BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv1820 Length=547 Score E Sequences producing significant alignments: (Bits) Value gi|15608957|ref|NP_216336.1| hypothetical protein Rv1820 [Mycoba... 1094 0.0 gi|340626828|ref|YP_004745280.1| putative acetolactate synthase ... 1092 0.0 gi|167968088|ref|ZP_02550365.1| hypothetical protein MtubH3_0864... 1082 0.0 gi|240171743|ref|ZP_04750402.1| hypothetical protein MkanA1_2068... 962 0.0 gi|183982704|ref|YP_001850995.1| acetolactate synthase IlvG [Myc... 949 0.0 gi|118618428|ref|YP_906760.1| hypothetical protein MUL_3039 [Myc... 946 0.0 gi|15828126|ref|NP_302389.1| hypothetical protein ML2083 [Mycoba... 927 0.0 gi|296164806|ref|ZP_06847365.1| acetolactate synthase [Mycobacte... 920 0.0 gi|342861276|ref|ZP_08717924.1| hypothetical protein MCOL_20431 ... 910 0.0 gi|306776039|ref|ZP_07414376.1| acetolactate synthase ilvG [Myco... 901 0.0 gi|118462562|ref|YP_882081.1| hypothetical protein MAV_2895 [Myc... 900 0.0 gi|254823247|ref|ZP_05228248.1| hypothetical protein MintA_25179... 897 0.0 gi|254775371|ref|ZP_05216887.1| hypothetical protein MaviaA2_119... 886 0.0 gi|289443294|ref|ZP_06433038.1| conserved hypothetical protein [... 843 0.0 gi|284046651|ref|YP_003396991.1| thiamine pyrophosphate protein ... 713 0.0 gi|41407631|ref|NP_960467.1| hypothetical protein MAP1533 [Mycob... 553 2e-155 gi|336457583|gb|EGO36588.1| thiamine pyrophosphate-dependent enz... 551 1e-154 gi|315502304|ref|YP_004081191.1| thiamine pyrophosphate tpp-bind... 498 1e-138 gi|302865748|ref|YP_003834385.1| thiamine pyrophosphate TPP-bind... 497 2e-138 gi|296270873|ref|YP_003653505.1| thiamine pyrophosphate protein ... 497 3e-138 gi|330466174|ref|YP_004403917.1| hypothetical protein VAB18032_1... 493 4e-137 gi|271969508|ref|YP_003343704.1| acetolactate synthase [Streptos... 490 2e-136 gi|145593758|ref|YP_001158055.1| hypothetical protein Strop_1207... 473 3e-131 gi|238063176|ref|ZP_04607885.1| thiamine pyrophosphate protein d... 473 4e-131 gi|159036746|ref|YP_001535999.1| hypothetical protein Sare_1100 ... 473 5e-131 gi|256396829|ref|YP_003118393.1| hypothetical protein Caci_7728 ... 464 2e-128 gi|311743932|ref|ZP_07717738.1| acetolactate synthase [Aeromicro... 459 6e-127 gi|119715945|ref|YP_922910.1| hypothetical protein Noca_1710 [No... 459 7e-127 gi|72160957|ref|YP_288614.1| hypothetical protein Tfu_0553 [Ther... 456 4e-126 gi|319950475|ref|ZP_08024388.1| hypothetical protein ES5_12867 [... 454 2e-125 gi|116747745|ref|YP_844432.1| thiamine pyrophosphate binding dom... 376 7e-102 gi|297563047|ref|YP_003682021.1| thiamine pyrophosphate TPP bind... 372 8e-101 gi|302557242|ref|ZP_07309584.1| TPP requiring enzyme [Streptomyc... 361 2e-97 gi|302555346|ref|ZP_07307688.1| acetolactate synthase, large sub... 360 3e-97 gi|297190798|ref|ZP_06908196.1| TPP-requiring enzyme [Streptomyc... 360 4e-97 gi|291436090|ref|ZP_06575480.1| TPP-requiring enzyme [Streptomyc... 358 1e-96 gi|284030091|ref|YP_003380022.1| thiamine pyrophosphate protein ... 358 1e-96 gi|300786452|ref|YP_003766743.1| acetolactate synthase I/II/III ... 356 6e-96 gi|21224884|ref|NP_630663.1| TPP-requiring enzyme [Streptomyces ... 356 7e-96 gi|297156123|gb|ADI05835.1| putative TPP-requiring protein [Stre... 354 3e-95 gi|302541482|ref|ZP_07293824.1| TPP requiring enzyme [Streptomyc... 352 1e-94 gi|345010283|ref|YP_004812637.1| thiamine pyrophosphate TPP-bind... 351 2e-94 gi|340527930|gb|AEK43135.1| acetolactate synthase I/II/III large... 351 2e-94 gi|290956176|ref|YP_003487358.1| TPP-requiring protein [Streptom... 348 1e-93 gi|153003956|ref|YP_001378281.1| thiamine pyrophosphate protein ... 348 1e-93 gi|162456410|ref|YP_001618777.1| acetolactate synthase [Sorangiu... 348 1e-93 gi|29828361|ref|NP_822995.1| TPP-requiring enzyme (acetolactate ... 347 3e-93 gi|313902460|ref|ZP_07835862.1| thiamine pyrophosphate TPP-bindi... 343 3e-92 gi|317122179|ref|YP_004102182.1| thiamine pyrophosphate TPP-bind... 342 9e-92 gi|41407630|ref|NP_960466.1| hypothetical protein MAP1532 [Mycob... 333 3e-89 >gi|15608957|ref|NP_216336.1| hypothetical protein Rv1820 [Mycobacterium tuberculosis H37Rv] gi|15841290|ref|NP_336327.1| hypothetical protein MT1868 [Mycobacterium tuberculosis CDC1551] gi|31793010|ref|NP_855503.1| hypothetical protein Mb1851 [Mycobacterium bovis AF2122/97] 73 more sequence titles Length=547 Score = 1094 bits (2829), Expect = 0.0, Method: Compositional matrix adjust. Identities = 547/547 (100%), Positives = 547/547 (100%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA Sbjct 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ Sbjct 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG Sbjct 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV Sbjct 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR Sbjct 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR Sbjct 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY Sbjct 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY Sbjct 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY Sbjct 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 Query 541 PRRSNLA 547 PRRSNLA Sbjct 541 PRRSNLA 547 >gi|340626828|ref|YP_004745280.1| putative acetolactate synthase ilvG [Mycobacterium canettii CIPT 140010059] gi|340005018|emb|CCC44167.1| putative acetolactate synthase ilvG (acetohydroxy-acid synthase)(ALS) [Mycobacterium canettii CIPT 140010059] Length=547 Score = 1092 bits (2825), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/547 (99%), Positives = 546/547 (99%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA Sbjct 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ Sbjct 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG Sbjct 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGALTELPAGPTPAGDALDRA GLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV Sbjct 181 RPGALTELPAGPTPAGDALDRAVGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR Sbjct 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR Sbjct 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY Sbjct 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY Sbjct 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY Sbjct 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 Query 541 PRRSNLA 547 PRRSNLA Sbjct 541 PRRSNLA 547 >gi|167968088|ref|ZP_02550365.1| hypothetical protein MtubH3_08645 [Mycobacterium tuberculosis H37Ra] Length=548 Score = 1082 bits (2798), Expect = 0.0, Method: Compositional matrix adjust. Identities = 544/548 (99%), Positives = 544/548 (99%), Gaps = 1/548 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA Sbjct 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ Sbjct 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG Sbjct 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV Sbjct 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR Sbjct 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 Query 301 VEP-AREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDD 359 VEP R PRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDD Sbjct 301 VEPRTRNIPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDD 360 Query 360 RIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPG 419 RIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPG Sbjct 361 RIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPG 420 Query 420 YALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEAL 479 YALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEAL Sbjct 421 YALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEAL 480 Query 480 YGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVA 539 YGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVA Sbjct 481 YGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVA 540 Query 540 YPRRSNLA 547 YPRRSNLA Sbjct 541 YPRRSNLA 548 >gi|240171743|ref|ZP_04750402.1| hypothetical protein MkanA1_20685 [Mycobacterium kansasii ATCC 12478] Length=547 Score = 962 bits (2487), Expect = 0.0, Method: Compositional matrix adjust. Identities = 477/547 (88%), Positives = 503/547 (92%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MS A AQTMHAGRLIARRLKASG+DTVFTLSGGHLFS+YDGCREEGIRLIDTRHEQ+A Sbjct 1 MSAGAAAAQTMHAGRLIARRLKASGVDTVFTLSGGHLFSVYDGCREEGIRLIDTRHEQSA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTRVPGVAALTAGPG+TNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ Sbjct 61 AFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA++AG LVD ALQAAV APSGVAFVDFPMD+ FSMS D+G Sbjct 121 EIDHVPFVAPLARFAATAQSADDAGRLVDDALQAAVGAPSGVAFVDFPMDYVFSMSDDDG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGALT LP P GD LDRAAGLLS A+RPVIMAGTNVWWGHAEAALLRL EER IPV Sbjct 181 RPGALTGLPTAARPDGDVLDRAAGLLSAARRPVIMAGTNVWWGHAEAALLRLAEERRIPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARG VPADH LAFSRARSKALG+ADVALIVGVPMDFRLGFGGVFGS TQL+VADR Sbjct 241 LMNGMARGAVPADHPLAFSRARSKALGQADVALIVGVPMDFRLGFGGVFGSQTQLVVADR 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 EP R HPR VAAGLYGDL+A LSAL G GG DH+ WI+EL TAET RD EK EL ++R Sbjct 301 AEPERGHPRAVAAGLYGDLSAILSALTGPGGADHRDWIDELRTAETAERDAEKVELAEER 360 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 IPLHPMRVYAELA LL+R+A+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSGPGY Sbjct 361 IPLHPMRVYAELAPLLDRNAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCLGSGPGY 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLARP RQVVLLQGDGAFGFSGMEWDTLVRHNV VVS++GNNGIWGLEKHPMEALY Sbjct 421 ALAAKLARPDRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSIVGNNGIWGLEKHPMEALY 480 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEV RALG HGELVS PAELRPAL+RAFASGLP+VVNVLTDP+VAY Sbjct 481 GYSVVAELRPGTRYDEVARALGAHGELVSTPAELRPALQRAFASGLPSVVNVLTDPTVAY 540 Query 541 PRRSNLA 547 PRRSNLA Sbjct 541 PRRSNLA 547 >gi|183982704|ref|YP_001850995.1| acetolactate synthase IlvG [Mycobacterium marinum M] gi|183176030|gb|ACC41140.1| acetolactate synthase IlvG [Mycobacterium marinum M] Length=550 Score = 949 bits (2452), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/550 (86%), Positives = 498/550 (91%), Gaps = 3/550 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTD AP QT+HAGRL+ARRL+ASG+DTVFTLSGGHLFS+YDGCR+EG+RLIDTRHEQ A Sbjct 1 MSTDAAPVQTVHAGRLVARRLRASGVDTVFTLSGGHLFSLYDGCRDEGVRLIDTRHEQAA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTRVPGVAALTAGPG+TNGMSAMAAAQQNQSPLVVLGGRAPA RWGMGSLQ Sbjct 61 AFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPAGRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSAE+AG LVDQAL+AAV + SGVAFVDFPMDH FSM+ D+G Sbjct 121 EIDHVPFVAPLARFAATAQSAEDAGRLVDQALRAAVGSRSGVAFVDFPMDHVFSMAEDDG 180 Query 181 RPGALTELPAG---PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERH 237 RPG LTE PA P P G +DRAA LLS A RPVIMAGTNVWWGH E ALLRL EER Sbjct 181 RPGVLTEQPAAAQHPAPNGREIDRAAELLSRAHRPVIMAGTNVWWGHGERALLRLAEERQ 240 Query 238 IPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIV 297 IPVLMNGMARGVVPADH LAFSRARSKALGEADVALIVGVPMDFRLGFGGVFG TQLIV Sbjct 241 IPVLMNGMARGVVPADHPLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGPQTQLIV 300 Query 298 ADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELV 357 DR EP R+HPRP+AAGLYGDL+ L+AL G DHQ WI EL ET AR+ EK EL Sbjct 301 VDRAEPERQHPRPIAAGLYGDLSQILAALTGPDAGDHQSWIRELRDTETEAREREKTELA 360 Query 358 DDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSG 417 +DRIPLHPMRVYAELA LL+RDA+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSG Sbjct 361 EDRIPLHPMRVYAELAPLLDRDAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCLGSG 420 Query 418 PGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPME 477 PGYALAAKLARP+RQVVLLQGDGAFGFSGMEWDTLVRHNV VVSV+GNNGIWGLEKHPME Sbjct 421 PGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVVGNNGIWGLEKHPME 480 Query 478 ALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPS 537 ALYGYSVVAELRPGTRYDEVVRALGGHGELV+ PA+LRPALERAFASGLPAVVNVLTDPS Sbjct 481 ALYGYSVVAELRPGTRYDEVVRALGGHGELVAAPAQLRPALERAFASGLPAVVNVLTDPS 540 Query 538 VAYPRRSNLA 547 VAYPRRSNLA Sbjct 541 VAYPRRSNLA 550 >gi|118618428|ref|YP_906760.1| hypothetical protein MUL_3039 [Mycobacterium ulcerans Agy99] gi|118570538|gb|ABL05289.1| acetolactate synthase IlvG [Mycobacterium ulcerans Agy99] Length=550 Score = 946 bits (2445), Expect = 0.0, Method: Compositional matrix adjust. Identities = 469/550 (86%), Positives = 497/550 (91%), Gaps = 3/550 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTD P QT+HAGRL+ARRL+ASG+DTVFTLSGGHLFS+YDGCR+EG+RL+DTRHEQTA Sbjct 1 MSTDATPVQTVHAGRLVARRLRASGVDTVFTLSGGHLFSLYDGCRDEGVRLVDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTRVPGVAALTAGPG+TNGMSAMAAAQQNQSPLVVLGGRAPA RWGMGSLQ Sbjct 61 AFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPAGRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ RFAATAQSAE+AGLLVDQAL+AAV + SGVAFVDFPMDH FSM+ D+G Sbjct 121 EIDHVPFVAPLTRFAATAQSAEDAGLLVDQALRAAVGSHSGVAFVDFPMDHVFSMAQDDG 180 Query 181 RPGALTELPAG---PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERH 237 RPG LTE PA P P G +DRAA LLS AQRPVIMAGTNVWWGH E ALLRL EER Sbjct 181 RPGVLTEQPAAAQHPAPNGREIDRAAELLSRAQRPVIMAGTNVWWGHGERALLRLAEERQ 240 Query 238 IPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIV 297 IPVLMNGMARGVVPADH LAFSRARSKALGEADVALIVGVPMDFRLGFGGVFG TQLIV Sbjct 241 IPVLMNGMARGVVPADHPLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGPQTQLIV 300 Query 298 ADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELV 357 DR EP R+HPRP+AAGLYGDL+ L+AL G DHQ WI EL ET AR+ EK EL Sbjct 301 VDRAEPERQHPRPIAAGLYGDLSQILAALTGPDAGDHQSWIRELRDTETEAREREKTELA 360 Query 358 DDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSG 417 +DRIPLHPMRVYAELA LL+RDA+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSG Sbjct 361 EDRIPLHPMRVYAELAPLLDRDAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCLGSG 420 Query 418 PGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPME 477 PG ALAAKLARP+RQVVLLQGDGAFGFSGMEWDTLVRHNV VVSV+GNNGIWGLEKHPME Sbjct 421 PGCALAAKLARPERQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVVGNNGIWGLEKHPME 480 Query 478 ALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPS 537 ALYGYSVVAELRPGTRYDEVVRALGGHGELV+ PAELRPALERAFASGLPAVVNVLTD S Sbjct 481 ALYGYSVVAELRPGTRYDEVVRALGGHGELVAAPAELRPALERAFASGLPAVVNVLTDSS 540 Query 538 VAYPRRSNLA 547 VAYPRRSNLA Sbjct 541 VAYPRRSNLA 550 >gi|15828126|ref|NP_302389.1| hypothetical protein ML2083 [Mycobacterium leprae TN] gi|221230603|ref|YP_002504019.1| hypothetical protein MLBr_02083 [Mycobacterium leprae Br4923] gi|2578387|emb|CAA15478.1| TPP-requiring enzyme [Mycobacterium leprae] gi|13093680|emb|CAC31038.1| acetolactate synthase II [Mycobacterium leprae] gi|219933710|emb|CAR72180.1| acetolactate synthase II [Mycobacterium leprae Br4923] Length=548 Score = 927 bits (2396), Expect = 0.0, Method: Compositional matrix adjust. Identities = 472/548 (87%), Positives = 495/548 (91%), Gaps = 1/548 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTD ++HAGRL+ RRLKASG+DTVFTLSGGHLFSIYDGCR E IRLIDTRHEQTA Sbjct 1 MSTDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGWSKVTR PGVA LTAGPG+TNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ Sbjct 61 AFAAEGWSKVTRQPGVAVLTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSD-N 179 EIDHVPFVAP+ARFAATAQSA+ AG LVD+ALQAAV APSGV FVDFPMD+ FSM+ D Sbjct 121 EIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPSGVGFVDFPMDYVFSMADDVG 180 Query 180 GRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIP 239 G PGAL LP P +ALDRAAGLL+ A RPVIMAGTNVWWGHAEAALLRL EE IP Sbjct 181 GGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIP 240 Query 240 VLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVAD 299 VLMNGMARGVVPADH LAFSRAR KALGEADVAL+VGVPMDFRLGFG VFGS TQL+VAD Sbjct 241 VLMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVAD 300 Query 300 RVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDD 359 R EP R++PRPVAAGLYGDL A LSALAG GGTD Q WI L TAET RDLEKAEL DD Sbjct 301 RAEPDRDYPRPVAAGLYGDLPAILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDD 360 Query 360 RIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPG 419 R+PLHPMRVYAELA+LL+RDA+VVIDAGDFGSYAGR+IDSYLPGCWLDSGPFGCLGSGPG Sbjct 361 RLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDSYLPGCWLDSGPFGCLGSGPG 420 Query 420 YALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEAL 479 YALAAKLARP RQVVLLQGDGAFGFSGMEWDTLVRHNV VVSVIGNNGIWGLEKHPMEAL Sbjct 421 YALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEAL 480 Query 480 YGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVA 539 YGYSVVAELRPGTRYDEVVRALGGHGELVSVP ELRPALERAF +GLP+VVNVLTDPSVA Sbjct 481 YGYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVA 540 Query 540 YPRRSNLA 547 YPRRSNLA Sbjct 541 YPRRSNLA 548 >gi|296164806|ref|ZP_06847365.1| acetolactate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295899820|gb|EFG79267.1| acetolactate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=550 Score = 920 bits (2377), Expect = 0.0, Method: Compositional matrix adjust. Identities = 468/550 (86%), Positives = 495/550 (90%), Gaps = 3/550 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTD P QT+HAGRL+ARRL+ASG+DTVFTLSGGHLFS+YDGCREEGIRLIDTRHEQTA Sbjct 1 MSTDAIPTQTLHAGRLVARRLRASGVDTVFTLSGGHLFSVYDGCREEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 FAAEGWSKVTRVPGVAALTAGPG+TNGMSAMAAAQQNQSPLVVLGGRAPA RWGMGSLQ Sbjct 61 TFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPAGRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA +AG LVD+AL+AAV APSGV FVDFPMDH FS+S D+G Sbjct 121 EIDHVPFVAPLARFAATAQSAGDAGRLVDEALRAAVGAPSGVGFVDFPMDHVFSVSEDHG 180 Query 181 RPGALTELPAGPTPA---GDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERH 237 RPGALT+LP GP G AL RAA LLS A+RPVIMAGTNVWWG EAALLRL EER Sbjct 181 RPGALTDLPPGPGADDLDGQALGRAASLLSGAKRPVIMAGTNVWWGRGEAALLRLAEERQ 240 Query 238 IPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIV 297 IPVLMNGMARG VPADH LAFSRAR KALGEADVALI+GVPMDFRLGFG VFG T+LIV Sbjct 241 IPVLMNGMARGAVPADHPLAFSRARGKALGEADVALILGVPMDFRLGFGAVFGPQTRLIV 300 Query 298 ADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELV 357 DR EP R+HPRPV A LYGDL + L+ALA G DH+ WIEEL TAET AR EKA+L Sbjct 301 VDRAEPERKHPRPVDAELYGDLLSILAALAAGDGADHRDWIEELRTAETAARGKEKADLA 360 Query 358 DDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSG 417 DDR+PLHPMRVYAELA +L+RDA+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSG Sbjct 361 DDRVPLHPMRVYAELAPMLDRDAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCLGSG 420 Query 418 PGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPME 477 PGYALAAKLARP RQVVLLQGDGAFGFSGMEWDTLVRHNV V SVIGNNGIWGLEKHPME Sbjct 421 PGYALAAKLARPDRQVVLLQGDGAFGFSGMEWDTLVRHNVPVASVIGNNGIWGLEKHPME 480 Query 478 ALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPS 537 ALYGYSVVAELRPGTRYDEVVRALGGHGELVS PAELRPALERAFASGLPAVVNVLTDP+ Sbjct 481 ALYGYSVVAELRPGTRYDEVVRALGGHGELVSAPAELRPALERAFASGLPAVVNVLTDPA 540 Query 538 VAYPRRSNLA 547 VAYPRRSNLA Sbjct 541 VAYPRRSNLA 550 >gi|342861276|ref|ZP_08717924.1| hypothetical protein MCOL_20431 [Mycobacterium colombiense CECT 3035] gi|342131176|gb|EGT84457.1| hypothetical protein MCOL_20431 [Mycobacterium colombiense CECT 3035] Length=547 Score = 910 bits (2351), Expect = 0.0, Method: Compositional matrix adjust. Identities = 465/547 (86%), Positives = 489/547 (90%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M+TD PAQT+HAGRL+ARRL+ASG+DTVFTLSGGHLFSIYDGCR+EGIRLIDTRHEQTA Sbjct 1 MTTDAVPAQTLHAGRLVARRLRASGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 FAAEGWSKVTR PGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPA RWGMGSLQ Sbjct 61 TFAAEGWSKVTRSPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPAQRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA++AG LVD AL+AAV APSGV FVDFPMDHAFSMS D+G Sbjct 121 EIDHVPFVAPLARFAATAQSADDAGRLVDDALRAAVGAPSGVGFVDFPMDHAFSMSDDDG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGAL +LP GP P G AL RAA LLS AQRPVIMAGTNVWWG EAALLRL EE IPV Sbjct 181 RPGALVDLPPGPAPDGQALSRAAALLSAAQRPVIMAGTNVWWGRGEAALLRLAEELQIPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARG VPADH LAFSR R KALGEADVALIVGVPMDFRLGFG VFG+ TQLIV DR Sbjct 241 LMNGMARGAVPADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGAQTQLIVVDR 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 EP R HPRPV A LYGDL L+ALA + GTDH+ WI EL TAET +R E+AEL DDR Sbjct 301 AEPERGHPRPVQAELYGDLLTILAALAPATGTDHRDWIGELRTAETASRATEQAELADDR 360 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 PLHPMRVYAELA +L+RDA+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSGPGY Sbjct 361 SPLHPMRVYAELAPMLDRDAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCLGSGPGY 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLA P RQVVLLQGDGAFGFSGMEWDTLVRHNV VVSVIGNNGIWGLE HPM+ALY Sbjct 421 ALAAKLAHPDRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEHHPMKALY 480 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEV RALGGHGELV+ P ELRPALERAFASGLPAVVNVLTDP VAY Sbjct 481 GYSVVAELRPGTRYDEVARALGGHGELVATPGELRPALERAFASGLPAVVNVLTDPEVAY 540 Query 541 PRRSNLA 547 PRRSNLA Sbjct 541 PRRSNLA 547 >gi|306776039|ref|ZP_07414376.1| acetolactate synthase ilvG [Mycobacterium tuberculosis SUMu001] gi|308215491|gb|EFO74890.1| acetolactate synthase ilvG [Mycobacterium tuberculosis SUMu001] Length=451 Score = 901 bits (2329), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/451 (100%), Positives = 451/451 (100%), Gaps = 0/451 (0%) Query 97 QNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAV 156 QNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAV Sbjct 1 QNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAV 60 Query 157 SAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMA 216 SAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMA Sbjct 61 SAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMA 120 Query 217 GTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVG 276 GTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVG Sbjct 121 GTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVG 180 Query 277 VPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQG 336 VPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQG Sbjct 181 VPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQG 240 Query 337 WIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRM 396 WIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRM Sbjct 241 WIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRM 300 Query 397 IDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHN 456 IDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHN Sbjct 301 IDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHN 360 Query 457 VAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRP 516 VAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRP Sbjct 361 VAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRP 420 Query 517 ALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 ALERAFASGLPAVVNVLTDPSVAYPRRSNLA Sbjct 421 ALERAFASGLPAVVNVLTDPSVAYPRRSNLA 451 >gi|118462562|ref|YP_882081.1| hypothetical protein MAV_2895 [Mycobacterium avium 104] gi|118163849|gb|ABK64746.1| acetolactate synthase large subunit [Mycobacterium avium 104] Length=548 Score = 900 bits (2327), Expect = 0.0, Method: Compositional matrix adjust. Identities = 458/547 (84%), Positives = 490/547 (90%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M++D A T+HAGRL+ARRL+ASG+DTVFTLSGGHLFSIYDGCR+EGIRLIDTRHEQTA Sbjct 2 MTSDATSAPTLHAGRLVARRLRASGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA 61 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 FAAEGWSKVTR+PGVAALTAGPG+TNGMSAMAAAQQN SPLVVLGGRAPA RW MGSLQ Sbjct 62 TFAAEGWSKVTRLPGVAALTAGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWAMGSLQ 121 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA++AG LVD AL+AAV APSGV FVDFPMDH FSM+ D+G Sbjct 122 EIDHVPFVAPLARFAATAQSADDAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMAEDDG 181 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGAL +LP P P G AL RAAGLLS A+RPVIMAGTNVWWGH EAALLRL EE IPV Sbjct 182 RPGALVDLPREPEPDGAALGRAAGLLSGAKRPVIMAGTNVWWGHGEAALLRLAEELAIPV 241 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARG VPADH LAFSR R KALGEADVALIVGVPMDFRLGFG VFG T+LIVADR Sbjct 242 LMNGMARGAVPADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGPHTRLIVADR 301 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 V P R+HPRPV A LYGDL L+ALA +GG DH+ WI+EL TAET AR E+AEL DDR Sbjct 302 VAPERKHPRPVEAQLYGDLMTILAALATAGGGDHRDWIDELRTAETAARAAEQAELADDR 361 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 +PLHPMRVYAELA +L+RDA+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSGPGY Sbjct 362 VPLHPMRVYAELAPMLDRDAIVVIDAGDFGSYAGRVIDSYRPGCWLDSGPFGCLGSGPGY 421 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLARP+RQVVLLQGDGAFGFSGMEWDTLVRH V VVSVIGNNGIW LEKHPME LY Sbjct 422 ALAAKLARPERQVVLLQGDGAFGFSGMEWDTLVRHRVPVVSVIGNNGIWALEKHPMEQLY 481 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEV RALGGHGELV+ P ELRPALERAFASGLPAVVNVLTDP+VAY Sbjct 482 GYSVVAELRPGTRYDEVARALGGHGELVAAPGELRPALERAFASGLPAVVNVLTDPTVAY 541 Query 541 PRRSNLA 547 PRRSNLA Sbjct 542 PRRSNLA 548 >gi|254823247|ref|ZP_05228248.1| hypothetical protein MintA_25179 [Mycobacterium intracellulare ATCC 13950] Length=547 Score = 897 bits (2318), Expect = 0.0, Method: Compositional matrix adjust. Identities = 459/547 (84%), Positives = 485/547 (89%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MS D +QT+HAGRL+ARRLKASGIDTVFTLSGGHLFSIYDGCR+EGIRLIDTRHEQTA Sbjct 1 MSIDAPSSQTVHAGRLVARRLKASGIDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 FAAEGWSKVTRVPGVAALTAGPG+TNGMSAMAAAQQNQSPLVVLGGRAPA RWGMGSLQ Sbjct 61 TFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPAQRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA +AG LVD AL+AAV APSGV FVDFPMDH FSMS D Sbjct 121 EIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMSDDGP 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGAL ++P GP P AL RA GLL+ A+RPVIMAGTNVWWGH EAALLRL EE IPV Sbjct 181 RPGALIDVPPGPAPDDRALTRAVGLLAAAKRPVIMAGTNVWWGHGEAALLRLAEELQIPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARG V ADH LAFSR R KALGEADVALIVGVPMDFRLGFG VFG TQL+V DR Sbjct 241 LMNGMARGAVAADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGQQTQLVVVDR 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 V+P R HPRPV A LYGDL L+ALA +GG H+ W+EEL AET AR E AEL DDR Sbjct 301 VQPERRHPRPVQAELYGDLLTILAALATAGGAGHRDWVEELRAAETAARAKENAELADDR 360 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 +PLHPMRVYAELA +L+RDA+VVIDAGDFGSYAGR+IDSYLPGCWLDSGPFGCLGSGPGY Sbjct 361 VPLHPMRVYAELAPMLDRDAIVVIDAGDFGSYAGRVIDSYLPGCWLDSGPFGCLGSGPGY 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNV VVSVIGNNGIWGLEKHPMEALY Sbjct 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEALY 480 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEV RALG HGELV+ P ELRPALERAFASG+PAVVNVLTDP +AY Sbjct 481 GYSVVAELRPGTRYDEVARALGAHGELVAAPGELRPALERAFASGMPAVVNVLTDPDIAY 540 Query 541 PRRSNLA 547 PRRSNLA Sbjct 541 PRRSNLA 547 >gi|254775371|ref|ZP_05216887.1| hypothetical protein MaviaA2_11966 [Mycobacterium avium subsp. avium ATCC 25291] Length=547 Score = 886 bits (2290), Expect = 0.0, Method: