BLASTP 2.2.25+
Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
15,229,318 sequences; 5,219,829,388 total letters
Query= Rv1703c
Length=196
Score E
Sequences producing significant alignments: (Bits) Value
gi|15841161|ref|NP_336198.1| catechol-O-methyltransferase [Mycob... 400 4e-110
gi|31792889|ref|NP_855382.1| catechol-o-methyltransferase [Mycob... 399 1e-109
gi|253799259|ref|YP_003032260.1| catechol-O-methyltransferase [M... 399 2e-109
gi|289554525|ref|ZP_06443735.1| catechol-O-methyltransferase [My... 397 4e-109
gi|121637610|ref|YP_977833.1| putative catechol-o-methyltransfer... 397 5e-109
gi|340626709|ref|YP_004745161.1| putative catechol-o-methyltrans... 396 8e-109
gi|289443160|ref|ZP_06432904.1| catechol-O-methyltransferase [My... 374 4e-102
gi|342860720|ref|ZP_08717370.1| catechol-O-methyltransferase [My... 342 2e-92
gi|254818893|ref|ZP_05223894.1| catechol-O-methyltransferase [My... 331 3e-89
gi|333990498|ref|YP_004523112.1| O-methyltransferase [Mycobacter... 328 2e-88
gi|183982522|ref|YP_001850813.1| O-methyltransferase [Mycobacter... 318 3e-85
gi|296164602|ref|ZP_06847169.1| catechol-O-methyltransferase [My... 317 4e-85
gi|118617319|ref|YP_905651.1| O-methyltransferase [Mycobacterium... 317 5e-85
gi|41407507|ref|NP_960343.1| hypothetical protein MAP1409c [Myco... 311 3e-83
gi|120404255|ref|YP_954084.1| catechol O-methyltransferase [Myco... 311 4e-83
gi|336457861|gb|EGO36855.1| putative O-methyltransferase [Mycoba... 310 7e-83
gi|118464980|ref|YP_882253.1| catechol-O-methyltransferase [Myco... 305 2e-81
gi|254775521|ref|ZP_05217037.1| hypothetical protein MaviaA2_127... 304 3e-81
gi|240170157|ref|ZP_04748816.1| catechol-O-methyltransferase [My... 300 8e-80
gi|145224083|ref|YP_001134761.1| catechol O-methyltransferase [M... 288 4e-76
gi|169628411|ref|YP_001702060.1| catechol-o-methyltransferase [M... 275 3e-72
gi|317506730|ref|ZP_07964513.1| catechol O-methyltransferase [Se... 227 8e-58
gi|209735740|gb|ACI68739.1| Catechol O-methyltransferase [Salmo ... 136 2e-30
gi|225708338|gb|ACO10015.1| Catechol O-methyltransferase [Osmeru... 135 4e-30
gi|317418959|emb|CBN80997.1| Catechol O-methyltransferase [Dicen... 134 7e-30
gi|302795013|ref|XP_002979270.1| hypothetical protein SELMODRAFT... 134 8e-30
gi|302813782|ref|XP_002988576.1| hypothetical protein SELMODRAFT... 133 1e-29
gi|332634793|ref|NP_001025328.2| catechol-O-methyltransferase a ... 132 2e-29
gi|169158753|emb|CAQ14945.1| novel protein similar to vertebrate... 132 2e-29
gi|139949106|ref|NP_001077312.1| catechol O-methyltransferase [D... 132 3e-29
gi|33468632|emb|CAE30427.1| novel protein similar to human and r... 132 3e-29
gi|148227708|ref|NP_001079715.1| similar to catecholamine-O-meth... 132 3e-29
gi|224071830|ref|XP_002198695.1| PREDICTED: catechol-O-methyltra... 130 1e-28
gi|62858577|ref|NP_001016357.1| catechol-O-methyltransferase [Xe... 130 1e-28
gi|148236243|ref|NP_001090344.1| catechol-O-methyltransferase [X... 129 2e-28
gi|209736918|gb|ACI69328.1| Catechol O-methyltransferase [Salmo ... 129 2e-28
gi|167621424|ref|NP_001108007.1| catechol O-methyltransferase is... 129 2e-28
gi|126352448|ref|NP_001075303.1| catechol O-methyltransferase is... 129 2e-28
gi|296191360|ref|XP_002743590.1| PREDICTED: catechol O-methyltra... 129 3e-28
gi|326929526|ref|XP_003210914.1| PREDICTED: catechol O-methyltra... 128 5e-28
gi|168028905|ref|XP_001766967.1| predicted protein [Physcomitrel... 127 1e-27
gi|47209089|emb|CAF90723.1| unnamed protein product [Tetraodon n... 126 1e-27
gi|166157808|ref|NP_001107540.1| hypothetical protein LOC1001354... 126 2e-27
gi|161484634|ref|NP_031770.2| catechol O-methyltransferase [Mus ... 126 2e-27
gi|5921831|sp|O88587.1|COMT_MOUSE RecName: Full=Catechol O-methy... 125 2e-27
gi|109093290|ref|XP_001105683.1| PREDICTED: catechol O-methyltra... 125 5e-27
gi|126344631|ref|XP_001380438.1| PREDICTED: catechol O-methyltra... 124 7e-27
gi|189339616|pdb|3BWM|A Chain A, Crystal Structure Of Human Cate... 124 8e-27
gi|6466450|ref|NP_009294.1| catechol O-methyltransferase isoform... 124 8e-27
gi|306991591|pdb|3A7E|A Chain A, Crystal Structure Of Human Comt... 124 8e-27
>gi|15841161|ref|NP_336198.1| catechol-O-methyltransferase [Mycobacterium tuberculosis CDC1551]
gi|148822909|ref|YP_001287663.1| catechol-O-methyltransferase [Mycobacterium tuberculosis F11]
gi|167969178|ref|ZP_02551455.1| hypothetical catechol-O-methyltransferase [Mycobacterium tuberculosis
H37Ra]
43 more sequence titles
Length=233
Score = 400 bits (1029), Expect = 4e-110, Method: Compositional matrix adjust.
Identities = 196/196 (100%), Positives = 196/196 (100%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR
Sbjct 38 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 97
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD
Sbjct 98 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 157
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE
Sbjct 158 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 217
Query 181 YQTLVPDLVLESEYLG 196
YQTLVPDLVLESEYLG
Sbjct 218 YQTLVPDLVLESEYLG 233
>gi|31792889|ref|NP_855382.1| catechol-o-methyltransferase [Mycobacterium bovis AF2122/97]
gi|148661500|ref|YP_001283023.1| catechol-O-methyltransferase [Mycobacterium tuberculosis H37Ra]
gi|289569752|ref|ZP_06449979.1| catechol-O-methyltransferase [Mycobacterium tuberculosis T17]
17 more sequence titles
Length=196
Score = 399 bits (1024), Expect = 1e-109, Method: Compositional matrix adjust.
Identities = 195/196 (99%), Positives = 196/196 (100%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR
Sbjct 1 MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD
Sbjct 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE
Sbjct 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
Query 181 YQTLVPDLVLESEYLG 196
YQTLVPDLVLESEYLG
Sbjct 181 YQTLVPDLVLESEYLG 196
>gi|253799259|ref|YP_003032260.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
1435]
gi|297634255|ref|ZP_06952035.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
4207]
gi|297731242|ref|ZP_06960360.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
R506]
gi|313658574|ref|ZP_07815454.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
V2475]
gi|253320762|gb|ACT25365.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
1435]
gi|328459011|gb|AEB04434.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
4207]
Length=233
Score = 399 bits (1024), Expect = 2e-109, Method: Compositional matrix adjust.
Identities = 195/196 (99%), Positives = 195/196 (99%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR
Sbjct 38 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 97
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD
Sbjct 98 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 157
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAP YRAYMRRQQGMSWNTIEHKTHLE
Sbjct 158 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPTYRAYMRRQQGMSWNTIEHKTHLE 217
Query 181 YQTLVPDLVLESEYLG 196
YQTLVPDLVLESEYLG
Sbjct 218 YQTLVPDLVLESEYLG 233
>gi|289554525|ref|ZP_06443735.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
605]
gi|289439157|gb|EFD21650.1| catechol-O-methyltransferase [Mycobacterium tuberculosis KZN
605]
Length=240
Score = 397 bits (1020), Expect = 4e-109, Method: Compositional matrix adjust.
