BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2066 Length=508 Score E Sequences producing significant alignments: (Bits) Value gi|15609203|ref|NP_216582.1| bifunctional S-adenosyl-L-methionin... 1008 0.0 gi|340627077|ref|YP_004745529.1| putative bifunctional protein, ... 995 0.0 gi|289750660|ref|ZP_06510038.1| bifunctional cobI-cobJ fusion pr... 908 0.0 gi|254819624|ref|ZP_05224625.1| CobI [Mycobacterium intracellula... 805 0.0 gi|183983047|ref|YP_001851338.1| bifunctional protein: CobI-CobJ... 802 0.0 gi|240172454|ref|ZP_04751113.1| bifunctional protein, CobI-CobJ ... 802 0.0 gi|289762223|ref|ZP_06521601.1| cobalamin biosynthesis protein c... 799 0.0 gi|296165158|ref|ZP_06847707.1| precorrin-3B C(17)-methyltransfe... 798 0.0 gi|118617807|ref|YP_906139.1| bifunctional protein, CobI-CobJ fu... 797 0.0 gi|342859783|ref|ZP_08716436.1| CobI [Mycobacterium colombiense ... 793 0.0 gi|254775095|ref|ZP_05216611.1| cobalamin biosynthesis protein c... 787 0.0 gi|41407910|ref|NP_960746.1| CobI [Mycobacterium avium subsp. pa... 783 0.0 gi|118463444|ref|YP_881626.1| cobalamin biosynthesis protein cob... 779 0.0 gi|118470330|ref|YP_888164.1| cobalamin biosynthesis protein cob... 776 0.0 gi|126435108|ref|YP_001070799.1| precorrin-3 methyltransferase /... 766 0.0 gi|108799454|ref|YP_639651.1| precorrin-3 methyltransferase / pr... 764 0.0 gi|120404403|ref|YP_954232.1| precorrin-3B C17-methyltransferase... 749 0.0 gi|315444018|ref|YP_004076897.1| precorrin-2 C20-methyltransfera... 746 0.0 gi|145223691|ref|YP_001134369.1| precorrin-3B C17-methyltransfer... 745 0.0 gi|169629284|ref|YP_001702933.1| cobalamin biosynthesis protein ... 676 0.0 gi|226359708|ref|YP_002777486.1| precorrin-2 C(20)-methyltransfe... 609 4e-172 gi|312139748|ref|YP_004007084.1| s-adenosyl-l-methionine-precorr... 608 5e-172 gi|325676800|ref|ZP_08156473.1| bifunctional S-adenosyl-L-methio... 607 1e-171 gi|111017196|ref|YP_700168.1| bifunctional S-adenosyl-L-methioni... 597 2e-168 gi|226306631|ref|YP_002766591.1| precorrin-2 C(20)-methyltransfe... 596 3e-168 gi|305407948|dbj|BAJ15905.1| S-adenosyl-L-methionine-precorrin-2... 595 6e-168 gi|229493684|ref|ZP_04387469.1| cobalamin biosynthesis protein c... 593 2e-167 gi|134102398|ref|YP_001108059.1| precorrin-3B C17-methyltransfer... 591 9e-167 gi|291004217|ref|ZP_06562190.1| precorrin-3B C17-methyltransfera... 590 1e-166 gi|54025121|ref|YP_119363.1| putative precorrin 2 methyltransfer... 589 4e-166 gi|296270460|ref|YP_003653092.1| precorrin-3B C17-methyltransfer... 572 5e-161 gi|302554740|ref|ZP_07307082.1| precorrin-3B C17-methyltransfera... 571 9e-161 gi|284032968|ref|YP_003382899.1| precorrin-3B C17-methyltransfer... 569 5e-160 gi|290955548|ref|YP_003486730.1| bifunctional protein S-adenosyl... 566 4e-159 gi|182437615|ref|YP_001825334.1| putative precorrin methylase [S... 565 7e-159 gi|345011368|ref|YP_004813722.1| precorrin-3B C17-methyltransfer... 564 1e-158 gi|326778269|ref|ZP_08237534.1| precorrin-3B C17-methyltransfera... 563 2e-158 gi|345000992|ref|YP_004803846.1| precorrin-3B C17-methyltransfer... 563 2e-158 gi|320009606|gb|ADW04456.1| precorrin-3B C17-methyltransferase [... 561 9e-158 gi|302529244|ref|ZP_07281586.1| precorrin-2 C20-methyltransferas... 560 3e-157 gi|333919703|ref|YP_004493284.1| Precorrin-3B C17-methyltransfer... 559 5e-157 gi|300788890|ref|YP_003769181.1| precorrin-2 C20-methyltransfera... 558 1e-156 gi|308403445|ref|ZP_07493819.2| precorrin-2 C(20)-methyltransfer... 552 4e-155 gi|256375915|ref|YP_003099575.1| precorrin-3B C17-methyltransfer... 551 1e-154 gi|239989004|ref|ZP_04709668.1| putative precorrin methylase [St... 548 1e-153 gi|271966894|ref|YP_003341090.1| precorrin-3B methylase-like pro... 548 1e-153 gi|318059041|ref|ZP_07977764.1| bifunctional protein S-adenosyl-... 546 3e-153 gi|294813428|ref|ZP_06772071.1| putative precorrin methylase [St... 542 5e-152 gi|297155176|gb|ADI04888.1| bifunctional protein S-adenosyl-L-me... 542 6e-152 gi|302523275|ref|ZP_07275617.1| precorrin-3B C17-methyltransfera... 542 6e-152 >gi|15609203|ref|NP_216582.1| bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J [Mycobacterium tuberculosis H37Rv] gi|15841555|ref|NP_336592.1| S-adenosyl-L-methionine--precorrin-2 methyltransferase/precorrin-3b c17-methyltransferase [Mycobacterium tuberculosis CDC1551] gi|31793249|ref|NP_855742.1| bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J [Mycobacterium bovis AF2122/97] 74 more sequence titles Length=508 Score = 1008 bits (2606), Expect = 0.0, Method: Compositional matrix adjust. Identities = 508/508 (100%), Positives = 508/508 (100%), Gaps = 0/508 (0%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE Sbjct 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV Sbjct 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR Sbjct 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT Sbjct 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV Sbjct 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 Query 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE Sbjct 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 Query 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV Sbjct 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 Query 481 DSQDRVFTPRRYPEAGRATATKSSRHSD 508 DSQDRVFTPRRYPEAGRATATKSSRHSD Sbjct 481 DSQDRVFTPRRYPEAGRATATKSSRHSD 508 >gi|340627077|ref|YP_004745529.1| putative bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase [Mycobacterium canettii CIPT 140010059] gi|340005267|emb|CCC44421.1| putative bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase [Mycobacterium canettii CIPT 140010059] Length=508 Score = 995 bits (2573), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/508 (99%), Positives = 502/508 (99%), Gaps = 0/508 (0%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE Sbjct 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE TNHPGGYAGALEDFY +ATERIA HLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLVYPVTTETTNHPGGYAGALEDFYTEATERIAAHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV Sbjct 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDET VPYFSLAMLPGGR Sbjct 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETGVPYFSLAMLPGGR 240 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 RRA LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT Sbjct 241 RRASLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV Sbjct 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 Query 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPAS TRTWQVGAMRE Sbjct 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASATRTWQVGAMRE 420 Query 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV Sbjct 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 Query 481 DSQDRVFTPRRYPEAGRATATKSSRHSD 508 DSQDRVFTPRRYPEAGRATATKSSRHSD Sbjct 481 DSQDRVFTPRRYPEAGRATATKSSRHSD 508 >gi|289750660|ref|ZP_06510038.1| bifunctional cobI-cobJ fusion protein [Mycobacterium tuberculosis T92] gi|289691247|gb|EFD58676.1| bifunctional cobI-cobJ fusion protein [Mycobacterium tuberculosis T92] Length=490 Score = 908 bits (2347), Expect = 0.0, Method: Compositional matrix adjust. Identities = 490/508 (97%), Positives = 490/508 (97%), Gaps = 18/508 (3%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE Sbjct 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV Sbjct 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR Sbjct 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 RRALLTGTVAVVGLGPGDSDWMTPQSRR EVRDGQRRHPSDNT Sbjct 241 RRALLTGTVAVVGLGPGDSDWMTPQSRR------------------EVRDGQRRHPSDNT 282 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV Sbjct 283 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 342 Query 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE Sbjct 343 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 402 Query 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV Sbjct 403 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 462 Query 481 DSQDRVFTPRRYPEAGRATATKSSRHSD 508 DSQDRVFTPRRYPEAGRATATKSSRHSD Sbjct 463 DSQDRVFTPRRYPEAGRATATKSSRHSD 490 >gi|254819624|ref|ZP_05224625.1| CobI [Mycobacterium intracellulare ATCC 13950] Length=497 Score = 805 bits (2078), Expect = 0.0, Method: Compositional matrix adjust. Identities = 434/499 (87%), Positives = 463/499 (93%), Gaps = 11/499 (2%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M+ARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAE YLRPGQ+E Sbjct 1 MTARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAERYLRPGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE T+HPGGYAGALEDFYA+ATERIA HLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLVYPVTTEVTDHPGGYAGALEDFYAEATERIAAHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLADADAAV Sbjct 121 HTRLTERFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVAELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 V+KLGRSYH VREALSASG L D FYVERAS+AGQR+LPAA+VDETSVPYFSLAMLPGGR Sbjct 181 VLKLGRSYHAVREALSASGQLDDTFYVERASSAGQRILPAAEVDETSVPYFSLAMLPGGR 240 Query 241 R------RALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRR 294 R TG+VAVVGLGPGD+DWMTPQSRRELAAATDLIGY GYLDRV V +GQ+R Sbjct 241 RLHRRAPEGQATGSVAVVGLGPGDADWMTPQSRRELAAATDLIGYGGYLDRVPVHEGQQR 300 Query 295 HPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAM 354 HPSDN DEP RARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV++RVIPAM Sbjct 301 HPSDNRDEPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVQIRVIPAM 360 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAAQAVASRVGAPLGHDYAVISLSDRLKPW+VI+ARL AAAAADLVLAIYNPAS TRTWQ Sbjct 361 TAAQAVASRVGAPLGHDYAVISLSDRLKPWEVISARLEAAAAADLVLAIYNPASKTRTWQ 420 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 VGAMR++LLAHR+PG PVVIGRN VSG +EDVRVV+LADLNPAEIDMRCLLIVGSSQ Sbjct 421 VGAMRDILLAHREPGTPVVIGRN----VSGDDEDVRVVRLADLNPAEIDMRCLLIVGSSQ 476 Query 475 TRWYSVDS-QDRVFTPRRY 492 T+WYS DS +DRVFTPRRY Sbjct 477 TQWYSADSAEDRVFTPRRY 495 >gi|183983047|ref|YP_001851338.1| bifunctional protein: CobI-CobJ fusion protein [Mycobacterium marinum M] gi|183176373|gb|ACC41483.1| bifunctional protein: CobI-CobJ fusion protein [Mycobacterium marinum M] Length=489 Score = 802 bits (2072), Expect = 0.0, Method: Compositional matrix adjust. Identities = 437/493 (89%), Positives = 460/493 (94%), Gaps = 4/493 (0%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M+ RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAE YLRPGQ+E Sbjct 1 MTDRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAERYLRPGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHL+YPVTTE T+HPGGYAGALEDFY ATERIATHLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLIYPVTTETTDHPGGYAGALEDFYEQATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT+RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLAD DAAV Sbjct 121 HTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVAELTRRLADVDAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 V+KLGRSYHNVREALSASG L D FYVERAST GQRVLPAADVDE SVPYFSLAMLPGGR Sbjct 181 VLKLGRSYHNVREALSASGQLDDTFYVERASTPGQRVLPAADVDEASVPYFSLAMLPGGR 240 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 R ++ GTVAVVGLGPGD+DWMTPQSRRELA ATDLIGY YLDR+ VRDGQRRHPSDNT Sbjct 241 RSTVVAGTVAVVGLGPGDTDWMTPQSRRELARATDLIGYGPYLDRISVRDGQRRHPSDNT 300 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 DEPARARLACSLA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV VRVIPAMTAAQAV Sbjct 301 DEPARARLACSLAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVPVRVIPAMTAAQAV 360 Query 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 ASRVGAPLGHDYAVISLSDRLKPW+VIAARL AAAAADLVLAIYNPAS TRTWQVGAMRE Sbjct 361 ASRVGAPLGHDYAVISLSDRLKPWEVIAARLGAAAAADLVLAIYNPASKTRTWQVGAMRE 420 Query 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 LLL HRDPG PVVIG N VSGP+E VRVV+LADLNPA++DMRCLLI+GSSQT+WY+V Sbjct 421 LLLQHRDPGTPVVIGHN----VSGPDEAVRVVRLADLNPADVDMRCLLIIGSSQTQWYAV 476 Query 481 DSQDRVFTPRRYP 493 DS DRVFTPRRYP Sbjct 477 DSTDRVFTPRRYP 489 >gi|240172454|ref|ZP_04751113.1| bifunctional protein, CobI-CobJ fusion protein [Mycobacterium kansasii ATCC 12478] Length=490 Score = 802 bits (2071), Expect = 0.0, Method: Compositional matrix adjust. Identities = 436/493 (89%), Positives = 459/493 (94%), Gaps = 4/493 (0%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M+ RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLR GQ+E Sbjct 1 MTRRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRAGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE T HPGGYAGALEDFY ATERIA HLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLVYPVTTETTGHPGGYAGALEDFYVQATERIAAHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLTRRFNAVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLADADAAV Sbjct 121 HTRLTRRFNAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVAELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 V+KLGRSYH VREALSASG L D FYVERASTAGQRVLPAADVDE +VPYFSLAMLPGGR Sbjct 181 VLKLGRSYHTVREALSASGQLDDTFYVERASTAGQRVLPAADVDEATVPYFSLAMLPGGR 240 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 RRA + G+VAVVGLGPGD DWMTPQSRRELA ATDLIGY YL+R+ VRDGQRRHPSDNT Sbjct 241 RRASVVGSVAVVGLGPGDMDWMTPQSRRELACATDLIGYHTYLNRIPVRDGQRRHPSDNT 300 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 DEPARARLACSLA+QG+AVAVVSSGDPGVFAMATAVLEEA+QWP V++RVIPAMTAAQAV Sbjct 301 DEPARARLACSLAEQGQAVAVVSSGDPGVFAMATAVLEEAKQWPDVQIRVIPAMTAAQAV 360 Query 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPAS TR WQVGAMR+ Sbjct 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASKTRIWQVGAMRD 420 Query 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 LLL HR+PG PVV+GR+ VSGP EDVRVV+LADLNPA+IDMRCLLI+GSSQT+WYS Sbjct 421 LLLEHREPGTPVVVGRD----VSGPEEDVRVVRLADLNPADIDMRCLLIIGSSQTQWYST 476 Query 481 DSQDRVFTPRRYP 493 DS DRVFTPRRYP Sbjct 477 DSGDRVFTPRRYP 489 >gi|289762223|ref|ZP_06521601.1| cobalamin biosynthesis protein cobIJ [Mycobacterium