BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1662 Length=1602 Score E Sequences producing significant alignments: (Bits) Value gi|15608800|ref|NP_216178.1| polyketide synthase pks8 [Mycobacte... 3148 0.0 gi|15841118|ref|NP_336155.1| polyketide synthase [Mycobacterium ... 3146 0.0 gi|306788763|ref|ZP_07427085.1| polyketide synthase [Mycobacteri... 3145 0.0 gi|289745900|ref|ZP_06505278.1| polyketide synthase [Mycobacteri... 3145 0.0 gi|148822871|ref|YP_001287625.1| polyketide synthase pks8 [Mycob... 3144 0.0 gi|289574331|ref|ZP_06454558.1| polyketide synthase pks8 [Mycoba... 3141 0.0 gi|31792849|ref|NP_855342.1| polyketide synthase pks8 [Mycobacte... 3135 0.0 gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 [Mycob... 3107 0.0 gi|298525161|ref|ZP_07012570.1| polyketide synthase [Mycobacteri... 2998 0.0 gi|121637570|ref|YP_977793.1| putative polyketide synthase pks8 ... 2969 0.0 gi|289753752|ref|ZP_06513130.1| polyketide synthase pks8 [Mycoba... 2659 0.0 gi|289569709|ref|ZP_06449936.1| polyketide synthase pks8 [Mycoba... 2129 0.0 gi|289443120|ref|ZP_06432864.1| polyketide synthase pks8 [Mycoba... 2034 0.0 gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules ... 2030 0.0 gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 ... 2029 0.0 gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules ... 1997 0.0 gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Myco... 1962 0.0 gi|296164561|ref|ZP_06847131.1| erythronolide synthase, modules ... 1943 0.0 gi|240171787|ref|ZP_04750446.1| putative polyketide synthase [My... 1857 0.0 gi|15826966|ref|NP_301229.1| polyketide synthase [Mycobacterium ... 1855 0.0 gi|289575652|ref|ZP_06455879.1| polyketide synthase pks1 [Mycoba... 1845 0.0 gi|31794123|ref|NP_856616.1| polyketide synthase PKS1 [Mycobacte... 1843 0.0 gi|294993968|ref|ZP_06799659.1| putative polyketide synthase [My... 1841 0.0 gi|289746746|ref|ZP_06506124.1| polyketide synthase PKS1 [Mycoba... 1840 0.0 gi|183981775|ref|YP_001850066.1| polyketide synthase Pks15/1 [My... 1819 0.0 gi|118617583|ref|YP_905915.1| polyketide synthase Pks15/1 [Mycob... 1817 0.0 gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobact... 1748 0.0 gi|118463404|ref|YP_882293.1| RifB protein [Mycobacterium avium ... 1747 0.0 gi|254775560|ref|ZP_05217076.1| RifB protein [Mycobacterium aviu... 1746 0.0 gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium ... 1735 0.0 gi|289554169|ref|ZP_06443379.1| polyketide synthase Pks12 [Mycob... 1732 0.0 gi|339298599|gb|AEJ50709.1| polyketide synthase Pks12 [Mycobacte... 1731 0.0 gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_1100... 1730 0.0 gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085... 1730 0.0 gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_1090... 1730 0.0 gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycob... 1730 0.0 gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12... 1730 0.0 gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycob... 1729 0.0 gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933... 1729 0.0 gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacteri... 1729 0.0 gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 ... 1729 0.0 gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Myco... 1728 0.0 gi|340627059|ref|YP_004745511.1| putative polyketide synthase pk... 1727 0.0 gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobact... 1725 0.0 gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycoba... 1713 0.0 gi|342860755|ref|ZP_08717405.1| RifB protein [Mycobacterium colo... 1711 0.0 gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Myc... 1709 0.0 gi|289745901|ref|ZP_06505279.1| polyketide synthase pks7 [Mycoba... 1701 0.0 gi|340626667|ref|YP_004745119.1| putative polyketide synthase PK... 1699 0.0 gi|254231859|ref|ZP_04925186.1| polyketide synthase pks7 [Mycoba... 1699 0.0 >gi|15608800|ref|NP_216178.1| polyketide synthase pks8 [Mycobacterium tuberculosis H37Rv] gi|148661458|ref|YP_001282981.1| putative polyketide synthase Pks8 [Mycobacterium tuberculosis H37Ra] gi|167969221|ref|ZP_02551498.1| putative polyketide synthase Pks8 [Mycobacterium tuberculosis H37Ra] 10 more sequence titles Length=1602 Score = 3148 bits (8161), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1602/1602 (100%), Positives = 1602/1602 (100%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|15841118|ref|NP_336155.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|253799298|ref|YP_003032299.1| polyketide synthase pks8 [Mycobacterium tuberculosis KZN 1435] gi|254364506|ref|ZP_04980552.1| polyketide synthase pks8 [Mycobacterium tuberculosis str. Haarlem] 25 more sequence titles Length=1602 Score = 3146 bits (8157), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1601/1602 (99%), Positives = 1601/1602 (99%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|306788763|ref|ZP_07427085.1| polyketide synthase [Mycobacterium tuberculosis SUMu004] gi|306793097|ref|ZP_07431399.1| polyketide synthase [Mycobacterium tuberculosis SUMu005] gi|308334682|gb|EFP23533.1| polyketide synthase [Mycobacterium tuberculosis SUMu004] gi|308338475|gb|EFP27326.1| polyketide synthase [Mycobacterium tuberculosis SUMu005] Length=1602 Score = 3145 bits (8155), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1600/1602 (99%), Positives = 1601/1602 (99%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDP+EAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPVEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|289745900|ref|ZP_06505278.1| polyketide synthase [Mycobacterium tuberculosis 02_1987] gi|294996613|ref|ZP_06802304.1| polyketide synthase pks8 [Mycobacterium tuberculosis 210] gi|289686428|gb|EFD53916.1| polyketide synthase [Mycobacterium tuberculosis 02_1987] gi|326903276|gb|EGE50209.1| polyketide synthase pks8 [Mycobacterium tuberculosis W-148] gi|339294620|gb|AEJ46731.1| polyketide synthase [Mycobacterium tuberculosis CCDC5079] gi|339298253|gb|AEJ50363.1| polyketide synthase [Mycobacterium tuberculosis CCDC5180] Length=1602 Score = 3145 bits (8154), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1600/1602 (99%), Positives = 1601/1602 (99%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWE+ESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWEVESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|148822871|ref|YP_001287625.1| polyketide synthase pks8 [Mycobacterium tuberculosis F11] gi|148721398|gb|ABR06023.1| polyketide synthase pks8 [Mycobacterium tuberculosis F11] Length=1602 Score = 3144 bits (8152), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1600/1602 (99%), Positives = 1601/1602 (99%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMG+VGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGVVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|289574331|ref|ZP_06454558.1| polyketide synthase pks8 [Mycobacterium tuberculosis K85] gi|289538762|gb|EFD43340.1| polyketide synthase pks8 [Mycobacterium tuberculosis K85] Length=1602 Score = 3141 bits (8143), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1600/1602 (99%), Positives = 1600/1602 (99%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAG Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGG 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|31792849|ref|NP_855342.1| polyketide synthase pks8 [Mycobacterium bovis AF2122/97] gi|31618439|emb|CAD96357.1| Probable polyketide synthase pks8 [Mycobacterium bovis AF2122/97] Length=1602 Score = 3135 bits (8127), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1597/1602 (99%), Positives = 1597/1602 (99%), Gaps = 0/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDV GLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVYGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRF EGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFVEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAG Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGG 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAY ALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYCALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 >gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 [Mycobacterium canettii CIPT 140010059] gi|340004858|emb|CCC44003.1| polyketide synthase PKS8 [Mycobacterium canettii CIPT 140010059] Length=2105 Score = 3107 bits (8054), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1578/1582 (99%), Positives = 1580/1582 (99%), Gaps = 0/1582 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLR VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRKVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALG+YPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGMYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 Query 1561 FTDASLRLLPRGGRFIEMGKTE 1582 FTDASLRLLPRGGRFIEMGKT+ Sbjct 1561 FTDASLRLLPRGGRFIEMGKTD 1582 >gi|298525161|ref|ZP_07012570.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|298494955|gb|EFI30249.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=1542 Score = 2998 bits (7772), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1528/1529 (99%), Positives = 1528/1529 (99%), Gaps = 0/1529 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1380 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHV 1529 RLWGLEVFATASRGKWDTLHTMGCDNTHV Sbjct 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHV 1529 >gi|121637570|ref|YP_977793.1| putative polyketide synthase pks8 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990045|ref|YP_002644732.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|121493217|emb|CAL71688.1| Probable polyketide synthase pks8 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224773158|dbj|BAH25964.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601588|emb|CCC64261.1| probable polyketide synthase pks8 [Mycobacterium bovis BCG str. Moreau RDJ] Length=1601 Score = 2969 bits (7697), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1596/1602 (99%), Positives = 1596/1602 (99%), Gaps = 1/1602 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDV GLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVYGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVV AASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVV-AASEEEVLPVLVDGANLAAVNAPHSVVV 719 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 720 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 779 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRF EGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 780 NVTGQMAGAGYGDGQYWVEHARRPVRFVEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 839 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 840 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 899 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 900 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 959 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 960 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1019 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1020 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1079 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1080 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1139 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1140 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1199 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAG Sbjct 1200 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGG 1259 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1260 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1319 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEV 1380 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEV Sbjct 1320 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEV 1379 Query 1381 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1440 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV Sbjct 1380 RALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVV 1439 Query 1441 DARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1500 DARLVVKLPNRWPLTDAAGVPVVFLTAY ALRVLAQVQPGESVLVHAAAGGVGMAAVQLA Sbjct 1440 DARLVVKLPNRWPLTDAAGVPVVFLTAYCALRVLAQVQPGESVLVHAAAGGVGMAAVQLA 1499 Query 1501 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1560 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE Sbjct 1500 RLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGE 1559 Query 1561 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1602 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST Sbjct 1560 FTDASLRLLPRGGRFIEMGKTEFGTPRSLPRTILGWPTGLST 1601 >gi|289753752|ref|ZP_06513130.1| polyketide synthase pks8 [Mycobacterium tuberculosis EAS054] gi|289694339|gb|EFD61768.1| polyketide synthase pks8 [Mycobacterium tuberculosis EAS054] Length=1358 Score = 2659 bits (6893), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1354/1356 (99%), Positives = 1354/1356 (99%), Gaps = 0/1356 (0%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA Sbjct 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM Sbjct 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS Sbjct 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD Sbjct 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNG SQQRVIRAALASARLR VEVDVVEGHGTGTMLGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGSSQQRVIRAALASARLRRVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL Sbjct 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA Sbjct 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL Sbjct 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL Sbjct 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL Sbjct 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV Sbjct 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS Sbjct 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP Sbjct 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW Sbjct 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYW 900 Query 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL Sbjct 901 LPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVL 960 Query 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR Sbjct 961 LAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG Sbjct 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV Sbjct 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGV 1140 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA Sbjct 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 Query 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR Sbjct 1201 GRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGR 1260 Query 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI Sbjct 1261 LVVLTQGSVGQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMI 1320 Query 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG 1356 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG Sbjct 1321 RNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG 1356 >gi|289569709|ref|ZP_06449936.1| polyketide synthase pks8 [Mycobacterium tuberculosis T17] gi|289543463|gb|EFD47111.1| polyketide synthase pks8 [Mycobacterium tuberculosis T17] Length=1096 Score = 2129 bits (5517), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1090/1094 (99%), Positives = 1090/1094 (99%), Gaps = 0/1094 (0%) Query 509 GWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESGAGVAVGRARSVGKTVFVFPGQG 568 GWSLVKTRAMFEHRAVVVGADRGALLAG AALAAGESGAGVAVGRARSVGKTVFVFPGQG Sbjct 3 GWSLVKTRAMFEHRAVVVGADRGALLAGWAALAAGESGAGVAVGRARSVGKTVFVFPGQG 62 Query 569 AQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQPALFA 628 AQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQPALFA Sbjct 63 AQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQPALFA 122 Query 629 IEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGV 688 IEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGV Sbjct 123 IEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGV 182 Query 689 MVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSH 748 MVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSH Sbjct 183 MVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSH 242 Query 749 AFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFA 808 AFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFA Sbjct 243 AFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFA 302 Query 809 EGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSVLGAVATLF 868 EGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSVLGAVATLF Sbjct 303 EGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSVLGAVATLF 362 Query 869 TAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVV 928 TAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVV Sbjct 363 TAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVV 422 Query 929 EQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVV 988 EQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVV Sbjct 423 EQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVV 482 Query 989 TPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLS 1048 TPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLS Sbjct 483 TPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLS 542 Query 1049 VWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGF 1108 VWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGF Sbjct 543 VWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGF 602 Query 1109 GIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELAD 1168 GIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELAD Sbjct 603 GIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELAD 662 Query 1169 QAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL 1228 QAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL Sbjct 663 QAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL 722 Query 1229 ESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAAVWGLVRSA 1288 ESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAAVWGLVRSA Sbjct 723 ESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAAVWGLVRSA 782 Query 1289 QAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGW 1348 QAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGW Sbjct 783 QAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGW 842 Query 1349 RLVAGGAGALEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGA 1408 RLVAGGAG LEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGA Sbjct 843 RLVAGGAGTLEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGA 902 Query 1409 GVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAY 1468 GVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAY Sbjct 903 GVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAY 962 Query 1469 YALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTH 1528 YALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTL TM CDNTH Sbjct 963 YALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLQTMRCDNTH 1022 Query 1529 VADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRS 1588 VADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRS Sbjct 1023 VADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRS 1082 Query 1589 LPRTILGWPTGLST 1602 LPRTILGWPTGLST Sbjct 1083 LPRTILGWPTGLST 1096 >gi|289443120|ref|ZP_06432864.1| polyketide synthase pks8 [Mycobacterium tuberculosis T46] gi|289416039|gb|EFD13279.1| polyketide synthase pks8 [Mycobacterium tuberculosis T46] Length=1042 Score = 2034 bits (5271), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1038/1042 (99%), Positives = 1039/1042 (99%), Gaps = 0/1042 (0%) Query 561 VFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTE 620 +FVFPGQ AQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTE Sbjct 1 MFVFPGQRAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTE 60 Query 621 FAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLM 680 FAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLM Sbjct 61 FAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLM 120 Query 681 AELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRR 740 AELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRR Sbjct 121 AELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRR 180 Query 741 VHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEH 800 VHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEH Sbjct 181 VHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEH 240 Query 801 ARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSV 860 ARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSV Sbjct 241 ARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSV 300 Query 861 LGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAAR 920 LGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAAR Sbjct 301 LGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAAR 360 Query 921 HGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCG 980 HGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCG Sbjct 361 HGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCG 420 Query 981 VVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKA 1040 VVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKA Sbjct 421 VVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQRPVSIYSRNAESDSGWVLHARGVLGAKA 480 Query 1041 VAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDD 1100 VAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDD Sbjct 481 VAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDD 540 Query 1101 VDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDG 1160 VDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDG Sbjct 541 VDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDG 600 Query 1161 TVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDIS 1220 TVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDIS Sbjct 601 TVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDIS 660 Query 1221 ADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAA 1280 ADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAA Sbjct 661 ADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSVGQDATNLAGAA 720 Query 1281 VWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQ 1340 VWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQ Sbjct 721 VWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQ 780 Query 1341 LPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGA 1400 LPDTNSGWRLVAGGAG LEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGA Sbjct 781 LPDTNSGWRLVAGGAGTLEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGA 840 Query 1401 AELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGV 1460 AELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGV Sbjct 841 AELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGV 900 Query 1461 PVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLH 1520 PVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTL Sbjct 901 PVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLQ 960 Query 1521 TMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGK 1580 TMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGK Sbjct 961 TMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGK 1020 Query 1581 TEFGTPRSLPRTILGWPTGLST 1602 TEFGTPRSLPRTILGWPTGLST Sbjct 1021 TEFGTPRSLPRTILGWPTGLST 1042 >gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342131778|gb|EGT85035.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=2121 Score = 2030 bits (5259), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1087/1596 (69%), Positives = 1248/1596 (79%), Gaps = 19/1596 (1%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 M GT+ HVDYLKRLTADLRRTRRR+++LE +L EPVAVVGM CRY GGV+SPE LW+LV Sbjct 1 MPGTSQHVDYLKRLTADLRRTRRRVAELEGQLFEPVAVVGMACRYAGGVESPEDLWQLVI 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 +GRD VSDFPADRGWDV+GL+DPDPDA GKMYTR+G+FL+ AGDFDAGFFGIGPSEALAM Sbjct 61 EGRDTVSDFPADRGWDVEGLYDPDPDAKGKMYTRQGSFLQDAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQR++LE+ WEALER GIDP LRGSATGVFAGVIHAGYGG++ GELEGYGLTGSTLS Sbjct 121 DPQQRMMLEICWEALERAGIDPFALRGSATGVFAGVIHAGYGGEVKGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 V SGRV+YVLGLEGPAVSVDTACSSSLV++HLA QSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VTSGRVSYVLGLEGPAVSVDTACSSSLVSMHLAAQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALA DGRCKVYAGAADGT+WSEGAGVLV+ERL DARRLGHPVLA++RG+AVNQD Sbjct 241 EFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVLAVLRGTAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALA+A L A +VDVVEGHGTGT+LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALANAGLAAADVDVVEGHGTGTVLGDPIEAQALLATYGQD 360 Query 361 RV--EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAV 418 R PLWLGSIKSNIGHTSAAAGVAGVIKMVQA+RHGVMPKTLHVDVP+PHVDW+ GAV Sbjct 361 RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAIRHGVMPKTLHVDVPSPHVDWTSGAV 420 Query 419 SLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPV-VESVVPEVASPTAASAVPWV 477 SLLT+P+ W HG RRAGVSSFGISGTNAHVI+EQAP ++S VA P+ +PWV Sbjct 421 SLLTEPQPWPDHGGIRRAGVSSFGISGTNAHVIVEQAPAQLDSDAEPVAGPS-NPVIPWV 479 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SARS +ALAGQAQRLL ++A+ D +DVGWSL RA FEHRAV++G DR AL GL Sbjct 480 ISARSPEALAGQAQRLLDRLSADADARAVDVGWSLATNRAAFEHRAVLIGRDREALTTGL 539 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 A LA+G G VGR R GK VFVFPGQG+Q +GMGA+LY P FA AFD +D Sbjct 540 AGLASGRPDPGALVGRTRPAGKRVFVFPGQGSQSLGMGAELYDRFPAFAQAFDEAVAAVD 599 Query 598 RHLRLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAA 657 H RLPLR V+W D LL STEFAQPALF +E+ALA L Q +GI+PD +IGHSVGEIAA Sbjct 600 AHARLPLREVMWGTDPELLQSTEFAQPALFVVEIALAALWQSFGITPDVVIGHSVGEIAA 659 Query 658 AHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHS 717 A +AG + L DAA LVAARGRLMA LPAGGVMV V+A+E EV +L ++AAVN P S Sbjct 660 ACVAGAMPLPDAARLVAARGRLMAGLPAGGVMVAVSATEAEVAGLLNGAVSIAAVNGPRS 719 Query 718 VVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIP 777 +V+SG AV +AD A G RVHRLAVSHAFHS LMEPM+ EF +AAG+S +PRI Sbjct 720 LVLSGERDAVGAVADRLAAGGARVHRLAVSHAFHSPLMEPMMGEFAAVAAGVSAGQPRIA 779 Query 778 LVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQ 837 LVSN+TGQ+AG YG YWV+H R+PVRF +GVQL ++GA F+EVGPG LT+ VEQ Sbjct 780 LVSNLTGQLAGPDYGTAGYWVDHVRKPVRFVDGVQLAESLGAGVFLEVGPGAALTSAVEQ 839 Query 838 SLPLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSP-GRRIELPTYAFQR 896 SL A SV M ++ PEV S+L A LFTAGA + W A F RR+ELPTYAF R Sbjct 840 SLTTERATSVVSMAKDRPEVDSLLRAAGQLFTAGADVRWAAAFADGWARRVELPTYAFVR 899 Query 897 QRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIA 956 +R+WL S GSA+I+ +GL A H LLGAVV++PDS VVLTGRLS+ Q WLADH +A Sbjct 900 RRFWLSSDSVGSANIASLGLAEAEHALLGAVVDRPDSGGVVLTGRLSIAAQPWLADHAVA 959 Query 957 GVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPV 1015 G VL GA FVELALRA D+V C VVEELT+ PLV+P G V LQVVV G G+ G R V Sbjct 960 GTVLFPGAGFVELALRAGDEVGCSVVEELTLAAPLVVPAAGVVHLQVVVAGAGDAGTRTV 1019 Query 1016 SIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYG 1075 ++YSR A+SD WVLHA GVL A AP DLSVWPP GA VDV GAY A GY YG Sbjct 1020 TVYSRAAQSD--WVLHAEGVLSGGAPAPDTDLSVWPPPGADAVDVTGAYDGLAGRGYGYG 1077 Query 1076 RAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPF 1135 AF+GL +WRR +E FA+V +P+ V GFGIHP++LDAALHA+G+ E+ T+LPF Sbjct 1078 PAFRGLRTVWRRGTETFAEVELPEQAGVATGGFGIHPVLLDAALHALGVADERIETVLPF 1137 Query 1136 SWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVA 1195 SWQGV L+AAGASRVR R+AP G G VSVELAD +GLPVLSV+ LV R+VS+ L+AAVA Sbjct 1138 SWQGVCLNAAGASRVRVRLAPVGAGAVSVELADSSGLPVLSVRELVTRAVSADQLAAAVA 1197 Query 1196 AADAAGRGLLEVAWLPVELAHNDISADLVVWELESFQDG-VGPVYSATHRVLVALQSWLA 1254 A +G LL+V W PV ND+ +D+ VWE G VG VY ATH L LQSWL Sbjct 1198 ARSGSGE-LLDVVWSPVSPPGNDVGSDITVWESPPAGPGAVGSVYRATHEALGVLQSWLT 1256 Query 1255 QERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVI 1311 E+AG LVVLT+G+V G+D +LAGAAVWGL RSAQAEHPGRV+LVD+DG++DV VI Sbjct 1257 AEQAGVLVVLTRGAVGLAGEDVADLAGAAVWGLTRSAQAEHPGRVVLVDTDGTLDVAAVI 1316 Query 1312 -GCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKE 1370 GCGE QL++R+G AY+ARL +P+L+LPD S WRL AG AG LEDL + P Sbjct 1317 GGCGEPQLVVRDGVAYSARLKPADQRPLLRLPDPPSAWRLAAGDAGTLEDLAVQEYPPAA 1376 Query 1371 LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGL 1430 L GQVR+ V A GVNFRDVLVALG+YPGAA+LGAEGAG+VTE+G GV LAVGD VMG+ Sbjct 1377 LESGQVRVTVAAAGVNFRDVLVALGMYPGAAQLGAEGAGIVTELGAGVADLAVGDAVMGI 1436 Query 1431 LGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAG 1490 G+AGSEA VD RLV ++P W + AA VPVVFLTAYY L VLA ++ G+ VLVHAA G Sbjct 1437 FGLAGSEAAVDRRLVTRVPRGWSMAQAAAVPVVFLTAYYGLSVLAGLRAGQRVLVHAATG 1496 Query 1491 GVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGV 1550 GVGMAAVQLAR WG EVFATASRGKWDTL MG D+ H+ADSRTL FE+ F G+ Sbjct 1497 GVGMAAVQLARHWGAEVFATASRGKWDTLRVMGFDDAHIADSRTLDFEQKF-----AGGM 1551 Query 1551 DVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 DVVLNSLAGEF DASLRLL GGRFIEMGKT+ P Sbjct 1552 DVVLNSLAGEFNDASLRLLGPGGRFIEMGKTDLRDP 1587 >gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118163848|gb|ABK64745.