Compositional matrix adjust. Identities = 459/547 (84%), Positives = 490/547 (90%), Gaps = 0/547 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M++D PA T+HAGRL+ARRL+ASG+DTVFTLSGGHLFSIYDGCR+EGIRLIDTRHEQTA Sbjct 1 MTSDATPAPTLHAGRLVARRLRASGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 FAAEGWSKVTR+PGVAALTAGPG+TNGMSAMAAAQQN SPLVVLGGRAPA RWGMGSLQ Sbjct 61 TFAAEGWSKVTRLPGVAALTAGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA +AG LVD AL+AAV APSGV FVDFPMDH FSM+ D+G Sbjct 121 EIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMAEDDG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 RPGAL +LP P P G AL RAAGLLS A+RPVIMAGTNVWWGH EAALLRL EE PV Sbjct 181 RPGALVDLPREPEPDGAALGRAAGLLSGAKRPVIMAGTNVWWGHGEAALLRLAEELATPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 LMNGMARG VPADH LAFSR R KALGEADVALIVGVPMDFRLGFG VFG T+LIVADR Sbjct 241 LMNGMARGAVPADHPLAFSRVRGKALGEADVALIVGVPMDFRLGFGAVFGPHTRLIVADR 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 V P R+HPRPV A LYGDL L+ALA +GG DH+ WI+EL TAET AR E+AEL DDR Sbjct 301 VAPERKHPRPVEAQLYGDLMTILAALATAGGGDHRDWIDELRTAETAARAAEQAELADDR 360 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 +PLHPMRVYAELA +L+RDA+VVIDAGDFGSYAGR+IDSY PGCWLDSGPFGCLGSGPGY Sbjct 361 VPLHPMRVYAELAPMLDRDAIVVIDAGDFGSYAGRVIDSYRPGCWLDSGPFGCLGSGPGY 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 ALAAKLARP+RQVVLLQGDGAFGFSGMEWDTLVRH V VVSVIGNNGIW LEKHPME LY Sbjct 421 ALAAKLARPERQVVLLQGDGAFGFSGMEWDTLVRHRVPVVSVIGNNGIWALEKHPMEQLY 480 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GYSVVAELRPGTRYDEV RALGGHGELV+ P ELRPALERAFASGLPAVVNVLTDP+VAY Sbjct 481 GYSVVAELRPGTRYDEVARALGGHGELVAAPGELRPALERAFASGLPAVVNVLTDPTVAY 540 Query 541 PRRSNLA 547 PRRSNLA Sbjct 541 PRRSNLA 547 >gi|289443294|ref|ZP_06433038.1| conserved hypothetical protein [Mycobacterium tuberculosis T46] gi|289416213|gb|EFD13453.1| conserved hypothetical protein [Mycobacterium tuberculosis T46] Length=423 Score = 843 bits (2178), Expect = 0.0, Method: Compositional matrix adjust. Identities = 422/423 (99%), Positives = 423/423 (100%), Gaps = 0/423 (0%) Query 125 VPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGA 184 +PFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGA Sbjct 1 MPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGA 60 Query 185 LTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNG 244 LTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNG Sbjct 61 LTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNG 120 Query 245 MARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPA 304 MARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPA Sbjct 121 MARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPA 180 Query 305 REHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLH 364 REHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLH Sbjct 181 REHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLH 240 Query 365 PMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAA 424 PMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAA Sbjct 241 PMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAA 300 Query 425 KLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSV 484 KLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSV Sbjct 301 KLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSV 360 Query 485 VAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRS 544 VAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRS Sbjct 361 VAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRS 420 Query 545 NLA 547 NLA Sbjct 421 NLA 423 >gi|284046651|ref|YP_003396991.1| thiamine pyrophosphate protein TPP binding domain protein [Conexibacter woesei DSM 14684] gi|283950872|gb|ADB53616.1| thiamine pyrophosphate protein TPP binding domain protein [Conexibacter woesei DSM 14684] Length=549 Score = 713 bits (1840), Expect = 0.0, Method: Compositional matrix adjust. Identities = 362/549 (66%), Positives = 423/549 (78%), Gaps = 2/549 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 MSTDT +H GRLIARRLKA G+ +FTLSGGH+F IYDGCR EGI ++D RHEQ A Sbjct 1 MSTDTQQETRLHGGRLIARRLKAHGVTKLFTLSGGHIFPIYDGCRAEGIDIVDVRHEQAA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 AFAAEGW+KVTR PGVAA+TAGPG+TN MSA+A+AQ N SP++VLGGRAPALRWG GSLQ Sbjct 61 AFAAEGWAKVTRTPGVAAVTAGPGVTNAMSAIASAQSNNSPVLVLGGRAPALRWGRGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFV P+ + AAT LVD AL+ A++ SG AF+DF MDH FS + + Sbjct 121 EIDHVPFVRPLTKLAATPDGTAEIPGLVDDALRVAMTPHSGPAFLDFAMDHVFSEAQEPA 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 AL GP G+A++RA LL+ A+RPVIMAGTN++WGH EAAL L E+ +PV Sbjct 181 SDAALLAPHLGPGADGNAIERAGALLAQAERPVIMAGTNLYWGHGEAALRALAEQLGVPV 240 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 +NG+ARG VPADH L FSRAR AL ADVAL++GVPMDFRLGFG FG+ T+LI D Sbjct 241 FLNGLARGCVPADHELFFSRARGAALKGADVALVIGVPMDFRLGFGESFGAETELISIDV 300 Query 301 VEPAREHPRPVAAGLYGDLTATLSAL--AGSGGTDHQGWIEELATAETMARDLEKAELVD 358 EP R+HPR VAA LYG L ATL AL A +GG D W E+L E E EL D Sbjct 301 AEPVRDHPRTVAAELYGALPATLDALREAAAGGPDRTRWHEQLRAVEEEKHAAEALELND 360 Query 359 DRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGP 418 +R PLHPMRVY LA +++R+A+VV D GDF SYAGR++DSY PGCWLD GPFGCLG+GP Sbjct 361 ERAPLHPMRVYKGLAEVIDRNAIVVCDGGDFVSYAGRVVDSYEPGCWLDPGPFGCLGTGP 420 Query 419 GYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEA 478 GYALAAK+ARP+RQVVLL GDGAFGFSG+E+DTL RH V VV V+GNNGIW LEKHPME Sbjct 421 GYALAAKIARPERQVVLLLGDGAFGFSGLEFDTLARHGVNVVGVMGNNGIWALEKHPMEF 480 Query 479 LYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSV 538 LYGYSV AELRPGTRYDEVV ALGGHGELV P +LR AL+RAF++G+PA+VNVLTDP+V Sbjct 481 LYGYSVAAELRPGTRYDEVVGALGGHGELVERPEQLRGALDRAFSAGVPALVNVLTDPTV 540 Query 539 AYPRRSNLA 547 YPR+SNLA Sbjct 541 VYPRKSNLA 549 >gi|41407631|ref|NP_960467.1| hypothetical protein MAP1533 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41395984|gb|AAS03850.1| hypothetical protein MAP_1533 [Mycobacterium avium subsp. paratuberculosis K-10] Length=335 Score = 553 bits (1426), Expect = 2e-155, Method: Compositional matrix adjust. Identities = 284/335 (85%), Positives = 299/335 (90%), Gaps = 0/335 (0%) Query 213 VIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVA 272 +IMAGTNVWWGH EAALLRL EE IPVLMNGMARG VPADH LAFSR R KALGEADVA Sbjct 1 MIMAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVA 60 Query 273 LIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGT 332 LIVGVPMDFRLGFG VFG T+LIVADRV P R+HPRPV A LYGDL L+ALA +GG Sbjct 61 LIVGVPMDFRLGFGAVFGPHTRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGG 120 Query 333 DHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSY 392 DH WI+EL TAET AR E+AEL DDR+PLHPMRVYAELA +L+RDA+VVIDAGDFGSY Sbjct 121 DHPDWIDELRTAETAARAAERAELADDRVPLHPMRVYAELAPMLDRDAIVVIDAGDFGSY 180 Query 393 AGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTL 452 AGR+IDSY PGCWLDSGPFGCLGSGPGYALAAKLARP+RQVVLLQGDGAFGFSGMEWDTL Sbjct 181 AGRVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTL 240 Query 453 VRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPA 512 VRH V VVSVIGNNGIW LEKHPME LYGYSVVAELRPGTRYDEV RALGGHGELV+ P Sbjct 241 VRHRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPG 300 Query 513 ELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 ELRPALERAFASGLPAVVNVLTDP+VAYPRRSNLA Sbjct 301 ELRPALERAFASGLPAVVNVLTDPTVAYPRRSNLA 335 >gi|336457583|gb|EGO36588.1| thiamine pyrophosphate-dependent enzyme, probable carboxylase/decarboxylase/carboligase [Mycobacterium avium subsp. paratuberculosis S397] Length=333 Score = 551 bits (1420), Expect = 1e-154, Method: Compositional matrix adjust. Identities = 283/333 (85%), Positives = 297/333 (90%), Gaps = 0/333 (0%) Query 215 MAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALI 274 MAGTNVWWGH EAALLRL EE IPVLMNGMARG VPADH LAFSR R KALGEADVALI Sbjct 1 MAGTNVWWGHGEAALLRLAEELAIPVLMNGMARGAVPADHPLAFSRVRGKALGEADVALI 60 Query 275 VGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDH 334 VGVPMDFRLGFG VFG T+LIVADRV P R+HPRPV A LYGDL L+ALA +GG DH Sbjct 61 VGVPMDFRLGFGAVFGPHTRLIVADRVAPERKHPRPVEAQLYGDLMTILAALATAGGGDH 120 Query 335 QGWIEELATAETMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAG 394 WI+EL TAET AR E+AEL DDR+PLHPMRVYAELA +L+RDA+VVIDAGDFGSYAG Sbjct 121 PDWIDELRTAETAARAAERAELADDRVPLHPMRVYAELAPMLDRDAIVVIDAGDFGSYAG 180 Query 395 RMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVR 454 R+IDSY PGCWLDSGPFGCLGSGPGYALAAKLARP+RQVVLLQGDGAFGFSGMEWDTLVR Sbjct 181 RVIDSYRPGCWLDSGPFGCLGSGPGYALAAKLARPERQVVLLQGDGAFGFSGMEWDTLVR 240 Query 455 HNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAEL 514 H V VVSVIGNNGIW LEKHPME LYGYSVVAELRPGTRYDEV RALGGHGELV+ P EL Sbjct 241 HRVPVVSVIGNNGIWALEKHPMEQLYGYSVVAELRPGTRYDEVARALGGHGELVAAPGEL 300 Query 515 RPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 RPALERAFASGLPAVVNVLTDP+VAYPRRSNLA Sbjct 301 RPALERAFASGLPAVVNVLTDPTVAYPRRSNLA 333 >gi|315502304|ref|YP_004081191.1| thiamine pyrophosphate tpp-binding domain-containing protein [Micromonospora sp. L5] gi|315408923|gb|ADU07040.1| thiamine pyrophosphate TPP-binding domain-containing protein [Micromonospora sp. L5] Length=540 Score = 498 bits (1282), Expect = 1e-138, Method: Compositional matrix adjust. Identities = 270/538 (51%), Positives = 347/538 (65%), Gaps = 7/538 (1%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 H G L L+A G+ +FTLSGGH+F +YD G L D RHEQ+A FAAE +K+ Sbjct 8 HGGDLALAALRAHGVREMFTLSGGHVFPLYDAAHRAGFPLYDVRHEQSAVFAAEAVAKLQ 67 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R PG+A LTAGPG+TNG+S + +A N SP++VLGGRAP RWG GSLQE+DH+P VAPV Sbjct 68 RRPGLAVLTAGPGVTNGVSGLTSAFFNASPVLVLGGRAPQFRWGSGSLQEMDHLPLVAPV 127 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAG 191 + A T SA++ V AL A++ G F+DFP++ FS+ D P P Sbjct 128 TKHAETVFSADDIPRAVSAALTTALTPHRGPVFLDFPLEAVFSVG-DADLPAVTPPAPIE 186 Query 192 PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVP 251 P P D + +AA L++ A RPV++AG++V+ G A AL E +PV NGM RG +P Sbjct 187 PDP--DEVAKAARLIAGASRPVVIAGSDVYAGDAVEALRAAAESLRVPVFTNGMGRGALP 244 Query 252 ADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPV 311 +H LAF++AR AL ADV +++G P+DFRL FG FG + V D H +P Sbjct 245 PEHPLAFAKARRVALKGADVVVVIGTPLDFRLSFGD-FGDAQVVHVVDAPSQRAGHVQPA 303 Query 312 AAGLYGDLTATLSALAGSGG--TDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVY 369 AA GDL L A A G DH WI EL TAE A+ + E+ + P+ P R+Y Sbjct 304 AAPA-GDLRLILGAFADHAGDRADHADWIAELRTAEDAAKARDAEEMAAETDPIRPARIY 362 Query 370 AELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARP 429 EL L DA+ + D GDF SYAGR ++ PG WLD GP+GCLG+G GYA+ A+++ P Sbjct 363 GELRRALAPDAITIGDGGDFVSYAGRYLEPAQPGTWLDPGPYGCLGTGMGYAMGARVSHP 422 Query 430 QRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELR 489 RQ+ +L GDGA GFS M+ ++LVR + VV V+GNNGIWGLEKHPM A+YGY V A+L+ Sbjct 423 DRQICVLMGDGAAGFSLMDVESLVRQKLPVVIVVGNNGIWGLEKHPMRAMYGYDVAADLQ 482 Query 490 PGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 PG RYD+VV ALGG GE V A+L PAL RAF SG+P +VNVLTDP+ AYPR SNLA Sbjct 483 PGLRYDKVVEALGGAGETVEKAADLGPALGRAFDSGVPYLVNVLTDPADAYPRSSNLA 540 >gi|302865748|ref|YP_003834385.1| thiamine pyrophosphate TPP-binding domain-containing protein [Micromonospora aurantiaca ATCC 27029] gi|302568607|gb|ADL44809.1| thiamine pyrophosphate TPP-binding domain-containing protein [Micromonospora aurantiaca ATCC 27029] Length=540 Score = 497 bits (1280), Expect = 2e-138, Method: Compositional matrix adjust. Identities = 270/538 (51%), Positives = 347/538 (65%), Gaps = 7/538 (1%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 H G L L+A G+ +FTLSGGH+F +YD G L D RHEQ+A FAAE +K+ Sbjct 8 HGGDLALAALRAHGVREMFTLSGGHVFPLYDAAHRAGFPLYDVRHEQSAVFAAEAVAKLQ 67 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R PG+A LTAGPG+TNG+S + +A N SP++VLGGRAP RWG GSLQE+DH+P VAPV Sbjct 68 RRPGLAVLTAGPGVTNGVSGLTSAFFNASPVLVLGGRAPQFRWGSGSLQEMDHLPLVAPV 127 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAG 191 + A T SA++ V AL A++ G F+DFP++ FS+ D P P Sbjct 128 TKHAETVFSADDIPRAVSAALTTALTPHRGPVFLDFPLEAVFSVG-DADLPAVTPPAPIE 186 Query 192 PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVP 251 P P D + +AA L++ A RPV++AG++V+ G A AL E +PV NGM RG +P Sbjct 187 PDP--DEVAKAARLIAGASRPVVIAGSDVYAGDAVEALRAAAESLRVPVFTNGMGRGALP 244 Query 252 ADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPV 311 +H LAF++AR AL ADV +++G P+DFRL FG FG + V D H +P Sbjct 245 PEHPLAFAKARRVALKGADVVVVIGTPLDFRLSFGD-FGDAQVVHVVDAPSQRAGHVQPA 303 Query 312 AAGLYGDLTATLSALAGSGG--TDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVY 369 AA GDL L A A G DH WI EL TAE A+ + E+ + P+ P R+Y Sbjct 304 AAPA-GDLRLILGAFADHTGDRADHADWIAELRTAEDAAKARDAEEMAAETDPIRPARIY 362 Query 370 AELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARP 429 EL L DA+ + D GDF SYAGR ++ PG WLD GP+GCLG+G GYA+ A+++ P Sbjct 363 GELRRALAPDAITIGDGGDFVSYAGRYLEPAQPGTWLDPGPYGCLGTGMGYAMGARVSHP 422 Query 430 QRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELR 489 RQ+ +L GDGA GFS M+ ++LVR + VV V+GNNGIWGLEKHPM A+YGY V A+L+ Sbjct 423 DRQICVLMGDGAAGFSLMDVESLVRQKLPVVIVVGNNGIWGLEKHPMRAMYGYDVAADLQ 482 Query 490 PGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 PG RYD+VV ALGG GE V A+L PAL RAF SG+P +VNVLTDP+ AYPR SNLA Sbjct 483 PGLRYDKVVEALGGAGETVEKAADLGPALGRAFDSGVPYLVNVLTDPADAYPRSSNLA 540 >gi|296270873|ref|YP_003653505.1| thiamine pyrophosphate protein domain-containing protein [Thermobispora bispora DSM 43833] gi|296093660|gb|ADG89612.1| thiamine pyrophosphate protein domain protein TPP-binding protein [Thermobispora bispora DSM 43833] Length=548 Score = 497 bits (1279), Expect = 3e-138, Method: Compositional matrix adjust. Identities = 272/550 (50%), Positives = 355/550 (65%), Gaps = 19/550 (3%) Query 9 QTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWS 68 + HAG + KA G +T+FTLSGGH+F +YDG EG+R++D RHEQ+A FAAE + Sbjct 3 SSKHAGDVAVAVAKAYGAETMFTLSGGHVFPLYDGAVHEGMRIVDVRHEQSAVFAAEATA 62 Query 69 KVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFV 128 ++TR PG+A LTAGPGITNG+S +A A N SP+VVLGGRAP RWG G+LQE+DH P V Sbjct 63 RLTRKPGLAVLTAGPGITNGVSGIATAHFNGSPVVVLGGRAPRSRWGSGALQELDHPPLV 122 Query 129 APVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSD-NGRPGALTE 187 PV++ A T A++ G V++A + A+ G F+DF MD F+ + + RP E Sbjct 123 EPVSKLAFTGSGADSIGQDVERAFRTALEPHRGPVFLDFYMDDLFAPAQEFTPRP----E 178 Query 188 LPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMAR 247 +P G P DAL A LL+ A+RPV++ G++VW AE A EE IPV++NG R Sbjct 179 VPKGLDPDPDALAGIARLLAEAERPVLVLGSDVWLNAAEQAAREFAEEWRIPVVLNGQGR 238 Query 248 GVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREH 307 G++P+ H L +RAR A G+AD+ L+ G P+DFRL +G FG +A RV + Sbjct 239 GILPSGHELLVTRARGTAFGKADLVLVAGTPLDFRLNYG-WFGGKDGAPLA-RVVHIVDA 296 Query 308 PRPVAA--GLYG----DLTATLSALAGSGGT------DHQGWIEELATAETMARDLEKAE 355 P +A GL G DLTA LA + GT + W+ L A + Sbjct 297 PSQIATHVGLSGSAAGDLTAVFRGLATACGTAGVNPGKYDPWLTTLRDTAAAAIAKDAEL 356 Query 356 LVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLG 415 L D P+HPMR+Y EL +L+ DA+++ D GDF SYAG+ ++ PG WLD GPFGCLG Sbjct 357 LNSDADPIHPMRIYGELNKVLDDDAVIIGDGGDFVSYAGKYLEPRRPGNWLDPGPFGCLG 416 Query 416 SGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHP 475 +G GYA+AA+L RP Q+VLL GDGA GFS M+ DTLVRH + VV + GNNGIWGLEKHP Sbjct 417 TGLGYAIAARLVRPSSQIVLLLGDGAAGFSLMDVDTLVRHRLPVVMICGNNGIWGLEKHP 476 Query 476 MEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTD 535 M LYGY V A+L+P RYD+VV ALGG GELV+ P E+ PAL RAF + +P +VN+ TD Sbjct 477 MRLLYGYDVAADLQPACRYDQVVAALGGAGELVTSPDEIGPALRRAFEADVPYLVNIATD 536 Query 536 PSVAYPRRSN 545 P VAYPR + Sbjct 537 PEVAYPRNTT 546 >gi|330466174|ref|YP_004403917.1| hypothetical protein VAB18032_10995 [Verrucosispora maris AB-18-032] gi|328809145|gb|AEB43317.1| hypothetical protein VAB18032_10995 [Verrucosispora maris AB-18-032] Length=540 Score = 493 bits (1268), Expect = 4e-137, Method: Compositional matrix adjust. Identities = 271/543 (50%), Positives = 356/543 (66%), Gaps = 17/543 (3%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 H G L L+A G+ +FTLSGGH+F +YD + G L D RHEQ+A FAAE +K+ Sbjct 8 HGGELALAALRAYGVREMFTLSGGHVFPLYDAAHKTGFPLYDVRHEQSAVFAAEAVAKLQ 67 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R PG+A LTAGPG+TNG+S + +A N SP++V+GGRAP RWG GSLQE+DH+P VAPV Sbjct 68 RRPGLAVLTAGPGVTNGISGLTSAYFNASPVLVMGGRAPQFRWGSGSLQEMDHLPLVAPV 127 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAG 191 + A T SA++ V AL A++ G F+DFP++ FS +LPAG Sbjct 128 TKHAETVFSADDIPRAVAAALTTALTPHRGPVFLDFPLEAIFSTGD--------ADLPAG 179 Query 192 PT-----PAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMA 246 P D + +AAGL++ AQRPV++AG++V+ G A AAL E +PV NGM Sbjct 180 PALDPVEADPDEVAKAAGLIAGAQRPVVIAGSDVYAGDAVAALRAAAEALDVPVFTNGMG 239 Query 247 RGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPARE 306 RG +P +H LAF++AR AL ADV ++VG P+DFRL FG FG T + + D Sbjct 240 RGALPPEHPLAFAKARRVALKGADVVVVVGTPLDFRLSFGD-FGDATVVHIVDAPSQRAT 298 Query 307 HPRPVAAGLYGDLTATLSALAGSGG--TDHQGWIEELATAETMARDLEKAELVDDRIPLH 364 H +P A GDL A L+ LAG G DH W+ +L TAE A+ + E+ + P+ Sbjct 299 HVQPAVAPA-GDLRAILTTLAGYTGDRADHTDWVAQLRTAEDAAKARDAEEMAAETDPIR 357 Query 365 PMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAA 424 P RVY EL +L RDA+ + D GDF SYAGR ++ PG WLD GP+GCLG+G GYA+ A Sbjct 358 PARVYGELRKVLARDAITIGDGGDFVSYAGRYLEPAQPGTWLDPGPYGCLGTGMGYAMGA 417 Query 425 KLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSV 484 ++ P RQ+ +L GDGA GFS M+ ++LVR + VV V+GNNGIWGLEKHPM A+YGY V Sbjct 418 RVTHPDRQICVLMGDGAAGFSLMDVESLVRQKLPVVMVVGNNGIWGLEKHPMRAMYGYDV 477 Query 485 VAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRS 544 A+L+P RYD+VV ALGG GE V+ A+L PAL+RAF +G+P +VNV+TDP+ AYPR S Sbjct 478 AADLQPELRYDQVVTALGGAGETVAKAADLGPALQRAFDAGVPYLVNVITDPADAYPRSS 537 Query 545 NLA 547 NLA Sbjct 538 NLA 540 >gi|271969508|ref|YP_003343704.1| acetolactate synthase [Streptosporangium roseum DSM 43021] gi|270512683|gb|ACZ90961.1| putative acetolactate synthase [Streptosporangium roseum DSM 43021] Length=550 Score = 490 bits (1262), Expect = 2e-136, Method: Compositional matrix adjust. Identities = 272/549 (50%), Positives = 354/549 (65%), Gaps = 21/549 (3%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 HAG + KA GI+T+FTLSGGH+F +YDG EG+ ++D RHEQ+A FAAE +++T Sbjct 6 HAGDIAVAVSKAYGIETMFTLSGGHVFPLYDGAVHEGMPILDVRHEQSAVFAAEATARLT 65 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R PG+A LTAGPG+TNG+S +A A N SP+VV+GGRAP RWG G+LQEIDH P AP+ Sbjct 66 RRPGLAVLTAGPGVTNGVSGVATAHFNGSPVVVMGGRAPQSRWGSGALQEIDHPPLFAPI 125 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTEL--P 189 + A T ++ V+ A + A++ G F+DF MDH F+ + P +TE P Sbjct 126 TKLAFTGSGPDSVAEDVEMAFRTALAPHRGPVFLDFHMDHLFAAAPP---PDHVTETLTP 182 Query 190 AGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGV 249 + P DAL A LL+ A+RPV++ G++VW AE EE +PV+ NG RG+ Sbjct 183 SPLEPDPDALAGIARLLAEAERPVLVLGSDVWMDRAEEVARSFAEEFRLPVIPNGQGRGI 242 Query 250 VPADHRLAFSRARSKALGEADVALIVGVPMDFRLG---FGGVFGSTTQLIV--ADRVEPA 304 +PA H L +RAR AL +AD+ ++ G PMDFRLG FGG G+ +V AD Sbjct 243 LPAGHELLVTRARGLALTQADLVIVAGAPMDFRLGYGWFGGKDGAPLARVVHLADAPSQL 302 Query 305 REHPRP--VAAGLYGDLTATLSAL------AGSGGTDHQGWIEELATAETMARDLEKAEL 356 H P VAAG DL+ L AG + W+ L+ A A + L Sbjct 303 TTHMEPSGVAAG---DLSLVFWGLGTACNQAGVSPKSYAPWLSRLSEAAASAVAADAGLL 359 Query 357 VDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGS 416 D P+HPMR+Y ELA +L DA+V+ D GDF SYAG+ ++ PG WLD GP+GCLG+ Sbjct 360 ASDSDPIHPMRIYGELAKVLADDAVVIGDGGDFVSYAGKYVEPKQPGNWLDPGPYGCLGT 419 Query 417 GPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPM 476 G GYA+AA+LARP QVVLL GDGA GFS M+ DTLVRH + VV + GNNG+WGLEKHPM Sbjct 420 GLGYAIAARLARPSSQVVLLLGDGAAGFSLMDVDTLVRHRLPVVMICGNNGMWGLEKHPM 479 Query 477 EALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDP 536 + LYGY V A+L+P RYD+VV ALGG GELV+ P+++ PAL RAF SG+P +VN+ TDP Sbjct 480 QMLYGYDVAADLQPQCRYDQVVTALGGGGELVTDPSQIGPALLRAFDSGVPYMVNIATDP 539 Query 537 SVAYPRRSN 545 SVAYPR + Sbjct 540 SVAYPRNTT 548 >gi|145593758|ref|YP_001158055.1| hypothetical protein Strop_1207 [Salinispora tropica CNB-440] gi|145303095|gb|ABP53677.1| thiamine pyrophosphate enzyme domain protein TPP-binding [Salinispora tropica CNB-440] Length=540 Score = 473 bits (1218), Expect = 3e-131, Method: Compositional matrix adjust. Identities = 265/538 (50%), Positives = 348/538 (65%), Gaps = 7/538 (1%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 H G L L+A G+ +FTLSGGH+F +YD + G + D RHEQ+A FAAE +K+ Sbjct 8 HGGALALAVLRAHGVREMFTLSGGHIFPLYDAAHQLGFPIYDVRHEQSAVFAAEAVAKLQ 67 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R PG+A LTAGPG+TNG+S + ++ N SP++VLGGRAP RWG GSLQE+DH+P V PV Sbjct 68 RRPGLAVLTAGPGVTNGISGLTSSFFNASPILVLGGRAPQFRWGAGSLQELDHLPLVTPV 127 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAG 191 + A T E V AL A++ G FVD P++ AFS++ D P P Sbjct 128 TKHAETVLRPEEIPRAVGAALTTALTPHRGPVFVDLPLEVAFSVA-DADLPAVAPIAPIE 186 Query 192 PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVP 251 PA A +AA L++ QRPV++AG++V+ G A AL E +PV NGM RG +P Sbjct 187 ADPAEVA--KAAVLIAQGQRPVLIAGSDVYAGDAVDALRAAAEALAVPVFTNGMGRGALP 244 Query 252 ADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPV 311 +H LAF+++R AL +ADV ++VG P+DFRL FG FG+ + V D H +P Sbjct 245 PEHPLAFAKSRRAALRDADVVVVVGTPLDFRLNFGD-FGAAAVVHVVDAPGQRAGHLQPA 303 Query 312 AAGLYGDLTATLSALAGSGG--TDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVY 369 AA GDL LSA A G DH W+ EL AE AR + AE+ + P+ P RVY Sbjct 304 AAPA-GDLRLILSAFAEYPGERVDHAEWVAELRAAEDAARTRDAAEMAAETDPIRPARVY 362 Query 370 AELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARP 429 EL +L +DA+ + D GDF SYAGR ++ PG WLD GP+GCLG+G GYA+ A++ P Sbjct 363 GELRRVLAQDAITIGDGGDFVSYAGRFLEPAQPGTWLDPGPYGCLGTGMGYAMGARVTHP 422 Query 430 QRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELR 489 RQ+ +L GDGA GFS ++ ++LVR + VV V+GNNGIWGLEKHPM ALYGY V A+L+ Sbjct 423 DRQICVLMGDGAAGFSLLDVESLVRQRLPVVIVVGNNGIWGLEKHPMRALYGYDVAADLQ 482 Query 490 PGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 P RYD+VV+ALGG GE V+ A+L AL RAF +G+P +VNV+TDP+ AYPR SNLA Sbjct 483 PELRYDQVVQALGGAGETVAKAADLGAALRRAFEAGVPYLVNVVTDPADAYPRSSNLA 540 >gi|238063176|ref|ZP_04607885.1| thiamine pyrophosphate protein domain-containing protein TPP-binding [Micromonospora sp. ATCC 39149] gi|237884987|gb|EEP73815.1| thiamine pyrophosphate protein domain-containing protein TPP-binding [Micromonospora sp. ATCC 39149] Length=540 Score = 473 bits (1216), Expect = 4e-131, Method: Compositional matrix adjust. Identities = 267/538 (50%), Positives = 344/538 (64%), Gaps = 7/538 (1%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 H G L L+A G+ +FTLSGGH+F +Y G L D RHEQ+A FAAE +K+ Sbjct 8 HGGELALAALRAHGVREMFTLSGGHVFPLYAAAHSAGFPLYDVRHEQSAVFAAEAVAKLN 67 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R PG+A LTAGPG+TNG+S + +A N SP++VLGGRAP RWG GSLQE+DH+P VAPV Sbjct 68 RRPGLAVLTAGPGVTNGVSGLTSAYFNASPVLVLGGRAPQFRWGSGSLQEMDHLPLVAPV 127 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAG 191 + A T + ++ V AL A++ G F+DFP++ FS+ D P A+ P Sbjct 128 TKHAETVFATDDIPRAVSAALTTALTPHRGPVFLDFPLEAVFSVG-DADLPEAVAPAPVE 186 Query 192 PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVP 251 P + + RAAGL++ A RPVI+AG++V+ G A AL E +PV NGM RG +P Sbjct 187 ADP--EEVARAAGLIAAAHRPVIIAGSDVYAGDAVEALRAAAEALRVPVFTNGMGRGALP 244 Query 252 ADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPV 311 H LAF++AR AL +ADV ++VG P+DFRL FG FG + V D H P Sbjct 245 PSHPLAFAKARRAALRDADVVVVVGTPLDFRLAFGD-FGDAQVVHVVDAPSQRAGHVAP- 302 Query 312 AAGLYGDLTATLSALAGSGG--TDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVY 369 A GDL L+A A G DH W+ L AE A+ + E+ + P+ P RVY Sbjct 303 AVSPAGDLRLILTAFAEHPGDRADHDDWVARLRVAEDAAKARDAEEMAAETDPIRPARVY 362 Query 370 AELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARP 429 EL L DA+ + D GDF SYAG+ ++ PG WLD GP+GCLG+G GYA+ A+++ P Sbjct 363 GELRRALAPDAITIGDGGDFVSYAGKYLEPAQPGTWLDPGPYGCLGTGMGYAMGARVSHP 422 Query 430 QRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELR 489 RQV +L GDGA GFS M+ ++LVR + VV V+GNNGIWGLEKHPM A+YGY V A+L+ Sbjct 423 DRQVCVLMGDGAAGFSLMDVESLVRQRLPVVIVVGNNGIWGLEKHPMRAMYGYDVAADLQ 482 Query 490 PGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 PG RYD VV ALGG GE V +L PAL+RAFASG+P +VNVLTDP+ AYPR SNLA Sbjct 483 PGLRYDRVVEALGGAGETVEKAGDLAPALDRAFASGVPYLVNVLTDPADAYPRSSNLA 540 >gi|159036746|ref|YP_001535999.1| hypothetical protein Sare_1100 [Salinispora arenicola CNS-205] gi|157915581|gb|ABV97008.1| thiamine pyrophosphate protein domain protein TPP-binding [Salinispora arenicola CNS-205] Length=540 Score = 473 bits (1216), Expect = 5e-131, Method: Compositional matrix adjust. Identities = 261/538 (49%), Positives = 342/538 (64%), Gaps = 7/538 (1%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVT 71 H G L L+ G+ +FTLSGGH+F +YD + G L D RHEQ+A FAAE +K+ Sbjct 8 HGGALALAALRGHGVREMFTLSGGHVFPLYDAAHQAGFPLYDVRHEQSAVFAAEAVAKLQ 67 Query 72 RVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPV 131 R P +A LTAGPG+TNG+S + ++ N SP++VLGGRAP RWG GSLQE+DH+P V PV Sbjct 68 RRPSLAVLTAGPGVTNGISGLTSSYFNASPVLVLGGRAPQFRWGAGSLQELDHLPLVTPV 127 Query 132 ARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAG 191 + A T A + V AL A++ G F+D P++ AFS++ D P P Sbjct 128 TKHAETIAHAADVPRAVGVALTTALTPHRGPVFLDLPLEVAFSVA-DADLPAVAPIAPIE 186 Query 192 PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVP 251 PA A AA L++ +RPV++AG++V+ G A L E +PV NG RG +P Sbjct 187 ADPAEVA--EAAALIAEGRRPVLVAGSDVYAGDAVEPLRAAAEALAVPVFTNGQGRGALP 244 Query 252 ADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPV 311 +H LAF+R+R AL +ADV ++VG P+DFRL FG FG+ T + V D H +P Sbjct 245 PEHPLAFTRSRRVALQKADVVVVVGTPLDFRLNFGD-FGAATVVHVVDAPSQRAGHVQPA 303 Query 312 AAGLYGDLTATLSALAGSGG--TDHQGWIEELATAETMARDLEKAELVDDRIPLHPMRVY 369 A GDL LSA A G DH W+ EL E AR + + + P+ P RVY Sbjct 304 VAPA-GDLRLILSAFAEYSGDRVDHTEWVAELRAVEDAARARDAVAMAAETDPIRPARVY 362 Query 370 AELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARP 429 EL +L RDA+ + D GDF SYAGR ++ PG WLD GP+GCLG+G GYA+ A++ P Sbjct 363 GELRRVLTRDAITIGDGGDFVSYAGRYLEPAQPGTWLDPGPYGCLGTGMGYAMGARVTHP 422 Query 430 QRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELR 489 RQV +L GDGA GFS ++ ++LVR + VV V+GNNGIWGLEKHPM A+YGY V A+L+ Sbjct 423 DRQVCVLMGDGAAGFSLLDVESLVRQRLPVVIVVGNNGIWGLEKHPMRAMYGYDVAADLQ 482 Query 490 PGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA 547 P RYD+VV+ALGG GE V+ A+L PAL RAF +G+P +VNVLTDP+ AYPR SNLA Sbjct 483 PELRYDQVVQALGGAGETVAKAADLGPALTRAFEAGVPYLVNVLTDPADAYPRSSNLA 540 >gi|256396829|ref|YP_003118393.1| hypothetical protein Caci_7728 [Catenulispora acidiphila DSM 44928] gi|256363055|gb|ACU76552.1| thiamine pyrophosphate protein domain protein TPP-binding [Catenulispora acidiphila DSM 44928] Length=559 Score = 464 bits (1194), Expect = 2e-128, Method: Compositional matrix adjust. Identities = 258/548 (48%), Positives = 345/548 (63%), Gaps = 14/548 (2%) Query 9 QTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEG--IRLIDTRHEQTAAFAAEG 66 Q H G++ +A G++T+FTLSGGH+FS+YDG + + ++D RHEQTA FAAE Sbjct 13 QPPHGGQISVEVARAHGVETMFTLSGGHVFSLYDGAVKADPPLPILDVRHEQTAVFAAEA 72 Query 67 WSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVP 126 +K+TR PG+A LTAGPGITNG+SA+ A N SP+VVLGGRA WG