BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2071c Length=251 Score E Sequences producing significant alignments: (Bits) Value gi|15609208|ref|NP_216587.1| precorrin-4 C11-methyltransferase C... 494 5e-138 gi|254364884|ref|ZP_04980930.1| precorrin-4 c11-methyltransferas... 494 5e-138 gi|15841560|ref|NP_336597.1| precorrin-4 C11-methyltransferase [... 494 5e-138 gi|289745345|ref|ZP_06504723.1| precorrin-4 C11-methyltransferas... 493 9e-138 gi|31793254|ref|NP_855747.1| precorrin-4 C11-methyltransferase C... 493 9e-138 gi|289447691|ref|ZP_06437435.1| precorrin-6x reductase cobK [Myc... 490 7e-137 gi|240172460|ref|ZP_04751119.1| precorrin-4 C11-methyltransferas... 409 2e-112 gi|183983054|ref|YP_001851345.1| precorrin-4 C11-methyltransfera... 409 2e-112 gi|118617813|ref|YP_906145.1| precorrin-4 C11-methyltransferase,... 405 3e-111 gi|296165164|ref|ZP_06847712.1| precorrin-4 C(11)-methyltransfer... 399 2e-109 gi|254819628|ref|ZP_05224629.1| precorrin-4 C11-methyltransferas... 396 1e-108 gi|342859786|ref|ZP_08716439.1| precorrin-4 C11-methyltransferas... 383 1e-104 gi|41407914|ref|NP_960750.1| hypothetical protein MAP1816c [Myco... 383 1e-104 gi|254775089|ref|ZP_05216605.1| precorrin-4 C11-methyltransferas... 380 1e-103 gi|118464616|ref|YP_881621.1| precorrin-4 C11-methyltransferase ... 379 3e-103 gi|118467827|ref|YP_888168.1| precorrin-4 C11-methyltransferase ... 374 1e-101 gi|126435105|ref|YP_001070796.1| precorrin-4 C11-methyltransfera... 373 1e-101 gi|108799451|ref|YP_639648.1| precorrin-4 C11-methyltransferase ... 368 4e-100 gi|169629282|ref|YP_001702931.1| precorrin-4 C11-methyltransfera... 329 2e-88 gi|296270465|ref|YP_003653097.1| precorrin-4 C11-methyltransfera... 307 9e-82 gi|111017846|ref|YP_700818.1| precorrin-4 C(11)-methyltransferas... 304 7e-81 gi|18202560|sp|Q53138.1|COBM_RHOER RecName: Full=Precorrin-4 C(1... 301 4e-80 gi|226359979|ref|YP_002777757.1| precorrin-4 C11-methyltransfera... 301 7e-80 gi|86740228|ref|YP_480628.1| precorrin-4 C11-methyltransferase [... 297 1e-78 gi|229493630|ref|ZP_04387415.1| precorrin-4 C11-methyltransferas... 292 4e-77 gi|226306646|ref|YP_002766606.1| precorrin-4 C11-methyltransfera... 291 9e-77 gi|111221766|ref|YP_712560.1| precorrin-4 C11-methyltransferase ... 290 1e-76 gi|325676810|ref|ZP_08156483.1| precorrin-4 C(11)-methyltransfer... 286 2e-75 gi|333919695|ref|YP_004493276.1| Precorrin-4 C(11)-methyltransfe... 285 5e-75 gi|295835352|ref|ZP_06822285.1| precorrin-4 C(11)-methyltransfer... 283 1e-74 gi|312139739|ref|YP_004007075.1| precorrin-4 c11-methyltransfera... 283 1e-74 gi|337290707|ref|YP_004629728.1| precorrin-4 C11-methyltransfera... 283 2e-74 gi|311899846|dbj|BAJ32254.1| putative precorrin-4 C11-methyltran... 282 4e-74 gi|300858445|ref|YP_003783428.1| precorrin-4 C11-methyltransfera... 281 6e-74 gi|302537652|ref|ZP_07289994.1| precorrin-4 C11-methyltransferas... 281 7e-74 gi|318059049|ref|ZP_07977772.1| precorrin-4 C11-methyltransferas... 280 1e-73 gi|297194619|ref|ZP_06912017.1| precorrin-4 C11-methyltransferas... 280 1e-73 gi|328883574|emb|CCA56813.1| Cobalt-precorrin-4 C11-methyltransf... 279 3e-73 gi|297155179|gb|ADI04891.1| precorrin-4 C11-methyltransferase [S... 278 4e-73 gi|333022913|ref|ZP_08450977.1| putative precorrin-4 C(11)-methy... 278 7e-73 gi|271966897|ref|YP_003341093.1| precorrin-4 C(11)-methyltransfe... 278 7e-73 gi|213965555|ref|ZP_03393749.1| precorrin-4 C11-methyltransferas... 276 2e-72 gi|256375913|ref|YP_003099573.1| precorrin-4 C11-methyltransfera... 276 2e-72 gi|290955554|ref|YP_003486736.1| precorrin-4 C11-methyltransfera... 274 8e-72 gi|305680827|ref|ZP_07403634.1| precorrin-4 C(11)-methyltransfer... 273 1e-71 gi|345011364|ref|YP_004813718.1| precorrin-4 C11-methyltransfera... 273 2e-71 gi|225021469|ref|ZP_03710661.1| hypothetical protein CORMATOL_01... 273 2e-71 gi|300788885|ref|YP_003769176.1| precorrin-4 C11-methyltransfera... 272 4e-71 gi|337763716|emb|CCB72426.1| Precorrin-4 C(11)-methyltransferase... 271 5e-71 gi|302554737|ref|ZP_07307079.1| precorrin-4 C11-methyltransferas... 270 1e-70 >gi|15609208|ref|NP_216587.1| precorrin-4 C11-methyltransferase CobM [Mycobacterium tuberculosis H37Rv] gi|148661885|ref|YP_001283408.1| precorrin-4 c11-methyltransferase [Mycobacterium tuberculosis H37Ra] gi|148823286|ref|YP_001288040.1| precorrin-4 C11-methyltransferase cobM [Mycobacterium tuberculosis F11] 17 more sequence titles Length=251 Score = 494 bits (1272), Expect = 5e-138, Method: Compositional matrix adjust. Identities = 251/251 (100%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG Sbjct 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL Sbjct 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Query 241 YSVARHGRYAQ 251 YSVARHGRYAQ Sbjct 241 YSVARHGRYAQ 251 >gi|254364884|ref|ZP_04980930.1| precorrin-4 c11-methyltransferase cobM [Mycobacterium tuberculosis str. Haarlem] gi|289554145|ref|ZP_06443355.1| precorrin-4 c11-methyltransferase cobM [Mycobacterium tuberculosis KZN 605] gi|308232021|ref|ZP_07414646.2| precorrin-4 c11-methyltransferase cobM [Mycobacterium tuberculosis SUMu001] 24 more sequence titles Length=257 Score = 494 bits (1272), Expect = 5e-138, Method: Compositional matrix adjust. Identities = 251/251 (100%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE Sbjct 7 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 66 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL Sbjct 67 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 126 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG Sbjct 127 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 186 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL Sbjct 187 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 246 Query 241 YSVARHGRYAQ 251 YSVARHGRYAQ Sbjct 247 YSVARHGRYAQ 257 >gi|15841560|ref|NP_336597.1| precorrin-4 C11-methyltransferase [Mycobacterium tuberculosis CDC1551] gi|13881807|gb|AAK46411.1| precorrin-4 C11-methyltransferase [Mycobacterium tuberculosis CDC1551] Length=266 Score = 494 bits (1271), Expect = 5e-138, Method: Compositional matrix adjust. Identities = 251/251 (100%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE Sbjct 16 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 75 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL Sbjct 76 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 135 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG Sbjct 136 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 195 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL Sbjct 196 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 255 Query 241 YSVARHGRYAQ 251 YSVARHGRYAQ Sbjct 256 YSVARHGRYAQ 266 >gi|289745345|ref|ZP_06504723.1| precorrin-4 C11-methyltransferase [Mycobacterium tuberculosis 02_1987] gi|289685873|gb|EFD53361.1| precorrin-4 C11-methyltransferase [Mycobacterium tuberculosis 02_1987] Length=257 Score = 493 bits (1269), Expect = 9e-138, Method: Compositional matrix adjust. Identities = 250/251 (99%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE Sbjct 7 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 66 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL Sbjct 67 