Identities = 195/196 (99%), Positives = 195/196 (99%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR
Sbjct 45 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 104
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD
Sbjct 105 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 164
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAP YRAYMRRQQGMSWNTIEHKTHLE
Sbjct 165 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPTYRAYMRRQQGMSWNTIEHKTHLE 224
Query 181 YQTLVPDLVLESEYLG 196
YQTLVPDLVLESEYLG
Sbjct 225 YQTLVPDLVLESEYLG 240
>gi|121637610|ref|YP_977833.1| putative catechol-o-methyltransferase [Mycobacterium bovis BCG
str. Pasteur 1173P2]
gi|224990085|ref|YP_002644772.1| putative catechol-O-methyltransferase [Mycobacterium bovis BCG
str. Tokyo 172]
gi|121493257|emb|CAL71728.1| Probable catechol-o-methyltransferase [Mycobacterium bovis BCG
str. Pasteur 1173P2]
gi|224773198|dbj|BAH26004.1| putative catechol-O-methyltransferase [Mycobacterium bovis BCG
str. Tokyo 172]
gi|341601628|emb|CCC64301.1| probable catechol-o-methyltransferase [Mycobacterium bovis BCG
str. Moreau RDJ]
Length=196
Score = 397 bits (1020), Expect = 5e-109, Method: Compositional matrix adjust.
Identities = 194/196 (99%), Positives = 195/196 (99%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGY ALRIARAAPEAR
Sbjct 1 MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYSALRIARAAPEAR 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD
Sbjct 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE
Sbjct 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
Query 181 YQTLVPDLVLESEYLG 196
YQTLVPDLVLESEYLG
Sbjct 181 YQTLVPDLVLESEYLG 196
>gi|340626709|ref|YP_004745161.1| putative catechol-o-methyltransferase [Mycobacterium canettii
CIPT 140010059]
gi|340004899|emb|CCC44045.1| putative catechol-o-methyltransferase [Mycobacterium canettii
CIPT 140010059]
Length=196
Score = 396 bits (1018), Expect = 8e-109, Method: Compositional matrix adjust.
Identities = 194/196 (99%), Positives = 195/196 (99%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR
Sbjct 1 MLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
VYSVELAEANASNARRIWAHAGVDDRVVCVVGTI DGGRTLDALTEHGFATGTLDFVFLD
Sbjct 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIDDGGRTLDALTEHGFATGTLDFVFLD 120
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE
Sbjct 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
Query 181 YQTLVPDLVLESEYLG 196
YQTLVPDLVLESEYLG
Sbjct 181 YQTLVPDLVLESEYLG 196
>gi|289443160|ref|ZP_06432904.1| catechol-O-methyltransferase [Mycobacterium tuberculosis T46]
gi|289416079|gb|EFD13319.1| catechol-O-methyltransferase [Mycobacterium tuberculosis T46]
Length=183
Score = 374 bits (960), Expect = 4e-102, Method: Compositional matrix adjust.
Identities = 183/183 (100%), Positives = 183/183 (100%), Gaps = 0/183 (0%)
Query 14 MLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARVYSVELAEANASN 73
MLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARVYSVELAEANASN
Sbjct 1 MLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARVYSVELAEANASN 60
Query 74 ARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLDHDKKAYLPDLQSI 133
ARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLDHDKKAYLPDLQSI
Sbjct 61 ARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLDHDKKAYLPDLQSI 120
Query 134 LDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLEYQTLVPDLVLESE 193
LDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLEYQTLVPDLVLESE
Sbjct 121 LDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLEYQTLVPDLVLESE 180
Query 194 YLG 196
YLG
Sbjct 181 YLG 183
>gi|342860720|ref|ZP_08717370.1| catechol-O-methyltransferase [Mycobacterium colombiense CECT
3035]
gi|342131744|gb|EGT85001.1| catechol-O-methyltransferase [Mycobacterium colombiense CECT
3035]
Length=198
Score = 342 bits (877), Expect = 2e-92, Method: Compositional matrix adjust.
Identities = 166/197 (85%), Positives = 184/197 (94%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATIDKFAYEKS+LINVGDEKG LLDAAVRRADPALALELGTY GYGALRIARAAP+A+
Sbjct 1 MLATIDKFAYEKSLLINVGDEKGLLLDAAVRRADPALALELGTYCGYGALRIARAAPKAK 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
V+SVELA+ANA+NAR+IWAHAGV DRV CVVGTIGDGGRTLDAL TEHGFA GTLDFVFL
Sbjct 61 VFSVELADANAANARQIWAHAGVADRVTCVVGTIGDGGRTLDALATEHGFAEGTLDFVFL 120
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DL+SI++RGWLHPGSIVVADNVRVPGAPKYR YM RQQG ++T+EHKTH+
Sbjct 121 DHDKDAYLDDLKSIMERGWLHPGSIVVADNVRVPGAPKYREYMHRQQGKLFSTVEHKTHV 180
Query 180 EYQTLVPDLVLESEYLG 196
EYQT++ DLVLES+YLG
Sbjct 181 EYQTMLSDLVLESDYLG 197
>gi|254818893|ref|ZP_05223894.1| catechol-O-methyltransferase [Mycobacterium intracellulare ATCC
13950]
Length=196
Score = 331 bits (849), Expect = 3e-89, Method: Compositional matrix adjust.
Identities = 170/196 (87%), Positives = 179/196 (92%), Gaps = 0/196 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+L TIDKFAYEKSMLINVGDEKG LLDAAVRRADPALALELGTY GYGALRIARAAP+A+
Sbjct 1 MLTTIDKFAYEKSMLINVGDEKGLLLDAAVRRADPALALELGTYCGYGALRIARAAPKAK 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFLD 120
V+SVELAEANA+NAR+IWAHAGV DRV CVVGTIGDGGRTLD L EHGFA G LDFVFLD
Sbjct 61 VFSVELAEANAANARQIWAHAGVADRVTCVVGTIGDGGRTLDVLAEHGFAAGALDFVFLD 120
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDK AYL DL+SILDRGWLHPGSIVVADNVRVPGAPKYR YM R QG WNT+EHKTHLE
Sbjct 121 HDKDAYLDDLKSILDRGWLHPGSIVVADNVRVPGAPKYRGYMHRHQGTRWNTVEHKTHLE 180
Query 181 YQTLVPDLVLESEYLG 196
YQ+LV DLVLESEYLG
Sbjct 181 YQSLVSDLVLESEYLG 196
>gi|333990498|ref|YP_004523112.1| O-methyltransferase [Mycobacterium sp. JDM601]
gi|333486466|gb|AEF35858.1| O-methyltransferase [Mycobacterium sp. JDM601]
Length=273
Score = 328 bits (842), Expect = 2e-88, Method: Compositional matrix adjust.
Identities = 157/197 (80%), Positives = 174/197 (89%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLA ID+FAYEKS+LIN+GDEKG LLDAAV+R PALALELGTY GY ALRIAR+AP AR
Sbjct 77 VLARIDEFAYEKSLLINIGDEKGALLDAAVQRVQPALALELGTYCGYSALRIARSAPAAR 136
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALT-EHGFATGTLDFVFL 119
+YS+ELAEANA NAR+IWAHAGV DR+ CVVGTIGDGGRTLD LT HGFA GTLDF+FL
Sbjct 137 IYSIELAEANADNARQIWAHAGVADRITCVVGTIGDGGRTLDVLTARHGFAAGTLDFLFL 196
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DLQSILDRGWLHPGS+VVADNV+VPGAP+YR YMR QQG W+T+EHKTH+
Sbjct 197 DHDKDAYLSDLQSILDRGWLHPGSVVVADNVKVPGAPRYREYMRAQQGTHWDTVEHKTHV 256
Query 180 EYQTLVPDLVLESEYLG 196
EYQ L+ DLVLES YLG
Sbjct 257 EYQRLLSDLVLESTYLG 273
>gi|183982522|ref|YP_001850813.1| O-methyltransferase [Mycobacterium marinum M]
gi|183175848|gb|ACC40958.1| O-methyltransferase [Mycobacterium marinum M]
Length=250
Score = 318 bits (815), Expect = 3e-85, Method: Compositional matrix adjust.