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=2128 Score = 2029 bits (5257), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1096/1606 (69%), Positives = 1254/1606 (79%), Gaps = 21/1606 (1%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 M GT H+DYLKRLTADLRRTRRR+++LE +LSEPVAVVGM CRY GGVDSPE LW+LV Sbjct 1 MPGTEQHLDYLKRLTADLRRTRRRVAELEGRLSEPVAVVGMACRYAGGVDSPEALWDLVI 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 +GRD VSDFP DRGWDV+GL+DPDPDA GKMYTR+G+FL+HAGDFDAGFFGIGPSEALAM Sbjct 61 EGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQGSFLQHAGDFDAGFFGIGPSEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQR++LE+ WEALER GIDP+ LRG+ATGVFAGVIHAGYGG++ GELEGYGLTGSTLS Sbjct 121 DPQQRIMLEICWEALERAGIDPSALRGTATGVFAGVIHAGYGGEVKGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 V SGRV+YVLGLEGPAVSVDTACSSSLVA+HLA QSLRSGECDLALAGGVTVMATPAAFV Sbjct 181 VTSGRVSYVLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALA DGRCKVYAGAADGT+WSEGAGVLV+ERL DARRLGHPV A++RGSAVNQD Sbjct 241 EFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWAVLRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALA+A L AV+VDVVEGHGTGT+LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTGTVLGDPIEAQALLATYGQD 360 Query 361 RV--EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAV 418 R PLWLGSIKSNIGHTSAAAGVAGVIKMVQA+RHGVMPKT+HVDVP+PHVDWS GAV Sbjct 361 RPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQALRHGVMPKTMHVDVPSPHVDWSAGAV 420 Query 419 SLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASA-VPWV 477 SLLT PR W HG PRRAGVSSFGISGTNAHVI+EQAP AS T A VPWV Sbjct 421 SLLTDPRPWPEHGGPRRAGVSSFGISGTNAHVIVEQAPAAAETEAAPASSTMPDAVVPWV 480 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SARS +ALAGQA+RLL V A+ P+DVGWSLV TRA+FEHRAVVVG +RGAL GL Sbjct 481 VSARSAEALAGQARRLLDHVTADAQASPLDVGWSLVSTRAVFEHRAVVVGRERGALATGL 540 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 A LA+G G VGRARS GKTV VFPGQG+Q +GMG QLY +FA A D +D Sbjct 541 AGLASGRPGPATVVGRARSTGKTVLVFPGQGSQTLGMGRQLYERFEVFAGALDEAVAVVD 600 Query 598 RHLRLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAA 657 H RL +R V+W D LL STEFAQPALF EVALA L + G++PD ++GHSVGEIAA Sbjct 601 EHSRLSVREVMWGADPELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAA 660 Query 658 AHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHS 717 A +AGVLSL DAA LVAARG LMA LP GGVMV V A E +V P+L G ++AAVN P + Sbjct 661 ACVAGVLSLRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGGVSIAAVNGPDA 720 Query 718 VVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIP 777 VV+SG + AV+ +AD A G RVHRLAVSHAFHS LMEPML F AAGI PRIP Sbjct 721 VVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAGIEPRPPRIP 780 Query 778 LVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQ 837 LVSN+TGQ+AG GYG QYWV+H RRPVRF +GV+L + GA F+EVGPG LT+ VEQ Sbjct 781 LVSNLTGQLAGPGYGTPQYWVDHVRRPVRFVDGVRLAESQGAGVFLEVGPGAALTSAVEQ 840 Query 838 SLPLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQR 896 SL A+SV M + PEV S+L A A LFTAGA + W A F G RR++LPTYAF R Sbjct 841 SLTSDRAMSVVTMPKGRPEVDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFAR 900 Query 897 QRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIA 956 +R+WL + GSA+I+ +GL A H LLGAV+++PDS VVLTGRLS Q WLADH +A Sbjct 901 RRFWLSGDAVGSANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQPWLADHAVA 960 Query 957 GVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV--GVGEMGQRP 1014 G VL GA FVELALRA D+V C VVEELT+ PL LP G VQLQVVV G+ G R Sbjct 961 GTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVVADAAGQPGSRS 1020 Query 1015 VSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEY 1074 V++YSR A+S+ W LHA GVL A APAA+LSVWPP A VDV G Y A GY Y Sbjct 1021 VAVYSRVAQSE--WTLHAEGVLSEAAPAPAAELSVWPPADAEAVDVAGGYDDLAGRGYGY 1078 Query 1075 GRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLP 1134 G AF+GL A+WRR +E FA+V +P+ V+ FGIHP++LDAALHA+G+ ++ T+LP Sbjct 1079 GPAFRGLRAVWRRGAETFAEVELPEQAGVSTGRFGIHPVLLDAALHALGVADKRLETVLP 1138 Query 1135 FSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAV 1194 FSWQGVSLHAAGASRVR R+APAG G VSVELAD +G+PVLSV+ LV R+VS++ L+AAV Sbjct 1139 FSWQGVSLHAAGASRVRVRLAPAGAGAVSVELADASGVPVLSVRELVTRAVSAEQLAAAV 1198 Query 1195 AAADAAGRGLLEVAWLPVE----LAHNDISADLVVWELESFQDGVGP--VYSATHRVLVA 1248 A +G LL+VAW +E L N IS + VWE + DG GP V++ATH+ L Sbjct 1199 AVRSGSGE-LLDVAWSVIEPRNSLPDNPISEGVTVWEPAAV-DGAGPAAVHAATHQALGV 1256 Query 1249 LQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSM 1305 LQS LA E G LVV T+G+V G+D +LAGAAVWGLVRSAQAEHPGRV+LVD+DGS+ Sbjct 1257 LQSRLAGEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQAEHPGRVVLVDTDGSL 1316 Query 1306 DVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLAS 1365 D+ VIGCGE QL++R+G AY ARL + +L+LP + WRL AG AG LEDL + Sbjct 1317 DLATVIGCGEPQLVVRDGVAYRARLRPAGRRALLELPGPPAVWRLAAGDAGTLEDLAVQE 1376 Query 1366 CPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGD 1425 PA ELAPGQVR+ V A GVNFRDVLVALG+YPGAA+LGAEGAGVVTEVG GVT +AVGD Sbjct 1377 HPAAELAPGQVRVRVAAAGVNFRDVLVALGMYPGAAQLGAEGAGVVTEVGAGVTDVAVGD 1436 Query 1426 PVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLV 1485 VMG+ G+ GSEA VD RLV ++P W + AAG+PVVFLTAYY L VLA ++ G+ VLV Sbjct 1437 AVMGIFGLVGSEAAVDRRLVTRVPPGWSMAQAAGIPVVFLTAYYGLSVLAGLRAGQRVLV 1496 Query 1486 HAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTT 1545 HAA GGVGMAAVQLAR WG EVFATASRGKWDTL MG D+ H+ADSRTL FE+ F Sbjct 1497 HAATGGVGMAAVQLARHWGAEVFATASRGKWDTLRAMGFDDAHIADSRTLDFEQKFGAAP 1556 Query 1546 EGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRSLPR 1591 G+DVVLNSLAGEF DASLRLL GGRFIEMGKT+ P + R Sbjct 1557 G--GMDVVLNSLAGEFNDASLRLLGPGGRFIEMGKTDLRDPDVVAR 1600 >gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=2131 Score = 1997 bits (5173), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1071/1594 (68%), Positives = 1238/1594 (78%), Gaps = 12/1594 (0%) Query 3 GTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQG 62 GT HVDYLKRLTADLRRTRRR+++LE +LSEPVAVVGM CRY GGVD+P+ LWELVA+G Sbjct 16 GTAQHVDYLKRLTADLRRTRRRVAELEGQLSEPVAVVGMACRYAGGVDTPDALWELVAEG 75 Query 63 RDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDP 122 RD VSDFP DRGWDV+GL+DPDPDA GKMYTR G+FL+HAGDFDAGFFGIGPSEALAMDP Sbjct 76 RDTVSDFPLDRGWDVEGLYDPDPDAKGKMYTRHGSFLQHAGDFDAGFFGIGPSEALAMDP 135 Query 123 QQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVA 182 QQR++LE+ WEALER GIDP LRG+ATGVFAGVIHAGYGG++ GELEGYGLTGSTLSV Sbjct 136 QQRMMLEICWEALERAGIDPFALRGTATGVFAGVIHAGYGGEVKGELEGYGLTGSTLSVT 195 Query 183 SGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEF 242 SGRV+YVLGLEGPAVSVDTACSSSLV++HLA QSLRSGECDLALAGGVTVMATPAAFVEF Sbjct 196 SGRVSYVLGLEGPAVSVDTACSSSLVSMHLAAQSLRSGECDLALAGGVTVMATPAAFVEF 255 Query 243 SRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGA 302 SRQRALA DGRCKVYAGAADGT+WSEGAGVLV+ERL DARRLGHPVLAL+RG+AVNQDGA Sbjct 256 SRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVLALLRGTAVNQDGA 315 Query 303 SNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRV 362 SNGLTAPNGPSQQRVIRAALA+A L A +VD VEGHGTGT+LGDPIEAQALLATYGQDR Sbjct 316 SNGLTAPNGPSQQRVIRAALANAGLTAADVDAVEGHGTGTVLGDPIEAQALLATYGQDRP 375 Query 363 --EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+P+TLHVDVP+PHVDWS GAVSL Sbjct 376 ADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPRTLHVDVPSPHVDWSAGAVSL 435 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSA 480 LT PR W HG PRRAGVSSFGISGTNAHVI+EQAP + VP A + VPWV+SA Sbjct 436 LTDPRPWPDHGGPRRAGVSSFGISGTNAHVIVEQAPAEPNDVP-AAHDGSNPIVPWVVSA 494 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RS ALAGQAQRLL + A PD+ +DVGWSL TRA FEHRAV++GADR L AGLA L Sbjct 495 RSTDALAGQAQRLLDHLGATPDVPAVDVGWSLATTRAAFEHRAVLIGADRAGLSAGLAGL 554 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAG G GR R+ GK VFVFPGQG+QW+GMGA LY P FA AFD +D H Sbjct 555 AAGAPVPGAITGRTRAAGKRVFVFPGQGSQWLGMGAALYERFPAFAQAFDETETAVDAHC 614 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLR V+W D LL STEFAQPALFA+E+A+A L + G++PD +IGHSVGEIAAA + Sbjct 615 RLPLREVMWGSDAELLQSTEFAQPALFALEIAMAALWESLGVTPDVVIGHSVGEIAAACV 674 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AG LSL+DAA LVA+RGRLMA+LP GGVM+ V A+E +V P+L +AAVN P S+V+ Sbjct 675 AGALSLSDAARLVASRGRLMAQLPPGGVMMAVTATEADVAPLLNGDVGIAAVNGPQSLVL 734 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SG E+AV +AD A G RV +LAVSHAFHS LMEPM+ +F + AG+S +PRI LVS Sbjct 735 SGSESAVKVVADRLAAGGARVRQLAVSHAFHSPLMEPMMGDFAAVVAGVSAREPRIALVS 794 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 N+TGQ+AG YG YWV+H R+PVRF +GVQL ++GA F+EVGPG +TA V+Q L Sbjct 795 NLTGQLAGPDYGTVAYWVDHVRKPVRFVDGVQLAESLGAGVFLEVGPGAAMTAAVDQCLT 854 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRY 899 A+SV M + PEV S+L A LF G+ +DW A F G RRI LPTYAF R+R+ Sbjct 855 TDRAMSVVSMAKGRPEVDSLLSAAGQLFATGSDLDWSAAFTGLSARRIPLPTYAFVRRRF 914 Query 900 WLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVV 959 WL S GSA+I+ +GL A H LLGAVV++PDS VVLTGRLS Q WL DH +AG V Sbjct 915 WLSSDSVGSANIASLGLTEAEHALLGAVVDRPDSGGVVLTGRLSTAAQPWLGDHAVAGTV 974 Query 960 LLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGE-MGQRPVSIY 1018 L GA FVELALRA D+V C V+EELT+ PL +P G VQLQVVV + G R VS+Y Sbjct 975 LFPGAGFVELALRAGDEVGCSVIEELTLSAPLAVPVGGVVQLQVVVEAADGTGARAVSVY 1034 Query 1019 SRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAF 1078 SR A++D W+LHA G+L A P DLSVWPP+GA VDV GAY A+ GY YG AF Sbjct 1035 SRAAQTD--WILHAEGLLRDGATTPVTDLSVWPPVGAEAVDVAGAYDGLADRGYGYGPAF 1092 Query 1079 QGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSWQ 1138 QGL A+WRR +E FA+V +P V GFGIHP++LDAALHA+G+ E+ T+LPFSWQ Sbjct 1093 QGLRAVWRRGAETFAEVELPQHAGVATGGFGIHPVLLDAALHALGVADERIETVLPFSWQ 1152 Query 1139 GVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAAD 1198 GVSL+AAGASRVR R+APAG G VSV+LAD +GLPVLSV+ LV R+VS+ L AA+AA Sbjct 1153 GVSLYAAGASRVRVRLAPAGTGAVSVDLADASGLPVLSVRELVTRAVSADQLRAALAARA 1212 Query 1199 AAGRGLLEVAWLPVELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQERA 1258 +G LL+V W P+ L N + + VWE + VY+A H L LQSWL+ + A Sbjct 1213 GSGE-LLDVVWSPISLPGNGVGQGVTVWEPPPGAS-ITAVYTAAHEALGVLQSWLSGDAA 1270 Query 1259 GRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGE 1315 G LVV T+G+V D ++LAGAAVWGLVRSAQAEHPGR++LVD+DGS+DV VIGCGE Sbjct 1271 GTLVVQTRGAVTLSADDVSDLAGAAVWGLVRSAQAEHPGRIVLVDTDGSLDVATVIGCGE 1330 Query 1316 EQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQ 1375 QL++R+G A++ARL + +L LP+ S WRL AG AG LEDL + P EL GQ Sbjct 1331 PQLVVRDGIAHSARLKPAGQRALLSLPEPPSVWRLAAGDAGTLEDLAVQEYPPAELEAGQ 1390 Query 1376 VRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAG 1435 VR+ V A GVNFRDVLVALG+YPGAA+LGAEGAG+VTEVG GVT +AVGD VMG+ G+AG Sbjct 1391 VRVAVAAAGVNFRDVLVALGMYPGAAQLGAEGAGIVTEVGSGVTDVAVGDAVMGIFGLAG 1450 Query 1436 SEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMA 1495 SEA VD RLV ++P W + AAGVPVVFLTAYY L VLA ++ G+ VLVHAA GGVGMA Sbjct 1451 SEATVDRRLVTRVPRGWSMAQAAGVPVVFLTAYYGLSVLAGLRAGQRVLVHAATGGVGMA 1510 Query 1496 AVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLN 1555 AVQLAR WG EVFATASRGKWDTL MG D+ H+ADSRTL FE F G VVLN Sbjct 1511 AVQLARHWGAEVFATASRGKWDTLRAMGFDDAHIADSRTLEFEHKFRAAVGAGGFGVVLN 1570 Query 1556 SLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRSL 1589 SLAGEF DASLRLL RGGRFIEMGKT+ P ++ Sbjct 1571 SLAGEFNDASLRLLGRGGRFIEMGKTDLRDPDAV 1604 >gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Mycobacterium marinum M] gi|183175812|gb|ACC40922.1| polyketide synthase, Pks8 [Mycobacterium marinum M] Length=2114 Score = 1962 bits (5083), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1087/1599 (68%), Positives = 1242/1599 (78%), Gaps = 21/1599 (1%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 M+ TT HVDYLKRLTADLRRTRRR+++LE KLSEPVA+VGMGCRYPGG DSPE+LWE++ Sbjct 1 MTETTKHVDYLKRLTADLRRTRRRVAELEDKLSEPVALVGMGCRYPGGADSPESLWEMLT 60 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 QGRDAVS+FP+DRGWD+D +FDPDPDA GK YTRRG FL AGDFDAGFFG+GP+EALAM Sbjct 61 QGRDAVSEFPSDRGWDIDAMFDPDPDARGKTYTRRGGFLADAGDFDAGFFGVGPNEALAM 120 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQRL+LEVSWEALER+GIDPT LRGSATGVF GVIHAGYGG++ GELEGYGLTGSTLS Sbjct 121 DPQQRLMLEVSWEALERSGIDPTTLRGSATGVFVGVIHAGYGGEVKGELEGYGLTGSTLS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLA QSLRS ECDLAL GGVTVMATPAAFV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAAQSLRSRECDLALVGGVTVMATPAAFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALA DG CK YAGAADGT WSEGAGVLVVERL DA+RLGHPVLA+VRGSAVNQD Sbjct 241 EFSRQRALAADGLCKAYAGAADGTTWSEGAGVLVVERLADAQRLGHPVLAVVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALASARL +VDVVEGHGTGT+LGDPIEAQA+LATYGQD Sbjct 301 GASNGLTAPNGPSQQRVIRAALASARLGVADVDVVEGHGTGTVLGDPIEAQAILATYGQD 360 Query 361 RVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSL 420 R EPLWLGSIKSNIGHTSAAAGVAG+IKMV AM+HGV+P+TLHVDVPTPHVDWS GAVSL Sbjct 361 RTEPLWLGSIKSNIGHTSAAAGVAGLIKMVLAMQHGVLPQTLHVDVPTPHVDWSAGAVSL 420 Query 421 LTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVV--PEVASPTAASAVPWVL 478 LT+ R W GRPRRAGVSSFGISGTNAHVILEQAP E + P+ +PT VPWVL Sbjct 421 LTESRPWPDLGRPRRAGVSSFGISGTNAHVILEQAPTAEHDLAEPDRGAPT----VPWVL 476 Query 479 SARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLA 538 SARS ALA QAQRLL++ +PDLDP+DVGWSL TR++FEHRAVVVG DR L+ GLA Sbjct 477 SARSAPALANQAQRLLSWAEEHPDLDPVDVGWSLAATRSLFEHRAVVVGTDRTQLMDGLA 536 Query 539 ALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDR 598 + AGE GAGV VGRARS GKTVFVFPGQGAQ++GMG LY F+ AFDA A ELD Sbjct 537 GVVAGEPGAGVVVGRARSTGKTVFVFPGQGAQYLGMGRVLYERFSAFSTAFDAAAAELDA 596 Query 599 HLRLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAA 658 HLRLPLR V+W DE LL STEFAQPALFA+EVALA LL G+ PD ++GHSVGEI+AA Sbjct 597 HLRLPLRQVMWGTDEGLLESTEFAQPALFAVEVALAALLSQLGVVPDLVLGHSVGEISAA 656 Query 659 HLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSV 718 H+AGVLSL DAA LVAARGRLMA L AGG MV VAASE+EV P+L G +AAVN P SV Sbjct 657 HVAGVLSLPDAARLVAARGRLMAGLAAGGAMVAVAASEQEVTPLLGSGVAVAAVNGPDSV 716 Query 719 VVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPL 778 V+SG EAAV ++ D A GRR HRLAVSHAFHS LM+PML +F + G+S S+PRI L Sbjct 717 VISGPEAAVGEVVDRIAALGRRTHRLAVSHAFHSELMDPMLPDFAEVLKGVSASQPRISL 776 Query 779 VSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQS 838 VSNVTGQ+A AGYG YWVEH R+PVRFA+ V L ++GA FVEVGP GGLTALVEQS Sbjct 777 VSNVTGQLAEAGYGSAAYWVEHVRKPVRFADSVALAESLGAAAFVEVGPSGGLTALVEQS 836 Query 839 LPLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPG-RRIELPTYAFQRQ 897 L E +V ++ ++ PE ++L + LF G +DW F G +R +LPTY F R+ Sbjct 837 LTR-ETPAVPLLIKDRPENDALLLGLGQLFADGRALDWREAFAGLGAQRTDLPTYGFVRR 895 Query 898 RYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAG 957 RYWL ++G GL H LLGAVVE+PD +VLTG LS WL DH + G Sbjct 896 RYWLKELGVDQTKLTGAGLTGVGHPLLGAVVERPDVGGLVLTGVLSPELHPWLRDHTVDG 955 Query 958 VVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVS 1016 VVL GA FVELALRA D+V C +V+ELT++ PL LP G V++Q+VV G E G+R VS Sbjct 956 VVLFPGAGFVELALRAGDEVGCPLVQELTLLAPLALPQTGTVRMQLVVGGADESGRRTVS 1015 Query 1017 IYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGR 1076 ++S A+ DS WVLHA GVL A V DLSVWPP+GA+ VDV Y RFA GY YG Sbjct 1016 VFSSTADGDS-WVLHAEGVLRASGVGHGVDLSVWPPVGASAVDVSDVYDRFAARGYGYGP 1074 Query 1077 AFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFS 1136 AF+GL ++WRR E++A+V P+ D T+ GFGIHP VLDAALHA G MLPFS Sbjct 1075 AFRGLRSVWRRGREIYAEVVAPE--DATVQGFGIHPAVLDAALHAWGFATATDQLMLPFS 1132 Query 1137 WQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAA 1196 WQGVSLHAAGA+R+R RI PA G+VS+ELAD GLPVLSV+ LV+R+VS + LSAAV A Sbjct 1133 WQGVSLHAAGAARLRVRITPADAGSVSLELADPRGLPVLSVKQLVVRAVSGEALSAAVIA 1192 Query 1197 ADAAGRG-LLEVAWLPV--ELAHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWL 1253 A G LLEVAW P EL+ +D + D+VVWE S DG V + L LQSWL Sbjct 1193 AGGTISGRLLEVAWPPTSPELSASDSARDVVVWESGS-ADGDVAVGQRVNEALAKLQSWL 1251 Query 1254 AQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDV 1310 A + G LVVLT+G+V G+ T+LAGAAVWGL RSAQAEHPGRV+LVD+D S+D+ D Sbjct 1252 AGDDPGVLVVLTRGAVGLAGEGVTDLAGAAVWGLTRSAQAEHPGRVVLVDTDDSVDIADA 1311 Query 1311 IGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKE 1370 + CGE QL++R+G + ARL + L+LP+ WRL GG G LED+ + CP + Sbjct 1312 VACGEPQLVVRSGVVHGARLRFIDSGSGLELPE--GPWRLAVGGGGTLEDVLVQPCPRAD 1369 Query 1371 LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGL 1430 LA GQVR+ V A GVNFRDVLVALG+YPG LGAEGAGVV EVGPGV GLAVGD VMGL Sbjct 1370 LAAGQVRVAVGAAGVNFRDVLVALGMYPGGGALGAEGAGVVVEVGPGVEGLAVGDAVMGL 1429 Query 1431 LGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAG 1490 +GV GSEAVVD RLV +P W L AAGVPVVFLTA+Y L VLA ++ GE VL+HA AG Sbjct 1430 VGVVGSEAVVDERLVTTVPAGWSLAQAAGVPVVFLTAFYGLSVLAGLKAGERVLIHAGAG 1489 Query 1491 GVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGV 1550 GVGMAAV LA+ WG E+F TASRGKWDTL MG D+ H+ DSR+L FEE F T+ G GV Sbjct 1490 GVGMAAVALAKYWGAEIFVTASRGKWDTLRAMGFDDEHIGDSRSLEFEEKFRKTSGGAGV 1549 Query 1551 DVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRSL 1589 DVVLNSLAGEFTDASLRLL GGRFIEMGKT+ P+++ Sbjct 1550 DVVLNSLAGEFTDASLRLLVSGGRFIEMGKTDLRDPQAV 1588 >gi|296164561|ref|ZP_06847131.1| erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295900085|gb|EFG79521.1| erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] Length=2122 Score = 1943 bits (5033), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1099/1599 (69%), Positives = 1241/1599 (78%), Gaps = 16/1599 (1%) Query 1 MSGTTTHVDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 M TT HVDYLKRLTADLRR RRR+++LE KLSEP+AVVGM CRY GGVDSPE LW+LV Sbjct 10 MPDTTQHVDYLKRLTADLRRARRRVAELEGKLSEPIAVVGMACRYAGGVDSPEALWQLVN 69 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 GRD VSDFPADRGWDV+GL+DPDPDA GKMYTR+G+FL AGDFDAGFFGIGPSEALAM Sbjct 70 DGRDTVSDFPADRGWDVEGLYDPDPDAAGKMYTRQGSFLRDAGDFDAGFFGIGPSEALAM 129 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQQR++LE+SWEALER GIDP LRGSATGVFAGVIHAGYGG++ GELEGYGLTGSTLS Sbjct 130 DPQQRVMLEISWEALERAGIDPLGLRGSATGVFAGVIHAGYGGEVKGELEGYGLTGSTLS 189 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRV+YVLGLEGPAVSVDTACSSSLVA+HLA QSLRSGECDLALAGGVTVMATPAAFV Sbjct 190 VASGRVSYVLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFV 249 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSRQRALA DGRCKVYAGAADGT+WSEGAGVLV+ERL DARRLGHPVLA++RGSAVNQD Sbjct 250 EFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVLAVLRGSAVNQD 309 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRVIRAALA A L A +VDVVEGHGTGT+LGDPIEAQALLATYGQD Sbjct 310 GASNGLTAPNGPSQQRVIRAALADAGLTAADVDVVEGHGTGTVLGDPIEAQALLATYGQD 369 Query 361 RV--EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAV 418 R PLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+P+TLHVDVP+PHVDWSVGAV Sbjct 370 RPPGRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVIPRTLHVDVPSPHVDWSVGAV 429 Query 419 SLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAAS--AVPW 476 SLLT+P+ W RRAGVSSFGISGTNAHVI+E+ P VA+ T S VPW Sbjct 430 SLLTEPQPWPARDGGRRAGVSSFGISGTNAHVIVEEPPAEPETPEAVAAQTDDSRPVVPW 489 Query 477 VLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAG 536 V+SARS ALA QA RL A++ A P L P DVGWSL TRA EHRAV+VG+DR L AG Sbjct 490 VVSARSADALAAQAARLSAYLDAEPGLRPRDVGWSLATTRAALEHRAVLVGSDRDTLRAG 549 Query 537 LAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEEL 596 LA +A+GE G G VGR+RS GK FVFPGQGAQ +GMG +L+ P FA AFD + Sbjct 550 LAGVASGEPGPGAVVGRSRSTGKRAFVFPGQGAQRLGMGRELHQRFPAFAEAFDEAVAAV 609 Query 597 DRHLRLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 D H R PLR V+W D LL STEFAQPALF +EVALA L + WG++PD +IGHSVGEIA Sbjct 610 DAHARRPLREVMWGTDPELLQSTEFAQPALFVLEVALAALWRSWGVTPDVVIGHSVGEIA 669 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPH 716 AAH+AGVLSL DAA LVAARGRLMA LP GGVMV V A+E EV P+L G +LAAVN P Sbjct 670 AAHVAGVLSLRDAARLVAARGRLMAALPPGGVMVAVTATEAEVAPLLDGGVSLAAVNGPA 729 Query 717 SVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRI 776 +VV+SG AV+ AD A GRRV +LAVSHAFHS LMEPM+ EF+ +AAG+S PRI Sbjct 730 AVVLSGERDAVTAAADRLADCGRRVRQLAVSHAFHSPLMEPMIEEFSAVAAGVSPGSPRI 789 Query 777 PLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVE 836 LVSNVTG+ AG GYG YWVEH RRPVRFA+G + A+GA FVEVGPG LTA VE Sbjct 790 DLVSNVTGRPAGPGYGSADYWVEHVRRPVRFADGARCAAALGAGAFVEVGPGAALTAAVE 849 Query 837 QSLPLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDW-PAVFGSPGRRIELPTYAFQ 895 QSL A++ M ++HPEV S+L A LF +GA +DW A G R++LPTYAF Sbjct 850 QSLGAEPAVAAVSMAKDHPEVDSLLLAAGQLFASGADLDWAAAFAGLAAHRVDLPTYAFA 909 Query 896 RQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVI 955 R+R+WL S G D +G+GL AA H LLGAVVE+PDS VVLTGRLS Q WLADH + Sbjct 910 RRRFWLLSESVGGRDTAGLGLAAAGHALLGAVVERPDSGGVVLTGRLSTVAQPWLADHAV 969 Query 956 AGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRP 1014 AG VL GA FVEL LRA D+V C V+EEL + PL LP G V +QVVV G GE G R Sbjct 970 AGTVLFPGAGFVELMLRAGDEVGCPVIEELMLSAPLPLPAAGAVCVQVVVDGAGEGGSRA 1029 Query 1015 VSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEY 1074 ++YS ++ S W LHA+GVLG + AP ADLSVWPP+GA VDV GAY A GY Y Sbjct 1030 AAVYS---QAGSQWTLHAQGVLGEGSPAPDADLSVWPPVGATAVDVAGAYDDLAGRGYGY 1086 Query 1075 GRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLP 1134 G AF+GL A+WRR +E+FA+V P D V + GFGIHP+VLDAALHA+G+ E A T+LP Sbjct 1087 GPAFRGLRAVWRRGAEVFAEVEAPQDAGVAVGGFGIHPVVLDAALHALGVADEGAETVLP 1146 Query 1135 FSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAV 1194 FSWQGV LHAAGASRVR R+APAG VSVELAD +GLPVLSV+ LV R VS+ LSAA Sbjct 1147 FSWQGVCLHAAGASRVRVRLAPAGKDAVSVELADSSGLPVLSVRELVTRPVSAAQLSAAA 1206 Query 1195 AAADAAGRGLLEVAWLPVELAHNDISADLVVWELESFQDG-VGPVYSATHRVLVALQSWL 1253 AA G LLE W PV L N VW + DG V V++ATH L LQS Sbjct 1207 AARTGGGE-LLEAVWSPVALPDNPDGPAPEVWRPPANGDGVVASVHAATHAALGLLQS-- 1263 Query 1254 AQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDV 1310 E + LVVLT+G+V G+D T+LAGAAVWGLVRSAQAE+PGRV+LVDSDGS+D V Sbjct 1264 RDEGSAPLVVLTRGAVALPGEDVTDLAGAAVWGLVRSAQAENPGRVVLVDSDGSLDPRAV 1323 Query 1311 IGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKE 1370 +GCGE QL++R G A+ ARLA ++ P+L+LP+ S WRL AG AG LEDL + S P E Sbjct 1324 VGCGEPQLVVRGGVAHRARLAPVKVHPVLRLPEPPSVWRLAAGDAGTLEDLAVQSGPPAE 1383 Query 1371 LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAVGDPVMGL 1430 L GQVR+ V A GVNFRDVLVALG+YPGAA+LGAEGAG+V EVGPGVT LAVGD V+G+ Sbjct 1384 LLAGQVRVAVAAAGVNFRDVLVALGMYPGAAQLGAEGAGLVAEVGPGVTDLAVGDAVLGI 1443 Query 1431 LGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAG 1490 LG+ GSEAVVD RLV ++P W L +AAGVPVVFLTA Y L VLA ++ GE VLVHAAAG Sbjct 1444 LGLTGSEAVVDRRLVTRVPPDWSLAEAAGVPVVFLTALYGLSVLAGLRAGERVLVHAAAG 1503 Query 1491 GVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGV 1550 GVGMAAVQLAR WG EVFATASRGKW+TL MG D+ H+ADSRTL FEE F T G GV Sbjct 1504 GVGMAAVQLARHWGAEVFATASRGKWETLRAMGFDDAHIADSRTLEFEEKFSAATGGAGV 1563 Query 1551 DVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRSL 1589 DVVLNSLAGEFTDASLRLL GGRFIEMGKT+ P +L Sbjct 1564 DVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDLRDPDTL 1602 >gi|240171787|ref|ZP_04750446.1| putative polyketide synthase [Mycobacterium kansasii ATCC 12478] Length=2118 Score = 1857 bits (4810), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1025/1640 (63%), Positives = 1206/1640 (74%), Gaps = 68/1640 (4%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L R RL D E + +EPVAVVG+GCR+PGGVDS E LWE+VA+GRD VS+F Sbjct 18 YLKKVAVELDEARARLRDYEQRATEPVAVVGIGCRFPGGVDSAEKLWEVVAEGRDLVSEF 77 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWDV+GLFDPDPDA GK YTR G FL+ A FDAGFFGI P E LAMDPQQRL+LE Sbjct 78 PTDRGWDVEGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGIAPGEVLAMDPQQRLMLE 137 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGSATGVF G+ YG + +G L+GYGLTG+ +SVASGRV+YV Sbjct 138 VSWEALEHAGIDPLSLRGSATGVFTGIFAPSYGSKETGGLQGYGLTGTAVSVASGRVSYV 197 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVA+H A+ SLRSGECDLALAGGVTVM P+ FV FSRQR LA Sbjct 198 LGLEGPAVSVDTACSSSLVAIHWAMASLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLA 257 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGV+V+ERL DA RLGH VLA+VRGSA+NQDGASNGLTAP Sbjct 258 ADGRCKAFAAAADGTGWGEGAGVVVLERLSDALRLGHSVLAVVRGSAINQDGASNGLTAP 317 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRVE--PLWL 367 NG +QQRVIRAAL SA L A +VDVVE HGT T LGDPIEA ALLATYGQ R E PLW+ Sbjct 318 NGLAQQRVIRAALGSAGLTAADVDVVEAHGTATTLGDPIEANALLATYGQGRPEERPLWV 377 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHG+MP TLHVD P+P VDW GAVS+LT+ R W Sbjct 378 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGLMPATLHVDAPSPRVDWESGAVSVLTEARDW 437 Query 428 SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVAS--PTAASAVPWVLSARSEQA 485 V GRPRRAGVSSFGISGTNAHVILEQA V + + S VPWV+SARS +A Sbjct 438 PVDGRPRRAGVSSFGISGTNAHVILEQASAPAPVATDQTAGGEKRLSVVPWVVSARSAEA 497 Query 486 LAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGES 545 L QA RL A V A+P L+P+DVG +L R++FEHRAVVVGADR AL+ GL ++A G+ Sbjct 498 LTAQASRLAAHVQADPGLEPLDVGCTLAG-RSVFEHRAVVVGADREALITGLTSVADGDP 556 Query 546 GAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLR 605 GAGVAVG+A VGKTV VFPGQG+Q +GMG +LY LP+FA AFD VA+ELD+HLRLPLR Sbjct 557 GAGVAVGQAGPVGKTVVVFPGQGSQRLGMGRELYDRLPVFAEAFDEVADELDQHLRLPLR 616 Query 606 NVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLS 665 V+W GD ALL +TEFAQPALFA+EVAL +L+HWG+ PDF++GHSVGE++AA++AGVL+ Sbjct 617 EVVWGGDAALLDTTEFAQPALFAVEVALFAVLRHWGVQPDFVMGHSVGELSAAYVAGVLT 676 Query 666 LTDAAGLVAARGRLMAELPAGGVMVVVAASE----EEVLPVLVDGANLAAVNAPHSVVVS 721 L DAA LV ARGRLM LPAGG MV VAASE +EV+P+L +G +AA+NAP SV +S Sbjct 677 LADAAMLVVARGRLMQALPAGGAMVAVAASEKEVADEVMPLLGEGVGIAAINAPASVTIS 736 Query 722 GCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSN 781 G EAAVS IAD FA +GRRVHRLAVSHAFHS LMEPML EF RI A + P+I LVSN Sbjct 737 GAEAAVSAIADRFAEQGRRVHRLAVSHAFHSPLMEPMLDEFARIVARLEPRTPQIGLVSN 796 Query 782 VTGQMAGA--GYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSL 839 VTG++A A +G YWV+H RRPVRFA+ + + +GAT F+EVGPG GLT+ +EQSL Sbjct 797 VTGELASATGDFGSAPYWVDHVRRPVRFADSARHVQQLGATHFIEVGPGSGLTSSIEQSL 856 Query 840 PLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQR 898 EA V+M+ ++ PE+++ LGA LFT G +DWPAVF GS GRR++LPTYAFQR+R Sbjct 857 APAEAFVVSMLGKDRPELAAALGAAGQLFTTGVPVDWPAVFAGSGGRRVDLPTYAFQRRR 916 Query 899 YWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGV 958 +W P G AD G+GL H LLGAVVE+PDSD VVLTGRLS+ +Q WLADHV+ GV Sbjct 917 FWETPGGDGPADAVGLGLGPTEHALLGAVVERPDSDGVVLTGRLSLADQPWLADHVVGGV 976 Query 959 VLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG-EMGQRPVSI 1017 VL GA FVEL +RA D+V C V++EL + PLV+ GV++QVVVG + G R VS+ Sbjct 977 VLFPGAGFVELVIRAGDEVGCAVIDELILAAPLVMHPGAGVKVQVVVGAADDAGTRAVSV 1036 Query 1018 YSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRA 1077 YSR D W+LHA G LG +ADLSVWPP GA VD+ Y+R A GY YG+A Sbjct 1037 YSRGDHCDGEWLLHAMGTLGESPAQASADLSVWPPEGAEIVDISDGYERLAARGYAYGKA 1096 Query 1078 FQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAATMLPFSW 1137 FQGL A+WRRESELFA+V P V + G G+HP VLDA LHA+G+ E TMLPF W Sbjct 1097 FQGLVAVWRRESELFAEVVAPAQHGVAVEGMGMHPAVLDAVLHALGLAIETTETMLPFCW 1156 Query 1138 QGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAA 1197 +GVSLHA GA RVRAR+A AG +SVE+AD GLPVL+V ALV R+ +++ L AAV Sbjct 1157 RGVSLHAGGAGRVRARLASAGADAISVEIADAEGLPVLTVGALVTRATTAEQLRAAV--- 1213 Query 1198 DAAGR----GLLEVAWLPVELAHNDI------------------SAD------------- 1222 +AAGR G LEV W P+ L HN I +AD Sbjct 1214 NAAGRGPDQGPLEVVWSPIPLNHNSIEDSDEPAVLSALSWEDYCAADAGTPAGANGNGAG 1273 Query 1223 -----LVVWELESF-QDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDA 1273 +VVWE S D VG Y+ATH L LQSWL +RAG LVVLT+G+V G+D Sbjct 1274 AGDAAVVVWECGSVGADAVGSTYAATHAGLQVLQSWLGTDRAGTLVVLTRGAVGLPGEDV 1333 Query 1274 TNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQL 1333 ++LA AAVWGLVRSAQAE PGR++LVD+D +D + GE QL++R G + ARLA Sbjct 1334 SDLAAAAVWGLVRSAQAEQPGRIVLVDADAPVDAVALAAVGEPQLVVRGGVVHNARLAPA 1393 Query 1334 RPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAKELAPGQ---VRIEVRALGVNFRDV 1390 P L WRL AGG G LEDL + CP + LAP Q VR+ V A+GVNFRDV Sbjct 1394 PPLLALP---AEEAWRLAAGGGGTLEDLVIEPCP-EALAPLQAGQVRVAVAAVGVNFRDV 1449 Query 1391 LVALGIYPGAA-ELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLP 1449 + ALG+YPG A LGAEGAGVV E GP VTG+AVGD VMG LG AG AVVD +LVV+ P Sbjct 1450 VAALGMYPGQAPPLGAEGAGVVIETGPEVTGVAVGDAVMGFLGGAGPLAVVDQQLVVRAP 1509 Query 1450 NRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFA 1509 + W +AA VPVVFLTA + L LA+++ GESVL+HA GGVGMAAVQLAR WG+EVF Sbjct 1510 HGWSFAEAAAVPVVFLTALFGLSDLAEIKGGESVLIHAGTGGVGMAAVQLARHWGVEVFV 1569 Query 1510 TASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLL 1569 TASRGKWDTL MG D+ H+ DSRT FEE F TEGRGVDVVL+SLAGEF DASLRLL Sbjct 1570 TASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLL 1629 Query 1570 PRGGRFIEMGKTEFGTPRSL 1589 RGGRF+EMGKT+ P+ + Sbjct 1630 VRGGRFLEMGKTDIRDPQKI 1649 >gi|15826966|ref|NP_301229.1| polyketide synthase [Mycobacterium leprae TN] gi|221229444|ref|YP_002502860.1| putative polyketide synthase [Mycobacterium leprae Br4923] gi|13092513|emb|CAC29643.1| putative polyketide synthase [Mycobacterium leprae] gi|219932551|emb|CAR70228.1| putative polyketide synthase [Mycobacterium leprae Br4923] Length=2103 Score = 1855 bits (4806), Expect = 0.0, Method: Compositional matrix adjust. Identities = 989/1618 (62%), Positives = 1193/1618 (74%), Gaps = 48/1618 (2%) Query 8 VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVS 67 + YLK++ +L TR RL + E + +EPVAVVG+GCR+PGGVDSP+ LW++V++ RD VS Sbjct 16 ISYLKKVVVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDSPDRLWDVVSECRDVVS 75 Query 68 DFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLL 127 +FP DRGWDVDGLFDPDPDA GK YTR G FL+ A FDAGFFGI PSE LAMDPQQRL+ Sbjct 76 EFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLM 135 Query 128 LEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVA 187 LEVSWEALE GIDP LRGSATGVF G+ YG + +G L+GYGLTG+ +SVASGRV+ Sbjct 136 LEVSWEALEYAGIDPLSLRGSATGVFTGIFAPSYGSRDTGGLQGYGLTGTAVSVASGRVS 195 Query 188 YVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRA 247 YVLGLEGPAVSVDTACSSSLVA+H A+ SLRSGECDLALAGGVTVM P+ FV FSRQR Sbjct 196 YVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRG 255 Query 248 LARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLT 307 LA DGRCK +A AADGT W EGAGV+V+ERL DA+RLGH VLA+VRGSAVNQDGASNGLT Sbjct 256 LAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLT 315 Query 308 APNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRV--EPL 365 APNG +QQRVI+AAL +A L + +VDVVE HGT T LGDPIEAQALLATYGQ R +PL Sbjct 316 APNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQALLATYGQGRPADQPL 375 Query 366 WLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPR 425 W+GSIKSN+GHT AAAGVAGVIKMVQAMRH VMP TLHVD P+P VDW+ GAVS+LT+ R Sbjct 376 WVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEAR 435 Query 426 AWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQA 485 WSV GRPRRAGVSSFGISGTNAHVILE+AP A S VPWV+S RS A Sbjct 436 DWSVEGRPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTADQQRLSVVPWVVSGRSTAA 495 Query 486 LAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGES 545 L QA RL +V A+P++DP+DVG +L R++FEHRAVVVG R L+AGLA LA GES Sbjct 496 LMAQASRLAFYVQADPEVDPVDVGCAL-AARSVFEHRAVVVGESREQLIAGLAGLAVGES 554 Query 546 GAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLR 605 GAGVA+G+A +GKTV VFPGQGAQ +GMG +L ++LP+FA FDAV ELDRH+RLPLR Sbjct 555 GAGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLR 614 Query 606 NVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLS 665 +V+W D LL STEFAQPALFA+EVAL +LQHWG+ PDF++GHS+GE+AAA++AGVL+ Sbjct 615 DVVWGADAGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLA 674 Query 666 LTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEA 725 DAA LV ARGRLM +PAGG M VAASE+EV+ +L +G +AA+NAP SVV+SG +A Sbjct 675 PADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEGVGIAAINAPESVVISGPQA 734 Query 726 AVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQ 785 AVS IAD FA +GRRVH+LAVSHAFHS LMEPML EF R+AA + V KP+I LVSNVTG+ Sbjct 735 AVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKPQIGLVSNVTGE 794 Query 786 MAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEAL 845 +AG +G QYW EH R VRF + + L +GAT F+E GP GL +EQSL EA+ Sbjct 795 LAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAV 854 Query 846 SVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRYWLPPT 904 V+MM ++ PE++SVLGA LF G ++WPAVF GS RR+ LPTYAFQR+R+W P Sbjct 855 VVSMMGKDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPG 914 Query 905 SAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGA 964 + G+A +SG+GL + H LLGAVVE+PDS VVLTGRLS+ Q WLADHVI GVVL GA Sbjct 915 TDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIGGVVLFPGA 974 Query 965 AFVELALRAADQVDCGVVEELTVVTPLVL-PTVGGVQLQVVVGVGEMGQRPVSIYSRNAE 1023 FVEL +RA D+V C VEEL + PLVL P G VV E +R VS+YSR + Sbjct 975 GFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAVSVYSRGDQ 1034 Query 1024 SDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTA 1083 S GW+L+A G+L A DLS+WPP GA VD+ AY + AE GY YG AFQGL A Sbjct 1035 SHGGWLLNAEGLLEVDAAEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQGLVA 1094 Query 1084 MWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE--QAAT--MLPFSWQG 1139 +WRR SELFA+V P V + G G+HP +LDA LHA+G+ E QA T LPF W+G Sbjct 1095 IWRRGSELFAEVVAP--TGVVVDGMGMHPALLDAVLHALGLAIENTQATTEMRLPFCWRG 1152 Query 1140 VSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADA 1199 VSLHA GA RVRAR AG ++V++AD AGLPVL+V++LV R+++++ L AV AA Sbjct 1153 VSLHAGGAGRVRARFTSAGADAIAVDIADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGG 1212 Query 1200 A-GRGLLEVAWLPVELAHN-------------DISA------DLVVWELESFQ------- 1232 A +G +++ W P+ L+ + D A +VVWE S Sbjct 1213 ALEQGPMDLVWSPIPLSSDGHGGGLPSVVSWADYCAGRGNDTGVVVWEFGSASAGAQAPV 1272 Query 1233 DGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGS---VGQDATNLAGAAVWGLVRSAQ 1289 D V VYSATH L LQ W Q+RAG LVVLT+G+ VG+ ++LA AAVWG+VRSAQ Sbjct 1273 DSVAAVYSATHAALQVLQFWFGQDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQ 1332 Query 1290 AEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQP-ILQLPDTNSGW 1348 +EH G+++L+D+D ++DV + GE QL++R T +AARL+ P P +L LP S W Sbjct 1333 SEHSGKIVLIDTDSAVDVAVLADLGESQLLVRCNTVHAARLS---PAPQLLALPVGESMW 1389 Query 1349 RLVAGGAGALEDLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAA-ELGA 1405 RL A G G LEDL + CP + L G +R+ V A+GVNFRDV+ ALG+YPG A LGA Sbjct 1390 RLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMYPGQAPPLGA 1449 Query 1406 EGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFL 1465 EGAGVV E+GP VTG+AVGD VMG LG AG AVV +L+ ++P W L +AA VPVVFL Sbjct 1450 EGAGVVIEIGPEVTGVAVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFL 1509 Query 1466 TAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCD 1525 TA + L LA ++ GESVL+HA GGVGMAAVQ AR WG+E+F TASRGKWDTL MG D Sbjct 1510 TALFGLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFD 1569 Query 1526 NTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 + H+ DSRTL FEE F T+GRGVDVVL+SLAG+F DASLRLL RGGRF+EMGKT+ Sbjct 1570 DDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMGKTDI 1627 >gi|289575652|ref|ZP_06455879.1| polyketide synthase pks1 [Mycobacterium tuberculosis K85] gi|339632954|ref|YP_004724596.1| polyketide synthase [Mycobacterium africanum GM041182] gi|289540083|gb|EFD44661.1| polyketide synthase pks1 [Mycobacterium tuberculosis K85] gi|339332310|emb|CCC28022.1| putative polyketide synthase [Mycobacterium africanum GM041182] Length=2112 Score = 1845 bits (4780), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1010/1619 (63%), Positives = 1199/1619 (75%), Gaps = 50/1619 (3%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L TR RL + E + +EPVAVVG+GCR+PGGVD P+ LW++V+ GRD VS+F Sbjct 23 YLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEF 82 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWDV+GL+DPDPDA GK YTR G FL+ A FDAGFFGI PSE LAMDPQQRL+LE Sbjct 83 PTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLE 142 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGSATGV+ G+ A YG + +G L+GYGLTG+++SVASGRV+YV Sbjct 143 VSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYV 202 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGL+GPAVSVDTACSSSLVA+H A+ SLRSGECDLALAGGVTVM P+ FV FSRQR LA Sbjct 203 LGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLA 262 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGV+V+ERL DARRLGH VLA+VRGSAVNQDGASNGLTAP Sbjct 263 ADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAP 322 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR--VEPLWL 367 NG +QQRVI+AALA+A L A +VDVVE HGT T LGDPIEAQALL+TYGQ R +PLW+ Sbjct 323 NGLAQQRVIQAALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGRPAEQPLWV 382 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHGVMP TLHVD P+P VDW+ GAVS+LT+ R W Sbjct 383 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREW 442 Query 428 SVHGRPRRAGVSSFGISGTNAHVIL-----EQAPVVESVVPEVASPTAASAVPWVLSARS 482 SV GRPRRA VSSFGISGTNAH+IL E S VPWV+SARS Sbjct 443 SVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGPRPSMVPWVISARS 502 Query 483 EQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAA 542 +AL QA RL+A V ANP LDPIDVG SL +R++FEHRAVVVGA R L+AGLA LAA Sbjct 503 AEALTAQAGRLMAHVQANPGLDPIDVGCSLA-SRSVFEHRAVVVGASREQLIAGLAGLAA 561 Query 543 GESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRL 602 GE GAGVAVG+ SVGKTV VFPGQGAQ +GMG +LY ELP+FA AFDAVA+ELDRHLRL Sbjct 562 GEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRL 621 Query 603 PLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAG 662 PLR+V+W D LL STEFAQPALFA+EVA +L+ WG+ PDF++GHSVGE+AAAH AG Sbjct 622 PLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAG 681 Query 663 VLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSG 722 VL+L DAA LV ARGRLM LPAGG MV VAASE+EV P+L +G +AA+NAP SVV+SG Sbjct 682 VLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISG 741 Query 723 CEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNV 782 +AA + IAD FA +GRRVH+LAVSHAFHS LMEPML EF R+AA + +P++ LVSNV Sbjct 742 AQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNV 801 Query 783 TGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLG 842 TG++AG +G QYWV+H RRPVRFA+ + L +GAT F+E GPG GLT +EQSL Sbjct 802 TGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPA 861 Query 843 EALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRYWL 901 EA+ V+M+ ++ PE++S LGA +FT G + W AVF GS GRR++LPTYAFQR+R+W Sbjct 862 EAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWE 921 Query 902 PPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLL 961 P + G AD +G+GL A H LLGAVVE+PDSD VVLTGRLS+ +Q WLADHV+ GVVL Sbjct 922 TPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLF 981 Query 962 AGAAFVELALRAADQVDCGVVEELTVVTPLVL-PTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 GA FVEL +RA D+V C ++EEL + PLV+ P VG VV E G R VS+YSR Sbjct 982 PGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSR 1041 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 +S GW+L+A G+LG A DLSVWPP GA VD+ Y + AE GY YG AFQG Sbjct 1042 GDQS-QGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQG 1100 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAA----TMLPFS 1136 L A+WRR SELFA+V P + V + G+HP VLDA LHA+G+ E+ T LPF Sbjct 1101 LVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFC 1160 Query 1137 WQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAA 1196 W+GVSLHA GA RVRAR A AG +SV++ D GLPVL+V++LV R ++++ L AAV A Sbjct 1161 WRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTA 1220 Query 1197 A-DAAGRGLLEVAWLPVEL--------------------AHNDISADLVVWELES----F 1231 A A+ +G LEV W P+ + A +D A +VVWELES Sbjct 1221 AGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQA 1280 Query 1232 QDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSA 1288 VG VY+ATH L LQSWL +RA LVVLT G V G+D ++LA AAVWG+ RSA Sbjct 1281 SSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSA 1340 Query 1289 QAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGW 1348 QAE+PGR++L+D+D ++D + G GE QL++R GT +A RL+ L S W Sbjct 1341 QAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPA--AESAW 1398 Query 1349 RLVAGGAGALEDLTLASCPAKELAPGQ---VRIEVRALGVNFRDVLVALGIYPGAA-ELG 1404 RL AGG G LEDL + CP + AP Q VR+ V A+GVNFRDV+ ALG+YPG A LG Sbjct 1399 RLAAGGGGTLEDLVIQPCPEVQ-APLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLG 1457 Query 1405 AEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVF 1464 AEGAGVV E GP VT LAVGD VMG LG AG AVVD +LV ++P W AA VPVVF Sbjct 1458 AEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVF 1517 Query 1465 LTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGC 1524 LTA+Y L LA+++ GESVL+HA GGVGMAAVQLAR WG+EVF TASRGKWDTL MG Sbjct 1518 LTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGF 1577 Query 1525 DNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 D+ H+ DSRT FEE F TEGRGVDVVL+SLAGEF DASLRLL RGGRF+EMGKT+ Sbjct 1578 DDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1636 >gi|31794123|ref|NP_856616.1| polyketide synthase PKS1 [Mycobacterium bovis AF2122/97] gi|121638828|ref|YP_979052.1| putative polyketide synthase pks1 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224991320|ref|YP_002646009.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|81421699|sp|Q7TXK8.1|MSL7_MYCBO RecName: Full=Phenolphthiocerol synthesis polyketide synthase type I Pks15/1; AltName: Full=Beta-ketoacyl-acyl-carrier-protein synthase I gi|31619718|emb|CAD96658.1| PROBABLE POLYKETIDE SYNTHASE PKS1 [Mycobacterium bovis AF2122/97] gi|121494476|emb|CAL72957.1| Probable polyketide synthase pks1 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224774435|dbj|BAH27241.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341602867|emb|CCC65545.1| probable polyketide synthase pks1 [Mycobacterium bovis BCG str. Moreau RDJ] Length=2112 Score = 1843 bits (4775), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1010/1619 (63%), Positives = 1199/1619 (75%), Gaps = 50/1619 (3%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L TR RL + E + +EPVAVVG+GCR+PGGVD P+ LW++V+ GRD VS+F Sbjct 23 YLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEF 82 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWDV+GL+DPDPDA GK YTR G FL+ A FDAGFFGI PSE LAMDPQQRL+LE Sbjct 83 PTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLE 142 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGSATGV+ G+ A YG + +G L+GYGLTG+++SVASGRV+YV Sbjct 143 VSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYV 202 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGL+GPAVSVDTACSSSLVA+H A+ SLRSGECDLALAGGVTVM P+ FV FSRQR LA Sbjct 203 LGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLA 262 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGV+V+ERL DARRLGH VLA+VRGSAVNQDGASNGLTAP Sbjct 263 ADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAP 322 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR--VEPLWL 367 NG +QQRVI+AALA+A L A +VDVVE HGT T LGDPIEAQALL+TYGQ R +PLW+ Sbjct 323 NGLAQQRVIQAALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGRPAEQPLWV 382 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHGVMP TLHVD P+P VDW+ GAVS+LT+ R W Sbjct 383 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREW 442 Query 428 SVHGRPRRAGVSSFGISGTNAHVIL-----EQAPVVESVVPEVASPTAASAVPWVLSARS 482 SV GRPRRA VSSFGISGTNAH+IL E S VPWV+SARS Sbjct 443 SVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGPRPSMVPWVISARS 502 Query 483 EQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAA 542 +AL QA RL+A V ANP LDPIDVG SL +R++FEHRAVVVGA R L+AGLA LAA Sbjct 503 AEALTAQAGRLMAHVQANPGLDPIDVGCSLA-SRSVFEHRAVVVGASREQLIAGLAGLAA 561 Query 543 GESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRL 602 GE GAGVAVG+ SVGKTV VFPGQGAQ +GMG +LY ELP+FA AFDAVA+ELDRHLRL Sbjct 562 GEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHLRL 621 Query 603 PLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAG 662 PLR+V+W D LL STEFAQPALFA+EVA +L+ WG+ PDF++GHSVGE+AAAH AG Sbjct 622 PLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAG 681 Query 663 VLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSG 722 VL+L DAA LV ARGRLM LPAGG MV VAASE+EV P+L +G +AA+NAP SVV+SG Sbjct 682 VLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISG 741 Query 723 CEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNV 782 +AA + IAD FA +GRRVH+LAVSHAFHS LMEPML EF R+AA + +P++ LVSNV Sbjct 742 AQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNV 801 Query 783 TGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLG 842 TG++AG +G QYWV+H RRPVRFA+ + L +GAT F+E GPG GLT +EQSL Sbjct 802 TGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPA 861 Query 843 EALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRYWL 901 EA+ V+M+ ++ PE++S LGA +FT G + W AVF GS GRR++LPTYAFQR+R+W Sbjct 862 EAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWE 921 Query 902 PPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLL 961 P + G AD +G+GL A H LLGAVVE+PDSD VVLTGRLS+ +Q WLADHV+ GVVL Sbjct 922 TPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLF 981 Query 962 AGAAFVELALRAADQVDCGVVEELTVVTPLVL-PTVGGVQLQVVVGVGEMGQRPVSIYSR 1020 GA FVEL +RA D+V C ++EEL + PLV+ P VG VV E G R VS+YSR Sbjct 982 PGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSR 1041 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 +S GW+L+A G+LG A DLSVWPP GA VD+ Y + AE GY YG AFQG Sbjct 1042 GDQS-QGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQG 1100 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAA----TMLPFS 1136 L A+WRR SELFA+V P + V + G+HP VLDA LHA+G+ E+ T LPF Sbjct 1101 LVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFC 1160 Query 1137 WQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAA 1196 W+GVSLHA GA RVRAR A AG +SV++ D GLPVL+V++LV R ++++ L AAV A Sbjct 1161 WRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTA 1220 Query 1197 A-DAAGRGLLEVAWLPVEL--------------------AHNDISADLVVWELES----F 1231 A A+ +G LEV W P+ + A +D A +VVWELES Sbjct 1221 AGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQA 1280 Query 1232 QDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSA 1288 VG VY+ATH L LQSWL +RA LVVLT G V G+D ++LA AAVWG+ RSA Sbjct 1281 SSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSA 1340 Query 1289 QAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGW 1348 QAE+PGR++L+D+D ++D + G GE QL++R GT +A RL+ L S W Sbjct 1341 QAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPA--AESAW 1398 Query 1349 RLVAGGAGALEDLTLASCPAKELAPGQ---VRIEVRALGVNFRDVLVALGIYPGAA-ELG 1404 RL AGG G LEDL + CP + AP Q VR+ V A+GVNFRDV+ ALG+YPG A LG Sbjct 1399 RLAAGGGGTLEDLVIQPCPEVQ-APLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLG 1457 Query 1405 AEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVF 1464 AEGAGVV E GP VT LAVGD VMG LG AG AVVD +LV ++P W AA VPVVF Sbjct 1458 AEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVF 1517 Query 1465 LTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGC 1524 LTA+Y L LA+++ GESVL+HA GGVGMAAVQLAR WG+EVF TASRGKWDTL MG Sbjct 1518 LTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGF 1577 Query 1525 DNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 D+ H+ DSRT FEE F TEGRGVDVVL+SLAGEF DASLRLL RGGRF+EMGKT+ Sbjct 1578 DDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1636 >gi|294993968|ref|ZP_06799659.1| putative polyketide synthase [Mycobacterium tuberculosis 210] gi|326904561|gb|EGE51494.1| polyketide synthase pks1 [Mycobacterium tuberculosis W-148] Length=2107 Score = 1841 bits (4769), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1013/1621 (63%), Positives = 1205/1621 (75%), Gaps = 52/1621 (3%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L TR RL + E + +EPVAVVG+GCR+PGGVD P+ LW++V+ GRD VS+F Sbjct 16 YLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEF 75 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWDV+GL+DPDPDA GK YTR G FL+ A FDAGFFGI PSE LAMDPQQRL+LE Sbjct 76 PTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLE 135 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGSATGV+ G+ A YG + +G L+GYGLTG+++SVASGRV+YV Sbjct 136 VSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYV 195 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGL+GPAVSVDTACSSSLVA+H A+ SLRSGECDLALAGGVTVM P+ FV FSRQR LA Sbjct 196 LGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLA 255 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGV+V+ERL DARRLGH VLA+VRGSAVNQDGASNGLTAP Sbjct 256 ADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAP 315 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQ--DRVEPLWL 367 NG +QQRVI+AALA+A L A +VDVVE HGT T LGDPIEAQALL+TYGQ +PLW+ Sbjct 316 NGLAQQRVIQAALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWV 375 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHGVMP TLHVD P+P VDW+ GAVS+LT+ R W Sbjct 376 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREW 435 Query 428 SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAA-------SAVPWVLSA 480 SV GRPRRA VSSFGISGTNAH+ILE+APV V + + S VPWV+SA Sbjct 436 SVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGPRPSMVPWVISA 495 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RS +AL QA RL+A V ANP LDPIDVG SL +R++FEHRAVVVGA R L+AGLA L Sbjct 496 RSAEALTAQAGRLMAHVQANPGLDPIDVGCSLA-SRSVFEHRAVVVGASREQLIAGLAGL 554 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGE GAGVAVG+ SVGKTV VFPGQGAQ +GMG +LY ELP+FA AFDAVA+ELDRHL Sbjct 555 AAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHL 614 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLR+V+W D LL STEFAQPALFA+EVA +L+ WG+ PDF++GHSVGE+AAAH Sbjct 615 RLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHA 674 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVL+L DAA LV ARGRLM LPAGG MV VAASE+EV P+L +G +AA+NAP SVV+ Sbjct 675 AGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVI 734 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SG +AA + IAD FA +GRRVH+LAVSHAFHS LMEPML EF R+AA + +P++ LVS Sbjct 735 SGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVS 794 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTG++AG +G QYWV+H RRPVRFA+ + L +GAT F+E GPG GLT +EQSL Sbjct 795 NVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLA 854 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRY 899 EA+ V+M+ ++ PE++S LGA +FT G + W AVF GS GRR++LPTYAFQR+R+ Sbjct 855 PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRF 914 Query 900 WLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVV 959 W P + G AD +G+GL A H LLGAVVE+PDSD VVLTGRLS+ +Q WLADHV+ GVV Sbjct 915 WETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVV 974 Query 960 LLAGAAFVELALRAADQVDCGVVEELTVVTPLVL-PTVGGVQLQVVVGVGEMGQRPVSIY 1018 L GA FVEL +RA D+V C ++EEL + PLV+ P VG VV E G R VS+Y Sbjct 975 LFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVY 1034 Query 1019 SRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAF 1078 SR +S GW+L+A G+LG A DLSVWPP GA VD+ Y + AE GY YG AF Sbjct 1035 SRGDQS-QGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAF 1093 Query 1079 QGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAA----TMLP 1134 QGL A+WRR SELFA+V P + V + G+HP VLDA LHA+G+ E+ T LP Sbjct 1094 QGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLP 1153 Query 1135 FSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAV 1194 F W+GVSLHA GA RVRAR A AG +SV++ D GLPVL+V++LV R ++++ L AAV Sbjct 1154 FCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAV 1213 Query 1195 AAA-DAAGRGLLEVAWLPVEL--------------------AHNDISADLVVWELES--- 1230 AA A+ +G LEV W P+ + A +D A +VVWELES Sbjct 1214 TAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGG 1273 Query 1231 -FQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVR 1286 VG VY+ATH L LQSWL +RA LVVLT G V G+D ++LA AAVWG+ R Sbjct 1274 QASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMAR 1333 Query 1287 SAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNS 1346 SAQAE+PGR++L+D+D ++D + G GE QL++R GT +A RL+ L S Sbjct 1334 SAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPA--AES 1391 Query 1347 GWRLVAGGAGALEDLTLASCPAKELAPGQ---VRIEVRALGVNFRDVLVALGIYPGAA-E 1402 WRL AGG G LEDL + CP + AP Q VR+ V A+GVNFRDV+ ALG+YPG A Sbjct 1392 AWRLAAGGGGTLEDLVIQPCPEVQ-APLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPP 1450 Query 1403 LGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPV 1462 LGAEGAGVV E GP VT LAVGD VMG LG AG AVVD +LV ++P W AA VPV Sbjct 1451 LGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPV 1510 Query 1463 VFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTM 1522 VFLTA+Y L LA+++ GESVL+HA GGVGMAAVQLAR WG+EVF TASRGKWDTL M Sbjct 1511 VFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAM 1570 Query 1523 GCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTE 1582 G D+ H+ DSRT FEE F TEGRGVDVVL+SLAGEF DASLRLL RGGRF+EMGKT+ Sbjct 1571 GFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTD 1630 Query 1583 F 1583 Sbjct 1631 I 1631 >gi|289746746|ref|ZP_06506124.1| polyketide synthase PKS1 [Mycobacterium tuberculosis 02_1987] gi|298526415|ref|ZP_07013824.