tuberculosis GM 1503] gi|289709729|gb|EFD73745.1| cobalamin biosynthesis protein cobIJ [Mycobacterium tuberculosis GM 1503] Length=406 Score = 799 bits (2064), Expect = 0.0, Method: Compositional matrix adjust. Identities = 405/406 (99%), Positives = 406/406 (100%), Gaps = 0/406 (0%) Query 103 VALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPG 162 +ALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPG Sbjct 1 MALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPG 60 Query 163 TLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAAD 222 TLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAAD Sbjct 61 TLPVGELTRRLADADAAVVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAAD 120 Query 223 VDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGY 282 VDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGY Sbjct 121 VDETSVPYFSLAMLPGGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGY 180 Query 283 LDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ 342 LDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ Sbjct 181 LDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ 240 Query 343 WPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLA 402 WPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLA Sbjct 241 WPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLA 300 Query 403 IYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEI 462 IYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEI Sbjct 301 IYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEI 360 Query 463 DMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD 508 DMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD Sbjct 361 DMRCLLIVGSSQTRWYSVDSQDRVFTPRRYPEAGRATATKSSRHSD 406 >gi|296165158|ref|ZP_06847707.1| precorrin-3B C(17)-methyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295899502|gb|EFG78959.1| precorrin-3B C(17)-methyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=493 Score = 798 bits (2061), Expect = 0.0, Method: Compositional matrix adjust. Identities = 425/495 (86%), Positives = 459/495 (93%), Gaps = 6/495 (1%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M+ARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLRPGQLE Sbjct 1 MTARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQLE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHL+YPVTTE T+HPGGYAGALEDFY +A RIA HLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLIYPVTTEVTDHPGGYAGALEDFYVEAAARIAAHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT+RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLADADAAV Sbjct 121 HTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVAELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 V+KLGRSYH VREALSASG L D +YVERAST+GQR+LPAADVDE VPYFSLAMLPGGR Sbjct 181 VLKLGRSYHAVREALSASGQLDDTYYVERASTSGQRILPAADVDEAGVPYFSLAMLPGGR 240 Query 241 --RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSD 298 R++ G+VAVVGLGPGDSDWMTPQSRRELAAATDLIGY GYLDRV VRDGQRRHPSD Sbjct 241 RGRQSPPAGSVAVVGLGPGDSDWMTPQSRRELAAATDLIGYGGYLDRVPVRDGQRRHPSD 300 Query 299 NTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQ 358 NTDEP RARLAC+LA++GRAVAVVSSGDPGVFAMATAVLEEA++WP VRVRVIPAMTAAQ Sbjct 301 NTDEPERARLACALAEEGRAVAVVSSGDPGVFAMATAVLEEAKEWPAVRVRVIPAMTAAQ 360 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 AVASRVGAPLGHDYAVISLSDRLKPW++I+ RL AAAAADLVLAIYNPAS TRTWQV AM Sbjct 361 AVASRVGAPLGHDYAVISLSDRLKPWEIISERLAAAAAADLVLAIYNPASRTRTWQVAAM 420 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+LLL HR+PG PVV+GR+ V+GP+EDVRVV+LADL+PA +DMRCLLIVGSSQT+WY Sbjct 421 RDLLLQHREPGTPVVVGRS----VAGPDEDVRVVRLADLDPATVDMRCLLIVGSSQTQWY 476 Query 479 SVDSQDRVFTPRRYP 493 + DS DRVFTPRRYP Sbjct 477 AGDSGDRVFTPRRYP 491 >gi|118617807|ref|YP_906139.1| bifunctional protein, CobI-CobJ fusion protein [Mycobacterium ulcerans Agy99] gi|118569917|gb|ABL04668.1| bifunctional protein, CobI-CobJ fusion protein [Mycobacterium ulcerans Agy99] Length=489 Score = 797 bits (2058), Expect = 0.0, Method: Compositional matrix adjust. Identities = 434/493 (89%), Positives = 458/493 (93%), Gaps = 4/493 (0%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M+ RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAE YLRPGQ+E Sbjct 1 MTDRGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAERYLRPGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHL+YPVTTE T+HPGGYAGALEDFY ATERIA HLDAGRNVALLAEGDPLFYSSY+HL Sbjct 61 EHLIYPVTTETTDHPGGYAGALEDFYEQATERIAAHLDAGRNVALLAEGDPLFYSSYVHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT+RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLAD DAAV Sbjct 121 HTRLTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVAELTRRLADVDAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 V+KLGRSYHNVREALS SG L D FYVERAST GQRVLPAADVDE SVPYFSLAMLPGGR Sbjct 181 VLKLGRSYHNVREALSTSGQLDDTFYVERASTPGQRVLPAADVDEASVPYFSLAMLPGGR 240 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 R ++ GTVAVVGLGPGD+DWMTPQSRRELA ATDLIGY YLDR+ VRDGQRRHPSDNT Sbjct 241 RSTVVAGTVAVVGLGPGDTDWMTPQSRRELARATDLIGYGPYLDRISVRDGQRRHPSDNT 300 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAV 360 DEPARARLACSLA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV VRVIPAMTAAQAV Sbjct 301 DEPARARLACSLAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVPVRVIPAMTAAQAV 360 Query 361 ASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRE 420 ASRVGAPLGHDYAVISLSDRLKPW+VIAARL AAAAADLVLAIYNPAS TR WQVGAMRE Sbjct 361 ASRVGAPLGHDYAVISLSDRLKPWEVIAARLGAAAAADLVLAIYNPASKTRAWQVGAMRE 420 Query 421 LLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSV 480 LLL HRDPG PVVIGRN VSGP+EDVRVV+LADLNPA++DMRCLLI+GSSQT+WY+V Sbjct 421 LLLQHRDPGTPVVIGRN----VSGPDEDVRVVRLADLNPADVDMRCLLIIGSSQTQWYAV 476 Query 481 DSQDRVFTPRRYP 493 DS DRVFTPR YP Sbjct 477 DSTDRVFTPRHYP 489 >gi|342859783|ref|ZP_08716436.1| CobI [Mycobacterium colombiense CECT 3035] gi|342132915|gb|EGT86135.1| CobI [Mycobacterium colombiense CECT 3035] Length=492 Score = 793 bits (2047), Expect = 0.0, Method: Compositional matrix adjust. Identities = 426/494 (87%), Positives = 456/494 (93%), Gaps = 6/494 (1%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M+ARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLRPGQ+E Sbjct 1 MTARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE T+HPGGYAGA+EDFY +ATERIA HLDAGRNVALLAEGDPLFYSSYMHL Sbjct 61 EHLVYPVTTETTDHPGGYAGAIEDFYVEATERIAGHLDAGRNVALLAEGDPLFYSSYMHL 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLP ELTRRLADADAAV Sbjct 121 HTRLTERFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPAEELTRRLADADAAV 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 V+KLGRSYH VREALSASG L DAFYVERASTA QR+LPAADVDE VPYFSLA+LPGG+ Sbjct 181 VLKLGRSYHAVREALSASGRLDDAFYVERASTAAQRILPAADVDEAGVPYFSLAILPGGQ 240 Query 241 RR--ALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSD 298 R TG+V VVGLGPGD DWMTPQ+RRELAAA+DLIGY GYLDRV RDGQRRHPSD Sbjct 241 RGRPEPATGSVTVVGLGPGDVDWMTPQTRRELAAASDLIGYGGYLDRVPARDGQRRHPSD 300 Query 299 NTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQ 358 N DEP RARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA++WPGV+VRVIPAMTAAQ Sbjct 301 NRDEPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKEWPGVQVRVIPAMTAAQ 360 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 AVASRVGAPLGHDYAVISLSDRLKPW+VI+ARL AAAAADLVLA+YNPAS TRTWQVG M Sbjct 361 AVASRVGAPLGHDYAVISLSDRLKPWEVISARLRAAAAADLVLAVYNPASKTRTWQVGEM 420 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R++LLAHR+PG PVVIGRN VSGP+EDVRVV+LADL+P EIDMRCLLIVGSSQT+WY Sbjct 421 RDILLAHREPGTPVVIGRN----VSGPDEDVRVVRLADLDPGEIDMRCLLIVGSSQTQWY 476 Query 479 SVDSQDRVFTPRRY 492 S DS DRVFTPRRY Sbjct 477 SHDSTDRVFTPRRY 490 >gi|254775095|ref|ZP_05216611.1| cobalamin biosynthesis protein cobIJ [Mycobacterium avium subsp. avium ATCC 25291] Length=496 Score = 787 bits (2032), Expect = 0.0, Method: Compositional matrix adjust. Identities = 420/491 (86%), Positives = 451/491 (92%), Gaps = 6/491 (1%) Query 4 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHL 63 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLRPGQ+EEHL Sbjct 8 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIEEHL 67 Query 64 VYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTR 123 VYPVTTE T+HPGGYAGA+EDFY +AT RIA HLDAGR+VALLAEGDPLFYSSYMHLHTR Sbjct 68 VYPVTTEVTDHPGGYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSSYMHLHTR 127 Query 124 LTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVK 183 LT+RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLADADAAVV+K Sbjct 128 LTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVAELTRRLADADAAVVLK 187 Query 184 LGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR--R 241 LGRSYH VREALS SG L DA YVERAST+ QR++PAADVD VPYF+LA+LPGG+ R Sbjct 188 LGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDADGVPYFALAILPGGQRAR 247 Query 242 RALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTD 301 RA GTV VVGLGPGD+ WMTPQSRRELAAATDL+GY YLDRV VR GQRRHPSDN D Sbjct 248 RAPSAGTVVVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRGGQRRHPSDNRD 307 Query 302 EPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVA 361 EP RARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV+VRVIPAMTAAQAVA Sbjct 308 EPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVQVRVIPAMTAAQAVA 367 Query 362 SRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMREL 421 SRVGAPLGHDYAVISLSDRLKPW+VIAARL AAA ADLVLAIYNPAS TRTWQVGAMR++ Sbjct 368 SRVGAPLGHDYAVISLSDRLKPWEVIAARLEAAATADLVLAIYNPASKTRTWQVGAMRDI 427 Query 422 LLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVD 481 LLA R+PG PVVIGR+ VSGP+EDVRVV+LADL+PAEIDMRCLLIVGSSQT+WYS D Sbjct 428 LLARREPGTPVVIGRD----VSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWYSDD 483 Query 482 SQDRVFTPRRY 492 S DRVFTPRRY Sbjct 484 SGDRVFTPRRY 494 >gi|41407910|ref|NP_960746.1| CobI [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396264|gb|AAS04129.1| CobI [Mycobacterium avium subsp. paratuberculosis K-10] gi|336462049|gb|EGO40895.1| precorrin-2 C20-methyltransferase [Mycobacterium avium subsp. paratuberculosis S397] Length=496 Score = 783 bits (2023), Expect = 0.0, Method: Compositional matrix adjust. Identities = 425/491 (87%), Positives = 454/491 (93%), Gaps = 6/491 (1%) Query 4 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHL 63 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLRPGQ+EEHL Sbjct 8 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIEEHL 67 Query 64 VYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTR 123 VYPVTTE T+HPGGYAGA+EDFY +AT RIA HLDAGR+VALLAEGDPLFYSSYMHLHTR Sbjct 68 VYPVTTEVTDHPGGYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSSYMHLHTR 127 Query 124 LTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVK 183 LT+RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLADADAAVV+K Sbjct 128 LTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVSELTRRLADADAAVVLK 187 Query 184 LGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR--R 241 LGRSYH VREALS SG L DA YVERAST+ QR++PAADVD VPYFSLA+LPGG+ R Sbjct 188 LGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDAAGVPYFSLAILPGGQRAR 247 Query 242 RALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTD 301 RA GTVAVVGLGPGD+ WMTPQSRRELAAATDL+GY YLDRV VRDGQRRHPSDN D Sbjct 248 RAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRRHPSDNRD 307 Query 302 EPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVA 361 EP RARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGVRVRVIPAMTAAQAVA Sbjct 308 EPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVRVRVIPAMTAAQAVA 367 Query 362 SRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMREL 421 SRVGAPLGHDYAVISLSDRLKPW+VIAARL AAAAADLVLAIYNPAS TRTWQVGAMR++ Sbjct 368 SRVGAPLGHDYAVISLSDRLKPWEVIAARLEAAAAADLVLAIYNPASKTRTWQVGAMRDI 427 Query 422 LLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVD 481 LLA R+PG PVVIGR+ VSGP+EDVRVV+LADL+PAEIDMRCLLIVGSSQT+WYS D Sbjct 428 LLARREPGTPVVIGRD----VSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWYSDD 483 Query 482 SQDRVFTPRRY 492 S DRVFTPRRY Sbjct 484 SADRVFTPRRY 494 >gi|118463444|ref|YP_881626.1| cobalamin biosynthesis protein cobIJ [Mycobacterium avium 104] gi|118164731|gb|ABK65628.1| cobalamin biosynthesis protein cobIJ [Mycobacterium avium 104] Length=496 Score = 779 bits (2012), Expect = 0.0, Method: Compositional matrix adjust. Identities = 423/491 (87%), Positives = 453/491 (93%), Gaps = 6/491 (1%) Query 4 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHL 63 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLRPGQ+EEHL Sbjct 8 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGRSIARGIAEPYLRPGQIEEHL 67 Query 64 VYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTR 123 VYPVTTE T+HPGGYAGA+EDFY +AT RIA HLDAGR+VALLAEGDPLFYSSYMHLHTR Sbjct 68 VYPVTTEVTDHPGGYAGAIEDFYVEATARIAAHLDAGRDVALLAEGDPLFYSSYMHLHTR 127 Query 124 LTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVK 183 LT+RF+AVIVPGVTSVSAASAA+ATPLVAGD+VLSVLPGTLPV ELTRRLADADAAVV+K Sbjct 128 LTQRFDAVIVPGVTSVSAASAAIATPLVAGDEVLSVLPGTLPVTELTRRLADADAAVVLK 187 Query 184 LGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR--R 241 LGRSYH VREALS SG L DA YVERAST+ QR++PAADVD VPYFSLA+LPGG+ R Sbjct 188 LGRSYHAVREALSQSGQLDDAVYVERASTSAQRIVPAADVDADGVPYFSLAILPGGQRAR 247 Query 242 RALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTD 301 RA GTVAVVGLGPGD+ WMTPQSRRELAAATDL+GY YLDRV VRDGQRRHPSDN D Sbjct 248 RAPGAGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVPVRDGQRRHPSDNRD 307 Query 302 EPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVA 361 EP RARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV+VRVIPAMTAAQAVA Sbjct 308 EPERARLACALAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVQVRVIPAMTAAQAVA 367 Query 362 SRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMREL 421 SRVGAPLGHDYAVISLSDRLKPW+VIAARL AAAAADLVLAIYNPAS RTWQVGAMR++ Sbjct 368 