Identities = 168/197 (86%), Positives = 179/197 (91%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATIDKFAYEKS+L+NVGDEKG LLDAAVRRADPALALELGTY GYGALRIARAAP+A+
Sbjct 54 VLATIDKFAYEKSILVNVGDEKGLLLDAAVRRADPALALELGTYCGYGALRIARAAPQAK 113
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
VYSVELAEANA+NAR+IWAHAGV DRV CVVGTIGDGGRTLDAL TEHGFA G LDFVF+
Sbjct 114 VYSVELAEANAANARQIWAHAGVADRVTCVVGTIGDGGRTLDALATEHGFAPGALDFVFV 173
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDKKAYL DLQSILDR WLH GSIVVADNV+VPGAP+Y YMR QG W+T EHKTHL
Sbjct 174 DHDKKAYLDDLQSILDREWLHRGSIVVADNVKVPGAPEYHEYMRHHQGTLWDTTEHKTHL 233
Query 180 EYQTLVPDLVLESEYLG 196
EYQTLV DLVLES+YLG
Sbjct 234 EYQTLVSDLVLESDYLG 250
>gi|296164602|ref|ZP_06847169.1| catechol-O-methyltransferase [Mycobacterium parascrofulaceum
ATCC BAA-614]
gi|295900021|gb|EFG79460.1| catechol-O-methyltransferase [Mycobacterium parascrofulaceum
ATCC BAA-614]
Length=250
Score = 317 bits (813), Expect = 4e-85, Method: Compositional matrix adjust.
Identities = 167/197 (85%), Positives = 180/197 (92%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATIDKFAYEKS+LINVGDEKG LDAAVRRADPA+ALELGTY+GYGALRIARAAP+A+
Sbjct 54 VLATIDKFAYEKSILINVGDEKGRFLDAAVRRADPAVALELGTYVGYGALRIARAAPQAK 113
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
VYSVELAEANA+NARRIWAHAGV DRV CVVGTIGDGGRTLDAL EHGFA G LDFVFL
Sbjct 114 VYSVELAEANAANARRIWAHAGVADRVTCVVGTIGDGGRTLDALAAEHGFAAGALDFVFL 173
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DL SI+ RGWL PG+IVVADNVRVPGAPKYRAYMR+QQG WNT+EHK HL
Sbjct 174 DHDKDAYLDDLHSIMARGWLRPGAIVVADNVRVPGAPKYRAYMRQQQGKRWNTVEHKAHL 233
Query 180 EYQTLVPDLVLESEYLG 196
EYQ+LV DLVLESE++G
Sbjct 234 EYQSLVSDLVLESEFVG 250
>gi|118617319|ref|YP_905651.1| O-methyltransferase [Mycobacterium ulcerans Agy99]
gi|118569429|gb|ABL04180.1| O-methyltransferase [Mycobacterium ulcerans Agy99]
Length=197
Score = 317 bits (813), Expect = 5e-85, Method: Compositional matrix adjust.
Identities = 167/197 (85%), Positives = 179/197 (91%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATIDKFAYEKS+L+NVGDEKG LLDAAVRRADPALALELGTY GYGALRIARAAP+A+
Sbjct 1 MLATIDKFAYEKSILVNVGDEKGLLLDAAVRRADPALALELGTYCGYGALRIARAAPQAK 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
VYSVELAEANA+NAR+IWAHAGV DRV CVVGTIGDGGRTLDAL TEHGFA G LDFVF+
Sbjct 61 VYSVELAEANAANARQIWAHAGVADRVTCVVGTIGDGGRTLDALATEHGFAPGALDFVFV 120
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDKKAYL DLQSILDR WLH GSIVVADNV+VPGAP+Y YMR QG W+T EHKTHL
Sbjct 121 DHDKKAYLDDLQSILDREWLHRGSIVVADNVKVPGAPEYHEYMRHHQGTLWDTTEHKTHL 180
Query 180 EYQTLVPDLVLESEYLG 196
EYQTLV DLVLES+YLG
Sbjct 181 EYQTLVSDLVLESDYLG 197
>gi|41407507|ref|NP_960343.1| hypothetical protein MAP1409c [Mycobacterium avium subsp. paratuberculosis
K-10]
gi|41395860|gb|AAS03726.1| hypothetical protein MAP_1409c [Mycobacterium avium subsp. paratuberculosis
K-10]
Length=234
Score = 311 bits (797), Expect = 3e-83, Method: Compositional matrix adjust.
Identities = 160/197 (82%), Positives = 177/197 (90%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATID+FAY+KSMLINVGDEKG +LDAAVRRADP +ALELGTY GYGALRIARAAP AR
Sbjct 38 VLATIDRFAYQKSMLINVGDEKGLILDAAVRRADPDVALELGTYCGYGALRIARAAPGAR 97
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
V+SVELA+ANA+NARRIWAHAGV DRV CVVGTIGDGGRTLD L EHGFA GTLDFVFL
Sbjct 98 VFSVELADANAANARRIWAHAGVADRVTCVVGTIGDGGRTLDVLANEHGFAAGTLDFVFL 157
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DL+SI+DRGWLHPGSIVVADN+R PG+PKYR YM QQG ++T+EHKTH
Sbjct 158 DHDKDAYLADLKSIMDRGWLHPGSIVVADNIRWPGSPKYREYMHVQQGKRFDTVEHKTHA 217
Query 180 EYQTLVPDLVLESEYLG 196
EYQT++ DL+LESEYLG
Sbjct 218 EYQTMLSDLMLESEYLG 234
>gi|120404255|ref|YP_954084.1| catechol O-methyltransferase [Mycobacterium vanbaalenii PYR-1]
gi|119957073|gb|ABM14078.1| Catechol O-methyltransferase [Mycobacterium vanbaalenii PYR-1]
Length=244
Score = 311 bits (796), Expect = 4e-83, Method: Compositional matrix adjust.
Identities = 149/196 (77%), Positives = 166/196 (85%), Gaps = 1/196 (0%)
Query 2 LATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARV 61
L+ ID FAY K+ML+N+GDEKG LLDAAVRRADPAL LELGTY GY ALRIARAAP ARV
Sbjct 48 LSAIDTFAYRKAMLVNIGDEKGALLDAAVRRADPALVLELGTYCGYSALRIARAAPSARV 107
Query 62 YSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALT-EHGFATGTLDFVFLD 120
SVE + ANA ARRIWAHAGV DRV CVVGT+GDGGRTLD L EHG TG++D +F+D
Sbjct 108 LSVEFSAANADVARRIWAHAGVGDRVTCVVGTLGDGGRTLDTLAREHGVTTGSVDLLFID 167
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HDKKAYL DL+S+ RGWLH GSIVVADNVRVPGAP YR +MR QQG WNT+EHKTH+E
Sbjct 168 HDKKAYLSDLRSVEQRGWLHRGSIVVADNVRVPGAPDYRRHMREQQGTRWNTVEHKTHVE 227
Query 181 YQTLVPDLVLESEYLG 196
YQ+L+PDLVLESEYLG
Sbjct 228 YQSLLPDLVLESEYLG 243
>gi|336457861|gb|EGO36855.1| putative O-methyltransferase [Mycobacterium avium subsp. paratuberculosis
S397]
Length=250
Score = 310 bits (794), Expect = 7e-83, Method: Compositional matrix adjust.
Identities = 160/197 (82%), Positives = 177/197 (90%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATID+FAY+KSMLINVGDEKG +LDAAVRRADP +ALELGTY GYGALRIARAAP AR
Sbjct 54 VLATIDRFAYQKSMLINVGDEKGLILDAAVRRADPDVALELGTYCGYGALRIARAAPGAR 113
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
V+SVELA+ANA+NARRIWAHAGV DRV CVVGTIGDGGRTLD L EHGFA GTLDFVFL
Sbjct 114 VFSVELADANAANARRIWAHAGVADRVTCVVGTIGDGGRTLDVLANEHGFAAGTLDFVFL 173
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DL+SI+DRGWLHPGSIVVADN+R PG+PKYR YM QQG ++T+EHKTH
Sbjct 174 DHDKDAYLADLKSIMDRGWLHPGSIVVADNIRWPGSPKYREYMHVQQGKRFDTVEHKTHA 233
Query 180 EYQTLVPDLVLESEYLG 196
EYQT++ DL+LESEYLG
Sbjct 234 EYQTMLSDLMLESEYLG 250
>gi|118464980|ref|YP_882253.1| catechol-O-methyltransferase [Mycobacterium avium 104]
gi|118166267|gb|ABK67164.1| catechol-O-methyltransferase [Mycobacterium avium 104]
Length=250
Score = 305 bits (782), Expect = 2e-81, Method: Compositional matrix adjust.