G+LQE+DH P Sbjct 73 TAKLTRKPGLAVLTAGPGITNGVSAVTTAHFNGSPVVVLGGRAADSNWGKGALQELDHPP 132 Query 127 FVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALT 186 +APV + +AT + +D A A + G F+D ++ AF + + +P Sbjct 133 LLAPVTKRSATVHTTAALASDLDDAFALADAPHRGPVFLDLSLEAAFDV---DAKPLPTV 189 Query 187 ELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMA 246 A TP DAL LL+ A +PV++ G++VW A+ A L EE +PV+ NGM Sbjct 190 GARAALTPDPDALAGIGDLLARAAKPVLVLGSDVWMDGADTAALAFAEETGVPVITNGMG 249 Query 247 RGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLG---FGGVFGSTTQLIVADRVEP 303 RG++P HR +RARS A G AD+ ++VG P+DFRLG FGG G+ +V P Sbjct 250 RGILPRGHRQLVTRARSAAFGGADLVIVVGTPLDFRLGYGLFGGRDGNPLAPVVHVVDSP 309 Query 304 AREHPR-PVAAGLYGDLTATLSALAGS-----GGTDHQGWIEELATAETMARDLEKAELV 357 + +AA GDL+A +A S + W+ L + A ++ L Sbjct 310 GQLSGHIGLAASAAGDLSAAFEGIAESWRKAAKPGAYADWLAALQDKASTAIAADRDLLT 369 Query 358 DDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSG 417 P+HP R+Y EL L DA+V+ D GDF S+AGR ++ GCWLD GP+GCLG+G Sbjct 370 AASDPIHPARIYGELLPRLADDAVVIGDGGDFVSFAGRFVEPGRAGCWLDPGPYGCLGTG 429 Query 418 PGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPME 477 GYA+AA+LARP QVVLL GDGA GFS M+ DTLVRH + VV V+GNN WGLEKHPM+ Sbjct 430 LGYAIAARLARPTSQVVLLVGDGAAGFSLMDVDTLVRHGLPVVMVMGNNACWGLEKHPMQ 489 Query 478 ALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPS 537 ALYGY V A+L P RYD+VV+ALGG GE V+ PA++ PAL+RAFASG+P +VN+ TD + Sbjct 490 ALYGYDVAADLNPDARYDKVVQALGGGGEFVTDPAQIGPALDRAFASGIPYLVNIATDQT 549 Query 538 VAYPRRSN 545 +AYPR + Sbjct 550 IAYPRSTT 557 >gi|311743932|ref|ZP_07717738.1| acetolactate synthase [Aeromicrobium marinum DSM 15272] gi|311313062|gb|EFQ82973.1| acetolactate synthase [Aeromicrobium marinum DSM 15272] Length=564 Score = 459 bits (1181), Expect = 6e-127, Method: Compositional matrix adjust. Identities = 268/556 (49%), Positives = 353/556 (64%), Gaps = 17/556 (3%) Query 2 STDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDG--CREEGIRLIDTRHEQT 59 T TA +H G + +A G++ +FTLSG H+F +YDG + + +ID RHE + Sbjct 10 DTTTASDAAVHGGVIATAVARAHGVEAMFTLSGAHVFPMYDGAVTADPPMPIIDVRHEPS 69 Query 60 AAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSL 119 A FAAE K+TR PG+A LTAGPG+TNG+S +A AQ SPLVV+GGRAPA RWGMGSL Sbjct 70 AVFAAEAIGKLTRTPGLAVLTAGPGVTNGVSPVAQAQFAGSPLVVVGGRAPANRWGMGSL 129 Query 120 QEIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDN 179 QE+DH P + +++ A TA + + G VD+A A S+ G FVD PMD F++++ Sbjct 130 QELDHPPIFSTISKSATTAHTCDVIGRTVDEAFALAGSSHRGPTFVDVPMDEFFNVAAPF 189 Query 180 GRPGALTELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIP 239 + P GD L A LL+ + RPV++ GT+VW AE A LR V E IP Sbjct 190 A---SAPAAADPIEPDGDDLAAVARLLAGSTRPVLIIGTDVWADGAEEAALRFVTETGIP 246 Query 240 VLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVAD 299 V+ NGM RG+VP H ++ARS ALG+ D+ ++VG P+DFRLG+G VFG + A Sbjct 247 VIANGMGRGIVPGGHPQLVTKARSTALGQCDLTVVVGTPLDFRLGYG-VFGGKEESPPAQ 305 Query 300 RVEPAREHPR-----PVAAGLYGDLTAT----LSALAGSGGT--DHQGWIEELATAETMA 348 V A + +AA GDLTA L L G+ G+ D W+E L + Sbjct 306 VVHLADSPGQLSGHADLAARAAGDLTAVFDGILRHLQGAAGSRPDWSAWLEALQQQVGLG 365 Query 349 RDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDS 408 + + A L P+HP R+Y EL L DA+V+ D GDF S+AG+ ++ PG WLD Sbjct 366 VERDNALLTATADPIHPARIYGELLPRLADDAVVIGDGGDFVSFAGKYVEPQRPGGWLDP 425 Query 409 GPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGI 468 GP+GCLG+G G A+AA++ARP QVVLL GDGA G S ++ DTLVRHN+ VV V+GNNG Sbjct 426 GPYGCLGAGLGAAMAARIARPSSQVVLLFGDGAAGMSIIDVDTLVRHNLPVVMVMGNNGA 485 Query 469 WGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPA 528 WGLEK PM+ LYGY V A+L PGTRYD+VV ALGG GELV+ P ++ PAL+RAFASG+P Sbjct 486 WGLEKGPMQMLYGYDVAADLIPGTRYDQVVTALGGGGELVTDPTQIGPALDRAFASGIPY 545 Query 529 VVNVLTDPSVAYPRRS 544 +VN++TD AYPR + Sbjct 546 LVNIITDVEAAYPRNT 561 >gi|119715945|ref|YP_922910.1| hypothetical protein Noca_1710 [Nocardioides sp. JS614] gi|119536606|gb|ABL81223.1| thiamine pyrophosphate enzyme domain protein TPP-binding protein [Nocardioides sp. JS614] Length=551 Score = 459 bits (1180), Expect = 7e-127, Method: Compositional matrix adjust. Identities = 271/544 (50%), Positives = 351/544 (65%), Gaps = 14/544 (2%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEG--IRLIDTRHEQTAAFAAEGWSK 69 HAG L +A G++T+FTLSG H+F +YDG + +RL+D RHEQTAAFAAE K Sbjct 8 HAGELAVAVAQAHGVETMFTLSGAHVFPLYDGAVKSATPLRLLDVRHEQTAAFAAEATGK 67 Query 70 VTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVA 129 +TRVPG+A LTAGPG+TNG+SA+A AQ SP+VV+GGRAP RWG G+LQE+D P +A Sbjct 68 LTRVPGLAVLTAGPGVTNGLSAVAQAQFAGSPMVVVGGRAPQGRWGTGALQELDQPPILA 127 Query 130 PVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELP 189 PV++ A T +A + QA A S G FVD PMD F+ + G P P Sbjct 128 PVSKLARTIPTAGEVLGGMHQAFVTAGSPHRGPVFVDVPMDELFNSA---GGPLPDVTAP 184 Query 190 AGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGV 249 G P DA+ A LL+ A RPV++ GT+VW AE A LR VE IP + NGM RGV Sbjct 185 RGAEPDSDAITEVAELLAAAARPVLILGTDVWADRAEEAALRFVEAVGIPTITNGMGRGV 244 Query 250 VPADHRLAFSRARSKALGEADVALIVGVPMDFRLG---FGGVFGSTTQLIVADRVEPARE 306 VP H L ++AR +ALG +D+ ++VG P+DFRLG FGG G+T +V P + Sbjct 245 VPGGHPLLVTKARGQALGGSDLVVVVGTPLDFRLGYGIFGGADGATPAQVVHVADSPGQL 304 Query 307 HPRP-VAAGLYGDLTATLSALAGSGGT-----DHQGWIEELATAETMARDLEKAELVDDR 360 +AA + GDL++ L + D GW+ +L A A + + A L + Sbjct 305 SGHAALAASVSGDLSSVFDGLLAAMEQVVRRPDWSGWVGDLGAAVAAAVERDAALLGAEA 364 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 P+HP R+Y +L L DA+V+ D GDF S+AG+ ++ PG WLD GP+GCLG+G G Sbjct 365 DPIHPARIYGDLVPRLAEDAVVIGDGGDFVSFAGKFVEPKRPGGWLDPGPYGCLGAGLGA 424 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 A+AA+LARP QVVLL GDGA GFS M+ DTLVRH++ VV V+GNN WGLEK PM+ LY Sbjct 425 AIAARLARPSAQVVLLLGDGAAGFSLMDVDTLVRHHLPVVMVMGNNSAWGLEKGPMQMLY 484 Query 481 GYSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAY 540 GY V+A+L P T YD+VVRALGG GE V+ P E+ PAL+RAFASG+P +VNV+TD + Y Sbjct 485 GYDVIADLAPRTAYDQVVRALGGAGETVTDPREVGPALDRAFASGVPYLVNVITDVTATY 544 Query 541 PRRS 544 PR S Sbjct 545 PRNS 548 >gi|72160957|ref|YP_288614.1| hypothetical protein Tfu_0553 [Thermobifida fusca YX] gi|71914689|gb|AAZ54591.1| acetolactate synthase large subunit [Thermobifida fusca YX] Length=553 Score = 456 bits (1174), Expect = 4e-126, Method: Compositional matrix adjust. Identities = 269/543 (50%), Positives = 338/543 (63%), Gaps = 11/543 (2%) Query 10 TMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEG--IRLIDTRHEQTAAFAAEGW 67 T H G + G+DT+FTLSGGH+F IYDG + +RL+D RHEQTA FAAE Sbjct 11 TGHGGNHAVEVARHHGVDTLFTLSGGHIFPIYDGAVKADPPMRLLDVRHEQTAVFAAEAV 70 Query 68 SKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPF 127 K+TR G AALTAGPG+TNG+S +A A N SPLVV+GGRAP RWG G LQE+D P Sbjct 71 GKLTRRAGWAALTAGPGVTNGVSGIATAHFNGSPLVVVGGRAPDNRWGQGLLQELDQSPL 130 Query 128 VAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTE 187 + + A T G +D+A A +A G F+D PMD + + A E Sbjct 131 FTTITKRAWTVHDTAQIGPALDEAFTLANTAHRGPVFLDIPMDRLYDQAEITVTGQAAAE 190 Query 188 LPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMAR 247 +P DA+ A LLS A+RPV++ G++VW HAE A L EE +PV+ NG R Sbjct 191 ---DRSPDPDAVAAVARLLSEAERPVLVYGSDVWLDHAEQAALEAAEELGVPVVTNGQGR 247 Query 248 GVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLG---FGGVFGSTTQLIVADRVEPA 304 GV+PA H L +RAR ALG AD+ ++VG P+DFRL FGG G+ V PA Sbjct 248 GVLPAGHPLLATRARGLALGRADLVIVVGTPLDFRLNHGLFGGRDGAPLARTVHITDSPA 307 Query 305 REHPRPVAAG-LYGDLTATLSALAGSGGTDHQ--GWIEELATAETMARDLEKAELVDDRI 361 + AG + GDL+A L ALA + W E+A A ++ L D Sbjct 308 QLATHLTLAGAVSGDLSAILRALAEQAKPKREVAQWRTEVAEAAAATAAKDREVLDSDAS 367 Query 362 PLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYA 421 P+HP R+Y EL +L+ DA+V+ D GDF SYAG+ I PG WLD GPFGCLG+G GYA Sbjct 368 PIHPARIYGELNRILDDDAVVIGDGGDFVSYAGKYIQPRRPGNWLDPGPFGCLGTGMGYA 427 Query 422 LAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYG 481 +AA+L RP QVV L GDGA GFS + DTLVRHN+ VV V GNNGIWGLEK PM+ +YG Sbjct 428 IAARLVRPSSQVVALFGDGALGFSLADVDTLVRHNLPVVMVCGNNGIWGLEKAPMQLVYG 487 Query 482 YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYP 541 Y V+A+L P TRYD+VV ALGG GELV+ PAE+ PAL RAF SG+P +VN++TDP YP Sbjct 488 YDVLADLAPQTRYDQVVTALGGGGELVTDPAEIGPALRRAFDSGVPYLVNIVTDPENVYP 547 Query 542 RRS 544 R++ Sbjct 548 RKT 550 >gi|319950475|ref|ZP_08024388.1| hypothetical protein ES5_12867 [Dietzia cinnamea P4] gi|319435834|gb|EFV91041.1| hypothetical protein ES5_12867 [Dietzia cinnamea P4] Length=573 Score = 454 bits (1169), Expect = 2e-125, Method: Compositional matrix adjust. Identities = 282/571 (50%), Positives = 351/571 (62%), Gaps = 42/571 (7%) Query 12 HAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREE--GIRLIDTRHEQTAAFAAEGWSK 69 H G A G+ T+FTLSG H+F +YD +E G+ L+D RHEQTAAFAAE K Sbjct 4 HGGSHATAVAAAHGVRTMFTLSGAHVFPMYDAAEKEDHGVALLDVRHEQTAAFAAEATGK 63 Query 70 VTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVA 129 +TR PG+A LTAGPG+TNG+SA+A A + +P+VVLGGRAPA RWG GSLQE DHVP V Sbjct 64 LTRSPGLAVLTAGPGVTNGVSALAQASFSGAPMVVLGGRAPAGRWGTGSLQEFDHVPVVQ 123 Query 130 PVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMS---------SDNG 180 V A TA+ + +A AA +A G AF+D MDH F +D+G Sbjct 124 SVTVSAETARDTADIAAATHRAFTAARTAHRGPAFLDVHMDHFFDRCNSARPGPGYTDDG 183 Query 181 RP-GALTE---------LPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALL 230 P GA+ + L A P DA+DR A LL A+RPV++ G++ W AE A L Sbjct 184 TPLGAVGDSDGAWPDRSLGADRLPDTDAVDRIADLLVRAERPVLVLGSDAWADGAEDAAL 243 Query 231 RLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFG 290 R VE +PV+ NGM RG++PA HRL +AR A G ADV ++VG P+DFRL +G VFG Sbjct 244 RCVETLGLPVIPNGMGRGILPAGHRLLVGKARGMAFGAADVVIVVGTPLDFRLSYG-VFG 302 Query 291 ST------TQLIVADRVEPAREHPRPVAAGLYGDLTATLSAL---------AGSGGTDHQ 335 T + +AD H P A GDL L AL G+G D Sbjct 303 GKEGAAPATVVHIADSPAQLSHHASPAVA-TAGDLELVLDALVESVDRRFRTGAGRPDWS 361 Query 336 GWIEELATAETMAR--DLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYA 393 GW L A DLE D P+HP R+Y EL L DA+V+ D GDF SYA Sbjct 362 GWATSLREKADAAHAADLELFSAAAD--PIHPARIYGELLPRLAEDAVVIGDGGDFVSYA 419 Query 394 GRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLV 453 G+ I+ PG WLD GPFGCLG+G G A+AA++ARP QVVLL GDGA GFS ++ DTLV Sbjct 420 GKFIEPARPGNWLDPGPFGCLGAGLGAAIAARIARPSSQVVLLLGDGAAGFSLIDVDTLV 479 Query 454 RHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRPGTRYDEVVRALGGHGELVSVPAE 513 RH + VV ++GNNG WGLEK PM+ LYGY V+A+L P TRYDEVVRALGG GE+V+ PA+ Sbjct 480 RHRLPVVMIMGNNGAWGLEKGPMQMLYGYDVIADLAPRTRYDEVVRALGGAGEMVTDPAQ 539 Query 514 LRPALERAFASGLPAVVNVLTDPSVAYPRRS 544 + PAL+RAFASG+P +VNV+TD YPR + Sbjct 540 IGPALDRAFASGVPYLVNVVTDVDAMYPRST 570 >gi|116747745|ref|YP_844432.1| thiamine pyrophosphate binding domain-containing protein [Syntrophobacter fumaroxidans MPOB] gi|116696809|gb|ABK15997.1| thiamine pyrophosphate enzyme TPP binding domain protein [Syntrophobacter fumaroxidans MPOB] Length=568 Score = 376 bits (965), Expect = 7e-102, Method: Compositional matrix adjust. Identities = 216/532 (41%), Positives = 306/532 (58%), Gaps = 9/532 (1%) Query 11 MHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV 70 + G+L+A+ L G+ +FTL G H+ IY GC +EGIR+ID RHEQTAA AA+ W+++ Sbjct 24 LTGGKLVAKTLATEGVQAIFTLCGAHVMDIYSGCLDEGIRIIDVRHEQTAAHAADAWTRL 83 Query 71 TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAP 130 T VPGVA +TAGPG+T+ ++ +A A + Q P++++GG+AP G LQE++ V + P Sbjct 84 TGVPGVAVVTAGPGVTDAVTGVANAYRAQVPMLLIGGQAPIRNLLKGGLQEMNSVDMMRP 143 Query 131 VARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG-RPGALTELP 189 + +F+ T ++ AL+ A + G +F++ P D +N R + Sbjct 144 ITKFSGTVFDTVRIPEMIGLALREACNGRPGPSFLEIPQDVLDREVEENEVRVPVQSRSQ 203 Query 190 AGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGV 249 T + RAAGLL+ AQRP ++AGT VW A L VE IP +NG ARG Sbjct 204 CRLTGDRKLMARAAGLLAKAQRPALIAGTQVWSCRAVEQLRLFVERAGIPTYLNGAARGC 263 Query 250 VPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPR 309 +P D AF+R R AL +ADV L++G P DFRLG+G ++I D H R Sbjct 264 LPVDSPHAFNRTRKFALSKADVVLVIGTPFDFRLGYGSRIAEGAKIIQVDLDYAELCHNR 323 Query 310 PVAAGLYGDLTATLSALAG----SGGTDHQGWIEELATAETMARDLEKAELVDDRIPLHP 365 V + D A L L G +GGT + W++EL T ET + E L D +P+HP Sbjct 324 DVEVAIQADAGAFLEELEGAVSPAGGT--RKWLDELRTMETELLERESRFLSSDAVPIHP 381 Query 366 MRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAK 425 +R+ E+ A L D++++ D GD + + +I PG WLD GP G LG G +A+AAK Sbjct 382 LRLAREIDAFLRDDSILIADGGDTVTMSASVIRPRGPGQWLDPGPLGTLGVGTPFAIAAK 441 Query 426 LARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYG--YS 483 A P R VV+L GDGAFG +G ++DTL+R N+ +V ++ NNG W ++ YG Sbjct 442 AAMPARDVVVLFGDGAFGLTGFDYDTLIRFNLPMVGIVANNGAWNQVRYVQLLKYGPQKG 501 Query 484 VVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTD 535 A L RYD ++ A+GGHGE V+ P E+R AL+RA SG PA VNVL D Sbjct 502 NTANLLHSLRYDRIIEAMGGHGEHVTEPGEIRAALDRARNSGKPACVNVLVD 553 >gi|297563047|ref|YP_003682021.1| thiamine pyrophosphate TPP binding domain-containing protein [Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] gi|296847495|gb|ADH69515.1| thiamine pyrophosphate protein TPP binding domain protein [Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length=568 Score = 372 bits (956), Expect = 8e-101, Method: Compositional matrix adjust. Identities = 212/548 (39%), Positives = 304/548 (56%), Gaps = 12/548 (2%) Query 10 TMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSK 69 T+ G L+A+ LKA GID +FTL GGH+ IYDGC +EGI ++D RHEQ AA AA+G+++ Sbjct 16 TISGGHLVAKALKAEGIDVIFTLCGGHIIDIYDGCADEGIDVVDVRHEQVAAHAADGYAR 75 Query 70 VTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVA 129 VT PG A +TAGPG T+ ++ +A A + +SP++V+GG+ + MGSLQ++ HV + Sbjct 76 VTGKPGCAVVTAGPGTTDAVTGIANAYRAESPMLVIGGQGALSQHKMGSLQDLPHVDMIN 