Length=4151 Score = 2212 bits (5733), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1262/2056 (62%), Positives = 1492/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL EAGPDRIA +L+E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1609 VRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 2003 bits (5188), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1166/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990428|ref|YP_002645115.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|121493581|emb|CAL72055.1| Probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224773541|dbj|BAH26347.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601971|emb|CCC64645.1| probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Moreau RDJ] Length=4151 Score = 2209 bits (5723), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1261/2056 (62%), Positives = 1491/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL EAGPDRIA +L+E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEAGPDRIAQILAELATLFGDGVLRLLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 1995 bits (5168), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1164/2091 (56%), Positives = 1413/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPRVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYG AFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGLAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD R APAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRRAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL+LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLSLSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_11001 [Mycobacterium tuberculosis KZN R506] Length=4152 Score = 2208 bits (5722), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1260/2056 (62%), Positives = 1488/2056 (73%), Gaps = 40/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPDA G YTR GGF+ V FD FFG+ PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSSVASGRV 187 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 188 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 247 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 248 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 307 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 308 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 367 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 368 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 427 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 428 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 485 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 486 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 544 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 545 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 604 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 605 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 664 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 665 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 724 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 725 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 784 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 785 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 844 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 845 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 901 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 902 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 960 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 961 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1020 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1021 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1077 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1078 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1137 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1138 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1197 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1198 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1251 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1252 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1311 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1312 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1370 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1371 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1430 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1431 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1489 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1490 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1549 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1550 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1609 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL EAGPDRIA +L+E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1610 VRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1669 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1670 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1723 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1724 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1783 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1784 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1843 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1844 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1903 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1904 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1963 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1964 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2023 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2024 DYPTPNRLASYIRTEL 2039 Score = 2003 bits (5190), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1167/2091 (56%), Positives = 1413/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2027 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2086 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGLFDPDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2087 RDVLSEFPADRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2146 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 Q R+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2147 QHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2204 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2205 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2264 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2265 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2324 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2325 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2384 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2385 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2444 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2445 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2502 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2503 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2561 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2562 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2621 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2622 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2680 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2681 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2737 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2738 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2797 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2798 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2857 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2858 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2909 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2910 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2968 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2969 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3028 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3029 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3085 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3086 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3145 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3146 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3205 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3206 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3265 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3266 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3320 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3321 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3379 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3380 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3438 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3439 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3498 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3499 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3558 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3559 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3618 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3619 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3678 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3679 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3732 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3733 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3792 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3793 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3852 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3853 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3912 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3913 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3972 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3973 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4032 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4033 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4083 >gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobacterium bovis AF2122/97] gi|31618823|emb|CAD96927.1| Probable polyketide synthase pks12 [Mycobacterium bovis AF2122/97] Length=4151 Score = 2208 bits (5722), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1261/2056 (62%), Positives = 1491/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL EAGPDRIA +L+E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 2008 bits (5203), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1167/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D +GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAASLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA+V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD R APAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRRAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L RLH L + + L DLV S+ A VLG +S I+ +AFQDLGFDSL Sbjct 3972 LAAAKSKSALAHRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQDLGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL+LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLSLSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_10901 [Mycobacterium tuberculosis KZN 4207] gi|313658946|ref|ZP_07815826.1| hypothetical protein MtubKV_11016 [Mycobacterium tuberculosis KZN V2475] Length=4152 Score = 2208 bits (5721), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1260/2056 (62%), Positives = 1488/2056 (73%), Gaps = 40/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPDA G YTR GGF+ V FD FFG+ PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSSVASGRV 187 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 188 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 247 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 248 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 307 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 308 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 367 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 368 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 427 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 428 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 485 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 486 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 544 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 545 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 604 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 605 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 664 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 665 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 724 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 725 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 784 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 785 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 844 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 845 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 901 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 902 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 960 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 961 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1020 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1021 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1077 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1078 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1137 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1138 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1197 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1198 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1251 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1252 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1311 