Identities = 161/197 (82%), Positives = 177/197 (90%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
VLATID+FAY+KSMLINVGDEKG +LDAAVRRADP +ALELGTY GYGALRIARAAP AR
Sbjct 54 VLATIDRFAYQKSMLINVGDEKGLILDAAVRRADPDVALELGTYCGYGALRIARAAPGAR 113
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
V+SVELAEANA+NARRIWAHAGV DRV CVVGTIGDGGRTLD L EHGFA GTLDFVFL
Sbjct 114 VFSVELAEANAANARRIWAHAGVADRVTCVVGTIGDGGRTLDVLANEHGFAAGTLDFVFL 173
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DL+SI+DRGWLHPGSIVVADN+R PG+PKYR YM QQG ++T+EHKTH
Sbjct 174 DHDKDAYLADLKSIMDRGWLHPGSIVVADNIRWPGSPKYREYMHVQQGKRFDTVEHKTHA 233
Query 180 EYQTLVPDLVLESEYLG 196
EYQT++ DL+LESEYLG
Sbjct 234 EYQTMLSDLMLESEYLG 250
>gi|254775521|ref|ZP_05217037.1| hypothetical protein MaviaA2_12751 [Mycobacterium avium subsp.
avium ATCC 25291]
Length=197
Score = 304 bits (779), Expect = 3e-81, Method: Compositional matrix adjust.
Identities = 160/197 (82%), Positives = 177/197 (90%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATID+FAY+KSMLINVGDEKG +LDAAVRRADP +ALELGTY GYGALRIARAAP AR
Sbjct 1 MLATIDRFAYQKSMLINVGDEKGLILDAAVRRADPDVALELGTYCGYGALRIARAAPGAR 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
V+SVELAEANA+NARRIWAHAGV DRV CVVGTIGDGGRTLD L EHGFA GTLDFVFL
Sbjct 61 VFSVELAEANAANARRIWAHAGVADRVTCVVGTIGDGGRTLDVLANEHGFAAGTLDFVFL 120
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDK AYL DL+SI+DRGWLHPGSIVVADN+R PG+PKYR YM QQG ++T+EHKTH
Sbjct 121 DHDKDAYLADLKSIMDRGWLHPGSIVVADNIRWPGSPKYREYMHVQQGKRFDTVEHKTHA 180
Query 180 EYQTLVPDLVLESEYLG 196
EYQT++ DL+LESEYLG
Sbjct 181 EYQTMLSDLMLESEYLG 197
>gi|240170157|ref|ZP_04748816.1| catechol-O-methyltransferase [Mycobacterium kansasii ATCC 12478]
Length=197
Score = 300 bits (768), Expect = 8e-80, Method: Compositional matrix adjust.
Identities = 167/197 (85%), Positives = 180/197 (92%), Gaps = 1/197 (0%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEAR 60
+LATID+FAYEKSMLIN+GDEKG +LDAA RRA+PALALELGTY GYGALRIARAAP AR
Sbjct 1 MLATIDRFAYEKSMLINIGDEKGPMLDAAARRANPALALELGTYCGYGALRIARAAPAAR 60
Query 61 VYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVFL 119
VYSVELAEANA+NAR+IWAHAGV DR+ CVVGTIGDGG TLDAL TEHGF +G LDFVF+
Sbjct 61 VYSVELAEANAANARQIWAHAGVADRITCVVGTIGDGGHTLDALATEHGFGSGALDFVFI 120
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DHDKK YL DLQSILDR WLHPGSIVVADNV VPGAPKYRAYMRR+QG WNT+EH+ HL
Sbjct 121 DHDKKVYLDDLQSILDRDWLHPGSIVVADNVLVPGAPKYRAYMRREQGRLWNTVEHRAHL 180
Query 180 EYQTLVPDLVLESEYLG 196
EYQTLVPDLVLESEYLG
Sbjct 181 EYQTLVPDLVLESEYLG 197
>gi|145224083|ref|YP_001134761.1| catechol O-methyltransferase [Mycobacterium gilvum PYR-GCK]
gi|315444420|ref|YP_004077299.1| O-methyltransferase [Mycobacterium sp. Spyr1]
gi|145216569|gb|ABP45973.1| Catechol O-methyltransferase [Mycobacterium gilvum PYR-GCK]
gi|315262723|gb|ADT99464.1| predicted O-methyltransferase [Mycobacterium sp. Spyr1]
Length=245
Score = 288 bits (736), Expect = 4e-76, Method: Compositional matrix adjust.
Identities = 139/195 (72%), Positives = 160/195 (83%), Gaps = 1/195 (0%)
Query 2 LATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARV 61
L+ ID FA +++L+NVG EKG LLDAAVRRADPALALELGTY GY ALRIARAAP ARV
Sbjct 48 LSAIDGFAVREAVLVNVGVEKGALLDAAVRRADPALALELGTYCGYSALRIARAAPSARV 107
Query 62 YSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALT-EHGFATGTLDFVFLD 120
SVE + ANA ARRIW HAGV DRV CVVGT+GDGGRTLD+L EHG G++D +F+D
Sbjct 108 LSVEFSAANAEVARRIWTHAGVADRVTCVVGTLGDGGRTLDSLAGEHGVGPGSVDLLFID 167
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
HD AYL DL SI RGWLH GS+VVADNVR+PGAP+YR YMR +G W+T+EHKTH+E
Sbjct 168 HDNSAYLSDLLSIEQRGWLHRGSLVVADNVRIPGAPEYRRYMREHEGTRWHTVEHKTHVE 227
Query 181 YQTLVPDLVLESEYL 195
YQ+L+PDLVLESEYL
Sbjct 228 YQSLLPDLVLESEYL 242
>gi|169628411|ref|YP_001702060.1| catechol-o-methyltransferase [Mycobacterium abscessus ATCC 19977]
gi|169240378|emb|CAM61406.1| Probable catechol-o-methyltransferase [Mycobacterium abscessus]
Length=253
Score = 275 bits (702), Expect = 3e-72, Method: Compositional matrix adjust.
Identities = 133/196 (68%), Positives = 157/196 (81%), Gaps = 2/196 (1%)
Query 2 LATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPEARV 61
+ ID FAY++S+L+NVGDEKG LLDAAV+RA+P +ALELG Y GY LRIARAAP A+
Sbjct 59 IEAIDNFAYDQSILMNVGDEKGQLLDAAVKRANPKIALELGAYCGYSGLRIARAAPGAKF 118
Query 62 YSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALT-EHGFATGTLDFVFLD 120
+S+E + ANAS ARR+WAHAG+ DR C+ GT D G TLD L ++GF G LDFVF+D
Sbjct 119 FSIEKSGANASVARRVWAHAGLADRATCLTGT-ADDGVTLDTLAKDYGFTEGCLDFVFID 177
Query 121 HDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHLE 180
H K YL DLQ +L+RGWLHPG+IVVADNVR PGAPKYRAYM+ QQG W TIEH+TH+E
Sbjct 178 HWKDIYLDDLQRLLERGWLHPGTIVVADNVRFPGAPKYRAYMKDQQGKLWQTIEHETHVE 237
Query 181 YQTLVPDLVLESEYLG 196
YQTLV DLVLESEYLG
Sbjct 238 YQTLVKDLVLESEYLG 253
>gi|317506730|ref|ZP_07964513.1| catechol O-methyltransferase [Segniliparus rugosus ATCC BAA-974]
gi|316254984|gb|EFV14271.1| catechol O-methyltransferase [Segniliparus rugosus ATCC BAA-974]
Length=244
Score = 227 bits (578), Expect = 8e-58, Method: Compositional matrix adjust.
Identities = 113/198 (58%), Positives = 142/198 (72%), Gaps = 3/198 (1%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V+ ID+F +++ L+NVGDEKG LLD AV RA P +ELG + GY LRIARA P A
Sbjct 44 VIKLIDEFGSKRAFLMNVGDEKGLLLDGAVARAQPRRLMELGAFCGYSGLRIARAMPPGA 103
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVF 118
+YSVE++ NA A IW HAGV DR+ VVG +GDG +TL L TE G +LDF+F
Sbjct 104 HLYSVEISPFNAQTATTIWQHAGVADRITAVVGALGDG-KTLGRLRTEFGLGPESLDFLF 162
Query 119 LDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTH 178
+DH+ YL DL+ +LD G+L G++VVADNV+VPGAPKY A+MR +G W T+EHKTH
Sbjct 163 IDHEHSVYLSDLELLLDAGFLREGAVVVADNVKVPGAPKYLAHMREHEGKDWRTVEHKTH 222
Query 179 LEYQTLVPDLVLESEYLG 196
LEYQ+ +PDLVLES YLG
Sbjct 223 LEYQSFIPDLVLESTYLG 240
>gi|209735740|gb|ACI68739.1| Catechol O-methyltransferase [Salmo salar]
Length=264
Score = 136 bits (342), Expect = 2e-30, Method: Compositional matrix adjust.