135 Query 130 PVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMD-HAFSMSSDNGRPGALTEL 188 P+++FAAT E LV A + A S G AF++ P D + + R A Sbjct 136 PISKFAATVPHTERVADLVSMAFREANSGAPGPAFLEIPRDVLDAEVPVERARVPAKGRY 195 Query 189 PAGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMA 246 A AGD A++R A L+ +++P I+ G VW A + LV +IP MNG Sbjct 196 RASTRQAGDPAAIERLADLIVRSEKPSILLGNQVWTTRATQSATDLVRALNIPAYMNGAG 255 Query 247 RGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPARE 306 RG +P F +R A +D+ +IVG P DFR+G+G T ++ D Sbjct 256 RGTLPPGDPHHFQLSRRYAFTNSDLIIIVGTPFDFRMGYGKRLSPTATVVQIDLNYATVG 315 Query 307 HPRPVAAGLYGD----LTATLSALAG---SGGTDHQGWIEELATAETMARDLEKAELVDD 359 R V GL GD L++ L A +G +G + W+EEL T E A D L D Sbjct 316 KNRDVDLGLVGDADVILSSVLQATSGYGDNGAQSRKTWLEELRTQEQAALDKRAHLLTSD 375 Query 360 RIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPG 419 P+HP R+ +E+ L D++ V D GD +++G+++ PG W+D GP G LG G Sbjct 376 STPIHPYRLVSEINQFLTEDSIYVGDGGDIVTFSGQVVQPKSPGHWMDPGPLGTLGVGVP 435 Query 420 YALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEAL 479 + +AAK ARP ++VV L GDGAF +G +++TLVR ++ V ++GNN ++ A Sbjct 436 FVMAAKYARPDKEVVALFGDGAFSLTGWDFETLVRFDLPFVGIVGNNSSMNQIRYGQIAK 495 Query 480 YGYS--VVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPS 537 YG + Y E R LGGHGE V PA++ PAL RA SG P+++NV DP Sbjct 496 YGADRGEIGNTLGDVNYAEFARMLGGHGEEVRDPADIAPALRRARESGKPSLINVWIDPE 555 Query 538 VAYPRRSN 545 V P N Sbjct 556 VYAPGTMN 563 >gi|302557242|ref|ZP_07309584.1| TPP requiring enzyme [Streptomyces griseoflavus Tu4000] gi|302474860|gb|EFL37953.1| TPP requiring enzyme [Streptomyces griseoflavus Tu4000] Length=560 Score = 361 bits (927), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 208/562 (38%), Positives = 304/562 (55%), Gaps = 24/562 (4%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M DT + G L+A+ LKA G+D ++TL GGH+ IYDGC +EGI ++D RHEQ A Sbjct 1 MPDDTQ--DVISGGHLVAKALKAEGVDRIYTLCGGHIIDIYDGCVDEGIEVVDVRHEQVA 58 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 A AA+G++++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ Sbjct 59 AHAADGYARLTGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGALTQHKMGSLQ 118 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 ++ HV ++P+ +FAAT A +V A + G +F++ P D D Sbjct 119 DLPHVDMMSPITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRD-----VLDAK 173 Query 181 RPGALTELP------AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRL 232 P + +P A AGD A+++ A LL A+RP I+ G+ VW A + L Sbjct 174 VPASKARVPREGAYRASTRSAGDPEAIEKLADLLVHAERPAILLGSQVWTTRGTEAAVEL 233 Query 233 VEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGST 292 V +IP MNG RG +P F +R A ADV +IVG P DFR+G+G Sbjct 234 VRTLNIPAYMNGAGRGTLPPGDPHHFQLSRRYAFSHADVIVIVGTPFDFRMGYGKRLSPD 293 Query 293 TQLIVADRVEPAREHPRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAE 345 ++ D R + G+ GD +T S G + + W++EL AE Sbjct 294 ATVVQIDLDYRTVGKNRDIDLGVVGDAGLVLRSVTEAASGRVNGGASRRKEWLDELRAAE 353 Query 346 TMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCW 405 A D +L D P+HP R+ +E+ L D++ + D GD +++G+++ PG W Sbjct 354 QTALDKRLPQLRSDASPIHPYRLVSEINDFLTEDSVYIGDGGDIVTFSGQVVQPKSPGHW 413 Query 406 LDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGN 465 +D GP G LG G + LAAK ARP ++VV L GDGAF +G +++TLVR+++ V ++GN Sbjct 414 MDPGPLGTLGVGVPFVLAAKQARPDKEVVALFGDGAFSLTGWDFETLVRYDLPFVGIVGN 473 Query 466 NGIWGLEKHPMEALYGY--SVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFA 523 N ++ A YG V RYDE R LGGHGE V PA++ PAL RA Sbjct 474 NSSMNQIRYGQAAKYGKERERVGNTLGDVRYDEFARMLGGHGEEVRDPADIGPALRRARE 533 Query 524 SGLPAVVNVLTDPSVAYPRRSN 545 SG P++VNV DP P N Sbjct 534 SGKPSLVNVWVDPDAYAPGTMN 555 >gi|302555346|ref|ZP_07307688.1| acetolactate synthase, large subunit, biosynthetic type [Streptomyces viridochromogenes DSM 40736] gi|302472964|gb|EFL36057.1| acetolactate synthase, large subunit, biosynthetic type [Streptomyces viridochromogenes DSM 40736] Length=560 Score = 360 bits (924), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 207/562 (37%), Positives = 303/562 (54%), Gaps = 24/562 (4%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M DT + G L+A+ LKA G+D ++TL GGH+ IYDGC +EGI ++D RHEQ A Sbjct 1 MPDDTQ--DVISGGHLVAKALKAEGVDRIYTLCGGHIIDIYDGCVDEGIEVVDVRHEQVA 58 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 A AA+G++++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ Sbjct 59 AHAADGYARITGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGALTQHKMGSLQ 118 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 ++ HV + P+ +FAAT A LV A + G +F++ P D D Sbjct 119 DLPHVDMMNPITKFAATVPDTARAADLVSMAFRECYHGAPGPSFLEIPRD-----VLDAK 173 Query 181 RPGALTELP------AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRL 232 P A +P A AGD A++R A LL A++P I+ G+ VW A + L Sbjct 174 VPAAKARVPRAGAYRASTRSAGDPEAIERLADLLVHAEKPAILLGSQVWTTRGTGAAVEL 233 Query 233 VEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGST 292 V ++P MNG RG +P F +R A ADV +IVG P DFR+G+G Sbjct 234 VRTLNVPAYMNGAGRGTLPPGDPHHFQLSRRYAFSGADVIVIVGTPFDFRMGYGKRLSPE 293 Query 293 TQLIVADRVEPAREHPRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAE 345 ++ D R + G+ GD +T S G + + W++EL AE Sbjct 294 ATVVQIDLDYRTVGKNRDIDLGIVGDAGLVLKAVTEAASGRVNGGASRRKEWLDELRAAE 353 Query 346 TMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCW 405 A + +L D P+HP R+ +E+ L D++ + D GD +++G+++ PG W Sbjct 354 QTALEKRLPQLRSDASPIHPYRLVSEINDFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHW 413 Query 406 LDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGN 465 +D GP G LG G + LAAK ARP ++VV L GDGAF +G +++TLVR+++ V ++GN Sbjct 414 MDPGPLGTLGVGVPFVLAAKQARPDKEVVALFGDGAFSLTGWDFETLVRYDLPFVGIVGN 473 Query 466 NGIWGLEKHPMEALYGYS--VVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFA 523 N ++ A YG V RYDE R LGGHGE V PA++ PAL RA Sbjct 474 NSSMNQIRYGQAAKYGKDRERVGNTLGDVRYDEFARMLGGHGEEVRDPADIGPALRRARE 533 Query 524 SGLPAVVNVLTDPSVAYPRRSN 545 SG P+++NV DP P N Sbjct 534 SGKPSLINVWVDPDAYAPGTMN 555 >gi|297190798|ref|ZP_06908196.1| TPP-requiring enzyme [Streptomyces pristinaespiralis ATCC 25486] gi|197722579|gb|EDY66487.1| TPP-requiring enzyme [Streptomyces pristinaespiralis ATCC 25486] Length=561 Score = 360 bits (923), Expect = 4e-97, Method: Compositional matrix adjust. Identities = 201/554 (37%), Positives = 300/554 (55%), Gaps = 12/554 (2%) Query 4 DTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFA 63 D Q + G L+A+ LKA G++ ++TL GGH+ IYDGC +EGI ++D RHEQ AA A Sbjct 3 DDNSQQLISGGHLVAKALKAEGVEVIYTLCGGHIIDIYDGCVDEGIEVVDVRHEQVAAHA 62 Query 64 AEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEID 123 A+G++++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ Sbjct 63 ADGYARITGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHTQHKMGSLQDLP 122 Query 124 HVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMD-HAFSMSSDNGRP 182 HV + P+ +FAAT A +V A + G +F++ P D + + R Sbjct 123 HVDMMTPITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRDVLDAKVPVEKARV 182 Query 183 GALTELPAGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 A AGD A+++ A LL A++P I+ G+ VW + + LV ++P Sbjct 183 PKAGHYRASTRSAGDPEAVEKLADLLVHAEKPAILLGSQVWTTRGTDSAVELVRTLNMPA 242 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 MNG RG +P F +R A ADV +IVG P DFR+G+G ++ D Sbjct 243 YMNGAGRGTLPPGDPHHFQLSRRYAFAGADVIVIVGTPFDFRMGYGKRLSPAATVVQIDL 302 Query 301 VEPAREHPRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAETMARDLEK 353 R + G+ GD +T +S G + W+EEL AE A D Sbjct 303 DYRTVGKNRDIDLGIVGDAGLILKSVTEAVSGRLNGGAVKRKAWLEELRAAEQTALDKRL 362 Query 354 AELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGC 413 +L D P+HP R+ +E+ L D++ + D GD +++G+++ PG W+D GP G Sbjct 363 PQLRSDASPIHPYRLVSEINDFLTEDSVYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGT 422 Query 414 LGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEK 473 LG G + LAAK ARP ++VV L GDGAF +G +++TLVR+N+ V ++GNN + Sbjct 423 LGVGVPFVLAAKQARPDKEVVALFGDGAFSLTGWDFETLVRYNLPFVGIVGNNSSMNQIR 482 Query 474 HPMEALYGY--SVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVN 531 + YG V RYDE R LGG+GE V PA++ PAL RA SGLP+++N Sbjct 483 YGQAQKYGLERERVGNTLGDVRYDEFARMLGGYGEEVRDPADIAPALRRARESGLPSLIN 542 Query 532 VLTDPSVAYPRRSN 545 V DP P N Sbjct 543 VWVDPDAYAPGTMN 556 >gi|291436090|ref|ZP_06575480.1| TPP-requiring enzyme [Streptomyces ghanaensis ATCC 14672] gi|291338985|gb|EFE65941.1| TPP-requiring enzyme [Streptomyces ghanaensis ATCC 14672] Length=560 Score = 358 bits (920), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 206/562 (37%), Positives = 302/562 (54%), Gaps = 24/562 (4%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M DT + G L+A+ LKA G+D ++TL GGH+ IYDGC +EGI ++D RHEQ A Sbjct 1 MPDDTQ--DVISGGHLVAKALKAEGVDRIYTLCGGHIIDIYDGCVDEGIEVVDVRHEQVA 58 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 A AA+G+++VT PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ Sbjct 59 AHAADGYARVTGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGALTQHKMGSLQ 118 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 ++ HV + P+ +FAAT A +V A + G +F++ P D D Sbjct 119 DLPHVDMMNPITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRD-----VLDAK 173 Query 181 RPGALTELP------AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRL 232 P + +P A AGD A++R A LL A++P ++ G+ VW A + L Sbjct 174 VPASSARVPRQGAYRASTRSAGDPEAIERLADLLVHAEKPAVLLGSQVWTTRGTEAAVDL 233 Query 233 VEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGST 292 V +P MNG RG +P F +R A ADV +IVG P DFR+G+G Sbjct 234 VRTLDVPAYMNGAGRGTLPPGDPHHFQLSRRYAFSHADVIVIVGTPFDFRMGYGKRLSPN 293 Query 293 TQLIVADRVEPAREHPRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAE 345 ++ D R + G+ GD +T S G + + W+EEL AE Sbjct 294 ATVVQIDLDYRTVGKNRDIDLGIVGDAGLVLKSVTEAASGRIDGGASRRKEWLEELRAAE 353 Query 346 TMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCW 405 A D +L + P+HP R+ +E+ L D++ + D GD +++G+++ PG W Sbjct 354 RTALDKRLPQLRSNASPIHPYRLVSEINDFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHW 413 Query 406 LDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGN 465 +D GP G LG G + LAAK ARP ++VV L GDGAF +G +++TLVR+++ V ++GN Sbjct 414 MDPGPLGTLGVGVPFVLAAKQARPDKEVVALFGDGAFSLTGWDFETLVRYDLPFVGIVGN 473 Query 466 NGIWGLEKHPMEALYGY--SVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFA 523 N ++ A YG V RYDE R LGGHGE V PA++ PAL RA Sbjct 474 NSSMNQIRYGQAAKYGKERERVGNTLGDVRYDEFARMLGGHGEEVRDPADIGPALRRARE 533 Query 524 SGLPAVVNVLTDPSVAYPRRSN 545 SG P+++NV DP P N Sbjct 534 SGKPSLINVWVDPDAYAPGTMN 555 >gi|284030091|ref|YP_003380022.1| thiamine pyrophosphate protein TPP binding domain-containing protein [Kribbella flavida DSM 17836] gi|283809384|gb|ADB31223.1| thiamine pyrophosphate protein TPP binding domain protein [Kribbella flavida DSM 17836] Length=574 Score = 358 bits (920), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 203/554 (37%), Positives = 302/554 (55%), Gaps = 21/554 (3%) Query 8 AQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGW 67 A T+ G L+A+ LKA GID +FTL GGH+ IYDGC +EGI ++D RHEQ AA AA+G+ Sbjct 21 AATISGGHLVAKALKAEGIDVIFTLCGGHIIDIYDGCVDEGIAVVDVRHEQVAAHAADGY 80 Query 68 SKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPF 127 +++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV Sbjct 81 ARMTGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGALNQHKMGSLQDLPHVDM 140 Query 128 VAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTE 187 + P+ +FAAT +V A + + G +F++ P D DN P Sbjct 141 MTPITKFAATVPHTARVADMVSMAFRECYNGAPGPSFLEIPRD-----ILDNSVPVEAAT 195 Query 188 LP------AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIP 239 +P A GD ++ A LL+ A++PV++ GT VW A + V E ++P Sbjct 196 VPEAGRYRASTKSIGDPAGIEALADLLARAEKPVVLLGTQVWTSRGSDAAIEFVRENNVP 255 Query 240 VLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVAD 299 MNG ARG +P F +R AD+ LIVG P DFR+G+G ++ D Sbjct 256 AFMNGSARGTLPPGDPHHFHLSRRYGFNNADLILIVGTPFDFRMGYGRRLPQGATVVQID 315 Query 300 RVEPAREHPRPVAAGLYGDLTATLSAL--AGSG----GTDHQGWIEELATAETMARDLEK 353 R + GL GD A L+A+ A SG D + W EL E A Sbjct 316 MDYRTVGKNRDIDLGLVGDPGAILAAVTQAASGRVRKAGDRKAWFAELRAEEDAAYQKRL 375 Query 354 AELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGC 413 + + D P+HP+R+ E+ L D++ + D GD +++G ++ PG W+D GP G Sbjct 376 PKQLSDANPIHPLRLAHEINEFLTEDSIYIGDGGDIVTFSGGVVQPKSPGHWMDPGPLGT 435 Query 414 LGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEK 473 +G G + +AAK ARP ++VV L GDGAF +G +++TLVR N+ V V+GNN + Sbjct 436 IGVGIPFVMAAKYARPDKEVVALFGDGAFSLTGWDFETLVRFNLPFVGVVGNNSSMNQIR 495 Query 474 HPMEALYGYS--VVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVN 531 + EA YG+ + +YDE + LGG+GE V P ++ PA++RA SGLP+++N Sbjct 496 YGQEAKYGHDRGRIGNTLGDVKYDEFAKMLGGYGEEVRDPKDIGPAMQRARESGLPSLIN 555 Query 532 VLTDPSVAYPRRSN 545 V DP P N Sbjct 556 VWVDPDAYAPGTMN 569 >gi|300786452|ref|YP_003766743.1| acetolactate synthase I/II/III large subunit [Amycolatopsis mediterranei U32] gi|299795966|gb|ADJ46341.1| acetolactate synthase I/II/III large subunit [Amycolatopsis mediterranei U32] Length=578 Score = 356 bits (914), Expect = 6e-96, Method: Compositional matrix adjust. Identities = 208/551 (38%), Positives = 298/551 (55%), Gaps = 12/551 (2%) Query 7 PAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEG 66 P + G L+A+ LKA G+DT+FTL GGH+ IYDGC +EGI +ID RHEQ AA AA+G Sbjct 23 PPAGISGGHLVAKALKAEGVDTIFTLCGGHIIDIYDGCVDEGIEVIDVRHEQVAAHAADG 82 Query 67 WSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVP 126 ++++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV Sbjct 83 YARITGKPGCAVVTAGPGTTDAVTGIANALRAESPMLLIGGQGALTQHKMGSLQDLPHVD 142 Query 127 FVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFS-MSSDNGRPGAL 