BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2124c Length=1192 Score E Sequences producing significant alignments: (Bits) Value gi|15609261|ref|NP_216640.1| 5-methyltetrahydrofolate--homocyste... 2429 0.0 gi|31793304|ref|NP_855797.1| 5-methyltetrahydrofolate--homocyste... 2429 0.0 gi|298525620|ref|ZP_07013029.1| methionine synthase [Mycobacteri... 2427 0.0 gi|289745397|ref|ZP_06504775.1| 5-methyltetrahydrofolate-homocys... 2427 0.0 gi|289447744|ref|ZP_06437488.1| 5-methyltetrahydrofolate-homocys... 2426 0.0 gi|254551156|ref|ZP_05141603.1| 5-methyltetrahydrofolate-homocys... 2426 0.0 gi|294993532|ref|ZP_06799223.1| 5-methyltetrahydrofolate-homocys... 2425 0.0 gi|289754232|ref|ZP_06513610.1| Methionine synthase [Mycobacteri... 2291 0.0 gi|240171403|ref|ZP_04750062.1| 5-methyltetrahydrofolate-homocys... 2289 0.0 gi|289570237|ref|ZP_06450464.1| 5-methyltetrahydrofolate-homocys... 2199 0.0 gi|15827677|ref|NP_301940.1| 5-methyltetrahydrofolate-homocystei... 2172 0.0 gi|4200262|emb|CAA22918.1| putative 5-methyltetrahydrofolate-hom... 2138 0.0 gi|54025162|ref|YP_119404.1| putative 5-methyltetrahydrofolate:h... 1996 0.0 gi|343927957|ref|ZP_08767423.1| methionine synthase [Gordonia al... 1934 0.0 gi|111017878|ref|YP_700850.1| methionine synthase [Rhodococcus j... 1930 0.0 gi|226360011|ref|YP_002777789.1| methionine synthase [Rhodococcu... 1928 0.0 gi|312139705|ref|YP_004007041.1| methionine synthase meth [Rhodo... 1927 0.0 gi|325676845|ref|ZP_08156518.1| 5-methyltetrahydrofolate-homocys... 1926 0.0 gi|226306676|ref|YP_002766636.1| methionine synthase [Rhodococcu... 1915 0.0 gi|333919631|ref|YP_004493212.1| methionine synthase [Amycolicic... 1891 0.0 gi|262202371|ref|YP_003273579.1| methionine synthase [Gordonia b... 1874 0.0 gi|256376339|ref|YP_003099999.1| methionine synthase [Actinosynn... 1782 0.0 gi|25028193|ref|NP_738247.1| putative 5-methyltetrahydrofolate--... 1777 0.0 gi|134100433|ref|YP_001106094.1| putative 5-methyltetrahydrofola... 1766 0.0 gi|19552721|ref|NP_600723.1| methionine synthase I cobalamin-bin... 1764 0.0 gi|344045037|gb|EGV40711.1| methionine synthase I cobalamin-bind... 1762 0.0 gi|145295640|ref|YP_001138461.1| hypothetical protein cgR_1567 [... 1762 0.0 gi|331697130|ref|YP_004333369.1| methionine synthase [Pseudonoca... 1761 0.0 gi|62390389|ref|YP_225791.1| homocysteine methyltransferase [Cor... 1752 0.0 gi|257056681|ref|YP_003134513.1| methionine synthase (B12-depend... 1738 0.0 gi|300786796|ref|YP_003767087.1| 5-methyltetrahydrofolate--homoc... 1707 0.0 gi|302206179|gb|ADL10521.1| Methionine synthase [Corynebacterium... 1704 0.0 gi|300858469|ref|YP_003783452.1| 5-methyltetrahydrofolate--homoc... 1704 0.0 gi|334696843|gb|AEG81640.1| 5-methyltetrahydrofolate--homocystei... 1701 0.0 gi|305681089|ref|ZP_07403896.1| methionine synthase [Corynebacte... 1697 0.0 gi|225021445|ref|ZP_03710637.1| hypothetical protein CORMATOL_01... 1693 0.0 gi|337290730|ref|YP_004629751.1| 5-methyltetrahydrofolate--homoc... 1693 0.0 gi|38233847|ref|NP_939614.1| 5-methyltetrahydrofolate--homocyste... 1692 0.0 gi|319949268|ref|ZP_08023348.1| putative 5-methyltetrahydrofolat... 1690 0.0 gi|258652965|ref|YP_003202121.1| methionine synthase [Nakamurell... 1674 0.0 gi|213965602|ref|ZP_03393796.1| methionine synthase [Corynebacte... 1674 0.0 gi|237785511|ref|YP_002906216.1| 5-methyltetrahydrofolate--homoc... 1667 0.0 gi|336325590|ref|YP_004605556.1| 5-methyltetrahydrofolate-homocy... 1654 0.0 gi|72162224|ref|YP_289881.1| methionine synthase (B12-dependent)... 1623 0.0 gi|330468543|ref|YP_004406286.1| methionine synthase [Verrucosis... 1609 0.0 gi|323719336|gb|EGB28477.1| 5-methyltetrahydrofolate-homocystein... 1608 0.0 gi|345013971|ref|YP_004816325.1| methionine synthase [Streptomyc... 1606 0.0 gi|271967199|ref|YP_003341395.1| methionine synthase [Streptospo... 1603 0.0 gi|315506202|ref|YP_004085089.1| methionine synthase [Micromonos... 1598 0.0 gi|302867394|ref|YP_003836031.1| methionine synthase [Micromonos... 1597 0.0 >gi|15609261|ref|NP_216640.1| 5-methyltetrahydrofolate--homocystein methyltransferase [Mycobacterium tuberculosis H37Rv] gi|148661939|ref|YP_001283462.1| hypothetical protein MRA_2139 [Mycobacterium tuberculosis H37Ra] gi|148823335|ref|YP_001288089.1| 5-methyltetrahydrofolate-homocystein methyltransferase metH [Mycobacterium tuberculosis F11] 31 more sequence titles Length=1192 Score = 2429 bits (6295), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1191/1192 (99%), Positives = 1192/1192 (100%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|31793304|ref|NP_855797.1| 5-methyltetrahydrofolate--homocystein methyltransferase [Mycobacterium bovis AF2122/97] gi|121638006|ref|YP_978230.1| putative 5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (MS) [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990500|ref|YP_002645187.1| putative 5-methyltetrahydrofolate--homocystein methyltransferase [Mycobacterium bovis BCG str. Tokyo 172] 6 more sequence titles Length=1192 Score = 2429 bits (6294), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1190/1192 (99%), Positives = 1192/1192 (100%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDI+LSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIVLSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|298525620|ref|ZP_07013029.1| methionine synthase [Mycobacterium tuberculosis 94_M4241A] gi|298495414|gb|EFI30708.1| methionine synthase [Mycobacterium tuberculosis 94_M4241A] Length=1192 Score = 2427 bits (6290), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1190/1192 (99%), Positives = 1191/1192 (99%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAE YQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAETYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|289745397|ref|ZP_06504775.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis 02_1987] gi|289685925|gb|EFD53413.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis 02_1987] Length=1192 Score = 2427 bits (6289), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1190/1192 (99%), Positives = 1191/1192 (99%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKK H Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKHH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|289447744|ref|ZP_06437488.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis CPHL_A] gi|289420702|gb|EFD17903.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis CPHL_A] Length=1192 Score = 2426 bits (6287), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1189/1192 (99%), Positives = 1192/1192 (100%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAV+PLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVDPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDI+LSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIVLSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|254551156|ref|ZP_05141603.1| 5-methyltetrahydrofolate-homocystein methyltransferase metH [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=1192 Score = 2426 bits (6287), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1190/1192 (99%), Positives = 1191/1192 (99%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVL SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLRSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|294993532|ref|ZP_06799223.1| 5-methyltetrahydrofolate-homocystein methyltransferase metH [Mycobacterium tuberculosis 210] gi|339298665|gb|AEJ50775.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis CCDC5180] Length=1192 Score = 2425 bits (6284), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1190/1192 (99%), Positives = 1191/1192 (99%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAE WHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEDWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|289754232|ref|ZP_06513610.1| Methionine synthase [Mycobacterium tuberculosis EAS054] gi|289694819|gb|EFD62248.1| Methionine synthase [Mycobacterium tuberculosis EAS054] Length=1167 Score = 2291 bits (5938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1123/1124 (99%), Positives = 1124/1124 (100%), Gaps = 0/1124 (0%) Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMG 128 +AGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMG Sbjct 44 KAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMG 103 Query 129 PGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRA 188 PGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRA Sbjct 104 PGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRA 163 Query 189 GRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRH 248 GRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRH Sbjct 164 GRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRH 223 Query 249 ARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREV 308 ARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREV Sbjct 224 ARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREV 283 Query 309 AAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQ 368 AAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQ Sbjct 284 AAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQ 343 Query 369 KCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAG 428 KCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAG Sbjct 344 KCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAG 403 Query 429 LEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIA 488 LEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIA Sbjct 404 LEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIA 463 Query 489 ERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLG 548 ERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLG Sbjct 464 ERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLG 523 Query 549 LSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDR 608 LSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDR Sbjct 524 LSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDR 583 Query 609 RREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAM 668 RREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAM Sbjct 584 RREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAM 643 Query 669 TQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG 728 TQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG Sbjct 644 TQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG 703 Query 729 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSG 788 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSG Sbjct 704 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSG 763 Query 789 LLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEG 848 LLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEG Sbjct 764 LLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEG 823 Query 849 LKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERS 908 LKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERS Sbjct 824 LKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERS 883 Query 909 DVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVET 968 DVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVET Sbjct 884 DVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVET 943 Query 969 EGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQ 1028 EGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQ Sbjct 944 EGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQ 1003 Query 1029 RGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIG 1088 RGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIG Sbjct 1004 RGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIG 1063 Query 1089 VQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLED 1148 VQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLED Sbjct 1064 VQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLED 1123 Query 1149 RAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 RAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1124 RAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1167 >gi|240171403|ref|ZP_04750062.1| 5-methyltetrahydrofolate-homocystein methyltransferase metH [Mycobacterium kansasii ATCC 12478] Length=1192 Score = 2289 bits (5933), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1114/1192 (94%), Positives = 1160/1192 (98%), Gaps = 0/1192 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAA+K YDTDLLDVL+QRV+VGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAANKPRYDTDLLDVLAQRVVVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIAD+IRDLS+KGT