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 126 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLSTP+PPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG Sbjct 127 KRELTVPGVAQTVTLTRVATLSTPMPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 186 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL Sbjct 187 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 246 Query 241 YSVARHGRYAQ 251 YSVARHGRYAQ Sbjct 247 YSVARHGRYAQ 257 >gi|31793254|ref|NP_855747.1| precorrin-4 C11-methyltransferase CobM [Mycobacterium bovis AF2122/97] gi|121637956|ref|YP_978180.1| putative precorrin-4 C11-methyltransferase CobM [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990450|ref|YP_002645137.1| putative precorrin-4 C11-methyltransferase [Mycobacterium bovis BCG str. Tokyo 172] 26 more sequence titles Length=251 Score = 493 bits (1269), Expect = 9e-138, Method: Compositional matrix adjust. Identities = 250/251 (99%), Positives = 251/251 (100%), Gaps = 0/251 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLSTP+PPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG Sbjct 121 KRELTVPGVAQTVTLTRVATLSTPMPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL Sbjct 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Query 241 YSVARHGRYAQ 251 YSVARHGRYAQ Sbjct 241 YSVARHGRYAQ 251 >gi|289447691|ref|ZP_06437435.1| precorrin-6x reductase cobK [Mycobacterium tuberculosis CPHL_A] gi|289420649|gb|EFD17850.1| precorrin-6x reductase cobK [Mycobacterium tuberculosis CPHL_A] Length=251 Score = 490 bits (1262), Expect = 7e-137, Method: Compositional matrix adjust. Identities = 249/251 (99%), Positives = 250/251 (99%), Gaps = 0/251 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIV TGPLTLE Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVGTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLSTP+PPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG Sbjct 121 KRELTVPGVAQTVTLTRVATLSTPMPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL Sbjct 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Query 241 YSVARHGRYAQ 251 YSVARHGRYAQ Sbjct 241 YSVARHGRYAQ 251 >gi|240172460|ref|ZP_04751119.1| precorrin-4 C11-methyltransferase, CobM [Mycobacterium kansasii ATCC 12478] Length=249 Score = 409 bits (1052), Expect = 2e-112, Method: Compositional matrix adjust. Identities = 215/245 (88%), Positives = 225/245 (92%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLL+RCPVCLYAGSIMP DLLA CPP A IVDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLERCPVCLYAGSIMPKDLLAHCPPDAKIVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIV +LA ADA G DVARLHSGDPSLYSALAEQCR LDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QIVTELATADAAGHDVARLHSGDPSLYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTL+R+ATLSTP+PPGEDLA LA+S ATLVLHLAAAQIDAIVP+LL G Sbjct 121 KRELTVPGVAQTVTLSRIATLSTPMPPGEDLATLAKSGATLVLHLAAAQIDAIVPQLLSG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWPQQ LRGTLA IAA+MHDA IT+TAVI+VGDVL A GFTDSYL Sbjct 181 GYRPETPTAVVAFASWPQQCVLRGTLAGIAAQMHDAGITKTAVIIVGDVLAAAGFTDSYL 240 Query 241 YSVAR 245 YS AR Sbjct 241 YSTAR 245 >gi|183983054|ref|YP_001851345.1| precorrin-4 C11-methyltransferase, CobM [Mycobacterium marinum M] gi|183176380|gb|ACC41490.1| precorrin-4 C11-methyltransferase, CobM [Mycobacterium marinum M] Length=249 Score = 409 bits (1051), Expect = 2e-112, Method: Compositional matrix adjust. Identities = 212/249 (86%), Positives = 228/249 (92%), Gaps = 0/249 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLIT+RGQRLLQ CPVCLYAGSIMPDDLLA CPP A +VDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGSIMPDDLLAYCPPEAKVVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +LA A A G DVARLHSGDPSLYSALAEQCR LDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QIITELAAAHAAGHDVARLHSGDPSLYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRE TVPGV+QTVTLTR++TLSTP+PPGEDLAALA+ ATLVLHLAAAQIDAIVP+LL G Sbjct 121 KREFTVPGVSQTVTLTRISTLSTPMPPGEDLAALAKPGATLVLHLAAAQIDAIVPQLLAG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWPQQ LRGTL+DIAA+MH+A IT+TAVIVVGDVL A+GFTDSYL Sbjct 181 GYRPETPAAVVAFASWPQQAVLRGTLSDIAAQMHNANITKTAVIVVGDVLAADGFTDSYL 240 Query 241 YSVARHGRY 249 YSVAR G + Sbjct 241 YSVARRGAH 249 >gi|118617813|ref|YP_906145.1| precorrin-4 C11-methyltransferase, CobM [Mycobacterium ulcerans Agy99] gi|118569923|gb|ABL04674.1| precorrin-4 C11-methyltransferase, CobM [Mycobacterium ulcerans Agy99] Length=249 Score = 405 bits (1041), Expect = 3e-111, Method: Compositional matrix adjust. Identities = 210/249 (85%), Positives = 227/249 (92%), Gaps = 0/249 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLIT+RGQRLLQ CPVCLYAGSIMPDDLLA CP A +VDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITLRGQRLLQSCPVCLYAGSIMPDDLLAYCPVEAKVVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +LA A A G DVARLHSGDPSLYSALAEQCR LDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QIITELAAAHAAGHDVARLHSGDPSLYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRE TVPGV+QTVTLTR++TLSTP+PPGEDLAALA+ ATLVLHLAAAQIDAI+P+LL G Sbjct 121 KREFTVPGVSQTVTLTRISTLSTPMPPGEDLAALAKPGATLVLHLAAAQIDAIIPQLLAG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWPQQ LRGTL+DIAA+MH+A IT+TAVIVVGDVL A+GFTDSYL Sbjct 181 GYRPETPAAVVAFASWPQQAVLRGTLSDIAAQMHNANITKTAVIVVGDVLAADGFTDSYL 240 Query 241 YSVARHGRY 249 YSVAR G + Sbjct 241 YSVARRGAH 249 >gi|296165164|ref|ZP_06847712.1| precorrin-4 C(11)-methyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295899472|gb|EFG78930.1| precorrin-4 C(11)-methyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=251 Score = 399 bits (1024), Expect = 2e-109, Method: Compositional matrix adjust. Identities = 212/245 (87%), Positives = 224/245 (92%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLL+ CPVCLYAGSIMPDDLLA CPPGA +VDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLESCPVCLYAGSIMPDDLLALCPPGAKVVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +LADA A G DVARLHSGDPSLYSALAEQCR LDALGI YEIVPGVP+FAAAAAAL Sbjct 61 QIIAELADAAAAGHDVARLHSGDPSLYSALAEQCRRLDALGIDYEIVPGVPSFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLST +PPGEDLA LARS ATLVLHLAAAQ+DAIVP+LL+G Sbjct 121 KRELTVPGVAQTVTLTRVATLSTAMPPGEDLATLARSGATLVLHLAAAQVDAIVPQLLEG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWPQQ LRGTLADIAA+MH A + +TAVIVVGDVL AEGFTDSYL Sbjct 181 GYRPETPAAVVAFASWPQQVVLRGTLADIAAQMHRAGVNKTAVIVVGDVLAAEGFTDSYL 240 Query 241 YSVAR 245 YS R Sbjct 241 YSTGR 245 >gi|254819628|ref|ZP_05224629.1| precorrin-4 C11-methyltransferase [Mycobacterium intracellulare ATCC 13950] Length=251 Score = 396 bits (1018), Expect = 1e-108, Method: Compositional matrix adjust. Identities = 211/245 (87%), Positives = 221/245 (91%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQ CPVCLYAGSIMPDDLLA CP A IVDTGPLTLE Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQTCPVCLYAGSIMPDDLLALCPQDAKIVDTGPLTLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +L +A A G DVARLHSGDPSLYSALAEQCR LDALGI YEIVPGVPAFAAAAAAL Sbjct 61 QIIAELREAHAAGHDVARLHSGDPSLYSALAEQCRRLDALGIDYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTLTRVATLST +PPGEDLA LARS ATLVLHLAAAQIDAIVP+LLDG Sbjct 121 KRELTVPGVAQTVTLTRVATLSTAMPPGEDLATLARSGATLVLHLAAAQIDAIVPQLLDG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYR ETPVAVVAFASWPQ+ LRGTLADIAA+MH+A IT+TAVI+VGD LTA FTDSYL Sbjct 181 GYRSETPVAVVAFASWPQETVLRGTLADIAAQMHEANITKTAVILVGDALTAGEFTDSYL 240 Query 241 YSVAR 245 YS R Sbjct 241 YSTGR 245 >gi|342859786|ref|ZP_08716439.1| precorrin-4 C11-methyltransferase [Mycobacterium colombiense CECT 3035] gi|342132918|gb|EGT86138.1| precorrin-4 C11-methyltransferase [Mycobacterium colombiense CECT 3035] Length=499 Score = 383 bits (984), Expect = 1e-104, Method: Compositional matrix adjust. Identities = 201/245 (83%), Positives = 215/245 (88%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 +TVYFIGAGPGAADLITVRGQRLLQ C VCLYAGSIMPDDLLA CPP A +VDTGPLTL+ Sbjct 6 VTVYFIGAGPGAADLITVRGQRLLQTCRVCLYAGSIMPDDLLALCPPDAKVVDTGPLTLD 65 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIV +L++A A G DVARLHSGDPSLYSALAEQCR LD+LGI YEIVPGVPAF AAAAAL Sbjct 66 QIVAELSEAHAAGLDVARLHSGDPSLYSALAEQCRRLDSLGIAYEIVPGVPAFTAAAAAL 125 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTL+RVATLST +PPGEDL LA TLVLHLAAAQIDAIVP+LL+ Sbjct 126 KRELTVPGVAQTVTLSRVATLSTAMPPGEDLKTLAHCGGTLVLHLAAAQIDAIVPQLLEA 185 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWPQ+ LRGTLADIA +MH A IT+TAVIVVGD LTA GFTDSYL Sbjct 186 GYRPETPAAVVAFASWPQETVLRGTLADIAGQMHRAGITKTAVIVVGDALTAGGFTDSYL 245 Query 241 YSVAR 245 YS R Sbjct 246 YSAGR 250 >gi|41407914|ref|NP_960750.1| hypothetical protein MAP1816c [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396268|gb|AAS04133.1| CobM [Mycobacterium avium subsp. paratuberculosis K-10] gi|336462053|gb|EGO40899.1| precorrin-4 C11-methyltransferase [Mycobacterium avium subsp. paratuberculosis S397] Length=251 Score = 383 bits (983), Expect = 1e-104, Method: Compositional matrix adjust. Identities = 204/245 (84%), Positives = 217/245 (89%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQ CPVCLYAGSIMPDDLLA CPP A IVDTGPLTL+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQSCPVCLYAGSIMPDDLLALCPPDARIVDTGPLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI +L A A G DVARLHSGDPSLYSALAEQCR LDALGIGYEIVPGVPAFAAAAAAL Sbjct 61 QITTELRRAHAAGHDVARLHSGDPSLYSALAEQCRRLDALGIGYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTL+RVATLST +PPGEDLA LAR+ TLVLHLAAAQID+IV +LLD Sbjct 121 KRELTVPGVAQTVTLSRVATLSTAMPPGEDLATLARTGGTLVLHLAAAQIDSIVGQLLDN 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 G + +TP AVVAFASWPQQ LRGTL DIAA+MHDA+IT+TAVI+VGD LTA GFTDSYL Sbjct 181 GRQSQTPCAVVAFASWPQQTVLRGTLDDIAAQMHDARITKTAVIIVGDALTAGGFTDSYL 240 Query 241 YSVAR 245 YS R Sbjct 241 YSTGR 245 >gi|254775089|ref|ZP_05216605.1| precorrin-4 C11-methyltransferase [Mycobacterium avium subsp. avium ATCC 25291] Length=251 Score = 380 bits (976), Expect = 1e-103, Method: Compositional matrix adjust. Identities = 202/245 (83%), Positives = 217/245 (89%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQ CPVCLYAGSIM DDLLA CPP A IVDTGPLTL+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQSCPVCLYAGSIMRDDLLALCPPDARIVDTGPLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +L+ A A G DVARLHSGDPSLYSALAEQCR LDALGI YEIVPGVPAFAAAAAAL Sbjct 61 QIITELSQAHAAGHDVARLHSGDPSLYSALAEQCRRLDALGIDYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTL+RVATLST +PPGEDLA LAR+ TLVLHLAAAQID+IV +LLD Sbjct 121 KRELTVPGVAQTVTLSRVATLSTAMPPGEDLATLARTGGTLVLHLAAAQIDSIVGQLLDN 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 G +P+TP AVVAFASWPQ+ LRGTL DIAA+MHDA IT+TAVI+VGD LTA GFTDSYL Sbjct 181 GRQPQTPCAVVAFASWPQETVLRGTLDDIAAQMHDAHITKTAVIIVGDALTAGGFTDSYL 240 Query 241 YSVAR 245 YS R Sbjct 241 YSTGR 245 >gi|118464616|ref|YP_881621.1| precorrin-4 C11-methyltransferase [Mycobacterium avium 104] gi|118165903|gb|ABK66800.1| precorrin-4 C11-methyltransferase [Mycobacterium avium 104] Length=251 Score = 379 bits (972), Expect = 3e-103, Method: Compositional matrix adjust. Identities = 201/245 (83%), Positives = 216/245 (89%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLLQ CPVCLYAGSIMPDDLLA CPP A IVDTGPLTL+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLQSCPVCLYAGSIMPDDLLALCPPDARIVDTGPLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +L+ A A G DVARLHSGDPSLYSALAEQCR LDALGI YEIVPGVPAFAAAAAAL Sbjct 61 QIITELSQAHAAGHDVARLHSGDPSLYSALAEQCRRLDALGIDYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGVAQTVTL+RVATLST +PPGEDLA LAR+ TLVL LAAAQID+IV +LLD Sbjct 121 KRELTVPGVAQTVTLSRVATLSTAMPPGEDLATLARTGGTLVLQLAAAQIDSIVGQLLDN 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 G + +TP AVVAFASWPQ+ LRGTL DIAA+MHDA IT+TAVI+VGD LTA GFTDSYL Sbjct 181 GRQSQTPCAVVAFASWPQETVLRGTLDDIAAQMHDAHITKTAVIIVGDALTAGGFTDSYL 240 Query 241 YSVAR 245 YS R Sbjct 241 YSTGR 245 >gi|118467827|ref|YP_888168.1| precorrin-4 C11-methyltransferase [Mycobacterium smegmatis str. MC2 155] gi|118169114|gb|ABK70010.1| precorrin-4 C11-methyltransferase [Mycobacterium smegmatis str. MC2 155] Length=251 Score = 374 bits (959), Expect = 1e-101, Method: Compositional matrix adjust. Identities = 197/245 (81%), Positives = 212/245 (87%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLL C VCLYAGSIMPDDLLA CPP A ++DTGPL L+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLGTCKVCLYAGSIMPDDLLALCPPDAKVIDTGPLNLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ +L AD G DVARLHSGDPS+YSALAEQCR LDALGIGYEIVPGVPAFAA AAAL Sbjct 61 QIIDELVAADEAGLDVARLHSGDPSIYSALAEQCRRLDALGIGYEIVPGVPAFAAVAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGVAQTVTL+RVATLST +P GEDL L+ ATLVLHLAAAQID IVP+L++G Sbjct 121 GRELTVPGVAQTVTLSRVATLSTAMPEGEDLRTLSAPGATLVLHLAAAQIDNIVPQLIEG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWPQ+ LRGTLADIA +MH A +TRTAVIVVGDVL AEGFTDSYL Sbjct 181 GYRPETPCAVVAFASWPQEVVLRGTLADIAEQMHAADVTRTAVIVVGDVLAAEGFTDSYL 240 Query 241 YSVAR 245 YS R Sbjct 241 YSATR 245 >gi|126435105|ref|YP_001070796.1| precorrin-4 C11-methyltransferase [Mycobacterium sp. JLS] gi|126234905|gb|ABN98305.1| precorrin-4 C11-methyltransferase [Mycobacterium sp. JLS] Length=250 Score = 373 bits (957), Expect = 1e-101, Method: Compositional matrix adjust. Identities = 202/251 (81%), Positives = 219/251 (88%), Gaps = 3/251 (1%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLL RCPVCLYAGSIMP+DLLA CPP A IVDTGPLTL+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLGRCPVCLYAGSIMPEDLLALCPPDARIVDTGPLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIV +LA A ADG+DVARLHSGDPS+YSALAEQCR LDALG+ YEIVPGVPAFAAAAAAL Sbjct 61 QIVDELAQAHADGKDVARLHSGDPSIYSALAEQCRRLDALGVDYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVPGV+QTVTL+RVATLST +PPGEDL L+ S TLVLHLAAAQID IVP LL G Sbjct 121 GHELTVPGVSQTVTLSRVATLSTAMPPGEDLRTLSASGGTLVLHLAAAQIDNIVPELLAG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GYRPETP AVVAFASWP++ LRGTLADIAA+MHDA +TRTAVIV+GDVL A G T+SYL Sbjct 181 GYRPETPCAVVAFASWPEEIVLRGTLADIAAQMHDAAVTRTAVIVIGDVLAAGG-TESYL 239 Query 241 YSVA--RHGRY 249 YS R GR+ Sbjct 240 YSSGRVRRGRH 250 >gi|108799451|ref|YP_639648.1| precorrin-4 C11-methyltransferase [Mycobacterium sp. MCS] gi|119868564|ref|YP_938516.1| precorrin-4 C11-methyltransferase [Mycobacterium sp. KMS] gi|108769870|gb|ABG08592.1| precorrin-4 C11-methyltransferase [Mycobacterium sp. MCS] gi|119694653|gb|ABL91726.1| precorrin-4 C11-methyltransferase [Mycobacterium sp. KMS] Length=250 Score = 368 bits (945), Expect = 4e-100, Method: Compositional matrix adjust. Identities = 200/251 (80%), Positives = 217/251 (87%), Gaps = 3/251 (1%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQRLL RCPVCLYAGSIMP+DLLA CPP A IVDTGPLTL+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRLLGRCPVCLYAGSIMPEDLLALCPPDARIVDTGPLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIV +LA A ADG+DVARLHSGDPS+YSALAEQCR LDALG+ YEIVPGVPAFAAAAAAL Sbjct 61 QIVDELAQAHADGKDVARLHSGDPSIYSALAEQCRRLDALGVDYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVPGV+QTVTL+RVATLST +PPGEDL L+ S TLVLHLAAA ID IVP LL G Sbjct 121 GHELTVPGVSQTVTLSRVATLSTAMPPGEDLRTLSASGGTLVLHLAAAHIDNIVPELLAG 180 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GY PETP AVVAFASWP++ LRGTLADIAA+MHDA +TRTAVIV+GDVL A G T+SYL Sbjct 181 GYGPETPCAVVAFASWPEEIVLRGTLADIAAQMHDAAVTRTAVIVIGDVLAAGG-TESYL 239 Query 241 YSVA--RHGRY 249 YS R GR+ Sbjct 240 YSSGRVRRGRH 250 >gi|169629282|ref|YP_001702931.1| precorrin-4 C11-methyltransferase CobM [Mycobacterium abscessus ATCC 19977] gi|169241249|emb|CAM62277.1| Probable precorrin-4 C11-methyltransferase CobM [Mycobacterium abscessus] Length=266 Score = 329 bits (843), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 182/245 (75%), Positives = 208/245 (85%), Gaps = 0/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQR+L++C VCLYAGSIMPDDLLA+CPPGA +VDTGPLTL+ Sbjct 16 MTVYFIGAGPGAADLITVRGQRILRQCSVCLYAGSIMPDDLLAECPPGARVVDTGPLTLD 75 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 I+ +++ ADA+G DVARLHSGDPSLYSA+AEQCR LD LGI +EIVPGVPAFAAAAAAL Sbjct 76 AIIEEISAADAEGLDVARLHSGDPSLYSAVAEQCRRLDVLGIDHEIVPGVPAFAAAAAAL 135 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVPGVAQTVT+TRV+TLST +P GEDL LA ATL LHLAAAQID + L+ G Sbjct 136 GTELTVPGVAQTVTITRVSTLSTAMPEGEDLRTLAAPGATLALHLAAAQIDTVAADLVAG 195 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 GY +TPVAVVA+ASWP + LRGTLADIA ++ +A +T+TAVI VG VL AEGFTDSYL Sbjct 196 GYPSDTPVAVVAYASWPSETILRGTLADIAGQLKEAAVTKTAVIFVGKVLAAEGFTDSYL 255 Query 241 YSVAR 245 YS R Sbjct 256 YSSGR 260 >gi|296270465|ref|YP_003653097.1| precorrin-4 C11-methyltransferase [Thermobispora bispora DSM 43833] gi|296093252|gb|ADG89204.1| precorrin-4 C11-methyltransferase [Thermobispora bispora DSM 43833] Length=251 Score = 307 bits (787), Expect = 9e-82, Method: Compositional matrix adjust. Identities = 170/246 (70%), Positives = 201/246 (82%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG RLL+ PVCLYAGS++P +LLA+CPP A +VDT LTL+ Sbjct 1 MTVYFIGAGPGAADLITVRGLRLLRSAPVCLYAGSLVPRELLAECPPDARLVDTANLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ ++A A A G+DVARLHSGDPS++SA+AEQ R LDALG+ YEIVPGVPAFAAAAAAL Sbjct 61 QIIDEIAAAHARGQDVARLHSGDPSIFSAVAEQMRRLDALGVPYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 +RELTVPGVAQTV LTR A +TP+PPGEDLA L SR+T+VLHLA +IDA+V LL Sbjct 121 RRELTVPGVAQTVILTRTAARATPMPPGEDLATLGASRSTIVLHLAVQRIDAVVAELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y P+ PVAVVA+AS +R LRGTLADIAA++ +A + RTAVI+VG LTA F DS+L Sbjct 180 NYGPDCPVAVVAYASRDDERILRGTLADIAAKVREAGVRRTAVIIVGRALTAAEFPDSHL 239 Query 241 YSVARH 246 YS AR Sbjct 240 YSPARE 245 >gi|111017846|ref|YP_700818.1| precorrin-4 C(11)-methyltransferase [Rhodococcus jostii RHA1] gi|110817376|gb|ABG92660.1| precorrin-4 C(11)-methyltransferase [Rhodococcus jostii RHA1] Length=249 Score = 304 bits (779), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 155/246 (64%), Positives = 193/246 (79%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADL+TVR QR++ PVCLYAGS++P +LLA+CP GA ++DT L+L+ Sbjct 1 MTVYFIGAGPGAADLVTVRAQRIIAASPVCLYAGSLVPQELLAECPEGARVIDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +IV L +ADA G+DVARLHSGDPS++SA+AEQ R L+A GI Y +VPGVPAF AAAA+L Sbjct 61 EIVALLIEADAAGQDVARLHSGDPSIFSAVAEQVRRLEAAGIAYTVVPGVPAFTAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV+Q++ LTRV+TLST +P GEDL +L RS AT+V+HL A +ID IV L + Sbjct 121 GRELTVPGVSQSIVLTRVSTLSTAMPEGEDLRSLGRSGATMVVHLGAHRIDQIVEELTE- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVAFAS P + LRGTLA IA ++ A +T+TAV++VG VL AEGF DSYL Sbjct 180 NYGRDCPAAVVAFASRPDEIVLRGTLATIADQVKAAGVTKTAVVIVGKVLAAEGFPDSYL 239 Query 241 YSVARH 246 YS R Sbjct 240 YSATRE 245 >gi|18202560|sp|Q53138.1|COBM_RHOER RecName: Full=Precorrin-4 C(11)-methyltransferase; AltName: Full=Precorrin-3 methylase gi|347172|gb|AAC37130.1| S-adenosylmethionine-dependent methylase [Rhodococcus erythropolis] Length=249 Score = 301 bits (772), Expect = 4e-80, Method: Compositional matrix adjust. Identities = 153/246 (63%), Positives = 194/246 (79%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVR QR++ PVCLYAGS++P +LLA+CP GA ++DT L+L+ Sbjct 1 MTVYFIGAGPGAADLITVRAQRIIAASPVCLYAGSLVPQELLAECPEGARVIDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +IV L +ADA G+DVARLHSGDPS++SA+AEQ R L++ G+ Y++VPGVPAF AAAA+L Sbjct 61 EIVALLIEADAAGQDVARLHSGDPSIFSAVAEQVRRLESAGVAYQVVPGVPAFTAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV+Q++ LTRV+TLST +P GEDL +L RS AT+V+HL A +ID I L++ Sbjct 121 GRELTVPGVSQSIVLTRVSTLSTAMPEGEDLRSLGRSGATMVVHLGAHRIDQIAEELIE- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVAFAS P + LRGTLA IA ++ A +T+TAV++VG VL AEGF DSYL Sbjct 180 DYGRDCPAAVVAFASRPDEIVLRGTLATIADQVKAAGVTKTAVVIVGRVLAAEGFPDSYL 239 Query 241 YSVARH 246 YS R Sbjct 240 YSATRE 245 >gi|226359979|ref|YP_002777757.1| precorrin-4 C11-methyltransferase [Rhodococcus opacus B4] gi|226238464|dbj|BAH48812.1| precorrin-4 C11-methyltransferase [Rhodococcus opacus B4] Length=249 Score = 301 bits (770), Expect = 7e-80, Method: Compositional matrix adjust. Identities = 152/246 (62%), Positives = 193/246 (79%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVR QR++ PVCLYAGS++P +LLA+CP GA ++DT L+L+ Sbjct 1 MTVYFIGAGPGAADLITVRAQRIIATSPVCLYAGSLVPQELLAECPEGARVIDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +IV L +ADA G+DVARLHSGDPS++SA+AEQ R L++ G+ + +VPGVPAF AAAA+L Sbjct 61 EIVALLIEADAAGQDVARLHSGDPSIFSAVAEQVRRLESAGVAHTVVPGVPAFTAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV+Q++ LTRV+TLST +P GEDL +L RS AT+V+HL A +ID I L++ Sbjct 121 GRELTVPGVSQSIVLTRVSTLSTAMPEGEDLRSLGRSGATMVVHLGAHRIDQIAEELIE- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVAFAS P + LRGTLA IA ++ A +T+TAV++VG VL AEGF DSYL Sbjct 180 NYGRDCPAAVVAFASRPDEIVLRGTLATIADQVKAAGVTKTAVVIVGKVLAAEGFPDSYL 239 Query 241 YSVARH 246 YS R Sbjct 240 YSATRE 245 >gi|86740228|ref|YP_480628.1| precorrin-4 C11-methyltransferase [Frankia sp. CcI3] gi|86567090|gb|ABD10899.1| precorrin-4 C11-methyltransferase [Frankia sp. CcI3] Length=280 Score = 297 bits (760), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 165/247 (67%), Positives = 192/247 (78%), Gaps = 1/247 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADLITVRG+ L+ CPVCLYAGS++P +LLA CPPGA +VDT + L+ Sbjct 1 MTVHFIGAGPGAADLITVRGRNLIASCPVCLYAGSLVPVELLAHCPPGARLVDTARMPLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 IV +L ADA G DVARLHSGDPSLYSA+AEQ R LDA GI Y++ PGVPAFAAAAA+L Sbjct 61 DIVAELVAADAAGHDVARLHSGDPSLYSAVAEQMRRLDAAGIAYDVTPGVPAFAAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 +RELTVPGVAQ+V LTR A LS+P+PPGEDLA L RS ATLVLHLA +I+ +V L+ Sbjct 121 RRELTVPGVAQSVVLTRTAVLSSPMPPGEDLATLGRSGATLVLHLAVHRIETLVAELVP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA+AS + LRGTLADIA R A +TRTAVI+VG L AEGF DSYL Sbjct 180 NYGTDCPAAVVAWASRADEIVLRGTLADIAGRARAAGLTRTAVIIVGRALAAEGFRDSYL 239 Query 241 YSVARHG 247 YS R G Sbjct 240 YSRERFG 246 >gi|229493630|ref|ZP_04387415.1| precorrin-4 C11-methyltransferase [Rhodococcus erythropolis SK121] gi|229319591|gb|EEN85427.1| precorrin-4 C11-methyltransferase [Rhodococcus erythropolis SK121] Length=249 Score = 292 bits (747), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 154/246 (63%), Positives = 191/246 (78%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADLITVR QR++ PVCLYAGS++P +LL CP GA +VDT L+L+ Sbjct 1 MTVHFIGAGPGAADLITVRAQRIIAASPVCLYAGSLVPAELLEWCPVGAQVVDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I L +AD+ G DVARLHSGDPS++SA+AEQ R LDA G+ ++++PGVPAF AAAAAL Sbjct 61 EITAILVEADSAGLDVARLHSGDPSIFSAVAEQARRLDAAGVDFDMIPGVPAFTAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV+QT+ LTRV+TLST +P GEDL +L RS AT+V+HL A +I+ I L D Sbjct 121 GRELTVPGVSQTIVLTRVSTLSTAMPEGEDLRSLGRSGATMVIHLGAHRIEQIASELAD- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVAFAS P++ +RGTL I +H A IT+TAV++VG VLTAEGF DSYL Sbjct 180 NYGEDCPVAVVAFASRPEEIVVRGTLKTIVELVHAAGITKTAVVIVGRVLTAEGFPDSYL 239 Query 241 YSVARH 246 YS AR Sbjct 240 YSAARE 245 >gi|226306646|ref|YP_002766606.1| precorrin-4 C11-methyltransferase [Rhodococcus erythropolis PR4] gi|226185763|dbj|BAH33867.1| precorrin-4 C11-methyltransferase [Rhodococcus erythropolis PR4] Length=249 Score = 291 bits (744), Expect = 9e-77, Method: Compositional matrix adjust. Identities = 153/246 (63%), Positives = 191/246 (78%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADLITVR QR++ PVCLYAGS++P +LL CP GA +VDT L+L+ Sbjct 1 MTVHFIGAGPGAADLITVRAQRIIAASPVCLYAGSLVPAELLEWCPVGAQVVDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I L +A + G DVARLHSGDPS++SA+AEQ R LDA G+ ++++PGVPAF AAAAAL Sbjct 61 EITAILVEAHSAGLDVARLHSGDPSIFSAVAEQARRLDAAGVDFDMIPGVPAFTAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 +RELTVPGV+QT+ LTRV+TLST +P GEDL +L RS AT+V+HL A +I+ I L D Sbjct 121 RRELTVPGVSQTIVLTRVSTLSTAMPEGEDLRSLGRSGATMVVHLGAHRIEQIASELAD- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVAFAS P++ +RGTL I +H A IT+TAV++VG VLTAEGF DSYL Sbjct 180 NYGEDCPVAVVAFASRPEEIVVRGTLKTIVELVHAAGITKTAVVIVGRVLTAEGFPDSYL 239 Query 241 YSVARH 246 YS AR Sbjct 240 YSAARE 245 >gi|111221766|ref|YP_712560.1| precorrin-4 C11-methyltransferase [Frankia alni ACN14a] gi|111149298|emb|CAJ60984.1| Precorrin-4 C11-methyltransferase (Precorrin-3 methylase) [Frankia alni ACN14a] Length=269 Score = 290 bits (743), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 160/243 (66%), Positives = 192/243 (80%), Gaps = 1/243 (0%) Query 3 VYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQI 62 ++FIGAGPGAADLITVRG+ L+ CPVCLYAGS++P DLL+ CPPGA +VDT +TL+ I Sbjct 1 MHFIGAGPGAADLITVRGRDLIAACPVCLYAGSLVPADLLSHCPPGARLVDTARMTLDAI 60 Query 63 VRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKR 122 +L ADA G+DVARLHSGDPSLYSALAEQ R LDA G+ Y++ PGVPAFAAAAA+L+R Sbjct 61 TAELCAADAAGQDVARLHSGDPSLYSALAEQMRRLDAAGVPYDVTPGVPAFAAAAASLRR 120 Query 123 ELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDGGY 182 ELTVPGVAQ+V LTR A LS+P+PPGEDLA L RSRATLVLHLA +I+ +V L+ Y Sbjct 121 ELTVPGVAQSVVLTRTAVLSSPMPPGEDLATLGRSRATLVLHLAVHRIETLVEELVP-SY 179 Query 183 RPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYLYS 242 P+ P AVVA+AS + LRGTLADIAA+ A +T+TAVI+VG L A GF DS+LYS Sbjct 180 GPDCPAAVVAWASRSDEVVLRGTLADIAAQSRAAGLTKTAVIIVGRALAAAGFRDSFLYS 239 Query 243 VAR 245 R Sbjct 240 PQR 242 >gi|325676810|ref|ZP_08156483.1| precorrin-4 C(11)-methyltransferase [Rhodococcus equi ATCC 33707] gi|325552358|gb|EGD22047.1| precorrin-4 C(11)-methyltransferase [Rhodococcus equi ATCC 33707] Length=249 Score = 286 bits (732), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 150/245 (62%), Positives = 189/245 (78%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADLIT+R R++ + P CLYAGS++P +LL CP A ++DT L+L+ Sbjct 1 MTVHFIGAGPGAADLITLRASRIIAQSPACLYAGSLVPAELLTLCPDDAEVIDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I+ ++ DA G DVARLHSGDPS+YSA+AEQ R LDA G+ Y+IVPGVPAF AAAAAL Sbjct 61 EIIEQIIAFDAAGLDVARLHSGDPSIYSAVAEQVRRLDAAGVAYDIVPGVPAFTAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV+Q++ LTRV+TLST +PPGEDL +L RS AT+V+HL A +I+ IV L + Sbjct 121 GRELTVPGVSQSIVLTRVSTLSTAMPPGEDLRSLGRSGATMVVHLGAHRIEQIVEELSE- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVAFAS P + LRGTLA + ++H A IT+TAV++VG VL AEGF DSYL Sbjct 180 NYGSDCPAAVVAFASRPDEVVLRGTLATLVDQVHAAGITKTAVVIVGRVLAAEGFPDSYL 239 Query 241 YSVAR 245 YS R Sbjct 240 YSATR 244 >gi|333919695|ref|YP_004493276.1| Precorrin-4 C(11)-methyltransferase [Amycolicicoccus subflavus DQS3-9A1] gi|333481916|gb|AEF40476.1| Precorrin-4 C(11)-methyltransferase [Amycolicicoccus subflavus DQS3-9A1] Length=249 Score = 285 bits (729), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 159/245 (65%), Positives = 186/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQR + VCLYAGS++P +LL CP A VDT ++L Sbjct 1 MTVYFIGAGPGAADLITVRGQRRIAESAVCLYAGSLVPAELLDLCPENAVKVDTARMSLP 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 IV ++ AD DG DVAR+HSGDPS+YSA+AEQ R L+ GI YEIVPGVPAFAAAAAAL Sbjct 61 DIVERIIAADRDGHDVARVHSGDPSIYSAVAEQVRRLEQAGIEYEIVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV QTV L+R+A +T +PPGE+L LA++R TLVLHLA ID +V LL Sbjct 121 GRELTVPGVGQTVILSRIAVDATAMPPGEELRNLAQTRTTLVLHLAVGHIDRVVSELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y P+ PVAVVAFAS P ++ +RGTL IA +H +I RTAVI+VG VL AEGF DSYL Sbjct 180 SYGPDCPVAVVAFASRPDEKIVRGTLGTIADAVHAQEIRRTAVIIVGRVLAAEGFPDSYL 239 Query 241 YSVAR 245 YSVAR Sbjct 240 YSVAR 244 >gi|295835352|ref|ZP_06822285.1| precorrin-4 C(11)-methyltransferase [Streptomyces sp. SPB74] gi|295825437|gb|EFG64245.1| precorrin-4 C(11)-methyltransferase [Streptomyces sp. SPB74] Length=249 Score = 283 bits (725), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 160/245 (66%), Positives = 185/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLIT+RG R L RCPVCLYAGS++P +LLA+CPPGA +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITLRGARTLARCPVCLYAGSLVPAELLAECPPGARLVDTAHLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 I + + A +G+DVARLHSGDP+++SA+AEQ R LDALGI YE+VPGVPAFAA AAAL Sbjct 61 AITAEFSRAHENGQDVARLHSGDPAVFSAVAEQMRRLDALGIPYEVVPGVPAFAAVAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTRVA +TP+P GEDLA L RS A LVLHLAA +D + LL Sbjct 121 KRELTVPTVGQTVVLTRVAQEATPMPEGEDLATLGRSGALLVLHLAARYVDRVTAELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA AS P++ LRGTL IAA A ITRTAVI+VG L A F DS+L Sbjct 180 HYGADCPAAVVAHASRPEELILRGTLGTIAAETKAAGITRTAVIMVGRTLGASSFRDSHL 239 Query 241 YSVAR 245 YS AR Sbjct 240 YSAAR 244 >gi|312139739|ref|YP_004007075.1| precorrin-4 c11-methyltransferase cobm [Rhodococcus equi 103S] gi|311889078|emb|CBH48391.1| precorrin-4 C11-methyltransferase CobM [Rhodococcus equi 103S] Length=249 Score = 283 bits (725), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 149/245 (61%), Positives = 187/245 (77%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADLIT+R R++ + P CLYAGS++P LL CP A ++DT L+L+ Sbjct 1 MTVHFIGAGPGAADLITLRASRIIAQSPACLYAGSLVPAGLLTLCPDDAEVIDTARLSLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I+ ++ DA G DVARLHSGDPS+YSA+AEQ R LD G+ Y+IVPGVPAF AAAAAL Sbjct 61 EIIEQIIAFDAAGLDVARLHSGDPSIYSAVAEQVRRLDVAGVAYDIVPGVPAFTAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVPGV+Q++ LTRV+TLST +PPGEDL +L RS AT+V+HL A +I+ IV L + Sbjct 121 GRELTVPGVSQSIVLTRVSTLSTAMPPGEDLRSLGRSGATMVVHLGAHRIEQIVEELSE- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVAFAS P + LRGTLA + ++H A IT+TAV++VG VL AEGF DSYL Sbjct 180 NYGSDCPAAVVAFASRPDEVVLRGTLATLVDQVHAAGITKTAVVIVGRVLAAEGFPDSYL 239 Query 241 YSVAR 245 YS R Sbjct 240 YSATR 244 >gi|337290707|ref|YP_004629728.1| precorrin-4 C11-methyltransferase [Corynebacterium ulcerans BR-AD22] gi|334696820|gb|AEG81617.1| precorrin-4 C11-methyltransferase [Corynebacterium ulcerans 809] gi|334699013|gb|AEG83809.1| precorrin-4 C11-methyltransferase [Corynebacterium ulcerans BR-AD22] Length=257 Score = 283 bits (724), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 142/245 (58%), Positives = 189/245 (78%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADL+T+R Q+L+ C VC+YAGSI+P ++L P A +++T + L+ Sbjct 1 MTVYFIGAGPGAADLLTLRAQKLISTCQVCMYAGSIVPAEVLDSVPDNAEVINTARMPLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I +++ DA A+G+D+ARLHSGDP++YSA+AEQ R L A G+ Y+IVPGVP+FAA AAAL Sbjct 61 EITQRILDAHAEGKDIARLHSGDPAIYSAVAEQARRLTAHGVDYQIVPGVPSFAAVAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVP V QTV LTRV+ ++ +P GEDL+ L +S ATL +HLAA ID +V L+ Sbjct 121 GHELTVPTVGQTVILTRVSGRASAMPEGEDLSTLGQSGATLCIHLAAHDIDRVVAELIP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVAFAS P+++ +RGTLAD+A ++ ++ ITRTA+IVVG VLTAEGF DS+L Sbjct 180 NYGEDCPVAVVAFASRPEEKIVRGTLADVAIKVKESGITRTAIIVVGRVLTAEGFPDSFL 239 Query 241 YSVAR 245 YS R Sbjct 240 YSDGR 244 >gi|311899846|dbj|BAJ32254.1| putative precorrin-4 C11-methyltransferase [Kitasatospora setae KM-6054] Length=246 Score = 282 bits (721), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 159/245 (65%), Positives = 187/245 (77%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRGQR L RC VCLYAGS++P +LLA CPP A +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGQRTLGRCGVCLYAGSLVPPELLADCPPDARLVDTANLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI+ ++ A +G+DVARLHSGDPS++SA+AEQ R LDA I YE+VPGVPAFAAAAAAL Sbjct 61 QILAEIVRAHGEGQDVARLHSGDPSVFSAMAEQMRRLDAADIPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTRVA +TP+PPGE+L L +S A LVLHLAA +D++V LL Sbjct 121 KRELTVPTVGQTVILTRVARQATPMPPGEELDVLGKSGALLVLHLAARYVDSVVEELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y P+ P AVVA AS P + LRGTL DIA ++ A + RTAVI+VG L A F DS+L Sbjct 180 HYGPDCPAAVVAMASRPDELVLRGTLGDIAVQVKAAGVLRTAVIIVGQTLAATEFRDSHL 239 Query 241 YSVAR 245 YS AR Sbjct 240 YSTAR 244 >gi|300858445|ref|YP_003783428.1| precorrin-4 C11-methyltransferase [Corynebacterium pseudotuberculosis FRC41] gi|300685899|gb|ADK28821.1| precorrin-4 C11-methyltransferase [Corynebacterium pseudotuberculosis FRC41] gi|302206158|gb|ADL10500.1| Precorrin-4 C11-methyltransferase [Corynebacterium pseudotuberculosis C231] gi|302330715|gb|ADL20909.1| Precorrin-4 C11-methyltransferase [Corynebacterium pseudotuberculosis 1002] gi|308276398|gb|ADO26297.1| Precorrin-4 C11-methyltransferase [Corynebacterium pseudotuberculosis I19] gi|341824837|gb|AEK92358.1| Precorrin-4 C11-methyltransferase [Corynebacterium pseudotuberculosis PAT10] Length=257 Score = 281 bits (719), Expect = 6e-74, Method: Compositional matrix adjust. Identities = 143/252 (57%), Positives = 192/252 (77%), Gaps = 5/252 (1%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADL+T+R Q+L+ C VC+YAGSI+P ++L P A +++T + L+ Sbjct 1 MTVYFIGAGPGAADLLTLRAQKLISTCQVCMYAGSIVPPEVLDSVPEHAEVINTARMPLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I +++ DA + G+D+ARLHSGDP++YSA+AEQ R L A G+ Y+IVPGVP+FAA AAAL Sbjct 61 EITQRILDAHSQGKDIARLHSGDPAIYSAVAEQARRLTAHGVDYQIVPGVPSFAAVAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVP V QTV LTRV+ ++ +P GEDL+ L +S ATL +HLAA ID +V L+ Sbjct 121 GHELTVPTVGQTVILTRVSGRASAMPEGEDLSTLGQSGATLCIHLAAHDIDRVVAELIP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVAFAS P+++ +RGTL+D+A+++ ++ ITRTA+IVVG VLTAEGF DS+L Sbjct 180 NYGEDCPVAVVAFASRPEEKIVRGTLSDVASKVKESGITRTAIIVVGRVLTAEGFPDSFL 239 Query 241 YSVAR----HGR 248 YS R HGR Sbjct 240 YSDDRPRDTHGR 251 >gi|302537652|ref|ZP_07289994.1| precorrin-4 C11-methyltransferase [Streptomyces sp. C] gi|302446547|gb|EFL18363.1| precorrin-4 C11-methyltransferase [Streptomyces sp. C] Length=249 Score = 281 bits (719), Expect = 7e-74, Method: Compositional matrix adjust. Identities = 163/245 (67%), Positives = 186/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L PVCLYAGS++P +LLA+CP GA +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLAAAPVCLYAGSLVPRELLAECPDGARLVDTSQLNLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I+ + A A G DVARLHSGDPS++SA+AEQ R LDA GI YE+VPGVPAFAAAAAAL Sbjct 61 EIIAECVRAHAAGLDVARLHSGDPSIFSAVAEQMRRLDAAGIPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTR+A +TP+PPGEDLA L RS A LVLHLA +D +V LL Sbjct 121 KRELTVPTVGQTVILTRIAQQATPMPPGEDLATLGRSGALLVLHLATRYVDRVVDELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y E PVAVVA AS P + LRGTLADIAA++ A + RTAVIVVG L AE F DS+L Sbjct 180 HYGAECPVAVVAMASRPDELILRGTLADIAAQVKAAGLVRTAVIVVGRTLGAEQFRDSHL 239 Query 241 YSVAR 245 YS R Sbjct 240 YSPER 244 >gi|318059049|ref|ZP_07977772.1| precorrin-4 C11-methyltransferase [Streptomyces sp. SA3_actG] gi|318078133|ref|ZP_07985465.1| precorrin-4 C11-methyltransferase [Streptomyces sp. SA3_actF] Length=249 Score = 280 bits (717), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 161/245 (66%), Positives = 184/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLIT+RG R L RCPVCLYAGS++P +LLA+CPP A +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITLRGARTLARCPVCLYAGSLVPAELLAECPPDARLVDTAHLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 I + + A G+DVARLHSGDPS++SA+AEQ R LDALGI YE+VPGVPAFAAAAAAL Sbjct 61 AITAEFSRAHEAGQDVARLHSGDPSVFSAVAEQMRRLDALGIPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTRVA +TP+P GEDLA L RS A LVLHLAA +D + LL Sbjct 121 KRELTVPTVGQTVVLTRVAQEATPMPEGEDLATLGRSGALLVLHLAARYVDRVTAELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA AS P++ LRGTL IAA A ITRTAVI+VG L A F DS+L Sbjct 180 HYGADCPAAVVAHASRPEELILRGTLGTIAAETKAAGITRTAVIMVGRTLGASSFRDSHL 239 Query 241 YSVAR 245 YS AR Sbjct 240 YSAAR 244 >gi|297194619|ref|ZP_06912017.1| precorrin-4 C11-methyltransferase [Streptomyces pristinaespiralis ATCC 25486] gi|297152357|gb|EFH31692.1| precorrin-4 C11-methyltransferase [Streptomyces pristinaespiralis ATCC 25486] Length=260 Score = 280 bits (716), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 159/245 (65%), Positives = 184/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L C VCLYAGS++P +LLA CPP A ++DT L L+ Sbjct 11 MTVYFIGAGPGAADLITVRGARTLASCGVCLYAGSLVPRELLADCPPDARLIDTAQLDLD 70 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 I +L A +G +VARLHSGDPS++SA+AEQ R LDA G+ YE+VPGVPAFAAAAAAL Sbjct 71 AITAELVRAHEEGHEVARLHSGDPSVFSAVAEQMRRLDAAGVPYEVVPGVPAFAAAAAAL 130 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTRVA +TP+P GEDLA L RS A LVLHL A +D IV LL Sbjct 131 KRELTVPTVGQTVILTRVAQQATPMPDGEDLATLGRSGALLVLHLGARHVDRIVSELLP- 189 