BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1730c Length=517 Score E Sequences producing significant alignments: (Bits) Value gi|148822936|ref|YP_001287690.1| penicillin-binding protein [Myc... 1062 0.0 gi|15608868|ref|NP_216246.1| penicillin-binding protein [Mycobac... 1060 0.0 gi|15841192|ref|NP_336229.1| penicillin-binding protein 4 [Mycob... 1060 0.0 gi|298525229|ref|ZP_07012638.1| penicillin-binding protein [Myco... 1060 0.0 gi|289443192|ref|ZP_06432936.1| penicillin-binding protein [Myco... 1058 0.0 gi|289753820|ref|ZP_06513198.1| penicillin-binding protein [Myco... 1057 0.0 gi|289447345|ref|ZP_06437089.1| penicillin-binding protein [Myco... 1057 0.0 gi|289745832|ref|ZP_06505210.1| penicillin-binding protein [Myco... 1053 0.0 gi|167968658|ref|ZP_02550935.1| putative penicillin-binding prot... 1048 0.0 gi|308231914|ref|ZP_07414254.2| penicillin-binding protein [Myco... 1000 0.0 gi|323719823|gb|EGB28937.1| penicillin-binding protein [Mycobact... 998 0.0 gi|339294684|gb|AEJ46795.1| penicillin-binding protein [Mycobact... 894 0.0 gi|339298316|gb|AEJ50426.1| penicillin-binding protein [Mycobact... 834 0.0 gi|254818962|ref|ZP_05223963.1| putative penicillin-binding prot... 825 0.0 gi|240171708|ref|ZP_04750367.1| putative penicillin-binding prot... 651 0.0 gi|289757839|ref|ZP_06517217.1| penicillin-binding protein [Myco... 526 5e-147 gi|298242299|ref|ZP_06966106.1| beta-lactamase [Ktedonobacter ra... 249 8e-64 gi|269929081|ref|YP_003321402.1| beta-lactamase [Sphaerobacter t... 245 1e-62 gi|269929330|ref|YP_003321651.1| beta-lactamase [Sphaerobacter t... 238 3e-60 gi|271966638|ref|YP_003340834.1| beta-lactamase [Streptosporangi... 230 5e-58 gi|302524817|ref|ZP_07277159.1| beta-lactamase [Streptomyces sp.... 223 7e-56 gi|284042486|ref|YP_003392826.1| beta-lactamase [Conexibacter wo... 210 5e-52 gi|256393398|ref|YP_003114962.1| beta-lactamase [Catenulispora a... 207 4e-51 gi|134101816|ref|YP_001107477.1| beta-lactamase precursor [Sacch... 206 8e-51 gi|229494510|ref|ZP_04388273.1| beta-lactamase [Rhodococcus eryt... 203 7e-50 gi|271967009|ref|YP_003341205.1| beta-lactamase [Streptosporangi... 202 1e-49 gi|226304509|ref|YP_002764467.1| penicillin-binding protein [Rho... 201 3e-49 gi|256390908|ref|YP_003112472.1| beta-lactamase [Catenulispora a... 198 2e-48 gi|291297998|ref|YP_003509276.1| beta-lactamase [Stackebrandtia ... 197 3e-48 gi|302530201|ref|ZP_07282543.1| beta-lactamase [Streptomyces sp.... 197 4e-48 gi|271964669|ref|YP_003338865.1| beta-lactamase class C-like pro... 195 2e-47 gi|154251228|ref|YP_001412052.1| beta-lactamase [Parvibaculum la... 193 8e-47 gi|284032795|ref|YP_003382726.1| beta-lactamase [Kribbella flavi... 190 6e-46 gi|221635417|ref|YP_002523293.1| beta-lactamase [Thermomicrobium... 190 7e-46 gi|325929660|gb|ADZ45342.1| beta-lactamase [Streptomyces sp. NRR... 189 8e-46 gi|271967010|ref|YP_003341206.1| beta-lactamase [Streptosporangi... 184 2e-44 gi|326331741|ref|ZP_08198029.1| beta-lactamase [Nocardioidaceae ... 184 5e-44 gi|117164514|emb|CAJ88060.1| putative cmcPBP [Streptomyces ambof... 181 2e-43 gi|226304510|ref|YP_002764468.1| S9 family peptidase [Rhodococcu... 181 4e-43 gi|229494573|ref|ZP_04388336.1| beta-lactamase family protein/pe... 181 4e-43 gi|284032800|ref|YP_003382731.1| beta-lactamase [Kribbella flavi... 179 1e-42 gi|548461|sp|Q06317.1|PBP4_NOCLA RecName: Full=Penicillin-bindin... 179 1e-42 gi|291303465|ref|YP_003514743.1| beta-lactamase [Stackebrandtia ... 178 2e-42 gi|226308610|ref|YP_002768570.1| penicillin-binding protein [Rho... 178 2e-42 gi|229488910|ref|ZP_04382776.1| beta-lactamase [Rhodococcus eryt... 178 3e-42 gi|291303063|ref|YP_003514341.1| beta-lactamase [Stackebrandtia ... 176 1e-41 gi|284030432|ref|YP_003380363.1| beta-lactamase [Kribbella flavi... 175 2e-41 gi|290959971|ref|YP_003491153.1| beta-lactamase [Streptomyces sc... 174 3e-41 gi|302530195|ref|ZP_07282537.1| predicted protein [Streptomyces ... 174 3e-41 gi|300785357|ref|YP_003765648.1| beta-lactamase class C [Amycola... 170 4e-40 >gi|148822936|ref|YP_001287690.1| penicillin-binding protein [Mycobacterium tuberculosis F11] gi|253799229|ref|YP_003032230.1| penicillin-binding protein [Mycobacterium tuberculosis KZN 1435] gi|289554497|ref|ZP_06443707.1| penicillin-binding protein [Mycobacterium tuberculosis KZN 605] gi|148721463|gb|ABR06088.1| hypothetical penicillin-binding protein [Mycobacterium tuberculosis F11] gi|253320732|gb|ACT25335.1| penicillin-binding protein [Mycobacterium tuberculosis KZN 1435] gi|289439129|gb|EFD21622.1| penicillin-binding protein [Mycobacterium tuberculosis KZN 605] gi|328458984|gb|AEB04407.1| penicillin-binding protein [Mycobacterium tuberculosis KZN 4207] Length=539 Score = 1062 bits (2746), Expect = 0.0, Method: Compositional matrix adjust. Identities = 517/517 (100%), Positives = 517/517 (100%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 23 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 82 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 83 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 142 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 143 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 202 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 203 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 262 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 263 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 322 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 323 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 382 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 383 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 442 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 443 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 502 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 503 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 539 >gi|15608868|ref|NP_216246.1| penicillin-binding protein [Mycobacterium tuberculosis H37Rv] gi|31792918|ref|NP_855411.1| penicillin-binding protein [Mycobacterium bovis AF2122/97] gi|121637638|ref|YP_977861.1| putative penicillin-binding protein [Mycobacterium bovis BCG str. Pasteur 1173P2] 24 more sequence titles Length=517 Score = 1060 bits (2742), Expect = 0.0, Method: Compositional matrix adjust. Identities = 516/517 (99%), Positives = 517/517 (100%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 +CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 1 MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 >gi|15841192|ref|NP_336229.1| penicillin-binding protein 4 [Mycobacterium tuberculosis CDC1551] gi|13881414|gb|AAK46043.1| penicillin-binding protein 4 [Mycobacterium tuberculosis CDC1551] Length=539 Score = 1060 bits (2740), Expect = 0.0, Method: Compositional matrix adjust. Identities = 516/517 (99%), Positives = 516/517 (99%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 23 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 82 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 83 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 142 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 143 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 202 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 203 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 262 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 RYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 263 MRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 322 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 323 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 382 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 383 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 442 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 443 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 502 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 503 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 539 >gi|298525229|ref|ZP_07012638.1| penicillin-binding protein [Mycobacterium tuberculosis 94_M4241A] gi|298495023|gb|EFI30317.1| penicillin-binding protein [Mycobacterium tuberculosis 94_M4241A] Length=517 Score = 1060 bits (2740), Expect = 0.0, Method: Compositional matrix adjust. Identities = 515/517 (99%), Positives = 517/517 (100%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 +CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 1 MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNG+LETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 421 YEGRYIAKQVAQNGELETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 >gi|289443192|ref|ZP_06432936.1| penicillin-binding protein [Mycobacterium tuberculosis T46] gi|289569784|ref|ZP_06450011.1| penicillin-binding protein [Mycobacterium tuberculosis T17] gi|289750289|ref|ZP_06509667.1| penicillin-binding protein [Mycobacterium tuberculosis T92] gi|289416111|gb|EFD13351.1| penicillin-binding protein [Mycobacterium tuberculosis T46] gi|289543538|gb|EFD47186.1| penicillin-binding protein [Mycobacterium tuberculosis T17] gi|289690876|gb|EFD58305.1| penicillin-binding protein [Mycobacterium tuberculosis T92] Length=517 Score = 1058 bits (2735), Expect = 0.0, Method: Compositional matrix adjust. Identities = 515/517 (99%), Positives = 516/517 (99%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 +CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 1 MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGD VFRIGSTTKTFTGT Sbjct 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDPVFRIGSTTKTFTGT 120 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 >gi|289753820|ref|ZP_06513198.1| penicillin-binding protein [Mycobacterium tuberculosis EAS054] gi|289694407|gb|EFD61836.1| penicillin-binding protein [Mycobacterium tuberculosis EAS054] Length=517 Score = 1057 bits (2734), Expect = 0.0, Method: Compositional matrix adjust. Identities = 514/517 (99%), Positives = 516/517 (99%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 +CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 