BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1664 Length=1017 Score E Sequences producing significant alignments: (Bits) Value gi|289443122|ref|ZP_06432866.1| polyketide synthase pks9 [Mycoba... 2005 0.0 gi|15608802|ref|NP_216180.1| polyketide synthase pks9 [Mycobacte... 2005 0.0 gi|31792851|ref|NP_855344.1| polyketide synthase pks9 [Mycobacte... 2003 0.0 gi|254231860|ref|ZP_04925187.1| polyketide synthase pks9 [Mycoba... 2003 0.0 gi|289447277|ref|ZP_06437021.1| polyketide synthase pks9 [Mycoba... 2002 0.0 gi|340626669|ref|YP_004745121.1| putative polyketide synthase pk... 1998 0.0 gi|308231899|ref|ZP_07414188.2| polyketide synthase pks9 [Mycoba... 1889 0.0 gi|289569711|ref|ZP_06449938.1| polyketide synthase pks9 [Mycoba... 1493 0.0 gi|289761817|ref|ZP_06521195.1| polyketide synthase pks9 [Mycoba... 1448 0.0 gi|308370786|ref|ZP_07422723.2| polyketide synthase pks9 [Mycoba... 1313 0.0 gi|289757775|ref|ZP_06517153.1| polyketide synthase pks9 [Mycoba... 1227 0.0 gi|183982487|ref|YP_001850778.1| polyketide synthase Pks9 [Mycob... 1186 0.0 gi|254820899|ref|ZP_05225900.1| polyketide synthase [Mycobacteri... 1183 0.0 gi|118464601|ref|YP_882291.1| polyketide synthase [Mycobacterium... 1183 0.0 gi|240170123|ref|ZP_04748782.1| polyketide synthase Pks9 [Mycoba... 1175 0.0 gi|118617289|ref|YP_905621.1| polyketide synthase Pks9 [Mycobact... 1167 0.0 gi|342860753|ref|ZP_08717403.1| polyketide synthase [Mycobacteri... 1130 0.0 gi|336457823|gb|EGO36817.1| polyketide synthase family protein [... 916 0.0 gi|41407469|ref|NP_960305.1| Pks8 [Mycobacterium avium subsp. pa... 911 0.0 gi|308376786|ref|ZP_07440032.2| putative acyl transferase domain... 882 0.0 gi|289757774|ref|ZP_06517152.1| polyketide synthase pks9 [Mycoba... 845 0.0 gi|345011383|ref|YP_004813737.1| beta-ketoacyl synthase [Strepto... 822 0.0 gi|289568319|ref|ZP_06448546.1| membrane bound polyketide syntha... 817 0.0 gi|15839791|ref|NP_334828.1| polyketide synthase [Mycobacterium ... 817 0.0 gi|148821601|ref|YP_001286355.1| membrane bound polyketide synth... 817 0.0 gi|289744101|ref|ZP_06503479.1| membrane bound polyketide syntha... 817 0.0 gi|15607546|ref|NP_214919.1| membrane bound polyketide synthase ... 817 0.0 gi|289572990|ref|ZP_06453217.1| membrane bound polyketide syntha... 816 0.0 gi|289441784|ref|ZP_06431528.1| membrane bound polyketide syntha... 816 0.0 gi|344218221|gb|AEM98851.1| membrane bound polyketide synthase [... 816 0.0 gi|254363369|ref|ZP_04979415.1| membrane bound polyketide syntha... 815 0.0 gi|289445944|ref|ZP_06435688.1| membrane bound polyketide syntha... 814 0.0 gi|340625431|ref|YP_004743883.1| polyketide synthase pks6 [Mycob... 814 0.0 gi|302542518|ref|ZP_07294860.1| modular polyketide synthase [Str... 811 0.0 gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Myco... 803 0.0 gi|157884996|gb|ABV91286.1| type I modular polyketide synthase [... 802 0.0 gi|115338567|gb|ABI94379.1| tautomycetin biosynthetic PKS [Strep... 801 0.0 gi|73537113|gb|AAZ77693.1| ChlA1 [Streptomyces antibioticus] 791 0.0 gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 ... 783 0.0 gi|29826960|ref|NP_821594.1| modular polyketide synthase [Strept... 778 0.0 gi|15824139|dbj|BAB69303.1| modular polyketide synthase [Strepto... 777 0.0 gi|183980730|ref|YP_001849021.1| polyketide synthase Pks6 [Mycob... 776 0.0 gi|306407925|dbj|BAJ16467.1| polyketide synthase [Streptomyces g... 761 0.0 gi|183980136|ref|YP_001848427.1| polyketide synthase PKS [Mycoba... 760 0.0 gi|330467250|ref|YP_004404993.1| modular polyketide synthase [Ve... 759 0.0 gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules ... 753 0.0 gi|49146116|ref|YP_025554.1| Type I modular polyketide synthase ... 751 0.0 gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules ... 749 0.0 gi|49146124|ref|YP_025562.1| Type I modular polyketide synthase ... 749 0.0 gi|289753752|ref|ZP_06513130.1| polyketide synthase pks8 [Mycoba... 748 0.0 >gi|289443122|ref|ZP_06432866.1| polyketide synthase pks9 [Mycobacterium tuberculosis T46] gi|289750219|ref|ZP_06509597.1| polyketide synthase pks9 [Mycobacterium tuberculosis T92] gi|289753755|ref|ZP_06513133.1| polyketide synthase pks9 [Mycobacterium tuberculosis EAS054] gi|289416041|gb|EFD13281.1| polyketide synthase pks9 [Mycobacterium tuberculosis T46] gi|289690806|gb|EFD58235.1| polyketide synthase pks9 [Mycobacterium tuberculosis T92] gi|289694342|gb|EFD61771.1| polyketide synthase pks9 [Mycobacterium tuberculosis EAS054] Length=1017 Score = 2005 bits (5194), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1015/1017 (99%), Positives = 1016/1017 (99%), Gaps = 0/1017 (0%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 +QPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD Sbjct 1 MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR Sbjct 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA Sbjct 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN Sbjct 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA Sbjct 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA IDLDSLGLRV Sbjct 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAPIDLDSLGLRV 360 Query 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV Sbjct 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 Query 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL Sbjct 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 Query 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD Sbjct 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 Query 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA Sbjct 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES Sbjct 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG Sbjct 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 Query 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL Sbjct 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 Query 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS Sbjct 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 Query 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM Sbjct 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 Query 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN Sbjct 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 Query 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 >gi|15608802|ref|NP_216180.1| polyketide synthase pks9 [Mycobacterium tuberculosis H37Rv] gi|15841120|ref|NP_336157.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|148661460|ref|YP_001282983.1| putative polyketide synthase Pks9 [Mycobacterium tuberculosis H37Ra] 28 more sequence titles Length=1017 Score = 2005 bits (5194), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1016/1017 (99%), Positives = 1017/1017 (100%), Gaps = 0/1017 (0%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 +QPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD Sbjct 1 MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR Sbjct 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA Sbjct 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN Sbjct 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA Sbjct 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV Sbjct 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 Query 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV Sbjct 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 Query 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL Sbjct 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 Query 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD Sbjct 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 Query 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA Sbjct 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES Sbjct 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG Sbjct 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 Query 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL Sbjct 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 Query 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS Sbjct 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 Query 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM Sbjct 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 Query 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN Sbjct 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 Query 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 >gi|31792851|ref|NP_855344.1| polyketide synthase pks9 [Mycobacterium bovis AF2122/97] gi|121637572|ref|YP_977795.1| putative polyketide synthase pks9 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990047|ref|YP_002644734.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] 8 more sequence titles Length=1017 Score = 2003 bits (5190), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1014/1017 (99%), Positives = 1015/1017 (99%), Gaps = 0/1017 (0%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 +QPTGIAIIGLACRFPTVVSPGDLWDLLRDGREA GSIDNVADFDADFFNLSPREASAMD Sbjct 1 MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREATGSIDNVADFDADFFNLSPREASAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR Sbjct 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA Sbjct 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN Sbjct 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA Sbjct 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA IDLDSLGLRV Sbjct 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAPIDLDSLGLRV 360 Query 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV Sbjct 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 Query 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL Sbjct 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 Query 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD Sbjct 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 Query 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA Sbjct 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES Sbjct 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG Sbjct 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 Query 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL Sbjct 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 Query 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS Sbjct 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 Query 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM Sbjct 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 Query 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN Sbjct 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 Query 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 >gi|254231860|ref|ZP_04925187.1| polyketide synthase pks9 [Mycobacterium tuberculosis C] gi|124600919|gb|EAY59929.1| polyketide synthase pks9 [Mycobacterium tuberculosis C] Length=1017 Score = 2003 bits (5189), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1015/1017 (99%), Positives = 1016/1017 (99%), Gaps = 0/1017 (0%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 +QPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREA AMD Sbjct 1 MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREARAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR Sbjct 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA Sbjct 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN Sbjct 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA Sbjct 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV Sbjct 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 Query 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV Sbjct 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 Query 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL Sbjct 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 Query 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD Sbjct 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 Query 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA Sbjct 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES Sbjct 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG Sbjct 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 Query 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL Sbjct 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 Query 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS Sbjct 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 Query 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM Sbjct 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 Query 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN Sbjct 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 Query 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 >gi|289447277|ref|ZP_06437021.1| polyketide synthase pks9 [Mycobacterium tuberculosis CPHL_A] gi|289420235|gb|EFD17436.1| polyketide synthase pks9 [Mycobacterium tuberculosis CPHL_A] Length=1017 Score = 2002 bits (5187), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1013/1017 (99%), Positives = 1015/1017 (99%), Gaps = 0/1017 (0%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 +QPTGIAIIGLACRFPTVVSPGDLWDLLRDGREA GSIDNVADFDADFFNLSPREASAMD Sbjct 1 MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREATGSIDNVADFDADFFNLSPREASAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR Sbjct 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA Sbjct 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN Sbjct 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA Sbjct 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA IDLDSLGLRV Sbjct 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAPIDLDSLGLRV 360 Query 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV Sbjct 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 Query 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL Sbjct 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 Query 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD Sbjct 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 Query 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA Sbjct 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES Sbjct 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG Sbjct 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 Query 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL Sbjct 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 Query 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS Sbjct 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 Query 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM Sbjct 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 Query 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN Sbjct 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 Query 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 IPIHQLRRTGLLDK+LLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 961 IPIHQLRRTGLLDKVLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 >gi|340626669|ref|YP_004745121.1| putative polyketide synthase pks9 [Mycobacterium canettii CIPT 140010059] gi|340004859|emb|CCC44004.1| putative polyketide synthase pks9 [Mycobacterium canettii CIPT 140010059] Length=1017 Score = 1998 bits (5176), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1012/1017 (99%), Positives = 1013/1017 (99%), Gaps = 0/1017 (0%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 +QPTGIAIIGLACRFPTVVSPGDLWDLLRDGREA GSIDNVADFDADFFNLSPREASAMD Sbjct 1 MQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREATGSIDNVADFDADFFNLSPREASAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR Sbjct 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSR 120 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA Sbjct 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLK VQAALDDGDRIHAIIRGSAVGN Sbjct 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKSVQAALDDGDRIHAIIRGSAVGN 240 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA Sbjct 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRV 360 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA IDLDSLGLRV Sbjct 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAPIDLDSLGLRV 360 Query 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV Sbjct 361 DTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWV 420 Query 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL Sbjct 421 LAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGL 480 Query 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD Sbjct 481 AGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLD 540 Query 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA Sbjct 541 GQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES Sbjct 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPES 660 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG Sbjct 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 Query 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL Sbjct 721 LVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVAL 780 Query 781 LARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 LARDRPEVESVLAGVGRLF EGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS Sbjct 781 LARDRPEVESVLAGVGRLFTEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELS 840 Query 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM Sbjct 841 VDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSM 900 Query 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN Sbjct 901 SGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKN 960 Query 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 961 IPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 >gi|308231899|ref|ZP_07414188.2| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu001] gi|308379001|ref|ZP_07484619.2| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu010] gi|308380142|ref|ZP_07488842.2| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu011] gi|308215604|gb|EFO75003.1| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu001] gi|308358482|gb|EFP47333.1| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu010] gi|308362421|gb|EFP51272.1| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu011] Length=959 Score = 1889 bits (4892), Expect = 0.0, Method: Compositional matrix adjust. Identities = 959/959 (100%), Positives = 959/959 (100%), Gaps = 0/959 (0%) Query 59 MDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGT 118 MDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGT Sbjct 1 MDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLAADRVDHHAFAGT 60 Query 119 SRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARE 178 SRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARE Sbjct 61 SRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARE 120 Query 179 TAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAV 238 TAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAV Sbjct 121 TAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAV 180 Query 239 GNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEI 298 GNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEI Sbjct 181 GNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEI 240 Query 299 FAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGL 358 FAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGL Sbjct 241 FAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGL 300 Query 359 RVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVP 418 RVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVP Sbjct 301 RVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVP 360 Query 419 WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMA 478 WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMA Sbjct 361 WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMA 420 Query 479 GLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAV 538 GLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAV Sbjct 421 GLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAV 480 Query 539 LDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEI 598 LDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEI Sbjct 481 LDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEI 540 Query 599 AAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAP 658 AAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAP Sbjct 541 AAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAP 600 Query 659 ESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPR 718 ESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPR Sbjct 601 ESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPR 660 Query 719 IGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV 778 IGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV Sbjct 661 IGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV 720 Query 779 ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE 838 ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE Sbjct 721 ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE 780 Query 839 LSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD 898 LSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD Sbjct 781 LSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD 840 Query 899 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLL 958 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLL Sbjct 841 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLL 900 Query 959 KNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 KNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 901 KNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 959 >gi|289569711|ref|ZP_06449938.1| polyketide synthase pks9 [Mycobacterium tuberculosis T17] gi|289543465|gb|EFD47113.1| polyketide synthase pks9 [Mycobacterium tuberculosis T17] Length=761 Score = 1493 bits (3866), Expect = 0.0, Method: Compositional matrix adjust. Identities = 759/761 (99%), Positives = 760/761 (99%), Gaps = 0/761 (0%) Query 257 VDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNI 316 +DVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNI Sbjct 1 MDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNI 60 Query 317 GHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRA 376 GHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA IDLDSLGLRVDTALTPWPVADEPRRA Sbjct 61 GHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAPIDLDSLGLRVDTALTPWPVADEPRRA 120 Query 377 GVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRL 436 GVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRL Sbjct 121 GVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRL 180 Query 437 LAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGR 496 LAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGR Sbjct 181 LAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGR 240 Query 497 ARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADA 556 ARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADA Sbjct 241 ARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADA 300 Query 557 GLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVV 616 GLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVV Sbjct 301 GLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVV 360 Query 617 AARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDR 676 AARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDR Sbjct 361 AARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDR 420 Query 677 LVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGS 736 LVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGS Sbjct 421 LVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGS 480 Query 737 PAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVG 796 PAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVG Sbjct 481 PAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVG 540 Query 797 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQS 856 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQS Sbjct 541 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQS 600 Query 857 LAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLP 916 LAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLP Sbjct 601 LAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLP 660 Query 917 GLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLL 976 GLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLL Sbjct 661 GLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLL 720 Query 977 LLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 LLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 721 LLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 761 >gi|289761817|ref|ZP_06521195.1| polyketide synthase pks9 [Mycobacterium tuberculosis GM 1503] gi|289709323|gb|EFD73339.1| polyketide synthase pks9 [Mycobacterium tuberculosis GM 1503] Length=762 Score = 1448 bits (3748), Expect = 0.0, Method: Compositional matrix adjust. Identities = 752/762 (99%), Positives = 754/762 (99%), Gaps = 1/762 (0%) Query 257 VDVIRRAMSGAGVDC-HQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTN 315 +DVIR AMSG G + HYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTN Sbjct 1 MDVIRGAMSGGGGGLPFRFHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTN 60 Query 316 IGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRR 375 IGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRR Sbjct 61 IGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRR 120 Query 376 AGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGR 435 AGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGR Sbjct 121 AGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGR 180 Query 436 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVG 495 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVG Sbjct 181 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVG 240 Query 496 RARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD 555 RARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD Sbjct 241 RARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD 300 Query 556 AGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARV 615 AGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARV Sbjct 301 AGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARV 360 Query 616 VAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVD 675 VAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVD Sbjct 361 VAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVD 420 Query 676 RLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYG 735 RLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYG Sbjct 421 RLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYG 480 Query 736 SPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGV 795 SPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGV Sbjct 481 SPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGV 540 Query 796 GRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQ 855 GRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQ Sbjct 541 GRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQ 600 Query 856 SLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGL 915 SLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGL Sbjct 601 SLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGL 660 Query 916 PGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKL 975 PGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKL Sbjct 661 PGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKL 720 Query 976 LLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 1017 LLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 721 LLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDENDIR 762 >gi|308370786|ref|ZP_07422723.2| polyketide synthase pks9 [Mycobacterium tuberculosis SUMu003] gi|308372023|ref|ZP_07427090.2| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu004] gi|308373207|ref|ZP_07431404.2| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu005] 9 more sequence titles Length=688 Score = 1313 bits (3399), Expect = 0.0, Method: Compositional matrix adjust. Identities = 670/670 (100%), Positives = 670/670 (100%), Gaps = 0/670 (0%) Query 348 GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVA 407 GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVA Sbjct 19 GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVA 78 Query 408 AAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAV 467 AAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAV Sbjct 79 AAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAV 138 Query 468 VVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSV 527 VVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSV Sbjct 139 VVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSV 198 Query 528 FARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLP 587 FARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLP Sbjct 199 FARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLP 258 Query 588 DLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT 647 DLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT Sbjct 259 DLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT 318 Query 648 EGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSK 707 EGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSK Sbjct 319 EGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSK 378 Query 708 VLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVE 767 VLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVE Sbjct 379 VLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVE 438 Query 768 VGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFA 827 VGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFA Sbjct 439 VGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFA 498 Query 828 RQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDID 887 RQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDID Sbjct 499 RQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDID 558 Query 888 PECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHE 947 PECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHE Sbjct 559 PECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHE 618 Query 948 SSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGL 1007 SSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGL Sbjct 619 SSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGL 678 Query 1008 ALDEDENDIR 1017 ALDEDENDIR Sbjct 679 ALDEDENDIR 688 >gi|289757775|ref|ZP_06517153.1| polyketide synthase pks9 [Mycobacterium tuberculosis T85] gi|289713339|gb|EFD77351.1| polyketide synthase pks9 [Mycobacterium tuberculosis T85] Length=628 Score = 1227 bits (3174), Expect = 0.0, Method: Compositional matrix adjust. Identities = 626/628 (99%), Positives = 627/628 (99%), Gaps = 0/628 (0%) Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 +ILEQGPTQSPEIVESVAAAGSNAPVAVPWV AARSPQALTNQAGRLLAHLTADDGLTAL Sbjct 1 MILEQGPTQSPEIVESVAAAGSNAPVAVPWVWAARSPQALTNQAGRLLAHLTADDGLTAL 60 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG Sbjct 61 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 120 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL Sbjct 121 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 180 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG Sbjct 181 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 240 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV Sbjct 241 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 300 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR Sbjct 301 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 360 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSS 809 FFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSS Sbjct 361 FFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWSS 420 Query 810 VFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVEL 869 VFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVEL Sbjct 421 VFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVEL 480 Query 870 VCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYP 929 VCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYP Sbjct 481 VCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYP 540 Query 930 TASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGR 989 TASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGR Sbjct 541 TASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGR 600 Query 990 TVSDEVIDSLSPEALIGLALDEDENDIR 1017 TVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 601 TVSDEVIDSLSPEALIGLALDEDENDIR 628 >gi|183982487|ref|YP_001850778.1| polyketide synthase Pks9 [Mycobacterium marinum M] gi|183175813|gb|ACC40923.1| polyketide synthase Pks9 [Mycobacterium marinum M] Length=1029 Score = 1186 bits (3067), Expect = 0.0, Method: Compositional matrix adjust. Identities = 648/1018 (64%), Positives = 777/1018 (77%), Gaps = 16/1018 (1%) Query 4 TGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQ 63 + +AIIG+ACRFP +PG+ W+L+ +G E A ID+V DFDA+FFN+SPREA+AMDPRQ Sbjct 20 SAVAIIGVACRFPGAANPGEFWELVSEGHEVAKPIDHVGDFDAEFFNVSPREAAAMDPRQ 79 Query 64 RLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTL--AADRVDHHAFAGTSRA 121 RLALEL WEL EDA +V E++RG+PIAVYLGAMNDDYA+LTL A D++DH++FAG SR Sbjct 80 RLALELAWELFEDARIVAESVRGEPIAVYLGAMNDDYALLTLDQAPDKLDHYSFAGASRG 139 Query 122 IIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLARETA 180 +IANRVS+ F L GPS+T+D GQSSSLVAVHLA E +R G+A +AIAGG+HLNLA ET Sbjct 140 MIANRVSYGFALHGPSMTVDCGQSSSLVAVHLAREYLRGAGDATMAIAGGIHLNLASETG 199 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 LE EFGAVS SG TYAFD RADGYV +GGGLVLLKP++AAL+DG+RI A+I G+AVG+ Sbjct 200 RLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDGNRIRAVILGAAVGS 259 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGH+A GL PS A + DV+RRAM+ AGVD +Q+ Y+EAHGTGT+IGD EA+AL E+FA Sbjct 260 AGHTAGGLAAPSAAAEADVMRRAMASAGVDPNQIDYIEAHGTGTRIGDTTEAQALSEVFA 319 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVG--AAIDLDSLGL 358 R+ PV +GSVK+NIGHTG AAG AGL+K VL++EN IP SLNYVG A D++S GL Sbjct 320 TRET-PVWLGSVKSNIGHTGAAAGAAGLIKTVLSLENGAIPASLNYVGDSAGTDMESHGL 378 Query 359 RVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVP 418 V T LTPWP PRRAGVSSFGMGGTNAHVI++Q P I + A VP Sbjct 379 HVSTTLTPWPRGAGPRRAGVSSFGMGGTNAHVIVQQAP-----IPQEAVADPDGTEATVP 433 Query 419 WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMA 478 W+++ARS AL QA RL A + + DVGWSL+STRSVF+HRAV+VG DRG MA Sbjct 434 WLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTRSVFEHRAVLVGGDRGGFMA 493 Query 479 GLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAV 538 GLA LA+GEPG +V GRA S GKTV VFPGQG+QWLGMGR LYGR+ FA+AFD V Sbjct 494 GLAALASGEPGVNLVAGRAGSGGKTVLVFPGQGAQWLGMGRDLYGRFPAFAKAFDTVADA 553 Query 539 LDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEI 598 LD LRL +R+V+WGADA LLE TEFAQPALF ++VALAALLQ GV+ DLVMGHSVGEI Sbjct 554 LDEHLRLPLREVIWGADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEI 613 Query 599 AAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAP 658 +AA+VAG LSL DAAR+V+ARGRLM LP GGVMVAVAAS +VAP+L EGV IAAVN P Sbjct 614 SAAHVAGVLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLEEGVSIAAVNGP 673 Query 659 ESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPR 718 +SVVISG +AA VV DRL G G R RLAVSHAFHS LM+PM+ +F ++ + PR Sbjct 674 DSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEPMMAQFGATISGIVAHEPR 733 Query 719 IGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV 778 I LVS +TGQLA AGYG+ +YWVEHVRKPVRF DGV LAESLGA F+E GP AGL SV Sbjct 734 IALVSTMTGQLAAAGYGTASYWVEHVRKPVRFADGVALAESLGAATFLETGPSAGLGTSV 793 Query 779 ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE 838 ALLA+ RPEVES+L +G+L+ +G +DW + FAGL R V LPTY FARQRFWLG+ Sbjct 794 ALLAKGRPEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLGEGAG 853 Query 839 LSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD 898 D + ++G RL S+ E RQLV+LVC HAAIV G +SH ID E AFQDLGF+ Sbjct 854 RKADSS-DESGLRPRLDSVDSKERFRQLVDLVCLHAAIVTGHSNSHQIDAERAFQDLGFE 912 Query 899 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLG-QLLGGQHESSDDESIWQL 957 SM+GVELRNRL+ + GL+L RT+IFDYPT ALA L QL GG HE SDD+ IW + Sbjct 913 SMTGVELRNRLR---AVTGLALSRTIIFDYPTPMALARHLDEQLSGGNHEESDDDKIWSV 969 Query 958 LKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDEND 1015 L+ IP+ +LRR+G+LDKLLLLAGQ E VSD+VIDSLSPEAL+ +ALD +++D Sbjct 970 LRTIPVRELRRSGMLDKLLLLAGQDESPAPDAAVSDDVIDSLSPEALVAMALDSEDDD 1027 >gi|254820899|ref|ZP_05225900.1| polyketide synthase [Mycobacterium intracellulare ATCC 13950] Length=1033 Score = 1183 bits (3061), Expect = 0.0, Method: Compositional matrix adjust. Identities = 658/1037 (64%), Positives = 763/1037 (74%), Gaps = 35/1037 (3%) Query 4 TGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQ 63 T +AIIGLAC+FP P LW L+RDGRE FDADFFNLSPREA AMDPRQ Sbjct 4 TDVAIIGLACKFPGAAGPQALWRLIRDGRENTQFAGEAQQFDADFFNLSPREACAMDPRQ 63 Query 64 RLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA--ADRVDHHAFAGTSRA 121 RLALELTWEL E+AF+VP+TLR +P++VYLG M DDYA LTL AD +DHH F G SRA Sbjct 64 RLALELTWELFENAFIVPDTLRTEPVSVYLGVMTDDYAALTLRDLADNLDHHTFTGISRA 123 Query 122 IIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETAM 181 +IANR+S+AFGL+GPS+T+DSGQSSSLVAVHL CESVRTG++ LAIAGGVHLNLA E AM Sbjct 124 MIANRISYAFGLQGPSMTVDSGQSSSLVAVHLGCESVRTGQSSLAIAGGVHLNLADEIAM 183 Query 182 LEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNA 241 LE+EFGAVS SGHTYAFD RADGYV G+G GLVLLKP+ AALDDGDRIHA+IRGSAV NA Sbjct 184 LEREFGAVSVSGHTYAFDRRADGYVRGEGAGLVLLKPLPAALDDGDRIHAVIRGSAVANA 243 Query 242 GHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAA 301 GHS G TVPS G+ DVIR