185 + P+ +FAAT LV A + A + G +F++ P D + + + R Sbjct 143 MMTPITKFAATVPHTARVADLVSMAFREAYAGAPGPSFLEIPRDVLDARVPLEQARIPEA 202 Query 186 TELPAGPTPAGDALD--RAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMN 243 A AGD D + A LL A++P I+ G+ VW A LV +IP MN Sbjct 203 GRYRASTKNAGDPADVEKLADLLVHAKKPAILLGSQVWTTRATGPATELVRTLNIPAYMN 262 Query 244 GMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEP 303 G RG +P F +R A ADV +IVG P DFR+G+G ++ D Sbjct 263 GAGRGTLPPGDPHHFQLSRRYAFDNADVIVIVGTPFDFRMGYGKRLSKDAAVVQIDLDYR 322 Query 304 AREHPRPVAAGLYGDLTATLSAL--AGSGGTDH-----QGWIEELATAETMARDLEKAEL 356 R + G+ GD L+A+ A SG TD+ + W+EEL E A+ Sbjct 323 TVGKNRDIDLGIVGDAGQVLAAVAEAASGRTDNGAVGRKAWLEELQAVEEKAKQKRLPLQ 382 Query 357 VDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGS 416 D P+HP R+ E+ L D++ + D GD +++G+++ PG W+D GP G LG Sbjct 383 HSDARPIHPYRLVHEINEFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGTLGV 442 Query 417 GPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPM 476 G + LAAK ARP VV L GDGAF +G +++TLVR ++ V ++GNN ++ Sbjct 443 GIPFVLAAKHARPDADVVALFGDGAFSLTGWDFETLVRFDLPFVGIVGNNSSMNQIRYGQ 502 Query 477 EALYGY--SVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLT 534 + YG V RYDE R LGGHGE V PA++ PAL RA SG P+++NV Sbjct 503 ASKYGLPRERVGNTLGDVRYDEFARMLGGHGEEVRDPADIGPALLRARESGKPSLINVWV 562 Query 535 DPSVAYPRRSN 545 DP V P N Sbjct 563 DPDVYAPGTMN 573 >gi|21224884|ref|NP_630663.1| TPP-requiring enzyme [Streptomyces coelicolor A3(2)] gi|289767832|ref|ZP_06527210.1| TPP-requiring enzyme [Streptomyces lividans TK24] gi|3288605|emb|CAA19777.1| putative TPP-requiring enzyme [Streptomyces coelicolor A3(2)] gi|289698031|gb|EFD65460.1| TPP-requiring enzyme [Streptomyces lividans TK24] Length=560 Score = 356 bits (913), Expect = 7e-96, Method: Compositional matrix adjust. Identities = 204/562 (37%), Positives = 300/562 (54%), Gaps = 24/562 (4%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M DT + G L+A+ LKA G+D ++TL GGH+ IYDGC +EGI ++D RHEQ A Sbjct 1 MPDDTQ--DVISGGHLVAKALKAEGVDRIYTLCGGHIIDIYDGCVDEGIEVVDVRHEQVA 58 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 A AA+G++++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ Sbjct 59 AHAADGYARITGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHTQHKMGSLQ 118 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 ++ HV + P+ +FAAT A +V A + G +F++ P D D Sbjct 119 DLPHVDMMTPITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRD-----VLDAK 173 Query 181 RPGALTELP------AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRL 232 P +P A AGD A++R A LL A++P ++ G+ VW A A + L Sbjct 174 VPAEKARVPRAGGYRASTRSAGDPEAVERLADLLVHAEKPAVLLGSQVWTTRATEAAVEL 233 Query 233 VEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGST 292 V ++P MNG RG +P F +R A ADV +IVG P DFR+G+G Sbjct 234 VRTLNVPAYMNGAGRGTLPPGDPHHFQLSRRYAFSNADVIVIVGTPFDFRMGYGKRLSPD 293 Query 293 TQLIVADRVEPAREHPRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAE 345 ++ D R + G+ GD +T S G + W++EL AE Sbjct 294 ATVVQIDLDYRTVGKNRDIDLGIVGDAGLVLKSVTEAASGRINGGAAKRKEWLDELRAAE 353 Query 346 TMARDLEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCW 405 A D +L D P+HP R+ +E+ L D++ + D GD +++G+++ PG W Sbjct 354 RTALDKRLPQLRSDASPIHPYRLVSEINDFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHW 413 Query 406 LDSGPFGCLGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGN 465 +D GP G LG G + LAAK ARP ++VV L GDGAF +G +++TLVR+++ V ++GN Sbjct 414 MDPGPLGTLGVGVPFVLAAKQARPDKEVVALFGDGAFSLTGWDFETLVRYDLPFVGIVGN 473 Query 466 NGIWGLEKHPMEALYGY--SVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFA 523 N ++ YG V YDE R LGGHGE V PA++ PAL RA Sbjct 474 NSSMNQIRYGQAVKYGKERERVGNTLGDVPYDEFARMLGGHGEEVRDPADIGPALRRARE 533 Query 524 SGLPAVVNVLTDPSVAYPRRSN 545 SG P+++NV DP P N Sbjct 534 SGKPSLINVWVDPDAYAPGTMN 555 >gi|297156123|gb|ADI05835.1| putative TPP-requiring protein [Streptomyces bingchenggensis BCW-1] Length=560 Score = 354 bits (908), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 202/554 (37%), Positives = 302/554 (55%), Gaps = 22/554 (3%) Query 9 QTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWS 68 + + G L+A+ LKA G+D ++TL GGH+ IYDGC +EGI +ID RHEQ AA AA+G++ Sbjct 7 ELISGGHLVAKALKAEGVDVIYTLCGGHIIDIYDGCVDEGIDVIDVRHEQVAAHAADGYA 66 Query 69 KVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFV 128 ++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV + Sbjct 67 RITGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHTQHKMGSLQDLPHVDMM 126 Query 129 APVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTEL 188 AP+ +FAAT A +V A + G +F++ P D D P A + Sbjct 127 APITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRD-----VLDAKVPVAGARI 181 Query 189 P------AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 P A AGD A+++ A LL A++P I+ G+ VW A A + LV ++P Sbjct 182 PEAGKYRASNRSAGDPEAVEKLADLLVRAEKPAILLGSQVWTCRATDAAIELVRTLNVPA 241 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 MNG RG +P F +R A AD+ +IVG P DFR+G+G ++ D Sbjct 242 YMNGAGRGTLPPGDPHHFQLSRRYAFSNADLIVIVGTPFDFRMGYGKRLSPDATVVQIDL 301 Query 301 VEPAREHPRPVAAGLYGDLTATLSALA-------GSGGTDHQGWIEELATAETMARDLEK 353 R + G+ GD LSA+ G + W++EL AE A + Sbjct 302 DYRTVGKNRDIDLGIVGDAGLVLSAVTQAASGRINGGAGRRKEWLDELRAAEQTAIEKRL 361 Query 354 AELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGC 413 +L D P+HP R+ +E+ L D++ + D GD +++G+++ PG W+D GP G Sbjct 362 PQLRSDASPIHPYRLVSEINDFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGT 421 Query 414 LGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEK 473 LG G + +AAK ARP ++VV L GDGAF +G +++TLVR N+ V ++GNN + Sbjct 422 LGVGVPFVMAAKQARPDKEVVALFGDGAFSLTGWDFETLVRFNLPFVGIVGNNSSMNQIR 481 Query 474 HPMEALYG--YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVN 531 + +A YG V YD+ R LGG+GE V PA++ PAL RA SG P+++N Sbjct 482 YGQKAKYGEERQRVGNTLGDVPYDQFARMLGGYGEEVRDPADIAPALRRARESGKPSLIN 541 Query 532 VLTDPSVAYPRRSN 545 V DP P N Sbjct 542 VWVDPDAYAPGTMN 555 >gi|302541482|ref|ZP_07293824.1| TPP requiring enzyme [Streptomyces hygroscopicus ATCC 53653] gi|302459100|gb|EFL22193.1| TPP requiring enzyme [Streptomyces himastatinicus ATCC 53653] Length=560 Score = 352 bits (903), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 199/547 (37%), Positives = 297/547 (55%), Gaps = 12/547 (2%) Query 11 MHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV 70 + G L+A+ LKA G+D ++TL GGH+ IYDGC +EGI +ID RHEQ AA AA+G +++ Sbjct 9 ISGGHLVAKALKAEGVDVIYTLCGGHIIDIYDGCVDEGIDVIDVRHEQVAAHAADGHARI 68 Query 71 TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAP 130 T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV +AP Sbjct 69 TGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHTQHKMGSLQDLPHVDMMAP 128 Query 131 VARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMD-HAFSMSSDNGRPGALTELP 189 + +FAAT A +V A + G +F++ P D + + R Sbjct 129 ITKFAATVPDTARAADMVSMAFRECFHGAPGPSFLEIPRDVLDAKVPVEKARVPKAGAYR 188 Query 190 AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMAR 247 A AGD A+++ A LL A++P I+ G+ VW A A LV ++P MNG R Sbjct 189 ASTRSAGDPEAVEKLADLLVHAEKPAILLGSQVWTCRATDAATELVRTLNVPAYMNGAGR 248 Query 248 GVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREH 307 G +P F +R A AD+ +IVG P DFR+G+G ++ D Sbjct 249 GTLPPGDPHHFQLSRRYAFSNADLIVIVGTPFDFRMGYGKRLSPDATVVQIDLDYRTVGK 308 Query 308 PRPVAAGLYGDLTATLSALA-------GSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 R + G+ GD LSA+ G + W++EL AE A + +L D Sbjct 309 NRDIDLGIVGDSHQILSAVTQAASGRLNGGARQRKEWLDELRAAEQKAIEKRLPQLRSDA 368 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 P+HP R+ +E+ L D++ + D GD +++G+++ PG W+D GP G LG G + Sbjct 369 SPIHPYRLVSEINDFLTEDSIYIGDGGDIVTFSGQVVQPRTPGHWMDPGPLGTLGVGVPF 428 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 +AAK ARP ++VV L GDGAF +G +++TLVR N+ V ++GNN ++ +A Y Sbjct 429 VMAAKQARPDKEVVALFGDGAFSLTGWDFETLVRFNLPFVGIVGNNSSMNQIRYGQKAKY 488 Query 481 G--YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSV 538 G + YD+ R LGG+GE V PAE+ PAL RA SG P+++NV DP Sbjct 489 GEPRERIGNTLGDVPYDQFARMLGGYGEEVRDPAEIAPALRRARESGKPSLINVWVDPDA 548 Query 539 AYPRRSN 545 P N Sbjct 549 YAPGTMN 555 >gi|345010283|ref|YP_004812637.1| thiamine pyrophosphate TPP-binding domain-containing protein [Streptomyces violaceusniger Tu 4113] gi|344036632|gb|AEM82357.1| thiamine pyrophosphate TPP-binding domain-containing protein [Streptomyces violaceusniger Tu 4113] Length=560 Score = 351 bits (901), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 197/547 (37%), Positives = 297/547 (55%), Gaps = 12/547 (2%) Query 11 MHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV 70 + G L+A+ LKA G++ ++TL GGH+ IYDGC +EGI +ID RHEQ AA AA+G++++ Sbjct 9 ISGGHLVAKALKAEGVEVIYTLCGGHIIDIYDGCVDEGIDVIDVRHEQVAAHAADGYARI 68 Query 71 TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAP 130 T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV +AP Sbjct 69 TGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHNQHKMGSLQDLPHVDMMAP 128 Query 131 VARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMD-HAFSMSSDNGRPGALTELP 189 + +FAAT A +V A + G +F++ P D + D R Sbjct 129 ITKFAATVPDTARAADMVSMAFRECFHGAPGPSFLEIPRDVLDAKVPVDKARIPQAGHYR 188 Query 190 AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMAR 247 A AGD ++ + A LL A++P I+ G+ VW A A + LV ++P MNG R Sbjct 189 ASTRSAGDPESVQKLADLLVQAEKPAILLGSQVWTTRATDAAIELVRTLNVPAYMNGAGR 248 Query 248 GVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREH 307 G +P F +R A AD+ +IVG P DFR+G+G ++ D Sbjct 249 GTLPPGDPHHFQLSRRYAFSNADLIVIVGTPFDFRMGYGKRLSPDATVVQIDLDYRTVGK 308 Query 308 PRPVAAGLYGDLTATLSALA-------GSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 R + G+ GD LSA+ G + W++EL AE A + L D Sbjct 309 NRDIDLGIVGDAGLVLSAVTQAASGRINGGAGKRKEWLDELRAAEQKAIEKRLPNLRSDA 368 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 P+HP R+ +E+ L D++ + D GD +++G+++ PG W+D GP G LG G + Sbjct 369 SPIHPYRLVSEINDFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGTLGVGVPF 428 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 +AAK ARP ++VV L GDGAF +G +++TLVR ++ V ++GNN ++ +A Y Sbjct 429 VMAAKQARPDKEVVALFGDGAFSLTGWDFETLVRFDLPFVGIVGNNSSMNQIRYGQKAKY 488 Query 481 G--YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSV 538 G + YD+ R LGGHGE V PA++ PAL RA SG P+++NV DP Sbjct 489 GEERERIGNTLGDVPYDQFARMLGGHGEEVRDPADIGPALRRARESGKPSLINVWVDPDA 548 Query 539 AYPRRSN 545 P N Sbjct 549 YAPGTMN 555 >gi|340527930|gb|AEK43135.1| acetolactate synthase I/II/III large subunit [Amycolatopsis mediterranei S699] Length=546 Score = 351 bits (901), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 205/541 (38%), Positives = 294/541 (55%), Gaps = 12/541 (2%) Query 17 IARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGV 76 +A+ LKA G+DT+FTL GGH+ IYDGC +EGI +ID RHEQ AA AA+G++++T PG Sbjct 1 MAKALKAEGVDTIFTLCGGHIIDIYDGCVDEGIEVIDVRHEQVAAHAADGYARITGKPGC 60 Query 77 AALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAA 136 A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV + P+ +FAA Sbjct 61 AVVTAGPGTTDAVTGIANALRAESPMLLIGGQGALTQHKMGSLQDLPHVDMMTPITKFAA 120 Query 137 TAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFS-MSSDNGRPGALTELPAGPTPA 195 T LV A + A + G +F++ P D + + + R A A Sbjct 121 TVPHTARVADLVSMAFREAYAGAPGPSFLEIPRDVLDARVPLEQARIPEAGRYRASTKNA 180 Query 196 GDALD--RAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPAD 253 GD D + A LL A++P I+ G+ VW A LV +IP MNG RG +P Sbjct 181 GDPADVEKLADLLVHAKKPAILLGSQVWTTRATGPATELVRTLNIPAYMNGAGRGTLPPG 240 Query 254 HRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHPRPVAA 313 F +R A ADV +IVG P DFR+G+G ++ D R + Sbjct 241 DPHHFQLSRRYAFDNADVIVIVGTPFDFRMGYGKRLSKDAAVVQIDLDYRTVGKNRDIDL 300 Query 314 GLYGDLTATLSAL--AGSGGTDH-----QGWIEELATAETMARDLEKAELVDDRIPLHPM 366 G+ GD L+A+ A SG TD+ + W+EEL E A+ D P+HP Sbjct 301 GIVGDAGQVLAAVAEAASGRTDNGAVGRKAWLEELQAVEEKAKQKRLPLQHSDARPIHPY 360 Query 367 RVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAAKL 426 R+ E+ L D++ + D GD +++G+++ PG W+D GP G LG G + LAAK Sbjct 361 RLVHEINEFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGTLGVGIPFVLAAKH 420 Query 427 ARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGY--SV 484 ARP VV L GDGAF +G +++TLVR ++ V ++GNN ++ + YG Sbjct 421 ARPDADVVALFGDGAFSLTGWDFETLVRFDLPFVGIVGNNSSMNQIRYGQASKYGLPRER 480 Query 485 VAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRS 544 V RYDE R LGGHGE V PA++ PAL RA SG P+++NV DP V P Sbjct 481 VGNTLGDVRYDEFARMLGGHGEEVRDPADIGPALLRARESGKPSLINVWVDPDVYAPGTM 540 Query 545 N 545 N Sbjct 541 N 541 >gi|290956176|ref|YP_003487358.1| TPP-requiring protein [Streptomyces scabiei 87.22] gi|260645702|emb|CBG68793.1| putative TPP-requiring enzyme [Streptomyces scabiei 87.22] Length=561 Score = 348 bits (894), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 195/554 (36%), Positives = 300/554 (55%), Gaps = 12/554 (2%) Query 4 DTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFA 63 D + + G L+A+ LKA G++ ++TL GGH+ IYDGC +EGI ++D RHEQ AA A Sbjct 3 DGNSQELISGGHLVAKALKAEGVEVIYTLCGGHIIDIYDGCVDEGIEVVDVRHEQVAAHA 62 Query 64 AEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEID 123 A+G++++T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ Sbjct 63 ADGYARITGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHTQHKMGSLQDLP 122 Query 124 HVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMD-HAFSMSSDNGRP 182 HV + P+ +FAAT A +V A + G +F++ P D + + R Sbjct 123 HVDMMTPITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRDVLDAKVPVEKARV 182 Query 183 GALTELPAGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPV 240 A AGD A+++ A LL A++P I+ G+ VW + + LV +IP Sbjct 