Identities = 81/197 (42%), Positives = 113/197 (58%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V++TID F +NVGDEKG +LD+ V P+ ALELGTY GY +RIAR P
Sbjct 75 VISTIDYFCRHSEWAMNVGDEKGAILDSVVCEVSPSTALELGTYCGYSTVRIARLLPPGT 134
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
++ ++E A+ AR+I ++G+ D++ V G GD L + F T DFVFL
Sbjct 135 KLITLEFNPDYAAVARQIIEYSGLQDKICLVEGASGD----LIPKMQELFGIKTFDFVFL 190
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD++ + + L GSI++ADNV PG P Y Y+R + + K+HL
Sbjct 191 DHWKDRYLPDIKLLEECQLLRKGSILLADNVICPGTPDYLEYVRNSP--RYESKYFKSHL 248
Query 180 EYQTLVPDLVLESEYLG 196
EY T V D + +S +LG
Sbjct 249 EY-TKVEDGLEKSVFLG 264
>gi|225708338|gb|ACO10015.1| Catechol O-methyltransferase [Osmerus mordax]
Length=263
Score = 135 bits (339), Expect = 4e-30, Method: Compositional matrix adjust.
Identities = 81/197 (42%), Positives = 112/197 (57%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V++ ID F +NVGDEKG +LD+ V PA ALELGTY GY ++RIAR P
Sbjct 74 VISAIDYFCRNSEWAMNVGDEKGPILDSVVCEVSPATALELGTYCGYSSVRIARLLPVGT 133
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
++ ++E A AR++ HAG++D++ V G GD L F T DFVFL
Sbjct 134 KLITLEFHPDYACIARQVIQHAGLEDKIFLVEGASGD----LIPKMADMFGISTFDFVFL 189
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPDL+ + + L GS+++ADNV PG P Y Y+R + + ++HL
Sbjct 190 DHWKDRYLPDLKLLEECQLLRKGSVLLADNVICPGTPDYLEYVRNSP--RYESRYFQSHL 247
Query 180 EYQTLVPDLVLESEYLG 196
EY T V D + +S +LG
Sbjct 248 EY-TKVEDGLEKSVFLG 263
>gi|317418959|emb|CBN80997.1| Catechol O-methyltransferase [Dicentrarchus labrax]
Length=264
Score = 134 bits (337), Expect = 7e-30, Method: Compositional matrix adjust.
Identities = 82/197 (42%), Positives = 115/197 (59%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+ ID+F K +NVGDEKG +LD+ V +PA LELGTY GY +RIA P A
Sbjct 75 VVKAIDQFCRNKEWAMNVGDEKGCILDSVVSEVNPAAVLELGTYCGYSTVRIASLLPPHA 134
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
++ ++E A+ AR++ A AG++++V V G GD + + E F TLD VFL
Sbjct 135 KLITLEFNPDFAAIARQVIAWAGLEEKVQLVEGASGDW---IPKMKEQ-FGVKTLDLVFL 190
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + + G L GS+++ADNV PG P Y Y+R + + K+HL
Sbjct 191 DHWKDRYLPDTKLMEECGLLRKGSVLLADNVICPGTPDYLEYVRSSP--RYESQYFKSHL 248
Query 180 EYQTLVPDLVLESEYLG 196
EY T V D + +S +LG
Sbjct 249 EY-TKVEDGLEKSVFLG 264
>gi|302795013|ref|XP_002979270.1| hypothetical protein SELMODRAFT_110441 [Selaginella moellendorffii]
gi|300153038|gb|EFJ19678.1| hypothetical protein SELMODRAFT_110441 [Selaginella moellendorffii]
Length=232
Score = 134 bits (337), Expect = 8e-30, Method: Compositional matrix adjust.
Identities = 70/192 (37%), Positives = 109/192 (57%), Gaps = 4/192 (2%)
Query 1 VLATIDKFAYEK-SMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAA--P 57
VL ID++ K + +N+GD+KG +LD+ V R++P LALELG Y GY A+RIA P
Sbjct 36 VLDVIDRYTASKGTWFMNIGDDKGPILDSVVERSNPRLALELGAYCGYSAVRIASRMKDP 95
Query 58 EARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFV 117
+ S+E+ N AR++ AG+ DRV + GT+ L ++ +D V
Sbjct 96 NGLLISIEMNPQNVQIARKMVEIAGLSDRVRVLEGTLESCLAELKSIIRDELQLSAIDLV 155
Query 118 FLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKT 177
F+DH+K YL D + + G L GS++VADN+ PG+P + Y+++ +T+EH+
Sbjct 156 FIDHNKNVYLKDYLQLKEEGLLKSGSVIVADNMGFPGSPSFWRYLKK-NAQELHTVEHRC 214
Query 178 HLEYQTLVPDLV 189
EY + D+V
Sbjct 215 KFEYIGWISDIV 226
>gi|302813782|ref|XP_002988576.1| hypothetical protein SELMODRAFT_128236 [Selaginella moellendorffii]
gi|300143683|gb|EFJ10372.1| hypothetical protein SELMODRAFT_128236 [Selaginella moellendorffii]
Length=221
Score = 133 bits (335), Expect = 1e-29, Method: Compositional matrix adjust.
Identities = 70/192 (37%), Positives = 109/192 (57%), Gaps = 4/192 (2%)
Query 1 VLATIDKFAYEK-SMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAA--P 57
VL ID++ K + +N+GD+KG +LD+ V R++P LALELG Y GY A+RIA P
Sbjct 25 VLDVIDRYTASKGTWFMNIGDDKGPILDSVVERSNPRLALELGAYCGYSAVRIASRMKDP 84
Query 58 EARVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFV 117
+ S+E+ N AR++ AG+ DRV + GT+ L ++ +D V
Sbjct 85 NGLLISIEMNPQNVEIARKMVEIAGLSDRVRVLEGTLETCLAELKSIIRDELQLSAIDLV 144
Query 118 FLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKT 177
F+DH+K YL D + + G L GS++VADN+ PG+P + Y+++ +T+EH+
Sbjct 145 FIDHNKNVYLKDYLQLKEEGLLKSGSVIVADNMGFPGSPSFWRYLKK-NAQELHTVEHRC 203
Query 178 HLEYQTLVPDLV 189
EY + D+V
Sbjct 204 KFEYIGWISDIV 215
>gi|332634793|ref|NP_001025328.2| catechol-O-methyltransferase a [Danio rerio]
gi|304651056|gb|ADM47479.1| catechol O-methyltransferase [Danio rerio]
Length=256
Score = 132 bits (333), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 80/197 (41%), Positives = 118/197 (60%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+A ID + +NVGDEKG +LD+ V +P+ ALELGTY GY +RIAR +P
Sbjct 67 VIAAIDHYCRHSEWAMNVGDEKGLILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGT 126
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
++ ++E A+ AR+I A+AG+ D+V+ V G GD + +HG + DFVFL
Sbjct 127 KLITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMKQ--QHGIK--SFDFVFL 182
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y+PD + + + G L GS+++ADNV PG P+Y Y+R + + K++L
Sbjct 183 DHWKDRYVPDTKLLEECGLLRKGSVLLADNVICPGTPEYLKYVRNDP--RYESRYFKSNL 240
Query 180 EYQTLVPDLVLESEYLG 196
EY T V D + +S +LG
Sbjct 241 EY-TKVEDGLEKSVFLG 256
>gi|169158753|emb|CAQ14945.1| novel protein similar to vertebrate catechol-O-methyltransferase
(COMT) [Danio rerio]
Length=277
Score = 132 bits (333), Expect = 2e-29, Method: Compositional matrix adjust.
Identities = 80/197 (41%), Positives = 118/197 (60%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+A ID + +NVGDEKG +LD+ V +P+ ALELGTY GY +RIAR +P
Sbjct 88 VIAAIDHYCRHSEWAMNVGDEKGLILDSVVTEVNPSTALELGTYCGYSTVRIARLLSPGT 147
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
++ ++E A+ AR+I A+AG+ D+V+ V G GD + +HG + DFVFL
Sbjct 148 KLITLEFNPDYAAIARQIIAYAGLQDKVILVEGPSGDLIPKMK--QQHGIK--SFDFVFL 203
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y+PD + + + G L GS+++ADNV PG P+Y Y+R + + K++L
Sbjct 204 DHWKDRYVPDTKLLEECGLLRKGSVLLADNVICPGTPEYLKYVRNDP--RYESRYFKSNL 261
Query 180 EYQTLVPDLVLESEYLG 196
EY T V D + +S +LG
Sbjct 262 EY-TKVEDGLEKSVFLG 277
>gi|139949106|ref|NP_001077312.1| catechol O-methyltransferase [Danio rerio]
gi|134024978|gb|AAI34932.1| Si:dkey-13a21.15 protein [Danio rerio]
Length=264
Score = 132 bits (332), Expect = 3e-29, Method: Compositional matrix adjust.
