BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2027c Length=573 Score E Sequences producing significant alignments: (Bits) Value gi|31793209|ref|NP_855702.1| histidine kinase response regulator... 1128 0.0 gi|15609164|ref|NP_216543.1| histidine kinase response regulator... 1128 0.0 gi|340627038|ref|YP_004745490.1| putative histidine kinase respo... 1120 0.0 gi|167970443|ref|ZP_02552720.1| hypothetical histidine kinase re... 1096 0.0 gi|120402406|ref|YP_952235.1| GAF sensor signal transduction his... 727 0.0 gi|118468427|ref|YP_889487.1| GAF family protein [Mycobacterium ... 725 0.0 gi|108801089|ref|YP_641286.1| putative signal transduction histi... 702 0.0 gi|126436927|ref|YP_001072618.1| GAF sensor signal transduction ... 702 0.0 gi|108798050|ref|YP_638247.1| GAF sensor signal transduction his... 676 0.0 gi|240168621|ref|ZP_04747280.1| two component sensor histidine k... 665 0.0 gi|340628108|ref|YP_004746560.1| two component sensor histidine ... 655 0.0 gi|15610268|ref|NP_217648.1| two component sensor histidine kina... 654 0.0 gi|289448811|ref|ZP_06438555.1| two component system sensor hist... 654 0.0 gi|31794308|ref|NP_856801.1| two component sensor histidine kina... 653 0.0 gi|289763315|ref|ZP_06522693.1| two component sensor histidine k... 653 0.0 gi|333919784|ref|YP_004493365.1| GAF sensor signal transduction ... 652 0.0 gi|145224426|ref|YP_001135104.1| GAF sensor signal transduction ... 645 0.0 gi|315444759|ref|YP_004077638.1| histidine kinase with GAF domai... 644 0.0 gi|183981532|ref|YP_001849823.1| two-component sensor histidine ... 643 0.0 gi|118617913|ref|YP_906245.1| two component sensor histidine kin... 642 0.0 gi|333991619|ref|YP_004524233.1| two-component sensor histidine ... 624 2e-176 gi|111017071|ref|YP_700043.1| sensor kinase, two-component syste... 589 4e-166 gi|226359607|ref|YP_002777385.1| two-component histidine kinase ... 583 3e-164 gi|289758147|ref|ZP_06517525.1| LOW QUALITY PROTEIN: GAF sensor ... 565 9e-159 gi|339294953|gb|AEJ47064.1| hypothetical histidine kinase respon... 540 3e-151 gi|302526810|ref|ZP_07279152.1| predicted protein [Streptomyces ... 538 7e-151 gi|317507620|ref|ZP_07965333.1| GAF domain-containing protein [S... 527 2e-147 gi|326385155|ref|ZP_08206823.1| sensor kinase, two-component sys... 527 2e-147 gi|343925109|ref|ZP_08764641.1| two-component histidine kinase D... 523 4e-146 gi|169630969|ref|YP_001704618.1| histidine kinase response regul... 517 2e-144 gi|258652223|ref|YP_003201379.1| GAF sensor signal transduction ... 514 2e-143 gi|289746020|ref|ZP_06505398.1| histidine kinase response regula... 511 1e-142 gi|54024863|ref|YP_119105.1| putative two-component system senso... 511 1e-142 gi|300787342|ref|YP_003767633.1| two-component system sensor kin... 500 3e-139 gi|296394764|ref|YP_003659648.1| GAF sensor signal transduction ... 486 4e-135 gi|226306907|ref|YP_002766867.1| two-component histidine kinase ... 483 5e-134 gi|339294954|gb|AEJ47065.1| histidine kinase response regulator ... 479 7e-133 gi|240171513|ref|ZP_04750172.1| two-component sensor histidine k... 426 7e-117 gi|256376041|ref|YP_003099701.1| GAF sensor signal transduction ... 415 1e-113 gi|317507119|ref|ZP_07964880.1| GAF domain-containing protein [S... 412 8e-113 gi|183983462|ref|YP_001851753.1| two-component sensor histidine ... 409 6e-112 gi|296394120|ref|YP_003659004.1| GAF sensor signal transduction ... 407 2e-111 gi|296171252|ref|ZP_06852656.1| GAF family protein [Mycobacteriu... 407 3e-111 gi|300787438|ref|YP_003767729.1| two-component system sensor kin... 405 1e-110 gi|296169095|ref|ZP_06850754.1| GAF family protein [Mycobacteriu... 404 2e-110 gi|72163445|ref|YP_291102.1| GAF:ATP-binding protein [Thermobifi... 404 2e-110 gi|325001932|ref|ZP_08123044.1| GAF sensor signal transduction h... 394 2e-107 gi|226361382|ref|YP_002779160.1| two-component histidine kinase ... 394 2e-107 gi|340528954|gb|AEK44159.1| two-component system sensor kinase [... 394 3e-107 gi|41409368|ref|NP_962204.1| hypothetical protein MAP3270c [Myco... 390 2e-106 >gi|31793209|ref|NP_855702.1| histidine kinase response regulator [Mycobacterium bovis AF2122/97] gi|121637913|ref|YP_978136.1| histidine kinase response regulator [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990407|ref|YP_002645094.1| histidine kinase response regulator [Mycobacterium bovis BCG str. Tokyo 172] 8 more sequence titles Length=573 Score = 1128 bits (2917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 571/573 (99%), Positives = 573/573 (100%), Gaps = 0/573 (0%) Query 1 VTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 +THPDRANVNPGSPP+RETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL Sbjct 1 MTHPDRANVNPGSPPVRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 Query 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG Sbjct 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 Query 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS Sbjct 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 Query 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE Sbjct 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 Query 241 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR 300 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR Sbjct 241 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR 300 Query 301 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD 360 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD Sbjct 301 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD 360 Query 361 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE 420 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE Sbjct 361 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE 420 Query 421 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS 480 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS Sbjct 421 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS 480 Query 481 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL 540 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL Sbjct 481 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL 540 Query 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR 573 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR Sbjct 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR 573 >gi|15609164|ref|NP_216543.1| histidine kinase response regulator [Mycobacterium tuberculosis H37Rv] gi|15841514|ref|NP_336551.1| GAF family protein [Mycobacterium tuberculosis CDC1551] gi|148661841|ref|YP_001283364.1| histidine kinase response regulator [Mycobacterium tuberculosis H37Ra] 53 more sequence titles Length=573 Score = 1128 bits (2917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 572/573 (99%), Positives = 573/573 (100%), Gaps = 0/573 (0%) Query 1 VTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 +THPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL Sbjct 1 MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 Query 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG Sbjct 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 Query 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS Sbjct 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 Query 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE Sbjct 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 Query 241 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR 300 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR Sbjct 241 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR 300 Query 301 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD 360 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD Sbjct 301 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD 360 Query 361 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE 420 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE Sbjct 361 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE 420 Query 421 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS 480 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS Sbjct 421 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS 480 Query 481 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL 540 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL Sbjct 481 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL 540 Query 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR 573 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR Sbjct 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR 573 >gi|340627038|ref|YP_004745490.1| putative histidine kinase response regulator [Mycobacterium canettii CIPT 140010059] gi|340005228|emb|CCC44382.1| putative histidine kinase response regulator [Mycobacterium canettii CIPT 140010059] Length=573 Score = 1120 bits (2897), Expect = 0.0, Method: Compositional matrix adjust. Identities = 568/573 (99%), Positives = 570/573 (99%), Gaps = 0/573 (0%) Query 1 VTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 +THPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL Sbjct 1 MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 Query 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG Sbjct 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 Query 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 ALIEEPKPIRLDDI+RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS Sbjct 121 ALIEEPKPIRLDDIARHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 Query 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE Sbjct 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 Query 241 ALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR 300 ALTLMA AATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR Sbjct 241 ALTLMAAAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDR 300 Query 301 TPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFAD 360 TPRRFDRLDL VDGPVEPGPALVLPLRAADTVAGVLVALR ADEQPFSDKQLDMMAAFAD Sbjct 301 TPRRFDRLDLTVDGPVEPGPALVLPLRAADTVAGVLVALRRADEQPFSDKQLDMMAAFAD 360 Query 361 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE 420 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE Sbjct 361 QAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRE 420 Query 421 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS 480 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS Sbjct 421 SIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLS 480 Query 481 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL 540 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL Sbjct 481 VVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGL 540 Query 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR 573 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR Sbjct 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPLR 573 >gi|167970443|ref|ZP_02552720.1| hypothetical histidine kinase response regulator [Mycobacterium tuberculosis H37Ra] gi|254551052|ref|ZP_05141499.1| histidine kinase response regulator [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|297634604|ref|ZP_06952384.1| histidine kinase response regulator [Mycobacterium tuberculosis KZN 4207] gi|297731592|ref|ZP_06960710.1| histidine kinase response regulator [Mycobacterium tuberculosis KZN R506] gi|313658925|ref|ZP_07815805.1| histidine kinase response regulator [Mycobacterium tuberculosis KZN V2475] Length=558 Score = 1096 bits (2835), Expect = 0.0, Method: Compositional matrix adjust. Identities = 557/558 (99%), Positives = 558/558 (100%), Gaps = 0/558 (0%) Query 16 LRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE 75 +RETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE Sbjct 1 MRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE 60 Query 76 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS 135 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS Sbjct 61 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS 120 Query 136 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG 195 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG Sbjct 121 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG 180 Query 196 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP 255 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP Sbjct 181 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP 240 Query 256 LDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGP 315 LDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGP Sbjct 241 LDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGP 300 Query 316 VEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQM 375 VEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQM Sbjct 301 VEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQM 360 Query 376 REVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQE 435 REVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQE Sbjct 361 REVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQE 420 Query 436 IRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLR 495 IRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLR Sbjct 421 IRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLR 480 Query 496 EAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFT 555 EAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFT Sbjct 481 EAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFT 540 Query 556 VENMPTGGTLLRWSAPLR 573 VENMPTGGTLLRWSAPLR Sbjct 541 VENMPTGGTLLRWSAPLR 558 >gi|120402406|ref|YP_952235.1| GAF sensor signal transduction histidine kinase [Mycobacterium vanbaalenii PYR-1] gi|119955224|gb|ABM12229.1| GAF sensor signal transduction histidine kinase [Mycobacterium vanbaalenii PYR-1] Length=559 Score = 727 bits (1877), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/559 (68%), Positives = 456/559 (82%), Gaps = 2/559 (0%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR+TLSQLRLRELL EVQDR+EQIVEGRDRLDGL+DA+L +TSGL+LD TLR IV TA Sbjct 3 PLRDTLSQLRLRELLNEVQDRVEQIVEGRDRLDGLLDAMLVVTSGLELDETLRTIVRTAI 62 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 +LVDA+YGALGVRG+DH LVEF+Y+GIDE+++ LIG LPEGRGVLG LI++PKPIRLD I Sbjct 63 DLVDAQYGALGVRGHDHELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRI 122 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 S+HPASVGFP +HPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS+DDEVLVQALAAAA Sbjct 123 SQHPASVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQALAAAA 182 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIA++NARL+++S+TR +WIEATRDIGT+ML+GADP+ VFRL+A+++ L +TLVAV Sbjct 183 GIAIENARLYQQSKTRRSWIEATRDIGTEMLSGADPSKVFRLVADQSRLLSGAQSTLVAV 242 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDG 314 D + VD+LV+V AG+ P V + G++IG VF +TP RFD L+L Sbjct 243 RSDLDELDGRVDELVVVATAGD-GPGVSLSAIPTHGSAIGEVFSTKTPVRFDTLELEPRH 301 Query 315 PVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQ 374 + PGPALVLPLRA DTVAGVLVALR PF+ ++LDMMAAF DQAALAW+LAT QRQ Sbjct 302 -LAPGPALVLPLRATDTVAGVLVALRPEGAPPFNAEELDMMAAFVDQAALAWQLATTQRQ 360 Query 375 MREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQ 434 +RE+++LTDRDRIARDLHDHVIQRLFAVGL LQG PRAR P VRE + +DDLQ++IQ Sbjct 361 LRELDVLTDRDRIARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQVIQ 420 Query 435 EIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVL 494 EIR+AIFDLH G + LR RLD+ I Q +HTTVQ++GPLSVVD L++HAEAV+ Sbjct 421 EIRTAIFDLHGGHGGSNRLRQRLDEAIAQFTASDVHTTVQFSGPLSVVDPALSDHAEAVV 480 Query 495 REAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEF 554 REAVSNA+RH+ AT+L ++V+ D++ +EV DDG G+ D+TESGL NLRQRA D GG F Sbjct 481 REAVSNAIRHSGATTLDVSVTAADELIIEVADDGCGMPADVTESGLTNLRQRAGDVGGTF 540 Query 555 TVENMPTGGTLLRWSAPLR 573 TVE+ GGT LRW APLR Sbjct 541 TVESGDAGGTRLRWCAPLR 559 >gi|118468427|ref|YP_889487.1| GAF family protein [Mycobacterium smegmatis str. MC2 155] gi|118169714|gb|ABK70610.1| GAF family protein [Mycobacterium smegmatis str. MC2 155] Length=571 Score = 725 bits (1872), Expect = 0.0, Method: Compositional matrix adjust. Identities = 382/558 (69%), Positives = 442/558 (80%), Gaps = 6/558 (1%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR+TLSQLRLRELL EVQDR+EQIVEGRDRLDGL++A+L +TSGL+LD TLR IVHTA Sbjct 18 PLRDTLSQLRLRELLSEVQDRVEQIVEGRDRLDGLVEAMLVVTSGLELDVTLRTIVHTAI 77 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 ELVDARYGALGVRG DH L+EF+YEGI E R IG LPEGRGVLG LI++PKPIRLDDI Sbjct 78 ELVDARYGALGVRGEDHHLIEFIYEGITPEVREEIGPLPEGRGVLGVLIDDPKPIRLDDI 137 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 HPASVGFP +HPPMRTFLGVPVR RD+VFGNLYLTEK +GQPFS+DDEVLVQALAAAA Sbjct 138 RLHPASVGFPPNHPPMRTFLGVPVRTRDKVFGNLYLTEKTNGQPFSEDDEVLVQALAAAA 197 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAVDNARL+EES+ R+AWI ATRDIGTQ+L+G DPA VFRL+A EALTL TLVAV Sbjct 198 GIAVDNARLYEESQARQAWIAATRDIGTQLLSGTDPATVFRLVAAEALTLTGADGTLVAV 257 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDG 314 P D +A A E +LVIVEVAG + V+ + V +IG F DR PRR D L DG Sbjct 258 PADPDASAAE--ELVIVEVAGAVPAEVEASAIPVQDNAIGQAFRDRAPRRLDVL----DG 311 Query 315 PVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQ 374 P GPALVLPLRA DTVAGVLVA++ + +PF+ +QL+MM FADQAA+AW+LA++QR+ Sbjct 312 PGLGGPALVLPLRATDTVAGVLVAVQGSGARPFTAEQLEMMTGFADQAAVAWQLASSQRR 371 Query 375 MREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQ 434 M E++IL DRDRIARDLHDHVIQRLFAVGL+LQG PRAR V++ I +DDLQ +I Sbjct 372 MSELDILADRDRIARDLHDHVIQRLFAVGLSLQGTIPRARSAEVQQRIADCVDDLQAVIS 431 Query 435 EIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVL 494 EIR+AIFDLH T LR RLD+ I Q + LHTT Q+ GPLSVVD LA+HAEAVL Sbjct 432 EIRTAIFDLHHTAPGGTRLRQRLDEAIAQFSGAGLHTTSQFVGPLSVVDAELADHAEAVL 491 Query 495 REAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEF 554 REAVSN VRH+ A L + V VEDD+ +EV DDG GISG +TESGL NLRQRAD GGE Sbjct 492 REAVSNVVRHSGANELTVRVKVEDDLSIEVTDDGEGISGPVTESGLSNLRQRADQCGGEL 551 Query 555 TVENMPTGGTLLRWSAPL 572 + + P GGT+LRW+APL Sbjct 552 RIIDRPGGGTILRWTAPL 569 >gi|108801089|ref|YP_641286.1| putative signal transduction histidine kinase [Mycobacterium sp. MCS] gi|119870230|ref|YP_940182.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. KMS] gi|108771508|gb|ABG10230.1| putative signal transduction histidine kinase [Mycobacterium sp. MCS] gi|119696319|gb|ABL93392.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. KMS] Length=568 Score = 702 bits (1813), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/561 (68%), Positives = 443/561 (79%), Gaps = 5/561 (0%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 G PLR+TLS LRLRELL EVQDRIE IVEGRDRLDGL+DA+L +T+GL+LD TLR IVH Sbjct 12 GPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGLELDVTLRTIVH 71 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 TA +LVDARYGALGVRG+ H LV+F+YEGID+ TR LIG LPEGRGVLG LI++P+PIRL Sbjct 72 TAIQLVDARYGALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLGVLIDDPRPIRL 131 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 DDI H ASVGFP +HPPMRTFLGVPVRIRDEV+GNLYLT+K GQPF+++DEVLVQALA Sbjct 132 DDIRHHSASVGFPANHPPMRTFLGVPVRIRDEVYGNLYLTDKVGGQPFTEEDEVLVQALA 191 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 AAAGIA+DNARL+E++R R+AWI ATRDI T+ML+GA PA VFR + ++ALTL TL Sbjct 192 AAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQALTLTGADGTL 251 Query 252 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLA 311 VAVP D EAP +V DLV+VE AG + A +TVA+ + IG F RTP R DRL L Sbjct 252 VAVPGDTEAPPDQVHDLVVVESAGMFTGAA--VTVALDESPIGLAFRKRTPVRVDRLTL- 308 Query 312 VDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATA 371 G E G ALVLPLRAADTVAGVLVA R Q F+ +QLD+ AAFADQ ALAW+LA++ Sbjct 309 --GSAECGAALVLPLRAADTVAGVLVAARVPGAQEFTAEQLDVTAAFADQMALAWQLASS 366 Query 372 QRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQE 431 QR+M+E+EILTDRDRIARDLHDHVIQRLFAVGL+LQG R R V++ + ++DDLQ Sbjct 367 QRRMQELEILTDRDRIARDLHDHVIQRLFAVGLSLQGTLARVRDADVQQRLAGNVDDLQA 426 Query 432 IIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAE 491 +IQEIR+ IFDLH G S AT LR RLD+ I Q A LHTT Q+ GPLSVVD LA+HAE Sbjct 427 VIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGAGLHTTAQFVGPLSVVDATLADHAE 486 Query 492 AVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAG 551 AV+REAVSNAVRHA AT L + V+V DD+ +EV D+G GI G ITESGL NLR RA+DAG Sbjct 487 AVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRARAEDAG 546 Query 552 GEFTVENMPTGGTLLRWSAPL 572 G T+ GGTLLRW APL Sbjct 547 GTLTLGESAGGGTLLRWCAPL 567 >gi|126436927|ref|YP_001072618.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. JLS] gi|126236727|gb|ABO00128.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. JLS] Length=568 Score = 702 bits (1811), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/561 (68%), Positives = 443/561 (79%), Gaps = 5/561 (0%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 G PLR+TLS LRLRELL EVQDRIE IVEGRDRLDGL+DA+L +T+GL+LD TLR IVH Sbjct 12 GPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGLELDVTLRTIVH 71 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 TA +LVDARYGALGVRG+ H LV+F+YEGID+ TR LIG LPEGRGVLG LI++P+PIRL Sbjct 72 TAIQLVDARYGALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLGVLIDDPRPIRL 131 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 DDI H ASVGFP +HPPMRTFLGVPVRIRDEV+GNLYLT+K GQPF+++DEVLVQALA Sbjct 132 DDIRHHSASVGFPANHPPMRTFLGVPVRIRDEVYGNLYLTDKVGGQPFTEEDEVLVQALA 191 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 AAAGIA+DNARL+E++R R+AWI ATRDI T+ML+GA PA VFR + ++ALTL TL Sbjct 192 AAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQALTLTGADGTL 251 Query 252 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLA 311 VAVP D EAP +V DLV+VE AG + A +TVA+ + IG F RTP R DRL L Sbjct 252 VAVPGDTEAPPDQVHDLVVVESAGMFTGAA--VTVALDESPIGLAFRKRTPVRVDRLTL- 308 Query 312 VDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATA 371 G E G ALVLPLRAADTVAGVLVA R Q F+ +QLD+ AAFADQ ALAW+LA++ Sbjct 309 --GSAECGAALVLPLRAADTVAGVLVAARVPGAQGFTAEQLDVTAAFADQMALAWQLASS 366 Query 372 QRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQE 431 QR+M+E+EILTDRDRIARDLHDHVIQRLFAVGL+LQG R R V++ + ++DDLQ Sbjct 367 QRRMQELEILTDRDRIARDLHDHVIQRLFAVGLSLQGTLARVRDADVQQRLAGNVDDLQA 426 Query 432 IIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAE 491 +IQEIR+ IFDLH G S AT LR RLD+ I Q A LHTT Q+ GPLSVVD LA+HAE Sbjct 427 VIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGARLHTTAQFVGPLSVVDATLADHAE 486 Query 492 AVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAG 551 AV+REAVSNAVRHA AT L + V+V DD+ +EV D+G GI G ITESGL NLR RA+DAG Sbjct 487 AVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRARAEDAG 546 Query 552 GEFTVENMPTGGTLLRWSAPL 572 G T+ GGTLLRW APL Sbjct 547 GTLTLGESAGGGTLLRWCAPL 567 >gi|108798050|ref|YP_638247.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. MCS] gi|119867145|ref|YP_937097.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. KMS] gi|126433710|ref|YP_001069401.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. JLS] gi|108768469|gb|ABG07191.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. MCS] gi|119693234|gb|ABL90307.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. KMS] gi|126233510|gb|ABN96910.1| GAF sensor signal transduction histidine kinase [Mycobacterium sp. JLS] Length=566 Score = 676 bits (1745), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/571 (64%), Positives = 439/571 (77%), Gaps = 14/571 (2%) Query 8 NVNPGSP----PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLD 63 V PG P+ ETLSQLRLRELL EVQDR+E+IVEGRDRLDGL+DA+L +TSGL LD Sbjct 3 GVGPGDQCSVRPIGETLSQLRLRELLTEVQDRVEEIVEGRDRLDGLVDAMLTVTSGLDLD 62 Query 64 ATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALI 123 ATLR IVHTA EL+DARYGALGVRG+DH LVEF+YEGIDE TR IG LP+GRGVLG LI Sbjct 63 ATLRTIVHTAIELIDARYGALGVRGHDHELVEFIYEGIDEPTRLAIGPLPQGRGVLGVLI 122 Query 124 EEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDD 183 ++P+PIRL++I HPASVGFP HHPPMRTFLGVP+RIRDEVFGNLYL+EK GQPFS+DD Sbjct 123 DDPQPIRLENIHDHPASVGFPEHHPPMRTFLGVPIRIRDEVFGNLYLSEKTSGQPFSEDD 182 Query 184 EVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALT 243 EVL QALAAAAGIA+DNARLFE+SRTR+AWIEATRDI T++L GADPA V+RL+AEE+L Sbjct 183 EVLTQALAAAAGIAIDNARLFEQSRTRQAWIEATRDIATELLGGADPARVYRLVAEESLK 242 Query 244 LMAGAATLVAVPLDDEAPACEVDDLVIVEVAGE--ISPAVKQMTVAVSGTSIGGVFHDRT 301 L VAVP D D+LVI + AG+ P+V + + + G IG F RT Sbjct 243 LTHADVAFVAVPADG-------DELVIADAAGDTRTDPSVASL-IPLQGNDIGEAFVART 294 Query 302 PRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQ 361 PR + + + GPAL+LP+R + VAGV+V LR A F+ +QL+MMAAF DQ Sbjct 295 PRLVEVIAAQTGLLDDAGPALILPMRTTEAVAGVVVLLRRAGRPAFTAEQLEMMAAFVDQ 354 Query 362 AALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRES 421 AALAW+ A AQR++RE+++LTDRDRIARDLHD VIQRLF VGLTLQG PRAR P V+ Sbjct 355 AALAWQSAVAQRRIRELDVLTDRDRIARDLHDQVIQRLFGVGLTLQGTIPRARTPDVQRR 414 Query 422 IYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSV 481 + S+DDLQE+IQ+IR+AIFDL G S +T LR RLD+ I LA L TTVQY GPLSV Sbjct 415 LIESVDDLQEVIQQIRTAIFDLQGGSSGSTRLRQRLDEAIAHLAGAELRTTVQYVGPLSV 474 Query 482 VDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLR 541 V LA+HAEAV+ EAVSNAVRHA AT L++ V+V+DD+R+E+ D+GVGI ++TESGL Sbjct 475 VGAELADHAEAVVSEAVSNAVRHAQATELSVLVTVDDDLRIEIRDNGVGIPDNLTESGLA 534 Query 542 NLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 NLR+RA++ GG T+E GGT L W+APL Sbjct 535 NLRRRAEEVGGALTIEPAAGGGTCLSWTAPL 565 >gi|240168621|ref|ZP_04747280.1| two component sensor histidine kinase DevS [Mycobacterium kansasii ATCC 12478] Length=577 Score = 665 bits (1716), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/565 (62%), Positives = 440/565 (78%), Gaps = 2/565 (0%) Query 8 NVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLR 67 ++ G PLR+TLSQLRLRELL+EVQ+R+EQIV+GRDRLDGL++A+L +TSGL LD TLR Sbjct 13 TLDSGLRPLRQTLSQLRLRELLVEVQERVEQIVDGRDRLDGLVEAMLVVTSGLDLDVTLR 72 Query 68 AIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPK 127 IVH+A LVDARYGAL V D R+++FVYEG DEET IG LP+G G++G LI+EPK Sbjct 73 TIVHSATNLVDARYGALEVHDRDKRVLQFVYEGFDEETVQAIGHLPQGLGIIGLLIDEPK 132 Query 128 PIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLV 187 P+RLDD+S HPASVGFP +HPPMRTFLGVPVR+ D G LYLT+K +GQPFSDDDE+LV Sbjct 133 PLRLDDLSLHPASVGFPANHPPMRTFLGVPVRVHDMSLGTLYLTDKTNGQPFSDDDELLV 192 Query 188 QALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAG 247 QALAAAAGIA+ NARL++++ TR++WIEATRDI T++L+GA+PA VFRL+AEEAL L A Sbjct 193 QALAAAAGIAIANARLYQQATTRQSWIEATRDIATELLSGAEPATVFRLVAEEALKLTAA 252 Query 248 AATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDR 307 A LVA+PLD+ PA EV +++++E G V ++++ T + V D +P++ ++ Sbjct 253 DAALVAIPLDENVPAAEVTEVLVIETVGSAVAPVMGQVISLTDTVLADVCADSSPKQVEK 312 Query 308 LDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWR 367 +L DG GPAL+LPLRA DT AGV+V LR P ++ QL+MMAAF+DQAALA + Sbjct 313 FEL--DGVDVAGPALLLPLRATDTCAGVVVLLRHDSSGPATEDQLEMMAAFSDQAALALQ 370 Query 368 LATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSID 427 LA +QR+MRE++++T+RDRIARDLHDHVIQRLFAVGL LQ A PRARVP V++ + +ID Sbjct 371 LAGSQRRMRELDVVTERDRIARDLHDHVIQRLFAVGLALQAAVPRARVPEVQQRLSEAID 430 Query 428 DLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLA 487 DLQ +IQEIR+ IFDLH G T LR R+D + Q A L T+VQ+ GPLSVVD +LA Sbjct 431 DLQGVIQEIRTTIFDLHGGSQGITRLRQRIDAAVAQFAGSGLRTSVQFVGPLSVVDNLLA 490 Query 488 NHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRA 547 +HAEA++REAVSNAVRHA AT+L + V V DD+ +EV D+G G+ T SGL NLR+RA Sbjct 491 DHAEAMVREAVSNAVRHARATTLMVRVKVADDLCIEVSDNGCGMPDQFTASGLTNLRRRA 550 Query 548 DDAGGEFTVENMPTGGTLLRWSAPL 572 ++AGGEF +E +GGTLLRWSAPL Sbjct 551 EEAGGEFAIEATASGGTLLRWSAPL 575 >gi|340628108|ref|YP_004746560.1| two component sensor histidine kinase DEVS [Mycobacterium canettii CIPT 140010059] gi|340006298|emb|CCC45477.1| two component sensor histidine kinase DEVS [Mycobacterium canettii CIPT 140010059] Length=578 Score = 655 bits (1690), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/560 (63%), Positives = 442/560 (79%), Gaps = 2/560 (0%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR TLSQLRL ELL+EVQDR+EQIVEGRDRLDGL++A+L +T+GL L+ATLRAIVH+AA Sbjct 17 PLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSAA 76 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 LVDARYGA+ V HR++ FVYEGIDEET IG LP+G GV+G LIE+PKP+RLDD+ Sbjct 77 SLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDV 136 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 S HPAS+GFP +HPPMRTFLGVPVR+RDE FG LYLT+K +GQPFSDDDEVLVQALAAAA Sbjct 137 SAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAA 196 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAV NARL+++++ R++WIEATRDI T++L+G +PA VFRL+A EAL L A A LVAV Sbjct 197 GIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAV 256 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDL-AVD 313 P+D++ PA +V +L+++E G + T+ V+G + VF + PRR DR+DL +D Sbjct 257 PVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD 316 Query 314 GPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQR 373 + GPAL+LPLRA TVAGV+V L F+D+QL+MMAAFADQAALAW+LAT+QR Sbjct 317 ELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQR 376 Query 374 QMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEII 433 +MRE+++LTDRDRIARDLHDHVIQRLFA+GL LQGA P R P V++ + +DDLQ++I Sbjct 377 RMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI 436 Query 434 QEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAV 493 QEIR+ I+DLH T LR R+D + Q A L T+VQ+ GPLSVVD+ LA+ AEAV Sbjct 437 QEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAV 496 Query 494 LREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGE 553 +REAVSNAVRHA A++L + V V+DD+ +EV D+G G+ + T SGL NLRQRA+ AGGE Sbjct 497 VREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGE 556 Query 554 FTVENMP-TGGTLLRWSAPL 572 FT+ ++P GT+LRWSAPL Sbjct 557 FTLASVPGASGTVLRWSAPL 576 >gi|15610268|ref|NP_217648.1| two component sensor histidine kinase DEVS [Mycobacterium tuberculosis H37Rv] gi|15842705|ref|NP_337742.1| GAF family protein [Mycobacterium tuberculosis CDC1551] gi|148662986|ref|YP_001284509.1| two component sensor histidine kinase DevS [Mycobacterium tuberculosis H37Ra] 56 more sequence titles Length=578 Score = 654 bits (1688), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/560 (63%), Positives = 442/560 (79%), Gaps = 2/560 (0%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR TLSQLRL ELL+EVQDR+EQIVEGRDRLDGL++A+L +T+GL L+ATLRAIVH+A Sbjct 17 PLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSAT 76 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 LVDARYGA+ V HR++ FVYEGIDEET IG LP+G GV+G LIE+PKP+RLDD+ Sbjct 77 SLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDV 136 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 S HPAS+GFP +HPPMRTFLGVPVR+RDE FG LYLT+K +GQPFSDDDEVLVQALAAAA Sbjct 137 SAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAA 196 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAV NARL+++++ R++WIEATRDI T++L+G +PA VFRL+A EAL L A A LVAV Sbjct 197 GIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAV 256 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDL-AVD 313 P+D++ PA +V +L+++E G ++ T+ V+G + VF + PRR DR+DL +D Sbjct 257 PVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD 316 Query 314 GPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQR 373 + GPAL+LPLRA TVAGV+V L F+D+QL+MMAAFADQAALAW+LAT+QR Sbjct 317 ELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQR 376 Query 374 QMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEII 433 +MRE+++LTDRDRIARDLHDHVIQRLFA+GL LQGA P R P V++ + +DDLQ++I Sbjct 377 RMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI 436 Query 434 QEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAV 493 QEIR+ I+DLH T LR R+D + Q A L T+VQ+ GPLSVVD+ LA+ AEAV Sbjct 437 QEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAV 496 Query 494 LREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGE 553 +REAVSNAVRHA A++L + V V+DD+ +EV D+G G+ + T SGL NLRQRA+ AGGE Sbjct 497 VREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGE 556 Query 554 FTVENMP-TGGTLLRWSAPL 572 FT+ ++P GT+LRWSAPL Sbjct 557 FTLASVPGASGTVLRWSAPL 576 >gi|289448811|ref|ZP_06438555.1| two component system sensor histidine kinase devS [Mycobacterium tuberculosis CPHL_A] gi|289421769|gb|EFD18970.1| two component system sensor histidine kinase devS [Mycobacterium tuberculosis CPHL_A] Length=578 Score = 654 bits (1686), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/560 (63%), Positives = 441/560 (79%), Gaps = 2/560 (0%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR TLSQLRL ELL+EVQDR+EQIVEGRDRLDGL++A+L +T+GL L+ATLRAIVH+A Sbjct 17 PLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSAT 76 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 LVDARYGA+ V HR++ FVYEGIDEET IG LP+G GV+G LIE+PKP+RLDD+ Sbjct 77 SLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDV 136 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 S HPAS+GFP +HPPMRTFLGVPVR+RDE FG LYLT+K +GQPFSDDDEVLVQALAAAA Sbjct 137 SAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAA 196 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAV NARL+++++ R++WIEATRDI T++L+G +PA VFRL+A EAL L A A LVAV Sbjct 197 GIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAV 256 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDL-AVD 313 P+D++ PA +V +L+++E G + T+ V+G + VF + PRR DR+DL +D Sbjct 257 PVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD 316 Query 314 GPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQR 373 + GPAL+LPLRA TVAGV+V L F+D+QL+MMAAFADQAALAW+LAT+QR Sbjct 317 ELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQR 376 Query 374 QMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEII 433 +MRE+++LTDRDRIARDLHDHVIQRLFA+GL LQGA P R P V++ + +DDLQ++I Sbjct 377 RMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI 436 Query 434 QEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAV 493 QEIR+ I+DLH T LR R+D + Q A L T+VQ+ GPLSVVD+ LA+ AEAV Sbjct 437 QEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAV 496 Query 494 LREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGE 553 +REAVSNAVRHA A++L + V V+DD+ +EV D+G G+ + T SGL NLRQRA+ AGGE Sbjct 497 VREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGE 556 Query 554 FTVENMP-TGGTLLRWSAPL 572 FT+ ++P GT+LRWSAPL Sbjct 557 FTLASVPGASGTVLRWSAPL 576 >gi|31794308|ref|NP_856801.1| two component sensor histidine kinase DEVS [Mycobacterium bovis AF2122/97] gi|121639015|ref|YP_979239.1| two component sensor histidine kinase devS [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224991507|ref|YP_002646196.1| two component sensor histidine kinase [Mycobacterium bovis BCG str. Tokyo 172] 16 more sequence titles Length=578 Score = 653 bits (1685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/560 (63%), Positives = 441/560 (79%), Gaps = 2/560 (0%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR TLSQLRL ELL+EVQDR+EQIVEGRDRLDGL++A+L +T+GL L+ATLRAIVH+A Sbjct 17 PLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSAT 76 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 LVDARYGA+ V HR++ FVYEGIDEET IG LP+G GV+G LIE+PKP+RLDD+ Sbjct 77 SLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDV 136 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 S HPAS+GFP +HPPMRTFLGVPVR+RDE FG LYLT+K +GQPFSDDDEVLVQALAAAA Sbjct 137 SAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAA 196 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAV NARL+++++ R++WIEATRDI T++L+G +PA VFRL+A EAL L A A LVAV Sbjct 197 GIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAV 256 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDL-AVD 313 P+D++ PA +V +L+++E G + T+ V+G + VF + PRR DR+DL +D Sbjct 257 PVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD 316 Query 314 GPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQR 373 + GPAL+LPLRA TVAGV+V L F+D+QL+MMAAFADQAALAW+LAT+QR Sbjct 317 ELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQR 376 Query 374 QMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEII 433 +MRE+++LTDRDRIARDLHDHVIQRLFA+GL LQGA P R P V++ + +DDLQ++I Sbjct 377 RMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI 436 Query 434 QEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAV 493 QEIR+ I+DLH T LR R+D + Q A L T+VQ+ GPLSVVD+ LA+ AEAV Sbjct 437 QEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAV 496 Query 494 LREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGE 553 +REAVSNAVRHA A++L + V V+DD+ +EV D+G G+ + T SGL NLRQRA+ AGGE Sbjct 497 VREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGE 556 Query 554 FTVENMP-TGGTLLRWSAPL 572 FT+ ++P GT+LRWSAPL Sbjct 557 FTLASVPGASGTVLRWSAPL 576 >gi|289763315|ref|ZP_06522693.1| two component sensor histidine kinase devS [Mycobacterium tuberculosis GM 1503] gi|289710821|gb|EFD74837.1| two component sensor histidine kinase devS [Mycobacterium tuberculosis GM 1503] Length=578 Score = 653 bits (1685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/560 (63%), Positives = 441/560 (79%), Gaps = 2/560 (0%) Query 15 PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 PLR TLSQLRL ELL+EVQDR+EQIVEGRDRLDGL++A+L +T+GL L+ATLRAIVH+A Sbjct 17 PLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSAT 76 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 LVDARYGA+ V HR++ FVYEGIDEET IG LP+G GV+G LIE+PKP+RLDD+ Sbjct 77 SLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDV 136 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 S HPAS+GFP +HPPMRTFLGVPVR+RDE FG LYLT+K +GQPFSDDDEVLVQALAAAA Sbjct 137 SAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAA 196 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAV NARL+++ + R++WIEATRDI T++L+G +PA VFRL+A EAL L A A LVAV Sbjct 197 GIAVANARLYQQVKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAV 256 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDL-AVD 313 P+D++ PA +V +L+++E G ++ T+ V+G + VF + PRR DR+DL +D Sbjct 257 PVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLD 316 Query 314 GPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQR 373 + GPAL+LPLRA TVAGV+V L F+D+QL+MMAAFADQAALAW+LAT+QR Sbjct 317 ELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQR 376 Query 374 QMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEII 433 +MRE+++LTDRDRIARDLHDHVIQRLFA+GL LQGA P R P V++ + +DDLQ++I Sbjct 377 RMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVI 436 Query 434 QEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAV 493 QEIR+ I+DLH T LR R+D + Q A L T+VQ+ GPLSVVD+ LA+ AEAV Sbjct 437 QEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAV 496 Query 494 LREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGE 553 +REAVSNAVRHA A++L + V V+DD+ +EV D+G G+ + T SGL NLRQRA+ AGGE Sbjct 497 VREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGE 556 Query 554 FTVENMP-TGGTLLRWSAPL 572 FT+ ++P GT+LRWSAPL Sbjct 557 FTLASVPGASGTVLRWSAPL 576 >gi|333919784|ref|YP_004493365.1| GAF sensor signal transduction histidine kinase [Amycolicicoccus subflavus DQS3-9A1] gi|333482005|gb|AEF40565.1| GAF sensor signal transduction histidine kinase [Amycolicicoccus subflavus DQS3-9A1] Length=574 Score = 652 bits (1682), Expect = 0.0, Method: Compositional matrix adjust. Identities = 342/566 (61%), Positives = 433/566 (77%), Gaps = 6/566 (1%) Query 10 NPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAI 69 PG +R TLSQLRLRELL E Q RIE++++ +DR DGLI+A+L +TSGL +D TLR I Sbjct 11 QPGQ--VRGTLSQLRLRELLRETQQRIEEMIDSKDRTDGLIEAMLVVTSGLDIDVTLRTI 68 Query 70 VHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPI 129 VH A ELVDARYGALGVRG+DH LV+F+YEGIDE TR LIG LPEGRGVLG LI++PKPI Sbjct 69 VHKAIELVDARYGALGVRGHDHSLVQFIYEGIDEHTRELIGPLPEGRGVLGLLIDQPKPI 128 Query 130 RLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQA 189 R+DD+SRHP+SVGFP HHPPM+TFLGVPVRI +EVFGNLYLTEK DGQPF+ DDEVLV+A Sbjct 129 RMDDLSRHPSSVGFPTHHPPMKTFLGVPVRIGEEVFGNLYLTEKNDGQPFTADDEVLVEA 188 Query 190 LAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAA 249 LA+AAGIA+ N+RL+E+ +TR+AWIEATRD+ T++LAG DP +VFR + +A L G Sbjct 189 LASAAGIAIANSRLYEQGQTRQAWIEATRDVSTELLAGHDPDVVFRSVVTKANQLGDGEI 248 Query 250 TLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLD 309 + +A+P D E P EV +LVIVE + E + + + + TS G F ++ P+R +RL+ Sbjct 249 SFLALPEDPELPFNEVHELVIVETS-EKGSGLLRNRIPLGRTSFGAAFIEQNPQRCERLE 307 Query 310 LAVD--GPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWR 367 L P GPAL+LPLRA ++ +GVLV RS + PF+D+Q+ MM FAD AALA R Sbjct 308 LQFPEVSPQCSGPALLLPLRAEESNSGVLVIARSPNSPPFTDEQMGMMVGFADHAALALR 367 Query 368 LATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSID 427 LA AQ ++RE++I+ DRDRIARDLHDHVIQRLFA+GL+LQGA PR R P +R+ I + D Sbjct 368 LADAQARVRELDIIADRDRIARDLHDHVIQRLFAIGLSLQGAIPRTRTPEIRQRISDATD 427 Query 428 DLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAI-PALHTTVQYTGPLSVVDTVL 486 DLQ +IQEIR+AIFDLH G A GLR RLD+ I QL +L T+V GPLSVV+ L Sbjct 428 DLQTVIQEIRTAIFDLHGGTHGAVGLRKRLDEAISQLTRDSSLRTSVHIAGPLSVVEPEL 487 Query 487 ANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQR 546 A+HAEAVLREAVSNAVRHA+ SL IN+ V++D+++EV+DDGVG+ +SGL+N++ R Sbjct 488 ADHAEAVLREAVSNAVRHAHGKSLTINIGVDNDLKIEVIDDGVGVPAGTPQSGLKNMQSR 547 Query 547 ADDAGGEFTVENMPTGGTLLRWSAPL 572 ADD G+F+V + GGT + WSAPL Sbjct 548 ADDLDGDFSVTSTAGGGTRVVWSAPL 573 >gi|145224426|ref|YP_001135104.1| GAF sensor signal transduction histidine kinase [Mycobacterium gilvum PYR-GCK] gi|145216912|gb|ABP46316.1| GAF sensor signal transduction histidine kinase [Mycobacterium gilvum PYR-GCK] Length=575 Score = 645 bits (1665), Expect = 0.0, Method: Compositional matrix adjust. Identities = 362/561 (65%), Positives = 435/561 (78%), Gaps = 3/561 (0%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 G+ P+R TLSQLRLRELL EVQDR+EQI+ GRDRLDGL++A+LA+TSGL+LD TLR IVH Sbjct 17 GARPVRTTLSQLRLRELLTEVQDRVEQIIRGRDRLDGLVEAMLAVTSGLELDETLRTIVH 76 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 TA ELVDA+YGALGVRG+D LVEF+YEGIDE R IG LPEGRGVLG LI +PKPIRL Sbjct 77 TAIELVDAQYGALGVRGHDQELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRL 136 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 +DISRH SVGFP +HPPMRTFLGVPVRIRDEVFGNLYLTEK+DGQPFS+DDEVLVQALA Sbjct 137 EDISRHADSVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQALA 196 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 AAAGIA+DNARL+ +S+ R++WIEATRDIGT++L+G DPA VFR +A+ A L AATL Sbjct 197 AAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAGVFRRVADRAQKLSGAAATL 256 Query 252 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLA 311 VAVP D + P EV +L + AGE + A + V+GT+IG F RTP DR D+ Sbjct 257 VAVPDDPDLPVGEVAELTVAASAGE-TIAAAHDPIPVAGTAIGDAFVHRTPGMTDRADIG 315 Query 312 VDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATA 371 + V GPAL+LPLRA D V GVL+ LRS QPF +LDM+AAFADQAA AW+LA+ Sbjct 316 IGATV--GPALLLPLRAPDAVPGVLIVLRSVGAQPFRSDELDMLAAFADQAAQAWQLAST 373 Query 372 QRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQE 431 Q ++RE+ ILTDRDRIARDLHDHVIQRLFAVGL+LQG+ RAR V++ + +++DDLQ Sbjct 374 QHRLRELGILTDRDRIARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQS 433 Query 432 IIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAE 491 +IQEIR+AIFDLH G S T LR RLD + + T++Q GPLSVVD LA+HAE Sbjct 434 VIQEIRTAIFDLHGGSSAVTRLRQRLDAAVAAFPESGVRTSMQCAGPLSVVDAGLADHAE 