IARRVADEL +P+RK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADKIRDLSEKGTTIARRVADELSTPERK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHT+YAVIRDAYTEAALGMLDGGAD+ILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTDYAVIRDAYTEAALGMLDGGADSILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAM +AGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMKQAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLR+LSRHARIPVSVMPNAGLPVLGAKGAEYPL PDELAEAL+GFIAEFGLSLVGGCCGT Sbjct 241 HLRYLSRHARIPVSVMPNAGLPVLGAKGAEYPLRPDELAEALSGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAV RPERQVS+EPSVSSLY+A+PFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVVGAPRPERQVSFEPSVSSLYSAVPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ET VLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTM LVAEHGAAVVALTIDEEGQART Sbjct 421 ETPVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMELVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 A+KKVEIAERLINDIT NWGVDESSILIDTLTFTIATGQEESR+DGIETIEAIRELKKRH Sbjct 481 AEKKVEIAERLINDITTNWGVDESSILIDTLTFTIATGQEESRKDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQR V Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRTV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRR+ YDPLQELMRLFEGVSAASSKE R AELA LPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRRDGYDPLQELMRLFEGVSAASSKESRAAELAKLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 +ADLDEAMTQKPPL+IINE+LLAGMKTVGELFGSGQMQLPFVLQSAEVMK AVAYLEPHM Sbjct 661 EADLDEAMTQKPPLEIINENLLAGMKTVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 E+SDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 EKSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMN+RGVAEKFPVLLGGAALTRSYVENDLA+IY+GEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNSRGVAEKFPVLLGGAALTRSYVENDLADIYEGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMS+KRGEAPD +SPEAI+AR+KEAERKARH+RSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSSKRGEAPDVDSPEAIQARKKEAERKARHERSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVE+PERSDVAADIEVPAPPFWGSRIVKGLAVADYTG+LDERALFLGQWGLRGQRG +GP Sbjct 901 PVEIPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGMLDERALFLGQWGLRGQRGADGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEG+++VVLTEP DA RY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGDEVVVLTEPAADAEERY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RF FPRQQRGRFLCIADF+RSRE A ERG+VDVLPFQLVTMGQPIADFANELFA+++YRD Sbjct 1021 RFRFPRQQRGRFLCIADFVRSREHARERGQVDVLPFQLVTMGQPIADFANELFAADSYRD 1080 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREEL++S DR MAAEDP+A EDYFKLGYRGARFAFGY Sbjct 1081 YLEVHGIGVQLTEALAEYWHRRIREELRYSADRTMAAEDPDAVEDYFKLGYRGARFAFGY 1140 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDLEDRAKMM LLEP+RIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1141 GACPDLEDRAKMMQLLEPDRIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|289570237|ref|ZP_06450464.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis T17] gi|289543991|gb|EFD47639.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis T17] Length=1104 Score = 2199 bits (5697), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1081/1084 (99%), Positives = 1082/1084 (99%), Gaps = 0/1084 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVG CCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGDCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH Sbjct 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE Sbjct 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP Sbjct 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY Sbjct 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD Sbjct 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 Query 1081 YLEV 1084 YLE Sbjct 1081 YLEC 1084 >gi|15827677|ref|NP_301940.1| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mycobacterium leprae TN] gi|221230154|ref|YP_002503570.1| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mycobacterium leprae Br4923] gi|13638433|sp|Q49775.3|METH_MYCLE RecName: Full=Methionine synthase; AltName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase; AltName: Full=Methionine synthase, vitamin-B12 dependent; Short=MS gi|13093228|emb|CAC31688.1| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mycobacterium leprae] gi|219933261|emb|CAR71402.1| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mycobacterium leprae Br4923] Length=1206 Score = 2172 bits (5627), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1064/1204 (89%), Positives = 1117/1204 (93%), Gaps = 12/1204 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 VTAA++H YDTDLL+ L+QRVMVGDGAMGTQLQ A+LTLDDFRGLEGCNEILNETRPDVL Sbjct 3 VTAANQHQYDTDLLETLAQRVMVGDGAMGTQLQDAELTLDDFRGLEGCNEILNETRPDVL 62 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHR YFEAGAD VETNTFGCNLSNLGDYDIAD+IRDLSQ+GT IARRVADEL +PD K Sbjct 63 ETIHRRYFEAGADLVETNTFGCNLSNLGDYDIADKIRDLSQRGTVIARRVADELTTPDHK 122 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEY V+RDAYTE+ALGMLDGGADA+LVETCQDLLQLKAAVLG Sbjct 123 RYVLGSMGPGTKLPTLGHTEYRVVRDAYTESALGMLDGGADAVLVETCQDLLQLKAAVLG 182 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMT+AGRHIPVF HVTVETTGTMLLGSEIGAAL AVEPLGVDMIGLNCATGPAEMSE Sbjct 183 SRRAMTQAGRHIPVFVHVTVETTGTMLLGSEIGAALAAVEPLGVDMIGLNCATGPAEMSE 242 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLS+HARIPVSVMPNAGLPVLGAKGAEYPL PDELAEALAGFIAEFGLSLVGGCCGT Sbjct 243 HLRHLSKHARIPVSVMPNAGLPVLGAKGAEYPLQPDELAEALAGFIAEFGLSLVGGCCGT 302 Query 301 TPAHIREVAAAVA-----NIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGS 355 TP HIREVAAAVA + R ER V+YEPSVSSLYTAIPFAQ SVL+IGERTNANGS Sbjct 303 TPDHIREVAAAVARCNDGTVPRGERHVTYEPSVSSLYTAIPFAQKPSVLMIGERTNANGS 362 Query 356 KGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPI 415 K FREAMIAEDYQKCLDIAKDQTR GAHLLDLCVDYVGR+GVADMKALA RLAT STLPI Sbjct 363 KVFREAMIAEDYQKCLDIAKDQTRGGAHLLDLCVDYVGRNGVADMKALAGRLATVSTLPI 422 Query 416 MLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEE 475 MLDSTE VLQAGLEHLGGRC INSVNYEDGDGPESRF KTM LVAEHGAAVVALTIDE+ Sbjct 423 MLDSTEIPVLQAGLEHLGGRCVINSVNYEDGDGPESRFVKTMELVAEHGAAVVALTIDEQ 482 Query 476 GQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRE 535 GQART +KKVE+AERLINDIT NWGVD+S+ILID LTFTIATGQEESR+DGIETI+AIRE Sbjct 483 GQARTVEKKVEVAERLINDITSNWGVDKSAILIDCLTFTIATGQEESRKDGIETIDAIRE 542 Query 536 LKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPE 595 LKKRHP VQTTLGLSNISFGLNP+ARQVLNSVFLHECQEAGLDSAIVHASKILP+NRIPE Sbjct 543 LKKRHPAVQTTLGLSNISFGLNPSARQVLNSVFLHECQEAGLDSAIVHASKILPINRIPE 602 Query 596 EQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDG 655 EQR ALDLVYDRRRE YDPLQ+LM LF+GVS+ SSKE R AELA LPLF+RLAQRIVDG Sbjct 603 EQRQAALDLVYDRRREGYDPLQKLMWLFKGVSSPSSKETREAELAKLPLFDRLAQRIVDG 662 Query 656 ERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAY 715 ERNGLD DLDEAMTQKPPL IINE+LL GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAY Sbjct 663 ERNGLDVDLDEAMTQKPPLAIINENLLDGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAY 722 Query 716 LEPHMERSDDDSG----KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIAT 771 LEPHME+SD D G KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVN+GIKQPI Sbjct 723 LEPHMEKSDCDFGKGLAKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNLGIKQPITN 782 Query 772 ILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDL 831 ILEVAEDKSADVVGMSGLLVKSTV+MKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDL Sbjct 783 ILEVAEDKSADVVGMSGLLVKSTVIMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDL 842 Query 832 AEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKA---REKEAERKARHQRS 888 AE+Y+GEVHYARDAFEGLKLMDTIMSAKRGEA SPE++ A R KE ERKARH+RS Sbjct 843 AEVYEGEVHYARDAFEGLKLMDTIMSAKRGEALAPGSPESLAAEADRNKETERKARHERS 902 Query 889 KRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQ 948 KRIA QRKAAEEPVEVPERSDV +D+EVPAPPFWGSRI+KGLAVADYTG LDERALFLGQ Sbjct 903 KRIAVQRKAAEEPVEVPERSDVPSDVEVPAPPFWGSRIIKGLAVADYTGFLDERALFLGQ 962 Query 949 WGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVV 1008 WGLRG RGG GPSYEDLV+TEGRPRLRYWLDRLST G+LA+AAVVYGYFPAVSE NDIVV Sbjct 963 WGLRGVRGGAGPSYEDLVQTEGRPRLRYWLDRLSTYGVLAYAAVVYGYFPAVSEDNDIVV 1022 Query 1009 LTEPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADF 1068 L EP+PDA RYRF FPRQQRGRFLCIADFIRSR+LA ER EVDVLPFQLVTMGQPIADF Sbjct 1023 LAEPRPDAEQRYRFTFPRQQRGRFLCIADFIRSRDLATERSEVDVLPFQLVTMGQPIADF 1082 Query 1069 ANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFK 1128 ELF SN+YRDYLEVHGIGVQLTEALAEYWHRRIREELKFSG+R M+A+DPEA EDYFK Sbjct 1083 VGELFVSNSYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGNRTMSADDPEAVEDYFK 1142 Query 1129 LGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAK 1188 LGYRGARFAFGYGACPDLEDR KMM LL+PERIGVT+SEELQLHPEQSTDAFVLHHP AK Sbjct 1143 LGYRGARFAFGYGACPDLEDRIKMMELLQPERIGVTISEELQLHPEQSTDAFVLHHPAAK 1202 Query 1189 YFNV 1192 YFNV Sbjct 1203 YFNV 1206 >gi|4200262|emb|CAA22918.1| putative 5-methyltetrahydrofolate-homocysteine methyltransferase [Mycobacterium leprae] Length=1183 Score = 2138 bits (5541), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1049/1183 (89%), Positives = 1098/1183 (93%), Gaps = 12/1183 (1%) Query 22 MVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGADAVETNTFG 81 MVGDGAMGTQLQ A+LTLDDFRGLEGCNEILNETRPDVLETIHR YFEAGAD VETNTFG Sbjct 1 MVGDGAMGTQLQDAELTLDDFRGLEGCNEILNETRPDVLETIHRRYFEAGADLVETNTFG 60 Query 82 CNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTKLPTLGHTEY 141 CNLSNLGDYDIAD+IRDLSQ+GT IARRVADEL +PD KRYVLGSMGPGTKLPTLGHTEY Sbjct 61 CNLSNLGDYDIADKIRDLSQRGTVIARRVADELTTPDHKRYVLGSMGPGTKLPTLGHTEY 120 Query 142 AVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHIPVFAHVTVE 201 V+RDAYTE+ALGMLDGGADA+LVETCQDLLQLKAAVLGSRRAMT+AGRHIPVF HVTVE Sbjct 121 RVVRDAYTESALGMLDGGADAVLVETCQDLLQLKAAVLGSRRAMTQAGRHIPVFVHVTVE 180 Query 202 TTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIPVSVMPNAGL 261 TTGTMLLGSEIGAAL AVEPLGVDMIGLNCATGPAEMSEHLRHLS+HARIPVSVMPNAGL Sbjct 181 TTGTMLLGSEIGAALAAVEPLGVDMIGLNCATGPAEMSEHLRHLSKHARIPVSVMPNAGL 240 Query 262 PVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAVA-----NIK 316 PVLGAKGAEYPL PDELAEALAGFIAEFGLSLVGGCCGTTP HIREVAAAVA + Sbjct 241 PVLGAKGAEYPLQPDELAEALAGFIAEFGLSLVGGCCGTTPDHIREVAAAVARCNDGTVP 300 Query 317 RPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKD 376 R ER V+YEPSVSSLYTAIPFAQ SVL+IGERTNANGSK FREAMIAEDYQKCLDIAKD Sbjct 301 RGERHVTYEPSVSSLYTAIPFAQKPSVLMIGERTNANGSKVFREAMIAEDYQKCLDIAKD 360 Query 377 QTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRC 436 QTR GAHLLDLCVDYVGR+GVADMKALA RLAT STLPIMLDSTE VLQAGLEHLGGRC Sbjct 361 QTRGGAHLLDLCVDYVGRNGVADMKALAGRLATVSTLPIMLDSTEIPVLQAGLEHLGGRC 420 Query 437 AINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLINDIT 496 INSVNYEDGDGPESRF KTM LVAEHGAAVVALTIDE+GQART +KKVE+AERLINDIT Sbjct 421 VINSVNYEDGDGPESRFVKTMELVAEHGAAVVALTIDEQGQARTVEKKVEVAERLINDIT 480 Query 497 GNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGL 556 NWGVD+S+ILID LTFTIATGQEESR+DGIETI+AIRELKKRHP VQTTLGLSNISFGL Sbjct 481 SNWGVDKSAILIDCLTFTIATGQEESRKDGIETIDAIRELKKRHPAVQTTLGLSNISFGL 540 Query 557 NPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPL 616 NP+ARQVLNSVFLHECQEAGLDSAIVHASKILP+NRIPEEQR ALDLVYDRRRE YDPL Sbjct 541 NPSARQVLNSVFLHECQEAGLDSAIVHASKILPINRIPEEQRQAALDLVYDRRREGYDPL 600 Query 617 QELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQI 676 Q+LM LF+GVS+ SSKE R AELA LPLF+RLAQRIVDGERNGLD DLDEAMTQKPPL I Sbjct 601 QKLMWLFKGVSSPSSKETREAELAKLPLFDRLAQRIVDGERNGLDVDLDEAMTQKPPLAI 660 Query 677 INEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG----KGRI 732 INE+LL GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME+SD D G KGRI Sbjct 661 INENLLDGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMEKSDCDFGKGLAKGRI 720 Query 733 VLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVK 792 VLATVKGDVHDIGKNLVDIILSNNGYEVVN+GIKQPI ILEVAEDKSADVVGMSGLLVK Sbjct 721 VLATVKGDVHDIGKNLVDIILSNNGYEVVNLGIKQPITNILEVAEDKSADVVGMSGLLVK 780 Query 793 STVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLM 852 STV+MKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAE+Y+GEVHYARDAFEGLKLM Sbjct 781 STVIMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEVYEGEVHYARDAFEGLKLM 840 Query 853 DTIMSAKRGEAPDENSPEAIKA---REKEAERKARHQRSKRIAAQRKAAEEPVEVPERSD 909 DTIMSAKRGEA SPE++ A R KE ERKARH+RSKRIA QRKAAEEPVEVPERSD Sbjct 841 DTIMSAKRGEALAPGSPESLAAEADRNKETERKARHERSKRIAVQRKAAEEPVEVPERSD 900 Query 910 VAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETE 969 V +D+EVPAPPFWGSRI+KGLAVADYTG LDERALFLGQWGLRG RGG GPSYEDLV+TE Sbjct 901 VPSDVEVPAPPFWGSRIIKGLAVADYTGFLDERALFLGQWGLRGVRGGAGPSYEDLVQTE 960 Query 970 GRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQR 1029 GRPRLRYWLDRLST G+LA+AAVVYGYFPAVSE NDIVVL EP+PDA RYRF FPRQQR Sbjct 961 GRPRLRYWLDRLSTYGVLAYAAVVYGYFPAVSEDNDIVVLAEPRPDAEQRYRFTFPRQQR 1020 Query 1030 GRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGV 1089 GRFLCIADFIRSR+LA ER EVDVLPFQLVTMGQPIADF ELF SN+YRDYLEVHGIGV Sbjct 1021 GRFLCIADFIRSRDLATERSEVDVLPFQLVTMGQPIADFVGELFVSNSYRDYLEVHGIGV 1080 Query 1090 QLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDR 1149 QLTEALAEYWHRRIREELKFSG+R M+A+DPEA EDYFKLGYRGARFAFGYGACPDLEDR Sbjct 1081 QLTEALAEYWHRRIREELKFSGNRTMSADDPEAVEDYFKLGYRGARFAFGYGACPDLEDR 1140 Query 1150 AKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 KMM LL+PERIGVT+SEELQLHPEQSTDAFVLHHP AKYFNV Sbjct 1141 IKMMELLQPERIGVTISEELQLHPEQSTDAFVLHHPAAKYFNV 1183 >gi|54025162|ref|YP_119404.