Identities = 81/197 (42%), Positives = 113/197 (58%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V++ ID F + +NVGDEKG +LD+ V +P LELGTY GY +RIAR P A
Sbjct 75 VISAIDHFCRHREWAMNVGDEKGCILDSVVSELNPEKVLELGTYCGYSTVRIARLLPPGA 134
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E A AR++ A AG++D+V V G D + + EH F T D VFL
Sbjct 135 RLITLEFNPDYAVIARQVIAWAGIEDKVQLVEGASEDW---IPRMKEH-FGIETFDLVFL 190
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PG P Y Y+R + S+ + K+HL
Sbjct 191 DHWKDHYLPDTKLMEGCGLLRKGTVLLADNVICPGVPDYLEYVRNSR--SYKSCYFKSHL 248
Query 180 EYQTLVPDLVLESEYLG 196
EY T D + +S +LG
Sbjct 249 EY-TRAEDGLEKSVFLG 264
>gi|33468632|emb|CAE30427.1| novel protein similar to human and rodent catechol-O-methyltransferase
(COMT) [Danio rerio]
Length=207
Score = 132 bits (332), Expect = 3e-29, Method: Compositional matrix adjust.
Identities = 81/197 (42%), Positives = 113/197 (58%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V++ ID F + +NVGDEKG +LD+ V +P LELGTY GY +RIAR P A
Sbjct 18 VISAIDHFCRHREWAMNVGDEKGCILDSVVSELNPEKVLELGTYCGYSTVRIARLLPPGA 77
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E A AR++ A AG++D+V V G D + + EH F T D VFL
Sbjct 78 RLITLEFNPDYAVIARQVIAWAGIEDKVQLVEGASEDW---IPRMKEH-FGIETFDLVFL 133
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PG P Y Y+R + S+ + K+HL
Sbjct 134 DHWKDHYLPDTKLMEGWGLLRKGTVLLADNVICPGVPDYLEYVRNSR--SYKSCYFKSHL 191
Query 180 EYQTLVPDLVLESEYLG 196
EY T D + +S +LG
Sbjct 192 EY-TRAEDGLEKSVFLG 207
>gi|148227708|ref|NP_001079715.1| similar to catecholamine-O-methyltransferase [Xenopus laevis]
gi|29351566|gb|AAH49292.1| MGC53924 protein [Xenopus laevis]
Length=261
Score = 132 bits (331), Expect = 3e-29, Method: Compositional matrix adjust.
Identities = 73/182 (41%), Positives = 105/182 (58%), Gaps = 7/182 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARA-APEA 59
V+ +DK+ +K +NVGDEKG +LD V+ +P+ LELGTY GY A+RI R+ P A
Sbjct 72 VIDNVDKYCSQKEWSMNVGDEKGVILDNIVKETNPSTLLELGTYCGYSAIRICRSLKPGA 131
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R ++VE A A+ A+++ AG+ D+V + G+ D L + + TLDFVF+
Sbjct 132 RFFTVEFNPAYAAVAKQMIEFAGLKDKVQVLEGSTSDIIPQL----KKKYEVETLDFVFV 187
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y PD Q + L GS+V+ADNV VPGAP + Y+R ++ + L
Sbjct 188 DHWKDKYKPDTQLLEKCNLLRKGSVVLADNVIVPGAPDFLEYVR--NCGKYDCTNFPSFL 245
Query 180 EY 181
EY
Sbjct 246 EY 247
>gi|224071830|ref|XP_002198695.1| PREDICTED: catechol-O-methyltransferase isoform 1 [Taeniopygia
guttata]
gi|224071834|ref|XP_002198702.1| PREDICTED: catechol-O-methyltransferase isoform 2 [Taeniopygia
guttata]
Length=262
Score = 130 bits (327), Expect = 1e-28, Method: Compositional matrix adjust.
Identities = 76/197 (39%), Positives = 114/197 (58%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V+ TIDK+ +K +NVGDEKG +LD V+ A+P++ALELGTY GY A+RI+R A
Sbjct 73 VVDTIDKYCSQKEWAMNVGDEKGKILDKTVQEANPSVALELGTYCGYSAVRISRLLKAGA 132
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ +VE A+ A+++ AGV D+V + G + + + TLDFVFL
Sbjct 133 RLLTVEFNPEFAAIAKQMIEFAGVQDKVKLLEGP----SEEIIPQLKKKYEVDTLDFVFL 188
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y PD + + L GS+++ADN+ PGAP + Y+R+ + + +HL
Sbjct 189 DHWKDRYTPDTILLQECNLLRKGSVLLADNIIFPGAPDFLNYVRKSP--HFQCTNYPSHL 246
Query 180 EYQTLVPDLVLESEYLG 196
EY V D + ++ +LG
Sbjct 247 EYMQ-VEDAMEKAVFLG 262
>gi|62858577|ref|NP_001016357.1| catechol-O-methyltransferase [Xenopus (Silurana) tropicalis]
gi|89266982|emb|CAJ82038.1| novel protein similar to catechol-O-methyltransferase comt [Xenopus
(Silurana) tropicalis]
Length=261
Score = 130 bits (326), Expect = 1e-28, Method: Compositional matrix adjust.
Identities = 73/182 (41%), Positives = 105/182 (58%), Gaps = 7/182 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+ IDK+ ++ +NVG+EKG +LD V+ ++P+ LELGTY GY A+RI R P
Sbjct 72 VIDNIDKYCSQREWSMNVGNEKGIILDNVVKESNPSTILELGTYCGYSAVRICRLLKPGV 131
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R ++VE A A+ A++I AG+ D+V + G+ GD L + + TLDFVF+
Sbjct 132 RFFTVEFNPAYAAVAKQIIEFAGLIDKVQVLEGSTGDIIPQL----KKKYEVDTLDFVFV 187
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y PD Q + L GS+V+ADNV VPGAP + Y+R ++ + L
Sbjct 188 DHWKDKYKPDTQLLEKCNLLRKGSVVLADNVIVPGAPDFLEYVR--NCGKYDCTNFPSFL 245
Query 180 EY 181
EY
Sbjct 246 EY 247
>gi|148236243|ref|NP_001090344.1| catechol-O-methyltransferase [Xenopus laevis]
gi|114108079|gb|AAI23207.1| Comt protein [Xenopus laevis]
Length=214
Score = 129 bits (325), Expect = 2e-28, Method: Compositional matrix adjust.
Identities = 73/182 (41%), Positives = 110/182 (61%), Gaps = 7/182 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+ ID++ +K +NVGDEKG +LD ++ +P + LELGTY GY A+RIAR P A
Sbjct 25 VIDHIDEYCSKKEWAMNVGDEKGLILDQVLKETEPLVVLELGTYCGYSAIRIARLLKPSA 84
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ +VE+ NAS A+++ AGV+++V ++G+ L TEHG DFVF+
Sbjct 85 RLLTVEINPDNASIAKQMIEFAGVENKVQILLGSTETVIPQLK--TEHG--VKHFDFVFI 140
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y+PD + + G L GS+++ADNV PGAP++ Y+R ++ + H+
Sbjct 141 DHFKIRYVPDTILLEECGLLRKGSVLLADNVVQPGAPEFLKYVR--TSGRYDCTNYPAHV 198
Query 180 EY 181
EY
Sbjct 199 EY 200
>gi|209736918|gb|ACI69328.1| Catechol O-methyltransferase [Salmo salar]
Length=266
Score = 129 bits (325), Expect = 2e-28, Method: Compositional matrix adjust.