183 PKAGAYRASTRSAGDPEAVEKLADLLVHAEKPAILLGSQVWTTRGTESAIDLVRTLNIPA 242 Query 241 LMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADR 300 MNG RG +P F +R A ADV +IVG P DFR+G+G ++ D Sbjct 243 YMNGAGRGTLPPGDPHHFQLSRRYAFSNADVIVIVGTPFDFRMGYGKRLSPDATVVQIDL 302 Query 301 VEPAREHPRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAETMARDLEK 353 R + G+ GD +T S G + + W++EL AE A + Sbjct 303 DYRTVGKNRDIDLGIVGDAGLVLKSVTEAASGRINGGASRRKEWLDELRAAEQTAIEKRL 362 Query 354 AELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGC 413 L D P+HP R+ +E+ L D++ + D GD +++G+++ PG W+D GP G Sbjct 363 PSLRSDASPIHPYRLVSEINEFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGT 422 Query 414 LGSGPGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEK 473 LG G + LAAK ARP ++VV L GDGAF +G +++TLVR+++ V +IGNN + Sbjct 423 LGVGVPFVLAAKKARPDKEVVALFGDGAFSLTGWDFETLVRYDLPFVGIIGNNSSMNQIR 482 Query 474 HPMEALYG--YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVN 531 + +A YG + YD+ + LGG+GE V PA++ PAL+RA SG P+++N Sbjct 483 YGQKAKYGEERERIGNTLGDVHYDKFAQMLGGYGEEVRDPADIGPALQRARESGKPSLIN 542 Query 532 VLTDPSVAYPRRSN 545 V DP P N Sbjct 543 VWVDPDAYAPGTMN 556 >gi|153003956|ref|YP_001378281.1| thiamine pyrophosphate protein central region [Anaeromyxobacter sp. Fw109-5] gi|152027529|gb|ABS25297.1| thiamine pyrophosphate protein central region [Anaeromyxobacter sp. Fw109-5] Length=550 Score = 348 bits (893), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 215/539 (40%), Positives = 303/539 (57%), Gaps = 12/539 (2%) Query 9 QTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWS 68 +T+ GRL+AR L+ G+ T FTLSG H+ IY GC +EGIRL+DTRHEQ AA AA+ W+ Sbjct 2 ETLTGGRLVARMLRKEGVTTAFTLSGLHVAPIYAGCVDEGIRLVDTRHEQAAAHAADAWA 61 Query 69 KVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFV 128 ++TR GVA +TAGPG+T+ ++ +A A PLV+LGG AP+ G GSLQE+ V Sbjct 62 RLTRGVGVAIVTAGPGVTDAVTGVANAWAANVPLVLLGGAAPSFNQGRGSLQEMPQVQLF 121 Query 129 APVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTEL 188 A + +++ S E + +A + A + G F++ P D S +D A Sbjct 122 AGITKWSDRIPSPELVPSFLAKAFRVARAGRPGPVFLEIPWD-VLSNGADEALAEAQASY 180 Query 189 PAGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMA 246 GD ++ A LL+ A+RPV++ G++VWW AL RL + IPV +NGM Sbjct 181 RTDARMPGDPRKIEEALALLARAERPVLLGGSSVWWDGGVDALARLADRTGIPVYLNGMG 240 Query 247 RGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGG--VFGSTTQLIVADRVEPA 304 RG +P DH A +R +AL +ADV ++VG P+DFR+G+G F +++ D Sbjct 241 RGCLPPDHPSALQLSRKEALAQADVVVVVGTPLDFRVGYGTEPTFAPGARVVQVDVDGAE 300 Query 305 REHPRPVAAGLYGDLTATLSALAGSG--GTDHQGWIEELATAETMARDLEKAELVDDRIP 362 RP+ G+ GD + L L + W L ET + ++ D+ P Sbjct 301 IGRNRPIDVGIVGDARSVLEQLEAGARLAPAAEAWRAFLRQQETSRAEKQRGYEESDQRP 360 Query 363 LHPMRVYAELAALLER--DALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 +H R+ L + R D V D G+ + A +++ PG WLD GP GCLG G + Sbjct 361 IHHFRLAKALDTVASRAGDVTFVGDGGNVVAVAAKVLKVKKPGRWLDPGPLGCLGVGAPF 420 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 A+AAKL P+R V ++QGDGAFG +G +++T VR + +V V+GN+ WG P LY Sbjct 421 AIAAKLLAPERPVCVIQGDGAFGLNGFDFETAVRFGLPMVVVVGNDAAWGQILVPQRGLY 480 Query 481 G--YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPS 537 G ++V +L P TRYD VV A GG GE V PA+L PALERAFASG V+V DP Sbjct 481 GDDHAVATKLAP-TRYDRVVEAFGGEGEHVEDPADLVPALERAFASGTVYCVDVAIDPE 538 >gi|162456410|ref|YP_001618777.1| acetolactate synthase [Sorangium cellulosum 'So ce 56'] gi|161166992|emb|CAN98297.1| putative Acetolactate synthase [Sorangium cellulosum 'So ce 56'] Length=546 Score = 348 bits (893), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 211/529 (40%), Positives = 300/529 (57%), Gaps = 5/529 (0%) Query 7 PAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEG 66 P +H GRL+++ L G+ +FTL GGH+ +IYDGC ++GIR++D RHEQTA AA+G Sbjct 6 PMAQVHGGRLVSKALARHGVTHLFTLCGGHIQAIYDGCLDDGIRVVDVRHEQTAGHAADG 65 Query 67 WSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVP 126 +++VT PGV A+TAGPG+T+ ++A+A AQ+ P+VVLGG P MGSLQ+++HV Sbjct 66 YARVTGRPGVCAVTAGPGVTDVVTAVANAQRAGVPMVVLGGAGPRALADMGSLQDMNHVE 125 Query 127 FVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDN-GRPGAL 185 + P+++++ + S + VD A + A + G F++ P+D + + D+ Sbjct 126 LMRPISKWSVSVPSTDRIQEYVDSAFRVAQANVPGPVFLEMPLDLLMNYAGDDAPATAPA 185 Query 186 TELPAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGM 245 G PA A+ RAA LL A+RP+ + G+ + W AL R + P +NGM Sbjct 186 APPRPGGDPA--AVARAAALLRDAERPMFIVGSQLRWSPRRDALRRFADAVRAPFYLNGM 243 Query 246 ARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAR 305 ARG +P H SR+R AL + D+ +++G P DFRL +G T +++ D Sbjct 244 ARGALPHAHPGLMSRSRRFALSQTDLCVVLGTPFDFRLEYGRAISPTAKVVQIDLDGSEL 303 Query 306 EHPRPVAAGLYGDLTATLSA-LAGSGGTDHQGWIEELATAETMARDLEKAELVDDRIPLH 364 R V G+ GD L LA W+ + AE +R AE+ D P + Sbjct 304 GKNRRVDVGIDGDSGVVLEQLLAEVPDKTAAAWLSAVREAEERSRAKMLAEIASDGDPPN 363 Query 365 PMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGYALAA 424 P+RV AE+ L +D +V+ D GDF + A ++ P W+D GP G LG GPGYA+AA Sbjct 364 PLRVCAEIGKRLGKDDIVIGDGGDFVATAANVLKLEWPQLWMDPGPLGTLGVGPGYAMAA 423 Query 425 KLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSV 484 KLARP+ VVL+ GDG+FGF +E++ +VR + VVSVIGN+ W + LYG Sbjct 424 KLARPEANVVLVYGDGSFGFHALEFEAMVRQGIPVVSVIGNDAAWTQIRRGQVELYGEGR 483 Query 485 V-AELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNV 532 A TRYD VV ALGG G V EL PAL+ AF G PA VNV Sbjct 484 APATSLDFTRYDRVVEALGGFGACVERVEELGPALDEAFRCGRPACVNV 532 >gi|29828361|ref|NP_822995.1| TPP-requiring enzyme (acetolactate synthase II) [Streptomyces avermitilis MA-4680] gi|29605464|dbj|BAC69530.1| putative TPP-requiring enzyme [Streptomyces avermitilis MA-4680] Length=564 Score = 347 bits (891), Expect = 3e-93, Method: Compositional matrix adjust. Identities = 196/550 (36%), Positives = 301/550 (55%), Gaps = 18/550 (3%) Query 11 MHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV 70 + G L+A+ LKA G++ ++TL GGH+ IYDGC +EGI+++D RHEQ AA AA+G++++ Sbjct 13 ISGGHLVAKALKAEGVEVIYTLCGGHIIDIYDGCVDEGIKVVDVRHEQVAAHAADGYARI 72 Query 71 TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAP 130 T PG A +TAGPG T+ ++ +A A + +SP++++GG+ + MGSLQ++ HV + P Sbjct 73 TGKPGCAVVTAGPGTTDAVTGVANAFRAESPMLLIGGQGAHTQHKMGSLQDLPHVDMMTP 132 Query 131 VARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFS-MSSDNGRPGALTELP 189 + +FAAT A +V A + G +F++ P D + + R A + Sbjct 133 ITKFAATVPDTARAADMVSMAFRECYHGAPGPSFLEIPRDVLDARVPVSKARIPAAGQYR 192 Query 190 AGPTPAGD--ALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMAR 247 A AGD A+++ A LL A++P I+ G+ VW A + LV +IP MNG R Sbjct 193 ASTRSAGDPEAVEQLADLLVHAEKPAILLGSQVWTTRGTEAAVDLVRTLNIPAYMNGAGR 252 Query 248 GVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREH 307 G +P + +R A ADV ++VG P DFR+G+G ++ D Sbjct 253 GTLPPGDPHHYQLSRRYAFSNADVIVVVGTPFDFRMGYGKRLSPDATVVQIDLDYRTVGK 312 Query 308 PRPVAAGLYGD-------LTATLSALAGSGGTDHQGWIEELATAETMARDLEKAELVDDR 360 R + G+ GD +T S G + + W++EL AE A D L D Sbjct 313 NRDIDLGIVGDAGLILKSVTEAASGRLNGGASKRKEWLDELRAAEQTALDKRLPSLRSDA 372 Query 361 IPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY 420 P+HP R+ +E+ L D++ + D GD +++G+++ PG W+D GP G LG G + Sbjct 373 SPIHPYRLVSEINDFLTEDSVYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGTLGVGIPF 432 Query 421 ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALY 480 LAAK ARP ++VV L GDGAF +G +++TLVR+++ V ++GNN ++ Y Sbjct 433 VLAAKQARPDKEVVALFGDGAFSLTGWDFETLVRYDLPFVGIVGNNSSMNQIRYGQAQKY 492 Query 481 GYSVVAELRPGT-----RYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTD 535 G +A R G YD+ + LGG+GE V PA++ PAL RA SG P+++NV D Sbjct 493 G---LARERVGNTLGDVHYDKFAQMLGGYGEEVRDPADIGPALRRARESGKPSLINVWVD 549 Query 536 PSVAYPRRSN 545 P P N Sbjct 550 PDAYAPGTMN 559 >gi|313902460|ref|ZP_07835862.1| thiamine pyrophosphate TPP-binding domain-containing protein [Thermaerobacter subterraneus DSM 13965] gi|313467258|gb|EFR62770.1| thiamine pyrophosphate TPP-binding domain-containing protein [Thermaerobacter subterraneus DSM 13965] Length=547 Score = 343 bits (881), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 216/536 (41%), Positives = 304/536 (57%), Gaps = 20/536 (3%) Query 11 MHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV 70 +HAGR+IA+ L G+ +FTL GGH+ IYDGC +EGIR++D RHEQ A +AA+ ++++ Sbjct 4 VHAGRVIAQALAREGVRALFTLCGGHIMPIYDGCLDEGIRVVDVRHEQAAVYAADAYARI 63 Query 71 TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAP 130 TR PGVAA+TAGPG+ N ++A+A A + QSP+V+LGG+ P G GSLQE+DH+ V P Sbjct 64 TRRPGVAAVTAGPGVMNAVTAIANAHRAQSPVVILGGQGPLEHAGRGSLQEMDHLGVVRP 123 Query 131 VARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPA 190 + ++A Q + +++ A + ++ G +V+ P+D F+ G PA Sbjct 124 ITKWAVQVQDPKRLPEILNLAFRRSLHGVPGPVYVEIPLDVVFAQVDLEG-----VRFPA 178 Query 191 GPTPAGDAL-------DRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMN 243 P P AL +RAA +L A+RPV + G+ V W A+ R E +PV N Sbjct 179 -PVPGRSALPADPREVERAAAVLRRARRPVALVGSQVHWSPDPQAVSRFAEAAQVPVFTN 237 Query 244 GMARGVVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEP 303 GMARGV+ A F R +AL EADV L+ G P+DFRL +G +++ D Sbjct 238 GMARGVLAAGDPFFFQLCRKQALAEADVVLVAGTPLDFRLDYGQAIRREARIVQIDLDPG 297 Query 304 AREHPRPVAAGLYGDLTATLSALAGSG-----GTDHQGWIEELATAETMARDLEKAELVD 358 R V AGL GD L L +G + + W++ L E +A L Sbjct 298 ELGRNRDVEAGLAGDTATVLDQLLEAGLRPDEPAERRQWLDRLREEEGRRAARMQAGLTS 357 Query 359 DRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMID-SYLPGCWLDSGPFGCLGSG 417 +P+ P+R+ AE+ A L A V+ D GDF A +++ P WLD GP G LG G Sbjct 358 HAVPVDPLRLCAEIDAALPPGATVIGDGGDFIGTAAKIVRPRRYPAGWLDPGPLGTLGVG 417 Query 418 PGYALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPME 477 G+ALAA++ RP VV+L GDGA G +E++ VR ++ V+V+GN+ W + Sbjct 418 MGFALAARVLRPDDPVVVLLGDGAAGLDLLEYEAAVRLDLPFVAVVGNDAAWTQIRRLQV 477 Query 478 ALYGYS-VVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNV 532 L+G VA RYD+VV ALGGHGE V P E+RPA+ERA ASG PA+VNV Sbjct 478 QLFGTDRAVATQLSYARYDQVVAALGGHGEWVERPEEVRPAIERALASGRPALVNV 533 >gi|317122179|ref|YP_004102182.1| thiamine pyrophosphate TPP-binding domain-containing protein [Thermaerobacter marianensis DSM 12885] gi|315592159|gb|ADU51455.1| thiamine pyrophosphate TPP-binding domain-containing protein [Thermaerobacter marianensis DSM 12885] Length=559 Score = 342 bits (877), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 218/532 (41%), Positives = 305/532 (58%), Gaps = 12/532 (2%) Query 11 MHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV 70 +HAGR++AR L G+ +FTL GGH+ IYDGC +EGIR++D RHEQ A +AA+ ++++ Sbjct 16 VHAGRVVARALAREGVRALFTLCGGHIMPIYDGCLDEGIRVVDVRHEQAAVYAADAYARI 75 Query 71 TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAP 130 TR PGVAA+TAGPG+ N ++A+A A + QSP+V+LGG+ P G GSLQE+DH+ V Sbjct 76 TRRPGVAAVTAGPGVMNAVTAIANAHRAQSPVVILGGQGPLEHAGRGSLQEMDHLGVVRS 135 Query 131 VARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFS-MSSDNGR-PGALTEL 188 + ++A Q A +++ A + ++ G +V+ P+D F+ + D R P + + Sbjct 136 ITKWAVQVQDARRLPEILNLAFRRSLHGVPGPVYVEIPLDVVFAQVQLDAVRFPAPVPDR 195 Query 189 PAGPTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARG 248 PA P + ++RAA LL A+RPV + G+ + W A+ R E +PV NGMARG Sbjct 196 PAHPADPAE-VERAAALLRRARRPVALVGSQIHWSPDPQAVARFAEAARVPVFTNGMARG 254 Query 249 VVPADHRLAFSRARSKALGEADVALIVGVPMDFRLGFGGVFGSTTQLIVADRVEPAREHP 308 V+ F R AL +ADV L+ G P+DFRL +G +LI D Sbjct 255 VMGPGDPFFFQLCRKTALADADVVLVAGTPLDFRLDYGQSIHREARLIQIDLDPGELGRN 314 Query 309 RPVAAGLYGDLTATLSALAGSG-----GTDHQGWIEELATAETMARDLEKAELVDDRIPL 363 R VA GL GD L L +G D Q W+E L E +A + D +P+ Sbjct 315 RDVACGLAGDTGTVLDQLLEAGLAPDEPADRQRWLERLREEEDRRARQMQASMTSDAVPV 374 Query 364 HPMRVYAELAALLERDALVVIDAGDFGSYAGRMID-SYLPGCWLDSGPFGCLGSGPGYAL 422 P+R+ AE+ A L V+ D GDF A +++ P WLD GP G LG GPG+AL Sbjct 375 DPLRLCAEIDAALPPGTTVIGDGGDFIGTAAKIVRPRRYPAGWLDPGPLGTLGVGPGFAL 434 Query 423 AAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYG- 481 A++ RP VV+L GDGA G +E++ VR + V+V+GN+ W + L+G Sbjct 435 GARVLRPDDPVVVLLGDGAAGLDLLEFEAAVRQGLPFVAVVGNDAAWTQIRRLQVQLFGA 494 Query 482 -YSVVAELRPGTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNV 532 +V EL RYD VV ALGGHGE V P ++RPALERA ASG PA+VNV Sbjct 495 DRAVATELS-HARYDRVVEALGGHGEWVERPGDVRPALERALASGKPALVNV 545 >gi|41407630|ref|NP_960466.1| hypothetical protein MAP1532 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41395983|gb|AAS03849.1| hypothetical protein MAP_1532 [Mycobacterium avium subsp. paratuberculosis K-10] gi|336457582|gb|EGO36587.1| thiamine pyrophosphate-dependent enzyme, probable carboxylase/decarboxylase/carboligase [Mycobacterium avium subsp. paratuberculosis S397] Length=212 Score = 333 bits (855), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 173/211 (82%), Positives = 190/211 (91%), Gaps = 0/211 (0%) Query 1 MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTA 60 M++D PA T+HAGRL+ARRL+A G+DTVFTLSGGHLFSIYDGCR+EGIRLIDTRHEQTA Sbjct 1 MTSDATPAPTLHAGRLVARRLRAGGVDTVFTLSGGHLFSIYDGCRDEGIRLIDTRHEQTA 60 Query 61 AFAAEGWSKVTRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ 120 FAAEGWSKVTR+PGVAALTAGPG+TNGMSAMAAAQQN SPLVVLGGRAPA RWGMGSLQ Sbjct 61 TFAAEGWSKVTRLPGVAALTAGPGVTNGMSAMAAAQQNSSPLVVLGGRAPAQRWGMGSLQ 120 Query 121 EIDHVPFVAPVARFAATAQSAENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNG 180 EIDHVPFVAP+ARFAATAQSA +AG LVD AL+AAV APSGV FVDFPMDH FSM++D+G Sbjct 121 EIDHVPFVAPLARFAATAQSAADAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMAADDG 180 Query 181 RPGALTELPAGPTPAGDALDRAAGLLSTAQR 211 RPGAL +LP P P G AL RAAGLLS A+R Sbjct 181 RPGALIDLPREPEPDGAALGRAAGLLSGAKR 211 Lambda K H 0.319 0.135 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1210654467756 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40