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|289687274|gb|EFD54762.1| polyketide synthase PKS1 [Mycobacterium tuberculosis 02_1987] gi|298496209|gb|EFI31503.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] Length=2114 Score = 1840 bits (4767), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1013/1621 (63%), Positives = 1205/1621 (75%), Gaps = 52/1621 (3%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L TR RL + E + +EPVAVVG+GCR+PGGVD P+ LW++V+ GRD VS+F Sbjct 23 YLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDVVSAGRDVVSEF 82 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWDV+GL+DPDPDA GK YTR G FL+ A FDAGFFGI PSE LAMDPQQRL+LE Sbjct 83 PTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLE 142 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGSATGV+ G+ A YG + +G L+GYGLTG+++SVASGRV+YV Sbjct 143 VSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYV 202 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGL+GPAVSVDTACSSSLVA+H A+ SLRSGECDLALAGGVTVM P+ FV FSRQR LA Sbjct 203 LGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLA 262 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGV+V+ERL DARRLGH VLA+VRGSAVNQDGASNGLTAP Sbjct 263 ADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAP 322 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQ--DRVEPLWL 367 NG +QQRVI+AALA+A L A +VDVVE HGT T LGDPIEAQALL+TYGQ +PLW+ Sbjct 323 NGLAQQRVIQAALANAGLSAADVDVVEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWV 382 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHGVMP TLHVD P+P VDW+ GAVS+LT+ R W Sbjct 383 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREW 442 Query 428 SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAA-------SAVPWVLSA 480 SV GRPRRA VSSFGISGTNAH+ILE+APV V + + S VPWV+SA Sbjct 443 SVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGPRPSMVPWVISA 502 Query 481 RSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAAL 540 RS +AL QA RL+A V ANP LDPIDVG SL +R++FEHRAVVVGA R L+AGLA L Sbjct 503 RSAEALTAQAGRLMAHVQANPGLDPIDVGCSLA-SRSVFEHRAVVVGASREQLIAGLAGL 561 Query 541 AAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHL 600 AAGE GAGVAVG+ SVGKTV VFPGQGAQ +GMG +LY ELP+FA AFDAVA+ELDRHL Sbjct 562 AAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDRHL 621 Query 601 RLPLRNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHL 660 RLPLR+V+W D LL STEFAQPALFA+EVA +L+ WG+ PDF++GHSVGE+AAAH Sbjct 622 RLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHA 681 Query 661 AGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVV 720 AGVL+L DAA LV ARGRLM LPAGG MV VAASE+EV P+L +G +AA+NAP SVV+ Sbjct 682 AGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVI 741 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 SG +AA + IAD FA +GRRVH+LAVSHAFHS LMEPML EF R+AA + +P++ LVS Sbjct 742 SGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVS 801 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP 840 NVTG++AG +G QYWV+H RRPVRFA+ + L +GAT F+E GPG GLT +EQSL Sbjct 802 NVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLA 861 Query 841 LGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRY 899 EA+ V+M+ ++ PE++S LGA +FT G + W AVF GS GRR++LPTYAFQR+R+ Sbjct 862 PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRF 921 Query 900 WLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVV 959 W P + G AD +G+GL A H LLGAVVE+PDSD VVLTGRLS+ +Q WLADHV+ GVV Sbjct 922 WETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVV 981 Query 960 LLAGAAFVELALRAADQVDCGVVEELTVVTPLVL-PTVGGVQLQVVVGVGEMGQRPVSIY 1018 L GA FVEL +RA D+V C ++EEL + PLV+ P VG VV E G R VS+Y Sbjct 982 LFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVY 1041 Query 1019 SRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAF 1078 SR +S GW+L+A G+LG A DLSVWPP GA VD+ Y + AE GY YG AF Sbjct 1042 SRGDQS-QGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAF 1100 Query 1079 QGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAA----TMLP 1134 QGL A+WRR SELFA+V P + V + G+HP VLDA LHA+G+ E+ T LP Sbjct 1101 QGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLP 1160 Query 1135 FSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAV 1194 F W+GVSLHA GA RVRAR A AG +SV++ D GLPVL+V++LV R ++++ L AAV Sbjct 1161 FCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAV 1220 Query 1195 AAA-DAAGRGLLEVAWLPVEL--------------------AHNDISADLVVWELES--- 1230 AA A+ +G LEV W P+ + A +D A +VVWELES Sbjct 1221 TAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGG 1280 Query 1231 -FQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVR 1286 VG VY+ATH L LQSWL +RA LVVLT G V G+D ++LA AAVWG+ R Sbjct 1281 QASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMAR 1340 Query 1287 SAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNS 1346 SAQAE+PGR++L+D+D ++D + G GE QL++R GT +A RL+ L S Sbjct 1341 SAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPA--AES 1398 Query 1347 GWRLVAGGAGALEDLTLASCPAKELAPGQ---VRIEVRALGVNFRDVLVALGIYPGAA-E 1402 WRL AGG G LEDL + CP + AP Q VR+ V A+GVNFRDV+ ALG+YPG A Sbjct 1399 AWRLAAGGGGTLEDLVIQPCPEVQ-APLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPP 1457 Query 1403 LGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPV 1462 LGAEGAGVV E GP VT LAVGD VMG LG AG AVVD +LV ++P W AA VPV Sbjct 1458 LGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPV 1517 Query 1463 VFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTM 1522 VFLTA+Y L LA+++ GESVL+HA GGVGMAAVQLAR WG+EVF TASRGKWDTL M Sbjct 1518 VFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAM 1577 Query 1523 GCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTE 1582 G D+ H+ DSRT FEE F TEGRGVDVVL+SLAGEF DASLRLL RGGRF+EMGKT+ Sbjct 1578 GFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTD 1637 Query 1583 F 1583 Sbjct 1638 I 1638 >gi|183981775|ref|YP_001850066.1| polyketide synthase Pks15/1 [Mycobacterium marinum M] gi|327488289|sp|B2HIL7.1|MSL7_MYCMM RecName: Full=Phenolphthiocerol synthesis polyketide synthase type I Pks15/1; AltName: Full=Beta-ketoacyl-acyl-carrier-protein synthase I gi|183175101|gb|ACC40211.1| polyketide synthase Pks15/1 [Mycobacterium marinum M] Length=2104 Score = 1819 bits (4712), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1008/1620 (63%), Positives = 1218/1620 (76%), Gaps = 53/1620 (3%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L R RL + E + +EPVAVVG+GCR+PGG D PE LW+LV+QGRDAV++F Sbjct 18 YLKKVAVELDEARARLREYEQRATEPVAVVGIGCRFPGGADGPEGLWDLVSQGRDAVTEF 77 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWD +GLFDPDPDA GK YTR G F+E+A +FDAGFFGI PSE LAMDPQQRL+LE Sbjct 78 PNDRGWDTEGLFDPDPDAEGKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLE 137 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGS+TGVF G+ YGG+ G L+GYGLTGS +SVASGRVAYV Sbjct 138 VSWEALEHAGIDPMSLRGSSTGVFTGIFAPSYGGKDVGALQGYGLTGSPVSVASGRVAYV 197 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPA+SVDTACSSSLVA+H A+ SLRSGECD+ALAGGVTVM P+ FV FSRQR LA Sbjct 198 LGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFSRQRGLA 257 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGVLV+ERL DA+R GH VLA+VRGSA+NQDGASNGLTAP Sbjct 258 ADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAVVRGSAINQDGASNGLTAP 317 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRV--EPLWL 367 NG +QQRVI+AALA+ L + +VDVVE HGT T LGDPIEA+ALLATYGQ R +PLW+ Sbjct 318 NGLAQQRVIQAALANCGLTSADVDVVEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWV 377 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHG+MP +LHVD P+ VDW GAVS+L + R W Sbjct 378 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDW 437 Query 428 SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASA---VPWVLSARSEQ 484 GRPRRAGVSSFGISGTNAHVILE+AP E+ VP+ S + VPWV+SARS + Sbjct 438 PDAGRPRRAGVSSFGISGTNAHVILEEAPAPEA-VPDSESNKGEPSLPVVPWVISARSAE 496 Query 485 ALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE 544 AL QA RLLA V A+P +P+D+G+SL R+ FEHRAVVVGADR LL GLA LA G Sbjct 497 ALTAQAGRLLAHVQADPQSNPVDIGFSLAG-RSAFEHRAVVVGADRQQLLTGLATLADGA 555 Query 545 SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPL 604 GAGV G+A SVGKT VFPGQG+Q +GM +L+ +LP+FA AFDAVA+ELDRHLR+PL Sbjct 556 PGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPL 615 Query 605 RNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVL 664 R V+W D ALL STEFAQPALFA+EVAL LQ WG+ PDF++GHSVGE++AA++AGVL Sbjct 616 REVMWGSDAALLDSTEFAQPALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVL 675 Query 665 SLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCE 724 +L DAA LV ARGRLM LPAGG MV VAA+E+EVLP L DG +AA+NAP SVV+SG E Sbjct 676 TLADAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAAINAPKSVVISGAE 735 Query 725 AAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTG 784 AAV+ I+D FA++GRRVHRLAVSHAFHS LMEPML EF RIAA + +P+I LVSNVTG Sbjct 736 AAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIAAQVEAREPQIALVSNVTG 795 Query 785 QMAGA--GYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLG 842 ++A A G+G QYWVEH RR VRFA+ + L+ +G T FVEVGPG GLT +EQSL Sbjct 796 ELASADGGFGSAQYWVEHVRRAVRFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPA 855 Query 843 EALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRYWL 901 EA+ V+M+ ++ PEV+SVL A LF+ G +DWPAVF GS R++LPTYAFQR+R+W Sbjct 856 EAVVVSMLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWE 915 Query 902 PPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLL 961 P + G AD +G+GL A H LLGAVVE+PDS VVLTGRL++ +Q WLADHVI GVVL Sbjct 916 VPGADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVIGGVVLF 975 Query 962 AGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG-EMGQRPVSIYSR 1020 GA FVELA+RA D+V C VVEEL + PLVL GVQ+QV+VG + G R +S+YSR Sbjct 976 PGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGAADDSGNRALSVYSR 1035 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 +S+ W+L+A G+LG +A + ADLSVWPP GA VD+ Y + A+ GY YG FQG Sbjct 1036 GDQSED-WLLNAEGMLGVEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG 1094 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQA----ATMLPFS 1136 L +WRR+SELFA+V P V V G+HP+VLDA LHA+G+ EQ T LPF Sbjct 1095 LVGVWRRDSELFAEVVAPSGVAV--DKMGMHPVVLDAVLHALGLTAEQNPDSDETKLPFC 1152 Query 1137 WQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAA 1196 W+GVSLHA GA RVRAR+ +G ++SVE+AD AGLPVL+V ALV R++S+ L AAVAA Sbjct 1153 WRGVSLHAGGAGRVRARLTMSGPDSISVEIADAAGLPVLTVGALVTRAMSAAQLRAAVAA 1212 Query 1197 ADAA--GRGLLEVAWLPVELAHNDIS----------ADLV--------------VWELE- 1229 A +G L+V W P+ L+ + + AD VWE Sbjct 1213 AGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAAGDAGVVVWEPNP 1272 Query 1230 SFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVR 1286 + +D VG VY+ATH L LQSW +RAG LVVLT G+V G++ ++LAGAAVWG+VR Sbjct 1273 AGEDVVGSVYAATHAALEVLQSWFDGDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVR 1332 Query 1287 SAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNS 1346 SAQAE+PGR++LVD+D +++ +++ GE QL++R+G A+AARLA P + + S Sbjct 1333 SAQAENPGRIVLVDADAAVEAAELVAVGEPQLVVRSGAAHAARLAPAAPLLAVPADE--S 1390 Query 1347 GWRLVAGGAGALEDLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAA-EL 1403 WRL AGG G LEDL + CP + LA GQVR+ VRA+GVNFRDV+ ALG+YPG A L Sbjct 1391 AWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMYPGEAPPL 1450 Query 1404 GAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVV 1463 GAEGAGVV EVGP V+G+AVGD VMG LG AG +VVD +L+ ++P W AA VPVV Sbjct 1451 GAEGAGVVLEVGPQVSGVAVGDSVMGFLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVV 1510 Query 1464 FLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMG 1523 FLTA + L+ LA++QPGESVL+HA GGVGMAAVQLAR WG+E+F TASRGKWDTL MG Sbjct 1511 FLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMG 1570 Query 1524 CDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 D+ H+ DSRTL FEE F T+GRGVDVVL+SLAG+F DASLRLL RGGRF+EMGKT+ Sbjct 1571 FDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMGKTDI 1630 >gi|118617583|ref|YP_905915.1| polyketide synthase Pks15/1 [Mycobacterium ulcerans Agy99] gi|118569693|gb|ABL04444.1| polyketide synthase Pks15/1 [Mycobacterium ulcerans Agy99] Length=2104 Score = 1817 bits (4707), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1007/1620 (63%), Positives = 1217/1620 (76%), Gaps = 53/1620 (3%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 YLK++ +L R RL + E + +EPVAVVG+GCR+PGG D PE LW+LV+QGRDAV++F Sbjct 18 YLKKVAVELDEARARLREYEQRATEPVAVVGIGCRFPGGADGPEGLWDLVSQGRDAVTEF 77 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWD +GLFDPDPDA GK YTR G F+E+A +FDAGFFGI PSE LAMDPQQRL+LE Sbjct 78 PNDRGWDTEGLFDPDPDAEGKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLE 137 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 VSWEALE GIDP LRGS+TGVF G+ YGG+ G L+GYGLTGS +SVASGRVAYV Sbjct 138 VSWEALEHAGIDPMSLRGSSTGVFTGIFAPSYGGKDVGALQGYGLTGSPVSVASGRVAYV 197 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPA+SVDTACSSSLVA+H A+ SLRSGECD+ALAGGVTVM P+ FV FSRQR LA Sbjct 198 LGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFSRQRGLA 257 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT W EGAGVLV+ERL DA+R GH VLA+VRGSA+NQDGASNGLTAP Sbjct 258 ADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAVVRGSAINQDGASNGLTAP 317 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRV--EPLWL 367 NG +QQRVI+AALA+ L + +VDVVE HGT T LGDPIEA+ALLATYGQ R +PLW+ Sbjct 318 NGLTQQRVIQAALANCGLTSADVDVVEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWV 377 Query 368 GSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW 427 GSIKSN+GHT AAAGVAGVIKMVQAMRHG+MP +LHVD P+ VDW GAVS+L + R W Sbjct 378 GSIKSNMGHTQAAAGVAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDW 437 Query 428 SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASA---VPWVLSARSEQ 484 GRPRRAGVSSFGISGTNAHVILE+AP E+ VP+ S + VPWV+SARS + Sbjct 438 PDAGRPRRAGVSSFGISGTNAHVILEEAPAPEA-VPDSESNKGEPSLPVVPWVISARSAE 496 Query 485 ALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE 544 AL QA RLLA V A+P +P+D+G+SL R+ FEHRAVVVGADR LL GLA LA G Sbjct 497 ALTAQAGRLLAHVQADPQSNPVDIGFSLAG-RSAFEHRAVVVGADRQQLLTGLATLADGA 555 Query 545 SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPL 604 GAGV G+A SVGKT VFPGQG+Q +GM +L+ +LP+FA AFDAVA+ELDRHLR+PL Sbjct 556 PGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPL 615 Query 605 RNVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVL 664 V+W D ALL STEFAQ ALFA+EVAL LQ WG+ PDF++GHSVGE++AA++AGVL Sbjct 616 CEVMWGSDVALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVL 675 Query 665 SLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCE 724 +L DAA LV ARGRLM LPAGG MV VAA+E+EVLP L DG +AA+NAP SVV+SG E Sbjct 676 TLVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAAINAPKSVVISGAE 735 Query 725 AAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTG 784 AAV+ I+D FA++GRRVHRLAVSHAFHS LMEPML EF RIAA + +P+I LVSNVTG Sbjct 736 AAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIAAQVEAREPQIALVSNVTG 795 Query 785 QMAGA--GYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLG 842 ++A A G+G QYWVEH RR VRFA+ + L+ +G T FVEVGPG GLT +EQSL Sbjct 796 ELASADGGFGSAQYWVEHVRRAVRFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAPA 855 Query 843 EALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQRQRYWL 901 EA+ V+M+ ++ PEV+SVL A LF+ G +DWPAVF GS R++LPTYAFQR+R+W Sbjct 856 EAVVVSMLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWE 915 Query 902 PPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLL 961 P + G AD +G+GL A H LLGAVVE+PDS VVLTGRL++ +Q WLADHVI GVVL Sbjct 916 VPGADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVIGGVVLF 975 Query 962 AGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG-EMGQRPVSIYSR 1020 GA FVELA+RA D+V C VVEEL + PLVL GVQ+QV+VG + G R +S+YSR Sbjct 976 PGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGTADDSGNRALSVYSR 1035 Query 1021 NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQG 1080 +S+ W+L+A G+LG +A + ADLSVWPP GA VD+ Y + A+ GY YG FQG Sbjct 1036 GDKSED-WLLNAEGMLGVEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG 1094 Query 1081 LTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQA----ATMLPFS 1136 L +WRR+SELFA+V P V V G+HP+VLDA LHA+G+ EQ T LPF Sbjct 1095 LVGVWRRDSELFAEVVAPSGVAV--DKMGMHPVVLDAVLHALGLTAEQNPDSDETKLPFC 1152 Query 1137 WQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAA 1196 W+GVSLHA GA RVRAR+ +G ++SVE+AD AGLPVL+V ALV R++S+ L AAVA Sbjct 1153 WRGVSLHAGGAGRVRARLTMSGPDSISVEIADAAGLPVLTVGALVTRAMSAAQLRAAVAE 1212 Query 1197 ADAA--GRGLLEVAWLPVELAHNDIS----------ADLV--------------VWELE- 1229 A +G L+V W P+ L+ + + AD VWE Sbjct 1213 AGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAAGDAGVVVWEPNP 1272 Query 1230 SFQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVR 1286 + +D VGPVY+ATH L LQSW +RAG LVVLT G+V G++ ++LAGAAVWG+VR Sbjct 1273 AGEDVVGPVYAATHAALEVLQSWFDGDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVR 1332 Query 1287 SAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNS 1346 SAQAE+PGR++LVD+D +++ +++ GE QL++R+G A+AARLA P + + S Sbjct 1333 SAQAENPGRIVLVDADAAVEAAELVAVGEPQLVVRSGAAHAARLAPAAPLLAVPADE--S 1390 Query 1347 GWRLVAGGAGALEDLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAA-EL 1403 WRL AGG G LEDL + CP + LA GQVR+ VRA+GVNFRDV+ ALG+YPGAA L Sbjct 1391 AWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMYPGAAPPL 1450 Query 1404 GAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVV 1463 GAEGAGVV EVGP V+G+AVGD VMG LG AG +VVD +L+ ++P W AA VPVV Sbjct 1451 GAEGAGVVLEVGPQVSGVAVGDSVMGFLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVV 1510 Query 1464 FLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMG 1523 FLTA + L+ LA++QPGESVL+HA GGVGMAAVQLAR WG+E+F TASRGKWDTL MG Sbjct 1511 FLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMG 1570 Query 1524 CDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 D+ H+ DSRTL FEE F T+GRGVDVVL+SLAG+F DASLRLL RGGRF+EMGKT+ Sbjct 1571 FDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMGKTDI 1630 >gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobacterium bovis AF2122/97] gi|31618823|emb|CAD96927.1| Probable polyketide synthase pks12 [Mycobacterium bovis AF2122/97] Length=4151 Score = 1748 bits (4528), Expect = 0.0, Method: Compositional matrix adjust. Identities = 959/1607 (60%), Positives = 1158/1607 (73%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 +AD + +GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 -AADAASLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA VQP Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLADVQP 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1480 bits (3832), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|118463404|ref|YP_882293.1| RifB protein [Mycobacterium avium 104] gi|48928158|gb|AAT47757.1| possible polyketide synthase [Mycobacterium avium] gi|118164691|gb|ABK65588.1| RifB protein [Mycobacterium avium 104] Length=2124 Score = 1747 bits (4524), Expect = 0.0, Method: Compositional matrix adjust. Identities = 977/1603 (61%), Positives = 1140/1603 (72%), Gaps = 28/1603 (1%) Query 1 MSGTTTH-VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELV 59 MSG T V L++ + R +R +EPVAVVGMGCRYPGGVDSPE LWE+V Sbjct 1 MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMGCRYPGGVDSPEALWEMV 60 Query 60 AQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALA 119 +GRD VS+FPADRGWD+ GLFD DPDA GK Y R G FL GDFDA FFGI PSEALA Sbjct 61 VEGRDVVSEFPADRGWDLAGLFDADPDAVGKSYCRCGGFLTGVGDFDAAFFGIAPSEALA 120 Query 120 MDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGS 177 MDPQQRLLLEVSWEALER GIDP LRGSATGVFAG+ H YGGQ + G LE YGL GS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPATLRGSATGVFAGIFHGSYGGQGRVPGNLERYGLRGS 180 Query 178 TLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPA 237 TLSVASGRVAY LGLEGPAVSVDTACSSSLVALHLA QSLRSGECDLALAGGVTVMATPA Sbjct 181 TLSVASGRVAYALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA 240 Query 238 AFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAV 297 F+EFSRQRALA DGRCK YAGAADGT +SEG GVLV+ERL DARRLGH VLA++RGSAV Sbjct 241 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHSVLAVLRGSAV 300 Query 298 NQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATY 357 NQDGASNGL PNGPSQQRVIRAALA+ARL A +VD+VEGHGTGTMLGDPIEAQALLATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEGHGTGTMLGDPIEAQALLATY 360 Query 358 GQDRV--EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSV 415 GQDR EPLWLGSIKSN+GHTSAAAG GVIKMVQA+RHGVMPKTLHVD PTP VDWS Sbjct 361 GQDRPVDEPLWLGSIKSNMGHTSAAAGAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSA 420 Query 416 GAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAAS-AV 474 GAVSLLT+ R W RPRRAGVSSFGISGTNAHVI+EQ PE +P V Sbjct 421 GAVSLLTEARPWPARDRPRRAGVSSFGISGTNAHVIVEQ------YEPETVAPQGGDVVV 474 Query 475 PWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALL 534 PWVLSARS +AL QA RLLA V A+P + +DVGWSLV TR+ FEHRAV+VGAD LL Sbjct 475 PWVLSARSAEALTNQAARLLARVKADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLL 534 Query 535 AGLAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAE 594 LA LA G+ GAGV GRA+ VGKTVFVFPGQG+QW GMGAQL +FA A Sbjct 535 RRLADLAGGQPGAGVVTGRAQPVGKTVFVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCAR 594 Query 595 ELDRHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVG 653 L H+ L +V+ A L + QPAL+A+ V+LA L + G+ PD +IGHS G Sbjct 595 ALAEHVDWSLIDVIRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQG 654 Query 654 EIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASE---EEVLPVLVDGANLA 710 EIAAA +AG LSL DAA +VA R RL+ L G MV +A E+++ + N+A Sbjct 655 EIAAACVAGALSLHDAARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGERLNIA 714 Query 711 AVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGIS 770 VN +VVVSG A++++ D A R R+ V +A HS+ +E + GI+ Sbjct 715 TVNGISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAEALRGIA 774 Query 771 VSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGG 830 + S VTG++ DG YW R+ V+F V+ G F+E P Sbjct 775 PRSSAVAFFSTVTGELMDTAALDGDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPV 834 Query 831 LTALVEQSLPL-GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIE 888 LTA +E+++P G+ + + R+ + F +G +DW A+ G GRR++ Sbjct 835 LTAAIEETMPDGGQGCVIPSLGRDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVD 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTY F RQ +WLP S GS+D++ +GL A HGLLGAV+ +PDS VVLTGRLS Q Sbjct 895 LPTYGFVRQHFWLPGGSTGSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSAQA 954 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGV- 1007 WLADH + VL GA FVELA+RA D+V CGV++ELT+ PL LP GGV+LQ+VVG Sbjct 955 WLADHAVGDTVLFPGAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVGAP 1014 Query 1008 GEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 E G+RP+S+YS A DS W+LHA GVL V PA DLS+WPP+GA VDV G Y R Sbjct 1015 DEAGRRPLSVYSAAAHQDSEWMLHAEGVLRTGTVTPAGDLSIWPPIGATAVDVTGGYARL 1074 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A+ GYEYGRAF+GL