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Nocardia farcinica IFM 10152] gi|54016670|dbj|BAD58040.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Nocardia farcinica IFM 10152] Length=1198 Score = 1996 bits (5171), Expect = 0.0, Method: Compositional matrix adjust. Identities = 972/1191 (82%), Positives = 1075/1191 (91%), Gaps = 10/1191 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 +DT LLD L +RV++GDGAMGT LQA DLTLDDFRGLEGCNEILNETRPDVL IHR YF Sbjct 9 FDTTLLDTLRRRVVIGDGAMGTMLQAVDLTLDDFRGLEGCNEILNETRPDVLRAIHRAYF 68 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELG-SPD-RKRYVLGS 126 EAGADAVETNTFGCNLSNLGDYDIADRIRDLS++GT +AR VADE+G PD RYVLGS Sbjct 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSERGTRLAREVADEMGPGPDGTPRYVLGS 128 Query 127 MGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMT 186 MGPGTKLPTLGH Y +RDAY E+ALGMLDGGADAIL+ETCQDLLQ+KAAV GSRRAM Sbjct 129 MGPGTKLPTLGHAPYTALRDAYVESALGMLDGGADAILIETCQDLLQVKAAVTGSRRAME 188 Query 187 RAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLS 246 AGR IP+ HVTVETTGTML+GSEIGAALTA+EPLG+D+IGLNCATGP EMSEHLRHLS Sbjct 189 LAGRRIPIITHVTVETTGTMLVGSEIGAALTALEPLGIDVIGLNCATGPDEMSEHLRHLS 248 Query 247 RHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIR 306 +HA +PVSVMPNAGLPVLG GAEYPL P+ELA AL GF++EFGL+LVGGCCGTTP HIR Sbjct 249 KHATVPVSVMPNAGLPVLGPNGAEYPLTPEELAVALRGFVSEFGLALVGGCCGTTPEHIR 308 Query 307 EVAAAV----ANIKRPERQVSYEP--SVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 +VA AV A + PE++ S EP +VSS+YT++PFAQDASVL+IGERTNANGSK FRE Sbjct 309 QVAEAVREVEATLPPPEQRRSPEPEPAVSSMYTSVPFAQDASVLMIGERTNANGSKAFRE 368 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AM+AED+QKCLDIAKDQTRDGAH+LDLCVDYVGRDG DM LASRLATSSTLPIMLDST Sbjct 369 AMLAEDWQKCLDIAKDQTRDGAHMLDLCVDYVGRDGTRDMTELASRLATSSTLPIMLDST 428 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 E AVLQAGLEHLGGRCA+NSVNYEDG GP+SRF + M LVAEHGAAVVALTIDEEGQART Sbjct 429 EPAVLQAGLEHLGGRCAVNSVNYEDGAGPQSRFQQIMRLVAEHGAAVVALTIDEEGQART 488 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 A+KKVEIAERLI DITGNWG+DES I+IDTLTFT+ TGQEESRRDG+ETIEAIRELK+RH Sbjct 489 AEKKVEIAERLIADITGNWGLDESDIIIDTLTFTLGTGQEESRRDGLETIEAIRELKRRH 548 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 P VQTTLGLSNISFGLNPAARQVLNSVF+HEC +AGLDSAIVHASKILPM+RIPEEQR Sbjct 549 PRVQTTLGLSNISFGLNPAARQVLNSVFMHECVQAGLDSAIVHASKILPMSRIPEEQRTT 608 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDL+YDRR DYDPLQ+LM +FEGVS++SSK R ELA LPLFERL +RIVDGE+ G+ Sbjct 609 ALDLIYDRRTPDYDPLQQLMAMFEGVSSSSSKASRAEELAALPLFERLERRIVDGEKAGM 668 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 +ADLDEAM + PPL+IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 669 EADLDEAMREVPPLRIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 728 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 E S DDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVN+GIKQPI +IL+ A DK Sbjct 729 E-STDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNLGIKQPITSILDAAVDKK 787 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 ADV+GMSGLLVKSTVVMKENLEE+N+RGVA++FPVLLGGAALTR+YVENDL ++Y+G+VH Sbjct 788 ADVIGMSGLLVKSTVVMKENLEELNSRGVADQFPVLLGGAALTRAYVENDLTDVYEGDVH 847 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGL+LMD IM+ KRGEAPD NSPEA+ REK AERKARH+RSKRIA +RKAAE Sbjct 848 YARDAFEGLRLMDEIMARKRGEAPDPNSPEAVAEREKAAERKARHERSKRIAEKRKAAET 907 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVP RSDVAAD+ VP PPFWG+R+VKGLAV +Y+GLLDERALFLGQWGLRGQRGG+GP Sbjct 908 PVEVPARSDVAADLPVPVPPFWGTRVVKGLAVHEYSGLLDERALFLGQWGLRGQRGGDGP 967 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYE+LVE+EGRPRLR WLDRL+T+G+L HAAVVYGYFPAVSEG+D++VLTEP+PDAP RY Sbjct 968 SYEELVESEGRPRLRAWLDRLATEGVLQHAAVVYGYFPAVSEGDDVIVLTEPEPDAPQRY 1027 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 RF FPRQQR RFLCIADFIRSRELA E G+VDVLPFQLVTMGQPIADFANELFA++ YRD Sbjct 1028 RFTFPRQQRDRFLCIADFIRSRELARETGQVDVLPFQLVTMGQPIADFANELFAADNYRD 1087 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWHRRIREEL G A+A DPE ++YFKLGYRGAR++FGY Sbjct 1088 YLEVHGIGVQLTEALAEYWHRRIREELVLEG-HAVAESDPEDVQEYFKLGYRGARYSFGY 1146 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 GACPDLEDRAK++ LLE +RIGV LSEELQLHPEQSTDAFVL HPEAKYFN Sbjct 1147 GACPDLEDRAKLVDLLEADRIGVVLSEELQLHPEQSTDAFVLLHPEAKYFN 1197 >gi|343927957|ref|ZP_08767423.1| methionine synthase [Gordonia alkanivorans NBRC 16433] gi|343762180|dbj|GAA14349.1| methionine synthase [Gordonia alkanivorans NBRC 16433] Length=1196 Score = 1934 bits (5011), Expect = 0.0, Method: Compositional matrix adjust. Identities = 946/1186 (80%), Positives = 1044/1186 (89%), Gaps = 4/1186 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 +DT L +S+RV++GDGAMGT LQAADLTLDDF LEGCNEILN+TRPDVLE IHR YF Sbjct 13 FDTTFLSSMSRRVLIGDGAMGTMLQAADLTLDDFHNLEGCNEILNDTRPDVLEGIHRAYF 72 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELG-SPD-RKRYVLGS 126 EAGADAVETNTFGCNLSNLGDYDIADRIR+L+ KGTAIAR VADE+G S D RYVLGS Sbjct 73 EAGADAVETNTFGCNLSNLGDYDIADRIRELAYKGTAIARGVADEMGPSADGTGRYVLGS 132 Query 127 MGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMT 186 MGPGTKLP+LGHT +A IRDAY E +GML+GGADA+L+ET QDLLQ+KAAV+ ++RAM Sbjct 133 MGPGTKLPSLGHTTFATIRDAYQECVIGMLEGGADAVLIETSQDLLQVKAAVIAAQRAMD 192 Query 187 RAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLS 246 R GR IP+ +HVTVETTGTMLLGSEIGAAL A+EPLGVD+IGLNCATGPAEMSEHLR+LS Sbjct 193 RVGRRIPIISHVTVETTGTMLLGSEIGAALAAIEPLGVDLIGLNCATGPAEMSEHLRYLS 252 Query 247 RHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIR 306 +HARIPVSVMPNAGLPVLGA GAEYPL P+ELAE++A F+ EFGLS VGGCCGTTP HIR Sbjct 253 KHARIPVSVMPNAGLPVLGANGAEYPLTPEELAESMAQFVGEFGLSFVGGCCGTTPEHIR 312 Query 307 EVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAED 366 +VA AVA + R +E SSLYTA+PF QDAS LVIGERTN NGSK FREAMIAED Sbjct 313 QVAEAVAQVTPATRTPEHESETSSLYTAVPFDQDASFLVIGERTNTNGSKAFREAMIAED 372 Query 367 YQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQ 426 YQ+CLDIAKDQTRDGAH+LDL VDYVGRDG ADM ALASR ATSSTLPIMLDSTE V++ Sbjct 373 YQRCLDIAKDQTRDGAHMLDLNVDYVGRDGAADMTALASRFATSSTLPIMLDSTEPEVIR 432 Query 427 AGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVE 486 AGLE LGGRCA+NSVNYEDGDGP+SRF K M LV EHGAAVVALTIDEEGQARTA KV Sbjct 433 AGLEALGGRCAVNSVNYEDGDGPDSRFNKIMQLVVEHGAAVVALTIDEEGQARTADWKVS 492 Query 487 IAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTT 546 +AERLI DITGNWG+ E I+ID LTF I+TGQEE RRDGIETIEAIR L + HPDV T Sbjct 493 VAERLIADITGNWGLAEEDIIIDALTFPISTGQEEVRRDGIETIEAIRRLHETHPDVHFT 552 Query 547 LGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVY 606 LG+SNISFGLNPAARQVLNSVFLHEC +AGLD+AIVHASKILPM RIPEE R VALDLVY Sbjct 553 LGISNISFGLNPAARQVLNSVFLHECVQAGLDTAIVHASKILPMARIPEEHRQVALDLVY 612 Query 607 DRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDE 666 DRRRE YDPLQ+LM LFEGVSAAS++E R ELA LPLFERL +RIVDGERNGL DLDE Sbjct 613 DRRREGYDPLQKLMELFEGVSAASARESRAQELAKLPLFERLERRIVDGERNGLTDDLDE 672 Query 667 AMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDD 726 AMTQ PPL IIN+ LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVA+LEPHME + +D Sbjct 673 AMTQVPPLSIINDTLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAHLEPHMEATGED 732 Query 727 SGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGM 786 GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATIL+VA DK DV+GM Sbjct 733 -GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILDVAADKRVDVIGM 791 Query 787 SGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAF 846 SGLLVKSTVVMKENLEE+NTRG+A+++PVLLGGAALTRSYVENDL+++Y+G+VHYARDAF Sbjct 792 SGLLVKSTVVMKENLEEINTRGLADEYPVLLGGAALTRSYVENDLSDVYEGDVHYARDAF 851 Query 847 EGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPE 906 EGL+LMD IM+ KRG PD +S EA K AERKARH+RSKRIAA+RKAAEEPVEVP Sbjct 852 EGLRLMDDIMARKRGGGPDPDSDEAKAEAAKTAERKARHERSKRIAAKRKAAEEPVEVPS 911 Query 907 RSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLV 966 RSDVAAD E+P PPFWGSRIVKG+ +ADY LLDERALFLGQWGLRG RGG+GPSYE+LV Sbjct 912 RSDVAADNEIPTPPFWGSRIVKGVPIADYLQLLDERALFLGQWGLRGARGGDGPSYEELV 971 Query 967 ETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPR 1026 E+EGRPRLRYW+DRL+T+ IL HAAVVYGY+PAVSEG+ + VLTEP PDAPVR+ F FPR Sbjct 972 ESEGRPRLRYWIDRLATENILQHAAVVYGYYPAVSEGDTVHVLTEPDPDAPVRFSFSFPR 1031 Query 1027 QQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHG 1086 QQR RFLCIADFI+SRE A G VDV+PFQLVTMGQPIADFAN+LFA +AYRDYLEVHG Sbjct 1032 QQRSRFLCIADFIQSREAAKAAGRVDVMPFQLVTMGQPIADFANKLFAEDAYRDYLEVHG 1091 Query 1087 IGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDL 1146 IGVQLTEALAEYWH+R+R ELKF GDR+M +EDPE + +F L YRGARF+FGYGACPDL Sbjct 1092 IGVQLTEALAEYWHQRVRSELKF-GDRSMDSEDPEHAQGFFDLEYRGARFSFGYGACPDL 1150 Query 1147 EDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 EDRAKM+ LLEPERIGV LSEELQLHPEQSTDAFVLHHPEAKYFN Sbjct 1151 EDRAKMIELLEPERIGVQLSEELQLHPEQSTDAFVLHHPEAKYFNT 1196 >gi|111017878|ref|YP_700850.1| methionine synthase [Rhodococcus jostii RHA1] gi|110817408|gb|ABG92692.1| methionine synthase [Rhodococcus jostii RHA1] Length=1189 Score = 1930 bits (5001), Expect = 0.0, Method: Compositional matrix adjust. Identities = 944/1187 (80%), Positives = 1052/1187 (89%), Gaps = 5/1187 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 + + LLD L+QRV++GDGAMGT LQAADLTLDDF GLEGCNEILN+TRPDVL+ IHR YF Sbjct 5 FHSALLDALNQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNDTRPDVLKDIHRAYF 64 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK---RYVLG 125 EAGADAVETNTFGCNL NL DYDI+DRIR+L++KGT +AR VADE+G P R R+VLG Sbjct 65 EAGADAVETNTFGCNLPNLADYDISDRIRELAEKGTRLARDVADEMG-PGRDGMGRFVLG 123 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 SMGPGTKLPTLGH +A++RDAY EAA+GM+DGGADAILVETCQDLLQ+KAA+LGS+RAM Sbjct 124 SMGPGTKLPTLGHAPFAILRDAYAEAAMGMIDGGADAILVETCQDLLQVKAAILGSQRAM 183 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGPAEMSEHLRHL Sbjct 184 ETLGSRLPIITHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPAEMSEHLRHL 243 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 S+++ +PVSVMPNAGLP LG GAEYPL +ELAEAL+GF+ EFGL LVGGCCGTTP HI Sbjct 244 SKYSSLPVSVMPNAGLPQLGPNGAEYPLTAEELAEALSGFVTEFGLGLVGGCCGTTPEHI 303 Query 306 REVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAE 365 R+VA AV +++ ER +E SSLYTA+PF QDAS+L+IGERTN NGSK FREAMIAE Sbjct 304 RQVAEAVRLVEKAERNPVHESGTSSLYTAVPFQQDASILMIGERTNTNGSKAFREAMIAE 363 Query 366 DYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVL 425 DYQKCLDIAKDQTRDGAH+LDL VDYVGRDG DM ALASR ATSSTLPIMLDSTE AVL Sbjct 364 DYQKCLDIAKDQTRDGAHMLDLNVDYVGRDGAVDMAALASRFATSSTLPIMLDSTEPAVL 423 Query 426 QAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKV 485 QAGLEHLGGRCA+NSVNYEDGDGP+SRF K M LV EHGAAVVALTIDEEGQARTA+ KV Sbjct 424 QAGLEHLGGRCAVNSVNYEDGDGPDSRFQKIMRLVTEHGAAVVALTIDEEGQARTAEHKV 483 Query 486 EIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQT 545 IAERL++DIT NWG+DES I+ID LTF I+TGQEE RRDGIETIEAIRELKKRHP V Sbjct 484 RIAERLLDDITANWGLDESDIIIDALTFPISTGQEEVRRDGIETIEAIRELKKRHPRVHF 543 Query 546 TLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLV 605 TLG+SNISFGLNPAARQVLNSVFLHEC EAGLD+AIVHASKILPM RIP+EQR ALDLV Sbjct 544 TLGVSNISFGLNPAARQVLNSVFLHECTEAGLDTAIVHASKILPMARIPDEQRETALDLV 603 Query 606 YDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLD 665 YDRRRE YDPLQ+LM LFEGVSAAS++E R ELA LPLFERL +RIVDGERNGLD DL Sbjct 604 YDRRREGYDPLQKLMELFEGVSAASARESRAQELAALPLFERLERRIVDGERNGLDDDLT 663 Query 666 EAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDD 725 AM +KPPL IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME +D+ Sbjct 664 AAMEEKPPLAIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMEATDE 723 Query 726 DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVG 785 D GKGRIV+ATVKGDVHDIGKNLVDIILSNNGY+VVN+GIKQPIATIL+ A ++ ADV+G Sbjct 724 D-GKGRIVIATVKGDVHDIGKNLVDIILSNNGYDVVNLGIKQPIATILDAAIEQKADVIG 782 Query 786 MSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDA 845 MSGLLVKSTVVMK+NL+E+N +GVAEKFPVLLGGAALTRSYVENDLAE+Y+G+V YARDA Sbjct 783 MSGLLVKSTVVMKDNLQELNAKGVAEKFPVLLGGAALTRSYVENDLAEVYEGDVSYARDA 842 Query 846 FEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVP 905 FEGL MD IM+ KRG PD +SPEAI AREK AERKARH+RSKRIA +RKAAE P+EVP Sbjct 843 FEGLHRMDEIMAVKRGGGPDPDSPEAIAAREKAAERKARHERSKRIAEKRKAAETPIEVP 902 Query 906 ERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDL 965 ERSDVA DI VP PPFWG+RIVKG++++DY+GLLDERALFLGQWGLRGQR G+GP+YE+L Sbjct 903 ERSDVATDIVVPTPPFWGNRIVKGVSLSDYSGLLDERALFLGQWGLRGQRSGDGPTYEEL 962 Query 966 VETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFP 1025 VETEGRPRLRYWLDRLST+GILAHAAVVYGYFPAVSEG+D+VVLT+P PDA R+RF FP Sbjct 963 VETEGRPRLRYWLDRLSTEGILAHAAVVYGYFPAVSEGDDVVVLTDPTPDAEERFRFTFP 1022 Query 1026 RQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVH 1085 RQ R RFLC+ADF+RSR A E G+VDV P QLVTMGQPIADFANELFA+NAYRDYLEVH Sbjct 1023 RQHRDRFLCVADFVRSRTEAKETGQVDVFPMQLVTMGQPIADFANELFAANAYRDYLEVH 1082 Query 1086 GIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPD 1145 GIGVQLTE+LAEYWH+R+REEL G +A +DP +F L YRGAR++FGYGACP+ Sbjct 1083 GIGVQLTESLAEYWHQRVREELVLPGGHNVAEQDPSEVSGFFDLAYRGARYSFGYGACPN 1142 Query 1146 LEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LEDRAKM+ALLEPERIGV LSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1143 LEDRAKMVALLEPERIGVKLSEELQLHPEQSTDAFVLHHPEAKYFNV 1189 >gi|226360011|ref|YP_002777789.1| methionine synthase [Rhodococcus opacus B4] gi|226238496|dbj|BAH48844.1| methionine synthase [Rhodococcus opacus B4] Length=1189 Score = 1928 bits (4995), Expect = 0.0, Method: Compositional matrix adjust. Identities = 944/1187 (80%), Positives = 1053/1187 (89%), Gaps = 5/1187 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 + + LLD L+QRV++GDGAMGT LQAADLTLDDF GLEGCNEILN+TRPDVL+ IHR YF Sbjct 5 FHSALLDALNQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNDTRPDVLKEIHRAYF 64 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK---RYVLG 125 EAGADAVETNTFGCNL NL DYDI+DRIR+L++KGT +AR VADE+G P R R+VLG Sbjct 65 EAGADAVETNTFGCNLPNLADYDISDRIRELAEKGTRLAREVADEMG-PGRDGMGRFVLG 123 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 SMGPGTKLPTLGH +A++RDAY EAA+GM+DGGADAILVETCQDLLQ+KAA+LGS+RAM Sbjct 124 SMGPGTKLPTLGHAPFAILRDAYAEAAMGMIDGGADAILVETCQDLLQVKAAILGSQRAM 183 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGPAEMSEHLRHL Sbjct 184 ETLGSRLPIITHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPAEMSEHLRHL 243 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 S+++ +PVSVMPNAGLP LG GAEYPL +ELAEAL+GF+ EFGL LVGGCCGTTP HI Sbjct 244 SKYSSLPVSVMPNAGLPQLGPNGAEYPLTAEELAEALSGFVTEFGLGLVGGCCGTTPEHI 303 Query 306 REVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAE 365 R+VA AV +++ R +E SSLYTA+PF QDAS+L+IGERTN+NGSK FREAMIAE Sbjct 304 RQVADAVRLVEKAARNPVHESGTSSLYTAVPFEQDASILMIGERTNSNGSKAFREAMIAE 363 Query 366 DYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVL 425 DYQKCLDIAKDQTRDGAH+LDL VDYVGRDG ADM ALASR ATSSTLPIMLDSTE AVL Sbjct 364 DYQKCLDIAKDQTRDGAHMLDLNVDYVGRDGAADMAALASRFATSSTLPIMLDSTEPAVL 423 Query 426 QAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKV 485 QAGLEHLGGRCA+NSVNYEDGDGP+SRF K M LV EHGAAVVALTIDEEGQARTA+ KV Sbjct 424 QAGLEHLGGRCAVNSVNYEDGDGPDSRFQKIMRLVKEHGAAVVALTIDEEGQARTAEHKV 483 Query 486 EIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQT 545 IAERL+ DIT NWG+DES I+ID LTF I+TGQEE RRDGIETIEAIRELKKRHP V Sbjct 484 RIAERLLEDITVNWGLDESDIIIDALTFPISTGQEEVRRDGIETIEAIRELKKRHPRVHF 543 Query 546 TLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLV 605 TLG+SNISFGLNPAARQVLNSVFLHEC EAGLD+AIVHASKILPM RIP+EQR ALDLV Sbjct 544 TLGVSNISFGLNPAARQVLNSVFLHECTEAGLDTAIVHASKILPMARIPDEQRETALDLV 603 Query 606 YDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLD 665 YDRRRE YDPLQ+LM LFEGVSAAS++E R ELA LPLFERL +RIVDGERNGLD DL Sbjct 604 YDRRREGYDPLQKLMELFEGVSAASARESRAQELAALPLFERLERRIVDGERNGLDDDLT 663 Query 666 EAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDD 725 AM +KPPL IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME +D+ Sbjct 664 AAMEEKPPLAIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMEATDE 723 Query 726 DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVG 785 D GKGRIV+ATVKGDVHDIGKNLVDIILSNNGY+VVN+GIKQPIATIL+ A ++ ADV+G Sbjct 724 D-GKGRIVIATVKGDVHDIGKNLVDIILSNNGYDVVNLGIKQPIATILDAAIEQKADVIG 782 Query 786 MSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDA 845 MSGLLVKSTVVMK+NL+E+N +GVAEKFPVLLGGAALTRSYVENDLAE+Y+G+V YARDA Sbjct 783 MSGLLVKSTVVMKDNLQELNAKGVAEKFPVLLGGAALTRSYVENDLAEVYEGDVSYARDA 842 Query 846 FEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVP 905 FEGL MD IM+ KRG APD +SPEAI AREK AERKARH+RSKRIA +RKAAE PVE+P Sbjct 843 FEGLHKMDEIMAVKRGGAPDPDSPEAIAAREKAAERKARHERSKRIAEKRKAAEVPVELP 902 Query 906 ERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDL 965 ERSDVA DI VP+PPFWG+RIVKG++++DY+GLLDERALFLGQWGLRGQR G+GP+YE+L Sbjct 903 ERSDVATDIAVPSPPFWGNRIVKGVSLSDYSGLLDERALFLGQWGLRGQRSGDGPTYEEL 962 Query 966 VETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFP 1025 VETEGRPRLRYWLDRLST+GILAHAAVVYGYFPAVSEG+D+VVLT+P PDA R+RF FP Sbjct 963 VETEGRPRLRYWLDRLSTEGILAHAAVVYGYFPAVSEGDDVVVLTDPTPDAEERFRFTFP 1022 Query 1026 RQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVH 1085 RQ R RFLC+ADF+RSR A E G+VDV P QLVTMGQPIADFANELFA+NAYRDYLEVH Sbjct 1023 RQHRDRFLCVADFVRSRTEAKETGQVDVFPMQLVTMGQPIADFANELFAANAYRDYLEVH 1082 Query 1086 GIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPD 1145 GIGVQLTE+LAEYWH+R+REEL G + +DP +F L YRGAR++FGYGACP+ Sbjct 1083 GIGVQLTESLAEYWHQRVREELVLPGGHNVGEQDPSEVSGFFDLAYRGARYSFGYGACPN 1142 Query 1146 LEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LEDRAKM+ALLEPERIGV LSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1143 LEDRAKMVALLEPERIGVKLSEELQLHPEQSTDAFVLHHPEAKYFNV 1189 >gi|312139705|ref|YP_004007041.1| methionine synthase meth [Rhodococcus equi 103S] gi|311889044|emb|CBH48357.1| methionine synthase MetH [Rhodococcus equi 103S] Length=1192 Score = 1927 bits (4991), Expect = 0.0, Method: Compositional matrix adjust. Identities = 945/1187 (80%), Positives = 1051/1187 (89%), Gaps = 5/1187 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 + + LLD L QRV++GDGAMGT LQAADLTLDDF GLEGCNEILNETRPDVL IHR YF Sbjct 8 FHSALLDALKQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNETRPDVLRDIHRAYF 67 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK---RYVLG 125 EAGADAVETNTFGCNL NL DYDIA RIRDLS++GT IAR VADE+G P R R+VLG Sbjct 68 EAGADAVETNTFGCNLPNLADYDIAHRIRDLSERGTRIAREVADEMG-PGRDGMGRFVLG 126 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 SMGPGTKLPTLGH +AV+RDAYTE+ALGM++GGADAILVETCQDLLQ+KAA++GS+ AM Sbjct 127 SMGPGTKLPTLGHAPFAVLRDAYTESALGMIEGGADAILVETCQDLLQVKAAIIGSQHAM 186 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 + GR +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLRHL Sbjct 187 EKLGRRLPIITHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRHL 246 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 SRH+++PVSVMPNAGLP LG GAEYPL +ELA AL+GF++EFGLS VGGCCGTTP HI Sbjct 247 SRHSKLPVSVMPNAGLPQLGPNGAEYPLSAEELAVALSGFVSEFGLSFVGGCCGTTPEHI 306 Query 306 REVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAE 365 R+VA AV +++ +R E SSLY A+PF QDAS+L+IGERTN+NGSK FREAMIAE Sbjct 307 RQVADAVRRVEQAKRTPEPEDGTSSLYQAVPFDQDASILMIGERTNSNGSKAFREAMIAE 366 Query 366 DYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVL 425 DYQKC+DIAKDQTRDGAH+LDL VDYVGRDG ADM ALASR AT+STLPIMLDSTE VL Sbjct 367 DYQKCIDIAKDQTRDGAHMLDLNVDYVGRDGAADMAALASRFATASTLPIMLDSTEPEVL 426 Query 426 QAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKV 485 +AGLEHLGGRCA+NSVNYEDGDGP SR+ + M LV EHGAAVVALTIDEEGQARTA+ KV Sbjct 427 RAGLEHLGGRCAVNSVNYEDGDGPNSRYQRIMKLVKEHGAAVVALTIDEEGQARTAEHKV 486 Query 486 EIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQT 545 IAERLI DIT WG+ +S I+ID LTF I+TGQEE RRDGIETIEAIRE+K+R+PDV Sbjct 487 RIAERLIQDITTTWGLSQSDIIIDALTFPISTGQEEVRRDGIETIEAIREIKRRYPDVHF 546 Query 546 TLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLV 605 TLG+SNISFGLNPAARQVLNSVFLHEC EAGLD+AIVHASKILPM RIP+EQR ALDLV Sbjct 547 TLGISNISFGLNPAARQVLNSVFLHECTEAGLDTAIVHASKILPMARIPDEQRETALDLV 606 Query 606 YDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLD 665 YDRRRE YDPLQ+LM LFEGVSAAS++E R ELA LPLFERL +RIVDGERNGL+ADLD Sbjct 607 YDRRREGYDPLQKLMELFEGVSAASARESRAEELAALPLFERLERRIVDGERNGLEADLD 666 Query 666 EAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDD 725 AM ++PPL+IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME S Sbjct 667 AAMVERPPLEIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME-STG 725 Query 726 DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVG 785 D GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATIL+VA DK ADV+G Sbjct 726 DEGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILDVALDKKADVIG 785 Query 786 MSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDA 845 MSGLLVKSTVVMKENLEE+N +GVAE+FPVLLGGAALTRSYVENDL+++YQGEV YARDA Sbjct 786 MSGLLVKSTVVMKENLEELNAKGVAEQFPVLLGGAALTRSYVENDLSDVYQGEVSYARDA 845 Query 846 FEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVP 905 FEGL LMDTIM+ KRGE P +SPEAI A EK AERKARH+RSKRIA +RKA PVEVP Sbjct 846 FEGLHLMDTIMAVKRGEGPAPDSPEAIAAAEKAAERKARHERSKRIAEKRKAESAPVEVP 905 Query 906 ERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDL 965 ERSDVAADI VP PPFWG+RIVKG+A+A+Y+GLLDERALFLGQWGLRGQR G+GP+YE+L Sbjct 906 ERSDVAADIVVPTPPFWGTRIVKGIALAEYSGLLDERALFLGQWGLRGQRAGDGPTYEEL 965 Query 966 VETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFP 1025 VETEGRPRLRYWLDRLST+G+L HAAVVYGYFPAVSEG+D++VL P PDAP R+RF FP Sbjct 966 VETEGRPRLRYWLDRLSTEGVLQHAAVVYGYFPAVSEGDDVIVLESPDPDAPERFRFTFP 1025 Query 1026 RQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVH 1085 RQQR RFLCIADF+RSR+ A + G+VDVLP LVTMGQPIADFANELFA+N+YRDYLEVH Sbjct 1026 RQQRDRFLCIADFVRSRDDARKDGQVDVLPMNLVTMGQPIADFANELFAANSYRDYLEVH 1085 Query 1086 GIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPD 1145 GIGVQLTEALAEYWHRR+REEL G +A +DP ED+FKL YRGAR++FGYGACPD Sbjct 1086 GIGVQLTEALAEYWHRRVREELVLPGGHNLAEQDPSDVEDFFKLEYRGARYSFGYGACPD 1145 Query 1146 LEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LEDR K++ALLEPERIGV LSEE+QLHPEQSTDAFVLHHPEAKYFNV Sbjct 1146 LEDRRKLVALLEPERIGVELSEEVQLHPEQSTDAFVLHHPEAKYFNV 1192 >gi|325676845|ref|ZP_08156518.1| 5-methyltetrahydrofolate-homocysteine methyltransferase [Rhodococcus equi ATCC 33707] gi|325552393|gb|EGD22082.1| 5-methyltetrahydrofolate-homocysteine methyltransferase [Rhodococcus equi ATCC 33707] Length=1189 Score = 1926 bits (4989), Expect = 0.0, Method: Compositional matrix adjust. Identities = 945/1187 (80%), Positives = 1052/1187 (89%), Gaps = 5/1187 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 + + LLD L QRV++GDGAMGT LQAADLTLDDF GLEGCNEILNETRPDVL IHR YF Sbjct 5 FHSALLDALKQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNETRPDVLRDIHRAYF 64 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK---RYVLG 125 EAGADAVETNTFGCNL NL DYDIA RIRDLS++GT IAR VADE+G P R R+VLG Sbjct 65 EAGADAVETNTFGCNLPNLADYDIAHRIRDLSERGTRIAREVADEMG-PGRDGMGRFVLG 123 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 SMGPGTKLPTLGH +AV+RDAYTE+ALGM++GGADAILVETCQDLLQ+KAA++GS+ AM Sbjct 124 SMGPGTKLPTLGHAPFAVLRDAYTESALGMIEGGADAILVETCQDLLQVKAAIIGSQHAM 183 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 + GR +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLRHL Sbjct 184 EKLGRRLPIITHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRHL 243 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 SRH+++PVSVMPNAGLP LG GAEYPL +ELA AL+GF++EFGLS VGGCCGTTP HI Sbjct 244 SRHSKLPVSVMPNAGLPQLGPNGAEYPLSAEELAVALSGFVSEFGLSFVGGCCGTTPEHI 303 Query 306 REVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAE 365 R+VA AV +++ +R E SSLY A+PF QDAS+L+IGERTN+NGSK FREAMIAE Sbjct 304 RQVADAVRRVEQAKRTPEPEDGTSSLYQAVPFDQDASILMIGERTNSNGSKAFREAMIAE 363 Query 366 DYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVL 425 DYQKC+DIAKDQTRDGAH+LDL VDYVGRDG ADM ALASR AT+STLPIMLDSTE VL Sbjct 364 DYQKCIDIAKDQTRDGAHMLDLNVDYVGRDGAADMAALASRFATASTLPIMLDSTEPEVL 423 Query 