A++ AG+D + YVEAHGTGTK+GD IEA+ALGE+F Sbjct 244 GHSPAGQTVPSARGEADVIRGALADAGLDAADIDYVEAHGTGTKVGDAIEAQALGEVFGV 303 Query 302 RQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA--AIDLDSLGLR 359 R PV VGSVKTNIGH GGAAG+ GLLKAVL+I ++ IPPSLN+ G +DL+ LGL+ Sbjct 304 RAHDPVRVGSVKTNIGHAGGAAGVTGLLKAVLSIHHSTIPPSLNHAGPDPEVDLNRLGLQ 363 Query 360 VDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPW 419 V+T PWP PRRAGVSSFGMGGTNAH+++EQ P Q P+ AA S+ + VPW Sbjct 364 VNTVAVPWPSTRHPRRAGVSSFGMGGTNAHLVVEQPPAQ-PD------AAQSDPGLTVPW 416 Query 420 VLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAG 479 VL+ARS +ALTNQA RL HL + LT LDVGWSLVSTR+ F+HRAVVVG +RG L G Sbjct 417 VLSARSERALTNQARRLSDHLAEREDLTPLDVGWSLVSTRASFEHRAVVVGGNRGELATG 476 Query 480 LAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVL 539 LA LAAG+P +GV VGR GKTVFVFPGQGSQWLGMGRQLY R+ VFAR FDE V V+ Sbjct 477 LAALAAGQPHSGVSVGRGMPPGKTVFVFPGQGSQWLGMGRQLYDRFEVFARTFDEAVEVV 536 Query 540 DGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIA 599 DG +RL +R+VMWGAD LL+STEFAQPALF + +ALAAL Q +GV PD+VMGHSVGEI Sbjct 537 DGHVRLPLREVMWGADPELLQSTEFAQPALFALGIALAALWQSFGVAPDVVMGHSVGEIT 596 Query 600 AAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPE 659 AA VAGALSL D+AR+VAARGRLM LPAGGVMVAV A E EVA L+ GV IAAVN P+ Sbjct 597 AACVAGALSLPDSARLVAARGRLMGRLPAGGVMVAVGAGEAEVAALMDGGVSIAAVNGPQ 656 Query 660 SVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRI 719 SVV+SGEQ V + DRL GRRV RLAVSHAFHS LM+PM+ EFS A + R PR+ Sbjct 657 SVVLSGEQTPVAALADRLAQTGRRVHRLAVSHAFHSPLMEPMLGEFSAAAAGIEPRRPRV 716 Query 720 GLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLE---- 775 LVSN+TG+ A A YGS YWVEHVR+PVRFF+GV AE+ GA +F+E+GPGA L Sbjct 717 ELVSNLTGRPADAEYGSAQYWVEHVRRPVRFFEGVRAAEAGGAAIFLELGPGAALTAAVD 776 Query 776 --------ASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFA 827 AS+A + +DRPE ES LA G+LF G+ +DW+ VFAGL RRVELPTYGFA Sbjct 777 QSLSAERAASLATMPKDRPETESTLAAAGQLFTRGLDLDWAGVFAGLNARRVELPTYGFA 836 Query 828 RQRFWLGDNGELSVDQTG-----KDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKS 882 R RFWLGD + RL L E QR L+ LVC HAA VLG Sbjct 837 RDRFWLGDGRGPGGSGAAPATVTRSPDLAQRLHGLPRDEQQRVLLGLVCEHAAAVLGYPG 896 Query 883 SHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL-GQL 941 ID + AF DLGFDS++GVELRNRL G +L RT+IFDYPT +ALA+ L QL Sbjct 897 GQAIDHDRAFGDLGFDSLTGVELRNRLTTHA---GTALSRTVIFDYPTPAALADHLRRQL 953 Query 942 LGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRT---VSDEVIDS 998 L E SDDE +W L+ IP+ +LRRTGLLDKLLLLAG PE S + IDS Sbjct 954 LHDDREESDDEKLWSALRRIPVRELRRTGLLDKLLLLAGVPETPDGDANEPGPSGDDIDS 1013 Query 999 LSPEALIGLALDEDEND 1015 LSP+ LI +ALD E+D Sbjct 1014 LSPDDLIAMALDAAEDD 1030 >gi|118464601|ref|YP_882291.1| polyketide synthase [Mycobacterium avium 104] gi|118165888|gb|ABK66785.1| polyketide synthase [Mycobacterium avium 104] Length=1034 Score = 1183 bits (3061), Expect = 0.0, Method: Compositional matrix adjust. Identities = 663/1037 (64%), Positives = 762/1037 (74%), Gaps = 32/1037 (3%) Query 3 PTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPR 62 PT +AIIG+ACRFP PG W LLRDGRE A+FDADFFNLSPREA+AMDPR Sbjct 3 PTDVAIIGMACRFPGAPDPGSFWRLLRDGREVTRFAGEAAEFDADFFNLSPREAAAMDPR 62 Query 63 QRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTL--AADRVDHHAFAGTSR 120 QRLALEL WELLEDAF+V ETLRG+ ++VYLGAM DDYA LTL D VDHH F G SR Sbjct 63 QRLALELAWELLEDAFIVAETLRGEAVSVYLGAMTDDYAALTLRDVPDNVDHHTFTGVSR 122 Query 121 AIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETA 180 +IANR+S+ GLRG S+T+DSGQSSSLVAVHL CESVR+G+APLAIAGGVHLNLA E A Sbjct 123 GMIANRISYLLGLRGASMTVDSGQSSSLVAVHLGCESVRSGQAPLAIAGGVHLNLADEIA 182 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 +LE+EFGAVS SGHTYAFD RADGYV G+GGGLVLLKP+ AA DGDRIHA+IR +AVGN Sbjct 183 LLEREFGAVSVSGHTYAFDRRADGYVRGEGGGLVLLKPLAAARRDGDRIHAVIRATAVGN 242 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGH A T+PS A + DVI RA++ AG+ + YVEAHGTGT++GD +E +ALG IFA Sbjct 243 AGHGAPAQTLPSAAAEADVIGRALAEAGLGGADIDYVEAHGTGTRVGDAVETQALGRIFA 302 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNY--VGAAIDLDSLGL 358 R PVSVGSVKTNIGH AAGIAGLLKAVLAIE+A IPP+L++ IDL+ LGL Sbjct 303 ERSHHPVSVGSVKTNIGHAASAAGIAGLLKAVLAIEHAAIPPNLHFERPDPDIDLNRLGL 362 Query 359 RVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVP 418 RV+TAL PWP PRRAGVSSFGMGGTNAHVI+EQ Q ++ A + A VA+P Sbjct 363 RVNTALAPWPDRGGPRRAGVSSFGMGGTNAHVIVEQDAAQ-----QNPTPASAPADVALP 417 Query 419 WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMA 478 WVL+ARS +AL QA RL AHL + LDVGWSLVS R+VF+HRAV+VG +RG L Sbjct 418 WVLSARSERALALQAQRLSAHLAERPQASPLDVGWSLVSARAVFEHRAVLVGCERGVLAT 477 Query 479 GLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAV 538 GLAG+A+G P A VVGRAR+ GKTV VFPGQGSQ LGMGRQLY R+ VFARA DE VAV Sbjct 478 GLAGVASGRPDAATVVGRARATGKTVLVFPGQGSQTLGMGRQLYERFVVFARALDEAVAV 537 Query 539 LDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEI 598 +D RLSVR+VMWGAD LL+STEFAQPALFV +VALAAL + GV PD+VMGHSVGEI Sbjct 538 VDEHSRLSVREVMWGADPELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEI 597 Query 599 AAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAP 658 AAA VAG LSL DAAR+VAARG LM ALP GGVMVAV A+E +VAPL+ GV IAAVN P Sbjct 598 AAACVAGVLSLRDAARLVAARGALMAALPPGGVMVAVTATEAQVAPLVGGGVSIAAVNGP 657 Query 659 ESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPR 718 ++VV+SGEQ AV V +RL G G RV RLAVSHAFHS LM+PM++ F+ A + R PR Sbjct 658 DAVVLSGEQEAVSAVAERLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAGIEPRPPR 717 Query 719 IGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV 778 I LVSN+TGQLAG GYG+P YWVEHVR+PVRF DGV LAES GA VF+EVGPGA L A+V Sbjct 718 IPLVSNLTGQLAGPGYGTPQYWVEHVRRPVRFVDGVRLAESQGAGVFLEVGPGAALTAAV 777 Query 779 ------------ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGF 826 A L +DRPE ES L G LF G +DW+ VFAGL RRV+LPTY F Sbjct 778 DQSLSTEGATAIATLPKDRPETESALHAAGHLFTRGHRLDWAGVFAGLPARRVDLPTYAF 837 Query 827 ARQRFWLGDNGELSVDQTGKDAGAIA-------RLQSLAPPELQRQLVELVCFHAAIVLG 879 AR+RFWLG G RL +L E QR L ELVC HAA VLG Sbjct 838 ARERFWLGGASLAGAPAGAAPVGGGTRAPELAHRLHALPRDEQQRVLRELVCEHAAAVLG 897 Query 880 RKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL- 938 IDP+ AF DLGFDS+ GVELRNRL G +L RTLIFDYPT +ALA+ L Sbjct 898 HPGGDAIDPDRAFADLGFDSLIGVELRNRLTTHT---GTALSRTLIFDYPTPAALADHLR 954 Query 939 GQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDS 998 QLL + SDDE IW L+ IP+ +LRRTGLLDKLLLLAG PE + +SD IDS Sbjct 955 QQLLHDEDPESDDERIWSALRRIPLRELRRTGLLDKLLLLAGMPETATTDAKISDADIDS 1014 Query 999 LSPEALIGLALDEDEND 1015 LSP+ALI +AL+ ++D Sbjct 1015 LSPDALIAMALNSADDD 1031 >gi|240170123|ref|ZP_04748782.1| polyketide synthase Pks9 [Mycobacterium kansasii ATCC 12478] Length=1014 Score = 1175 bits (3040), Expect = 0.0, Method: Compositional matrix adjust. Identities = 660/1023 (65%), Positives = 784/1023 (77%), Gaps = 15/1023 (1%) Query 1 VQPTGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMD 60 + P IAIIGLACRFP PG+ W +LRDGRE AG + ADFDA+FF++SPREA+AMD Sbjct 1 MNPGDIAIIGLACRFPAAPGPGEFWQVLRDGRETAGPMAGSADFDAEFFDISPREAAAMD 60 Query 61 PRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTL--AADRVDHHAFAGT 118 PRQRLALEL WELLEDAF+VPET+R + ++VYLGAMNDDY+ LTL A + VDH++FAG Sbjct 61 PRQRLALELAWELLEDAFIVPETVRARQVSVYLGAMNDDYSSLTLRNATENVDHYSFAGV 120 Query 119 SRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARE 178 SRA+IANRVS+AF L GPS+T+DSGQSSSLVAVHLACES+R G + AIAGGVHLN+A E Sbjct 121 SRAMIANRVSYAFALHGPSMTVDSGQSSSLVAVHLACESLRAGTSEQAIAGGVHLNVASE 180 Query 179 TAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAV 238 TA+LE+EFGAVS SGHTYAFD RADGYV G+GGGLVLLKP+ AAL DG+RI A+I GSAV Sbjct 181 TALLEREFGAVSTSGHTYAFDGRADGYVRGEGGGLVLLKPLHAALADGNRIRAVIVGSAV 240 Query 239 GNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEI 298 GNAGHS+ GLT PS + + DVIRRA++ AGVDC V YVEAHGTGT+IGDP EA ALG+I Sbjct 241 GNAGHSSAGLTAPSTSAEADVIRRALAQAGVDCTGVDYVEAHGTGTRIGDPAEAAALGQI 300 Query 299 FAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGA--AIDLDSL 356 FA R+ PV VGSVKTNIGH G AAGIAGL+K VLAIEN IP SLNYV A AI+++SL Sbjct 301 FAQRRHDPVRVGSVKTNIGHAGAAAGIAGLIKTVLAIENESIPASLNYVSASSAINVESL 360 Query 357 GLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVA 416 GL+V+T WP PRRAGVSSFGMGGTNAH++L+Q P ES A N Sbjct 361 GLQVNTVPAGWPDWGRPRRAGVSSFGMGGTNAHLLLQQAPA-----TESAAMPRVNKSTG 415 Query 417 VPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRL 476 +PWVL+ARS AL NQ RLLA + L A+DVGWSLVSTRSVF+HRAVVVG+ R +L Sbjct 416 LPWVLSARSAPALANQVQRLLARMDERPDLDAVDVGWSLVSTRSVFEHRAVVVGSGRAQL 475 Query 477 MAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVV 536 ++GLAGLAAGEPGAGV VGRA+ VGKT FVFPGQG Q+LGMGR L R+ VF +AFD Sbjct 476 LSGLAGLAAGEPGAGVAVGRAQRVGKTAFVFPGQGVQYLGMGRGLCERFPVFGKAFDAAA 535 Query 537 AVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVG 596 LD LRL +R+V+WG DA +L++TEFAQPALF V+VALAALL + GV+PD+V+GHSVG Sbjct 536 EALDEHLRLPLRRVLWGTDAAVLQNTEFAQPALFAVEVALAALLAEMGVVPDIVLGHSVG 595 Query 597 EIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVN 656 EIAAA VAG LSL DAARVVA R RLM LPAGG MVAVAASEDEVA +L GV IAAVN Sbjct 596 EIAAAQVAGVLSLPDAARVVAVRARLMAGLPAGGAMVAVAASEDEVASVLAPGVEIAAVN 655 Query 657 APESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRA 716 AP+SVVISG + AV V DRL G GRRVRRLAVSHAFHS M+PM+ F LA + V Sbjct 656 APDSVVISGPELAVNAVADRLAGTGRRVRRLAVSHAFHSASMEPMLAGFGAALAGLPVSR 715 Query 717 PRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA 776 PRI LVSNVTG++ GA YGS AYWVEHVRKPVR +G+ LAES GA F+EVGP AGL Sbjct 716 PRITLVSNVTGRVVGADYGSAAYWVEHVRKPVRLAEGILLAESSGATTFLEVGPCAGLTT 775 Query 777 SVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 S ALLA+D PE ES+L +G+LF EGV++DW FAGLG R VELPTYGFARQRFWLG+ Sbjct 776 SPALLAKDHPEAESLLTAMGQLFTEGVSMDWPKAFAGLGARPVELPTYGFARQRFWLGEG 835 Query 837 GELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLG 896 ++ G+ L P E R L++LVC +AA VLG SS ID AF+D+G Sbjct 836 TRHDIEHAGRST-LWHHWNELDPAERHRLLLDLVCRNAAAVLGDSSSRRIDTGRAFEDVG 894 Query 897 FDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQH-ESSDDESIW 955 F+SM+G+ELRNRL A GL+L RTLIFDYPT +A+A LG+ L + DE +W Sbjct 895 FESMTGIELRNRLAAAT---GLTLSRTLIFDYPTPTAVARHLGERLSSSGLDEPGDEQVW 951 Query 956 QLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALD-EDEN 1014 LL++IP+ +LRRTGLL KLL+LAGQ E ++ TV+++VID+LSP+AL+ +AL+ D+N Sbjct 952 PLLRSIPLRELRRTGLLGKLLVLAGQAENTVRESTVTEDVIDALSPDALVAMALEPSDDN 1011 Query 1015 DIR 1017 ++ Sbjct 1012 SLQ 1014 >gi|118617289|ref|YP_905621.1| polyketide synthase Pks9 [Mycobacterium ulcerans Agy99] gi|118569399|gb|ABL04150.1| polyketide synthase Pks9 [Mycobacterium ulcerans Agy99] Length=1030 Score = 1167 bits (3018), Expect = 0.0, Method: Compositional matrix adjust. Identities = 642/1018 (64%), Positives = 770/1018 (76%), Gaps = 16/1018 (1%) Query 4 TGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQ 63 + +AIIG+ACR P +PG+ W+L+ +G E A ID+V DFDA+FFN+SPREA+AMDPRQ Sbjct 21 SAVAIIGVACRIPGAANPGEFWELVSEGHEVAKPIDHVGDFDAEFFNVSPREATAMDPRQ 80 Query 64 RLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTL--AADRVDHHAFAGTSRA 121 RLALEL WEL EDA +V E++RG+PIAVYLGAMNDDYA+LTL A D++DH++FAG SR Sbjct 81 RLALELAWELFEDARIVAESVRGEPIAVYLGAMNDDYALLTLDQAPDKLDHYSFAGASRG 140 Query 122 IIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVR-TGEAPLAIAGGVHLNLARETA 180 +IANRVS F L GPS+T+D GQSSSLVAVHLA +R G+A +AIAGG+HLNLA ET Sbjct 141 MIANRVSSGFALHGPSMTVDCGQSSSLVAVHLAPGYLRGAGDATMAIAGGIHLNLASETG 200 Query 181 MLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGN 240 LE EFGAVS SG TYAFD RADGYV +GGGLVLLKP++AAL+DG+ I A+I G AVG+ Sbjct 201 RLETEFGAVSASGRTYAFDARADGYVRSEGGGLVLLKPLRAALEDGNSIRAVILGEAVGS 260 Query 241 AGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFA 300 AGH+A GL PS A + DV+RRAM+ AGVD +Q+ Y+EAHGTGT+IGD EA+AL E+FA Sbjct 261 AGHTAGGLAAPSAAAEADVMRRAMASAGVDPNQIDYIEAHGTGTRIGDTTEAQALSEVFA 320 Query 301 ARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVG--AAIDLDSLGL 358 R+ PV +GSVK+NIGHTG AAG AGL+K VL++EN IP SLN+VG A D++S GL Sbjct 321 TRET-PVWLGSVKSNIGHTGAAAGAAGLIKTVLSLENGAIPASLNFVGDSAGTDMESHGL 379 Query 359 RVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVP 418 V T LTPWP PRRAGVSSFGMGGTNAHVI++Q P I + A VP Sbjct 380 HVSTTLTPWPRGAGPRRAGVSSFGMGGTNAHVIVQQAP-----IPQEAVADPDGTEATVP 434 Query 419 WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMA 478 W+++ARS AL QA RL A + + DVGWSL+STRSVF+HRAV+VG DRG MA Sbjct 435 WLVSARSRAALAGQAQRLAAWVAELPSIDVADVGWSLLSTRSVFEHRAVLVGGDRGGFMA 494 Query 479 GLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAV 538 GLA LA+GEPG +V GRA S GKTV VFPGQG+QWLGMGR LYGR+ FA+AFD V Sbjct 495 GLAALASGEPGVNLVAGRAGSGGKTVLVFPGQGAQWLGMGRDLYGRFPAFAKAFDTVADA 554 Query 539 LDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEI 598 LD LRL +R+V+WGADA LLE TEFAQPALF ++VALAALLQ GV+ DLVMGHSVGEI Sbjct 555 LDEHLRLPLREVIWGADASLLEGTEFAQPALFALEVALAALLQACGVVADLVMGHSVGEI 614 Query 599 AAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAP 658 +AA+VAG LSL DAAR+V+ARGRLM LP GGVMVAVAAS +VAP+L EGV IAAVN P Sbjct 615 SAAHVAGVLSLTDAARLVSARGRLMAQLPPGGVMVAVAASAAQVAPMLQEGVSIAAVNGP 674 Query 659 ESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPR 718 +SVVISG +AA VV DRL G G R RLAVSHAFHS LM+PM+ +F ++ + PR Sbjct 675 DSVVISGPEAATAVVADRLTGQGCRAHRLAVSHAFHSALMEPMMVQFGATISGIVAHEPR 734 Query 719 IGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV 778 I LVSN+TGQLA AGYG+ +YWVEHVRKPVRF DGV LAESLGA F+E GP AGL SV Sbjct 735 IALVSNMTGQLAAAGYGTASYWVEHVRKPVRFADGVALAESLGAATFLETGPSAGLGTSV 794 Query 779 ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE 838 ALLA+ RPEVES+L +G+L+ +G +DW + FAGL R V LPTY FARQRFWLG+ Sbjct 795 ALLAKGRPEVESLLTAMGQLYVDGADLDWRAAFAGLRARTVTLPTYSFARQRFWLGEGAG 854 Query 839 LSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD 898 D + ++G RL S+ E RQLV+LVC HAAI G +SH ID E AFQ LGF+ Sbjct 855 RKADSS-DESGLRPRLDSVDSKERFRQLVDLVCLHAAIATGHSNSHQIDAERAFQGLGFE 913 Query 899 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLG-QLLGGQHESSDDESIWQL 957 SM+GVELRNRL+ + GL+L RT+IFDY T ALA L QL GG HE SDD+ IW + Sbjct 914 SMTGVELRNRLR---AVTGLALSRTIIFDYTTPMALARHLDEQLSGGNHEESDDDKIWSV 970 Query 958 LKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDEND 1015 L+ IP+ +LRR+G+LDKLLLLAGQ E VSD+VIDSLSPEAL+ +ALD +++D Sbjct 971 LRTIPVRELRRSGMLDKLLLLAGQDERPAPDAAVSDDVIDSLSPEALVAMALDSEDDD 1028 >gi|342860753|ref|ZP_08717403.1| polyketide synthase [Mycobacterium colombiense CECT 3035] gi|342131777|gb|EGT85034.1| polyketide synthase [Mycobacterium colombiense CECT 3035] Length=1034 Score = 1130 bits (2922), Expect = 0.0, Method: Compositional matrix adjust. Identities = 660/1037 (64%), Positives = 759/1037 (74%), Gaps = 34/1037 (3%) Query 4 TGIAIIGLACRFPTVVSPGDLWDLLRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQ 63 T +AIIGLACRFP PG W L+RDGREA A+FDADFFNLSPREASAMDPRQ Sbjct 4 TDVAIIGLACRFPAAAGPGAFWRLIRDGREATRFTGEAAEFDADFFNLSPREASAMDPRQ 63 Query 64 RLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA--ADRVDHHAFAGTSRA 121 RLALELTWEL EDA ++PETLRG+P++V+LGAM DDYA LTL AD +DHH+F G SRA Sbjct 64 RLALELTWELFEDALLIPETLRGEPVSVFLGAMTDDYAALTLRDLADNLDHHSFTGISRA 123 Query 122 IIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLAIAGGVHLNLARETAM 181 +IANR+S+AFGLRGPS+T+DSGQSSSLVAVHL CESV TG + LAIAGGVHLNLA E M Sbjct 124 MIANRISYAFGLRGPSMTVDSGQSSSLVAVHLGCESVATGRSALAIAGGVHLNLADEIGM 183 Query 182 LEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNA 241 LE+EFGAVS SGHTYAFD RADGYV G+GGGLVLLK + +ALDDGDRIHA+IRG AVGNA Sbjct 184 LEREFGAVSVSGHTYAFDRRADGYVRGEGGGLVLLKALPSALDDGDRIHAVIRGGAVGNA 243 Query 242 GHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAA 301 G+ AT TVPS +G+ DVIRRA++ AG+ + Y+EAHGTGTK+GD IEA+ALG++FA Sbjct 244 GNGATAQTVPSASGEADVIRRALAAAGLRGGDIDYIEAHGTGTKVGDAIEAQALGQVFAE 303 Query 302 RQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVD 361 R PV VGSVKTNIGH GGAAGIAGLLKAVLAIE+ IPPSLNY A +L+ LGL+V+ Sbjct 304 RAHDPVRVGSVKTNIGHAGGAAGIAGLLKAVLAIEHGAIPPSLNYADPATELNHLGLQVN 363 Query 362 TALTPWPVADEPRRAGVSSFGMGGTNAHVILEQ--GPTQSPEIVESVAAAGSNAPVAVPW 419 TALTPWP RRAGVSSFGMGGTNAH+++EQ P+ P A ++ +PW Sbjct 364 TALTPWPPVARARRAGVSSFGMGGTNAHLVVEQFERPSAQPH------AQPADPDEILPW 417 Query 420 VLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAG 479 VL+ RS QAL NQA RL A+LT ++ LD+ WSLV TR+VF+HRAVVVG DR L G Sbjct 418 VLSGRSEQALANQARRLSAYLTDRADVSPLDIAWSLVGTRTVFEHRAVVVGGDRAALATG 477 Query 480 LAGLAAGEPGAGVVVGRA---RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVV 536 LA LAAGE G GV VGRA S+GKTVFVFPGQGSQWLGMGRQLY R+ VFARA DE Sbjct 478 LAALAAGESGPGVAVGRAGSSESLGKTVFVFPGQGSQWLGMGRQLYERFGVFARALDEAA 537 Query 537 AVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVG 596 A +D LR +R+VMWGAD LL +TEFAQPALF + VAL AL Q +GV PD+VMGHSVG Sbjct 538 AAVDAHLRAPLREVMWGADPDLLRNTEFAQPALFAIGVALTALWQSFGVTPDVVMGHSVG 597 Query 597 EIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVN 656 EI AA VAG LSL DA+ +VAARGRLM LPAGGVMVAV A+E EV LL GV IAAVN Sbjct 598 EITAACVAGVLSLADASLMVAARGRLMSGLPAGGVMVAVGAAEAEVTGLLDGGVSIAAVN 657 Query 657 APESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRA 716 P++VV+SG QA V + DRL GRRVRRLAVSHAFHS LM PMV EFS +A + V Sbjct 658 GPDAVVLSGAQAPVDALADRLARAGRRVRRLAVSHAFHSPLMQPMVAEFSAAVAGIEVGE 717 Query 717 PRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA 776 PRI LVSNVTGQLA GYGSP YW +HV PVRFF+GV AE+ GA +F+E+GPGA L A Sbjct 718 PRIALVSNVTGQLAEDGYGSPRYWADHVGHPVRFFEGVRAAEAAGAGIFLELGPGAALTA 777 Query 777 ------------SVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTY 824 SV LA+DRPE ES+L G+LF G+ +W++ FAGL R VELPTY Sbjct 778 AVDQSLSAERAVSVPCLAKDRPEAESLLGAAGQLFTRGLDPNWAAAFAGLNARCVELPTY 837 Query 825 GFARQRFWLGDNGELSVDQTGKDAGAIA----RLQSLAPPELQRQLVELVCFHAAIVLGR 880 GF RQRFWLG G + A RL L P + +R LVELVC HAA V G Sbjct 838 GFVRQRFWLGAEGAGATGGPPATASRTPDLAHRLLGLPPDDQRRALVELVCEHAAAVSGH 897 Query 881 KSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL-G 939 H IDP AF DLGFDSM GVELRNRL GL+L RTLIFDYPT +ALAE L Sbjct 898 PGGHAIDPGRAFGDLGFDSMIGVELRNRLTSHT---GLALSRTLIFDYPTPAALAEHLRR 954 Query 940 QLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAGRTVSDEVIDSL 999 QLL + SD+E IW L+ IP+ +LRRTGLL+KLLLLAG PE + ID+L Sbjct 955 QLLHDEPAESDEEKIWSELRKIPVRELRRTGLLEKLLLLAGAPESPAPDANSGADDIDAL 1014 Query 1000 SPEALIGLALDE-DEND 1015 SP+ALI +AL DE D Sbjct 1015 SPDALIAMALSSADEED 1031 >gi|336457823|gb|EGO36817.1| polyketide synthase family protein [Mycobacterium avium subsp. paratuberculosis S397] Length=1095 Score = 916 bits (2368), Expect = 0.0, Method: Compositional matrix adjust. Identities = 550/1066 (52%), Positives = 686/1066 (65%), Gaps = 65/1066 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +A++G+ACR+ V SP LWDL+ +GR+ Sbjct 36 VAVVGMACRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQ 95 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + DFDA FF + P EA AMDP+QR+ LE+ WE LE A + P LRG V+ G Sbjct 96 GSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSALRGTATGVFAG 155 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y ++ + G++ ++ + RVS+ GL GP+V++D+ SSSLVA+HLA Sbjct 156 VIHAGYG--GEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVDTACSSSLVAMHLA 213 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+GE LA+AGGV + +A A +E A++P G + ADG +G G+ Sbjct 214 AQSLRSGECDLALAGGVTV-MATPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGV 272 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++L+ + A G + A++RGSAV G S GLT P+ Q VIR A++ AG+ Sbjct 273 LVLERLGDARRLGHPVWAVLRGSAVNQDGAS-NGLTAPNGPSQQRVIRAALANAGLSAVD 331 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VE HGTGT +GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+AG++K Sbjct 332 VDVVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKM 391 Query 332 VLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V AI + V+P +L + +D + + + T PWP PRRAGVSSFG+ GTNAH Sbjct 392 VQAIRHGVMPKTLHVDVPSPHVDWSAGAVSLLTDPRPWPEHGGPRRAGVSSFGISGTNAH 451 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ P + ++A +A VPWV++ARS +AL QA RLL H+TAD + L Sbjct 452 VIVEQAPAAAETEAAPASSAMPDA--VVPWVVSARSAEALAGQARRLLDHVTADAQASPL 509 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVGWSLVSTR+VF+HRAVVVG +RG L GLAGLA+G P A VVGRAR+ GKTV VFPG Sbjct 510 DVGWSLVSTRAVFEHRAVVVGCERGALATGLAGLASGRPDAATVVGRARATGKTVLVFPG 569 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMGRQLY R+ VFARA DE VAV+D RL VR+VMWGAD LL+STEFAQPAL Sbjct 570 QGSQTLGMGRQLYERFVVFARALDEAVAVVDEHSRLPVREVMWGADPELLQSTEFAQPAL 629 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 FV +VALAAL + GV PD+VMGHSVGEIAAA VAG LSL DAAR+VAARG LM ALPAG Sbjct 630 FVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLPDAARLVAARGALMAALPAG 689 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAV A E +VAPL+ GV IAAVN P++VV+SGEQ AV V +RL G G RV RLAV Sbjct 690 GVMVAVTAGEAQVAPLVGGGVSIAAVNGPDAVVLSGEQEAVAAVAERLAGSGARVHRLAV 749 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LM+PM++ F+ A + R PRI LVSN+TGQLAG GYG+P YWVEHVR+PV+ Sbjct 750 SHAFHSALMEPMLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGTPQYWVEHVRRPVQ 809 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEASV------------ALLARDRPEVESVLAGVGR 797 F GV AE GA F+E+GPGA L A+V A L +DRPE ES L G Sbjct 810 FLAGVRAAEQAGAGTFLELGPGAALTAAVDQSLSTEGATAIATLPKDRPETESALHAAGH 869 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIA----- 852 LF G +DW+ VFAGL RRVELPTY FAR+RFWLG G Sbjct 870 LFTRGHRLDWAGVFAGLPARRVELPTYAFARERFWLGGASLAGAPAGAAPVGGGTRAPEL 929 Query 853 --RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQ 910 RL +L E QR L ELVC HAA VLG IDP AF DLGFDS+ GVELRNRL Sbjct 930 AHRLHALPRDEQQRVLRELVCEHAAAVLGHPDGDAIDPHRAFADLGFDSLIGVELRNRLT 989 Query 911 MAIGLPGLSLPRTLIFDYPTASALAECL-GQLLGGQHESSDDESIWQLLKNIPIHQLRRT 969 G +L RTLIFDYPT +ALA+ L QLL + SDDE IW L+ IP+ +LRRT Sbjct 990 THT---GTALSRTLIFDYPTPTALADHLRRQLLHDEDPESDDERIWSALRRIPLRELRRT 1046 Query 970 GLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDEND 1015 GLLDKLLLLAG PE + +SD IDSLSP+ALI +AL+ ++D Sbjct 1047 GLLDKLLLLAGIPETATTDPKISDADIDSLSPDALIAMALNSADDD 1092 >gi|41407469|ref|NP_960305.1| Pks8 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41395821|gb|AAS03688.1| Pks8 [Mycobacterium avium subsp. paratuberculosis K-10] Length=1095 Score = 911 bits (2355), Expect = 0.0, Method: Compositional matrix adjust. Identities = 550/1066 (52%), Positives = 684/1066 (65%), Gaps = 65/1066 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +A++G+ACR+ V SP LWDL+ +GR+ Sbjct 36 VAVVGMACRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQ 95 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + DFDA FF + P EA AMDP+QR+ LE+ WE LE A + P LRG V+ G Sbjct 96 GSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSALRGTATGVFAG 155 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y ++ + G++ ++ + RVS+ GL GP+V++D+ SSSLVA+HLA Sbjct 156 VIHAGYG--GEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVDTACSSSLVAMHLA 213 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+GE LA+AGGV + +A A +E A++P G + ADG +G G+ Sbjct 214 AQSLRSGECDLALAGGVTV-MATPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGV 272 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++L+ + A G + A++RGSAV G S GLT P+ Q VIR A++ AG+ Sbjct 273 LVLERLGDARRLGHPVWAVLRGSAVNQDGAS-NGLTAPNGPSQQRVIRAALANAGLSAVD 331 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VE HGTGT +GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+AG++K Sbjct 332 VDVVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKM 391 Query 332 VLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V AI + V+P +L + +D + + + T PWP PRRAGVSSFG+ GTNAH Sbjct 392 VQAIRHGVMPKTLHVDVPSPHVDWSAGAVSLLTDPRPWPEHGGPRRAGVSSFGISGTNAH 451 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ P + ++A +A VPWV++ARS +AL QA RLL H+TAD + L Sbjct 452 VIVEQAPAAAETEAAPASSAMPDA--VVPWVVSARSAEALAGQARRLLDHVTADAQASPL 509 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVGWSLVSTR+VF+HRAVVVG +RG L GLAGLA+G P A VVGRAR+ GKTV VFPG Sbjct 510 DVGWSLVSTRAVFEHRAVVVGCERGALATGLAGLASGRPDAATVVGRARATGKTVLVFPG 569 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMGRQLY R+ VFARA DE VAV+D RL VR+VMWGAD LL+STEFAQPAL Sbjct 570 QGSQTLGMGRQLYERFVVFARALDEAVAVVDEHSRLPVREVMWGADPELLQSTEFAQPAL 629 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 FV +VALAAL + GV PD+VMGHSVGEIAAA VAG LSL DAAR+VAARG LM ALPAG Sbjct 630 FVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLPDAARLVAARGALMAALPAG 689 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAV A E +VAPL+ GV IAAVN P++VV+SGEQ AV V +RL G G RV RLAV Sbjct 690 GVMVAVTAGEAQVAPLVGGGVSIAAVNGPDAVVLSGEQEAVAAVAERLAGSGARVHRLAV 749 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LM+PM+ F+ A + R PRI LVSN+TGQLAG GYG+P YWVEHVR PV+ Sbjct 750 SHAFHSALMEPMLGGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGTPQYWVEHVRAPVQ 809 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEASV------------ALLARDRPEVESVLAGVGR 797 F GV AE GA F+E+GPGA L A+V A L +DRPE ES L G Sbjct 810 FLAGVRAAEQAGAGTFLELGPGAALTAAVDQSLSTEGATAIATLPKDRPETESALHAAGH 869 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIA----- 852 LF G +DW+ VFAGL RRVELPTY FAR+RFWLG G Sbjct 870 LFTRGHRLDWAGVFAGLPARRVELPTYAFARERFWLGGASLAGAPAGAAPVGGGTRAPEL 929 Query 853 --RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQ 910 RL +L E QR L ELVC HAA VLG IDP AF DLGFDS+ GVELRNRL Sbjct 930 AHRLHALPRDEQQRVLRELVCEHAAAVLGHPDGDAIDPHRAFADLGFDSLIGVELRNRLT 989 Query 911 MAIGLPGLSLPRTLIFDYPTASALAECL-GQLLGGQHESSDDESIWQLLKNIPIHQLRRT 969 G +L RTLIFDYPT +ALA+ L QLL + SDDE IW L+ IP+ +LRRT Sbjct 990 THT---GTALSRTLIFDYPTPTALADHLRRQLLHDEDPESDDERIWSALRRIPLRELRRT 1046 Query 970 GLLDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGLALDEDEND 1015 GLLDKLLLLAG PE + +SD IDSLSP+ALI +AL+ ++D Sbjct 1047 GLLDKLLLLAGIPETATTDPKISDADIDSLSPDALIAMALNSADDD 1092 >gi|308376786|ref|ZP_07440032.2| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu008] gi|308349885|gb|EFP38736.1| putative acyl transferase domain protein [Mycobacterium tuberculosis SUMu008] Length=449 Score = 882 bits (2280), Expect = 0.0, Method: Compositional matrix adjust. Identities = 448/449 (99%), Positives = 449/449 (100%), Gaps = 0/449 (0%) Query 569 LFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPA 628 +FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPA Sbjct 1 MFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPA 60 Query 629 GGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLA 688 GGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLA Sbjct 61 GGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLA 120 Query 689 VSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPV 748 VSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPV Sbjct 121 VSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPV 180 Query 749 RFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWS 808 RFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWS Sbjct 181 RFFDGVGLAESLGARVFVEVGPGAGLEASVALLARDRPEVESVLAGVGRLFAEGVAVDWS 240 Query 809 SVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVE 868 SVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVE Sbjct 241 SVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVE 300 Query 869 LVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDY 928 LVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDY Sbjct 301 LVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDY 360 Query 929 PTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAG 988 PTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAG Sbjct 361 PTASALAECLGQLLGGQHESSDDESIWQLLKNIPIHQLRRTGLLDKLLLLAGQPEESLAG 420 Query 989 RTVSDEVIDSLSPEALIGLALDEDENDIR 1017 RTVSDEVIDSLSPEALIGLALDEDENDIR Sbjct 421 RTVSDEVIDSLSPEALIGLALDEDENDIR 449 >gi|289757774|ref|ZP_06517152.1| polyketide synthase pks9 [Mycobacterium tuberculosis T85] gi|289713338|gb|EFD77350.1| polyketide synthase pks9 [Mycobacterium tuberculosis T85] Length=428 Score = 845 bits (2183), Expect = 0.0, Method: Compositional matrix adjust. Identities = 425/426 (99%), Positives = 426/426 (100%), Gaps = 0/426 (0%) Query 28 LRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQ 87 +RDGREAAGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQ Sbjct 1 MRDGREAAGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQ 60 Query 88 PIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSS 147 PIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSS Sbjct 61 PIAVYLGAMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSS 120 Query 148 LVAVHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVP 207 LVAVHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVP Sbjct 121 LVAVHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVP 180 Query 208 GDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGA 267 GDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGA Sbjct 181 GDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGA 240 Query 268 GVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAG 327 GVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAG Sbjct 241 GVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAG 300 Query 328 LLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 LLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN Sbjct 301 LLKAVLAIENAVIPPSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 360 Query 388 AHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLT 447 AHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLT Sbjct 361 AHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLT 420 Query 448 ALDVGW 453 ALDVGW Sbjct 421 ALDVGW 426 >gi|345011383|ref|YP_004813737.1| beta-ketoacyl synthase [Streptomyces violaceusniger Tu 4113] gi|344037732|gb|AEM83457.1| Beta-ketoacyl synthase [Streptomyces violaceusniger Tu 4113] Length=4516 Score = 822 bits (2124), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/974 (50%), Positives = 607/974 (63%), Gaps = 62/974 (6%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGREA--------------------AGSIDNVADFD 45 IA+IG+ACR P +P W LLR+G A G ++ A+FD Sbjct 12 IAVIGMACRVPGASTPDGFWQLLRNGESAITEIPADRYADELRDAGIRFGGFVETAAEFD 71 Query 46 ADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTL 105 +FF +SPREA AMDP+QRLALEL WE LE+A +VP L G V++GA+ DDYA L Sbjct 72 PEFFGISPREALAMDPQQRLALELCWEALENAGLVPAHLEGSRTGVFIGAIADDYATLVH 131 Query 106 AAD--RVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEA 163 + + H G +R IIANRVS+A GLRGPSV +D+GQSSSL AVHLACES+R GE Sbjct 132 RREPATITQHTLTGLNRGIIANRVSYALGLRGPSVAVDTGQSSSLAAVHLACESLRRGET 191 Query 164 PLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAAL 223 A+AGGV LNLA ++ + FGA+SP G ++ FD RA+GYV G+GGGLV+LK + A Sbjct 192 ETAVAGGVQLNLAPDSFIAASRFGALSPDGRSFTFDARANGYVRGEGGGLVVLKRLADAR 251 Query 224 DDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTG 283 DGD + +IRGS N G LT P+ GQ ++R A AGVD +V YVE HGTG Sbjct 252 RDGDPMLGVIRGSEANNDG-GGDSLTTPAAHGQEAMLRAAYERAGVDPARVQYVELHGTG 310 Query 284 TKIGDPIEARALGEIFAARQRR--PVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIP 341 TKIGDP+EA+ALG + + P+ VGS KTN+GH GAAGI GL+K +L++ + + Sbjct 311 TKIGDPVEAQALGAVLGTGRAHGAPLRVGSAKTNVGHLEGAAGITGLIKTLLSLAHRELF 370 Query 342 PSLNYV--GAAIDLDSLGLRVDTALTPW-PVADEPRRAGVSSFGMGGTNAHVILEQGPTQ 398 PSLNY AI LDSLGL V TAL PW P AD PR AGVSSFGMGGTN H++LEQ P + Sbjct 371 PSLNYETPNPAIPLDSLGLTVQTALAPWVPEADTPRLAGVSSFGMGGTNVHMVLEQAPAE 430 Query 399 SPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVST 458 P AA VPWVL+AR AL QA RL +++ A L +DV +SL Sbjct 431 DP------AAERPMDLDVVPWVLSARGEAALRAQARRLRSYVAARPELDPVDVSYSLALG 484 Query 459 RSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMG 518 RS F HRA VVG DR L+ GL LA G VV G G T F+F GQG+Q LGMG Sbjct 485 RSAFGHRAAVVGRDRDELLRGLDELATG-----VVPGTVAGRGGTAFLFTGQGAQRLGMG 539 Query 519 RQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAA 578 R+LY + VFA AFD V A LD L SVR+V++G DA L+ T F Q LF V+VAL Sbjct 540 RELYAEFPVFAEAFDAVCAELDRHLDGSVREVVFGGDAEALDRTVFTQTGLFAVEVALFR 599 Query 579 LLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAAS 638 L+ WGV PD V+GHSVGE+ AA+VAG SL DAA +V ARGRLMQALP GG MV++ A+ Sbjct 600 LVASWGVAPDFVVGHSVGELVAAHVAGVFSLEDAAALVGARGRLMQALPEGGAMVSLQAA 659 Query 639 EDEVAPLLT---EGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHS 695 E EV P L + V +AAVN P + VISGE++AV V + +G + +RL+VSHAFHS Sbjct 660 EAEVLPHLAGYEDRVSVAAVNGPAATVISGEESAVLAVAE---AVGGKSKRLSVSHAFHS 716 Query 696 VLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVG 755 LM+ M+ EF++V + APR+ +VSNVTG+LAG SP YWV HVR+ VRF DG+ Sbjct 717 PLMEGMLAEFAEVAGRIGYSAPRLVIVSNVTGELAGEEVCSPEYWVRHVRQAVRFGDGIR 776 Query 756 LAESLGARVFVEVGPGAGLEAS------------VALLARDRPEVESVLAGVGRLFAEGV 803 E G +VE+GP L A + LL +DR E E++L+GV +L A G Sbjct 777 FLEGQGVTRYVEIGPAGVLSAMGRDCVSEAAAAFIPLLRKDRAEAEALLSGVAQLHAHGG 836 Query 804 AVDWSSVFAGLGGRRVELPTYGFARQRFWL-GDNGELSVDQTGKDAGAIARLQSLA-PPE 861 VDW VFAG G RRVELPTY F RQR+WL D + TG+ +LA P E Sbjct 837 EVDWGRVFAGRGTRRVELPTYAFQRQRYWLDSDLPGIEEAATGEPLSWREEFAALADPAE 896 Query 862 LQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLP 921 +R +ELV H A VLG + +DPE F+DLGFDS+ VELR+ L A G L Sbjct 897 RERVALELVRTHTAWVLGSRGPETVDPETIFKDLGFDSLMSVELRDLLSTAT---GTRLA 953 Query 922 RTLIFDYPTASALA 935 T++FD+PT AL+ Sbjct 954 GTVLFDHPTPLALS 967 Score = 634 bits (1635), Expect = 3e-179, Method: Compositional matrix adjust. Identities = 385/886 (44%), Positives = 530/886 (60%), Gaps = 76/886 (8%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IAI+ ++CR P V P +LW+L+ DGR+ Sbjct 2909 IAIVAMSCRLPGGVRGPEELWELVADGRDVISAFPADRGWNVEELYDPNPDTPGRSYAKE 2968 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + FD +FF +SPREA AMDP+QRL LE +WE LE A + P T RG V++G Sbjct 2969 GGFLYDAYHFDPEFFGISPREALAMDPQQRLLLETSWEALERAGIDPHTTRGSTAGVFIG 3028 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 + DYA L + ++ + G + ++++ R++++ G GP++TID+ SSSLVA+H Sbjct 3029 STGQDYASGLGEIPEDMEGYLLTGKAASVVSGRIAYSLGWEGPALTIDTACSSSLVAIHQ 3088 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDG 210 A +++R GE +A+AGG + T L EF ++P G + AF DG G+G Sbjct 3089 AAQALRQGECSMALAGGTTM---MSTPSLFIEFSRQRGLAPDGRSKAFSSDTDGTSWGEG 3145 Query 211 GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVD 270 +VLL+ + A +G + A++RGSAV G S GLT P+ Q VIR+A++ AG+ Sbjct 3146 VSMVLLERLSDARANGHEVLALVRGSAVNQDGAS-NGLTAPNGPSQQRVIRQALANAGLS 3204 Query 271 CHQVHYVEAHGTGTKIGDPIEARALGEIFAA--RQRRPVSVGSVKTNIGHTGGAAGIAGL 328 +V VEAHGTGT +GDPIEA+A+ + RP+ +G++K+NIGHT GAAG AG+ Sbjct 3205 AAEVDAVEAHGTGTTLGDPIEAQAILATYGQGREAERPLWLGALKSNIGHTQGAAGGAGV 3264 Query 329 LKAVLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGT 386 +K V+A+ + ++P +L+ +D + + + T WP + RRAGVS+FG+ GT Sbjct 3265 IKMVMAMRHGLLPRTLHVKEPTPHVDWTTGAVELLTEARDWPTGERVRRAGVSAFGISGT 3324 Query 387 NAHVILEQGPTQ---SPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTAD 443 NAH+ILE+ P + PE SV VPW+++ R+ AL QA RL +++ A Sbjct 3325 NAHLILEEPPAEPAADPEPGPSVRTD------VVPWLVSGRTEVALRAQAERLRSYVAAR 3378 Query 444 DGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAG-EPGAGVVVGRARSVGK 502 L +DVG+SL RS F HRA VV DR L++GL LA G PG A G+ Sbjct 3379 PELDPVDVGYSLAQARSAFGHRAAVVCRDREELLSGLNQLATGITPGT-----VADEEGR 3433 Query 503 TVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLEST 562 T F+F GQG+Q GMGR+LY + VFA AFD V A LD L SVR+V++G DA L+ T Sbjct 3434 TAFLFTGQGAQRPGMGRELYTEFPVFAEAFDAVCAELDRHLDGSVREVVFGGDAEALDRT 3493 Query 563 EFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRL 622 F Q LF V+VAL L++ WG+ PD V+GHSVGE+ AA+VAG SL DAA +V ARGRL Sbjct 3494 VFTQTGLFAVEVALFRLIESWGLAPDYVVGHSVGELVAAHVAGVFSLEDAAALVGARGRL 3553 Query 623 MQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVISGEQAAVGVVVDRLVG 679 MQALP GG MV++ A+E EV P L + V +AAVN P + VISGE++AV V + Sbjct 3554 MQALPEGGAMVSLQAAEAEVLPHLAGYEDRVSVAAVNGPAATVISGEESAVLAVAE---A 3610 Query 680 LGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAY 739 +G + +RL+VSHAFHS LM+ M+ EF++V + APR+ +VSNVTG+LAG SP Y Sbjct 3611 VGVKSKRLSVSHAFHSPLMEGMLAEFAEVAGRIGYSAPRLVIVSNVTGELAGEEVCSPEY 3670 Query 740 WVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS------------VALLARDRPE 787 WV HVR+ VRF DG+ E G +VE+GP L A + LL +DR E Sbjct 3671 WVRHVRQAVRFGDGIRFLEGQGVTRYVEIGPAGVLSAMGRDCVSEAAAAFIPLLRKDRAE 3730 Query 788 VESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 E++L+GV +L A G VDW VFAG G RRVELPTY F RQR+W Sbjct 3731 AEALLSGVAQLHAHGGEVDWGRVFAGRGTRRVELPTYAFQRQRYWF 3776 Score = 530 bits (1364), Expect = 8e-148, Method: Compositional matrix adjust. Identities = 358/898 (40%), Positives = 487/898 (55%), Gaps = 81/898 (9%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IAI+ ++CR P V +P LW LL +GR+A Sbjct 1000 IAIVAMSCRLPGGVRTPEQLWQLLGEGRDAIAGFPANRGWDLEGLYDPDPARHGTSYVRE 1059 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + FD FF +SPREA AMDP+QRL LE WE E A + P TL+G V++G Sbjct 1060 GGFLYEADQFDPAFFGISPREAQAMDPQQRLLLETAWEAFERAGIDPATLKGSDAGVFVG 1119 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 M DY + A++ + + G + ++ + R+++ +GL GP+VT+D+ SSSLVA+H+ Sbjct 1120 TMPQDYGPRMDEASEGFEGYLLTGGTTSVASGRIAYTWGLEGPAVTVDTACSSSLVALHM 1179 Query 154 ACESVRTGEAPLAIAGG--------VHLNLARETAMLEQEFGAVSPSGHTYAFDERADGY 205 A S+R GE LA+AGG + + L+R+ A+ SP G AF ADG Sbjct 1180 AVRSLREGECSLALAGGATVMSSPGIFVELSRQKAL--------SPDGRCKAFSSDADGT 1231 Query 206 VPGDGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMS 265 G+G G+VLL+ + A +G R+ A++RGSA G S GLT PS Q VIR+A++ Sbjct 1232 GWGEGVGMVLLERLSDARRNGHRVLALVRGSATNQDGAS-NGLTAPSGPAQQRVIRQALA 1290 Query 266 GAGVDCHQVHYVEAHGTGTKIGDPIEARALGEIFAAR--QRRPVSVGSVKTNIGHTGGAA 323 AG+ V VEAHGTGT +GDPIEA AL + + RP+ +GS+K+N+GH AA Sbjct 1291 DAGLTTADVDAVEAHGTGTSLGDPIEAGALLATYGQDRPEDRPLWLGSLKSNVGHPQAAA 1350 Query 324 GIAGLLKAVLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVAD--EPRRAGVS 379 G+AG++K V+A+ + +P +L+ + +D S G+ + T PWP + PRRAGVS Sbjct 1351 GVAGVIKMVMALRHGTLPKTLHVHEPSPHVDWSSGGVELLTEARPWPEPETARPRRAGVS 1410 Query 380 SFGMGGTNAHVILEQGPTQSPEIV--ESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLL 437 SFG+ GTNAH ILEQ P + P++ E A PV +PWVL+ R+ QAL +A +L Sbjct 1411 SFGISGTNAHAILEQAPAE-PDVAAQEKARPAAPGLPV-LPWVLSGRTEQALRTRAEQLR 1468 Query 438 AHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRA 497 HL G +G +L +TR+ F HRAVV+G DR RL+ GL LA G P + VV G A Sbjct 1469 DHLADHPGTDLAALGRALATTRTAFGHRAVVLGRDRERLLDGLGALAQGTPASHVVQGTA 1528 Query 498 RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD-A 556 K VFVFPGQGSQW+GM L+ VFA + L+ L S+R+V+ G A Sbjct 1529 GGRRKAVFVFPGQGSQWIGMALPLWNASPVFAERLEACADALEPFLDWSLREVLRGEPGA 1588 Query 557 GLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVV 616 L + QPALF V V+LAAL + +GV V+GHS GEIAAAYVAG LSL DAA+VV Sbjct 1589 PSLSRIDVVQPALFAVMVSLAALWRSYGVESAAVVGHSQGEIAAAYVAGGLSLEDAAKVV 1648 Query 617 AARGRLMQALPAGGVMVAVAASEDEVAPLL---TEGVCIAAVNAPESVVISGEQAAVGVV 673 A R + L G M++V AS + VA L +E + IAAVN+P +V +SG+ A+ Sbjct 1649 ARRSQAWAELSGKGGMLSVLASAETVAERLRPWSERLGIAAVNSPATVTVSGDPEALDAF 1708 Query 674 VDRLVGLGRRVRRL-AVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGA 732 + L G + RR+ V A HS +D + E + +A V RA RI S VTG Sbjct 1709 MAELAADGVKSRRVPGVDTAGHSPQVDGLRERLLRDVAGVRPRASRIAYYSTVTGGPLAT 1768 Query 733 GYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGP--------------GAGLEASV 778 YW ++R+PV F + G F+E P G A V Sbjct 1769 TELDTDYWYRNMREPVDFERATRALLADGHTAFIECAPHPMLAMSLQQTIEDAGGSAAVV 1828 Query 779 ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGR---RVELPTYGFARQRFWL 833 L RD + E + +GV W +VF G GR VELPTY F RQR+WL Sbjct 1829 GTLRRDEGDPERFAGSFAEAYVQGVEPSWDAVFGGGPGRGAPDVELPTYPFQRQRYWL 1886 Score = 73.2 bits (178), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/130 (42%), Positives = 71/130 (55%), Gaps = 15/130 (11%) Query 821 LPTYGFARQRFWLGDNGEL---------SVDQTGKDAGAIARLQSLAP---PELQRQLVE 868 +P + AR R +G+ E+ + D TG D A L+SLA +L R L + Sbjct 4304 VPGFTAARPRPLIGELPEVRDALATTAAAPDGTGPDGVADTFLESLAGLSGEDLGRALRD 4363 Query 869 LVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDY 928 LV AA VLG SS + F++LGFDS++ VELRNRL + GL LP TL+FDY Sbjct 4364 LVHAQAAAVLGHSSSDAVAGGRPFKELGFDSLTAVELRNRLAT---VTGLDLPATLVFDY 4420 Query 929 PTASALAECL 938 P + LAE L Sbjct 4421 PAPAPLAEYL 4430 Score = 70.1 bits (170), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 38/73 (53%), Positives = 50/73 (69%), Gaps = 3/73 (4%) Query 866 LVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLI 925 L++LV HAA VLG + DI+ AF+++GFDS++ VELRNRL A GL LP TL+ Sbjct 2814 LLDLVREHAAGVLGLAAPEDIEATRAFREVGFDSLTAVELRNRLGAAT---GLRLPTTLL 2870 Query 926 FDYPTASALAECL 938 FDYPT + L + L Sbjct 2871 FDYPTPAVLVDQL 2883 >gi|289568319|ref|ZP_06448546.