AMW+R E+FA+VA+PDD FG+HP++LDAALHA+G+ GE Sbjct 1075 AQRGYEYGRAFRGLRAMWQRGDEIFAEVALPDDA-AAGDDFGVHPVLLDAALHALGVAGE 1133 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 + T+LPFSWQGV+LHA+GASR R RIAPAG G VSVELAD AGLPVLSV+++ MR VS Sbjct 1134 KDQTVLPFSWQGVALHASGASRARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRPVSP 1193 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL-ESFQDGVGPVYSATHRVL 1246 LSAA+ A + GLL+V W P+ L ND+ ++ +WE E D V V++A L Sbjct 1194 GQLSAAMGTAQPS--GLLDVIWSPIALGGNDLGDEVTLWEPGEHGGDVVKSVHAAVTETL 1251 Query 1247 VALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDG 1303 LQSWL E AG L V T G+V G+D ++LAGAAVWGLVRSAQAEHPGR++L+DSDG Sbjct 1252 AVLQSWLDGEGAGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLVLIDSDG 1311 Query 1304 SMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 S+D VI CGE Q+++R G A+AARL R L LP + WRL AGG G L DL + Sbjct 1312 SLDARAVIPCGEPQVVVRQGVAHAARLRPARAGATLGLP--SGAWRLDAGGEGTLGDLVV 1369 Query 1364 ASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAV 1423 + CP ELA GQVR+ V A+GVNFRDVLVALG+YPG LGAEGAGVV EVGP VTGLAV Sbjct 1370 SRCPRTELADGQVRVAVAAVGVNFRDVLVALGMYPGGGRLGAEGAGVVVEVGPAVTGLAV 1429 Query 1424 GDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESV 1483 GDPVMGLLGV GSEAVVD RL+ +P L AAGVPVVFLTA Y L VL+ ++PGE V Sbjct 1430 GDPVMGLLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVLSGLRPGERV 1489 Query 1484 LVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWL 1543 LVH A GGVGMAAVQLAR +G EVFATASRGKWDTL MG D+ H+ DSR+ FE+ F Sbjct 1490 LVHTATGGVGMAAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRSPDFEQKFLA 1549 Query 1544 TTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 T G GVDVVLNSLAGEFTDASLRLL GGRFIEMGKT+ P Sbjct 1550 ATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDP 1592 >gi|254775560|ref|ZP_05217076.1| RifB protein [Mycobacterium avium subsp. avium ATCC 25291] Length=2124 Score = 1746 bits (4521), Expect = 0.0, Method: Compositional matrix adjust. Identities = 975/1603 (61%), Positives = 1139/1603 (72%), Gaps = 28/1603 (1%) Query 1 MSGTTTH-VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELV 59 MSG T V L++ + R +R +EPVAVVGMGCRYPGGVDSPE LWE+V Sbjct 1 MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMGCRYPGGVDSPEALWEMV 60 Query 60 AQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALA 119 +GRD VS+FPADRGWD+ GLFD DPDA GK Y R G FL GDFDA FFGI PSEALA Sbjct 61 VEGRDVVSEFPADRGWDLAGLFDADPDAVGKSYCRCGGFLTGVGDFDAAFFGIAPSEALA 120 Query 120 MDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGS 177 MDPQQRLLLEV WEALER GIDP LRGSATGVFAG+ H YGGQ + G LE YGL GS Sbjct 121 MDPQQRLLLEVCWEALERAGIDPATLRGSATGVFAGIFHGSYGGQGRVPGNLERYGLRGS 180 Query 178 TLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPA 237 TLSVASGRVAY LGLEGPAVSVDTACSSSLVALHLA QSLRSGECDLALAGGVTVMATPA Sbjct 181 TLSVASGRVAYALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA 240 Query 238 AFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAV 297 F+EFSRQRALA DGRCK YAGAADGT +SEG GVLV+ERL DARRLGH VLA++RGSAV Sbjct 241 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHSVLAVLRGSAV 300 Query 298 NQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATY 357 NQDGASNGL PNGPSQQRVIRAALA+ARL A +VD+VEGHGTGTMLGDPIEAQALLATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEGHGTGTMLGDPIEAQALLATY 360 Query 358 GQDRV--EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSV 415 GQDR EPLWLGSIKSN+GHTSAAAG GVIKMVQA+RHGVMPKTLHVD PTP VDWS Sbjct 361 GQDRPVDEPLWLGSIKSNMGHTSAAAGAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSA 420 Query 416 GAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAAS-AV 474 GAVSLLT+ R W RPRRAGVSSFGISGTNAHVI+EQ PE +P V Sbjct 421 GAVSLLTEARPWPARDRPRRAGVSSFGISGTNAHVIVEQ------YEPETVAPQGGDVVV 474 Query 475 PWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALL 534 PWVLSARS +AL QA RLLA V A+P + +DVGWSLV TR+ FEHRAV+VGAD LL Sbjct 475 PWVLSARSAEALTNQAARLLARVKADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLL 534 Query 535 AGLAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAE 594 LA LA G+ GAGV GRA+ VGKTVFVFPGQG+QW GMGAQL +FA A Sbjct 535 RRLADLAGGQPGAGVVTGRAQPVGKTVFVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCAR 594 Query 595 ELDRHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVG 653 L H+ L +V+ A L + QPAL+A+ V+LA L + G+ PD +IGHS G Sbjct 595 ALAEHVDWSLIDVIRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQG 654 Query 654 EIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASE---EEVLPVLVDGANLA 710 EIAAA +AG LSL DAA +VA R RL+ L G MV +A E+++ + N+A Sbjct 655 EIAAACVAGALSLQDAARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGERLNIA 714 Query 711 AVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGIS 770 VN +VVVSG A++++ D A R R+ V +A HS+ +E + GI+ Sbjct 715 TVNGISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAEALRGIA 774 Query 771 VSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGG 830 + S VTG++ DG YW R+ V+F V+ G F+E P Sbjct 775 PRSSAVAFFSTVTGELMDTAALDGDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPV 834 Query 831 LTALVEQSLPL-GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIE 888 LTA +E+++P G+ + + R+ + F +G +DW A G GRR++ Sbjct 835 LTAAIEETMPDGGQGCVIPSLGRDDGAPDRFWLSAGQAFVSGVVVDWCATLDGLGGRRVD 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTY F RQ +WLP S GS+D++ +GL A HGLLGAV+ +PDS VVLTGRLS Q Sbjct 895 LPTYGFVRQHFWLPGGSTGSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSAQA 954 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGV- 1007 WLADH + VL GA FVELA+RA D+V CGV++ELT+ PL LP GGV+LQ+VVG Sbjct 955 WLADHAVGDTVLFPGAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVGAP 1014 Query 1008 GEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 E G+RP+S+YS A DS W+LHA GVL A V PA DLS+WPP+GA VDV G Y R Sbjct 1015 DEAGRRPLSVYSAAAHQDSEWMLHAEGVLRAGTVTPAGDLSIWPPIGATAVDVTGGYARL 1074 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A+ GYEYGRAF+GL AMW+R E+FA+V++PDD FG+HP++LDAALHA+G+ GE Sbjct 1075 AQRGYEYGRAFRGLRAMWQRGDEIFAEVSLPDDA-AAGDDFGVHPVLLDAALHALGVAGE 1133 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 + T+LPF+WQGV+LHA+GA+R R RIAPAG G VSVELAD AGLPVLSV+++ MR VS Sbjct 1134 KDQTVLPFAWQGVALHASGAARARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRPVSP 1193 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL-ESFQDGVGPVYSATHRVL 1246 LSAA+ A + GLL+V W P+ L ND+ ++ +WE E D V V++A L Sbjct 1194 GQLSAAMGTAQPS--GLLDVIWSPIALGGNDLGDEVTLWEPGEHGGDVVKSVHAAVTETL 1251 Query 1247 VALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDG 1303 LQSWL E AG L V T G+V G+D ++LAGAAVWGLVRSAQAEHPGR++L+DSDG Sbjct 1252 AVLQSWLDGEGAGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLVLIDSDG 1311 Query 1304 SMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 S+D VI CGE Q+++R G A+AARL R L LP + WRL AGG G L DL + Sbjct 1312 SLDARAVIPCGEPQVVVRQGVAHAARLRPARAGATLGLP--SGAWRLDAGGEGTLGDLVV 1369 Query 1364 ASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLAV 1423 + CP ELA GQVR+ V A+GVNFRDVLVALG+YPG LGAEGAGVV EVGP VTGLAV Sbjct 1370 SRCPRTELADGQVRVAVAAVGVNFRDVLVALGMYPGGGRLGAEGAGVVVEVGPAVTGLAV 1429 Query 1424 GDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESV 1483 GDPVMGLLGV GSEAVVD RL+ +P L AAGVPVVFLTA Y L VLA ++PGE V Sbjct 1430 GDPVMGLLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVLAGLRPGERV 1489 Query 1484 LVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWL 1543 LVH A GGVGMAAVQLAR +G EVFATASRGKWDTL MG D+ H+ DSR+ FE+ F Sbjct 1490 LVHTATGGVGMAAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRSPDFEQKFLA 1549 Query 1544 TTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 T G GVDVVLNSLAGEFTDASLRLL GGRFIEMGKT+ P Sbjct 1550 ATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDP 1592 >gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|13881781|gb|AAK46387.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] Length=4151 Score = 1735 bits (4493), Expect = 0.0, Method: Compositional matrix adjust. Identities = 957/1607 (60%), Positives = 1154/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R LA Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHRGLA 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV+++ Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGP- 3223 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3224 -DRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1480 bits (3832), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSGSGP--DRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|289554169|ref|ZP_06443379.1| polyketide synthase Pks12 [Mycobacterium tuberculosis KZN 605] gi|289438801|gb|EFD21294.1| polyketide synthase Pks12 [Mycobacterium tuberculosis KZN 605] Length=2730 Score = 1732 bits (4487), Expect = 0.0, Method: Compositional matrix adjust. Identities = 956/1607 (60%), Positives = 1154/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 612 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 671 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GLFDPDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQ R+LLE Sbjct 672 PADRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLE 731 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 732 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 791 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 792 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 851 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 852 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 911 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 912 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 971 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 972 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 1031 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 1032 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 1087 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 1088 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 1146 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 1147 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 1206 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 1207 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 1266 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 1267 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 1326 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 1327 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 1386 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 1387 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 1446 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 1447 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 1505 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 1506 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 1564 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 1565 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 1623 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 1624 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 1683 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 1684 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 1743 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 1744 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 1801 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 1802 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 1861 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 1862 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 1921 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 1922 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 1981 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 1982 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 2041 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 2042 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 2101 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 2102 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 2161 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 2162 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 2208 Score = 202 bits (513), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 105/178 (59%), Positives = 126/178 (71%), Gaps = 1/178 (0%) Query 1410 VVTEVGPGVTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAY 1468 +V EVGPGVT +VGD V G +G+ D RL++ +P W +AA + VF TAY Sbjct 1 MVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAY 60 Query 1469 YALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTH 1528 YA LA VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H Sbjct 61 YAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDH 120 Query 1529 VADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 ++DSR+L FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 121 ISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 178 >gi|339298599|gb|AEJ50709.1| polyketide synthase Pks12 [Mycobacterium tuberculosis CCDC5180] Length=2617 Score = 1731 bits (4482), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 499 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 558 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 559 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 618 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 619 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 678 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 679 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 738 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 739 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 798 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 799 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 858 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 859 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 918 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 919 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 974 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 975 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 1033 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 1034 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 1093 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 1094 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 1153 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 1154 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 1213 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 1214 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 1273 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 1274 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 1333 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 1334 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 1392 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 1393 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 1451 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 1452 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 1510 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 1511 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 1570 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 1571 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 1630 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 1631 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 1688 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 1689 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 1748 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 1749 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 1808 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 1809 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 1868 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 1869 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 1928 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 1929 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 1988 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 1989 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 2048 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 2049 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 2095 Score = 85.5 bits (210), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 40/65 (62%), Positives = 49/65 (76%), Gaps = 0/65 (0%) Query 1522 MGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKT 1581 MG D+ H++DSR+L FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT Sbjct 1 MGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKT 60 Query 1582 EFGTP 1586 + P Sbjct 61 DIRDP 65 >gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_11001 [Mycobacterium tuberculosis KZN R506] Length=4152 Score = 1730 bits (4481), Expect = 0.0, Method: Compositional matrix adjust. Identities = 956/1607 (60%), Positives = 1154/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2034 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2093 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GLFDPDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQ R+LLE Sbjct 2094 PADRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLE 2153 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2154 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2213 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2214 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2273 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2274 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2333 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2334 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2393 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2394 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2453 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2454 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2509 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2510 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2568 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2569 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2628 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2629 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2688 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2689 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2748 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2749 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2808 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2809 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2868 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2869 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2927 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2928 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2986 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2987 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3045 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3046 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3105 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3106 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3165 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3166 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3223 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3224 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3283 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3284 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3343 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3344 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3403 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3404 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3463 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3464 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3523 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3524 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3583 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3584 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3630 Score = 1484 bits (3841), Expect = 0.0, Method: Compositional matrix adjust. Identities = 878/1610 (55%), Positives = 1068/1610 (67%), Gaps = 42/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPDA G YTR G F++ GDFD FFG+GPSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSS 181 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 182 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 241 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 242 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 301 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 302 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 361 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 362 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 421 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 422 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 477 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 478 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 536 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 537 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 596 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 597 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 656 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 657 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 716 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 717 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 776 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 777 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 836 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 837 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 895 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 896 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 954 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 955 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1014 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1015 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1073 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1074 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1132 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1133 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1192 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1193 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1250 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1251 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1310 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1311 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1370 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1371 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1430 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1431 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1490 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1491 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1550 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1551 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1600 >gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] gi|148721791|gb|ABR06416.