BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1716 Length=276 Score E Sequences producing significant alignments: (Bits) Value gi|15608854|ref|NP_216232.1| hypothetical protein Rv1716 [Mycoba... 564 6e-159 gi|307079722|ref|ZP_07488892.1| hypothetical protein TMKG_02223 ... 563 1e-158 gi|15841176|ref|NP_336213.1| hypothetical protein MT1755 [Mycoba... 561 5e-158 gi|289443175|ref|ZP_06432919.1| conserved hypothetical protein [... 560 1e-157 gi|289574384|ref|ZP_06454611.1| conserved hypothetical protein [... 558 2e-157 gi|148822922|ref|YP_001287676.1| hypothetical protein TBFG_11731... 558 5e-157 gi|340626723|ref|YP_004745175.1| hypothetical protein MCAN_17271... 556 9e-157 gi|308231908|ref|ZP_07414239.2| putative cyclase superfamily [My... 525 2e-147 gi|240169425|ref|ZP_04748084.1| hypothetical protein MkanA1_0893... 524 8e-147 gi|308369505|ref|ZP_07418057.2| putative cyclase superfamily [My... 523 1e-146 gi|296164611|ref|ZP_06847178.1| conserved hypothetical protein [... 511 3e-143 gi|289750273|ref|ZP_06509651.1| conserved hypothetical protein [... 431 5e-119 gi|148551008|ref|YP_001260438.1| cyclase family protein [Sphingo... 412 3e-113 gi|169631566|ref|YP_001705215.1| hypothetical protein MAB_4492c ... 409 2e-112 gi|332306827|ref|YP_004434678.1| cyclase family protein [Glaciec... 385 5e-105 gi|109898636|ref|YP_661891.1| putative cyclase [Pseudoalteromona... 385 5e-105 gi|11498799|ref|NP_070028.1| hypothetical protein AF1200 [Archae... 321 6e-86 gi|118592789|ref|ZP_01550178.1| hypothetical protein SIAM614_290... 289 2e-76 gi|339442508|ref|YP_004708513.1| hypothetical protein CXIVA_1445... 233 3e-59 gi|87122102|ref|ZP_01077986.1| hypothetical protein MED121_04133... 199 4e-49 gi|310657511|ref|YP_003935232.1| hypothetical protein CLOST_0197... 198 9e-49 gi|339441306|ref|YP_004707311.1| hypothetical protein CXIVA_0242... 168 9e-40 gi|313902911|ref|ZP_07836307.1| cyclase family protein [Thermaer... 157 2e-36 gi|317122308|ref|YP_004102311.1| cyclase family protein [Thermae... 153 2e-35 gi|300855541|ref|YP_003780525.1| putative cyclase [Clostridium l... 145 5e-33 gi|307298666|ref|ZP_07578469.1| cyclase family protein [Thermoto... 144 1e-32 gi|269792029|ref|YP_003316933.1| cyclase family protein [Therman... 142 7e-32 gi|289524300|ref|ZP_06441154.1| putative cyclase [Anaerobaculum ... 140 3e-31 gi|312880791|ref|ZP_07740591.1| cyclase family protein [Aminomon... 137 2e-30 gi|221632605|ref|YP_002521826.1| putative polyketide cyclase [Th... 131 9e-29 gi|221632604|ref|YP_002521825.1| putative polyketide cyclase [Th... 131 1e-28 gi|338813078|ref|ZP_08625218.1| putative cyclase [Acetonema long... 129 4e-28 gi|150388525|ref|YP_001318574.1| cyclase family protein [Alkalip... 127 3e-27 gi|284046452|ref|YP_003396792.1| cyclase family protein [Conexib... 126 3e-27 gi|167770182|ref|ZP_02442235.1| hypothetical protein ANACOL_0152... 123 3e-26 gi|325972419|ref|YP_004248610.1| cyclase family protein [Spiroch... 119 3e-25 gi|345004382|ref|YP_004807235.1| cyclase family protein [halophi... 119 5e-25 gi|110667888|ref|YP_657699.1| cyclase [Haloquadratum walsbyi DSM... 119 7e-25 gi|339728827|emb|CCC40003.1| cyclase family protein [Haloquadrat... 118 1e-24 gi|158319910|ref|YP_001512417.1| cyclase family protein [Alkalip... 117 2e-24 gi|315425928|dbj|BAJ47578.1| cyclase family protein [Candidatus ... 117 3e-24 gi|320159994|ref|YP_004173218.1| hypothetical protein ANT_05840 ... 115 6e-24 gi|218961867|ref|YP_001741642.1| putative cyclase [Candidatus Cl... 110 3e-22 gi|78187925|ref|YP_375968.1| hypothetical protein Plut_2083 [Chl... 101 1e-19 gi|331696441|ref|YP_004332680.1| cyclase family protein [Pseudon... 100 2e-19 gi|20808973|ref|NP_624144.1| hypothetical protein TTE2628 [Therm... 97.8 1e-18 gi|193213662|ref|YP_001999615.1| cyclase family protein [Chlorob... 97.8 1e-18 gi|325291131|ref|YP_004267312.1| cyclase family protein [Syntrop... 97.4 2e-18 gi|254478157|ref|ZP_05091539.1| Putative cyclase superfamily pro... 96.7 3e-18 gi|310780252|ref|YP_003968584.1| cyclase family protein [Ilyobac... 95.1 1e-17 >gi|15608854|ref|NP_216232.1| hypothetical protein Rv1716 [Mycobacterium tuberculosis H37Rv] gi|148661514|ref|YP_001283037.1| hypothetical protein MRA_1726 [Mycobacterium tuberculosis H37Ra] gi|167968671|ref|ZP_02550948.1| hypothetical protein MtubH3_11798 [Mycobacterium tuberculosis H37Ra] gi|307084301|ref|ZP_07493414.1| hypothetical protein TMLG_00699 [Mycobacterium tuberculosis SUMu012] gi|3261548|emb|CAA17613.1| CONSERVED HYPOTHETICAL PROTEIN [Mycobacterium tuberculosis H37Rv] gi|148505666|gb|ABQ73475.1| hypothetical protein MRA_1726 [Mycobacterium tuberculosis H37Ra] gi|308366090|gb|EFP54941.1| hypothetical protein TMLG_00699 [Mycobacterium tuberculosis SUMu012] Length=276 Score = 564 bits (1453), Expect = 6e-159, Method: Compositional matrix adjust. Identities = 276/276 (100%), Positives = 276/276 (100%), Gaps = 0/276 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV 276 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKAV 276 >gi|307079722|ref|ZP_07488892.1| hypothetical protein TMKG_02223 [Mycobacterium tuberculosis SUMu011] gi|308362471|gb|EFP51322.1| hypothetical protein TMKG_02223 [Mycobacterium tuberculosis SUMu011] Length=276 Score = 563 bits (1450), Expect = 1e-158, Method: Compositional matrix adjust. Identities = 275/275 (100%), Positives = 275/275 (100%), Gaps = 0/275 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 >gi|15841176|ref|NP_336213.1| hypothetical protein MT1755 [Mycobacterium tuberculosis CDC1551] gi|31792904|ref|NP_855397.1| hypothetical protein Mb1744 [Mycobacterium bovis AF2122/97] gi|121637624|ref|YP_977847.1| hypothetical protein BCG_1755 [Mycobacterium bovis BCG str. Pasteur 1173P2] 27 more sequence titles Length=276 Score = 561 bits (1445), Expect = 5e-158, Method: Compositional matrix adjust. Identities = 274/275 (99%), Positives = 274/275 (99%), Gaps = 0/275 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPH PA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 >gi|289443175|ref|ZP_06432919.1| conserved hypothetical protein [Mycobacterium tuberculosis T46] gi|289569767|ref|ZP_06449994.1| conserved hypothetical protein [Mycobacterium tuberculosis T17] gi|289416094|gb|EFD13334.1| conserved hypothetical protein [Mycobacterium tuberculosis T46] gi|289543521|gb|EFD47169.1| conserved hypothetical protein [Mycobacterium tuberculosis T17] Length=276 Score = 560 bits (1442), Expect = 1e-157, Method: Compositional matrix adjust. Identities = 273/275 (99%), Positives = 274/275 (99%), Gaps = 0/275 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYA+SPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPH PA Sbjct 121 VVNTGWHHKYADSAEYYAFSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 >gi|289574384|ref|ZP_06454611.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] gi|289538815|gb|EFD43393.