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1312 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1370 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1371 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1430 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1431 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1489 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1490 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1549 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1550 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1609 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL EAGPDRIA +L+E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1610 VRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1669 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1670 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1723 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1724 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1783 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1784 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1843 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1844 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1903 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1904 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1963 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1964 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2023 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2024 DYPTPNRLASYIRTEL 2039 Score = 2002 bits (5187), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1166/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2027 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2086 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2087 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2146 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2147 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2204 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2205 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2264 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2265 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2324 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2325 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2384 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2385 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2444 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2445 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2502 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2503 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2561 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2562 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2621 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2622 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2680 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2681 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2737 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2738 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2797 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2798 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2857 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2858 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2909 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2910 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2968 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2969 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3028 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3029 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3085 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3086 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3145 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3146 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3205 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3206 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3265 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3266 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3320 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3321 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3379 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3380 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3438 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3439 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3498 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3499 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3558 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3559 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3618 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3619 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3678 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3679 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3732 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3733 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3792 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3793 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3852 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3853 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3912 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3913 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3972 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3973 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4032 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4033 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4083 >gi|41407894|ref|NP_960730.1| Pks12 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396248|gb|AAS04113.1| Pks12 [Mycobacterium avium subsp. paratuberculosis K-10] Length=4170 Score = 2206 bits (5716), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1251/2081 (61%), Positives = 1505/2081 (73%), Gaps = 72/2081 (3%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA GRD +S Sbjct 9 TEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEALWQMVAEGRDVIS 68 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 EFP DRGWD+A L+DPDPDA K Y GGF+ +VA FD FFGIAPSEALAMDPQQR+ Sbjct 69 EFPTDRGWDLAALYDPDPDARHKCYVNTGGFVDNVADFDPAFFGIAPSEALAMDPQQRMF 128 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LE+SWEALERAGIDP+ LRGS TGVFAG+ YG + ++E Y L G T SVASGR Sbjct 129 LELSWEALERAGIDPVKLRGSATGVFAGLIVQGYG---MLAEEIEGYRLTGMTSSVASGR 185 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 V+YVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+EFSR Sbjct 186 VSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRH 245 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 R L+ DGRCKAYAGAADG ++EG +LV+ RL+DARRLGH VLA+VRGSAVNQDGASNG Sbjct 246 RGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHSVLAVVRGSAVNQDGASNG 305 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADR- 367 L PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ DR Sbjct 306 LTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQ---DRG 362 Query 368 -PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLT 426 PLWLGSIKSN+GHT AAAGVAGVIKMV AMRH +LP TLHVD P+PHVDWSAGAVSLLT Sbjct 363 QPLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLT 422 Query 427 EPRPWHVPG-RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPV--AVPWVLSAR 483 E +PW PG RPRRAGVSSFGISGTNAHVI+E PA EP AH + P +PW++SA+ Sbjct 423 EAQPW--PGERPRRAGVSSFGISGTNAHVIIEAVPAAEP---AHADAPALPVLPWMVSAK 477 Query 484 SAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLA 543 SA AL QA RL +V A + DVGW+L R+ F+HRAVVVG DR +L+ GL L+ Sbjct 478 SAAALRAQAARLAEYVRAHGELDIADVGWTLAG-RATFEHRAVVVGGDRDRLLAGLDELS 536 Query 544 AGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVE 603 P A ++ G A GKT FVFPGQG+QWLGM +L TAPVFA+HI CE A E V+ Sbjct 537 TDDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFAQHIQACEEAFAEFVD 596 Query 604 WSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYV 663 WSL+D LRGAPGA G+DRVDVVQPAL+AVMVSLAELW+SVGV PDAVIGHSQGEIAAAYV Sbjct 597 WSLIDALRGAPGAAGMDRVDVVQPALFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYV 656 Query 664 AGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSS 723 AGALSLRDAA VV LRS+LL L G GGM+S+AC +A +L + +G+R++IAAVNG SS Sbjct 657 AGALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSS 716 Query 724 VVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVA 783 VV++GE A+ EL C +R RRIDVDYASHS +V+AIRE+L AL GIEPR+S +A Sbjct 717 VVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPRSSRIA 776 Query 784 FFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEE 843 FFSTVTG +DTAG++A+YWYR+IRQ VQF++AVR+A + GYR F+ESSPHP L+AGIE+ Sbjct 777 FFSTVTGNRLDTAGLDADYWYRNIRQTVQFDQAVRSAAEHGYRTFIESSPHPALVAGIED 836 Query 844 TLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELP 903 T+ D G T E IVIPTLGRDDGG+ RF SA A VAGV V WR G VELP Sbjct 837 TVNDSLPGDT-EAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWRGVLD--GAGFVELP 893 Query 904 TYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWL 963 TYAF R+RFWL G GA D G+GL +EH LL+AVV+ P SGGVVLTGR+S WL Sbjct 894 TYAFDRRRFWLSGEGA-AADASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWL 952 Query 964 ADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAD-----GVRVQVVVG 1018 DHAV V+FPG GFVELA+RAGDEVGCS ++ELTLQAPL+LPA V VQVVVG Sbjct 953 TDHAVSGTVVFPGAGFVELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVVVG 1012 Query 1019 GVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADG 1078 ++SG R+V ++S + DS W HAQG L GS++P A+LS WPP GA +D+ADG Sbjct 1013 EADESGRRDVSIFS---RPDSDSPWVCHAQGTLSTGSIEPGADLSAWPPAGATKVDIADG 1069 Query 1079 YQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGV-PIRGFGIHPAVLDAALHAWGI 1137 YQ LAARGYGYGPAF+GL A W RG EVFA+V LP+ + GFG+HPA+LDAA+HA + Sbjct 1070 YQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTGFGVHPALLDAAMHA--L 1127 Query 1138 VEGEQ------QTMLPFSWQGVCLHASGAARVRVRLAP------VGRGAVSVELADPQGL 1185 + G Q + +LPF+WQGV LHA+GA+ VR RLAP AVS+ELAD GL Sbjct 1128 IVGHQIAGDRDEVVLPFAWQGVSLHAAGASAVRARLAPAQAPGTAASRAVSLELADGLGL 1187 Query 1186 PVLSVRQLMVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGA 1243 PVLSVR ++ R VS L + S AG L E+ W PV + A E P H Sbjct 1188 PVLSVRAMVARSVSERQLRAAVSAAGPDRLFEVAWAPVTVP-------AAHGEPPVHQVF 1240 Query 1244 Q---AGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVW 1300 + A GD + YR HE L +QSWL +G+ VVVTRGA+ +DVTDL+GAAVW Sbjct 1241 ESLAAEGDPVGESYRRTHEALAAVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVW 1300 Query 1301 GLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAA--G 1358 GLVRSAQ EHPGR+VL+D+D ++ + A+ +GEPQ+++R G VY AR+ A G Sbjct 1301 GLVRSAQTEHPGRIVLIDSDAALD-DSALTAALATGEPQVLLRDGTVYTARVHGSRAVDG 1359 Query 1359 LTLPSASAGGWRLVAGGGGTLADVVVAPVAPVE--LATGQVRVAVGAVGVNFRDVLVALG 1416 + P WRL GT ++ + PV + L GQVRVA+ A+ NFRDV++ LG Sbjct 1360 IMTPPEDR-PWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRDVMITLG 1418 Query 1417 MYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWS 1474 M+ LG +GAGVVVEVGPGVT +VGD V G GS +V D RL+ PA WS Sbjct 1419 MFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFP-DGSGTLVPGDVRLLQHKPAHWS 1477 Query 1475 LVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASR 1534 EAA + F TA+ LA+V GQ+VLVHA GGVGMAAV LAR+ G EVF TASR Sbjct 1478 YPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMAAVQLARHLGLEVFATASR 1537 Query 1535 AKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGG 1594 KWDTLRAMGFDD HI DSR+L+FE+ F AT G+G+DVVL+SLAGEF +ASLRL+ GG Sbjct 1538 GKWDTLRAMGFDDDHIGDSRTLDFEDKFRSATGGAGMDVVLDSLAGEFVNASLRLVAPGG 1597 Query 1595 RFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVK 1654 F+E+GKTDIRD V + GVRYRAFDL E G R+ + E+ GL AGVL LPV Sbjct 1598 VFLEMGKTDIRDPGVVVREYPGVRYRAFDLFEPGRPRMHQWMVELAGLFDAGVLNPLPVT 1657 Query 1655 TFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLV 1714 TFD R AA R++SQARHIGKVV+T+P L+ GTV++TGGTGMAGS +A HLV Sbjct 1658 TFDIRRGRAALRYLSQARHIGKVVMTVP------GALSAGTVLITGGTGMAGSTLARHLV 1711 Query 1715 RRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYP 1774 HGV +L L+SR+G A AAE+ A L GA+V V++CD ADR ALA ++AG+ + P Sbjct 1712 TGHGVRDLALLSRTGPDAPGAAELVAELEAAGARVQVIACDAADRAALAGVIAGISAQRP 1771 Query 1775 LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIV 1834 L GV HAAGVLDDA+IT LTP+R+D VLRAKVD AWNLHELT DM+LSAFV+FSSMAG+V Sbjct 1772 LSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTRDMNLSAFVMFSSMAGLV 1831 Query 1835 GTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGL 1894 G+ QGNYAAAN+FLD L A+RR+ GL +S+AWGLW+QASAMT L D AR+ + G+ Sbjct 1832 GSSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGI 1891 Query 1895 APLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAA 1953 L++++A+ DTAL D + AR+D AL A+P +F++L PTRRR+ D+ Sbjct 1892 LALSSDEAMELFDTALIVDEPFLAPARIDLGALRAHAVAVPPMFAELVNAPTRRRVDDSL 1951 Query 1954 DTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLT 2013 A S S L RL L + L +LV S+ A VLG ++ I+ KAFQ+LGFDSLT Sbjct 1952 AAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLT 2011 Query 2014 AVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTA 2054 AVE+RNRLKTATGL LSPTLIFDYPTP LA ++ + L A Sbjct 2012 AVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELAGA 2052 Score = 1964 bits (5089), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1156/2096 (56%), Positives = 1411/2096 (68%), Gaps = 84/2096 (4%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + A +P+A+VGM CR+PGGVDSPE LW++VA G Sbjct 2037 TPNALAGYIRTELAGAPQEITHAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQMVAEG 2096 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFP DRGWD+AG+++PDPD G YTR GGF+ +VA FD FFGIAPSEALAMDP Sbjct 2097 RDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGIAPSEALAMDP 2156 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+ LE+SWEALERAGIDP+ LRGS TG+FAGV+ YG G P E + L G + S Sbjct 2157 QQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGYG-MGAAP-IAEGFRLTGQSSS 2214 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRV+YVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+ Sbjct 2215 VASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFV 2274 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R L+ DGRCKAYAGAADGT F+EG +LV+ RL+DARRLGH VLA+VRGSAVNQD Sbjct 2275 EFSRHRGLAPDGRCKAYAGAADGTGFSEGGAMLVVERLSDARRLGHSVLAVVRGSAVNQD 2334 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2335 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQ- 2393 Query 364 PADR--PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 DR PLWLGSIKSN+GHT AAAGVAGVIKMV AMRH +LP TLHVD P+PHVDWSAGA Sbjct 2394 --DRGQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGA 2451 Query 422 VSLLTEPRPWHVPG-RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPV--AVPW 478 VSLLTE +PW PG RPRRAGVSSFGISGTNAHVI+E PA EP AH + P +PW Sbjct 2452 VSLLTEAQPW--PGERPRRAGVSSFGISGTNAHVIIEAVPAAEP---AHADAPALPVLPW 2506 Query 479 VLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEG 538 ++SA+SA AL QA RL +V A + DVGW+L R+ F+HRAVVVG DR +L+ G Sbjct 2507 MVSAKSAAALRAQAARLAEYVRAHGELDIADVGWTLAG-RATFEHRAVVVGGDRDRLLAG 2565 Query 539 LTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERAL 598 L L+ P A ++ G A GKT FVFPGQG+Q LGMG QL A PVFAE L Sbjct 2566 LDELSTDDPAASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVFAEAFDAVVAEL 2625 Query 599 REHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEI 658 H+ L DV+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE+ Sbjct 2626 DRHLLRPLRDVIWG-DDENVLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGEL 2684 Query 659 AAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAV 718 +AA+VAG LSL++AA +VA R R + L G M+++ + Q L G + IAAV Sbjct 2685 SAAHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPL---LGPDVGIAAV 2741 Query 719 NGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPR 778 NG ++VV++G+ DA + +R AEG R R+ V +A HS ++ + +E G+ Sbjct 2742 NGPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLASD 2801 Query 779 TSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLI 838 + S +TG+ + EYW R +R V+F +VR A G F+E P L Sbjct 2802 KPVIPIISNLTGQPAADDFGSPEYWKRHVRDAVRFADSVRFAQSAGATRFLEVGPSSGLT 2861 Query 839 AGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSA-GQAHVAGVGVDWRAAFADLGG 897 A IEETL D P+V + R D ++A Q V G+ VDWR A G Sbjct 2862 AAIEETLADA-------PVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALGT--G 2912 Query 898 RRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISV 957 V+LPTYAF R+RFWL G GA D G+GL +H LL AVV+ P SGGV+LTGR+S Sbjct 2913 HLVDLPTYAFDRRRFWLSGDGA-ASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSS 2971 Query 958 VAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVV 1016 + WLADHAVG VVLFPG GFVELA+RAGDEVGC ++ EL L APLVLPA G V +QVV Sbjct 2972 ASQGWLADHAVGGVVLFPGAGFVELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVV 3031 Query 1017 VGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVA 1076 V G + SG R V V+S +AD+ GW LHA+GVL GS QPA +LS WPPVGA +D+ Sbjct 3032 VDGPDDSGARAVSVFS---RADAGAGWLLHAEGVLRAGSAQPATDLSAWPPVGAVPVDLG 3088 Query 1077 DGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHA 1134 DGY+ LA RGY YGPAFRGL ++WRRG E+FA+V LP GV GFG+HP +LDAALHA Sbjct 3089 DGYEQLAERGYRYGPAFRGLTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHA 3148 Query 1135 WGIV-EGEQ----QTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLS 1189 + +G++ ++PFSWQ V LHA+GAA VR R+ PV AVS+ELAD GLPVLS Sbjct 3149 VMLASDGDELPAGSMLVPFSWQRVSLHAAGAAAVRARIVPVSPSAVSIELADGLGLPVLS 3208 Query 1190 VRQLMVRPVSAAAL--SRSTAGDRGLLEMIWTPVP----------------LEGGDIGDD 1231 V ++ RPV+ L + S +G L E+IW+ P L+ D D Sbjct 3209 VASMVARPVTDQQLLAAVSNSGPDRLFELIWSAQPSTAVQPVSLLNWGATELDATDTDSD 3268 Query 1232 ----AVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPV 1287 AV++E P A GDV+ VY VL VLQ+WLA D G VV TRGA+ Sbjct 3269 SGRFAVLFESAPVA-----GDVVTEVYAATRAVLPVLQTWLARDGAGTLVVSTRGAMTLP 3323 Query 1288 DDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRV 1347 +DVTDLAGAAVWGLVRSAQ EHPGR+VLVDTD + + AV GEPQ ++R G V Sbjct 3324 REDVTDLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDAD-AVAAVLAVGEPQTLLRNGTV 3382 Query 1348 YAAR-LAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPV--APVELATGQVRVAVGAV 1404 Y AR L A G L G WRL GT+ ++ + P+ A L GQVRVA A+ Sbjct 3383 YTARVLGSRAVGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSAL 3442 Query 1405 GVNFRDVLVALGMYPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLL-GLVGSEAVVD 1462 NFRDV++ALG+YP +G++ +GVV+E +AVGDRVMGL G+ A+ D Sbjct 3443 AANFRDVMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTGTVAITD 3502 Query 1463 ARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLAR 1522 RL+ VPAGWS AA V F TA+Y L LA+ GQ+VLVHA GGVGMAAV LAR Sbjct 3503 QRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAVQLAR 3562 Query 1523 YWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEF 1582 ++G EVF TASR KWDTLR MGFDD H+ DSR L+FE+ F T G+G+D+VL+SL+G+ Sbjct 3563 HFGLEVFATASRGKWDTLRDMGFDDDHLGDSRGLDFEDKFRAVTGGAGMDIVLDSLSGDS 3622 Query 1583 TDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGL 1642 DASLRL+ GG F+E+GKTDIRD + VA H GVRYRAFDL EAGPDRIA +L E+ + Sbjct 3623 VDASLRLVAPGGIFLEMGKTDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAM 3682 Query 1643 LAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGT 1702 VL LPV FD R APAA R++SQARH+GKVV+T+PD GTV++TG T Sbjct 3683 FGEDVLRPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMPD------AWTAGTVLITGAT 3736 Query 1703 GMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDAL 1762 GMAGSAVA H+V RHG NLVLVSR G A AAE+ A L GA+ VV+CD ADR+AL Sbjct 3737 GMAGSAVARHVVTRHGARNLVLVSRRGLDAPGAAELVAELTAAGARAEVVACDAADREAL 3796 Query 1763 AALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLS 1822 A ++A + ++PL GV HAAGVL+DAV+T LTP R+DTVLRAKVD AWNLHELT D+D+ Sbjct 3797 AKVIADIPMQHPLTGVIHAAGVLEDAVVTSLTPQRIDTVLRAKVDAAWNLHELTRDLDVG 3856 Query 1823 AFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLG 1882 AFV+FSS+AG+ G QGNYAA N+FLDGL A+RR+ GL +S+ WGLW+QASAMT LG Sbjct 3857 AFVMFSSIAGLAGASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLG 3916 Query 1883 ERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQ 1940 D AR + G+ +++++AL +DTAL D ++ A +D AAL G LP +F Sbjct 3917 AADLARFGRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRAKFDGGTLPPMFVD 3976 Query 1941 LAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDIN 1999 L PTRR++ D+ A S S L+ RL L + +Q L DLV SN A VLG SS I+ Sbjct 3977 LINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIH 4036 Query 2000 AHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTAS 2055 +AFQ+LGFDSLTAVE+RNRLK ATGL LSPTLIFDYP A LA ++ LV S Sbjct 4037 PDRAFQELGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGTS 4092 >gi|118463709|ref|YP_881643.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118164996|gb|ABK65893.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=4171 Score = 2206 bits (5715), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1254/2080 (61%), Positives = 1502/2080 (73%), Gaps = 72/2080 (3%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA GRD +SE Sbjct 11 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEALWQMVAEGRDVISE 70 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+A L+DPDPDA K Y GGF+ +VA FD FFGIAPSEALAMDPQ R+LL Sbjct 71 FPTDRGWDLAALYDPDPDARHKCYVNTGGFVDNVADFDPAFFGIAPSEALAMDPQHRMLL 130 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ YG + ++E Y L G T SVASGRV Sbjct 131 ELSWEALERAGIDPSGLRGSATGVFAGLIVQGYG---MLAEEIEGYRLTGMTSSVASGRV 187 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 +YVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+EFSR R Sbjct 188 SYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRHR 247 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCKAYAGAADG ++EG +LV+ RL+DARRLGHPVLA+VRGSAVNQDGASNGL Sbjct 248 GLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVRGSAVNQDGASNGL 307 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADR-- 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ DR Sbjct 308 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQ---DRGQ 364 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGSIKSN+GHT AAAGVAGVIKMV AMRH +LP TLHVD P+PHVDWSAGAVSLLTE Sbjct 365 PLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTE 424 Query 428 PRPWHVPG-RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPV--AVPWVLSARS 484 +PW PG RPRRAGVSSFGISGTNAHVI+E PAVEP AH + P +PWV+SA+S Sbjct 425 AQPW--PGERPRRAGVSSFGISGTNAHVIIEAVPAVEP---AHADAPALPVLPWVVSAKS 479 Query 485 AQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAA 544 A AL QA RL +V A + DVGW+L R+ F+HRAVVVG DR +L+ GL LAA Sbjct 480 AAALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGGDRDRLLAGLDELAA 538 Query 545 GVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEW 604 P A ++ G A GKT FVFPGQG+QWLGM +L TAPVFA+HI CE A E V+W Sbjct 539 DDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFAQHIQACEEAFAEFVDW 598 Query 605 SLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVA 664 SL+D LRGAPGA G+DRVDVVQPAL+AVMVSLAELW+SVGV PDAVIGHSQGEIAAAYVA Sbjct 599 SLIDALRGAPGAAGMDRVDVVQPALFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVA 658 Query 665 GALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSV 724 GALSLRDAA VV LRS+LL L G GGM+S+AC +A +L + +G+R++IAAVNG S+V Sbjct 659 GALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAV 718 Query 725 VLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAF 784 V++GE A+ EL C +R RRIDVDYASHS +V+AIRE+L AL GIEPR+S +AF Sbjct 719 VVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPRSSRIAF 778 Query 785 FSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEET 844 FSTVTG +DTAG++A+YWYR+IRQ VQF++ VR+A + GYR F+ESSPHP L+AGIE+T Sbjct 779 FSTVTGNRLDTAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRTFIESSPHPALVAGIEDT 838 Query 845 LVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPT 904 + D G T E IVIPTLGRDDGG+ RF SA A VAGV V WR G VELPT Sbjct 839 VNDSLPGDT-EAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWRGVLD--GAGFVELPT 895 Query 905 YAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLA 964 YAF R+RFWL G GA D G+GL +EH LL+AVV+ P SGGVVLTGR+S WL Sbjct 896 YAFDRRRFWLSGEGA-AADASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLT 954 Query 965 DHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAD-----GVRVQVVVGG 1019 DHAV V+FPG GFVELA+RAGDEVGCS ++ELTLQAPL+LPA V VQV+VG Sbjct 955 DHAVSGTVVFPGAGFVELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGE 1014 Query 1020 VEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGY 1079 ++SG R+V ++S + DS W HAQG L GS++P A+L+ WPP GA +D+ADGY Sbjct 1015 ADESGRRDVSIFS---RPDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGATKVDIADGY 1071 Query 1080 QVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGV-PIRGFGIHPAVLDAALHAWGIV 1138 Q LAARGYGYGPAF+GL A W RG EVFA+V LP+ + GFG+HPA+LDAA+HA ++ Sbjct 1072 QRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTGFGVHPALLDAAMHA--LI 1129 Query 1139 EGEQ------QTMLPFSWQGVCLHASGAARVRVRLAP------VGRGAVSVELADPQGLP 1186 G Q + LPF+WQGV LHA+GA+ VR RLAP AVS+ELAD GLP Sbjct 1130 VGHQIAGDTDEVALPFAWQGVSLHAAGASAVRARLAPAQAPGTAASRAVSLELADGLGLP 1189 Query 1187 VLSVRQLMVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQ 1244 VLSVR ++ R VS L + S AG L E+ W PV + A E P H + Sbjct 1190 VLSVRAMVARSVSERQLRAAVSAAGPDRLFEVAWAPVTVP-------AAHGEPPVHQVFE 1242 Query 1245 ---AGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 A GD + YR HE L +QSWL +G+ VVVTRGA+ +DVTDL+GAAVWG Sbjct 1243 SLAAEGDPVGESYRRTHEALAAVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVWG 1302 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAA--GL 1359 LVRSAQ EHPGR+VL+D+D ++ + A+ +GEPQ+++R G VY AR+ A G+ Sbjct 1303 LVRSAQTEHPGRIVLIDSDAALD-DSALTAALATGEPQVLLRDGTVYTARVHGSRAVDGI 1361 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVAPVAPVE--LATGQVRVAVGAVGVNFRDVLVALGM 1417 P WRL GT ++ + PV + L GQVRVA+ A+ NFRDV++ LGM Sbjct 1362 MTPPEDR-PWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRDVMITLGM 1420 Query 1418 YPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSL 1475 + LG +GAGVVVEVGPGVT +VGD V G GS +V D RL+ P WS Sbjct 1421 FTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFP-DGSGTLVPGDVRLLQHKPTHWSY 1479 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 EAA + F TA+ LA+V GQ+VLVHA GGVGMAAV LAR+ G EVF TASR Sbjct 1480 PEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMAAVQLARHLGLEVFATASRG 1539 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HI DSR+LEFE+ F AT G+G+DVVL+SLAGEF DASLRL+ GG Sbjct 1540 KWDTLRAMGFDDDHIGDSRTLEFEDKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGV 1599 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD VA + GVRYRAFDL E G R+ + E+ GL AGVL LPV T Sbjct 1600 FLEMGKTDIRDPGVVAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTT 1659 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD R AA R++SQARHIGKVV+T+P L+ GTV++TGGTGMAGS +A HLV Sbjct 1660 FDIRRGRAALRYLSQARHIGKVVMTVP------GALSAGTVLITGGTGMAGSTLARHLVT 1713 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 HGV +L L+SR+G A AAE A L GA+V V++CD ADR ALA ++AG+ PL Sbjct 1714 GHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVIACDAADRAALAGVIAGISAERPL 1773 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV HAAGVLDDA+IT LTP+R+D VLRAKVD AWNLHELT DM+LSAFV+FSSMAG+VG Sbjct 1774 SGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTRDMNLSAFVMFSSMAGLVG 1833 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + QGNYAAAN+FLD L A+RR+ GL +S+AWGLW+QASAMT L D AR+ + G+ Sbjct 1834 SSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGIL 1893 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAAD 1954 L++++A+ DTAL D + AR+D AL A+P +F+ L PTRRR+ D+ Sbjct 1894 ALSSDEAMELFDTALIVDEPFLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDSLA 1953 Query 1955 TAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTA 2014 A S S L RL L + L +LV S+ A VLG ++ I+ KAFQ+LGFDSLTA Sbjct 1954 AAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTA 2013 Query 2015 VELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTA 2054 VE+RNRLKTATGL LSPTLIFDYPTP LA ++ + L A Sbjct 2014 VEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELAGA 2053 Score = 1972 bits (5108), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1165/2096 (56%), Positives = 1411/2096 (68%), Gaps = 84/2096 (4%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + A +P+A+VGM CR+PGGVDSPE LW++VA G Sbjct 2038 TPNALAGYIRTELAGAPQETTHAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQMVAEG 2097 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFP DRGWD+AG+++PDPD G YTR GGF+ +VA FD FFGIAPSEALAMDP Sbjct 2098 RDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGIAPSEALAMDP 2157 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+ LE+SWEALERAGIDP+ LRGS TG+FAGV+ YG G P E + L G + S Sbjct 2158 QQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGYG-MGAAP-IAEGFRLTGQSSS 2215 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRV+YVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GGVTV ATP +F+ Sbjct 2216 VASGRVSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTVNATPDIFV 2275 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKAYAGAADGT F+EG G+LV+ RL+DARRLGHPVLA+VRGSAVNQD Sbjct 2276 EFSRMRGLSVDGRCKAYAGAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQD 2335 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2336 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQ- 2394 Query 364 PADR--PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 DR PLWLGSIKSN+GHT AAAGVAGVIKMV AMRH +LP TLHVD P+PHVDWSAGA Sbjct 2395 --DRGQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGA 2452 Query 422 VSLLTEPRPWHVPG-RPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPV--AVPW 478 VSLLTE +PW PG RPRRAGVSSFGISGTNAHVI+E PAVEP AH + P +PW Sbjct 2453 VSLLTEAQPW--PGERPRRAGVSSFGISGTNAHVIIEAVPAVEP---AHADAPALPVLPW 2507 Query 479 VLSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEG 538 V+SA+SA AL QA RL +V A + DVGW+L R+ F+HRAVVVG DR +L+ G Sbjct 2508 VVSAKSAAALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGGDRDRLLAG 2566 Query 539 LTGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERAL 598 L LAA P A ++ G A GKT FVFPGQG+Q LGMG QL A PVFAE L Sbjct 2567 LDELAADDPAASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVFAEAFDAVVAEL 2626 Query 599 REHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEI 658 H+ L DV+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE+ Sbjct 2627 DRHLLRPLRDVIWG-DDENVLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGEL 2685 Query 659 AAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAV 718 +AA+VAG LSL++AA +VA R R + L G M+++ + Q L G + IAAV Sbjct 2686 SAAHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPL---LGPDVGIAAV 2742 Query 719 NGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPR 778 NG ++VV++G+ DA + +R AEG R R+ V +A HS ++ + +E G+ Sbjct 2743 NGPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLAID 2802 Query 779 TSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLI 838 + S +TG+ + EYW +R V+F +VR A G F+E P L Sbjct 2803 KPVIPIISNLTGQPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFLEVGPSSGLT 2862 Query 839 AGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSA-GQAHVAGVGVDWRAAFADLGG 897 A IEETL D P+V + R D ++A Q V G+ VDWR A G Sbjct 2863 AAIEETLADA-------PVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALGT--G 2913 Query 898 RRVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISV 957 V+LPTYAF R+RFWL G GA D G+GL +H LL AVV+ P SGGV+LTGR+S Sbjct 2914 HLVDLPTYAFDRRRFWLSGDGA-ASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSP 2972 Query 958 VAAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVV 1016 + WLADHAVG VVLFPG GFVELA+RAGDEVGC ++ EL L APLVLPA G V +QVV Sbjct 2973 ASQGWLADHAVGGVVLFPGAGFVELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVV 3032 Query 1017 VGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVA 1076 V G + SG R V V+S +AD+ GW LHA+GVL GS QPA +LS WPPVGA +D+ Sbjct 3033 VDGPDDSGARAVSVFS---RADAGAGWLLHAEGVLRAGSAQPATDLSAWPPVGAVPVDLG 3089 Query 1077 DGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHA 1134 DGY+ LA RGY YGPAFRGL ++WRRG E+FA+V LP GV GFG+HP +LDAALHA Sbjct 3090 DGYEQLAERGYRYGPAFRGLTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHA 3149 Query 1135 WGIV-EGEQ----QTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLS 1189 + +G+ ++PFSWQ V LHA+GAA VR R+ PV AVS+ELAD GLPVLS Sbjct 3150 VMLASDGDDLPAGSMLVPFSWQRVSLHAAGAAAVRARIVPVSPSAVSIELADGLGLPVLS 3209 Query 1190 VRQLMVRPVSAAAL--SRSTAGDRGLLEMIWTPVP----------------LEGGDIGDD 1231 V ++ RPV+ L + S +G L E+IW+ P L+ D D Sbjct 3210 VASMVARPVTDQQLLAAVSNSGPDRLFELIWSAQPSTAVQPVSLLNWGATELDATDTDSD 3269 Query 1232 ----AVVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPV 1287 AV++E P A GDV+ VY VL VLQSWLA D G VV TRGA+ Sbjct 3270 SGRFAVLFESAPVA-----GDVVTEVYAATRAVLPVLQSWLARDGAGTLVVSTRGAMTLP 3324 Query 1288 DDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRV 1347 +DVTDLAGAAVWGLVRSAQ EHPGR+VLVDTD + + AV GEPQ ++R G V Sbjct 3325 GEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDAD-AVAAVLAVGEPQTLLRNGTV 3383 Query 1348 YAAR-LAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPV--APVELATGQVRVAVGAV 1404 Y AR L A G L G WRL GT+ ++ + P+ A L GQVRVA A+ Sbjct 3384 YTARVLGSRAVGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSAL 3443 Query 1405 GVNFRDVLVALGMYPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLL-GLVGSEAVVD 1462 NFRDV++ALG+YP +G++ +GVV+E +AVGDRVMGL G+ A D Sbjct 3444 AANFRDVMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTGTVATTD 3503 Query 1463 ARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLAR 1522 RL+ VPAGWS AA V F TA+Y L LA+ GQ+VLVHA GGVGMAAV LAR Sbjct 3504 QRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAVQLAR 3563 Query 1523 YWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEF 1582 + G EVF TASR KWDTLR MGFDD H+ DSR L+FE+ F T G+G+D+VL+SL+G+ Sbjct 3564 HLGLEVFATASRGKWDTLRDMGFDDDHLGDSRGLDFEDKFRAVTGGAGMDIVLDSLSGDS 3623 Query 1583 TDASLRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGL 1642 DASLRL+ GG F+E+GKTDIRD + VA H GVRYRAFDL EAGPDRIA +L E+ + Sbjct 3624 VDASLRLVAPGGIFLEMGKTDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAM 3683 Query 1643 LAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGT 1702 VL LPV FD R APAA R++SQARH+GKVV+T+PD GTV++TG T Sbjct 3684 FGEDVLRPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMPD------AWTAGTVLITGAT 3737 Query 1703 GMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDAL 1762 GMAGSAVA H+V RHG NLVLVSR G A AAE+ A L GA VV+CD ADR+AL Sbjct 3738 GMAGSAVARHVVTRHGARNLVLVSRRGLDAPDAAELVAELTAAGAHAEVVACDAADREAL 3797 Query 1763 AALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLS 1822 A ++A + ++PL GV HAAGVLDDAV+T LTP R+DTVLRAKVD AWNLHELT D+D+ Sbjct 3798 AKVIADIPMQHPLTGVIHAAGVLDDAVVTSLTPQRIDTVLRAKVDAAWNLHELTRDLDVG 3857 Query 1823 AFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLG 1882 AFV+FSS+AG+ G QGNYAA N+FLDGL A+RR+ GL +S+ WGLW+QASAMT LG Sbjct 3858 AFVMFSSIAGLAGASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLG 3917 Query 1883 ERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAAL--AGAGAALPALFSQ 1940 D AR + G+ +++++AL +DTAL D ++ A +D AAL G LP +F Sbjct 3918 AADLARFGRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVD 3977 Query 1941 LAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDIN 1999 L PTRR++ D+ A S S L+ RL L + +Q L DLV SN A VLG SS I+ Sbjct 3978 LINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIH 4037 Query 2000 AHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTAS 2055 +AFQ+LGFDSLTAVE+RNRLK ATGL LSPTLIFDYP A LA ++ LV S Sbjct 4038 PDRAFQELGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGTS 4093 >gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|298495345|gb|EFI30639.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=4151 Score = 2201 bits (5704), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1257/2056 (62%), Positives = 1487/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ DVA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDDVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 2003 bits (5188), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1166/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycobacterium tuberculosis 210] Length=4151 Score = 2199 bits (5697), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1256/2056 (62%), Positives = 1486/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 2002 bits (5186), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1165/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV V++CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVLACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|289762206|ref|ZP_06521584.1| predicted protein [Mycobacterium tuberculosis GM 1503] gi|289709712|gb|EFD73728.1| predicted protein [Mycobacterium tuberculosis GM 1503] Length=2191 Score = 2196 bits (5690), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1256/2056 (62%), Positives = 1486/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 206 bits (524), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 94/160 (59%), Positives = 116/160 (73%), Gaps = 0/160 (0%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYG 163 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG 2185 >gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|253320398|gb|ACT25001.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|328458652|gb|AEB04075.1| polyketide synthase pks12 [Mycobacterium tuberculosis KZN 4207] gi|344219874|gb|AEN00505.1| polyketide synthase pks12 [Mycobacterium tuberculosis CTRI-2] Length=4152 Score = 2194 bits (5685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1254/2056 (61%), Positives = 1482/2056 (73%), Gaps = 40/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPDA G YTR GGF+ V FD FFG+ PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSSVASGRV 187 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 188 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 247 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 248 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 307 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 308 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 367 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 368 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 427 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 428 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 485 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 486 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 544 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 545 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 604 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 605 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 664 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 665 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 724 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 725 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 784 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 785 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 844 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 845 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 901 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 902 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 960 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 961 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1020 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1021 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1077 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1078 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1137 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1138 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1197 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1198 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1251 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1252 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1311 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1312 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1370 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1371 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1430 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1431 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1489 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1490 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1549 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1550 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1609 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD RCAPAA R++SQARH GK Sbjct 1610 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGK 1669 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1670 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1723 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1724 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1783 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1784 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1843 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1844 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1903 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1904 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1963 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1964 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2023 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2024 DYPTPNRLASYIRTEL 2039 Score = 2003 bits (5188), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1166/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2027 