Identities = 77/197 (40%), Positives = 113/197 (58%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V+ ID F + +NVGDEKG++LD+ V P LELGTY GY +RIAR P A
Sbjct 76 VITAIDHFCRHREWAMNVGDEKGSILDSVVSEVSPVTVLELGTYCGYSTVRIARLLPPGA 135
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
V ++E A+ AR++ +G++D+V V G GD + + EH F D VFL
Sbjct 136 CVITLEFNPDYAAIARQVIQWSGLEDKVQLVEGASGDW---IPWMKEH-FGVQAFDLVFL 191
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K+ YLPD + + + G + G++++ADNV PG P Y Y+R +N+ +++HL
Sbjct 192 DHWKERYLPDTKLLEECGLIQKGTVLLADNVICPGTPDYLEYVRNSP--RYNSHYYRSHL 249
Query 180 EYQTLVPDLVLESEYLG 196
EY T D + +S +LG
Sbjct 250 EY-TKAEDGLEKSVFLG 265
>gi|167621424|ref|NP_001108007.1| catechol O-methyltransferase isoform S-COMT [Equus caballus]
gi|58531102|dbj|BAD89295.1| catechol O-methyltransferase, soluble form [Equus caballus]
Length=222
Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust.
Identities = 79/197 (41%), Positives = 113/197 (58%), Gaps = 7/197 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
VL TID + +K +NVGD+KG LDA V+ P++ LELG Y GY A+R+AR P A
Sbjct 25 VLETIDAYCSQKEWAMNVGDKKGQFLDAVVQEQQPSVLLELGAYCGYSAVRMARLLPPGA 84
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +R+ AG+ DRV V+G D L + + TLD VFL
Sbjct 85 RLLTIEINPDYAAITQRMLDFAGLQDRVTVVLGASQDIIPQL----KKKYDVDTLDVVFL 140
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV VPGAP + A++R + ++L
Sbjct 141 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGAPDFLAHVRGSG--RFECTHFSSYL 198
Query 180 EYQTLVPDLVLESEYLG 196
EY V D V ++ YLG
Sbjct 199 EYSLWVVDGVEKAVYLG 215
>gi|126352448|ref|NP_001075303.1| catechol O-methyltransferase isoform MB-COMT [Equus caballus]
gi|75052801|sp|Q5H879.1|COMT_HORSE RecName: Full=Catechol O-methyltransferase
gi|58531101|dbj|BAD89294.1| catechol O-methyltransferase, membrane-bound form [Equus caballus]
Length=269
Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust.
Identities = 79/197 (41%), Positives = 113/197 (58%), Gaps = 7/197 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
VL TID + +K +NVGD+KG LDA V+ P++ LELG Y GY A+R+AR P A
Sbjct 72 VLETIDAYCSQKEWAMNVGDKKGQFLDAVVQEQQPSVLLELGAYCGYSAVRMARLLPPGA 131
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +R+ AG+ DRV V+G D L + + TLD VFL
Sbjct 132 RLLTIEINPDYAAITQRMLDFAGLQDRVTVVLGASQDIIPQL----KKKYDVDTLDVVFL 187
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV VPGAP + A++R + ++L
Sbjct 188 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGAPDFLAHVRGSG--RFECTHFSSYL 245
Query 180 EYQTLVPDLVLESEYLG 196
EY V D V ++ YLG
Sbjct 246 EYSLWVVDGVEKAVYLG 262
>gi|296191360|ref|XP_002743590.1| PREDICTED: catechol O-methyltransferase-like [Callithrix jacchus]
Length=268
Score = 129 bits (323), Expect = 3e-28, Method: Compositional matrix adjust.
Identities = 73/186 (40%), Positives = 111/186 (60%), Gaps = 7/186 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
VL ID + +K +NVGD+KG ++DA ++ P++ LELG Y GY A+R+AR +P A
Sbjct 72 VLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEYQPSVLLELGAYCGYSAVRMARLLSPSA 131
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++EL+ A A+ +R+ AGV D+V VVG D L + + TLD VFL
Sbjct 132 RLLTIELSPAYAAITQRMVDFAGVQDKVTVVVGASQDIIPQL----KKKYDVDTLDMVFL 187
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PGAP++ A++R + + + L
Sbjct 188 DHWKDRYLPDTILLEECGLLRKGTVLLADNVICPGAPEFLAHVRGSS--CFECTNYPSFL 245
Query 180 EYQTLV 185
EY+ +V
Sbjct 246 EYRNVV 251
>gi|326929526|ref|XP_003210914.1| PREDICTED: catechol O-methyltransferase-like [Meleagris gallopavo]
Length=262
Score = 128 bits (321), Expect = 5e-28, Method: Compositional matrix adjust.
Identities = 76/197 (39%), Positives = 110/197 (56%), Gaps = 8/197 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
V+ TIDK+ EK +NVGD KG +LD V +P +ALELGTY GY A+RIAR +
Sbjct 73 VMETIDKYCSEKEWAMNVGDVKGVILDKTVEEINPKVALELGTYCGYSAVRIARLLKAGS 132
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ +VE A+ A+++ AGV D+V + G + + + TLDFVFL
Sbjct 133 RLLTVEFNPEFAAIAKQMIEFAGVQDKVKLLEGP----SEVIIPQLKKKYEVDTLDFVFL 188
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y PD + + L GS+++ADN+ PGAP++ Y+R T + +HL
Sbjct 189 DHWKDRYAPDTILLQECSLLRKGSVLLADNIIFPGAPEFVKYIRNNPRFQCRT--YPSHL 246
Query 180 EYQTLVPDLVLESEYLG 196
EY V D + ++ +LG
Sbjct 247 EYMK-VQDAMEKAVFLG 262
>gi|168028905|ref|XP_001766967.1| predicted protein [Physcomitrella patens subsp. patens]
gi|162681709|gb|EDQ68133.1| predicted protein [Physcomitrella patens subsp. patens]
Length=261
Score = 127 bits (318), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 71/213 (34%), Positives = 116/213 (55%), Gaps = 22/213 (10%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAA--PE 58
VL ++ F +++ L+ +GDEKG LLD+ V +P +ALELG Y GY A RIA P
Sbjct 51 VLEAVNDFC-KRTWLMCIGDEKGALLDSCVLHRNPRVALELGAYCGYSATRIASQMKEPA 109
Query 59 ARVYSVELAEANASNARRIWAHAG-----------------VDDRVVCVVGTIGDGGRTL 101
+ + S+E+ N AR++ HAG + RV + G + + + L
Sbjct 110 SMLISLEMNATNVDTARQLINHAGFSSRERTSDSHSAFAEGLSSRVRVINGVLSEKLQEL 169
Query 102 DALTEHGFATGTLDFVFLDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAY 161
+ + T +FVF+DH+K +YL D + + G + G+++VADN++ PG+PKYR Y
Sbjct 170 RNIL-NSLKTNIFEFVFIDHNKDSYLSDFLLLKENGLIGKGTVIVADNMKFPGSPKYRRY 228
Query 162 MRRQQGMSWNTIEHKTHLEYQTLVPDLVLESEY 194
+R+ + T+E K EY + +PD ++ S +
Sbjct 229 LRKHSE-EFETVELKCAFEYISWLPDSLMVSTW 260
>gi|47209089|emb|CAF90723.1| unnamed protein product [Tetraodon nigroviridis]
Length=253
Score = 126 bits (317), Expect = 1e-27, Method: Compositional matrix adjust.
Identities = 77/198 (39%), Positives = 109/198 (56%), Gaps = 8/198 (4%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
+L D + + + N+G +KG +LD + P LELG + GY +RIARA P A
Sbjct 61 ILNAFDMWCSKVEFISNIGPKKGKILDRLLLDYSPLTVLELGAHCGYSTVRIARALPPGA 120
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDAL-TEHGFATGTLDFVF 118
R+YS+E+ + NA+ A +I AG DD V ++ D + + +E+G LDFVF
Sbjct 121 RLYSIEMDQNNAAIAEKIIRLAGFDDNTVELIVNPSD--EVIPKMHSEYGLER--LDFVF 176
Query 119 LDHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTH 178
+DH KK Y PDLQ + G LH GS++VADNV PGAPK+ ++R W H+
Sbjct 177 MDHWKKCYSPDLQMLEGSGLLHKGSVIVADNVLFPGAPKFLRHVRESGLYDWKV--HRAT 234
Query 179 LEYQTLVPDLVLESEYLG 196
LEY + D + E Y G
Sbjct 235 LEYSKGIRDGMAELVYKG 252
>gi|166157808|ref|NP_001107540.1| hypothetical protein LOC100135405 [Xenopus (Silurana) tropicalis]
gi|163915896|gb|AAI57796.1| LOC100135405 protein [Xenopus (Silurana) tropicalis]
gi|213627364|gb|AAI71189.1| hypothetical protein LOC100135405 [Xenopus (Silurana) tropicalis]
gi|213627366|gb|AAI71195.1| hypothetical protein LOC100135405 [Xenopus (Silurana) tropicalis]
Length=214
Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust.