1 MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGD VFRIGSTTKTFTGT Sbjct 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDPVFRIGSTTKTFTGT 120 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSG+VVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGIVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 >gi|289447345|ref|ZP_06437089.1| penicillin-binding protein [Mycobacterium tuberculosis CPHL_A] gi|289420303|gb|EFD17504.1| penicillin-binding protein [Mycobacterium tuberculosis CPHL_A] Length=517 Score = 1057 bits (2733), Expect = 0.0, Method: Compositional matrix adjust. Identities = 515/517 (99%), Positives = 516/517 (99%), Gaps = 0/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 +CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 1 MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDS VRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 121 VMMRLVERGKVDLDSHVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 >gi|289745832|ref|ZP_06505210.1| penicillin-binding protein [Mycobacterium tuberculosis 02_1987] gi|289686360|gb|EFD53848.1| penicillin-binding protein [Mycobacterium tuberculosis 02_1987] Length=538 Score = 1053 bits (2723), Expect = 0.0, Method: Compositional matrix adjust. Identities = 515/517 (99%), Positives = 516/517 (99%), Gaps = 1/517 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 23 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 82 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 83 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 142 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 143 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 202 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 203 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 262 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 263 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 322 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 323 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 382 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 383 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 442 Query 421 YEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 480 YEGRYIAKQVAQNG+LETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL Sbjct 443 YEGRYIAKQVAQNGELETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGL 502 Query 481 DLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 DLGPDNKPTGSRSN VRGPDGNIAWFCSQHGRLFRRQ Sbjct 503 DLGPDNKPTGSRSN-VRGPDGNIAWFCSQHGRLFRRQ 538 >gi|167968658|ref|ZP_02550935.1| putative penicillin-binding protein [Mycobacterium tuberculosis H37Ra] gi|254550742|ref|ZP_05141189.1| penicillin-binding protein [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=511 Score = 1048 bits (2709), Expect = 0.0, Method: Compositional matrix adjust. Identities = 510/511 (99%), Positives = 511/511 (100%), Gaps = 0/511 (0%) Query 7 LSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDELDAKINA 66 +SSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDELDAKINA Sbjct 1 MSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDELDAKINA 60 Query 67 GMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLV 126 GMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLV Sbjct 61 GMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLV 120 Query 127 ERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYV 186 ERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYV Sbjct 121 ERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYV 180 Query 187 KAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSD 246 KAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSD Sbjct 181 KAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSD 240 Query 247 QIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNG 306 QIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNG Sbjct 241 QIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNG 300 Query 307 EQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVM 366 EQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVM Sbjct 301 EQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVM 360 Query 367 VPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYI 426 VPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYI Sbjct 361 VPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYI 420 Query 427 AKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDN 486 AKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDN Sbjct 421 AKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDN 480 Query 487 KPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 KPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ Sbjct 481 KPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 511 >gi|308231914|ref|ZP_07414254.2| penicillin-binding protein [Mycobacterium tuberculosis SUMu001] gi|308369510|ref|ZP_07418072.2| penicillin-binding protein [Mycobacterium tuberculosis SUMu002] gi|308370803|ref|ZP_07422791.2| penicillin-binding protein [Mycobacterium tuberculosis SUMu003] 21 more sequence titles Length=488 Score = 1000 bits (2586), Expect = 0.0, Method: Compositional matrix adjust. Identities = 487/488 (99%), Positives = 488/488 (100%), Gaps = 0/488 (0%) Query 30 VRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK 89 +RALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK Sbjct 1 MRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK 60 Query 90 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE 149 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE Sbjct 61 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE 120 Query 150 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL 209 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL Sbjct 121 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL 180 Query 210 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD 269 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD Sbjct 181 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD 240 Query 270 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW 329 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW Sbjct 241 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW 300 Query 330 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND 389 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND Sbjct 301 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND 360 Query 390 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ 449 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ Sbjct 361 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ 420 Query 450 LAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQ 509 LAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQ Sbjct 421 LAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQ 480 Query 510 HGRLFRRQ 517 HGRLFRRQ Sbjct 481 HGRLFRRQ 488 >gi|323719823|gb|EGB28937.1| penicillin-binding protein [Mycobacterium tuberculosis CDC1551A] Length=488 Score = 998 bits (2581), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/488 (99%), Positives = 487/488 (99%), Gaps = 0/488 (0%) Query 30 VRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK 89 +RALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK Sbjct 1 MRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK 60 Query 90 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE 149 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE Sbjct 61 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE 120 Query 150 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL 209 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL Sbjct 121 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL 180 Query 210 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD 269 VVAGRIIELVAGTTYESTVQRLLLDPLQLAH RYFSDQIIGLNVAASHSVVDGKPIAVTD Sbjct 181 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHMRYFSDQIIGLNVAASHSVVDGKPIAVTD 240 Query 270 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW 329 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW Sbjct 241 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW 300 Query 330 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND 389 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND Sbjct 301 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND 360 Query 390 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ 449 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ Sbjct 361 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ 420 Query 450 LAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQ 509 LAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQ Sbjct 421 LAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQ 480 Query 510 HGRLFRRQ 517 HGRLFRRQ Sbjct 481 HGRLFRRQ 488 >gi|339294684|gb|AEJ46795.1| penicillin-binding protein [Mycobacterium tuberculosis CCDC5079] Length=447 Score = 894 bits (2311), Expect = 0.0, Method: Compositional matrix adjust. Identities = 435/437 (99%), Positives = 437/437 (100%), Gaps = 0/437 (0%) Query 1 LCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 +CPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL Sbjct 1 MCPPIILSSATPTGTRCGTRHGRAVVTEYVRALDRLPHEIATAVVETVNCADPGAAFDEL 60 Query 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT Sbjct 61 DAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGT 120 Query 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD Sbjct 121 VMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDD 180 Query 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH Sbjct 181 AVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAH 240 Query 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD Sbjct 241 TRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ Sbjct 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP Sbjct 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 Query 421 YEGRYIAKQVAQNGDLE 437 YEGRYIAKQVAQNG+LE Sbjct 421 YEGRYIAKQVAQNGELE 437 >gi|339298316|gb|AEJ50426.1| penicillin-binding protein [Mycobacterium tuberculosis CCDC5180] Length=418 Score = 834 bits (2154), Expect = 0.0, Method: Compositional matrix adjust. Identities = 406/408 (99%), Positives = 408/408 (100%), Gaps = 0/408 (0%) Query 30 VRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK 89 +RALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK Sbjct 1 MRALDRLPHEIATAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVK 60 Query 90 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE 149 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE Sbjct 61 GYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADE 120 Query 150 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL 209 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL Sbjct 121 SASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGL 180 Query 210 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD 269 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD Sbjct 181 VVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTD 240 Query 270 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW 329 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW Sbjct 241 FWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW 300 Query 330 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND 389 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND Sbjct 301 VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMIND 360 Query 390 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLE 437 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNG+LE Sbjct 361 LFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGELE 408 >gi|254818962|ref|ZP_05223963.1| putative penicillin-binding protein [Mycobacterium intracellulare ATCC 13950] Length=461 Score = 825 bits (2132), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/462 (86%), Positives = 426/462 (93%), Gaps = 2/462 (0%) Query 56 AFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTK 115 AFDEL+AKINAGM AYAIPGVAVA+W GQE+VKGYGVTNVDHP+PVDGDTVFRIGSTTK Sbjct 2 AFDELEAKINAGMDAYAIPGVAVAIWVDGQEFVKGYGVTNVDHPLPVDGDTVFRIGSTTK 61 Query 116 TFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDF 175 TFTGT MMRLVE+GKV LDSPVRRYI DFAVADES ATVTVRQLLNHT GWDGRNGQDF Sbjct 62 TFTGTAMMRLVEQGKVGLDSPVRRYIHDFAVADESVGATVTVRQLLNHTGGWDGRNGQDF 121 Query 176 GRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDP 235 GRGDDAVA YV AMT LPQLT PGTAFAYNNSGLVVAGRIIELV GTTYES VQ+L+LDP Sbjct 122 GRGDDAVARYVDAMTHLPQLTAPGTAFAYNNSGLVVAGRIIELVTGTTYESAVQKLVLDP 181 Query 236 LQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQ 295 LQLAHT YFSDQIIGLNVAA H+VV G+PI ++FW FPRSCNPTGGLMSTARDQLRYA+ Sbjct 182 LQLAHTHYFSDQIIGLNVAAPHAVVGGRPIVESEFWAFPRSCNPTGGLMSTARDQLRYAR 241 Query 296 FHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGG 355 FHLGDGRAPNGEQILSR+SL+AMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGG Sbjct 242 FHLGDGRAPNGEQILSRRSLEAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGG 301 Query 356 TWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGA 415 TWKGQRSGF MVPDR+FAMTVLTNSDGGFH+INDLFA DWAL+RFAG+SNLPA PQRLG Sbjct 302 TWKGQRSGFFMVPDRDFAMTVLTNSDGGFHLINDLFARDWALRRFAGISNLPAAPQRLGP 361 Query 416 VDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYR 475 DLAPYEGRY+A QV+QNG E TVI+FRARDGQLAG+++ DANPDG ++A LGLAFYR Sbjct 362 ADLAPYEGRYLAGQVSQNGSFEQTVIEFRARDGQLAGTLT--DANPDGPDTAELGLAFYR 419 Query 476 PDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 PDYG+D+GPD KPTGSRSNFVRGPDGNIAWFC+ HGRLFRRQ Sbjct 420 PDYGIDIGPDGKPTGSRSNFVRGPDGNIAWFCTLHGRLFRRQ 461 >gi|240171708|ref|ZP_04750367.1| putative penicillin-binding protein [Mycobacterium kansasii ATCC 12478] Length=446 Score = 651 bits (1680), Expect = 0.0, Method: Compositional matrix adjust. Identities = 322/450 (72%), Positives = 376/450 (84%), Gaps = 4/450 (0%) Query 68 MKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVE 127 MKAY IPGVAV VWAGGQEYVKGYGVTNVDHP+PVD DTVFRIGSTTKTFTGT +MRLV+ Sbjct 1 MKAYGIPGVAVGVWAGGQEYVKGYGVTNVDHPVPVDADTVFRIGSTTKTFTGTTLMRLVD 60 Query 128 RGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVK 187 G VDLD+PVRRY+P+FAVAD + A VTVRQLLNHT+GW G + QDFGRGDDA++ YV Sbjct 61 EGTVDLDAPVRRYLPEFAVADPAVGAAVTVRQLLNHTSGWMGDDVQDFGRGDDALSAYVA 120 Query 188 AMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQ 247 +MTRLPQLT PGT FAYNN+GLVVAGRIIE+V G+TYES VQRLLLDPLQL HT YFSDQ Sbjct 121 SMTRLPQLTAPGTVFAYNNAGLVVAGRIIEVVTGSTYESAVQRLLLDPLQLGHTHYFSDQ 180 Query 248 IIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGE 307 I+GLNVAA+H+VVDGKP+ T FW+FPRSCNPTG L+S+ RDQLRYA+FHLGDG AP+G Sbjct 181 IVGLNVAAAHNVVDGKPVVDTGFWSFPRSCNPTGALISSVRDQLRYARFHLGDGTAPDGS 240 Query 308 QILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMV 367 ++L Q+L AMRS+PGAGGTL VELTGMGV WMLRPSAE IV+HGGTW GQRSGF MV Sbjct 241 RLLGPQALAAMRSDPGAGGTLQVELTGMGVAWMLRPSAEGPIIVQHGGTWNGQRSGFFMV 300 Query 368 PDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIA 427 P+RNFAMT+LTNS+GG + DLFA DWAL+RFAG+SNLPA PQ L A DLAP++GRY+A Sbjct 301 PERNFAMTLLTNSEGGAALTTDLFADDWALRRFAGISNLPAVPQHLSAADLAPFQGRYVA 360 Query 428 KQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGPDNK 487 + + ++G L VID R +G L G++S D G +S+ LGLAFYRPD+ +DLGPDNK Sbjct 361 ELIDESGRLGQAVIDLRVGNGHLDGTISNGDP---GTDSSRLGLAFYRPDHAIDLGPDNK 417 Query 488 PTGSRSNFVRGPDGNIAWFCSQHGRLFRRQ 517 P G+RS+FVR GNIAWF HGR+F+R+ Sbjct 418 PVGTRSDFVRDSAGNIAWF-RNHGRIFQRR 446 >gi|289757839|ref|ZP_06517217.1| penicillin-binding protein [Mycobacterium tuberculosis T85] gi|289713403|gb|EFD77415.1| penicillin-binding protein [Mycobacterium tuberculosis T85] Length=266 Score = 526 bits (1354), Expect = 5e-147, Method: Compositional matrix adjust. Identities = 254/256 (99%), Positives = 256/256 (100%), Gaps = 0/256 (0%) Query 182 VALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHT 241 +ALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHT Sbjct 1 MALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHT 60 Query 242 RYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDG 301 RYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDG Sbjct 61 RYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDG 120 Query 302 RAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQR 361 RAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQR Sbjct 121 RAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQR 180 Query 362 SGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPY 421 SGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPY Sbjct 181 SGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPY 240 Query 422 EGRYIAKQVAQNGDLE 437 EGRYIAKQVAQNG+LE Sbjct 241 EGRYIAKQVAQNGELE 256 >gi|298242299|ref|ZP_06966106.1| beta-lactamase [Ktedonobacter racemifer DSM 44963] gi|297555353|gb|EFH89217.1| beta-lactamase [Ktedonobacter racemifer DSM 44963] Length=457 Score = 249 bits (636), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 140/364 (39%), Positives = 200/364 (55%), Gaps = 7/364 (1%) Query 64 INAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMM 123 + K + IPGVAV VW G+E YGVT+VD+P+P+D +T+F +GS TK+FT T +M Sbjct 10 VETTFKTFNIPGVAVGVWLDGKEIYACYGVTSVDNPLPIDQNTLFALGSITKSFTATTLM 69 Query 124 RLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVA 183 RLV GKV+L++PVRRYIP+ + D A+ VTV LLNHT+G D R D G GDDA+ Sbjct 70 RLVAEGKVELNAPVRRYIPELQLKDTQAADKVTVLNLLNHTSGLDWRVNADTGEGDDALE 129 Query 184 LYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRY 243 YV M + + P G+ +Y+ +G + GRIIE V G T++ V L+ +PL L+H+ + Sbjct 130 RYVAKMAEVDLIAPLGSRVSYSQAGYNLLGRIIEKVTGQTFDRAVASLVFEPLGLSHSFF 189 Query 244 FSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRA 303 D I+ A H +++ W R NP GG+ S+ D LR+ +FHLGDG A Sbjct 190 ARDDIMTRRFAVGHDRSQDGTLSIARPWRHSRGDNPGGGIASSTADLLRWGRFHLGDGHA 249 Query 304 PNGEQILSRQSLKAMRSNPGA--GGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQR 361 +G ++L L M+ + TL +G+ W LR + V HGG+ GQ Sbjct 250 ESGIRVLPTHVLHQMKDSTAELRASTLG---DAIGLCWFLR-DVDGVRTAGHGGSANGQF 305 Query 362 SGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPY 421 S ++VP+RNFA+ LTN+ N WAL+ + G+ + P A Sbjct 306 SELLIVPERNFAVISLTNAGPDGIPFNQEVVR-WALENYLGIIDRDPEPISFDAARAQEI 364 Query 422 EGRY 425 G Y Sbjct 365 VGNY 368 >gi|269929081|ref|YP_003321402.1| beta-lactamase [Sphaerobacter thermophilus DSM 20745] gi|269788438|gb|ACZ40580.1| beta-lactamase [Sphaerobacter thermophilus DSM 20745] Length=454 Score = 245 bits (626), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 159/457 (35%), Positives = 236/457 (52%), Gaps = 20/457 (4%) Query 59 ELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFT 118 ELD + A M + +PG+ + + G+ + YGV +++ P+ D++F+IGS +K +T Sbjct 10 ELDGVVEAAMTRWGVPGLTLGILRDGEAETRAYGVASLESGYPLRPDSLFQIGSISKVYT 69 Query 119 GTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRG 178 T++M VE G +DLD+PV Y+PD +AD +A +TVR LL HT+G +G D+G G Sbjct 70 ATLVMTFVEEGVLDLDTPVWTYLPDLVLADAAARDAITVRHLLAHTSGLEGDRFTDYGMG 129 Query 179 DDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQL 238 DDA+ + L Q+TPPG +AY NSG + G IIE + G +E+ ++ + +PL L Sbjct 130 DDALTRAIAEFHTLRQITPPGETWAYCNSGFYLTGAIIERLTGKPFEAVMRERVFEPLGL 189 Query 239 AHTRYFSDQIIGLNVAASHSVVD-GKPI-AVTDFWTFPRSCNPTGGLMSTARDQLRYAQF 296 + +F+ + I VA HS V G+P V + PR N GG++S D LR+A F Sbjct 190 TRSFFFAHEAITYPVAVGHSPVQPGEPAHEVARRYPLPRCVNAAGGIISDVGDLLRFAAF 249 Query 297 HLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGT 356 HLGDG +G+++LS +SL AMR G+ G+ W L + + ++ HGGT Sbjct 250 HLGDGTV-DGKRVLSPESLAAMREPQAEAGSF---AEAYGLAWALH-AYDGGWVIGHGGT 304 Query 357 WKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAV 416 G ++ +VP R FA+ VLTNS G +++ DW L+ GL + P L A Sbjct 305 TGGFQAQLRLVPGRGFAVAVLTNSSQGAAAYSEII--DWVLEHECGLRPVRPEPVSLSAD 362 Query 417 DLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRP 476 +LA + GRY V D+ +V R R + S T G+ + L Sbjct 363 ELAWFAGRYHRPDV----DITISVDGDRLRADVVTRSQLT------GKETTLPPLTLIPI 412 Query 477 DYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRL 513 L D G F+ GPDG F HGRL Sbjct 413 GERRFLIADTHVRGETVEFLEGPDGA-PRFLRFHGRL 448 >gi|269929330|ref|YP_003321651.1| beta-lactamase [Sphaerobacter thermophilus DSM 20745] gi|269788687|gb|ACZ40829.1| beta-lactamase [Sphaerobacter thermophilus DSM 20745] Length=457 Score = 238 bits (606), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 135/368 (37%), Positives = 200/368 (55%), Gaps = 9/368 (2%) Query 60 LDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTG 119 LD + M ++IPG+AV ++ G GYGV +++ PV DT+F+IGS +K +T Sbjct 14 LDEAVRDAMTRWSIPGIAVGIFRDGAVETHGYGVASLETGFPVRPDTLFQIGSISKVYTA 73 Query 120 TVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGD 179 T+ M+LVE GK+ LD+PV Y+PD +AD A T+T+R LL HT+G +G D+G GD Sbjct 74 TLAMQLVEEGKLSLDTPVIEYLPDLKLADADAQRTITMRHLLTHTSGLEGDRFDDYGIGD 133 Query 180 DAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLA 239 DA+A + L Q T PG ++Y NSG +AGR++E + G T+E ++ + PL + Sbjct 134 DALAKAIAEFHTLRQWTAPGELWSYCNSGFYLAGRVMEQILGQTFEQAMRERVFAPLGME 193 Query 240 HTRYFSDQIIGLNVAASHSVV--DGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFH 297 H+ +F+ + I VA H+ V V + PR N GG+++ D LR+A FH Sbjct 194 HSFFFAHEAIVYPVAVGHTQVTPSSAEHKVARLYPLPRCVNAAGGIIANVGDLLRFAAFH 253 Query 298 LGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTW 357 + +G G+QILS +S+ AM+ G G+ W L + + V IV HGG+ Sbjct 254 MSNGTV-GGKQILSAESIAAMQEQQVKAGNF---ADAYGIGWAL-DTVDGVKIVSHGGST 308 Query 358 KGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVD 417 G ++ +VP R FA+ +LTN D G D+ WAL+ GL + P L A Sbjct 309 NGFQAQLALVPSRRFAIAILTNGDRGAAAHRDI--QRWALEHELGLRSTDPEPITLPAEA 366 Query 418 LAPYEGRY 425 L G Y Sbjct 367 LERVVGTY 374 >gi|271966638|ref|YP_003340834.1| beta-lactamase [Streptosporangium roseum DSM 43021] gi|270509813|gb|ACZ88091.1| beta-lactamase [Streptosporangium roseum DSM 43021] Length=440 Score = 230 bits (586), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 155/379 (41%), Positives = 215/379 (57%), Gaps = 20/379 (5%) Query 55 AAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTT 114 A + L + +++ ++ +PG AV V G E++ GVT+VD P PV GDT+F+IGSTT Sbjct 2 ADLNHLQSLLDSEARSLHVPGAAVGVLLDGAEHILTTGVTSVDAPAPVTGDTLFQIGSTT 61 Query 115 KTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQD 174 KT T T +M LVERG++DLD VRRY+P F +ADE A+A +T+R LL HT G+ G Sbjct 62 KTLTATTIMHLVERGRLDLDGRVRRYLPGFRLADERAAAELTIRHLLTHTGGFLGDIDDG 121 Query 175 FGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLD 234 A+A + A +LPQL PPG +YNN+G + GRI+E+V G YE+ V+R++L+ Sbjct 122 ESWDTSALADSIGAYDQLPQLFPPGALASYNNAGFRLLGRIVEVVCGEPYENAVRRVVLE 181 Query 235 PLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYA 294 PL ++ + +F + A H+V + P V W R GGL+S+ RDQLRYA Sbjct 182 PLGMSSSFFFPWEAATRPHAVGHAVREEGP-QVAHTWGLFREGMAEGGLVSSVRDQLRYA 240 Query 295 QFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHG 354 FHLG G GE ++ + + M++ G W TG+G+ W+L A V +V HG Sbjct 241 AFHLGAG----GEVPVAAATRELMQAEHVRVGVPW---TGIGLPWLLEEQA-GVRLVTHG 292 Query 355 GTWKG-QRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQ-- 411 G Q S FV+ P+R FA+T LTNS G + +DW L+ L A PQ Sbjct 293 GNIGNLQLSTFVLAPERGFAVTTLTNSASG--KVLGKLVTDWCLEHL-----LDAKPQAV 345 Query 412 RLGAVDLAP-YEGRYIAKQ 429 RL AP Y G Y A Q Sbjct 346 RLALRGPAPEYAGSYDAGQ 364 >gi|302524817|ref|ZP_07277159.1| beta-lactamase [Streptomyces sp. AA4] gi|302433712|gb|EFL05528.1| beta-lactamase [Streptomyces sp. AA4] Length=460 Score = 223 bits (568), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 152/429 (36%), Positives = 226/429 (53%), Gaps = 25/429 (5%) Query 50 CADPGAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFR 109 C + DEL + + +PGV+ + G+E + GV++VD PVD DT+F Sbjct 14 CEAGRMSTDELRGLLGEWAREAGVPGVSAGILHEGKETLLTTGVSSVDTGTPVDDDTLFM 73 Query 110 IGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDG 169 IGST+KTF ++ LVE G ++LD PV Y+P+ ++D A+ TVT+R LL H++G+ G Sbjct 74 IGSTSKTFAAAAVLVLVEDGVLELDQPVVEYLPELRLSDPLATKTVTLRHLLTHSSGFLG 133 Query 170 RNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQ 229 D G GDDA+A V+ LPQ+ P G F+Y N+G ++AGR+ E V+G TYE V+ Sbjct 134 DIEVDTGWGDDALARAVERFGELPQIFPVGEVFSYCNAGFLLAGRVAEAVSGGTYEDLVR 193 Query 230 RLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARD 289 LL+PL + + + +++ A H++ + P AV R+ P GGL STARD Sbjct 194 TRLLEPLGMTDSYFQPWEVLTRRHAVGHALREDGP-AVAHTVGLSRADAPAGGLWSTARD 252 Query 290 QLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVT 349 QL++A+F L +G ++LS + + M + G + E +G++W LR + Sbjct 253 QLKWARFQL------DGGEVLSDGTRRLMHAAQRKGALPFEE---VGLSW-LRLRHGDAQ 302 Query 350 IVEHGGTWKG-QRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPA 408 +V HGG Q S FVM P N A+TVLTNS GG + + DW L+ A L + Sbjct 303 LVRHGGNVSNLQLSEFVMAPSENLAVTVLTNSAGGGALGPRVV--DWCLENLADLPKPGS 360 Query 409 TPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSAN 468 P + A+D GRY + G L + D RDG L M D +PD ++ Sbjct 361 LP--VWAIDPGDCLGRY------RTGSL---IFDITERDGSLWAQMILDTDDPDILSAPP 409 Query 469 LGLAFYRPD 477 + F D Sbjct 410 FEVVFVAED 418 >gi|284042486|ref|YP_003392826.1| beta-lactamase [Conexibacter woesei DSM 14684] gi|283946707|gb|ADB49451.1| beta-lactamase [Conexibacter woesei DSM 14684] Length=461 Score = 210 bits (534), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 130/372 (35%), Positives = 198/372 (54%), Gaps = 14/372 (3%) Query 60 LDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTG 119 L ++ + Y +PG +VAV AGGQ G+ N+D + D++F+IGS TK +T Sbjct 14 LHGRLEELVARYDVPGASVAVLAGGQVATAAAGLLNLDTGVAATADSLFQIGSITKLYTA 73 Query 120 TVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGD 179 T++M+LV+ G++DLD+P Y+P+ +AD +A VTVR LL+HT+G G + D GRGD Sbjct 74 TLVMQLVDEGRIDLDAPAVTYLPELKLADPEVTAAVTVRHLLSHTSGIAGDHFPDLGRGD 133 Query 180 DAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLA 239 D VA YV + L Q P G +Y NSG V+AGRI+EL+ G +++ + L+ PL ++ Sbjct 134 DVVARYVASCAELGQTLPLGATTSYCNSGFVIAGRIVELLTGQSWDDALASRLVAPLGVS 193 Query 240 HTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLG 299 T + ++ A H DG+ V+ WT PR+C P G + +TA D + +A+ +L Sbjct 194 RTFTQPEDVLRFRSALGHMEQDGELRPVSQ-WTLPRACGPAGLICATAADVVAFARTYLD 252 Query 300 DGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWM----LRPSAENVTIVEHGG 355 GR P G Q+LS +S+ AM A + + G+ W +RP + H G Sbjct 253 AGRTPAGVQLLSPESVAAMLEPRAALPDTYTMGSHFGLGWAAFDGVRPR-----VYGHNG 307 Query 356 TWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPAT--PQRL 413 GQ S +VP + A+ +LTN + + L L+ AG++ P P Sbjct 308 GTVGQASFLRVVPGADVAIALLTNGGHAADLFDGLVRP--LLEEVAGVATPPPLEPPSVA 365 Query 414 GAVDLAPYEGRY 425 V L P+ G Y Sbjct 366 THVALDPHAGVY 377 >gi|256393398|ref|YP_003114962.1| beta-lactamase [Catenulispora acidiphila DSM 44928] gi|256359624|gb|ACU73121.1| beta-lactamase [Catenulispora acidiphila DSM 44928] Length=464 Score = 207 bits (527), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 130/330 (40%), Positives = 184/330 (56%), Gaps = 19/330 (5%) Query 59 ELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFT 118 +L A ++ + +PG AVAV AG Q GV N++ + D++F+IGS TKT T Sbjct 10 DLIALLDTATRENHVPGAAVAVSAGDQVIELATGVLNLNTGVTATPDSLFQIGSITKTLT 69 Query 119 GTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRG 178 T+ M+LV+ G VDLD PVR Y+P+ AV+D A+ TVTVRQLL+HT+G G DFGRG Sbjct 70 ATLTMQLVDAGLVDLDEPVRTYVPELAVSDREAAETVTVRQLLSHTSGLPGDVFTDFGRG 129 Query 179 DDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGT-TYESTVQRLLLDPLQ 237 DDAV YV+ + Q+ PG ++Y N+G V G +++ + ++E+ ++ L+ PL Sbjct 130 DDAVLRYVEGLKDHEQMYEPGRMYSYCNAGYSVLGLMVQRIRELPSWEAVLREHLIAPLG 189 Query 238 LAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGG-LMSTARDQLRYAQF 296 L H +++ + A H + DGK +A W PRS P G + ARD L +A+ Sbjct 190 LTHVAALAEEALLFRTAVGH-LDDGKKVA--PIWQLPRSAAPAGASTCARARDLLTFARM 246 Query 297 HLGDGRAPNGEQILSRQSLKAMRSN----PGAG---GTLWVELTGMGVTWMLRPSAENVT 349 H+ G A +G +ILS +S+ AMR PG+G GT W G+G + RP Sbjct 247 HMNGGLAQDGTRILSEESVAAMREQQVALPGSGNLLGTGW----GLGFGLIDRPGGR--- 299 Query 350 IVEHGGTWKGQRSGFVMVPDRNFAMTVLTN 379 +V H G GQ S VPD A VLTN Sbjct 300 VVGHNGGTIGQSSQMRFVPDEGVAFAVLTN 329 >gi|134101816|ref|YP_001107477.1| beta-lactamase precursor [Saccharopolyspora erythraea NRRL 2338] gi|291009221|ref|ZP_06567194.1| beta-lactamase precursor [Saccharopolyspora erythraea NRRL 2338] gi|133914439|emb|CAM04552.1| beta-lactamase precursor [Saccharopolyspora erythraea NRRL 2338] Length=458 Score = 206 bits (524), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 125/360 (35%), Positives = 195/360 (55%), Gaps = 21/360 (5%) Query 59 ELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFT 118 EL + A + IPGVA VWA G+E +G+T+VD+P PVD T+F + S TKTFT Sbjct 5 ELAGAVEAAATEFGIPGVAAGVWADGREIRASHGITSVDNPRPVDETTLFHLASVTKTFT 64 Query 119 GTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRG 178 T ++RL GKV+L +PV Y+P+ ++DE A+A +TV LLNHT+G D N + G Sbjct 65 ATALVRLAAEGKVELAAPVLHYVPELRLSDERAAAKITVWHLLNHTSGLD-WNVVEAGDE 123 Query 179 DDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQL 238 D++A +V M LP + PG +Y+ + +AG ++E V G +E V L+L+P+ L Sbjct 124 ADSLAGFVARMAGLPMIGEPGERASYSQAAYNLAGLVVEKVTGLPFEKAVASLVLEPVGL 183 Query 239 AHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTF----PRSCNPTGGLMSTARDQLRYA 294 +T + D ++ + A H+ D + W R +P GG++S+ D LR+A Sbjct 184 TNTFFDLDDVVVRSFAVGHNRGDDGELRFARPWKAWRAGARGNDPGGGIVSSVGDLLRWA 243 Query 295 QFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELT----GMGVTWMLRPSAENVTI 350 +FHLG G+ +L +L MR T+ + + G+G+ W LR V Sbjct 244 RFHLG-----TGDGVLPADALHRMREQ-----TVALRASSLGDGVGICWFLR-DVGGVRT 292 Query 351 VEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATP 410 + HGG+ GQ + ++VP+R+FA+ L+N+ H N WAL+ + G+ + P Sbjct 293 IGHGGSGNGQFAELLIVPERDFAVVSLSNAGPDGHPCNRAVVR-WALEHYLGVVDRDPQP 351 >gi|229494510|ref|ZP_04388273.1| beta-lactamase [Rhodococcus erythropolis SK121] gi|229318872|gb|EEN84730.1| beta-lactamase [Rhodococcus erythropolis SK121] Length=473 Score = 203 bits (516), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 130/349 (38%), Positives = 191/349 (55%), Gaps = 14/349 (4%) Query 73 IPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVD 132 IPGV+V + G ++ V G+ +V+ +PV T+F IGSTTK F T M LVE G +D Sbjct 45 IPGVSVGIVHGDKDIVVTSGIESVETQLPVTDKTMFMIGSTTKVFAATAAMALVEDGLLD 104 Query 133 LDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRL 192 LD+P+ Y+P+ ADE A+ TVT+R LL HT G+ G G G+DA+ V + L Sbjct 105 LDTPLVEYVPELTFADEEATRTVTMRHLLTHTGGFTGDASLSAGWGEDALGRSVSRLKEL 164 Query 193 PQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLN 252 Q P G F+Y+NSG V+AG ++ ++G T+E V++ +LDPL++ ++ + ++ Sbjct 165 RQEFPVGEVFSYSNSGFVLAGHVVAKISGLTFEELVKQRVLDPLEMKNSAFLPWDVMTHR 224 Query 253 VAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSR 312 A H + DG P V++ R P GG+ S+ RDQL +A++ L G P Q L Sbjct 225 FALGHYIRDGVPF-VSNETGLDRGMTPCGGMWSSVRDQLVWARYAL-SGEHPGEGQPLD- 281 Query 313 QSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKG-QRSGFVMVPDRN 371 +S + + P + E G+G W+L +V HGG Q S F+ VP++N Sbjct 282 ESTRLLMQKPQRPAAMMFEEVGIG--WLLTRYG-TTQVVRHGGNVSNLQVSEFMTVPEKN 338 Query 372 FAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAP 420 FA+TVLTN+ GG I DW + A L+ LP TP L V+ P Sbjct 339 FAVTVLTNALGGG--IGKKIV-DWCM---ANLAELP-TPASLDVVEPEP 380 >gi|271967009|ref|YP_003341205.1| beta-lactamase [Streptosporangium roseum DSM 43021] gi|270510184|gb|ACZ88462.1| beta-lactamase [Streptosporangium roseum DSM 43021] Length=446 Score = 202 bits (514), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 140/406 (35%), Positives = 212/406 (53%), Gaps = 25/406 (6%) Query 57 FDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKT 116 + L + + + + +PG A+A+WAGG+ GV N + + D+VF++GSTTK Sbjct 2 LENLQERFDEAARRHGVPGAALALWAGGRLVEVATGVVNRNIGVETTTDSVFQVGSTTKV 61 Query 117 FTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFG 176 +T ++M+LV+ G V+LD PV Y+P+FAVAD A +TVR LL HT G+DG +D G Sbjct 62 WTAALVMQLVDEGLVELDRPVGDYLPEFAVAD-GAEKAITVRHLLTHTGGFDGDLFEDTG 120 Query 177 RGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPL 236 RGDD + YV + + PG F+Y N+G V G ++ V GTT+E ++ LLDPL Sbjct 121 RGDDCLDKYVDFLHDAGHVHAPGALFSYCNAGYCVLGALVARVRGTTWEQVMRERLLDPL 180 Query 237 QLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTA-RDQLRYAQ 295 H+ ++ I AA H +G V W PRS P G M A R+ +R+ + Sbjct 181 GATHSALLPEEAILFRAAAGHVGPEGT---VHHRWDMPRSNAPAGSTMCLAPRELVRFGR 237 Query 296 FHLGDGRAPNGEQILSRQSLKAMRSN----PGAGGTLWVELTGMGVTWMLRPSAENVTIV 351 + G A +G ++LS +S+ AMR+ PG G L + G+G + E + Sbjct 238 MFIAGGLAEDGTRLLSEESVAAMRTGQVEVPGISGLL-ADRWGLGFE-LFDWGGE---VY 292 Query 352 EHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLS--NLPAT 409 H G GQ + + +VP +FA+ + N G ++ D+ ++ GL+ P Sbjct 293 GHDGGTIGQSTFWRVVPGADFAIAMSANGGGFLGLLVDVVLP--LIREVTGLAVPEFPVP 350 Query 410 PQRLGAVDLAPYEGRY----IAKQVAQ-NGDLETTVI--DFRARDG 448 G VD PY GRY IA +VA+ +G L+ T+I +F R G Sbjct 351 AATPGVVDPTPYTGRYEGPMIAYEVAEADGGLDITMIPGEFMVRAG 396 >gi|226304509|ref|YP_002764467.1| penicillin-binding protein [Rhodococcus erythropolis PR4] gi|226183624|dbj|BAH31728.1| putative penicillin-binding protein [Rhodococcus erythropolis PR4] Length=473 Score = 201 bits (511), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 134/374 (36%), Positives = 202/374 (55%), Gaps = 25/374 (6%) Query 73 IPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVD 132 IPGV+V + G ++ V G+ +V+ +PV T+F IGSTTK F T M LVE G +D Sbjct 45 IPGVSVGIVHGDKDIVVTSGIESVETQLPVTDKTMFMIGSTTKVFAATAAMALVEDGLLD 104 Query 133 LDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRL 192 LD+P+ Y+P+ +AD+ A+ TVT+R LL HT G+ G G G+DA+ + + L Sbjct 105 LDTPLVEYVPELILADDEATRTVTMRHLLTHTGGFTGDASLSAGWGEDALGRSISRLKEL 164 Query 193 PQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLN 252 Q P G F+Y+NSG V+AG ++ ++G T+E V++ +LDPL++ ++ + ++ Sbjct 165 RQEFPVGEVFSYSNSGFVLAGYVVAKISGLTFEELVKQRVLDPLEMKNSAFLPWDVMTHR 224 Query 253 VAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSR 312 A H + +G+P V++ R P GG+ S+ RDQL +A++ L G P Q L Sbjct 225 FALGHYIREGEPF-VSNETGLDRGMTPCGGMWSSVRDQLVWARYAL-SGEHPGEGQPLD- 281 Query 313 QSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKG-QRSGFVMVPDRN 371 +S + + P + E G+G W+L +V HGG Q S F+ VP++N Sbjct 282 ESTRLLMQKPQRPAAMMFEEVGIG--WLLTRYG-TTQVVRHGGNVSNLQVSEFLTVPEKN 338 Query 372 FAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYE-----GRYI 426 FA+TVLTN+ GG I DW + A L+ LPA P L V+ P G+Y Sbjct 339 FAVTVLTNALGGG--IGKKIV-DWCM---ANLAELPA-PASLDVVEPEPSAVDAVLGKY- 390 Query 427 AKQVAQNGDLETTV 440 Q G+L TV Sbjct 391 -----QAGNLTMTV 399 >gi|256390908|ref|YP_003112472.1| beta-lactamase [Catenulispora acidiphila DSM 44928] gi|256357134|gb|ACU70631.1| beta-lactamase [Catenulispora acidiphila DSM 44928] Length=463 Score = 198 bits (504), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 164/477 (35%), Positives = 233/477 (49%), Gaps = 43/477 (9%) Query 59 ELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFT 118 EL A + KAY +PGV+V V G+EY T+VD VD T+F I S TK+FT Sbjct 9 ELAAFVAEAAKAYDVPGVSVGVLLDGREYF-----TSVD----VDERTLFHIASVTKSFT 59 Query 119 GTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAG--WD-----GRN 171 T +MRL G++DL++PVR Y+P+ +ADE+ +A +TVR LL+HT G W+ Sbjct 60 ATALMRLAAEGRIDLEAPVRTYVPELKLADETHAARITVRNLLDHTGGLEWNLIDTGSGT 119 Query 172 GQDFGR--GDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQ 229 G D G GD ++A +V + LP + PG +Y+ +G + GR+IE V G +YE V Sbjct 120 GTDSGTADGDGSLAAFVAKLVALPLIAEPGVRASYSQAGYNLLGRVIEKVTGQSYERAVA 179 Query 230 RLLLDPLQLAHTRYFSDQIIGLNVAASHSV-VDGKPIAVTDFWTFPRSC---NPTGGLMS 285 L+L PL L T + D ++ A H+ DG A T + ++P NP GG +S Sbjct 180 ELVLTPLGLIDTVFDLDDVMVRTFAVGHNRDADGVLHAATPWKSYPAGTHGNNPGGGGVS 239 Query 286 TARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGA--GGTLWVELTGMGVTWMLRP 343 A D LR+A+FHLG+ + EQ+LS ++ +AMR G TL G W L Sbjct 240 CAADLLRWARFHLGE-QVGAAEQVLSVEARRAMREPKSELRGSTLG---DAFGFGWFLNE 295 Query 344 SAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGL 403 V HGG+ GQ + + VP+R FA+ VL+N+ G+ + D+ WAL+ F + Sbjct 296 IG-GVRTFGHGGSGNGQFAELLAVPERGFAIAVLSNATEGYQLNQDIV--KWALEHFLAV 352 Query 404 SNLPATPQRLGAVDLAPYEGRY----IAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDA 459 P A GRY + +A +G+ T + + + S D Sbjct 353 VEQDPEPVAYDADRNRAVVGRYEIDAMNLDIADDGEHLTLAVGIKPE----IRAASDADM 408 Query 460 NPDGQNSANLGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQHGRLFRR 516 PD +A LA DY + G G R F R G I GRLF R Sbjct 409 PPDYPAAAMGFLAADGDDYIITEG---GLKGQRGVFARDESGAIVG-IDIAGRLFGR 461 >gi|291297998|ref|YP_003509276.1| beta-lactamase [Stackebrandtia nassauensis DSM 44728] gi|290567218|gb|ADD40183.1| beta-lactamase [Stackebrandtia nassauensis DSM 44728] Length=455 Score = 197 bits (501), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 130/373 (35%), Positives = 198/373 (54%), Gaps = 17/373 (4%) Query 58 DELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTF 117 D L A++ + + PG + V++ G+ +G GV N + V D VF+IGS TK + Sbjct 9 DRLGARLTELIAECSTPGAVLGVYSKGEFTERGAGVLNTRTGVEVTPDAVFQIGSITKVW 68 Query 118 TGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGR 177 T ++MRLVE G++DLD+PVR Y+P F +A+ESA+A++T RQLL+HTAG++G D G Sbjct 69 TAALVMRLVEAGELDLDAPVRSYLPKFRLAEESAAASITTRQLLSHTAGFEGDIFTDTGP 128 Query 178 GDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQ 237 GDD++A +V + PQ+ PG F+YNN+G V G ++E + G Y ++ L+ PL+ Sbjct 129 GDDSLAKFVDLLHDAPQVFEPGELFSYNNAGYCVLGLLVETLRGKPYLQCLREDLIQPLE 188 Query 238 LAHTRYFSDQIIGLNVAASH-SVVDGKPIAVTDFWTFPRSCNPTG-GLMSTARDQLRYAQ 295 L H + + I A H +P W PRS P G L +ARD L +A+ Sbjct 189 LTHAAVDAAEAILHRAAVGHFQPDPDQPPQPAGVWALPRSLAPAGSALTMSARDLLTFAR 248 Query 296 FHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW--VELTGMGVTWMLRPSAENVTIVEH 353 + D + +L +S++AMR+ LW + G+G+ L + VT+ H Sbjct 249 ALMSD------DGVLGGESIRAMRTEQVRLPVLWGNEDAWGLGLRLTL---VDGVTVCGH 299 Query 354 GGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATP-QR 412 G GQ + VP+R+ A+ +LTN M +LF L+ A + PA P Sbjct 300 NGDTIGQHAFLRFVPERDLAVVLLTNGGEVAAMFEELFGE--TLRELADVEP-PALPVPG 356 Query 413 LGAVDLAPYEGRY 425 G +D + Y G Y Sbjct 357 SGRIDASRYLGSY 369 >gi|302530201|ref|ZP_07282543.1| beta-lactamase [Streptomyces sp. AA4] gi|302439096|gb|EFL10912.1| beta-lactamase [Streptomyces sp. AA4] Length=461 Score = 197 bits (500), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 132/376 (36%), Positives = 193/376 (52%), Gaps = 16/376 (4%) Query 60 LDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTG 119 L A + + +PG A+AV A G+ GV N + D+VF+IGS TK +T Sbjct 11 LQENFAALLAKHQVPGAAIAVLADGEVIDHAAGVVNKGTGVESTVDSVFQIGSITKVWTT 70 Query 120 TVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGD 179 T+ M+LV+ GK+DLD PVR Y+P+FA+ D+ A+A +TVRQL HT+G++G D G GD Sbjct 71 TLAMQLVDEGKLDLDRPVRDYLPEFALGDDEAAAVITVRQLTCHTSGFEGDIFTDTGPGD 130 Query 180 DAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLA 239 D V V ++ +PQL PPG F+YNN+G V GR+IE++ G ++ V+ L PL L Sbjct 131 DCVEKLVATLSDVPQLFPPGERFSYNNAGYCVLGRVIEVLRGKCWDDCVREHLFAPLGLT 190 Query 240 HTRYFSDQIIGLNVAASH-SVVDGKPIAVTDFWTFPRSCNPTGGLMST-ARDQLRYAQFH 297 H I A H S G+ W RS P G ++ RD L + + H Sbjct 191 HAASGPYDAIRYRAAIGHISPKPGEDPVPAPVWALTRSNAPAGSTLAMRPRDLLTFVRMH 250 Query 298 LGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGM----GVTWMLRPSAENVTIVEH 353 L DG+A +G Q++ +SL AMR + + V GM G+ WML + ++ H Sbjct 251 LNDGKADDGTQVVLPESLLAMRES-----QVDVPDLGMSDHWGLGWMLF-DWDGGKVIGH 304 Query 354 GGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLS--NLPATPQ 411 G GQ S +VP++ A+ +LTN + ++F L AG++ P Sbjct 305 DGGTIGQSSFLRVVPEKGVAVALLTNGGQPLNAYQEIFTK--LLDELAGVTVPARPEPNP 362 Query 412 RLGAVDLAPYEGRYIA 427 DL+ Y G Y + Sbjct 363 AAAPADLSRYLGEYTS 378 >gi|271964669|ref|YP_003338865.1| beta-lactamase class C-like protein [Streptosporangium roseum DSM 43021] gi|270507844|gb|ACZ86122.1| Beta-lactamase class C and other penicillin binding protein-like protein [Streptosporangium roseum DSM 43021] Length=484 Score = 195 bits (495), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 131/396 (34%), Positives = 200/396 (51%), Gaps = 23/396 (5%) Query 54 GAAFDELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGST 113 G + D A+++ A+ +PG ++AV AGG + GV + + V D+VF GS Sbjct 28 GFSLDRWQARLDELCAAHHVPGASLAVLAGGDIHELASGVLHRGTGVEVTTDSVFLSGSL 87 Query 114 TKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQ 173 K +T T++ +LV+ G++ LD+PV +P+FA D A+ T+T+RQLL+HT G Sbjct 88 AKVYTATLVTQLVDSGELALDAPVVSVLPEFATPDAEATKTITIRQLLSHTGGLTCDFTY 147 Query 174 DFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLL 233 D GRGDD +A YV+A + PPGTA +Y++ G VV GR++E++ G T++ ++ ++ Sbjct 148 DSGRGDDCLAKYVEAAREVALDCPPGTAISYSSLGYVVLGRVVEVLTGKTWDRALKDMIF 207 Query 