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] Length=276 Score = 558 bits (1439), Expect = 2e-157, Method: Compositional matrix adjust. Identities = 273/275 (99%), Positives = 273/275 (99%), Gaps = 0/275 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GT IDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTQIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPH PA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 >gi|148822922|ref|YP_001287676.1| hypothetical protein TBFG_11731 [Mycobacterium tuberculosis F11] gi|253799245|ref|YP_003032246.1| hypothetical protein TBMG_02279 [Mycobacterium tuberculosis KZN 1435] gi|254550727|ref|ZP_05141174.1| hypothetical protein Mtube_09759 [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] 11 more sequence titles Length=276 Score = 558 bits (1437), Expect = 5e-157, Method: Compositional matrix adjust. Identities = 273/275 (99%), Positives = 273/275 (99%), Gaps = 0/275 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAW LGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWLLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPH PA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 >gi|340626723|ref|YP_004745175.1| hypothetical protein MCAN_17271 [Mycobacterium canettii CIPT 140010059] gi|340004913|emb|CCC44059.1| conserved hypothetical protein [Mycobacterium canettii CIPT 140010059] Length=276 Score = 556 bits (1434), Expect = 9e-157, Method: Compositional matrix adjust. Identities = 272/275 (99%), Positives = 273/275 (99%), Gaps = 0/275 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS Sbjct 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPH PA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAV EYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVCEYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 F+AFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA Sbjct 241 FSAFPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 >gi|308231908|ref|ZP_07414239.2| putative cyclase superfamily [Mycobacterium tuberculosis SUMu001] gi|308379010|ref|ZP_07484672.2| putative cyclase superfamily [Mycobacterium tuberculosis SUMu010] gi|308215652|gb|EFO75051.1| putative cyclase superfamily [Mycobacterium tuberculosis SUMu001] gi|308358531|gb|EFP47382.1| putative cyclase superfamily [Mycobacterium tuberculosis SUMu010] Length=258 Score = 525 bits (1353), Expect = 2e-147, Method: Compositional matrix adjust. Identities = 256/257 (99%), Positives = 257/257 (100%), Gaps = 0/257 (0%) Query 19 LSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLD 78 +SHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLD Sbjct 1 MSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLD 60 Query 79 EIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA 138 EIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA Sbjct 61 EIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA 120 Query 139 YSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQT 198 YSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQT Sbjct 121 YSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQT 180 Query 199 GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRL 258 GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRL Sbjct 181 GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRL 240 Query 259 VAIVDPTGSYRIETGKA 275 VAIVDPTGSYRIETGKA Sbjct 241 VAIVDPTGSYRIETGKA 257 >gi|240169425|ref|ZP_04748084.1| hypothetical protein MkanA1_08939 [Mycobacterium kansasii ATCC 12478] Length=274 Score = 524 bits (1349), Expect = 8e-147, Method: Compositional matrix adjust. Identities = 253/273 (93%), Positives = 262/273 (96%), Gaps = 0/273 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 M F WPLG AES LEFYDLSHPWGHGAPAWPYFEDV+IERLHGMAKSRVLTQKITTVMHS Sbjct 1 MAFTWPLGDAESKLEFYDLSHPWGHGAPAWPYFEDVKIERLHGMAKSRVLTQKITTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPK KWG+VTAEDL+ A+P+IRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKTKWGVVTAEDLEQASPEIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 +VNTGWHHKYADSAEYYAYSPGF K+AGEWFAAKGVKAVGTDTQALDHPLATAIAPH PA Sbjct 121 IVNTGWHHKYADSAEYYAYSPGFYKEAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 EAQGGLLPWAV EYE QTGRKVLDDFP+WEPCHRAILS+GIYGFENVGGDLDKVTGKRVT Sbjct 181 EAQGGLLPWAVSEYEQQTGRKVLDDFPEWEPCHRAILSKGIYGFENVGGDLDKVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETG 273 FAAFPWRWVGGDGCIVRLVAI DPTGSYRIETG Sbjct 241 FAAFPWRWVGGDGCIVRLVAIADPTGSYRIETG 273 >gi|308369505|ref|ZP_07418057.2| putative cyclase superfamily [Mycobacterium tuberculosis SUMu002] gi|308370799|ref|ZP_07422776.2| putative cyclase superfamily [Mycobacterium tuberculosis SUMu003] gi|308372035|ref|ZP_07427142.2| putative cyclase superfamily [Mycobacterium tuberculosis SUMu004] 11 more sequence titles Length=258 Score = 523 bits (1348), Expect = 1e-146, Method: Compositional matrix adjust. Identities = 255/257 (99%), Positives = 256/257 (99%), Gaps = 0/257 (0%) Query 19 LSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLD 78 +SHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLD Sbjct 1 MSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFLD 60 Query 79 EIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA 138 EIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA Sbjct 61 EIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA 120 Query 139 YSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQT 198 YSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPH PAEAQGGLLPWAVREYEAQT Sbjct 121 YSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHGPAEAQGGLLPWAVREYEAQT 180 Query 199 GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRL 258 GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRL Sbjct 181 GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRL 240 Query 259 VAIVDPTGSYRIETGKA 275 VAIVDPTGSYRIETGKA Sbjct 241 VAIVDPTGSYRIETGKA 257 >gi|296164611|ref|ZP_06847178.1| conserved hypothetical protein [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295900030|gb|EFG79469.1| conserved hypothetical protein [Mycobacterium parascrofulaceum ATCC BAA-614] Length=274 Score = 511 bits (1317), Expect = 3e-143, Method: Compositional matrix adjust. Identities = 245/273 (90%), Positives = 259/273 (95%), Gaps = 0/273 (0%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 M+ WPLG AE+ LEFYDLSHPWGHGAPAWPYFEDV+IERLH MA+SRVLTQK+TTVMHS Sbjct 1 MSITWPLGEAEAALEFYDLSHPWGHGAPAWPYFEDVKIERLHNMARSRVLTQKVTTVMHS 60 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIV 120 GTHIDAPAHVVEGTPFL EIPLSAFFGTGVVVSIPK KWG+VTAEDL+ A P+IRPGDIV Sbjct 61 GTHIDAPAHVVEGTPFLHEIPLSAFFGTGVVVSIPKDKWGVVTAEDLEKAAPEIRPGDIV 120 Query 121 VVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPA 180 VVNTGWHHKYADSAEYYAYSPGF K+AGEWFAAKGVKAVGTDTQALDHPLAT+IAPH PA Sbjct 121 VVNTGWHHKYADSAEYYAYSPGFYKEAGEWFAAKGVKAVGTDTQALDHPLATSIAPHGPA 180 Query 181 EAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVT 240 E GGLLPWAVREYEAQTGR+VLDDFP+WEPCHRAILS+GIYGFENVGGDLD+VTGKRVT Sbjct 181 EHNGGLLPWAVREYEAQTGRRVLDDFPEWEPCHRAILSKGIYGFENVGGDLDQVTGKRVT 240 Query 241 FAAFPWRWVGGDGCIVRLVAIVDPTGSYRIETG 273 FAAFPWRWVGGDGCIVRLVAIVDPTG YRIETG Sbjct 241 FAAFPWRWVGGDGCIVRLVAIVDPTGGYRIETG 273 >gi|289750273|ref|ZP_06509651.1| conserved hypothetical protein [Mycobacterium tuberculosis T92] gi|289690860|gb|EFD58289.1| conserved hypothetical protein [Mycobacterium tuberculosis T92] Length=246 Score = 431 bits (1109), Expect = 5e-119, Method: Compositional matrix adjust. Identities = 218/245 (89%), Positives = 222/245 (91%), Gaps = 5/245 (2%) Query 36 VQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGT-----PFLDEIPLSAFFGTGV 90 +QIERLHGMAKSRVLTQ+ H + P V T FLDEIPLSAFFGTGV Sbjct 1 MQIERLHGMAKSRVLTQRSPKDHHPSCNSRHPHRRVGVTWWKEHRFLDEIPLSAFFGTGV 60 Query 91 VVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAYSPGFDKKAGEW 150 VVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYA+SPGFDKKAGEW Sbjct 61 VVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYYAFSPGFDKKAGEW 120 Query 151 FAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWE 210 FAAKGVKAVGTDTQALDHPLATAIAPH PAEAQGGLLPWAVREYEAQTGRKVLDDFPDWE Sbjct 121 FAAKGVKAVGTDTQALDHPLATAIAPHGPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWE 180 Query 211 PCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRI 270 PCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRI Sbjct 181 PCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVDPTGSYRI 240 Query 271 ETGKA 275 ETGKA Sbjct 241 ETGKA 245 >gi|148551008|ref|YP_001260438.1| cyclase family protein [Sphingomonas wittichii RW1] gi|148503419|gb|ABQ71671.1| cyclase family protein [Sphingomonas wittichii RW1] Length=290 Score = 412 bits (1059), Expect = 3e-113, Method: Compositional matrix adjust. Identities = 199/261 (77%), Positives = 219/261 (84%), Gaps = 1/261 (0%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 LEFYDLSHPWG G P WPYFEDV+IERLHGM++S VLTQKITTVMHSGTHI+APAHVV G Sbjct 28 LEFYDLSHPWGLGQPCWPYFEDVKIERLHGMSRSGVLTQKITTVMHSGTHINAPAHVVPG 87 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 TPF+DE+PL FFGTGVVVSIPK KW ++TAEDL+NA P IR GDIV+VNTGWH Y D+ Sbjct 88 TPFMDEVPLPYFFGTGVVVSIPKKKWEVITAEDLENARPQIREGDIVIVNTGWHKYYGDN 147 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 YYAYSPGF K+AGEWF K VK G+DTQALDHPL TAI PH A GL+P E Sbjct 148 RHYYAYSPGFYKEAGEWFVQKKVKMCGSDTQALDHPLGTAIGPHGTG-APHGLIPQVNIE 206 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 YE TGRKV++DFP+WEPCH AILS GI GFENVGGD+DKVTGKRVTFAAFPWRW GDG Sbjct 207 YEQLTGRKVIEDFPEWEPCHNAILSAGICGFENVGGDIDKVTGKRVTFAAFPWRWKKGDG 266 Query 254 CIVRLVAIVDPTGSYRIETGK 274 CIVRLVAIVDPTG++RIETGK Sbjct 267 CIVRLVAIVDPTGNFRIETGK 287 >gi|169631566|ref|YP_001705215.1| hypothetical protein MAB_4492c [Mycobacterium abscessus ATCC 19977] gi|169243533|emb|CAM64561.1| Conserved hypothetical protein [Mycobacterium abscessus] Length=264 Score = 409 bits (1051), Expect = 2e-112, Method: Compositional matrix adjust. Identities = 198/262 (76%), Positives = 215/262 (83%), Gaps = 1/262 (0%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 L+FYDLSHPWG G P WPYFEDV+IERLH MA+S VLTQKITTVMHSGTHIDAPAHVV G Sbjct 3 LQFYDLSHPWGLGTPCWPYFEDVKIERLHNMARSGVLTQKITTVMHSGTHIDAPAHVVPG 62 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 TPFL+E+PL FFGTGVVVSIPK KW ++TAEDL+NA P IR GDIV+VNTGWH Y D+ Sbjct 63 TPFLEEVPLPNFFGTGVVVSIPKKKWEVITAEDLENARPQIREGDIVIVNTGWHRYYGDN 122 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 YYAY+PGF K AGEWF + VK VG+DTQALDHPL TAI PH A GL+P E Sbjct 123 RHYYAYAPGFYKDAGEWFVERKVKMVGSDTQALDHPLGTAIGPHGTG-APNGLIPQVNLE 181 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 YE TGRKV++DFP WEPCH AILS GI GFENVGGD+DKVTGKRVTFAAFPWRW GDG Sbjct 182 YEQLTGRKVIEDFPYWEPCHNAILSNGILGFENVGGDIDKVTGKRVTFAAFPWRWKKGDG 241 Query 254 CIVRLVAIVDPTGSYRIETGKA 275 CIVRLVAI DPTG YRIETG A Sbjct 242 CIVRLVAITDPTGEYRIETGTA 263 >gi|332306827|ref|YP_004434678.1| cyclase family protein [Glaciecola agarilytica 4H-3-7+YE-5] gi|332174156|gb|AEE23410.1| cyclase family protein [Glaciecola sp. 4H-3-7+YE-5] Length=291 Score = 385 bits (988), Expect = 5e-105, Method: Compositional matrix adjust. Identities = 184/266 (70%), Positives = 211/266 (80%), Gaps = 5/266 (1%) Query 9 AAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPA 68 + ++ ++FYDLSH WG G P WPYFEDV+IERLHG ++S VLTQKITTVMHSGTHIDAPA Sbjct 27 SNDTGMQFYDLSHEWGLGQPCWPYFEDVKIERLHGHSRSGVLTQKITTVMHSGTHIDAPA 86 Query 69 HVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHH 128 HVVEGTPF+D++PL FFG GVVVSIPK KW ++TAEDL+N P IR GDIV++NTGWHH Sbjct 87 HVVEGTPFMDQMPLPRFFGAGVVVSIPKKKWEVITAEDLENVRPKIREGDIVIINTGWHH 146 Query 129 KYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLP 188 YADSAEYY Y PG ++AGEW A K VK VG D QALDHPL TAI PH G L+P Sbjct 147 TYADSAEYYHYGPGLYREAGEWLAKKKVKMVGIDVQALDHPLGTAIGPH----GTGPLIP 202 Query 189 WAVREYEAQT-GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWR 247 EY T GR + +DFPDWEPCHRA+L+ GI G ENVGG+LDKVTGKR T AAFPWR Sbjct 203 HLEDEYREFTGGRGIKEDFPDWEPCHRALLNAGICGIENVGGELDKVTGKRCTLAAFPWR 262 Query 248 WVGGDGCIVRLVAIVDPTGSYRIETG 273 W GGDGC+VRLVA+VDP+G YRIE G Sbjct 263 WKGGDGCMVRLVAMVDPSGEYRIEQG 288 >gi|109898636|ref|YP_661891.1| putative cyclase [Pseudoalteromonas atlantica T6c] gi|109700917|gb|ABG40837.1| putative cyclase [Pseudoalteromonas atlantica T6c] Length=291 Score = 385 bits (988), Expect = 5e-105, Method: Compositional matrix adjust. Identities = 184/266 (70%), Positives = 210/266 (79%), Gaps = 5/266 (1%) Query 9 AAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPA 68 + ++ ++FYDLSH WG G P WPYFEDV+IERLHG ++S VLTQKITTVMHSGTHIDAPA Sbjct 27 SNDTGMQFYDLSHEWGLGQPCWPYFEDVKIERLHGHSRSGVLTQKITTVMHSGTHIDAPA 86 Query 69 HVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHH 128 HVVEGTPF+D++PL FFG GVVVSIPK KW ++TAEDL+N P IR GDIV++NTGWHH Sbjct 87 HVVEGTPFMDQMPLPRFFGAGVVVSIPKKKWEVITAEDLENVRPKIREGDIVIINTGWHH 146 Query 129 KYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLP 188 YADSAEYY Y PG ++AGEW A K VK VG D QALDHPL TAI PH G L+P Sbjct 147 TYADSAEYYHYGPGLYREAGEWLAKKKVKMVGIDVQALDHPLGTAIGPH----GTGPLIP 202 Query 189 WAVREYEAQT-GRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWR 247 EY T GR + +DFPDWEPCHRA+L+ GI G ENVGG+LDKVTGKR T AAFPWR Sbjct 203 HLEDEYREFTGGRGIKEDFPDWEPCHRALLNSGICGIENVGGELDKVTGKRCTIAAFPWR 262 Query 248 WVGGDGCIVRLVAIVDPTGSYRIETG 273 W GGDGC+VRLVA+VDP G YRIE G Sbjct 263 WKGGDGCMVRLVAMVDPKGEYRIEQG 288 >gi|11498799|ref|NP_070028.1| hypothetical protein AF1200 [Archaeoglobus fulgidus DSM 4304] gi|2649387|gb|AAB90047.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304] Length=278 Score = 321 bits (823), Expect = 6e-86, Method: Compositional matrix adjust. Identities = 155/251 (62%), Positives = 187/251 (75%), Gaps = 1/251 (0%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 +E YDLS+P+G+G P WPYF DV I+R H AKSRVL+Q ITT MH TH DAP HV EG Sbjct 26 VEVYDLSNPFGYGVPLWPYFNDVIIDRYHYHAKSRVLSQIITTTMHVSTHADAPIHVEEG 85 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 P +DE+P+ + G GVVVSIPK KW ++TAEDL+ A P I GDIV+VNTGWH ++DS Sbjct 86 FPSIDEVPIERYMGEGVVVSIPKKKWEVITAEDLEKADPPIEKGDIVIVNTGWHRYWSDS 145 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSP-AEAQGGLLPWAVR 192 +Y+ Y+PGF K+AGEWF K VKAVG DTQALDHPLAT A H P A+ + +LPW Sbjct 146 VKYFCYAPGFYKEAGEWFVKKKVKAVGIDTQALDHPLATREAWHHPGADERNSILPWLKE 205 Query 193 EYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGD 252 EY+ TGR V +DFP WEPCHR +L+ GI G+ENVGGD+DKVTG+R T P RWV GD Sbjct 206 EYKQLTGRDVSEDFPYWEPCHRLLLTHGIMGWENVGGDIDKVTGQRCTIIGLPIRWVKGD 265 Query 253 GCIVRLVAIVD 263 G IVRLVA+V+ Sbjct 266 GSIVRLVALVE 276 >gi|118592789|ref|ZP_01550178.1| hypothetical protein SIAM614_29031 [Stappia aggregata IAM 12614] gi|118434559|gb|EAV41211.1| hypothetical protein SIAM614_29031 [Stappia aggregata IAM 12614] Length=279 Score = 289 bits (740), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 153/264 (58%), Positives = 188/264 (72%), Gaps = 7/264 (2%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 +EFY+LSH +G P WPYF+DVQI+R H MAKS VL+Q ITT MH THIDAPAHVV+G Sbjct 20 VEFYNLSHRYGFQCPNWPYFQDVQIDRKHYMAKSGVLSQTITTTMHVTTHIDAPAHVVQG 79 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPD-IRPGDIVVVNTGWHHKYAD 132 TPF+DE+PL FFG+G+VVSIPK KW +T +DL+ A IR D++++NTGWH +Y D Sbjct 80 TPFIDEVPLPHFFGSGLVVSIPKKKWEQITGDDLEKACGHAIRKNDVLIINTGWHKQYED 139 Query 133 SAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVR 192 +Y+AY PG A +W KG+K VG DTQA DHPLATAI P + G +LP Sbjct 140 -GDYFAYCPGLVPSAADWIVEKGIKVVGHDTQANDHPLATAIGP----QRNGPILPHLEA 194 Query 193 EY-EAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGG 251 EY E GR +DFP+WEP H+ + S GI G ENVGGDLD+VTGKR TFA FPW W G Sbjct 195 EYKEWSGGRGWEEDFPEWEPVHQKLFSNGILGIENVGGDLDEVTGKRCTFAFFPWNWDRG 254 Query 252 DGCIVRLVAIVDPTGSYRIETGKA 275 DGCI+RLVA++D YRIE G++ Sbjct 255 DGCIIRLVAMIDKGQQYRIEAGES 278 >gi|339442508|ref|YP_004708513.1| hypothetical protein CXIVA_14450 [Clostridium sp. SY8519] gi|338901909|dbj|BAK47411.1| hypothetical protein CXIVA_14450 [Clostridium sp. SY8519] Length=305 Score = 233 bits (594), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 114/257 (45%), Positives = 155/257 (61%), Gaps = 9/257 (3%) Query 11 ESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTV-MHSGTHIDAPAH 69 + E DLS+P+G G P WP D I+R+ M L Q + MH+ TH D+P+H Sbjct 34 DGKFELVDLSNPFGRGNPLWPSNGDFHIDRVQHMPMHYRLLQTFNSFHMHNSTHADSPSH 93 Query 70 VVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPD----IRPGDIVVVNTG 125 V+ +PF E+P+ +FG V + IPKGKW +++ ED++NA I+ GD V++NTG Sbjct 94 VIPESPFTHELPIENYFGEAVCLDIPKGKWELISVEDIENAAKKVPGGIKEGDWVLLNTG 153 Query 126 WHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGG 185 H ++ ++ +Y+AYSPG + WF V+ VG D QA+DH L T A H P G Sbjct 154 THRRWGENDDYFAYSPGLSIEGAHWFVDHHVRGVGFDMQAIDHILYTYAAEHGP----GP 209 Query 186 LLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFP 245 +P AV EYE + G +DFP+WEPCH +LS + G EN+GGDLDK+T +R F AFP Sbjct 210 YVPRAVEEYEEEFGHPAKEDFPEWEPCHDILLSNNVMGIENLGGDLDKLTNQRFLFCAFP 269 Query 246 WRWVGGDGCIVRLVAIV 262 RW GDG IVR VA V Sbjct 270 LRWYMGDGTIVRAVAFV 286 >gi|87122102|ref|ZP_01077986.1| hypothetical protein MED121_04133 [Marinomonas sp. MED121] gi|86162649|gb|EAQ63930.1| hypothetical protein MED121_04133 [Marinomonas sp. MED121] Length=311 Score = 199 bits (505), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 112/287 (40%), Positives = 154/287 (54%), Gaps = 41/287 (14%) Query 18 DLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVE----- 72 DLSHP+G P WPYF+ +IE +HG++K+ VLTQK+ VMH GTH D+P HV+E Sbjct 8 DLSHPFGSNMPVWPYFKKPKIETMHGLSKAGVLTQKVDFVMHCGTHADSPRHVLEHEFDG 67 Query 73 -GTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNA------TPDIRPGDIVVVNTG 125 + E+ L ++G V + + +WG+++A DL +A T + G I+++ TG Sbjct 68 KRARYTHEMELDEYYGDAVCLDVKIHQWGLISAADLDDAVERSAVTHEELEGMIIIIRTG 127 Query 126 WHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGG 185 H K+ DS +Y+ Y G +AG WF VK VG D QALDHPL T++ + G Sbjct 128 MHLKWDDSKDYFHYCAGTGVEAGHWFVKHKVKTVGLDQQALDHPLHTSMGLNGTNMNLVG 187 Query 186 LLPWAVRE-------------YEAQT-----GRKVLDDF-----------PDWEPCHRAI 216 + E + +T G+ D+ WEPCH+ + Sbjct 188 RSSKPITEEYIEKFGEEAYAWFHKETFIKLHGQAAYDEMYGLIEEKAGCVGTWEPCHKLM 247 Query 217 LSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVD 263 L GI G+ENVGGDLDKV GKR FP RWV GDG +VRLVA +D Sbjct 248 LGNGITGWENVGGDLDKVVGKRFKIMGFPIRWVEGDGSMVRLVAEID 294 >gi|310657511|ref|YP_003935232.1| hypothetical protein CLOST_0197 [Clostridium sticklandii DSM 519] gi|308824289|emb|CBH20327.1| conserved protein of unknown function [Clostridium sticklandii] Length=312 Score = 198 bits (503), Expect = 9e-49, Method: Compositional matrix adjust. Identities = 114/288 (40%), Positives = 151/288 (53%), Gaps = 42/288 (14%) Query 18 DLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVE----- 72 DL+HP+ P WPYF +I+ +H +AKS VLTQKI VMH GTH DAP HV+E Sbjct 8 DLTHPFHADIPVWPYFAKPKIDTMHNLAKSGVLTQKIDVVMHCGTHADAPRHVMEYEFDG 67 Query 73 -GTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATP--DIRP----GDIVVVNTG 125 + E+PL A++G V + I +WG++TA+ L +A +I+P G ++ + TG Sbjct 68 KRARYTHEMPLDAYYGDAVCLDIKVDRWGLITADHLYDACKRANIKPEELEGMVICLRTG 127 Query 126 WHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHS---PAEA 182 H K+ D+ EYY YS G ++AGEWFA K V D QALDHPL T + + Sbjct 128 MHLKFDDTREYYHYSCGTGREAGEWFAKYKPKCVAMDMQALDHPLHTTMGKNGGYVGMNL 187 Query 183 QGGLLPWAVREYEAQTGRKVLDDFPD---------------------------WEPCHRA 215 G EY + G + +F WEPCH+ Sbjct 188 IGNSGKPITDEYIEKFGIEAYAEFNKDTFIDVFGKDKYMEAYGMLENHGLEGTWEPCHKL 247 Query 216 ILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVD 263 ++ GI G EN+GGDLDKV KR F AFP RW GDG +VR VA +D Sbjct 248 MMGNGIVGVENLGGDLDKVVNKRFKFMAFPIRWWLGDGSMVRCVAEID 295 >gi|339441306|ref|YP_004707311.1| hypothetical protein CXIVA_02420 [Clostridium sp. SY8519] gi|338900707|dbj|BAK46209.1| uncharacterized ACR protein [Clostridium sp. SY8519] Length=345 Score = 168 bits (425), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 110/310 (36%), Positives = 151/310 (49%), Gaps = 53/310 (17%) Query 13 TLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVE 72 + + DL+HP+G P WPYF+ I+ H MAK VLTQ I MH+GTH DAP HV+E Sbjct 3 NMVYVDLTHPFGAEIPRWPYFDKPVIDSKHSMAKGGVLTQYIGCTMHTGTHCDAPRHVME 62 Query 73 ------GTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNAT------PDIRPGD-- 118 + E+P+ A+ G V + I +WG++T + L +A PD G+ Sbjct 63 VEFDGKRARYTHEMPIDAYTGDAVALDIQIERWGLITGKHLDDACRRMGIDPDPAKGELE 122 Query 119 --IVVVNTGWHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAP 176 +V + TG + + D+ EYY YS G +AG+WF VK V D QALDHPL TA+ Sbjct 123 NKVVCLVTGMNQLFDDTKEYYHYSCGTGVEAGQWFVDHKVKCVAMDMQALDHPLHTAMGN 182 Query 177 HSPAE-----AQGGLLPWAVREYEAQTGRKVLDDFP------------------------ 207 + A G + +E + D F Sbjct 183 NGMTRMNLLGASGKPITEEYKELFGEEAYAEFDKFEYIRLHGQEAYDKKFGALEAIGCWG 242 Query 208 DWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVD---- 263 WEPCH+ +L GI G EN+GGD++KV GK+ F FP RW GDG + R VA +D Sbjct 243 TWEPCHKTMLGHGIVGVENLGGDIEKVKGKKFKFFCFPLRWYMGDGSMARCVAYIDEDDI 302 Query 264 ----PTGSYR 269 PT +Y+ Sbjct 303 NKDVPTRTYK 312 >gi|313902911|ref|ZP_07836307.1| cyclase family protein [Thermaerobacter subterraneus DSM 13965] gi|313466846|gb|EFR62364.1| cyclase family protein [Thermaerobacter subterraneus DSM 13965] Length=265 Score = 157 bits (396), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 91/263 (35%), Positives = 137/263 (53%), Gaps = 19/263 (7%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 +E DLSHPWG PA+ ++ ++ + A RV QKI T +H GTH+DAP H + G Sbjct 13 VELIDLSHPWGVNTPAFAGYDGPVVKWIKRPAFDRVGGQKIETTLHVGTHLDAPIHFITG 72 Query 74 TPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYA 131 + +PL FG GVVV I G + + T E + ++R GDI++++TG+HH Y Sbjct 73 GKDIASLPLDRLFGPGVVVDISDEVGDYDIYTPEHITRKV-EVRKGDILIIHTGYHHYYN 131 Query 132 -----DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGL 186 D Y+ PG ++ EW + ++ +G D + DHP+ T I L Sbjct 132 HGDRPDEERYFCKHPGPTREFAEWALSMELRWIGIDAGSADHPMNTVIR---------KL 182 Query 187 LPWAVREYEAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAF 244 P RE E + GR + + FPD ++ H + + ENVGGD+D+V +RV F Sbjct 183 RPDLAREAERKLGRPLDEIFPDHEFQLMHNFLFPHDLVHVENVGGDIDRVLNQRVWIGCF 242 Query 245 PWRWVGGDGCIVRLVAIVDPTGS 267 PW++ GG+ R+VA V G+ Sbjct 243 PWKFEGGEAAFCRVVAFVQKQGA 265 >gi|317122308|ref|YP_004102311.1| cyclase family protein [Thermaerobacter marianensis DSM 12885] gi|315592288|gb|ADU51584.1| cyclase family protein [Thermaerobacter marianensis DSM 12885] Length=275 Score = 153 bits (387), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 90/260 (35%), Positives = 135/260 (52%), Gaps = 19/260 (7%) Query 12 STLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVV 71 S +E DLSHPW PA+ ++ ++ + A RV QKI T +H GTH+DAP H + Sbjct 24 SHVELIDLSHPWSVHTPAFAGYDGPVVKWIKRPAFDRVGGQKIETTLHVGTHLDAPIHFI 83 Query 72 EGTPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHK 129 G + +PL FG GVVV I G + + T E + ++R GDI++++TG+HH Sbjct 84 TGGKDIASLPLDRLFGPGVVVDISDEVGDYDIYTPEHITRKV-EVRKGDILIIHTGYHHF 142 Query 130 YA-----DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQG 184 Y D Y+ PG ++ EW + ++ +G D + DHP+ T I Sbjct 143 YNHGDRPDEERYFCKHPGPTREFAEWALSMELRWIGVDAGSADHPMNTVIR--------- 193 Query 185 GLLPWAVREYEAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFA 242 L P RE E + GR + + FPD ++ H + + ENVGGD+D+V +RV Sbjct 194 KLRPDLAREAERKLGRPLDEIFPDHEFQLMHNFLFPHDLVHVENVGGDIDRVLNQRVWIG 253 Query 243 AFPWRWVGGDGCIVRLVAIV 262 FPW++ GG+ R+VA V Sbjct 254 CFPWKFEGGEAAFCRVVAFV 273 >gi|300855541|ref|YP_003780525.1| putative cyclase [Clostridium ljungdahlii DSM 13528] gi|300435656|gb|ADK15423.1| putative cyclase [Clostridium ljungdahlii DSM 