426 QAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKV 485 +AGLEHLGGRCA+NSVNYEDGDGP SR+ + M LV EHGAAVVALTIDEEGQARTA+ KV Sbjct 424 RAGLEHLGGRCAVNSVNYEDGDGPNSRYQRIMKLVKEHGAAVVALTIDEEGQARTAEHKV 483 Query 486 EIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQT 545 IAERLI DIT WG+ +S I+ID LTF I+TGQEE RRDGIETIEAIRE+K+R+PDV Sbjct 484 RIAERLIQDITTTWGLSQSDIIIDALTFPISTGQEEVRRDGIETIEAIREIKRRYPDVHF 543 Query 546 TLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLV 605 TLG+SNISFGLNPAARQVLNSVFLHEC EAGLD+AIVHASKILPM RIP+EQR ALDLV Sbjct 544 TLGISNISFGLNPAARQVLNSVFLHECTEAGLDTAIVHASKILPMARIPDEQRETALDLV 603 Query 606 YDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLD 665 YDRRRE YDPLQ+LM LFEGVSAAS++E R ELA LPLFERL +RIVDGERNGL+ADLD Sbjct 604 YDRRREGYDPLQKLMELFEGVSAASARESRAEELAALPLFERLERRIVDGERNGLEADLD 663 Query 666 EAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDD 725 AM ++PPL+IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME S Sbjct 664 AAMVERPPLEIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHME-STG 722 Query 726 DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVG 785 D GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATIL+VA DK ADV+G Sbjct 723 DEGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILDVALDKKADVIG 782 Query 786 MSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDA 845 MSGLLVKSTVVMKENLEE+N +GVAE+FPVLLGGAALTRSYVENDL+++YQGEV YARDA Sbjct 783 MSGLLVKSTVVMKENLEELNAKGVAEQFPVLLGGAALTRSYVENDLSDVYQGEVSYARDA 842 Query 846 FEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVP 905 FEGL LMDTIM+ KRGE P +SPEAI A EK AERKARH+RSKRIA +RKA PVEVP Sbjct 843 FEGLHLMDTIMAVKRGEGPAPDSPEAIAAAEKAAERKARHERSKRIAEKRKAESAPVEVP 902 Query 906 ERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDL 965 ERSDVAADI VP+PPFWG+RIVKG+A+A+Y+GLLDERALFLGQWGLRGQR G+GP+YE+L Sbjct 903 ERSDVAADIVVPSPPFWGTRIVKGIALAEYSGLLDERALFLGQWGLRGQRAGDGPTYEEL 962 Query 966 VETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFP 1025 VETEGRPRLRYWLDRLST+G+L HAAVVYGYFPAVSEG+D++VL P PDAP R+RF FP Sbjct 963 VETEGRPRLRYWLDRLSTEGVLQHAAVVYGYFPAVSEGDDVIVLESPDPDAPERFRFTFP 1022 Query 1026 RQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVH 1085 RQQR RFLCIADF+RSR+ A + G+VDVLP LVTMGQPIADFANELFA+N+YRDYLEVH Sbjct 1023 RQQRDRFLCIADFVRSRDDARKDGQVDVLPMNLVTMGQPIADFANELFAANSYRDYLEVH 1082 Query 1086 GIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPD 1145 GIGVQLTEALAEYWHRR+REEL G +A +DP ED+FKL YRGAR++FGYGACPD Sbjct 1083 GIGVQLTEALAEYWHRRVREELVLPGGHNLAEQDPSDVEDFFKLEYRGARYSFGYGACPD 1142 Query 1146 LEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LEDR K++ALLEPERIGV LSEE+QLHPEQSTDAFVLHHPEAKYFNV Sbjct 1143 LEDRRKLVALLEPERIGVELSEEVQLHPEQSTDAFVLHHPEAKYFNV 1189 >gi|226306676|ref|YP_002766636.1| methionine synthase [Rhodococcus erythropolis PR4] gi|226185793|dbj|BAH33897.1| methionine synthase [Rhodococcus erythropolis PR4] Length=1189 Score = 1915 bits (4960), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1187 (79%), Positives = 1053/1187 (89%), Gaps = 5/1187 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 +++ LLD L QRV++GDGAMGT LQAADLTLDDF GLEGCNEILN+TRPDVL+ IHR YF Sbjct 5 FNSALLDALKQRVVIGDGAMGTMLQAADLTLDDFLGLEGCNEILNDTRPDVLKDIHRAYF 64 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK---RYVLG 125 AGADAVETNTFGCNL NL DYDI+ RIR+L++KGTA+AR VADE+G P R R+VLG Sbjct 65 AAGADAVETNTFGCNLPNLADYDISHRIRELAEKGTALAREVADEMG-PGRDGMARFVLG 123 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 SMGPGTKLP+LGH YAV+RDAYTEAALGM+DGGADAILVETCQDLLQ+KAA+LGS+RAM Sbjct 124 SMGPGTKLPSLGHAPYAVLRDAYTEAALGMIDGGADAILVETCQDLLQVKAAILGSQRAM 183 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 + G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGPAEMSEHLRHL Sbjct 184 EQLGLRLPIITHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPAEMSEHLRHL 243 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 S+++ +PVSVMPNAGLP LG KGAEYPL DELAEAL+GF++EFGL LVGGCCGTTP HI Sbjct 244 SKYSTLPVSVMPNAGLPQLGPKGAEYPLTADELAEALSGFVSEFGLGLVGGCCGTTPEHI 303 Query 306 REVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAE 365 VA AV +++ +R +EPS SSLY+A+PF QDAS+L+IGERTN+NGSK FREAM++ Sbjct 304 SAVADAVRQVEKAQRTPIHEPSTSSLYSAVPFEQDASILMIGERTNSNGSKAFREAMLSA 363 Query 366 DYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVL 425 DYQKCLDIAKDQTRDGAH+LDL VDYVGRDG ADM LASRLATSSTLPIMLDSTE AVL Sbjct 364 DYQKCLDIAKDQTRDGAHMLDLNVDYVGRDGAADMSELASRLATSSTLPIMLDSTEPAVL 423 Query 426 QAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKV 485 QAGLEHLGGRCA+NSVNYEDG GPESRF K M LV EHGAAVVALTIDEEGQARTA+ KV Sbjct 424 QAGLEHLGGRCAVNSVNYEDGAGPESRFHKIMTLVKEHGAAVVALTIDEEGQARTAETKV 483 Query 486 EIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQT 545 IA+RLI DI GNWG+ ES I++D LTF I+TGQEE RRDGIETIEAIR+LK +P++ Sbjct 484 AIAKRLIEDIKGNWGLAESDIIVDALTFPISTGQEEVRRDGIETIEAIRQLKAAYPELHF 543 Query 546 TLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLV 605 TLG+SNISFGLNPAARQVLNSVFLHEC EAGLD+AIVHASKILPM RIP+EQR ALDLV Sbjct 544 TLGISNISFGLNPAARQVLNSVFLHECTEAGLDTAIVHASKILPMARIPDEQRETALDLV 603 Query 606 YDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLD 665 YDRR E YDPLQ+LM LFEGVSAAS++E R ELAGLPLF+RL +RIVDGERNGLD DL Sbjct 604 YDRRSEGYDPLQKLMALFEGVSAASARESRAQELAGLPLFDRLERRIVDGERNGLDDDLT 663 Query 666 EAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDD 725 EAMT K P++IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVA+LEPHME +DD Sbjct 664 EAMTVKSPIEIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAFLEPHMEATDD 723 Query 726 DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVG 785 D GKGR+V+ATVKGDVHDIGKNLVDIILSNNGY+VVN+GIKQPIATIL+ A + ADV+G Sbjct 724 D-GKGRLVIATVKGDVHDIGKNLVDIILSNNGYDVVNLGIKQPIATILDAAIEHKADVIG 782 Query 786 MSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDA 845 MSGLLVKSTVVMK+NL+E+N+RGV+E+FPVLLGGAALTRSYVENDL E+Y+G+V YARDA Sbjct 783 MSGLLVKSTVVMKDNLKELNSRGVSEQFPVLLGGAALTRSYVENDLQEVYEGDVSYARDA 842 Query 846 FEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVP 905 FEGL LMD IM+ KRG P +SPEAI AREK AERKARH+RSKRIA +RKAA PV +P Sbjct 843 FEGLNLMDQIMTTKRGGGPAPDSPEAIAAREKAAERKARHERSKRIAEKRKAAAVPVVLP 902 Query 906 ERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDL 965 ERSDVA DI VP PPFWGSRIVKG+++++Y+GLLDERALFLGQWGLRGQR G+GP+YE+L Sbjct 903 ERSDVATDIAVPTPPFWGSRIVKGISLSEYSGLLDERALFLGQWGLRGQRKGDGPTYEEL 962 Query 966 VETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFP 1025 VE+EGRPRLRYWLDRL+++GILAHAAVVYGYFPA+SEG+D++VLTEPKPDAP R+RF +P Sbjct 963 VESEGRPRLRYWLDRLTSEGILAHAAVVYGYFPAISEGDDVIVLTEPKPDAPERFRFTYP 1022 Query 1026 RQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVH 1085 RQ R RFLCIADF+RSR+ A G+VDVLPFQLVTMGQPIADFANELFASN+YRDYLEVH Sbjct 1023 RQHRDRFLCIADFVRSRKEAEATGQVDVLPFQLVTMGQPIADFANELFASNSYRDYLEVH 1082 Query 1086 GIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPD 1145 GIGVQLTE+LAEYWHRR+REEL +A +DP YF L YRGAR++FGYGACPD Sbjct 1083 GIGVQLTESLAEYWHRRVREELVLPEGHTVAEQDPTEVAGYFDLEYRGARYSFGYGACPD 1142 Query 1146 LEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LEDRAK++ALLEPERIGV LSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1143 LEDRAKLVALLEPERIGVELSEELQLHPEQSTDAFVLHHPEAKYFNV 1189 >gi|333919631|ref|YP_004493212.1| methionine synthase [Amycolicicoccus subflavus DQS3-9A1] gi|333481852|gb|AEF40412.1| Methionine synthase [Amycolicicoccus subflavus DQS3-9A1] Length=1187 Score = 1891 bits (4899), Expect = 0.0, Method: Compositional matrix adjust. Identities = 909/1184 (77%), Positives = 1032/1184 (88%), Gaps = 3/1184 (0%) Query 11 TDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEA 70 T LLD L+QRV++GDGAMGT LQAA LTLDDFR LEGCNEILN+TRPDVL IH Y EA Sbjct 5 TSLLDALTQRVVIGDGAMGTMLQAAHLTLDDFRELEGCNEILNDTRPDVLREIHLAYLEA 64 Query 71 GADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELG-SPD-RKRYVLGSMG 128 GADA+ETNTFGCNL NL DYDIADRIR+L++KGT IAR ADE G S D R++LGS+G Sbjct 65 GADAIETNTFGCNLPNLADYDIADRIRELAEKGTRIAREAADETGPSADGMPRFILGSVG 124 Query 129 PGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRA 188 PGTKLPTLGH +A +RDAY E ALGM+DGGADAIL+ETCQDLLQ+KAA++G++ AM +A Sbjct 125 PGTKLPTLGHAPFASLRDAYAECALGMIDGGADAILIETCQDLLQVKAAIIGAQHAMDQA 184 Query 189 GRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRH 248 +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+D+IGLNCATGP EMSEHLRHLS+H Sbjct 185 NTRLPIITHVTVETTGTMLLGSEIGAALTALEPLGIDLIGLNCATGPEEMSEHLRHLSKH 244 Query 249 ARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREV 308 +R+PVSVMPNAGLPVLGA GAEYPL +EL AL+GF+ EFGL+LVGGCCGTTP HIR++ Sbjct 245 SRLPVSVMPNAGLPVLGANGAEYPLTAEELGVALSGFVREFGLALVGGCCGTTPEHIRQL 304 Query 309 AAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQ 368 AAV ++ ER EP V+SLY+ +PF QD+S+L+IGERTNANGSK FREAM+A D+Q Sbjct 305 RAAVLETRQAERHPRPEPGVASLYSHVPFKQDSSILMIGERTNANGSKAFREAMLAGDFQ 364 Query 369 KCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAG 428 KCLDIAKDQTRDGAH+LDLC+DYVGR+G DM LASRLATSSTLPIMLDSTE VL+AG Sbjct 365 KCLDIAKDQTRDGAHMLDLCIDYVGRNGAEDMSELASRLATSSTLPIMLDSTEPEVLRAG 424 Query 429 LEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIA 488 LEHLGGRCAINSVNYEDGDGP+SRF + M LV EHGAAVVAL IDE GQARTA+ KV +A Sbjct 425 LEHLGGRCAINSVNYEDGDGPDSRFYRIMRLVKEHGAAVVALCIDENGQARTAEDKVRVA 484 Query 489 ERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLG 548 ERLI+DITGNWG+ + I++D LTFTI TG EESR+DG TIEAIR+LK+R P V TTLG Sbjct 485 ERLIDDITGNWGLRDEDIIVDCLTFTIGTGMEESRKDGAATIEAIRQLKERRPRVHTTLG 544 Query 549 LSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDR 608 LSNISFGLNPAARQVLNSVFLHEC EAGLD+AIVHASKILPM++I EEQR VALDLVYDR Sbjct 545 LSNISFGLNPAARQVLNSVFLHECVEAGLDTAIVHASKILPMSKIGEEQREVALDLVYDR 604 Query 609 RREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAM 668 RRE YDPLQ+ M LFEGVSAAS++E R +LA LPLFERL +RI+DGERNGLD DL+EAM Sbjct 605 RREGYDPLQKFMDLFEGVSAASARESRAQQLAALPLFERLERRIIDGERNGLDTDLEEAM 664 Query 669 TQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG 728 +KPPL IINE+LLAGMK VGELFGSGQMQLPFVL SAEVMK AVA+LEPHME + DSG Sbjct 665 KEKPPLAIINENLLAGMKVVGELFGSGQMQLPFVLTSAEVMKTAVAHLEPHME-ATGDSG 723 Query 729 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSG 788 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEV+N+GIKQPIA IL+ A +K ADV+GMSG Sbjct 724 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVINLGIKQPIANILDAAVEKKADVIGMSG 783 Query 789 LLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEG 848 LLVKSTVVMKENLEE+N+RG A+KFPVLLGGAALTRSYVENDL +Y G+V YARDAFEG Sbjct 784 LLVKSTVVMKENLEELNSRGFADKFPVLLGGAALTRSYVENDLTAVYHGDVLYARDAFEG 843 Query 849 LKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERS 908 L+LMDTIM+ KRGE PD NSPEA+ AREKE ERKARH+RSKRIA +RKA + PV VPERS Sbjct 844 LRLMDTIMAEKRGEGPDPNSPEAVAAREKEEERKARHERSKRIAEKRKAEQAPVVVPERS 903 Query 909 DVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVET 968 DVA D++VP PPFWG+RIVKG+++A+Y+ LDERALFLGQWGLRG RGGEGPSYE+LVE+ Sbjct 904 DVAEDLDVPVPPFWGTRIVKGISLAEYSTTLDERALFLGQWGLRGVRGGEGPSYEELVES 963 Query 969 EGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQ 1028 EGRPRLRYWLDRLST+GILAHAAVVYGYFPAVSEG+ + VL P+PDAPVR+ F FPRQQ Sbjct 964 EGRPRLRYWLDRLSTEGILAHAAVVYGYFPAVSEGDSVFVLESPEPDAPVRFEFEFPRQQ 1023 Query 1029 RGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIG 1088 R RFLC++DF+RSR A +VDVLPFQLVTMGQPIADFANELFA + YRDYLEVHGIG Sbjct 1024 RDRFLCVSDFVRSRARARATNQVDVLPFQLVTMGQPIADFANELFAEDQYRDYLEVHGIG 1083 Query 1089 VQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLED 1148 VQLTEALAEYWH+R+REEL A+A EDP +++F+LGYRGAR++FGYGACP+LED Sbjct 1084 VQLTEALAEYWHQRVREELIMPSGAAVAREDPADVQEFFRLGYRGARYSFGYGACPNLED 1143 Query 1149 RAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 R K++ LLEP RIGV LSEELQLHPEQSTDAFVLHHPEAKYFNV Sbjct 1144 RVKLVELLEPGRIGVALSEELQLHPEQSTDAFVLHHPEAKYFNV 1187 >gi|262202371|ref|YP_003273579.1| methionine synthase [Gordonia bronchialis DSM 43247] gi|262085718|gb|ACY21686.1| methionine synthase [Gordonia bronchialis DSM 43247] Length=1199 Score = 1874 bits (4854), Expect = 0.0, Method: Compositional matrix adjust. Identities = 944/1192 (80%), Positives = 1040/1192 (88%), Gaps = 4/1192 (0%) Query 3 AADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLET 62 + D +DT + +S+RV++GDGAMGT LQAADLTLDDF GLEGCNEILN+ RPDVLE Sbjct 10 STDPADFDTTFMSAMSRRVLIGDGAMGTMLQAADLTLDDFNGLEGCNEILNDARPDVLEG 69 Query 63 IHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELG--SPDRK 120 IHR YFEAGADAVETNTFGCNLSNLGDYDIADRIR+L+ KGT IAR VADE+G + Sbjct 70 IHRAYFEAGADAVETNTFGCNLSNLGDYDIADRIRELAYKGTGIARGVADEMGPTANGTD 