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] Length=4151 Score = 1730 bits (4481), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1481 bits (3835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_10901 [Mycobacterium tuberculosis KZN 4207] gi|313658946|ref|ZP_07815826.1| hypothetical protein MtubKV_11016 [Mycobacterium tuberculosis KZN V2475] Length=4152 Score = 1730 bits (4480), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2034 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2093 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2094 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2153 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2154 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2213 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2214 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2273 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2274 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2333 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2334 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2393 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2394 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2453 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2454 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2509 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2510 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2568 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2569 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2628 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2629 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2688 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2689 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2748 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2749 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2808 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2809 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2868 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2869 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2927 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2928 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2986 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2987 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3045 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3046 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3105 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3106 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3165 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3166 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3223 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3224 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3283 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3284 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3343 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3344 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3403 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3404 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3463 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3464 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3523 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3524 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3583 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3584 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3630 Score = 1484 bits (3842), Expect = 0.0, Method: Compositional matrix adjust. Identities = 878/1610 (55%), Positives = 1068/1610 (67%), Gaps = 42/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPDA G YTR G F++ GDFD FFG+GPSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSS 181 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 182 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 241 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 242 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 301 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 302 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 361 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 362 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 421 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 422 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 477 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 478 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 536 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 537 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 596 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 597 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 656 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 657 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 716 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 717 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 776 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 777 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 836 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 837 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 895 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 896 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 954 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 955 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1014 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1015 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1073 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1074 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1132 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1133 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1192 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1193 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1250 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1251 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1310 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1311 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1370 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1371 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1430 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1431 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1490 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1491 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1550 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1551 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1600 >gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycobacterium tuberculosis 210] Length=4151 Score = 1730 bits (4480), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1481 bits (3834), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990428|ref|YP_002645115.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|121493581|emb|CAL72055.1| Probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224773541|dbj|BAH26347.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601971|emb|CCC64645.1| probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Moreau RDJ] Length=4151 Score = 1730 bits (4480), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPRVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGLAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1482 bits (3836), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] gi|289420626|gb|EFD17827.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] Length=4151 Score = 1729 bits (4479), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1481 bits (3833), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|253320398|gb|ACT25001.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|328458652|gb|AEB04075.1| polyketide synthase pks12 [Mycobacterium tuberculosis KZN 4207] gi|344219874|gb|AEN00505.1| polyketide synthase pks12 [Mycobacterium tuberculosis CTRI-2] Length=4152 Score = 1729 bits (4479), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2034 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2093 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2094 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2153 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2154 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2213 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2214 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2273 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2274 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2333 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2334 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2393 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2394 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2453 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2454 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2509 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2510 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2568 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2569 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2628 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2629 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2688 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2689 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2748 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2749 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2808 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2809 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2868 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2869 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2927 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2928 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2986 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2987 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3045 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3046 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3105 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3106 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3165 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV+++ Sbjct 3166 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGP- 3224 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3225 -DRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3283 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3284 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3343 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3344 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3403 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3404 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3463 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3464 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3523 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3524 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3583 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3584 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3630 Score = 1484 bits (3842), Expect = 0.0, Method: Compositional matrix adjust. Identities = 878/1610 (55%), Positives = 1068/1610 (67%), Gaps = 42/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPDA G YTR G F++ GDFD FFG+GPSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSS 181 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 182 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 241 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 242 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 301 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 302 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 361 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 362 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 421 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 422 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 477 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 478 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 536 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 537 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 596 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 597 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 656 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 657 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 716 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 717 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 776 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 777 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 836 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 837 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 895 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 896 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 954 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 955 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1014 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1015 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1073 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1074 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1132 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1133 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1192 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1193 RQLLAAVSGSGP--DRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1250 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1251 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1310 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1311 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1370 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1371 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1430 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1431 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1490 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1491 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1550 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1551 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1600 >gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|298495345|gb|EFI30639.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=4151 Score = 1729 bits (4479), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1481 bits (3835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDDVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289574727|ref|ZP_06454954.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339632088|ref|YP_004723730.1| polyketide synthase [Mycobacterium africanum GM041182] gi|124601277|gb|EAY60287.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289539158|gb|EFD43736.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339331444|emb|CCC27133.1| putative polyketide synthase pks12 [Mycobacterium africanum GM041182] Length=4151 Score = 1729 bits (4479), Expect = 0.0, Method: Compositional matrix adjust. Identities = 955/1607 (60%), Positives = 1155/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1481 bits (3833), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] gi|148506014|gb|ABQ73823.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] Length=4151 Score = 1728 bits (4475), Expect = 0.0, Method: Compositional matrix adjust. Identities = 954/1607 (60%), Positives = 1154/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQ R+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1477 bits (3825), Expect = 0.0, Method: Compositional matrix adjust. Identities = 878/1610 (55%), Positives = 1066/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVW P GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWAPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|340627059|ref|YP_004745511.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] gi|340005249|emb|CCC44403.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] Length=4154 Score = 1727 bits (4473), Expect = 0.0, Method: Compositional matrix adjust. Identities = 954/1607 (60%), Positives = 1154/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2036 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2095 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 P DRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQQR+LLE Sbjct 2096 PGDRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQQRMLLE 2155 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2156 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2215 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2216 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2275 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2276 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2335 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2336 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2395 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2396 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2455 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2456 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2511 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2512 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2570 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2571 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2630 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2631 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2690 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2691 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2750 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2751 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGIISNVTGQL 2810 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2811 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2870 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2871 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2929 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2930 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2988 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+ELT+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2989 VELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3047 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3048 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3107 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3108 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3167 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV+++ Sbjct 3168 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSGP- 3226 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3227 -DRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3285 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3286 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3345 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3346 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3405 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3406 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3465 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3466 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3525 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3526 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3585 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3586 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3632 Score = 1474 bits (3816), Expect = 0.0, Method: Compositional matrix adjust. Identities = 880/1613 (55%), Positives = 1065/1613 (67%), Gaps = 46/1613 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 +GRD +S FP DRGWD+ GLFDPDPDA K Y R G F++ DFD FFGI PSEALAM Sbjct 62 EGRDVISGFPTDRGWDLAGLFDPDPDARHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK Y GAADG WSEG G+L +ERL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYGGAADGVGWSEGGGMLALERLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATPAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVRPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIALCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRP 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG +DW G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSTASAFVAGVAVDWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSD---VVVLTGRLSVG 945 LPTYAF ++R+WL +G AD G+GL A+ H LLGAVV+ P S ++VLTGRLS Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADAFGLGLGASEHPLLGAVVDLPASGGMVLMVLTGRLSPN 953 Query 946 EQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV 1005 Q WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV Sbjct 954 VQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVV 1013 Query 1006 GVG-EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAY 1064 G + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y Sbjct 1014 DAGRDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVAVDVADGY 1072 Query 1065 QRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGM 1124 +R A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + Sbjct 1073 ERLATCGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1131 Query 1125 VGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRS 1184 G+ LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R Sbjct 1132 AGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARP 1191 Query 1185 VSSQLLSAAVAAADAAGRGLLEVAWLPVE--LAHNDISADLVVWELESFQDGVGPVYSAT 1242 V+ + L AAV+ + L EV W A A + + + QD V Y + Sbjct 1192 VTERQLLAAVSGSGP--DRLFEVIWSRASGVTALGSTPAYQIFESVAADQDPVAGSYVRS 1249 Query 1243 HRVLVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV 1299 H+ L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 HQALAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLV 1309 Query 1300 ---DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAG 1356 + + + GE Q+++R G Y AR+ R + +P + WRL G AG Sbjct 1310 DSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAG 1369 Query 1357 ALEDLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEV 1414 E+L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EV Sbjct 1370 TFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEV 1429 Query 1415 GPGVTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRV 1473 GPGVT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA Sbjct 1430 GPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIH 1489 Query 1474 LAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSR 1533 LA VQPG+ VL+HAA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR Sbjct 1490 LADVQPGQRVLIHAATGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSR 1549 Query 1534 TLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 +L FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 SLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1602 >gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] gi|2896785|emb|CAA17262.1| Probable polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] Length=4151 Score = 1725 bits (4468), Expect = 0.0, Method: Compositional matrix adjust. Identities = 953/1607 (60%), Positives = 1153/1607 (72%), Gaps = 40/1607 (2%) Query 10 YLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDF 69 Y++ A L + + + +P+A+VGM CRYPGGV+SP+ +W+++ QGRD +S+F Sbjct 2033 YIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEF 2092 Query 70 PADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLE 129 PADRGWD+ GL++PDPDA G YTR G F++ GDFD FFG+GPSEALAMDPQ R+LLE Sbjct 2093 PADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLE 2152 Query 130 VSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYV 189 +SWEALER GIDPT LRGSATGVFAGV+ GYG + +EG+ LTG SVASGRVAYV Sbjct 2153 LSWEALERAGIDPTGLRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYV 2212 Query 190 LGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALA 249 LGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FVEFSR R L+ Sbjct 2213 LGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLS 2272 Query 250 RDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAP 309 DGRCK +A AADGT +SEG G+LV++RL DARRLGHPVLA+V GSAVNQDGASNGLTAP Sbjct 2273 PDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTAP 2332 Query 310 NGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDR---VEPLW 366 NGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQDR EPLW Sbjct 2333 NGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQDRGEPGEPLW 2392 Query 367 LGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRA 426 LGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GAV LLT PR Sbjct 2393 LGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRV 2452 Query 427 WSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQAL 486 W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV+SA+SE AL Sbjct 2453 WPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWVVSAKSESAL 2508 Query 487 AGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESG 546 GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL LA + G Sbjct 2509 RGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGLDELAGDQLG 2567 Query 547 AGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRN 606 V G A + GKTVFVFPGQG+QW+GMG L+A P+FA AF+ V ELDRHL PLR Sbjct 2568 GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLRE 2627 Query 607 VLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSL 666 V+W DE LL STEFAQPALFA+EVAL LL WG+ PDF++GHS+GE++AAH+AGVLSL Sbjct 2628 VMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL 2687 Query 667 TDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAA 726 +AA LVAARGRLM LPAGG MV V A+EEEV P+L ++AAVN P S+V+SG + A Sbjct 2688 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPASLVISGAQNA 2747 Query 727 VSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQM 786 V+ +AD GRRVH+LAVSHAFHS LM+PM+ EF +AAGI++ +P I ++SNVTGQ+ Sbjct 2748 VAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVISNVTGQL 2807 Query 787 AGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALS 846 AG +G YW H R+ VRFA+ V+ A G +RF+EVGP GGL A +E+SLP + Sbjct 2808 AGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTT 2867 Query 847 VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSA 906 ++ +R++ PE +++ AVA F G +DW AV G + +ELPTYAFQR+R+WL Sbjct 2868 MSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGE-AQFVELPTYAFQRRRFWLSGDGV 2926 Query 907 GSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAF 966 + +G+GL A+ H LLGAV++ P S VVLTGRLS Q WLADH +AGV + GA F Sbjct 2927 AAD-AAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGF 2985 Query 967 VELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVV-GVGEMGQRPVSIYSRNAESD 1025 VELA+RA D+V CGVV+E T+ PLVLP G V +QVVV G E G R VS+YSR + Sbjct 2986 VELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGPDESGVRGVSVYSRG-DVG 3044 Query 1026 SGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMW 1085 +GWVLHA G L A + P ADL++WPP GA PV+V YQ+ AE GY YG AF+GLTAMW Sbjct 3045 TGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRGLTAMW 3104 Query 1086 RRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE-----QAATMLPFSWQGV 1140 RR E+FA+VA+P D V+++GFG+HP++LDAALHA+ + E Q + ++PFSWQGV Sbjct 3105 RRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGSVLVPFSWQGV 3164 Query 1141 SLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAADAA 1200 SLHAAGAS VRARIAP G VS+ELAD GLPVLSV +++ R V+ Q L AAV++ + Sbjct 3165 SLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSS--SG 3222 Query 1201 GRGLLEVAWLPVELA-----------HNDISADLVVWELESFQDGVGPVYSATHRVLVAL 1249 L EV W P A + SA +V + D V VY+AT VL L Sbjct 3223 PDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVL 3282 Query 1250 QSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD 1306 QSWL ++ AG LVV+T+G+V G+D T+LAGAAVWGLVRSAQ EHPGR++LVDSD +D Sbjct 3283 QSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLD 3342 Query 1307 ---VGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTL 1363 + V+ GE Q++ R G Y AR+ R L +P ++ WRL AG E+L L Sbjct 3343 DSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRL 3402 Query 1364 ASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTG 1420 P + L PGQVR+ V A+ NFRDV++ALG+YP A +G E GVV E Sbjct 3403 ELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPDPDAVMGVEACGVVIETSLNKGS 3462 Query 1421 LAVGDPVMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQP 1479 AVGD VMGL G+ A D RL+VK+P W T AA VVF TA+YAL LA + Sbjct 3463 FAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARS 3522 Query 1480 GESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEE 1539 G+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L FE+ Sbjct 3523 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFED 3582 Query 1540 TFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 3583 KFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 3629 Score = 1481 bits (3833), Expect = 0.0, Method: Compositional matrix adjust. Identities = 879/1610 (55%), Positives = 1067/1610 (67%), Gaps = 43/1610 (2%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 