493 Query 492 AVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAG 551 AV+REAVSNAVRHA A+++A+ V+VEDD+ + V DDG GI+ D+T SGL NL +RA D G Sbjct 494 AVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIAADVTGSGLANLARRAQDVG 553 Query 552 GEFTVENMPTGGTLLRWSAPL 572 G F+V GT L W APL Sbjct 554 GSFSVRRGAQVGTTLTWRAPL 574 >gi|315444759|ref|YP_004077638.1| histidine kinase with GAF domain [Mycobacterium sp. Spyr1] gi|315263062|gb|ADT99803.1| histidine kinase with GAF domain [Mycobacterium sp. Spyr1] Length=575 Score = 644 bits (1662), Expect = 0.0, Method: Compositional matrix adjust. Identities = 361/561 (65%), Positives = 435/561 (78%), Gaps = 3/561 (0%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 G+ P+R TLSQLRLRELL EVQDR+EQI+ GRDRLDGL++A+LA+TSGL+LD TLR IVH Sbjct 17 GARPVRTTLSQLRLRELLTEVQDRVEQIIRGRDRLDGLVEAMLAVTSGLELDETLRTIVH 76 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 TA ELVDA+YGALGVRG+D LVEF+YEGIDE R IG LPEGRGVLG LI +PKPIRL Sbjct 77 TAIELVDAQYGALGVRGHDQELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRL 136 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 +DISRH SVGFP +HPPMRTFLGVPVRIRDEVFGNLYLTEK+DGQPFS+DDEVLVQALA Sbjct 137 EDISRHADSVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQALA 196 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 AAAGIA+DNARL+ +S+ R++WIEATRDIGT++L+G DPA VFR +A+ A L AATL Sbjct 197 AAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAGVFRRVADRAQKLSGAAATL 256 Query 252 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLA 311 VAVP D + P EV +L + AGE + A + V+GT+IG F RTP DR D+ Sbjct 257 VAVPDDPDLPVGEVAELTVAASAGE-TIAAAHDPIPVAGTAIGDAFVHRTPGMTDRADIG 315 Query 312 VDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATA 371 + V GPAL+LPLRA D V GVL+ LRS QPF +LDM+AAFADQAA AW+LA+ Sbjct 316 IGATV--GPALLLPLRAPDAVPGVLIVLRSVGAQPFRSDELDMLAAFADQAAQAWQLAST 373 Query 372 QRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQE 431 Q ++RE+ ILTDRDRIARDLHDHVIQRLFAVGL+LQG+ R+R V++ + +++DDLQ Sbjct 374 QHRLRELGILTDRDRIARDLHDHVIQRLFAVGLSLQGSIARSRSEEVQQRLSANVDDLQS 433 Query 432 IIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAE 491 +IQEIR+AIFDLH G S T LR RLD + + T++Q GPLSVVD LA+HAE Sbjct 434 VIQEIRTAIFDLHGGSSAVTRLRQRLDAAVAAFPESGVRTSMQCAGPLSVVDAGLADHAE 493 Query 492 AVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAG 551 AV+REAVSNAVRHA A+++A+ V+VEDD+ + V DDG GI+ D+T SGL NL +RA D G Sbjct 494 AVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIAADVTGSGLANLARRAQDVG 553 Query 552 GEFTVENMPTGGTLLRWSAPL 572 G F+V GT L W APL Sbjct 554 GSFSVRRGAQVGTTLTWRAPL 574 >gi|183981532|ref|YP_001849823.1| two-component sensor histidine kinase DevS [Mycobacterium marinum M] gi|183174858|gb|ACC39968.1| two-component sensor histidine kinase DevS [Mycobacterium marinum M] Length=585 Score = 643 bits (1659), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/578 (62%), Positives = 445/578 (77%), Gaps = 8/578 (1%) Query 3 HPDRANVNPGSP------PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAI 56 HP A G P PLR TLSQLRLRELL+EVQ+R+EQIVEGRDRLDGL++A+L + Sbjct 6 HPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVEGRDRLDGLVEAMLVV 65 Query 57 TSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGR 116 TSGL+L+ATLR IVH+A LVDARY AL V D R+++FVYEGIDE+T IG LPEG Sbjct 66 TSGLELNATLRTIVHSATNLVDARYCALEVHDRDKRVLQFVYEGIDEDTVARIGHLPEGL 125 Query 117 GVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADG 176 GV+G LI+EPKP+RL+DIS+HPAS+GFP HHPPMRTFLGVPVR+RD G LYLT+K +G Sbjct 126 GVIGLLIDEPKPLRLEDISQHPASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNG 185 Query 177 QPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRL 236 QPFSDDDE+LVQALAAAAGIA+ NARL+E+++ R+AWI ATRDI T++L+G +PA VFRL Sbjct 186 QPFSDDDELLVQALAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRL 245 Query 237 IAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGV 296 +AEEAL L + A LVAVP+D++ PA EV L+++E G A + T+AV+GT++ V Sbjct 246 VAEEALKLTSADAALVAVPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGTALAEV 305 Query 297 FHDRTPRRFDRLDL-AVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMM 355 D PR+ D++ + VD + GPALVLPLRA D VAGV+V L + + +++QL+MM Sbjct 306 LLDSAPRQVDKIAVEGVDELGDTGPALVLPLRATDAVAGVVVLLHPSSPESVTEEQLEMM 365 Query 356 AAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARV 415 AAFADQAALA +LAT+QR+MRE++++T+RDRIARDLHDHVIQRLFA+GL LQG+ PR R Sbjct 366 AAFADQAALALQLATSQRRMRELDVMTERDRIARDLHDHVIQRLFAIGLALQGSVPRTRE 425 Query 416 PAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQY 475 P V++ + IDDLQ +IQEIR+ IFDLH T LR R+D + L TTVQ+ Sbjct 426 PKVQQRLSEVIDDLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSSGLRTTVQF 485 Query 476 TGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDI 535 GPLSVVD VLA+HAEAV+REAVSNAVRHA AT+L + V V+DD+ +EV D+G G+ Sbjct 486 IGPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMPKTY 545 Query 536 TESGLRNLRQRADDAGGEFTVEN-MPTGGTLLRWSAPL 572 T SGL NLR+RA +AGG+FT+E+ GGTLLRWSAPL Sbjct 546 TSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPL 583 >gi|118617913|ref|YP_906245.1| two component sensor histidine kinase DevS [Mycobacterium ulcerans Agy99] gi|118570023|gb|ABL04774.1| two component sensor histidine kinase DevS [Mycobacterium ulcerans Agy99] Length=585 Score = 642 bits (1657), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/578 (62%), Positives = 446/578 (78%), Gaps = 8/578 (1%) Query 3 HPDRANVNPGSP------PLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAI 56 HP A + G P PLR TLSQLRLRELL+EVQ+R+EQIVEGRDRLDGL++A+L + Sbjct 6 HPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVEGRDRLDGLVEAMLVV 65 Query 57 TSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGR 116 TSGL+LDATLR IVH+A LVDARY AL V D R+++FVYEGIDE+T IG LPEG Sbjct 66 TSGLELDATLRTIVHSATNLVDARYCALEVHDRDKRVLQFVYEGIDEDTVARIGHLPEGL 125 Query 117 GVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADG 176 G++G LI+EPKP+RL+DIS+HPAS+GFP HHPPMRTFLGVPVR+RD G LYLT+K +G Sbjct 126 GIIGLLIDEPKPLRLEDISQHPASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNG 185 Query 177 QPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRL 236 QPFSDDDE+LVQALAAAAGIA+ NARL+E+++ R+AWI ATRDI T++L+G +PA VFRL Sbjct 186 QPFSDDDELLVQALAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRL 245 Query 237 IAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGV 296 +AEEAL L + A LVA+P+D++ PA EV L+++E G A + T+AV+GT++ V Sbjct 246 VAEEALKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGTALAEV 305 Query 297 FHDRTPRRFDRLDLA-VDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMM 355 D PR+ D++ + VD + GPALVLPLRA D VAGV+V L + + +++QL+MM Sbjct 306 LLDSAPRQVDKIAVEDVDELGDMGPALVLPLRATDAVAGVVVLLHPSSPESVTEEQLEMM 365 Query 356 AAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARV 415 AAFADQAALA +LAT+QR+MRE++++T+RDRIARDLHDHVIQRLFA+GL LQG+ PR R Sbjct 366 AAFADQAALALQLATSQRRMRELDVVTERDRIARDLHDHVIQRLFAIGLALQGSVPRTRE 425 Query 416 PAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQY 475 P V++ + IDDLQ +IQEIR+ IFDLH T LR R+D + L TTVQ+ Sbjct 426 PKVQQRLSEVIDDLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSSGLRTTVQF 485 Query 476 TGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDI 535 GPLSVVD VLA+HAEAV+REAVSNAVRHA AT+L + V V+DD+ +EV D+G G+ Sbjct 486 IGPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMPKTY 545 Query 536 TESGLRNLRQRADDAGGEFTVEN-MPTGGTLLRWSAPL 572 T SGL NLR+RA +AGG+FT+E+ GGTLLRWSAPL Sbjct 546 TSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPL 583 >gi|333991619|ref|YP_004524233.1| two-component sensor histidine kinase [Mycobacterium sp. JDM601] gi|333487587|gb|AEF36979.1| two-component sensor histidine kinase DevS [Mycobacterium sp. JDM601] Length=569 Score = 624 bits (1608), Expect = 2e-176, Method: Compositional matrix adjust. Identities = 352/561 (63%), Positives = 439/561 (79%), Gaps = 2/561 (0%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 G PLR+TLSQLRLRELL+ VQDR+EQIVEGRDRLDGL+ A+L +TSGL+LDATLR+IV Sbjct 9 GPDPLRDTLSQLRLRELLVGVQDRVEQIVEGRDRLDGLLAAMLVVTSGLELDATLRSIVQ 68 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 TA LVDA+YGAL V D R++EFV+EGID++T IG LPEG GV+G LIE+PKP+RL Sbjct 69 TATNLVDAKYGALEVHDNDRRMLEFVHEGIDDDTFARIGRLPEGLGVVGLLIEDPKPLRL 128 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 DD+++HP+SVGFP HP MRTFLGVPV +RDEVFGNLYLTEKA+G PFS+DDEVLVQALA Sbjct 129 DDLTKHPSSVGFPSGHPTMRTFLGVPVGVRDEVFGNLYLTEKANGLPFSEDDEVLVQALA 188 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 AAAGIA+ NARL+ +++ R++WIE+TRDI T++L+G DP+ VFRLIAEEA L + L Sbjct 189 AAAGIAIANARLYAQAKARQSWIESTRDIATELLSGTDPSTVFRLIAEEAGKLTGSESAL 248 Query 252 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLA 311 VA+PLDD+ EV++L++VE G + + T+ V+G+S+G F R PR+ R LA Sbjct 249 VAIPLDDDTLEAEVNELLVVETIGAVMAPLDGDTIPVAGSSVGEAFSQRKPRQVAR--LA 306 Query 312 VDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATA 371 + G GPAL+LPLRAAD VAGV+V +R PFS +QLDMMAAFADQAALAW+LAT+ Sbjct 307 LPGIDATGPALILPLRAADAVAGVVVVMRHGTTIPFSVEQLDMMAAFADQAALAWQLATS 366 Query 372 QRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQE 431 QR+M E+++LTDRDRIARDLHDHVIQRLFAVGL+LQG PRAR VR + ++DD+QE Sbjct 367 QRRMHELDVLTDRDRIARDLHDHVIQRLFAVGLSLQGTIPRARDAVVRRRLTDAVDDMQE 426 Query 432 IIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAE 491 II EIR+ IFDLH + T LR RLD + Q + LHTTV + GPLSVV+ VLA+HAE Sbjct 427 IIGEIRTTIFDLHGTSATVTRLRQRLDNAVAQFSGSGLHTTVAFIGPLSVVEPVLADHAE 486 Query 492 AVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAG 551 AV+ EAVSNAVRH+ AT L + + VEDD+ +EV D+G G+ +T SGL NLR+RA+ AG Sbjct 487 AVVSEAVSNAVRHSRATELTVQIKVEDDLAIEVADNGRGMPEVVTPSGLANLRRRAEQAG 546 Query 552 GEFTVENMPTGGTLLRWSAPL 572 G F +E P GGT++RWSAPL Sbjct 547 GTFGIEAAPGGGTVVRWSAPL 567 >gi|111017071|ref|YP_700043.1| sensor kinase, two-component system [Rhodococcus jostii RHA1] gi|110816601|gb|ABG91885.1| sensor kinase, two-component system [Rhodococcus jostii RHA1] Length=573 Score = 589 bits (1519), Expect = 4e-166, Method: Compositional matrix adjust. Identities = 316/545 (58%), Positives = 404/545 (75%), Gaps = 3/545 (0%) Query 31 EVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYD 90 EVQ+RIEQIV+ RD +DGL++A+LA+TSGL LD TL IVH A LVDARYGALGV G Sbjct 28 EVQERIEQIVDARDHVDGLLEAMLAVTSGLDLDNTLHTIVHAAINLVDARYGALGVLGPG 87 Query 91 HRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPM 150 L EFV+EGIDEETR IG LP GRGVLG LI PKP+RLDD+S H ASVGFP HPPM Sbjct 88 GGLSEFVFEGIDEETRERIGDLPRGRGVLGFLITNPKPVRLDDLSHHSASVGFPAEHPPM 147 Query 151 RTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTR 210 +TFLGVP++IRDEVFGNLYLTEKA+G F++DDEVL++ALAAAAGIA++NARL+EESRTR Sbjct 148 KTFLGVPIQIRDEVFGNLYLTEKANGSQFTEDDEVLLRALAAAAGIAIENARLYEESRTR 207 Query 211 EAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVI 270 +AW+EATR+I T++LAG++ A V ++IA++AL L + +AVP D + P+ EV +LV+ Sbjct 208 QAWLEATREIATELLAGSETAEVLQVIADDALALTGADSAFLAVPDDPDIPSDEVTELVV 267 Query 271 VEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRL--DLAVDGPVEPGPALVLPLRA 328 AG +S + T+ V ++ G F +RTP R L D + GPAL LPLRA Sbjct 268 TASAGTVSDRIIGRTIPVDKSTSGEAFRERTPLRVTALAFDPGFETGTRFGPALALPLRA 327 Query 329 ADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIA 388 A +V GVLV LR D PF+D QL +M+ FADQAA+A +LA +QR+MRE+++L+DRDRIA Sbjct 328 AQSVTGVLVTLRHVDALPFTDDQLALMSGFADQAAVALQLANSQRRMRELDVLSDRDRIA 387 Query 389 RDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPS 448 RDLHDHVIQRLFAVGL+LQ RA+ P V++ + SIDDL +I+++IR+AIFDLH G Sbjct 388 RDLHDHVIQRLFAVGLSLQSTLQRAKAPIVKQRLEQSIDDLHDIVRDIRTAIFDLHGGSG 447 Query 449 RATGLRHRLDKVI-DQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANA 507 T R RL +++ + A L TTV +GPLSV+D LA+HAEAVLREA+SNAVRHA A Sbjct 448 GMTQFRRRLHEIVAETTADSGLRTTVHMSGPLSVIDAALADHAEAVLREALSNAVRHAGA 507 Query 508 TSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLR 567 ++ +++SV DD+ +EV DDG G ++ SGL NL RA + G F ++ P GGT LR Sbjct 508 DTVTVSISVYDDLAIEVADDGKGFVENVVTSGLENLAARAREVNGHFAIDTTPGGGTTLR 567 Query 568 WSAPL 572 W+APL Sbjct 568 WTAPL 572 >gi|226359607|ref|YP_002777385.1| two-component histidine kinase DevS [Rhodococcus opacus B4] gi|226238092|dbj|BAH48440.1| two-component histidine kinase DevS [Rhodococcus opacus B4] Length=576 Score = 583 bits (1503), Expect = 3e-164, Method: Compositional matrix adjust. Identities = 315/545 (58%), Positives = 403/545 (74%), Gaps = 3/545 (0%) Query 31 EVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYD 90 EVQDRI QIV+ RD +DGL++A+LA+TSGL LD TLR IVH A +LVDARYGALGV Sbjct 31 EVQDRIAQIVDVRDHVDGLLEAMLAVTSGLDLDNTLRTIVHAAIDLVDARYGALGVLAPT 90 Query 91 HRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPM 150 L EFVYEGID+ETR IG LP GRGVLG LI +PKP+RL D+SRHP SVGFP HPPM Sbjct 91 EGLSEFVYEGIDQETRERIGDLPRGRGVLGFLITDPKPVRLVDLSRHPVSVGFPPDHPPM 150 Query 151 RTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTR 210 +TFLGVP+++RDEVFGNLYLTEKA+G F++DDEVL++ALAAAAGIA++NARL+EESRTR Sbjct 151 KTFLGVPIQVRDEVFGNLYLTEKANGAQFTEDDEVLLRALAAAAGIAIENARLYEESRTR 210 Query 211 EAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVI 270 +AW+EATR+I T++LAG++ A V ++IA++AL L A + +AVP D + P+ EV +LV+ Sbjct 211 QAWLEATREIATELLAGSETADVLQVIADDALALTAADSAFLAVPDDPDIPSDEVTELVV 270 Query 271 VEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRL--DLAVDGPVEPGPALVLPLRA 328 AG +S + + V ++ G F +RTP R L D + GPAL LPLRA Sbjct 271 TASAGTVSDRIIGRAIPVERSTSGEAFRERTPLRVSALAFDPGFETGARFGPALALPLRA 330 Query 329 ADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIA 388 A +V+GVLV LR D PF+D QL +M+ FADQAA+A +LA +QR+M E+++L+DRDRIA Sbjct 331 AQSVSGVLVTLRHVDASPFTDDQLALMSGFADQAAVALQLANSQRRMHELDVLSDRDRIA 390 Query 389 RDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPS 448 RDLHDHVIQRLFAVGL+LQ RA+ P V++ + SIDDL +I+++IR+AIFDLH G Sbjct 391 RDLHDHVIQRLFAVGLSLQSTLQRAKAPVVKDRLEQSIDDLHDIVRDIRTAIFDLHGGSG 450 Query 449 RATGLRHRLDKVI-DQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANA 507 T R RL +++ + A L TTV +GPLSV+D LA HAEAVLREA+SNAVRHA A Sbjct 451 GITQFRRRLHEIVAETTADSGLRTTVHMSGPLSVIDATLAEHAEAVLREALSNAVRHAGA 510 Query 508 TSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLR 567 ++ +++SV DD+ +EV DDG G G + SGL NL RA + G V++ GGT LR Sbjct 511 DTVTVSISVYDDLAIEVADDGKGFEGSVLTSGLDNLAARAREVNGHCAVDSTLGGGTTLR 570 Query 568 WSAPL 572 WSAPL Sbjct 571 WSAPL 575 >gi|289758147|ref|ZP_06517525.1| LOW QUALITY PROTEIN: GAF sensor signal