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T17] gi|289752434|ref|ZP_06511812.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis EAS054] gi|289542072|gb|EFD45721.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T17] gi|289693021|gb|EFD60450.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis EAS054] Length=1402 Score = 817 bits (2111), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|15839791|ref|NP_334828.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|13879921|gb|AAK44642.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|323721076|gb|EGB30138.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CDC1551A] Length=1402 Score = 817 bits (2111), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|148821601|ref|YP_001286355.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis F11] gi|253797328|ref|YP_003030329.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis KZN 1435] gi|289552654|ref|ZP_06441864.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis KZN 605] 9 more sequence titles Length=1402 Score = 817 bits (2110), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|289744101|ref|ZP_06503479.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis 02_1987] gi|298523881|ref|ZP_07011290.1| membrane bound polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|289684629|gb|EFD52117.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis 02_1987] gi|298493675|gb|EFI28969.1| membrane bound polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=1389 Score = 817 bits (2110), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 96 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 155 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 156 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 215 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 216 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 275 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 276 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 335 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 336 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 394 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 395 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 454 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 455 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 514 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 515 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 574 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 575 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 634 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 635 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 694 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 695 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 754 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 755 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 814 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 815 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 874 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 875 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 934 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 935 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 994 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 995 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRLT---A 1051 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1052 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1082 >gi|15607546|ref|NP_214919.1| membrane bound polyketide synthase [Mycobacterium tuberculosis H37Rv] gi|148660170|ref|YP_001281693.1| membrane bound polyketide synthase Pks6 [Mycobacterium tuberculosis H37Ra] gi|306774499|ref|ZP_07412836.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis SUMu001] 9 more sequence titles Length=1402 Score = 817 bits (2110), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|289572990|ref|ZP_06453217.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis K85] gi|339630474|ref|YP_004722116.1| polyketide synthase [Mycobacterium africanum GM041182] gi|289537421|gb|EFD41999.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis K85] gi|339329830|emb|CCC25479.1| putative membrane bound polyketide synthase PKS6 [Mycobacterium africanum GM041182] Length=1402 Score = 816 bits (2109), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|289441784|ref|ZP_06431528.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T46] gi|289414703|gb|EFD11943.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis T46] Length=1302 Score = 816 bits (2109), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|344218221|gb|AEM98851.1| membrane bound polyketide synthase [Mycobacterium tuberculosis CTRI-2] Length=1402 Score = 816 bits (2107), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 D+VAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DDVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|254363369|ref|ZP_04979415.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis str. Haarlem] gi|134148883|gb|EBA40928.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis str. Haarlem] Length=1402 Score = 815 bits (2106), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/991 (49%), Positives = 614/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L +DVG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 + WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 VMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|289445944|ref|ZP_06435688.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CPHL_A] gi|289418902|gb|EFD16103.1| membrane bound polyketide synthase pks6 [Mycobacterium tuberculosis CPHL_A] Length=1402 Score = 814 bits (2102), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/991 (49%), Positives = 613/991 (62%), Gaps = 55/991 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQGPTQS 399 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVG 527 Query 400 PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTR 459 + V A G + V WV++ ++ AL QAGRL ++ A L + VG+SLVSTR Sbjct 528 ADTVSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRARPALDVVGVGYSLVSTR 587 Query 460 SVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGR 519 SVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 588 SVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMGS 647 Query 520 QLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAAL 579 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL L Sbjct 648 ELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYRL 707 Query 580 LQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASE 639 L WGV P LV+GHSVGE+AAA+VAGAL L DAA +VAARGRLMQALPAGG M AV A E Sbjct 708 LMSWGVRPGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQARE 767 Query 640 DEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMD 699 DEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM+ Sbjct 768 DEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALME 827 Query 700 PMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAES 759 PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 828 PMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAHC 887 Query 760 LGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVDW 807 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +DW Sbjct 888 AGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDW 947 Query 808 SSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIARL 854 +SVF+G +RVELPTY F Q+FWL G++ G + +G ARL Sbjct 948 ASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAARL 1007 Query 855 QSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIG 914 + E +E+VC HAA VLGR + +D AF D GF+S+S VELRNRL Sbjct 1008 AGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAVELRNRL---TA 1064 Query 915 LPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 + ++LP T IFD+PT + LA+ L + G Sbjct 1065 VTAVTLPATAIFDHPTPTELAQYLITQIDGH 1095 >gi|340625431|ref|YP_004743883.1| polyketide synthase pks6 [Mycobacterium canettii CIPT 140010059] gi|340003621|emb|CCC42743.1| polyketide synthase pks6 [Mycobacterium canettii CIPT 140010059] Length=2410 Score = 814 bits (2102), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/996 (49%), Positives = 614/996 (62%), Gaps = 59/996 (5%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGR------------------EAAGSIDNVADFDA 46 +A+IG+ CRFP + P LWD L + + E+ G + +VA FD Sbjct 109 VAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRGFTNAGTFAESGGFLKDVAGFDN 168 Query 47 DFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVLTLA 106 FF++ P EA MDP+QRL LE++WE LE A ++PE+LR V++G + DY L A Sbjct 169 RFFDIPPDEALRMDPQQRLLLEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSA 228 Query 107 ADRVDHHAF--AGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAP 164 + + + G S +IIANR+S+ ++GPS+ ID+ SSSLVAVHLAC S+ T + Sbjct 229 SAQQKSTIWDNTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD 288 Query 165 LAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALD 224 +A+ GG ++ ++ E +E G +S +G +AFD+ ADG V G+G G+++L+ + A Sbjct 289 IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVIVLQRLSDARL 348 Query 225 DGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGT 284 +G RI AI+ GSAV G S G+ P+ + Q+ V+ A A VD ++ YVEAHGTGT Sbjct 349 EGRRILAILTGSAVNQDGKS-NGIMAPNPSAQIGVLENACKSARVDPLEIGYVEAHGTGT 407 Query 285 KIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPP 342 +GD IEA ALG +F ++ P+ +GS+K NIGH GAAGIAGL+KAVL +E + P Sbjct 408 SLGDRIEAHALGMVFGRKRPGSGPLMIGSIKPNIGHLEGAAGIAGLIKAVLMVERGSLLP 467 Query 343 SLNYV--GAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAHVILEQG-PTQ 398 S + AI LGLRV L WPV A PRRAGVSSFG GGTNAHVI+E+ P + Sbjct 468 SGGFTEPNPAIPFTELGLRVVDELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAFPVE 527 Query 399 SPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVST 458 S + +G V WV++ ++ AL QAGRL ++ A L +DVG+SLVST Sbjct 528 SDGVCAGADGSGGGV---VAWVISGKTASALAAQAGRLGRYVRARPALDVVDVGYSLVST 584 Query 459 RSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMG 518 RSVFDHRAVVVG R L+AGLAG+ AG P AGVV G + GKT FVF GQGSQWLGMG Sbjct 585 RSVFDHRAVVVGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFAGQGSQWLGMG 644 Query 519 RQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAA 578 +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPALF V+VAL Sbjct 645 SELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPALFAVEVALYR 704 Query 579 LLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAAS 638 LL WGV P LV+GHSVGE+AAA++AGAL L DAA +VAARGRLMQALPAGG M AV A Sbjct 705 LLMSWGVRPGLVLGHSVGELAAAHIAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQAR 764 Query 639 EDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLM 698 EDEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLAVSHAFHS LM Sbjct 765 EDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLAVSHAFHSALM 824 Query 699 DPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAE 758 +PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R VRF D V A Sbjct 825 EPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVVRFGDSVRSAH 884 Query 759 SLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAEGVAVD 806 GA F+EVGPG GL + SV L +DRPE SV+ + F G+ +D Sbjct 885 CAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLD 944 Query 807 WSSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD----AGAIAR 853 W+SVF+G +RVELPTY F Q+FWL G++ G + +G AR Sbjct 945 WASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAELLASSGFAAR 1004 Query 854 LQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAI 913 L + E +E+VC HAA VLGR + +D AF D G +S+S VELRNRL+ Sbjct 1005 LAGRSADEQLAAAIEVVCEHAAAVLGRGDAASVDAAQAFTDSGLNSLSAVELRNRLK--- 1061 Query 914 GLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESS 949 + G +L T +FDYPT + LA L L G S+ Sbjct 1062 AVTGATLSATAVFDYPTPTDLARYLVSHLDGAGRSA 1097 Score = 768 bits (1983), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/995 (47%), Positives = 602/995 (61%), Gaps = 72/995 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IA++G+ CR+P VV+ DLW L+ GR+ Sbjct 1112 IAVVGMGCRYPGGVVTAEDLWQLVASGRDVISEFPADRGWDVEGLYDADPDVLGKCYTRQ 1171 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G +D+VA+FDA FF +SP EA AMDP+QRL LE++WE LE+A + P LRG V++G Sbjct 1172 GGFVDDVANFDAGFFGISPGEALAMDPQQRLLLEISWEALENAGIDPLALRGSATGVFVG 1231 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 D Y V T + +A G ++ + R++++ GL GP++++D+ SSSLVA+HLA Sbjct 1232 IYGDGYGVGT---SQAQWYADTGHITSVASGRIAYSLGLTGPALSVDTACSSSLVALHLA 1288 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLV 214 S+R GE LA+AGG + + + +S G AF + ADG +G G++ Sbjct 1289 ANSLRAGECDLALAGGSTVLVTPSIFLGFSRQRGLSVDGRCKAFADAADGTGFSEGAGVL 1348 Query 215 LLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQV 274 +++ + A G R+ A++ GSAV G S GLT PS Q VI A++ AG+ V Sbjct 1349 VMQRLGDARRAGRRVLAVLAGSAVNQDGAS-NGLTAPSGPAQQQVIAAALADAGITGADV 1407 Query 275 HYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKAV 332 VEAHGTGT++GDPIEA+AL + P+ +GS+K+NIGH+ AAG+AG++K + Sbjct 1408 DVVEAHGTGTRLGDPIEAQALLATYGQHHTPDAPLWLGSIKSNIGHSQAAAGVAGVIKMI 1467 Query 333 LAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPV-ADEPRRAGVSSFGMGGTNAH 389 A+ + ++P +L + + +D S +R+ T WPV A RRAGVSSFG+ GTNAH Sbjct 1468 EAMRHQMLPATLHVDRPSSHVDWSSGTVRLLTEAKEWPVVAGRLRRAGVSSFGVSGTNAH 1527 Query 390 VILEQG-PTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTA 448 VI+E+ P S + +G V WV++ ++ AL QAGRL ++ A L Sbjct 1528 VIVEEAFPVDSDGVCAGADGSGGGV---VAWVISGKTASALAAQAGRLGRYVRARPALDV 1584 Query 449 LDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFP 508 +DVG+SLVSTRSVFDHRAVV+G R L+AGLAG+ AG P AGVV G + GKT FVF Sbjct 1585 VDVGYSLVSTRSVFDHRAVVIGQTRDELLAGLAGVVAGRPEAGVVCGVGKPAGKTAFVFA 1644 Query 509 GQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPA 568 GQGSQWLGMG +LY Y VFA A D VV LD LR +R V+WG D LL +TEFAQPA Sbjct 1645 GQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHLRYPLRDVIWGHDQDLLNTTEFAQPA 1704 Query 569 LFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPA 628 LF V+VAL LL WGV P LV+GHSVGE+AAA++AGAL L DAA +VAARGRLMQALPA Sbjct 1705 LFAVEVALYRLLMSWGVRPGLVLGHSVGELAAAHIAGALCLPDAAMLVAARGRLMQALPA 1764 Query 629 GGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLA 688 GG M AV A EDEVAP+L V IAAVN P SVVISG AV + DRL G GRRV RLA Sbjct 1765 GGAMFAVQAREDEVAPMLGHDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRRVHRLA 1824 Query 689 VSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPV 748 VSHAFHS LM+PM+ EF+ V A++ V P I ++SNVTGQL + S YW H+R V Sbjct 1825 VSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVADDFASADYWARHIRAVV 1884 Query 749 RFFDGVGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVG 796 RF D V A GA F+EVGPG GL + SV L +DRPE SV+ Sbjct 1885 RFGDSVRSAHCAGASRFIEVGPGGGLTSLIEASLADAQIVSVPTLRKDRPEPVSVMTAAA 1944 Query 797 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGD---------NGELSVDQTGKD 847 + F G+ +DW+SVF+G +RVELPTY F Q+FWL G++ G + Sbjct 1945 QGFVSGMGLDWASVFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPTAAGQIGASDGGAE 2004 Query 848 ----AGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGV 903 +G ARL + E +E+VC HAA VLGR + +D AF D GF+S+S V Sbjct 2005 LLASSGFAARLAGRSADEQLAAAIEVVCEHAAAVLGRDGAAGLDAGQAFADSGFNSLSAV 2064 Query 904 ELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL 938 ELRNRL + ++LP T IFD+PT + LA+ L Sbjct 2065 ELRNRL---TAVTAVTLPATAIFDHPTPTELAQYL 2096 >gi|302542518|ref|ZP_07294860.1| modular polyketide synthase [Streptomyces hygroscopicus ATCC 53653] gi|302460136|gb|EFL23229.1| modular polyketide synthase [Streptomyces himastatinicus ATCC 53653] Length=2116 Score = 811 bits (2096), Expect = 0.0, Method: Compositional matrix adjust. Identities = 473/998 (48%), Positives = 610/998 (62%), Gaps = 65/998 (6%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGREAAGS---------------------------I 38 IA+IG++CRF V +P D W LLR+G A + Sbjct 9 IAVIGMSCRFSGVANPADFWQLLRNGTGAVSGMPRQRMNVEHSRQGETGGGESIARGSFL 68 Query 39 DNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPE--------TLRGQPIA 90 + V FD F +S REA+AMDP+QRL LEL WE LED+ + P +G Sbjct 69 ERVDQFDPGLFGISAREAAAMDPQQRLMLELAWEALEDSGIPPSGRPSERSSASKGDVTG 128 Query 91 VYLGAMNDDYAVLT--LAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSL 148 V++GAM DDYA LT A V HA G +R+IIANRVS+A GLRGPS+T+D+GQSSSL Sbjct 129 VFVGAMWDDYATLTHRQGASAVGQHAMTGLARSIIANRVSYALGLRGPSMTVDTGQSSSL 188 Query 149 VAVHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPG 208 VAVH A +++R GE +A+AGGV+L LA E++ ++FG +SP G FD RA+GYV G Sbjct 189 VAVHQAVQALRAGECSVALAGGVNLVLAPESSDRSEKFGGLSPDGECRTFDARANGYVRG 248 Query 209 DGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAG 268 +GGGLV+LK + A DGDRI +IRGSAV N G GL P Q +++ A AG Sbjct 249 EGGGLVVLKELSRARADGDRILCVIRGSAVNNDG-GGEGLVAPHRIAQEELLGLACQRAG 307 Query 269 VDCHQVHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIA 326 V+ V YVE HGTGT++GD +EA ALG + + P+ VGSVKTN+GH GAAGIA Sbjct 308 VEPAAVQYVELHGTGTRLGDHVEATALGAVMGNGRPADDPLRVGSVKTNLGHLEGAAGIA 367 Query 327 GLLKAVLAIENAVIPPSLNYVGAAID--LDSLGLRVDTALTPWPVADEPRRAGVSSFGMG 384 GL+K +LAI N IP SLN+ D LD+L LRV T+L PWP D AGVS+FGMG Sbjct 368 GLIKTILAIRNRRIPASLNFRDPRPDIPLDALRLRVQTSLEPWPHEDAQLLAGVSAFGMG 427 Query 385 GTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADD 444 GTNAHV+LE+ P +P A S P VPWV++ R AL QA RLLA + D Sbjct 428 GTNAHVVLEEAPAVTPR-------AASVEPAVVPWVVSGRGEAALREQAERLLARVEGDT 480 Query 445 GLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTV 504 GL+ LDVGWSL S R+ + RAV+ R L+ L LA GE +G+V G A GK Sbjct 481 GLSPLDVGWSLASGRAELERRAVLTATGRDELLRALGALARGETASGLVEGTAGD-GKVA 539 Query 505 FVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEF 564 F+F GQGSQ LGMGR+LY Y VFA A DEV A LD L ++ V++G DA LL+ T F Sbjct 540 FLFTGQGSQRLGMGRELYDTYPVFAEALDEVCAHLDPHLERPLKGVLFGEDASLLDQTGF 599 Query 565 AQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQ 624 QPALF V+VAL L++ WG+ PD + GHS+GE+ AA+VAG L+L DA+ +VAARGRLMQ Sbjct 600 TQPALFAVEVALFRLVEAWGLRPDFLSGHSIGELTAAHVAGVLTLADASTLVAARGRLMQ 659 Query 625 ALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRV 684 ALP GG M+AV A+E EVAPLLT+ V IAA+N P SVVI+G++ + GR+ Sbjct 660 ALPTGGAMIAVQATEAEVAPLLTDRVGIAALNGPTSVVIAGDEDVALEIAVSFEAQGRKT 719 Query 685 RRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGA-GYGSPAYWVEH 743 +RLAVSHAFHS MD M++ F +V + AP I +VSN+TG + A +P +WV H Sbjct 720 KRLAVSHAFHSPRMDGMLDAFREVAQGLSYEAPSIPVVSNLTGDVVSAEEITTPDFWVRH 779 Query 744 VRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----------VALLARDRPEVESVLA 793 VR+ VRF DG+ + G VFVEVGPG L + V +L RPE + + Sbjct 780 VREAVRFSDGISALHAAGVGVFVEVGPGGALSSMGAETVSDAVFVPVLRAGRPEERAFVG 839 Query 794 GVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIA- 852 GV R + G VDW F G G RV+LPTY F RQR+W+G+ + D + +A Sbjct 840 GVARAWVHGAPVDWRRAFEGTGASRVDLPTYAFQRQRYWIGETTRTAEDAAPERGSVLAG 899 Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 R+ + E +R++ LV A+VL S+ +D + F+DLGFDS++ VELRN L A Sbjct 900 RIAAAGDQERRREVRALVLAQTAVVLEYASADMVDADRTFKDLGFDSLTAVELRNLLNTA 959 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSD 950 GL+LP +L+FDYPT +AL L LL G + +D Sbjct 960 T---GLTLPSSLLFDYPTPTALVRHLVSLLTGAPQDAD 994 Score = 508 bits (1309), Expect = 2e-141, Method: Compositional matrix adjust. Identities = 363/898 (41%), Positives = 494/898 (56%), Gaps = 93/898 (10%) Query 6 IAIIGLACRFPTVV-SPGDLWDLLRDGREA------------------------------ 34 IAI+G+ CR P SP +LW L+ G +A Sbjct 1009 IAIVGMGCRLPGGAGSPEELWRLVTSGGDAISDFPADRGWDLAALYDEDPERSGTSYVRE 1068 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + A+FD FF +SPREA AMDP+QRL LE WE E A + P ++RG V+ G Sbjct 1069 GGFLHDAAEFDPAFFGISPREALAMDPQQRLLLETAWEAFERAGIDPSSVRGSRAGVFAG 1128 Query 95 AMNDDY-AVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 AM+ DY A L AA+ +D + G + +I+ R+++ GL GP+VT+D+ SSSLVA+H Sbjct 1129 AMSQDYGAPLHQAAEGLDGYLITGKAAGVISGRLAYFLGLEGPAVTVDTACSSSLVALHQ 1188 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDG 210 A +S+R GE LA+AGGV + T + EF ++ G + AF ADG +G Sbjct 1189 AAQSLRAGECSLALAGGVTVM---ATPGMFTEFSRQRGLAVDGRSKAFAAAADGTSWSEG 1245 Query 211 GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVD 270 G++LL+ + A +G + A+IRGSAV G S GLT P+ Q VIR+A++ A + Sbjct 1246 AGMLLLERLSDARRNGHTVLAVIRGSAVNQDGAS-NGLTAPNGPSQQRVIRQALANARLT 1304 Query 271 CHQVHYVEAHGTGTKIGDPIEARALGEIFAA--RQRRPVSVGSVKTNIGHTGGAAGIAGL 328 +V VEAHGTGT +GDPIEA+AL + + +P+ +GS+K+NIGHT AAG+AG+ Sbjct 1305 AAEVDAVEAHGTGTTLGDPIEAQALIATYGQGRAEGQPLWLGSLKSNIGHTQAAAGVAGV 1364 Query 329 LKAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVA-DEPRRAGVSSFGMGG 385 +K V A+ + V+P SL + +D S +++ T WP A D PRRAGVSSFG+ G Sbjct 1365 IKMVEAMRHGVLPRSLHVDEPTPQVDWSSGAVQLLTEAREWPEAEDRPRRAGVSSFGISG 1424 Query 386 TNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDG 445 TNAH+ILEQ E+ A P VPWVL+ R P+AL QA RLL+ + D G Sbjct 1425 TNAHLILEQ-------APEAQPAPAPAVPAVVPWVLSGRGPEALRGQAARLLSRVEGDGG 1477 Query 446 LTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRA----RSVG 501 L+ +DVGWSL S R+ F++RAV +G +AGLA LA GE G+V G A R+ Sbjct 1478 LSPVDVGWSLASGRAAFENRAVALG------VAGLAALARGEDTPGLVTGPADGVTRAGE 1531 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFA-------RAFDEVVAVLDGQLRLSVRQVMWGA 554 + VFVFPGQGSQW GM +L VFA RA E V D L +RQ Sbjct 1532 RVVFVFPGQGSQWTGMAVELLDTSPVFAARMAECGRALAEYV---DWDLEGVLRQA---P 1585 Query 555 DAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAAR 614 A LE + QPALF V V+LAAL + +GV P V+GHS GEIAAA GAL+L DAAR Sbjct 1586 GAPTLERVDVVQPALFAVMVSLAALWRSYGVEPSAVVGHSQGEIAAACAVGALTLRDAAR 1645 Query 615 VVAARGRLMQALPAG-GVMVAVAASEDEVAPLLTEG---VCIAAVNAPESVVISGEQAAV 670 V A R + + AG G MV++A + ++ + + + +A VN P SVV++G+ A+ Sbjct 1646 VAALRSQAIAEELAGLGGMVSLALTAEQATERIADWSGRLSLATVNGPTSVVVAGDVDAL 1705 Query 671 GVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLA 730 ++ G R RR+AV +A HS ++ + E+ ++VLA + + S VTG L Sbjct 1706 DELLAACEADGVRARRIAVDYASHSTHVEAIEEKLARVLAGIAPEPSPVPFYSTVTGGLL 1765 Query 731 GAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGP---------------GAGLE 775 YW ++R+ VRF + VG G VFVEV GA Sbjct 1766 DTTALDSGYWYRNLRQTVRFEETVGAVLEAGDAVFVEVSAHPVLAAAVQETAEARGAEQS 1825 Query 776 ASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 A V L RD E A + + GV VDW+ F G RRV+LPTY F RQR+WL Sbjct 1826 AVVGSLRRDEGGPERFAASLAEAWVRGVRVDWTRAFEGASARRVDLPTYAFQRQRYWL 1883 >gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Mycobacterium marinum M] gi|183175812|gb|ACC40922.1| polyketide synthase, Pks8 [Mycobacterium marinum M] Length=2114 Score = 803 bits (2073), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/884 (53%), Positives = 590/884 (67%), Gaps = 57/884 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 +A++G+ CR+P SP LW++L GR+A Sbjct 36 VALVGMGCRYPGGADSPESLWEMLTQGRDAVSEFPSDRGWDIDAMFDPDPDARGKTYTRR 95 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + DFDA FF + P EA AMDP+QRL LE++WE LE + + P TLRG V++G Sbjct 96 GGFLADAGDFDAGFFGVGPNEALAMDPQQRLMLEVSWEALERSGIDPTTLRGSATGVFVG 155 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y ++ + G++ ++ + RV++ GL GP+V++D+ SSSLVA+HLA Sbjct 156 VIHAGYG--GEVKGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLA 213 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+ E LA+ GGV + +A A +E A++ G A+ ADG +G G+ Sbjct 214 AQSLRSRECDLALVGGVTV-MATPAAFVEFSRQRALAADGLCKAYAGAADGTTWSEGAGV 272 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++++ + A G + A++RGSAV G S GLT P+ Q VIR A++ A + Sbjct 273 LVVERLADAQRLGHPVLAVVRGSAVNQDGAS-NGLTAPNGPSQQRVIRAALASARLGVAD 331 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 V VE HGTGT +GDPIEA+A+ + + P+ +GS+K+NIGHT AAG+AGL+K VL Sbjct 332 VDVVEGHGTGTVLGDPIEAQAILATYGQDRTEPLWLGSIKSNIGHTSAAAGVAGLIKMVL 391 Query 334 AIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVI 391 A+++ V+P +L + +D + + + T PWP PRRAGVSSFG+ GTNAHVI Sbjct 392 AMQHGVLPQTLHVDVPTPHVDWSAGAVSLLTESRPWPDLGRPRRAGVSSFGISGTNAHVI 451 Query 392 LEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDV 451 LEQ PT ++ E AP VPWVL+ARS AL NQA RLL+ L +DV Sbjct 452 LEQAPTAEHDLAEP----DRGAPT-VPWVLSARSAPALANQAQRLLSWAEEHPDLDPVDV 506 Query 452 GWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQG 511 GWSL +TRS+F+HRAVVVG DR +LM GLAG+ AGEPGAGVVVGRARS GKTVFVFPGQG Sbjct 507 GWSLAATRSLFEHRAVVVGTDRTQLMDGLAGVVAGEPGAGVVVGRARSTGKTVFVFPGQG 566 Query 512 SQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFV 571 +Q+LGMGR LY R+S F+ AFD A LD LRL +RQVMWG D GLLESTEFAQPALF Sbjct 567 AQYLGMGRVLYERFSAFSTAFDAAAAELDAHLRLPLRQVMWGTDEGLLESTEFAQPALFA 626 Query 572 VQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGV 631 V+VALAALL GV+PDLV+GHSVGEI+AA+VAG LSL DAAR+VAARGRLM L AGG Sbjct 627 VEVALAALLSQLGVVPDLVLGHSVGEISAAHVAGVLSLPDAARLVAARGRLMAGLAAGGA 686 Query 632 MVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSH 691 MVAVAASE EV PLL GV +AAVN P+SVVISG +AAVG VVDR+ LGRR RLAVSH Sbjct 687 MVAVAASEQEVTPLLGSGVAVAAVNGPDSVVISGPEAAVGEVVDRIAALGRRTHRLAVSH 746 Query 692 AFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFF 751 AFHS LMDPM+ +F++VL V PRI LVSNVTGQLA AGYGS AYWVEHVRKPVRF Sbjct 747 AFHSELMDPMLPDFAEVLKGVSASQPRISLVSNVTGQLAEAGYGSAAYWVEHVRKPVRFA 806 Query 752 DGVGLAESLGARVFVEVGPGAGLEA-----------SVALLARDRPEVESVLAGVGRLFA 800 D V LAESLGA FVEVGP GL A +V LL +DRPE +++L G+G+LFA Sbjct 807 DSVALAESLGAAAFVEVGPSGGLTALVEQSLTRETPAVPLLIKDRPENDALLLGLGQLFA 866 Query 801 EGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQT 844 +G A+DW FAGLG +R +LPTYGF R+R+WL EL VDQT Sbjct 867 DGRALDWREAFAGLGAQRTDLPTYGFVRRRYWL---KELGVDQT 907 Score = 97.8 bits (242), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 53/111 (48%), Positives = 72/111 (65%), Gaps = 4/111 (3%) Query 842 DQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMS 901 D + I+RL +L+P + R+LV+++C +AA VLG +S DID FQDLGFDS++ Sbjct 1931 DNSASMTALISRLHTLSPEQRSRELVDMICTNAATVLG-NASVDIDANKPFQDLGFDSLT 1989 Query 902 GVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDE 952 VELRNRL+ + GL+L TLIFDYPT +ALAE L L ++ DE Sbjct 1990 AVELRNRLKSST---GLTLSPTLIFDYPTPAALAEHLSTQLSSLSPAAADE 2037 >gi|157884996|gb|ABV91286.1| type I modular polyketide synthase [Streptomyces griseochromogenes] Length=9528 Score = 802 bits (2071), Expect = 0.0, Method: Compositional matrix adjust. Identities = 490/969 (51%), Positives = 600/969 (62%), Gaps = 65/969 (6%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGREA-----------------------AGSIDNVA 42 +A++GL+CR P + W+LLR G G + V Sbjct 10 VAVVGLSCRLPHAENLDAFWELLRSGASGVTEVGDDRWPGQGDPARPAVVRHGGFLPQVD 69 Query 43 DFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAV 102 FD FF +SPREA MDP+QRLALEL+WE LE A +VP LRG+P+ VY+G M DDYA Sbjct 70 TFDPGFFGISPREAVEMDPQQRLALELSWEALEHAGIVPGALRGEPVPVYVGVMADDYAK 129 Query 103 LTLA--ADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRT 160 L LA D D +A AGT RA+IANR+S G++G S+ +D+GQSSSLVAVHLACE++ + Sbjct 130 LRLADAGDDPDPYAQAGTQRALIANRISHFLGVQGESMAVDTGQSSSLVAVHLACEALLS 189 Query 161 GEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQ 220 G A A+AGGV LNL ETA++ + G +S G Y FD RADGYV G+GGG V+LK + Sbjct 190 GRATAALAGGVQLNLLEETALMAAKLGTLSADGQCYTFDARADGYVRGEGGGFVVLKTLA 249 Query 221 AALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAH 280 AL DGD IHA+IRG+A N G SA GL+VPS A Q V+R+A A VD Q YVE H Sbjct 250 RALADGDDIHAVIRGTATNNGG-SARGLSVPSAAAQEAVLRQAYERADVDPAQAQYVELH 308 Query 281 GTGTKIGDPIEARALGEIFAARQR---RPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIEN 337 GTGTK+GDPIEA ALG + R R +P+ VGSVKTNIGH GAAGIAGLLK VL I + Sbjct 309 GTGTKVGDPIEAEALGAVLG-RGRSSAQPLVVGSVKTNIGHLEGAAGIAGLLKTVLMIRH 367 Query 338 AVIPPSLNYV--GAAIDLDSLGLRVDTALTPWP--VADEPRRAGVSSFGMGGTNAHVILE 393 I SLN+ AI + LRV TA PWP A+EP AGVSSFG+GG+N HV+L Sbjct 368 RSIVASLNFAEPNPAIRFEEWRLRVATAAAPWPGSEAEEPLLAGVSSFGIGGSNCHVVLS 427 Query 394 QGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGW 453 P S A S A V VPWVL+ RS +A+ QA RL A + +D L DV W Sbjct 428 SAPVPPAGSAASEPGASSGAGV-VPWVLSGRSAEAVAAQAERLRARVESDPALRPADVAW 486 Query 454 SLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQ 513 SL+ R FDHRAVVVG+DR +L+AG+ ++ GA VG +F GQG+Q Sbjct 487 SLLHAREAFDHRAVVVGSDREQLLAGVRHVSPVAAGADPRVG---------VLFTGQGAQ 537 Query 514 WLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQ 573 +GM R LY R VFA A DE++A LD L S+ VMWG D GL++ T +AQPALF V+ Sbjct 538 RVGMARGLYERSPVFAAALDEILAELDPLLERSLAGVMWGDDPGLVDRTGWAQPALFAVE 597 Query 574 VALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMV 633 AL A+L+ +GV P ++GHS+GE+ AAYVAG SL DA RVVAAR RLMQALPAGG M Sbjct 598 AALFAVLRSYGVRPAFLLGHSIGEVTAAYVAGVWSLPDACRVVAARARLMQALPAGGAMA 657 Query 634 AVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAF 693 V E +V PLL EGV +AAVN SVV+SG + AV + L + +V RL VSHAF Sbjct 658 TVQLPEADVVPLLPEGVAVAAVNTAGSVVVSGPRDAVEGL---LASVSVKVTRLRVSHAF 714 Query 694 HSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDG 753 HS LMDPM+ EF++VL V R PRI +VSN+TG + G SP YWV VR VRF DG Sbjct 715 HSALMDPMLAEFARVLESVEFREPRIPVVSNLTG-VVGDELTSPGYWVRQVRGTVRFADG 773 Query 754 VGLAESLGARVFVEVGPGAGL----EASVALLARDRPEVESVLAGVGRLFAEGVAVDWSS 809 V G V VE GP L + S +L R R + E+VLA VG L+A GV VDW+ Sbjct 774 VRWLGEQGVSVLVEAGPDGVLSGLVDNSAPMLRRKRDDGEAVLAAVGHLWANGVTVDWAP 833 Query 810 VFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVEL 869 VF GL RRV LPTY F RQR+W G V T K AG RLQ E R L ++ Sbjct 834 VFEGLDARRVALPTYAFQRQRYWPGVE---RVSPTPKLAG---RLQL----ESGRSLRDV 883 Query 870 VCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYP 929 V AA+VLG +D F++LGFDS++GVELRN LQ G+ L + +FDYP Sbjct 884 VRESAAVVLGHHPDTALDTHRTFRELGFDSLTGVELRNLLQSRT---GIELAGSAVFDYP 940 Query 930 TASALAECL 938 T + LAE L Sbjct 941 TVTRLAEHL 949 Score = 650 bits (1677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/878 (46%), Positives = 532/878 (61%), Gaps = 65/878 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 + ++G+ACR+P V P +LWDL+ G + Sbjct 2643 VVLVGMACRYPGGVTGPDELWDLVAAGVDGITPFPADRGWDLDGLLGSGETGSGSSATGE 2702 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G ++ V FDA FF++SPREA A DP+QRL LE++WE LE A + P +L G P V+ G Sbjct 2703 GGFLEGVDGFDAAFFSISPREARATDPQQRLLLEVSWEALEQAGIDPHSLAGSPTGVFAG 2762 Query 95 AMNDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 + YA ++ +++ H G + ++I+ RV++A GL GP+V++D+ SSSLVA+HL Sbjct 2763 VYSSGYADLVARGGEQLQGHQITGGAASVISGRVAYALGLEGPAVSVDTACSSSLVAMHL 2822 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R GE LA+AGGV + + + G +SP G +F + A+G +G G+ Sbjct 2823 AAQALRAGECSLALAGGVTVMATADAFVGFTAQGGLSPDGRCRSFADSAEGTGWSEGVGV 2882 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 V+L+ + A +G + A+ R SAV G S GLT P+ Q +IR+A++ AG+ Sbjct 2883 VVLERLSDARRNGHEVLAVFRSSAVNQDGAS-NGLTAPNGPSQRRLIRQALAAAGLSSAD 2941 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+ G++K Sbjct 2942 VDAVEAHGTGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHTQAAAGVGGVIKM 3001 Query 332 VLAIENAVIPPSLNYVG--AAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+ + ++P +L+ + +D +R+ T PWP PRRAGVSSFG+ GTNAH Sbjct 3002 VMALRHGILPRTLHVDAPTSQVDWTEGNVRLLTDAVPWPETGRPRRAGVSSFGVSGTNAH 3061 Query 390 VILEQGPTQSPEIV-----------ESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLA 438 VILE S + V + G A VAVPWVL+AR+ +A+ QA RL+ Sbjct 3062 VILEAPSVSSTSPAPAGVAADGSGADEVVSGGREARVAVPWVLSARTAEAVRAQAARLVE 3121 Query 439 HLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRAR 498 H+ AD L LDVGWSLV TR+VFDHRAVVVG+DR +L+AG+ ++ GA VG Sbjct 3122 HVEADPSLQPLDVGWSLVDTRAVFDHRAVVVGSDREQLLAGVRHVSPVAAGADPRVG--- 3178 Query 499 SVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGL 558 +F GQG+Q +GM R LY R VFA A DE++A LD L S+ VMWG D GL Sbjct 3179 ------VLFTGQGAQRVGMARGLYERSPVFAAALDEILAELDPLLERSLAGVMWGDDPGL 3232 Query 559 LESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAA 618 ++ T +AQPALF V+ AL A+L+ +GV P ++GHS+GE+ AAYVAG SL DA RVVAA Sbjct 3233 VDRTGWAQPALFAVEAALFAVLRSYGVRPAFLLGHSIGEVTAAYVAGVWSLPDACRVVAA 3292 Query 619 RGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLV 678 R RLMQALPAGG M V E +V PLL EGV +AAVN SVV+SG + AV + L Sbjct 3293 RARLMQALPAGGAMATVQLPEADVVPLLPEGVAVAAVNTAGSVVVSGPRDAVEGL---LA 3349 Query 679 GLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPA 738 + +V RL VSHAFHS LMDPM+ EF++VL V R PRI +VSN+TG + G SP Sbjct 3350 SVSVKVTRLRVSHAFHSALMDPMLAEFARVLESVEFREPRIPVVSNLTG-VVGDELTSPG 3408 Query 739 YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGL----EASVALLARDRPEVESVLAG 794 YWV VR VRF DGV G V VE GP L + S +L R R + E+VLA Sbjct 3409 YWVRQVRGTVRFADGVRWLGEQGVSVLVEAGPDGVLSGLVDNSAPMLRRKRDDGEAVLAA 3468 Query 795 VGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 +G L+A GV VDW+ VF GL RRV LPTY F QRFW Sbjct 3469 LGHLYARGVEVDWAPVFEGLDARRVALPTYAFQHQRFW 3506 Score = 639 bits (1649), Expect = 0.0, Method: Compositional matrix adjust. Identities = 393/869 (46%), Positives = 528/869 (61%), Gaps = 65/869 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLR-----------------------DGREAA-----G 36 + ++G+ACR+P V P +LWDL+ DG A+ G Sbjct 5776 VVLVGMACRYPGGVTGPDELWDLVAAGADGITPFPADRGWDLDALLGVDGSAASATAEGG 5835 Query 37 SIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAM 96 + +FDA FF +SPREA A DP+QRL LE++WE LE A + P +L G V+ G Sbjct 5836 FLAGADEFDAAFFRISPREAQATDPQQRLLLEVSWEALEQAGIDPLSLAGSSTGVFAGVY 5895 Query 97 NDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLAC 155 + YA ++ +++ H G + ++I+ RV++ GL GP+V++D+ SSSLVA+HLA Sbjct 5896 SSGYADLVARGGEQLQGHQITGGAASVISGRVAYTLGLEGPAVSVDTACSSSLVAMHLAA 5955 Query 156 ESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVL 215 +++R GE LA+AGGV + + + G +SP G +F + ADG +G G+V+ Sbjct 5956 QALRAGECTLALAGGVTVMATPDAFVWFTVQGGLSPDGRCRSFADSADGTGWSEGVGVVV 6015 Query 216 LKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVH 275 ++ + A+ +G + A++R SAV G S GLT P+ Q VIR+A++ AG+ V Sbjct 6016 MERLSDAVRNGHEVLAVMRSSAVNQDGAS-NGLTAPNGPSQQRVIRQALAAAGLSSADVD 6074 Query 276 YVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGH AAG+ G++K V+ Sbjct 6075 AVEAHGTGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHAQAAAGVGGVIKMVM 6134 Query 334 AIENAVIPPSLNYVGAAIDLDSL--GLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVI 391 A+ + V+P +L+ + +D +R+ T PWP PRRAGVSSFG+ GTNAHVI Sbjct 6135 ALRHGVLPRTLHVDAPSTQVDWTQGDVRLLTDAVPWPETGRPRRAGVSSFGVSGTNAHVI 6194 Query 392 LE----QGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLT 447 LE GP PE G PV PWVL+AR+ A+ QA RLL + +D L Sbjct 6195 LEAPEATGPEPEPE-------PGVGGPV--PWVLSARTADAVRAQAARLLERVGSDPSLR 6245 Query 448 ALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVF 507 LDVGWSLV TR+VFDHRAVVVG+DR +L+AGL ++ A++ + +F Sbjct 6246 PLDVGWSLVDTRAVFDHRAVVVGSDREQLLAGLRNVSPAV---------AQTAPRLGVLF 6296 Query 508 PGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQP 567 GQG+Q +GM R LY R VFA A DE++A LD L S+ VMWG D GL++ T +AQP Sbjct 6297 TGQGAQRVGMARGLYERSPVFAAALDEILAELDPLLERSLAGVMWGDDPGLVDRTGWAQP 6356 