13528] Length=263 Score = 145 bits (367), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 87/260 (34%), Positives = 131/260 (51%), Gaps = 17/260 (6%) Query 12 STLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVV 71 ++ YDL+ H P WP +E +QI+ ++ + Q +T H GTH+D H Sbjct 8 KNVQMYDLTQKISHLTPPWPTYEPLQIKFFKRLSSNGANGQVLTHSNHVGTHLDGSLHFC 67 Query 72 EGTPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHK 129 + IPL GVVV I +G+ T++D+ D+R GDI++++TG+H K Sbjct 68 THGRDISSIPLEELVAPGVVVDISDIAEDYGIYTSKDIMQRA-DVRKGDILIIHTGYH-K 125 Query 130 YA------DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQ 183 YA D PG K+ +W K +G D + DHP+ T I +P EA+ Sbjct 126 YAWDEPEADEERVMMRHPGPTKEFSKWCRKMEFKWLGVDCGSADHPMNTKIREWAPKEAK 185 Query 184 GGLLPWAVREYEAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDKVTGKRVTF 241 A + A+ G+ + D +PD ++ H + I EN+GGD+DKV GKR+ Sbjct 186 K-----AEKYLRAKYGKGITDFWPDEDYQLMHYDLFPYNIVHAENLGGDIDKVLGKRLVI 240 Query 242 AAFPWRWVGGDGCIVRLVAI 261 FPWR+VGG+ CI R+VA Sbjct 241 GCFPWRFVGGESCICRIVAF 260 >gi|307298666|ref|ZP_07578469.1| cyclase family protein [Thermotogales bacterium MesG1.Ag.4.2] gi|306915831|gb|EFN46215.1| cyclase family protein [Thermotogales bacterium MesG1.Ag.4.2] Length=263 Score = 144 bits (364), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 83/257 (33%), Positives = 131/257 (51%), Gaps = 17/257 (6%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 + Y+LS P H P WP +E +QI+ +A + Q +T H GTH+D H Sbjct 9 IRIYELSQPISHLTPPWPTYEPLQIKFFKRLAPNGANGQLLTHSNHVGTHLDGSLHFCTH 68 Query 74 TPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYA 131 + IPL+ GV+V + +G+ T++D++ +++ GDI+++NTG+H KYA Sbjct 69 GRDIASIPLNELVAPGVIVDLSDIAEDYGIYTSKDIEERV-EVKEGDILIINTGYH-KYA 126 Query 132 ------DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGG 185 D Y PG ++ EW K +K +G D + DHP+ T I P +A+ Sbjct 127 YDQPEADEVRYMIKHPGPTREFAEWCKMKKIKWIGVDCGSADHPMNTKIREWMPVQAKE- 185 Query 186 LLPWAVREYEAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAA 243 + G+ + + FPD ++ H + I ENVGG++DK+ KR+ Sbjct 186 ----CDHYMHEKYGKSLEEIFPDEDYQLMHVLLFPYDIIHAENVGGEIDKILDKRMVIGC 241 Query 244 FPWRWVGGDGCIVRLVA 260 FPWR+VGG+ CI R+VA Sbjct 242 FPWRFVGGESCISRIVA 258 >gi|269792029|ref|YP_003316933.1| cyclase family protein [Thermanaerovibrio acidaminovorans DSM 6589] gi|269099664|gb|ACZ18651.1| cyclase family protein [Thermanaerovibrio acidaminovorans DSM 6589] Length=267 Score = 142 bits (357), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 85/261 (33%), Positives = 132/261 (51%), Gaps = 16/261 (6%) Query 13 TLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVE 72 ++ YDL+ P H PAWP +E +Q++ +A + Q +T H GTH+D P H Sbjct 12 NIKVYDLTIPISHLTPAWPTYEPLQVKFFKRLAPNGANGQLLTHSNHVGTHLDGPLHFCT 71 Query 73 GTPFLDEIPLSAFF-GTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWH-- 127 + + L F G GVVV I +G+ T++D++ +I GDI+++NTG+H Sbjct 72 HGCDIASLELKDFLVGPGVVVDISDIAEDYGIYTSKDIEERA-EIHDGDILIINTGYHRY 130 Query 128 ---HKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQG 184 AD Y PG + +W + +K +G D + DHP+ T I P A+ Sbjct 131 GWDQPEADEVRYMVMHPGPTNEFAQWCKKRKIKWIGVDCGSADHPMNTKIREWMPYHAK- 189 Query 185 GLLPWAVREYEAQTGRKVLDDFP--DWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFA 242 A + + G+ + D FP D++ H + I E +GGD+D ++GKRVT Sbjct 190 ----MADKHLREKYGKGLDDFFPPEDYQLMHIDLFPHNIIHAECLGGDIDLLSGKRVTIG 245 Query 243 AFPWRWVGGDGCIVRLVAIVD 263 FPWR+ GG+ CI R+VA + Sbjct 246 CFPWRFEGGESCISRIVAFAE 266 >gi|289524300|ref|ZP_06441154.1| putative cyclase [Anaerobaculum hydrogeniformans ATCC BAA-1850] gi|289502472|gb|EFD23636.1| putative cyclase [Anaerobaculum hydrogeniformans ATCC BAA-1850] Length=268 Score = 140 bits (352), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 89/261 (35%), Positives = 132/261 (51%), Gaps = 18/261 (6%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 ++ YDLS P P WP +E +Q++ +A + Q +T H GTH+D P H Sbjct 14 VKIYDLSIPISQLTPPWPTYEPLQVKFFKRLAPNGANGQLLTHSNHVGTHLDGPLHFCTH 73 Query 74 TPFLDEIPLSAFF-GTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWH--- 127 + +PL F G GVVV + +G+ T++D++ D+ GDI+++NTG+H Sbjct 74 GDDIASLPLQGFLVGPGVVVDLSDIAEDFGVYTSKDIEERA-DVHEGDILIINTGYHRYG 132 Query 128 --HKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGG 185 AD Y PG K+ EW K +K +G D + DHP+ T I P A+ Sbjct 133 FDQPEADEVRYMVMHPGPTKEFAEWCKKKKIKWIGVDCGSADHPMNTKIREWMPQYAK-- 190 Query 186 LLPWAVREYEAQTGRKVLDD-FP--DWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFA 242 EY + K LD+ FP D++ H A+ I E +GGD+DK+ GKRV Sbjct 191 ----LADEYMRKKYNKTLDEMFPAEDYQIMHIALFPDNIIHAECLGGDIDKLLGKRVIVG 246 Query 243 AFPWRWVGGDGCIVRLVAIVD 263 FPW++ GG+ CI R+VA + Sbjct 247 CFPWKFQGGESCISRIVAFTE 267 >gi|312880791|ref|ZP_07740591.1| cyclase family protein [Aminomonas paucivorans DSM 12260] gi|310784082|gb|EFQ24480.1| cyclase family protein [Aminomonas paucivorans DSM 12260] Length=267 Score = 137 bits (345), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 89/274 (33%), Positives = 139/274 (51%), Gaps = 19/274 (6%) Query 1 MTFAWPLGAAESTLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHS 60 M+ W L + L+ YDLS P H PAWP +E +QI+ +A + Q +T H Sbjct 1 MSNNWEL-KNWNDLKVYDLSIPISHLTPAWPTYEPLQIKFFKRLAPNGANGQLLTHSNHV 59 Query 61 GTHIDAPAHVVEGTPFLDEIPLSAFF-GTGVVVSIPK--GKWGMVTAEDLQNATPDIRPG 117 GTH+D P H + + L + G GVVV + +G+ ++D+++ ++ G Sbjct 60 GTHLDGPLHFCTHGGDIASLELKNYLVGPGVVVDLSDMAEDYGIYGSKDIEDRA-EVHDG 118 Query 118 DIVVVNTGWHHKY------ADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLA 171 DI+++NTG+H KY AD Y PG + W + +K +G D + DHP+ Sbjct 119 DILIINTGYH-KYGWDQPEADEIRYMIKHPGPTLEFAHWCEKRKIKWLGVDCGSADHPMN 177 Query 172 TAIAPHSPAEAQGGLLPWAVREYEAQTGRKVLDDFP--DWEPCHRAILSQGIYGFENVGG 229 T I P A+ A + + G+ + D FP D++ H + I E +GG Sbjct 178 TKIREWMPQYAK-----LADAHLKGKYGKGLDDFFPPEDYQLMHIELFPHNIIHAECLGG 232 Query 230 DLDKVTGKRVTFAAFPWRWVGGDGCIVRLVAIVD 263 D+D ++GKRVT FPW++VGG+ CI R+VA + Sbjct 233 DIDLLSGKRVTIGCFPWKFVGGESCISRIVAFAE 266 >gi|221632605|ref|YP_002521826.1| putative polyketide cyclase [Thermomicrobium roseum DSM 5159] gi|221156178|gb|ACM05305.1| putative polyketide cyclase [Thermomicrobium roseum DSM 5159] Length=273 Score = 131 bits (330), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 79/266 (30%), Positives = 127/266 (48%), Gaps = 30/266 (11%) Query 18 DLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFL 77 DLS W P + +E ++ + +A R Q I++ +H GTH+DAP H + G + Sbjct 12 DLSQDWDIHTPGFALYEGPTVKWIKRVAFERAGGQWISSTLHVGTHLDAPLHFITGGQDI 71 Query 78 DEIPLSAFFGTGVVVSIPK---GKWGMVTAEDLQNATPD----IRPGDIVVVNTGWHHKY 130 IPL+ G +V + + G + + E + D I+PGDI+V++TG+HH Y Sbjct 72 AAIPLNKLVGWACIVDLTRYGIGDYDIYGPEHFEQWERDTGIRIQPGDILVIHTGYHHYY 131 Query 131 A------------DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHS 178 D Y+ PG + EW + + + D + DHP T I Sbjct 132 PSDWATDPALRQPDETRYFIKHPGPTRAFAEWVLRRQISWLAVDCASADHPFNTVIR--- 188 Query 179 PAEAQGGLLPWAVREYEAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDKVTG 236 + + L+P E+EA+ G+ + + PD ++ H A+ G+ EN GG++DKV Sbjct 189 --KIRADLVP----EFEAKHGKSISELLPDSDYQVMHFALFPHGVIHIENAGGEIDKVLN 242 Query 237 KRVTFAAFPWRWVGGDGCIVRLVAIV 262 +R+ FPWR+ GG+ R VA V Sbjct 243 RRIMVGCFPWRFKGGEAAFCRFVAFV 268 >gi|221632604|ref|YP_002521825.1| putative polyketide cyclase [Thermomicrobium roseum DSM 5159] gi|221157014|gb|ACM06141.1| putative polyketide cyclase [Thermomicrobium roseum DSM 5159] Length=264 Score = 131 bits (329), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 82/265 (31%), Positives = 133/265 (51%), Gaps = 19/265 (7%) Query 13 TLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVE 72 +++ YDLS P WP++ +++ + A+ V Q I T H GTH+DAP H + Sbjct 3 