129 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 R+VLGS+GPGTKLP+LGHT +AVIRDAY E GMLDGGADAIL+ET QDLLQ+KAAV+ Sbjct 130 RFVLGSIGPGTKLPSLGHTTFAVIRDAYFECVAGMLDGGADAILIETSQDLLQVKAAVVA 189 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 +RRAM + GR IP+ +HVTVETTGTMLLGSEIGAALTA+EPLGVDMIGLNCATGPAEMSE Sbjct 190 ARRAMDKLGRRIPIISHVTVETTGTMLLGSEIGAALTAIEPLGVDMIGLNCATGPAEMSE 249 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLR+LSRHARIPVSVMPNAGLPVLG GAEYPL P+ELA+AL GF+AEFGL VGGCCGT Sbjct 250 HLRYLSRHARIPVSVMPNAGLPVLGPNGAEYPLSPEELAQALHGFVAEFGLDFVGGCCGT 309 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TP HIR+VA AV R + SSLYTA+PF QDAS LVIGERTN NGSK FRE Sbjct 310 TPEHIRQVAEAVHGATPAARTPEHASETSSLYTAVPFDQDASFLVIGERTNTNGSKAFRE 369 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIA DYQ+CLDIAKDQTRDGAH+LDL VDYVGRDG DM ALASR ATSSTLPIMLDST Sbjct 370 AMIAGDYQRCLDIAKDQTRDGAHMLDLNVDYVGRDGAVDMTALASRFATSSTLPIMLDST 429 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 E V++AGLE LGGRCA+NSVNYEDGDGP SRF + M LV EHGAAVVALTIDEEGQART Sbjct 430 EPEVIRAGLETLGGRCAVNSVNYEDGDGPNSRFTRIMQLVVEHGAAVVALTIDEEGQART 489 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 A KV IAERLI DITGNWG+ E I+ID LTF I+TGQEE RRDGIETIEAIR + + H Sbjct 490 ADWKVRIAERLIADITGNWGLAEEDIIIDALTFPISTGQEEVRRDGIETIEAIRRIHEAH 549 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 P+V TLG+SNISFGLNPAARQVLNSVFLHEC +AGLD+AIVHASKILPM RIPEE R V Sbjct 550 PEVHFTLGISNISFGLNPAARQVLNSVFLHECVQAGLDTAIVHASKILPMARIPEEHRKV 609 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRR YDPLQ+LM LFEGVSAAS++E R AELA LPLFERL +RIVDGERNGL Sbjct 610 ALDLVYDRRAPGYDPLQKLMELFEGVSAASARESRAAELAKLPLFERLERRIVDGERNGL 669 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 + DLDEAMT PPL+IINE LL+GMKTVGELFGSGQMQLPFVLQSAEVMK AVA+LEPHM Sbjct 670 EDDLDEAMTTVPPLKIINETLLSGMKTVGELFGSGQMQLPFVLQSAEVMKTAVAHLEPHM 729 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 E + +D GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPI IL+VA DK Sbjct 730 ESTGED-GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPITNILDVAADKK 788 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 DV+GMSGLLVKSTVVMKENLEE+N RG+A+++PVLLGGAALTRSYVENDL+E Y+G+VH Sbjct 789 VDVIGMSGLLVKSTVVMKENLEEINARGLADEYPVLLGGAALTRSYVENDLSETYEGDVH 848 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE 900 YARDAFEGL+LMD IM+ KRGE PD +SPEAI A EK AERKARH RSKRIAA+RKAAEE Sbjct 849 YARDAFEGLRLMDEIMATKRGEGPDPDSPEAIAAAEKAAERKARHDRSKRIAAKRKAAEE 908 Query 901 PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP 960 PVEVP RSDVAAD ++PAPPFWG+RIVKG+ VADY LLDERALFLGQWGLRG RGG+GP Sbjct 909 PVEVPARSDVAADNDIPAPPFWGTRIVKGVPVADYLQLLDERALFLGQWGLRGARGGDGP 968 Query 961 SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY 1020 SYEDLVE+EGRPRLRYW+DRL+T+GIL HAAVVYGYFPAVS+G+ + VLTEP+PDAPVRY Sbjct 969 SYEDLVESEGRPRLRYWIDRLATEGILQHAAVVYGYFPAVSDGDTVHVLTEPRPDAPVRY 1028 Query 1021 RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD 1080 F FPRQQR RFLCIADFIRSRE A G VDVLPFQLVTMGQPIADFANELFA++AYRD Sbjct 1029 SFGFPRQQRSRFLCIADFIRSREDAIRDGHVDVLPFQLVTMGQPIADFANELFAADAYRD 1088 Query 1081 YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY 1140 YLEVHGIGVQLTEALAEYWH+R+R EL+F G+R M +EDP+ + +F L YRGARF+FGY Sbjct 1089 YLEVHGIGVQLTEALAEYWHQRVRSELRF-GERTMDSEDPDEAQGFFDLEYRGARFSFGY 1147 Query 1141 GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GACPDL+DRAKMM LL+PERIGV LSEELQLHPEQSTDAFVLHHPEAKYFN Sbjct 1148 GACPDLDDRAKMMELLQPERIGVHLSEELQLHPEQSTDAFVLHHPEAKYFNT 1199 >gi|256376339|ref|YP_003099999.1| methionine synthase [Actinosynnema mirum DSM 43827] gi|255920642|gb|ACU36153.1| methionine synthase [Actinosynnema mirum DSM 43827] Length=1178 Score = 1782 bits (4615), Expect = 0.0, Method: Compositional matrix adjust. Identities = 868/1181 (74%), Positives = 1002/1181 (85%), Gaps = 10/1181 (0%) Query 11 TDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEA 70 + LLD L++RV+V DGAMGT LQ+ DL+LDDF G EGCNEILN TRPDV+ +HR Y EA Sbjct 7 SPLLDALTERVVVADGAMGTMLQSFDLSLDDFAGHEGCNEILNTTRPDVVRAVHRGYLEA 66 Query 71 GADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPG 130 GADAVETNTFG NLSN DY I DRI +LS+ G +AR ADE P R R+VLGS+GPG Sbjct 67 GADAVETNTFGANLSNFSDYGIQDRIFELSRLGAQLAREAADEHSEPGRPRFVLGSVGPG 126 Query 131 TKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGR 190 +KLPTLGH Y+V+RD+Y E G+L GG+DAI+VET QDLLQ KAA++G+RRAM G Sbjct 127 SKLPTLGHVAYSVLRDSYVEQIRGLLVGGSDAIIVETSQDLLQTKAAIVGARRAMDAEGL 186 Query 191 HIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHAR 250 +P+ A VTVETTGTMLLGSEIGAALTA+EPLG+D++GLNCATGPAEMSEHLRH+++HAR Sbjct 187 RVPIIAQVTVETTGTMLLGSEIGAALTALEPLGIDLVGLNCATGPAEMSEHLRHIAKHAR 246 Query 251 IPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAA 310 IP+SVMPNAGLP LG GA YPL P+ELA+AL GF EFG LVGGCCGTT H+R+VAA Sbjct 247 IPLSVMPNAGLPQLGPNGAVYPLGPEELAQALRGFATEFGARLVGGCCGTTAEHVRQVAA 306 Query 311 AVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKC 370 AV ++ R+ EP VSSLY A+PF QDASVL+IGERTNANGSK FREAM+A+ + C Sbjct 307 AVRDLGPTTRRPRPEPGVSSLYQAVPFQQDASVLMIGERTNANGSKAFREAMLADRWDDC 366 Query 371 LDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLE 430 + IA+DQTRDGAHL+DL +DYVGRDGVADM ALASRLAT+STLPIMLDSTE VLQAGLE Sbjct 367 VGIARDQTRDGAHLIDLNIDYVGRDGVADMSALASRLATASTLPIMLDSTEPEVLQAGLE 426 Query 431 HLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAER 490 HLGGRCA+NSVNYEDGDGP+SRF + M LVAEHGAAVV L IDEEGQARTA+ KV +A R Sbjct 427 HLGGRCAVNSVNYEDGDGPDSRFQRIMRLVAEHGAAVVGLCIDEEGQARTAEWKVRVAIR 486 Query 491 LINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLS 550 +I D+ GNWG+ I+ID LTF I+TGQEE RRDG+ETIEAIRELK+R+P+V+TTLGLS Sbjct 487 IIEDLVGNWGLRHGDIIIDCLTFPISTGQEEVRRDGVETIEAIRELKRRYPEVRTTLGLS 546 Query 551 NISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRR 610 N+SFGLNPAARQVLNSVFLHEC +AGLD+AIVHASKI+PM RIP+EQR VALDLVYDRRR Sbjct 547 NVSFGLNPAARQVLNSVFLHECVQAGLDTAIVHASKIVPMARIPDEQRAVALDLVYDRRR 606 Query 611 EDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQ 670 E YDPLQ LM LFEGV+ ++SK R ELA LPLFERL +RIVDGERNGL+ADLDEA+T+ Sbjct 607 EGYDPLQRLMELFEGVTTSASKATRAQELAALPLFERLQRRIVDGERNGLEADLDEALTR 666 Query 671 KPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKG 730 +P LQIIN+ LLAGMKTVGELFGSGQMQLPFVLQSAEVMK AVA+LEPHMERS DD GKG Sbjct 667 RPALQIINDTLLAGMKTVGELFGSGQMQLPFVLQSAEVMKTAVAHLEPHMERS-DDGGKG 725 Query 731 RIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLL 790 RIVLATVKGDVHDIGKNLVDIILSNNGYEV+N+GIKQPI+ IL+ AE+ AD +GMSGLL Sbjct 726 RIVLATVKGDVHDIGKNLVDIILSNNGYEVINLGIKQPISAILDAAENHRADAIGMSGLL 785 Query 791 VKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLK 850 VKSTV+MKENLEEMN+RGVA ++PVLLGGAALTR+YVENDL + Y GEV YARDAFEGL+ Sbjct 786 VKSTVIMKENLEEMNSRGVAARWPVLLGGAALTRAYVENDLTDTYLGEVRYARDAFEGLR 845 Query 851 LMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDV 910 LMD +M+AKRGE+P + PEA + K AERKAR +RS RIAA+RKAA+ E RSDV Sbjct 846 LMDAVMAAKRGESPLID-PEAER---KAAERKARRERSLRIAAERKAAQPEPEPVSRSDV 901 Query 911 AADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEG 970 AAD+ VP PPFWG+R+VKG+ + DY+ LLDERA F+GQWGLRG R G GPSYE+LVETEG Sbjct 902 AADLPVPTPPFWGTRVVKGVPLGDYSALLDERATFMGQWGLRGSR-GSGPSYEELVETEG 960 Query 971 RPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRG 1030 RPRLRYWL+RL+T+G+LAHAAVVYGYFP VSEG+ +V+L EP DAP RF FPRQ+R Sbjct 961 RPRLRYWLERLATEGVLAHAAVVYGYFPCVSEGDSLVILGEPSVDAPEVTRFAFPRQKRD 1020 Query 1031 RFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQ 1090 R LC+ADF R R E GEVDV+PFQLVTMGQPIAD+ANELFA +AYR+YLEVHG+GVQ Sbjct 1021 RRLCLADFWRPR----ESGEVDVVPFQLVTMGQPIADYANELFAKDAYREYLEVHGLGVQ 1076 Query 1091 LTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRA 1150 LTEALAEYWH+R+REEL + G +AAEDP E+YFKLGYRGAR++ GYGACPD+EDR Sbjct 1077 LTEALAEYWHKRVREELTWPGGGVVAAEDPADVEEYFKLGYRGARYSLGYGACPDMEDRT 1136 Query 1151 KMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 K++ALLEP RIGV LSEELQLHPEQSTDAF+ HHPEAKYFN Sbjct 1137 KVVALLEPGRIGVKLSEELQLHPEQSTDAFIAHHPEAKYFN 1177 >gi|25028193|ref|NP_738247.1| putative 5-methyltetrahydrofolate--homocysteine methyltransferase [Corynebacterium efficiens YS-314] gi|259507251|ref|ZP_05750151.1| methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase) (methionine synthase, vitamin-B12 dependent) [Corynebacterium efficiens YS-314] gi|23493477|dbj|BAC18447.1| putative 5-methyltetrahydrofolate--homocysteine methyltransferase [Corynebacterium efficiens YS-314] gi|259165194|gb|EEW49748.1| methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase) (methionine synthase, vitamin-B12 dependent) [Corynebacterium efficiens YS-314] Length=1213 Score = 1777 bits (4603), Expect = 0.0, Method: Compositional matrix adjust. Identities = 863/1206 (72%), Positives = 997/1206 (83%), Gaps = 28/1206 (2%) Query 13 LLDVLSQRVMVGDGAMGTQLQAADLTL-DDFRGLEGCNEILNETRPDVLETIHRNYFEAG 71 LD L V++GDGAMGTQLQA DL + DDF GLEGCNEILN TRPDVL IHR YFEAG Sbjct 10 FLDALRSHVLIGDGAMGTQLQAFDLDVEDDFLGLEGCNEILNHTRPDVLRQIHRAYFEAG 69 Query 72 ADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVLGSMG 128 AD VETNTFGCNL NL DYDIADR R+L+ KGTA+AR VADE+G P R +R+V+GS+G Sbjct 70 ADLVETNTFGCNLPNLADYDIADRCRELAYKGTAVAREVADEMG-PGRNGMRRFVVGSLG 128 Query 129 PGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRA 188 PGTKLP+LGH Y +R Y EAALG+++GG DA L+ET QDLLQ+KAAV G + AMT Sbjct 129 PGTKLPSLGHAPYGDLRGHYKEAALGIIEGGGDAFLIETAQDLLQVKAAVHGVQDAMTEL 188 Query 189 GRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRH 248 G +P+ HVTVETTGTML+GSEIGAALTA+EPLG+DMIGLNCATGPAEMSEHLR+LS+H Sbjct 189 GVTLPIICHVTVETTGTMLMGSEIGAALTALEPLGIDMIGLNCATGPAEMSEHLRYLSKH 248 Query 249 ARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREV 308 A IPVSVMPNAGLPVLG GAEYPL +ELAEAL GF+ ++GLS+VGGCCGTTP HIR V Sbjct 249 ASIPVSVMPNAGLPVLGKNGAEYPLTAEELAEALRGFVTDYGLSMVGGCCGTTPEHIRAV 308 Query 309 AAAVANI----------------KRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNA 352 AV + +R ER++ E +V+SLYT++P +Q + +IGERTNA Sbjct 309 RDAVVGVPEGETSALESVPVGPVERAEREIEVEDAVASLYTSVPLSQGTGITMIGERTNA 368 Query 353 NGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSST 412 NGS+ FREAM+A D++KC+DIAK QTRDGAH+LDLCVDYVGRDG DM LAS LATSST Sbjct 369 NGSRAFREAMLAGDWEKCVDIAKQQTRDGAHMLDLCVDYVGRDGREDMATLASLLATSST 428 Query 413 LPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTI 472 LPIMLDSTE V++ GLEHLGGR +NSVN+EDGDGPESR+ + MA+V +HGAAVVALTI Sbjct 429 LPIMLDSTEPEVIRVGLEHLGGRSIVNSVNFEDGDGPESRYRRIMAMVQQHGAAVVALTI 488 Query 473 DEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEA 532 DEEGQARTA+ K+ IAERLI DITG +G+ ES I++D LTF I+TGQEE+RRDGIETIEA Sbjct 489 DEEGQARTAEHKIRIAERLIEDITGTYGLKESDIIVDCLTFPISTGQEETRRDGIETIEA 548 Query 533 IRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNR 592 IRELKKRHP+V TTLGLSNISFGLNPAARQVLNSVFLHEC + GLDSAI H+SKILPMNR Sbjct 549 IRELKKRHPEVHTTLGLSNISFGLNPAARQVLNSVFLHECIQVGLDSAIAHSSKILPMNR 608 Query 593 IPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRI 652 I E QR VALD+VYDRR E YDPLQE M+LFEGVSAA +K+ R LA +PLFERLAQRI Sbjct 609 IDERQREVALDMVYDRRAEGYDPLQEFMQLFEGVSAADAKDARAEALAAMPLFERLAQRI 668 Query 653 VDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAA 712 +DG++NGL+ DL+ M +K P++IINE LL GMKTVGELFGSGQMQLPFVLQSAE MK A Sbjct 669 IDGDKNGLEEDLEAGMKEKKPIEIINEDLLNGMKTVGELFGSGQMQLPFVLQSAETMKTA 728 Query 713 VAYLEPHMERSDDDSG------KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIK 766 VAYLEP ME + +G KGRIVLATVKGDVHDIGKNLVDII+SNNGY+VVN+GIK Sbjct 729 VAYLEPFMEDEAEATGEARAESKGRIVLATVKGDVHDIGKNLVDIIMSNNGYDVVNLGIK 788 Query 767 QPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSY 826 QPI+ +LE AE +AD +GMSGLLVKSTVVMK+NLEEMN A +PV+LGGAALTR+Y Sbjct 789 QPISAMLEAAEKHNADAIGMSGLLVKSTVVMKDNLEEMNA-AKASHYPVMLGGAALTRTY 847 Query 827 VENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQ 886 VENDLAE+YQG+V+YARDAFEGL LMD +M+ +RGE D +SPEAI+A K+ ER+AR++ Sbjct 848 VENDLAEVYQGDVYYARDAFEGLSLMDELMAEQRGEGADPDSPEAIEAARKKEERRARNE 907 Query 887 RSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFL 946 RSKRIAA+RKA EPVEVPERSDVA D V PPFWG+RIVKGLA+A+Y LDERALF+ Sbjct 908 RSKRIAAERKAKAEPVEVPERSDVATDTPVATPPFWGTRIVKGLALAEYLPTLDERALFM 967 Query 947 GQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDI 1006 GQWGL+ RGGEGPSYE+LVETEGRPR RYW+DRL +GIL H A+VYGYFPAVSEG+D+ Sbjct 968 GQWGLKATRGGEGPSYEELVETEGRPRFRYWIDRLKAEGILDHTAIVYGYFPAVSEGDDV 1027 Query 1007 VVLTEPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIA 1066 V+L P+PDAP R RF FPRQQRGRFLCIADFIR RE A G+VDV PFQLVTMG PIA Sbjct 1028 VILESPEPDAPERMRFSFPRQQRGRFLCIADFIRPREQAIAEGQVDVFPFQLVTMGDPIA 1087 Query 1067 DFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDY 1126 FAN+LFA+N YRDYLEVHG+GVQLTEA+AEYWH RIR EL+ + A +D E K+ + Sbjct 1088 QFANKLFAANEYRDYLEVHGLGVQLTEAIAEYWHARIRSELQLTTGGTAADDDAEDKKKF 1147 Query 1127 FKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPE 1186 F L YRGARF+FGYG+CPDLEDR KM+ LL+PERIGV LSEELQLHPEQSTDAFVL+HPE Sbjct 1148 FDLDYRGARFSFGYGSCPDLEDRIKMVELLQPERIGVELSEELQLHPEQSTDAFVLYHPE 1207 Query 1187 AKYFNV 1192 AKYFNV Sbjct 1208 AKYFNV 1213 >gi|134100433|ref|YP_001106094.