Query 568 ALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALP 627 ALF V+ AL A+L+ +GV P ++GHS+GE+ AAYVAG SL DA RVVAAR RLMQALP Sbjct 6357 ALFAVEAALFAVLRSYGVRPAFLLGHSIGEVTAAYVAGVWSLPDACRVVAARARLMQALP 6416 Query 628 AGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRL 687 AGG M V E +V PLL EGV +AAVN SVV+SG + AV + L + +V RL Sbjct 6417 AGGAMATVQLPEADVVPLLPEGVAVAAVNTAGSVVVSGPRDAVEGL---LASVSVKVTRL 6473 Query 688 AVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKP 747 VSHAFHS LMDPM+ EF++VL V R PRI +VSN+TG + G SP YWV VR Sbjct 6474 RVSHAFHSALMDPMLAEFARVLESVEFREPRIPVVSNLTG-VVGDELTSPGYWVRQVRGT 6532 Query 748 VRFFDGVGLAESLGARVFVEVGPGAGL----EASVALLARDRPEVESVLAGVGRLFAEGV 803 VRF DGV G V VE GP L + S +L R R + E+VLA VG L+A GV Sbjct 6533 VRFADGVRWLGEQGVSVLVEAGPDGVLSGLVDNSAPMLRRKRDDGEAVLAAVGHLWANGV 6592 Query 804 AVDWSSVFAGLGGRRVELPTYGFARQRFW 832 VDW+ VF GL +RV+LPTY F QRFW Sbjct 6593 TVDWAPVFEGLHAQRVKLPTYAFQHQRFW 6621 Score = 517 bits (1331), Expect = 5e-144, Method: Compositional matrix adjust. Identities = 358/886 (41%), Positives = 496/886 (56%), Gaps = 76/886 (8%) Query 6 IAIIGLACRFPTVVS-PGDLWDLLRDGREAAGS-----------------------IDNV 41 I ++G+ACRFP VS P LW L+ + +A G + V Sbjct 969 IVLVGMACRFPGGVSDPDGLWRLVAEEADATGPFPTDRGWDLDRLQEVSATSRGGFVAGV 1028 Query 42 ADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYA 101 FDA FF +SPREA A DP+QRL LE++WE LE A + P TL G P V+ GA Y Sbjct 1029 DGFDAAFFRISPREALATDPQQRLLLEVSWEALEQAGIDPGTLAGTPTGVFAGAYGSGYG 1088 Query 102 VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTG 161 L ++ +++ H G + ++I+ RV++A GL GP+V++D+ SSSLVA+HLA +++RTG Sbjct 1089 DL-VSREQLQGHLLTGGAGSVISGRVAYALGLEGPAVSVDTACSSSLVAMHLAAQALRTG 1147 Query 162 EAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQA 221 E LA+AGGV + E + ++ G +F + ADG +G G+V+++ + Sbjct 1148 ECNLALAGGVTVMATPEMFLEFTAQNGLAEDGRCRSFADSADGTGWSEGVGVVVMERLSD 1207 Query 222 ALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHG 281 A+ +G + A++R SAV G S GLT P+ Q VIR+A++ AG+ V VEAHG Sbjct 1208 AVRNGHEVLAVMRSSAVNQDGAS-NGLTAPNGPSQQRVIRQALAAAGLSSADVDAVEAHG 1266 Query 282 TGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAV 339 TGT++GDPIEA+AL + + RP+ +GS+K+NIGH AAG+ G++K V+A+ + V Sbjct 1267 TGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHAQAAAGVGGVIKMVMALRHGV 1326 Query 340 IPPSLNY--VGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPT 397 +P +L+ +D +R+ T PWP PRRAGVSSFG+ GTNAHVILE Sbjct 1327 LPRTLHVDEPSTQVDWTQGDVRLLTDAVPWPETGRPRRAGVSSFGVSGTNAHVILEAPEA 1386 Query 398 QSPEIV----------ESVAAAGSNA-PVA-----VPWVLAARSPQALTNQAGRLLAHLT 441 P ESVAA A P A VPW+++ S +A+ QA RLL H+ Sbjct 1387 TEPAATGPAVAESNAGESVAAESVVAEPEAGGGGVVPWIISGASEEAVRAQAARLLEHVE 1446 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVG 501 + L +DV WSL+S R+ HR VGADR L+AGL +AAGE VV R Sbjct 1447 SVPELRPVDVAWSLISARAALTHRTAAVGADRDELLAGLRAVAAGE----VVPRTVRPGD 1502 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLES 561 K VFVFPGQG+QW+GM ++L G VFA + E L+ + S+ V+ D L Sbjct 1503 KVVFVFPGQGAQWVGMAQELIGSSPVFASSMGECAEALEPFVDWSLADVL--GDESALRR 1560 Query 562 TEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGR 621 + QPAL+ V V+LAA+ + +GV P V+GHS GEIAAA VAGALSL D ARVVA R R Sbjct 1561 VDVVQPALWAVMVSLAAVWRSYGVEPAAVVGHSQGEIAAACVAGALSLSDGARVVALRSR 1620 Query 622 -LMQALPAGGVM---VAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRL 677 + + L GG+M V AA+ D +A G+ +A VN P + V+SGE AA +DRL Sbjct 1621 AIAERLTGGGMMALSVPAAAARDLIAD--RPGLSLAVVNGPGATVVSGEAAA----LDRL 1674 Query 678 VGL----GRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAG 733 G + RR+AV +A HSVL++ + + LA + + ++ +VS+VTG+L Sbjct 1675 QAYCDEHGIQARRIAVDYASHSVLVEQIRDRLLTDLAAITPQTSKVPVVSSVTGELMDTV 1734 Query 734 YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRP 786 YW ++R V F + A A V VEV P L V L R Sbjct 1735 GWDAEYWFRNLRNTVLFEQALTAAS---ADVVVEVSPHPVLLPVIQDTVPVVGTLRRGEG 1791 Query 787 EVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 ++ ++ V + A G+AVDWS VFAG G RV LPTY F QRFW Sbjct 1792 GLQRLVTSVAQAHAYGIAVDWSPVFAGRGAERVALPTYAFQHQRFW 1837 Score = 516 bits (1329), Expect = 7e-144, Method: Compositional matrix adjust. Identities = 350/877 (40%), Positives = 498/877 (57%), Gaps = 69/877 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 I ++G+ACRFP V P LW L+ +G ++ Sbjct 4143 IVLVGMACRFPGGVQDPEGLWRLVAEGTDSITGFPADRGWNFDELLGTAGPGSGTIATGQ 4202 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G +D VA FDA FF +SPREA A DP+QRL LE++WE LE + + P TL G P V++G Sbjct 4203 GGFLDEVAGFDAGFFRISPREALATDPQQRLLLEVSWEALEQSGIAPSTLVGSPTGVFVG 4262 Query 95 AMNDDYAVLTLAADRVDH----HAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVA 150 A + YA AA +H H G + ++I+ RV++A GL GP+V++D+ SSSLVA Sbjct 4263 AYQNGYA--EFAARSGEHELQGHLITGGAGSVISGRVAYALGLEGPAVSVDTACSSSLVA 4320 Query 151 VHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDG 210 +HLA +++R+GE LA+AGGV + + + G ++ G +F + ADG +G Sbjct 4321 MHLAAQALRSGECSLALAGGVMVMSTPDAFVGFTAQGGLAGDGRCKSFSDTADGTGWSEG 4380 Query 211 GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVD 270 G+V+++ + A +G + A++R SAV G S GLT P+ Q +IR+A++ AG+ Sbjct 4381 VGVVVMERLSDAERNGHEVLAVMRSSAVNQDGAS-NGLTAPNGPSQQRLIRQALAAAGLS 4439 Query 271 CHQVHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGL 328 V VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGH AAG+AG+ Sbjct 4440 SADVDAVEAHGTGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHAQAAAGVAGV 4499 Query 329 LKAVLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGT 386 +K V+A+ + ++P +L+ A +D +R+ T PWP D PRRAGVS+FG+ GT Sbjct 4500 IKMVMALRHGILPKTLHVDAPASQVDWTEGNVRLLTEAVPWPETDRPRRAGVSAFGVSGT 4559 Query 387 NAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGL 446 NAHVILE +P +++ + +PW L+ ++ A+ QA RLL HL + L Sbjct 4560 NAHVILE-----APARIDAEPPSEPATDGPLPWALSGKTGAAVQAQAARLLEHLESVPSL 4614 Query 447 TALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFV 506 DV WSL+++R FD RAVVVGAD L AGL +A G P GVV G R+ G+ VFV Sbjct 4615 HPADVAWSLIASRESFDQRAVVVGADHDELRAGLRAIAVGSPAPGVVRG-TRTGGRVVFV 4673 Query 507 FPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQ 566 FPGQG+QW+GM ++L G VFA + E L+ + S+ V+ D L + Q Sbjct 4674 FPGQGAQWVGMAQELIGSSPVFASSMGECAEALEPFVDWSLADVL--GDESALRRVDVVQ 4731 Query 567 PALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGR-LMQA 625 PAL+ V V+LAA+ + +GV P V+GHS GEIAAA VAGALSL D ARVVA R R + + Sbjct 4732 PALWAVMVSLAAVWRSYGVEPAAVVGHSQGEIAAACVAGALSLSDGARVVALRSRAIAER 4791 Query 626 LPAGGVM---VAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGR 682 L GG+M V AA+ D +A GV +AA+N P SVV+SGE A+ + G Sbjct 4792 LTGGGMMALSVPAAAARDLIAD--RPGVSLAAINGPSSVVVSGEADALDSLQAHCEEQGV 4849 Query 683 RVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVE 742 R RR+AV +A HSVL++ + + LA + + ++ +VS+VTG+ YW Sbjct 4850 RARRIAVDYASHSVLVEQIRDRLLTDLAAITPQTSKVPVVSSVTGESMDTVGWDAEYWFR 4909 Query 743 HVRKPVRFFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRPEVESVLAGV 795 ++R V F + A G V +EV P L +V L R ++ +L V Sbjct 4910 NLRNTVLFEQALTAA---GPGVIIEVSPHPVLLPAVQDIAPAVGTLRRGEGDLRRLLESV 4966 Query 796 GRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 + A GV+VDW + GRRV LPTY F QRFW Sbjct 4967 AQAHAYGVSVDWKRLVT---GRRVPLPTYAFQHQRFW 5000 Score = 516 bits (1328), Expect = 1e-143, Method: Compositional matrix adjust. Identities = 341/886 (39%), Positives = 497/886 (57%), Gaps = 86/886 (9%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGREAAGS--------------------------- 37 I ++G+ACRFP V P DLW L+ +G + GS Sbjct 7465 IVLVGMACRFPGDVQGPEDLWRLISEGTDGIGSFPTDRGWDLDALLGPDGSGTGTSITAE 7524 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + +FDA FF++SPREA A DP+QRL LE+ WE LE + P L G V++G Sbjct 7525 GGFLTGIDEFDAAFFHISPREAQATDPQQRLLLEVAWEALERTGITPSALAGSATGVFVG 7584 Query 95 AMNDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 A Y ++ D + H G + ++++ RV++A GL GP+V++D+ SSSLVA+HL Sbjct 7585 AYQTGYLDLVNRGHDDLRGHVLTGAATSVMSGRVAYALGLEGPAVSVDTACSSSLVAMHL 7644 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE LA+AGGV + + + + G +S G +FD+ ADG +G G+ Sbjct 7645 AAQALRSGECSLALAGGVTVMATSDMFVGLTKQGGLSADGRCRSFDDAADGTGWSEGVGV 7704 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 V+++ + A +G + A+ R SAV G S GLT P+ Q VIR+A++ AG+ Sbjct 7705 VVMERLSEARRNGHEVLAVFRASAVNQDGAS-NGLTAPNGPSQQRVIRQALATAGLSPAD 7763 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + + +P+ +GS+K+NIGHT AAG+ G++K Sbjct 7764 VDAVEAHGTGTRLGDPIEAQALLATYGGDRPGDKPLWLGSLKSNIGHTQAAAGVGGVIKM 7823 Query 332 VLAIENAVIPPSLNYV--GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+ + ++P +L+ +D +R+ T PWP PRRAGVS+FG+ GTNAH Sbjct 7824 VMALRHGILPKTLHVTEPSTKVDWTQGDVRLLTEAVPWPETGRPRRAGVSAFGISGTNAH 7883 Query 390 VILE--------QGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLT 441 +ILE GP P++ PV VPWV++ ++ A+ QA RLL H+ Sbjct 7884 IILEAPEPDPAGAGPETMPDVT----------PV-VPWVVSGKTAAAVRAQAARLLEHVE 7932 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVG 501 + GL +DVGWSL+++R F++RA VV DR L+AGL ++ V AR Sbjct 7933 SVPGLRPVDVGWSLLASRETFEYRAAVVSGDRDELLAGLRAIS----DDAVQPDPARFPD 7988 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLES 561 + VFVFPGQG+QW+GM ++L G VFA + E L+ + S+ V+ D L Sbjct 7989 RVVFVFPGQGAQWVGMAQELIGSSPVFASSMGECAEALEPFVDWSLADVL--GDESALRR 8046 Query 562 TEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGR 621 + QPAL+ V V+LAA+ + +GV P V+GHS GEIAAA VAGALSL D ARVVA R R Sbjct 8047 VDVVQPALWAVMVSLAAVWRSYGVEPAAVVGHSQGEIAAACVAGALSLSDGARVVALRSR 8106 Query 622 -LMQALPAGGVM---VAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRL 677 + + L GG+M V AA+ D +A G+ +A VN P + V+SGE AA +DRL Sbjct 8107 AIAERLTGGGMMALSVPAAAARDLIAD--RPGLSLAVVNGPGATVVSGEAAA----LDRL 8160 Query 678 VGL----GRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAG 733 G + RR+AV +A HSVL++ + + LA + + ++ +VS+VTG+L Sbjct 8161 QAYCDEHGIQARRIAVDYASHSVLVEQIRDRLLTDLAAITPQTSKVPVVSSVTGELMDTV 8220 Query 734 YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRP 786 YW ++R V F + AE V +E+ P L V L R Sbjct 8221 GWDAEYWFRNLRNTVLFEQALTAAEP---GVVIEISPHPVLLPVIQDTVPVVGTLRRGEG 8277 Query 787 EVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 ++ ++ V + A G+AVDW+++FAG G RRV LPTY F R RFW Sbjct 8278 GLQRLVTSVAQAHAYGIAVDWTTLFAGHGARRVPLPTYAFQRGRFW 8323 Score = 74.3 bits (181), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 42/90 (47%), Positives = 56/90 (63%), Gaps = 3/90 (3%) Query 854 LQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAI 913 L +L P E ++ LVELV AA+VLG S+ I+ + F +LGFDS++ VELRN LQ Sbjct 7358 LAALPPAEREKALVELVSESAAVVLGHSSAAQINAQQPFSELGFDSLTSVELRNLLQSRT 7417 Query 914 GLPGLSLPRTLIFDYPTASALAECLGQLLG 943 GLSL + +FDYPT + LA L +G Sbjct 7418 ---GLSLAASAVFDYPTVTRLAAHLAGEIG 7444 Score = 70.1 bits (170), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/91 (43%), Positives = 56/91 (62%), Gaps = 3/91 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 R L+ E Q+ L++LV AA VLG S+ + + F DLGFDS++ V+LRN L+ Sbjct 5664 RFAGLSAAERQQALIDLVRESAAAVLGYGSAAQLADDQPFSDLGFDSLTAVDLRNTLRTR 5723 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLG 943 GL++P TL+FDYPT + +A L + LG Sbjct 5724 T---GLNMPATLVFDYPTVARVAGYLAEELG 5751 Score = 65.1 bits (157), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 38/100 (38%), Positives = 57/100 (57%), Gaps = 3/100 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+ + ++ L +LV AA VLG S+ ID + +F +LGFDS++ VELRN L+ Sbjct 9394 RLAGLSRADREKILTDLVRGSAATVLGHSSAGRIDTDRSFSELGFDSLTSVELRNLLRTR 9453 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDE 952 G +L ++FDYPT + LA + L S D++ Sbjct 9454 T---GRTLSSGVVFDYPTVTQLAGYVDSLFAPAEPSGDED 9490 Score = 65.1 bits (157), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 39/86 (46%), Positives = 52/86 (61%), Gaps = 3/86 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+ + + LVELV AA VLG S I+ F++LGFDS++ VELRN LQ Sbjct 2539 RLAGLSGDQARALLVELVGDAAATVLGHASGTRINTGQPFKELGFDSLTAVELRNLLQSR 2598 Query 913 IGLPGLSLPRTLIFDYPTASALAECL 938 G +LP +++FDYPT + LA L Sbjct 2599 T---GRALPSSVVFDYPTVTRLAAFL 2621 Score = 63.9 bits (154), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/90 (44%), Positives = 51/90 (57%), Gaps = 3/90 (3%) Query 854 LQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAI 913 L +L E ++ LV+LV AA VLG SS +D + F++ GFDS++ VELRN L Sbjct 4036 LAALPSAEREQALVDLVRAAAASVLGHSSSAQVDVDQPFKEQGFDSLTAVELRNALLAGT 4095 Query 914 GLPGLSLPRTLIFDYPTASALAECLGQLLG 943 G SLP + FDYPT + LA L G Sbjct 4096 ---GTSLPASAAFDYPTVTRLAAHLSAQFG 4122 >gi|115338567|gb|ABI94379.1| tautomycetin biosynthetic PKS [Streptomyces sp. CK4412] Length=9648 Score = 801 bits (2069), Expect = 0.0, Method: Compositional matrix adjust. Identities = 492/969 (51%), Positives = 602/969 (63%), Gaps = 65/969 (6%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDG-------------------REAA----GSIDNVA 42 +A++GL+CR P + W+LLR G R AA G + V Sbjct 126 VAVVGLSCRLPHAENLDAFWELLRSGASGVTEVGDDRWPGQGDPARPAAVRHGGFLPQVD 185 Query 43 DFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAV 102 FD FF +SPREA MDP+QRLALEL+WE LE A +VP LRG+P+ VY+G M DDYA Sbjct 186 TFDPGFFGISPREAVEMDPQQRLALELSWEALEHAGIVPGALRGEPVPVYVGVMADDYAK 245 Query 103 LTLA--ADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRT 160 L LA D D +A AGT RA+IANR+S G++G S+ +D+GQSSSLVAVHLACE++ + Sbjct 246 LRLADAGDDPDPYAQAGTQRALIANRISHFLGVQGESMAVDTGQSSSLVAVHLACEALLS 305 Query 161 GEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQ 220 G A A+AGGV LNL ETA++ + G +S G Y FD RADGYV G+GGG V+LK + Sbjct 306 GRATAALAGGVQLNLLEETALMAAKLGTLSADGQCYTFDARADGYVRGEGGGFVVLKTLA 365 Query 221 AALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAH 280 AL DGD IHA+IRG+A N G SA GL+VPS A Q V+R+A A VD Q YVE H Sbjct 366 RALADGDHIHAVIRGTATNNGG-SARGLSVPSAAAQEAVLRQAYERADVDPAQAQYVELH 424 Query 281 GTGTKIGDPIEARALGEIFAARQR---RPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIEN 337 GTGTK+GDPIEA ALG + R R +P+ VGSVKTNIGH GAAGIAGLLK VL I + Sbjct 425 GTGTKVGDPIEAEALGAVLG-RGRSSAQPLVVGSVKTNIGHLEGAAGIAGLLKTVLMIRH 483 Query 338 AVIPPSLNYV--GAAIDLDSLGLRVDTALTPWP--VADEPRRAGVSSFGMGGTNAHVILE 393 I SLN+ AI + LRV TA PWP A+EP AGVSSFG+GG+N HV+L Sbjct 484 RSIVASLNFAEPNPAIRFEEWRLRVATAAAPWPGSEAEEPLLAGVSSFGIGGSNCHVVLS 543 Query 394 QGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGW 453 P S A S A V VPWVL+ RS +A+ QA RL A + +D L DV W Sbjct 544 SAPVPPAGSAASEPGASSGAGV-VPWVLSGRSAEAVAAQAERLRARVESDPALRPADVAW 602 Query 454 SLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQ 513 SL+ R FDHRAVVVG+DR +L+AG+ ++ GA VG +F GQG+Q Sbjct 603 SLLHAREAFDHRAVVVGSDREQLLAGVRHVSPVAAGADPRVG---------VLFTGQGAQ 653 Query 514 WLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQ 573 +GM R LY R VFA A DE++A LD L S+ VMWG D GL++ T +AQPALF V+ Sbjct 654 RVGMARGLYERSPVFAAALDEILAELDPLLERSLAGVMWGDDPGLVDRTGWAQPALFAVE 713 Query 574 VALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMV 633 AL A+L+ +GV P ++GHS+GE+ AAYVAG SL DA RVVAAR RLMQALPAGG M Sbjct 714 AALFAVLRSYGVRPAFLLGHSIGEVTAAYVAGVWSLPDACRVVAARARLMQALPAGGAMA 773 Query 634 AVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAF 693 V E +V PLL EGV +AAVN SVV+SG + AV + L + +V RL VSHAF Sbjct 774 TVQLPEADVIPLLPEGVAVAAVNTAGSVVVSGPRDAVEGL---LASVSVKVTRLRVSHAF 830 Query 694 HSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDG 753 HS LMDPM+ EF++VL V R PRI +VSN+TG + G SP YWV VR VRF DG Sbjct 831 HSALMDPMLAEFARVLESVEFREPRIPVVSNLTG-VVGDELTSPGYWVRQVRGTVRFADG 889 Query 754 VGLAESLGARVFVEVGPGAGLEASV----ALLARDRPEVESVLAGVGRLFAEGVAVDWSS 809 V G V VE GP L V +L R R + E+VLA VG L+A GV VDW+ Sbjct 890 VRWLGEQGVSVLVEAGPDGVLSGLVDNGAPMLRRKRDDSEAVLAAVGHLWANGVTVDWAP 949 Query 810 VFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVEL 869 VF GL +RV LPTY F RQR+W G V T K AG RLQ E R L ++ Sbjct 950 VFEGLDAQRVALPTYAFQRQRYWPGVE---RVSPTPKLAG---RLQL----ESGRSLRDV 999 Query 870 VCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYP 929 V AA+VLG +D F++LGFDS++GVELRN LQ G+ L + +FDYP Sbjct 1000 VRESAAVVLGHHPDTALDTHRTFRELGFDSLTGVELRNLLQSRT---GIELAGSAVFDYP 1056 Query 930 TASALAECL 938 T + LAE L Sbjct 1057 TVTRLAEHL 1065 Score = 649 bits (1674), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/879 (45%), Positives = 534/879 (61%), Gaps = 67/879 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 + ++G+ACR+P V P +LWDL+ G + Sbjct 2759 VVLVGMACRYPGGVTGPDELWDLVAAGVDGITPFPADRGWDLDGLLGSGETGSGSSATGE 2818 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G ++ V FDA FF++SPREA A DP+QRL LE++WE LE A + P +L G P V+ G Sbjct 2819 GGFLEGVDGFDAAFFSISPREARATDPQQRLLLEVSWEALEQAGIDPHSLAGSPTGVFAG 2878 Query 95 AMNDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 + YA ++ +++ H G + ++I+ RV++A GL GP+V++D+ SSSLVA+HL Sbjct 2879 VYSSGYADLVARGGEQLQGHQITGGAASVISGRVAYALGLEGPAVSVDTACSSSLVAMHL 2938 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R GE LA+AGGV + + + G +SP G +F + A+G +G G+ Sbjct 2939 AAQALRAGECSLALAGGVTVMATADAFVGFTAQGGLSPDGRCRSFADSAEGTGWSEGVGV 2998 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 V+L+ + A +G + A+ R SAV G S GLT P+ Q +IR+A++ AG+ Sbjct 2999 VVLERLSDARRNGHEVLAVFRSSAVNQDGAS-NGLTAPNGPSQQRLIRQALAAAGLSSAD 3057 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+ G++K Sbjct 3058 VDAVEAHGTGTRLGDPIEAQALLSTYGQDRPGDRPLWLGSLKSNIGHTQAAAGVGGVIKM 3117 Query 332 VLAIENAVIPPSLNYVG--AAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+ + ++P +L+ + +D +R+ T PWP PRRAGVSSFG+ GTNAH Sbjct 3118 VMALRHGILPRTLHVDAPTSQVDWTEGNVRLLTGAVPWPETGRPRRAGVSSFGVSGTNAH 3177 Query 390 VILEQGPTQSPEIVES-----------VAAAGSNAPVAVPWVLAARSPQALTNQAGRLLA 438 VILE S + V + G A VAVPWVL+AR+ +A+ QA RL+ Sbjct 3178 VILEAPSVSSTSPAPAGVAADGSGAGEVVSGGREARVAVPWVLSARTAEAVRAQAARLVE 3237 Query 439 HLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRAR 498 H+ AD L +DVGWSLV TR+VFDHRAVVVG+DR +L+AG+ ++ GA VG Sbjct 3238 HVEADPSLRPVDVGWSLVDTRAVFDHRAVVVGSDREQLLAGVRHVSPVAAGADPRVG--- 3294 Query 499 SVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGL 558 +F GQG+Q +GM R LY R VFA A DE++A LD L S+ VMWG D GL Sbjct 3295 ------VLFTGQGAQRVGMARGLYERSPVFAAALDEILAELDPLLERSLAGVMWGDDPGL 3348 Query 559 LESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAA 618 ++ T +AQPALF V+ AL A+L+ +GV P ++GHS+GE+ AAYVAG SL DA RVVAA Sbjct 3349 VDRTGWAQPALFAVEAALFAVLRSYGVRPAFLLGHSIGEVTAAYVAGVWSLPDACRVVAA 3408 Query 619 RGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLV 678 R RLMQALPAGG M V E +V PLL EGV +AAVN SVV+SG + A V+RL+ Sbjct 3409 RARLMQALPAGGAMATVQLPEADVIPLLPEGVAVAAVNTAGSVVVSGPRDA----VERLL 3464 Query 679 G-LGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSP 737 + +V RL VSHAFHS LMDPM+ EF++VL V R PRI +VSN+TG + G SP Sbjct 3465 ASVSVKVTRLRVSHAFHSALMDPMLAEFARVLESVEFREPRIPVVSNLTG-VVGDELTSP 3523 Query 738 AYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGL----EASVALLARDRPEVESVLA 793 YWV VR VRF DGV G V VE GP L + S +L R R + E+VLA Sbjct 3524 GYWVRQVRGTVRFADGVRWLGEQGVSVLVEAGPDGVLSGLVDNSAPMLRRKRDDSEAVLA 3583 Query 794 GVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 +G L+A GV VDW+ VF G RRV+LPTY F QRFW Sbjct 3584 AIGHLWANGVTVDWAPVFEGRDARRVKLPTYAFQHQRFW 3622 Score = 635 bits (1639), Expect = 1e-179, Method: Compositional matrix adjust. Identities = 387/866 (45%), Positives = 522/866 (61%), Gaps = 55/866 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLR-----------------------DGREAA-----G 36 + ++G+ACR+P V P +LWDL+ DG A+ G Sbjct 5892 VVLVGMACRYPGGVTGPDELWDLVAAGADGITPFPADRGWDLDALLGVDGSAASATAEGG 5951 Query 37 SIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAM 96 + +FDA FF +SPREA A DP+QRL LE++WE LE A + P +L G V+ G Sbjct 5952 FLAGAGEFDAAFFRISPREAQATDPQQRLLLEVSWEALEQAGIDPLSLAGSSTGVFAGVY 6011 Query 97 NDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLAC 155 + YA ++ +++ H G + ++I+ RV++ GL GP+V++D+ SSSLVA+HLA Sbjct 6012 SSGYADLVARGGEQLQGHQITGGAASVISGRVAYTLGLEGPAVSVDTACSSSLVAMHLAA 6071 Query 156 ESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVL 215 +++R GE LA+AGGV + + + G +SP G +F + ADG +G G+V+ Sbjct 6072 QALRAGECSLALAGGVTVMATPDAFVWFTVQGGLSPDGRCRSFADSADGTGWSEGVGVVV 6131 Query 216 LKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVH 275 ++ + A+ +G + A++R SAV G S GLT P+ Q VIR+A++ AG+ V Sbjct 6132 MERLSDAVRNGHEVLAVMRSSAVNQDGAS-NGLTAPNGPSQQRVIRQALAAAGLSSADVD 6190 Query 276 YVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGH AAG+ G++K V+ Sbjct 6191 AVEAHGTGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHAQAAAGVGGVIKMVM 6250 Query 334 AIENAVIPPSLNY--VGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVI 391 A+ + V+P +L+ +D +R+ T PWP PRRAGVSSFG+ GTNAHVI Sbjct 6251 ALRHGVLPRTLHVDEPSTQVDWTQGDVRLLTDAVPWPETGRPRRAGVSSFGVSGTNAHVI 6310 Query 392 LEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDV 451 LE P + VPWVL+ ++ A+ QA RLL + +D L LDV Sbjct 6311 LE-APEATGPEPGPEPGPEPGVGGLVPWVLSGKTADAVRAQAARLLERVGSDPSLRPLDV 6369 Query 452 GWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQG 511 GWSLV TR+VFDHRAVVVG DR +L+AGL ++ A++ + +F GQG Sbjct 6370 GWSLVDTRAVFDHRAVVVGGDREQLLAGLRNVSPAV---------AQTAPRLGVLFTGQG 6420 Query 512 SQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFV 571 +Q +GM R LY R VFA A DE+VA LD L S+ VMWG D GL++ T +AQPALF Sbjct 6421 AQRVGMARGLYERSPVFAAALDEIVAELDPLLERSLFGVMWGDDPGLVDRTGWAQPALFA 6480 Query 572 VQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGV 631 V+ AL A+L+ +GV P ++GHS+GE+ AAYVAG SL DA RVVAAR RLMQALPAGG Sbjct 6481 VEAALFAVLRSYGVRPAFLLGHSIGEVTAAYVAGVWSLPDACRVVAARARLMQALPAGGA 6540 Query 632 MVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVG-LGRRVRRLAVS 690 M V E +V PLL EGV +AAVN SVV+SG + A V+RL+ + +V RL VS Sbjct 6541 MATVQLPEADVVPLLPEGVAVAAVNTAGSVVVSGPRDA----VERLLASVSVKVTRLRVS 6596 Query 691 HAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRF 750 HAFHS LMDPM+ EF++VL V R PRI +VSN+TG + G SP YWV VR VRF Sbjct 6597 HAFHSALMDPMLAEFARVLESVEFREPRIPVVSNLTG-VVGDELTSPGYWVRQVRGTVRF 6655 Query 751 FDGVGLAESLGARVFVEVGPGAGL----EASVALLARDRPEVESVLAGVGRLFAEGVAVD 806 DGV G V VE GP L + S +L R R + E+VLA +G L+A GV VD Sbjct 6656 ADGVRWLGEQGVSVLVEAGPDGVLSGLVDNSAPMLRRKRDDSEAVLAAIGHLWANGVTVD 6715 Query 807 WSSVFAGLGGRRVELPTYGFARQRFW 832 W+ F GL RRV+LPTY F QRFW Sbjct 6716 WAPAFEGLHARRVKLPTYAFQHQRFW 6741 Score = 517 bits (1332), Expect = 4e-144, Method: Compositional matrix adjust. Identities = 357/886 (41%), Positives = 498/886 (57%), Gaps = 76/886 (8%) Query 6 IAIIGLACRFPTVVS-PGDLWDLLRDGREAAGS-----------------------IDNV 41 I ++G+ACRFP VS P LW L+ + +A G + V Sbjct 1085 IVLVGMACRFPGGVSDPDGLWRLVAEEADATGPFPTDRGWDLDRLQEVSATSRGGFVAGV 1144 Query 42 ADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYA 101 FDA FF +SPREA A DP+QRL LE++WE LE A + P TL G P V+ GA Y Sbjct 1145 DGFDAAFFRISPREALATDPQQRLLLEVSWEALEQAGIDPGTLAGTPTGVFAGAYGSGYG 1204 Query 102 VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTG 161 L ++ +++ H G + ++I+ RV++A GL GP+V++D+ SSSLVA+HLA +++RTG Sbjct 1205 DL-VSREQLQGHLLTGGAGSVISGRVAYALGLEGPAVSVDTACSSSLVAMHLAAQALRTG 1263 Query 162 EAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQA 221 E LA+AGGV + E + ++ G +F + ADG +G G+V+++ + Sbjct 1264 ECNLALAGGVTVMATPEMFLEFTAQNGLAEDGRCRSFADSADGTGWSEGVGVVVMERLSD 1323 Query 222 ALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHG 281 A+ +G + A++R SAV G S GLT P+ Q VIR+A++ AG+ V VEAHG Sbjct 1324 AVRNGHEVLAVMRSSAVNQDGAS-NGLTAPNGPSQQRVIRQALAAAGLSSADVDAVEAHG 1382 Query 282 TGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAV 339 TGT++GDPIEA+AL + + RP+ +GS+K+NIGH AAG+ G++K V+A+ + V Sbjct 1383 TGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHAQAAAGVGGVIKMVMALRHGV 1442 Query 340 IPPSLNYVGAAIDLDSL--GLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILE---- 393 +P +L+ + +D +R+ T PWP PRRAGVSSFG+ GTNAHVILE Sbjct 1443 LPRTLHVDAPSTQVDWTQGDVRLLTDAVPWPETGRPRRAGVSSFGVSGTNAHVILEAPEA 1502 Query 394 -QGPTQSPEIVESVAAAGSNA------PVA-----VPWVLAARSPQALTNQAGRLLAHLT 441 + T P + ES A A P A VPW+++ S +A+ QA RLL H+ Sbjct 1503 TEPATTDPAVAESNAGESVAAESVVAEPEARGGGVVPWIISGASDEAVRAQAARLLEHVE 1562 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVG 501 + L +DV WSL+S R+ HR VGADR L+AGL +AAGE VV R Sbjct 1563 SVPELRPVDVAWSLISARAALTHRTAAVGADRDELLAGLRAVAAGE----VVPRMVRPGD 1618 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLES 561 K VFVFPGQG+QW+GM ++L G VFA + E L+ + S+ V+ D L Sbjct 1619 KVVFVFPGQGAQWVGMAQELLGSSPVFASSMGECAEALEPFVDWSLVDVL--GDESALRR 1676 Query 562 TEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGR 621 + QPAL+ V V+LAA+ + +GV P V+GHS GEIAAA VAGALSL D ARVVA R R Sbjct 1677 VDVVQPALWAVMVSLAAVWRSYGVEPAAVVGHSQGEIAAACVAGALSLSDGARVVALRSR 1736 Query 622 -LMQALPAGGVM---VAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRL 677 + + L GG+M V AA+ D +A G+ +A VN P + V+SGE AA +DRL Sbjct 1737 AIAERLTGGGMMALSVPAAAARDLIAD--RPGLSLAVVNGPGATVVSGEAAA----LDRL 1790 Query 678 VGL----GRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAG 733 G + RR+AV +A HSVL++ + + LA + + ++ +VS+VTG+L Sbjct 1791 QAYCDEHGIQARRIAVDYASHSVLVEQIRDRLLTDLAAITPQTSKVPVVSSVTGELMDTV 1850 Query 734 YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRP 786 YW ++R V F + A A V VEV P L V L R Sbjct 1851 GWDAEYWFRNLRNTVLFEQALTAAS---ADVVVEVSPHPVLLPVIQDTVPVVGTLRRGEG 1907 Query 787 EVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 ++ ++ V + A G+AVDWS VFAG G RV LPTY F QRFW Sbjct 1908 GLQRLVTSVAQAHAYGIAVDWSPVFAGRGAERVALPTYAFQHQRFW 1953 Score = 516 bits (1328), Expect = 1e-143, Method: Compositional matrix adjust. Identities = 341/886 (39%), Positives = 497/886 (57%), Gaps = 86/886 (9%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGREAAGS--------------------------- 37 I ++G+ACRFP V P DLW L+ +G + GS Sbjct 7585 IVLVGMACRFPGDVQGPEDLWRLISEGTDGIGSFPTDRGWDLDALLGPDGSGTGTSITAE 7644 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + +FDA FF++SPREA A DP+QRL LE+ WE LE + P L G V++G Sbjct 7645 GGFLTGIDEFDAAFFHISPREAQATDPQQRLLLEVAWEALERTGITPSALAGSATGVFVG 7704 Query 95 AMNDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 A Y ++ D + H G + ++++ RV++A GL GP+V++D+ SSSLVA+HL Sbjct 7705 AYQTGYLDLVNRGHDDLRGHVLTGAATSVMSGRVAYALGLEGPAVSVDTACSSSLVAMHL 7764 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE LA+AGGV + + + + G +S G +FD+ ADG +G G+ Sbjct 7765 AAQALRSGECSLALAGGVTVMATSDMFVGLTKQGGLSADGRCRSFDDAADGTGWSEGVGV 7824 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 V+++ + A +G + A+ R SAV G S GLT P+ Q VIR+A++ AG+ Sbjct 7825 VVMERLSEARRNGHEVLAVFRASAVNQDGAS-NGLTAPNGPSQQRVIRQALATAGLSPAD 7883 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + + +P+ +GS+K+NIGHT AAG+ G++K Sbjct 7884 VDAVEAHGTGTRLGDPIEAQALLATYGGDRPGDKPLWLGSLKSNIGHTQAAAGVGGVIKM 7943 Query 332 VLAIENAVIPPSLNYV--GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+ + ++P +L+ +D +R+ T PWP PRRAGVS+FG+ GTNAH Sbjct 7944 VMALRHGILPKTLHVTEPSTKVDWTQGDVRLLTEAVPWPETGRPRRAGVSAFGISGTNAH 8003 Query 390 VILE--------QGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLT 441 +ILE GP P++ PV VPWV++ ++ A+ QA RLL H+ Sbjct 8004 IILEAPEPDPAGAGPETMPDVT----------PV-VPWVVSGKTAAAVRAQAARLLEHVE 8052 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVG 501 + GL +DVGWSL+++R F++RA VV DR L+AGL ++ V AR Sbjct 8053 SVPGLRPVDVGWSLLASRETFEYRAAVVSGDRDELLAGLRAIS----DDAVQPAPARFPD 8108 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLES 561 + VFVFPGQG+QW+GM ++L G VFA + E L+ + S+ V+ D L Sbjct 8109 RVVFVFPGQGAQWVGMAQELLGSSPVFASSMGECAEALEPFVDWSLVDVL--GDESALRR 8166 Query 562 TEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGR 621 + QPAL+ V V+LAA+ + +GV P V+GHS GEIAAA VAGALSL D ARVVA R R Sbjct 8167 VDVVQPALWAVMVSLAAVWRSYGVEPAAVVGHSQGEIAAACVAGALSLSDGARVVALRSR 8226 Query 622 -LMQALPAGGVM---VAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRL 677 + + L GG+M V AA+ D +A G+ +A VN P + V+SGE AA +DRL Sbjct 8227 AIAERLTGGGMMALSVPAAAARDLIAD--RPGLSLAVVNGPGATVVSGEAAA----LDRL 8280 Query 678 VGL----GRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAG 733 G + RR+AV +A HSVL++ + + LA + + ++ +VS+VTG+L Sbjct 8281 QAYCDEHGIQARRIAVDYASHSVLVEQIRDRLLTDLAAITPQTSKVPVVSSVTGELMDTV 8340 Query 734 YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRP 786 YW ++R V F + AE V +E+ P L V L R Sbjct 8341 GWDAEYWFRNLRNTVLFEQALTAAEP---GVVIEISPHPVLLPVIQDTVPVVGTLRRGEG 8397 Query 787 EVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 ++ ++ V + A GV+VDW+++FAG G RRV LPTY F R RFW Sbjct 8398 GLQRLVTSVAQAHAHGVSVDWTTLFAGHGARRVPLPTYAFQRGRFW 8443 Score = 514 bits (1325), Expect = 2e-143, Method: Compositional matrix adjust. Identities = 350/877 (40%), Positives = 497/877 (57%), Gaps = 69/877 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 I ++G+ACRFP V P LW L+ +G ++ Sbjct 4259 IVLVGMACRFPGGVQDPEGLWRLVAEGTDSITGFPADRGWNFDELLGTAGPGSGTIATGQ 4318 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G +D VA FDA FF +SPREA A DP+QRL LE++WE LE + + P TL G P V++G Sbjct 4319 GGFLDEVAGFDAGFFRISPREALATDPQQRLLLEVSWEALEQSGIAPSTLVGSPTGVFVG 4378 Query 95 AMNDDYAVLTLAADRVDH----HAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVA 150 A + YA AA +H H G + ++I+ RV++A GL GP+V++D+ SSSLVA Sbjct 4379 AYQNGYA--EFAARSGEHELQGHLITGGAGSVISGRVAYALGLEGPAVSVDTACSSSLVA 4436 Query 151 VHLACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDG 210 +HLA +++R+GE LA+AGGV + + + G ++ G +F + ADG +G Sbjct 4437 MHLAAQALRSGECSLALAGGVMVMSTPDAFVGFTAQGGLAGDGRCKSFSDTADGTGWSEG 4496 Query 211 GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVD 270 G+V+++ + A +G + A++R SAV G S GLT P+ Q +IR+A++ AG+ Sbjct 4497 VGVVVMERLSDAERNGHEVLAVMRSSAVNQDGAS-NGLTAPNGPSQQRLIRQALAAAGLS 4555 Query 271 CHQVHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGL 328 V VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGH AAG+AG+ Sbjct 4556 SADVDAVEAHGTGTRLGDPIEAQALLATYGQDRPGDRPLWLGSLKSNIGHAQAAAGVAGV 4615 Query 329 LKAVLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGT 386 +K V+A+ + ++P +L+ A +D +R+ T PWP D PRRAGVS+FG+ GT Sbjct 4616 IKMVMALRHGILPKTLHVDAPASQVDWTEGNVRLLTEAVPWPETDRPRRAGVSAFGVSGT 4675 Query 387 NAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGL 446 NAHVILE +P +++ + +PW L+ ++ A+ QA RLL HL + L Sbjct 4676 NAHVILE-----APARIDAEPPSEPATDGPLPWALSGKTGAAVQAQAARLLEHLESVPSL 4730 Query 447 TALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFV 506 DV WSL+++R FD RAVVVGAD L AGL +A G P GVV G R+ G+ VFV Sbjct 4731 HPADVAWSLIASRESFDQRAVVVGADHDELRAGLRAIAVGSPAPGVVRG-TRTGGRVVFV 4789 Query 507 FPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQ 566 FPGQG+QW+GM ++L VFA + E L+ + S+ V+ D L+ + Q Sbjct 4790 FPGQGAQWVGMAQELIESSPVFASSMRECAEALEPFVDWSLADVL--GDEAALQRVDVVQ 4847 Query 567 PALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGR-LMQA 625 PAL+ V V+LAA+ Q GV P V+GHS GEIAAA VAGALSL D ARVVA R R + + Sbjct 4848 PALWAVMVSLAAVWQSAGVSPSAVVGHSQGEIAAACVAGALSLSDGARVVALRSRAIAEH 4907 Query 626 LPAGGVM---VAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGR 682 L GG+M V AA+ D +A GV +AA+N P SVV+SGE A+ + G Sbjct 4908 LTGGGMMALSVPAAAARDLIAD--RPGVSLAAINGPSSVVVSGEADALDSLQAHCEEQGV 4965 Query 683 RVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVE 742 R RR+AV +A HSVL++ + + LA + + ++ +VS+VTG+ YW Sbjct 4966 RARRIAVDYASHSVLVEQIRDRLLTDLAAITPQTSKVPVVSSVTGESMDTVGWDAEYWFR 5025 Query 743 HVRKPVRFFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRPEVESVLAGV 795 ++R V F + A G V +EV P L +V L R ++ +L V Sbjct 5026 NLRNTVLFEQALTAA---GPGVIIEVSPHPVLLPAVQDIAPAVGTLRRGEGDLRRLLESV 5082 Query 796 GRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 + A GV+VDW + GRRV LPTY F QRFW Sbjct 5083 AQAHAYGVSVDWKRLVT---GRRVPLPTYAFQHQRFW 5116 Score = 71.2 bits (173), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 41/90 (46%), Positives = 55/90 (62%), Gaps = 3/90 (3%) Query 854 LQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAI 913 L +L P E ++ LVELV AA+VLG S+ I+ + F +LGFDS++ VELRN LQ Sbjct 7478 LAALPPAEREKALVELVSESAAVVLGHASAAQINAQQPFSELGFDSLTSVELRNLLQSRT 7537 Query 914 GLPGLSLPRTLIFDYPTASALAECLGQLLG 943 LSL + +FDYPT + LA L +G Sbjct 7538 ---ELSLAASAVFDYPTVTRLAAHLAGEIG 7564 Score = 70.1 bits (170), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/91 (43%), Positives = 56/91 (62%), Gaps = 3/91 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 R L+ E Q+ L++LV AA VLG S+ + + F DLGFDS++ V+LRN L+ Sbjct 5780 RFAGLSAAERQQALIDLVRESAAAVLGYGSAAQLADDQPFSDLGFDSLTAVDLRNTLRTR 5839 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLG 943 GL++P TL+FDYPT + +A L + LG Sbjct 5840 T---GLNMPATLVFDYPTVARVAGYLAEELG 5867 Score = 65.5 bits (158), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 44/110 (40%), Positives = 60/110 (55%), Gaps = 4/110 (3%) Query 830 RFWLGDNGELSVDQTGKDA-GAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDP 888 R +G + D +G G RL L+ + + LVELV AA VLG S I+ Sbjct 2631 RTLVGGTVRRTADNSGSSRDGLQERLAGLSGDQARALLVELVGDAAATVLGHASGTRINT 2690 Query 889 ECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL 938 F++LGFDS++ VELRN LQ G +LP +++FDYPT + LA L Sbjct 2691 GQPFKELGFDSLTAVELRNLLQSRT---GRALPSSVVFDYPTVTRLAAFL 2737 Score = 65.1 bits (157), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 38/100 (38%), Positives = 57/100 (57%), Gaps = 3/100 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+ + ++ L +LV AA VLG S+ ID + +F +LGFDS++ VELRN L+ Sbjct 9514 RLAGLSRADREKILTDLVRGSAATVLGHSSAGRIDTDRSFSELGFDSLTSVELRNLLRTR 9573 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDE 952 G +L ++FDYPT + LA + L S D++ Sbjct 9574 T---GRTLSSGVVFDYPTVTQLAGYVDSLFAPAEPSGDED 9610 Score = 63.5 bits (153), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/90 (44%), Positives = 51/90 (57%), Gaps = 3/90 (3%) Query 854 LQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAI 913 L +L E ++ LV+LV AA VLG SS +D + F++ GFDS++ VELRN L Sbjct 4152 LAALPSAEREQALVDLVRAAAASVLGHSSSAQVDVDQPFKEQGFDSLTAVELRNALLAGT 4211 Query 914 GLPGLSLPRTLIFDYPTASALAECLGQLLG 943 G SLP + FDYPT + LA L G Sbjct 4212 ---GTSLPASAAFDYPTVTRLAAHLSAQFG 4238 >gi|73537113|gb|AAZ77693.1| ChlA1 [Streptomyces antibioticus] Length=4699 Score = 791 bits (2043), Expect = 0.0, Method: Compositional matrix adjust. Identities = 487/1023 (48%), Positives = 611/1023 (60%), Gaps = 95/1023 (9%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGR-----------------------------EAAG 36 IA++GL+CR P P + W LL G E G Sbjct 46 IAVVGLSCRLPQASGPEEFWRLLSTGSSAVTRTLGARWAEETGLAPGTGATAAAGIEHGG 105 Query 37 SIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAM 96 +D V FDA FF +SPREA+ MDP+QRL LEL+WE LEDA +VP TLR V++GA+ Sbjct 106 VLDRVDGFDAGFFGISPREATEMDPQQRLTLELSWEALEDAAIVPGTLRSGAGGVFVGAI 165 Query 97 NDDYAVLTLAADR---VDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 DDYA L LA R H GTSR ++A RVS+ GL GPS+T+D+ QSSSLVAVHL Sbjct 166 GDDYAAL-LARHRPREFTPHTLTGTSRGLLAGRVSYTLGLHGPSLTVDAAQSSSLVAVHL 224 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 ACES+R GE LA+AGGV+L + E+ FGA+SP G Y FD RA+GYV G+GG + Sbjct 225 ACESLRGGECDLALAGGVNLIIGPESTARTAAFGALSPDGRCYTFDARANGYVRGEGGAV 284 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 V+LKP+ AL DGDRIH +IRGSAV N G S LTVPS Q +V+RRA + AG+ + Sbjct 285 VVLKPLARALADGDRIHCVIRGSAVNNDGAS-EALTVPSGRAQAEVVRRACARAGIAPDE 343 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVS--VGSVKTNIGHTGGAAGIAGLLKA 331 V YVE HGTGT++GDP+EA ALG ++ A + R + VGS KTN+GH GAAGI GL+K Sbjct 344 VQYVELHGTGTRVGDPVEAAALGSVYGAGRTRSTALRVGSAKTNVGHLEGAAGITGLVKT 403 Query 332 VLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 VL+I + + PSL++ IDLD+L LRV T PWP D P AGVSSFGMGGTN H Sbjct 404 VLSIAHRRLVPSLHFRSPHPDIDLDALRLRVQTETGPWPAPDLPLVAGVSSFGMGGTNCH 463 Query 390 VILEQGPTQSPEIVESVAAA-------GSNAPVAVPWVLAARSPQALTNQAGRLLAHLTA 442 VIL + P + +A VA+P +++AR +AL QA L + L Sbjct 464 VILAEAPAARGGEADGEGGEGCGSTPVARDAGVALPVLVSARDGEALRGQAAALESWLRK 523 Query 443 DDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGR-ARSVG 501 D+GWSL STR+ F+HRAVV+G DR L+AGL GLA G PGAGVV GR A G Sbjct 524 RPDARIADIGWSLASTRTAFEHRAVVLGQDREALLAGLRGLADGMPGAGVVQGRTAAGPG 583 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG----ADAG 557 +F GQGSQ+ GMG +L+ Y FARAFDEV A LD L +RQV++ A+AG Sbjct 584 ALAVLFTGQGSQYAGMGCELHRAYPAFARAFDEVCAHLDPLLEQPLRQVVFADEGSAEAG 643 Query 558 LLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVA 617 LL T F Q ALF V+ AL L + WGV P +V+GHS+GE+ AA+VAG LSL DAA +VA Sbjct 644 LLHRTSFTQAALFAVETALFRLFEHWGVTPQVVVGHSIGELTAAHVAGVLSLPDAAALVA 703 Query 618 ARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGEQAAVGVVV 674 ARGRLM+ALP GG MVAV ASE+EVA + E V +AA+N P SVVISG++ AV + Sbjct 704 ARGRLMEALPEGGAMVAVEASEEEVAGSVLERAGEVALAAINGPRSVVISGDEGAVTGLA 763 Query 675 DRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGY 734 ++ GR+VRRL VSHAFHS M+PM+ EF +V + P I +VSNVTG+LA AG Sbjct 764 EQWRERGRKVRRLQVSHAFHSPRMEPMLAEFERVARGLDYATPHIPVVSNVTGRLAEAGQ 823 Query 735 -GSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS---------------- 777 SP YWV HVR+ VRF DGV G +E+GPG L Sbjct 824 VDSPEYWVRHVREAVRFHDGVLALREDGVTACLELGPGGVLTGMAGECLAEEEDDTAGSG 883 Query 778 ---VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW-- 832 A L RPE ++VL + RL A GV VDW SVFA RRV LPTY F R+R+W Sbjct 884 RLLAATLRSGRPEPDAVLRALARLHAHGVPVDWRSVFAPWAPRRVALPTYAFQRRRYWPE 943 Query 833 LGD------------NGELSVDQTGKDAGAIA-----RLQSLAPPELQRQLVELVCFHAA 875 +G E+S +A + A RL + E +R L ELV A Sbjct 944 IGTGAQWPREPAETPGAEVSAGPAAHEAASTADSWQRRLAGMTGRERERFLHELVRTQVA 1003 Query 876 IVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALA 935 I LG + +D F+DLGFDSMS V+LR++L + GL LP L++++PT L Sbjct 1004 IALGHVTPDAVDTGRTFKDLGFDSMSAVQLRDQLG---AVTGLRLPAALLYNHPTPRTLV 1060 Query 936 ECL 938 + L Sbjct 1061 DRL 1063 Score = 566 bits (1460), Expect = 5e-159, Method: Compositional matrix adjust. Identities = 359/882 (41%), Positives = 500/882 (57%), Gaps = 65/882 (7%) Query 6 IAIIGLACRFPTVV-SPGDLWDLLRDGREA------------------------------ 34 IAI G+ CRFP + SP +LW L+ +G EA Sbjct 2896 IAITGIGCRFPGGIGSPEELWRLVSEGGEARSGFPSQRGWDLDALYDPDPDHPGTVYTRV 