234 DPLQLAHTRYFSDQIIGLNVAASH---SVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQ 290 PL L H+ ++ + VA H D P D PRS P G ++ +A D Sbjct 208 TPLGLEHSMTLPEEALRFRVAMGHLGEPGTDPDPAPAWDL--MPRSAGPYGRVIISAGDV 265 Query 291 LRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLW-VELTGMGVTWMLRPSAENVT 349 R+A+ HL G AP+G ++LS ++ AM+ W V G G+ W L + V Sbjct 266 ARFARMHLDGGTAPDGTRVLSADAVAAMQRREVDSPDKWTVSADGWGLGWTLY-DWDGVP 324 Query 350 IVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPAT 409 H G+ Q S +VP A+ +LTN G H+ DLF L+ AG+ Sbjct 325 GYGHDGSAVAQHSYLRVVPHAGVAVVLLTNGGGTGHLYADLFRE--LLEELAGVR----M 378 Query 410 PQRLG------AVDLAPYEGRY----IAKQVAQNGD 435 P G VD+ P G Y + V Q+ D Sbjct 379 PDAFGPAANPPVVDMTPLVGTYKREGVVTTVTQDDD 414 >gi|154251228|ref|YP_001412052.1| beta-lactamase [Parvibaculum lavamentivorans DS-1] gi|154155178|gb|ABS62395.1| beta-lactamase [Parvibaculum lavamentivorans DS-1] Length=431 Score = 193 bits (490), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 123/351 (36%), Positives = 189/351 (54%), Gaps = 6/351 (1%) Query 78 VAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPV 137 +AVWA G+ + GV N++ +PV DT+F+IGS TK +T ++M+LVE GK+DL++PV Sbjct 1 MAVWADGEGFEAAAGVCNLETRVPVTSDTLFQIGSITKLYTAALVMQLVEEGKLDLEAPV 60 Query 138 RRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTP 197 R+ +P+F V DE+ +A VT+RQLL+HT+G G +D GRG+D VA +V M L Q+ Sbjct 61 RKVLPEFRVKDEAVAARVTLRQLLSHTSGITGDYFKDAGRGEDRVARFVSMMAGLEQVHQ 120 Query 198 PGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASH 257 PG F+Y N+G V AGR+IE+ GTT++ ++ + L +Q + A H Sbjct 121 PGEMFSYCNTGFVAAGRMIEVANGTTWDKAIRTRIAKILDTPAFSTLPEQAMRYQTAIGH 180 Query 258 SVVDGKPIAVTDFWTFPRSCNPTGGL-MSTARDQLRYAQFHLGDGRAPNGEQILSRQSLK 316 G + VT S P G M+ ARD + +A+ + +G APNG+Q+L+ +S+ Sbjct 181 LGAPGA-LMVTPIAYLAASNGPAGATPMAKARDIVTFARMMMNEGVAPNGKQVLTAESVH 239 Query 317 AMR-SNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMT 375 AM N + ++ G+ + + H G+ GQ + P+ A Sbjct 240 AMHLRNIICPKGMNIDAIGLASFMWDWNGNGHYEVFGHDGSTIGQAAWLRYHPESETAFC 299 Query 376 VLTNSDGGFHMINDLFASDWALQRFAGLS-NLPATPQRLGAVDLAPYEGRY 425 +LTN G M + L +A + AG++ PA P +D A Y GRY Sbjct 300 LLTNGGNGKAMADALIREVFAAE--AGIAPPEPAKPDPALVLDAARYAGRY 348 >gi|284032795|ref|YP_003382726.1| beta-lactamase [Kribbella flavida DSM 17836] gi|283812088|gb|ADB33927.1| beta-lactamase [Kribbella flavida DSM 17836] Length=470 Score = 190 bits (482), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 130/389 (34%), Positives = 201/389 (52%), Gaps = 20/389 (5%) Query 60 LDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTG 119 LD ++ + Y +PG AVAV G+ GV ++ + D+VF++GS TK +T Sbjct 11 LDDRLATLLTEYDVPGAAVAVSLRGEVIDTAAGVLSLATGVDATADSVFQVGSITKVWTA 70 Query 120 TVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGD 179 T++M+LV+ G V LD+PVR Y+P F VADE+A+A +TVRQLLNHTAG++G D G GD Sbjct 71 TLVMQLVDEGLVKLDAPVRDYVPGFVVADEAAAAAMTVRQLLNHTAGFEGDIFIDTGNGD 130 Query 180 DAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLA 239 D V YV + + QL PG F+YNN+ V GR++EL + ++ L+ PL L Sbjct 131 DCVEKYVAQLAGVTQLFAPGEMFSYNNAAFSVLGRLVELARNKPFAQCLRDHLVSPLGLT 190 Query 240 HTRYFSDQIIGLNVAASHSVVDGKP-----IAVTDFWTFPRSCNPTGGLMST-ARDQLRY 293 H +++ I A H KP +A W+ RS P G +++ RD + + Sbjct 191 HVANDANEAILHRAAVGHI----KPAPDADLAPAPVWSLMRSMAPAGAMLAMRPRDLVAF 246 Query 294 AQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEH 353 AQ HL G+AP+G +++S S+ AM+ L + G+ W + T++ H Sbjct 247 AQLHLDAGKAPDGTEVVSPSSVAAMQGRQVELPPLGMMGDAWGLGWEIF-DWSGRTVIGH 305 Query 354 GGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSN--LPATP- 410 G GQ + +VP++ ++ +LTN + + L+ AG++ LP P Sbjct 306 DGGTIGQGAFLRIVPEQELSVALLTNGGNLIGLYEQVVGH--VLRELAGIAMPPLPTPPA 363 Query 411 QRLGAVDLAPYEGRYIAK----QVAQNGD 435 +R +D Y G Y V+Q+ D Sbjct 364 EREPLLDATRYAGTYTCDVADITVSQDAD 392 >gi|221635417|ref|YP_002523293.1| beta-lactamase [Thermomicrobium roseum DSM 5159] gi|221158014|gb|ACM07132.1| beta-lactamase [Thermomicrobium roseum DSM 5159] Length=431 Score = 190 bits (482), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 106/300 (36%), Positives = 169/300 (57%), Gaps = 7/300 (2%) Query 84 GQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPD 143 G+E V +GV +++ PV DT+F+IGS +K + T+ MRLVE GK+ LD+PV +P+ Sbjct 10 GREVVT-HGVASLETGCPVRRDTLFQIGSISKVYLATLAMRLVEEGKLTLDTPVASVLPE 68 Query 144 FAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFA 203 +AD A +T+ LL HT+G +G D+G GDDA+A YV + Q+ PPG ++ Sbjct 69 LELADREAQQAITLWHLLTHTSGIEGDRFDDYGYGDDALARYVAGLASARQIHPPGQHWS 128 Query 204 YNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGK 263 Y NSG +AGR+IE+V G ++E+ ++ L+ PL L + + ++G A H + Sbjct 129 YCNSGFSLAGRLIEVVTGRSFEAAMRELIFGPLGLERSCFLVQDVLGYPFAVGHRTDEHG 188 Query 264 PIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPG 323 + V + PRS +P GG+ +T D L +A FHL G P +S S+ M++ P Sbjct 189 HVGVVRDFALPRSVHPAGGVWATIDDLLDFAAFHL--GLRPVAAPPISWDSITMMQA-PQ 245 Query 324 AGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGG 383 W + G+G W + S +V ++ HGG+ G ++ V++P+ A+ LTN + G Sbjct 246 VAAANWADWYGLG--WAIW-SIGSVRVIGHGGSTNGYQAHLVLLPEERVAIASLTNHEQG 302 >gi|325929660|gb|ADZ45342.1| beta-lactamase [Streptomyces sp. NRRL 30471] Length=466 Score = 189 bits (481), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 136/463 (30%), Positives = 219/463 (48%), Gaps = 38/463 (8%) Query 58 DELDAKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTF 117 ++L + A + +PG +AV GG+ + YGV N + + DT+ +GS K + Sbjct 19 EQLRELLRAAAPKHDVPGAVLAVSHGGERFAGAYGVANSRAHLEMTTDTLIPVGSFAKVW 78 Query 118 TGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGR 177 T ++M+LV+ G VDLD P+RR++P+F +AD A+ VT+R LL HT G+ G + +DFG Sbjct 79 TAVLVMQLVDEGVVDLDDPIRRHLPEFVLADAKAAERVTIRHLLTHTGGFYGDSFEDFGP 138 Query 178 GDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQ 237 GDDA A YV A+ R QL PG F+Y N+G +V G ++ V G T+E ++ ++ PL Sbjct 139 GDDAPARYVAALERAAQLHEPGELFSYCNAGFIVLGHLVAKVRGGTWEEQIRSRVMRPLG 198 Query 238 LAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMS-TARDQLRYAQF 296 L D+ + + H V G+P + W R + G ++ +A L + + Sbjct 199 LRDVALNGDEAVLFRNSVGHVVTSGRP-RIVPRWESLRCGSAAGAMLRMSAESALTFCEA 257 Query 297 HLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTG------MGVTWMLRPSAENVTI 350 H+ GR NG+ +LS +S AM + WV++ G G+ W L +V Sbjct 258 HVRQGRGANGKTLLSARSTAAMHHD-------WVDVPGSTLSDQWGIGWALWDWDGSVAF 310 Query 351 VEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLS--NLPA 408 H G ++GQ V + + + + N M +D+ + +++ G+ P Sbjct 311 -GHDGEFRGQAILIRNVAEHHLTVVLAVNGGRAREMYDDVVPA--LIEQLTGVRAPRTPG 367 Query 409 TPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSAN 468 P+ VD Y G Y Q D + TV A DG+ +TD P G + Sbjct 368 LPRDPTPVDARRYAGTY------QGPDCQYTVTP--APDGRTLLVTTTDPRKPQGHEDGS 419 Query 469 LGLAFYRPDYGLDLGPDNKPTGSRSNFVRGPDGNIAWFCSQHG 511 PD+ + L D T + + RG D +++ HG Sbjct 420 -------PDHYVRLAGD---TFIQKSHKRGTDRILSFVGDDHG 452 >gi|271967010|ref|YP_003341206.1| beta-lactamase [Streptosporangium roseum DSM 43021] gi|270510185|gb|ACZ88463.1| beta-lactamase [Streptosporangium roseum DSM 43021] Length=437 Score = 184 bits (468), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 148/447 (34%), Positives = 211/447 (48%), Gaps = 47/447 (10%) Query 66 AGMKA-YAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMR 124 AG+ A Y +PG +A G+ + GV NVD + V D++F+IGS +K +T T +M Sbjct 11 AGLIAEYEVPGANLAFLHEGEVHEFAAGVLNVDTGVEVTTDSLFQIGSVSKVWTATQIML 70 Query 125 LVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVAL 184 LVERG++ LD+PV + +P+F VAD + TVT+R LL+HT+G DG D GRGDD + Sbjct 71 LVERGELTLDTPVVQVLPEFRVADPEVTKTVTIRHLLSHTSGIDGDFFLDTGRGDDCIEK 130 Query 185 YVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYF 244 YV+A L Q P G +Y N+G +AGR+IE + G +++ ++ +++PL L HT Sbjct 131 YVEACADLAQNHPIGATQSYCNAGFTIAGRVIERLTGKVWDAALREQIIEPLGLTHTHTL 190 Query 245 SDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAP 304 + ++ A H +DG P V W RSC P G + + D + +A+ HLG G Sbjct 191 PEDVLRFRGAMGH--MDGAPAPV---WGLMRSCGPAGLICARPADVVAFARAHLGTGLLA 245 Query 305 NGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGF 364 + + Q NP G W G+ W+L + I+ HGG GQ + Sbjct 246 DPRVMWEPQ---VDIPNPHTLGKQW------GLGWILD-EWQGRRIISHGGNTIGQAAML 295 Query 365 VMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYE-- 422 VPD + VL N G H F A + F L L A P LG D P+E Sbjct 296 WAVPDTGTVVCVLAN---GGH--TAAFQHALATELFDELLGL-AVPPVLGPPD-EPFETD 348 Query 423 -GRYIAKQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLD 481 RY + TV RDG+L+ A LA +P D Sbjct 349 VERYAGVYERAGSRMTLTV-----RDGRLS-----------LYGEATGALAGVQPPMEFD 392 Query 482 LGPDNKPTGSRSNFVRGPDGNIAWFCS 508 L P + T FV P+G W + Sbjct 393 LVPVDDVT-----FVGRPEGEPQWLSA 414 >gi|326331741|ref|ZP_08198029.1| beta-lactamase [Nocardioidaceae bacterium Broad-1] gi|325950540|gb|EGD42592.1| beta-lactamase [Nocardioidaceae bacterium Broad-1] Length=464 Score = 184 bits (466), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 117/331 (36%), Positives = 174/331 (53%), Gaps = 17/331 (5%) Query 68 MKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVE 127 +K +P AV V GQ +G+ N+D + D++F++GS TK +T ++M+LV+ Sbjct 20 LKRRRVPAAAVGVLHDGQVVDHAHGILNLDTGVEATTDSLFQVGSITKLWTTDLVMQLVD 79 Query 128 RGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVK 187 G + LD + R++P F VADE A+ T+TVRQLL HTAG++G D G GDDAV +V Sbjct 80 EGGIGLDDEIVRHLPTFRVADEEAARTITVRQLLAHTAGFEGDVFTDHGPGDDAVERFVT 139 Query 188 AMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQ 247 +M LPQ+ PG F+Y N+G V GR++E++ GTT++ +Q L PL L H Sbjct 140 SMGDLPQIFAPGERFSYCNAGFAVLGRLVEVLRGTTWDRALQEHLAAPLGLTHLATTPYD 199 Query 248 IIGLNVAASHSVVDGKPIAVTD---FWTFPRSCNPTGGLMST-ARDQLRYAQFHLGDGRA 303 I A H +D P V W R+ P G ++S RD L +A HL G A Sbjct 200 AIRFRTAMGH--IDPGPEHVLRPGPSWGMARASGPVGAMLSMRVRDLLGFAAMHLAGGLA 257 Query 304 PNGEQILSRQS----LKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKG 359 +G +++S S L +P + G G+ W L + + IV H G G Sbjct 258 ADGTRVVSAASCADVLTRQVDHPAS-----TRSDGRGLGWCLDDTRQG--IVGHDGQTIG 310 Query 360 QRSGFVMVPDRNFAMTVLTNSDGGFHMINDL 390 Q + F MVP+ A+ +LTN + + +D+ Sbjct 311 QSAFFRMVPEHGLAVALLTNGGDTYGLYHDV 341 >gi|117164514|emb|CAJ88060.1| putative cmcPBP [Streptomyces ambofaciens ATCC 23877] Length=484 Score = 181 bits (460), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 123/372 (34%), Positives = 190/372 (52%), Gaps = 15/372 (4%) Query 62 AKINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTV 121 A+++ + +PG ++AV G + GV + + D+VF++GS K +T T+ Sbjct 36 ARLDQLCSQHHVPGASLAVLVDGTVHEWASGVLHRGTNVETTTDSVFQMGSIAKIYTATL 95 Query 122 MMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDA 181 +M+L+E G++DLD+PV +PDF++ D A+A ++ R+LL+HT+G D GRGDD Sbjct 96 VMQLIESGRLDLDAPVTDVLPDFSIGDPGATAMISTRRLLSHTSGLTCDFNHDSGRGDDC 155 Query 182 VALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHT 241 +A YV+A + PPG+A +Y++ G V GRI+E+V G T+++ ++ LLL PL L HT Sbjct 156 LAKYVEATKDVALDCPPGSAISYSSVGYNVLGRIVEVVTGKTWDAALKDLLLTPLGLTHT 215 Query 242 RYFSDQIIGLNVAASHSVVDGKPIAVTDFW-TFPRSCNPTGGLMSTARDQLRYAQFHLGD 300 ++ + A H G+ A W PRS P G +++TA D R A+ HL Sbjct 216 MTLPEEALRFRAAMGHLGEPGQEPAPAPEWDMMPRSAGPYGRVIATAGDLARLARMHLAG 275 Query 301 GRAPNGEQILSRQSLKAMRSNPGAGGTLW-VELTGMGVTWMLRPSAENVTIVEHGGTWKG 359 G A +G ++LS ++ M+ W V G G+ W L V H G G Sbjct 276 GVAEDGTRVLSEAAVALMQRREVDCPDKWTVSSDGWGLGWTLY-DWNGVKGYGHDGASIG 334 Query 360 QRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLP------ATPQRL 413 Q +VP A+ +LTN G + L+ L AG++ +P ATP Sbjct 335 QYGYLRVVPSAGVAVALLTNGGGAREVYAALYRE--LLADLAGVA-MPEPFAPSATPP-- 389 Query 414 GAVDLAPYEGRY 425 VD P G Y Sbjct 390 -VVDWGPLVGTY 400 >gi|226304510|ref|YP_002764468.1| S9 family peptidase [Rhodococcus erythropolis PR4] gi|226183625|dbj|BAH31729.1| putative S9 family peptidase [Rhodococcus erythropolis PR4] Length=1122 Score = 181 bits (458), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 127/410 (31%), Positives = 204/410 (50%), Gaps = 15/410 (3%) Query 42 TAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVW---AGGQEYVK---GYGVTN 95 +A + A+ A D ++ + Y + G + + G+E + GV N Sbjct 651 SAKLPKTGLANASAGADAWKRSLDVLCERYGVTGAQFGILTLDSSGKEITRTTVASGVIN 710 Query 96 VDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATV 155 D + V D++F+IGS TK +T ++M+LV+ G +DLD+ VR +PDFA+ DE +A + Sbjct 711 ADTGVEVSTDSLFQIGSITKVWTAMLVMQLVDEGLLDLDATVRSILPDFALQDEETAARI 770 Query 156 TVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRI 215 TVR LLNH G DG D GRGDD V YV+ + Q+ P FAY+NS V+A RI Sbjct 771 TVRALLNHRNGIDGDLFIDKGRGDDVVERYVEGLRDFRQVHPLEDGFAYSNSAYVLAARI 830 Query 216 IELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPR 275 +E++ G ++ ++ ++DPL LAHT + +VAA H+ G + V W R Sbjct 831 VEVLRGGIWDDILKERIIDPLGLAHTLTLTGDTPRYSVAAGHT---GNSV-VMPVWPITR 886 Query 276 SCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGM 335 S P G + ++ D L +A+ L +G++ +G +I+S +S AMR+ L+ + +G Sbjct 887 SMGPAGCITASIGDLLTFAELGLLEGQSVDGVRIVSEKSAAAMRTPEIDISELFPDKSGW 946 Query 336 GVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDW 395 G+ W + I H G+ GQ + + P N A+ +LT+ + DLF Sbjct 947 GLGW-FHETWSGEEIFGHDGSTIGQHAYLRIFPRHNVAIALLTSGGKADGLYRDLFTEAA 1005 Query 396 A----LQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVI 441 A L+ L+ PA+ + + L Y IA + + + VI Sbjct 1006 AALVGLEPPQALAPNPASVESIPDSVLGKYSSGGIAIEFRRGESADEAVI 1055 >gi|229494573|ref|ZP_04388336.1| beta-lactamase family protein/peptidase S9 domain protein [Rhodococcus erythropolis SK121] gi|229318935|gb|EEN84793.1| beta-lactamase family protein/peptidase S9 domain protein [Rhodococcus erythropolis SK121] Length=1122 Score = 181 bits (458), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 127/410 (31%), Positives = 204/410 (50%), Gaps = 15/410 (3%) Query 42 TAVVETVNCADPGAAFDELDAKINAGMKAYAIPGVAVAVW---AGGQEYVK---GYGVTN 95 +A + A+ A D ++ + Y + G + + G+E + GV N Sbjct 651 SAKLPKTGLANASAGADAWKRSLDVLCERYGVTGAQFGILTLDSNGKEITRTTVASGVIN 710 Query 96 VDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATV 155 D + V D++F+IGS TK +T ++M+LV+ G +DLD+ VR +PDFA+ DE +A + Sbjct 711 ADTGVEVSTDSLFQIGSITKVWTAMLVMQLVDEGLLDLDATVRSILPDFALQDEETAARI 770 Query 156 TVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRI 215 TVR LLNH G DG D GRGDD V YV+ + Q+ P FAY+NS V+A RI Sbjct 771 TVRALLNHRNGIDGDLFIDKGRGDDVVERYVEGLRDFRQVHPLEDGFAYSNSAYVLAARI 830 Query 216 IELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPR 275 +E++ G ++ ++ ++DPL LAHT + +VAA H+ G + V W R Sbjct 831 VEVLRGGIWDDILKERIIDPLGLAHTLTLTGDTPRYSVAAGHT---GNSV-VMPVWPITR 886 Query 276 SCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGM 335 S P G + ++ D L +A+ L +G++ +G +I+S +S AMR+ L+ + +G Sbjct 887 SMGPAGCITASIGDLLTFAELGLLEGQSVDGVRIVSEKSAAAMRTPEIDISELFPDKSGW 946 Query 336 GVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDW 395 G+ W + I H G+ GQ + + P N A+ +LT+ + DLF Sbjct 947 GLGW-FHETWSGEEIFGHDGSTIGQHAYLRIFPRHNVAIALLTSGGKADGLYRDLFTEAA 1005 Query 396 A----LQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVI 441 A L+ L+ PA+ + + L Y IA + + + VI Sbjct 1006 AALVGLEPPQALAPNPASVESIPDSVLGKYSSGGIAIEFRRGESADEAVI 1055 >gi|284032800|ref|YP_003382731.1| beta-lactamase [Kribbella flavida DSM 17836] gi|283812093|gb|ADB33932.1| beta-lactamase [Kribbella flavida DSM 17836] Length=1117 Score = 179 bits (454), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 112/358 (32%), Positives = 182/358 (51%), Gaps = 10/358 (2%) Query 92 GVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESA 151 GV N D +PV D++F+IGS TK +T T+ ++LV+ G ++LD+P+ +P+ A+ + Sbjct 700 GVLNKDTGVPVTTDSLFQIGSMTKVWTATLALQLVDEGLLELDAPIADVLPELALRNPDV 759 Query 152 SATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVV 211 + VT+R LL HT+G DG D GRGDD + YV + + Q P G ++Y NSG + Sbjct 760 AKQVTMRHLLTHTSGIDGDVFTDTGRGDDCLEKYVDLLAEVDQNHPLGATWSYCNSGFSL 819 Query 212 AGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFW 271 AGR+IE + G +++ ++ L PL+L HT ++ + A H G+ + W Sbjct 820 AGRVIEKLTGGSWDQALRDRLYKPLKLEHTVTLPEEALLYRAAVGHVGEPGQEPSRAPVW 879 Query 272 TFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVE 331 PR+ P G + STA D L +A+ HL G A +G ++LS +S+ AM + Sbjct 880 GLPRALGPAGLVTSTAADALAFARMHLTGGLAADGTRVLSEESVAAMADKHADLPDKYSL 939 Query 332 LTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLF 391 G+ W +R + ++ H G GQ + ++P++ A+T+LTN + DL+ Sbjct 940 GDSWGLGW-IRFGWDGHRLIGHDGNTIGQAAFLRVLPEQGLAVTLLTNGGNARDLYEDLY 998 Query 392 ASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIAKQVAQNGDLETTVIDFRARDGQ 449 +A + A P VD+ + GRY D + + + RDGQ Sbjct 999 REIFAELADVAMPRPLAPPAESVEVDVHRHVGRY---------DRASVLGEVFVRDGQ 1047 >gi|548461|sp|Q06317.1|PBP4_NOCLA RecName: Full=Penicillin-binding protein 4; Short=PBP-4 gi|44999|emb|CAA78374.1| cmcPBP [Amycolatopsis lactamdurans] Length=381 Score = 179 bits (453), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 124/369 (34%), Positives = 185/369 (51%), Gaps = 11/369 (2%) Query 63 KINAGMKAYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVM 122 + +A + +PG A+AV+ G + GV + + V D+VF+ GS K +T T++ Sbjct 11 RFDALRTEHHVPGAALAVFVDGDLHELASGVLHRGTGVAVTTDSVFQSGSVAKVYTATLV 70 Query 123 MRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAV 182 M+LV+ G++ LD+ V +P FAVAD + TVT+ +LL+HT+G G D GRGDD + Sbjct 71 MQLVDAGELRLDTRVADVLPGFAVADAEVARTVTIGRLLSHTSGIAGDFTLDTGRGDDCL 130 Query 183 ALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTR 242 A +V A + Q PP T +Y ++G + GRI+E++ G +++ ++ L PL L + Sbjct 131 ARFVDACADVGQDCPPDTVISYCSTGYAILGRIVEVLTGQSWDDALRDRLFTPLGLHQSM 190 Query 243 YFSDQIIGLNVAASH---SVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLG 299 ++ + VA SH D +P V D PRS P G ++ TA D +R+A+ HL Sbjct 191 TLPEEALRFRVAMSHLGELGTDPEPAPVWDM--LPRSAGPYGRVLITAADVVRFARMHLD 248 Query 300 DGRAPNGEQILSRQSLKAMRSNPGAGGTLWVEL-TGMGVTWMLRPSAENVTIVEHGGTWK 358 DG AP+G ++LS S MR W + TG G W L + V H G Sbjct 249 DGVAPDGTRVLSAASAALMRQQVAGCLDTWSFMATGWGHGWALY-DWDGVPGYGHDGASG 307 Query 359 GQRSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAG--LSNLPATPQRLGAV 416 GQ S +VP +LTN DLF L AG + + A P + Sbjct 308 GQFSYLRVVPGSGVVAALLTNGGVATSFFTDLFRE--LLGELAGVRMPEVFAPPAEPRPI 365 Query 417 DLAPYEGRY 425 D+AP G Y Sbjct 366 DVAPLAGTY 374 >gi|291303465|ref|YP_003514743.1| beta-lactamase [Stackebrandtia nassauensis DSM 44728] gi|290572685|gb|ADD45650.1| beta-lactamase [Stackebrandtia nassauensis DSM 44728] Length=460 Score = 178 bits (451), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 101/323 (32%), Positives = 167/323 (52%), Gaps = 3/323 (0%) Query 71 YAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGK 130 + IPG +A+ G+ + G+ N + + V D+VF+ GS K +T T MRLV++G+ Sbjct 21 HRIPGAQLAILVDGEIHELASGILNKNTGVAVTTDSVFQSGSVAKVYTATAAMRLVDQGR 80 Query 131 VDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMT 190 +DLD+ V +P+F D A+A +TVR L H +G + RGDD + L+V+ Sbjct 81 LDLDAKVVDVLPEFGTPDAEATARITVRHLFCHLSGTGSEFHGNPNRGDDCIELFVRDAR 140 Query 191 RLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIG 250 +P PPG A +Y+N G++ RI+E++ G ++ +++LL +PL L + ++ + Sbjct 141 EVPMDLPPGVAASYSNIGIITLARIVEVITGEVWDDALKQLLFEPLGLKRSFTLTEDAVR 200 Query 251 LNVAASHSVVDGKPIAVTDFWTF-PRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQI 309 NVA H G + WT PR+ +P ++ +A D R+A+ HL G +G +I Sbjct 201 YNVAMGHLGAPGAEPEPAEMWTVHPRAASPAAHILMSAGDMARFAKLHLDGGVTADGTRI 260 Query 310 LSRQSLKAMRSNPGAGGTLW-VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVP 368 +S +S+ AMR W V G+ W L N H G+ Q + + P Sbjct 261 MSAESVAAMREPQSVPVDRWSVSADAWGLGWSLY-DHPNYHGFGHDGSAVSQHAMLRIYP 319 Query 369 DRNFAMTVLTNSDGGFHMINDLF 391 ++ A+ ++TNS G + DLF Sbjct 320 EQGVALALMTNSGAGRSLYADLF 342 >gi|226308610|ref|YP_002768570.1| penicillin-binding protein [Rhodococcus erythropolis PR4] gi|226187727|dbj|BAH35831.1| putative penicillin-binding protein [Rhodococcus erythropolis PR4] Length=471 Score = 178 bits (451), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 116/343 (34%), Positives = 173/343 (51%), Gaps = 17/343 (4%) Query 57 FDELDAKINAGMKAYAIPGVAVAVWAGGQE-----YVKGYGVTNVDHPMPVDGDTVFRIG 111 DEL AK +++PG V V A G++ V GVT+++ + VD DT+F+ G Sbjct 25 LDELAAK-------HSVPGAQVGVIALGEDGAADIRVITTGVTSLNTRVDVDADTLFQYG 77 Query 112 STTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRN 171 S +K +T T++M+LV+ GK+ LD+ V +P+F +AD S + +T+RQLL HT+G DG Sbjct 78 SASKIWTTTLIMQLVDEGKLTLDTLVVEVLPEFTIADPSNTKEITIRQLLTHTSGIDGDL 