SVKLYDLSQPLNQEVSFWPFYPPFEVKYIKRKAEHGVNAQYIMTSNHMGTHLDAPRHFIT 62 Query 73 GTPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKY 130 +D+IPL +G GV+V + + + T E ++ ++R GDI+ ++TGW H+Y Sbjct 63 NGKTIDQIPLEWLYGPGVIVDLSDVLDELDIFTPEMIEQRV-EVREGDILFIHTGW-HRY 120 Query 131 A------DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQG 184 A D +Y PG +W AK +K G D + DHP+ I +G Sbjct 121 AQFGETPDEEKYLLRHPGPHPSIVDWLIAKKIKIWGVDMVSTDHPMNLPIGRFL---GRG 177 Query 185 GLLPWA-VREY-EAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDK--VTGKR 238 GL W VR E + G K+ + FP+ ++ H A+ EN+GG++ + + +R Sbjct 178 GLEQWKRVRAICERKFGEKLTELFPEEHYQLTHNALFPHDCIHVENLGGEIGRRELHNRR 237 Query 239 VTFAAFPWRWVGGDGCIVRLVAIVD 263 +T FPW + GG+ R+VA V+ Sbjct 238 LTLGVFPWLFKGGEAAFCRVVAFVE 262 >gi|338813078|ref|ZP_08625218.1| putative cyclase [Acetonema longum DSM 6540] gi|337274956|gb|EGO63453.1| putative cyclase [Acetonema longum DSM 6540] Length=261 Score = 129 bits (325), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 81/255 (32%), Positives = 123/255 (49%), Gaps = 17/255 (6%) Query 16 FYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTP 75 YDL+ H P WP +E +QI+ ++ + Q ITT H GTH+D H Sbjct 10 MYDLTQKLSHLTPPWPTYEPLQIKFFKRLSSNGANGQVITTSNHVGTHLDGSLHFCTHGR 69 Query 76 FLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNT-----GWHH 128 + IPL+ G GVVV + +G+ T++D+ + ++R GDI++++T GW Sbjct 70 DIASIPLNDLIGPGVVVDLSDICEDYGVYTSKDITDRV-EVRKGDILLIHTGYMKYGWDQ 128 Query 129 KYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLP 188 AD Y PG ++ +W +K +G D + DHP+ T I P +A Sbjct 129 PEADEVRYMVKHPGPTREFSQWCRKMEIKWLGVDAGSADHPMNTKIREWCPKQAA----- 183 Query 189 WAVREYEAQTGRKVLDDF--PD-WEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFP 245 Y + K LD+ PD ++ H + I ENVGG+L KV KR+ +P Sbjct 184 -ECDSYMQKKFGKSLDEMFPPDHYQLMHVDLFPYDIIHAENVGGELQKVLNKRLIIGCYP 242 Query 246 WRWVGGDGCIVRLVA 260 WR+ GG+ I R+VA Sbjct 243 WRFEGGESSICRIVA 257 >gi|150388525|ref|YP_001318574.1| cyclase family protein [Alkaliphilus metalliredigens QYMF] gi|149948387|gb|ABR46915.1| cyclase family protein [Alkaliphilus metalliredigens QYMF] Length=267 Score = 127 bits (318), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 80/258 (32%), Positives = 124/258 (49%), Gaps = 22/258 (8%) Query 17 YDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPF 76 YDL+ H P WP +E +QI+ ++ Q ITT H GTH+D P H Sbjct 13 YDLTQNLSHLTPPWPTYEPLQIKFFKRLSPHGANGQLITTSNHVGTHLDGPLHFDTAGRD 72 Query 77 LDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKY---- 130 + +PL G GVVV + +G+ T +D+ + +++ GDI+++NTG+ HKY Sbjct 73 IASLPLDKLVGPGVVVDLSDIAEDYGIYTPKDITDRV-EVKKGDILIINTGY-HKYGWDQ 130 Query 131 --ADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLP 188 AD Y PG +W +K +G D + DHP+ T I P EA Sbjct 131 PEADERRYMLRHPGPSMDFIDWIKEMEIKWIGVDCGSADHPMNTKIREWEPGEA------ 184 Query 189 WAVREYEAQTGRKVLDDFPDWEPCHRAILSQ------GIYGFENVGGDLDKVTGKRVTFA 242 Y + K L++ W ++A+ ++ I ENVGG L++V +R+ Sbjct 185 LQADAYLQEKYGKALEEIYSWPQTYQAMHTKVFPKPYEIIHAENVGGQLNEVLNRRLIIG 244 Query 243 AFPWRWVGGDGCIVRLVA 260 FPW++VGG+ I R++A Sbjct 245 CFPWKFVGGESSICRILA 262 >gi|284046452|ref|YP_003396792.1| cyclase family protein [Conexibacter woesei DSM 14684] gi|283950673|gb|ADB53417.1| cyclase family protein [Conexibacter woesei DSM 14684] Length=264 Score = 126 bits (317), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 76/270 (29%), Positives = 128/270 (48%), Gaps = 53/270 (19%) Query 13 TLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLT-----------QKITTVMHSG 61 T E YDLS P+ P++ ++E+ + + + T ++ + H+G Sbjct 22 TREVYDLSLPFRRDMPSYYFYENRYQPPMFTVFSHKEGTPLGPETKDGYVTHVSFLTHTG 81 Query 62 THIDAPAHVVEGTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATP----DIRPG 117 TH+DAP H + +L E+P + G G ++S+PK + +TAEDL+ A D+RPG Sbjct 82 THVDAPRHFRDDGQYLHEVPADRWLGEGPILSVPKEEMEPITAEDLERACAESGLDVRPG 141 Query 118 DIVVVNTGWHHKYA-------DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPL 170 DIV +NTGWH ++ + EY +PG +++ EW AKG+ V D+ A+D Sbjct 142 DIVGINTGWHRRFCGPGEDRDQAIEYMERNPGLSRESAEWLVAKGIVTVMIDSPAID--- 198 Query 171 ATAIAPHSPAEAQGGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGD 230 +P+ +++ H A+ ++ + E +GG Sbjct 199 ------------CARFMPYGDSSFQS----------------HYALFAENVPAVEGLGGQ 230 Query 231 LDKVTGKRVTFAAFPWRWVGGDGCIVRLVA 260 LD+VTGKR + P R+ GD +R++A Sbjct 231 LDEVTGKRCLISCAPVRYENGDAFPLRVLA 260 >gi|167770182|ref|ZP_02442235.1| hypothetical protein ANACOL_01525 [Anaerotruncus colihominis DSM 17241] gi|167667504|gb|EDS11634.1| hypothetical protein ANACOL_01525 [Anaerotruncus colihominis DSM 17241] Length=266 Score = 123 bits (309), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 82/266 (31%), Positives = 129/266 (49%), Gaps = 24/266 (9%) Query 12 STLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVV 71 S ++ YDLS P G P WP +E +Q++ +A + Q +T H GTH+D P H Sbjct 5 SDIKMYDLSIPIGILTPPWPTYEPMQMKFFKRLAPNGANGQLVTHSNHVGTHLDGPLHFD 64 Query 72 EGTPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHK 129 + + L+ GVVV I +G+ T +DL + +IR GDI+++NTG+ HK Sbjct 65 TAGRDIASLELTKLCAPGVVVDISDMGQDFGIYTPKDLMDRA-EIRKGDILIINTGY-HK 122 Query 130 Y------ADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQ 183 Y AD Y PG +W +K +G D + DHP+ T I P EA+ Sbjct 123 YGFDQPTADERRYMLRHPGPSMDFVQWIRDMEIKWIGVDCGSADHPMNTKIRDWEPMEAE 182 Query 184 GGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQ-------GIYGFENVGGDLDKVTG 236 A + + K L++ +W ++A+ Q I+ E +GG++DK++ Sbjct 183 ------ACDKIFMERYGKHLNEIYEWPKNYQAMHIQLFCQPYEAIHA-ECLGGEIDKLSN 235 Query 237 KRVTFAAFPWRWVGGDGCIVRLVAIV 262 +R FPW++ G+ CI R+VA Sbjct 236 QRCVIGCFPWKFTEGESCISRIVAFT 261 >gi|325972419|ref|YP_004248610.1| cyclase family protein [Spirochaeta sp. Buddy] gi|324027657|gb|ADY14416.1| cyclase family protein [Spirochaeta sp. Buddy] Length=291 Score = 119 bits (299), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 77/272 (29%), Positives = 131/272 (49%), Gaps = 17/272 (6%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 ++ DL+ P G G P WP + +Q++ +A + Q +T H GTH+D H Sbjct 1 MKVIDLTIPLGVGTPPWPTYIPLQVQYFKRLAPNGANGQVVTHSNHVGTHLDGEIHFYTP 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHK-- 129 + ++ + G +V + G + + T++ ++ +++ GDI++++TG+HH Sbjct 61 GKDIAQLDMDFLVHEGAIVDLSDVCGDYDVYTSKMVEERV-EVKEGDILLIHTGYHHYGW 119 Query 130 ---YADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGL 186 D Y PG D++ EW K ++ +G D + DHP+ T I P EA+ Sbjct 120 DQPTGDEIRYMIKHPGPDREFAEWAKKKKLRWIGVDCGSADHPMNTKIRDWMPKEAKQ-- 177 Query 187 LPWAVREYEAQTGRKVLDDF---PDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAA 243 ++ + G K LD+F ++ H + + GI E VGGDLD + +R Sbjct 178 ---CDAHFKEKYG-KPLDEFFSEDKYQLMHIEMFNHGIIHAECVGGDLDLLLNQRAVIGC 233 Query 244 FPWRWVGGDGCIVRLVAIVDPTGSYRIETGKA 275 +PWR+V G+ I R+VA VD R+ KA Sbjct 234 YPWRFVDGESSIARIVAHVDDDRYERLMAKKA 265 >gi|345004382|ref|YP_004807235.1| cyclase family protein [halophilic archaeon DL31] gi|344320008|gb|AEN04862.1| cyclase family protein [halophilic archaeon DL31] Length=254 Score = 119 bits (298), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 71/259 (28%), Positives = 128/259 (50%), Gaps = 21/259 (8%) Query 15 EFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGT 74 E +DL+ PW PAWP +++ ++ + +V QKI + H+GTH+D H + Sbjct 6 EMHDLTQPWCGDTPAWPTYDNPKVWYEKSLDTEKVNGQKIEFMNHTGTHLDGEKHFIGHG 65 Query 75 PFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTG-----WH 127 ++ +PL G V+ I G + + T+E +++ D+R GDI+ ++TG WH Sbjct 66 RDIESMPLDELVGDAVIADISDKVGDYDVFTSEMIEDVV-DVREGDILYIHTGYQKYAWH 124 Query 128 HKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATA---IAPHSPAEAQG 184 +AD +++ PG +++ +W KG+ + D + DHP+ T + P + AEA+ Sbjct 125 TDHADPHKFFIKHPGPNQEFADWCREKGLNYLIVDCGSADHPMNTVVRDVRPDAAAEARE 