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA AS P + LRGTL DIAA++ +A +TRTAVI+VG VL A GF DS+L Sbjct 190 HYGADCPAAVVAMASRPDELVLRGTLEDIAAQVKEAGVTRTAVILVGRVLAASGFRDSHL 249 Query 241 YSVAR 245 YS R Sbjct 250 YSAER 254 >gi|328883574|emb|CCA56813.1| Cobalt-precorrin-4 C11-methyltransferase [Streptomyces venezuelae ATCC 10712] Length=249 Score = 279 bits (714), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 159/245 (65%), Positives = 187/245 (77%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L C VCLYAGS++P +LLA+CPP A +VDT + L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLASCGVCLYAGSLVPTELLAECPPEAKLVDTARMDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIV ++A A G+DVARLHSGDPS++SA+AEQ R LDALGI YE+VPGVPAFAAAAAAL Sbjct 61 QIVAEIAAAHRAGQDVARLHSGDPSVFSAMAEQMRRLDALGIPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTR+A +TP+P GEDLA L RS A LVLHLAA +D +V L+ Sbjct 121 KRELTVPTVGQTVILTRIAQQATPMPEGEDLATLGRSGALLVLHLAARYVDRVVDELVP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA AS P + LRGTL DIAA++ +A IT+TAVI+VG L A F DS+L Sbjct 180 HYGADCPAAVVAMASRPDEIVLRGTLEDIAAQLKEAGITKTAVILVGRTLAASQFRDSHL 239 Query 241 YSVAR 245 Y R Sbjct 240 YDPER 244 >gi|297155179|gb|ADI04891.1| precorrin-4 C11-methyltransferase [Streptomyces bingchenggensis BCW-1] Length=247 Score = 278 bits (712), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 159/246 (65%), Positives = 184/246 (75%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L RC VCLYAGS++P +LLA+CPP A +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLARCRVCLYAGSLVPRELLAECPPDARLVDTARLNLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI +L A G DVARLHSGDPS++SA+AEQ R LDA G+ YE++PGVPAFAAAAAAL Sbjct 61 QITDELVRAHQAGEDVARLHSGDPSVFSAVAEQMRRLDAHGVPYEVIPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 RELTVP V QTV LTRVA +TP+P GEDLA L RSRA +VLHLAA +D +V LL Sbjct 121 GRELTVPTVGQTVVLTRVAQQATPMPDGEDLATLGRSRALIVLHLAARYVDRVVAELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA AS P + LRGTL DIA R+ +A + RTAVI+VG L AE F DS+L Sbjct 180 HYGADCPAAVVARASRPDELVLRGTLGDIADRVKEAGVVRTAVIMVGRTLGAEQFRDSHL 239 Query 241 YSVARH 246 YS R Sbjct 240 YSARRE 245 >gi|333022913|ref|ZP_08450977.1| putative precorrin-4 C(11)-methyltransferase [Streptomyces sp. Tu6071] gi|332742765|gb|EGJ73206.1| putative precorrin-4 C(11)-methyltransferase [Streptomyces sp. Tu6071] Length=247 Score = 278 bits (710), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 159/243 (66%), Positives = 183/243 (76%), Gaps = 1/243 (0%) Query 3 VYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQI 62 +YFIGAGPGAADLIT+RG R L RCPVCLYAGS++P +LLA+CPPGA +VDT L L+ I Sbjct 1 MYFIGAGPGAADLITLRGARTLARCPVCLYAGSLVPAELLAECPPGARLVDTAHLDLDAI 60 Query 63 VRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKR 122 + + A G+DVARLHSGDPS++SA+AEQ R LDALGI YE+VPGVPAFAAAAAALKR Sbjct 61 TAEFSRAHEAGQDVARLHSGDPSVFSAVAEQMRRLDALGIPYEVVPGVPAFAAAAAALKR 120 Query 123 ELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDGGY 182 ELTVP V QTV LTRVA +TP+P GEDLA L RS A LVLHLAA +D + LL Y Sbjct 121 ELTVPTVGQTVVLTRVAQEATPMPEGEDLATLGRSGALLVLHLAARYVDRVTAELLP-HY 179 Query 183 RPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYLYS 242 + P AVVA AS P++ LRGTL IAA A ITRTAVI+VG L A F DS+LYS Sbjct 180 GADCPAAVVAHASRPEELILRGTLGTIAAETRAAGITRTAVILVGRTLGASSFRDSHLYS 239 Query 243 VAR 245 AR Sbjct 240 AAR 242 >gi|271966897|ref|YP_003341093.1| precorrin-4 C(11)-methyltransferase [Streptosporangium roseum DSM 43021] gi|270510072|gb|ACZ88350.1| Precorrin-4 C(11)-methyltransferase [Streptosporangium roseum DSM 43021] Length=247 Score = 278 bits (710), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 154/245 (63%), Positives = 186/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV FIGAGPGAADLIT+RGQR + PVCLYAGS++P +LL CP GA +VDT + LE Sbjct 1 MTVRFIGAGPGAADLITLRGQRAVASSPVCLYAGSLVPAELLECCPRGARLVDTARMALE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +IV ++ A G DVARLHSGDPS++SA+AEQ R LDA G+ YE++PGVPAFAAAAA+L Sbjct 61 EIVAEMLAAHGAGHDVARLHSGDPSVFSAMAEQMRRLDAAGVPYEVIPGVPAFAAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGV QT+ LTR + +TP+P GEDL L RSRAT+VLHLA +I+A+ L+ Sbjct 121 KRELTVPGVGQTIVLTRTSVRATPMPDGEDLDTLGRSRATMVLHLAVQRIEAVAAELVP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVA AS + LRGTLADIA ++H A + RTAVIVVG VLTA F DS+L Sbjct 180 NYGADCPVAVVARASRDDEVILRGTLADIAGKVHAAGVVRTAVIVVGRVLTASEFPDSHL 239 Query 241 YSVAR 245 YS AR Sbjct 240 YSAAR 244 >gi|213965555|ref|ZP_03393749.1| precorrin-4 C11-methyltransferase [Corynebacterium amycolatum SK46] gi|213951714|gb|EEB63102.1| precorrin-4 C11-methyltransferase [Corynebacterium amycolatum SK46] Length=257 Score = 276 bits (707), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 152/252 (61%), Positives = 184/252 (74%), Gaps = 5/252 (1%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADL+T+R RL++ CPVCLYAGSI+P ++L CP GA I++T + L+ Sbjct 1 MTVYFIGAGPGAADLLTLRADRLIRSCPVCLYAGSIVPPEVLENCPEGAEIINTARMPLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 I+ + A A G+DVARL SGDPS++SALAEQ R L LGI YEIVPGVPAF+AAAAAL Sbjct 61 TIIETIQAAHAAGKDVARLQSGDPSVWSALAEQVRRLSELGIDYEIVPGVPAFSAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVP V Q+V LTR++ ++ +P GE L R+ ATL +HLAA ID +V L Sbjct 121 GHELTVPTVGQSVVLTRISGRASKMPEGETLENFGRTGATLCIHLAAHDIDRVVEELTP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y PVAVVAFAS P+Q LRGTL+DIA ++ DA +TRTAVI+VG VLTAE F DSYL Sbjct 180 HYGEHGPVAVVAFASRPEQVILRGTLSDIAQQVKDAGVTRTAVIIVGKVLTAEAFPDSYL 239 Query 241 YSVAR----HGR 248 YS R HGR Sbjct 240 YSDDRPRDEHGR 251 >gi|256375913|ref|YP_003099573.1| precorrin-4 C11-methyltransferase [Actinosynnema mirum DSM 43827] gi|255920216|gb|ACU35727.1| precorrin-4 C11-methyltransferase [Actinosynnema mirum DSM 43827] Length=250 Score = 276 bits (705), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 155/245 (64%), Positives = 187/245 (77%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADL+TVR + + PVCLYAG+++P +L CPPGA +VDT LTL+ Sbjct 1 MTVHFIGAGPGAADLLTVRAVQRITTSPVCLYAGALVPVAVLEHCPPGAKLVDTANLTLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +IV +L +A G DVARLHSGDPS++SA+AEQ R LDA G+ YE+VPGVPAFAAAAAAL Sbjct 61 EIVHELVEAHRAGHDVARLHSGDPSVFSAVAEQARRLDAEGVPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVPGV QTV LTR + +TP+P GEDLA L SRAT+VLHLA +I+ +V L Sbjct 121 KRELTVPGVGQTVVLTRTSARATPMPEGEDLATLGASRATMVLHLAVQRIEEVVADLAP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVA AS + LRGTLADIA ++ +A + RTAVIVVG VL AEGF DS+L Sbjct 180 NYGADCPVAVVARASREDELVLRGTLADIAGQVREAGVRRTAVIVVGRVLAAEGFPDSHL 239 Query 241 YSVAR 245 YS AR Sbjct 240 YSAAR 244 >gi|290955554|ref|YP_003486736.1| precorrin-4 C11-methyltransferase [Streptomyces scabiei 87.22] gi|260645080|emb|CBG68166.1| precorrin-4 C11-methyltransferase [Streptomyces scabiei 87.22] Length=249 Score = 274 bits (701), Expect = 8e-72, Method: Compositional matrix adjust. Identities = 156/245 (64%), Positives = 184/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L C VCLYAGS++P +LLA+CPPGA +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLAACGVCLYAGSLVPRELLAECPPGARLVDTAQLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI +L A +G DVARLHSGDPS++SA+AEQ R LDA G+ YE+VPGVPAFAAAAAAL Sbjct 61 