transduction histidine kinase [Mycobacterium tuberculosis T85] gi|289713711|gb|EFD77723.1| LOW QUALITY PROTEIN: GAF sensor signal transduction histidine kinase [Mycobacterium tuberculosis T85] Length=374 Score = 565 bits (1455), Expect = 9e-159, Method: Compositional matrix adjust. Identities = 314/315 (99%), Positives = 315/315 (100%), Gaps = 0/315 (0%) Query 259 EAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEP 318 +APACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEP Sbjct 60 QAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEP 119 Query 319 GPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREV 378 GPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREV Sbjct 120 GPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREV 179 Query 379 EILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRS 438 EILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRS Sbjct 180 EILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRS 239 Query 439 AIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAV 498 AIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAV Sbjct 240 AIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAV 299 Query 499 SNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVEN 558 SNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVEN Sbjct 300 SNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVEN 359 Query 559 MPTGGTLLRWSAPLR 573 MPTGGTLLRWSAPLR Sbjct 360 MPTGGTLLRWSAPLR 374 >gi|339294953|gb|AEJ47064.1| hypothetical histidine kinase response regulator [Mycobacterium tuberculosis CCDC5079] gi|339298577|gb|AEJ50687.1| hypothetical histidine kinase response regulator [Mycobacterium tuberculosis CCDC5180] Length=301 Score = 540 bits (1391), Expect = 3e-151, Method: Compositional matrix adjust. Identities = 300/301 (99%), Positives = 301/301 (100%), Gaps = 0/301 (0%) Query 273 VAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTV 332 +AGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTV Sbjct 1 MAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTV 60 Query 333 AGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLH 392 AGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLH Sbjct 61 AGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLH 120 Query 393 DHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATG 452 DHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATG Sbjct 121 DHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATG 180 Query 453 LRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAI 512 LRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAI Sbjct 181 LRHRLDKVIDQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAI 240 Query 513 NVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 NVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL Sbjct 241 NVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 300 Query 573 R 573 R Sbjct 301 R 301 >gi|302526810|ref|ZP_07279152.1| predicted protein [Streptomyces sp. AA4] gi|302435705|gb|EFL07521.1| predicted protein [Streptomyces sp. AA4] Length=570 Score = 538 bits (1387), Expect = 7e-151, Method: Compositional matrix adjust. Identities = 308/565 (55%), Positives = 395/565 (70%), Gaps = 9/565 (1%) Query 16 LRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE 75 L TLSQLRLRE L ++Q+RIE ++ RD++DGL++A+LA+ SGL+LDATLR IV A E Sbjct 8 LSGTLSQLRLRETLRDLQERIELLIGTRDKMDGLLEAVLAVASGLELDATLRRIVQAAVE 67 Query 76 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS 135 L +A YGALGV G D L EFVY GID ETR IG LPEG G+LG +I++ KP+RL +IS Sbjct 68 LGEAHYGALGVLGDDGALAEFVYLGIDAETRKRIGHLPEGHGLLGLVIDDAKPLRLTEIS 127 Query 136 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG 195 HPASVGFP +HPPM +FLGVPVR+R+EVFGNLYLTEK DG F+DDDEV+VQALAAAAG Sbjct 128 AHPASVGFPANHPPMHSFLGVPVRVREEVFGNLYLTEKKDGAEFTDDDEVIVQALAAAAG 187 Query 196 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP 255 IA++NA L+E++R R+ W+ AT ++ T++L G DP LIA AL L TL+A+P Sbjct 188 IAIENAHLYEQTRLRQRWLGATSEVTTELLGGTDPVDALELIAGRALELTGSDVTLLALP 247 Query 256 ----LD-DEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDL 310 LD DE + +L + AG + + + V G+ G V+ DRTPRR L L Sbjct 248 GTGRLDVDEDWYADSAELTVTVCAGGDVRDLTGLRMPVDGSVPGAVYRDRTPRRMAELAL 307 Query 311 AVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLAT 370 D GPALV+PLRA D +GVL+ALR F QL ++A+FADQAALA +LA+ Sbjct 308 LPD--RGRGPALVVPLRAGDHTSGVLIALREPGSALFETAQLPVLASFADQAALALQLAS 365 Query 371 AQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQ 430 QR RE ++L+DRDRIARDLHDHVIQRLFAVGL +Q RA+ P ++ + SID + Sbjct 366 QQRAARERDVLSDRDRIARDLHDHVIQRLFAVGLAMQSTQRRAKTPELQRRLQESIDQMH 425 Query 431 EIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAIPA-LHTTVQYTGPLSVVDTVLANH 489 EI++EIR+AIFDLH G + LR+RL I +L A LH V GPL V LA H Sbjct 426 EIVREIRTAIFDLHGGAAGEARLRNRLHDAIAELTDDAPLHPAVSMAGPLDAVPAQLAEH 485 Query 490 AEAVLREAVSNAVRHANATSLAINVSVEDD-VRVEVVDDGVGISGDITESGLRNLRQRAD 548 EAV+REAVSNAVRHA A++L+++V+V D+ VR+ V DDG G+ +++ SGL NLR+RA+ Sbjct 486 VEAVVREAVSNAVRHAGASALSVSVAVRDEVVRISVTDDGTGLPEEVSPSGLGNLRERAE 545 Query 549 DAGGEFTVENMPTGGTLLRWSAPLR 573 AGGEF + + P GG + WSAPLR Sbjct 546 SAGGEFVLGSGPGGGVRVEWSAPLR 570 >gi|317507620|ref|ZP_07965333.1| GAF domain-containing protein [Segniliparus rugosus ATCC BAA-974] gi|316254097|gb|EFV13454.1| GAF domain-containing protein [Segniliparus rugosus ATCC BAA-974] Length=569 Score = 527 bits (1358), Expect = 2e-147, Method: Compositional matrix adjust. Identities = 289/556 (52%), Positives = 384/556 (70%), Gaps = 5/556 (0%) Query 18 ETLSQLRLRELLLEVQDRIEQIV-EGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAEL 76 E L+Q +LRELL+E+Q+RIE+IV + + R+ GL+DA++A++SGL+LD TL IV A +L Sbjct 8 EGLAQTQLRELLVEIQERIEEIVADSQTRMAGLLDAVVAVSSGLELDVTLHKIVRAAIDL 67 Query 77 VDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISR 136 V+ARYGALGV G D L +FV+ GIDE TR LIG LP GRGVLG +I+E KP+RL DIS Sbjct 68 VNARYGALGVLGRDGTLSQFVHVGIDEATRELIGPLPTGRGVLGVVIDEAKPLRLADISE 127 Query 137 HPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGI 196 HPAS+GFP +HPPMRTFLGVPV +R +VFG LYL EK G F++DDEV+V+ LA+AAGI Sbjct 128 HPASIGFPPNHPPMRTFLGVPVEVRGQVFGRLYLAEKHGGHQFTEDDEVVVRTLASAAGI 187 Query 197 AVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPL 256 A++NARL+ ++R R+ W++AT +I ++L G D RLIA + +L+ L+A+P Sbjct 188 AIENARLYAQARKRQQWLQATAEITAELLRGTDLPQALRLIAVRSASLVGADYALIALPD 247 Query 257 DDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFD--RLDLAVDG 314 D A EV +L V +G + MTV V G++ G VF +R PR LDL+ Sbjct 248 DLLAGPEEVQELRFVACSGLDERTMIGMTVPVEGSTSGTVFQNRAPRSVSALALDLSEQT 307 Query 315 PVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQ 374 + GPALVLPLR+A++V GVL+ +RSA PF + QLD +A+FADQAALA A + Sbjct 308 GIAFGPALVLPLRSAESVTGVLLLIRSAGAAPFGEDQLDAVASFADQAALALEQAEIRSA 367 Query 375 MREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRA-RVPAVRESIYSSIDDLQEII 433 E+++L +RDRIARDLHDHVIQ+LFA+GL++Q R+ R+P V + +D L +II Sbjct 368 KHELDVLAERDRIARDLHDHVIQQLFAIGLSMQSTQRRSQRIPEVAGRLTEHVDQLHDII 427 Query 434 QEIRSAIFDLHAGPSRATGLRHRLDKVIDQLA-IPALHTTVQYTGPLSVVDTVLANHAEA 492 Q+IR+AIFDLHA T LR + V+ +L L TV TGPL VV +A EA Sbjct 428 QDIRTAIFDLHAANRGETSLRSSVRAVVAKLTDDSGLRVTVHMTGPLDVVPESIARDGEA 487 Query 493 VLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGG 552 VLREAVSNAVRHA+A+ L++ VSV+D +EVVD+GVGI + SGLRNL +RA GG Sbjct 488 VLREAVSNAVRHASASELSVAVSVDDHFVIEVVDNGVGIPEAVAHSGLRNLAERALAHGG 547 Query 553 EFTVENMPTGGTLLRW 568 +F ++ TGGT L W Sbjct 548 QFEAASVATGGTRLFW 563 >gi|326385155|ref|ZP_08206823.1| sensor kinase, two-component system [Gordonia neofelifaecis NRRL B-59395] gi|326196120|gb|EGD53326.1| sensor kinase, two-component system [Gordonia neofelifaecis NRRL B-59395] Length=576 Score = 527 bits (1357), Expect = 2e-147, Method: Compositional matrix adjust. Identities = 295/569 (52%), Positives = 387/569 (69%), Gaps = 4/569 (0%) Query 8 NVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLR 67 N S R LSQ+RL EL+ E+Q+R+ QI + R+ L++A+LA+T+GL+L+ TL+ Sbjct 7 NARERSREFRSALSQMRLSELVDELQERLTQITDFPRRMAALMEAMLAVTTGLRLEDTLQ 66 Query 68 AIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPK 127 ++V AA LVDA YGALGVRG DH L FV +GIDE+T L+G P GRGVLG LI+EPK Sbjct 67 SVVGAAARLVDAEYGALGVRGEDHHLSAFVNQGIDEDTVALLGPPPTGRGVLGVLIDEPK 126 Query 128 PIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLV 187 +RLDD+SRHP SVGFP HHPPM TFLG P+R+RD+VFGNLYLTEK G PF+DDDEV++ Sbjct 127 VLRLDDLSRHPDSVGFPPHHPPMTTFLGAPIRVRDKVFGNLYLTEKRGGGPFTDDDEVII 186 Query 188 QALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAG 247 ALA+ AGIA+DNARL+E+S+ + WIEATRD+ T++L+GA+ V R++A +ALTL Sbjct 187 VALASIAGIAIDNARLYEQSQLQLGWIEATRDVRTELLSGAENRDVLRMLARKALTLTDA 246 Query 248 AATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDR 307 VA P D E PA V +L++ G S + T+ V+G++ G F R P R DR Sbjct 247 DLVFVAQPDDPEHPADMVRELIVTVAEGRSSGDEEGATIPVAGSTSGAAFTRREPIRRDR 306 Query 308 LDLAV--DGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALA 365 L+ D GP L PLRAADT +GVLV LR+ FSD L++ A FADQAALA Sbjct 307 LEYTRIDDIGTRYGPVLAAPLRAADTTSGVLVILRNVGRPQFSDHLLELCAGFADQAALA 366 Query 366 WRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSS 425 LA Q R+VE+L DR+RIA DLHDHVIQR+FA G+ LQ R VR + S Sbjct 367 LELAARTTQARQVEMLADRERIANDLHDHVIQRIFAEGMALQATLQRTASADVRARLTRS 426 Query 426 IDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVID-QLAIPALHTTVQYTGPLSVVDT 484 +D+LQ+++QEIRS IFDLH+ + T LR R+ V+D Q+ L T ++ +GPLSVV Sbjct 427 VDNLQDVVQEIRSTIFDLHSDDTATTRLRQRIHDVVDEQVGDAPLETHIRLSGPLSVVAP 486 Query 485 VLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLR 544 +A AVLREAVSN VRHA+A ++ + VSV D++ +EVVDDGVG+ DIT SGL ++R Sbjct 487 DVAEQLVAVLREAVSNVVRHAHACTMTVAVSVGDEITLEVVDDGVGLPDDITPSGLASMR 546 Query 545 QRADDAGGEFTVENMPTG-GTLLRWSAPL 572 +RA+ GE ++ G ++RWS PL Sbjct 547 RRAESLSGELSLTPADDARGLVVRWSVPL 575 >gi|343925109|ref|ZP_08764641.1| two-component histidine kinase DevS [Gordonia alkanivorans NBRC 16433] gi|343765040|dbj|GAA11567.1| two-component histidine kinase DevS [Gordonia alkanivorans NBRC 16433] Length=575 Score = 523 bits (1347), Expect = 4e-146, Method: Compositional matrix adjust. Identities = 280/566 (50%), Positives = 385/566 (69%), Gaps = 6/566 (1%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 GS ++ LSQ+RLRELL EV+DRI QI + RDR+DGL++A+L ++S L L+ TL AIV Sbjct 11 GSFEVQNELSQMRLRELLDEVRDRITQIADVRDRIDGLLEAMLMVSSDLDLETTLEAIVS 70 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 LVDA YGA+GV G H L F+ +GI E+ R IG LP GRGVLG LI++P+ +RL Sbjct 71 AGTRLVDAEYGAVGVLGSGHDLSAFLAQGIGEDVRAEIGHLPTGRGVLGQLIDDPRVLRL 130 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 D+S HPASVGFP +HPPM +FLG P+R+RDE+FGNLYLTEK +G F++DDE+++QALA Sbjct 131 TDLSEHPASVGFPPNHPPMTSFLGAPIRVRDEIFGNLYLTEKKNGALFTEDDELVIQALA 190 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 +AAGIA++NARL+E+++T+ AWIEA RD+ ++L GAD V IA + LTL Sbjct 191 SAAGIAIENARLYEQAQTQLAWIEANRDVIAELLTGADQQDVLESIARKVLTLADADLVC 250 Query 252 VAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTP--RRFDRLD 309 +A P D E PA V++LV+ G + + TV + G++ G F R P R D Sbjct 251 IAEPHDHEMPAESVEELVVTVAEGVDAEVFRGRTVPIKGSTSGDAFVRRRPVLREELEYD 310 Query 310 LAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLA 369 ++ D + GP +V PLR A++ GVL+A+RS F++ L + A FADQ ALA +LA Sbjct 311 ISGDSSTQHGPVMVAPLRTAESTRGVLIAVRSKGRDGFAEDLLSLSANFADQGALALQLA 370 Query 370 TAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDL 429 +A Q E+ +L DR+RIARDLHDHVIQR+FA GLTLQ R + +R + SI++L Sbjct 371 SATNQAHEMRVLEDRERIARDLHDHVIQRIFAEGLTLQATLQRTQSSEIRARLTRSINNL 430 Query 430 QEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLA--IPALHTTVQYTGPLSVVDTVLA 487 Q+I+Q++RS IFDL A + T LR R+ + IDQ +P + T V+ GPLS+V+ LA Sbjct 431 QDIVQDVRSTIFDLQAEETETTRLRQRVQETIDQQIDDLP-IQTHVRMAGPLSIVEPRLA 489 Query 488 NHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRA 547 + AV+REA+SNAVR+A+AT++ + +SV D++ VEV DDGVG+ D+T SGL+NLR RA Sbjct 490 DQVVAVVREALSNAVRYAHATTVTVAISVGDELAVEVTDDGVGLPEDVTPSGLKNLRHRA 549 Query 548 DDAGGEFTVENMPTG-GTLLRWSAPL 572 GG F + +G G +RW+ PL Sbjct 550 KQLGGAFALNTPDSGRGLSVRWAVPL 575 >gi|169630969|ref|YP_001704618.1| histidine kinase response regulator [Mycobacterium abscessus ATCC 19977] gi|169242936|emb|CAM63964.1| Probable histidine kinase response regulator [Mycobacterium abscessus] Length=567 Score = 517 bits (1332), Expect = 2e-144, Method: Compositional matrix adjust. Identities = 302/567 (54%), Positives = 380/567 (68%), Gaps = 12/567 (2%) Query 12 GSPPLRET--LSQLRLRELLLEVQDRIEQIVEG-RDRLDGLIDAILAITSGLKLDATLRA 68 G+ P R T L+ L+LRELL EVQ RIEQIV+G R R+D L+DA++A++SGL+LDATLR Sbjct 6 GAQPNRVTAELAHLQLRELLAEVQGRIEQIVDGTRGRMDALLDAVMAVSSGLELDATLRE 65 Query 69 IVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKP 128 IV A+ELV ARYGALGV G D +L EFVYEGIDE TR LIG LP G GVLG +I+E KP Sbjct 66 IVCAASELVSARYGALGVVGSDEKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKP 125 Query 129 IRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQ 188 +RL DI+ HPASVGFP +HPPMRTFLGVPV++R EVFG LYLTEK DGQ F++DDEV+V+ Sbjct 126 LRLRDIAAHPASVGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVR 185 Query 189 ALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGA 248 ALA AAGIA++NARL++ +R RE W AT DI ++L G DP L+A A L Sbjct 186 ALAGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPGKALHLVASSAALLAEAD 245 Query 249 ATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRL 308 +A+P DE E LV+ G+ + + + + G++ G F D PR RL Sbjct 246 FAFIALPAGDEEDTAE---LVVAVCEGKGAEVLNDKLIPIDGSTSGSTFIDHEPRNVGRL 302 Query 309 --DLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAW 366 +LA + GPALVLPL ++ AGVL+ LR+ F ++QLDM A+FA QAALA Sbjct 303 AVNLAEGTDLAFGPALVLPLGGGESTAGVLILLRTVGAIAFDEEQLDMAASFAGQAALAL 362 Query 367 RLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSI 426 A + E+++L DRDRIARDLHDHVIQRLFAVGL +Q R+ P V + I Sbjct 363 EQAEVRLAKHELDVLADRDRIARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHI 422 Query 427 DDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQL-AIPALHTTVQYTGPLSVVDTV 485 D L E+IQEIR+AIFDLH + LR L I++L A L +V+ +GPL VV Sbjct 423 DQLHEVIQEIRTAIFDLH---TNDESLRATLRSTINELTAETGLRVSVRMSGPLDVVPAS 479 Query 486 LANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQ 545 + AEAV+REAVSN VRHA A L++ VSV+D++ +EVVDDG+GI + SGL L Sbjct 480 TSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGIPDVVARSGLSGLAN 539 Query 546 RADDAGGEFTVENMPTGGTLLRWSAPL 572 RA +GG F+V M TGGT L WSAPL Sbjct 540 RAAQSGGTFSVSAMDTGGTRLVWSAPL 566 >gi|258652223|ref|YP_003201379.1| GAF sensor signal transduction histidine kinase [Nakamurella multipartita DSM 44233] gi|258555448|gb|ACV78390.1| GAF sensor signal transduction histidine kinase [Nakamurella multipartita DSM 44233] Length=595 Score = 514 bits (1323), Expect = 2e-143, Method: Compositional matrix adjust. Identities = 299/561 (54%), Positives = 385/561 (69%), Gaps = 4/561 (0%) Query 14 PPLRETLSQLRLRELLLEVQDRIEQIV-EGRDRLDGLIDAILAITSGLKLDATLRAIVHT 72 P + + LSQ RLRELL EV DR+E IV + R+R+D L+DA+LA++SGL D TLR IV Sbjct 36 PQVGQRLSQERLRELLDEVGDRVEGIVSDTRERMDALLDAVLAVSSGLDQDVTLRQIVQA 95 Query 73 AAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLD 132 A ELVDAR+GALGV G L +FV+ GID++TR LIG LP G GVLG +IEE KP+RL Sbjct 96 AIELVDARFGALGVLGEGGMLSKFVHVGIDDQTRELIGPLPTGHGVLGVVIEENKPLRLA 155 Query 133 DISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAA 192 D+S+HP S+GFP HHPPMRTFLGVPVR R E FG LYLTEK +G+ F+ DDEV+V ALA Sbjct 156 DLSQHPMSIGFPPHHPPMRTFLGVPVRARGETFGRLYLTEKRNGEEFTFDDEVVVSALAG 215 Query 193 AAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLV 252 AAGIA+DNARL+E +R R+AW+EAT ++ Q+L G+D RLIA A L T++ Sbjct 216 AAGIAIDNARLYEAARQRQAWLEATGEVTAQLLGGSDTEEALRLIASRARELTKADHTMI 275 Query 253 AVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAV 312 A+P++ A E +LVI G S + V V+G+++G VF DR PR RLD + Sbjct 276 ALPVEPADGAAEPGELVIAVSVGLDSVELTGRRVPVAGSTMGTVFLDRLPRNVLRLDFDL 335 Query 313 DGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQ 372 G + GPA+VLPL + ++GVL+ +R F +++L++++ FADQAALA A +Q Sbjct 336 TG--QFGPAMVLPLGTGEQISGVLLTVRRPGSDQFDEQELNLVSTFADQAALALDRAESQ 393 Query 373 RQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEI 432 RE+E+L DRDRIARDLHDHVIQRLFA+GL +Q R + P + ID L ++ Sbjct 394 LARREMEVLEDRDRIARDLHDHVIQRLFAIGLGMQSTHRREKSPHQAARLADHIDQLHDV 453 Query 433 IQEIRSAIFDLHAGPSRATGLRHRLDKVIDQL-AIPALHTTVQYTGPLSVVDTVLANHAE 491 IQEIR+AIFDL AGP++ GLR L++VI L AL TTV+ +GPL V+ LA + Sbjct 454 IQEIRTAIFDLQAGPAQEPGLRSALNQVISDLTGDAALRTTVRMSGPLDVIPPDLAQDVQ 513 Query 492 AVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAG 551 A LREAVSNAVRHA AT L I VSVEDD+ ++V D+GVG+ + SGL NL +RA AG Sbjct 514 AALREAVSNAVRHAQATELIITVSVEDDLVMDVTDNGVGLPETVARSGLHNLGRRAAAAG 573 Query 552 GEFTVENMPTGGTLLRWSAPL 572 G +V P GGT L W+APL Sbjct 574 GALSVTRPPAGGTRLIWTAPL 594 >gi|289746020|ref|ZP_06505398.1| histidine kinase response regulator [Mycobacterium tuberculosis 02_1987] gi|289686548|gb|EFD54036.1| histidine kinase response regulator [Mycobacterium tuberculosis 02_1987] Length=270 Score = 511 bits (1316), Expect = 1e-142, Method: Compositional matrix adjust. Identities = 257/259 (99%), Positives = 259/259 (100%), Gaps = 0/259 (0%) Query 1 VTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 +THPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL Sbjct 1 MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGL 60 Query 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG Sbjct 61 KLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLG 120 Query 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS Sbjct 121 ALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFS 180 Query 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE Sbjct 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 Query 241 ALTLMAGAATLVAVPLDDE 259 ALTLMAGAATLVAVPLDD+ Sbjct 241 ALTLMAGAATLVAVPLDDK 259 >gi|54024863|ref|YP_119105.1| putative two-component system sensor kinase [Nocardia farcinica IFM 10152] gi|54016371|dbj|BAD57741.1| putative two-component system sensor kinase [Nocardia farcinica IFM 10152] Length=583 Score = 511 bits (1316), Expect = 1e-142, Method: Compositional matrix adjust. Identities = 302/572 (53%), Positives = 400/572 (70%), Gaps = 10/572 (1%) Query 11 PGS---PPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLR 67 PGS PP+ ETL+Q RLRELL EVQDRI +IV RD++D LI+A+L +T+GL LD TLR Sbjct 11 PGSNDRPPVIETLAQSRLRELLAEVQDRIAEIVNVRDQMDRLIEAMLVVTAGLDLDNTLR 70 Query 68 AIVHTAAELVDARYGALGVRGYD---HRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIE 124 +IVHTA ELVDA+YGALGVR D L EFVYEGID+ TR LIG LP G GVLG LI+ Sbjct 71 SIVHTAIELVDAKYGALGVRESDRDSKELAEFVYEGIDDRTRVLIGDLPRGHGVLGLLID 130 Query 125 EPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDE 184 +P+PIRL D+S HPASVGFP HHPPMRTFLGVPV++ EVFGNLYLTEKA G F++DDE Sbjct 131 DPRPIRLADMSAHPASVGFPDHHPPMRTFLGVPVQVGGEVFGNLYLTEKAGGHEFTEDDE 190 Query 185 VLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTL 244 V+VQALAAAAGIA+ NARL+EESR R+ W+EAT+ + T++LAG + + VF +I E AL L Sbjct 191 VVVQALAAAAGIAIANARLYEESRIRQQWLEATQQVATRLLAGGETSEVFTVITERALAL 250 Query 245 MAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRR 304 A +A+P D + P ++ +LV+V AG + + + + T G F D P Sbjct 251 TGSACAFLALPEDPDVPPEDLTELVVVAAAGADADTLTGTRLPMDETHTGVAFRDGRPLA 310 Query 305 FDRLDL-AVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAA 363 D D + +E GP L LPLRA + V G+L +R+ P MM+AFADQAA Sbjct 311 VDTADAPSFATSLEYGPVLTLPLRAGNAVVGLLTTMRALGMPPVDAAGQAMMSAFADQAA 370 Query 364 LAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIY 423 LA ++A QR+MRE++++++RDRIARDLHDHVIQRLFAVGL+LQ RAR P ++ + Sbjct 371 LALQMAATQRRMRELDVVSERDRIARDLHDHVIQRLFAVGLSLQSTVSRARAPEIKTRLM 430 Query 424 SSIDDLQEIIQEIRSAIFDLHAGP-SRATGLRHRLDKVIDQLAIPA-LHTTVQYTGPLSV 481 +++D+Q I+QEIR +IFDLH+ + A LR RL V+ ++ L T+++ +GP+SV Sbjct 431 DTVNDVQSIVQEIRHSIFDLHSSSAAEAPALRKRLHAVLAEMTEETDLRTSIRLSGPVSV 490 Query 482 VDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDIT-ESGL 540 + + + EAVLREAVSN VRHA A+SL++ +++ DDV +E+VD+G+G+ D+ SGL Sbjct 491 LAPAMFDDVEAVLREAVSNVVRHAKASSLSVRLTIRDDVELEIVDNGIGLPEDLPRRSGL 550 Query 541 RNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 N+ R + AGG F E GGT++ WS PL Sbjct 551 ANMAARTEKAGGTFRAERGRDGGTVIHWSVPL 582 >gi|300787342|ref|YP_003767633.1| two-component system sensor kinase [Amycolatopsis mediterranei U32] gi|299796856|gb|ADJ47231.1| two-component system sensor kinase [Amycolatopsis mediterranei U32] gi|340528850|gb|AEK44055.1| two-component system sensor kinase [Amycolatopsis mediterranei S699] Length=583 Score = 500 bits (1287), Expect = 3e-139, Method: Compositional matrix adjust. Identities = 303/570 (54%), Positives = 396/570 (70%), Gaps = 12/570 (2%) Query 12 GSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVH 71 GS + TLS LRLRE+L ++QDRIE ++ RD++DGL+DA+LA+ SGL+LD TLR IV Sbjct 16 GSRRMAGTLSGLRLREVLRDLQDRIELLIGTRDKMDGLLDAVLAVASGLELDTTLRRIVL 75 Query 72 TAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRL 131 A EL +A+YGALGV D + EF+Y GI++ETR LIG LP G GVLG +I+E KP+R+ Sbjct 76 AAIELGEAKYGALGVLADDGSMSEFIYVGIEDETRRLIGDLPTGHGVLGVVIDEAKPLRM 135 Query 132 DDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALA 191 ++IS HPASVGFP HHPPM +FLGVPVR+RDEVFG LYLTEK +G+PF+DDDEV+VQALA Sbjct 136 EEISSHPASVGFPAHHPPMHSFLGVPVRVRDEVFGRLYLTEKKNGEPFTDDDEVVVQALA 195 Query 192 AAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATL 251 AAAGIA++NA L+E++R R+ W+ AT ++ T++L G DPA LIA AL L T+ Sbjct 196 AAAGIAIENAHLYEQARVRQQWLAATSEVTTELLGGTDPAEALNLIASRALELTGSDVTM 255 Query 252 VAVP-----LDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFD 306 +A+P DE +VDDL + AG + + M + + + G V+ DRTPR Sbjct 256 LALPNSGRLDVDEDWGDDVDDLTVTVSAGTRAAELSGMHIGLEESVPGAVYQDRTPRNVG 315 Query 307 RLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAW 366 L L GPALV+PLRA D GVL+A R F QL ++A+FADQAALA Sbjct 316 ELRLPDH---RFGPALVVPLRAGDRTTGVLIAARQTGAGSFESAQLPVLASFADQAALAL 372 Query 367 RLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSI 426 +LA QR RE+++L DRDRIARDLHDHVIQRLFAVGL++Q R + P +++ + SI Sbjct 373 QLAAQQRAARELDVLGDRDRIARDLHDHVIQRLFAVGLSMQSTQRRTKSPELQKRLGDSI 432 Query 427 DDLQEIIQEIRSAIFDLHAGPSRATG--LRHRLDKVIDQLAIPA-LHTTVQYTGPLSVVD 483 + + EI+QEIR+AIFDLH G + TG LRHRL I +L A +H TV +G + V Sbjct 433 EQMHEIVQEIRTAIFDLHGGAAGETGLRLRHRLHDAIAELTDDAPVHPTVSMSGSIDTVP 492 Query 484 TVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDV-RVEVVDDGVGISGDITESGLRN 542 LA HAEAV+REAVSNAVRHA A++L+++V+V+DDV R+ V DDG G+ D++ SGL N Sbjct 493 AQLAEHAEAVVREAVSNAVRHAEASTLSVSVAVKDDVLRIVVADDGRGLPEDVSPSGLGN 552 Query 543 LRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 L RA+ GG FT+ P GG + WSAP+ Sbjct 553 LGDRAEAVGGAFTLGRGPDGGVKVEWSAPV 582 >gi|296394764|ref|YP_003659648.1| GAF sensor signal transduction histidine kinase [Segniliparus rotundus DSM 44985] gi|296181911|gb|ADG98817.1| GAF sensor signal transduction histidine kinase [Segniliparus rotundus DSM 44985] Length=561 Score = 486 bits (1251), Expect = 4e-135, Method: Compositional matrix adjust. Identities = 289/562 (52%), Positives = 368/562 (66%), Gaps = 7/562 (1%) Query 16 LRETLSQLRLRELLLEVQDRIEQIVEG-RDRLDGLIDAILAITSGLKLDATLRAIVHTAA 74 + E L QL+LRELL EVQ+RIEQIV R+R++GL +A++A++SGL+ D TLR IV A Sbjct 1 MTEGLGQLQLRELLAEVQERIEQIVANTRNRMEGLFEAVVAVSSGLEFDLTLRQIVRAAI 60 Query 75 ELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDI 134 +LV A +GALGV G D L EFV+EGIDEE R LIG LP GRG+LGA+ E K RL DI Sbjct 61 KLVGAEHGALGVLGPDGMLTEFVHEGIDEEARKLIGPLPTGRGMLGAMAEGSKTQRLVDI 120 Query 135 SRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAA 194 + HPAS+GFP +HP M TFLGVPV++R EVFG LYLT K DGQ F+ DDEV+V+ALA AA Sbjct 121 AAHPASIGFPANHPSMSTFLGVPVKVRGEVFGRLYLTGKKDGQQFTKDDEVVVRALAVAA 180 Query 195 GIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAV 254 GIAV+NARL+EE+R R+ + A+ ++ ++L G PA V RLIA A L+ L+A+ Sbjct 181 GIAVENARLYEEARRRQQQLRASAEVTAELLGGTAPAQVLRLIASRAAELVDADHALIAL 240 Query 255 PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAV-D 313 P PA + V V + G + + MT+ V + G VF DRTPR L L + D Sbjct 241 PRGAAQPAHTAELAVAVHI-GPCAHEMTGMTIPVDRSVPGAVFCDRTPRNVPELALGLPD 299 Query 314 GPVEP-GPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQ 372 G V GPAL LPLRA ++ AGVL+ +R A F +QLD+ A+FA+QAALA A + Sbjct 300 GKVVTLGPALALPLRAGESTAGVLLLIRDAGGAGFDMEQLDIGASFAEQAALALEQAEIR 359 Query 373 RQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPR-ARVPAVRESIYSSIDDLQE 431 E+E+L DRDRIARDLHDHVIQRLF +GL +Q R A+ PAV E + ID + E Sbjct 360 SAKHELEMLADRDRIARDLHDHVIQRLFVIGLGMQSTHRRAAKTPAVAERLTEHIDRIHE 419 Query 432 IIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQL-AIPALHTTVQYTGPLSVVDTVLANHA 490 +I+EIR+AIFDLH LR L K I +L AL V+ GPL VV +A HA Sbjct 420 VIEEIRTAIFDLHTA-GDGVALRVVLHKAIAELTGDSALRVAVRMAGPLDVVPEEIAVHA 478 Query 491 EAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDA 550 EAV+REAV+N +RHA AT L+I V+V D ++V D+G G+ + SGL NL RA Sbjct 479 EAVVREAVTNVLRHAGATELSITVTVGGDFVIDVADNGKGVPEVVARSGLHNLADRASAC 538 Query 551 GGEFTVENMPTGGTLLRWSAPL 572 G V + TGGT L W+APL Sbjct 539 CGSLAVTRLQTGGTRLVWTAPL 560 >gi|226306907|ref|YP_002766867.1| two-component histidine kinase DevS [Rhodococcus erythropolis PR4] gi|226186024|dbj|BAH34128.1| two-component histidine kinase DevS [Rhodococcus erythropolis PR4] Length=563 Score = 483 bits (1242), Expect = 5e-134, Method: Compositional matrix adjust. Identities = 266/533 (50%), Positives = 359/533 (68%), Gaps = 3/533 (0%) Query 43 RDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGID 102 R +DGL++A+LA+++GL LD TLR IV +A LVDA++GALGV G L +FVYEGID Sbjct 26 RIHVDGLLEALLAVSAGLDLDTTLRTIVKSAIALVDAKFGALGVVGDSEELKQFVYEGID 85 Query 103 EETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRD 162 E R LIG LP GRGVLGALI +PKP+RLDD+S+H ASVGFP HHPPM+TFLGVP++ R Sbjct 86 ETGRELIGDLPRGRGVLGALISDPKPLRLDDLSKHEASVGFPDHHPPMKTFLGVPIQTRG 145 Query 163 EVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGT 222 +VFGNLYLTEK +G+ F+ DE++V ALA+AA IA+DN++L+ ++ ++ W+ AT ++ T Sbjct 146 QVFGNLYLTEKTNGRAFTAHDEMIVLALASAASIAIDNSQLYALTKMKQEWLLATGEVTT 205 Query 223 QMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVK 282 +LAGAD V +LIA+++L+L + +AVP D E +LV+ +G S + Sbjct 206 ALLAGADALGVLQLIADKSLSLTSSDCAFLAVPPDPELTGVATAELVVTVASGLDSETLV 265 Query 283 QMTVAVSGTSIGGVFHDRTPRRFDRLDL--AVDGPVEPGPALVLPLRAADTVAGVLVALR 340 + + ++ G V+ ++ P + L+ E GPA+VLPLR V GVL L+ Sbjct 266 GHGIPLDFSTSGAVYRNKFPIVTESLEFDPGFGEGHEYGPAIVLPLRDGQQVRGVLAVLK 325 Query 341 SADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLF 400 + + QL M+AFADQ A+A RLA QR+M E++IL DRDRIARDLHDHVIQR+F Sbjct 326 LRGAEQYGADQLASMSAFADQGAVALRLADNQRRMAELDILADRDRIARDLHDHVIQRIF 385 Query 401 AVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKV 460 AVGL++QG R R P V + + +IDDLQ+IIQ+IR AIFDLHA A LR RL++V Sbjct 386 AVGLSVQGTLQRTRAPEVHQRLSGTIDDLQDIIQDIRRAIFDLHATEDGAPSLRSRLNQV 445 Query 461 IDQLAIPA-LHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDD 519 + + + L TVQ GPLSVVD L AEAV+REA+SN VRHA A+++AI + V D Sbjct 446 VAETSADTDLRVTVQVRGPLSVVDPSLGEQAEAVVREALSNVVRHAQASTVAIVIDVHDS 505 Query 520 VRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 + V + DDG+G+ GL+NL +RA GG F ++ GGT L WS PL Sbjct 506 LTVTIADDGIGLPPGAHRRGLKNLCERAFALGGTFDAQSTDGGGTTLVWSVPL 558 >gi|339294954|gb|AEJ47065.1| histidine kinase response regulator [Mycobacterium tuberculosis CCDC5079] gi|339298578|gb|AEJ50688.1| histidine kinase response regulator [Mycobacterium tuberculosis CCDC5180] Length=255 Score = 479 bits (1232), Expect = 7e-133, Method: Compositional matrix adjust. Identities = 242/244 (99%), Positives = 244/244 (100%), Gaps = 0/244 (0%) Query 16 LRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE 75 +RETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE Sbjct 1 MRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAE 60 Query 76 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS 135 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS Sbjct 61 LVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDIS 120 Query 136 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG 195 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG Sbjct 121 RHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAG 180 Query 196 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP 255 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP Sbjct 181 IAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVP 240 Query 256 LDDE 259 LDD+ Sbjct 241 LDDK 244 >gi|240171513|ref|ZP_04750172.1| two-component sensor histidine kinase [Mycobacterium kansasii ATCC 12478] Length=549 Score = 426 bits (1094), Expect = 7e-117, Method: Compositional matrix adjust. Identities = 249/543 (46%), Positives = 337/543 (63%), Gaps = 5/543 (0%) Query 35 RIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLV 94 ++++++ RD++ L+ I+ I S L LD TLR IV A EL A YGAL VR + L+ Sbjct 4 QLDELLAARDQMAQLLRVIVEIGSDLDLDGTLRRIVTAARELTAAPYGALAVRDPEGTLL 63 Query 95 EFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFL 154 F++EGID E IG LP G+GVLG + E +RLDD++ HPA+ GFP HHPPMR FL Sbjct 64 SFIHEGIDAEMARRIGHLPVGKGVLGVSLVETPALRLDDLTAHPAACGFPEHHPPMRAFL 123 Query 155 GVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWI 214 GVP+ IR VFG+LYLT G+ FS+ DE L +ALA AAG+A+DNA++ E RT W+ Sbjct 124 GVPIMIRGTVFGHLYLTHVDPGRVFSESDEFLARALAFAAGVAIDNAQVLERERTAVKWM 183 Query 215 EATRDIGTQMLAGADPA-MVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEV 273 EA+R+I T +L A+P RLIAE+A L +V VPLD + P E+D LV+ Sbjct 184 EASREITTALLTSAEPQRRPLRLIAEKACALTDAEQAIVLVPLDADQPPDEIDTLVVSAA 243 Query 274 AGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDG--PVEPGPALVLPLRAADT 331 G + V V V G++ G VF P + + + V A+++PLRA D Sbjct 244 VGRHAAEVVGQRVPVDGSTTGTVFRSGQPLITEAFNHRIPAFTDVAQRSAILMPLRAHDH 303 Query 332 VAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDL 391 VAGV+ R AD+ PF +D+++ FA AA+A LA+ + R++ IL +R+RIA DL Sbjct 304 VAGVIAIARGADKPPFDVSYVDLVSNFATHAAIALMLASGREDARQLTILAERERIAHDL 363 Query 392 HDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRAT 451 HDHVIQRLFA G+ LQG RAR P V + ++DDLQ II+EIR+AIF L A R Sbjct 364 HDHVIQRLFATGMDLQGTLARARSPEVIGRLSRTLDDLQTIIEEIRTAIFQLKAPLERDG 423 Query 452 GLRHRLDKVIDQLAIPA-LHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSL 510 G RHR+ V+ L + TTVQ GP++ V LA+HAEAV EAVSNA+RH+ AT L Sbjct 424 GFRHRIQAVVADLTEHRDIVTTVQIDGPMAAVGDELADHAEAVTTEAVSNALRHSGATQL 483 Query 511 AINVSVEDDVRVEVVDDGVGISGDIT-ESGLRNLRQRADDAGGEFTVENMPTGGTLLRWS 569 I V V D +++VD+G G+ DI+ SGL N++ RA+ GG + + P GGT + W+ Sbjct 484 TIEVGVADMFSLDIVDNGCGLPADISRRSGLANMKHRAEQLGGSCEINSAPDGGTRVHWT 543 Query 570 APL 572 APL Sbjct 544 APL 546 >gi|256376041|ref|YP_003099701.1| GAF sensor signal transduction histidine kinase [Actinosynnema mirum DSM 43827] gi|255920344|gb|ACU35855.1| GAF sensor signal transduction histidine kinase [Actinosynnema mirum DSM 43827] Length=566 Score = 415 bits (1066), Expect = 1e-113, Method: Compositional matrix adjust. Identities = 259/567 (46%), Positives = 359/567 (64%), Gaps = 29/567 (5%) Query 20 LSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDA 79 L+ LRL ELL E+++R+ +I RD++ L+DA+LA+ +GL+LD+TL+ IV A +LV A Sbjct 14 LAGLRLDELLEEMRERLTEIGSTRDKMQRLLDAVLAVGTGLELDSTLQRIVQAAVDLVGA 73 Query 80 RYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPA 139 RYGALGV G L EFV+ GID++ R +G LP+G+G+LG LI++P+P+RL D+ HPA Sbjct 74 RYGALGVLGNRDDLSEFVHVGIDQDERARMGHLPQGKGLLGLLIKDPRPVRLHDLGAHPA 133 Query 140 SVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVD 199 SVG P +HPPM+TFLGVPVR+RDEVFGNLY+ EK DG F+ DDE+++ ALAAAAG+AV+ Sbjct 134 SVGLPPNHPPMKTFLGVPVRVRDEVFGNLYMAEKRDGGDFTPDDEIVLSALAAAAGVAVE 193 Query 200 NARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDE 259 NARLFE+SR RE W+EA ++ ++L GA RLI++ L A A +L+ + + + Sbjct 194 NARLFEKSRMRERWLEAAAEVNAELLGGASAEDALRLISQRTRELAAAAVSLIVLAEEGK 253 Query 260 ----------APACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLD 309 A + D LV + GE + A + + V P F+RLD Sbjct 254 NGRRLLRMASAAGGDTDRLVGGLLDGENTFAHQVLDSGV-------------PALFERLD 300 Query 310 LAV-DGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRL 368 + + +E GP + +PLR A V GVL+A R F +Q+ ++A+FA QAA+A L Sbjct 301 GGLGEASLELGPGVAVPLRTASQVTGVLLAARDVGAAQFGAEQVPLLASFAAQAAVALEL 360 Query 369 ATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDD 428 A QR R V++L DRDRIARDLHDHVIQRLFA G++LQGA R P +RE + +++ Sbjct 361 AETQRNRRLVDVLEDRDRIARDLHDHVIQRLFATGMSLQGALNRVEDPKLRERVDNAVHQ 420 Query 429 LQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLA-IPALHTTVQYTGPL--SVVDTV 485 L + + EIR+ IFDL A GLR RL ++ Q+ AL V+ G + SV D V Sbjct 421 LDQTVLEIRTTIFDLQAADDE-PGLRRRLLDIVSQVTEHSALTPAVRMNGTVDNSVPDHV 479 Query 486 LANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQ 545 HAEAV+RE VSNAVRH+ A+ L + + + + + VVD+G+G+ + SGLRNL + Sbjct 480 -GEHAEAVVRELVSNAVRHSGASELTVTIEADRQLTISVVDNGIGMPEKVARSGLRNLDE 538 Query 546 RADDAGGEFTVENMPTGGTLLRWSAPL 572 RA GG VE GGT + W PL Sbjct 539 RARRLGGSAVVEACAGGGTRVTWQVPL 565 >gi|317507119|ref|ZP_07964880.1| GAF domain-containing protein [Segniliparus rugosus ATCC BAA-974] gi|316254613|gb|EFV13922.1| GAF domain-containing protein [Segniliparus rugosus ATCC BAA-974] Length=517 Score = 412 bits (1059), Expect = 8e-113, Method: Compositional matrix adjust. Identities = 257/529 (49%), Positives = 325/529 (62%), Gaps = 24/529 (4%) Query 49 LIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHL 108 LIDA+LAI+SGL L TLRAIV A LVD YGALGV D L EF+YEGIDE TR Sbjct 7 LIDAVLAISSGLDLSVTLRAIVQAAVGLVDCEYGALGVLREDGMLAEFIYEGIDEATRKQ 66 Query 109 IGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNL 168 IG LP GRGVLG +I++ KP+RL DI HPASVGFP HPPMR+FLGVP+ R VFG L Sbjct 67 IGDLPLGRGVLGVVIDDQKPLRLVDIKDHPASVGFPEGHPPMRSFLGVPIMARGMVFGRL 126 Query 169 YLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGA 228 YLTEK G F+D+DE LV ALAAAAG+AVDNARL+E+SR R W+EAT+++ +LA Sbjct 127 YLTEKRGGL-FTDEDERLVLALAAAAGVAVDNARLYEDSRRRRGWLEATKEVTEAILAET 185 Query 229 DPAMVFRLIAEEALTLMAG--AATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTV 286 V RL+AE A+ L AA LV+ P E + I G + + +M Sbjct 186 ARDEVLRLVAERAMGLAGSSFAAVLVSGP--------EGEPFGIAVREGRVPSGLSRM-- 235 Query 287 AVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEP--GPALVLPLRAADTVAGVLVALRSADE 344 + + D PRRF G P GP LV P+R L+ R D Sbjct 236 --DEPRLRDLAEDGAPRRF------APGEAAPGSGPVLVAPMRTGHVRLKTLLVARDPDA 287 Query 345 QPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGL 404 PF ++ + ++ +FA+QAA R A Q RE+E+L DR+RIARDLHDHVIQRLFA+GL Sbjct 288 APFEEEDVRLVGSFAEQAAFGLRWAAEQETRRELELLADRERIARDLHDHVIQRLFAIGL 347 Query 405 TLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQL 464 +Q A +PA+ + + ID L E+IQ+IR+ IF+L S A LR L ++ L Sbjct 348 GMQSTRRMAELPALADRLDDHIDKLHEVIQDIRATIFELQPDRSGAVRLRVALQNIVADL 407 Query 465 -AIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVE 523 A LH T + GPL V+ LA HAEAV+REAVSNAVRH+ + + + +SV D++ +E Sbjct 408 SADSGLHVTSRVAGPLGVLSAPLAQHAEAVVREAVSNAVRHSRGSEILVEMSVADELVIE 467 Query 524 VVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 V DDG+G+ DI SGL NL RA++AGG F+V GG L W APL Sbjct 468 VSDDGIGVPEDIDRSGLANLASRAEEAGGSFSVGPSELGGARLVWRAPL 516 >gi|183983462|ref|YP_001851753.1| two-component sensor histidine kinase [Mycobacterium marinum M] gi|183176788|gb|ACC41898.1| two-component sensor histidine kinase [Mycobacterium marinum M] Length=549 Score = 409 bits (1052), Expect = 6e-112, Method: Compositional matrix adjust. Identities = 236/543 (44%), Positives = 333/543 (62%), Gaps = 5/543 (0%) Query 35 RIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLV 94 ++++++ RD+++ L+ I+ I S L LDATLR IV A EL A YGAL VR + L+ Sbjct 4 QLDELLAARDQMEQLLRVIVEIGSDLDLDATLRRIVLAARELTSAPYGALAVRDPEGTLI 63 Query 95 EFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFL 154 F++ G+D++ IG LP G+GVLG + E +RLDD++ HPA+ GFP HHPPMR FL Sbjct 64 RFIHAGMDDDVARRIGHLPVGKGVLGVSLVETPALRLDDLTMHPAACGFPEHHPPMRAFL 123 Query 155 GVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWI 214 VP+ IR VFG+LYLT G+ FS+ DE +ALA AAG+A+DNA++FE RT W+ Sbjct 124 AVPITIRGTVFGSLYLTHVDPGRKFSESDEFAARALAFAAGVAIDNAQVFERERTAVKWM 183 Query 215 EATRDIGTQMLAGADPAMV-FRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEV 273 EA+R+I T +++ + +LIA+ A TL +V VP++ + E+D LV+ Sbjct 184 EASREITTALMSSTESRREPLQLIAQRACTLTDAEQAIVLVPVESDLATDEIDTLVVSAA 243 Query 274 AGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDG--PVEPGPALVLPLRAADT 331 G + V V V G++ G VF P + ++ V A+V+PL A + Sbjct 244 VGLHAEEVVGQQVPVRGSTCGDVFRSGEPLISEAFSYPIEAFTDVAQRSAIVMPLSAHEK 303 Query 332 VAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDL 391 VAGV+ R AD+ PF + LD+++ FA AA+A LA+ + R++ IL +R+RIA DL Sbjct 304 VAGVIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQLTILAERERIAHDL 363 Query 392 HDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRAT 451 HDHVIQRLFA G+ LQG RAR P V + + ++DDLQ II+EIRS IF L + R Sbjct 364 HDHVIQRLFASGMDLQGTLARARSPEVIDRLNRTVDDLQTIIEEIRSTIFQLKSPSGRDG 423 Query 452 GLRHRLDKVIDQLAIPA-LHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSL 510 G R R+ +V+ L + TT+ GP+S V LA+HAEAV EA+SNAVRH+ A + Sbjct 424 GFRQRIQQVVADLTEHRDVVTTIHMHGPMSAVQGELADHAEAVATEAISNAVRHSGAGRV 483 Query 511 AINVSVEDDVRVEVVDDGVGISGDIT-ESGLRNLRQRADDAGGEFTVENMPTGGTLLRWS 569 ++VSV D +EVVDDG GIS D++ SGL N+R RA+ GG + GGT + W+ Sbjct 484 TLDVSVGDMFSLEVVDDGCGISPDVSRRSGLANMRSRAEKLGGTCGITTPTEGGTRISWT 543 Query 570 APL 572 P Sbjct 544 VPF 546 >gi|296394120|ref|YP_003659004.1| GAF sensor signal transduction histidine kinase [Segniliparus rotundus DSM 44985] gi|296181267|gb|ADG98173.1| GAF sensor signal transduction histidine kinase [Segniliparus rotundus DSM 44985] Length=534 Score = 407 bits (1047), Expect = 2e-111, Method: Compositional matrix adjust. Identities = 249/525 (48%), Positives = 320/525 (61%), Gaps = 15/525 (2%) Query 49 LIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHL 108 LIDA+LA++SGL L ATLRAIV A LVD YGALGV D L EF+YEGIDE+TR Sbjct 23 LIDAVLAVSSGLDLPATLRAIVRAALGLVDCEYGALGVVREDGMLSEFIYEGIDEQTRKQ 82 Query 109 IGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNL 168 IG LP GRGVLGA+IE KP+ L DI HP SVGFP HPPMR+FLG P+ R VFG L Sbjct 83 IGDLPLGRGVLGAVIEGHKPLLLSDIKDHPNSVGFPEGHPPMRSFLGTPIIARGMVFGRL 142 Query 169 YLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGA 228 YLTEK G F+D+DE LV ALAAAAG+AVDNARL+E+SR R W+EAT+++ +LA Sbjct 143 YLTEKRGGGMFTDEDERLVLALAAAAGVAVDNARLYEDSRRRRGWLEATKEVTEAILAQT 202 Query 229 DPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAV 288 V RL+AE AL+LM + V V E + + G P + ++ A Sbjct 203 PRREVLRLVAERALSLMQCSFAAVLV------VESEAEPFGVAVRRGTAPPGLARLDEA- 255 Query 289 SGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVALRSADEQPFS 348 + + D RRF + A L+ P+R L+ R+ PF Sbjct 256 ---RLRAMAQDGKARRFGAGEAAPGAGP----VLIAPMRTGQVRLKALLVARAPGAVPFE 308 Query 349 DKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQG 408 +++L ++ +FA+QAA R + Q RE+E+L DR+RIARDLHDHVIQRLFA+GL +QG Sbjct 309 EEELRLLVSFAEQAAFGLRWSIQQEARRELELLADRERIARDLHDHVIQRLFAIGLGMQG 368 Query 409 AAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVIDQLAI-P 467 A P + + ID L E+IQ+IR+ IF+L S LR L ++ +++ Sbjct 369 TRRMALQPELPARLDDHIDRLHEVIQDIRATIFELQPDGSGVASLRATLQNILAEISRDS 428 Query 468 ALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDD 527 + T + +GPL VV LA HAEAV REAV+NAVRH T + + VSV D++ +EV DD Sbjct 429 GMRVTSRLSGPLGVVAAPLAQHAEAVAREAVTNAVRHCGGTEILVEVSVADELVIEVSDD 488 Query 528 GVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 GVGI+ I SGL+NL QRA++AGG F V P GG L W APL Sbjct 489 GVGIAQQIRRSGLKNLEQRANEAGGSFAVTASPLGGAKLVWRAPL 533 >gi|296171252|ref|ZP_06852656.1| GAF family protein [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894220|gb|EFG73977.1| GAF family protein [Mycobacterium parascrofulaceum ATCC BAA-614] Length=569 Score = 407 bits (1046), Expect = 3e-111, Method: Compositional matrix adjust. Identities = 229/556 (42%), Positives = 341/556 (62%), Gaps = 5/556 (0%) Query 23 LRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYG 82 LR + L+ + ++++++V R ++ L+ + I S L+LDA L IV A + ARYG Sbjct 12 LRQPDFLIRMHEQLDELVAERQQMGQLLQVAIEIGSDLELDAILHRIVAAAIGMTGARYG 71 Query 83 ALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVG 142 A+GV G + L FV+ G+D +T L+G LP G+GVLGAL + +P+RL ++ HP++VG Sbjct 72 AIGVWGPEGTLTSFVHSGMDPDTVALVGHLPVGKGVLGALRDRTEPLRLSRLTDHPSAVG 131 Query 143 FPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNAR 202 FP HHPPM+ FLG+PV IR V+G+LY+T+ G+ F + DE+ V+ALA+AA +A+DNAR Sbjct 132 FPEHHPPMQAFLGMPVIIRGAVYGSLYVTDDRPGRGFCEADEITVRALASAASVAIDNAR 191 Query 203 LFEESRTREAWIEATRDIGTQMLAGADPAM-VFRLIAEEALTLMAGAATLVAVPLDDEAP 261 LF+ R W +A+R+I T +L+ + P + +LIAE A L +V VP D + P Sbjct 192 LFDRVRAGARWTDASREISTALLSESYPDVRPLQLIAERAAELTDAEQAIVLVPADPDQP 251 Query 262 ACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPG-- 319 + EVD LV+ G + V V V G++ G VF P + + + G Sbjct 252 SDEVDRLVVSAAVGLHAKRVLGQEVPVRGSTSGEVFRSGRPLLTETFRRPIPAFTDVGER 311 Query 320 PALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVE 379 PA+++PL + GV+V R+ D PF ++ LD++ FAD AA+A LAT +R R++ Sbjct 312 PAILMPLTSDQHTLGVIVVARNTDASPFDEQHLDLVRDFADHAAIALTLATERRNARDLS 371 Query 380 ILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSA 439 +L DR+RIARDLHD VI R+F VG+ LQG R R P + + S+D+LQ +I++IR Sbjct 372 VLVDRERIARDLHDQVISRVFTVGMDLQGVLARLRSPELAARLTQSVDELQAVIEDIRRT 431 Query 440 IFDLHAGPSRATGLRHRLDKVIDQLAIPALH-TTVQYTGPLSVVDTVLANHAEAVLREAV 498 +FDL P+R L R+ I +L TT++ G ++ V LA HAEAV+REA+ Sbjct 432 VFDLQQPPARRRSLAERVQDAIARLTDDGNEGTTLRMAGTMTAVGDELAEHAEAVVREAL 491 Query 499 SNAVRHANATSLAINVSVEDDVRVEVVDDGVGIS-GDITESGLRNLRQRADDAGGEFTVE 557 NAVRH+ A ++A+ V+V D + +E+ DDG G++ G GL + +RA D GG+ + Sbjct 492 GNAVRHSRAATIAVEVTVTDQLLIEITDDGCGVAPGHRRRGGLDRIARRAKDLGGDCAIT 551 Query 558 NMPTGGTLLRWSAPLR 573 + P GGT +RWSAPLR Sbjct 552 SSPGGGTRVRWSAPLR 567 >gi|300787438|ref|YP_003767729.1| two-component system sensor kinase [Amycolatopsis mediterranei U32] gi|299796952|gb|ADJ47327.1| two-component system sensor kinase [Amycolatopsis mediterranei U32] Length=530 Score = 405 bits (1040), Expect = 1e-110, Method: Compositional matrix adjust. Identities = 252/540 (47%), Positives = 328/540 (61%), Gaps = 17/540 (3%) Query 37 EQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEF 96 E+ GRDR+D L A+LA ++GL+L+ TL IV AA LV ARYGAL + D R F Sbjct 3 EETTSGRDRMDALPAAVLAFSAGLELETTLDRIVTAAAGLVGARYGALALLDEDGRTTAF 62 Query 97 VYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGV 156 G+D+ TR +G P+G GVLG L+ P+RL H + G P HP M FLGV Sbjct 63 AVTGVDDATRERLGPPPDGHGVLGTLVTGRAPVRLA----HLGNGGLPPEHPSMGAFLGV 118 Query 157 PVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEA 216 P+ +R E+ G LYL+ + QPF+ DDE ALAAAAGIAVDNARL+EESR+R+ W+EA Sbjct 119 PLLVRGEILGRLYLSRE---QPFTTDDERATVALAAAAGIAVDNARLYEESRSRQRWLEA 175 Query 217 TRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGE 276 T +I ++L G D V LIA A L L+A P P LV+ AG Sbjct 176 TGEISAELLGGTDVREVLHLIATRAAELTGADDALIAWPESPGGP------LVVKVCAGP 229 Query 277 ISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRL--DLAVDGPVEPGPALVLPLRAADTVAG 334 + + + + G++ G V D PR L DLA V+ GPALV+ LR+ G Sbjct 230 DADVLAGRRIPLDGSTAGAVLRDHVPRSVPSLAFDLAAGLGVDLGPALVVRLRSGSRSGG 