184 Query 185 GLLPWAVREYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAF 244 L + E + G +++ H + +GI EN +++ +RV F Sbjct 185 ALGVDDLDEIFPEEGYQLM---------HTELFPEGIIHVENAICP-EELLNERVQIGTF 234 Query 245 PWRWVGGDGCIVRLVAIVD 263 PWR+ GG+ + R VA + Sbjct 235 PWRFRGGESSVCRCVAFTE 253 >gi|110667888|ref|YP_657699.1| cyclase [Haloquadratum walsbyi DSM 16790] gi|109625635|emb|CAJ52066.1| probable cyclase [Haloquadratum walsbyi DSM 16790] Length=252 Score = 119 bits (297), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 75/256 (30%), Positives = 123/256 (49%), Gaps = 19/256 (7%) Query 15 EFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGT 74 E YDL+ PW PAWP +++ +I + +V QKI + H+GTH+D H + Sbjct 6 EMYDLTQPWSQETPAWPTYDNPKIWYEKSLDTEKVNGQKIEFMNHTGTHLDGEKHFIAHG 65 Query 75 PFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTG-----WH 127 + ++ L+ G GV+ I G + + T+E ++ A D+R GDI+ ++TG WH Sbjct 66 RDIADMSLNELVGDGVIADISDQVGDYDIYTSEMIEQAA-DVRKGDILFIHTGYQDHAWH 124 Query 128 HKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLL 187 + AD +++ PG + + EW + + D + DHP+ T I P A+ Sbjct 125 REEADPHKFFCKHPGPNAEFAEWCKEMEINYLILDCGSADHPMNTVIRDIRPELARE--- 181 Query 188 PWAVREYEAQTGRKVLDDFP--DWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFP 245 A +E +V FP ++ H + +GI EN ++ G+RV FP Sbjct 182 --AAEHFEVDDLDEV---FPPEGYQLMHTELFPEGIVHVENAQVPT-ELLGERVQIGTFP 235 Query 246 WRWVGGDGCIVRLVAI 261 WR+ GG+ + R VA Sbjct 236 WRFRGGESSVSRCVAF 251 >gi|339728827|emb|CCC40003.1| cyclase family protein [Haloquadratum walsbyi C23] Length=252 Score = 118 bits (295), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 74/256 (29%), Positives = 123/256 (49%), Gaps = 19/256 (7%) Query 15 EFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGT 74 E YDL+ PW PAWP +++ +I + +V QKI + H+GTH+D H + Sbjct 6 EMYDLTQPWSQETPAWPTYDNPKIWYEKSLDTEKVNGQKIEFMNHTGTHLDGEKHFIAHG 65 Query 75 PFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTG-----WH 127 + ++ L+ G GV+ I G + + T+E ++ A D+R GDI+ ++TG WH Sbjct 66 RDIADMSLNELVGDGVIADISDQVGDYDIYTSEMIEQAA-DVRKGDILFIHTGYQDHAWH 124 Query 128 HKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLL 187 + AD +++ PG + + EW + + D + DHP+ T I P A+ Sbjct 125 REEADPHKFFCKHPGPNAEFAEWCKEMEINYLILDCGSADHPMNTVIRDIRPELARE--- 181 Query 188 PWAVREYEAQTGRKVLDDFP--DWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFP 245 A +E ++ FP ++ H + +GI EN ++ G+RV FP Sbjct 182 --AAEHFEVDDLDEI---FPPEGYQLMHTELFPEGIVHVENAQVPT-ELLGERVQIGTFP 235 Query 246 WRWVGGDGCIVRLVAI 261 WR+ GG+ + R VA Sbjct 236 WRFRGGESSVSRCVAF 251 >gi|158319910|ref|YP_001512417.1| cyclase family protein [Alkaliphilus oremlandii OhILAs] gi|158140109|gb|ABW18421.1| cyclase family protein [Alkaliphilus oremlandii OhILAs] Length=264 Score = 117 bits (292), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 75/264 (29%), Positives = 122/264 (47%), Gaps = 22/264 (8%) Query 12 STLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVV 71 + ++ YDL+ H P WP +E +Q++ ++ + Q IT H GTH+D P H Sbjct 5 NNVKMYDLTQNTSHLTPPWPTYEPLQVKFFKRLSPNGANGQVITVSNHVGTHLDGPLHFD 64 Query 72 EGTPFLDEIPLSAFFGTGVVVSIP--KGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHK 129 + + L G GVVV + + + T +D+ + +++ GDI+++NTG+ HK Sbjct 65 TAGRDIASLELEKLVGPGVVVDLSDISEDFSIYTPQDIMDRV-EVKKGDILIINTGY-HK 122 Query 130 Y------ADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQ 183 Y AD Y PG +W ++ +G D + DHP+ T I P EA+ Sbjct 123 YGWDQPEADERRYMLRHPGPSLDFMDWVKEMEIRWIGVDCGSADHPMNTKIRDWEPGEAK 182 Query 184 GGLLPWAVREYEAQTGRKVLDDFPDWEPCHRAI------LSQGIYGFENVGGDLDKVTGK 237 Y + K L++ W ++A+ I EN+GG +D+V K Sbjct 183 ------RCDAYMREKYGKGLEEMYPWPDVYQAMHIHVFPKPHEIIHAENLGGQIDEVLNK 236 Query 238 RVTFAAFPWRWVGGDGCIVRLVAI 261 RV FPW++ GG+ R+VA Sbjct 237 RVIVGCFPWKFQGGESAFCRIVAF 260 >gi|315425928|dbj|BAJ47578.1| cyclase family protein [Candidatus Caldiarchaeum subterraneum] gi|343484722|dbj|BAJ50376.1| cyclase family protein [Candidatus Caldiarchaeum subterraneum] Length=288 Score = 117 bits (292), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 77/262 (30%), Positives = 125/262 (48%), Gaps = 23/262 (8%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 ++ YDLS P AP + ++ + + +++ V I +H GTH D H + G Sbjct 32 VKIYDLSQPTSTKAPPFMWYPPFKATWIKRLSEHNVNAMYIEGPLHHGTHFDGQLHFMTG 91 Query 74 TPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATP----DIRPGDIVVVNTG-- 125 + I ++ F G GVVV I + G + + T E ++ A +IRP DI+++ TG Sbjct 92 GKDIASIDINYFIGEGVVVDISRKVGDYDIYTPETIEGAAKEAGLEIRPDDILIIYTGYS 151 Query 126 ---WHHKYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEA 182 W + D Y PG D + +W K ++ +G D + DHPL T I P Sbjct 152 RYAWCGQEPDEVRYICKHPGPDVRFAKWCIEKKIRWLGVDAASQDHPLNTIIRRARPD-- 209 Query 183 QGGLLPWAVREYEAQTGRKVLDDFP---DWEPCHRAILSQGIYGFENVGGDLDKVTGKRV 239 V E E + G+K+ + P +++ H + + I EN+GGD+DKV KR Sbjct 210 -------LVAEAEKKWGKKIDELMPWPENYQVMHTMLFPKMILHAENLGGDIDKVANKRC 262 Query 240 TFAAFPWRWVGGDGCIVRLVAI 261 A P+++ GG+ R++AI Sbjct 263 LIMAPPFKFEGGESAYCRVIAI 284 >gi|320159994|ref|YP_004173218.1| hypothetical protein ANT_05840 [Anaerolinea thermophila UNI-1] gi|319993847|dbj|BAJ62618.1| hypothetical protein ANT_05840 [Anaerolinea thermophila UNI-1] Length=293 Score = 115 bits (289), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 73/259 (29%), Positives = 125/259 (49%), Gaps = 15/259 (5%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 ++ DL+ P G G PAWP +E +Q++ +A + Q +T H GTH+D H Sbjct 1 MKLIDLTIPLGIGTPAWPTYEPLQVKYFKRLAPNGANGQLLTHSNHLGTHLDGEIHFYTP 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTGWHH--- 128 + + + +V + G + + T++ ++ +++ GDI+V++TG+HH Sbjct 61 GKDMASLTMDYLVHEAAIVDLSDVCGDYDVYTSKMIEERV-EVKEGDILVIHTGYHHFGW 119 Query 129 --KYADSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGL 186 AD Y PG D++ EW K ++ + D + DHP+ T I P +A+ Sbjct 120 DMPTADEVRYMVKHPGPDREFAEWAKKKKLRWIAVDCGSADHPMNTIIRTWMPRQAKE-- 177 Query 187 LPWAVREYEAQTGRKVLDDFPD--WEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAF 244 A ++ + G + + F D ++ H + I E GG++D + +RVT F Sbjct 178 ---AEYVFKKKYGMSLEEFFSDDKYQLMHIEMFPHEIIHAECFGGEIDLLLNQRVTVGFF 234 Query 245 PWRWVGGDGCIVRLVAIVD 263 PWR+V G+ I R VA VD Sbjct 235 PWRFVDGEASIGRAVAFVD 253 >gi|218961867|ref|YP_001741642.1| putative cyclase [Candidatus Cloacamonas acidaminovorans] gi|167730524|emb|CAO81436.1| putative cyclase [Candidatus Cloacamonas acidaminovorans] Length=291 Score = 110 bits (275), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/267 (30%), Positives = 126/267 (48%), Gaps = 28/267 (10%) Query 12 STLEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSR----VLTQKITTVMHSGTHIDAP 67 +L+ YDL+ P P WP + + I+ +A + Q ITT H GTHID Sbjct 32 QSLKMYDLTQPLSIHTPPWPSYMPLGIQYFKRIAGAHSGQGANGQIITTSNHVGTHIDGE 91 Query 68 AHVVEGTPFLDEIPLSAFFGTGVVVSIPK--GKWGMVTAEDLQNATPDIRPGDIVVVNTG 125 H + ++P+ + G GVVV I + + + E L +I+ GDI+++NTG Sbjct 92 IHFFASGRSIGQVPMEEWIGPGVVVDISDSVNDYDLYSPELLMQKA-EIKKGDILIINTG 150 Query 126 WHHKYA------DSAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIA---P 176 + H+YA D Y+ PG D W +K +G D + DHP+ T I P Sbjct 151 Y-HRYAWDQPESDELRYFVKHPGPDPSFHTWALDMHLKWIGVDCGSADHPMNTIIRNWHP 209 Query 177 HSPAEAQGGLLPWAVREYEAQTGRKVLDDFPD---WEPCHRAILSQGIYGFENVGGDLDK 233 S EA+ L+ A+ G+ + FP ++ H + + + EN+GGD+DK Sbjct 210 GSFNEAEQKLI--------AKYGKTWDEMFPPEEYYQVMHLKLFPKKLVHAENLGGDIDK 261 Query 234 VTGKRVTFAAFPWRWVGGDGCIVRLVA 260 ++ KRV FP R + + + R++A Sbjct 262 ISNKRVWIGLFPLRGIELESSMCRIMA 288 >gi|78187925|ref|YP_375968.1| hypothetical protein Plut_2083 [Chlorobium luteolum DSM 273] gi|78167827|gb|ABB24925.1| Kynurenine formamidase [Chlorobium luteolum DSM 273] Length=217 Score = 101 bits (252), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 67/244 (28%), Positives = 103/244 (43%), Gaps = 38/244 (15%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 + +DLSH G P WP ++ G L ++ + H+GTH+D P H++ Sbjct 1 MRIHDLSHSIAEGMPLWPASPVTRVRDAAGYGTEGYLEREYSFSSHAGTHVDLPLHMLPE 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 LD PL AF G G V+ G+VTA + P D ++++TGW ++ S Sbjct 61 GRSLDACPLEAFAGRGFVLDAAPENGGVVTATVIAAGAPPEGSCDFLLIHTGWSSRWG-S 119 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 Y+ P ++A +KG+K +G D+ ++D PL Sbjct 120 PSYFEACPYLQEEAALLLVSKGLKGIGIDSPSIDPPLG---------------------- 157 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 D P HR +L G+ EN+ G L + GKR F+AFP + G + Sbjct 158 --------------DAYPSHRILLGHGLVVVENLTG-LFPLIGKRFLFSAFPLKIAGAEA 202 Query 254 CIVR 257 VR Sbjct 203 SPVR 206 >gi|331696441|ref|YP_004332680.1| cyclase family protein [Pseudonocardia dioxanivorans CB1190] gi|326951130|gb|AEA24827.1| cyclase family protein [Pseudonocardia dioxanivorans CB1190] Length=224 Score = 100 bits (250), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 76/258 (30%), Positives = 110/258 (43%), Gaps = 36/258 (13%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLT-QKITTVMHSGTHIDAPAHVVE 72 + D+SH G P P +V+ ++ +A L IT +H GTHIDAPAH V+ Sbjct 1 MALVDVSHQLWPGMPKIPILPEVERHQVARIADGAPLNISAITLALHVGTHIDAPAHAVD 60 Query 73 GTPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYAD 132 G +DE+P+ F GTGVV + + +T +D+ P R G+ ++V TGW ++ Sbjct 61 GAKTIDELPIERFAGTGVVAKVDRKPGEEITVDDVLAGGPAPRRGEFLLVATGWSERFL- 119 Query 133 SAEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVR 192 + YA P W +GV VG D I P P +G + Sbjct 120 -SPDYADHPSLSPDLAAWCVEQGVPFVGVDM----------ITPDLPVHRRGEGFDY--- 165 Query 193 EYEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGD 252 P HR +L + EN+ DL+ + G+RV A+P GGD Sbjct 166 ------------------PVHRTLLGAEVLIAENL-TDLEGLGGRRVHVHAYPLAIRGGD 206 Query 253 GCIVRLVAIVD-PTGSYR 269 R+V D P G R Sbjct 207 AGPARVVVDTDLPDGETR 224 >gi|20808973|ref|NP_624144.1| hypothetical protein TTE2628 [Thermoanaerobacter tengcongensis MB4] gi|20517639|gb|AAM25748.1| uncharacterized ACR, predicted metal-dependent hydrolases [Thermoanaerobacter tengcongensis MB4] Length=210 Score = 97.8 bits (242), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 72/250 (29%), Positives = 112/250 (45%), Gaps = 40/250 (16%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 + DLSH G P +P ++++ERL + K ++ V+H GTH DAPAH +E Sbjct 1 MRMIDLSHFIEEGMPQYPGQPEIKVERLVEVEKDGYQLTELKYVVHLGTHCDAPAHFIEK 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 ++++P+ + G V+V +P ++ E L+ D++ GDIV+ TG KY Sbjct 61 GDTIEKLPVDFYSGEAVIVDVPHLPDRLMRPELLEGV--DLKEGDIVIFRTGM-SKYWRE 117 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 Y P ++ + K VKA+G DT I+P P E + Sbjct 118 EAYIKEFPYLTEELAHFLVDKKVKAIGLDT----------ISP-DPVETE---------- 156 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 DF P H +L + EN+ +L+ + KR F A P + G DG Sbjct 157 -----------DF----PVHHVLLGNKVGIIENL-TNLEAIDKKRFLFIALPLKIKGSDG 200 Query 254 CIVRLVAIVD 263 VR VAI++ Sbjct 201 SPVRAVAILE 210 >gi|193213662|ref|YP_001999615.1| cyclase family protein [Chlorobaculum parvum NCIB 8327] gi|193087139|gb|ACF12415.1| cyclase family protein [Chlorobaculum parvum NCIB 8327] Length=217 Score = 97.8 bits (242), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 63/249 (26%), Positives = 102/249 (41%), Gaps = 38/249 (15%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 + DLSHP P WP + L + + + + H+GTH+DAPAH+ EG Sbjct 1 MRIVDLSHPISPAMPVWPGTPAPEFSDLCTVGRDGFGERWMQLSSHTGTHLDAPAHLFEG 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 LD + + F G G ++ + G+V+ + L+ P I D ++++ GW ++ + Sbjct 61 AASLDRMSVERFIGKGALLDLRGASSGLVSLDQLRVIQPSIEKADFLLLHVGW-SRFWGT 119 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 AEY P +A W A G+K VG D + D P + A+ Sbjct 120 AEYDRNYPVLSSEAATWLAGLGLKGVGIDAPSFDDPDSEAL------------------- 160 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 P HR +L G+ EN+ LD++ + P G + Sbjct 161 -----------------PIHRCLLGSGLLLIENLTA-LDQLGDSDFLLSVLPLPISGAEA 202 Query 254 CIVRLVAIV 262 VR VA++ Sbjct 203 SPVRAVAVI 211 >gi|325291131|ref|YP_004267312.1| cyclase family protein [Syntrophobotulus glycolicus DSM 8271] gi|324966532|gb|ADY57311.1| cyclase family protein [Syntrophobotulus glycolicus DSM 8271] Length=209 Score = 97.4 bits (241), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 65/248 (27%), Positives = 108/248 (44%), Gaps = 40/248 (16%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 +E DLSHP P +P E +IE + M ++ H+GTH+D P HV + Sbjct 1 MEVVDLSHPIREDMPVFPGEEQPKIEIVADMEHCGYHEKRFLLNSHTGTHLDVPKHVFQD 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 L++ P+ + G +++++ G + E+L +R D ++VNTGW + S Sbjct 61 GYSLEKYPVKKYIGQAIMITLIDS--GRIEIEELAPYENALRDCDFMLVNTGWSRHWG-S 117 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 A+YY P F ++A +W ++ +K +G D+ ++D + GL Sbjct 118 AQYYGDPPYFSREAADWLSSFELKGIGIDSPSVDQ------------MSDQGL------- 158 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 P HRA+L + I EN+ + D++ T P G D Sbjct 159 -----------------PVHRALLEKEIVIIENM-TNFDQLKKPVFTLYCLPLNIEGADA 200 Query 254 CIVRLVAI 261 C VR VA+ Sbjct 201 CPVRAVAV 208 >gi|254478157|ref|ZP_05091539.1| Putative cyclase superfamily protein [Carboxydibrachium pacificum DSM 12653] gi|214035886|gb|EEB76578.1| Putative cyclase superfamily protein [Carboxydibrachium pacificum DSM 12653] Length=208 Score = 96.7 bits (239), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 72/246 (30%), Positives = 111/246 (46%), Gaps = 40/246 (16%) Query 18 DLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEGTPFL 77 DLSH G P +P ++++ERL + K ++ V+H GTH DAPAH +E + Sbjct 3 DLSHFIEEGMPQYPGQPEIKVERLAEVEKDGYQLTELKDVVHLGTHCDAPAHFIEKGDTI 62 Query 78 DEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADSAEYY 137 +++P+ + G V+V +P ++ E L+ D++ GDIV+ TG KY Y Sbjct 63 EKLPVDFYSGEAVIVDVPHLPDRLMRPELLEGI--DLKVGDIVIFRTGM-SKYWREEAYI 119 Query 138 AYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVREYEAQ 197 P ++ + K VKA+G DT I+P P E + Sbjct 120 KEFPYLTEELAHFLVDKKVKAIGLDT----------ISP-DPVETE-------------- 154 Query 198 TGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDGCIVR 257 DF P H +L + EN+ +L+ + KR F A P + G DG VR Sbjct 155 -------DF----PVHHILLGNKVGIIENL-TNLEAIDKKRFLFIALPLKIKGSDGSPVR 202 Query 258 LVAIVD 263 VAI++ Sbjct 203 AVAILE 208 >gi|310780252|ref|YP_003968584.1| cyclase family protein [Ilyobacter polytropus DSM 2926] gi|309749575|gb|ADO84236.1| cyclase family protein [Ilyobacter polytropus DSM 2926] Length=211 Score = 95.1 bits (235), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/250 (28%), Positives = 106/250 (43%), Gaps = 40/250 (16%) Query 14 LEFYDLSHPWGHGAPAWPYFEDVQIERLHGMAKSRVLTQKITTVMHSGTHIDAPAHVVEG 73 ++ DL+H P +P E + E + + K +KIT H+GTH+DAP H++ Sbjct 1 MKIVDLTHEIRENMPVFPGSECPKFESIGILEKDGFEEKKITIYSHTGTHMDAPKHIIPY 60 Query 74 TPFLDEIPLSAFFGTGVVVSIPKGKWGMVTAEDLQNATPDIRPGDIVVVNTGWHHKYADS 133 LDE F G GVVV +G+ ++ + L I D +++NTGW + Sbjct 61 GKGLDEFSADKFLGKGVVVD-ARGE-SSISLDLLIEYEEKIEKSDFILINTGWDRNWG-K 117 Query 134 AEYYAYSPGFDKKAGEWFAAKGVKAVGTDTQALDHPLATAIAPHSPAEAQGGLLPWAVRE 193 YY P KKA +W ++K +K +G D ++D V Sbjct 118 ENYYNGFPCMTKKAAQWLSSKKIKGLGIDAISVD----------------------PVNS 155 Query 194 YEAQTGRKVLDDFPDWEPCHRAILSQGIYGFENVGGDLDKVTGKRVTFAAFPWRWVGGDG 253 YE H L + I EN+ +K+ GK+ F+A P + DG Sbjct 156 YELVN--------------HNIFLKKEIVIIENLKIP-EKLHGKKFLFSALPLKTENSDG 200 Query 254 CIVRLVAIVD 263 +R VAI+D Sbjct 201 SPIRAVAILD 210 Lambda K H 0.319 0.137 0.447 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 435544382258 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40