2955 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + FDADFF +SPREA A DP+QRL LE WE LE A + P +LRG V+ G Sbjct 2956 GGFLYDAHHFDADFFGMSPREALATDPQQRLLLETAWETLERAGLDPRSLRGSRTGVFTG 3015 Query 95 AMNDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 M DY L A + ++ + G+ ++ + R+++ FG GP+V++D+ SSSLVA+HL Sbjct 3016 IMYGDYGGRLQRAPEELEGYLRNGSHGSVASGRIAYTFGFEGPAVSVDTACSSSLVALHL 3075 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R GE LA+AGGV + T + +S G AF ADG +G GL Sbjct 3076 AAQALRNGECDLALAGGVTVMATPATFIEFSRQRGLSADGRCKAFAASADGTGFAEGVGL 3135 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G R+ A++RGSAV G S GLT P+ Q VI+ A++ A + Q Sbjct 3136 LLVERLSDARRNGHRVLALLRGSAVNQDGAS-NGLTAPNGPSQQRVIQAALADARLTAGQ 3194 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT +GDPIEA+AL + + +P+ +GS+K+NIGHT AAG+AG++K Sbjct 3195 VDAVEAHGTGTSLGDPIEAQALLATYGQDREPEQPLWLGSIKSNIGHTQAAAGVAGVIKM 3254 Query 332 VLAIENAVIPPSLNYVGAAIDLD----SLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 V A+ + V+P +L+ +D ++ L +T PWP PRRA VSSFG+ GTN Sbjct 3255 VQAMRHGVLPQTLHVDEPTPHVDWAAGAVALLDET--RPWPETGRPRRAAVSSFGISGTN 3312 Query 388 AHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLT 447 AHVILEQ P + E+ A PVA WVL+A++ AL QA R+ A L Sbjct 3313 AHVILEQAPLEE-STEEAPVAVSPGGPVA--WVLSAKTEGALREQAARI--RDLASGELP 3367 Query 448 ALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVF 507 DVG+SL +TR+ + RA V+ DRG +AGLA LA+G +V G A +T F+F Sbjct 3368 LADVGFSLATTRAHLEQRAAVIAEDRGGFLAGLAALASGGEHPQLVRGSAAKASRTAFLF 3427 Query 508 PGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG----ADAGLLESTE 563 GQGSQ GMGR+LY VFA+A D+V A+LD L + +RQVM+ +AGLL+ T Sbjct 3428 AGQGSQRPGMGRELYDSQPVFAQALDDVCALLDPHLDVPLRQVMFADEDSQEAGLLQDTL 3487 Query 564 FAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLM 623 + QPALF ++ AL LL+ GV P ++GHS+GEIAAA+ AG L+L DA +VAAR RL+ Sbjct 3488 YTQPALFALETALFRLLEHLGVKPHHLVGHSIGEIAAAHAAGVLTLADACTLVAARARLL 3547 Query 624 QALPAGGVMVAVAASEDEVAPLL--TEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLG 681 LPAGG M A+ A+E EV L + V IAA+NAP S VISG+ V + G Sbjct 3548 HDLPAGGAMTALQATEAEVLTALEGNDRVAIAALNAPNSTVISGDTDTVAHIAATFAEQG 3607 Query 682 RRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGA-GYGSPAYW 740 R+V L VSHAFHS +DP++++F V A + PRI ++S +TG+ AG +P YW Sbjct 3608 RKVTPLHVSHAFHSPHLDPVLDDFHTVAATLTYHQPRIPIISTLTGEPAGTDDLTTPDYW 3667 Query 741 VEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA---------SVALLARDRPEVESV 791 +R+ VRF + +L A +E+GP L A +V LL PE ++ Sbjct 3668 TRQLREAVRFHPAI---TTLDATTLIELGPDTTLTALTRSMTDAVAVPLLHPHTPETHTL 3724 Query 792 LAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 L + G +DW+++F + LPTY F +WL Sbjct 3725 LTALATAHTHGTPIDWTTIFTPHHPTAITLPTYPFQHHPYWL 3766 Score = 520 bits (1340), Expect = 5e-145, Method: Compositional matrix adjust. Identities = 355/901 (40%), Positives = 487/901 (55%), Gaps = 76/901 (8%) Query 6 IAIIGLACRFPTVV-SPGDLWDLLRDGREAAGSI-DNV---------------------- 41 + ++G+ACRFP V SP LWDL+ GR+A G + DN Sbjct 1089 VVVVGMACRFPGGVGSPEQLWDLVAQGRDAIGPLPDNRGWDLEALYDPDPETPSTSYVRE 1148 Query 42 ------AD-FDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 AD FD FF +SPREA+AMDP+QRL LE +WE LE A + P TL G V++G Sbjct 1149 GGFLYDADLFDPAFFGISPREAAAMDPQQRLLLETSWEALERAGIDPRTLAGTAAGVFVG 1208 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 A +Y L+ A+ +D + GT+ ++ + RV++ GL GP+VT+D+ SSSL A+HL Sbjct 1209 ATAQEYGPRLSEGAEGLDGYLLTGTTTSVTSGRVAYTLGLHGPAVTVDTACSSSLTALHL 1268 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R GE L +AGGV + + +SP G AF ADG +G G+ Sbjct 1269 AAQALRLGECELVLAGGVTVMAGPGMFVEFSRQRGLSPDGRCKAFAASADGTGWAEGAGM 1328 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 V+L+ + A G R+ A++RGSA+ G S GL P+ Q DVIR+A++ A + + Sbjct 1329 VVLERLSDARRHGHRVLAVVRGSAINQDGAS-NGLAAPNGPAQEDVIRQALAAARLTGDE 1387 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQRRP---VSVGSVKTNIGHTGGAAGIAGLLK 330 + VEAHGTGTK+GDPIEA AL + R R P + +GS+K+NIGH AAG+ G +K Sbjct 1388 IDAVEAHGTGTKLGDPIEAEALLATYG-RDRSPELPLWLGSLKSNIGHAQAAAGVGGFIK 1446 Query 331 AVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNA 388 V+A+ + V+P +L + +D + + + T PWP D PRRA VSSFG+ GTNA Sbjct 1447 MVMALRHGVLPGTLHADEPTPHVDWSAGTVSLLTEARPWPQTDRPRRAAVSSFGISGTNA 1506 Query 389 HVILEQGPTQS-PE---------------IVESVAAAGSNAPVAVPWVLAARSPQALTNQ 432 H+ILEQ P +S PE ESVA W ++ RS QAL Q Sbjct 1507 HLILEQAPAESAPEEGPRGPSGAVSAGAVPSESVATGAVPPESVAAWPVSGRSEQALAAQ 1566 Query 433 AGRLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGV 492 AGRL L A+ GL+ DVG+SL +TR+ F+ RAV+V ADR M LA LA GE GV Sbjct 1567 AGRLRDLLAAEPGLSPADVGYSLATTRTAFEERAVIVAADRAGFMDALAALARGESAPGV 1626 Query 493 VVGRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMW 552 V GRAR++G+TVFVFPGQGSQW GM +L VFA +E A + + S+ V+ Sbjct 1627 VRGRARALGRTVFVFPGQGSQWAGMALELLDSAPVFAERIEECAAAMSAYVDWSLVDVLR 1686 Query 553 GAD-AGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVD 611 G + A L+ + QP LF V V+LA L + +GV PD V+GHS GEIAAA VAGAL+L D Sbjct 1687 GREGAPGLDRVDVVQPVLFAVMVSLAELWRSFGVRPDAVVGHSQGEIAAACVAGALTLDD 1746 Query 612 AARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVISGEQA 668 A RVV R + + AL G MV+V EV L E + +A VN P S V+SG+ Sbjct 1747 ACRVVTLRSQALVALAGTGGMVSVPLPAAEVRARLEHRRERLGVATVNGPASTVVSGDPE 1806 Query 669 AVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQ 728 A+ + G R RR+ V +A HS ++ + E +++LA + R+ + S V G+ Sbjct 1807 ALDEFLAECAADGVRARRIPVDYASHSHHVEAIRERLAELLAGIAPRSCDVAFYSTVYGE 1866 Query 729 LAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGP----GAGLEASV------ 778 G YW ++R V F G VFVE P GL+ ++ Sbjct 1867 PVDTGELDAGYWYRNLRDTVEFERATRALLRDGYGVFVESSPHPVLTVGLQETIDAVQEV 1926 Query 779 ------ALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFW 832 L RD + +LA + + G W +V G +ELPTY F R+R W Sbjct 1927 APTVVTGSLRRDEGGLRRLLASLAEIHVNGGDAHWHTVH-GASAHTIELPTYAFQRERHW 1985 Query 833 L 833 L Sbjct 1986 L 1986 Score = 78.6 bits (192), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 47/99 (48%), Positives = 63/99 (64%), Gaps = 4/99 (4%) Query 852 ARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQM 911 ARL+SL E + ++ LV H + VLG + DI E AF+DLGFDS++ V+LRNRL Sbjct 2788 ARLESLPEAEQEELVLTLVRGHISDVLGHGGTDDIADERAFKDLGFDSLTAVDLRNRLAA 2847 Query 912 AIGLPGLSLPRTLIFDYPTASALAECL-GQLLGGQHESS 949 A G+ LP TL+FD+PT AL+ L +L G Q ES+ Sbjct 2848 AT---GVRLPATLVFDHPTPGALSRRLRAELTGSQTEST 2883 Score = 73.9 bits (180), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 42/91 (47%), Positives = 56/91 (62%), Gaps = 3/91 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 +L +LA PE L+++V HAA VLG S ++P F D+GFDS++ VELRNRL A Sbjct 4524 QLAALAEPERAEALLDVVRTHAAAVLGLASPALVEPGRGFLDMGFDSLTAVELRNRLSTA 4583 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLG 943 GL LP TL+FD+P ++LA L G Sbjct 4584 T---GLRLPATLLFDHPAPASLARHLYDAFG 4611 >gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118163848|gb|ABK64745.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=2128 Score = 783 bits (2021), Expect = 0.0, Method: Compositional matrix adjust. Identities = 452/876 (52%), Positives = 573/876 (66%), Gaps = 54/876 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +A++G+ACR+ V SP LWDL+ +GR+ Sbjct 36 VAVVGMACRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQ 95 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + DFDA FF + P EA AMDP+QR+ LE+ WE LE A + P LRG V+ G Sbjct 96 GSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSALRGTATGVFAG 155 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y ++ + G++ ++ + RVS+ GL GP+V++D+ SSSLVA+HLA Sbjct 156 VIHAGYG--GEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVDTACSSSLVAMHLA 213 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+GE LA+AGGV + +A A +E A++P G + ADG +G G+ Sbjct 214 AQSLRSGECDLALAGGVTV-MATPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGV 272 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++L+ + A G + A++RGSAV G S GLT P+ Q VIR A++ AG+ Sbjct 273 LVLERLADARRLGHPVWAVLRGSAVNQDGAS-NGLTAPNGPSQQRVIRAALANAGLSAVD 331 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VE HGTGT +GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+AG++K Sbjct 332 VDVVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKM 391 Query 332 VLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V A+ + V+P ++ + +D + + + T PWP PRRAGVSSFG+ GTNAH Sbjct 392 VQALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPEHGGPRRAGVSSFGISGTNAH 451 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ P + ++ +A VPWV++ARS +AL QA RLL H+TAD + L Sbjct 452 VIVEQAPAAAETEAAPASSTMPDA--VVPWVVSARSAEALAGQARRLLDHVTADAQASPL 509 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVGWSLVSTR+VF+HRAVVVG +RG L GLAGLA+G PG VVGRARS GKTV VFPG Sbjct 510 DVGWSLVSTRAVFEHRAVVVGRERGALATGLAGLASGRPGPATVVGRARSTGKTVLVFPG 569 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMGRQLY R+ VFA A DE VAV+D RLSVR+VMWGAD LL+STEFAQPAL Sbjct 570 QGSQTLGMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGADPELLQSTEFAQPAL 629 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 FV +VALAAL + GV PD+VMGHSVGEIAAA VAG LSL DAAR+VAARG LM ALP G Sbjct 630 FVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLRDAARLVAARGALMAALPPG 689 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAV A E +V PLL GV IAAVN P++VV+SGEQ AV V DRL G G RV RLAV Sbjct 690 GVMVAVTAGESQVGPLLGGGVSIAAVNGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAV 749 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LM+PM++ F+ A + R PRI LVSN+TGQLAG GYG+P YWV+HVR+PVR Sbjct 750 SHAFHSALMEPMLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPGYGTPQYWVDHVRRPVR 809 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGR 797 F DGV LAES GA VF+EVGPGA L + SV + + RPEV+S+L R Sbjct 810 FVDGVRLAESQGAGVFLEVGPGAALTSAVEQSLTSDRAMSVVTMPKGRPEVDSLLTAAAR 869 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 LF G V WS+ F GL RRV+LPTY FAR+RFWL Sbjct 870 LFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWL 905 Score = 94.0 bits (232), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 53/94 (57%), Positives = 67/94 (72%), Gaps = 4/94 (4%) Query 849 GAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNR 908 G ARL + P + Q +LVELVC +AA VLG S+ D+DP AF DLGFDS++ VELRNR Sbjct 1945 GLRARLAGMNPEQRQAELVELVCGNAAAVLG-HSTADVDPGDAFSDLGFDSLTAVELRNR 2003 Query 909 LQMAIGLPGLSLPRTLIFDYPTASALAECLGQLL 942 L++A GL+L T+IFD+PT +ALAE LG L Sbjct 2004 LKIAT---GLTLSPTVIFDHPTPAALAEHLGGQL 2034 >gi|29826960|ref|NP_821594.1| modular polyketide synthase [Streptomyces avermitilis MA-4680] gi|29604057|dbj|BAC68129.1| modular polyketide synthase [Streptomyces avermitilis MA-4680] Length=7746 Score = 778 bits (2008), Expect = 0.0, Method: Compositional matrix adjust. Identities = 482/1017 (48%), Positives = 613/1017 (61%), Gaps = 86/1017 (8%) Query 5 GIAIIGLACRFPTVVSPGDLWDLLRDGREA---------------------------AGS 37 GIA+IGLACR P P W LL +G +A G Sbjct 23 GIAVIGLACRLPGAADPAAFWRLLSEGADAITDVPPDRWDGAVVADASAPDRTGIRRGGF 82 Query 38 IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMN 97 +D++ DFDA FF LSP+EA+AMDP+QRL LEL WE LEDA V TLR V++GAM Sbjct 83 LDSIGDFDAGFFGLSPKEAAAMDPQQRLVLELAWEALEDAHVRAATLRSTRTGVFVGAMW 142 Query 98 DDYAVLTLAA--DRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLAC 155 DDYA L + + H G R+IIANRVS+ GL GPS+T+DSGQSSSLV+VHLAC Sbjct 143 DDYATLHHRSGLTAISPHTVTGLHRSIIANRVSYFLGLNGPSLTVDSGQSSSLVSVHLAC 202 Query 156 ESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVL 215 ES+R GE+ +A+AGGV+LN+ E+A+ +FG +SP G + FD RA+GYV G+GGG+V+ Sbjct 203 ESLRKGESTIALAGGVNLNIVPESALGAAKFGGLSPDGRCFTFDARANGYVRGEGGGIVV 262 Query 216 LKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVH 275 LKP+ A+ DGD ++ +IRGSAV N G GLTVP +GQ V+R A AGV+ V Sbjct 263 LKPLARAVADGDPVYCVIRGSAVNNDG-GGDGLTVPLQSGQEQVLRLAYERAGVNPADVG 321 Query 276 YVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 YVE HGTGTK+GDPIEA ALG + + RP+ VGS KTN+GH GAAGI GLLKAVL Sbjct 322 YVELHGTGTKVGDPIEAAALGAVLGTGREPGRPLRVGSAKTNVGHLEGAAGITGLLKAVL 381 Query 334 AIENAVIPPSLNY--VGAAIDLDSLGLRVDTALTPWPVAD-EPRRAGVSSFGMGGTNAHV 390 ++ + +P SLN+ AI LD L LRV T + W D P AGVSSFGMGGTN H+ Sbjct 382 SLNHRELPASLNFGTPNPAIPLDRLNLRVQTEHSEWAAEDGRPLLAGVSSFGMGGTNCHI 441 Query 391 ILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALD 450 +L G + A W L+A++ L QA LLAH A GL D Sbjct 442 VLASGAA----VEAGEGATAGGGAAPTFWPLSAKTASGLRAQAAALLAHTEAPLGLALPD 497 Query 451 VGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQ 510 VGWSL + R+ F+HRAVVVG R + L L+ G A + GRA G+ F+F GQ Sbjct 498 VGWSLATGRTAFEHRAVVVGEVRDDFLRALRELSTGGIDAALTTGRAGPRGELAFLFSGQ 557 Query 511 GSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG----ADAGLLESTEFAQ 566 GSQ GMGR+L FA A DEV A LD L +R+VM+ +A L+ T + Q Sbjct 558 GSQRAGMGRELAESVPAFASALDEVCAHLDPLLPRPLREVMFAPVGTGEAAELDQTLYTQ 617 Query 567 PALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQAL 626 +LF V+VAL LL+ W + PD++MGHS+GE+AAA+VAG LSL DA +VAARGRLMQAL Sbjct 618 TSLFAVEVALFRLLESWDITPDVLMGHSIGELAAAHVAGVLSLADACALVAARGRLMQAL 677 Query 627 PAGGVMVAVAASEDEVAPLL---TEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRR 683 PAGG M+AV A+EDEV + T+ V IAA+N P+SVV+SG++ + D LGR+ Sbjct 678 PAGGAMIAVQAAEDEVRARIGERTDRVSIAALNGPDSVVVSGDEDLATEIADAFAALGRK 737 Query 684 VRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAG--AGY--GSPAY 739 RL VSHAFHS M+PM+ EF V + APRI +VSNVTG+L+ +GY + AY Sbjct 738 TSRLRVSHAFHSPHMEPMLAEFRNVAEGLTFHAPRIPIVSNVTGRLSEEPSGYEGCTAAY 797 Query 740 WVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARD------------RPE 787 WV HVR+ VRF DGV + G R ++E+GPG G+ AS+A D RPE Sbjct 798 WVRHVREAVRFADGVARLDEQGVRTYLELGPG-GVLASMARAGADSESLFVPALRTRRPE 856 Query 788 VESVLAGVGRLFAEGVAVDWSSVFAGLGG--RRVELPTYGFARQRFWLGDNGELSVDQTG 845 +++LA V L GV DW ++F G G R+V LPTY F RQR+WL + V TG Sbjct 857 AQALLAAVASLHVHGVEPDWDALFGGGRGARRKVALPTYAFERQRYWLDGDTTSPVATTG 916 Query 846 -------KDA---------GAIA-RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDP 888 DA GA+ RL LA E ++++V H A VLG + ++ Sbjct 917 WAPVAPQPDAIAETDSAPVGALGRRLAGLAESERDEAVLDMVRAHIAAVLGHAEARQVET 976 Query 889 ECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL-GQLLGG 944 E F+DLGFDS+S VELRN+L A GL LP L+FD+PT +ALA L Q LGG Sbjct 977 EWTFKDLGFDSLSSVELRNQLSEAT---GLRLPSGLLFDHPTPAALARHLAAQSLGG 1030 Score = 662 bits (1709), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/877 (46%), Positives = 529/877 (61%), Gaps = 70/877 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 +AI+G++CR P V SP DLW+LL GR+A Sbjct 2554 LAIVGMSCRLPGGVQSPEDLWELLSSGRDAMSGFPTDRGWDIDALYDPDPDRPGKTYSRE 2613 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G I FDA F +SPREA AMDP+QRL LE WE E A + ++R V++G Sbjct 2614 GGFIQGADRFDAGLFGISPREALAMDPQQRLLLETAWEAFERAGIALASVRASRTGVFIG 2673 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 DYA L A + ++ +A G + ++++ R+S+ FGL GP+VT+D+ SSSLVA+HL Sbjct 2674 TNGQDYANGLRNAPEEIEGYALTGKAASVVSGRISYTFGLEGPAVTVDTACSSSLVALHL 2733 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE +A+ GGV + + + +SP G AF ADG G+G GL Sbjct 2734 AAQALRSGECSMALVGGVTVMTTPDLFVEFSRQRGLSPDGRCKAFAAGADGTGWGEGVGL 2793 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G ++ A++RGSAV G S GLT P+ Q VIR+A++ AG+ Sbjct 2794 LLVERLSDARRNGHQVLALVRGSAVNQDGAS-NGLTAPNGPSQQRVIRQALASAGLTPAD 2852 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + RPV +GSVK+NIGHT AAG+AG++K Sbjct 2853 VDAVEAHGTGTRLGDPIEAQALLATYGQEHSDDRPVWLGSVKSNIGHTQAAAGVAGVIKM 2912 Query 332 VLAIENAVIPPSLNY--VGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 VLA+ + V+P +L+ A +D + +R+ T WP PRRA VSSFG+GGTNAH Sbjct 2913 VLAMRHGVLPQTLHVDEPTAHVDWSAGAVRLLTEPVQWPGTTGPRRAAVSSFGIGGTNAH 2972 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 I+ + + A + PV VPWVL+A+S AL QA RLLA T D ++ + Sbjct 2973 TII-----EEAPAAAAAEPAREHRPVPVPWVLSAKSEVALRAQAERLLAFAT--DDVSPV 3025 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 D G+S +TRS +HRA V+G+D L AGL LAAGEP A VV GRA S K F+F G Sbjct 3026 DAGFSSATTRSALEHRAAVIGSDPAELRAGLEALAAGEPAANVVAGRAHSADKVGFLFSG 3085 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMGR+LY Y VFA A+DEV A+LD + + DA L T QPAL Sbjct 3086 QGSQRLGMGRELYAAYPVFAAAYDEVCALLDATVDV---------DAETLHQTGSTQPAL 3136 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 F V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR LM+ALPAG Sbjct 3137 FAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAALMKALPAG 3196 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAV A+EDE+ P L + IAA+N P SVVISG + AV + + GR+ RL V Sbjct 3197 GVMVAVQAAEDEMLPHLIDRAGIAAINGPRSVVISGAEDAVTAIAEVFAAQGRKTSRLKV 3256 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LMDPM+EEF++V+ + P I +VSN+TG+L + Y +P YWV HVR+ VR Sbjct 3257 SHAFHSPLMDPMLEEFAEVVRGLTFSEPWIPVVSNLTGRLTES-Y-TPEYWVRHVREAVR 3314 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALLARDRPEVESVLAGVG 796 F DGV LG FVE+GPG L A ++ L DRPE +++ Sbjct 3315 FADGVLTLHELGVTTFVEIGPGGVLSALVQGCLDDGTDIVTIPALRADRPEPQALTTAYA 3374 Query 797 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 +L G VDW + F G RRVELPTY F R+R+WL Sbjct 3375 QLHVSGAEVDWHAFFP--GARRVELPTYAFQRERYWL 3409 Score = 652 bits (1682), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/877 (45%), Positives = 532/877 (61%), Gaps = 72/877 (8%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGREA------------------------------ 34 IAI+G+ACRFP V SP DLW L+ G +A Sbjct 5974 IAIVGMACRFPGDVRSPEDLWRLVASGGDAISGFPEDRGWDVENLYDPDPDRSGKSYVRH 6033 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + A+FD FF +SPREA AMDP+QRL LE +WE E A + P T+RG V+ G Sbjct 6034 GGFLHEAAEFDPAFFGISPREALAMDPQQRLLLETSWEAFERAGIDPATVRGSRTGVFAG 6093 Query 95 AMNDDYA-VLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 M DY + A + +D + +G++ +I + RVS+ FGL GP+VT+D+ SSSLVA+HL Sbjct 6094 VMYHDYGGRVKTAPEGMDAYLGSGSAGSIASGRVSYTFGLEGPAVTVDTACSSSLVALHL 6153 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE +A+ GGV + T + +S G AF ADG +G G+ Sbjct 6154 ATQALRSGECSMALVGGVTVMATPSTFVEFSRQRGLSADGRCKAFAAGADGTGWAEGAGM 6213 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G + A++RG+AV G S GLT P+ Q VIR+A++ AGV Q Sbjct 6214 LLVERLSDARRNGHTVLAVVRGTAVNQDGAS-NGLTAPNGPSQQRVIRQALANAGVSSEQ 6272 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGTK+GDPIEA+AL + + RP+ +GS+K+NIGH AAG+ G++K Sbjct 6273 VDAVEAHGTGTKLGDPIEAQALIATYGQERPGDRPLWLGSLKSNIGHAQAAAGVGGVIKM 6332 Query 332 VLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+ + +P +L+ +D + +R+ T WP D PRRA VSSFG+ GTNAH Sbjct 6333 VMAMRHGALPRTLHVDEPTPHVDWSAGDVRLLTEAMEWPETDHPRRAAVSSFGISGTNAH 6392 Query 390 VILEQGPTQS--PEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLT 447 VI+EQ P + P + +S A VPWVL+ R+ AL QA RLL+ L + L Sbjct 6393 VIVEQAPDTAELPPVPDSGKA--------VPWVLSGRTEAALRAQAERLLS-LVPEMDLP 6443 Query 448 ALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVF 507 D+G+SL +TRS +HRA VVG R L+ GL LAAG P VV+G + GK+ F+F Sbjct 6444 PADIGFSLATTRSAMEHRAAVVGESRDELLEGLRALAAGSPSTRVVLGEPGAGGKSGFLF 6503 Query 508 PGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQP 567 GQGSQ +GMGR+LY + VFA A+DEV A++D + + D+ L T QP Sbjct 6504 SGQGSQRIGMGRELYDAFPVFAAAYDEVCALVDAPVDV---------DSEELNQTGTTQP 6554 Query 568 ALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALP 627 ALF V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR LMQALP Sbjct 6555 ALFAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAALMQALP 6614 Query 628 AGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRL 687 A G MVAV A+EDEV P LT+GV IAAVN P+SVV+SG + V + + GR+ RL Sbjct 6615 ADGAMVAVQATEDEVLPHLTDGVGIAAVNGPQSVVVSGAEDVVVAIGEAFRERGRKTSRL 6674 Query 688 AVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKP 747 VSHAFHS LMDPM+EEF++ ++ + PR+ +VSN+TG+LA Y +P YWV HVR+ Sbjct 6675 KVSHAFHSPLMDPMLEEFAEAVSGLSFNEPRLPVVSNLTGRLAEP-Y-TPEYWVRHVREA 6732 Query 748 VRFFDGVGLAESLGARVFVEVGPGAGLEA-----------SVALLARDRPEVESVLAGVG 796 VRF DG+ LG FVE+GPG L A +V + DRPE ++V+ + Sbjct 6733 VRFADGLHTLHELGVTTFVEIGPGGVLSALAQGCLDGDIVTVPAVRTDRPEPQAVVTALA 6792 Query 797 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 L A GV+ DW ++F G RRV+LPTY F +R WL Sbjct 6793 ELHAHGVSPDWRALFP--GARRVDLPTYPFQYERLWL 6827 Score = 639 bits (1647), Expect = 1e-180, Method: Compositional matrix adjust. Identities = 385/881 (44%), Positives = 531/881 (61%), Gaps = 78/881 (8%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IAI+G+ACR+P V SP DLW L+ GR+A Sbjct 4288 IAIVGMACRYPGGVQSPEDLWQLVFSGRDAVSGFPEGRGWDVEQLYDPNPDQWGTSYTRE 4347 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + ADFDA+FF +SPREA AMDP+QRL LE +WE E A + P T+RG V+ G Sbjct 4348 GGFLHDAADFDAEFFGISPREALAMDPQQRLLLETSWEAFERAGIDPATVRGSRTGVFAG 4407 Query 95 AMNDDY-AVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 M DY + + ++ + G++ +I + RVS+ FGL GP+VT+D+ SSSLVA+HL Sbjct 4408 VMYHDYGGRVHTSPPGLEGYLVNGSAGSIASGRVSYTFGLEGPAVTVDTACSSSLVALHL 4467 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE +A+ GGV + + +S G AF ADG +G G+ Sbjct 4468 AAQALRSGECSMALVGGVTVMAGPSVFVEFSRQRGLSADGRCKAFGAGADGTGWAEGVGM 4527 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G ++ A++RG+AV G S GLT P+ Q VIR+A++ AG+ + Sbjct 4528 LLVERLSDARRNGHKVLAVVRGTAVNQDGAS-NGLTAPNGPSQQRVIRQALANAGLSSDE 4586 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAAR--QRRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGH+ AAG+ G++K Sbjct 4587 VDAVEAHGTGTRLGDPIEAQALIATYGQERSEDRPLWLGSLKSNIGHSQAAAGVGGVIKM 4646 Query 332 VLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+++ V+P +L+ +D + +++ T WP +D PRRA VSSFG+ GTNAH Sbjct 4647 VMAMQHGVLPQTLHVDEPTPHVDWSAGAVQLLTEAVEWPASDGPRRAAVSSFGVSGTNAH 4706 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADD----G 445 VI+EQ T V A G+ VPWVL+A+S AL QAGRLL+ L A+ G Sbjct 4707 VIVEQAATS------EVTARGTAVAGPVPWVLSAKSDAALREQAGRLLSFLDAEGVGGAG 4760 Query 446 LTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVF 505 + DV +SL ++R+V + RA VVG + G GL G+ +G G+ F Sbjct 4761 VRPEDVAYSLATSRAVLECRAAVVGEELGEFRQGLEGIV-----SGAAPVGGAVGGRVGF 4815 Query 506 VFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFA 565 +F GQGSQ +GMGR+LY Y VFA A+DEV A+LD + + DA L T Sbjct 4816 LFSGQGSQRIGMGRELYAAYPVFAAAYDEVCALLDATVDV---------DAETLHQTGST 4866 Query 566 QPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQA 625 QPALF V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR LMQA Sbjct 4867 QPALFAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAALMQA 4926 Query 626 LPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVR 685 LPAGG MVA+ A+E EV P LT GV +AA+N P SVV+SG + AV + + GR+ Sbjct 4927 LPAGGAMVAIQATEAEVLPHLTHGVGLAAINGPRSVVLSGSEDAVLDIAEVFAQQGRKTS 4986 Query 686 RLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVR 745 RL VSHAFHS LMDPM+EEF++V+ + PRI +VSN+TG+LA P YWV HVR Sbjct 4987 RLKVSHAFHSPLMDPMLEEFAEVVRGLTFSEPRIPVVSNLTGRLAEVYI--PEYWVRHVR 5044 Query 746 KPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALLARDRPEVESVL 792 + VRF DG+ LG +FVE+GPG L A +V L DRPE +++ Sbjct 5045 EAVRFADGLHTLHELGVTMFVEIGPGGVLSALVQGCLDDGTHIVTVPALRADRPEPYALV 5104 Query 793 AGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 VG+L G++ +W ++F G RRV+LPTY F R+R+WL Sbjct 5105 TAVGQLHTHGISPEWQALFP--GARRVDLPTYAFQRERYWL 5143 Score = 620 bits (1599), Expect = 4e-175, Method: Compositional matrix adjust. Identities = 402/884 (46%), Positives = 530/884 (60%), Gaps = 81/884 (9%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IAI+ ++CR P V SP DLW LL G + Sbjct 1048 IAIVAMSCRLPGGVSSPEDLWRLLASGGDGISGFPTDRGWDVETLYDPEPGTPGKSSTRH 1107 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + A+FDA FF +SPREA+A+DP+QRL LE WE E A + P TLRG V++G Sbjct 1108 GGFLHEAAEFDAGFFGISPREAAAIDPQQRLVLETAWEAFERAGIDPATLRGSRAGVFIG 1167 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 A DY L AD V+ + GT+ ++ + RV+++FGL GP+VT+D+ SSSLVA+HL Sbjct 1168 ATAQDYGPRLHEPADGVEGYLLTGTTTSVASGRVAYSFGLEGPAVTVDTACSSSLVALHL 1227 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDG 210 A +S+R+GE +A+AGGV + T + EF +S G AF ADG +G Sbjct 1228 AVQSLRSGECTMALAGGVTV---MSTPGMFVEFSRQRGLSADGRCKAFAAGADGTGWAEG 1284 Query 211 GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVD 270 G++L++ + A +G ++ A++RGSAV G S GLT P+ Q V+R+A++ AG+ Sbjct 1285 VGMLLVERLSDARRNGHQVLAVVRGSAVNQDGAS-NGLTAPNGPSQQRVVRQALAAAGLA 1343 Query 271 CHQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGL 328 V VEAHGTGT +GDPIEA AL + + RP+ +GS+K+NIGHT AAG+AG+ Sbjct 1344 PADVDAVEAHGTGTLLGDPIEAEALIAAYGQGRDGDRPLWLGSLKSNIGHTQAAAGVAGV 1403 Query 329 LKAVLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGT 386 +K V+A+ + V+P +L+ +D + G+R+ T WP D PRRA VSSFG+ GT Sbjct 1404 IKMVMAMRHGVLPRTLHVDEPTPHVDWSASGVRLLTEAVEWPARDLPRRAAVSSFGISGT 1463 Query 387 NAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADD-- 444 NAHVI+EQ T S E A AG VPWV++A+S AL QAGRLL+ L A+ Sbjct 1464 NAHVIVEQAAT-SEEPARGTAVAGP-----VPWVVSAKSDVALREQAGRLLSFLDAEGVG 1517 Query 445 --GLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGK 502 G+ DV SL ++R+V + RA VVG D L GL LA+G +G G+ Sbjct 1518 GAGVRPEDVALSLATSRAVLERRAAVVGGDLAELRQGLEALASGA--SGAAPVGGAVGGR 1575 Query 503 TVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLEST 562 F+F GQGSQ +GMGR+LY Y VFA A+DEV A LD + + D+ L T Sbjct 1576 VGFLFSGQGSQRIGMGRELYAAYPVFAAAYDEVCAFLDAPVDV---------DSEELNQT 1626 Query 563 EFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRL 622 QPALF V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR L Sbjct 1627 GTTQPALFAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAAL 1686 Query 623 MQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGR 682 MQALP GG MVAV A+EDEV LT+GV IAAVN P SVV+SG + AV V + G GR Sbjct 1687 MQALPDGGAMVAVQATEDEVLRHLTDGVGIAAVNGPRSVVVSGAEDAVTAVGEIFAGRGR 1746 Query 683 RVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVE 742 + RL VSHAFHS LMDPM+EEF+ V+ + RI +VSN+TG+LA Y +P YWV Sbjct 1747 KTSRLKVSHAFHSPLMDPMLEEFAAVVRGLTFSESRIPVVSNLTGRLAEV-Y-TPEYWVR 1804 Query 743 HVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALLARDRPEVE 789 HVR+ VRF DG+ LG FVEVGPG L A +V +L DRPE Sbjct 1805 HVREAVRFADGIETLGELGVTTFVEVGPGGVLSALAQGCFDDGTDIVTVPVLRADRPEPY 1864 Query 790 SVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 +++ +GRL G++ DW +F G RRV+LPTY F R+R+WL Sbjct 1865 ALVTAIGRLHTHGISPDWQVLFP--GARRVDLPTYAFQRERYWL 1906 Score = 76.3 bits (186), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 40/83 (49%), Positives = 53/83 (64%), Gaps = 3/83 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL+ + E ++ +++LV A LG S + PE AFQDLGFDS++ VELRNRL A Sbjct 7575 RLEEMPEAEREKTVLDLVRAEVAAGLGHASDRTVRPEHAFQDLGFDSLTAVELRNRLNKA 7634 Query 913 IGLPGLSLPRTLIFDYPTASALA 935 GL LP TL+FD+PT + LA Sbjct 7635 T---GLRLPATLVFDHPTPALLA 7654 Score = 76.3 bits (186), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 43/96 (45%), Positives = 58/96 (61%), Gaps = 3/96 (3%) Query 851 IARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQ 910 + RL P E R L++LV AA VLG + + F++ GFDS++ VELR+RL Sbjct 2443 VQRLLGATPGEQGRILLDLVREQAATVLGHTGKGAFEADRTFRETGFDSLTAVELRHRLN 2502 Query 911 MAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQH 946 A GL LP TL+FD+PT +ALA LG+ L G+H Sbjct 2503 TAT---GLRLPTTLVFDHPTPTALARHLGEELLGRH 2535 Score = 75.5 bits (184), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 43/96 (45%), Positives = 56/96 (59%), Gaps = 3/96 (3%) Query 843 QTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSG 902 QT RL L E ++ +++LV A VLG S+ + PE AFQD GFDS++ Sbjct 5857 QTAPKGSLGQRLAGLPQAEREQVVLDLVRAEVAAVLGHASAQAVQPEHAFQDAGFDSLTS 5916 Query 903 VELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL 938 VELRNRL A GL LP T++FD+PT AL+ L Sbjct 5917 VELRNRLNAAT---GLRLPVTMVFDHPTPVALSRFL 5949 Score = 71.6 bits (174), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 40/96 (42%), Positives = 55/96 (58%), Gaps = 3/96 (3%) Query 843 QTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSG 902 QT RL LA E ++ +++LV A VLG + + + +F+D+GFDS++ Sbjct 4168 QTAPKGSLGQRLAGLAEAEREQVVLDLVRTEVAAVLGHAGAQSVGADDSFKDIGFDSLTA 4227 Query 903 VELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL 938 VELRNRL A+ G+ LP TLIFDYP LA L Sbjct 4228 VELRNRLNSAV---GMRLPATLIFDYPNPLTLAHFL 4260 >gi|15824139|dbj|BAB69303.1| modular polyketide synthase [Streptomyces avermitilis] Length=6048 Score = 777 bits (2007), Expect = 0.0, Method: Compositional matrix adjust. Identities = 482/1017 (48%), Positives = 613/1017 (61%), Gaps = 86/1017 (8%) Query 5 GIAIIGLACRFPTVVSPGDLWDLLRDGREA---------------------------AGS 37 GIA+IGLACR P P W LL +G +A G Sbjct 23 GIAVIGLACRLPGAADPAAFWRLLSEGADAITDVPPDRWDGAVVADASAPDRTGIRRGGF 82 Query 38 IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMN 97 +D++ DFDA FF LSP+EA+AMDP+QRL LEL WE LEDA V TLR V++GAM Sbjct 83 LDSIGDFDAGFFGLSPKEAAAMDPQQRLVLELAWEALEDAHVRAATLRSTRTGVFVGAMW 142 Query 98 DDYAVLTLAA--DRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLAC 155 DDYA L + + H G R+IIANRVS+ GL GPS+T+DSGQSSSLV+VHLAC Sbjct 143 DDYATLHHRSGLTAISPHTVTGLHRSIIANRVSYFLGLNGPSLTVDSGQSSSLVSVHLAC 202 Query 156 ESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVL 215 ES+R GE+ +A+AGGV+LN+ E+A+ +FG +SP G + FD RA+GYV G+GGG+V+ Sbjct 203 ESLRKGESTIALAGGVNLNIVPESALGAAKFGGLSPDGRCFTFDARANGYVRGEGGGIVV 262 Query 216 LKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVH 275 LKP+ A+ DGD ++ +IRGSAV N G GLTVP +GQ V+R A AGV+ V Sbjct 263 LKPLARAVADGDPVYCVIRGSAVNNDG-GGDGLTVPLQSGQEQVLRLAYERAGVNPADVG 321 Query 276 YVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 YVE HGTGTK+GDPIEA ALG + + RP+ VGS KTN+GH GAAGI GLLKAVL Sbjct 322 YVELHGTGTKVGDPIEAAALGAVLGTGREPGRPLRVGSAKTNVGHLEGAAGITGLLKAVL 381 Query 334 AIENAVIPPSLNY--VGAAIDLDSLGLRVDTALTPWPVAD-EPRRAGVSSFGMGGTNAHV 390 ++ + +P SLN+ AI LD L LRV T + W D P AGVSSFGMGGTN H+ Sbjct 382 SLNHRELPASLNFGTPNPAIPLDRLNLRVQTEHSEWAAEDGRPLLAGVSSFGMGGTNCHI 441 Query 391 ILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALD 450 +L G + A W L+A++ L QA LLAH A GL D Sbjct 442 VLASGAA----VEAGEGATAGGGAAPTFWPLSAKTASGLRAQAAALLAHTEAPLGLALPD 497 Query 451 VGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQ 510 VGWSL + R+ F+HRAVVVG R + L L+ G A + GRA G+ F+F GQ Sbjct 498 VGWSLATGRTAFEHRAVVVGEVRDDFLRALRELSTGGIDAALTTGRAGPRGELAFLFSGQ 557 Query 511 GSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG----ADAGLLESTEFAQ 566 GSQ GMGR+L FA A DEV A LD L +R+VM+ +A L+ T + Q Sbjct 558 GSQRAGMGRELAESVPAFASALDEVCAHLDPLLPRPLREVMFAPVGTGEAAELDQTLYTQ 617 Query 567 PALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQAL 626 +LF V+VAL LL+ W + PD++MGHS+GE+AAA+VAG LSL DA +VAARGRLMQAL Sbjct 618 TSLFAVEVALFRLLESWDITPDVLMGHSIGELAAAHVAGVLSLADACALVAARGRLMQAL 677 Query 627 PAGGVMVAVAASEDEVAPLL---TEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRR 683 PAGG M+AV A+EDEV + T+ V IAA+N P+SVV+SG++ + D LGR+ Sbjct 678 PAGGAMIAVQAAEDEVRARIGERTDRVSIAALNGPDSVVVSGDEDLATEIADAFAALGRK 737 Query 684 VRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAG--AGY--GSPAY 739 RL VSHAFHS M+PM+ EF V + APRI +VSNVTG+L+ +GY + AY Sbjct 738 TSRLRVSHAFHSPHMEPMLAEFRNVAEGLTFHAPRIPIVSNVTGRLSEEPSGYEGCTAAY 797 Query 740 WVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASVALLARD------------RPE 787 WV HVR+ VRF DGV + G R ++E+GPG G+ AS+A D RPE Sbjct 798 WVRHVREAVRFADGVARLDEQGVRTYLELGPG-GVLASMARAGADSESLFVPALRTRRPE 856 Query 788 VESVLAGVGRLFAEGVAVDWSSVFAGLGG--RRVELPTYGFARQRFWLGDNGELSVDQTG 845 +++LA V L GV DW ++F G G R+V LPTY F RQR+WL + V TG Sbjct 857 AQALLAAVASLHVHGVEPDWDALFGGGRGARRKVALPTYAFERQRYWLDGDTTSPVATTG 916 Query 846 -------KDA---------GAIA-RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDP 888 DA GA+ RL LA E ++++V H A VLG + ++ Sbjct 917 WAPVAPQPDAIAETDSAPVGALGRRLAGLAESERDEAVLDMVRAHIAAVLGHAEARQVET 976 Query 889 ECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL-GQLLGG 944 E F+DLGFDS+S VELRN+L A GL LP L+FD+PT +ALA L Q LGG Sbjct 977 EWTFKDLGFDSLSSVELRNQLSEAT---GLRLPSGLLFDHPTPAALARHLAAQSLGG 1030 Score = 662 bits (1708), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/877 (46%), Positives = 529/877 (61%), Gaps = 70/877 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 +AI+G++CR P V SP DLW+LL GR+A Sbjct 2554 LAIVGMSCRLPGGVQSPEDLWELLSSGRDAMSGFPTDRGWDIDALYDPDPDRPGKTYSRE 2613 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G I FDA F +SPREA AMDP+QRL LE WE E A + ++R V++G Sbjct 2614 GGFIQGADRFDAGLFGISPREALAMDPQQRLLLETAWEAFERAGIALASVRASRTGVFIG 2673 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 DYA L A + ++ +A G + ++++ R+S+ FGL GP+VT+D+ SSSLVA+HL Sbjct 2674 TNGQDYANGLRNAPEEIEGYALTGKAASVVSGRISYTFGLEGPAVTVDTACSSSLVALHL 2733 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE +A+ GGV + + + +SP G AF ADG G+G GL Sbjct 2734 AAQALRSGECSMALVGGVTVMTTPDLFVEFSRQRGLSPDGRCKAFAAGADGTGWGEGVGL 2793 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G ++ A++RGSAV G S GLT P+ Q VIR+A++ AG+ Sbjct 2794 LLVERLSDARRNGHQVLALVRGSAVNQDGAS-NGLTAPNGPSQQRVIRQALASAGLTPAD 2852 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + RPV +GSVK+NIGHT AAG+AG++K Sbjct 2853 VDAVEAHGTGTRLGDPIEAQALLATYGQEHSDDRPVWLGSVKSNIGHTQAAAGVAGVIKM 2912 Query 332 VLAIENAVIPPSLNY--VGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 VLA+ + V+P +L+ A +D + +R+ T WP PRRA VSSFG+GGTNAH Sbjct 2913 VLAMRHGVLPQTLHVDEPTAHVDWSAGAVRLLTEPVQWPGTTGPRRAAVSSFGIGGTNAH 2972 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 I+ + + A + PV VPWVL+A+S AL QA RLLA T D ++ + Sbjct 2973 TII-----EEAPAAAAAEPAREHRPVPVPWVLSAKSEVALRAQAERLLAFAT--DDVSPV 3025 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 D G+S +TRS +HRA V+G+D L AGL LAAGEP A VV GRA S K F+F G Sbjct 3026 DAGFSSATTRSALEHRAAVIGSDPAELRAGLEALAAGEPAANVVAGRAHSADKVGFLFSG 3085 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMGR+LY Y VFA A+DEV A+LD + + DA L T QPAL Sbjct 3086 QGSQRLGMGRELYAAYPVFAAAYDEVCALLDATVDV---------DAETLHQTGSTQPAL 3136 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 F V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR LM+ALPAG Sbjct 3137 FAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAALMKALPAG 3196 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAV A+EDE+ P L + IAA+N P SVVISG + AV + + GR+ RL V Sbjct 3197 GVMVAVQAAEDEMLPHLIDRAGIAAINGPRSVVISGAEDAVTAIAEVFAAQGRKTSRLKV 3256 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LMDPM+EEF++V+ + P I +VSN+TG+L + Y +P YWV HVR+ VR Sbjct 3257 SHAFHSPLMDPMLEEFAEVVRGLTFSEPWIPVVSNLTGRLTES-Y-TPEYWVRHVREAVR 3314 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALLARDRPEVESVLAGVG 796 F DGV LG FVE+GPG L A ++ L DRPE +++ Sbjct 3315 FADGVLTLHELGVTTFVEIGPGGVLSALVQGCLDDGTDIVTIPALRADRPEPQALTTAYA 3374 Query 797 RLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 +L G VDW + F G RRVELPTY F R+R+WL Sbjct 3375 QLHVSGAEVDWHAFFP--GARRVELPTYAFQRERYWL 3409 Score = 639 bits (1647), Expect = 1e-180, Method: Compositional matrix adjust. Identities = 385/881 (44%), Positives = 531/881 (61%), Gaps = 78/881 (8%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IAI+G+ACR+P V SP DLW L+ GR+A Sbjct 4288 IAIVGMACRYPGGVQSPEDLWQLVFSGRDAVSGFPEGRGWDVEQLYDPNPDQWGTSYTRE 4347 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + ADFDA+FF +SPREA AMDP+QRL LE +WE E A + P T+RG V+ G Sbjct 4348 GGFLHDAADFDAEFFGISPREALAMDPQQRLLLETSWEAFERAGIDPATVRGSRTGVFAG 4407 Query 95 AMNDDY-AVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 M DY + + ++ + G++ +I + RVS+ FGL GP+VT+D+ SSSLVA+HL Sbjct 4408 VMYHDYGGRVHTSPPGLEGYLVNGSAGSIASGRVSYTFGLEGPAVTVDTACSSSLVALHL 4467 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +++R+GE +A+ GGV + + +S G AF ADG +G G+ Sbjct 4468 AAQALRSGECSMALVGGVTVMAGPSVFVEFSRQRGLSADGRCKAFGAGADGTGWAEGVGM 4527 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G ++ A++RG+AV G S GLT P+ Q VIR+A++ AG+ + Sbjct 4528 LLVERLSDARRNGHKVLAVVRGTAVNQDGAS-NGLTAPNGPSQQRVIRQALANAGLSSDE 4586 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAAR--QRRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGT++GDPIEA+AL + + RP+ +GS+K+NIGH+ AAG+ G++K Sbjct 4587 VDAVEAHGTGTRLGDPIEAQALIATYGQERSEDRPLWLGSLKSNIGHSQAAAGVGGVIKM 4646 Query 332 VLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V+A+++ V+P +L+ +D + +++ T WP +D PRRA VSSFG+ GTNAH Sbjct 4647 VMAMQHGVLPQTLHVDEPTPHVDWSAGAVQLLTEAVEWPASDGPRRAAVSSFGVSGTNAH 4706 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADD----G 445 VI+EQ T V A G+ VPWVL+A+S AL QAGRLL+ L A+ G Sbjct 4707 VIVEQAATS------EVTARGTAVAGPVPWVLSAKSDAALREQAGRLLSFLDAEGVGGAG 4760 Query 446 LTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVF 505 + DV +SL ++R+V + RA VVG + G GL G+ +G G+ F Sbjct 4761 VRPEDVAYSLATSRAVLECRAAVVGEELGEFRQGLEGIV-----SGAAPVGGAVGGRVGF 4815 Query 506 VFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFA 565 +F GQGSQ +GMGR+LY Y VFA A+DEV A+LD + + DA L T Sbjct 4816 LFSGQGSQRIGMGRELYAAYPVFAAAYDEVCALLDATVDV---------DAETLHQTGST 4866 Query 566 QPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQA 625 QPALF V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR LMQA Sbjct 4867 QPALFAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAALMQA 4926 Query 626 LPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVR 685 LPAGG MVA+ A+E EV P LT GV +AA+N P SVV+SG + AV + + GR+ Sbjct 4927 LPAGGAMVAIQATEAEVLPHLTHGVGLAAINGPRSVVLSGSEDAVLDIAEVFAQQGRKTS 4986 Query 686 RLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVR 745 RL VSHAFHS LMDPM+EEF++V+ + PRI +VSN+TG+LA P YWV HVR Sbjct 4987 RLKVSHAFHSPLMDPMLEEFAEVVRGLTFSEPRIPVVSNLTGRLAEVYI--PEYWVRHVR 5044 Query 746 KPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALLARDRPEVESVL 792 + VRF DG+ LG +FVE+GPG L A +V L DRPE +++ Sbjct 5045 EAVRFADGLHTLHELGVTMFVEIGPGGVLSALVQGCLDDGTHIVTVPALRADRPEPYALV 5104 Query 793 AGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 VG+L G++ +W ++F G RRV+LPTY F R+R+WL Sbjct 5105 TAVGQLHTHGISPEWQALFP--GARRVDLPTYAFQRERYWL 5143 Score = 620 bits (1598), Expect = 5e-175, Method: Compositional matrix adjust. Identities = 402/884 (46%), Positives = 530/884 (60%), Gaps = 81/884 (9%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA------------------------------ 34 IAI+ ++CR P V SP DLW LL G + Sbjct 1048 IAIVAMSCRLPGGVSSPEDLWRLLASGGDGISGFPTDRGWDVETLYDPEPGTPGKSSTRH 1107 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + A+FDA FF +SPREA+A+DP+QRL LE WE E A + P TLRG V++G Sbjct 1108 GGFLHEAAEFDAGFFGISPREAAAIDPQQRLVLETAWEAFERAGIDPATLRGSRAGVFIG 1167 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 A DY L AD V+ + GT+ ++ + RV+++FGL GP+VT+D+ SSSLVA+HL Sbjct 1168 ATAQDYGPRLHEPADGVEGYLLTGTTTSVASGRVAYSFGLEGPAVTVDTACSSSLVALHL 1227 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDG 210 A +S+R+GE +A+AGGV + T + EF +S G AF ADG +G Sbjct 1228 AVQSLRSGECTMALAGGVTV---MSTPGMFVEFSRQRGLSADGRCKAFAAGADGTGWAEG 1284 Query 211 GGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVD 270 G++L++ + A +G ++ A++RGSAV G S GLT P+ Q V+R+A++ AG+ Sbjct 1285 VGMLLVERLSDARRNGHQVLAVVRGSAVNQDGAS-NGLTAPNGPSQQRVVRQALAAAGLA 1343 Query 271 CHQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGL 328 V VEAHGTGT +GDPIEA AL + + RP+ +GS+K+NIGHT AAG+AG+ Sbjct 1344 PADVDAVEAHGTGTLLGDPIEAEALIAAYGQGRDGDRPLWLGSLKSNIGHTQAAAGVAGV 1403 Query 329 LKAVLAIENAVIPPSLNYVGAA--IDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGT 386 +K V+A+ + V+P +L+ +D + G+R+ T WP D PRRA VSSFG+ GT Sbjct 1404 IKMVMAMRHGVLPRTLHVDEPTPHVDWSASGVRLLTEAVEWPARDLPRRAAVSSFGISGT 1463 Query 387 NAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADD-- 444 NAHVI+EQ T S E A AG VPWV++A+S AL QAGRLL+ L A+ Sbjct 1464 NAHVIVEQAAT-SEEPARGTAVAGP-----VPWVVSAKSDVALREQAGRLLSFLDAEGVG 1517 Query 445 --GLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGK 502 G+ DV SL ++R+V + RA VVG D L GL LA+G +G G+ Sbjct 1518 GAGVRPEDVALSLATSRAVLERRAAVVGGDLAELRQGLEALASGA--SGAAPVGGAVGGR 1575 Query 503 TVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLEST 562 F+F GQGSQ +GMGR+LY Y VFA A+DEV A LD + + D+ L T Sbjct 1576 VGFLFSGQGSQRIGMGRELYAAYPVFAAAYDEVCAFLDAPVDV---------DSEELNQT 1626 Query 563 EFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRL 622 QPALF V+VAL LL+ WG+ PD V GHSVGEIAAA+VAG LSL DAA++V+AR L Sbjct 1627 GTTQPALFAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAAKLVSARAAL 1686 Query 623 MQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGR 682 MQALP GG MVAV A+EDEV LT+GV IAAVN P SVV+SG + AV V + G GR Sbjct 1687 MQALPDGGAMVAVQATEDEVLRHLTDGVGIAAVNGPRSVVVSGAEDAVTAVGEIFAGRGR 1746 Query 683 RVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVE 742 + RL VSHAFHS LMDPM+EEF+ V+ + RI +VSN+TG+LA Y +P YWV Sbjct 1747 KTSRLKVSHAFHSPLMDPMLEEFAAVVRGLTFSESRIPVVSNLTGRLAEV-Y-TPEYWVR 1804 Query 743 HVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALLARDRPEVE 789 HVR+ VRF DG+ LG FVEVGPG L A +V +L DRPE Sbjct 1805 HVREAVRFADGIETLGELGVTTFVEVGPGGVLSALAQGCFDDGTDIVTVPVLRADRPEPY 1864 Query 790 SVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 +++ +GRL G++ DW +F G RRV+LPTY F R+R+WL Sbjct 1865 ALVTAIGRLHTHGISPDWQVLFP--GARRVDLPTYAFQRERYWL 1906 Score = 76.3 bits (186), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 43/96 (45%), Positives = 58/96 (61%), Gaps = 3/96 (3%) Query 851 IARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQ 910 + RL P E R L++LV AA VLG + + F++ GFDS++ VELR+RL Sbjct 2443 VQRLLGATPGEQGRILLDLVREQAATVLGHTGKGAFEADRTFRETGFDSLTAVELRHRLN 2502 Query 911 MAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQH 946 A GL LP TL+FD+PT +ALA LG+ L G+H Sbjct 2503 TAT---GLRLPTTLVFDHPTPTALARHLGEELLGRH 2535 Score = 76.3 bits (186), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 40/83 (49%), Positives = 53/83 (64%), Gaps = 3/83 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL+ + E ++ +++LV A LG S + PE AFQDLGFDS++ VELRNRL A Sbjct 5877 RLEEMPEAEREKTVLDLVRAEVAAGLGHASDRTVRPEHAFQDLGFDSLTAVELRNRLNKA 5936 Query 913 IGLPGLSLPRTLIFDYPTASALA 935 GL LP TL+FD+PT + LA Sbjct 5937 T---GLRLPATLVFDHPTPALLA 5956 Score = 71.6 bits (174), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 40/96 (42%), Positives = 55/96 (58%), Gaps = 3/96 (3%) Query 843 QTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSG 902 QT RL LA E ++ +++LV A VLG + + + +F+D+GFDS++ Sbjct 4168 QTAPKGSLGQRLAGLAEAEREQVVLDLVRTEVAAVLGHAGAQSVGADDSFKDIGFDSLTA 4227 Query 903 VELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECL 938 VELRNRL A+ G+ LP TLIFDYP LA L Sbjct 4228 VELRNRLNSAV---GMRLPATLIFDYPNPLTLAHFL 4260 >gi|183980730|ref|YP_001849021.1| polyketide synthase Pks6 [Mycobacterium marinum M] gi|183174056|gb|ACC39166.1| polyketide synthase Pks6 [Mycobacterium marinum M] Length=2414 Score = 776 bits (2003), Expect = 0.0, Method: Compositional matrix adjust. Identities = 482/1007 (48%), Positives = 608/1007 (61%), Gaps = 73/1007 (7%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGREAAGS-------------------------ID 39 IA+IG+ACRF V G LWD L + + A ++ Sbjct 107 IAVIGMACRFSGQVHGVGPLWDFLAEKKSAITEYPARRLGAAAADWLGDEQETIYGCFLE 166 Query 40 NVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDD 99 +V FD FF++ P EA+ MDP+QRL LE +W LE A ++P+TL+ V++G + D Sbjct 167 DVEGFDNKFFDIPPDEAALMDPQQRLLLETSWAALEHAGILPKTLKLSHTGVFVGVSSTD 226 Query 100 YAVLTLAADRVDH-HAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESV 158 Y L R G S +IIANR+S+ + GPS+ ID+ SSSLVA HLA +S+ Sbjct 227 YVRLLFPGGRKPTIWDNTGGSSSIIANRLSYFLDVNGPSLVIDTACSSSLVAAHLARKSL 286 Query 159 RTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKP 218 +GE LA+ G ++ ++ E QE G VSP+G AFD RADG V G+G G+V+L+ Sbjct 287 ASGECDLAVVAGTNVLISPEVWRGFQEAGVVSPTGSCRAFDARADGMVRGEGCGVVVLER 346 Query 219 VQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVE 278 + A G + A++ GSAV G S G+ P+ Q+ V+ A A +D ++ YVE Sbjct 347 LSDARRAGRTVLAVLTGSAVNQDGRS-NGIMAPNPRAQISVLDSACKCADIDPAEIDYVE 405 Query 279 AHGTGTKIGDPIEARALGEIFA-ARQR-RPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIE 336 AHGTGT +GD IEA ALG++F RQ +P+ +GS+K NIGH GAAGIAGL+K VL ++ Sbjct 406 AHGTGTSVGDRIEAHALGQVFGRGRQAAKPLMIGSIKPNIGHLEGAAGIAGLIKTVLMLQ 465 Query 337 NAVIPPS--LNYVGAAIDLDSLGLRVDTALTPWP-VADEPRRAGVSSFGMGGTNAHVILE 393 + PS I LGL V WP V PRRAGVSSFG GGTNAHVI+E Sbjct 466 RGQLLPSGAFEVPNPNIPFAELGLAVVEEFQEWPAVVGRPRRAGVSSFGFGGTNAHVIVE 525 Query 394 QGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGW 453 Q + V P + WV++AR+ + QAGRLL + A L A DVG+ Sbjct 526 QA------VERVVERVVEVGPGVLAWVVSARTAAGVGAQAGRLLEFVRAGRELDAGDVGY 579 Query 454 SLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQ 513 SLV+TRS+F+HRAVVVGA R L+AGLA + G PG GV G A GKTVFVFPGQG+Q Sbjct 580 SLVTTRSLFEHRAVVVGAGRDELLAGLAEVVEGRPGVGVASGVAMPGGKTVFVFPGQGAQ 639 Query 514 WLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQ 573 WLGMGR+L Y VFA AFD VVA LD L +R+V+WGADA LL +TEFAQPALF V+ Sbjct 640 WLGMGRELCAGYPVFAAAFDAVVAELDRHLARPLREVVWGADAELLNTTEFAQPALFAVE 699 Query 574 VALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMV 633 VAL LL+ WG+ P LVMGHSVGE++AA+V+G L L DAA +V RGRLMQALP GGVM Sbjct 700 VALYRLLESWGMRPGLVMGHSVGELSAAHVSGVLDLADAALLVVMRGRLMQALPGGGVMY 759 Query 634 AVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAF 693 AV A E E+ PLL E V +AAVN P SVV+SG + AV VVVDRL GRRVRRLAVSHAF Sbjct 760 AVQAGEQELRPLLGEQVSVAAVNGPGSVVLSGAREAVSVVVDRLAAQGRRVRRLAVSHAF 819 Query 694 HSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDG 753 HSVLM+PM+E+F V +V P I ++SNVTGQL YGS YWV H+R+ VRF D Sbjct 820 HSVLMEPMLEQFRAVADEVYAGRPAIPVISNVTGQLVAEDYGSADYWVRHIREAVRFADS 879 Query 754 VGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLFAE 801 V A S GA FVEVGP GL + +V L +DRPE +V+ V + F Sbjct 880 VCFAHSAGATRFVEVGPAGGLTSLIEESLAQVSVVAVPTLRKDRPEPFAVVGAVAQAFVR 939 Query 802 GVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN---------GELSVDQTGKDA---- 848 G VDW+SV AG GG+RV LPTY FA +RFWL D G++ D+ G A Sbjct 940 GAGVDWASVLAGCGGQRVGLPTYAFAHERFWLADRFGVGQQVCVGQVLADEAGPGAHEAA 999 Query 849 ------GAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSG 902 G ARLQ L+ E Q ++ +VC H A VLGR + +D AF D G S+S Sbjct 1000 GAAVGQGFAARLQGLSDAEQQAAVLAMVCEHTAAVLGRDGAAQLDAGQAFSDAGLTSLSA 1059 Query 903 VELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESS 949 VELRNRL+ L G++L T FDYPT + LA+ L L Q+ S+ Sbjct 1060 VELRNRLKT---LTGVTLSATTAFDYPTPTQLADHLLSHLHHQNRSA 1103 Score = 751 bits (1940), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/1010 (47%), Positives = 604/1010 (60%), Gaps = 80/1010 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 IAI+G+ CR+P V SP LW L+ G + G Sbjct 1118 IAIVGMGCRYPGGVSSPAQLWQLVASGGDVIGEFPPDRGWDIERLFDPDPDALGKTYTRH 1177 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + +VADFD FF +SP EA AMDP+QRL LE +WE LEDA + P+ LRG V++G Sbjct 1178 GGFVSDVADFDPGFFGISPGEALAMDPQQRLLLETSWEALEDAGIDPQALRGSSTGVFVG 1237 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 D Y L + +A G ++ + R+S+ GL GP++++D+ SSSLVA+HLA Sbjct 1238 IYGDGYG---LGTSQAQWYADTGHITSVASGRISYCLGLAGPAISVDTACSSSLVALHLA 1294 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLV 214 S+R GE LA+AGG + + ++ G AF + ADG +G G++ Sbjct 1295 ANSLRAGECDLALAGGSTVLATPSIFIGFSRQRGLATDGRCKAFADAADGTGFSEGAGML 1354 Query 215 LLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQV 274 +L+ + A G + AI+ GSAV G S GLT PS Q VI A+S AG+ V Sbjct 1355 VLQRLSDARRAGQPVLAILAGSAVNQDGAS-NGLTAPSGPAQQRVISAALSDAGITGADV 1413 Query 275 HYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKAV 332 VEAHGTGT++GDPIEA+AL + P+ +GS+K+N+GH+ AAG+AG++K V Sbjct 1414 DVVEAHGTGTRLGDPIEAQALLATYGRDHTPDAPLWLGSIKSNMGHSQAAAGVAGVIKMV 1473 Query 333 LAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWP-VADEPRRAGVSSFGMGGTNAH 389 A+ + ++P +L + A +D +++ T WP V PRRAGVSSFG+ GTNAH Sbjct 1474 EAMRHQLLPATLHIDQPSAHVDWSPGTVQLLTEAREWPAVVGRPRRAGVSSFGVSGTNAH 1533 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ + V P + WV++AR+ + QAGRLL + A L A Sbjct 1534 VIVEQA------VERVVERVVEVGPGVLAWVVSARTAAGVGAQAGRLLEFVRAGRELDAG 1587 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVG+SLV+TRS+F+HRAVVVGA R L+AGLA + G PG GV G A GKTVFVFPG Sbjct 1588 DVGYSLVTTRSLFEHRAVVVGAGRDELLAGLAEVVEGRPGVGVASGVAMPGGKTVFVFPG 1647 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QG+QWLGMGR+L Y VFA AFD VVA LD L +R+V+WGADA LL +TEFAQPAL Sbjct 1648 QGAQWLGMGRELCAGYPVFAAAFDAVVAELDRHLARPLREVVWGADAELLNTTEFAQPAL 1707 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 F V+VAL LL+ WG+ P LVMGHSVGE++AA+V+G L L DAA +V RGRLMQALP G Sbjct 1708 FAVEVALYRLLESWGMRPGLVMGHSVGELSAAHVSGVLDLADAALLVVMRGRLMQALPGG 1767 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVM AV A E E+ PLL E V +AAVN P SVV+SG + AV VVVDRL GRRVRRLAV Sbjct 1768 GVMYAVQAGEQELRPLLGEQVSVAAVNGPGSVVLSGAREAVSVVVDRLAAQGRRVRRLAV 1827 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHSVLM+PM+E+F V +V P I ++SNVTGQL YGS YWV H+R+ VR Sbjct 1828 SHAFHSVLMEPMLEQFRAVADEVYAGRPAIPVISNVTGQLVAEDYGSADYWVRHIREAVR 1887 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGR 797 F D V A S GA FVEVGP GL + +V L +DRPE +V+ V + Sbjct 1888 FADSVCFAHSAGATRFVEVGPAGGLTSLIEESLAQVSVVAVPTLRKDRPEPFAVVGAVAQ 1947 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN---------GELSVDQTGKDA 848 F G VDW+SV AG GG+RV LPTY FA +RFWL D G++ D+ G A Sbjct 1948 AFVRGAGVDWASVLAGCGGQRVGLPTYAFAHERFWLADRFGVGQQVCVGQVLADEAGPGA 2007 Query 849 ----------GAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD 898 G ARLQ L+ E Q ++ +VC H A VLGR + +D AF D G Sbjct 2008 HEAAGAAVGQGFAARLQGLSDAEQQAAVLAMVCEHTAAVLGRDGAAQLDAGQAFSDAGLT 2067 Query 899 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHES 948 S+S VELRNRL+ L G++L T FDYPT + LA+ L L Q+ + Sbjct 2068 SLSAVELRNRLKT---LTGVTLSATTAFDYPTPTQLADHLLSHLHHQNPT 2114 >gi|306407925|dbj|BAJ16467.1| polyketide synthase [Streptomyces graminofaciens] Length=7480 Score = 761 bits (1965), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/1007 (49%), Positives = 614/1007 (61%), Gaps = 82/1007 (8%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGR-----------------------EAAGS----- 37 IA+IGL+CR P P +LW LL DG EAAG+ Sbjct 29 IAVIGLSCRLPKASGPQELWQLLDDGASAVTRVPADRETPPSTEEESADGEAAGARWGGF 88 Query 38 IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMN 97 +D V FDA FF +SPREA+AMDP+QRL LEL+WE LE A +VP TLR + V++GA Sbjct 89 LDRVDTFDAGFFGISPREAAAMDPQQRLVLELSWEALEGAGLVPATLRDTGLGVFVGAAR 148 Query 98 DDYAVLTLAAD--RVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLAC 155 DDYA L + VDHHA G R++IANR+S+A G GPS+ +D+GQSSSLVAVHLAC Sbjct 149 DDYATLYRRREGRAVDHHAMTGLHRSLIANRISYALGAHGPSMVVDTGQSSSLVAVHLAC 208 Query 156 ESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVL 215 ES+R GE+ +A+AGGV+LN+A E+A FG +SP G + FD RA+G+V G+GGGLV+ Sbjct 209 ESLRRGESDIALAGGVNLNIAAESARETAAFGGLSPDGQCFTFDARANGFVRGEGGGLVV 268 Query 216 LKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVH 275 LK ++ AL DGD +H +I SAV N G S T LT PS Q ++ R AGV +V Sbjct 269 LKTLRRALADGDLVHGVILASAVNNDGPSDT-LTTPSRRAQESLLTRVYRRAGVTPTEVG 327 Query 276 YVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAI 335 YVE HGTGTK+GDPIEA ALG + + P+ VGS+KTNIGH GAAGIAGL+KA+L + Sbjct 328 YVELHGTGTKVGDPIEAAALGAVLGTGRDTPLPVGSIKTNIGHLEGAAGIAGLIKALLQL 387 Query 336 ENAVIPPSLNYV--GAAIDLDSLGLRVDTALTPWPVADEPRR---AGVSSFGMGGTNAHV 390 + PSLN+ I LD+L LRV PW R AGVSSFGMGGTN HV Sbjct 388 RRRRLVPSLNFSTPNPDIPLDALNLRVQQESAPWATPSGGGRTLVAGVSSFGMGGTNCHV 447 Query 391 ILEQGPTQSPEIVESVAAAGS----NAPVAVPWVLAARSPQALTNQAGRLLAHLT-ADDG 445 ++ P PE E+ + AG+ + P +PWV++ARSPQA + G T A Sbjct 448 VVSAAPV--PEDGETTSEAGATGPDSGPALLPWVVSARSPQACGTRPGDWPPGPTAAGRE 505 Query 446 LTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEP--GAGVVVGRARSVGKT 503 + +D+GWSL ++R+ F++RAVV G+DR L+A L LA+G P AG V G G+ Sbjct 506 ASPVDIGWSLATSRTHFEYRAVVSGSDRDELVASLRALASGSPVTAAGAVDGG----GRL 561 Query 504 VFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRL---------SVRQVMWGA 554 VF GQGSQ GMGR+LY + VFA AFDEV VLD + S+R+VM+ Sbjct 562 GLVFSGQGSQRAGMGRELYVAFPVFAEAFDEVCGVLDEVMGALPPSEGWAGSLREVMFEV 621 Query 555 DAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAAR 614 + LL+ T F QPALF +VAL LL+ WGV ++V GHSVGEIAA +VAG LSL DA Sbjct 622 SSDLLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAVHVAGVLSLADACA 681 Query 615 VVAARGRLMQALPAGGVMVAVAASEDEVAPLLT--EG-VCIAAVNAPESVVISGEQAAVG 671 +VAARGRLMQ LP+GG MVAV ASE+EV LL EG V I AVN P SVV+SG A V Sbjct 682 LVAARGRLMQGLPSGGAMVAVEASEEEVTALLAGREGEVGIGAVNGPRSVVVSGGVAVVE 741 Query 672 VVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAG 731 V GLGRR RRL VSHAFHS LMDPM+E+F +V+A + P + +VS +TG + Sbjct 742 EVAAHFAGLGRRARRLKVSHAFHSPLMDPMLEDFGRVVAGLSFAVPELTVVSGLTGAVVS 801 Query 732 AG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------S 777 A S YWV H R+ VRF D VG +G FVEVGPG L A Sbjct 802 ADELCSVGYWVRHAREAVRFADAVGAMAGVGVGRFVEVGPGGVLSALVRECLAEGGAGSV 861 Query 778 VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNG 837 VA + +R E ++L+ VG LFA+G VDW++ FAG RVELPTY F R R WL + Sbjct 862 VAAVRGNRAEPVALLSAVGELFADGYPVDWTAYFAGWPAARVELPTYAFQRSRHWLENVP 921 Query 838 ELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGF 897 EL+V T A+ R + + P VE V A VLG ++ D++ +F+DLGF Sbjct 922 ELAVSTTPP---AVPR-EPVTPDSDHPDPVETVRQLTAHVLGLTAAADVEMTRSFKDLGF 977 Query 898 DSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 DS+ VELR+RL A GLSL TL++D+P+ + AE + L G Sbjct 978 DSLMSVELRDRLCAAT---GLSLATTLLYDHPSPAETAEFVRARLTG 1021 Score = 639 bits (1648), Expect = 0.0, Method: Compositional matrix adjust. Identities = 410/908 (46%), Positives = 541/908 (60%), Gaps = 80/908 (8%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +AIIG++CRFP V SP +LWDL+ GR+ S Sbjct 5657 VAIIGMSCRFPGGVQSPEELWDLVAGGRDTISSFPADRGWDIDTLFDPDGERSGTSSTRY 5716 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D ADFD FF++ PREA+AMDP+QRL LE WE E A + P LRG V+ G Sbjct 5717 GAFLDGAADFDPAFFDIGPREATAMDPQQRLLLETAWEAFERAGIDPAALRGSATGVFTG 5776 Query 95 AMNDDYAVL-TLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 DYA L + AA + + G + ++I+ R+++ FGL GP++T+D+ S+SLVA+HL Sbjct 5777 TNGQDYATLASGAAAEFEGYLGIGNAGSVISGRLAYTFGLEGPAMTVDTACSASLVALHL 5836 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGG 212 A +++R GE LA+AGG + +A A +E ++P G AF ADG G+G G Sbjct 5837 AAQALRQGECSLALAGGATV-MATPGAFVEFSRQRGLAPDGRCKAFSASADGTGWGEGAG 5895 Query 213 LVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCH 272 ++LL+ + A +G I A++RGSAV G S GLT P+ Q VIR+A++ A + Sbjct 5896 MLLLERLSDAERNGHPILAVVRGSAVNQDGAS-NGLTAPNGPAQQRVIRQALANARLSAS 5954 Query 273 QVHYVEAHGTGTKIGDPIEARALGEIFAAR--QRRPVSVGSVKTNIGHTGGAAGIAGLLK 330 +V VEAHGTGTK+GDPIEA+AL + + RP+ +GSVK+N+GHT AAG+AG++K Sbjct 5955 EVDVVEAHGTGTKLGDPIEAQALLATYGQDRAEDRPLWLGSVKSNLGHTQAAAGVAGIIK 6014 Query 331 AVLAIENAVIP---------PSLNYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSF 381 +V+A+ + +P P +N+ A++L T PWP D RRA VSSF Sbjct 6015 SVMAMRHGTLPATLHVDEPTPEVNWSTGAVELL-------TESRPWPATDHVRRAAVSSF 6067 Query 382 GMGGTNAHVILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLT 441 G+ GTNAHVILEQ E ES AA +A V VPWV++ARS A+ QA RL HL Sbjct 6068 GVSGTNAHVILEQAADPVAE-AESGAALVPDA-VPVPWVVSARSADAVREQARRLHTHLM 6125 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVG 501 DVG+SL + RS F+HRAVV+G D+G L+ L LA G + V VG + G Sbjct 6126 TGREWRPADVGYSLATARSRFEHRAVVLGEDQGELLEALEALAEGRGDSRVRVGAGLAGG 6185 Query 502 KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGAD----AG 557 +T FVF GQGSQ LGMG +L + VF A+DEVVA LDG+L + +V++ + A Sbjct 6186 RTGFVFAGQGSQRLGMGGRLREMFPVFGEAWDEVVAELDGRLGRPLGEVVFAEEGSEQAS 6245 Query 558 LLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVA 617 L++ TEF QPALF +VAL LL+ WGV+PD+V GHS+GE+AAAYVAG LSL DA +V Sbjct 6246 LVDRTEFTQPALFAFEVALFRLLESWGVVPDVVAGHSIGELAAAYVAGVLSLSDACALVV 6305 Query 618 ARGRLMQALPAGGVMVAVAASEDEVAPLLTEG-----VCIAAVNAPESVVISGEQAAVGV 672 ARGRLMQALPAGG MVAV +E E A L EG V IAAVN PESVVI+G++ V Sbjct 6306 ARGRLMQALPAGGAMVAVQVTEAE-ARRLVEGEPSGAVDIAAVNGPESVVIAGDEDVVLR 6364 Query 673 VVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGA 732 V + + G GR+ +RL VSHAFHS M+PM++EF +V V PRI +VS V+G++AGA Sbjct 6365 VQEIVRGRGRKTKRLTVSHAFHSPRMEPMLDEFRRVAETVTYHEPRIAVVSAVSGEVAGA 6424 Query 733 GYGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA---------------S 777 S YW HVR+ VRF+D V S G FVEVGP L A Sbjct 6425 ELRSAEYWTRHVREAVRFYDAVRCLRSEGVSTFVEVGPDGALSALGQDCLVGEEARGTEF 6484 Query 778 VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNG 837 V+ + R E ESV+A VG GV VDW++ +A G RR +LPTY F QR+WL + Sbjct 6485 VSTVRAGRDEAESVVAAVGAAHVRGVPVDWAAYYAPYGPRRADLPTYAFEHQRYWLDTSA 6544 Query 838 ELSVDQTG 845 D TG Sbjct 6545 RPGRDATG 6552 Score = 608 bits (1569), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 401/911 (45%), Positives = 539/911 (60%), Gaps = 75/911 (8%) Query 6 IAIIGLACRFPT-VVSPGDLWDLL---------------------------RDGR---EA 34 IAI+ + CR+P V SP +LW+L+ R G Sbjct 4086 IAIVAMGCRYPGGVASPEELWELMAAEGDAISGFPTDRGWDLDALYDPDPDRAGHTYVRE 4145 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G + + A+FDA+FF +SPREASAMDP+QRL LE +WE E A + P LRG V++G Sbjct 4146 GGFLHDAAEFDAEFFGISPREASAMDPQQRLLLETSWEAFERAGIDPAALRGSATGVFVG 4205 Query 95 AMNDDYAVLTLAADRV-----DHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLV 149 + DY + + + + + H G++ ++++ R+S+ FGL GP+VT+D+ SSSLV Sbjct 4206 SNYQDYGLGSGSGSQQSSGVSEGHELIGSAPSVLSGRLSYTFGLEGPAVTVDTACSSSLV 4265 Query 150 AVHLACESVRTGEAPLAIAGGV-HLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPG 208 A+HLA +S+R GE+ LA+AGGV ++ R ++ G ++ AF +RADG Sbjct 4266 ALHLAVQSLRQGESDLALAGGVAYMANPRAFVGFSRQRG-LARDARCKAFADRADGMTLA 4324 Query 209 DGGGLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAG 268 +G GLVLL+ + A G + A++RGSA+ G S GLT P+ Q VIR+A++ A Sbjct 4325 EGVGLVLLERLSDARRLGHPVLAVVRGSAINQDGAS-NGLTAPNGPAQQRVIRQALANAR 4383 Query 269 VDCHQVHYVEAHGTGTKIGDPIEARALGEIFAAR--QRRPVSVGSVKTNIGHTGGAAGIA 326 + +V VEAHGTGT +GDPIEA+AL + + +P+ +GSVK+NIGHT AAG+A Sbjct 4384 LTPSEVDVVEAHGTGTALGDPIEAQALLATYGQERVEGQPLWLGSVKSNIGHTQAAAGVA 4443 Query 327 GLLKAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMG 384 ++K VLA+ +P +L + + +D + + + T WP PRRAGVSSFG+ Sbjct 4444 SVIKTVLAMGRGTVPATLHVDRPSSHVDWSAGAVELLTEARAWPENGHPRRAGVSSFGIS 4503 Query 385 GTNAHVILEQGPTQSPEI-VESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTAD 443 GTNAHVILEQ P +S E + + G +A VPWV++ARS +AL QAG+L A + Sbjct 4504 GTNAHVILEQAPAESGEPPQQDLPVDGESAASVVPWVVSARSVRALQAQAGQLAAWAASP 4563 Query 444 DGLTA--LDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVG 501 G A DV +L +TR+ F++R VVVG DR L+ L L+ +P A V RA + G Sbjct 4564 AGEQASPADVAQALATTRTFFEYRTVVVGGDRAELVETLRSLST-DPSAAGTVRRADTDG 4622 Query 502 --KTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRL---------SVRQV 550 + VF GQGSQ GMGR+LY + VFA AFDEV VLD + S+R+V Sbjct 4623 GGRLGLVFSGQGSQRAGMGRELYVAFPVFAEAFDEVCGVLDEVMGALPPSEGWAGSLREV 4682 Query 551 MWGADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLV 610 M+ G L+ T F QPALF +VAL LL+ WGV ++V GHSVGEIAA +VAG LSL Sbjct 4683 MFDVAGGSLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAVHVAGVLSLA 4742 Query 611 DAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT--EG-VCIAAVNAPESVVISGEQ 667 DA +VAARGRLMQ LP+GG MVAV ASE+EV LL EG V I AVN P SVV+SG Sbjct 4743 DACALVAARGRLMQGLPSGGAMVAVEASEEEVTALLAGREGEVGIGAVNGPRSVVVSGGV 4802 Query 668 AAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTG 727 A V V GLGRR RRL VSHAFHS LMDPM+E+F +V+A + P + +VS +TG Sbjct 4803 AVVEEVAAHFAGLGRRARRLKVSHAFHSPLMDPMLEDFGRVVAGLSFAVPELTVVSGLTG 4862 Query 728 QLAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA---------- 776 + A S YWV H R+ VRF D VG +G FVEVGPG L A Sbjct 4863 AVVSADELCSVGYWVRHAREAVRFADAVGAMAGVGVGRFVEVGPGGVLSALVRECLAEGG 4922 Query 777 ---SVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 VA + +R E ++++ VG LFA+G VDW++ FAG RVELPTY F R R+WL Sbjct 4923 AGSVVAAVRGNRAEPVALVSAVGELFADGYPVDWTAYFAGWPAARVELPTYAFQRSRYWL 4982 Query 834 GDNGELSVDQT 844 + +V +T Sbjct 4983 EELAGTAVRRT 4993 Score = 538 bits (1387), Expect = 2e-150, Method: Compositional matrix adjust. Identities = 368/886 (42%), Positives = 503/886 (57%), Gaps = 68/886 (7%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREA--------------------AGSIDNVADF 44 IA++ ++CRFP V +P DLW+L+RD +A G + + F Sbjct 1040 IAVVAMSCRFPGGVRTPEDLWELVRDRVDAVSVFPSDRGWNADAGLFPPAGGFLYDGHHF 1099 Query 45 DADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYA-VL 103 DA+FF +SPREA AMDP+QRL LE +WE E A + P +LRG V++GA DY L Sbjct 1100 DAEFFGISPREALAMDPQQRLLLETSWEAFERAGIDPVSLRGSRTGVFVGATAQDYTPKL 1159 Query 104 TLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEA 163 AD ++ H G + ++ + R+S+ GL GP+VT+D+ SSSLV++HLAC S+R GE Sbjct 1160 GEPADGLEGHLLTGGTVSVASGRISYFLGLEGPAVTVDTACSSSLVSLHLACRSLRQGET 1219 Query 164 PLAIAGGVHLNLARETAMLEQEF---GAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQ 220 LA+AGGV L T + EF G ++ G AF E ADG +G GLVLL+ + Sbjct 1220 TLALAGGVTL---MATPGMFAEFSRQGGLAADGRCKAFAEAADGTGWAEGVGLVLLERLS 1276 Query 221 AALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAH 280 A +G + A++RGSAV G S GLT P+ Q VIR+A++ A + V +EAH Sbjct 1277 DARRNGHPVLAVVRGSAVNQDGAS-NGLTAPNGPSQQRVIRQALADARLAPADVDLMEAH 1335 Query 281 GTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENA 338 GTGT++GDPIEA+AL + + RP+ +GSVK+NIGHT AAG+AGL+K V+A+ + Sbjct 1336 GTGTRLGDPIEAQALLATYGQGRSGDRPLWLGSVKSNIGHTQAAAGVAGLIKTVMAMRHG 1395 Query 339 VIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGP 396 +P +L + + +D + + + T PWP + PRRA VSSFG+ GTNAHVILEQ Sbjct 1396 TMPATLHVDRPSSHVDWSTGAVELLTEAQPWPDTERPRRAAVSSFGVSGTNAHVILEQA- 1454 Query 397 TQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLV 456 T+ + + A S+A VA W L+AR AL QA RL+A +T D + DVG SL Sbjct 1455 TEPAALDAAPDAIVSDAVVA--WPLSARDVGALREQAVRLVARVTGDPYVRPADVGHSLA 1512 Query 457 STRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARS--VGKTVFVFPGQGSQW 514 +TRS F+HRAVVVG +R L+AGL LA+GE A + GRA + GK VFVFPGQGSQW Sbjct 1513 ATRSSFEHRAVVVGRERAELLAGLEALASGETAANLATGRASADGAGKVVFVFPGQGSQW 1572 Query 515 LGMGRQLYGRYSVFARAFDEVVAVL------DGQLRLSVRQVMWGAD-AGLLESTEFAQP 567 GMG +L VFA ++ L DG ++ +V+ D A LE + QP Sbjct 1573 PGMGLELAAHSPVFAAVLEDCGRALAAYVDWDGH---TLHEVLAQEDGAPSLERVDVVQP 1629 Query 568 ALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALP 627 AL+ V VALAAL + GV PD V+GHS GEIAAA VAGAL+L +AA+VV+ R R + AL Sbjct 1630 ALWAVMVALAALWRSHGVQPDAVVGHSQGEIAAACVAGALTLDEAAQVVSLRSRAITALA 1689 Query 628 AGGVMVAVAASEDEVA----PLLTEG-VCIAAVNAPESVVISGEQAAVGVVVDRLVGLGR 682 G MV+V E + A P G + IAAVN P S V+SG+ AA+ +++ L Sbjct 1690 GAGQMVSVPLPEADTAEWIRPWADAGQIGIAAVNGPGSTVVSGDSAAMDELMEALAAQDV 1749 Query 683 RVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQ-LAGAGYGSPAYWV 741 R RR+ V +A HS + + +E L + R + + S VTG+ L YW Sbjct 1750 RARRIPVDYASHSPQVARIRDELLHALDGLTPRPATVPVFSTVTGEWLDDTTPMDAEYWY 1809 Query 742 EHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEASV--------------ALLARDRPE 787 ++R+ VRF + V G VF+E P L V L R + Sbjct 1810 RNLRQTVRFEEAVRALADSGCGVFIEASPHPVLTIGVQETLDVLDRTGVVTGSLRRQKGG 1869 Query 788 VESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 + L+ + ++ G VDW +VFAG G R +LPTY F R R+WL Sbjct 1870 PDRFLSSLAQVHTHGGRVDWDTVFAGTGATRTDLPTYPFQRHRYWL 1915 Score = 513 bits (1320), Expect = 1e-142, Method: Compositional matrix adjust. Identities = 350/885 (40%), Positives = 487/885 (56%), Gaps = 60/885 (6%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGREA------------------------------ 34 IAI+ ++CRFP V SP LW L+ D R+ Sbjct 2540 IAIVAMSCRFPGGVGSPEALWRLVADRRDVISGMPADRGWDIDGIYDPVPGVPGRTYTRQ 2599 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G +D V +FDA+FF +SPREA+AMDP+QRL LE +WE E A + P LRG + V++G Sbjct 2600 GGFLDGVGEFDAEFFGISPREATAMDPQQRLLLETSWEAFERAGIDPTQLRGDSVGVFVG 2659 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 DY L +D + +A G + ++ + RV++ FGL GP+VT+D+G S+SLVA+HL Sbjct 2660 CTGQDYVPRLHETSDELGGYALTGAAGSVASGRVAYTFGLEGPAVTVDTGCSASLVALHL 2719 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +S+ GE LA+AGGV + T + ++ G AF + ADG +G G+ Sbjct 2720 AVQSLSRGECSLALAGGVTVMSNPGTFIEFSRQRGLAADGRCKAFSDSADGTGWAEGVGM 2779 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G + A++RGSA+ G S GLT P+ Q VIR+A++ A + + Sbjct 2780 LLVERLSDARRNGHEVLAVVRGSAINQDGAS-NGLTAPNGRSQQRVIRQALASASLTPAE 2838 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VEAHGTGTK+GDPIEA+AL + + RP+ +G++K+NIGHT AAG+AG++K Sbjct 2839 VDVVEAHGTGTKLGDPIEAQALLATYGQDRPAERPLLLGALKSNIGHTQAAAGVAGVIKM 2898 Query 332 VLAIENAVIPPSLN--YVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 VLA+ + V P +L+ A +D + + + T PWP AD PRRAGVS+FG+GGTNAH Sbjct 2899 VLAMRHGVAPQTLHVEQPTAEVDWSAGAVELLTEARPWPDADRPRRAGVSAFGVGGTNAH 2958 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+E+ QS E A P A+PW+++ +P AL QA RLL HL A Sbjct 2959 VIIEE--AQSAPAQERTA---PEPPAALPWLVSGATPDALRAQAERLLTHLADQPETHAA 3013 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DV +SL TRS DHRA VV ADR L+AGLA LA G G+V G S + FVFPG Sbjct 3014 DVAYSLSLTRSSLDHRAAVVAADRDELLAGLAALAEGRSAPGLVRGAPHSGDRVAFVFPG 3073 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGA-DAGLLESTEFAQPA 568 QGSQW GM ++L + FA L + S+ V+ A DA L+ + QP Sbjct 3074 QGSQWPGMAQELAAAFPAFAARLRACEDALAEFVDWSLTDVLSEAPDAPPLDRVDVVQPV 3133 Query 569 LFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPA 628 L+ V V+LA L + +GV PD V+GHS GEIAAA VAGAL+L DAARVVA R + + A+ Sbjct 3134 LWAVMVSLAELWRSYGVEPDAVLGHSQGEIAAACVAGALTLQDAARVVALRSKAIVAIAG 3193 Query 629 GGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVR 685 G M++V S + + P L + + +AAVN PE+VV+SG+ AV + L G R + Sbjct 3194 QGGMLSVPLSREGLRPHLARWQDRLSVAAVNGPETVVLSGDVQAVDGLCAELQGEQIRAK 3253 Query 686 RLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVR 745 ++ V +A HS ++ + E LA + RA + S VTG YW ++R Sbjct 3254 KIQVDYASHSAHVEAIEAELFDALAPITPRAGSVPFFSTVTGDWYDTTGLDAGYWYRNLR 3313 Query 746 KPVRFFDGVGLAESLGARVFVEVGP----GAGLEASVAL----------LARDRPEVESV 791 + V G VFVE P G++ +V L RD + Sbjct 3314 QTVELHRATEALVEQGFGVFVESSPHPVLAVGMQDTVEAAGGDAVILGSLRRDDGGPDRF 3373 Query 792 LAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 L + V VDW ++F G RVELPTY F R+R+WL D Sbjct 3374 LRSLAEAHTHAVGVDWHALFTDGAGHRVELPTYAFQRKRYWLQDT 3418 Score = 86.3 bits (212), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 48/105 (46%), Positives = 64/105 (61%), Gaps = 3/105 (2%) Query 845 GKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVE 904 G+ + +RL L E Q L++L+ A VLG S IDP AF+++GFDS++ VE Sbjct 5541 GEQSSWASRLAELPAAEQQTALLDLIRGQVASVLGHASVQTIDPARAFKEIGFDSLTAVE 5600 Query 905 LRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESS 949 LRNRL A GL+LP TL+FDYPT ALAE +G + G S+ Sbjct 5601 LRNRLNAAT---GLALPTTLVFDYPTPEALAEYVGSEVLGTSSSA 5642 Score = 74.3 bits (181), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 46/119 (39%), Positives = 63/119 (53%), Gaps = 3/119 (2%) Query 835 DNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQD 894 D S G D+ + RL +L E + L +LV AA VLG ++ + ++D Sbjct 3958 DRETASATAHGTDSELVRRLNALPEDERAQALQDLVLTEAAAVLGHTTTDALGAVRPYRD 4017 Query 895 LGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDES 953 LGFDS++ VE RNRL+ A GL+LP TL+FD+PT A E L Q + G D S Sbjct 4018 LGFDSLTSVEFRNRLRDAT---GLALPATLVFDHPTPQATTEYLLQRIAGDKPIVDRAS 4073 Score = 67.4 bits (163), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 36/90 (40%), Positives = 54/90 (60%), Gaps = 3/90 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 +L L E +++L++ VC H A VLG + +DP F + G DS++ VELRNR+ Sbjct 7313 KLAGLTDAEREQELLDFVCEHTAAVLGHSGAGMVDPGRGFLEAGVDSLAAVELRNRIG-- 7370 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLL 942 G+ G+ L TL+FDYP+ LA +G+ L Sbjct 7371 -GVLGIRLSATLVFDYPSPVLLAGHIGEQL 7399 Score = 59.7 bits (143), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/84 (47%), Positives = 52/84 (62%), Gaps = 4/84 (4%) Query 861 ELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSL 920 E +R L++LV A VLG + I + F+DLGF+S+ +ELR+ L A GL L Sbjct 2438 EGRRVLLDLVRGRVADVLGHATPDTIRADRPFKDLGFNSLMTLELRSGLNEAT---GLRL 2494 Query 921 PRTLIFDYPTASALAECL-GQLLG 943 T +FD+PT SALAE L G+LLG Sbjct 2495 SATTLFDHPTPSALAEHLAGELLG 2518 >gi|183980136|ref|YP_001848427.1| polyketide synthase PKS [Mycobacterium marinum M] gi|183173462|gb|ACC38572.1| polyketide synthase PKS [Mycobacterium marinum M] Length=2444 Score = 760 bits (1962), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/876 (50%), Positives = 578/876 (66%), Gaps = 57/876 (6%) Query 6 IAIIGLACRFP-TVVSPGDLWDLLRDGREA------------------------------ 34 +AI+G+ CR+P V S G LWD++ GR+ Sbjct 638 VAIVGVGCRYPGGVESAGGLWDVVVGGRDVISGFPVDRGWDVEGVFDPDPDALGKTYCRL 697 Query 35 AGSIDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 G +D FDA FF + P EA AMDP+QRL LE +WE LEDA + P +LRG V+ G Sbjct 698 GGFLDGADRFDAGFFGIGPSEALAMDPQQRLLLECSWEALEDAGIDPVSLRGSVTGVFTG 757 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 M+ DY ++ D ++ + + ++ + RV++ GL GP+V++D+ SSSLVA+HLA Sbjct 758 LMSSDYGAGRVSGD-LEGYGLTSAAASVASGRVAYLLGLEGPAVSVDTACSSSLVALHLA 816 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLV 214 S+R+GE +A+AGGV + T + ++ G AF ADG +G G+V Sbjct 817 ASSLRSGECDVALAGGVTVMATPATFVGFSRQRGLAADGRCKAFAGAADGTGFSEGAGVV 876 Query 215 LLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQV 274 +L + A G + +I GSAV G S GLT P+ Q VI A++ AG+ V Sbjct 877 VLMRLSEARRRGLAVLGVIAGSAVNQDGAS-NGLTAPNGPAQQRVIEAALANAGLTAADV 935 Query 275 HYVEAHGTGTKIGDPIEARALGEIF--AARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAV 332 VE HGTGT +GDPIEA+AL + A +P+ +GS+K+N+GHT AAGIAG++K V Sbjct 936 DVVEGHGTGTTLGDPIEAQALLATYGQARPADQPLWLGSIKSNMGHTQAAAGIAGVIKMV 995 Query 333 LAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVAD-EPRRAGVSSFGMGGTNAH 389 A+ + ++P +L + +D S + + T PWP D PRRAGVSSFG+ GTNAH Sbjct 996 QAMRHELMPATLHVDVPSPHVDWSSGAVSLLTQPRPWPAVDGRPRRAGVSSFGISGTNAH 1055 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ PE+ VA A +P ++PWV++ +S A+ QA RLLA + AD+GL L Sbjct 1056 VIVEQ---VCPEV---VAEAVDVSPDSLPWVVSGKSEAAVAAQAKRLLAAVQADEGLDRL 1109 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVG+SL + R+ F++RAVV+G DR +L++GL LAAG+PG V+ GRA +V KTV VFPG Sbjct 1110 DVGFSL-ARRTAFEYRAVVLGEDRQQLISGLTELAAGQPGPTVLNGRAATVSKTVMVFPG 1168 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMG+QL+G++ VFA+AFD VV LD LRL +R +WG D LLESTEFAQP+L Sbjct 1169 QGSQRLGMGQQLHGQFPVFAQAFDAVVEQLDRYLRLPLRDALWGGDEHLLESTEFAQPSL 1228 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 F V+VAL ALL+DWGV PD+VMGHSVGE++AA+VAG L+L DAA++VAARGRLMQALP G Sbjct 1229 FAVEVALFALLRDWGVSPDVVMGHSVGELSAAHVAGVLTLDDAAKLVAARGRLMQALPEG 1288 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 G M A+AASE EV+PLL E V IAA+NAP++VVISGE+AAVGV+ + L+ GRRV RLAV Sbjct 1289 GAMFAIAASEHEVSPLLGEAVGIAAINAPDAVVISGERAAVGVLAEELIDRGRRVHRLAV 1348 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LM+PM+ +F+ D+ PRI LVSN+TG+LAG YGS YWVEHVR+PVR Sbjct 1349 SHAFHSPLMEPMLADFALAAGDITAHPPRIALVSNLTGELAGPDYGSAQYWVEHVRRPVR 1408 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEASVA------------LLARDRPEVESVLAGVGR 797 F D V E LGA F+EVGPG GL +++A +L +DRPEV S+++ VG+ Sbjct 1409 FADSVRNLEELGASHFIEVGPGGGLSSAIAQSLRSPEAVTVPVLGKDRPEVNSLISAVGQ 1468 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 LF+ GV VDWS+VFAG GGR+V LPTY FAR+RFWL Sbjct 1469 LFSTGVGVDWSAVFAGSGGRQVGLPTYAFARRRFWL 1504 Score = 117 bits (293), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 77/176 (44%), Positives = 98/176 (56%), Gaps = 12/176 (6%) Query 839 LSVDQTGKDAGAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFD 898 ++ D T ++G RLQ+L+P + + LVE V AA+VLGR S DIDPEC FQDLG D Sbjct 2266 INKDATTHESGLAQRLQALSPHQQHQLLVETVRNQAAVVLGRPSGQDIDPECTFQDLGLD 2325 Query 899 SMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLL------GGQHESSDDE 952 S++ VELRNRL+ A GLSL TLIFDYPT + LA L Q L G S E Sbjct 2326 SLTAVELRNRLKAA---SGLSLSPTLIFDYPTPATLARHLAQQLIGTGTTGSAQIESQLE 2382 Query 953 SIWQLLKNIPIHQLRRTGL-LDKLLLLAGQPEESLAGRTVSDEVIDSLSPEALIGL 1007 ++ Q L I +R L K L P ES GR + D + D+ SP ++ L Sbjct 2383 TLQQTLLAIEDGDKQRVAAQLRKFLTRLLAPAES--GRPLDDRIKDATSPSEILQL 2436 Score = 54.3 bits (129), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/84 (42%), Positives = 46/84 (55%), Gaps = 3/84 (3%) Query 861 ELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSL 920 E R + + V A +LG ++ ID + AF +LGFDS VELRNRL + GL L Sbjct 541 EGHRLIADTVSAEVAQILGDPAAERIDRDVAFAELGFDSRMTVELRNRLA---AVTGLRL 597 Query 921 PRTLIFDYPTASALAECLGQLLGG 944 P T+ +DY + S LA L L G Sbjct 598 PETVGWDYGSISRLAAHLETELAG 621 >gi|330467250|ref|YP_004404993.1| modular polyketide synthase [Verrucosispora maris AB-18-032] gi|328810221|gb|AEB44393.1| modular polyketide synthase [Verrucosispora maris AB-18-032] gi|340811141|gb|AEK75502.1| type 1 polyketide synthase [Verrucosispora maris AB-18-032] Length=5781 Score = 759 bits (1959), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/984 (48%), Positives = 595/984 (61%), Gaps = 71/984 (7%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGREA-----------------AGSIDNVADFDADF 48 +A++GLACR P P W LLRDGREA G +D V FDA+F Sbjct 8 VAVVGLACRLPGAADPEAFWALLRDGREAITDPPASRRDPDGRARRGGFLDAVDLFDAEF 67 Query 49 FNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAMNDDYAVL--TLA 106 F + PREA+AMDP+QRL LEL+WE LEDA + P+ L G V++GA++DDYA L Sbjct 68 FGVPPREAAAMDPQQRLVLELSWEALEDARIRPDALAGSRTGVFVGAISDDYATLLRRRG 127 Query 107 ADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACESVRTGEAPLA 166 D + H+ GT+R IIANRVS+ GL GPS+T+DS QSS+LVAVH+A ES+R GE+ LA Sbjct 128 PDAIGPHSLTGTNRGIIANRVSYHLGLHGPSITVDSAQSSALVAVHVAAESLRRGESELA 187 Query 167 IAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLLKPVQAALDDG 226 +AGGV+LNLA E+ + + FGA+SP G + FD RA+GYV G+GGGLV+LKP+ AL DG Sbjct 188 LAGGVNLNLAPESTLGAERFGALSPDGRCHTFDARANGYVRGEGGGLVVLKPLDRALADG 247 Query 227 DRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHYVEAHGTGTKI 286 DR+HA++ GSAV N G GLTVP GQ +VIR A AG +V YVE HGTGT + Sbjct 248 DRVHAVLLGSAVNNDG-VTDGLTVPGSDGQREVIRLAHERAGTTPGEVDYVELHGTGTVV 306 Query 287 GDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVLAIENAVIPPSLNY 346 GDP+EA ALG + P+ VGS KTN+GH GAAGI G +KAVL + + +PPSLN+ Sbjct 307 GDPVEAAALGAELGQLRDTPLLVGSAKTNVGHLEGAAGIVGFVKAVLCVRHRTLPPSLNF 366 Query 347 V--GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVILEQGPTQSPEIVE 404 I L+ L LRV T P P GVSSFGMGGTNAH +L + P ++ Sbjct 367 ATPNPRIPLNELNLRVVTESHTVP---RPLVVGVSSFGMGGTNAHAVLTEAPLRT----- 418 Query 405 SVAAAGSNAPVAVP--WVLAARSPQALTNQAGRLLAHLTADDGLTALDVGWSLVSTRSVF 462 A AP A P WV++ +PQAL QAG+L + L AD DV +SL +TR+ Sbjct 419 ----ARKPAPAARPLTWVVSGHTPQALRAQAGQLTS-LAADPA----DVAFSLATTRATL 469 Query 463 DHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQGSQWLGMGRQLY 522 +RA VVG L AG+A +A G P G V G G FVF GQGSQ GMGR+L Sbjct 470 PYRAAVVGETAADLRAGMAAVATGTPHPGTVTGS--PAGTLAFVFTGQGSQRAGMGRELA 527 Query 523 GRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFVVQVALAALLQD 582 R+ V+A+AF EV A LD L + +V+ ADA L+ TEFAQPALF V+VAL LL Sbjct 528 ARFPVYAQAFAEVAAALDPHLGRPLDEVLDDADA--LDRTEFAQPALFAVEVALFRLLTH 585 Query 583 WGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEV 642 WG+ PD V GHSVGEIAAA+VAG L L DAAR+VAARGRLMQALP GG MVA++A E+EV Sbjct 586 WGLRPDAVAGHSVGEIAAAHVAGVLDLPDAARLVAARGRLMQALPTGGAMVALSAGEEEV 645 Query 643 APLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMV 702 PLL G +AAVNA ESVV++G+ AV + + + G GRR RL VSHAFHS MDPM Sbjct 646 RPLLRPGADLAAVNAAESVVVAGDDDAVSAIEETVRGWGRRTSRLRVSHAFHSARMDPMR 705 Query 703 EEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFFDGVGLAESLGA 762 F++ LAD+ P I +VS +T +WV HVR VRF D V G Sbjct 706 VSFAQALADIEFAQPTIPVVSALTDP----DVTDAEHWVRHVRDTVRFADAVRDLRDRGV 761 Query 763 RVFVEVGPGAGLE---------ASVALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAG 813 R +EVGP A L A+VA+L RDRPE ++ + + F G AVDW+++ Sbjct 762 RTVLEVGPDAVLTALAHDVAELAAVAVLRRDRPEPDTAVTALATAFTRGAAVDWTAL--- 818 Query 814 