137 Query 172 GQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRL 231 D G GDD V YV + +T PG +Y+N+G VAGRI+E++ T++ + Sbjct 138 FNDTGDGDDCVEKYVDELATAISVTEPGGHLSYSNAGFAVAGRIVEVLREMTWDEALVEY 197 Query 232 LLDPLQLAHTRYFSDQIIGLNVAASHSV----VDGKPIAVTDFWTFPRSCNPTGGLMSTA 287 L PL L H + A H + T W PR P G + + Sbjct 198 LWKPLGLTHIITKAKDAPLFRTAVGHVANPDRTSPDKVVPTKQWLLPRGIGPAGIITGSV 257 Query 288 RDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAEN 347 L + H+ DG A GE+ILS +S + MR+ + G+ W+L Sbjct 258 SSLLTFGAAHMRDGLALTGERILSEESARLMRTPQFDLTAVSSVDQAWGLGWILSDWG-G 316 Query 348 VTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDL 390 VT +HGG GQ + F P+ AM V+TNS GG + +D+ Sbjct 317 VTSAQHGGATIGQITRFHTFPELGLAMAVVTNSRGGGALAHDI 359 >gi|229488910|ref|ZP_04382776.1| beta-lactamase [Rhodococcus erythropolis SK121] gi|229324414|gb|EEN90169.1| beta-lactamase [Rhodococcus erythropolis SK121] Length=464 Score = 178 bits (451), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 116/343 (34%), Positives = 173/343 (51%), Gaps = 17/343 (4%) Query 57 FDELDAKINAGMKAYAIPGVAVAVWAGGQE-----YVKGYGVTNVDHPMPVDGDTVFRIG 111 DEL AK +++PG V V A G++ V GVT+++ + VD DT+F+ G Sbjct 18 LDELAAK-------HSVPGAQVGVIALGEDGAADIRVITTGVTSLNTRVDVDADTLFQYG 70 Query 112 STTKTFTGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRN 171 S +K +T T++M+LV+ GK+ LD+ V +P+F +AD S + +T+RQLL HT+G DG Sbjct 71 SASKIWTTTLIMQLVDEGKLTLDTLVVEVLPEFTIADPSNTKEITIRQLLTHTSGIDGDL 130 Query 172 GQDFGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRL 231 D G GDD V YV + +T PG +Y+N+G VAGRI+E++ T++ + Sbjct 131 FNDTGDGDDCVEKYVDELATAISVTEPGGHLSYSNAGFAVAGRIVEVLREMTWDEALVEY 190 Query 232 LLDPLQLAHTRYFSDQIIGLNVAASHSV----VDGKPIAVTDFWTFPRSCNPTGGLMSTA 287 L PL L H + A H + T W PR P G + + Sbjct 191 LWKPLGLTHIITKAKDAPLFRTAVGHVANPDRTSPDKVIPTKQWLLPRGIGPAGIITGSV 250 Query 288 RDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAEN 347 L + H+ DG A GE+ILS +S + MR+ + G+ W+L Sbjct 251 SSLLTFGAAHMRDGLALTGERILSEESARLMRTPQFDLTAVSSVDQAWGLGWILSDWG-G 309 Query 348 VTIVEHGGTWKGQRSGFVMVPDRNFAMTVLTNSDGGFHMINDL 390 VT +HGG GQ + F P+ AM V+TNS GG + +D+ Sbjct 310 VTSAQHGGATIGQITRFHTFPELGLAMAVVTNSRGGGALAHDI 352 >gi|291303063|ref|YP_003514341.1| beta-lactamase [Stackebrandtia nassauensis DSM 44728] gi|290572283|gb|ADD45248.1| beta-lactamase [Stackebrandtia nassauensis DSM 44728] Length=456 Score = 176 bits (445), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 111/326 (35%), Positives = 177/326 (55%), Gaps = 8/326 (2%) Query 71 YAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGK 130 + IPG ++A+ GQ + GV N D + V D++F+ GS K +T TV+MRLV GK Sbjct 20 HRIPGASLAILVDGQIHELASGVLNRDTGVEVTPDSLFQSGSVAKIYTATVIMRLVGEGK 79 Query 131 VDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAG-WDGRNGQDFGRGDDAVALYVKAM 189 +DLD+ V +P+F+ D A+A +T+RQLL+HT G + +G G DA+A YV+A Sbjct 80 LDLDAKVVDVLPEFSTPDPEAAAQITIRQLLSHTGGVTNDFHGAADATGGDALARYVEAA 139 Query 190 TRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQII 249 +P PPGTA +Y + G+VV GR+IE++ GTT+ ++ LL DPL L + ++ + Sbjct 140 REVPLDLPPGTAASYGSLGIVVLGRVIEVLTGTTWNQALKDLLFDPLGLKRSVTLPEEAM 199 Query 250 GLNVAASHSVVDG-KPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQ 308 A H G P + F PR+ P ++ +A D +R A+ HL G AP+G + Sbjct 200 RYRYAWGHLGQPGTDPEPIDMFSYIPRAFAPAAQVLVSAGDLVRLAKLHLDGGVAPDGTR 259 Query 309 ILSRQSLKAMRSNPGAGGTLW-VELTGMGVTWML--RPSAENVTIVEHGGTWKGQRSGFV 365 I++ +++ AM+ W V G+ W L +P + H G+ Q + Sbjct 260 IVAAEAVAAMQRVESTPVDRWSVSADHWGLGWCLYDQPGFQGFG---HDGSAVSQHAMLR 316 Query 366 MVPDRNFAMTVLTNSDGGFHMINDLF 391 + P++ A+ ++TNS G + +LF Sbjct 317 VFPEQGVALALMTNSGNGRSLYAELF 342 >gi|284030432|ref|YP_003380363.1| beta-lactamase [Kribbella flavida DSM 17836] gi|283809725|gb|ADB31564.1| beta-lactamase [Kribbella flavida DSM 17836] Length=437 Score = 175 bits (443), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 130/396 (33%), Positives = 193/396 (49%), Gaps = 43/396 (10%) Query 71 YAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGK 130 Y +PG + +WA GQ+ V YGV N + V D+VF+IGS +K +T T++++L + Sbjct 15 YDVPGAVLGIWADGQQTVAPYGVLNRATGVEVTADSVFQIGSVSKPWTATMIVQLAAEQR 74 Query 131 VDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMT 190 + LD PV +P+ ++ +TVRQLL H +G DG D GRGDD V YV + Sbjct 75 LSLDDPVLSLLPEASI-----DPRITVRQLLTHGSGIDGDVFTDTGRGDDCVERYVGLLA 129 Query 191 RLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIG 250 + QL PGTA++Y N+G V+ GRI+E++ G T++ +++ L++PL L T ++ I Sbjct 130 DVDQLFEPGTAYSYCNAGFVLLGRIVEVLDGRTWDESLRARLVEPLGLKSTVTLPEEAIL 189 Query 251 LNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQIL 310 A H DG P+ W PRS P G + +A D L +A+ HL D R + Sbjct 190 HRAAVGHLAGDGTPVTT---WQLPRSIGPAGLITQSAGDLLAFARLHLDDDRYAGMRE-- 244 Query 311 SRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMVPDR 370 S PG G LT +G+TW L T+ H G Q + + P+ Sbjct 245 ------PQVSYPGGGVG---GLTEIGLTWRLY-DWSGRTLFGHDGMTISQLAFLRIDPEA 294 Query 371 NFAMTVLTNSDGGFHMINDLFASDWALQRFAGLS--NLPATPQ------------RLGAV 416 N A +LTNS + L A + F L+ +PA PQ G Sbjct 295 NVAFCLLTNSGNAPALFEAL-----ATEVFTALTGVGVPAGPQPDDDPGERIDGELWGER 349 Query 417 DLAPYEGRYIAKQVA-QNGDLETTVIDFRARDGQLA 451 L YE +A +V ++G L V+ F+A +LA Sbjct 350 HLGRYERESVAMEVLRRDGKL---VLTFQATGDRLA 382 >gi|290959971|ref|YP_003491153.1| beta-lactamase [Streptomyces scabiei 87.22] gi|260649497|emb|CBG72612.1| putative beta-lactamase [Streptomyces scabiei 87.22] Length=480 Score = 174 bits (442), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 131/417 (32%), Positives = 198/417 (48%), Gaps = 28/417 (6%) Query 70 AYAIPGVAVAVWAGGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERG 129 A+ +PG +A A G+ + GV + + D+VF++GS K +T ++M+LVE G Sbjct 45 AHGVPGATLAFLAHGEIHELASGVLSTATGVEATTDSVFQLGSIAKVYTAALVMQLVESG 104 Query 130 KVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAM 189 ++DLD PV + +P+FA D +A+ +T R LL+HT+G D GRGDDA+A YV+A Sbjct 105 ELDLDVPVVKVLPEFATVDPAATEVITPRMLLSHTSGLTCDFHIDTGRGDDAIARYVEAA 164 Query 190 TRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQII 249 + PPGTA +Y+ G VV GRI+E++ G T++ ++ + PL LAHT ++ + Sbjct 165 KGVAMDCPPGTAVSYSGIGYVVLGRIVEVLTGLTWDQALRERVFAPLGLAHTMTLPEEAL 224 Query 250 GLNVAASHSV-VDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNGEQ 308 VA H DG + PR+ P +++TA D +RYA+ HL DG G Sbjct 225 PFRVAMGHMAGEDGTQTPAPAWDLMPRAAGPGARVLATAGDVVRYAKAHL-DG----GAG 279 Query 309 ILSRQSLKAMRSNPGAGGTLW-VELTGMGVTWMLRPSAENVTIVEHGGTWKGQRSGFVMV 367 IL +++ AM++ W V G G+ W L + V H G GQ + + Sbjct 280 ILRPETVSAMQARETDVPDKWTVSADGWGLGWTLY-DWDGVPGHGHDGAATGQYAFLRVA 338 Query 368 PDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNLPATPQRLGAVDLAPYEGRYIA 427 P + A+ +LTN + DL A + A AVD+ P+ G Y Sbjct 339 PTKGVAVALLTNGGASRLLYADLLRELMAEPAGVTMPAPFAPAAEPPAVDITPWTGTY-- 396 Query 428 KQVAQNGDLETTVIDFRARDGQLAGSMSTDDANPDGQNSANLGLAFYRPDYGLDLGP 484 E VI R+G P + G+ Y PD +DL P Sbjct 397 -------KREGVVITIGERNG-----------TPHLTYAFVDGMVGYSPDLEMDLVP 435 >gi|302530195|ref|ZP_07282537.1| predicted protein [Streptomyces sp. AA4] gi|302439090|gb|EFL10906.1| predicted protein [Streptomyces sp. AA4] Length=1102 Score = 174 bits (441), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 118/373 (32%), Positives = 188/373 (51%), Gaps = 31/373 (8%) Query 69 KAYAIPGVAVAVWA--GGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLV 126 + Y IPG ++ + G+E +GV + + V D++F+IGS +K +T TV+M+LV Sbjct 662 RKYDIPGASLGILRVDTGEEVFATHGVLSKTTEVEVTEDSLFQIGSISKVWTSTVVMQLV 721 Query 127 ERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYV 186 + G +DLD+P+ +P+ ++D + VT+R LL HT+G DG D GRGDD + +V Sbjct 722 DEGLLDLDAPIVDVLPELRLSDPEVTKRVTMRHLLTHTSGIDGDIFTDTGRGDDCIEKFV 781 Query 187 KAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSD 246 + + Q P G F+Y NSG V+ GR+IE + G T+++ ++ L PL L HT + Sbjct 782 ELLDEAAQNHPLGATFSYCNSGFVLMGRVIEKLTGKTWDAAMREKLYTPLGLTHTVTLPE 841 Query 247 QIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGLMSTARDQLRYAQFHLGDGRAPNG 306 + + A H DG+ A W PRS P G + + A D L +A+ HL G +G Sbjct 842 EALLFRAAVGHVAPDGEDPAPAPVWQLPRSAGPAGLISARAADVLAFARLHLTGGLTADG 901 Query 307 EQILSRQSL------KAMRSNPGAGGTLWVELTGMGVTWMLRPSAENVTIVEHGGTWKGQ 360 +ILS +S +A + G W G+ W +R ++ H G GQ Sbjct 902 TRILSAESAAAMAEKQADVPDKHTLGDSW------GLGW-IRDEWGGRRVIGHDGNTIGQ 954 Query 361 RSGFVMVPDRNFAMTVLTNSDGGFHMINDLFASDWALQRFAGLSNL--------PATPQR 412 + ++PD A+T+LTN + +L+ + FA L+++ PATP Sbjct 955 SAFLRLLPDAGLAVTLLTNGGHARDLFTELYR-----EIFAELADVAMPRPLEPPATPVE 1009 Query 413 LGAVDLAPYEGRY 425 VD+ + G Y Sbjct 1010 ---VDVTRHLGVY 1019 >gi|300785357|ref|YP_003765648.1| beta-lactamase class C [Amycolatopsis mediterranei U32] gi|299794871|gb|ADJ45246.1| beta-lactamase class C [Amycolatopsis mediterranei U32] gi|340526801|gb|AEK42006.1| beta-lactamase class C [Amycolatopsis mediterranei S699] Length=461 Score = 170 bits (431), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 112/308 (37%), Positives = 164/308 (54%), Gaps = 21/308 (6%) Query 83 GGQEYVKGYGVTNVDHPMPVDGDTVFRIGSTTKTFTGTVMMRLVERGKVDLDSPVRRYIP 142 GG+ + GV N + D D++F+IGS TK +T T+ M+LV+ G +DLD PVR+Y+P Sbjct 34 GGEIIDRAAGVLNTGTGVEADVDSLFQIGSITKVWTATLAMQLVDDGVLDLDQPVRKYLP 93 Query 143 DFAVADESASATVTVRQLLNHTAGWDGRNGQDFGRGDDAVALYVKAMTRLPQLTPPGTAF 202 +FA+AD+ A+A +TVRQL+ HTAG++G D GRG D + YV + +PQL PG F Sbjct 94 EFALADDDAAARITVRQLMCHTAGFEGDIFTDTGRGADCIEKYVATLGDVPQLFAPGEMF 153 Query 203 AYNNSGLVVAGRIIELVAGTTYESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSV--- 259 +YNN+ V GR++E++ G TY+ +Q L PL L H + I A H Sbjct 154 SYNNAAFCVLGRLVEVLRGKTYDECLQDHLFTPLGLTHAAPSPYEAIRFRAALGHLTSSP 213 Query 260 -VDGKPIAVTDFWTFPRSCNPTGGLMST-ARDQLRYAQFHLGDGRAPNGEQILSRQSLKA 317 D +P + W S P G +++ RD + +A HL DG +G ++L S +A Sbjct 214 GADPEPAGI---WALTPSNAPAGSMLAMRPRDLVTFAAMHLKDGEGADGTRVLGADSARA 270 Query 318 MRSNPGAGGTLWVELTGMGV---TWMLRPS---AENVTIVEHGGTWKGQRSGFVMVPDRN 371 MR VEL +G+ W L S A +V H G GQ + + P+ Sbjct 271 MRER-------LVELPDLGIFGDAWGLGWSLFDAPGGKVVGHDGGTIGQSAFLRVAPEHG 323 Query 372 FAMTVLTN 379 A+ +LTN Sbjct 324 VAVALLTN 331 Lambda K H 0.319 0.136 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1128999233308 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40