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2086 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2087 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2146 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2147 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2204 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2205 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2264 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2265 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2324 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2325 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2384 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2385 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2444 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2445 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2502 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2503 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2561 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2562 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2621 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2622 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2680 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2681 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2737 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2738 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2797 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2798 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2857 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2858 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2909 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2910 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2968 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2969 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3028 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3029 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3085 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3086 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3145 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3146 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3205 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3206 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3265 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3266 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3320 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3321 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3379 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3380 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3438 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3439 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3498 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3499 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3558 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3559 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3618 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3619 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3678 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3679 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3732 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3733 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3792 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3793 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3852 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3853 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3912 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3913 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3972 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3973 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4032 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4033 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4083 >gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289574727|ref|ZP_06454954.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339632088|ref|YP_004723730.1| polyketide synthase [Mycobacterium africanum GM041182] gi|124601277|gb|EAY60287.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289539158|gb|EFD43736.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339331444|emb|CCC27133.1| putative polyketide synthase pks12 [Mycobacterium africanum GM041182] Length=4151 Score = 2194 bits (5684), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1255/2056 (62%), Positives = 1485/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 2003 bits (5189), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1166/2091 (56%), Positives = 1414/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] gi|289420626|gb|EFD17827.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] Length=4151 Score = 2193 bits (5683), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1255/2056 (62%), Positives = 1485/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 2001 bits (5185), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1166/2091 (56%), Positives = 1413/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWYLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|13881781|gb|AAK46387.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] Length=4151 Score = 2193 bits (5683), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1255/2056 (62%), Positives = 1485/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 1999 bits (5178), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1163/2091 (56%), Positives = 1412/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL EAGPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] gi|2896785|emb|CAA17262.1| Probable polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] Length=4151 Score = 2193 bits (5683), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1255/2056 (62%), Positives = 1485/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 1996 bits (5172), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1163/2091 (56%), Positives = 1411/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 Q R+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ E TL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL E GPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|342859764|ref|ZP_08716417.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342132896|gb|EGT86116.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=4176 Score = 2191 bits (5677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1255/2072 (61%), Positives = 1499/2072 (73%), Gaps = 57/2072 (2%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 +ALR++L Q ERLKR NR LL R+ EP+A+VGM CR+PGGVDSPE LW++VA GRD +S Sbjct 9 TEALRKALVQVERLKRTNRALLERSNEPIAIVGMSCRFPGGVDSPEALWQMVADGRDVIS 68 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 EFPADRGWDVA L+DPDPDA K Y GGF+ VA FD FFGIAPSEALAMDPQ R+L Sbjct 69 EFPADRGWDVASLYDPDPDARHKCYVNTGGFVDGVADFDPAFFGIAPSEALAMDPQHRML 128 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LE+SWEALERAGIDP LRGS TGVFAG+ YG + ++E Y L G T SVASGR Sbjct 129 LELSWEALERAGIDPSGLRGSATGVFAGLIVQGYG---MLAEEIEGYRLTGMTSSVASGR 185 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 V+YVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+EFSR Sbjct 186 VSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRH 245 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 R L+ DGRCKAYAGAADG ++EG +LV+ RL+DA+RLGHPVLA+VRGSAVNQDGASNG Sbjct 246 RGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLAVVRGSAVNQDGASNG 305 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRP 368 L PNGP+QQRV+ AALA+A L VADVDVVEGHGTGTTLGDPIEAQA+LATYGQ ++ P Sbjct 306 LTAPNGPSQQRVVRAALANAGLSVADVDVVEGHGTGTTLGDPIEAQALLATYGQDRSE-P 364 Query 369 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEP 428 LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH LP TLHVD P+PHVDWSAGAVSLLTE Sbjct 365 LWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHETLPATLHVDAPSPHVDWSAGAVSLLTEA 424 Query 429 RPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQAL 488 RPW+V RPRRAGVSSFGISGTNAHVI+E APA +P A PV VPW +SA+S AL Sbjct 425 RPWNVE-RPRRAGVSSFGISGTNAHVIVEAAPA-QPEREAGPARPV-VPWAVSAKSPSAL 481 Query 489 TNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPG 548 QA RL +V A ++ D+GWSL R+ F+HRAVV+GADR +L+ GL LA P Sbjct 482 AAQAARLAEYVRAHRDLDVADIGWSLAG-RAAFEHRAVVIGADRDRLLAGLDELANDDPT 540 Query 549 ADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLD 608 V+ G A GKT FVFPGQG+QW GM +L APVFA+ I CE A E V+WSL Sbjct 541 GSVIRGVATPSGKTVFVFPGQGSQWAGMAVELLDAAPVFAQQIRECEEAFAEFVDWSLTG 600 Query 609 VLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALS 668 VLRGAP APGLDRVDVVQP L+AVMVSLAELW+SVGV PDAVIGHSQGEIAAAYVAGALS Sbjct 601 VLRGAPDAPGLDRVDVVQPVLFAVMVSLAELWKSVGVNPDAVIGHSQGEIAAAYVAGALS 660 Query 669 LRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLAG 728 LRDAA VV LRS+LL L G GGM+S+AC +A +L + +G+R++IAAVNG S+VV++G Sbjct 661 LRDAARVVTLRSKLLTALAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSG 720 Query 729 ETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTV 788 E A+ EL+ C +R RRIDVDYASHS +V+AIR +L L GIEPR+S +AFFSTV Sbjct 721 EGAALDELVGFCADLELRTRRIDVDYASHSVEVEAIRADLAEVLSGIEPRSSRIAFFSTV 780 Query 789 TGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD- 847 TG +DTAG++A+YWYR+IRQ VQF++AVR+A + GYR F+ESSPHP LIAGIE+T D Sbjct 781 TGSRLDTAGLDADYWYRNIRQTVQFDQAVRSACEHGYRTFIESSPHPALIAGIEDTADDH 840 Query 848 CDRGATG-EPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYA 906 GA G E VIPTLGRDDGG+ RF SA A VAGV V WR A G VELPTYA Sbjct 841 VGGGADGAEVTVIPTLGRDDGGLDRFLTSAAAAFVAGVSVRWRGALD--GAAFVELPTYA 898 Query 907 FARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADH 966 F R+RFWL G G V D G+GL +EH LL+AVV+ P SGGVVLTGR+S WL+DH Sbjct 899 FDRRRFWLSGEG-VAADASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSPSRQGWLSDH 957 Query 967 AVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAD-----GVRVQVVVGGVE 1021 AV +FPG+GFVELA+RAGDEVGCS + ELTLQAPL+LPA V VQVVVG VE Sbjct 958 AVSGTAVFPGSGFVELAIRAGDEVGCSTVDELTLQAPLMLPAKDSGSASVAVQVVVGPVE 1017 Query 1022 QSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQV 1081 +SG R V ++S + D+ GW +A+G L GSV+P AELS WPP GA +D ADGY+ Sbjct 1018 ESGQRGVSIFS---RPDAGSGWVCNAEGTLSTGSVEPGAELSAWPPAGAVKVDAADGYEQ 1074 Query 1082 LAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGV-PIRGFGIHPAVLDAALHAW----G 1136 LAARGYGYGPAF+GL A W R EVFA+V LP+ + GFG+HPA+LDAA+HA Sbjct 1075 LAARGYGYGPAFQGLTAAWVRDDEVFAEVRLPDAAGGVNGFGVHPALLDAAMHALIVGRH 1134 Query 1137 IVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVR 1196 I + +LPFSWQGV LHA+GA+ VR R+AP G +VS+ELAD GLPVLSVR ++ R Sbjct 1135 ITGQTDEVVLPFSWQGVSLHAAGASAVRARIAPAGPSSVSIELADGLGLPVLSVRAMVAR 1194 Query 1197 PVSAAAL--SRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPH---AGAQAGGDVLA 1251 PVS L + S +G L E+ W+P V E P H AG D ++ Sbjct 1195 PVSERQLRAAVSASGPDRLFELAWSPA-------ATSTVGAEPPAHEVFESVAAGEDPVS 1247 Query 1252 AVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHP 1311 Y H L +QSWL +G+ +V TR A+G +D+TDLAGAAVWGLVRSAQ EHP Sbjct 1248 GSYERTHRALAAVQSWLTDRDSGVLIVATRHAMGLAGEDITDLAGAAVWGLVRSAQTEHP 1307 Query 1312 GRVVLVDTDGSVAVED-AVGFGARSGEPQLVVRRGRVYAARLAPVAA--GLTLPSASAGG 1368 GR+VLVD+D A++D A+ GEP +++R G Y AR+ A G+ P A G Sbjct 1308 GRIVLVDSD--TALDDHAIATVLAVGEPAVLLRDGTAYIARVHGSRAVDGIMTPPAD-GP 1364 Query 1369 WRLVAGGGGTLADVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGV 1426 WRL GT ++ + PV A L GQVRVA+ A+ NFRDV++ LGM+ LG Sbjct 1365 WRLGISSAGTFENLQLEPVPNAGAALEPGQVRVAMRAIATNFRDVMITLGMFTHEALLGG 1424 Query 1427 DGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVA 1484 +GAGVVVEVGPGVT AVGD V G GS +V D RL+ PA WS EAA + Sbjct 1425 EGAGVVVEVGPGVTEFAVGDSVYGFFP-DGSGTLVPGDVRLLQHKPAHWSYAEAAGISAV 1483 Query 1485 FLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMG 1544 F TA+ LA+V GQ+VLVHA GGVGMAAV L R+ G EVF TASR KWDTLRAMG Sbjct 1484 FTTAYMAFIHLADVKPGQRVLVHAAAGGVGMAAVQLGRHLGLEVFATASRGKWDTLRAMG 1543 Query 1545 FDDIHISDSRSLEFEEAFLRATEG----SGVDVVLNSLAGEFTDASLRLLPSGGRFIELG 1600 FDD HI+DSR+LEFEE F RA G +G+DVVL+SLAGEF DASLRL+ GG F+E+G Sbjct 1544 FDDDHIADSRTLEFEEKF-RAVTGRTGTAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMG 1602 Query 1601 KTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARC 1660 KTDIRD VA+ + GVRYRAFDL E G R+ + E+ GL AGVL LPV TFD R Sbjct 1603 KTDIRDPGAVAQEYPGVRYRAFDLFEPGRPRMHQWMQELAGLFDAGVLEPLPVTTFDVRR 1662 Query 1661 APAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVA 1720 A A R++SQARHIGKVV+T+P GPG +GL+ GTV++TGGTGMAGS +A HLV HGV Sbjct 1663 ARTALRYLSQARHIGKVVMTVPSGPG--AGLSAGTVLITGGTGMAGSTLARHLVAHHGVE 1720 Query 1721 NLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFH 1780 +LVL+SR G A +AE+ A L GA+ VV+CD ADR ALA ++ G+ R PL GV H Sbjct 1721 DLVLLSRRGPDAPGSAELIAELESAGARARVVACDAADRAALAQVIDGISARRPLSGVIH 1780 Query 1781 AAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQG 1840 A GVLDDA++T LTPDR+D VLRAKVD AWNLHELT +++LSAFV+FSSMAG+VG+ QG Sbjct 1781 ATGVLDDAMVTSLTPDRIDAVLRAKVDAAWNLHELTRELNLSAFVMFSSMAGLVGSSGQG 1840 Query 1841 NYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTE 1900 NYAAAN+FLDGL A+RR+ GL +S+AWGLW+QASAMT L D AR+ + G+ L+++ Sbjct 1841 NYAAANSFLDGLAAHRRAHGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGILALSSD 1900 Query 1901 QALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSM 1959 +A+ DTAL D A + AR+D AL A+P +F+ L PTRRR+ D+ A S Sbjct 1901 EAMDLFDTALIVDEAFLAPARIDLGALRAHAVAVPPMFTDLVNAPTRRRVDDSLAAAKSK 1960 Query 1960 SGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRN 2019 S L RL L+ + L DLV S+ A VLG +++ I+ KAFQ+LGFDSLTAVE+RN Sbjct 1961 SALAHRLDGLSEAEQHAVLLDLVRSHIATVLGNTTAEAIDPDKAFQELGFDSLTAVEMRN 2020 Query 2020 RLKTATGLTLSPTLIFDYPTPATLAEHLDSRL 2051 RLKTATGL LSPTLIFDYPTP LA ++ ++L Sbjct 2021 RLKTATGLALSPTLIFDYPTPNGLAGYIRTQL 