SRVGAPLGHDYAVISLSDRLKPWEVIAARLEAAAAADLVLAIYNPASKARTWQVGAMRDI 427 Query 422 LLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVD 481 LLA R+PG PVVIGR+ VSGP+EDVRVV+LADL+PAEIDMRCLLIVGSSQT+WYS D Sbjct 428 LLARREPGTPVVIGRD----VSGPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWYSDD 483 Query 482 SQDRVFTPRRY 492 S DRVFTPRRY Sbjct 484 SADRVFTPRRY 494 >gi|118470330|ref|YP_888164.1| cobalamin biosynthesis protein cobIJ [Mycobacterium smegmatis str. MC2 155] gi|118171617|gb|ABK72513.1| cobalamin biosynthesis protein cobIJ [Mycobacterium smegmatis str. MC2 155] Length=503 Score = 776 bits (2004), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/499 (80%), Positives = 429/499 (86%), Gaps = 7/499 (1%) Query 2 SARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEE 61 + GTL+GVGLGPGDPELVTVKAARVIGEADVVAYHSA HG SIARGIAEPYLRPGQLEE Sbjct 4 NKHGTLYGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGQSIARGIAEPYLRPGQLEE 63 Query 62 HLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLH 121 HLVYPVTTE T+HPGGYAGA+EDFYA+A ERIA HL AGR+VALLAEGDPLFYSSYMH+H Sbjct 64 HLVYPVTTETTDHPGGYAGAMEDFYAEAAERIAAHLQAGRDVALLAEGDPLFYSSYMHMH 123 Query 122 TRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVV 181 TRLT RF+AVIVPGVTSVSAASAA TPLV GD+VL++LPGTLP EL RRLAD DAAVV Sbjct 124 TRLTERFDAVIVPGVTSVSAASAATGTPLVQGDEVLTILPGTLPADELKRRLADTDAAVV 183 Query 182 VKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRR 241 +KLGRSY VREALS++G L +AFYVERAST Q+V A +V+ VPYFSL M+PGG Sbjct 184 MKLGRSYTRVREALSSAGRLDEAFYVERASTDRQKVAQAGEVESAKVPYFSLTMVPGGMA 243 Query 242 RALLT---GTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSD 298 R G+V VVGLGPGD DWMTPQSRRELAAATDLIGY YLDRV +R GQR HPSD Sbjct 244 RQEQRPERGSVVVVGLGPGDHDWMTPQSRRELAAATDLIGYGPYLDRVGLRPGQRHHPSD 303 Query 299 NTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQ 358 NTDEP RARLAC+LA QG AVAVVSSGDPGVFAMATAVLEEA+QWPGV VRVIPAMTAAQ Sbjct 304 NTDEPERARLACTLAQQGHAVAVVSSGDPGVFAMATAVLEEAKQWPGVEVRVIPAMTAAQ 363 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 AVASR GAPLGHDYAVISLSDRLKPWDVI RL AAA ADLVLAIYNPAS TRTWQVGAM Sbjct 364 AVASRAGAPLGHDYAVISLSDRLKPWDVIVERLKAAAKADLVLAIYNPASKTRTWQVGAM 423 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+LLL HRDP PV+IGR VSG G E VRVV+LA+L+PA++DMRCLLI+GSSQT+WY Sbjct 424 RDLLLEHRDPSTPVIIGRAVSGARPGEGESVRVVRLAELDPAQVDMRCLLIIGSSQTQWY 483 Query 479 S--VD--SQDRVFTPRRYP 493 S VD ++DRVFTPR YP Sbjct 484 SAAVDDTAEDRVFTPRTYP 502 >gi|126435108|ref|YP_001070799.1| precorrin-3 methyltransferase / precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase [Mycobacterium sp. JLS] gi|126234908|gb|ABN98308.1| precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase [Mycobacterium sp. JLS] Length=495 Score = 766 bits (1978), Expect = 0.0, Method: Compositional matrix adjust. Identities = 401/494 (82%), Positives = 440/494 (90%), Gaps = 5/494 (1%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M RGTL+GVGLGPGDPELVTVKAARVIG+ADVVAYHSA HG SIAR IAEPYLR GQ+E Sbjct 5 MKTRGTLYGVGLGPGDPELVTVKAARVIGQADVVAYHSARHGRSIARRIAEPYLRDGQIE 64 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE T+HPGGYAGA+EDFY +A ERIA HLDAGR+VALLAEGDPLFYSSYMH+ Sbjct 65 EHLVYPVTTEVTDHPGGYAGAMEDFYREAAERIAAHLDAGRDVALLAEGDPLFYSSYMHM 124 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT RF A IVPGVTSVSAASAA+ATPLV G+ VL++LPGTLP EL RRLAD DAAV Sbjct 125 HTRLTERFTAEIVPGVTSVSAASAAIATPLVQGEGVLTILPGTLPADELERRLADTDAAV 184 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVD-ETSVPYFSLAMLPGG 239 V+KLGRSY VR AL+A+G L +AFYVERAST QR L AADVD + VPYFSLAM+PGG Sbjct 185 VLKLGRSYPAVRAALAATGRLDEAFYVERASTPDQRTLSAADVDGDDKVPYFSLAMIPGG 244 Query 240 RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 RR +TG+V VVGLGPG ++WMTPQSRRELAAATDLIGY YLDRV +RDGQ+RHPSDN Sbjct 245 GRRRAVTGSVTVVGLGPGAAEWMTPQSRRELAAATDLIGYGPYLDRVGLRDGQQRHPSDN 304 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQA 359 TDEPARARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV VRVIPAMTAAQA Sbjct 305 TDEPARARLACTLAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVEVRVIPAMTAAQA 364 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 VASRVGAPLGHDYAVISLSDRLKPW++I ARLTAAA ADLVLAIYNPAS TRTWQVGAMR Sbjct 365 VASRVGAPLGHDYAVISLSDRLKPWEIIEARLTAAAQADLVLAIYNPASKTRTWQVGAMR 424 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYS 479 +LLLAHRDPG PVVIGR+ V+G E V+VV+LADL+PA++DMRCLLIVGSSQT+WYS Sbjct 425 DLLLAHRDPGTPVVIGRD----VAGQREHVKVVRLADLDPADVDMRCLLIVGSSQTQWYS 480 Query 480 VDSQDRVFTPRRYP 493 D+ DRVFTPR YP Sbjct 481 DDAGDRVFTPRYYP 494 >gi|108799454|ref|YP_639651.1| precorrin-3 methyltransferase / precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase [Mycobacterium sp. MCS] gi|119868567|ref|YP_938519.1| cobalt-factor II C20-methyltransferase / precorrin-2 C20-methyltransferase / precorrin-3 methyltransferase [Mycobacterium sp. KMS] gi|108769873|gb|ABG08595.1| precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase [Mycobacterium sp. MCS] gi|119694656|gb|ABL91729.1| precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase [Mycobacterium sp. KMS] Length=495 Score = 764 bits (1974), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/494 (81%), Positives = 440/494 (90%), Gaps = 5/494 (1%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M RGTL+GVGLGPGDPELVTVKAARVIG+ADVVAYHSA HG SIAR IAEPYLR GQ+E Sbjct 5 MKTRGTLYGVGLGPGDPELVTVKAARVIGQADVVAYHSARHGRSIARRIAEPYLRDGQIE 64 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE T+HPGGYAGA+EDFY +A ERIA HLDAGR+VALLAEGDPLFYSSYMH+ Sbjct 65 EHLVYPVTTEVTDHPGGYAGAMEDFYREAAERIAAHLDAGRDVALLAEGDPLFYSSYMHM 124 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLT RF A IVPGVTSVSAASAA+ATPLV G+ VL++LPGTLP EL RRLAD DAAV Sbjct 125 HTRLTERFTAEIVPGVTSVSAASAAIATPLVQGEGVLTILPGTLPADELERRLADTDAAV 184 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVD-ETSVPYFSLAMLPGG 239 V+KLGRSY VR AL+A+G L +AFYVERAST QR L AADVD + VPYFSLAM+PGG Sbjct 185 VLKLGRSYPAVRAALAATGRLDEAFYVERASTPDQRTLSAADVDGDDKVPYFSLAMIPGG 244 Query 240 RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 RR +TG+V VVGLGPG ++WMTPQSRRELAAATDLIGY YLDRV +RDGQ+RHPSDN Sbjct 245 GRRRAVTGSVTVVGLGPGAAEWMTPQSRRELAAATDLIGYGPYLDRVGLRDGQQRHPSDN 304 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQA 359 TDEPARARLAC+LA+QGRAVAVVSSGDPGVFAMATAVLEEA+QWPGV VRVIPAMTAAQA Sbjct 305 TDEPARARLACTLAEQGRAVAVVSSGDPGVFAMATAVLEEAKQWPGVEVRVIPAMTAAQA 364 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 VASRVGAPLGHDYAVISLSDRLKPW++I ARLTAAA ADLVLAIYNPAS TRTWQVGAMR Sbjct 365 VASRVGAPLGHDYAVISLSDRLKPWEIIEARLTAAARADLVLAIYNPASKTRTWQVGAMR 424 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYS 479 +LLLAHRDPG PVVIGR+ V+G E V+V++LADL+PA++DMRCLLIVGSSQT+WYS Sbjct 425 DLLLAHRDPGTPVVIGRD----VAGQREHVKVLRLADLDPADVDMRCLLIVGSSQTQWYS 480 Query 480 VDSQDRVFTPRRYP 493 D+ DRVFTPR YP Sbjct 481 DDAGDRVFTPRYYP 494 >gi|120404403|ref|YP_954232.1| precorrin-3B C17-methyltransferase [Mycobacterium vanbaalenii PYR-1] gi|119957221|gb|ABM14226.1| precorrin-2 C20-methyltransferase [Mycobacterium vanbaalenii PYR-1] Length=495 Score = 749 bits (1933), Expect = 0.0, Method: Compositional matrix adjust. Identities = 392/491 (80%), Positives = 435/491 (89%), Gaps = 5/491 (1%) Query 4 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHL 63 +GTLWGVGLGPGDPELVTVKAARVIG ADVVAYHSA HG SIAR IAEPYLR GQ+EEHL Sbjct 8 KGTLWGVGLGPGDPELVTVKAARVIGAADVVAYHSARHGRSIARSIAEPYLREGQIEEHL 67 Query 64 VYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTR 123 VYPVTTE ++HPGGYAGA+EDFY ++ +RIA HLDAGR+VALLAEGDPLFYSSYMH+HTR Sbjct 68 VYPVTTETSDHPGGYAGAMEDFYRESADRIAAHLDAGRDVALLAEGDPLFYSSYMHMHTR 127 Query 124 LTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVK 183 LT RF+A+IVPGVTSVSAASAAV+TPLV GDQVL++LPGTLP EL RRLAD DAAV++K Sbjct 128 LTERFDALIVPGVTSVSAASAAVSTPLVQGDQVLTILPGTLPADELRRRLADTDAAVILK 187 Query 184 LGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRA 243 LGRSY VR+ALSA+G + DAFYVERAST QRVLPA++VD+ SVPYF+L MLPGGRR A Sbjct 188 LGRSYPAVRQALSAAGRIDDAFYVERASTERQRVLPASEVDDQSVPYFALTMLPGGRRAA 247 Query 244 LLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEP 303 +TG+VAVVGLGPGD+ W TPQSR+ LAAATDLIGY YLDRV VRDGQRRHPSDNTDEP Sbjct 248 SVTGSVAVVGLGPGDAGWTTPQSRQVLAAATDLIGYGPYLDRVPVRDGQRRHPSDNTDEP 307 Query 304 ARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQAVASR 363 ARARLAC LA+QGR VAVVSSGDPGVFAMATAVLEEAEQWP V VRV+PAMTAAQAVASR Sbjct 308 ARARLACELAEQGRTVAVVSSGDPGVFAMATAVLEEAEQWPDVDVRVVPAMTAAQAVASR 367 Query 364 VGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLL 423 VGAPLGHDYAVISLSDRLKPWD+IA RLTAAAAAD+VLA+YNPAS TR WQV AMR+LLL Sbjct 368 VGAPLGHDYAVISLSDRLKPWDIIARRLTAAAAADMVLAVYNPASKTRNWQVAAMRDLLL 427 Query 424 AHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY-SVDS 482 HRD PVVIGR+ V+GP E VRVV L +L+PA++DMRCLLIVGSS+TRW+ + D Sbjct 428 EHRDADTPVVIGRD----VAGPRESVRVVPLGELDPADVDMRCLLIVGSSRTRWHTTTDG 483 Query 483 QDRVFTPRRYP 493 DRVFTPR YP Sbjct 484 ADRVFTPRTYP 494 >gi|315444018|ref|YP_004076897.1| precorrin-2 C20-methyltransferase ;precorrin-3 methyltransferase ;cobalt-factor II C20-methyltransferase [Mycobacterium sp. Spyr1] gi|315262321|gb|ADT99062.1| precorrin-2 C20-methyltransferase ;precorrin-3 methyltransferase ;cobalt-factor II C20-methyltransferase [Mycobacterium sp. Spyr1] Length=492 Score = 746 bits (1927), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/495 (81%), Positives = 434/495 (88%), Gaps = 6/495 (1%) Query 1 MSAR-GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQL 59 MSAR GTLWGVGLGPGDPELVTVKAARVIG ADV+AYHSA HG SIAR IAE YLR GQ+ Sbjct 1 MSARQGTLWGVGLGPGDPELVTVKAARVIGAADVIAYHSARHGRSIARSIAEQYLRDGQI 60 Query 60 EEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMH 119 EEHLVYPVTTE + HPGGYAGA+EDFY ++ +RIA HLDAGR+VALLAEGDPLFYSSYMH Sbjct 61 EEHLVYPVTTETSEHPGGYAGAMEDFYRESADRIAAHLDAGRDVALLAEGDPLFYSSYMH 120 Query 120 LHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAA 179 +HTRLT RF+A+IVPGVTSVSAASAAV+TPLV GDQVL++LPGTLP EL RRLAD DAA Sbjct 121 MHTRLTERFDAIIVPGVTSVSAASAAVSTPLVQGDQVLTILPGTLPQAELRRRLADTDAA 180 Query 180 VVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGG 239 V++KLGRSY VR+ALS +G L DAFYVERAST QRVLPAADVD SVPYF+LAML G Sbjct 181 VILKLGRSYPAVRQALSEAGRLDDAFYVERASTERQRVLPAADVDADSVPYFALAMLTGD 240 Query 240 RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 RR + TG+VAVVGLGPGD+ WMTPQSR ELAAATDLIGY YLDRV VR+GQRRHPSDN Sbjct 241 GRRRVGTGSVAVVGLGPGDTAWMTPQSRSELAAATDLIGYGPYLDRVGVREGQRRHPSDN 300 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQA 359 TDEPARARLAC LA+QGRAVAVVSSGDPGVFAMATAVLEEAEQWPGV VRVIPAMTAAQA Sbjct 301 TDEPARARLACELAEQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVDVRVIPAMTAAQA 360 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 VASRVGAPLGHDYAVISLSDRLKPWDVIA RL AAA AD+VLAIYNPAS TRTWQVGAMR Sbjct 361 VASRVGAPLGHDYAVISLSDRLKPWDVIARRLAAAAEADMVLAIYNPASKTRTWQVGAMR 420 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY- 478 +LLL HRDP PVVIGR+ V+GP E V VV L DL+PA +DMRCLLI+GS+QTRW+ Sbjct 421 DLLLEHRDPATPVVIGRD----VAGPRESVTVVALGDLDPATVDMRCLLIIGSTQTRWHR 476 Query 479 SVDSQDRVFTPRRYP 493 + D DRVFT RRYP Sbjct 477 TTDGADRVFTLRRYP 491 >gi|145223691|ref|YP_001134369.1| precorrin-3B C17-methyltransferase [Mycobacterium gilvum PYR-GCK] gi|145216177|gb|ABP45581.1| precorrin-2 C20-methyltransferase / cobalt-factor II C20-methyltransferase [Mycobacterium gilvum PYR-GCK] Length=492 Score = 745 bits (1923), Expect = 0.0, Method: Compositional matrix adjust. Identities = 399/495 (81%), Positives = 433/495 (88%), Gaps = 6/495 (1%) Query 1 MSAR-GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQL 59 MSAR GTLWGVGLGPGDPELVTVKAARVIG ADV+AYHSA HG SIAR IAE YLR GQ+ Sbjct 1 MSARQGTLWGVGLGPGDPELVTVKAARVIGAADVIAYHSARHGRSIARSIAEQYLRDGQI 60 Query 60 EEHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMH 119 EEHLVYPVTTE + HPGGYAGA+EDFY ++ +RIA HLDAGR+VALLAEGDPLFYSSYMH Sbjct 61 EEHLVYPVTTETSEHPGGYAGAMEDFYRESADRIAAHLDAGRDVALLAEGDPLFYSSYMH 120 Query 120 LHTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAA 179 +HTRLT RF+A+IVPGVTSVSAASAAV+TPLV GDQVL++LPGTLP EL RRLAD DAA Sbjct 121 MHTRLTERFDAIIVPGVTSVSAASAAVSTPLVQGDQVLTILPGTLPQAELRRRLADTDAA 180 Query 180 VVVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGG 239 V++KLGRSY VR+ALS +G L DAFYVERAST QRVLPAADVD SVPYF+LAML G Sbjct 181 VILKLGRSYPAVRQALSEAGRLDDAFYVERASTERQRVLPAADVDADSVPYFALAMLTGD 240 Query 240 RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 RR + TG+VAVVGLGPGD+ WMTPQSR ELAAATDLIGY YL+RV VR+GQRRHPSDN Sbjct 241 GRRRVGTGSVAVVGLGPGDTAWMTPQSRSELAAATDLIGYGPYLNRVGVREGQRRHPSDN 300 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQA 359 TDEPARARLAC LA+QGRAVAVVSSGDPGVFAMATAVLEEAEQWPGV VRVIPAMTAAQA Sbjct 301 TDEPARARLACELAEQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVDVRVIPAMTAAQA 360 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 VASRVGAPLGHDYAVISLSDRLKPWDVIA RL AAA AD+VLAIYNPAS TRTWQVGAMR Sbjct 361 VASRVGAPLGHDYAVISLSDRLKPWDVIARRLAAAAEADMVLAIYNPASKTRTWQVGAMR 420 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY- 478 +LLL HRDP PVVIGR+ V+GP E V VV L DL+PA +DMRCLLI+GS+QTRW Sbjct 421 DLLLEHRDPATPVVIGRD----VAGPRESVTVVALGDLDPATVDMRCLLIIGSTQTRWQR 476 Query 479 SVDSQDRVFTPRRYP 493 + D DRVFT RRYP Sbjct 477 TTDGADRVFTLRRYP 491 >gi|169629284|ref|YP_001702933.1| cobalamin biosynthesis protein CobI [Mycobacterium abscessus ATCC 19977] gi|169241251|emb|CAM62279.1| Probable cobalamin biosynthesis protein CobI [Mycobacterium abscessus] Length=499 Score = 676 bits (1745), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/494 (73%), Positives = 403/494 (82%), Gaps = 8/494 (1%) Query 4 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHL 63 RG LWGVGLGPGDPELVTVKAARVIG+ADVVA+HSA HG SIAR IAEPYLRPGQ+EEHL Sbjct 8 RGVLWGVGLGPGDPELVTVKAARVIGDADVVAFHSARHGRSIARSIAEPYLRPGQIEEHL 67 Query 64 VYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTR 123 VYPVTTE T+HPGGY GA++DFY ++ RIA HLD+GRNVALLAEGDPLFYSSYMH+H R Sbjct 