Identities = 71/182 (40%), Positives = 109/182 (60%), Gaps = 7/182 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+ ID++ +K +NVGDEKG +LD ++ +P LELGTY GY A+RIAR P A
Sbjct 25 VIDHIDEYCSKKEWAMNVGDEKGLILDQVLKETEPLEVLELGTYCGYSAIRIARLLKPGA 84
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ +VE+ NAS A+++ AGV+D+V ++G+ L T+HG DFVF+
Sbjct 85 RLLTVEINPDNASVAKQMIQFAGVEDKVQILLGSTETVIPNLR--TQHG--VKHFDFVFI 140
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K Y PD + + G L G++++ADNV +PGAP++ ++R ++ + H+
Sbjct 141 DHFKNRYSPDTMLLEEYGLLRKGTVLLADNVVLPGAPEFLEHVR--TSGRYDCTNYPAHV 198
Query 180 EY 181
EY
Sbjct 199 EY 200
>gi|161484634|ref|NP_031770.2| catechol O-methyltransferase [Mus musculus]
gi|161484636|ref|NP_001104532.1| catechol O-methyltransferase [Mus musculus]
gi|161484638|ref|NP_001104533.1| catechol O-methyltransferase [Mus musculus]
gi|14714535|gb|AAH10402.1| Catechol-O-methyltransferase 1 [Mus musculus]
gi|74201722|dbj|BAE28473.1| unnamed protein product [Mus musculus]
Length=265
Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust.
Identities = 72/186 (39%), Positives = 107/186 (58%), Gaps = 7/186 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
VL ID + EK +NVGD KG ++DA +R P+L LELG Y GY A+R+AR P A
Sbjct 68 VLEAIDTYCSEKEWAMNVGDAKGQIMDAVIREYRPSLVLELGAYCGYSAVRMARLLPPGA 127
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +++ AG+ D+V ++G D L + + TLD VFL
Sbjct 128 RLLTMEINPDYAAITQQMLDFAGLQDKVSILIGASQD----LIPQLKKKYDVDTLDMVFL 183
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV VPG P + AY+R S+ + ++L
Sbjct 184 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSS--SFECTHYSSYL 241
Query 180 EYQTLV 185
EY +V
Sbjct 242 EYMKVV 247
>gi|5921831|sp|O88587.1|COMT_MOUSE RecName: Full=Catechol O-methyltransferase
gi|3493253|gb|AAC33334.1| catechol-O-methyltransferase [Mus musculus]
Length=265
Score = 125 bits (315), Expect = 2e-27, Method: Compositional matrix adjust.
Identities = 72/186 (39%), Positives = 107/186 (58%), Gaps = 7/186 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
VL ID + EK +NVGD KG ++DA +R P+L LELG Y GY A+R+AR P A
Sbjct 68 VLEAIDTYCSEKEWAMNVGDAKGQIMDAVIREYRPSLVLELGAYCGYSAVRMARLLPPGA 127
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +++ AG+ D+V ++G D L + + TLD VFL
Sbjct 128 RLLTMEINPDYAAITQQMLDFAGLQDKVSILIGAPQD----LIPQLKKKYDVDTLDMVFL 183
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV VPG P + AY+R S+ + ++L
Sbjct 184 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSS--SFECTHYSSYL 241
Query 180 EYQTLV 185
EY +V
Sbjct 242 EYMKVV 247
>gi|109093290|ref|XP_001105683.1| PREDICTED: catechol O-methyltransferase-like isoform 2 [Macaca
mulatta]
Length=270
Score = 125 bits (313), Expect = 5e-27, Method: Compositional matrix adjust.
Identities = 70/186 (38%), Positives = 110/186 (60%), Gaps = 7/186 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
V+ ID + +K +NVGD+KG ++DA ++ P++ LELG Y GY A+R+AR +P A
Sbjct 74 VVEAIDTYCQQKEWAMNVGDKKGKIVDAVIQEHQPSMLLELGAYCGYSAVRMARLLSPGA 133
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +R+ AG+ D+V VVG D L + + TLD VFL
Sbjct 134 RLLTIEINPDYAAITQRMVDFAGMQDKVTVVVGASQDIIPQL----KKKYDVDTLDMVFL 189
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PGAP + A++RR + +++ L
Sbjct 190 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRRSN--RFECTHYQSFL 247
Query 180 EYQTLV 185
EY+ +V
Sbjct 248 EYRKVV 253
>gi|126344631|ref|XP_001380438.1| PREDICTED: catechol O-methyltransferase-like [Monodelphis domestica]
Length=315
Score = 124 bits (311), Expect = 7e-27, Method: Compositional matrix adjust.
Identities = 68/164 (42%), Positives = 98/164 (60%), Gaps = 5/164 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIARAAPE-A 59
VL ID + Y +NVGD KG ++D V A P + LELGTY GY A+R+AR P A
Sbjct 126 VLDAIDYYCYNTEWAMNVGDIKGVIMDRIVEEAKPRVLLELGTYCGYSAIRMARLLPPGA 185
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R++++E E+ AS A ++ AG+ D++ + G+ + L E T+D VFL
Sbjct 186 RLFTIEFNESFASIASQMIQLAGLQDKISILKGSTQEIIPQLKKKHE----ISTVDLVFL 241
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMR 163
DH K YLPD Q +L+ G L GS+++ADNV PGAP++ ++R
Sbjct 242 DHWKDRYLPDTQLLLESGLLRKGSVLLADNVICPGAPEFLQFVR 285
>gi|189339616|pdb|3BWM|A Chain A, Crystal Structure Of Human Catechol O-Methyltransferase
With Bound Sam And Dnc
Length=214
Score = 124 bits (311), Expect = 8e-27, Method: Compositional matrix adjust.
Identities = 72/189 (39%), Positives = 110/189 (59%), Gaps = 7/189 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
VL ID + +K +NVGD+KG ++DA ++ P++ LELG Y GY A+R+AR +P A
Sbjct 24 VLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGA 83
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +R+ AGV D+V VVG D L + + TLD VFL
Sbjct 84 RLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQL----KKKYDVDTLDMVFL 139
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PGAP + A++R + +++ L
Sbjct 140 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSS--CFECTHYQSFL 197
Query 180 EYQTLVPDL 188
EY+ +V L
Sbjct 198 EYREVVDGL 206
>gi|6466450|ref|NP_009294.1| catechol O-methyltransferase isoform S-COMT [Homo sapiens]
Length=221
Score = 124 bits (311), Expect = 8e-27, Method: Compositional matrix adjust.
Identities = 71/186 (39%), Positives = 109/186 (59%), Gaps = 7/186 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
VL ID + +K +NVGD+KG ++DA ++ P++ LELG Y GY A+R+AR +P A
Sbjct 25 VLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGA 84
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +R+ AGV D+V VVG D L + + TLD VFL
Sbjct 85 RLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQL----KKKYDVDTLDMVFL 140
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PGAP + A++R + +++ L
Sbjct 141 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSS--CFECTHYQSFL 198
Query 180 EYQTLV 185
EY+ +V
Sbjct 199 EYREVV 204
>gi|306991591|pdb|3A7E|A Chain A, Crystal Structure Of Human Comt Complexed With Sam And
3,5- Dinitrocatechol
Length=216
Score = 124 bits (311), Expect = 8e-27, Method: Compositional matrix adjust.
Identities = 72/189 (39%), Positives = 110/189 (59%), Gaps = 7/189 (3%)
Query 1 VLATIDKFAYEKSMLINVGDEKGTLLDAAVRRADPALALELGTYLGYGALRIAR-AAPEA 59
VL ID + +K +NVGD+KG ++DA ++ P++ LELG Y GY A+R+AR +P A
Sbjct 27 VLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGA 86
Query 60 RVYSVELAEANASNARRIWAHAGVDDRVVCVVGTIGDGGRTLDALTEHGFATGTLDFVFL 119
R+ ++E+ A+ +R+ AGV D+V VVG D L + + TLD VFL
Sbjct 87 RLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQL----KKKYDVDTLDMVFL 142
Query 120 DHDKKAYLPDLQSILDRGWLHPGSIVVADNVRVPGAPKYRAYMRRQQGMSWNTIEHKTHL 179
DH K YLPD + + G L G++++ADNV PGAP + A++R + +++ L
Sbjct 143 DHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSS--CFECTHYQSFL 200
Query 180 EYQTLVPDL 188
EY+ +V L
Sbjct 201 EYREVVDGL 209
Lambda K H
0.320 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 205411802368
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
Posted date: Sep 5, 2011 4:36 AM
Number of letters in database: 5,219,829,388
Number of sequences in database: 15,229,318
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40