QITAELVRAHEEGHDVARLHSGDPSVFSAVAEQMRRLDAAGVPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTRVA +TP+P GEDLA L RS A +VLHLA +D +V LL Sbjct 121 KRELTVPTVGQTVILTRVAQQATPMPDGEDLATLGRSGALIVLHLAVRYVDRVVEELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA+AS P++ LRGTL +IA ++ A + RTAVI+VG L A F DS+L Sbjct 180 HYGADCPAAVVAYASRPEELVLRGTLEEIAGQVKAAGVLRTAVIMVGRTLGARQFRDSHL 239 Query 241 YSVAR 245 YS R Sbjct 240 YSPER 244 >gi|305680827|ref|ZP_07403634.1| precorrin-4 C(11)-methyltransferase [Corynebacterium matruchotii ATCC 14266] gi|305659032|gb|EFM48532.1| precorrin-4 C(11)-methyltransferase [Corynebacterium matruchotii ATCC 14266] Length=257 Score = 273 bits (699), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 144/242 (60%), Positives = 182/242 (76%), Gaps = 1/242 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADL+T+R RL++ C +CLYAGSI+PD++LA P GA +++T + LE Sbjct 1 MTVYFIGAGPGAADLLTLRADRLIRTCDMCLYAGSIVPDEVLAHTPEGAEVINTARMPLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I+ + AD++G+++ARLHSGDP+LYSA+AEQ R L GI YEIVPGVPAF+AAAA+L Sbjct 61 EIIATIIRADSEGKNIARLHSGDPTLYSAVAEQIRRLTEAGIAYEIVPGVPAFSAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVP V QTV LTRV+ ++ +P GEDL L S AT+V+HLAA I +V L Sbjct 121 GHELTVPTVGQTVILTRVSGRASAMPEGEDLPTLGASGATMVIHLAAHDIRRVVAELTP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y P+ PVAVVAFAS P + +RGTLADIA ++ A ITRTAVI+VG VL A F DS+L Sbjct 180 NYGPDCPVAVVAFASRPAEVIVRGTLADIAEQVELAGITRTAVIIVGRVLQATEFPDSFL 239 Query 241 YS 242 YS Sbjct 240 YS 241 >gi|345011364|ref|YP_004813718.1| precorrin-4 C11-methyltransferase [Streptomyces violaceusniger Tu 4113] gi|344037713|gb|AEM83438.1| precorrin-4 C11-methyltransferase [Streptomyces violaceusniger Tu 4113] Length=256 Score = 273 bits (698), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 158/246 (65%), Positives = 183/246 (75%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L RC VCLYAGS++P +LLA+CPP A +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLARCQVCLYAGSLVPRELLAECPPDARLVDTARLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI + A G DVARLHSGDPS++SA+AEQ R LDA G+ Y++VPGVPAFAAAAAAL Sbjct 61 QITAEFVAAHKAGHDVARLHSGDPSVFSAVAEQMRRLDAAGVPYDVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTR+A +TP+P GEDLA L RS A LVLHLAA +D +V LL Sbjct 121 KRELTVPTVGQTVILTRIAQQATPMPEGEDLATLGRSGALLVLHLAARYVDRVVGELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA AS P + LRGTL DIAA++ A + RTAVI+VG L AE F DS+L Sbjct 180 HYGADCPAAVVAMASRPDELVLRGTLDDIAAQVKAAGVVRTAVIIVGRTLGAEQFRDSHL 239 Query 241 YSVARH 246 YS R Sbjct 240 YSPDRE 245 >gi|225021469|ref|ZP_03710661.1| hypothetical protein CORMATOL_01489 [Corynebacterium matruchotii ATCC 33806] gi|224945851|gb|EEG27060.1| hypothetical protein CORMATOL_01489 [Corynebacterium matruchotii ATCC 33806] Length=257 Score = 273 bits (697), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 144/242 (60%), Positives = 182/242 (76%), Gaps = 1/242 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADL+T+R RL++ C +CLYAGSI+PD++LA P GA +++T + LE Sbjct 1 MTVYFIGAGPGAADLLTLRADRLIRTCDMCLYAGSIVPDEVLAHTPEGAEVINTARMPLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 +I+ + AD++G+++ARLHSGDP+LYSA+AEQ R L GI YEIVPGVPAF+AAAA+L Sbjct 61 EIIATIIRADSEGKNIARLHSGDPTLYSAVAEQIRRLTEAGITYEIVPGVPAFSAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 ELTVP V QTV LTRV+ ++ +P GEDL L S AT+V+HLAA I +V L Sbjct 121 GHELTVPTVGQTVILTRVSGRASAMPEGEDLPTLGASGATMVIHLAAHDIRRVVAELTP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y P+ PVAVVAFAS P + +RGTLADIA ++ A ITRTAVI+VG VL A F DS+L Sbjct 180 NYGPDCPVAVVAFASRPAEVIVRGTLADIAEQVELAGITRTAVIIVGRVLQATEFPDSFL 239 Query 241 YS 242 YS Sbjct 240 YS 241 >gi|300788885|ref|YP_003769176.1| precorrin-4 C11-methyltransferase [Amycolatopsis mediterranei U32] gi|299798399|gb|ADJ48774.1| precorrin-4 C11-methyltransferase [Amycolatopsis mediterranei U32] gi|340530509|gb|AEK45714.1| precorrin-4 C11-methyltransferase [Amycolatopsis mediterranei S699] Length=253 Score = 272 bits (695), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 147/245 (60%), Positives = 176/245 (72%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTV+FIGAGPGAADLITVRG+ LL RC VCLY GS+ P DLLA CPPGA +VDT L+LE Sbjct 1 MTVHFIGAGPGAADLITVRGRDLLARCGVCLYPGSMTPPDLLAYCPPGAELVDTANLSLE 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QIV KL +A G +VARL SGDPSLYSA+AEQ R LDA G+ Y +VPGVPAFAA+AA L Sbjct 61 QIVAKLVEAHRAGHEVARLCSGDPSLYSAVAEQVRRLDAAGVPYAVVPGVPAFAASAAVL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP + Q++ +TRV ST +PPGE LAA A + ATL LHLA ++ + L Sbjct 121 KRELTVPEIGQSLVITRVQARSTKMPPGETLAAFAATGATLALHLAVNHVERVAEELTP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + PVAVVA AS P + +RG L ++ A + +A +TR A I VG VL A F DS+L Sbjct 180 HYGEDCPVAVVALASQPGETVVRGVLGELPALVREAGMTRAATIFVGRVLAATDFPDSFL 239 Query 241 YSVAR 245 YS AR Sbjct 240 YSSAR 244 >gi|337763716|emb|CCB72426.1| Precorrin-4 C(11)-methyltransferase [Streptomyces cattleya NRRL 8057] Length=249 Score = 271 bits (694), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 155/245 (64%), Positives = 184/245 (76%), Gaps = 1/245 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L C VCLYAGS++P +LLA+CPP A +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLAACRVCLYAGSLVPRELLAECPPDARLVDTARLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI +L A +G DVARLHSGDPS++SA+AEQ R LDA G+ YE+VPGVPAFAAAAAAL Sbjct 61 QITAELVRAHQEGHDVARLHSGDPSVFSAVAEQMRRLDAAGVPYEVVPGVPAFAAAAAAL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V QTV LTRVA +T +P GEDLA L R A +VLHLAA +D +V LL Sbjct 121 KRELTVPTVGQTVILTRVAQRATAMPDGEDLATLGRGGALIVLHLAARYVDRVVGELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA+AS P + +RGTLA+IA ++ +A + RTAVI+VG L AE F DS+L Sbjct 180 HYGADCPAAVVAYASRPDELVIRGTLAEIAGKVKEAGVVRTAVIMVGRTLGAEHFRDSHL 239 Query 241 YSVAR 245 YS R Sbjct 240 YSPER 244 >gi|302554737|ref|ZP_07307079.1| precorrin-4 C11-methyltransferase [Streptomyces viridochromogenes DSM 40736] gi|302472355|gb|EFL35448.1| precorrin-4 C11-methyltransferase [Streptomyces viridochromogenes DSM 40736] Length=249 Score = 270 bits (691), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 153/246 (63%), Positives = 183/246 (75%), Gaps = 1/246 (0%) Query 1 MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE 60 MTVYFIGAGPGAADLITVRG R L C VCLYAGS++P +LLA+CPP A +VDT L L+ Sbjct 1 MTVYFIGAGPGAADLITVRGARTLAACRVCLYAGSLVPRELLAECPPDARLVDTAQLDLD 60 Query 61 QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL 120 QI +L A +G DVARLHSGDPS++SA+AEQ R LDA G+ YE+VPGVPAFAAAAA+L Sbjct 61 QITAELLRAHEEGHDVARLHSGDPSVFSAVAEQMRRLDAAGVPYEVVPGVPAFAAAAASL 120 Query 121 KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG 180 KRELTVP V Q+V LTRVA +T +P GEDLA L RS A +VLHLAA D +V LL Sbjct 121 KRELTVPTVGQSVILTRVANRATAMPEGEDLATLGRSGALIVLHLAARYADRVVEELLP- 179 Query 181 GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL 240 Y + P AVVA+AS P + +RGTL +IA ++ +A + RTAVI+VG L AE F DS+L Sbjct 180 HYGADCPAAVVAYASRPDEIVIRGTLEEIAGKVKEAGVLRTAVIMVGRTLGAEQFRDSHL 239 Query 241 YSVARH 246 YS R Sbjct 240 YSPERE 245 Lambda K H 0.321 0.136 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 362093846100 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40