68 VYPVTTETTDHPGGYRGAIDDFYEESANRIAAHLDSGRNVALLAEGDPLFYSSYMHMHRR 127 Query 124 LTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVK 183 LT RF+AVI+PGVTS SAASAA TPLV GD++L+V+PGTLP E+TRRL D+ AAV++K Sbjct 128 LTDRFDAVIIPGVTSFSAASAATGTPLVEGDEILTVIPGTLPADEITRRLGDSHAAVIMK 187 Query 184 LGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRA 243 LGRSY VR+AL ASGLL A+YVERAST GQRVLPAA+VD SVPYFSL ++PG + Sbjct 188 LGRSYGAVRQALDASGLLDRAYYVERASTPGQRVLPAAEVDPASVPYFSLVLVPGAQSAT 247 Query 244 LL----TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 + G V V+GLGPG DW T + R+ELA ATDLIGY YLDR+ RDGQ RH SDN Sbjct 248 DIDTDPDGMVTVLGLGPGHHDWTTTEVRQELARATDLIGYGPYLDRIPARDGQVRHASDN 307 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTAAQA 359 DEPARA LA LA GR VAVVSSGDPGVFAMA AVLEEA WP V VRV+PAMTAAQA Sbjct 308 RDEPARAELAFKLAAGGRRVAVVSSGDPGVFAMAAAVLEEARAWPDVTVRVLPAMTAAQA 367 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 VASRVGAPLGHDYAVISLSDRLKPW VI +RL AAAAADLVLA+YNPAS +RTWQV +MR Sbjct 368 VASRVGAPLGHDYAVISLSDRLKPWKVIESRLRAAAAADLVLAVYNPASKSRTWQVASMR 427 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYS 479 ++LL HRDP PVV+GR+ V G E VRV L +L+P +DMR LLI+GSSQT+W+ Sbjct 428 DVLLEHRDPATPVVLGRD----VGGAGESVRVTTLGELDPTVVDMRTLLIIGSSQTQWHD 483 Query 480 VDSQDRVFTPRRYP 493 DS +VFTPRRYP Sbjct 484 TDSGPQVFTPRRYP 497 >gi|226359708|ref|YP_002777486.1| precorrin-2 C(20)-methyltransferase/precorrin-3B C(17)-methyltransferase [Rhodococcus opacus B4] gi|226238193|dbj|BAH48541.1| precorrin-2 C(20)-methyltransferase/precorrin-3B C(17)-methyltransferase [Rhodococcus opacus B4] Length=500 Score = 609 bits (1570), Expect = 4e-172, Method: Compositional matrix adjust. Identities = 318/495 (65%), Positives = 384/495 (78%), Gaps = 10/495 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G LWGVG+GPGDPELVTVKAAR+I EADVVA+HSA HG SI+R +A PYLR GQ+EEHLV Sbjct 9 GKLWGVGIGPGDPELVTVKAARIITEADVVAFHSARHGKSISRAVAAPYLRDGQIEEHLV 68 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE +HPGGY GA+++FY +A++R+A HL+AGR+VALLA GDPLFYSSYMH+H RL Sbjct 69 YPVTTETVDHPGGYQGAMDEFYEEASQRLAAHLEAGRSVALLAAGDPLFYSSYMHMHKRL 128 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 +RF A ++PGVTS+SAASAA+A PLV G+++L+VLPGTLP GELTRRL + DAA ++KL Sbjct 129 AQRFEAEVIPGVTSISAASAALAMPLVEGEEILTVLPGTLPRGELTRRLRETDAAAILKL 188 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR+Y VR+AL SG + + +YVERAST Q++ A DV ++ VPYFS+A++P R Sbjct 189 GRTYPAVRQALKDSGRIDETWYVERASTTRQKIDHADDVSDSDVPYFSIAIVPSPSNARR 248 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 A G + VVGLGPGD W TP+ + EL+ ATDL+GY Y+DRV R GQRRH SDN Sbjct 249 EDAPPQGELVVVGLGPGDQSWTTPEVQHELSLATDLVGYGPYIDRVPERPGQRRHSSDNR 308 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAMTAAQ 358 E RA +A LA G VAVVSSGDPGVF A A + EQW GV VRV+P MTAA Sbjct 309 VEAERAAMALDLAKNGARVAVVSSGDPGVFAMAAAVLEVAAEEQWRGVPVRVLPGMTAAN 368 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 AVASRVGAPLGHDYAV+SLSDRLKPWDV+A R++A A+AD+ A+YNPAS +RTWQV AM Sbjct 369 AVASRVGAPLGHDYAVLSLSDRLKPWDVVAQRISAVASADMAFAVYNPASKSRTWQVAAM 428 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+L+L HR P PV+IGR+ V+GP E VRVV+LADL+PAEIDMRCLLIVGSS T Sbjct 429 RDLVLEHRSPDTPVIIGRD----VAGPQESVRVVRLADLDPAEIDMRCLLIVGSSMTTVV 484 Query 479 SVDSQDRVFTPRRYP 493 + RVFTPRRYP Sbjct 485 ENEHGTRVFTPRRYP 499 >gi|312139748|ref|YP_004007084.1| s-adenosyl-l-methionine-precorrin-2 methyl transferase + precorrin-3 methylase [Rhodococcus equi 103S] gi|311889087|emb|CBH48400.1| S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase [Rhodococcus equi 103S] Length=496 Score = 608 bits (1569), Expect = 5e-172, Method: Compositional matrix adjust. Identities = 317/499 (64%), Positives = 387/499 (78%), Gaps = 10/499 (2%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSA G LWGVG+GPGDPEL+TVKAARVIGEADVVA+HSA HG SI+RG+A PY+R GQ+E Sbjct 1 MSANGKLWGVGIGPGDPELMTVKAARVIGEADVVAFHSARHGRSISRGVAAPYMREGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE +HPGGY GA+++FY A ER+A HL+AGR+VALLA GDPLFYSSYMH+ Sbjct 61 EHLVYPVTTETIDHPGGYQGAMDEFYEQAAERLAAHLEAGRSVALLAAGDPLFYSSYMHM 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 H RL RF A ++PGVT+VSAASAA+A PLV G++VL+VLPGTLP ELTRRL + DAA Sbjct 121 HKRLADRFEAEVIPGVTAVSAASAALAEPLVEGEEVLTVLPGTLPQEELTRRLRETDAAA 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP--- 237 ++KLGR+Y VR+AL SG + + +YVERAST QRV A DV++ VPYF++A++P Sbjct 181 IMKLGRTYPAVRQALKDSGRIDETYYVERASTDRQRVAKADDVEDADVPYFAIAVVPSPV 240 Query 238 GGRRRALLT-GTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 R A + G V VVGLGPGD W TP+ R+ELA ATDL+GY Y+DRV +R GQRRH Sbjct 241 NNRVEAEPSRGEVVVVGLGPGDQAWTTPEVRQELALATDLVGYTTYIDRVPIRPGQRRHA 300 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAM 354 SDN E RA +A +A +G VAVVSSGDPGVF A A + EQW V VR++P M Sbjct 301 SDNRVEAERAAMALDMAKRGARVAVVSSGDPGVFAMAAAVLEVAAEEQWRDVPVRILPGM 360 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAA AVASRVGAPLGHDYA++SLSDRLKPWD++A R++A A+AD+ A+YNPAS +RTWQ Sbjct 361 TAANAVASRVGAPLGHDYAMLSLSDRLKPWDIVAKRVSAVASADMAFAVYNPASKSRTWQ 420 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 V AMR+L+L HR P PV+IGR+ V+GP E +++V+LADL+PA++DMRCLLIVGSSQ Sbjct 421 VAAMRDLVLEHRSPDTPVIIGRD----VAGPEESIKIVRLADLDPADVDMRCLLIVGSSQ 476 Query 475 TRWYSVDSQDRVFTPRRYP 493 T S VFTPR YP Sbjct 477 TTVVESASGTTVFTPRHYP 495 >gi|325676800|ref|ZP_08156473.1| bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J [Rhodococcus equi ATCC 33707] gi|325552348|gb|EGD22037.1| bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J [Rhodococcus equi ATCC 33707] Length=496 Score = 607 bits (1566), Expect = 1e-171, Method: Compositional matrix adjust. Identities = 317/499 (64%), Positives = 386/499 (78%), Gaps = 10/499 (2%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSA G LWGVG+GPGDPEL+TVKAARVIGEADVVA+HSA HG SI+RG+A PY+R GQ+E Sbjct 1 MSANGKLWGVGIGPGDPELMTVKAARVIGEADVVAFHSARHGRSISRGVAAPYMREGQIE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE +HPGGY GA+++FY A ER+A HL+AGR+VALLA GDPLFYSSYMH+ Sbjct 61 EHLVYPVTTETIDHPGGYQGAMDEFYEQAAERLAAHLEAGRSVALLAAGDPLFYSSYMHM 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 H RL RF A ++PGVT+VSAASAA+A PLV G++VL+VLPGTLP ELTRRL + DAA Sbjct 121 HKRLADRFEAEVIPGVTAVSAASAALAEPLVEGEEVLTVLPGTLPQEELTRRLRETDAAA 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP--- 237 ++KLGR+Y VR+AL SG + + +YVERAST QRV A DV++ VPYF++A++P Sbjct 181 IMKLGRTYPAVRQALKDSGRIDETYYVERASTDRQRVAKADDVEDADVPYFAIAVVPSPV 240 Query 238 GGRRRALLT-GTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 R A + G V VVGLGPGD W TP+ R+ELA ATDL+GY Y+DRV +R GQRRH Sbjct 241 NNRVEAEPSRGEVVVVGLGPGDQAWTTPEVRQELALATDLVGYTTYIDRVPIRPGQRRHA 300 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAM 354 SDN E RA +A +A +G VAVVSSGDPGVF A A + EQW V VR++P M Sbjct 301 SDNRVEAERAAMALDMAKRGARVAVVSSGDPGVFAMAAAVLEVAAEEQWRDVPVRILPGM 360 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAA AVASRVGAPLGHDYA++SLSDRLKPWD++A R++A A+AD+ A+YNPAS +RTWQ Sbjct 361 TAANAVASRVGAPLGHDYAMLSLSDRLKPWDIVAKRVSAVASADMAFAVYNPASKSRTWQ 420 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 V AMR+L+L HR P PV+IGR+ V+GP E + +V+LADL+PA++DMRCLLIVGSSQ Sbjct 421 VAAMRDLVLEHRSPDTPVIIGRD----VAGPEESITIVRLADLDPADVDMRCLLIVGSSQ 476 Query 475 TRWYSVDSQDRVFTPRRYP 493 T S VFTPR YP Sbjct 477 TTVIESASGTTVFTPRHYP 495 >gi|111017196|ref|YP_700168.1| bifunctional S-adenosyl-L-methionine-precorrin-2 methyl transferase/precorrin-3 methylase Cob I/J [Rhodococcus jostii RHA1] gi|110816726|gb|ABG92010.1| probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase [Rhodococcus jostii RHA1] Length=500 Score = 597 bits (1539), Expect = 2e-168, Method: Compositional matrix adjust. Identities = 319/495 (65%), Positives = 382/495 (78%), Gaps = 10/495 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G LWGVG+GPGDPELVTVKAARVI EADVVA+HSA HG SI+R +A PYLR GQ+EEHLV Sbjct 9 GKLWGVGIGPGDPELVTVKAARVIAEADVVAFHSARHGKSISRAVAAPYLREGQIEEHLV 68 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE +HPGGY GA+++FY +A++R+A HLDAGR+VALLA GDPLFYSSYMH+H RL Sbjct 69 YPVTTETVDHPGGYQGAMDEFYEEASQRLAAHLDAGRSVALLAAGDPLFYSSYMHMHKRL 128 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 RF A +VPGVTS+SAASAA+A PLV G+++L+VLPGT+P GELTRRL + DAA ++KL Sbjct 129 VPRFEAEVVPGVTSISAASAALAMPLVEGEEILTVLPGTMPPGELTRRLRETDAAAILKL 188 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR+Y VR+AL SG + + +YVERAST Q++ A DV ++ VPYFS+A++P R Sbjct 189 GRTYPAVRQALKDSGRIDETWYVERASTTRQKIDAADDVSDSDVPYFSIAIVPSPSNARR 248 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 A G + VVGLGPGD W TP+ + EL+ ATDL+GY Y+DRV R GQRRH SDN Sbjct 249 DDAAPQGELVVVGLGPGDQAWTTPEVQHELSLATDLVGYGPYIDRVPERPGQRRHSSDNR 308 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAMTAAQ 358 E RA +A LA G VAVVSSGDPGVF A A + EQW GV VRV+P MTAA Sbjct 309 VEAERAAMALDLAKNGSRVAVVSSGDPGVFAMAAAVLEVAAEEQWRGVPVRVLPGMTAAN 368 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 AVASRVGAPLGHDYAV+SLSDRLKPWDV+A R++A A+AD+ A+YNPAS +RTWQV AM Sbjct 369 AVASRVGAPLGHDYAVLSLSDRLKPWDVVAQRISAVASADMAFAVYNPASKSRTWQVAAM 428 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+L+L HR P PV+IGR+ V+G E VRVV+LADL+PAEIDMRCLLIVGSS T Sbjct 429 RDLVLEHRSPDTPVIIGRD----VAGAQESVRVVRLADLDPAEIDMRCLLIVGSSMTTVV 484 Query 479 SVDSQDRVFTPRRYP 493 + RVFTPRRYP Sbjct 485 ENEHGTRVFTPRRYP 499 >gi|226306631|ref|YP_002766591.1| precorrin-2 C(20)-methyltransferase/precorrin-3B C(17)-methyltransferase [Rhodococcus erythropolis PR4] gi|226185748|dbj|BAH33852.1| precorrin-2 C(20)-methyltransferase/precorrin-3B C(17)-methyltransferase [Rhodococcus erythropolis PR4] Length=495 Score = 596 bits (1536), Expect = 3e-168, Method: Compositional matrix adjust. Identities = 319/500 (64%), Positives = 377/500 (76%), Gaps = 11/500 (2%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSA G LWGVG+GPGDPELVTVKAARVIGEADVVA+HSA HG SI+RG+A PY+R GQ+E Sbjct 1 MSA-GKLWGVGIGPGDPELVTVKAARVIGEADVVAFHSARHGKSISRGVAAPYMREGQIE 59 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE +HPGGY GA+++FY A ER+A HL AGR VALLA GDPLFYSSYMH+ Sbjct 60 EHLVYPVTTETVDHPGGYQGAMDEFYEAAAERLAVHLAAGRTVALLAAGDPLFYSSYMHM 119 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 H RL RF+A ++PGVTSVSAASAA+ PLV G+++L++LPGTLP ELTRRL + DAA Sbjct 120 HKRLADRFDAEVIPGVTSVSAASAALGKPLVEGEEILTILPGTLPQAELTRRLKETDAAA 179 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP--- 237 ++KLGR++ V ++L SG L +A YVERAST QRV AA+VD VPYFS+A++P Sbjct 180 ILKLGRTFPPVLQSLEDSGRLDEAHYVERASTTRQRVETAAEVDPDGVPYFSIAIVPSPS 239 Query 238 -GGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 R G V VVGLGPGD+ W TP+ EL+ ATDL+GY Y+DRV R GQRRH Sbjct 240 NNPRPATESRGEVVVVGLGPGDTAWTTPEVAHELSLATDLVGYGPYVDRVPTRPGQRRHS 299 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAM 354 SDN E RA +A LA G VAVVSSGDPGVF A A + +QW GV VR++P M Sbjct 300 SDNRVEAERAAMALDLAKNGARVAVVSSGDPGVFAMAAAVLEVAAEDQWRGVPVRILPGM 359 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAA AVASRVGAPLGHDYAV+SLSDRLKPWDV+A R++A AAAD+ A+YNPAS +RTWQ Sbjct 360 TAANAVASRVGAPLGHDYAVLSLSDRLKPWDVVARRISAVAAADMAFAVYNPASKSRTWQ 419 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 V AM++L+L HR P PVVIGR+ V+G E VRVV L +L P+EIDMR LLIVGSS Sbjct 420 VQAMKDLVLEHRSPETPVVIGRD----VAGAEESVRVVTLGELEPSEIDMRTLLIVGSSM 475 Query 475 TRWYSVDSQDRVFTPRRYPE 494 T S +VFTPRRYPE Sbjct 476 TTVVETGSGRQVFTPRRYPE 495 >gi|305407948|dbj|BAJ15905.1| S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase [Rhodococcus opacus] Length=500 Score = 595 bits (1534), Expect = 6e-168, Method: Compositional matrix adjust. Identities = 317/495 (65%), Positives = 382/495 (78%), Gaps = 10/495 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G LWGVG+GPGDPELVTVKAARVI EADVVA+HSA HG SI+R +A PYLR GQ+EEHLV Sbjct 9 GKLWGVGIGPGDPELVTVKAARVIAEADVVAFHSARHGKSISRAVAAPYLRDGQIEEHLV 68 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVT E +HPGGY GA+++FY +A++R+A HL+AGR+VALLA GDPLFYSSYMH+H RL Sbjct 69 YPVTIETVDHPGGYQGAMDEFYEEASQRLAAHLEAGRSVALLAAGDPLFYSSYMHMHKRL 128 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 +RF A ++PGVTS+SAASAA+A PLV G+++L+VLPGTLP GELTRRL + DAA ++KL Sbjct 129 AQRFEAEVIPGVTSISAASAALAMPLVEGEEILTVLPGTLPRGELTRRLRETDAAAILKL 188 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR+Y VR+AL SG + + +YVERAST Q++ A DV ++ VPYFS+A++P R Sbjct 189 GRTYPAVRQALKDSGRIDETWYVERASTTRQKIDAADDVSDSDVPYFSIAIVPSPSNARR 248 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 A G + VVGLGPGD W TP+ + EL+ ATDL+GY Y+DRV R GQRRH SDN Sbjct 249 DDAAPQGELVVVGLGPGDQAWTTPEVQHELSLATDLVGYGPYIDRVPERPGQRRHSSDNR 308 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAMTAAQ 358 E RA +A LA G VAVVSSGDPGVF A A + EQW GV VRV+P MTAA Sbjct 309 VEAERAAMALDLAKNGARVAVVSSGDPGVFAMAAAVLEVAAEEQWRGVPVRVLPGMTAAN 368 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 AVASRVGAPLGHDYAV+SLSDRLKPWDV+A R++A A+AD+ A+YNPAS +RTWQV AM Sbjct 369 AVASRVGAPLGHDYAVLSLSDRLKPWDVVAQRISAVASADMAFAVYNPASKSRTWQVAAM 428 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+L+L HR P PV+IGR+ V+G E VRVV+LADL+PAEIDMRCLLIVGSS T Sbjct 429 RDLVLEHRSPDTPVIIGRD----VAGAQESVRVVRLADLDPAEIDMRCLLIVGSSMTTVV 484 Query 479 SVDSQDRVFTPRRYP 493 + RVFTPRRYP Sbjct 485 ENEHGTRVFTPRRYP 499 >gi|229493684|ref|ZP_04387469.1| cobalamin biosynthesis protein cobIJ [Rhodococcus erythropolis SK121] gi|229319645|gb|EEN85481.1| cobalamin biosynthesis protein cobIJ [Rhodococcus erythropolis SK121] Length=495 Score = 593 bits (1529), Expect = 2e-167, Method: Compositional matrix adjust. Identities = 318/500 (64%), Positives = 376/500 (76%), Gaps = 11/500 (2%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSA G LWGVG+GPGDPELVTVKAARVIGEADVVA+HSA HG SI+RG+A PY+R GQ+E Sbjct 1 MSA-GKLWGVGIGPGDPELVTVKAARVIGEADVVAFHSARHGKSISRGVAAPYMREGQIE 59 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTE +HPGGY GA+++FY A ER+A HL AGR VALLA GDPLFYSSYMH+ Sbjct 60 EHLVYPVTTETVDHPGGYQGAMDEFYEAAAERLAVHLAAGRTVALLAAGDPLFYSSYMHM 119 