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|291007313|ref|ZP_06565286.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|133913056|emb|CAM03169.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=1189 Score = 1766 bits (4574), Expect = 0.0, Method: Compositional matrix adjust. Identities = 848/1195 (71%), Positives = 993/1195 (84%), Gaps = 13/1195 (1%) Query 4 ADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETI 63 AD+ + L + +RV+V DG MGT LQA DL+LDDF LEGCNEILNETRPDV+ ++ Sbjct 2 ADRKNDPSGFLAAIGERVLVADGGMGTALQAYDLSLDDFANLEGCNEILNETRPDVVSSV 61 Query 64 HRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYV 123 +R + EAG+DA+ETNTFG NL+NLG+Y I +RIRDL++KGT +AR ADE +PD+ R+V Sbjct 62 YRGFLEAGSDAIETNTFGTNLANLGEYGIPERIRDLAEKGTRLAREAADEYSTPDKPRFV 121 Query 124 LGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRR 183 LGSMGPGTKLPTLGH YA +RDAY E LGM+DGG D +LVET QDLLQ KAA++ ++R Sbjct 122 LGSMGPGTKLPTLGHAPYADLRDAYVENVLGMIDGGIDVVLVETSQDLLQTKAAIVAAKR 181 Query 184 AMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLR 243 AM + GR +P+ A VTVE TGTML+GSEIGAALTA+EPLG+DMIG+NCATGPAEMSEHLR Sbjct 182 AMEQTGRWLPIIAQVTVEQTGTMLVGSEIGAALTALEPLGIDMIGMNCATGPAEMSEHLR 241 Query 244 HLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPA 303 LS+HAR+P+SVMPNAGLP LG GA YPL DELAEALAGF+ FG LVGGCCGTT Sbjct 242 VLSQHARVPISVMPNAGLPELGPNGAVYPLKADELAEALAGFVTNFGARLVGGCCGTTGE 301 Query 304 HIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMI 363 H+R V+ AVA++ PER PSVSS+Y +PF QDAS+L +GERTNANGSK FREAM+ Sbjct 302 HVRAVSEAVASLTPPERTPEVIPSVSSMYQTVPFEQDASILNVGERTNANGSKAFREAML 361 Query 364 AEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETA 423 E Y+ C++IAK QTR+GAH+LDLCVDYVGRDG DM+ LASRLAT+STLPIM+DSTE Sbjct 362 EERYEDCVEIAKAQTREGAHMLDLCVDYVGRDGTKDMRELASRLATASTLPIMVDSTEPD 421 Query 424 VLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQK 483 V+QAGLEHLGGRCA+NSVNYEDG P RF + M +V EHGA VV IDEEGQART Sbjct 422 VIQAGLEHLGGRCAVNSVNYEDGTEPGGRFQRVMEMVREHGATVVVTCIDEEGQARTRDW 481 Query 484 KVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDV 543 K+ +AER+I D+T NWG+++S+I+ID L F I TGQEE R+DGIETIEAIRELKKRHPDV Sbjct 482 KLRVAERMIEDLTTNWGLEKSAIIIDCLVFPITTGQEEVRKDGIETIEAIRELKKRHPDV 541 Query 544 QTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALD 603 QTTLGLSN+SFGLNPAARQVLNSVFL+EC+EAGLDSAIV++SKILPM +I EE R VALD Sbjct 542 QTTLGLSNVSFGLNPAARQVLNSVFLNECREAGLDSAIVNSSKILPMTKIDEEPRKVALD 601 Query 604 LVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDAD 663 LVYDRR E YDPLQ+LM LFEG +A SS R ELA LPLFERL +RIVDGERNGL+AD Sbjct 602 LVYDRRSEGYDPLQKLMELFEGQTAKSSSASRAEELAKLPLFERLEKRIVDGERNGLEAD 661 Query 664 LDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERS 723 L+ AM +KPPL+IIN++LL GMK VG+LFGSGQMQLPFVLQSAEVMKAAVA+LEPHME+ Sbjct 662 LEAAMQEKPPLEIINQNLLGGMKIVGDLFGSGQMQLPFVLQSAEVMKAAVAHLEPHMEK- 720 Query 724 DDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADV 783 DD GKGR++LATVKGDVHDIGKNLVDII+SNNGYEVVNIGIKQPI IL+ AE+ D Sbjct 721 DDSGGKGRLLLATVKGDVHDIGKNLVDIIVSNNGYEVVNIGIKQPINAILDAAEEHKVDA 780 Query 784 VGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYAR 843 +GMSGLLVKSTV+MKENLEEMN+RG+AEK+PV+LGGAALTRSYVENDL E+YQG+V YA+ Sbjct 781 IGMSGLLVKSTVIMKENLEEMNSRGIAEKYPVMLGGAALTRSYVENDLDEVYQGDVRYAK 840 Query 844 DAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVE 903 DAFEGL LMD +M+ KRGE P+E+ EA K+AERKAR +RS RIA +RKAAE + Sbjct 841 DAFEGLHLMDRMMAVKRGETPEEDEAEAA----KKAERKARRERSLRIAEKRKAAEG--D 894 Query 904 VPE------RSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGG 957 +P+ RSDV AD VPAPPFWGS+++KG+ VADY LLDERA F GQWGLRG + G Sbjct 895 IPDLYDESTRSDVDADAPVPAPPFWGSKVIKGVPVADYLALLDERATFFGQWGLRGSKKG 954 Query 958 EGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAP 1017 EGP+YE+LVE+EGRPRLRYW+D L+T GIL HAAVVYGYFP +SEGN ++VL + +PDAP Sbjct 955 EGPTYEELVESEGRPRLRYWIDELATAGILQHAAVVYGYFPVISEGNSLIVLDKEEPDAP 1014 Query 1018 VRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNA 1077 R RF FPRQQR R LC+ADF RSRE A + G+VDVLP QLVTMGQPIAD+ANELFA N+ Sbjct 1015 ERTRFTFPRQQRDRRLCLADFFRSREKAEQTGQVDVLPMQLVTMGQPIADYANELFAKNS 1074 Query 1078 YRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFA 1137 YRDYLE+HG+GVQLTEALAEYWHRRIR EL+FSG + A +DP ++FKLGYRGARF+ Sbjct 1075 YRDYLEIHGMGVQLTEALAEYWHRRIRRELQFSGGASAADQDPADVLEFFKLGYRGARFS 1134 Query 1138 FGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 FGYGACP++EDRAK++ LLE ERIGV LSEE QLHPEQSTDA V HHPEAKYFN Sbjct 1135 FGYGACPEIEDRAKIVELLESERIGVVLSEEFQLHPEQSTDAIVCHHPEAKYFNT 1189 >gi|19552721|ref|NP_600723.1| methionine synthase I cobalamin-binding subunit [Corynebacterium glutamicum ATCC 13032] gi|21324275|dbj|BAB98900.1| Methionine synthase I, cobalamin-binding domain [Corynebacterium glutamicum ATCC 13032] Length=1221 Score = 1764 bits (4570), Expect = 0.0, Method: Compositional matrix adjust. Identities = 856/1218 (71%), Positives = 1005/1218 (83%), Gaps = 28/1218 (2%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDV 59 + A + + ++ LD L+ V++GDGAMGTQLQ DL ++ DF LEGCNEILN+TRPDV Sbjct 6 TSPAHNNAHSSEFLDALANHVLIGDGAMGTQLQGFDLDVEKDFLDLEGCNEILNDTRPDV 65 Query 60 LETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR 119 L IHR YFEAGAD VETNTFGCNL NL DYDIADR R+L+ KGTA+AR VADE+G P R Sbjct 66 LRQIHRAYFEAGADLVETNTFGCNLPNLADYDIADRCRELAYKGTAVAREVADEMG-PGR 124 Query 120 ---KRYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKA 176 +R+V+GS+GPGTKLP+LGH YA +R Y EAALG++DGG DA L+ET QDLLQ+KA Sbjct 125 NGMRRFVVGSLGPGTKLPSLGHAPYADLRGHYKEAALGIIDGGGDAFLIETAQDLLQVKA 184 Query 177 AVLGSRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPA 236 AV G + AM +P+ HVTVETTGTML+GSEIGAALTA++PLG+DMIGLNCATGP Sbjct 185 AVHGVQDAMAELDTFLPIICHVTVETTGTMLMGSEIGAALTALQPLGIDMIGLNCATGPD 244 Query 237 EMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGG 296 EMSEHLR+LS+HA IPVSVMPNAGLPVLG GAEYPL ++LA+ALAGF++E+GLS+VGG Sbjct 245 EMSEHLRYLSKHADIPVSVMPNAGLPVLGKNGAEYPLEAEDLAQALAGFVSEYGLSMVGG 304 Query 297 CCGTTPAHIREVAAAVANIKRPE----------------RQVSYEPSVSSLYTAIPFAQD 340 CCGTTP HIR V AV + E R+V E SV+SLYT++P +Q+ Sbjct 305 CCGTTPEHIRAVRDAVVGVPEQETSTLTKIPAGPVEQASREVEKEDSVASLYTSVPLSQE 364 Query 341 ASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADM 400 + +IGERTN+NGSK FREAM++ D++KC+DIAK QTRDGAH+LDLCVDYVGRDG ADM Sbjct 365 TGISMIGERTNSNGSKAFREAMLSGDWEKCVDIAKQQTRDGAHMLDLCVDYVGRDGTADM 424 Query 401 KALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALV 460 LA+ LATSSTLPIM+DSTE V++ GLEHLGGR +NSVN+EDGDGPESR+ + M LV Sbjct 425 ATLAALLATSSTLPIMIDSTEPEVIRTGLEHLGGRSIVNSVNFEDGDGPESRYQRIMKLV 484 Query 461 AEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQE 520 +HGAAVVALTIDEEGQARTA+ KV IA+RLI+DITG++G+D I++D LTF I+TGQE Sbjct 485 KQHGAAVVALTIDEEGQARTAEHKVRIAKRLIDDITGSYGLDIKDIVVDCLTFPISTGQE 544 Query 521 ESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSA 580 E+RRDGIETIEAIRELKK +P++ TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLDSA Sbjct 545 ETRRDGIETIEAIRELKKLYPEIHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDSA 604 Query 581 IVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELA 640 I H+SKILPMNRI + QR VALD+VYDRR EDYDPLQE M+LFEGVSAA +K+ R +LA Sbjct 605 IAHSSKILPMNRIDDRQREVALDMVYDRRTEDYDPLQEFMQLFEGVSAADAKDARAEQLA 664 Query 641 GLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLP 700 +PLFERLAQRI+DG++NGL+ DL+ M +K P+ IINE LL GMKTVGELFGSGQMQLP Sbjct 665 AMPLFERLAQRIIDGDKNGLEDDLEAGMKEKSPIAIINEDLLNGMKTVGELFGSGQMQLP 724 Query 701 FVLQSAEVMKAAVAYLEPHMER------SDDDSGKGRIVLATVKGDVHDIGKNLVDIILS 754 FVLQSAE MK AVAYLEP ME S GKG+IV+ATVKGDVHDIGKNLVDIILS Sbjct 725 FVLQSAETMKTAVAYLEPFMEEEAEATGSAQAEGKGKIVVATVKGDVHDIGKNLVDIILS 784 Query 755 NNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFP 814 NNGY+VVN+GIKQP++ +LE AE+ ADV+GMSGLLVKSTVVMKENLEEMN G A +P Sbjct 785 NNGYDVVNLGIKQPLSAMLEAAEEHKADVIGMSGLLVKSTVVMKENLEEMNNAG-ASNYP 843 Query 815 VLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKA 874 V+LGGAALTR+YVENDL E+Y GEV+YARDAFEGL+LMD +M+ KRGE D NSPEAI+ Sbjct 844 VILGGAALTRTYVENDLNEVYTGEVYYARDAFEGLRLMDEVMAEKRGEGLDPNSPEAIEQ 903 Query 875 REKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVAD 934 +K+AERKAR++RS++IAA+RKA PV VPERSDV+ D APPFWG+RIVKGL +A+ Sbjct 904 AKKKAERKARNERSRKIAAERKANAAPVIVPERSDVSTDTPTAAPPFWGTRIVKGLPLAE 963 Query 935 YTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVY 994 + G LDERALF+GQWGL+ RG EGPSYEDLVETEGRPRLRYWLDRL ++GIL H A+VY Sbjct 964 FLGNLDERALFMGQWGLKSTRGNEGPSYEDLVETEGRPRLRYWLDRLKSEGILDHVALVY 1023 Query 995 GYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVL 1054 GYFPAV+EG+D+V+L P P A R RF FPRQQRGRFLCIADFIR RE A + G+VDV+ Sbjct 1024 GYFPAVAEGDDVVILESPDPHAAERMRFSFPRQQRGRFLCIADFIRPREQAVKDGQVDVM 1083 Query 1055 PFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRA 1114 PFQLVTMG PIADFANELFA+N YR+YLEVHGIGVQLTEALAEYWH R+R ELK + + Sbjct 1084 PFQLVTMGNPIADFANELFAANEYREYLEVHGIGVQLTEALAEYWHSRVRSELKLNDGGS 1143 Query 1115 MAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPE 1174 +A DPE K +F L YRGARF+FGYG+CPDLEDRAK++ LLEP RIGV LSEELQLHPE Sbjct 1144 VADFDPEDKTKFFDLDYRGARFSFGYGSCPDLEDRAKLVELLEPGRIGVELSEELQLHPE 1203 Query 1175 QSTDAFVLHHPEAKYFNV 1192 QSTDAFVL+HPEAKYFNV Sbjct 1204 QSTDAFVLYHPEAKYFNV 1221 >gi|344045037|gb|EGV40711.1| methionine synthase I cobalamin-binding subunit [Corynebacterium glutamicum S9114] Length=1221 Score = 1762 bits (4564), Expect = 0.0, Method: Compositional matrix adjust. Identities = 855/1218 (71%), Positives = 1005/1218 (83%), Gaps = 28/1218 (2%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDV 59 + A + + ++ LD L+ V++GDGAMGTQLQ DL ++ DF LEGCNEILN+TRPDV Sbjct 6 TSPAHNNAHSSEFLDALANHVLIGDGAMGTQLQGFDLDVEKDFLDLEGCNEILNDTRPDV 65 Query 60 LETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR 119 L IHR YFEAGAD VETNTFGCNL NL DYDIADR R+L+ KGTA+AR VADE+G P R Sbjct 66 LRQIHRAYFEAGADLVETNTFGCNLPNLADYDIADRCRELAYKGTAVAREVADEMG-PGR 124 Query 120 ---KRYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKA 176 +R+V+GS+GPGTKLP+LGH YA +R Y EAALG++DGG DA L+ET QDLLQ+KA Sbjct 125 NGMRRFVVGSLGPGTKLPSLGHAPYADLRGYYKEAALGIIDGGGDAFLIETAQDLLQVKA 184 Query 177 AVLGSRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPA 236 AV G + AM +P+ HVTVETTGTML+GSEIGAALTA++PLG+DMIGLNCATGP Sbjct 185 AVHGVQDAMAELDTFLPIICHVTVETTGTMLMGSEIGAALTALQPLGIDMIGLNCATGPD 244 Query 237 EMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGG 296 EMSEHLR+LS+HA IPVSVMPNAGLPVLG GAEYPL ++LA+ALAGF++E+GLS+VGG Sbjct 245 EMSEHLRYLSKHADIPVSVMPNAGLPVLGKNGAEYPLEAEDLAQALAGFVSEYGLSMVGG 304 Query 297 CCGTTPAHIREVAAAVANIKRPE----------------RQVSYEPSVSSLYTAIPFAQD 340 CCGTTP HIR V AV + E R+V E SV+SLYT++P +Q+ Sbjct 305 CCGTTPEHIRAVRDAVVGVPEQETSTLTKIPAGPVEQASREVEEEDSVASLYTSVPLSQE 364 Query 341 ASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADM 400 + +IGERTN+NGSK FREAM++ D++KC+DIAK QTRDGAH+LDLCVDYVGRDG ADM Sbjct 365 TGISMIGERTNSNGSKAFREAMLSGDWEKCVDIAKQQTRDGAHMLDLCVDYVGRDGTADM 424 Query 401 KALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALV 460 LA+ LATSSTLPIM+DSTE V++ GLEHLGGR +NSVN+EDGDGP+SR+ + M LV Sbjct 425 ATLAALLATSSTLPIMIDSTEPEVIRTGLEHLGGRSIVNSVNFEDGDGPDSRYQRIMKLV 484 Query 461 AEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQE 520 +HGAAVVALTIDEEGQARTA+ KV IA+RLI+DITG++G+D I++D LTF I+TGQE Sbjct 485 KQHGAAVVALTIDEEGQARTAEHKVRIAKRLIDDITGSYGLDIKDIVVDCLTFPISTGQE 544 Query 521 ESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSA 580 E+RRDGIETIEAIRELKK +P++ TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLDSA Sbjct 545 ETRRDGIETIEAIRELKKLYPEIHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDSA 604 Query 581 IVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELA 640 I H+SKILPMNRI + QR VALD+VYDRR EDYDPLQE M+LFEGVSAA +K+ R +LA Sbjct 605 IAHSSKILPMNRIDDRQREVALDMVYDRRTEDYDPLQEFMQLFEGVSAADAKDARAEQLA 664 Query 641 GLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLP 700 +PLFERLAQRI+DG++NGL+ DL+ M +K P+ IINE LL GMKTVGELFGSGQMQLP Sbjct 665 