289 Query 335 -VLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHD 393 VL+A+R F + +L +++AFADQAALA R A +Q RE++++ DRDRIARDLHD Sbjct 290 AVLLAIRGRGAARFGEHELQLVSAFADQAALALRDAESQAARRELDVVVDRDRIARDLHD 349 Query 394 HVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGL 453 HVIQRLFAVGL ++G R+ PAV + ID LQ++I+EIRSAIF LHA P GL Sbjct 350 HVIQRLFAVGLGIEGTRRRSDSPAVTSRLIQHIDQLQDVIEEIRSAIFALHAQPGAGRGL 409 Query 454 RHRLDKVI-DQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAI 512 R RL I D A A+ TTV+ +G V LA HAEAV+REAV+N +RHA A LA+ Sbjct 410 RARLQNAITDGCADSAIRTTVRLSGAFDRVPAGLAEHAEAVVREAVTNVLRHARAADLAV 469 Query 513 NVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 VS++DD+ VEV D G+G+ + SGLRNL QRA +AGG ++ GGT L W+ P+ Sbjct 470 TVSLDDDLVVEVSDTGIGMPEAVARSGLRNLEQRAAEAGGSLRLDRPAGGGTCLVWTVPV 529 >gi|296169095|ref|ZP_06850754.1| GAF family protein [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295896215|gb|EFG75877.1| GAF family protein [Mycobacterium parascrofulaceum ATCC BAA-614] Length=574 Score = 404 bits (1039), Expect = 2e-110, Method: Compositional matrix adjust. Identities = 240/552 (44%), Positives = 343/552 (63%), Gaps = 6/552 (1%) Query 26 RELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALG 85 R L+ + +++++++ RD+++ L+ I+ I +GL L+ATL I+ A L A YGAL Sbjct 21 RGLVSRMHEQLDELLAARDQMEQLLRVIVEIGAGLDLNATLHRIIGAARRLTSAPYGALA 80 Query 86 VRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPL 145 +R D L+ FV+EG+D +T IG LP G+G+L + + +R+DD++ HPAS GFP Sbjct 81 IRDPDGNLLSFVHEGMDPDTVSRIGPLPVGKGLLSLSLLDTPALRMDDLTNHPASAGFPE 140 Query 146 HHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFE 205 HHPPMR FL VP+ IR+ VFGNLYLT + FS+ DEV +ALA AA +A+DNA++FE Sbjct 141 HHPPMRAFLAVPITIRETVFGNLYLTHVDPERVFSESDEVAARALAFAAAVAIDNAQVFE 200 Query 206 ESRTREAWIEATRDIGTQMLAGADPA-MVFRLIAEEALTLMAGAATLVAVPLDDEAPACE 264 RT W+EA+R+I T +L+ +P ++IAE A TL +V VP D + P E Sbjct 201 RERTAVKWMEASREITTALLSRPEPHRRPLQVIAESARTLTDAEQAIVLVPADPDLPDDE 260 Query 265 VDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPG--PAL 322 VD LV+ G + V V V ++ G VF P + L + + G PA+ Sbjct 261 VDTLVVSAAVGLHAAEVVGQRVPVDASTSGAVFRSGRPMITETLRYPIQAFTDVGQRPAI 320 Query 323 VLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILT 382 ++PLRA + V GV+ R ADE PF D LD+++ FA AA+A LA+A+ R + IL Sbjct 321 LMPLRAREEVVGVIAIARGADEPPFDDSYLDLVSDFATHAAIALVLASAREDARRLTILA 380 Query 383 DRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFD 442 +R+RIA DLHDHVIQRLFA G+ LQG RAR P V E + ++DDLQ II+EIR+ IF Sbjct 381 ERERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVAERLNRTLDDLQTIIEEIRTTIFQ 440 Query 443 LHAGPSRATGLRHRLDKVIDQLAIPA-LHTTVQYTGPLSVVDTVLANHAEAVLREAVSNA 501 L + PS + R+R+ +V+ L + TTV+ GP++ V LA+HAEAV EAVSN+ Sbjct 441 LKS-PSGKSDFRYRIQQVVADLTEDRDIVTTVRMHGPMTAVGGELADHAEAVTAEAVSNS 499 Query 502 VRHANATSLAINVSVEDDVRVEVVDDGVGI-SGDITESGLRNLRQRADDAGGEFTVENMP 560 +RH+ AT L + +SV D +++VD+G GI G+ SGL N+++RA+ GG + P Sbjct 500 LRHSGATRLTVEISVADMFVLDIVDNGSGIPDGNTRHSGLANMKRRAERLGGACEITGPP 559 Query 561 TGGTLLRWSAPL 572 GGT + W APL Sbjct 560 EGGTRVHWVAPL 571 >gi|72163445|ref|YP_291102.1| GAF:ATP-binding protein [Thermobifida fusca YX] gi|71917177|gb|AAZ57079.1| GAF:ATP-binding region, ATPase-like [Thermobifida fusca YX] Length=572 Score = 404 bits (1039), Expect = 2e-110, Method: Compositional matrix adjust. Identities = 244/559 (44%), Positives = 333/559 (60%), Gaps = 14/559 (2%) Query 22 QLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARY 81 Q+RL ELL E+Q RI ++ RDR+ L+DA+++I SGL L++TLR IV TA +LVDARY Sbjct 17 QMRLDELLSELQVRINAVMLVRDRVRSLLDAVVSIGSGLDLESTLRRIVSTAMDLVDARY 76 Query 82 GALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASV 141 GA+GV G L +F+ G+ +E + PEGRG+LG LI+EPK +RL IS HP S Sbjct 77 GAMGVIGPGGELEQFIPLGMSDEEIAAVEHWPEGRGLLGILIKEPKTLRLSCISEHPESA 136 Query 142 GFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNA 201 GFP HPPMRTFLGVP+R+R+EVFGNLYLTEK + F ++DE +V ALA AAGIA++NA Sbjct 137 GFPPGHPPMRTFLGVPIRVRNEVFGNLYLTEKRNNAVFDEEDEAIVTALATAAGIAIENA 196 Query 202 RLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAP 261 RL+EE+R RE W++A+ +I T++L+G P V L+A++A + +A P DE Sbjct 197 RLYEETRRRETWLDASDEITTRLLSGTAPREVLHLVAKKARHMADADLVAIATPDRDE-- 254 Query 262 ACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGP-----V 316 ++LV+ G + V+ + V G+ G F P + + P + Sbjct 255 ----EELVVRIADGPDASVVRGRSTPVEGSLTGRAFRGADPIITELARESATSPTLLHGL 310 Query 317 EPGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMR 376 + GP +++P A D+ GVL+ + A PF + M+ AFA AA+ LA A+R Sbjct 311 DIGPVVLVPFGAPDSRRGVLILGKRAGRLPFPMPTVQMLHAFAGHAAVTLELAEARRHAE 370 Query 377 EVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEI 436 + +L DRDRIA+DLHD VIQRLFA+ ++L + R V + I ++DDL + I++I Sbjct 371 RLIVLEDRDRIAKDLHDVVIQRLFAIAMSLMSSVRRIEDDTVAQRIQQAVDDLDDTIRQI 430 Query 437 RSAIFDL-HAGPSRATGLRHR-LDKVIDQLAIPALHTTVQYTGPL-SVVDTVLANHAEAV 493 RS IF L H LR R LD V V+ GP+ S V +A H AV Sbjct 431 RSTIFALQHNTEGGPAWLRSRILDVVGAATESLGFSPGVRLDGPIDSAVPDSIAEHVLAV 490 Query 494 LREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGE 553 LREA+SN RHA A+ I V V+ V + V DDGVG+ SGLRNL +RA+ GG Sbjct 491 LREALSNVARHARASQADIVVQVDSHVTLTVTDDGVGLPEQGRRSGLRNLAERAESLGGS 550 Query 554 FTVENMPTGGTLLRWSAPL 572 F P GGT+LRW PL Sbjct 551 FEAARRPEGGTMLRWQVPL 569 >gi|325001932|ref|ZP_08123044.1| GAF sensor signal transduction histidine kinase [Pseudonocardia sp. P1] Length=567 Score = 394 bits (1013), Expect = 2e-107, Method: Compositional matrix adjust. Identities = 258/578 (45%), Positives = 349/578 (61%), Gaps = 23/578 (3%) Query 5 DRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDA 64 D PG L LS LRL +L+ EVQDR+ +I R R+ L+DA+L + +GL+LDA Sbjct 2 DENASGPGE--LARLLSGLRLDQLIGEVQDRLGEIAGTRRRMQRLLDAVLGVAAGLELDA 59 Query 65 TLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIE 124 TL IV +A +LVDARYGALGV D + F+ G+D+ TR +G PEG+G+LG LIE Sbjct 60 TLERIVQSAVDLVDARYGALGVLAPDGSIARFIDVGLDDATRAALGRPPEGKGLLGQLIE 119 Query 125 EPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEK----ADGQPFS 180 +P+P+RLDD+S HPAS GFP +HPPM +FLGVP+R+R+ V+GN+YLTEK F+ Sbjct 120 DPRPLRLDDLSAHPASSGFPPNHPPMASFLGVPIRVREAVYGNIYLTEKIGPGGAAAGFT 179 Query 181 DDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADPAMVFRLIAEE 240 DDE+++QALAAAAGIAV NA LFE+ R+ W+EA+ +I ++LAG D L+A Sbjct 180 ADDELILQALAAAAGIAVQNADLFEQGLLRQQWLEASAEIRGEVLAGTDEPDTLALVARR 239 Query 241 ALTLMAGAATLVAV-PLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVSGTSIGGVFHD 299 L L +TL+A+ P DD+ E AG P + + GT + V Sbjct 240 CLELSRADSTLIALGPGDDDGGFRE------GATAGRAWP-----SGGLGGTLLRDVVEG 288 Query 300 RTPRRFDRLDLAVDGPVE---PGPALVLPLRAADTVAGVLVALRSADEQPFSDKQLDMMA 356 P D +D P + GP + +P+RA + V GVL+A R + + PF ++ ++ Sbjct 289 LQPVLADSPRAFLDSPADGGSAGPTVAVPMRAVERVIGVLIAQRRSGDPPFRPSEVPLLV 348 Query 357 AFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAVGLTLQGAAPRARVP 416 +FADQAALA L R +++ +L DRDRIARDLHDHVIQRLFAVGL LQG R Sbjct 349 SFADQAALALELGEKNRAQQQLAVLADRDRIARDLHDHVIQRLFAVGLKLQGTLRRTADG 408 Query 417 AVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHR-LDKVIDQLAIPALHTTVQY 475 RE + ++D+L ++EIR+ IFDL GLR R LD V + A L T+V Sbjct 409 PARERVEQAVDELDRTVREIRTTIFDLQTAEHGPGGLRRRLLDTVAEATAESGLTTSVHT 468 Query 476 TGPL-SVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGISGD 534 GP+ ++V +A H AV+REA +N VRHA A +L + V ++ E+VDDG GI G Sbjct 469 DGPVDTLVPATVATHLLAVVREAATNTVRHAAAHTLTVTVRAGRELGAEIVDDGRGIGGT 528 Query 535 ITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 SGLRNL +RA + G F + TGGT L W+ PL Sbjct 529 GRRSGLRNLEERAVELDGTFVADTPDTGGTRLVWTVPL 566 >gi|226361382|ref|YP_002779160.1| two-component histidine kinase [Rhodococcus opacus B4] gi|226239867|dbj|BAH50215.1| two-component histidine kinase [Rhodococcus opacus B4] Length=559 Score = 394 bits (1012), Expect = 2e-107, Method: Compositional matrix adjust. Identities = 230/546 (43%), Positives = 334/546 (62%), Gaps = 15/546 (2%) Query 31 EVQDRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYD 90 E ++ ++ +V R L L +A+L + SGL+LD+TL+ IV++A L+ ARYGALGV D Sbjct 24 EFREGLDAVVPTRRSLQRLFEAVLVVGSGLELDSTLQRIVNSATSLLGARYGALGVHAPD 83 Query 91 HRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPM 150 L EFVYEGI + R +G LPEGRG+LG L+ +P+P+RL +++ HP S+GFP +HPPM Sbjct 84 GGLSEFVYEGITPDERARMGHLPEGRGLLGLLVHDPRPVRLANLADHPGSIGFPPNHPPM 143 Query 151 RTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTR 210 ++FLG+P+ +R ++FG++YLTEK G F+D+DEV+++ALA +AG+AV+NARLFEESRTR Sbjct 144 KSFLGMPIMMRGKIFGSIYLTEKLSGPEFTDEDEVILRALATSAGVAVENARLFEESRTR 203 Query 211 EAWIEATRDIGTQMLAGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVI 270 E W+ A I ++++ G ++A E L +G + V L + A + Sbjct 204 ERWLTAVATITSRLMVGGSLDETLHMLAAEVRELSSGDEVFIVVTLGEGA---------V 254 Query 271 VEVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAAD 330 V + P + A V RTP +D G A VLPL A Sbjct 255 VGADSAMRPLRSTVRSATQAEPFAEVLRSRTPALLTGIDGLAPFSAAAGRAAVLPLSTAS 314 Query 331 TVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARD 390 V GVLV + + + ++ + + AD AA+A + Q + R + +L DRDRIARD Sbjct 315 GVGGVLV-VTARGTTAWDPDEVARLESVADLAAVAVEFSDQQSKQRLLSVLADRDRIARD 373 Query 391 LHDHVIQRLFAVGLTLQGAAPRARVP-AVRESIYSSIDDLQEIIQEIRSAIFDLHA-GPS 448 LHD+VIQRLFA G++LQ VP VR + ++++ L ++EIR+ IFDL A G + Sbjct 374 LHDNVIQRLFATGMSLQSTHAVGDVPDGVRSIVATAVEQLDRTVREIRTTIFDLQATGVA 433 Query 449 RATGLRHRLDKVIDQLAIPA-LHTTVQYTGPL-SVVDTVLANHAEAVLREAVSNAVRHAN 506 AT LR RL VI L + + VQ+TG + ++V + + HAEAVLREA+SNA+RHA Sbjct 434 SATSLRRRLLDVIGDLTSHSPVAPNVQFTGAIDTLVPSRIHPHAEAVLREALSNALRHAR 493 Query 507 ATSLAINVSVEDDVRVEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLL 566 AT++ I+V+ DD+ V V DDG+GI+ SGL NL +RA+ GG TV++ GGT++ Sbjct 494 ATTIDISVAAGDDLTVTVADDGIGIADGARRSGLDNLDRRAEHCGGTCTVDSA-DGGTVV 552 Query 567 RWSAPL 572 W PL Sbjct 553 TWRVPL 558 >gi|340528954|gb|AEK44159.1| two-component system sensor kinase [Amycolatopsis mediterranei S699] Length=519 Score = 394 bits (1012), Expect = 3e-107, Method: Compositional matrix adjust. Identities = 247/531 (47%), Positives = 322/531 (61%), Gaps = 17/531 (3%) Query 46 LDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEET 105 +D L A+LA ++GL+L+ TL IV AA LV ARYGAL + D R F G+D+ T Sbjct 1 MDALPAAVLAFSAGLELETTLDRIVTAAAGLVGARYGALALLDEDGRTTAFAVTGVDDAT 60 Query 106 RHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVRIRDEVF 165 R +G P+G GVLG L+ P+RL H + G P HP M FLGVP+ +R E+ Sbjct 61 RERLGPPPDGHGVLGTLVTGRAPVRLA----HLGNGGLPPEHPSMGAFLGVPLLVRGEIL 116 Query 166 GNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQML 225 G LYL+ + QPF+ DDE ALAAAAGIAVDNARL+EESR+R+ W+EAT +I ++L Sbjct 117 GRLYLSRE---QPFTTDDERATVALAAAAGIAVDNARLYEESRSRQRWLEATGEISAELL 173 Query 226 AGADPAMVFRLIAEEALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMT 285 G D V LIA A L L+A P P LV+ AG + + Sbjct 174 GGTDVREVLHLIATRAAELTGADDALIAWPESPGGP------LVVKVCAGPDADVLAGRR 227 Query 286 VAVSGTSIGGVFHDRTPRRFDRL--DLAVDGPVEPGPALVLPLRAADTVAG-VLVALRSA 342 + + G++ G V D PR L DLA V+ GPALV+ LR+ G VL+A+R Sbjct 228 IPLDGSTAGAVLRDHVPRSVPSLAFDLAAGLGVDLGPALVVRLRSGSRSGGAVLLAIRGR 287 Query 343 DEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIARDLHDHVIQRLFAV 402 F + +L +++AFADQAALA R A +Q RE++++ DRDRIARDLHDHVIQRLFAV Sbjct 288 GAARFGEHELQLVSAFADQAALALRDAESQAARRELDVVVDRDRIARDLHDHVIQRLFAV 347 Query 403 GLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSRATGLRHRLDKVI- 461 GL ++G R+ PAV + ID LQ++I+EIRSAIF LHA P GLR RL I Sbjct 348 GLGIEGTRRRSDSPAVTSRLIQHIDQLQDVIEEIRSAIFALHAQPGAGRGLRARLQNAIT 407 Query 462 DQLAIPALHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVR 521 D A A+ TTV+ +G V LA HAEAV+REAV+N +RHA A LA+ VS++DD+ Sbjct 408 DGCADSAIRTTVRLSGAFDRVPAGLAEHAEAVVREAVTNVLRHARAADLAVTVSLDDDLV 467 Query 522 VEVVDDGVGISGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLRWSAPL 572 VEV D G+G+ + SGLRNL QRA +AGG ++ GGT L W+ P+ Sbjct 468 VEVSDTGIGMPEAVARSGLRNLEQRAAEAGGSLRLDRPAGGGTCLVWTVPV 518 >gi|41409368|ref|NP_962204.1| hypothetical protein MAP3270c [Mycobacterium avium subsp. paratuberculosis K-10] gi|41398188|gb|AAS05818.1| hypothetical protein MAP_3270c [Mycobacterium avium subsp. paratuberculosis K-10] Length=551 Score = 390 bits (1003), Expect = 2e-106, Method: Compositional matrix adjust. Identities = 240/545 (45%), Positives = 330/545 (61%), Gaps = 6/545 (1%) Query 34 DRIEQIVEGRDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRL 93 +R +++ RD+ + L+ I I +GL LDATL I+ A EL A YGAL VR L Sbjct 4 NRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDRHANL 63 Query 94 VEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTF 153 + FV+EG+D ET IG P G+G+L + + +R+DD++ HPA+ GFP HHP MR F Sbjct 64 ISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAMRAF 123 Query 154 LGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESRTREAW 213 L VP+ IR VFGNLYLT + + FSD DE+ +ALA AA +A+DNA++FE R W Sbjct 124 LAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALAFAAAVAIDNAQVFERERMSVKW 183 Query 214 IEATRDIGTQMLAGADPA-MVFRLIAEEALTLMAGAATLVAVPLDDEAPAC-EVDDLVIV 271 IEA+R+I T +L+ +P +LIAE A L +V VP D E P EVD LV++ Sbjct 184 IEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTLVVL 243 Query 272 EVAGEISPAVKQMTVAVSGTSIGGVFHDRTPRRFDRLDLAVDGPVEPG--PALVLPLRAA 329 G + V V V G++ G VF P D + + G PA+V+PLRA Sbjct 244 AAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRAR 303 Query 330 DTVAGVLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIAR 389 D V GV+ R ++ PF + LD++ FA AA+A LA A+ R++ +L +R+RIA Sbjct 304 DEVVGVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERERIAH 363 Query 390 DLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQEIRSAIFDLHAGPSR 449 DLHDHVIQRLFA G+ LQG RAR P V + + ++DDLQ II+EIR+ IF L + + Sbjct 364 DLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEIRTTIFALRSPAAV 423 Query 450 ATGLRHRLDKVIDQLAIPA-LHTTVQYTGPLSVVDTVLANHAEAVLREAVSNAVRHANAT 508 A RHR+ +VI +L L TTV+ GP++ V LA HAEAV EAVSNAVRH+ A+ Sbjct 424 AGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHSGAS 483 Query 509 SLAINVSVEDDVRVEVVDDGVGI-SGDITESGLRNLRQRADDAGGEFTVENMPTGGTLLR 567 L + + V D ++V+D+G GI SG+ SGL N+ +RA+ GG + + P GGT + Sbjct 484 RLTVQIGVADMFTLDVIDNGRGIASGNTRRSGLANMTRRAEQLGGSCEISSPPGGGTRVH 543 Query 568 WSAPL 572 W+APL Sbjct 544 WTAPL 548 Lambda K H 0.320 0.136 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1288955502984 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40