RD +S+FP DRGWD+ GLFDPDPD K Y R G F++ DFD FFGI PSEALAM Sbjct 62 DARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER GIDPT LRGSATGVFAG+I GYG L+ E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGLIVGGYG-MLAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AV SLRSGECDLALAGGVTV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGRCK YAG ADG WSEG G+LV++RL DARRLGHPVLA+V GSAVNQD Sbjct 241 EFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R---VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGA 417 R EPLWLGS+KSN+GHT AAAGVAGVIKMV AMRH ++P TLHVDVP+PHVDWS GA Sbjct 361 RGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGA 420 Query 418 VSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWV 477 V LLT PR W R RRAGVSSFGISGTNAHVI+E P VVP + A VPWV Sbjct 421 VELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVP----VVPRREAGWAGPVVPWV 476 Query 478 LSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGL 537 +SA+SE AL GQA RL A+V + LD DVGWSL R++FEHRAVVVG DR LLAGL Sbjct 477 VSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRLLAGL 535 Query 538 AALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELD 597 LA + G V G A + GKTVFVFPGQG+QW+GMG +L P FA DA AE Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 598 RHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 + L +VL A L + QP LFA+ V+LA L + + PD +IGHS GEIA Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLV---DGANLAAVN 713 AA++AG LSL DAA +V R +L+A L G MV +A ++ +L D ++A VN Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 714 APHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSK 773 P +VVVSG A+ ++ + + R R+ V +A HS+ +E + +GI Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 774 PRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTA 833 R S VTG D YW + R+ V F + V+ G F+E P L Sbjct 776 TRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALIT 835 Query 834 LVEQSLPL-----GEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGSPGRRIE 888 VE++ EA+ V + R + L + A+ F AG ++W G +E Sbjct 836 GVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG-YVE 894 Query 889 LPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQR 948 LPTYAF ++R+WL +G AD+SG+GL A+ H LLGAVV+ P S VVLTGRLS Q Sbjct 895 LPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQP 953 Query 949 WLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVG 1008 WLADH ++ VVL G FVELA+RA D+V C V++ELT+ PL+LP G V +QVVV G Sbjct 954 WLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAG 1013 Query 1009 -EMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRF 1067 + R VSI+SR A++ +GW+LHA G+L +V P ADLSVWPP GA VDV Y+R Sbjct 1014 RDSNSRGVSIFSR-ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERL 1072 Query 1068 AELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGE 1127 A GY YG AF+GLTAMW R E+FA+V +P + + GFG+HP +LDA LHA+ + G+ Sbjct 1073 ATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVIAGD 1131 Query 1128 QAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS 1187 LPF+WQGVSLHA GAS VRARIAPAG VSVELAD GLPVLSV ++V R V+ Sbjct 1132 PDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE 1191 Query 1188 QLLSAAVAAADAAGRGLLEVAWLPVELAHN--DISADLVVWELESFQDGVGPVYSATHRV 1245 + L AAV+ + L EV W P A + A + + + QD V Y +H+ Sbjct 1192 RQLLAAVSG--SGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQA 1249 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLV--- 1299 L A+QSWL +G LVV T+G++ +D +LAGAAVWGLVRSAQ EHPGR++LV Sbjct 1250 LAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSD 1309 Query 1300 DSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALE 1359 + + + GE Q+++R G Y AR+ R + +P + WRL G AG E Sbjct 1310 AATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFE 1369 Query 1360 DLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 +L L P + L PGQVR+ +RA+ NFRD+++ LG++ A LG EGAGVV EVGPG Sbjct 1370 NLRLEPVPNADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPG 1429 Query 1418 VTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQ 1476 VT +VGD V G +G+ D RL++ +P W +AA + VF TAYYA LA Sbjct 1430 VTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLAD 1489 Query 1477 VQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLA 1536 VQPG+ VL+HA GGVGMAAVQLAR GLEVFATAS+GKWDTL MG D+ H++DSR+L Sbjct 1490 VQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLE 1549 Query 1537 FEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 FE+ F T GRG DVVL+SLAGEF DASLRL+ GG F+EMGKT+ P Sbjct 1550 FEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDP 1599 >gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] gi|118569895|gb|ABL04646.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] Length=4191 Score = 1713 bits (4437), Expect = 0.0, Method: Compositional matrix adjust. Identities = 940/1598 (59%), Positives = 1148/1598 (72%), Gaps = 55/1598 (3%) Query 34 EPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYT 93 +P+A+VGM CRYPGG++SP+ LW+++ RD +SDFPADRGWD+ GLF+PDPD G YT Sbjct 2075 DPIAIVGMSCRYPGGIESPDDLWDMLMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYT 2134 Query 94 RRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLEVSWEALERTGIDPTKLRGSATGVF 153 R G F++ GDF+ FFG+GPSEALAMDPQQR+ LE+SWEALER GI+P LRGSATGVF Sbjct 2135 RTGGFVDRVGDFEPAFFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVF 2194 Query 154 AGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLA 213 AGV+ GYG + +EG+ LTG SVASGRVAYVLGLEGPAVSVDTACSSSLVALH+A Sbjct 2195 AGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMA 2254 Query 214 VQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVL 273 VQSLRSGECDLALAGGVT+ ATP FVEFSR R L+ DGRCK +AGAADGT +SEG G+L Sbjct 2255 VQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFAGAADGTGFSEGGGML 2314 Query 274 VVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVD 333 VVERL DA+RLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRV+RAALA+A L A EVD Sbjct 2315 VVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVD 2374 Query 334 VVEGHGTGTMLGDPIEAQALLATYGQDR------VEPLWLGSIKSNIGHTSAAAGVAGVI 387 VVEGHGTGT LGDPIEAQALLATYGQDR + LWLGSIKSN+GHT AAAGVAGVI Sbjct 2375 VVEGHGTGTTLGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI 2434 Query 388 KMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW---SVHGRPRRAGVSSFGIS 444 KMVQAMRH V+P TLHVDVP+PHVDWS GAV LLT+ + W S R RRAGVSSFGIS Sbjct 2435 KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGIS 2494 Query 445 GTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQALAGQAQRLLAFVAANPDLD 504 GTNAHVI+E AP VE +S A VPWV+SA+S AL QA RL A V ++ +LD Sbjct 2495 GTNAHVIVEAAPRVEV---GGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVRSHDELD 2551 Query 505 PIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE-SGAGVAVGRARSVGKTVFV 563 DVGWSL R+ FEHRAVV+GADR LLAGL LA E GA V G A + GKTVFV Sbjct 2552 VADVGWSLAG-RSTFEHRAVVLGADRDGLLAGLDELAGDEFGGASVIRGVAGAAGKTVFV 2610 Query 564 FPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQ 623 FPGQG+Q +GMG L+A P+FA AF+ V ELDRHL PLR V+W DE LL +TEFAQ Sbjct 2611 FPGQGSQLLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVIWGHDENLLNTTEFAQ 2670 Query 624 PALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAEL 683 PALFA+EVAL LL+ WG+ PDF++GHSVGE++AAH+AGVLSL +AA LVAARGRLM L Sbjct 2671 PALFAVEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGRLMQAL 2730 Query 684 PAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHR 743 P GG M+ V A+E+EVLP+L ++A +N P SVV+SG + AVS +A+ GRRVHR Sbjct 2731 PDGGAMIAVQATEQEVLPLLGAQVSIATINGPASVVISGAQDAVSAVAEQLRADGRRVHR 2790 Query 744 LAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARR 803 LAVSHAFHS LM+PM+ EF +A ++V+ P I ++SN+TGQ+AG +G YW H R Sbjct 2791 LAVSHAFHSPLMDPMIDEFATVAGELTVNAPTIGIISNLTGQLAGEDFGSAAYWKRHVRD 2850 Query 804 PVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP----LGEALSVAMMRREHPEVSS 859 VRFA+ ++ + GA RF+EVGP GLTA +E+ L + + +R++ PE S Sbjct 2851 AVRFADSIRFAQSAGAARFLEVGPSIGLTASIEEVLSDAAVTNPVATASALRKDRPEPVS 2910 Query 860 VLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAA 919 ++ A+A +F AG +DW AV G +ELPTYAF+R+R+WL A AD +G+GL A Sbjct 2911 LVSALAGVFVAGTAVDWRAVVGQ-SHFVELPTYAFERRRFWL-SGDAVPADAAGLGLQAG 2968 Query 920 RHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDC 979 H LLGAVVE P S VVLTGRLS+ Q WLADH + GVV+ GA FVELA+RA D+V C Sbjct 2969 EHALLGAVVELPASGGVVLTGRLSLAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGC 3028 Query 980 GVVEELTVVTPLVLPTVGGVQLQVVVGV-GEMGQRPVSIYSRNAESDSGWVLHARGVLGA 1038 VV+ELT+ PLVLP+ G V +QVVVG + G R VS+YSR ++ S WVLHA G LG+ Sbjct 3029 RVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVSVYSRG-DAGSDWVLHAEGSLGS 3087 Query 1039 KAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVP 1098 + PA DLS WPP+GA V+ YQ+ AE GY YG AF+GL AMWRR E+FA+VA+P Sbjct 3088 GSPEPATDLSTWPPVGAVEVENADGYQQLAERGYGYGPAFRGLNAMWRRGDEVFAEVALP 3147 Query 1099 DDVDVTLSGFGIHPLVLDAALHAMGMVGE--------QAATMLPFSWQGVSLHAAGASRV 1150 D V++SGFGIHP++LDAALHA+ + + + + ++PF+WQGV+LHAAGAS V Sbjct 3148 ADAGVSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHAAGASAV 3207 Query 1151 RARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAA--------DAAGR 1202 RARIAPAG VS+EL+D GLPVLSV +++ R V+ Q L AAV+ A D + Sbjct 3208 RARIAPAGPSAVSIELSDGLGLPVLSVASMLARPVTDQQLRAAVSGAGPDRLFGVDWTAQ 3267 Query 1203 GLLEVAWLPVEL-------AHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQ 1255 E+ +PV + +D A +V + + V VY+AT VL L+SWL++ Sbjct 3268 PSAELQPVPVRIWGTVESEGDDDPGASVVFESVPQAGEVVAGVYAATAAVLEVLRSWLSR 3327 Query 1256 ERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD---VGD 1309 + AG+L++ T+G+V +D T+LAG+AVWGLVRSAQ EHPGR++LVD+D +D V Sbjct 3328 DGAGQLIITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPGRIVLVDTDAQLDEHAVAA 3387 Query 1310 VIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAK 1369 V+ GE Q++ RNG Y AR+ R L +P + WRL AG E+L L P Sbjct 3388 VLAAGEPQVLWRNGEVYTARVHGSRAVAGLLVPPGDGPWRLGMSTAGTFENLRLEPIPDA 3447 Query 1370 E--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTGLAVGDP 1426 + L PG VR+ + A+ NFRDV++ALG+YP A +G EGAGVV E AVGD Sbjct 3448 DAALQPGHVRVALSAMAANFRDVMIALGLYPDPDAAMGVEGAGVVVETASPDGRFAVGDR 3507 Query 1427 VMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLV 1485 V+GL G+ A+ D RL+VK+P W T AA VVF TA+YALR LA VQPG+ +LV Sbjct 3508 VVGLFPEGTGTIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV 3567 Query 1486 HAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTT 1545 HAA GGVGMAAVQLAR WGLEVFATAS+GKWDTL MG D H+ DSR+L FE+ F T Sbjct 3568 HAATGGVGMAAVQLARHWGLEVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAAT 3627 Query 1546 EGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 GRG+DVVL+SLAGEF DASLRL+ GG F+EMGKT+ Sbjct 3628 GGRGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDI 3665 Score = 1523 bits (3942), Expect = 0.0, Method: Compositional matrix adjust. Identities = 890/1622 (55%), Positives = 1073/1622 (67%), Gaps = 53/1622 (3%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 +GRD +SDFP DRGWD+ LFDPDPD K Y G F++ DFD GFFGI PSEALAM Sbjct 62 EGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGFVDGVADFDPGFFGIAPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER+GIDPT LRGSATGVFAG+I GY G + E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERSGIDPTGLRGSATGVFAGLIVQGY-GMFAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AVQSLRSGECDLALAGG TV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGR K YAGAADG WSEG +LVVERL DA+RLGHPVLALVRGSAVNQD Sbjct 241 EFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R------VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWS 414 R + LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH V+P TLHVDVP+PHVDWS Sbjct 361 RGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWS 420 Query 415 VGAVSLLTQPRAW---SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAA 471 GAV LLT+ + W S R RRAGVSSFGISGTNAHVI+E AP VE +S A Sbjct 421 AGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAPRVEV---GGSSGGAV 477 Query 472 SAVPWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRG 531 VPWV+SA+S AL QA RL A V ++ +LD DVGWSL R+ FEHRAVV+GADR Sbjct 478 PVVPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRD 536 Query 532 ALLAGLAALAAGE-SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFD 590 LLAGL LA E GA V G A + GKTVFVFPGQG+QW+GMG +L P+FA + Sbjct 537 GLLAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTAPVFARHIE 596 Query 591 AVAEELDRHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIG 649 + + + L +VL A L + QP LFA+ V+LA L + G+ PD +IG Sbjct 597 SCGQAFAEFVDWSLLDVLRGAAGAPGLDRIDVVQPVLFAVMVSLAELWKSVGVRPDAVIG 656 Query 650 HSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEE---EVLPVLVDG 706 HS GEIAAA++AG LSL DAA +V R +L+ L G MV VA E+ E+L D Sbjct 657 HSQGEIAAAYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDR 716 Query 707 ANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIA 766 ++AA+N P +VVVSG AA+ ++ A R R R+ V +A HS+ +E + + T + Sbjct 717 VSIAAINGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVL 776 Query 767 AGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVG 826 AGI R S+VTG D +YW + R+ V+F + V+ G F+E Sbjct 777 AGIEPLSSRTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAVRSACGHGYRTFIESS 836 Query 827 PGGGLTALVEQSLPLGEALS------VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF 880 P L A +E + A S V + RE + L + A F AG +DW Sbjct 837 PHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAAAAFVAGVNVDWRGPL 896 Query 881 GSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTG 940 G +ELPTYAF+++R+WL S D SG+GL A H LLGAVVE P+S VVLTG Sbjct 897 DGAG-LVELPTYAFEKRRFWLSGEGV-SVDASGLGLSAGGHALLGAVVELPESGGVVLTG 954 Query 941 RLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGG-V 999 RL++G WLADH ++GVV+ G FVELA+RA D+V C VV ELT+ TPLVLP G Sbjct 955 RLALGAHGWLADHAVSGVVVFPGTGFVELAIRAVDEVGCSVVNELTLRTPLVLPASGSVA 1014 Query 1000 QLQVVVGVGEMGQRPVSIYSR-----NAESDSGWVLHARGVLGAKAVAPAADLSVWPPLG 1054 VV + +R VSIYSR + ++ S WV HA G LGA + PAADLS WPP G Sbjct 1015 VQVVVGAAADSAERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAG 1074 Query 1055 AAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLV 1114 A VDV Y+R GY YG AF+GLTAMW R ELFA+ +P+ T SGFG+HP + Sbjct 1075 AIAVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAGST-SGFGVHPAL 1133 Query 1115 LDAALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPV 1174 LDAALH + A +LPFSWQGVSLHAAGA+ VR RIAP G +VSVELAD GLPV Sbjct 1134 LDAALHTAVIANPDADLVLPFSWQGVSLHAAGAASVRVRIAPVGPSSVSVELADDLGLPV 1193 Query 1175 LSVQALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWE-LESFQD 1233 LSV+A+V R VS Q + A V+A+ L EV W P+ +A D + ++E + + D Sbjct 1194 LSVKAMVARPVSEQQMRAVVSASGP--DRLFEVVWTPMTVAATDAAPAYELFESIAADGD 1251 Query 1234 GVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQA 1290 + Y TH+ L A+QSWL + +G LVV T+G++ G+D T+LAGAAVWGLVRSAQ Sbjct 1252 PLSGTYQRTHQALAAVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQT 1311 Query 1291 EHPGRVML---VDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSG 1347 E+PGR++L + + V + GE Q+++RNG Y AR+ R + +P + Sbjct 1312 ENPGRLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILVPPVDGP 1371 Query 1348 WRLVAGGAGALEDLTLASCP--AKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGA 1405 WRL AG E+L L P L PGQVR+ +RA+ NFRD+++ LG++ A +G Sbjct 1372 WRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALIGG 1431 Query 1406 EGAGVVTEVGPGVTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVF 1464 EGAGVV E+GP VT AVGD V G +G+ D RL++ P W +AA + VF Sbjct 1432 EGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLVAGDVRLLLPKPADWSYAEAAAISAVF 1491 Query 1465 LTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGC 1524 TAYYA LA VQPG+ VLVHAA GGVGMAAVQLAR GLEV+ATAS+GKWD L MG Sbjct 1492 TTAYYAFVHLANVQPGQRVLVHAATGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGF 1551 Query 1525 DNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFG 1584 D H++DSR+L FEE F T GR VDVVL+SLAGEF DASLRLL GG F+EMGKT+ Sbjct 1552 DEDHISDSRSLEFEEKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIR 1611 Query 1585 TP 1586 P Sbjct 1612 DP 1613 >gi|342860755|ref|ZP_08717405.1| RifB protein [Mycobacterium colombiense CECT 3035] gi|342131779|gb|EGT85036.1| RifB protein [Mycobacterium colombiense CECT 3035] Length=2129 Score = 1711 bits (4432), Expect = 0.0, Method: Compositional matrix adjust. Identities = 968/1607 (61%), Positives = 1136/1607 (71%), Gaps = 26/1607 (1%) Query 1 MSGTTTH-VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELV 59 M+G T V L++ D R +R A +EPVAVVGM CRYPGGV+SPE LW++V Sbjct 1 MNGNTEELVKALRQALKDNERLKRENRQYLAAATEPVAVVGMACRYPGGVNSPEALWQMV 60 Query 60 AQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALA 119 GRD VS+FPADRGW++ GLFD DPDA GK Y R G FL GDFDA FFGI PSEALA Sbjct 61 VDGRDVVSEFPADRGWNLTGLFDADPDAVGKSYARCGGFLSDVGDFDAAFFGIAPSEALA 120 Query 120 MDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGS 177 MDPQQRLLLEVSWEALER GIDP LRGSATGVFAG+ H YGGQ + G LE YGL GS Sbjct 121 MDPQQRLLLEVSWEALERAGIDPATLRGSATGVFAGIFHGSYGGQGRVPGHLERYGLRGS 180 Query 178 TLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPA 237 TLSVASGRVAY LG EGPAVSVDTACSSSLVALHLA QSLRSGECDLALAGGVTVMATPA Sbjct 181 TLSVASGRVAYSLGFEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA 240 Query 238 AFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAV 297 F+EFSRQRALA DGRCK YAGAADGT +SEG GVLV+ERL DARR GHPVLA+VRGSAV Sbjct 241 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLADARRHGHPVLAVVRGSAV 300 Query 298 NQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATY 357 NQDGASNGL PNGPSQQRVIRAALA+ARL +VD+VEGHGTGT LGDPIEAQA+LATY Sbjct 301 NQDGASNGLATPNGPSQQRVIRAALANARLGTADVDLVEGHGTGTTLGDPIEAQAVLATY 360 Query 358 GQDRV--EPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSV 415 GQDR +PLWLGSIKSN+GHTSAAAG GVIK+VQA+RHGVMPKTLHVD PTPHVDWS Sbjct 361 GQDRPTDQPLWLGSIKSNMGHTSAAAGAGGVIKVVQAIRHGVMPKTLHVDEPTPHVDWSA 420 Query 416 GAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVAS-PTAASAV 474 GAVSLLT+ R W RPRRAGVSSFGISGTNAHVI+EQ + PE A+ P V Sbjct 421 GAVSLLTEQRGWPAVERPRRAGVSSFGISGTNAHVIVEQ----YTPEPETATRPGDDVVV 476 Query 475 PWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALL 534 PWVLSARS +ALA QA RLLA V A+P + +DVGWSLV TR+ FEHRAVVVGAD LL Sbjct 477 PWVLSARSGEALANQAARLLARVKADPGVRVLDVGWSLVATRSRFEHRAVVVGADGAQLL 536 Query 535 AGLAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAE 594 GL ALAAGE GAG+ VGRA VGKTVFVFPGQG+QW GMGAQL +FA A+ Sbjct 537 RGLTALAAGEQGAGLVVGRAHPVGKTVFVFPGQGSQWRGMGAQLLDSSRVFAEHMQRCAD 596 Query 595 ELDRHLRLPLRNVLWEGDEAL--LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSV 652 L ++ L +V+ G L + QPAL+A+ V+LA L + G++PD +IGHS Sbjct 597 ALAAYVDWSLIDVI-RGAPGTPGLDRVDVVQPALWAVMVSLAELWRSVGVTPDAVIGHSQ 655 Query 653 GEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAAS---EEEVLPVLVDGANL 709 GEIAAA++AG LSL DAA +VA R RL+ L G MV +A E+++ + N+ Sbjct 656 GEIAAAYVAGALSLDDAARVVALRSRLLVRLAGRGGMVSLACGLPRAEQLIAGWGERLNI 715 Query 710 AAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGI 769 A VN +VVVSG A++++ R R+ V +A HS ++ + G+ Sbjct 716 ATVNGVAAVVVSGEVDALAELMQRCDADNIRARRIDVDYASHSAQVDAIREPLADALHGL 775 Query 770 SVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGG 829 + + S VTG+ D YW + R V+F V+ G F+E P Sbjct 776 APRSSAVAFFSTVTGEPMDTAGLDADYWFQSIRHTVQFERAVRSACDAGYQAFIESSPHP 835 Query 830 GLTALVEQSLPLGE-ALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRI 887 L A +E ++P E A + + R+ + + A G +DW A G GR + Sbjct 836 VLMAAIEDTMPDSERAWVIPSLGRDDGGLDRFWLSAAQAHVFGVAVDWRAAMAGLGGRAV 895 Query 888 ELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQ 947 +LPTY F RQ +WLP SAG+ D++ +GL AA HGLLGAVV +PDS VVLTGRLS Q Sbjct 896 DLPTYGFVRQHFWLPGGSAGTQDVTTLGLAAAEHGLLGAVVPRPDSGGVVLTGRLSTAAQ 955 Query 948 RWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGV 1007 WLADH + VL GA FVELA+RA D+V V++ELT+ PL+LP GGVQ+Q+VVG Sbjct 956 AWLADHAVGETVLFPGAGFVELAIRAGDEVGATVLDELTLSAPLLLPPAGGVQVQLVVGA 1015 Query 1008 -GEMGQRPVSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQR 1066 E G RP+S+YS AE DS W LHA G+L V P ADLS+WPP GA VDV GAY R Sbjct 1016 PDEAGSRPLSVYSAGAEPDSEWTLHAEGLLRPGTVTPGADLSIWPPAGATAVDVTGAYAR 1075 Query 1067 FAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVG 1126 A+ GY+YG AF+GL AMW+R ELFA+V VPDD GFG+HP++LDAALHA+G+ Sbjct 1076 LAQRGYDYGGAFRGLRAMWQRGDELFAEVVVPDDAGTQDGGFGLHPVLLDAALHAIGVAA 1135 Query 1127 EQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVS 1186 EQ T+LPFSWQGVSLHA+GASR R RIAPAG G+VSVELAD GLPVLSV++L MR VS Sbjct 1136 EQDQTLLPFSWQGVSLHASGASRARVRIAPAGAGSVSVELADGTGLPVLSVRSLAMRPVS 1195 Query 1187 SQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL-ESFQDGVGPVYSATHRV 1245 ++ L+AA A A GLL+V W P+ L D A +WEL + D V V++A + Sbjct 1196 AEQLTAAPAQRSRA-EGLLDVTWSPIALGGADSGAGATLWELGDHGGDVVKAVHAAAAEI 1254 Query 1246 LVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHPGRVMLVDSD 1302 L ALQSWL E AG L V T+G+V G++ ++LAGAAVWGLVRSAQAEHPGR++L+DSD Sbjct 1255 LAALQSWLRDENAGVLAVQTRGAVALAGEEVSDLAGAAVWGLVRSAQAEHPGRMVLIDSD 1314 Query 1303 GSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLT 1362 GS+D VI CGE Q+++R GTAYAARL +R P+ LP ++ WRL AGG G L+DL Sbjct 1315 GSLDAAAVIDCGEPQVVVRQGTAYAARLRPVRVGPVAALP--SAAWRLDAGGEGTLQDLV 1372 Query 1363 LASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPGVTGLA 1422 +++CP EL GQVR+ V A+GVNFRDVLVALG+YPG +LGAEG+GVV EVGP VTGLA Sbjct 1373 VSACPRTELTGGQVRVAVAAVGVNFRDVLVALGMYPGGGQLGAEGSGVVVEVGPDVTGLA 1432 Query 1423 VGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGES 1482 VGD VMGLLGV GSEAVVD R+V +P L AAGVPVVFLTA Y L VL ++ GE Sbjct 1433 VGDAVMGLLGVVGSEAVVDHRVVTPVPPGLSLVAAAGVPVVFLTALYGLSVLGGLRAGER 1492 Query 1483 VLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFW 1542 VLVH A GGVGMAAVQLAR WG EVF TAS GKWDTL MG D+ H+ DSRT FE F Sbjct 1493 VLVHTATGGVGMAAVQLARHWGAEVFVTASSGKWDTLRAMGFDDDHIGDSRTTEFETKFG 1552 Query 1543 LTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTPRSL 1589 T G G DVVLNSLAGEFTDASLRLL GGRFIEMGKT+ P ++ Sbjct 1553 SATGGAGFDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPHAV 1599 >gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Mycobacterium marinum M] gi|183176352|gb|ACC41462.1| polyketide synthase, Pks12 [Mycobacterium marinum M] Length=4187 Score = 1709 bits (4426), Expect = 0.0, Method: Compositional matrix adjust. Identities = 943/1598 (60%), Positives = 1149/1598 (72%), Gaps = 55/1598 (3%) Query 34 EPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYT 93 +P+A+VGM CRYPGG++SP+ LW+++ RD +SDFPADRGWD+ GLF+PDPD G YT Sbjct 2071 DPIAIVGMSCRYPGGIESPDDLWDMLMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYT 2130 Query 94 RRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLEVSWEALERTGIDPTKLRGSATGVF 153 R G F++ GDFD FFG+GPSEALAMDPQQR+ LE+SWEALER GI+P LRGSATGVF Sbjct 2131 RTGGFVDRVGDFDPAFFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVF 2190 Query 154 AGVIHAGYGGQLSGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLA 213 AGV+ GYG + +EG+ LTG SVASGRVAYVLGLEGPAVSVDTACSSSLVALH+A Sbjct 2191 AGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMA 2250 Query 214 VQSLRSGECDLALAGGVTVMATPAAFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGVL 273 VQSLRSGECDLALAGGVT+ ATP FVEFSR R L+ DGRCK +AGAADGT +SEG G+L Sbjct 2251 VQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFAGAADGTGFSEGGGML 2310 Query 274 VVERLVDARRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVIRAALASARLRAVEVD 333 VVERL DA+RLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRV+RAALA+A L A EVD Sbjct 2311 VVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVD 2370 Query 334 VVEGHGTGTMLGDPIEAQALLATYGQDR------VEPLWLGSIKSNIGHTSAAAGVAGVI 387 VVEGHGTGT LGDPIEAQALLATYGQDR + LWLGSIKSN+GHT AAAGVAGVI Sbjct 2371 VVEGHGTGTTLGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI 2430 Query 388 KMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAW---SVHGRPRRAGVSSFGIS 444 KMVQAMRH V+P TLHVDVP+PHVDWS GAV LLT+ + W S R RRAGVSSFGIS Sbjct 2431 KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGIS 2490 Query 445 GTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQALAGQAQRLLAFVAANPDLD 504 GTNAHVI+E AP VE +S A VPWV+SA+S AL QA RL A V ++ +LD Sbjct 2491 GTNAHVIVEAAPRVEV---GGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVRSHDELD 2547 Query 505 PIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE-SGAGVAVGRARSVGKTVFV 563 DVGWSL R+ FEHRAVV+G DR LLAGL LA E GA V G A + GKTVFV Sbjct 2548 VADVGWSLAG-RSTFEHRAVVLGVDRDGLLAGLDELAGDEFGGASVIRGVAGAAGKTVFV 2606 Query 564 FPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQ 623 FPGQG+Q +GMG L+A P+FA AF+ V ELDRHL PLR V+W DE LL +TEFAQ Sbjct 2607 FPGQGSQLLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVIWGHDENLLNTTEFAQ 2666 Query 624 PALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAEL 683 PALFA+EVAL LL+ WG+ PDF++GHSVGE++AAH+AGVLSL +AA LVAARGRLM L Sbjct 2667 PALFAVEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGRLMQAL 2726 Query 684 PAGGVMVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHR 743 P GG M+ V A+E+EVLP+L ++AA+N P SVV+SG + AVS +A+ GRRVHR Sbjct 2727 PDGGAMIAVQATEQEVLPLLGAQVSIAAINGPASVVISGAQDAVSAVAEQLRADGRRVHR 2786 Query 744 LAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARR 803 LAVSHAFHS LM+PM+ EF +A ++V+ P I ++SN+TGQ+AG +G YW H R Sbjct 2787 LAVSHAFHSPLMDPMIDEFATVAGELTVNAPTIGIISNLTGQLAGEDFGSAAYWKRHVRD 2846 Query 804 PVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSLP----LGEALSVAMMRREHPEVSS 859 VRFA+ ++ + GA RF+EVGP GLTA +E+ L + + +R++ PE S Sbjct 2847 AVRFADSIRFAQSAGAARFLEVGPSSGLTASIEEVLSDAAVTNPVATASALRKDRPEPVS 2906 Query 860 VLGAVATLFTAGAQMDWPAVFGSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAA 919 ++ AVA +F AG +DW AV G +ELPTYAF+R+R+WL A +AD +G+GL A Sbjct 2907 LVSAVAGVFVAGTAVDWRAVVGQ-SNFVELPTYAFERRRFWL-SGDAVAADAAGLGLQAG 2964 Query 920 RHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDC 979 H LLGAVVE P S VVLTGRLS+ Q WLADH + GVV+ GA FVELA+RA D+V C Sbjct 2965 EHALLGAVVELPASGGVVLTGRLSLAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGC 3024 Query 980 GVVEELTVVTPLVLPTVGGVQLQVVVGV-GEMGQRPVSIYSRNAESDSGWVLHARGVLGA 1038 VV+ELT+ PLVLP+ G V +QVVVG + G R VS+YSR ++ S WVLHA G LG+ Sbjct 3025 RVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVSVYSRG-DAGSDWVLHAEGSLGS 