LGGRR-VELPTYGFARQRFWLGDNGELSVDQTGKDAGAIARLQSLAPPELQRQLVELVCF 872 LG R+ V+LP Y F R R WL D A + R P +L++LV Sbjct 819 LGARQAVDLPRYAFQRSRHWLDQ------DNPAIAAPEVTRAPDGTPRRSDEELLDLVRT 872 Query 873 HAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTAS 932 A+ GR IDP+ F+DLG DS++ VE R+RL A G+P L L++D+PT Sbjct 873 AVAVAHGRVGPAAIDPDTTFRDLGLDSVTSVEFRDRLAAATGVP---LSPGLVYDHPTPR 929 Query 933 ALAECLGQLLGGQHESSDDESIWQ 956 A+ L L GG + ES ++ Sbjct 930 AVVAHLRTLTGGGPADPEQESGYR 953 Score = 566 bits (1459), Expect = 6e-159, Method: Compositional matrix adjust. Identities = 352/871 (41%), Positives = 483/871 (56%), Gaps = 63/871 (7%) Query 6 IAIIGLACRFPTVV-SPGDLWDLLRDGREAAGS--------------------------- 37 +A+IG+ACR+P V SP DLW L+RDGR+A G Sbjct 957 VAVIGMACRYPGGVGSPDDLWQLVRDGRDATGPFPTDRGWDLDALYDPDPGTPGRTYVRR 1016 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D A+FDADFF +SPREASAMDP+QRL L WE LE + PE+LRG V++G Sbjct 1017 GGFLDGAAEFDADFFGISPREASAMDPQQRLLLHTAWEALEHGRLNPESLRGTRTGVFVG 1076 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 +++DY L + + + GT+ ++ + RV++A GL GP+VT+D+ SSSLVA+HL Sbjct 1077 VVDNDYGPRLHEPVEGTEGYLLTGTTASVASGRVAYALGLTGPAVTVDTACSSSLVALHL 1136 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGG 212 A +++R GE LA+AGG + LA LE ++P G AF ADG +G G Sbjct 1137 AAQALRQGECTLALAGGATV-LATPGMFLEFSRQRGLAPDGRCKAFAATADGTAWAEGAG 1195 Query 213 LVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCH 272 LV+L+ + A +G + A++RGSA+ G S GLT PS Q VIRRA++ AG+ Sbjct 1196 LVVLERLSDARRNGHPVLAVLRGSAINQDGAS-NGLTAPSGPSQERVIRRALAVAGLAPS 1254 Query 273 QVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAV 332 V +EAHGTGT +GDPIEARA+ + R+ P+ +GS+K+NIGHT AAGIAG++K V Sbjct 1255 DVDLMEAHGTGTALGDPIEARAILATYGQRRDTPLHLGSLKSNIGHTQAAAGIAGVIKVV 1314 Query 333 LAIENAVIPPSLNYVGAAIDLDSLGLRVD--TALTPWPVADEPRRAGVSSFGMGGTNAHV 390 A+++ +P +L+ +D +V T TPWP PRRA VSSFG+ GTNAHV Sbjct 1315 QAMQHGTLPATLHVDEPTPHVDWAEGQVSLLTEATPWPDTGRPRRAAVSSFGISGTNAHV 1374 Query 391 ILEQG-PTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 ILE G P +P S V W+++AR P+ + QAGRL + + L Sbjct 1375 ILEHGDPQPAPPRRTSTGH--------VAWLVSAREPELVAEQAGRLHRFVRDNPELDPA 1426 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DV SL +TR + +HRA VVGADR L+AGLA L +G A + GK F+F G Sbjct 1427 DVALSLATTRPLLEHRAAVVGADRDELLAGLAELESGRRRAEAI-----RPGKVAFLFAG 1481 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QG+Q L MGRQLY FA A D V L+ L + +++G D LL TE AQPAL Sbjct 1482 QGTQRLNMGRQLYDTNPTFAHALDTVTNALNPHLNQPLLDIIFGTDPHLLNRTENAQPAL 1541 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 F ++ AL LL G+ PD ++GHS+GEI AA+ AG L+L DAA +V R +LMQ G Sbjct 1542 FAIETALYHLLTHHGIHPDYLLGHSLGEITAAHAAGILTLTDAATLVTTRAKLMQTATPG 1601 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 G M+A+ A+E E+ P L V IAA+N P + VISG+ + GRR L V Sbjct 1602 GAMIAIEATETEIQPTLHPTVTIAAINTPTTTVISGDHHHTHAIAHHWRQQGRRTTTLTV 1661 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS MDP+++ F + P L++N+TGQ +P +W H+R+PVR Sbjct 1662 SHAFHSPHMDPILDTFHTTTQTLTHHPPHTPLITNLTGQ--PLTNPTPEHWTHHLRQPVR 1719 Query 750 FFDGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRPEVESVLAGVGRLFAEG 802 + D G +E+GP L ++ RP + + A Sbjct 1720 YHDATTTLTHHGVTHTIEIGPDTTLTTLTKTNHPTLTTTPTLRPH-HNENHTLTHTLATT 1778 Query 803 VAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 +W+S++ R V LPT F R R+WL Sbjct 1779 PTTNWASLYP--HARPVRLPTTAFRRDRYWL 1807 Score = 564 bits (1454), Expect = 3e-158, Method: Compositional matrix adjust. Identities = 372/870 (43%), Positives = 489/870 (57%), Gaps = 72/870 (8%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGSIDN------------------------ 40 IAI+G+ACR+P V SP DLW L+ DG +A G Sbjct 4147 IAIVGMACRYPGGVSSPEDLWRLVADGVDAIGEFPTDRGWGEIHDPDPDRPGHSYTRHGG 4206 Query 41 ----VADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAM 96 DFDA+ F +SPREA DP+QRL LE+ WE E A + P +LRG V+ G M Sbjct 4207 FLYAAGDFDAELFGMSPREALTTDPQQRLLLEVAWEAFERAGLPPGSLRGSRTGVFTGVM 4266 Query 97 NDDY-AVLTLA---ADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVH 152 +DY A L A A + + +G++ ++ + RV+++FGL GP+VT+D+ SSSLVA+H Sbjct 4267 YNDYGARLHQAGTPAPGYEGYLVSGSAGSVASGRVAYSFGLEGPAVTVDTACSSSLVALH 4326 Query 153 LACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGG 212 LA +S+R+GE LA+AGGV + + T + ++P G F ADG +G G Sbjct 4327 LAAQSLRSGECDLALAGGVTVMASPATFVEFSRQRGLAPDGRCKPFAAAADGTGWSEGAG 4386 Query 213 LVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCH 272 L+L++ + A +G + AI+RGSAV G S GLT P+ Q VIR A++ A + Sbjct 4387 LLLVERLSDARANGHHVLAILRGSAVNQDGAS-NGLTAPNGPAQQRVIRTALTNAHLQPT 4445 Query 273 QVHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAV 332 + VEAHGTGT++GDPIEA+AL + + P+ +GS+K+NIGHT AAG+AG++K + Sbjct 4446 DIDLVEAHGTGTRLGDPIEAQALIATYGHHRNTPLHLGSLKSNIGHTQAAAGVAGVIKVI 4505 Query 333 LAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHV 390 A+++ +P +L N ++ + + T TPWP PRRA VSSFG+ GTNAHV Sbjct 4506 QAMQHGTLPATLHVNEPTPHVNWADSQVTLLTEATPWPDTGRPRRAAVSSFGISGTNAHV 4565 Query 391 ILEQGPTQSPEIVESVAAAGSNAP--VAVPWVLAARSPQALTNQAGRLLAHLTADDGLTA 448 ILE G + V++ G+ AP VPW+L+ S QALT A RLL + A Sbjct 4566 ILEHG-----DAVDTGTGTGTVAPGTAVVPWLLSGTSRQALTAYA-RLLGEVDA----AP 4615 Query 449 LDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFP 508 +D+ +L RS RA VVG DR A L +P G T F F Sbjct 4616 VDIAATLALGRSPLALRASVVGRDRPEFPT--ARLQPVQP----------VDGPTAFAFT 4663 Query 509 GQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPA 568 GQGSQ GMG L R+ FA A V LD L + V+ AD LLE TE+AQPA Sbjct 4664 GQGSQRAGMGLGLAARFPQFADALASVAEALDPHLPSPLLDVL--ADGDLLERTEYAQPA 4721 Query 569 LFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPA 628 +F V+VAL LL +GV P +++GHSVGE+AAA+VAG L L DAA +VAARGRLM L Sbjct 4722 IFAVEVALFRLLAHYGVTPHVLLGHSVGELAAAHVAGVLDLPDAATLVAARGRLMGGLVP 4781 Query 629 GGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLA 688 GG M AV A EDEV LL G IAAVNA ++VV+SG+ AV V L GRRV L Sbjct 4782 GGAMAAVRAGEDEVLALLVPGAEIAAVNADDAVVVSGDAEAVAAVTQALRDAGRRVTPLR 4841 Query 689 VSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPV 748 VSHAFHS MDP++EEF V A + P I L+S + G P YWV H+R+ V Sbjct 4842 VSHAFHSARMDPVLEEFRAVAATLRFSEPTIPLISLLPGSPT-----DPGYWVRHLREAV 4896 Query 749 RFFDGVGLAESLGARVFVEVGPGAGLE-----ASVALLARDRPEVESVLAGVGRLFAEGV 803 RF DGV G R +EVGP A L +A L RD E + + + L G Sbjct 4897 RFGDGVRSLAEWGVRRVLEVGPDAALTPVTGPTGIATLRRDHDEESAFVTALAALHDTGA 4956 Query 804 AVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 VDW++ F LG RRV LPTY F R+R+WL Sbjct 4957 TVDWATFFGELGARRVPLPTYPFQRRRYWL 4986 Score = 545 bits (1405), Expect = 1e-152, Method: Compositional matrix adjust. Identities = 341/883 (39%), Positives = 480/883 (55%), Gaps = 61/883 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGSID------------------------- 39 IAI+G+ACR+P V SP DLW L+ DG +A G Sbjct 2542 IAIVGMACRYPGGVSSPEDLWRLVADGVDAIGEFPTDRGWDLGRLYDPDPEHAGTSYTRH 2601 Query 40 -----NVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + ADFDA FF LSPREA+A DP+QRL LE+ WE E A + P +RG V+ G Sbjct 2602 GGFLYDAADFDAGFFALSPREATATDPQQRLLLEVAWEAFERAGIDPTAVRGSRTGVFAG 2661 Query 95 AMNDDYAV-LTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHL 153 M DY A + + H G + ++++ RV+++FGL GP+VT+D+ SSSLVA+HL Sbjct 2662 VMYGDYGTRWRTAPEGFEGHLLTGNTSSVVSGRVAYSFGLEGPAVTVDTACSSSLVALHL 2721 Query 154 ACESVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 A +S+R+GE LA+AGGV + T + +SP G +F A+G +G GL Sbjct 2722 AAQSLRSGECDLALAGGVTVMATPHTFVEFSRQRGLSPDGRCRSFSAAANGTGWSEGAGL 2781 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 +L++ + A +G + AI+RGSAV G S GLT P+ Q VIR A++ A + Sbjct 2782 LLVERLSDARANGHHVLAILRGSAVNQDGAS-NGLTAPNGPAQQRVIRTALTNAHLQPTD 2840 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 + VEAHGTGT++GDPIEA+AL + + P+ +GS+K+NIGHT AAG+AG++K + Sbjct 2841 IDLVEAHGTGTRLGDPIEAQALIATYGHHRNTPLHLGSLKSNIGHTQAAAGVAGVIKVIQ 2900 Query 334 AIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVI 391 A+++ +P +L N ++ + + T TPWP PRRA VSSFG+ GTNAHVI Sbjct 2901 AMQHGTLPATLHVNEPTPHVNWADSQVTLLTEATPWPDTGRPRRAAVSSFGISGTNAHVI 2960 Query 392 LEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDV 451 LE G + V ++ P VP V++ARS AL +QA R+ L + GL DV Sbjct 2961 LEHGDPRP------VPPEETDPPAPVPLVISARSAGALRDQAARVRTALGS--GLPVRDV 3012 Query 452 GWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQG 511 ++L + R+ H+AVVVG R L+AGL +A G V G + GK F+F GQG Sbjct 3013 AYTLGAARARHPHQAVVVGEGRAELLAGLDAVADG-----TVPGAVATPGKVAFLFAGQG 3067 Query 512 SQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFV 571 +Q L MGRQLY FA A D V L+ L + +++G D LL TE AQPALF Sbjct 3068 TQRLNMGRQLYDTNPTFAHALDTVTNALNPHLNQPLLDIIFGTDPHLLNRTENAQPALFA 3127 Query 572 VQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGV 631 ++ AL LL G+ PD ++GHS+GEI AA+ AG L+L DAA +V R +LMQ GG Sbjct 3128 IETALYHLLTHHGIHPDYLLGHSLGEITAAHAAGILTLTDAATLVTTRAKLMQTATPGGA 3187 Query 632 MVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSH 691 M+A+ A+E E+ P L V IAA+N P + VISG+ + GRR L VSH Sbjct 3188 MIAIEATETEIQPTLHPTVTIAAINTPTTTVISGDHHHTHAIAHHWRQQGRRTTTLTVSH 3247 Query 692 AFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFF 751 AFHS MDP+++ F + P L++N+TGQ +P +W H+R+PVR+ Sbjct 3248 AFHSPHMDPILDTFHTTTQTLTHHPPHTPLITNLTGQ--PLTNPTPEHWTHHLRQPVRYH 3305 Query 752 DGVGLAESLGARVFVEVGPGAGL-------EASVALLARDRPEVESVLAGVGRLFAEGVA 804 D G +E+GP L ++ RP + + A Sbjct 3306 DATTTLTHHGVTHTIEIGPDTTLTTLTKTNHPTLTTTPTLRPH-HNENHTLTHTLATTPT 3364 Query 805 VDWSSVFAGLGGRRVELPTYGFARQRFWL-GDNGELSVDQTGK 846 +W ++ ++LPTY F RQR+WL G + +D +G Sbjct 3365 TNWKTLLP--HATVIDLPTYPFQRQRYWLDGPAADTGLDGSGH 3405 Score = 65.1 bits (157), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 40/87 (46%), Positives = 51/87 (59%), Gaps = 4/87 (4%) Query 860 PELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLS 919 P + +L E+V A VLG S+ +D F+DLG DS+ GVELRNRL A GLP Sbjct 2444 PRDEAELREVVRSVVAEVLGYPSAAGVDSARPFRDLGLDSLGGVELRNRLAAATGLP--- 2500 Query 920 LPRTLIFDYPTASA-LAECLGQLLGGQ 945 +P TL+FD+PT A +A LG Q Sbjct 2501 VPATLVFDHPTPDAVVAHLLGATTSAQ 2527 Score = 63.2 bits (152), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 40/97 (42%), Positives = 54/97 (56%), Gaps = 4/97 (4%) Query 861 ELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSL 920 E R L+ELV VLG S + P+ DLGFDS++ VEL RL G+ Sbjct 5670 EQHRLLLELVRSTIVEVLGHSSVAAVAPDRGLMDLGFDSLTAVELAGRLGADT---GVRT 5726 Query 921 PRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQL 957 P T++FD+PT +ALA L L G+ E++DDE +L Sbjct 5727 PSTVVFDHPTPTALAHYLRHELVGE-EAADDEKPHEL 5762 Score = 55.5 bits (132), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 33/91 (37%), Positives = 47/91 (52%), Gaps = 3/91 (3%) Query 866 LVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMAIGLPGLSLPRTLI 925 L ELV A VLG + ++ + AF LG DS++ VELRNR+ GL L T++ Sbjct 4054 LRELVRAQVAAVLGHTDATEVSTDVAFTGLGLDSLTAVELRNRIAERT---GLRLSSTVV 4110 Query 926 FDYPTASALAECLGQLLGGQHESSDDESIWQ 956 FD+P+ AL + L L G + + Q Sbjct 4111 FDHPSVDALTDHLVAELAGARPVETPQPVTQ 4141 >gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342131778|gb|EGT85035.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=2121 Score = 753 bits (1945), Expect = 0.0, Method: Compositional matrix adjust. Identities = 442/879 (51%), Positives = 570/879 (65%), Gaps = 55/879 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +A++G+ACR+ V SP DLW L+ +GR+ Sbjct 36 VAVVGMACRYAGGVESPEDLWQLVIEGRDTVSDFPADRGWDVEGLYDPDPDAKGKMYTRQ 95 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + DFDA FF + P EA AMDP+QR+ LE+ WE LE A + P LRG V+ G Sbjct 96 GSFLQDAGDFDAGFFGIGPSEALAMDPQQRMMLEICWEALERAGIDPFALRGSATGVFAG 155 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y ++ + G++ ++ + RVS+ GL GP+V++D+ SSSLV++HLA Sbjct 156 VIHAGYG--GEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVDTACSSSLVSMHLA 213 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+GE LA+AGGV + +A A +E A++P G + ADG +G G+ Sbjct 214 AQSLRSGECDLALAGGVTV-MATPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGV 272 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++L+ + A G + A++RG+AV G S GLT P+ Q VIR A++ AG+ Sbjct 273 LVLERLADARRLGHPVLAVLRGTAVNQDGAS-NGLTAPNGPSQQRVIRAALANAGLAAAD 331 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VE HGTGT +GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+AG++K Sbjct 332 VDVVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKM 391 Query 332 VLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V AI + V+P +L + +D S + + T PWP RRAGVSSFG+ GTNAH Sbjct 392 VQAIRHGVMPKTLHVDVPSPHVDWTSGAVSLLTEPQPWPDHGGIRRAGVSSFGISGTNAH 451 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ P Q E VA G + PV +PWV++ARSP+AL QA RLL L+AD A+ Sbjct 452 VIVEQAPAQLDSDAEPVA--GPSNPV-IPWVISARSPEALAGQAQRLLDRLSADADARAV 508 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVGWSL + R+ F+HRAV++G DR L GLAGLA+G P G +VGR R GK VFVFPG Sbjct 509 DVGWSLATNRAAFEHRAVLIGRDREALTTGLAGLASGRPDPGALVGRTRPAGKRVFVFPG 568 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQ LGMG +LY R+ FA+AFDE VA +D RL +R+VMWG D LL+STEFAQPAL Sbjct 569 QGSQSLGMGAELYDRFPAFAQAFDEAVAAVDAHARLPLREVMWGTDPELLQSTEFAQPAL 628 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 FVV++ALAAL Q +G+ PD+V+GHSVGEIAAA VAGA+ L DAAR+VAARGRLM LPAG Sbjct 629 FVVEIALAALWQSFGITPDVVIGHSVGEIAAACVAGAMPLPDAARLVAARGRLMAGLPAG 688 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVMVAV+A+E EVA LL V IAAVN P S+V+SGE+ AVG V DRL G RV RLAV Sbjct 689 GVMVAVSATEAEVAGLLNGAVSIAAVNGPRSLVLSGERDAVGAVADRLAAGGARVHRLAV 748 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LM+PM+ EF+ V A V PRI LVSN+TGQLAG YG+ YWV+HVRKPVR Sbjct 749 SHAFHSPLMEPMMGEFAAVAAGVSAGQPRIALVSNLTGQLAGPDYGTAGYWVDHVRKPVR 808 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGR 797 F DGV LAESLGA VF+EVGPGA L + SV +A+DRPEV+S+L G+ Sbjct 809 FVDGVQLAESLGAGVFLEVGPGAALTSAVEQSLTTERATSVVSMAKDRPEVDSLLRAAGQ 868 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 LF G V W++ FA RRVELPTY F R+RFWL + Sbjct 869 LFTAGADVRWAAAFADGWARRVELPTYAFVRRRFWLSSD 907 Score = 90.5 bits (223), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 52/97 (54%), Positives = 65/97 (68%), Gaps = 4/97 (4%) Query 849 GAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNR 908 G ARL+ + P + +LVELVC +AA VLG S D++ + AF DLGFDS++ VELRNR Sbjct 1937 GLRARLEGMTPDQRHSELVELVCSNAATVLG-HSFADVNADDAFGDLGFDSLTAVELRNR 1995 Query 909 LQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGGQ 945 L++A GL+L TLIFD PT ALAE LG L G Sbjct 1996 LKIAT---GLTLSPTLIFDQPTPGALAEHLGAQLAGS 2029 >gi|49146116|ref|YP_025554.1| Type I modular polyketide synthase [Mycobacterium ulcerans Agy99] gi|42414750|emb|CAE46843.1| Type I modular polyketide synthase [Mycobacterium ulcerans Agy99] Length=14130 Score = 751 bits (1938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 441/895 (50%), Positives = 576/895 (65%), Gaps = 73/895 (8%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 1819 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 1878 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 1879 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 1938 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 1939 AWAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 1996 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 1997 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGWGEGA 2053 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 2054 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 2112 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 2113 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 2172 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 2173 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 2232 Query 388 AHVIL-------------EQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAG 434 AH+IL + P QSP ++ AG+ VPWV++A+S +AL+ QA Sbjct 2233 AHLILQQPPTPNPTQTPEDCSPAQSP--CATITDAGTGLSF-VPWVISAKSAEALSAQAS 2289 Query 435 RLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVV 494 RLL L D + A+D+GWSL++TRS+F+HRAVVVGADR +L GLA LA+G GA VVV Sbjct 2290 RLLTRLDDDPVVDAIDLGWSLIATRSMFEHRAVVVGADRHQLQRGLAELASGNLGADVVV 2349 Query 495 GRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGA 554 GRAR+ G+TV VFPGQGSQ LGMG QLY ++ VFA AFD+VV LD LRL +RQVMWG Sbjct 2350 GRARAAGETVMVFPGQGSQRLGMGAQLYEQFPVFAAAFDDVVDALDQYLRLPLRQVMWGD 2409 Query 555 DAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAAR 614 D GLL STEFAQP+LF V+VAL ALL+ WGV+PD V+GHSVGE+AAA VAG LSL DAA+ Sbjct 2410 DEGLLNSTEFAQPSLFAVEVALFALLRFWGVVPDYVIGHSVGELAAAQVAGVLSLQDAAK 2469 Query 615 VVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVV 674 +V+ARGRLMQALPAGG MVAVAAS+ EV PLL EGV IAA+NAP SVVISG+QAAV ++ Sbjct 2470 LVSARGRLMQALPAGGAMVAVAASQHEVEPLLVEGVDIAALNAPGSVVISGDQAAVRLIA 2529 Query 675 DRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGY 734 +RL G R LAVSHAFHS LM+PM+EEF+++ +++ V P+I L+SNVTGQLA A Y Sbjct 2530 NRLADRGYRAHELAVSHAFHSSLMEPMLEEFARLASEIVVEQPQIPLISNVTGQLANADY 2589 Query 735 GSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALL 781 GS YWV+H+R+PVRF D V E++GA F+EVGP +GL A SV+ L Sbjct 2590 GSAGYWVDHIRRPVRFADSVASLEAMGASCFIEVGPASGLGAAIEQSLKSAEPTVSVSAL 2649 Query 782 ARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 + D+PE +VL RL G+ VDW SVF G + V LPTY F RQRFWL N Sbjct 2650 STDKPESVAVLRAAARLSTSGIPVDWQSVFDGRSTQTVNLPTYAFQRQRFWLDAN 2704 Score = 751 bits (1938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 441/895 (50%), Positives = 576/895 (65%), Gaps = 73/895 (8%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 3358 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 3417 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 3418 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 3477 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 3478 AWAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 3535 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 3536 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGWGEGA 3592 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 3593 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 3651 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 3652 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 3711 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 3712 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 3771 Query 388 AHVIL-------------EQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAG 434 AH+IL + P QSP ++ AG+ VPWV++A+S +AL+ QA Sbjct 3772 AHLILQQPPTPNPTQTPEDCSPAQSP--CATITDAGTGLSF-VPWVISAKSAEALSAQAS 3828 Query 435 RLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVV 494 RLL L D + A+D+GWSL++TRS+F+HRAVVVGADR +L GLA LA+G GA VVV Sbjct 3829 RLLTRLDDDPVVDAIDLGWSLIATRSMFEHRAVVVGADRHQLQRGLAELASGNLGADVVV 3888 Query 495 GRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGA 554 GRAR+ G+TV VFPGQGSQ LGMG QLY ++ VFA AFD+VV LD LRL +RQVMWG Sbjct 3889 GRARAAGETVMVFPGQGSQRLGMGAQLYEQFPVFAAAFDDVVDALDQYLRLPLRQVMWGD 3948 Query 555 DAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAAR 614 D GLL STEFAQP+LF V+VAL ALL+ WGV+PD V+GHSVGE+AAA VAG LSL DAA+ Sbjct 3949 DEGLLNSTEFAQPSLFAVEVALFALLRFWGVVPDYVIGHSVGELAAAQVAGVLSLQDAAK 4008 Query 615 VVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVV 674 +V+ARGRLMQALPAGG MVAVAAS+ EV PLL EGV IAA+NAP SVVISG+QAAV ++ Sbjct 4009 LVSARGRLMQALPAGGAMVAVAASQHEVEPLLVEGVDIAALNAPGSVVISGDQAAVRLIA 4068 Query 675 DRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGY 734 +RL G R LAVSHAFHS LM+PM+EEF+++ +++ V P+I L+SNVTGQLA A Y Sbjct 4069 NRLADRGYRAHELAVSHAFHSSLMEPMLEEFARLASEIVVEQPQIPLISNVTGQLANADY 4128 Query 735 GSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALL 781 GS YWV+H+R+PVRF D V E++GA F+EVGP +GL A SV+ L Sbjct 4129 GSAGYWVDHIRRPVRFADSVASLEAMGASCFIEVGPASGLGAAIEQSLKSAEPTVSVSAL 4188 Query 782 ARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 + D+PE +VL RL G+ VDW SVF G + V LPTY F RQRFWL N Sbjct 4189 STDKPESVAVLRAAARLSTSGIPVDWQSVFDGRSTQTVNLPTYAFQRQRFWLDAN 4243 Score = 651 bits (1679), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/900 (45%), Positives = 526/900 (59%), Gaps = 75/900 (8%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGREAAGSI--------------------------- 38 +A++G++CR P P LW LLRDG I Sbjct 20 VAVVGMSCRVPGASDPDALWALLRDGISVVDEIPSARWNLDGLVAHRLTDEQRSALRHGA 79 Query 39 --DNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAM 96 D+V FDA FF ++P EA +MDP+QRL LELTW LEDA +VPE L G V+ GAM Sbjct 80 FLDDVEGFDAAFFGINPSEAGSMDPQQRLMLELTWAALEDARIVPEHLSGSSSGVFTGAM 139 Query 97 NDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACE 156 +DDY + H FAGT R++IANRVS+ GLRGPS+ ID+GQSSSLVAVH+A E Sbjct 140 SDDYTTAVTYRAAMTAHTFAGTHRSLIANRVSYTLGLRGPSLVIDTGQSSSLVAVHVAME 199 Query 157 SVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLL 216 S+R E LAIAGG+HLNL+ A+ FGA+SP G Y FD RA+GYV G+GGG+V+L Sbjct 200 SLRREETSLAIAGGIHLNLSLAAALSAAHFGALSPDGRCYTFDARANGYVRGEGGGVVVL 259 Query 217 KPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHY 276 K + AL DG+ I+ +IRGS+V N G + LT P V GQ + +A A +D +V Y Sbjct 260 KRLNDALADGNHIYCVIRGSSVNNDG-ATQDLTAPGVDGQRQALLQAYERAEIDPSEVQY 318 Query 277 VEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLA 334 VE HGTGT++GDP EA +L +F R P+ VGS+KTNIGH GAAGI GL+K LA Sbjct 319 VELHGTGTRLGDPTEAHSLHSVFGTSTVPRSPLLVGSIKTNIGHLEGAAGILGLIKTALA 378 Query 335 IENAVIPPSLNYV--GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVIL 392 + + +PPSLNY I L+ LGLRV T L+ WP D+P AGVSSF MGGTNAH+IL Sbjct 379 VHHRQLPPSLNYTVPNPKIPLEQLGLRVQTTLSEWPDLDKPLTAGVSSFSMGGTNAHLIL 438 Query 393 EQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLTADDGL 446 +Q PT S A GS+ V V W L+ARS L+ QA RL HL+A L Sbjct 439 QQPPTPDTTQTPNPTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLSAHPDL 498 Query 447 TALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVVGRA-- 497 +DV SL +TRS HRA + + + A A A G ++ R Sbjct 499 DPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLLSRGLL 558 Query 498 --RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG-- 553 + GKTVFVFPGQGSQ+ GMG LY ++ VFA A DEV A L+ L +++ +VM+ Sbjct 559 TPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDEVAAALNPHLDVALLEVMFSQQ 618 Query 554 --ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVD 611 A A LL+ T +AQPALF + AL L G+ PD ++GHS+GE+ AAY AG LSL D Sbjct 619 DTAMAQLLDQTFYAQPALFALGTALHRLFTHAGIHPDYLLGHSIGELTAAYAAGVLSLQD 678 Query 612 AARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVISGEQA 668 AA +V +RGRLMQ+ GG M+A+ ASE EV PLL V IAA+N S+V+SG+ Sbjct 679 AATLVTSRGRLMQSCTPGGTMLALQASEAEVQPLLEGLDHAVSIAAINGATSIVLSGDHD 738 Query 669 AVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQ 728 ++ + + + RR RL VSHAFHS MDP++E+F ++ A + AP + ++SN+TGQ Sbjct 739 SLEQIGEHFITQDRRTTRLQVSHAFHSPHMDPILEQFRQIAAQLTFSAPTLPILSNLTGQ 798 Query 729 LAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS---------- 777 +A SP YW + +R VRF D V G +VF+E+ P L + Sbjct 799 IARHDQLASPDYWTQQLRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTVEQAGG 858 Query 778 ----VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F QR+WL Sbjct 859 GGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQHQRYWL 916 Score = 554 bits (1427), Expect = 3e-155, Method: Compositional matrix adjust. Identities = 360/905 (40%), Positives = 504/905 (56%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 6696 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 6755 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V+ G Sbjct 6756 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFAG 6815 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G S ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 6816 AWAQSYGATN--SDDAEGYAMTGGSTSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 6873 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 6874 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 6930 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 6931 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 6989 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 6990 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 7049 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 7050 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 7109 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 7110 AHLILQQPPTPDTTQTPNPTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 7169 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 7170 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 7229 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A DEV A L+ L +++ +V Sbjct 7230 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDEVAAALNPHLDVALLEV 7289 Query 551 MWG----ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGA 606 M+ A A LL+ T +AQPALF + AL L G+ PD ++GHS+GE+ AAY AG Sbjct 7290 MFSQQDTAMAQLLDQTFYAQPALFALGTALHRLFTHAGIHPDYLLGHSIGELTAAYAAGV 7349 Query 607 LSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVI 663 LSL DAA +V +RGRLMQ+ GG M+A+ ASE EV PLL V IAA+N S+V+ Sbjct 7350 LSLQDAATLVTSRGRLMQSCTPGGTMLALQASEAEVQPLLEGLDHAVSIAAINGATSIVL 7409 Query 664 SGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVS 723 SG+ ++ + + + RR RL VSHAFHS MDP++E+F ++ A + AP + ++S Sbjct 7410 SGDHDSLEQIGEHFITQDRRTTRLQVSHAFHSPHMDPILEQFRQIAAQLTFSAPTLPILS 7469 Query 724 NVTGQLAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 N+TGQ+A SP YW + +R VRF D V G +VF+E+ P L + Sbjct 7470 NLTGQIARHDQLASPDYWTQQLRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 7529 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 7530 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 7587 Query 829 QRFWL 833 QR+WL Sbjct 7588 QRYWL 7592 Score = 553 bits (1424), Expect = 9e-155, Method: Compositional matrix adjust. Identities = 359/905 (40%), Positives = 504/905 (56%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 12093 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 12152 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V+ G Sbjct 12153 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFAG 12212 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 12213 AWAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 12270 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 12271 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 12327 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 12328 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 12386 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 12387 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 12446 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 12447 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 12506 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 12507 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 12566 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 12567 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 12626 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A DEV A L+ L +++ +V Sbjct 12627 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDEVAAALNPHLDVALLEV 12686 Query 551 MWG----ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGA 606 M+ A A LL+ T +AQPALF + AL L G+ PD ++GHS+GE+ AAY AG Sbjct 12687 MFSQQDTAMAQLLDQTFYAQPALFALGTALHRLFTHAGIHPDYLLGHSIGELTAAYAAGV 12746 Query 607 LSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVI 663 LSL DAA +V +RGRLMQ+ GG M+A+ ASE EV PLL V IAA+N S+V+ Sbjct 12747 LSLQDAATLVTSRGRLMQSCTPGGTMLALQASEAEVQPLLEGLDHAVSIAAINGATSIVL 12806 Query 664 SGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVS 723 SG+ ++ + + + RR RL VSHAFHS MDP++E+F ++ A + AP + ++S Sbjct 12807 SGDHDSLEQIGEHFITQDRRTTRLQVSHAFHSPHMDPILEQFRQIAAQLTFSAPTLPILS 12866 Query 724 NVTGQLAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 N+TGQ+A SP YW + +R VRF D V G +VF+E+ P L + Sbjct 12867 NLTGQIARHDQLASPDYWTQQLRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 12926 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 12927 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 12984 Query 829 QRFWL 833 QR+WL Sbjct 12985 QRYWL 12989 Score = 482 bits (1240), Expect = 2e-133, Method: Compositional matrix adjust. Identities = 338/905 (38%), Positives = 477/905 (53%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 8495 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 8554 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V+ G Sbjct 8555 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFAG 8614 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 8615 AWAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 8672 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 8673 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 8729 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 8730 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 8788 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 8789 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 8848 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 8849 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 8908 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 8909 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 8968 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 8969 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 9028 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L SV V Sbjct 9029 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTGWSVLAV 9088 Query 551 MWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSL 609 + +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+VAGAL+L Sbjct 9089 LHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHVAGALTL 9148 Query 610 VDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGE 666 +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S V+SG+ Sbjct 9149 PEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPASAVVSGD 9208 Query 667 QAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVT 726 A+ ++ R + V + HS M+ + +F L ++ R I + S V Sbjct 9209 TTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIAMYSTVD 9268 Query 727 GQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 G+ Y + YW ++R VRF D V G +VF+E+ P L + Sbjct 9269 GEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 9328 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 9329 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 9386 Query 829 QRFWL 833 QR+WL Sbjct 9387 QRYWL 9391 Score = 482 bits (1240), Expect = 2e-133, Method: Compositional matrix adjust. Identities = 338/905 (38%), Positives = 477/905 (53%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 10294 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 10353 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V+ G Sbjct 10354 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFAG 10413 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 10414 AWAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 10471 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 10472 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 10528 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 10529 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 10587 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 10588 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 10647 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 10648 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 10707 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 10708 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 10767 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 10768 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 10827 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L SV V Sbjct 10828 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTGWSVLAV 10887 Query 551 MWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSL 609 + +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+VAGAL+L Sbjct 10888 LHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHVAGALTL 10947 Query 610 VDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGE 666 +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S V+SG+ Sbjct 10948 PEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPASAVVSGD 11007 Query 667 QAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVT 726 A+ ++ R + V + HS M+ + +F L ++ R I + S V Sbjct 11008 TTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIAMYSTVD 11067 Query 727 GQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 G+ Y + YW ++R VRF D V G +VF+E+ P L + Sbjct 11068 GEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 11127 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 11128 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 11185 Query 829 QRFWL 833 QR+WL Sbjct 11186 QRYWL 11190 Score = 481 bits (1238), Expect = 3e-133, Method: Compositional matrix adjust. Identities = 337/905 (38%), Positives = 477/905 (53%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 4897 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 4956 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 4957 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 5016 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 5017 AWAQSYGATN--SDDAEGYAMTGGAISVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 5074 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+ GGV T + EF ++P G AF ADG G+G Sbjct 5075 CQSLRNNESQLALTGGV---TVMSTPAIFTEFSRQRGLAPDGRCKAFAATADGTGWGEGA 5131 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 5132 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 5190 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 5191 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 5250 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 5251 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 5310 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 5311 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 5370 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 5371 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 5430 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L SV V Sbjct 5431 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTGWSVLAV 5490 Query 551 MWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSL 609 + +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+VAGAL+L Sbjct 5491 LHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHVAGALTL 5550 Query 610 VDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGE 666 +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S V+SG+ Sbjct 5551 PEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPASAVVSGD 5610 Query 667 QAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVT 726 A+ ++ R + V + HS M+ + +F L ++ R I + S V Sbjct 5611 TTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIAMYSTVD 5670 Query 727 GQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 G+ Y + YW ++R VRF D V G +VF+E+ P L + Sbjct 5671 GEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 5730 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 5731 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 5788 Query 829 QRFWL 833 QR+WL Sbjct 5789 QRYWL 5793 Score = 73.6 bits (179), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/170 (33%), Positives = 86/170 (51%), Gaps = 30/170 (17%) Query 782 ARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE-LS 840 A DRP+ +A +V+W + PT+ AR R +L + E ++ Sbjct 3192 AIDRPQATLTVA----------SVNWDRFY----------PTFALARPRPFLHEITEVMA 3231 Query 841 VDQTGKDAGA------IARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQD 894 ++ + + A ++L L E + +LV AA VLG S+ +D +F+D Sbjct 3232 YRESMRSSSASTATLLTSKLAGLTATEQRAVTRKLVLDQAASVLGYASTESLDTHESFKD 3291 Query 895 LGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 LGFDS++ +ELR+ LQ A GL+L TLIFD+PT A+AE L + + G Sbjct 3292 LGFDSLTALELRDHLQTAT---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 3338 Score = 73.6 bits (179), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/170 (33%), Positives = 86/170 (51%), Gaps = 30/170 (17%) Query 782 ARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE-LS 840 A DRP+ +A +V+W + PT+ AR R +L + E ++ Sbjct 4731 AIDRPQATLTVA----------SVNWDRFY----------PTFALARPRPFLHEITEVMA 4770 Query 841 VDQTGKDAGA------IARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQD 894 ++ + + A ++L L E + +LV AA VLG S+ +D +F+D Sbjct 4771 YRESMRSSSASTATLLTSKLAGLTATEQRAVTRKLVLDQAASVLGYASTESLDTHESFKD 4830 Query 895 LGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 LGFDS++ +ELR+ LQ A GL+L TLIFD+PT A+AE L + + G Sbjct 4831 LGFDSLTALELRDHLQTAT---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 4877 Score = 60.5 bits (145), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/92 (46%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 6588 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 6647 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL LP TLIFD+PT A+AE L + + G Sbjct 6648 T---GLDLPPTLIFDHPTPHAVAEHLLEQIPG 6676 Score = 60.5 bits (145), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/92 (46%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 8387 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 8446 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL LP TLIFD+PT A+AE L + + G Sbjct 8447 T---GLDLPPTLIFDHPTPHAVAEHLLEQIPG 8475 Score = 60.5 bits (145), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/92 (46%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 10186 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 10245 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL LP TLIFD+PT A+AE L + + G Sbjct 10246 T---GLDLPPTLIFDHPTPHAVAEHLLEQIPG 10274 Score = 60.5 bits (145), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/92 (46%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 