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 H RL RF+A ++PGVTSVSAASAA+ PLV G+++L++LPGTLP ELTRRL + DAA Sbjct 120 HKRLADRFDAEVIPGVTSVSAASAALGKPLVEGEEILTILPGTLPQAELTRRLKETDAAA 179 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP--- 237 ++KLGR++ V ++L SG L +A YVERAST QRV AA+VD VPYFS+A++P Sbjct 180 ILKLGRTFPPVLQSLEDSGRLDEAHYVERASTTRQRVESAAEVDPDGVPYFSIAIVPSPS 239 Query 238 -GGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 R G V VVGLGPGD+ W TP+ EL+ ATDL+GY Y+DRV R GQRRH Sbjct 240 NNPRPATESRGEVVVVGLGPGDTAWTTPEVAHELSFATDLVGYGPYVDRVPTRPGQRRHS 299 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVF--AMATAVLEEAEQWPGVRVRVIPAM 354 SDN E RA +A LA G VAVVSSGDPGVF A A + +QW GV VR++P M Sbjct 300 SDNRVEAERAAMALDLAKNGARVAVVSSGDPGVFAMAAAVLEVAAEDQWRGVPVRILPGM 359 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAA AVASRVGAPLGHDYAV+SLSDRLKPWDV+A R++A AAAD+ A+YNPAS +RTWQ Sbjct 360 TAANAVASRVGAPLGHDYAVLSLSDRLKPWDVVARRISAVAAADMAFAVYNPASKSRTWQ 419 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 V AM++L+L HR P PVVIGR+ V+G E VRVV L +L P+EIDMR LLIVGSS Sbjct 420 VQAMKDLVLEHRSPETPVVIGRD----VAGAEESVRVVTLGELEPSEIDMRTLLIVGSSM 475 Query 475 TRWYSVDSQDRVFTPRRYPE 494 T S +VFT RRYPE Sbjct 476 TTVVETGSGRQVFTSRRYPE 495 >gi|134102398|ref|YP_001108059.1| precorrin-3B C17-methyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|133915021|emb|CAM05134.1| precorrin-3B C17-methyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=505 Score = 591 bits (1524), Expect = 9e-167, Method: Compositional matrix adjust. Identities = 319/508 (63%), Positives = 373/508 (74%), Gaps = 19/508 (3%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 M +GTL+GVGLGPGDPELVTVKAAR+I A+VVAYH A HG SIAR +AEPYLRPGQ+E Sbjct 1 MEHKGTLYGVGLGPGDPELVTVKAARLIESAEVVAYHCARHGRSIARSVAEPYLRPGQVE 60 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 E LVYPVTTE T+HPGGY GA+++FY A ER+A HLDAGR+V LLAEGDPLFY SYMH+ Sbjct 61 ERLVYPVTTETTDHPGGYQGAIDEFYERAAERLAEHLDAGRDVVLLAEGDPLFYGSYMHM 120 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 H RL RF A +VPGVTSVS ASA + +PL D+VL+VLPGTL L RLA DAA Sbjct 121 HKRLAGRFEAHVVPGVTSVSGASAVLGSPLAERDEVLTVLPGTLEPEVLAERLASTDAAA 180 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP--- 237 V+KLGR++ VREAL +G L A+YVERA+T QRV P A+VD SVPYFSLA+LP Sbjct 181 VLKLGRTFDGVREALEKAGRLDQAWYVERATTEKQRVEPLAEVDPDSVPYFSLALLPSPV 240 Query 238 --GGRRRALL---------TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRV 286 GG R G V VVGLGP +W TP++ +A A DL+GY YL R+ Sbjct 241 NAGGPFRTARPASESQGRNQGEVVVVGLGPAGREWTTPEALAAVAEADDLVGYGPYLARL 300 Query 287 EVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGV 346 Q +H SDN E RA A LA +G VAVVSSGDPGVFAMA+AVLE A + V Sbjct 301 PDNPRQLKHASDNRVEAERAEFALELARRGSRVAVVSSGDPGVFAMASAVLEVAAEKGDV 360 Query 347 RVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNP 406 VRV+P +TAAQAVASRVGAPLGHD+ V+SLSDRLKPW+VI RL A AAADLV+A+YNP Sbjct 361 PVRVLPGLTAAQAVASRVGAPLGHDFCVLSLSDRLKPWEVIVDRLRAVAAADLVIAVYNP 420 Query 407 ASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRC 466 AS +RTWQVGA R++LL HR P PVVIGR+ V GP E VRVV+LADL+ +++DMRC Sbjct 421 ASRSRTWQVGAARDVLLEHRSPDTPVVIGRD----VGGPQESVRVVRLADLDQSDVDMRC 476 Query 467 LLIVGSSQTRWY-SVDSQDRVFTPRRYP 493 LL+VGSS TR VD +D VFTPRRYP Sbjct 477 LLLVGSSTTRIAPGVDGRDVVFTPRRYP 504 >gi|291004217|ref|ZP_06562190.1| precorrin-3B C17-methyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=511 Score = 590 bits (1522), Expect = 1e-166, Method: Compositional matrix adjust. Identities = 318/505 (63%), Positives = 372/505 (74%), Gaps = 19/505 (3%) Query 4 RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHL 63 +GTL+GVGLGPGDPELVTVKAAR+I A+VVAYH A HG SIAR +AEPYLRPGQ+EE L Sbjct 10 KGTLYGVGLGPGDPELVTVKAARLIESAEVVAYHCARHGRSIARSVAEPYLRPGQVEERL 69 Query 64 VYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTR 123 VYPVTTE T+HPGGY GA+++FY A ER+A HLDAGR+V LLAEGDPLFY SYMH+H R Sbjct 70 VYPVTTETTDHPGGYQGAIDEFYERAAERLAEHLDAGRDVVLLAEGDPLFYGSYMHMHKR 129 Query 124 LTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVK 183 L RF A +VPGVTSVS ASA + +PL D+VL+VLPGTL L RLA DAA V+K Sbjct 130 LAGRFEAHVVPGVTSVSGASAVLGSPLAERDEVLTVLPGTLEPEVLAERLASTDAAAVLK 189 Query 184 LGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP-----G 238 LGR++ VREAL +G L A+YVERA+T QRV P A+VD SVPYFSLA+LP G Sbjct 190 LGRTFDGVREALEKAGRLDQAWYVERATTEKQRVEPLAEVDPDSVPYFSLALLPSPVNAG 249 Query 239 GRRRALL---------TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVR 289 G R G V VVGLGP +W TP++ +A A DL+GY YL R+ Sbjct 250 GPFRTARPASESQGRNQGEVVVVGLGPAGREWTTPEALAAVAEADDLVGYGPYLARLPDN 309 Query 290 DGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVR 349 Q +H SDN E RA A LA +G VAVVSSGDPGVFAMA+AVLE A + V VR Sbjct 310 PRQLKHASDNRVEAERAEFALELARRGSRVAVVSSGDPGVFAMASAVLEVAAEKGDVPVR 369 Query 350 VIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASV 409 V+P +TAAQAVASRVGAPLGHD+ V+SLSDRLKPW+VI RL A AAADLV+A+YNPAS Sbjct 370 VLPGLTAAQAVASRVGAPLGHDFCVLSLSDRLKPWEVIVDRLRAVAAADLVIAVYNPASR 429 Query 410 TRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLI 469 +RTWQVGA R++LL HR P PVVIGR+ V GP E VRVV+LADL+ +++DMRCLL+ Sbjct 430 SRTWQVGAARDVLLEHRSPDTPVVIGRD----VGGPQESVRVVRLADLDQSDVDMRCLLL 485 Query 470 VGSSQTRWY-SVDSQDRVFTPRRYP 493 VGSS TR VD +D VFTPRRYP Sbjct 486 VGSSTTRIAPGVDGRDVVFTPRRYP 510 >gi|54025121|ref|YP_119363.1| putative precorrin 2 methyltransferase/precorrin 3B methyltransferase [Nocardia farcinica IFM 10152] gi|54016629|dbj|BAD57999.1| putative precorrin 2 methyltransferase/precorrin 3B methyltransferase [Nocardia farcinica IFM 10152] Length=536 Score = 589 bits (1518), Expect = 4e-166, Method: Compositional matrix adjust. Identities = 330/529 (63%), Positives = 385/529 (73%), Gaps = 47/529 (8%) Query 3 ARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEH 62 A G LWGVGLGPGDPELVTVKAARVI ADV+A+HSA HG SI+RGIA PY+RPGQLEEH Sbjct 7 APGKLWGVGLGPGDPELVTVKAARVIAAADVIAFHSARHGRSISRGIAAPYMRPGQLEEH 66 Query 63 LVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHT 122 L+YPVTTE T+HPGGY GA+++FYA+A ER+ATHL AGR+VALLA GDPLFYSSYMH+H Sbjct 67 LIYPVTTETTDHPGGYQGAIDEFYAEAAERLATHLAAGRSVALLAAGDPLFYSSYMHMHR 126 Query 123 RLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVV 182 RL RF A I+PG+TSVSAASAA+ TPLV G+QVL+VLPGT+PV ELTRRL D DAA ++ Sbjct 127 RLADRFEAEIIPGITSVSAASAALGTPLVEGEQVLTVLPGTMPVDELTRRLRDTDAAAIM 186 Query 183 KLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRR 242 KLGR+Y VR+ALS +G L DA+YVERAS+ +RVL A +VD+ VPYFS+ ++PG R Sbjct 187 KLGRTYPGVRQALSDAGRLDDAYYVERASSDRERVLRAGEVDDADVPYFSITLVPGPR-- 244 Query 243 ALLTGTVAVVGLGP-------------------------------------GDSDWMTPQ 265 T + V GP G+ +W TP+ Sbjct 245 --PTTPLPRVDAGPRAASARREDAPAEPATRPDSAPSSPTVGEVVVVGLGPGNPEWTTPE 302 Query 266 SRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSG 325 R LAAATDL+GY Y+DRV R GQRRH SDN E RA +A LA +G VAVVSSG Sbjct 303 VREALAAATDLVGYTTYIDRVPHRPGQRRHASDNRVESERAAMALDLALRGARVAVVSSG 362 Query 326 DPGVFAMATAVLEEA--EQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKP 383 DPGVFAMA AVLEE+ +W V VRV+P +TAA AVASRVGAPLGHDYA+ISLSDRLKP Sbjct 363 DPGVFAMAAAVLEESADPRWRAVPVRVLPGLTAANAVASRVGAPLGHDYAMISLSDRLKP 422 Query 384 WDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVS 443 WDV+A RL A AAAD+ +AIYNPAS RTWQVGAMREL+L HR P PVVIGR+ V Sbjct 423 WDVVAKRLAAVAAADMAIAIYNPASSQRTWQVGAMRELVLEHRTPDTPVVIGRD----VG 478 Query 444 GPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRY 492 GP E VRVV LADL+PAE+DMR LLI+G+S T RV+T RRY Sbjct 479 GPTERVRVVTLADLDPAEVDMRTLLIIGASTTATVDSAHGTRVYTSRRY 527 >gi|296270460|ref|YP_003653092.1| precorrin-3B C17-methyltransferase [Thermobispora bispora DSM 43833] gi|296093247|gb|ADG89199.1| precorrin-3B C17-methyltransferase [Thermobispora bispora DSM 43833] Length=495 Score = 572 bits (1474), Expect = 5e-161, Method: Compositional matrix adjust. Identities = 319/497 (65%), Positives = 376/497 (76%), Gaps = 15/497 (3%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDPEL+TVKAAR+IGEADV+AYH+A HG SIAR IAEPYLR GQ+EE L+ Sbjct 6 GRLYGVGLGPGDPELITVKAARLIGEADVIAYHAARHGRSIARSIAEPYLRAGQIEEPLL 65 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T HPGGY GALEDFYA+ T R+A HLDAGR V +L EGDPLFY SYMHLH RL Sbjct 66 YPVTTETTTHPGGYQGALEDFYAECTARLAAHLDAGRTVVVLCEGDPLFYGSYMHLHKRL 125 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ A +VPGVTSVSAA+A + PLV D++L+VLPGTLP GEL RL +DAA V+KL Sbjct 126 AHRYPATVVPGVTSVSAAAAVLGRPLVERDEILTVLPGTLPAGELADRLRRSDAAAVLKL 185 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAML--PGG--- 239 GR++ VR+A +A+G L DA+YVERA+ AG+RV P +VD VPYFSLA+L PGG Sbjct 186 GRTFEKVRDAFAAAGRLDDAWYVERATMAGERVAPLREVDPDGVPYFSLALLAGPGGGAV 245 Query 240 ---RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 R + V VVGLGP W+TP+++ LA+ATDL+GY YLDRV QRRHP Sbjct 246 PPEPPRPAVAPEVVVVGLGPAGRPWLTPEAQEALASATDLVGYGPYLDRVPPNPRQRRHP 305 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWPGVRVRVIPAMTA 356 + N E RAR A LA +GR VAVVSSGDPGVFAMA+AVLE AE +P V VRV+P +TA Sbjct 306 TGNRVEAERARHALELAREGRRVAVVSSGDPGVFAMASAVLEAAEDYPDVPVRVVPGITA 365 Query 357 AQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVG 416 AQAVA+R GAPLGHD+ V+SLSD LKPW+VIA RLTAAA ADLV+AIYNPAS RTWQ+ Sbjct 366 AQAVAARAGAPLGHDFCVLSLSDLLKPWEVIAERLTAAARADLVIAIYNPASRHRTWQLP 425 Query 417 AMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTR 476 A R+LLL HR P PVVIGR+ V GP E + V LA L+PA +DMRCLLI+GSS T Sbjct 426 AARDLLLEHRSPDTPVVIGRD----VGGPEESLTVTTLAALDPATVDMRCLLIIGSSTT- 480 Query 477 WYSVDSQDRVFTPRRYP 493 V ++ V+TPRRYP Sbjct 481 --RVTTRGTVYTPRRYP 495 Score = 42.0 bits (97), Expect = 0.28, Method: Compositional matrix adjust. Identities = 50/182 (28%), Positives = 79/182 (44%), Gaps = 34/182 (18%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRG---------YLDRVEVRDGQRRH 295 +TG + VGLGPGD + +T ++ R + A D+I Y + +R GQ Sbjct 4 MTGRLYGVGLGPGDPELITVKAARLIGEA-DVIAYHAARHGRSIARSIAEPYLRAGQIEE 62 Query 296 P------SDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATAV 336 P ++ T P ARLA L D GR V V+ GDP + + Sbjct 63 PLLYPVTTETTTHPGGYQGALEDFYAECTARLAAHL-DAGRTVVVLCEGDPLFYGSYMHL 121 Query 337 LEE-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAA 395 + A ++P V+P +T+ A A+ +G PL ++++ P +A RL + Sbjct 122 HKRLAHRYPAT---VVPGVTSVSAAAAVLGRPLVERDEILTVLPGTLPAGELADRLRRSD 178 Query 396 AA 397 AA Sbjct 179 AA 180 >gi|302554740|ref|ZP_07307082.1| precorrin-3B C17-methyltransferase [Streptomyces viridochromogenes DSM 40736] gi|302472358|gb|EFL35451.1| precorrin-3B C17-methyltransferase [Streptomyces viridochromogenes DSM 40736] Length=508 Score = 571 bits (1472), Expect = 9e-161, Method: Compositional matrix adjust. Identities = 309/503 (62%), Positives = 375/503 (75%), Gaps = 11/503 (2%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 S G L+GVGLGPGDP L+TV+A V+ EADV+AYHSA HG SIAR IA ++R +E Sbjct 5 QSNAGRLYGVGLGPGDPSLMTVRAVEVMAEADVIAYHSARHGRSIARSIAAKHIREDHIE 64 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 E LVYPVTTE T+HPGGY GA+E+FYA+A+ R+A HLDAGR VA+LAEGDP+FY SYMH+ Sbjct 65 ERLVYPVTTETTDHPGGYKGAMEEFYAEASARLAAHLDAGRTVAVLAEGDPMFYGSYMHM 124 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 H RL R+ ++PGVTSVSAA+A + TPL G++VL++LPGTLP ELT RLA DAAV Sbjct 125 HKRLADRYATEVIPGVTSVSAAAARLGTPLAEGEEVLTILPGTLPEEELTARLASTDAAV 184 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGG- 239 V+KLGR++ VR+A + SG LG+A YVERA+ AG+R+ ADVD SVPYFS+A+LP Sbjct 185 VMKLGRTFTKVRQAFADSGRLGEARYVERATMAGERLAELADVDAESVPYFSVAVLPSQV 244 Query 240 ---RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 R R G V VVG GP W+TP++R LAAA DL+GY YLDRV R GQ RH Sbjct 245 DAERPRTPERGEVVVVGTGPAGPLWLTPETRGALAAADDLVGYTTYLDRVPERPGQTRHG 304 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEA--EQWPGVRVRVIPAM 354 SDN E RA A LA +GR VAVVS GDPGVFAMATAVLE A +++ V VRV+P + Sbjct 305 SDNRVESERAEFALDLAGRGRRVAVVSGGDPGVFAMATAVLEVASRKEYADVPVRVLPGV 364 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAA A A+R GAPLGHDYAV+SLSDRLKPW+VIA RL +AA+ADLVLA+YNP S +RTWQ Sbjct 365 TAANAAAARAGAPLGHDYAVLSLSDRLKPWEVIAERLRSAASADLVLALYNPGSRSRTWQ 424 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 VG RELLL HR P PVV+ R+ V G E VR+V+L+DL+PAE+DMR +L+VGSSQ Sbjct 425 VGKARELLLEHRAPDTPVVVARD----VGGTGERVRIVRLSDLDPAEVDMRTILLVGSSQ 480 Query 475 TRWYSV-DSQDRVFTPRRYPEAG 496 TR D ++ +TPRRYPE G Sbjct 481 TRAVRRGDGEEIAWTPRRYPETG 503 >gi|284032968|ref|YP_003382899.1| precorrin-3B C17-methyltransferase [Kribbella flavida DSM 17836] gi|283812261|gb|ADB34100.1| precorrin-3B C17-methyltransferase [Kribbella flavida DSM 17836] Length=511 Score = 569 bits (1466), Expect = 5e-160, Method: Compositional matrix adjust. Identities = 312/511 (62%), Positives = 372/511 (73%), Gaps = 14/511 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G LWGVGLGPGDPELVTVKAAR+IG ADV+A+HSA HG SIAR +A PYLR GQ+EEHLV Sbjct 3 GRLWGVGLGPGDPELVTVKAARLIGAADVIAFHSARHGRSIARSVAAPYLRDGQVEEHLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YP+TTE T+HPGGY GA++DFYAD R+A HLDAGR+V +LAEGDPLFY SYMH+H RL Sbjct 63 YPLTTETTDHPGGYQGAMDDFYADCAARLAAHLDAGRDVVVLAEGDPLFYGSYMHMHKRL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ +VPGVTSVSAA+A + PL D++L+VLPGTLP L RL DAA V+KL Sbjct 123 ADRYPCEVVPGVTSVSAAAAVLGRPLCERDEILTVLPGTLPPDVLAERLRSTDAAAVMKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRAL 244 GR++ NVREA +G +A+YVERA+T QR ADVD SVPYFSLA+LP A Sbjct 183 GRTFGNVREAFELAGRADEAWYVERATTDAQRTARLADVDPDSVPYFSLALLPSPMNTAF 242 Query 245 LT--------GTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 G+V VVGLGP +WMTP+ R LA A D+IGY Y+DR+ R QR+H Sbjct 243 QAPAVAEATPGSVTVVGLGPAGPEWMTPEVRAALATADDVIGYGPYVDRLPDRARQRKHG 302 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAE--QWPGVRVRVIPAM 354 SDN E RA A LA +G V VVSSGDPGVFAMA+AV E A ++ + VRV+P M Sbjct 303 SDNKVESERAAFALDLARKGSRVVVVSSGDPGVFAMASAVTEVAAEPEYADLTVRVLPGM 362 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAAQAVASR GAPLGHDY V+SLSDRLKPWDVIAARL AAAAADL +AIYNPAS +RTWQ Sbjct 363 TAAQAVASRAGAPLGHDYCVLSLSDRLKPWDVIAARLGAAAAADLAIAIYNPASKSRTWQ 422 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 V A R+LLL HR PG PVVIGR+ V G +E V + L +L+PA++DMRCLL++GSSQ Sbjct 423 VAATRDLLLEHRSPGTPVVIGRD----VGGASESVTITTLGELDPAQVDMRCLLLIGSSQ 478 Query 475 TRWYSVDSQDRVFTPRRYPEAGRATATKSSR 505 T+ + VFTPRRYP++ + K+ R Sbjct 479 TQSVDRPAGPLVFTPRRYPDSAQELVNKAGR 509 Score = 48.1 bits (113), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/182 (30%), Positives = 86/182 (48%), Gaps = 34/182 (18%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGY------RGYLDRVE---VRDGQRRH 295 ++G + VGLGPGD + +T ++ R + AA D+I + R V +RDGQ Sbjct 1 MSGRLWGVGLGPGDPELVTVKAARLIGAA-DVIAFHSARHGRSIARSVAAPYLRDGQVEE 59 Query 296 ------PSDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATAV 336 ++ TD P ARLA L D GR V V++ GDP + + Sbjct 60 HLVYPLTTETTDHPGGYQGAMDDFYADCAARLAAHL-DAGRDVVVLAEGDPLFYGSYMHM 118 Query 337 LEE-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAA 395 + A+++P V+P +T+ A A+ +G PL ++++ P DV+A RL + Sbjct 119 HKRLADRYP---CEVVPGVTSVSAAAAVLGRPLCERDEILTVLPGTLPPDVLAERLRSTD 175 Query 396 AA 397 AA Sbjct 176 AA 177 >gi|290955548|ref|YP_003486730.1| bifunctional protein S-adenosyl-L-methionine-precorrin-2 methyl transferase\precorrin-3 methylase [Streptomyces scabiei 87.22] gi|260645074|emb|CBG68160.1| Probable bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase [Streptomyces scabiei 87.22] Length=496 Score = 566 bits (1458), Expect = 4e-159, Method: Compositional matrix adjust. Identities = 310/497 (63%), Positives = 370/497 (75%), Gaps = 11/497 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A VI EADV+AYHSA HG SIAR IA +LR +EE L+ Sbjct 3 GKLYGVGLGPGDPSLMTVRAVEVISEADVIAYHSARHGRSIARSIAAKHLRDDHIEERLM 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YP+TTE T+HPGGY GA+EDFY +A+ R+A HLDAGR VA+LAEGDPLFY SYMH+H RL Sbjct 63 YPLTTETTDHPGGYKGAMEDFYEEASARLAAHLDAGRTVAVLAEGDPLFYGSYMHMHKRL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R++ ++PGVTSVSAA+A + TPLV G++VL++LPGTLP ELT RLA D AVV+KL Sbjct 123 VDRYDTEVIPGVTSVSAAAARLGTPLVEGEEVLTILPGTLPEEELTARLAATDVAVVMKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGG----R 240 GR++ VR AL++SG L +A YVERA+ G+R+ ADVD SVPYFS+A+LP R Sbjct 183 GRTFAKVRGALASSGRLAEAHYVERATMPGERIGELADVDPESVPYFSVAVLPSQVDAER 242 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 A G V VVG GP W+TP++R LAAA DL+GY YLDRV R GQ RH SDN Sbjct 243 PAARERGEVVVVGTGPAGPLWLTPETRGALAAADDLVGYTTYLDRVPRRAGQVRHGSDNR 302 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEA--EQWPGVRVRVIPAMTAAQ 358 E RA A LA +GR VAVVS GDPGVFAMATAVLE A E++ V VRV+P +TAA Sbjct 303 VESERAEFALDLARRGRRVAVVSGGDPGVFAMATAVLEVAAQEEYADVPVRVLPGVTAAN 362 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 A A+R GAPLGHDYA +SLSDRLKPW+VIA RL AAA+ADLVLA+YNP S +RTWQVG Sbjct 363 AAAARAGAPLGHDYATLSLSDRLKPWEVIAERLRAAASADLVLALYNPGSRSRTWQVGKA 422 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 RELLL HR P PVV+ R+ V G E VR+V LADL+PAE+DMR +L+VGSSQTR Sbjct 423 RELLLEHRAPDTPVVVARD----VGGSGERVRIVTLADLDPAEVDMRTILLVGSSQTRVV 478 Query 479 SV-DSQDRVFTPRRYPE 494 D + V+TPRRYPE Sbjct 479 RRGDGEQIVWTPRRYPE 495 Score = 46.6 bits (109), Expect = 0.010, Method: Compositional matrix adjust. Identities = 52/185 (29%), Positives = 80/185 (44%), Gaps = 40/185 (21%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYL----------------DRVEV 288 ++G + VGLGPGD MT ++ E+ + D+I Y D +E Sbjct 1 MSGKLYGVGLGPGDPSLMTVRA-VEVISEADVIAYHSARHGRSIARSIAAKHLRDDHIEE 59 Query 289 R------------DGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFA----M 332 R G + ++ E A ARLA L D GR VAV++ GDP + M Sbjct 60 RLMYPLTTETTDHPGGYKGAMEDFYEEASARLAAHL-DAGRTVAVLAEGDPLFYGSYMHM 118 Query 333 ATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLT 392 +++ + VIP +T+ A A+R+G PL V+++ P + + ARL Sbjct 119 HKRLVDRYD------TEVIPGVTSVSAAAARLGTPLVEGEEVLTILPGTLPEEELTARLA 172 Query 393 AAAAA 397 A A Sbjct 173 ATDVA 177 >gi|182437615|ref|YP_001825334.1| putative precorrin methylase [Streptomyces griseus subsp. griseus NBRC 13350] gi|178466131|dbj|BAG20651.1| putative precorrin methylase [Streptomyces griseus subsp. griseus NBRC 13350] Length=504 Score = 565 bits (1456), Expect = 7e-159, Method: Compositional matrix adjust. Identities = 312/500 (63%), Positives = 370/500 (74%), Gaps = 13/500 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP+L+T++A R IG+ADV+AYHSA HG SIAR IA +LRP +EE LV Sbjct 9 GRLYGVGLGPGDPDLMTLRAVRAIGDADVIAYHSARHGRSIARSIAAAHLRPDHIEEALV 68 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GALE+FY +A R+ATHLDAGR VA+LAEGDP+FY SYMH+H RL Sbjct 69 YPVTTETTDHPGGYRGALEEFYEEAAARLATHLDAGRTVAVLAEGDPMFYGSYMHMHKRL 128 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ ++PGVTSVSAA+A + TPLV G+++L++LPGTLP ELT RLA D AVV+KL Sbjct 129 ADRYPTEVIPGVTSVSAAAARLGTPLVEGEEILTILPGTLPEEELTARLAATDTAVVMKL 188 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR++ VR A ASG L +A YVERA+ AG+R AD+D SVPYFS+A+LP R Sbjct 189 GRTFPAVRGAFEASGRLPEARYVERATMAGERTGDLADIDPESVPYFSVAVLPSRVDAPR 248 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 +G V VVG GP W+TP++R LAAA +IGY YLDRV VR GQ RH SDN Sbjct 249 PAPSASGEVVVVGTGPAGPLWLTPETRGALAAADAVIGYTTYLDRVPVRPGQARHGSDNK 308 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGVRVRVIPAMTAAQ 358 E RA A LA +G VAVVS GDPGVFAMATAVLE A Q + V VRV+P +TAA Sbjct 309 VESERAEFALDLARRGHRVAVVSGGDPGVFAMATAVLEVASQDAYADVPVRVLPGVTAAN 368 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 A A+R GAPLGHDYA ISLSDRLKPW+VIA RL AAA+ADLVLA+YNP S +RTWQVG Sbjct 369 AAAARAGAPLGHDYATISLSDRLKPWEVIAERLRAAASADLVLALYNPGSRSRTWQVGKA 428 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+LLL HR P PVV+ R+V GP E VR V+LAD++PAE+DMR LLIVGSSQTRW Sbjct 429 RDLLLEHRSPDTPVVLARDVGGPA----ESVRTVRLADVDPAEVDMRTLLIVGSSQTRWV 484 Query 479 ---SVDSQDRVFTPRRYPEA 495 + V+TPRRYPEA Sbjct 485 RRGEDGGRGIVWTPRRYPEA 504 >gi|345011368|ref|YP_004813722.1| precorrin-3B C17-methyltransferase [Streptomyces violaceusniger Tu 4113] gi|344037717|gb|AEM83442.1| precorrin-3B C17-methyltransferase [Streptomyces violaceusniger Tu 4113] Length=499 Score = 564 bits (1453), Expect = 1e-158, Method: Compositional matrix adjust. Identities = 322/497 (65%), Positives = 374/497 (76%), Gaps = 10/497 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A VI EADV+AYHSA HG SIAR IAE +LRP +EE LV Sbjct 7 GRLYGVGLGPGDPSLMTVRAVEVIAEADVIAYHSARHGRSIARSIAERHLRPDHIEERLV 66 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GA+++FYADA R+A HLDAGR VA+LAEGDPLFY SYMH+H RL Sbjct 67 YPVTTETTDHPGGYRGAMDEFYADAATRLAAHLDAGRTVAVLAEGDPLFYGSYMHMHKRL 126 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ ++PGVTSVSAA+A + PLV G++VL+VLPGTLP ELT RLA DAA V+KL Sbjct 127 ADRYPTEVIPGVTSVSAAAARLGAPLVEGEEVLTVLPGTLPEEELTARLATTDAAAVMKL 186 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPG---GRR 241 GR++ VR AL SG L DA YVERA+ +R P A+VD SVPYFS+A+LP R Sbjct 187 GRTFPTVRRALERSGRLADARYVERATMDAERTAPLAEVDPESVPYFSMAVLPSRVDAPR 246 Query 242 RALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTD 301 G V VVGLGP W+TP++R ELA A DL+GY YLDRV VR GQRRH SDN Sbjct 247 DESGMGEVVVVGLGPAGPLWLTPEARAELATAQDLVGYSTYLDRVLVRPGQRRHASDNKV 306 Query 302 EPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWP--GVRVRVIPAMTAAQA 359 E RA LA LA +GR VAVVSSGDPGVFAMATAVLE A + P V VR++P MTAA A Sbjct 307 ESVRAELALDLARRGRRVAVVSSGDPGVFAMATAVLEAASEDPYREVPVRIVPGMTAAHA 366 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 A+R GAPLGHDYAVISLSDRLKPW+VIA RL AAAAADLVLA+YNP S +R WQVG R Sbjct 367 AAARAGAPLGHDYAVISLSDRLKPWEVIAERLRAAAAADLVLALYNPGSRSRVWQVGKAR 426 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYS 479 ELLL HR P PVV+GR+ + GP E VR+V+LADL+PA++DMR +L+VGSSQTR Sbjct 427 ELLLEHRAPDTPVVLGRD----IGGPGERVRIVRLADLDPADVDMRTILLVGSSQTRTVR 482 Query 480 V-DSQDRVFTPRRYPEA 495 D D V+TPRRYPEA Sbjct 483 RGDGTDVVWTPRRYPEA 499 Score = 52.0 bits (123), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/181 (32%), Positives = 81/181 (45%), Gaps = 34/181 (18%) Query 246 TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLD-RVEVRDGQRRH--------- 295 TG + VGLGPGD MT ++ E+ A D+I Y R R RH Sbjct 6 TGRLYGVGLGPGDPSLMTVRA-VEVIAEADVIAYHSARHGRSIARSIAERHLRPDHIEER 64 Query 296 -----PSDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATAVL 337 ++ TD P A RLA L D GR VAV++ GDP + + Sbjct 65 LVYPVTTETTDHPGGYRGAMDEFYADAATRLAAHL-DAGRTVAVLAEGDPLFYGSYMHMH 123 Query 338 EE-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAA 396 + A+++P VIP +T+ A A+R+GAPL V+++ P + + ARL A Sbjct 124 KRLADRYP---TEVIPGVTSVSAAAARLGAPLVEGEEVLTVLPGTLPEEELTARLATTDA 180 Query 397 A 397 A Sbjct 181 A 181 >gi|326778269|ref|ZP_08237534.1| precorrin-3B C17-methyltransferase [Streptomyces cf. griseus XylebKG-1] gi|326658602|gb|EGE43448.1| precorrin-3B C17-methyltransferase [Streptomyces griseus XylebKG-1] Length=504 Score = 563 bits (1451), Expect = 2e-158, Method: Compositional matrix adjust. Identities = 311/500 (63%), Positives = 369/500 (74%), Gaps = 13/500 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP+L+T++A R IG+ADV+AYHSA HG SIAR IA +LRP +EE LV Sbjct 9 GRLYGVGLGPGDPDLMTLRAVRAIGDADVIAYHSARHGRSIARSIAAAHLRPDHIEEALV 68 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GALE+FY +A R+ATHLDAGR VA+LAEGDP+FY SYMH+H RL Sbjct 69 YPVTTETTDHPGGYRGALEEFYEEAAARLATHLDAGRTVAVLAEGDPMFYGSYMHMHKRL 128 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ ++PGVTSVSAA+A + TPLV G+++L++LPGTLP ELT RLA D AVV+KL Sbjct 129 ADRYPTEVIPGVTSVSAAAARLGTPLVEGEEILTILPGTLPEEELTARLAATDTAVVMKL 188 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR++ VR A ASG L +A YVERA+ AG+R AD+D SVPYFS+A+LP R Sbjct 189 GRTFPAVRGAFEASGRLPEARYVERATMAGERTGDLADIDPESVPYFSVAVLPSRVDAPR 248 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 +G V VVG GP W+TP++R LAAA ++GY YLDRV VR GQ RH SDN Sbjct 249 PAPSASGEVVVVGTGPAGPLWLTPETRGALAAADAVVGYTTYLDRVPVRPGQARHGSDNK 308 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGVRVRVIPAMTAAQ 358 E RA A LA +G VAVVS GDPGVFAMATAVLE A Q + V VRV+P +TAA Sbjct 309 VESERAEFALDLARRGHRVAVVSGGDPGVFAMATAVLEVASQDDYADVPVRVLPGVTAAN 368 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 A A+R GAPLGHDYA ISLSDRLKPW+VIA RL AAA+ADLVLA+YNP S +RTWQVG Sbjct 369 AAAARAGAPLGHDYATISLSDRLKPWEVIAERLRAAASADLVLALYNPGSRSRTWQVGKA 428 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+LLL HR P PVV+ R+ V GP E VR V LAD++PAE+DMR LLIVGSSQTRW Sbjct 429 RDLLLEHRSPDTPVVLARD----VGGPTESVRTVPLADVDPAEVDMRTLLIVGSSQTRWV 484 Query 479 ---SVDSQDRVFTPRRYPEA 495 + V+TPRRYPEA Sbjct 485 RRGEDGGRGIVWTPRRYPEA 504 >gi|345000992|ref|YP_004803846.1| precorrin-3B C17-methyltransferase [Streptomyces sp. SirexAA-E] gi|344316618|gb|AEN11306.1| precorrin-3B C17-methyltransferase [Streptomyces sp. SirexAA-E] Length=505 Score = 563 bits (1451), Expect = 2e-158, Method: Compositional matrix adjust. Identities = 310/498 (63%), Positives = 371/498 (75%), Gaps = 12/498 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A +VI EADVVAYHSA HG SIAR IA ++RP +EE LV Sbjct 11 GRLYGVGLGPGDPALMTVRAVQVIAEADVVAYHSARHGRSIARSIAARHIRPDHIEEALV 70 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GAL++FYA+A R+A HLDAGR VA+LAEGDPLFY SY H+H RL Sbjct 71 YPVTTETTDHPGGYRGALDEFYAEAAARLAVHLDAGRTVAVLAEGDPLFYGSYQHMHKRL 130 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ ++PGVTSVSAA+A + TPLV G++VL++LPGTL ELT RLA D+AVV+KL Sbjct 131 ADRYATEVIPGVTSVSAAAARLGTPLVEGEEVLTILPGTLAEEELTARLAATDSAVVMKL 190 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPG-----G 239 GR++ VR A ASG L +A YVERA+ AG+R A+ D SVPYF++A+LP Sbjct 191 GRTFPAVRRAFEASGRLPEARYVERATMAGERTGDLAETDPDSVPYFAVAVLPSRIDAPR 250 Query 240 RRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 RA G V VVG GP W+TP++R LAAA DL+GY YLDRV VR GQ+RH SDN Sbjct 251 PARAEAPGEVVVVGTGPAGPLWLTPETRGALAAADDLVGYTTYLDRVPVRPGQQRHGSDN 310 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGVRVRVIPAMTAA 357 E RA A LA +GR VAVVS GDPGVFAMATAVLE A Q + V VRV+P +TAA Sbjct 311 KVESERAEFALDLARRGRRVAVVSGGDPGVFAMATAVLEVASQDAYTDVPVRVLPGVTAA 370 Query 358 QAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGA 417 A A+R GAPLGHDYA +SLSDRLKPW+VIA RL AAA+ADLV+A+YNP S +RTWQVG Sbjct 371 NAAAARAGAPLGHDYATLSLSDRLKPWEVIAERLRAAASADLVIALYNPGSRSRTWQVGK 430 Query 418 MRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRW 477 R+LLL HR P PVV+GR+V GP E VR V+LADL+PAE+DMR +L+VGSSQTRW Sbjct 431 ARDLLLEHRSPDTPVVLGRDVGGPA----ESVRTVRLADLDPAEVDMRTVLVVGSSQTRW 486 Query 478 YSVDSQDR-VFTPRRYPE 494 ++ V+TPRRYPE Sbjct 487 VRRGGGEQIVWTPRRYPE 504 >gi|320009606|gb|ADW04456.1| precorrin-3B C17-methyltransferase [Streptomyces flavogriseus ATCC 33331] Length=505 Score = 561 bits (1446), Expect = 9e-158, Method: Compositional matrix adjust. Identities = 309/504 (62%), Positives = 368/504 (74%), Gaps = 24/504 (4%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A ++IGEADVVAYHSA HG SIAR IA Y+R +EE LV Sbjct 11 GRLYGVGLGPGDPALMTVRAVQIIGEADVVAYHSARHGRSIARSIAAQYIRADHIEEALV 70 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GAL++FYA+A R+A HLDAGR VA+LAEGDPLFY SY H+H RL Sbjct 71 YPVTTETTDHPGGYRGALDEFYAEAAARLAVHLDAGRTVAVLAEGDPLFYGSYQHMHKRL 130 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ ++PGVTSVSAA+A + TPLV ++VL++LPGTLP ELT RLA D+AVV+KL Sbjct 131 ADRYETEVIPGVTSVSAAAARLGTPLVEAEEVLTILPGTLPEEELTARLAATDSAVVMKL 190 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPG------ 238 GR++ VR A ASG L +A YVERA+ AG+R AD D +VPYF++A+LP Sbjct 191 GRTFPAVRRAFEASGRLPEARYVERATMAGERTGDLADTDADTVPYFAVAVLPSRIDAPR 250 Query 239 -----GRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQR 293 GR G V VVG GP W+TP++R LAAA D++GY YLDRV VR GQR Sbjct 251 PEPVPGR------GEVVVVGTGPAGPLWLTPETRGALAAADDVVGYTTYLDRVPVRPGQR 304 Query 294 RHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGVRVRVI 351 RH SDN E RA A LA +G VAVVS GDPGVFAMATAVLE A Q + V VRV+ Sbjct 305 RHGSDNKVESERAEFALDLARRGHRVAVVSGGDPGVFAMATAVLEVASQDTYADVAVRVL 364 Query 352 PAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTR 411 P +TAA A A+R GAPLGHDYA ISLSDRLKPW+V+A RL AAA ADLV+A+YNP S +R Sbjct 365 PGVTAANAAAARAGAPLGHDYATISLSDRLKPWEVVAGRLRAAATADLVMALYNPGSRSR 424 Query 412 TWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVG 471 TWQVG R+LLL HR P PVV+GR+V GP E VR V+L DL+PAE+DMR +LIVG Sbjct 425 TWQVGKARDLLLEHRSPDTPVVLGRDVGGPA----ESVRTVRLGDLDPAEVDMRTILIVG 480 Query 472 SSQTRW-YSVDSQDRVFTPRRYPE 494 SSQTRW + + V+TPRRYPE Sbjct 481 SSQTRWVHRGGDRQIVWTPRRYPE 504 >gi|302529244|ref|ZP_07281586.1| precorrin-2 C20-methyltransferase [Streptomyces sp. AA4] gi|302438139|gb|EFL09955.1| precorrin-2 C20-methyltransferase [Streptomyces sp. AA4] Length=505 Score = 560 bits (1442), Expect = 3e-157, Method: Compositional matrix adjust. Identities = 308/506 (61%), Positives = 368/506 (73%), Gaps = 22/506 (4%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDPEL+TVKAAR+IGEADV+AYHSA HG SIAR +AEPYLR GQLEE LV Sbjct 3 GRLYGVGLGPGDPELMTVKAARLIGEADVIAYHSARHGRSIARSVAEPYLREGQLEERLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GA+ DFY + +++A HLDAGR+V LL EGDP FY SYM++H RL Sbjct 63 YPVTTETTDHPGGYEGAIADFYELSAKKLAEHLDAGRDVVLLCEGDPFFYGSYMYMHERL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 RF A +VPGVTSVSAA++ + PLV D+VL+VLPGTLP EL RRLAD +AA V+KL Sbjct 123 AGRFEAEVVPGVTSVSAAASVLGRPLVQRDEVLTVLPGTLPAPELARRLADTEAAAVLKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRAL 244 GR++ +VRE L+ SG L DA+Y+ERA+ QRV P ADVD SVPYFSLA+LP ++ Sbjct 183 GRTFGSVREGLAESGKLDDAWYIERATWGQQRVEPFADVDPESVPYFSLALLPSPAYKSR 242 Query 245 LTG---------------TVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVR 289 + G V VVGLGP +W+TP++ ELAAA ++GY Y+ RV R Sbjct 243 VDGEPAAAPSAPVSAGGGEVVVVGLGPAGPEWLTPEASAELAAADHIVGYGPYVARVPQR 302 Query 290 DGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEE--AEQWPGVR 347 GQ+RH S N E RA A LA G VAVVSSGDPGVFAMA+AVLE+ A G R Sbjct 303 AGQQRHASGNRVEADRAVEALQLAATGARVAVVSSGDPGVFAMASAVLEQVSAGNGHGAR 362 Query 348 VRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPA 407 VR++P +TAAQA ASRVGAPLGHDY V+SLSDRLKPW++I RL AA AADLVLA+YNPA Sbjct 363 VRIVPGVTAAQAAASRVGAPLGHDYCVLSLSDRLKPWEIIERRLDAAGAADLVLALYNPA 422 Query 408 SVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCL 467 S TR Q+ RE+LL HRDP PVV+ R+ V GP EDVRV L +L+PA +DMRCL Sbjct 423 SRTRVTQLANAREVLLRHRDPATPVVVARD----VGGPEEDVRVTTLGELDPATVDMRCL 478 Query 468 LIVGSSQT-RWYSVDSQDRVFTPRRY 492 LIVGSS+T D + V+TPR Y Sbjct 479 LIVGSSRTVAEEGPDGRSIVWTPRSY 504 Score = 39.7 bits (91), Expect = 1.1, Method: Compositional matrix adjust. Identities = 48/181 (27%), Positives = 74/181 (41%), Gaps = 32/181 (17%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRG---------YLDRVEVRDGQRRH 295 +TG + VGLGPGD + MT ++ R L D+I Y + +R+GQ Sbjct 1 MTGRLYGVGLGPGDPELMTVKAAR-LIGEADVIAYHSARHGRSIARSVAEPYLREGQLEE 59 Query 296 ------PSDNTDEPA------------RARLACSLADQGRAVAVVSSGDPGVFAMATAVL 337 ++ TD P A+ D GR V ++ GDP + + + Sbjct 60 RLVYPVTTETTDHPGGYEGAIADFYELSAKKLAEHLDAGRDVVLLCEGDPFFYG---SYM 116 Query 338 EEAEQWPG-VRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAA 396 E+ G V+P +T+ A AS +G PL V+++ P +A RL A Sbjct 117 YMHERLAGRFEAEVVPGVTSVSAAASVLGRPLVQRDEVLTVLPGTLPAPELARRLADTEA 176 Query 397 A 397 A Sbjct 177 A 177 >gi|333919703|ref|YP_004493284.1| Precorrin-3B C17-methyltransferase [Amycolicicoccus subflavus DQS3-9A1] gi|333481924|gb|AEF40484.1| Precorrin-3B C17-methyltransferase [Amycolicicoccus subflavus DQS3-9A1] Length=500 Score = 559 bits (1440), Expect = 5e-157, Method: Compositional matrix adjust. Identities = 316/494 (64%), Positives = 372/494 (76%), Gaps = 9/494 (1%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+G+GLGPGDPELVTVKAAR+I EADVVAYHSA HGHSIARG+A PYLR GQ+EE LV Sbjct 3 GKLFGIGLGPGDPELVTVKAARIIAEADVVAYHSARHGHSIARGVAAPYLRDGQVEEKLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YP+TTE T+HP GY GA+++FY ++ R+A HLDAGRNVALLAEGDPLFYSSYMH+H RL Sbjct 63 YPLTTETTDHPRGYQGAIDEFYEESAARLAAHLDAGRNVALLAEGDPLFYSSYMHMHKRL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 + + IVPGVTSV+AASAA TPLV D+VL+V+PGTLPV EL RLA++DA ++KL Sbjct 123 SGTYQTEIVPGVTSVAAASAATQTPLVERDEVLTVVPGTLPVAELADRLANSDAVAIMKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRAL 244 GR++ VREAL SG L +A YVERAS + QRVLP DV+ VPYFS+A++P A Sbjct 183 GRTFGAVREALEKSGRLEEAVYVERASWSAQRVLPLKDVEPDEVPYFSVALIPSPLNAAA 242 Query 245 ---LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNTD 301 G V VVGLGPGD +W T + RREL A TDL+GY YL RV QR HPSDN Sbjct 243 PHSSRGEVVVVGLGPGDPEWTTQEVRRELRAVTDLVGYGPYLARVAPNAWQRHHPSDNRV 302 Query 302 EPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAE--QWPGVRVRVIPAMTAAQA 359 E RA A LA G VAVVSSGDPGVFAMATAVLE A ++ + VRV+P +TAA A Sbjct 303 EEERAAFALDLARGGARVAVVSSGDPGVFAMATAVLEVASRAEYADIPVRVVPGLTAANA 362 Query 360 VASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAMR 419 VA+R GAPLGHDYAVISLSDRLKPWD++ RLTAAA ADL +AIYNPAS +RTWQV AM+ Sbjct 363 VAARAGAPLGHDYAVISLSDRLKPWDIVEERLTAAAKADLAIAIYNPASKSRTWQVQAMK 422 Query 420 ELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYS 479 E LL ++ P PVVIGR V PNEDV++V L L+PA++DMRCLLI+GSSQT Sbjct 423 ETLLQYKSPETPVVIGRA----VGSPNEDVKLVPLGSLDPADVDMRCLLIIGSSQTVMAE 478 Query 480 VDSQDRVFTPRRYP 493 + V+TPRRYP Sbjct 479 RSASPVVYTPRRYP 492 Score = 37.0 bits (84), Expect = 8.9, Method: Compositional matrix adjust. Identities = 38/120 (32%), Positives = 56/120 (47%), Gaps = 40/120 (33%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGY----------RG----YLDRVEVRD 290 +TG + +GLGPGD + +T ++ R +A A D++ Y RG YL RD Sbjct 1 MTGKLFGIGLGPGDPELVTVKAARIIAEA-DVVAYHSARHGHSIARGVAAPYL-----RD 54 Query 291 GQRRHP------SDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFA 331 GQ ++ TD P + ARLA L D GR VA+++ GDP ++ Sbjct 55 GQVEEKLVYPLTTETTDHPRGYQGAIDEFYEESAARLAAHL-DAGRNVALLAEGDPLFYS 113 >gi|300788890|ref|YP_003769181.1| precorrin-2 C20-methyltransferase [Amycolatopsis mediterranei U32] gi|299798404|gb|ADJ48779.1| precorrin-2 C20-methyltransferase [Amycolatopsis mediterranei U32] gi|340530514|gb|AEK45719.1| precorrin-2 C20-methyltransferase [Amycolatopsis mediterranei S699] Length=495 Score = 558 bits (1437), Expect = 1e-156, Method: Compositional matrix adjust. Identities = 304/501 (61%), Positives = 362/501 (73%), Gaps = 21/501 (4%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 GTL+GVGLGPGDPEL+TVKAAR+I EA V+AYH A HG SIAR +AEPYLR GQLEE LV Sbjct 3 GTLYGVGLGPGDPELMTVKAARLISEASVIAYHCARHGRSIARSVAEPYLREGQLEEKLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GA+ DFY + +R+A HLDAGR+V LL EGDP FY SYM++H RL Sbjct 63 YPVTTETTDHPGGYEGAIADFYELSAKRLAEHLDAGRDVVLLCEGDPFFYGSYMYMHERL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 RF AV+VPGVTSVSAAS+ PLV D+VL+VLPGTLP EL RRLAD DAA V+KL Sbjct 123 AGRFEAVVVPGVTSVSAASSVFGRPLVQRDEVLTVLPGTLPAPELARRLADTDAAAVLKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPG------ 238 GR++ +VREA + +G L DA YVERA+ QR+ P A VD ++VPYFSLA+LP Sbjct 183 GRTFSSVREAFAEAGKLDDAVYVERATWGQQRIEPLASVDPSTVPYFSLALLPSPAYASR 242 Query 239 -----GRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQR 293 G V VVGLGP +W+TP++ EL AA ++GY Y+ RV + GQ+ Sbjct 243 QSSPAPAASPSSVGEVVVVGLGPAGPEWLTPEAASELDAAEHIVGYGPYVARVPQKAGQQ 302 Query 294 RHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEE--AEQWPGVRVRVI 351 RH S N E RAR A SLA G VAVVSSGDPGVFAMA+AVLE+ A GVRVR++ Sbjct 303 RHASGNRVEADRAREALSLAASGSRVAVVSSGDPGVFAMASAVLEQVSAGHGAGVRVRIV 362 Query 352 PAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTR 411 P +TAAQA ASRVGAPLGHDY V+SLSDRLKPW++I RL AA AADLVLA+YNPAS TR Sbjct 363 PGVTAAQAAASRVGAPLGHDYCVLSLSDRLKPWEIIEKRLDAAGAADLVLALYNPASRTR 422 Query 412 TWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVG 471 T Q+ R +LL HR P PVV+ R+ V GP ED+R+ L +L+P+ +DMRCLLIVG Sbjct 423 TTQLADARAVLLRHRAPSTPVVVARD----VGGPEEDIRITTLGELDPSTVDMRCLLIVG 478 Query 472 SSQTRWYSVDSQDRVFTPRRY 492 SS+TR V+TPR Y Sbjct 479 SSRTR----SDNGIVWTPRSY 495 Score = 39.7 bits (91), Expect = 1.3, Method: Compositional matrix adjust. Identities = 53/182 (30%), Positives = 81/182 (45%), Gaps = 34/182 (18%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGY------RGYLDRVE---VRDGQRRH 295 +TGT+ VGLGPGD + MT ++ R ++ A+ +I Y R V +R+GQ Sbjct 1 MTGTLYGVGLGPGDPELMTVKAARLISEAS-VIAYHCARHGRSIARSVAEPYLREGQLEE 59 Query 296 P------SDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATAV 336 ++ TD P + RLA L D GR V ++ GDP + + Sbjct 60 KLVYPVTTETTDHPGGYEGAIADFYELSAKRLAEHL-DAGRDVVLLCEGDPFFYGSYMYM 118 Query 337 LEE-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAA 395 E A ++ V V+P +T+ A +S G PL V+++ P +A RL Sbjct 119 HERLAGRFEAV---VVPGVTSVSAASSVFGRPLVQRDEVLTVLPGTLPAPELARRLADTD 175 Query 396 AA 397 AA Sbjct 176 AA 177 >gi|308403445|ref|ZP_07493819.2| precorrin-2 C(20)-methyltransferase [Mycobacterium tuberculosis SUMu012] gi|308365717|gb|EFP54568.1| precorrin-2 C(20)-methyltransferase [Mycobacterium tuberculosis SUMu012] Length=308 Score = 552 bits (1423), Expect = 4e-155, Method: Compositional matrix adjust. Identities = 280/280 (100%), Positives = 280/280 (100%), Gaps = 0/280 (0%) Query 1 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 60 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE Sbjct 29 MSARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLE 88 Query 61 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 120 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL Sbjct 89 EHLVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHL 148 Query 121 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 180 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV Sbjct 149 HTRLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAV 208 Query 181 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 240 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR Sbjct 209 VVKLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR 268 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYR 280 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYR Sbjct 269 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYR 308 >gi|256375915|ref|YP_003099575.1| precorrin-3B C17-methyltransferase [Actinosynnema mirum DSM 43827] gi|255920218|gb|ACU35729.1| precorrin-3B C17-methyltransferase [Actinosynnema mirum DSM 43827] Length=516 Score = 551 bits (1419), Expect = 1e-154, Method: Compositional matrix adjust. Identities = 314/523 (61%), Positives = 370/523 (71%), Gaps = 45/523 (8%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVG+GPGDPELVTVKAAR+IGEADVV +HSA HG S+AR AEPYLR GQ+EE LV Sbjct 3 GRLYGVGVGPGDPELVTVKAARLIGEADVVVFHSARHGRSVARRTAEPYLRAGQVEEQLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE ++ Y G ++ FYA+ ER+A HLDAGR V +LA GDPLFY SYMHLH RL Sbjct 63 YPVTTEDSDD---YQGEIDAFYAECAERLAAHLDAGRTVVVLAAGDPLFYGSYMHLHKRL 119 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ A +VPGVTSVSAASA + PLV D+VL+VLPGTLPV EL RLA D V+KL Sbjct 120 AHRYPAEVVPGVTSVSAASAVLGAPLVERDEVLTVLPGTLPVDELAGRLAGGDPVAVMKL 179 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGRRRAL 244 GR++ NVREAL +G L +A+YVERA+T G+R ++VD VPYFS+A+LP R A Sbjct 180 GRTFPNVREALERAGRLDEAWYVERATTRGERTAKLSEVDPDEVPYFSVAVLP-SRAGAP 238 Query 245 LT----------------------------------GTVAVVGLGPGDSDWMTPQSRREL 270 ++ G V VVGLGP +W+TPQ+R L Sbjct 239 VSAAPGAPTAPAASTTPGVSGVDGSDGVEPLADRGPGEVVVVGLGPAGPEWLTPQAREAL 298 Query 271 AAATDLIGYRGYLDRVEVRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVF 330 AA DL+GY YL+RV +R+H SDN E RA A LA +GR VAVVSSGDPGVF Sbjct 299 EAADDLVGYVTYLNRVPDSPRRRKHASDNKVEAERAAFALELAGRGRRVAVVSSGDPGVF 358 Query 331 AMATAVLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAAR 390 AMA AVLE AE +P V VRV+P MTAA AVASRVGAPLGHDY V+SLSDRLKPW+VIA R Sbjct 359 AMAAAVLEVAEGYPNVPVRVLPGMTAAHAVASRVGAPLGHDYCVVSLSDRLKPWEVIAER 418 Query 391 LTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVR 450 L AAA ADLVLA+YNPAS +RTWQV AMR+LLL HR P PVV+GR+ V GP E VR Sbjct 419 LAAAARADLVLALYNPASRSRTWQVAAMRDLLLEHRSPDTPVVVGRD----VGGPQESVR 474 Query 451 VVKLADLNPAEIDMRCLLIVGSSQTRWYSVDSQDRVFTPRRYP 493 V++LADL+PA +DMRCLL++GSSQTR V +VFTPR YP Sbjct 475 VLRLADLDPATVDMRCLLLIGSSQTR---VSPSGKVFTPRTYP 514 >gi|239989004|ref|ZP_04709668.1| putative precorrin methylase [Streptomyces roseosporus NRRL 11379] gi|291446001|ref|ZP_06585391.1| precorrin-3B C17-methyltransferase [Streptomyces roseosporus NRRL 15998] gi|291348948|gb|EFE75852.1| precorrin-3B C17-methyltransferase [Streptomyces roseosporus NRRL 15998] Length=505 Score = 548 bits (1411), Expect = 1e-153, Method: Compositional matrix adjust. Identities = 310/500 (62%), Positives = 366/500 (74%), Gaps = 13/500 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+T++A + IGEADVVAYHSA HG SIAR IA +LRP +EE LV Sbjct 10 GRLYGVGLGPGDPNLMTLRAVQAIGEADVVAYHSARHGRSIARSIAAAHLRPDHIEEALV 69 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GALE+FY A R+A HLDAGR VA+LAEGDP+FY SYMH+H RL Sbjct 70 YPVTTETTDHPGGYRGALEEFYEAAAARLAAHLDAGRTVAVLAEGDPMFYGSYMHMHKRL 129 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ ++PGVTSVSAA+A + TPLV G+++L++LPGTLP ELT RLA D AVV+KL Sbjct 130 ADRYATEVIPGVTSVSAAAARLGTPLVEGEEILTILPGTLPEEELTARLAATDTAVVMKL 189 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR++ VR A ASG L +A YVERA+ AG+R AD++ SVPYFS+A+LP R Sbjct 190 GRTFPAVRGAFEASGRLPEARYVERATMAGERTGELADIEPESVPYFSVAVLPSRIDAAR 249 Query 241 RRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDNT 300 G V VVG GP W+TP++R LAAA L+GY YLDRV VR GQ RH SDN Sbjct 250 PSGKAAGEVVVVGTGPAGPLWLTPETRGALAAADALVGYTTYLDRVPVRPGQARHGSDNK 309 Query 301 DEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGVRVRVIPAMTAAQ 358 E RA A LA +G VAVVS GDPGVFAMATAVLE A Q + + VRV+P +TAA Sbjct 310 VESERAEFALDLARRGHRVAVVSGGDPGVFAMATAVLEVASQDAYADIPVRVLPGVTAAN 369 Query 359 AVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGAM 418 A A+R GAPLGHDYA ISLSDRLKPW+VIA RL AAA+ADLVLA+YNP S +RTWQVG Sbjct 370 AAAARAGAPLGHDYATISLSDRLKPWEVIAERLRAAASADLVLALYNPGSKSRTWQVGQA 429 Query 419 RELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWY 478 R+LLL HR P PVV+ R+ V GP E VR V+LAD++PAE+DMR LLIVGSSQTRW Sbjct 430 RDLLLEHRSPDTPVVLARD----VGGPTESVRTVRLADVDPAEVDMRTLLIVGSSQTRWV 485 Query 479 SVDS---QDRVFTPRRYPEA 495 + V+TPRRYPEA Sbjct 486 KRGEDGGRGIVWTPRRYPEA 505 >gi|271966894|ref|YP_003341090.1| precorrin-3B methylase-like protein [Streptosporangium roseum DSM 43021] gi|270510069|gb|ACZ88347.1| Precorrin-3B methylase-like protein [Streptosporangium roseum DSM 43021] Length=509 Score = 548 bits (1411), Expect = 1e-153, Method: Compositional matrix adjust. Identities = 308/508 (61%), Positives = 369/508 (73%), Gaps = 21/508 (4%) Query 3 ARGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEH 62 A G LWGVGLGPGDPELVTVKAAR++GEADV+A+HSA HG SIAR +A PYLR GQ+EE Sbjct 5 ATGRLWGVGLGPGDPELVTVKAARLLGEADVIAFHSARHGRSIARSVAAPYLREGQIEEA 64 Query 63 LVYPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHT 122 L+YP+TTE T+HPGGY GA++DFYA+ R+A HLDAGR+V +L EGDPLFY SYMH+H Sbjct 65 LIYPLTTETTDHPGGYQGAIDDFYAECALRLAAHLDAGRDVVVLCEGDPLFYGSYMHMHK 124 Query 123 RLTRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVV 182 RL+ R+ +VPGVTSVS A+A + PLV D+ L+VLPGTLP L RLA AD+A ++ Sbjct 125 RLSHRYVTEVVPGVTSVSGAAAVLGRPLVERDETLTVLPGTLPAEVLAERLAAADSAAIL 184 Query 183 KLGRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----- 237 KLGR++ VR+AL +G L +A+YVERA+T GQR+ P A+VD SVPYFSLA++P Sbjct 185 KLGRTFTKVRDALDRAGRLDEAWYVERATTGGQRLAPLAEVDPDSVPYFSLALIPSPVNA 244 Query 238 ---GGRRR------ALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEV 288 G R A G V VVGLGP W+TP+++ LA A +L+GY YLDRV Sbjct 245 AQAGPVREAEPAIPAGGPGEVVVVGLGPAGRPWLTPEAQDALAGADELVGYGPYLDRVPP 304 Query 289 RDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGV 346 QRRHP+DN E RA A LA G VAVVSSGDPGVFAMA+AVLE A + + V Sbjct 305 NPRQRRHPTDNRVEAERAAHALELAAAGSRVAVVSSGDPGVFAMASAVLEVACEPRFADV 364 Query 347 RVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNP 406 VRV+P +TAA AVASR GAPLGHDY V+SLSD LKPW+V+A R+TAAA ADLVLAIYNP Sbjct 365 PVRVLPGLTAAHAVASRAGAPLGHDYCVLSLSDLLKPWEVVAGRITAAAKADLVLAIYNP 424 Query 407 ASVTRTWQVGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRC 466 AS +RTWQV A R+LLL HR P PVVIGR+ V G E + V LA+L+PA +DMRC Sbjct 425 ASKSRTWQVAAARDLLLEHRAPETPVVIGRD----VGGAGESMTVTTLAELDPALVDMRC 480 Query 467 LLIVGSSQTRWYSV-DSQDRVFTPRRYP 493 LL+VGSS TR D VFTPRRYP Sbjct 481 LLLVGSSTTRAVKRGDGGQVVFTPRRYP 508 Score = 37.7 bits (86), Expect = 5.1, Method: Compositional matrix adjust. Identities = 50/185 (28%), Positives = 79/185 (43%), Gaps = 32/185 (17%) Query 244 LLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGY------RGYLDRVE---VRDGQRR 294 + TG + VGLGPGD + +T ++ R L A D+I + R V +R+GQ Sbjct 4 MATGRLWGVGLGPGDPELVTVKAARLLGEA-DVIAFHSARHGRSIARSVAAPYLREGQIE 62 Query 295 H------PSDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATA 335 ++ TD P RLA L D GR V V+ GDP + Sbjct 63 EALIYPLTTETTDHPGGYQGAIDDFYAECALRLAAHL-DAGRDVVVLCEGDPLFYGSYMH 121 Query 336 VLEEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAA 395 + + V+P +T+ A+ +G PL +++ P +V+A RL AA Sbjct 122 MHKRLSHR--YVTEVVPGVTSVSGAAAVLGRPLVERDETLTVLPGTLPAEVLAERLAAAD 179 Query 396 AADLV 400 +A ++ Sbjct 180 SAAIL 184 >gi|318059041|ref|ZP_07977764.1| bifunctional protein S-adenosyl-L-methionine-precorrin-2 methyl transferase\precorrin-3 methylase [Streptomyces sp. SA3_actG] Length=496 Score = 546 bits (1408), Expect = 3e-153, Method: Compositional matrix adjust. Identities = 309/497 (63%), Positives = 367/497 (74%), Gaps = 12/497 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A VIGEADV+AYHSA HG SIARGIAE YLR +EE LV Sbjct 3 GKLYGVGLGPGDPSLLTVRAVEVIGEADVIAYHSARHGRSIARGIAERYLREDHVEELLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GALE+FY +A R+A HLDAGR VA+LAEGDP FY SY H+H RL Sbjct 63 YPVTTETTDHPGGYRGALEEFYEEAAARLAAHLDAGRTVAVLAEGDPFFYGSYQHMHKRL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ +VPGVTS +AASA + PLV G++VL+VLPGTLP EL RLA D+AVV+KL Sbjct 123 AHRYETEVVPGVTSFAAASARLGRPLVEGEEVLTVLPGTLPEEELAARLAATDSAVVMKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR++ VR AL +SG L +A YVERA+ G+R ADVD VPYFS+A+LP GR Sbjct 183 GRTFPKVRRALESSGRLDEARYVERATMDGERTAALADVDAAGVPYFSVAVLPSRVASGR 242 Query 241 RRALL-TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 + G V VVG GP W+TP+SR LAAA DL+GY Y+DRV R GQ RH SDN Sbjct 243 PEPVAGRGEVVVVGTGPAGPLWLTPESRGALAAADDLVGYATYIDRVPERPGQSRHASDN 302 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEA--EQWPGVRVRVIPAMTAA 357 E RA A LA +GR VAVVS GDPGVFAMATAVLE A +++ V VRV+P +TAA Sbjct 303 RVESERAEFALQLAARGRRVAVVSGGDPGVFAMATAVLEVASRKEYADVPVRVLPGVTAA 362 Query 358 QAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGA 417 A A+R GAPLGHDYAV SLSDRLKPW+V+A RL AAA ADLVLA+YNP S +RTWQVGA Sbjct 363 NAAAARAGAPLGHDYAVFSLSDRLKPWEVVARRLRAAAGADLVLALYNPGSGSRTWQVGA 422 Query 418 MRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRW 477 R++LL HR PG PVV+ R+ V G E VR+V+LADL+PAE+DMR +L+VGSS+TR Sbjct 423 ARDVLLEHRAPGTPVVVARD----VGGAGERVRIVRLADLDPAEVDMRTILLVGSSRTRV 478 Query 478 YSV-DSQDRVFTPRRYP 493 D ++ V+TPRRYP Sbjct 479 VRRGDGEEIVWTPRRYP 495 Score = 46.6 bits (109), Expect = 0.009, Method: Compositional matrix adjust. Identities = 53/182 (30%), Positives = 84/182 (47%), Gaps = 34/182 (18%) Query 245 LTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGY----------RGYLDRVEVRDGQRR 294 ++G + VGLGPGD +T ++ E+ D+I Y RG +R D Sbjct 1 MSGKLYGVGLGPGDPSLLTVRA-VEVIGEADVIAYHSARHGRSIARGIAERYLREDHVEE 59 Query 295 ---HP--SDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATAV 336 +P ++ TD P A ARLA L D GR VAV++ GDP + + Sbjct 60 LLVYPVTTETTDHPGGYRGALEEFYEEAAARLAAHL-DAGRTVAVLAEGDPFFYGSYQHM 118 Query 337 LEE-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAA 395 + A ++ V+P +T+ A ++R+G PL V+++ P + +AARL A Sbjct 119 HKRLAHRY---ETEVVPGVTSFAAASARLGRPLVEGEEVLTVLPGTLPEEELAARLAATD 175 Query 396 AA 397 +A Sbjct 176 SA 177 >gi|294813428|ref|ZP_06772071.1| putative precorrin methylase [Streptomyces clavuligerus ATCC 27064] gi|326441860|ref|ZP_08216594.1| bifunctional protein S-adenosyl-L-methionine-precorrin-2 methyl transferase\precorrin-3 methylase [Streptomyces clavuligerus ATCC 27064] gi|294326027|gb|EFG07670.1| putative precorrin methylase [Streptomyces clavuligerus ATCC 27064] Length=502 Score = 542 bits (1397), Expect = 5e-152, Method: Compositional matrix adjust. Identities = 306/499 (62%), Positives = 361/499 (73%), Gaps = 15/499 (3%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A VI +ADV+AYHSA HG SIAR IA ++RP +EE LV Sbjct 8 GRLYGVGLGPGDPSLMTVRAVEVIADADVIAYHSARHGRSIARSIAARHIRPDHVEEALV 67 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GA+EDFY +A R+A HLDAGR VA+LAEGDPLFY SYMH+H RL Sbjct 68 YPVTTETTDHPGGYRGAMEDFYTEAAARLAVHLDAGRTVAVLAEGDPLFYGSYMHMHKRL 127 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ +VPGVTSVS A+A + PLV GD+VL++LPGTLP ELT RLA DAAVV+KL Sbjct 128 ADRYETEVVPGVTSVSGAAARLGAPLVEGDEVLTILPGTLPEEELTARLAATDAAVVMKL 187 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP------- 237 GR++ VR AL SG L DA Y ERA+ G+R ADVD SVPYFS+A+LP Sbjct 188 GRTFPKVRRALERSGRLADARYAERATMDGERTARLADVDAESVPYFSVAVLPSRVGLGG 247 Query 238 -GGRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHP 296 G RA G V VVG GP W+TP+S+ LAAA DL+GY YLDRV VR GQ+RH Sbjct 248 DAGDHRAAEGGEVVVVGTGPAGPLWLTPESKGALAAADDLVGYTTYLDRVPVRPGQQRHG 307 Query 297 SDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQ--WPGVRVRVIPAM 354 SDN E RA A LA +GR+VAVVS GDPGVFAMATAVLE A Q + V VRV+P + Sbjct 308 SDNKVESERAEFALDLARRGRSVAVVSGGDPGVFAMATAVLEVASQPEYADVPVRVLPGV 367 Query 355 TAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQ 414 TAA A A+ GAPLGHDYA +SLSDRLKPW+VIA RL AAA ADLVLA+YNP S +RTWQ Sbjct 368 TAANAAAAAAGAPLGHDYATVSLSDRLKPWEVIAERLRAAATADLVLALYNPGSRSRTWQ 427 Query 415 VGAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQ 474 V RELLL HR P PVV+ R+ V G + VR+V+LA+L P E+DMR +L+VGSS+ Sbjct 428 VAKARELLLEHRAPDTPVVVARD----VGGDGQCVRIVRLAELVPEEVDMRTILLVGSSR 483 Query 475 TRWYSV-DSQDRVFTPRRY 492 TR D + V+TPRRY Sbjct 484 TRVVRRGDGSEVVWTPRRY 502 Score = 48.5 bits (114), Expect = 0.002, Method: Compositional matrix adjust. Identities = 55/181 (31%), Positives = 82/181 (46%), Gaps = 34/181 (18%) Query 246 TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGY------RGYLDRVEVRDGQRRH---- 295 TG + VGLGPGD MT ++ E+ A D+I Y R + R + H Sbjct 7 TGRLYGVGLGPGDPSLMTVRA-VEVIADADVIAYHSARHGRSIARSIAARHIRPDHVEEA 65 Query 296 -----PSDNTDEP-------------ARARLACSLADQGRAVAVVSSGDPGVFAMATAVL 337 ++ TD P A ARLA L D GR VAV++ GDP + + Sbjct 66 LVYPVTTETTDHPGGYRGAMEDFYTEAAARLAVHL-DAGRTVAVLAEGDPLFYGSYMHMH 124 Query 338 EE-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAA 396 + A+++ V+P +T+ A+R+GAPL V+++ P + + ARL A A Sbjct 125 KRLADRY---ETEVVPGVTSVSGAAARLGAPLVEGDEVLTILPGTLPEEELTARLAATDA 181 Query 397 A 397 A Sbjct 182 A 182 >gi|297155176|gb|ADI04888.1| bifunctional protein S-adenosyl-L-methionine-precorrin-2 methyl transferase\precorrin-3 methylase [Streptomyces bingchenggensis BCW-1] Length=498 Score = 542 bits (1396), Expect = 6e-152, Method: Compositional matrix adjust. Identities = 325/500 (65%), Positives = 374/500 (75%), Gaps = 19/500 (3%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A VI EADVVAYHSA HG SIAR IAE +LRP +EE LV Sbjct 7 GRLYGVGLGPGDPSLMTVRAVEVIAEADVVAYHSARHGRSIARSIAERHLRPDHIEERLV 66 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GA+E+FYADA R+A HLDAGR VA+LAEGDPLFY SYMH+H RL Sbjct 67 YPVTTETTDHPGGYRGAMEEFYADAAARLAAHLDAGRTVAVLAEGDPLFYGSYMHMHKRL 126 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ +VPGVTSVSAA+A + PLV G++VL+VLPGTLP ELT RLA DAA V+KL Sbjct 127 ADRYPTEVVPGVTSVSAAAARIGAPLVEGEEVLTVLPGTLPEEELTARLATTDAAAVMKL 186 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPG------ 238 GR++ VR AL SG L +A YVERA+ +RV P A+VD SVPYFS+A+LP Sbjct 187 GRTFPAVRRALERSGRLAEAQYVERATMGAERVAPLAEVDPESVPYFSVAVLPSRIDAQA 246 Query 239 -GRRRALLTGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPS 297 RR G V VVGLGP W+TP++R ELAAA DL+GY YLDRV R GQRRH S Sbjct 247 PARR-----GEVVVVGLGPAGPLWLTPEARGELAAAEDLVGYTTYLDRVPKRPGQRRHTS 301 Query 298 DNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEAEQWP--GVRVRVIPAMT 355 DN E RA A LA +GR VAVVSSGDPGVFAMATAVLE A + P V VRV+P MT Sbjct 302 DNKVEAERAEFALDLARRGRRVAVVSSGDPGVFAMATAVLEAAAEDPYREVPVRVVPGMT 361 Query 356 AAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQV 415 AA A A+R GAPLGHDYAVISLSDRLKPW+VIA RL AAAAADLVLA+YNP S +R WQV Sbjct 362 AAHAAAARAGAPLGHDYAVISLSDRLKPWEVIAERLRAAAAADLVLALYNPGSRSRIWQV 421 Query 416 GAMRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQT 475 G RELLL HR P PVV+GR+ V GP E +R+VKLADL+PA++DMR +L+VGSSQT Sbjct 422 GKARELLLEHRAPDTPVVLGRD----VGGPEERIRIVKLADLDPAQVDMRTILLVGSSQT 477 Query 476 RWYSV-DSQDRVFTPRRYPE 494 R D + V+TPRRYPE Sbjct 478 RTARRGDGTEIVWTPRRYPE 497 Score = 47.4 bits (111), Expect = 0.005, Method: Compositional matrix adjust. Identities = 57/191 (30%), Positives = 84/191 (44%), Gaps = 33/191 (17%) Query 246 TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLD-RVEVRDGQRRH--------- 295 TG + VGLGPGD MT ++ E+ A D++ Y R R RH Sbjct 6 TGRLYGVGLGPGDPSLMTVRA-VEVIAEADVVAYHSARHGRSIARSIAERHLRPDHIEER 64 Query 296 -----PSDNTDEPARARLACS------------LADQGRAVAVVSSGDPGVFAMATAVLE 338 ++ TD P R A D GR VAV++ GDP + + + Sbjct 65 LVYPVTTETTDHPGGYRGAMEEFYADAAARLAAHLDAGRTVAVLAEGDPLFYGSYMHMHK 124 Query 339 E-AEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVIAARL-TAAAA 396 A+++P V+P +T+ A A+R+GAPL V+++ P + + ARL T AA Sbjct 125 RLADRYP---TEVVPGVTSVSAAAARIGAPLVEGEEVLTVLPGTLPEEELTARLATTDAA 181 Query 397 ADLVLAIYNPA 407 A + L PA Sbjct 182 AVMKLGRTFPA 192 >gi|302523275|ref|ZP_07275617.1| precorrin-3B C17-methyltransferase [Streptomyces sp. SPB78] gi|302432170|gb|EFL03986.1| precorrin-3B C17-methyltransferase [Streptomyces sp. SPB78] Length=496 Score = 542 bits (1396), Expect = 6e-152, Method: Compositional matrix adjust. Identities = 307/497 (62%), Positives = 365/497 (74%), Gaps = 12/497 (2%) Query 5 GTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHGHSIARGIAEPYLRPGQLEEHLV 64 G L+GVGLGPGDP L+TV+A VIGEADV+AYHSA HG SIARGIAE YLR +EE LV Sbjct 3 GKLYGVGLGPGDPSLLTVRAVEVIGEADVIAYHSARHGRSIARGIAERYLREDHVEELLV 62 Query 65 YPVTTEATNHPGGYAGALEDFYADATERIATHLDAGRNVALLAEGDPLFYSSYMHLHTRL 124 YPVTTE T+HPGGY GALE+FY +A R+A HLDAGR VA+LAEGDP FY SY H+H RL Sbjct 63 YPVTTETTDHPGGYRGALEEFYEEAAARLAAHLDAGRTVAVLAEGDPFFYGSYQHMHKRL 122 Query 125 TRRFNAVIVPGVTSVSAASAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKL 184 R+ +VPGVTS +AASA + PLV G++VL+VLPGTLP EL RLA D+AVV+KL Sbjct 123 AHRYETEVVPGVTSFAAASARLGRPLVEGEEVLTVLPGTLPEEELAARLAATDSAVVMKL 182 Query 185 GRSYHNVREALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLP----GGR 240 GR++ VR AL +SG L +A YVERA+ G+R ADVD VPYFS+A+LP GR Sbjct 183 GRTFPKVRRALESSGRLDEARYVERATMDGERTAALADVDAAGVPYFSVAVLPSRVAAGR 242 Query 241 RRALL-TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVEVRDGQRRHPSDN 299 + V VVG GP W+TP+SR LAAA DL+GY Y+ RV R GQ RH SDN Sbjct 243 PEPVAGRAEVVVVGTGPAGPLWLTPESRGALAAADDLVGYATYIGRVPERPGQSRHASDN 302 Query 300 TDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVLEEA--EQWPGVRVRVIPAMTAA 357 E RA A LA +GR VAVVS GDPGVFAMATAVLE A +++ V VRV+P +TAA Sbjct 303 RVESERAEFALQLAARGRRVAVVSGGDPGVFAMATAVLEVASRKEYTDVPVRVLPGVTAA 362 Query 358 QAVASRVGAPLGHDYAVISLSDRLKPWDVIAARLTAAAAADLVLAIYNPASVTRTWQVGA 417 A A+R GAPLGHDYAV SLSDRLKPW+V+A RL AAA ADLVLA+YNP S +RTWQVGA Sbjct 363 NAAAARAGAPLGHDYAVFSLSDRLKPWEVVARRLRAAAGADLVLALYNPGSGSRTWQVGA 422 Query 418 MRELLLAHRDPGIPVVIGRNVSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRW 477 R++LL HR PG PVV+ R+ V G E VR+V+LADL+PAE+DMR +L+VGSS+TR Sbjct 423 ARDVLLEHRAPGTPVVVARD----VGGAGERVRIVRLADLDPAEVDMRTILLVGSSRTRV 478 Query 478 YSV-DSQDRVFTPRRYP 493 D ++ V+TPRRYP Sbjct 479 VRRGDGEEIVWTPRRYP 495 Lambda K H 0.318 0.133 0.391 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1101757964944 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40