3083 Query 1039 KAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVP 1098 + PA DLS WPP+GA V+ YQ+ AE GY YG AF+GL AMWRR E+FA+VA+P Sbjct 3084 GSPEPATDLSTWPPVGAVEVENADGYQQLAERGYGYGPAFRGLNAMWRRGDEVFAEVALP 3143 Query 1099 DDVDVTLSGFGIHPLVLDAALHAMGMVGE--------QAATMLPFSWQGVSLHAAGASRV 1150 D V++SGFGIHP++LDAALHA+ + + + + ++PF+WQGV+LHAAGAS V Sbjct 3144 ADAGVSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHAAGASAV 3203 Query 1151 RARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLSAAVAAA--------DAAGR 1202 RARIAPAG VS+EL+D GLPVLSV +++ R V+ Q L AAV+ A D + Sbjct 3204 RARIAPAGPSAVSIELSDGLGLPVLSVASMLARPVTDQQLRAAVSGAGPDRLFGVDWTAQ 3263 Query 1203 GLLEVAWLPVEL-------AHNDISADLVVWELESFQDGVGPVYSATHRVLVALQSWLAQ 1255 E+ +PV + +D A +V + + V VY+AT VL L+SWL++ Sbjct 3264 PSAELQPVPVRIWGAVESEGDDDPGASVVFESVPQAGEVVAGVYAATAAVLEVLRSWLSR 3323 Query 1256 ERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLVDSDGSMD---VGD 1309 + AG+LV+ T+G+V +D T+LAG+AVWGLVRSAQ EHPGR++LVD+D +D V Sbjct 3324 DGAGQLVITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPGRIVLVDTDAQLDEHAVAA 3383 Query 1310 VIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRLVAGGAGALEDLTLASCPAK 1369 V+ GE Q++ RNG Y AR+ R L +P + WRL AG E+L L P Sbjct 3384 VLAAGEPQVLWRNGEVYTARVHGSRAVAGLLVPPGDGPWRLGMSTAGTFENLRLEPIPDA 3443 Query 1370 E--LAPGQVRIEVRALGVNFRDVLVALGIYPGA-AELGAEGAGVVTEVGPGVTGLAVGDP 1426 + L PG VR+ + A+ NFRDV++ALG+YP A +G EGAGVV E AVGD Sbjct 3444 DAALQPGHVRVALSAMAANFRDVMIALGLYPDPDAAMGVEGAGVVVETASTDGRFAVGDR 3503 Query 1427 VMGLLGV-AGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQVQPGESVLV 1485 V+GL G+ A+ D RL+VK+P W T AA VVF TA+YALR LA VQPG+ +LV Sbjct 3504 VVGLFPEGTGTIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV 3563 Query 1486 HAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAFEETFWLTT 1545 HAA GGVGMAAVQLAR WGLEVFATAS+GKWDTL MG D H+ DSR+L FE+ F T Sbjct 3564 HAATGGVGMAAVQLARHWGLEVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAAT 3623 Query 1546 EGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 GRG+DVVL+SLAGEF DASLRL+ GG F+EMGKT+ Sbjct 3624 GGRGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDI 3661 Score = 1527 bits (3954), Expect = 0.0, Method: Compositional matrix adjust. Identities = 892/1619 (56%), Positives = 1075/1619 (67%), Gaps = 51/1619 (3%) Query 8 VDYLKRLTADLR-------RTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVA 60 VD L+ T LR R +R L + SEP+A+VGM CR+PGGVDSPE LW++VA Sbjct 2 VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVA 61 Query 61 QGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAM 120 +GRD +SDFP DRGWD+ LFDPDPD K Y G F++ DFD GFFGI PSEALAM Sbjct 62 EGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGFVDGVADFDPGFFGIAPSEALAM 121 Query 121 DPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQLSGELEGYGLTGSTLS 180 DPQ R+LLE+SWEALER+GIDPT LRGSATGVFAG+I GYG + E+EGY LTG T S Sbjct 122 DPQHRMLLELSWEALERSGIDPTGLRGSATGVFAGLIVQGYG-MFAEEIEGYRLTGMTSS 180 Query 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFV 240 VASGRVAYVLGLEGPAVSVDTACSSSLVALH+AVQSLRSGECDLALAGG TV ATP FV Sbjct 181 VASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFV 240 Query 241 EFSRQRALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQD 300 EFSR R LA DGR K YAGAADG WSEG +LVVERL DA+RLGHPVLALVRGSAVNQD Sbjct 241 EFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVRGSAVNQD 300 Query 301 GASNGLTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQD 360 GASNGLTAPNGPSQQRV+RAALA+A L A EVDVVEGHGTGT LGDPIEAQALLATYGQD Sbjct 301 GASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYGQD 360 Query 361 R------VEPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWS 414 R + LWLGSIKSN+GHT AAAGVAGVIKMVQAMRH V+P TLHVDVP+PHVDWS Sbjct 361 RGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWS 420 Query 415 VGAVSLLTQPRAW---SVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAA 471 GAV LLT+ + W S R RRAGVSSFGISGTNAHVI+E AP VE +S A Sbjct 421 AGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAHVIVEAAPRVEV---GGSSGGAV 477 Query 472 SAVPWVLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRG 531 VPWV+SA+S AL QA RL A V ++ +LD DVGWSL R+ FEHRAVV+G DR Sbjct 478 PVVPWVVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGVDRD 536 Query 532 ALLAGLAALAAGE-SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFD 590 LLAGL LA E GA V G A + GKTVFVFPGQG+QW+GMG +L P+FA + Sbjct 537 GLLAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTAPVFARHIE 596 Query 591 AVAEELDRHLRLPLRNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIG 649 + + + L +VL A L + QP LFA+ V+LA L + G+ PD +IG Sbjct 597 SCGQAFAEFVDWSLLDVLRGAAGAPGLDRVDVVQPVLFAVMVSLAELWKSVGVRPDAVIG 656 Query 650 HSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEE---EVLPVLVDG 706 HS GEIAAA++AG LSL DAA +V R +L+ L G MV VA E+ E+L D Sbjct 657 HSQGEIAAAYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDR 716 Query 707 ANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIA 766 ++AA+N P +VVVSG AA+ ++ A R R R+ V +A HS+ +E + + T + Sbjct 717 VSIAAINGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVL 776 Query 767 AGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVG 826 AGI R S+VTG D +YW + R+ V+F + V+ G F+E Sbjct 777 AGIEPLSSRTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAVRSACGHGYRTFIESS 836 Query 827 PGGGLTALVEQSLPLGEALS------VAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF 880 P L A +E + A S V + RE + L + A F AG +DW Sbjct 837 PHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAAAAFVAGVNVDWRGPL 896 Query 881 GSPGRRIELPTYAFQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTG 940 G +ELPTYAF+++R+WL S D SG+GL A H LLGAVVE P+S VVLTG Sbjct 897 DGAG-LVELPTYAFEKRRFWLSGEGV-SVDASGLGLSAGGHALLGAVVELPESGGVVLTG 954 Query 941 RLSVGEQRWLADHVIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGG-V 999 RL++G WLADH ++GVV+ G FVELA+RA D+V C VV ELT+ TPLVLP G Sbjct 955 RLALGAHGWLADHAVSGVVVFPGTGFVELAIRAGDEVGCSVVNELTLRTPLVLPASGSVA 1014 Query 1000 QLQVVVGVGEMGQRPVSIYSRNAESDSG--WVLHARGVLGAKAVAPAADLSVWPPLGAAP 1057 VV + +R VSIYSR ++D+G WV HA G LGA + PAADLS WPP GA Sbjct 1015 VQVVVGAAADSAERSVSIYSRT-DTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAIA 1073 Query 1058 VDVDGAYQRFAELGYEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDA 1117 VDV Y+R GY YG AF+GLTAMW R ELFA+V +P+ T SGFG+HP +LDA Sbjct 1074 VDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEVRLPEAAGST-SGFGVHPALLDA 1132 Query 1118 ALHAMGMVGEQAATMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSV 1177 ALH + A +LPFSWQGVSLHAAGA+ VR RIAP G +VSVELAD GLPVLSV Sbjct 1133 ALHTAVIANPDAELVLPFSWQGVSLHAAGAASVRVRIAPVGPSSVSVELADDLGLPVLSV 1192 Query 1178 QALVMRSVSSQLLSAAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWELESFQ-DGVG 1236 +A+V R VS Q + A V+A+ L EV W P+ +A D + ++E + + D + Sbjct 1193 KAMVARPVSEQQMRAVVSASGP--DRLFEVVWTPMTVAATDAAPAYELFESVAAEGDPLS 1250 Query 1237 PVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVWGLVRSAQAEHP 1293 Y TH+ L A+QSWL + +G LVV T+G++ G+D T+LAGAAVWGLVRSAQ E+P Sbjct 1251 GTYQRTHQALAAVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENP 1310 Query 1294 GRVML---VDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSGWRL 1350 GR++L + + V + GE Q+++RNG Y AR+ R + +P + WRL Sbjct 1311 GRLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILVPPVDGPWRL 1370 Query 1351 VAGGAGALEDLTLASCP--AKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGA 1408 AG E+L L P L PGQVR+ +RA+ NFRD+++ LG++ A +G EGA Sbjct 1371 GLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALIGGEGA 1430 Query 1409 GVVTEVGPGVTGLAVGDPVMGLL-GVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTA 1467 GVV E+GP VT AVGD V G +G+ D RL++ P W +AA + VF TA Sbjct 1431 GVVVEIGPEVTEFAVGDAVYGFFPDGSGTLVAGDVRLLLPKPADWSYAEAAAISAVFTTA 1490 Query 1468 YYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNT 1527 YYA LA VQPG+ VLVHAA GGVGMAAVQLAR GLEV+ATAS+GKWD L MG D Sbjct 1491 YYAFVHLANVQPGQRVLVHAATGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDED 1550 Query 1528 HVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEFGTP 1586 H++DSR+L FEE F T GRGVDVVL+SLAGEF DASLRLL GG F+EMGKT+ P Sbjct 1551 HISDSRSLEFEEKFREVTGGRGVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDP 1609 >gi|289745901|ref|ZP_06505279.1| polyketide synthase pks7 [Mycobacterium tuberculosis 02_1987] gi|294996612|ref|ZP_06802303.1| polyketide synthase pks7 [Mycobacterium tuberculosis 210] gi|289686429|gb|EFD53917.1| polyketide synthase pks7 [Mycobacterium tuberculosis 02_1987] gi|326903275|gb|EGE50208.1| polyketide synthase pks7 [Mycobacterium tuberculosis W-148] gi|339294619|gb|AEJ46730.1| polyketide synthase pks7 [Mycobacterium tuberculosis CCDC5079] gi|339298252|gb|AEJ50362.1| polyketide synthase pks7 [Mycobacterium tuberculosis CCDC5180] Length=2126 Score = 1701 bits (4404), Expect = 0.0, Method: Compositional matrix adjust. Identities = 993/1606 (62%), Positives = 1148/1606 (72%), Gaps = 40/1606 (2%) Query 8 VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVS 67 V L+R R +R DL A+ +EPVAVVGMGCRYPGGVDSPETLWELVA GRDAVS Sbjct 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 Query 68 DFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLL 127 +FPADRGWDV GLFDPDPDA GK YTR G FL FDA FFGI PSEALAMDPQQRLL Sbjct 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 Query 128 LEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGSTLSVASGR 185 LEVSWEALER GIDP LRGS TGVFAGV H YGGQ + G+LE YGL GSTLSVASGR Sbjct 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 Query 186 VAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 245 VAYVLGL+GPAVSVDTACSSSLVALHLAVQSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 Query 246 RALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNG 305 RAL+ DGRCK YAGAADGTA++EGAGVLV+ RL DARRLGHPVLALVRGSAVNQDGASNG Sbjct 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 Query 306 LTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRVE-P 364 L PNGP+QQRVI AALASARL +VDVVEGHGTGT LGDPIEAQA+LATYGQ + P Sbjct 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRP 368 Query 365 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQP 424 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+PKTLHVDVPTPHVDWS GAVSLLT+P Sbjct 369 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEP 428 Query 425 RAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQ 484 R W V GRPRRAGVSSFGISGTNAHVILE+AP VE V A AVPWVLSARS Q Sbjct 429 RPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPV--GAAHGNDPVAVPWVLSARSAQ 486 Query 485 ALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE 544 AL QA+RLLA+V A+ ++ P+DVGWSLV TR++F+HRAVVVGADR L+ GL LAAG Sbjct 487 ALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGV 546 Query 545 SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPL 604 GA V GRA++VGKT FVFPGQGAQW+GMGAQL A P+FA L H+ L Sbjct 547 PGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSL 606 Query 605 RNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGV 663 +VL A L + QPAL+A+ V+LA L + G+ PD +IGHS GEIAAA++AG Sbjct 607 LDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGA 666 Query 664 LSLTDAAGLVAARGRLMAELPAGGVMVVVAASE---EEVLPVLVDGANLAAVNAPHSVVV 720 LSL DAA +VA R RL+ L G MV +A + E++ D N+AAVN SVV+ Sbjct 667 LSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVL 726 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 +G AV+++ G R R+ V +A HS ++ + E GI + S Sbjct 727 AGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFS 786 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSL- 839 VTG++ + +YW R+PV+FA V+ G FVE P L A +E++L Sbjct 787 TVTGELMDTAGVNAEYWYRSIRQPVQFARAVRNAFDGGYRVFVESSPHPVLIAGIEETLV 846 Query 840 -----PLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGS-PGRRIELPTYA 893 GE + + + R+ V + AG +DW A F GRR+ELPTYA Sbjct 847 DCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYA 906 Query 894 FQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADH 953 F RQR+WL A D+ GVGL+ A HGLL AVV++PDS VVLTGR+SV WLADH Sbjct 907 FARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADH 966 Query 954 VIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQR 1013 + VVL G FVELALRA D+V C V++ELT+ PLVLP G VV GV + G R Sbjct 967 AVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTR 1026 Query 1014 PVSIYSRNAESDS--GWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELG 1071 V +YS ++DS GW LHA+GVLG +V PAA+LSVWPP+GA +DV YQ A G Sbjct 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 Query 1072 YEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAAT 1131 Y YG AF+GL A+WRR +E+FADV +P+ V + GFGIHP VLDAALHA G+V + T Sbjct 1087 YGYGPAFRGLQALWRRGAEVFADVTLPEGVPI--RGFGIHPAVLDAALHAWGIVEGEQQT 1144 Query 1132 MLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLS 1191 MLPFSWQGV LHA+GA+RVR R+AP G G VSVELAD GLPVLSV+ L++R VS+ Sbjct 1145 MLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA---- 1200 Query 1192 AAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL------ESFQDGVGPVYSATHRV 1245 AA++ + A RGLLE+ W PV L DI D VVWEL ++ D + VY H V Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLVDSD 1302 L LQSWLA + G VV+T+G+VG D T+LAGAAVWGLVRSAQAEHPGRV+LVD+D Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1303 GSMDVGDVIG----CGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSG-WRLVAGGAGA 1357 GS+ V D +G GE QL++R G YAARLA + L LP ++G WRLVAGG G Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGWRLVAGGGGT 1378 Query 1358 LEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 L D+ +A ELA GQVR+ V A+GVNFRDVLVALG+YPG ELG +GAGVV EVGPG Sbjct 1379 LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 Query 1418 VTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQV 1477 VTGLAVGD VMGLLG+ GSEAVVDARLV +P W L +AA VPV FLTA+Y L VLA+V Sbjct 1439 VTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEV 1498 Query 1478 QPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAF 1537 G+ VLVHA GGVGMAAV LAR WG EVF TASR KWDTL MG D+ H++DSR+L F Sbjct 1499 AAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEF 1558 Query 1538 EETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 EE F TEG GVDVVLNSLAGEFTDASLRLLP GGRFIE+GKT+ Sbjct 1559 EEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDI 1604 >gi|340626667|ref|YP_004745119.1| putative polyketide synthase PKS7 [Mycobacterium canettii CIPT 140010059] gi|340004857|emb|CCC44002.1| putative polyketide synthase PKS7 [Mycobacterium canettii CIPT 140010059] Length=2126 Score = 1699 bits (4401), Expect = 0.0, Method: Compositional matrix adjust. Identities = 992/1606 (62%), Positives = 1147/1606 (72%), Gaps = 40/1606 (2%) Query 8 VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVS 67 V L+R R +R DL A+ +EPVAVVGMGCRYPGGVDSPETLWELVA GRDAVS Sbjct 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 Query 68 DFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLL 127 +FPADRGWDV GLFDPDPDA GK YTR G FL FDA FFGI PSEALAMDPQQRLL Sbjct 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 Query 128 LEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGSTLSVASGR 185 LEVSWEALER GIDP LRGS TGVFAGV H YGGQ + G+LE YGL GSTLSVASGR Sbjct 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 Query 186 VAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 245 VAYVLGL+GPAVSVDTACSSSLVALHLAVQSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 Query 246 RALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNG 305 RAL+ DGRCK YAGAADGTA++EGAGVLV+ RL DARRLGHPVLALVRGSAVNQDGASNG Sbjct 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 Query 306 LTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRVE-P 364 L PNGP+QQRVI AALASARL +VDVVEGHGTGT LGDPIEAQA+LATYGQ + P Sbjct 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRP 368 Query 365 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQP 424 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+PKTLHVDVPTPHVDWS GAVSLLT+P Sbjct 369 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEP 428 Query 425 RAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQ 484 R W V GRPRRAGVSSFGISGTNAHVILEQAP VE V A AVPWVLSARS Q Sbjct 429 RPWHVPGRPRRAGVSSFGISGTNAHVILEQAPAVEPV--GAAHGNDPVAVPWVLSARSAQ 486 Query 485 ALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE 544 AL QA+RLLA+V A+ ++ P+DVGWSLV TR++F+HRAVVVGADR L+ GL LAAG Sbjct 487 ALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGV 546 Query 545 SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPL 604 GA V GRA++VGKT FVFPGQGAQW+GMGAQL A P+FA L H+ L Sbjct 547 PGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSL 606 Query 605 RNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGV 663 +VL A L + QPAL+A+ V+LA L + G+ PD +IGHS GEIAAA++AG Sbjct 607 LDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGA 666 Query 664 LSLTDAAGLVAARGRLMAELPAGGVMVVVAASE---EEVLPVLVDGANLAAVNAPHSVVV 720 LSL DAA +VA R RL+ L G MV +A + E++ D N+AAVN SVV+ Sbjct 667 LSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVL 726 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 +G AV+++ G R R+ V +A HS ++ + E GI + S Sbjct 727 AGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFS 786 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSL- 839 VTG++ + +YW R+PV+F V+ G FVE P L A +E++L Sbjct 787 TVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLV 846 Query 840 -----PLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGS-PGRRIELPTYA 893 GE + + + R+ V + AG +DW A F GRR+ELPTY Sbjct 847 DCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYG 906 Query 894 FQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADH 953 F RQR+WL A D+ GVGL+ A HGLL AVV++PDS VVLTGR+SV WLADH Sbjct 907 FARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADH 966 Query 954 VIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQR 1013 + VVL G FVELALRA D+V C V++ELT+ PLVLP G VV GV + G R Sbjct 967 AVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPAGGVRVQVVVGGVEQSGTR 1026 Query 1014 PVSIYSRNAESDS--GWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELG 1071 V +YS ++DS GW LHA+GVLG +V PAA+LSVWPP+GA +DV YQ A G Sbjct 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 Query 1072 YEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAAT 1131 Y YG AF+GL A+WRR +E+FADV +P+ V + GFGIHP VLDAALHA G+V + T Sbjct 1087 YGYGPAFRGLQALWRRGAEVFADVTLPEGVPI--RGFGIHPAVLDAALHAWGIVEGEQQT 1144 Query 1132 MLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLS 1191 MLPFSW+GV LHA+GA+RVR R+AP G G VSVELAD GLPVLSV+ L++R VS+ Sbjct 1145 MLPFSWEGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA---- 1200 Query 1192 AAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL------ESFQDGVGPVYSATHRV 1245 AA++ + A RGLLE+ W PV L DI D VVWEL ++ D + VY H V Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLVDSD 1302 L LQSWLA + G VV+T+G+VG D T+LAGAAVWGLVRSAQAEHPGRV+LVD+D Sbjct 1261 LEVLQSWLASDVTGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1303 GSMDVGDVIG----CGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSG-WRLVAGGAGA 1357 GS+ V D +G GE QL++R G YAARLA + L LP ++G WRLVAGG G Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGWRLVAGGGGT 1378 Query 1358 LEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 L D+ +A ELA GQVR+ V A+GVNFRDVLVALG+YPG ELG +GAGVV EVGPG Sbjct 1379 LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 Query 1418 VTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQV 1477 VTGLAVGD VMGLLG+ GSEAVVDARLV +P W L +AA VPV FLTA+Y L VLA+V Sbjct 1439 VTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEV 1498 Query 1478 QPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAF 1537 G+ VLVHA GGVGMAAV LAR WG EVF TASR KWDTL MG D+ H++DSR+L F Sbjct 1499 AAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEF 1558 Query 1538 EETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 EE F TEG GVDVVLNSLAGEFTDASLRLLPRGGRFIE+GKT+ Sbjct 1559 EEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPRGGRFIELGKTDI 1604 >gi|254231859|ref|ZP_04925186.1| polyketide synthase pks7 [Mycobacterium tuberculosis C] gi|124600918|gb|EAY59928.1| polyketide synthase pks7 [Mycobacterium tuberculosis C] Length=2126 Score = 1699 bits (4399), Expect = 0.0, Method: Compositional matrix adjust. Identities = 992/1606 (62%), Positives = 1147/1606 (72%), Gaps = 40/1606 (2%) Query 8 VDYLKRLTADLRRTRRRLSDLEAKLSEPVAVVGMGCRYPGGVDSPETLWELVAQGRDAVS 67 V L+R R +R DL A+ +EPVAVVGMGCRYPGGVDSPETLWELVA GRDAVS Sbjct 9 VKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVS 68 Query 68 DFPADRGWDVDGLFDPDPDACGKMYTRRGTFLEHAGDFDAGFFGIGPSEALAMDPQQRLL 127 +FPADRGWDV GLFDPDPDA GK YTR G FL FDA FFGI PSEALAMDPQQRLL Sbjct 69 EFPADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLL 128 Query 128 LEVSWEALERTGIDPTKLRGSATGVFAGVIHAGYGGQ--LSGELEGYGLTGSTLSVASGR 185 LEVSWEALER GIDP LRGS TGVFAGV H YGGQ + G+LE YGL GSTLSVASGR Sbjct 129 LEVSWEALERAGIDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGR 188 Query 186 VAYVLGLEGPAVSVDTACSSSLVALHLAVQSLRSGECDLALAGGVTVMATPAAFVEFSRQ 245 VAYVLGL+GPAVSVDTACSSSLVALHLAVQSLR GECDLAL GGVTVMATPA F+EFSRQ Sbjct 189 VAYVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQ 248 Query 246 RALARDGRCKVYAGAADGTAWSEGAGVLVVERLVDARRLGHPVLALVRGSAVNQDGASNG 305 RAL+ DGRCK YAGAADGTA++EGAGVLV+ RL DARRLGHPVLALVRGSAVNQDGASNG Sbjct 249 RALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHPVLALVRGSAVNQDGASNG 308 Query 306 LTAPNGPSQQRVIRAALASARLRAVEVDVVEGHGTGTMLGDPIEAQALLATYGQDRVE-P 364 L PNGP+QQRVI AALASARL +VDVVEGHGTGT LGDPIEAQA+LATYGQ + P Sbjct 309 LATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDPIEAQAILATYGQRPADRP 368 Query 365 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQP 424 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGV+PKTLHVDVPTPHVDWS GAVSLLT+P Sbjct 369 LWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEP 428 Query 425 RAWSVHGRPRRAGVSSFGISGTNAHVILEQAPVVESVVPEVASPTAASAVPWVLSARSEQ 484 R W V GRPRRAGVSSFGISGTNAHVILE+AP VE V A AVPWVLSARS Q Sbjct 429 RPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPV--GAAHGNDPVAVPWVLSARSAQ 486 Query 485 ALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGE 544 AL QA+RLLA+V A+ ++ P+DVGWSLV TR++F+HRAVVVGADR L+ GL LAAG Sbjct 487 ALTNQARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGV 546 Query 545 SGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPL 604 GA V GRA++VGKT FVFPGQGAQW+GMGAQL A P+FA L H+ L Sbjct 547 PGADVVAGRAQTVGKTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSL 606 Query 605 RNVLWEGDEAL-LTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGV 663 +VL A L + QPAL+A+ V+LA L + G+ PD +IGHS GEIAAA++AG Sbjct 607 LDVLRGAPGAPGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGA 666 Query 664 LSLTDAAGLVAARGRLMAELPAGGVMVVVAASE---EEVLPVLVDGANLAAVNAPHSVVV 720 LSL DAA +VA R RL+ L G MV +A + E++ D N+AAVN SVV+ Sbjct 667 LSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDRLNIAAVNGVSSVVL 726 Query 721 SGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRIPLVS 780 +G AV+++ G R R+ V +A HS ++ + E GI + S Sbjct 727 AGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIAALRGIEPRTSTVAFFS 786 Query 781 NVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVEQSL- 839 VTG++ + +YW R+PV+F V+ G FVE P L A +E++L Sbjct 787 TVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAGIEETLV 846 Query 840 -----PLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVFGS-PGRRIELPTYA 893 GE + + + R+ V + AG +DW A F GRR+ELPTYA Sbjct 847 DCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYA 906 Query 894 FQRQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADH 953 F RQR+WL A D+ GVGL+ A HGLL AVV++PDS VVLTGR+SV WLADH Sbjct 907 FARQRFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADH 966 Query 954 VIAGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVLPTVGGVQLQVVVGVGEMGQR 1013 + VVL G FVELALRA D+V C V++ELT+ PLVLP G VV GV + G R Sbjct 967 AVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTR 1026 Query 1014 PVSIYSRNAESDS--GWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELG 1071 V +YS ++DS GW LHA+GVLG +V PAA+LSVWPP+GA +DV YQ A G Sbjct 1027 NVWVYSAAGQADSSPGWTLHAQGVLGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARG 1086 Query 1072 YEYGRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAAT 1131 Y YG AF+GL A+WRR +E+FADV +P+ V + GFGIHP VLDAALHA G+V + T Sbjct 1087 YGYGPAFRGLQALWRRGAEVFADVTLPEGVPI--RGFGIHPAVLDAALHAWGIVEGEQQT 1144 Query 1132 MLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSSQLLS 1191 MLPFSWQGV LHA+GA+RVR R+AP G G VSVELAD GLPVLSV+ L++R VS+ Sbjct 1145 MLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSVRQLMVRPVSA---- 1200 Query 1192 AAVAAADAAGRGLLEVAWLPVELAHNDISADLVVWEL------ESFQDGVGPVYSATHRV 1245 AA++ + A RGLLE+ W PV L DI D VVWEL ++ D + VY H V Sbjct 1201 AALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV 1260 Query 1246 LVALQSWLAQERAGRLVVLTQGSVG---QDATNLAGAAVWGLVRSAQAEHPGRVMLVDSD 1302 L LQSWLA + G VV+T+G+VG D T+LAGAAVWGLVRSAQAEHPGRV+LVD+D Sbjct 1261 LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTD 1320 Query 1303 GSMDVGDVIG----CGEEQLMIRNGTAYAARLAQLRPQPILQLPDTNSG-WRLVAGGAGA 1357 GS+ V D +G GE QL++R G YAARLA + L LP ++G WRLVAGG G Sbjct 1321 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGGWRLVAGGGGT 1378 Query 1358 LEDLTLASCPAKELAPGQVRIEVRALGVNFRDVLVALGIYPGAAELGAEGAGVVTEVGPG 1417 L D+ +A ELA GQVR+ V A+GVNFRDVLVALG+YPG ELG +GAGVV EVGPG Sbjct 1379 LADVVVAPVAPVELATGQVRVAVGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPG 1438 Query 1418 VTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAAGVPVVFLTAYYALRVLAQV 1477 VTGLAVGD VMGLLG+ GSEAVVDARLV +P W L +AA VPV FLTA+Y L VLA+V Sbjct 1439 VTGLAVGDRVMGLLGLVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEV 1498 Query 1478 QPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDTLHTMGCDNTHVADSRTLAF 1537 G+ VLVHA GGVGMAAV LAR WG EVF TASR KWDTL MG D+ H++DSR+L F Sbjct 1499 AAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTLRAMGFDDIHISDSRSLEF 1558 Query 1538 EETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEMGKTEF 1583 EE F TEG GVDVVLNSLAGEFTDASLRLLP GGRFIE+GKT+ Sbjct 1559 EEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDI 1604 Lambda K H 0.319 0.135 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 4162296874368 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40