11985 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 12044 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL LP TLIFD+PT A+AE L + + G Sbjct 12045 T---GLDLPPTLIFDHPTPHAVAEHLLEQIPG 12073 Score = 60.5 bits (145), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/94 (45%), Positives = 52/94 (56%), Gaps = 3/94 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 13784 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 13843 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGGQH 946 GL LP TLIFD+PT AL + L L H Sbjct 13844 T---GLDLPPTLIFDHPTPHALTQHLHTRLTQSH 13874 Score = 58.2 bits (139), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 41/92 (45%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 1711 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 1770 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL+L TLIFD+PT A+AE L + + G Sbjct 1771 T---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 1799 >gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=2131 Score = 749 bits (1934), Expect = 0.0, Method: Compositional matrix adjust. Identities = 436/879 (50%), Positives = 578/879 (66%), Gaps = 56/879 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +A++G+ACR+ V +P LW+L+ +GR+ Sbjct 49 VAVVGMACRYAGGVDTPDALWELVAEGRDTVSDFPLDRGWDVEGLYDPDPDAKGKMYTRH 108 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 + + DFDA FF + P EA AMDP+QR+ LE+ WE LE A + P LRG V+ G Sbjct 109 GSFLQHAGDFDAGFFGIGPSEALAMDPQQRMMLEICWEALERAGIDPFALRGTATGVFAG 168 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y ++ + G++ ++ + RVS+ GL GP+V++D+ SSSLV++HLA Sbjct 169 VIHAGYG--GEVKGELEGYGLTGSTLSVTSGRVSYVLGLEGPAVSVDTACSSSLVSMHLA 226 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+GE LA+AGGV + +A A +E A++P G + ADG +G G+ Sbjct 227 AQSLRSGECDLALAGGVTV-MATPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGV 285 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++L+ + A G + A++RG+AV G S GLT P+ Q VIR A++ AG+ Sbjct 286 LVLERLADARRLGHPVLALLRGTAVNQDGAS-NGLTAPNGPSQQRVIRAALANAGLTAAD 344 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKA 331 V VE HGTGT +GDPIEA+AL + + RP+ +GS+K+NIGHT AAG+AG++K Sbjct 345 VDAVEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKM 404 Query 332 VLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAH 389 V A+ + V+P +L + +D + + + T PWP PRRAGVSSFG+ GTNAH Sbjct 405 VQAMRHGVLPRTLHVDVPSPHVDWSAGAVSLLTDPRPWPDHGGPRRAGVSSFGISGTNAH 464 Query 390 VILEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTAL 449 VI+EQ P + ++ A GSN P+ VPWV++ARS AL QA RLL HL A + A+ Sbjct 465 VIVEQAPAEPNDV--PAAHDGSN-PI-VPWVVSARSTDALAGQAQRLLDHLGATPDVPAV 520 Query 450 DVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPG 509 DVGWSL +TR+ F+HRAV++GADR L AGLAGLAAG P G + GR R+ GK VFVFPG Sbjct 521 DVGWSLATTRAAFEHRAVLIGADRAGLSAGLAGLAAGAPVPGAITGRTRAAGKRVFVFPG 580 Query 510 QGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPAL 569 QGSQWLGMG LY R+ FA+AFDE +D RL +R+VMWG+DA LL+STEFAQPAL Sbjct 581 QGSQWLGMGAALYERFPAFAQAFDETETAVDAHCRLPLREVMWGSDAELLQSTEFAQPAL 640 Query 570 FVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAG 629 F +++A+AAL + GV PD+V+GHSVGEIAAA VAGALSL DAAR+VA+RGRLM LP G Sbjct 641 FALEIAMAALWESLGVTPDVVIGHSVGEIAAACVAGALSLSDAARLVASRGRLMAQLPPG 700 Query 630 GVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAV 689 GVM+AV A+E +VAPLL V IAAVN P+S+V+SG ++AV VV DRL G RVR+LAV Sbjct 701 GVMMAVTATEADVAPLLNGDVGIAAVNGPQSLVLSGSESAVKVVADRLAAGGARVRQLAV 760 Query 690 SHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVR 749 SHAFHS LM+PM+ +F+ V+A V R PRI LVSN+TGQLAG YG+ AYWV+HVRKPVR Sbjct 761 SHAFHSPLMEPMMGDFAAVVAGVSAREPRIALVSNLTGQLAGPDYGTVAYWVDHVRKPVR 820 Query 750 FFDGVGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGR 797 F DGV LAESLGA VF+EVGPGA + A SV +A+ RPEV+S+L+ G+ Sbjct 821 FVDGVQLAESLGAGVFLEVGPGAAMTAAVDQCLTTDRAMSVVSMAKGRPEVDSLLSAAGQ 880 Query 798 LFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 LFA G +DWS+ F GL RR+ LPTY F R+RFWL + Sbjct 881 LFATGSDLDWSAAFTGLSARRIPLPTYAFVRRRFWLSSD 919 Score = 93.2 bits (230), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 52/94 (56%), Positives = 68/94 (73%), Gaps = 4/94 (4%) Query 849 GAIARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNR 908 G ARL L+P + Q +LVELVC +AA VLG ++ D++ + AF DLGFDS++ VELRNR Sbjct 1951 GLRARLDGLSPEQRQAELVELVCGNAATVLGHTTA-DVNADDAFGDLGFDSLTAVELRNR 2009 Query 909 LQMAIGLPGLSLPRTLIFDYPTASALAECLGQLL 942 L++A GL+L TLIFD+PT +ALAE LG L Sbjct 2010 LKIAT---GLTLSPTLIFDHPTPAALAEHLGTEL 2040 >gi|49146124|ref|YP_025562.1| Type I modular polyketide synthase [Mycobacterium ulcerans Agy99] gi|42414758|emb|CAE46851.1| Type I modular polyketide synthase [Mycobacterium ulcerans Agy99] Length=16990 Score = 749 bits (1933), Expect = 0.0, Method: Compositional matrix adjust. Identities = 441/895 (50%), Positives = 576/895 (65%), Gaps = 73/895 (8%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 9664 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 9723 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 9724 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 9783 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 9784 AGAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 9841 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 9842 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 9898 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 9899 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 9957 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 9958 DQVDAVEAHGTGTTLGDPIEAGALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 10017 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 10018 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 10077 Query 388 AHVIL-------------EQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAG 434 AH+IL + P QSP ++ AG+ VPWV++A+S +AL+ QA Sbjct 10078 AHLILQQPPTPNPTQTPEDCSPAQSP--CATITDAGTGLSF-VPWVISAKSAEALSAQAS 10134 Query 435 RLLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVV 494 RLL L D + A+D+GWSL++TRS+F+HRAVVVGADR +L GLA LA+G GA VVV Sbjct 10135 RLLTRLDDDPVVDAIDLGWSLIATRSMFEHRAVVVGADRHQLQRGLAELASGNLGADVVV 10194 Query 495 GRARSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGA 554 GRAR+ G+TV VFPGQGSQ LGMG QLY ++ VFA AFD+VV LD LRL +RQVMWG Sbjct 10195 GRARAAGETVMVFPGQGSQRLGMGAQLYEQFPVFAAAFDDVVDALDQYLRLPLRQVMWGD 10254 Query 555 DAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAAR 614 D GLL STEFAQP+LF V+VAL ALL+ WGV+PD V+GHSVGE+AAA VAG LSL DAA+ Sbjct 10255 DEGLLNSTEFAQPSLFAVEVALFALLRFWGVVPDYVIGHSVGELAAAQVAGVLSLQDAAK 10314 Query 615 VVAARGRLMQALPAGGVMVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVV 674 +V+ARGRLMQALPAGG MVAVAAS+ EV PLL EGV IAA+NAP SVVISG+QAAV ++ Sbjct 10315 LVSARGRLMQALPAGGAMVAVAASQHEVEPLLVEGVDIAALNAPGSVVISGDQAAVRLIA 10374 Query 675 DRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGY 734 +RL G R LAVSHAFHS LM+PM+EEF+++ +++ V P+I L+SNVTGQLA A Y Sbjct 10375 NRLADRGYRAHELAVSHAFHSSLMEPMLEEFARLASEIVVEQPQIPLISNVTGQLANADY 10434 Query 735 GSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA-------------SVALL 781 GS YWV+H+R+PVRF D V E++GA F+EVGP +GL A SV+ L Sbjct 10435 GSAGYWVDHIRRPVRFADSVASLEAMGASCFIEVGPASGLGAAIEQSLKSAEPTVSVSAL 10494 Query 782 ARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDN 836 + D+PE +VL RL G+ VDW SVF G + V LPTY F RQRFWL N Sbjct 10495 STDKPESVAVLRAAARLSTSGIPVDWQSVFDGRSTQTVNLPTYAFQRQRFWLDAN 10549 Score = 651 bits (1680), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/900 (45%), Positives = 526/900 (59%), Gaps = 75/900 (8%) Query 6 IAIIGLACRFPTVVSPGDLWDLLRDGREAAGSI--------------------------- 38 +A++G++CR P P LW LLRDG I Sbjct 20 VAVVGMSCRVPGASDPDALWALLRDGISVVDEIPSARWNLDGLVAHRLTDEQRSALRHGA 79 Query 39 --DNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLGAM 96 D+V FDA FF ++P EA +MDP+QRL LELTW LEDA +VPE L G V+ GAM Sbjct 80 FLDDVEGFDAAFFGINPSEAGSMDPQQRLMLELTWAALEDARIVPEHLSGSSSGVFTGAM 139 Query 97 NDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLACE 156 +DDY + H FAGT R++IANRVS+ GLRGPS+ ID+GQSSSLVAVH+A E Sbjct 140 SDDYTTAVTYRAAMTAHTFAGTHRSLIANRVSYTLGLRGPSLVIDTGQSSSLVAVHVAME 199 Query 157 SVRTGEAPLAIAGGVHLNLARETAMLEQEFGAVSPSGHTYAFDERADGYVPGDGGGLVLL 216 S+R E LAIAGG+HLNL+ A+ FGA+SP G Y FD RA+GYV G+GGG+V+L Sbjct 200 SLRREETSLAIAGGIHLNLSLAAALSAAHFGALSPDGRCYTFDARANGYVRGEGGGVVVL 259 Query 217 KPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQVHY 276 K + AL DG+ I+ +IRGS+V N G + LT P V GQ + +A A +D +V Y Sbjct 260 KRLNDALADGNHIYCVIRGSSVNNDG-ATQDLTAPGVDGQRQALLQAYERAEIDPSEVQY 318 Query 277 VEAHGTGTKIGDPIEARALGEIFAARQ--RRPVSVGSVKTNIGHTGGAAGIAGLLKAVLA 334 VE HGTGT++GDP EA +L +F R P+ VGS+KTNIGH GAAGI GL+K LA Sbjct 319 VELHGTGTRLGDPTEAHSLHSVFGTSTVPRSPLLVGSIKTNIGHLEGAAGILGLIKTALA 378 Query 335 IENAVIPPSLNYV--GAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVIL 392 + + +PPSLNY I L+ LGLRV T L+ WP D+P AGVSSF MGGTNAH+IL Sbjct 379 VHHRQLPPSLNYTVPNPKIPLEQLGLRVQTTLSEWPDLDKPLTAGVSSFSMGGTNAHLIL 438 Query 393 EQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLTADDGL 446 +Q PT S A GS+ V V W L+ARS L+ QA RL HL+A L Sbjct 439 QQPPTPDTTQTPNPTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLSAHPDL 498 Query 447 TALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVVGRA-- 497 +DV SL +TRS HRA + + + A A A G ++ R Sbjct 499 DPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLLSRGLL 558 Query 498 --RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWG-- 553 + GKTVFVFPGQGSQ+ GMG LY ++ VFA A DEV A L+ L +++ +VM+ Sbjct 559 TPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDEVAAALNPHLDVALLEVMFSQQ 618 Query 554 --ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVD 611 A A LL+ T +AQPALF + AL L G+ PD ++GHS+GE+ AAY AG LSL D Sbjct 619 DTAMAQLLDQTFYAQPALFALGTALHRLFTHAGIHPDYLLGHSIGELTAAYAAGVLSLQD 678 Query 612 AARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNAPESVVISGEQA 668 AA +V +RGRLMQ+ GG M+A+ ASE EV PLL V IAA+N S+V+SG+ Sbjct 679 AATLVTSRGRLMQSCTPGGTMLALQASEAEVQPLLEGLDHAVSIAAINGATSIVLSGDHD 738 Query 669 AVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQ 728 ++ + + + RR RL VSHAFHS MDP++E+F ++ A + AP + ++SN+TGQ Sbjct 739 SLEQIGEHFITQDRRTTRLQVSHAFHSPHMDPILEQFRQIAAQLTFSAPTLPILSNLTGQ 798 Query 729 LAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS---------- 777 +A SP YW + +R VRF D V G +VF+E+ P L + Sbjct 799 IARHDQLASPDYWTQQLRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTVEQAGG 858 Query 778 ----VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWL 833 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F QR+WL Sbjct 859 GGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQHQRYWL 916 Score = 553 bits (1424), Expect = 8e-155, Method: Compositional matrix adjust. Identities = 360/911 (40%), Positives = 508/911 (56%), Gaps = 91/911 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 1819 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 1878 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 1879 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 1938 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 1939 AWAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 1996 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + +F ++P G AF ADG G+G Sbjct 1997 CQSLRNNESQLALAGGV---TVMSTPAVFTDFSRQRGLAPDGRCKAFAATADGTGWGEGA 2053 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 2054 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 2112 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 2113 DQVDAVEAHGTGTTLGDPIEAGALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 2172 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 2173 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 2232 Query 388 AHVILEQGPTQ-----------SPEIVESVAAAGSNAPVAV-PWVLAARSPQALTNQAGR 435 AH+IL+Q PT S V S +A GS+ V V W L+ARS L+ QA R Sbjct 2233 AHLILQQPPTPDTTQTPNPTTGSDPAVGSDSAVGSDPAVGVLVWPLSARSAPGLSAQAAR 2292 Query 436 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEP 488 L HL+A L +DV SL +TRS HRA + + + A A A Sbjct 2293 LYQHLSAHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANN 2352 Query 489 GAGVVVGRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLR 544 G ++ R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A DEV A L+ L Sbjct 2353 GTHPLLSRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDEVAAALNPHLD 2412 Query 545 LSVRQVMWG----ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 +++ +VM+ A A LL+ T +AQPALF + AL L G+ PD ++GHS+GE+ A Sbjct 2413 VALLEVMFSQQDTAMAQLLDQTFYAQPALFALGTALHRLFTHAGIHPDYLLGHSIGELTA 2472 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNA 657 AY AG LSL DAA +V +RGRLMQ+ GG M+A+ ASE EV PLL V IAA+N Sbjct 2473 AYAAGVLSLQDAATLVTSRGRLMQSCTPGGTMLALQASEAEVQPLLEGLDHAVSIAAING 2532 Query 658 PESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAP 717 S+V+SG+ ++ + + + RR RL VSHAFHS MDP++E+F ++ A + AP Sbjct 2533 ATSIVLSGDHDSLEQIGEHFITQDRRTTRLQVSHAFHSPHMDPILEQFRQIAAQLTFSAP 2592 Query 718 RIGLVSNVTGQLAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA 776 + ++SN+TGQ+A SP YW + +R VRF D V G +VF+E+ P L Sbjct 2593 TLPILSNLTGQIARHDQLASPDYWTQQLRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQ 2652 Query 777 S--------------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELP 822 + V L +DRP+ + A +G+L G++ W+ ++ R + LP Sbjct 2653 AITDTVEQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLP 2710 Query 823 TYGFARQRFWL 833 TY F QR+WL Sbjct 2711 TYAFQHQRYWL 2721 Score = 551 bits (1419), Expect = 3e-154, Method: Compositional matrix adjust. Identities = 360/911 (40%), Positives = 508/911 (56%), Gaps = 91/911 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 15110 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVAGLFDPDPDAVGKTYTRY 15169 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 15170 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 15229 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 15230 AGAQSYGATN--SDDAEGYAMTGGAISVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 15287 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + +F ++P G AF ADG G+G Sbjct 15288 CQSLRNNESQLALAGGV---TVMSTPAVFTDFSRQRGLAPDGRCKAFAATADGTGFGEGA 15344 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 15345 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 15403 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 15404 DQVDAVEAHGTGTTLGDPIEAGALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 15463 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 15464 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 15523 Query 388 AHVILEQGPTQ-----------SPEIVESVAAAGSNAPVAV-PWVLAARSPQALTNQAGR 435 AH+IL+Q PT S V S +A GS+ V V W L+ARS L+ QA R Sbjct 15524 AHLILQQPPTPDTTQTPNPTTGSDPAVGSDSAVGSDPAVGVLVWPLSARSAPGLSAQAAR 15583 Query 436 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEP 488 L HL+A L +DV SL +TRS HRA + + + A A A Sbjct 15584 LYQHLSAHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANN 15643 Query 489 GAGVVVGRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLR 544 G ++ R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A DEV A L+ L Sbjct 15644 GTHPLLSRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDEVAAALNPHLD 15703 Query 545 LSVRQVMWG----ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAA 600 +++ +VM+ A A LL+ T +AQPALF + AL L G+ PD ++GHS+GE+ A Sbjct 15704 VALLEVMFSQQDTAMAQLLDQTFYAQPALFALGTALHRLFTHAGIHPDYLLGHSIGELTA 15763 Query 601 AYVAGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLT---EGVCIAAVNA 657 AY AG LSL DAA +V +RGRLMQ+ GG M+A+ ASE EV PLL V IAA+N Sbjct 15764 AYAAGVLSLQDAATLVTSRGRLMQSCTPGGTMLALQASEAEVQPLLEGLDHAVSIAAING 15823 Query 658 PESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAP 717 S+V+SG+ ++ + + + RR RL VSHAFHS MDP++E+F ++ A + AP Sbjct 15824 ATSIVLSGDHDSLEQIGEHFITQDRRTTRLQVSHAFHSPHMDPILEQFRQIAAQLTFSAP 15883 Query 718 RIGLVSNVTGQLAGAG-YGSPAYWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA 776 + ++SN+TGQ+A SP YW + +R VRF D V G +VF+E+ P L Sbjct 15884 TLPILSNLTGQIARHDQLASPDYWTQQLRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQ 15943 Query 777 S--------------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELP 822 + V L +DRP+ + A +G+L G++ W+ ++ R + LP Sbjct 15944 AITDTVEQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLP 16001 Query 823 TYGFARQRFWL 833 TY F QR+WL Sbjct 16002 TYAFQHQRYWL 16012 Score = 484 bits (1246), Expect = 4e-134, Method: Compositional matrix adjust. Identities = 339/905 (38%), Positives = 477/905 (53%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 11203 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 11262 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V+ G Sbjct 11263 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFAG 11322 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G S ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 11323 AWAQSYGATN--SDDAEGYAMTGGSTSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 11380 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 11381 CQSLRNNESQLALAGGV---TVMSTPAIFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 11437 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 11438 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 11496 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 11497 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 11556 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 11557 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 11616 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 11617 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 11676 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 11677 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 11736 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L SV V Sbjct 11737 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTGWSVLAV 11796 Query 551 MWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSL 609 + +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+VAGAL+L Sbjct 11797 LHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHVAGALTL 11856 Query 610 VDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGE 666 +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S V+SG+ Sbjct 11857 PEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPASAVVSGD 11916 Query 667 QAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVT 726 A+ ++ R + V + HS M+ + +F L ++ R I + S V Sbjct 11917 TTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIAMYSTVD 11976 Query 727 GQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 G+ Y + YW ++R VRF D V G +VF+E+ P L + Sbjct 11977 GEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 12036 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 12037 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 12094 Query 829 QRFWL 833 QR+WL Sbjct 12095 QRYWL 12099 Score = 484 bits (1245), Expect = 5e-134, Method: Compositional matrix adjust. Identities = 339/905 (38%), Positives = 477/905 (53%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 12996 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 13055 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V+ G Sbjct 13056 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFAG 13115 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G S ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 13116 AWAQSYGATN--SDDAEGYAMTGGSTSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 13173 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 13174 CQSLRNNESQLALAGGV---TVMSTPAVFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 13230 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 13231 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 13289 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 13290 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 13349 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 13350 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 13409 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 13410 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 13469 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 13470 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 13529 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L SV V Sbjct 13530 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTGWSVLAV 13589 Query 551 MWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSL 609 + +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+VAGAL+L Sbjct 13590 LHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHVAGALTL 13649 Query 610 VDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGE 666 +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S V+SG+ Sbjct 13650 PEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPASAVVSGD 13709 Query 667 QAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVT 726 A+ ++ R + V + HS M+ + +F L ++ R I + S V Sbjct 13710 TTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIAMYSTVD 13769 Query 727 GQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 G+ Y + YW ++R VRF D V G +VF+E+ P L + Sbjct 13770 GEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 13829 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 13830 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 13887 Query 829 QRFWL 833 QR+WL Sbjct 13888 QRYWL 13892 Score = 483 bits (1242), Expect = 9e-134, Method: Compositional matrix adjust. Identities = 340/911 (38%), Positives = 481/911 (53%), Gaps = 91/911 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 3624 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 3683 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 3684 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 3743 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 3744 AGAQSYGATN--SDDAEGYAMTGGATSVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 3801 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 3802 CQSLRNNESQLALAGGV---TVMSTPAIFTEFSRQRGLAPDGRCKAFAATADGTGWGEGA 3858 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 3859 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 3917 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 3918 DQVDAVEAHGTGTTLGDPIEAGALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 3977 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 3978 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 4037 Query 388 AHVILEQGPTQ-----------SPEIVESVAAAGSNAPVAV-PWVLAARSPQALTNQAGR 435 AH+IL+Q PT S V S +A GS+ V V W L+ARS L+ QA R Sbjct 4038 AHLILQQPPTPDTTQTPNPTTGSDPAVGSDSAVGSDPAVGVLVWPLSARSAPGLSAQAAR 4097 Query 436 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEP 488 L HL+A L +DV SL +TRS HRA + + + A A A Sbjct 4098 LYQHLSAHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANN 4157 Query 489 GAGVVVGRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLR 544 G ++ R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L Sbjct 4158 GTHPLLSRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTG 4217 Query 545 LSVRQVMWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYV 603 SV V+ +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+V Sbjct 4218 WSVLAVLHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHV 4277 Query 604 AGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPES 660 AGAL+L +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S Sbjct 4278 AGALTLPEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPAS 4337 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 V+SG+ A+ ++ R + V + HS M+ + +F L ++ R I Sbjct 4338 AVVSGDTTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIA 4397 Query 721 LVSNVTGQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA 776 + S V G+ Y + YW ++R VRF D V G +VF+E+ P L Sbjct 4398 MYSTVDGEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQ 4457 Query 777 S--------------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELP 822 + V L +DRP+ + A +G+L G++ W+ ++ R + LP Sbjct 4458 AITDTVEQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLP 4515 Query 823 TYGFARQRFWL 833 TY F QR+WL Sbjct 4516 TYAFQHQRYWL 4526 Score = 482 bits (1241), Expect = 1e-133, Method: Compositional matrix adjust. Identities = 340/911 (38%), Positives = 481/911 (53%), Gaps = 91/911 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 5745 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 5804 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 5805 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 5864 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 5865 AGAQSYGATN--SDGAEGYAMTGGAISVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 5922 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + EF ++P G AF ADG G+G Sbjct 5923 CQSLRNNESQLALAGGV---TVMSTPAIFTEFSRQRGLAPDGRCKAFAATADGTGFGEGA 5979 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 5980 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 6038 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 6039 DQVDAVEAHGTGTTLGDPIEASALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 6098 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 6099 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 6158 Query 388 AHVILEQGPTQ-----------SPEIVESVAAAGSNAPVAV-PWVLAARSPQALTNQAGR 435 AH+IL+Q PT S V S +A GS+ V V W L+ARS L+ QA R Sbjct 6159 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDSAVGSDPAVGVLVWPLSARSAPGLSAQAAR 6218 Query 436 LLAHLTADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEP 488 L HL+A L +DV SL +TRS HRA + + + A A A Sbjct 6219 LYQHLSAHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANN 6278 Query 489 GAGVVVGRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLR 544 G ++ R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L Sbjct 6279 GTHPLLSRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTG 6338 Query 545 LSVRQVMWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYV 603 SV V+ +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+V Sbjct 6339 WSVLAVLHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHV 6398 Query 604 AGALSLVDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPES 660 AGAL+L +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S Sbjct 6399 AGALTLPEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPAS 6458 Query 661 VVISGEQAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIG 720 V+SG+ A+ ++ R + V + HS M+ + +F L ++ R I Sbjct 6459 AVVSGDTTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIA 6518 Query 721 LVSNVTGQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEA 776 + S V G+ Y + YW ++R VRF D V G +VF+E+ P L Sbjct 6519 MYSTVDGEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQ 6578 Query 777 S--------------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELP 822 + V L +DRP+ + A +G+L G++ W+ ++ R + LP Sbjct 6579 AITDTVEQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLP 6636 Query 823 TYGFARQRFWL 833 TY F QR+WL Sbjct 6637 TYAFQHQRYWL 6647 Score = 480 bits (1236), Expect = 6e-133, Method: Compositional matrix adjust. Identities = 337/905 (38%), Positives = 478/905 (53%), Gaps = 85/905 (9%) Query 6 IAIIGLACRFPTVVSPGD-LWDLLRDGREAAGS--------------------------- 37 +A++G+ACRFP V+ D LWDL+ GR+ G+ Sbjct 7549 VAVVGMACRFPGGVASADQLWDLVIAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRY 7608 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +D+ A FDA FF +SPREA AMDP+QRL LE+ WE LE A + TL G V++G Sbjct 7609 GAFLDDAAGFDAGFFGISPREARAMDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVG 7668 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 A Y +D + +A G + ++++ R+++ GL GP++T+D+ SSSLVA+HLA Sbjct 7669 AWAQSYGATN--SDDAEGYAMTGGAISVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLA 7726 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLEQEFG---AVSPSGHTYAFDERADGYVPGDGG 211 C+S+R E+ LA+AGGV T + +F ++P G AF ADG G+G Sbjct 7727 CQSLRNNESQLALAGGV---TVMSTPAVFTDFSRQRGLAPDGRCKAFAATADGTGFGEGA 7783 Query 212 GLVLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDC 271 +++L+ + A + + AI+ GSA+ G ++ GLT P Q VI +A++ AG+ Sbjct 7784 AVLVLERLSEARRNNHPVLAIVAGSAINQDG-ASNGLTAPHGPSQQRVINQALANAGLTH 7842 Query 272 HQVHYVEAHGTGTKIGDPIEARALGEIFAARQR--RPVSVGSVKTNIGHTGGAAGIAGLL 329 QV VEAHGTGT +GDPIEA AL + +P+ +GS+K+NIGHT AAG AG++ Sbjct 7843 DQVDAVEAHGTGTTLGDPIEAGALHATYGHHHTPDQPLWLGSIKSNIGHTQAAAGAAGVV 7902 Query 330 KAVLAIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTN 387 K + AI +A +P +L + ID S +R+ T WP D PR A VSSFG+ GTN Sbjct 7903 KMIQAITHATLPATLHVDQPSPHIDWSSGTVRLLTEPIQWPNTDHPRTAAVSSFGISGTN 7962 Query 388 AHVILEQGPTQSPEIVE-----SVAAAGSNAPVAV-PWVLAARSPQALTNQAGRLLAHLT 441 AH+IL+Q PT S A GS+ V V W L+ARS L+ QA RL HL+ Sbjct 7963 AHLILQQPPTPDTTQTPNTTTGSDPAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLS 8022 Query 442 ADDGLTALDVGWSLVSTRSVFDHRAVVVGA-------DRGRLMAGLAGLAAGEPGAGVVV 494 A L +DV SL +TRS HRA + + + A A A G ++ Sbjct 8023 AHPDLDPIDVAHSLATTRSHHPHRATITTSIEHHSENNHDTTDALAALHALANNGTHPLL 8082 Query 495 GRA----RSVGKTVFVFPGQGSQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQV 550 R + GKTVFVFPGQGSQ+ GMG LY ++ VFA A D A L SV V Sbjct 8083 SRGLLTPQGPGKTVFVFPGQGSQYPGMGADLYRQFPVFAHALDACDAALQPFTGWSVLAV 8142 Query 551 MWG-ADAGLLESTEFAQPALFVVQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSL 609 + +A LE + QP LF V V+LAAL + G+ PD V+GHS GEIAAA+VAGAL+L Sbjct 8143 LHDEPEAPSLERVDVVQPVLFSVMVSLAALWRWAGITPDAVIGHSQGEIAAAHVAGALTL 8202 Query 610 VDAARVVAARGRLMQALPAGGVMVAVAASEDEVAPLLTE---GVCIAAVNAPESVVISGE 666 +AA VVA R R++ L G M +V + E+ + LL + +AAVN P S V+SG+ Sbjct 8203 PEAAAVVALRSRVLTDLAGAGAMASVLSPEEPLTQLLARWDGKITVAAVNGPASAVVSGD 8262 Query 667 QAAVGVVVDRLVGLGRRVRRLAVSHAFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVT 726 A+ ++ R + V + HS M+ + +F L ++ R I + S V Sbjct 8263 TTAITELLITCEHENIDARAIPVDYPSHSPYMEHIRHQFLDELPELTPRPSTIAMYSTVD 8322 Query 727 GQLAGAGYGSPA----YWVEHVRKPVRFFDGVGLAESLGARVFVEVGPGAGLEAS----- 777 G+ Y + YW ++R VRF D V G +VF+E+ P L + Sbjct 8323 GEPHDTAYDTTTMTADYWYRNIRNTVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTV 8382 Query 778 ---------VALLARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFAR 828 V L +DRP+ + A +G+L G++ W+ ++ R + LPTY F Sbjct 8383 EQAGGGGAAVPALRKDRPDAVAFAAALGQLHCHGISPSWNVLYC--QARPLTLPTYAFQH 8440 Query 829 QRFWL 833 QR+WL Sbjct 8441 QRYWL 8445 Score = 73.6 bits (179), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/170 (33%), Positives = 86/170 (51%), Gaps = 30/170 (17%) Query 782 ARDRPEVESVLAGVGRLFAEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGE-LS 840 A DRP+ +A +V+W + PT+ AR R +L + E ++ Sbjct 11037 AIDRPQATLTVA----------SVNWDRFY----------PTFALARPRPFLHEITEVMA 11076 Query 841 VDQTGKDAGA------IARLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQD 894 ++ + + A ++L L E + +LV AA VLG S+ +D +F+D Sbjct 11077 YRESMRSSSASTATLLTSKLAGLTATEQRAVTRKLVLDQAASVLGYASTESLDTHESFKD 11136 Query 895 LGFDSMSGVELRNRLQMAIGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 LGFDS++ +ELR+ LQ A GL+L TLIFD+PT A+AE L + + G Sbjct 11137 LGFDSLTALELRDHLQTAT---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 11183 Score = 64.3 bits (155), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 48/109 (45%), Positives = 61/109 (56%), Gaps = 4/109 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 16809 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 16868 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGGQHESSDDESIWQLLKNI 961 GL LP TLIFD+PT +AL + L L Q ES + E LKN+ Sbjct 16869 T---GLDLPPTLIFDHPTPTALTQHLHTRL-TQIESPNSEDSMLNLKNL 16913 Score = 60.8 bits (146), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/92 (46%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 12888 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 12947 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL LP TLIFD+PT A+AE L + + G Sbjct 12948 T---GLDLPPTLIFDHPTPHAVAEHLLEQIPG 12976 Score = 59.7 bits (143), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 41/90 (46%), Positives = 52/90 (58%), Gaps = 3/90 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 7442 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 7501 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLL 942 GL LP TLIFD+PT +AL + L L Sbjct 7502 T---GLDLPPTLIFDHPTPTALTQHLHTRL 7528 Score = 59.7 bits (143), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 41/90 (46%), Positives = 52/90 (58%), Gaps = 3/90 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 15003 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 15062 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLL 942 GL LP TLIFD+PT +AL + L L Sbjct 15063 T---GLDLPPTLIFDHPTPTALTQHLHTRL 15089 Score = 58.5 bits (140), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/92 (45%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 1711 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 1770 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL+L TLIFD+PT A+AE L + + G Sbjct 1771 T---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 1799 Score = 58.5 bits (140), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/92 (45%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 3516 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 3575 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL+L TLIFD+PT A+AE L + + G Sbjct 3576 T---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 3604 Score = 58.5 bits (140), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/92 (45%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 5637 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 5696 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL+L TLIFD+PT A+AE L + + G Sbjct 5697 T---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 5725 Score = 58.5 bits (140), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/92 (45%), Positives = 54/92 (59%), Gaps = 3/92 (3%) Query 853 RLQSLAPPELQRQLVELVCFHAAIVLGRKSSHDIDPECAFQDLGFDSMSGVELRNRLQMA 912 RL L+P + Q+ L LV A VLG + I P AF+DLG DS++ +ELRN L Sbjct 9556 RLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTALELRNTLTHN 9615 Query 913 IGLPGLSLPRTLIFDYPTASALAECLGQLLGG 944 GL+L TLIFD+PT A+AE L + + G Sbjct 9616 T---GLNLSSTLIFDHPTPHAVAEHLLEQIPG 9644 >gi|289753752|ref|ZP_06513130.1| polyketide synthase pks8 [Mycobacterium tuberculosis EAS054] gi|289694339|gb|EFD61768.1| polyketide synthase pks8 [Mycobacterium tuberculosis EAS054] Length=1358 Score = 748 bits (1932), Expect = 0.0, Method: Compositional matrix adjust. Identities = 442/886 (50%), Positives = 571/886 (65%), Gaps = 54/886 (6%) Query 6 IAIIGLACRFPT-VVSPGDLWDLLRDGREAAGS--------------------------- 37 +A++G+ CR+P V SP LW+L+ GR+A Sbjct 36 VAVVGMGCRYPGGVDSPETLWELVAQGRDAVSDFPADRGWDVDGLFDPDPDACGKMYTRR 95 Query 38 ---IDNVADFDADFFNLSPREASAMDPRQRLALELTWELLEDAFVVPETLRGQPIAVYLG 94 +++ DFDA FF + P EA AMDP+QRL LE++WE LE + P LRG V+ G Sbjct 96 GTFLEHAGDFDAGFFGIGPSEALAMDPQQRLLLEVSWEALERTGIDPTKLRGSATGVFAG 155 Query 95 AMNDDYAVLTLAADRVDHHAFAGTSRAIIANRVSFAFGLRGPSVTIDSGQSSSLVAVHLA 154 ++ Y + ++ + G++ ++ + RV++ GL GP+V++D+ SSSLVA+HLA Sbjct 156 VIHAGYG--GQLSGELEGYGLTGSTLSVASGRVAYVLGLEGPAVSVDTACSSSLVALHLA 213 Query 155 CESVRTGEAPLAIAGGVHLNLARETAMLE-QEFGAVSPSGHTYAFDERADGYVPGDGGGL 213 +S+R+GE LA+AGGV + +A A +E A++ G + ADG +G G+ Sbjct 214 VQSLRSGECDLALAGGVTV-MATPAAFVEFSRQRALARDGRCKVYAGAADGTAWSEGAGV 272 Query 214 VLLKPVQAALDDGDRIHAIIRGSAVGNAGHSATGLTVPSVAGQVDVIRRAMSGAGVDCHQ 273 ++++ + A G + A++RGSAV G S GLT P+ + Q VIR A++ A + + Sbjct 273 LVVERLVDARRLGHPVLALVRGSAVNQDGAS-NGLTAPNGSSQQRVIRAALASARLRRVE 331 Query 274 VHYVEAHGTGTKIGDPIEARALGEIFAARQRRPVSVGSVKTNIGHTGGAAGIAGLLKAVL 333 V VE HGTGT +GDPIEA+AL + + P+ +GS+K+NIGHT AAG+AG++K V Sbjct 332 VDVVEGHGTGTMLGDPIEAQALLATYGQDRVEPLWLGSIKSNIGHTSAAAGVAGVIKMVQ 391 Query 334 AIENAVIPPSL--NYVGAAIDLDSLGLRVDTALTPWPVADEPRRAGVSSFGMGGTNAHVI 391 A+ + V+P +L + +D + + T W V PRRAGVSSFG+ GTNAHVI Sbjct 392 AMRHGVMPKTLHVDVPTPHVDWSVGAVSLLTQPRAWSVHGRPRRAGVSSFGISGTNAHVI 451 Query 392 LEQGPTQSPEIVESVAAAGSNAPVAVPWVLAARSPQALTNQAGRLLAHLTADDGLTALDV 451 LEQ P A A AVPWVL+ARS QAL QA RLLA + A+ L +DV Sbjct 452 LEQAPVVE---SVVPEVASPTAASAVPWVLSARSEQALAGQAQRLLAFVAANPDLDPIDV 508 Query 452 GWSLVSTRSVFDHRAVVVGADRGRLMAGLAGLAAGEPGAGVVVGRARSVGKTVFVFPGQG 511 GWSLV TR++F+HRAVVVGADRG L+AGLA LAAGE GAGV VGRARSVGKTVFVFPGQG Sbjct 509 GWSLVKTRAMFEHRAVVVGADRGALLAGLAALAAGESGAGVAVGRARSVGKTVFVFPGQG 568 Query 512 SQWLGMGRQLYGRYSVFARAFDEVVAVLDGQLRLSVRQVMWGADAGLLESTEFAQPALFV 571 +QW+GMG QLY +FA AFD V LD LRL +R V+W D LL STEFAQPALF Sbjct 569 AQWVGMGAQLYAELPLFALAFDAVAEELDRHLRLPLRNVLWEGDEALLTSTEFAQPALFA 628 Query 572 VQVALAALLQDWGVLPDLVMGHSVGEIAAAYVAGALSLVDAARVVAARGRLMQALPAGGV 631 ++VALA LLQ WG+ PD ++GHSVGEIAAA++AG LSL DAA +VAARGRLM LPAGGV Sbjct 629 IEVALATLLQHWGISPDFLIGHSVGEIAAAHLAGVLSLTDAAGLVAARGRLMAELPAGGV 688 Query 632 MVAVAASEDEVAPLLTEGVCIAAVNAPESVVISGEQAAVGVVVDRLVGLGRRVRRLAVSH 691 MV VAASE+EV P+L +G +AAVNAP SVV+SG +AAV + D GRRV RLAVSH Sbjct 689 MVVVAASEEEVLPVLVDGANLAAVNAPHSVVVSGCEAAVSDIADHFARRGRRVHRLAVSH 748 Query 692 AFHSVLMDPMVEEFSKVLADVCVRAPRIGLVSNVTGQLAGAGYGSPAYWVEHVRKPVRFF 751 AFHS+LM+PM+ EF+++ A + V PRI LVSNVTGQ+AGAGYG YWVEH R+PVRF Sbjct 749 AFHSLLMEPMLAEFTRIAAGISVSKPRIPLVSNVTGQMAGAGYGDGQYWVEHARRPVRFA 808 Query 752 DGVGLAESLGARVFVEVGPGAGLEA------------SVALLARDRPEVESVLAGVGRLF 799 +GV L ++GA FVEVGPG GL A SVA++ R+ PEV SVL V LF Sbjct 809 EGVQLLNAVGATRFVEVGPGGGLTALVEQSLPLGEALSVAMMRREHPEVSSVLGAVATLF 868 Query 800 AEGVAVDWSSVFAGLGGRRVELPTYGFARQRFWLGDNGELSVDQTG 845 G +DW +VF G GRR+ELPTY F RQR+WL S D +G Sbjct 869 TAGAQMDWPAVF-GSPGRRIELPTYAFQRQRYWLPPTSAGSADISG 913 Lambda K H 0.319 0.136 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 2545019273496 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40