2052 Score = 1929 bits (4996), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1145/2092 (55%), Positives = 1392/2092 (67%), Gaps = 70/2092 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + A +P+ +VGM CRYPGGV SP+ LW+++ G Sbjct 2040 TPNGLAGYIRTQLAGVPQEIKHAPVARATGDDPIVIVGMACRYPGGVSSPDDLWDMLTEG 2099 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFP DRGWD+AG+++PDPD G YTR GGF+ VA FD FFGIAPSEAL+MDP Sbjct 2100 RDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDGVADFDPAFFGIAPSEALSMDP 2159 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 QQR+ LE+SWEALERAGIDP LRGS TG+FAGV+ YG G P E + L G + S Sbjct 2160 QQRMFLELSWEALERAGIDPGKLRGSATGMFAGVYTQGYG-MGAAP-TAEGFRLTGQSSS 2217 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRV+YVLGL+GPAVSVDTACSSSLVALH+A QSLR GECDLAL GGVTV ATP +F+ Sbjct 2218 VASGRVSYVLGLEGPAVSVDTACSSSLVALHMAAQSLRSGECDLALAGGVTVNATPDIFV 2277 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKAYAGAADGT F+EG G+LV+ RL+DA+RLGHPVLA+VRGSA+NQD Sbjct 2278 EFSRMRGLSEDGRCKAYAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLAMVRGSAINQD 2337 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2338 GASNGLTAPNGPSQQRVVRAALANAGLTPAEVDVVEGHGTGTTLGDPIEAQALLATYGQ- 2396 Query 364 PADR--PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 DR PLWLGSIKSN+GHT AAAGVAGVIKMV AMRH +LP TLHVD P+PHVDWS G+ Sbjct 2397 --DRGEPLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHEILPATLHVDEPSPHVDWSTGS 2454 Query 422 VSLLTEPRPWHVP--GRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWV 479 VSLLT+ R W RPRRAGVSSFGISGTNAHVI+E PA +P PV VPW Sbjct 2455 VSLLTQARDWKPKPDDRPRRAGVSSFGISGTNAHVIIEAVPAGQPRVVDGPAAPV-VPWP 2513 Query 480 LSARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGL 539 +SA+S ALT+QA RL A + A ++ DVGWSL RS F+ RAVVVG DR L+ GL Sbjct 2514 VSAKSLSALTSQATRLAAHLRAHPDLDIADVGWSLAG-RSAFEQRAVVVGGDRDGLLAGL 2572 Query 540 TGLAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALR 599 LA G ++ G A T GKTAFVFPGQG+Q LGMG L A PVFAE L Sbjct 2573 EELAGDNLGGSIIQGTA-TAGKTAFVFPGQGSQTLGMGRGLHAGYPVFAEAFDTVVAELD 2631 Query 600 EHVEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIA 659 +H+ L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE+A Sbjct 2632 QHLLRPLREVMWG-DDETLLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELA 2690 Query 660 AAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEK-LASQWGDRLNIAAV 718 AA+VAG LSL++AA +VA R R + L G MV++ + + L + IAAV Sbjct 2691 AAHVAGVLSLQNAAVLVAARGRFMQALPEGGAMVAVQATEDEVRALLVGSDQASVGIAAV 2750 Query 719 NGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPR 778 NG +SVV++G +AV + R A+G R R+ V +A HS +D + +E G+ Sbjct 2751 NGPTSVVISGAHEAVAAVADRLRADGHRVHRLSVSHAFHSPLMDPMIDEFGTVAAGLTVG 2810 Query 779 TSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLI 838 + S VTG+L + YW R +R+ V+F +VR G F+E P L Sbjct 2811 KPAIPIVSNVTGQLAGDDYASVAYWKRHVREAVRFADSVRFVHSAGANRFLEVGPGSGLT 2870 Query 839 AGIEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGR 898 A IEE+L A+ + L +D + Q +VAG+ VDWR A + G Sbjct 2871 ASIEESLAADPMAAS--VTTMSALRKDRPEPLSLVNAVAQGYVAGMDVDWRGALGE--GN 2926 Query 899 RVELPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVV 958 VELPTYAF R+RFWL D G+GL EH LL AVV+ P SGGVVLTGR+S Sbjct 2927 LVELPTYAFDRRRFWL-AADGAPADAAGLGLAAGEHALLGAVVELPASGGVVLTGRLSPG 2985 Query 959 AAPWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVV 1017 WLADHAVG VVLFPG GFVELA+RAGDEVGC V++EL L APLVLPA G V VQVVV Sbjct 2986 TQGWLADHAVGGVVLFPGAGFVELAIRAGDEVGCGVVEELNLAAPLVLPAGGSVAVQVVV 3045 Query 1018 GGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVAD 1077 GG + SG+R V V+S +A++ GW+LHA+G L GSVQP+A+LS WPPVGA +DV D Sbjct 3046 GGPDDSGSRAVSVFS---RAEAGSGWSLHAEGALRAGSVQPSADLSAWPPVGAVPVDVGD 3102 Query 1078 GYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPE--GVPIRGFGIHPAVLDAALHAW 1135 GY+ LA RGY YGPAFRGL ++WRRG EVFA+V+LP GV GFG+HPA+LDAALHA Sbjct 3103 GYEQLAERGYAYGPAFRGLTSMWRRGDEVFAEVSLPTDAGVSPAGFGVHPAMLDAALHAV 3162 Query 1136 GIVEG-----EQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSV 1190 + E ++PFSWQ V LHA+GA VR R+ PV VS+ELAD GLPVLSV Sbjct 3163 MLASDSDELPEGSMLVPFSWQQVSLHAAGAGAVRARIVPVSPSTVSIELADGLGLPVLSV 3222 Query 1191 RQLMVRPVSAAAL--SRSTAGDRGLLEMIWTPVP----------------LEGGDIGDDA 1232 ++ RPV+ L + S +G L E+IW+ P L+G A Sbjct 3223 ASMVARPVTDKQLLAAVSNSGPDRLFEVIWSAQPSAAVQPVSLSAWGTAELDGTGAERSA 3282 Query 1233 VVWELPPHAGAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVT 1292 V++E P GDV+ VY VL VLQSWL+ D VV TRGA+ +DVT Sbjct 3283 VLFESQP-----VSGDVITEVYAATRAVLPVLQSWLSRDDAATLVVATRGAMTLPGEDVT 3337 Query 1293 DLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL 1352 DLAGAAVWGLVRSAQ EHPGR+VLVDTD + + AV EPQ ++R G VY AR+ Sbjct 3338 DLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDAD-AVAAVLALAEPQAILRNGTVYTARV 3396 Query 1353 --APVAAGLTLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNF 1408 + GL LP G WRL GT+ ++ + P A L GQVRVA+ A+ NF Sbjct 3397 LGSRAVGGLLLPP-DDGPWRLGMSSYGTIENLRIERIPDADAPLGHGQVRVALSAIAANF 3455 Query 1409 RDVLVALGMYPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLL-GLVGSEAVVDARLV 1466 RDV++ALG+YP +G++ +GVV+E AVGDRVMGL G+ A D RL+ Sbjct 3456 RDVMIALGLYPDPEAIMGIEASGVVIETASPDGRFAVGDRVMGLFPDGTGTIAKTDQRLL 3515 Query 1467 TMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGA 1526 VPAGWS AA V F TA Y L LA GQ+VLVHA GGVGMAAV LAR+ G Sbjct 3516 VKVPAGWSHTAAATASVVFATANYALVDLAGAKPGQRVLVHAAAGGVGMAAVQLARHIGL 3575 Query 1527 EVFVTASRAKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDAS 1586 EVF TASR KWDTLR MGFDD HI+DSRSL FE+ F T G G+D+VL+SL+G+F DAS Sbjct 3576 EVFATASRGKWDTLREMGFDDDHIADSRSLGFEDKFRAVTAGRGMDIVLDSLSGDFVDAS 3635 Query 1587 LRLLPSGGRFIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAG 1646 LRL GG F+E+GKTDIRD + VA H GVRYRAFDL EAGPDRIA ML E+ + Sbjct 3636 LRLTAPGGVFLEMGKTDIRDPEVVAREHAGVRYRAFDLFEAGPDRIAQMLDELAAMFGED 3695 Query 1647 VLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAG 1706 VL LPV FD R APAA R++SQARH+GKVV+T+PD GTV++TG TGMAG Sbjct 3696 VLRPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMPD------AWTAGTVLITGATGMAG 3749 Query 1707 SAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALL 1766 SAVA H+V RHG NLVLVSR G A AAE+ A L GA V V+CD ADR+ALA ++ Sbjct 3750 SAVARHVVSRHGARNLVLVSRRGLDAPGAAELVAELSAAGAHVEAVACDAADREALAKVI 3809 Query 1767 AGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVV 1826 A + ++PL GV HAAGVL DAV+T LTPDR+++VLR+KVD AWNLHELT ++D+SAFV+ Sbjct 3810 AEIPMQHPLTGVIHAAGVLHDAVVTSLTPDRIESVLRSKVDAAWNLHELTRELDVSAFVM 3869 Query 1827 FSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDR 1886 FSS+AG+ G Q NYAA N+FLDGL A+RR+ GL +S+ WGLW+QASAMT LG DR Sbjct 3870 FSSIAGLAGASGQANYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADR 3929 Query 1887 ARMTQAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAAL--AGAGAALPALFSQLAAG 1944 AR + G+ ++++QAL +DTAL D ++ A +D AAL G LP +F L Sbjct 3930 ARFGRDGIVAMSSDQALELMDTALIVDEPFMLPAHIDLAALRVKFDGGTLPPMFVDLINA 3989 Query 1945 PTRRRI-DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKA 2003 PTRR++ D+ A S S L+ RL L + +Q L DLV +N A VLG +S I+ +A Sbjct 3990 PTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAILLDLVRANIATVLGSASPEAIHPDRA 4049 Query 2004 FQDLGFDSLTAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTAS 2055 FQ+LGFDSLTAVE+RNRLK ATGL LSPTLIFDYP A LA ++ LV +S Sbjct 4050 FQELGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGSS 4101 >gi|254822171|ref|ZP_05227172.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=4177 Score = 2190 bits (5675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1246/2074 (61%), Positives = 1495/2074 (73%), Gaps = 57/2074 (2%) Query 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE+LW++VA GRD +S Sbjct 9 TEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPESLWQMVADGRDVIS 68 Query 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 EFPADRGWD+ L+DPDPDA K Y GGF+ VA FD FFGIAPSEALAMDPQ R+L Sbjct 69 EFPADRGWDLGALYDPDPDARHKCYVNAGGFVDGVADFDPAFFGIAPSEALAMDPQHRML 128 Query 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 LE+SWEALERAGIDP LRGS TGVFAG+ YG + ++E Y L G T SVASGR Sbjct 129 LELSWEALERAGIDPSGLRGSATGVFAGLIVQGYG---MLAEEIEGYRLTGMTSSVASGR 185 Query 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 V+YVLGL+GPAVSVDTACSSSLVALH+AVQSLR GECDLAL GG TV ATP +F+EFSR Sbjct 186 VSYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRH 245 Query 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 R L+ DGRCKAYAGAADG ++EG +LV+ RL+DA+RLGHPVLA+VRGSAVNQDGASNG Sbjct 246 RGLAPDGRCKAYAGAADGVGWSEGGAILVVERLSDAQRLGHPVLAVVRGSAVNQDGASNG 305 Query 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RPADR 367 L PNGP+QQRV+ AALA+A L ++VDVVEGHGTGTTLGDPIEAQA+LATYGQ R Sbjct 306 LTAPNGPSQQRVVRAALANAGLAASEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGPSG 365 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGSIKSN+GHT AAAGVAGVIKMVQAMRH LP TLHVD P+PHVDWSAGAVSLLTE Sbjct 366 PLWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHETLPATLHVDEPSPHVDWSAGAVSLLTE 425 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 +PW RPRRAGVSSFGISGTNAHVI+E APA E V + VPW LSA+SA+A Sbjct 426 AQPWGA-DRPRRAGVSSFGISGTNAHVIIEAAPA-ETVEVTERPEVPVVPWALSAKSARA 483 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL ++ A + DVGW+L R+ F+HRAV+V DR +L+ GL LA P Sbjct 484 LAAQAARLAEYLRAHHELDVADVGWTLAG-RATFEHRAVIVADDRDRLLAGLDELANDDP 542 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 V+ G A GKT FVFPGQG+QWLGMG +L TAPVFA+ I CE A E V+WSL+ Sbjct 543 TGTVLRGIATPAGKTVFVFPGQGSQWLGMGIELLDTAPVFAQQIQACEEAFAEFVDWSLI 602 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPG+DRVDVVQP L+AVMVSLAELW+SVGV PDAVIGHSQGEIAAAYVAGAL Sbjct 603 DVLRGAPGAPGMDRVDVVQPVLFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGAL 662 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDA VV LRS+LL L G GGM+S+AC +A +L + +G R++IAAVNG S+VV++ Sbjct 663 SLRDAVRVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGSRVSIAAVNGRSAVVVS 722 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 G+ A+ EL+ C +R RRIDVDYASHS +V+AIR++L AL GIEPR+S +AFFST Sbjct 723 GDVAALDELVGFCADLELRTRRIDVDYASHSVEVEAIRDDLAQALSGIEPRSSRIAFFST 782 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLV- 846 VTG +DTAG++A+YWYR+IRQ VQF++AVR+A + GYR F+ESSPHP L+AGIE+T Sbjct 783 VTGNRLDTAGLDADYWYRNIRQTVQFDQAVRSASEHGYRTFIESSPHPALVAGIEDTANH 842 Query 847 DCDRGA-TGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTY 905 R A E VIPTLGRDDGG+ RF S A VAGV V WR G VELPTY Sbjct 843 HAGRDAEASEAKVIPTLGRDDGGLDRFLTSVATAFVAGVSVGWRGVLD--GAGFVELPTY 900 Query 906 AFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLAD 965 AF R+RFWL G GA D G+GL +EH LL+AVV+ P SGGVVLTGR+S WL D Sbjct 901 AFDRRRFWLSGEGA-AADATGLGLGASEHPLLSAVVELPSSGGVVLTGRLSPSLQGWLTD 959 Query 966 HAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-----VRVQVVVGGV 1020 HAV V+FPG GFVELA+RAGDEVGCS + ELTLQAPL+LPA G V VQVVVG Sbjct 960 HAVSGAVVFPGAGFVELAIRAGDEVGCSTVDELTLQAPLMLPAKGSGAGSVAVQVVVGPA 1019 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++G R V ++S + D+ GW HA+G L GSV+P A+LS WPP GA A+D ADGY+ Sbjct 1020 TETGQRVVSIFS---RPDTGSGWVCHAEGTLSTGSVEPGADLSAWPPAGAVAVDPADGYE 1076 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGV-PIRGFGIHPAVLDAALHAWGIVE 1139 LAARGYGYGPAF+GL A W RG E+FA+V LP+ + GFG+HPA+LDAA+HA +V Sbjct 1077 QLAARGYGYGPAFQGLTAAWVRGDEIFAEVRLPDAAGSVNGFGVHPALLDAAMHA--LVI 1134 Query 1140 GEQ------QTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G Q + +LPF WQGV LHA+GA+ VR R+AP G AVS+ELAD GLPVLSVR + Sbjct 1135 GHQMADHTDEVVLPFFWQGVSLHAAGASAVRARIAPAGASAVSIELADGLGLPVLSVRAM 1194 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQ---AGGD 1248 + R VS L + S +G L E+ W+P G E PPH + A D Sbjct 1195 VARSVSERQLRAAVSASGPDRLFEVEWSPATAGAG---------ETPPHEVFESLAAEED 1245 Query 1249 VLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQA 1308 + YR HE L ++SWL+ +GL VV TRGA+G +DV DLAGAAVWGLVRSAQ Sbjct 1246 PITGSYRRTHEALAAVRSWLSERDSGLLVVATRGAMGLAGEDVPDLAGAAVWGLVRSAQT 1305 Query 1309 EHPGRVVLVDTDGSVAVED-AVGFGARSGEPQLVVRRGRVYAARL--APVAAGLTLPSAS 1365 EHPGR+VLVD+D VA++D A+ GEPQ+++R G+ + AR+ + G+ P S Sbjct 1306 EHPGRIVLVDSD--VALDDSAIATALAVGEPQVLLRDGKAHTARVRGSRAVGGIMTPPES 1363 Query 1366 AGGWRLVAGGGGTLADVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGE 1423 G WRL GT ++ + PV A L GQVRVA+ A+ NFRDV++ LGM+ Sbjct 1364 -GPWRLGISSAGTFENLQLEPVPNADAPLEPGQVRVALRAIATNFRDVMITLGMFTHEAL 1422 Query 1424 LGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAV 1481 LG +GAGVVVEVGPGVT VGD V G GS +V D RL+ PA WS EAA + Sbjct 1423 LGGEGAGVVVEVGPGVTEFEVGDSVYGFFP-DGSGTLVPGDVRLLQRKPADWSYAEAAGI 1481 Query 1482 PVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLR 1541 F TA+ LAEV GQ+VLVHA GGVGMAAV LAR+ G EVF TASR KWDTLR Sbjct 1482 SAVFTTAYMAFIHLAEVQPGQRVLVHAAAGGVGMAAVQLARHLGLEVFATASRGKWDTLR 1541 Query 1542 AMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGK 1601 AMGFDD HISDSRSLEFE+ F T G+G+DVVL+SLAGEF DASLRL+ GG F+E+GK Sbjct 1542 AMGFDDDHISDSRSLEFEDKFRSVTGGAGMDVVLDSLAGEFVDASLRLVAPGGMFLEMGK 1601 Query 1602 TDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCA 1661 TDIRD VA+ + VRYRAFDL E G R+ + E+ GL AGVL LPV TFD R Sbjct 1602 TDIRDPGAVAQEYPDVRYRAFDLFEPGRPRMHQWMIELAGLFDAGVLEPLPVTTFDVRRG 1661 Query 1662 PAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVAN 1721 AA R++SQARHIGKVV+T+P GPG +GLA GTV++TGGTGMAGS +A HLV HGV + Sbjct 1662 RAALRYLSQARHIGKVVMTVPTGPG--AGLASGTVLITGGTGMAGSTLARHLVAHHGVED 1719 Query 1722 LVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHA 1781 L L+SR G A AAE+ A L GA+ V++CD ADR ALAA++ L PL GV HA Sbjct 1720 LALLSRRGPDAPGAAELIAELEAAGARARVIACDAADRTALAAVITELSATRPLSGVIHA 1779 Query 1782 AGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGN 1841 AGVLDDA++T LTP+R+D VLR+K+D AWNLHELT D++LSAFV+FSSMAG+VG+ QGN Sbjct 1780 AGVLDDAMLTSLTPERIDAVLRSKIDAAWNLHELTRDLNLSAFVMFSSMAGLVGSSGQGN 1839 Query 1842 YAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQ 1901 Y AAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D AR+ + G+ L++++ Sbjct 1840 YGAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGRDGILALSSDE 1899 Query 1902 ALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMS 1960 A+ DTAL D + AR+D AL A+P +F+ L PTRRR+ D+ A S S Sbjct 1900 AMELFDTALIVDEPFLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDSLAAAKSKS 1959 Query 1961 GLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNR 2020 L RL L+ + L DLV S+ A VLG +S+ I+ KAFQ+LGFDSLTAVE+RNR Sbjct 1960 ALAHRLDGLSEAEQHAVLLDLVRSHIATVLGNTSAEAIDPDKAFQELGFDSLTAVEMRNR 2019 Query 2021 LKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTA 2054 LKTATGL LSPTLIFDYPTP LA ++ + L A Sbjct 2020 LKTATGLALSPTLIFDYPTPNGLAGYIRTELAGA 2053 Score = 1941 bits (5029), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1149/2073 (56%), Positives = 1386/2073 (67%), Gaps = 80/2073 (3%) Query 30 LARTTE--PVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPD 87 +AR TE P+ +VGM CRYPGGV+SPE LW+++ RD +S+FP DRGWD+AG+++PDPD Sbjct 2062 VARATEDDPIVIVGMACRYPGGVNSPEDLWQMLTERRDVLSDFPTDRGWDLAGVYNPDPD 2121 Query 88 AVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDPITLR 147 G YTR GGF+ VA FD FFGIAPSEALAMDPQQR+ LE+SWEALERAGI+P LR Sbjct 2122 VPGTCYTRTGGFVDGVADFDPAFFGIAPSEALAMDPQQRMFLELSWEALERAGIEPGALR 2181 Query 148 GSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACS 207 GS TG+FAGV+ YG E + L G + SVASGRV+YVLGL+GPAVSVDTACS Sbjct 2182 GSATGMFAGVYTQGYGIDAAPTA--EGFRLTGQSSSVASGRVSYVLGLEGPAVSVDTACS 2239 Query 208 SSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGT 267 SSLVALH+AVQSLR GECDLAL GGVTV ATP +F+EFSR R LS DGRCKAYAGAADGT Sbjct 2240 SSLVALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRCKAYAGAADGT 2299 Query 268 AFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALAS 327 F+EG G+LV+ RL+DA+RLGHPVLA+VRGSAVNQDGASNGL PNGP+QQRV+ AALA+ Sbjct 2300 GFSEGGGMLVVERLSDAQRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALAN 2359 Query 328 ARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQ-RPADRPLWLGSIKSNIGHTSAAAG 386 A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ R + PLWLGSIKSN+GHT AAAG Sbjct 2360 AGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGSGGPLWLGSIKSNMGHTQAAAG 2419 Query 387 VAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVPGRPRRAGVSSFG 446 VAGVIKMVQAMRH LP TLHVD P+PHVDWSAGAVSLLTE R W RPRRAGVSSFG Sbjct 2420 VAGVIKMVQAMRHETLPATLHVDEPSPHVDWSAGAVSLLTEARAWSAE-RPRRAGVSSFG 2478 Query 447 ISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTNQARRLLAWVGADENVR 506 ISGTNAHVI+E APA E V + +PWV+SA+S AL +QA RL + A ++ Sbjct 2479 ISGTNAHVIIEAAPA-ETVQVTERPEVPVLPWVVSAKSPSALRSQAARLATHLRAHPDLD 2537 Query 507 PLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVGKTAFVF 566 +DVGW+L RS F+ RAV+V DR +L+ GL LAA ++ G A GKT FVF Sbjct 2538 AVDVGWTLAG-RSTFEQRAVIVADDRDRLLAGLDELAADELAQSIIRGTAAPGGKTVFVF 2596 Query 567 PGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQ 626 PGQG+Q LGMG L P+FAE L +H+ L DV+ G+ + L+ + Q Sbjct 2597 PGQGSQLLGMGRGLHDAYPMFAEAFDAVLAELDQHLLRPLRDVIWGSDESL-LNTTEFAQ 2655 Query 627 PALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRL 686 PAL+AV V+L L S G+ PD V+GHS GE++AA+ AG LSL++AA +VA R R + L Sbjct 2656 PALFAVEVALFRLLESWGIHPDFVMGHSIGELSAAHAAGVLSLKNAAVLVAARGRFMQAL 2715 Query 687 GGAGGMVSLACGQPQAEK-LASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGI 745 G MV++ + + L D + IAAVNG +SVV++G AVT + + AEG Sbjct 2716 PAGGAMVAVQATEDEVRPLLVPSEQDSVGIAAVNGPASVVISGTQGAVTAIADQLRAEGR 2775 Query 746 RARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYR 805 R ++ V +A HS +DA+ +E G+ T+ S VTG L A YW R Sbjct 2776 RVHQLAVSHAFHSPLMDAMIDEFGTVAAGLTIGKPTIPIVSNVTGGLATDDFGTAAYWKR 2835 Query 806 SIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRD 865 +R+ V+F +VR G F+E P L A IEETL D P+ + R Sbjct 2836 HVREAVRFADSVRFVHAAGGNRFLEVGPSSGLTASIEETLAD-------NPVTTMSALRK 2888 Query 866 DGGVGRFWLSA-GQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGAVGGDL 924 D ++A VAG+ VDWR A VELPTYAF R+RFWL A D Sbjct 2889 DRPEPTALVNAVAHGFVAGMAVDWRGAIGT--ANLVELPTYAFDRRRFWLSRDDAP-ADA 2945 Query 925 GGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFVELAL 984 G+GL EH LL AVV+ P SGGVVLTGR+S WLADHAVG VVLFPG GFVELA+ Sbjct 2946 AGLGLAPGEHALLGAVVELPASGGVVLTGRLSSGTQGWLADHAVGGVVLFPGAGFVELAI 3005 Query 985 RAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGW 1043 RAGDEVGC +L EL L APLVLPA G V VQVVVGG + SG R V V+S +A++ GW Sbjct 3006 RAGDEVGCGILDELNLAAPLVLPAGGSVAVQVVVGGPDDSGARAVSVFS---RAEAGSGW 3062 Query 1044 TLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRG 1103 +LHA+GVL GSV+P A+LS WPP GA ++V DGY+ LA RGYGYGPAFRGL ++WRRG Sbjct 3063 SLHAEGVLRAGSVEPGADLSAWPPAGAVPVEVGDGYEQLAERGYGYGPAFRGLTSMWRRG 3122 Query 1104 AEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEGEQ------QTMLPFSWQGVCL 1155 E+FA+VTLP GV + GFG+HP +LDAALHA I+ E ++PFSWQ V L Sbjct 3123 DEIFAEVTLPSDAGVSVSGFGVHPVLLDAALHAV-ILSSESDELAPGSILVPFSWQQVSL 3181 Query 1156 HASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAAL--SRSTAGDRGL 1213 HA+GAA VR R+ PVG AVS+ELAD GLPVLSV ++ RPV+ L + S +G L Sbjct 3182 HAAGAAAVRARIMPVGASAVSIELADGLGLPVLSVASMVARPVTDQQLLAAVSNSGPDRL 3241 Query 1214 LEMIWTPVP-------------------LEGGDIGDDAVVWELPPHAGAQAGGDVLAAVY 1254 E+IW+ P + G+ G V++E P GDV+ VY Sbjct 3242 FELIWSAQPTSTVQPVSVSAWGAPESAEYDNGEAGLSVVLFESEP-----VSGDVITEVY 3296 Query 1255 RGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRV 1314 VL VLQSWL+ D TG VV TRGA+ +DVTDLAGAAVWGLVRSAQ EHPGR+ Sbjct 3297 AATRAVLPVLQSWLSRDVTGTLVVATRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHPGRI 3356 Query 1315 VLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAAR-LAPVAAGLTLPSASAGGWRLVA 1373 VLVDTD + DA+ GEPQ + R G VY AR L A G L G WRL Sbjct 3357 VLVDTDAPLD-PDAIAAVLAVGEPQALRRNGMVYTARVLGSRAVGGLLTPPEQGPWRLGM 3415 Query 1374 GGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPG-GGELGVDGAG 1430 GT+ ++ + P A L GQVRVA+ A+ NFRDV++ALG+YP +G++ AG Sbjct 3416 SSYGTIENLRIERIPDADAPLGPGQVRVALSAIAANFRDVMIALGLYPDPDAIMGIEAAG 3475 Query 1431 VVVEVGPGVTGLAVGDRVMGLL-GLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAF 1489 V+ E VGDRVMGL G+ A D RL+ VPAGWS AA V F TA Sbjct 3476 VITETASQDGRFEVGDRVMGLFPDGTGTIAKTDERLLVKVPAGWSHTAAATASVVFATAR 3535 Query 1490 YGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIH 1549 Y L LA GQ+VLVHA GGVGMAAV LAR G EVF TASR KWDTLRAMGFDD H Sbjct 3536 YALVDLAAAKPGQRVLVHAAAGGVGMAAVQLARQIGLEVFATASRGKWDTLRAMGFDDDH 3595 Query 1550 ISDSRSLEFEEAFLRATEG----SGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIR 1605 I DSRSLEFE+ F RA G +G+D+VL+SL+GEF DASLRL+ GG F+E+GKTDIR Sbjct 3596 IGDSRSLEFEDKF-RAVTGRTGTAGMDIVLDSLSGEFVDASLRLVAPGGVFLEMGKTDIR 3654 Query 1606 DGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAY 1665 D + VA H GVRYRAFDL EAGPDRIA ML E+ + A VL LPV FD R APAA Sbjct 3655 DPEVVARDHSGVRYRAFDLFEAGPDRIAQMLDELAAMFAEDVLRPLPVTRFDVRRAPAAL 3714 Query 1666 RFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLV 1725 R++SQARH+GKVV+T+PD GTV++TG TGMAGSAVA H+V RHG N+VLV Sbjct 3715 RYLSQARHVGKVVMTMPD------AWTAGTVLITGATGMAGSAVARHVVTRHGARNVVLV 3768 Query 1726 SRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVL 1785 SR G A AAE+ A LR GA V+CD ADR+ALA ++A + + PL GV HAAGVL Sbjct 3769 SRRGLDAPGAAELVAELRAAGAHAEAVACDAADREALAKVIADIPMQRPLTGVIHAAGVL 3828 Query 1786 DDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAA 1845 DDAV+T L P+R+ VLR+KVD AWNLHELT D+D+SAFV+FSS+AG+ G Q NYAA Sbjct 3829 DDAVVTSLNPERMAAVLRSKVDAAWNLHELTRDLDVSAFVMFSSIAGLAGASGQANYAAG 3888 Query 1846 NAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGF 1905 N+FLDGL A+RR+ GL +S+ WGLW+QASAMT LG D AR + G+ +++EQAL Sbjct 3889 NSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARFGRDGIVAMSSEQALEL 3948 Query 1906 LDTALQADRAVVVAARLDRAAL--AGAGAALPALFSQLAAGPTRRRIDAADTAV-SMSGL 1962 +DTAL D ++ A +D AAL LP +F L PTRR++D + TA S S L Sbjct 3949 MDTALIVDEPFMLPAHIDLAALRVKFDSGTLPPMFVDLINAPTRRQVDDSLTAAKSKSAL 4008 Query 1963 VSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLK 2022 + RL L + +Q L DLV S+ A VLG SS I+ +AFQ+LGFDSLTAVE+RNRLK Sbjct 4009 LQRLEGLPEDEQQAILLDLVRSHIATVLGSSSPEAIHPDRAFQELGFDSLTAVEMRNRLK 4068 Query 2023 TATGLTLSPTLIFDYPTPATLAEHLDSRLVTAS 2055 ATGL LSPTLIFDYP A LA ++ LV AS Sbjct 4069 AATGLALSPTLIFDYPNSAALAGYMHRELVGAS 4101 >gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] gi|148506014|gb|ABQ73823.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] Length=4151 Score = 2190 bits (5674), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1254/2056 (61%), Positives = 1484/2056 (73%), Gaps = 41/2056 (1%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA RD +SE Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSE 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPD KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK YAG ADG ++EG G+LVL RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR++ FFST Sbjct 724 GEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LSA A VAGV V+WR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHA 967 ++RFWL G+ G D+ G+GL +EH LL AVV P SGGVVLTGR+S PWLADHA Sbjct 901 DKRRFWLSAEGS-GADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHA 959 Query 968 VGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSGTR 1026 V VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S +R Sbjct 960 VSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSR 1019 Query 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 V ++S +AD+ GW LHA+G+L GSV+P A+LSVW P GA +DVADGY+ LA RG Sbjct 1020 GVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWAPAGAVTVDVADGYERLATRG 1076 Query 1087 YGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQQTM 1145 Y YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I + Sbjct 1077 YRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPDELA 1136 Query 1146 LPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAALSR 1205 LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ L Sbjct 1137 LPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQLLA 1196 Query 1206 STAG---DRGLLEMIWTPVPLEGGDIGDDAV-VWELPPHAGAQAGGDVLAAVYRGVHEVL 1261 + +G DR L E+IW+P A ++E A D +A Y H+ L Sbjct 1197 AVSGSGPDR-LFEVIWSPASAATSPGPTPAYQIFE-----SVAADQDPVAGSYVRSHQAL 1250 Query 1262 EVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDG 1321 +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+D Sbjct 1251 AAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDA 1310 Query 1322 SVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGTLA 1380 + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1311 ATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1381 DVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1439 VTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLA 1496 VT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y LA Sbjct 1430 VTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLA 1488 Query 1497 EVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSL 1556 +V GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSRSL Sbjct 1489 DVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL 1548 Query 1557 EFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERHRG 1616 EFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ G Sbjct 1549 EFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPG 1608 Query 1617 VRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGK 1676 VRYRAFDL E G R+ + E+ L GVL LPV TFD R APAA R++SQARH GK Sbjct 1609 VRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGK 1668 Query 1677 VVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAA 1736 VV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A AA Sbjct 1669 VVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAA 1722 Query 1737 EVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPD 1796 E+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+ LTPD Sbjct 1723 ELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVMSLTPD 1782 Query 1797 RVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYR 1856 RVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A+R Sbjct 1783 RVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHR 1842 Query 1857 RSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAV 1916 R+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1843 RAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDEPF 1902 Query 1917 VVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPERRQ 1975 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L + Sbjct 1903 LAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQH 1962 Query 1976 RELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF 2035 L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTLIF Sbjct 1963 AVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIF 2022 Query 2036 DYPTPATLAEHLDSRL 2051 DYPTP LA ++ + L Sbjct 2023 DYPTPNRLASYIRTEL 2038 Score = 1999 bits (5179), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1164/2091 (56%), Positives = 1412/2091 (68%), Gaps = 65/2091 (3%) Query 4 TPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHG 63 TP L +R L + + + + +P+A+VGM CRYPGGV+SP+ +W+++ G Sbjct 2026 TPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG 2085 Query 64 RDAVSEFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDP 123 RD +SEFPADRGWD+AGL++PDPDA G YTR GGF+ V FD FFG+ PSEALAMDP Sbjct 2086 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDP 2145 Query 124 QQRLLLEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLS 183 Q R+LLE+SWEALERAGIDP LRGS TGVFAGV YG P +E + L G S Sbjct 2146 QHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEP--VEGFRLTGQLSS 2203 Query 184 VASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFI 243 VASGRVAYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+ Sbjct 2204 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV 2263 Query 244 EFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQD 303 EFSR R LS DGRCKA+A AADGT F+EG G+LVL RL+DARRLGHPVLA+V GSAVNQD Sbjct 2264 EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 2323 Query 304 GASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQR 363 GASNGL PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ Sbjct 2324 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 2383 Query 364 PAD--RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGA 421 + PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGA Sbjct 2384 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 2443 Query 422 VSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLS 481 V LLT PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+S Sbjct 2444 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVS 2501 Query 482 ARSAQALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTG 541 A+S AL QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL Sbjct 2502 AKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDE 2560 Query 542 LAAGVPGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREH 601 LA G VV G A GKT FVFPGQG+QWLGMG L A PVFAE + L H Sbjct 2561 LAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRH 2620 Query 602 VEWSLLDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAA 661 + L +V+ G L+ + QPAL+AV V+L L S GV PD V+GHS GE++AA Sbjct 2621 LLRPLREVMWGH-DENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAA 2679 Query 662 YVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGV 721 +VAG LSL +AA +VA R RL+ L G MV++ + + L S ++IAAVNG Sbjct 2680 HVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSA---EVDIAAVNGP 2736 Query 722 SSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTST 781 +S+V++G +AV + + A+G R ++ V +A HS +D + +E A GI T Sbjct 2737 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPT 2796 Query 782 VAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGI 841 + S VTG+L +A YW R IRQ V+F +VR A G F+E P L+A I Sbjct 2797 IGVISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASI 2856 Query 842 EETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVE 901 EE+L D + L +D + Q V G+ +DWRA + + VE Sbjct 2857 EESLPDV------AVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE--AQFVE 2908 Query 902 LPTYAFARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAP 961 LPTYAF R+RFWL G G V D G+GL +EH LL AV+ P SGGVVLTGR+S Sbjct 2909 LPTYAFQRRRFWLSGDG-VAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQG 2967 Query 962 WLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGV 1020 WLADH+V V +FPG GFVELA+RAGDEVGC V+ ELTL APLVLPA G V VQVVV G Sbjct 2968 WLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP 3027 Query 1021 EQSGTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQ 1080 ++SG R V VYS + D GW LHA+G L GS +P A+L++WPP GA ++VADGYQ Sbjct 3028 DESGVRGVSVYS---RGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQ 3084 Query 1081 VLAARGYGYGPAFRGLQALWRRGAEVFADVTLP--EGVPIRGFGIHPAVLDAALHAWGIV 1138 LA RGYGYGPAFRGL A+WRRG EVFA+V LP GV + GFG+HP +LDAALHA + Sbjct 3085 QLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLS 3144 Query 1139 -----EGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQL 1193 G+ ++PFSWQGV LHA+GA+ VR R+APVG AVS+ELAD GLPVLSV + Sbjct 3145 AESAERGQGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASM 3204 Query 1194 MVRPVSAAAL--SRSTAGDRGLLEMIWTPVPLEG---------GDIGDD-AVVWELPPHA 1241 + RPV+ L + S++G L E+ W+P P G D AVV+E P A Sbjct 3205 LARPVTDQQLRAAVSSSGPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLA 3264 Query 1242 GAQAGGDVLAAVYRGVHEVLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWG 1301 GDV+A VY VL+VLQSWL D G+ VV+TRGAV +DVTDLAGAAVWG Sbjct 3265 -----GDVVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWG 3319 Query 1302 LVRSAQAEHPGRVVLVDTDGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL--APVAAGL 1359 LVRSAQ EHPGR+VLVD+D + + A+ +GEPQ++ RRG VY AR+ + GL Sbjct 3320 LVRSAQTEHPGRIVLVDSDAPLD-DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGL 3378 Query 1360 TLPSASAGGWRLVAGGGGTLADVVVA--PVAPVELATGQVRVAVGAVGVNFRDVLVALGM 1417 +P S WRL GT ++ + P A L GQVRVAV A+ NFRDV++ALG+ Sbjct 3379 LVPP-SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 1418 YPG-GGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGL-VGSEAVVDARLVTMVPAGWSL 1475 YP +GV+ GVV+E AVGDRVMGL G+ A D RL+ VPAGWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1476 VEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRA 1535 AA V F TA Y L LA +GQ+VL+HAGTGGVGMAAV LAR+ G EVF TAS+ Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1536 KWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGR 1595 KWDTLRAMGFDD HISDSRSLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1596 FIELGKTDIRDGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKT 1655 F+E+GKTDIRD +A+++ GVRYRAFDL E GPDRIA +L+E+ L GVL LPV T Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1656 FDARCAPAAYRFVSQARHIGKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVR 1715 FD RCAPAA R++SQARH GKVV+ +P A GTV++TGGTGMAGSAVA H+V Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVA 3731 Query 1716 RHGVANLVLVSRSGEQADRAAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPL 1775 RHGV NLVLVSR G A AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL Sbjct 3732 RHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPL 3791 Query 1776 KGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVG 1835 GV H AG LDDAV+ LTPDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG Sbjct 3792 SGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG 3851 Query 1836 TPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLA 1895 + Q NYAAAN+FLD L A+RR+ GL +S+ WGLW+QASAMT L D R + G+ Sbjct 3852 SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIV 3911 Query 1896 PLTTEQALGFLDTALQADRAVVVAARLDRAALAGA--GAALPALFSQLAAGPTRRRI-DA 1952 +++ AL DTA+ D ++ A +D AAL G LP +F L PTRR++ D+ Sbjct 3912 AMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDS 3971 Query 1953 ADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSL 2012 A S S L+ RL L + + L DLV S+ A VLG +S I+ +AFQ+LGFDSL Sbjct 3972 LAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSL 4031 Query 2013 TAVELRNRLKTATGLTLSPTLIFDYPTPATLAEHLDSRLVTASGSDQQSLS 2063 TAVE+RNRLK+ATGL LSPTLIFDYP A LA ++ L+ +S D +++ Sbjct 4032 TAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDTSAVA 4082 >gi|340627059|ref|YP_004745511.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] gi|340005249|emb|CCC44403.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] Length=4154 Score = 2181 bits (5651), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1252/2058 (61%), Positives = 1481/2058 (72%), Gaps = 42/2058 (2%) Query 10 KALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSE 69 +ALR++L Q ERLKR NR LL R++EP+A+VGM CR+PGGVDSPE LW++VA GRD +S Sbjct 10 EALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVAEGRDVISG 69 Query 70 FPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLL 129 FP DRGWD+AGLFDPDPDA KSY R GGF+ VA FD FFGI+PSEALAMDPQ R+LL Sbjct 70 FPTDRGWDLAGLFDPDPDARHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLL 129 Query 130 EVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRV 189 E+SWEALERAGIDP LRGS TGVFAG+ G YG + ++E Y L G T SVASGRV Sbjct 130 ELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG---MLAEEIEGYRLTGMTSSVASGRV 186 Query 190 AYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQR 249 AYVLGL+GPAVSVDTACSSSLVALH+AV SLR GECDLAL GGVTV ATP +F+EFSR R Sbjct 187 AYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHR 246 Query 250 ALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNGL 309 L+ DGRCK Y GAADG ++EG G+L L RL+DARRLGHPVLA+V GSAVNQDGASNGL Sbjct 247 GLAPDGRCKPYGGAADGVGWSEGGGMLALERLSDARRLGHPVLAVVVGSAVNQDGASNGL 306 Query 310 ATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPAD--R 367 PNGP+QQRV+ AALA+A L A+VDVVEGHGTGTTLGDPIEAQA+LATYGQ + Sbjct 307 TAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGE 366 Query 368 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTE 427 PLWLGS+KSN+GHT AAAGVAGVIKMV AMRH +LP TLHVDVP+PHVDWSAGAV LLT Sbjct 367 PLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTA 426 Query 428 PRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQA 487 PR W R RRAGVSSFGISGTNAHVI+E P V P A PV VPWV+SA+S A Sbjct 427 PRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVV-PRREAGWAGPV-VPWVVSAKSESA 484 Query 488 LTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVP 547 L QA RL A+V D+ + DVGWSL RS+F+HRAVVVG DR +L+ GL LA Sbjct 485 LRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQL 543 Query 548 GADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLL 607 G VV G A GKT FVFPGQG+QWLGMG +L TAP FA+ I C A E V+WSL+ Sbjct 544 GGSVVRGTATPAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLV 603 Query 608 DVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGAL 667 DVLRGAPGAPGLDRVDVVQP L+AVMVSLAELW+SV V PDAVIGHSQGEIAAAYVAGAL Sbjct 604 DVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVRPDAVIGHSQGEIAAAYVAGAL 663 Query 668 SLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVLA 727 SLRDAA VV LRS+LL L G GGMVS+ACG QA L + +GDR++IA VNG S+VV++ Sbjct 664 SLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVS 723 Query 728 GETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFST 787 GE A+ EL+ C + +R RRI+VDYASHS +V+AIR L AL GIEPR + FFST Sbjct 724 GEVGALEELIALCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRPTRTVFFST 783 Query 788 VTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVD 847 VTG +DTAG++A+YWYR++RQ V F++AVRNA + GYR F+ESSPHP LI G+EET Sbjct 784 VTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETFAA 843 Query 848 CDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAF 907 C G + E IV+PTLGR DGG+ RF LS A VAGV VDWR G VELPTYAF Sbjct 844 CTDGDS-EAIVVPTLGRGDGGLHRFLLSTASAFVAGVAVDWRGTLD--GAGYVELPTYAF 900 Query 908 ARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGG---VVLTGRISVVAAPWLA 964 ++RFWL G+ G D G+GL +EH LL AVV P SGG +VLTGR+S PWLA Sbjct 901 DKRRFWLSAEGS-GADAFGLGLGASEHPLLGAVVDLPASGGMVLMVLTGRLSPNVQPWLA 959 Query 965 DHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQS 1023 DHAV VVLFPGTGFVELA+RAGDEVGCSVL ELTL APL+LPA G V VQVVV S Sbjct 960 DHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDS 1019 Query 1024 GTRNVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLA 1083 +R V ++S +AD+ GW LHA+G+L GSV+P A+LSVWPP GA A+DVADGY+ LA Sbjct 1020 NSRGVSIFS---RADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVAVDVADGYERLA 1076 Query 1084 ARGYGYGPAFRGLQALWRRGAEVFADVTLPE-GVPIRGFGIHPAVLDAALHAWGIVEGEQ 1142 GY YGPAFRGL A+W RG E+FA+V LPE + GFG+HPA+LDA LHA I Sbjct 1077 TCGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVIAGDPD 1136 Query 1143 QTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSAAA 1202 + LPF+WQGV LHA+GA+ VR R+AP G AVSVELAD GLPVLSV ++ RPV+ Sbjct 1137 ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTERQ 1196 Query 1203 LSRSTAG---DRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHE 1259 L + +G DR L E+IW+ G +++ A D +A Y H+ Sbjct 1197 LLAAVSGSGPDR-LFEVIWSRA--SGVTALGSTPAYQI--FESVAADQDPVAGSYVRSHQ 1251 Query 1260 VLEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDT 1319 L +QSWL +G+ VV TRGA+ +DV DLAGAAVWGLVRSAQ EHPGR+VLVD+ Sbjct 1252 ALAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDS 1311 Query 1320 DGSVAVEDAVGFGARSGEPQLVVRRGRVYAARL-APVAAGLTLPSASAGGWRLVAGGGGT 1378 D + A +GEPQ+V+R G+VY AR+ AA L G WRL G GT Sbjct 1312 DAATDDAAIAMALA-TGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGT 1370 Query 1379 LADVVVAPV--APVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVG 1436 ++ + PV A L GQVRVA+ A+ NFRD+++ LGM+ LG +GAGVVVEVG Sbjct 1371 FENLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVG 1430 Query 1437 PGVTGLAVGDRVMGLLGLVGSEAVV--DARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSV 1494 PGVT +VGD V G GS +V D RL+ +PA WS EAAA+ F TA+Y Sbjct 1431 PGVTEFSVGDSVFGFFP-DGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIH 1489 Query 1495 LAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSR 1554 LA+V GQ+VL+HA TGGVGMAAV LAR+ G EVF TAS+ KWDTLRAMGFDD HISDSR Sbjct 1490 LADVQPGQRVLIHAATGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSR 1549 Query 1555 SLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTVAERH 1614 SLEFE+ F AT G G DVVL+SLAGEF DASLRL+ GG F+E+GKTDIRD +A+++ Sbjct 1550 SLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQY 1609 Query 1615 RGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHI 1674 GVRYRAFDL E G R+ + E+ L GVL LPV TFD R APAA R++SQARH Sbjct 1610 PGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHT 1669 Query 1675 GKVVLTIPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADR 1734 GKVV+ +P A GTV++TGGTGMAGSAVA H+V RHGV NLVLVSR G A Sbjct 1670 GKVVMLMP------GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPG 1723 Query 1735 AAEVAALLREGGAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLT 1794 AAE+ A L GAQV VV+CD ADR ALA ++A + ++PL GV H AG LDDAV+T LT Sbjct 1724 AAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHPLSGVIHTAGALDDAVVTSLT 1783 Query 1795 PDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVA 1854 PDRVD VLR+KVD AW+LHELT D+D+SAFV+FSSMAG+VG+ Q NYAAAN+FLD L A Sbjct 1784 PDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAA 1843 Query 1855 YRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADR 1914 +RR+ GL +S+ WGLW+QASAMT L D AR+ + G+ L+T +AL DTA+ D Sbjct 1844 HRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAMIVDE 1903 Query 1915 AVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRI-DAADTAVSMSGLVSRLHALTPER 1973 + AR+D AL A+P +FS LA+ PTRR++ D+ A S S L RLH L Sbjct 1904 PFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAE 1963 Query 1974 RQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTL 2033 + L LV + A VLG + I+ KAFQDLGFDSLTAVE+RNRLK+ATGL+LSPTL Sbjct 1964 QHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTL 2023 Query 2034 IFDYPTPATLAEHLDSRL 2051 IFDYPTP LA ++ + L Sbjct 2024 IFDYPTPNRLASYIRTEL 2041 Lambda K H 0.319 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 5602789886600 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40