AMPLFERLAQRIIDGDKNGLEDDLEAGMKEKSPIAIINEDLLNGMKTVGELFGSGQMQLP 724 Query 701 FVLQSAEVMKAAVAYLEPHMER------SDDDSGKGRIVLATVKGDVHDIGKNLVDIILS 754 FVLQSAE MK AVAYLEP ME S GKG+IV+ATVKGDVHDIGKNLVDIILS Sbjct 725 FVLQSAETMKTAVAYLEPFMEEEAEATGSAQAEGKGKIVVATVKGDVHDIGKNLVDIILS 784 Query 755 NNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFP 814 NNGY+VVN+GIKQP++ +LE AE+ ADV+GMSGLLVKSTVVMKENLEEMN G A +P Sbjct 785 NNGYDVVNLGIKQPLSAMLEAAEEHKADVIGMSGLLVKSTVVMKENLEEMNNAG-ASNYP 843 Query 815 VLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKA 874 V+LGGAALTR+YVENDL E+Y GEV+YARDAFEGL+LMD +M+ KRGE D NSPEAI+ Sbjct 844 VILGGAALTRTYVENDLNEVYTGEVYYARDAFEGLRLMDEVMAEKRGEGLDPNSPEAIEQ 903 Query 875 REKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVAD 934 +K+AERKAR++RS++IAA+RKA PV VPERSDV+ D APPFWG+RIVKGL +A+ Sbjct 904 AKKKAERKARNERSRKIAAERKANAAPVIVPERSDVSTDTPTAAPPFWGTRIVKGLPLAE 963 Query 935 YTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVY 994 + G LDERALF+GQWGL+ RG EGPSYEDLVETEGRPRLRYWLDRL ++GIL H A+VY Sbjct 964 FLGNLDERALFMGQWGLKSTRGNEGPSYEDLVETEGRPRLRYWLDRLKSEGILDHVALVY 1023 Query 995 GYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVL 1054 GYFPAV+EG+D+V+L P P A R RF FPRQQRGRFLCIADFIR RE A + G+VDV+ Sbjct 1024 GYFPAVAEGDDVVILESPDPHAAERMRFSFPRQQRGRFLCIADFIRPREQAVKDGQVDVM 1083 Query 1055 PFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRA 1114 PFQLVTMG PIADFANELFA+N YR+YLEVHGIGVQLTEALAEYWH R+R ELK + + Sbjct 1084 PFQLVTMGNPIADFANELFAANEYREYLEVHGIGVQLTEALAEYWHSRVRSELKLNDGGS 1143 Query 1115 MAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPE 1174 +A DPE K +F L YRGARF+FGYG+CPDLEDRAK++ LLEP RIGV LSEELQLHPE Sbjct 1144 VADFDPEDKTKFFDLDYRGARFSFGYGSCPDLEDRAKLVELLEPGRIGVELSEELQLHPE 1203 Query 1175 QSTDAFVLHHPEAKYFNV 1192 QSTDAFVL+HPEAKYFNV Sbjct 1204 QSTDAFVLYHPEAKYFNV 1221 >gi|145295640|ref|YP_001138461.1| hypothetical protein cgR_1567 [Corynebacterium glutamicum R] gi|140845560|dbj|BAF54559.1| hypothetical protein [Corynebacterium glutamicum R] Length=1221 Score = 1762 bits (4563), Expect = 0.0, Method: Compositional matrix adjust. Identities = 855/1218 (71%), Positives = 1004/1218 (83%), Gaps = 28/1218 (2%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDV 59 + A + + ++ LD L+ V++GDGAMGTQLQ DL ++ DF LEGCNEILN+TRPDV Sbjct 6 TSPAHNNAHSSEFLDALANHVLIGDGAMGTQLQGFDLDVEKDFLDLEGCNEILNDTRPDV 65 Query 60 LETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR 119 L IHR YFEAGAD VETNTFGCNL NL DYDIADR R+L+ KGTA+AR VADE+G P R Sbjct 66 LRQIHRAYFEAGADLVETNTFGCNLPNLADYDIADRCRELAYKGTAVAREVADEMG-PGR 124 Query 120 ---KRYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKA 176 +R+V+GS+GPGTKLP+LGH YA +R Y EAALG++DGG DA L+ET QDLLQ+KA Sbjct 125 NGMRRFVVGSLGPGTKLPSLGHAPYADLRGHYKEAALGIIDGGGDAFLIETAQDLLQVKA 184 Query 177 AVLGSRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPA 236 AV G + AM +P+ HVTVETTGTML+GSEIGAALTA++PLG+DMIGLNCATGP Sbjct 185 AVHGVQDAMAELDTFLPIICHVTVETTGTMLMGSEIGAALTALQPLGIDMIGLNCATGPD 244 Query 237 EMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGG 296 EMSEHLR+LS+HA IPVSVMPNAGLPVLG GAEYPL ++LA+ALAGF++E+GLS+VGG Sbjct 245 EMSEHLRYLSKHADIPVSVMPNAGLPVLGKNGAEYPLEAEDLAQALAGFVSEYGLSMVGG 304 Query 297 CCGTTPAHIREVAAAVANIKRPE----------------RQVSYEPSVSSLYTAIPFAQD 340 CCGTTP HIR V AV + E R+V E SV+SLYT++P +Q+ Sbjct 305 CCGTTPEHIRAVRDAVVGVPEQETSTLTKIPAGPVEQASREVEEEDSVASLYTSVPLSQE 364 Query 341 ASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADM 400 + +IGERTN+NGSK FREAM++ D++ C+DIAK QTRDGAH+LDLCVDYVGRDG ADM Sbjct 365 TGISMIGERTNSNGSKAFREAMLSGDWETCVDIAKQQTRDGAHMLDLCVDYVGRDGTADM 424 Query 401 KALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALV 460 LA+ LATSSTLPIM+DSTE V++ GLEHLGGR +NSVN+EDGDGP+SR+ + M LV Sbjct 425 ATLAALLATSSTLPIMIDSTEPEVIRTGLEHLGGRSIVNSVNFEDGDGPDSRYQRIMKLV 484 Query 461 AEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQE 520 +HGAAVVALTIDEEGQARTA+ KV IA+RLI+DITG++G+D I++D LTF I+TGQE Sbjct 485 KQHGAAVVALTIDEEGQARTAEHKVRIAKRLIDDITGSYGLDIKDIVVDCLTFPISTGQE 544 Query 521 ESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSA 580 E+RRDGIETIEAIRELKK +P++ TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLDSA Sbjct 545 ETRRDGIETIEAIRELKKLYPEIHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDSA 604 Query 581 IVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELA 640 I H+SKILPMNRI + QR VALD+VYDRR EDYDPLQE M+LFEGVSAA +K+ R +LA Sbjct 605 IAHSSKILPMNRIDDRQREVALDMVYDRRTEDYDPLQEFMQLFEGVSAADAKDARAEQLA 664 Query 641 GLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLP 700 +PLFERLAQRI+DG++NGL+ DL+ M +K P+ IINE LL GMKTVGELFGSGQMQLP Sbjct 665 AMPLFERLAQRIIDGDKNGLEDDLEAGMKEKSPIAIINEDLLNGMKTVGELFGSGQMQLP 724 Query 701 FVLQSAEVMKAAVAYLEPHMER------SDDDSGKGRIVLATVKGDVHDIGKNLVDIILS 754 FVLQSAE MK AVAYLEP ME S GKG+IV+ATVKGDVHDIGKNLVDIILS Sbjct 725 FVLQSAETMKTAVAYLEPFMEEEAEATGSAQAEGKGKIVVATVKGDVHDIGKNLVDIILS 784 Query 755 NNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFP 814 NNGYEVVN+GIKQP++ +LE AE+ ADV+GMSGLLVKSTVVMKENLEEMN G A +P Sbjct 785 NNGYEVVNLGIKQPLSAMLEAAEEHKADVIGMSGLLVKSTVVMKENLEEMNNAG-ASNYP 843 Query 815 VLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKA 874 V+LGGAALTR+YVENDL E+Y GEV+YARDAFEGL+LMD +M+ KRGE D NSPEAI+ Sbjct 844 VILGGAALTRTYVENDLNEVYTGEVYYARDAFEGLRLMDEVMAEKRGEGLDPNSPEAIEQ 903 Query 875 REKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVAD 934 +K+AERKAR++RS++IAA+RKA PV VPERSDV+ D APPFWG+RIVKGL +A+ Sbjct 904 AKKKAERKARNERSRKIAAERKANAAPVIVPERSDVSTDTPTAAPPFWGTRIVKGLPLAE 963 Query 935 YTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVY 994 + G LDERALF+GQWGL+ RG EGPSYEDLVETEGRPRLRYWLDRL ++GIL H A+VY Sbjct 964 FLGNLDERALFMGQWGLKSTRGNEGPSYEDLVETEGRPRLRYWLDRLKSEGILDHVALVY 1023 Query 995 GYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVL 1054 GYFPAV+EG+D+V+L P P A R RF FPRQQRGRFLCIADFIR RE A + G+VDV+ Sbjct 1024 GYFPAVAEGDDVVILESPDPHAAERMRFSFPRQQRGRFLCIADFIRPREQAVKDGQVDVM 1083 Query 1055 PFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRA 1114 PFQLVTMG PIADFANELFA+N YR+YLEVHGIGVQLTEALAEYWH R+R ELK + + Sbjct 1084 PFQLVTMGNPIADFANELFAANEYREYLEVHGIGVQLTEALAEYWHSRVRSELKLNDGGS 1143 Query 1115 MAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPE 1174 +A DPE K +F L YRGARF+FGYG+CPDLEDRAK++ LLEP RIGV LSEELQLHPE Sbjct 1144 VADFDPEDKTKFFDLDYRGARFSFGYGSCPDLEDRAKLVELLEPGRIGVELSEELQLHPE 1203 Query 1175 QSTDAFVLHHPEAKYFNV 1192 QSTDAFVL+HPEAKYFNV Sbjct 1204 QSTDAFVLYHPEAKYFNV 1221 >gi|331697130|ref|YP_004333369.1| methionine synthase [Pseudonocardia dioxanivorans CB1190] gi|326951819|gb|AEA25516.1| methionine synthase [Pseudonocardia dioxanivorans CB1190] Length=1190 Score = 1761 bits (4562), Expect = 0.0, Method: Compositional matrix adjust. Identities = 864/1185 (73%), Positives = 1007/1185 (85%), Gaps = 7/1185 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYF 68 +DT LD L++RV+V DGAMGT LQAADLTLDDF GL+GCNEILN+TRPDV+ IH Y Sbjct 9 HDTSFLDTLARRVVVADGAMGTMLQAADLTLDDFAGLDGCNEILNDTRPDVVRRIHTGYL 68 Query 69 EAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMG 128 EAGADAVETN+FG NL NL +YDIA+RIR+L++KG +AR ADEL +PDR RYVLGS+G Sbjct 69 EAGADAVETNSFGANLPNLAEYDIAERIRELAEKGARLAREAADELSTPDRPRYVLGSVG 128 Query 129 PGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRA 188 PGTKLPTLGH +A +RDAYTE +G+L GGADA ++ETCQDLLQ+KAAVLG RRAM Sbjct 129 PGTKLPTLGHESFARLRDAYTECGIGLLAGGADAFVIETCQDLLQVKAAVLGVRRAMAAE 188 Query 189 GRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRH 248 GR IP+ VTVETTGTMLLGSEIGAALTA+EPLGVD+IGLNCATGPAEMSEHLR LS+H Sbjct 189 GRRIPIITQVTVETTGTMLLGSEIGAALTAIEPLGVDLIGLNCATGPAEMSEHLRTLSKH 248 Query 249 ARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREV 308 ARIP+SVMPNAGLP LG GA YPL PDELAEAL+ F+ ++GL LVGGCCGTTP H+R V Sbjct 249 ARIPLSVMPNAGLPQLGPNGAVYPLSPDELAEALSTFVRDYGLRLVGGCCGTTPDHVRAV 308 Query 309 AAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQ 368 + AVA + R EP VSSLY ++PF QD SVL++GERTNANGSK FREAMI E ++ Sbjct 309 SEAVAAVTPAVRDPRPEPGVSSLYASVPFRQDTSVLMVGERTNANGSKAFREAMIEERWE 368 Query 369 KCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAG 428 C+ IA++QTRDGAH+LDL VDYVGRDGVADM LA RLAT+STLPIM+DSTET V+QAG Sbjct 369 DCVAIAREQTRDGAHMLDLNVDYVGRDGVADMAELAGRLATASTLPIMIDSTETEVVQAG 428 Query 429 LEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIA 488 LEHLGGRC +NSVNYEDGDGP SRF +TMA+V EHGAAVVAL IDEEGQARTA+ KV +A Sbjct 429 LEHLGGRCIVNSVNYEDGDGPGSRFQRTMAVVREHGAAVVALCIDEEGQARTAEWKVRVA 488 Query 489 ERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLG 548 +RLI D+T N G+ I++D LTF I TGQEE RRD +ETIEAIRELK+++P VQTTLG Sbjct 489 DRLIRDLTANHGMRVEDIVVDALTFPITTGQEEVRRDALETIEAIRELKRQYPTVQTTLG 548 Query 549 LSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDR 608 +SN+SFGLN AARQVLNSVFLHEC AGLD+AIVHASKILPM++IP+EQR+VALDLVYDR Sbjct 549 ISNVSFGLNAAARQVLNSVFLHECVTAGLDTAIVHASKILPMSKIPDEQRSVALDLVYDR 608 Query 609 RREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAM 668 RRE YDPL M LFEGV+A+S+K R ELA LPLFERL +RIVDGER GL+ADLD A+ Sbjct 609 RREGYDPLARFMELFEGVTASSAKAGRAEELAALPLFERLERRIVDGERVGLEADLDAAL 668 Query 669 TQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG 728 ++P L+IIN+ LL+GMKTVGELFGSGQMQLPFVLQSAEVMK AVA+LEPHME++ D +G Sbjct 669 EERPALEIINDVLLSGMKTVGELFGSGQMQLPFVLQSAEVMKTAVAHLEPHMEKT-DAAG 727 Query 729 KGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSG 788 KG IVLATVKGDVHDIGKNLVDIILSNNGY VVN+GIKQPI+TIL A++ A VGMSG Sbjct 728 KGTIVLATVKGDVHDIGKNLVDIILSNNGYTVVNLGIKQPISTILSAAQEHGAHAVGMSG 787 Query 789 LLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEG 848 LLVKSTV+MKENLEEMN+RGVAE+ PVLLGGAALTRSYVENDLAE+Y+G V YARDAFEG Sbjct 788 LLVKSTVIMKENLEEMNSRGVAEQLPVLLGGAALTRSYVENDLAELYRGRVSYARDAFEG 847 Query 849 LKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVE--VPE 906 L+LMD M+ RG+AP + E +K AERKARH+RSKRIAA+R+AAE +PE Sbjct 848 LRLMDATMARARGDAPAVDPAE----EQKIAERKARHERSKRIAAKRRAAEAEAAGPLPE 903 Query 907 RSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLV 966 RSDVA D +P PPFWG+R+VKG+AVA+Y+G++DERALFLGQWGLRG +GG GPSYE+LV Sbjct 904 RSDVALDNPLPTPPFWGTRVVKGIAVAEYSGMIDERALFLGQWGLRGAKGGSGPSYEELV 963 Query 967 ETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPR 1026 ETEGRPRLRYWL+RL+T+G+LA+AAVVYGYFPAV+ +++VVLTEP+ DAP R+RF FPR Sbjct 964 ETEGRPRLRYWLERLATEGVLANAAVVYGYFPAVAVRDELVVLTEPRADAPERHRFAFPR 1023 Query 1027 QQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHG 1086 Q+R R LC+ADF R R+LA GE+DVLP LVTMGQPIAD+ANELFA ++YRDYLEVHG Sbjct 1024 QRRDRHLCLADFWRPRDLAIAAGEIDVLPLHLVTMGQPIADYANELFAKDSYRDYLEVHG 1083 Query 1087 IGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDL 1146 +GVQLTEALAEYWHRR+REEL +S R +A +DP+ ED+FKLGYRGAR++ GYGACP+L Sbjct 1084 LGVQLTEALAEYWHRRVREELTWSTGRTLAEDDPDDVEDFFKLGYRGARYSLGYGACPNL 1143 Query 1147 EDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 EDR K++ +LEP RIGV LSEELQLHPEQSTDA V HHPEAKYFN Sbjct 1144 EDRTKIVEMLEPGRIGVGLSEELQLHPEQSTDALVAHHPEAKYFN 1188 >gi|62390389|ref|YP_225791.1| homocysteine methyltransferase [Corynebacterium glutamicum ATCC 13032] gi|41325726|emb|CAF21515.1| Homocysteine Methyltransferase [Corynebacterium glutamicum ATCC 13032] Length=1196 Score = 1752 bits (4537), Expect = 0.0, Method: Compositional matrix adjust. Identities = 851/1198 (72%), Positives = 995/1198 (84%), Gaps = 28/1198 (2%) Query 21 VMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNYFEAGADAVETNT 79 +++GDGAMGTQLQ DL ++ DF LEGCNEILN+TRPDVL IHR YFEAGAD VETNT Sbjct 1 MLIGDGAMGTQLQGFDLDVEKDFLDLEGCNEILNDTRPDVLRQIHRAYFEAGADLVETNT 60 Query 80 FGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVLGSMGPGTKLPTL 136 FGCNL NL DYDIADR R+L+ KGTA+AR VADE+G P R +R+V+GS+GPGTKLP+L Sbjct 61 FGCNLPNLADYDIADRCRELAYKGTAVAREVADEMG-PGRNGMRRFVVGSLGPGTKLPSL 119 Query 137 GHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHIPVFA 196 GH YA +R Y EAALG++DGG DA L+ET QDLLQ+KAAV G + AM +P+ Sbjct 120 GHAPYADLRGHYKEAALGIIDGGGDAFLIETAQDLLQVKAAVHGVQDAMAELDTFLPIIC 179 Query 197 HVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIPVSVM 256 HVTVETTGTML+GSEIGAALTA++PLG+DMIGLNCATGP EMSEHLR+LS+HA IPVSVM Sbjct 180 HVTVETTGTMLMGSEIGAALTALQPLGIDMIGLNCATGPDEMSEHLRYLSKHADIPVSVM 239 Query 257 PNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAVANIK 316 PNAGLPVLG GAEYPL ++LA+ALAGF++E+GLS+VGGCCGTTP HIR V AV + Sbjct 240 PNAGLPVLGKNGAEYPLEAEDLAQALAGFVSEYGLSMVGGCCGTTPEHIRAVRDAVVGVP 299 Query 317 RPE----------------RQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 E R+V E SV+SLYT++P +Q+ + +IGERTN+NGSK FRE Sbjct 300 EQETSTLTKIPAGPVEQASREVEKEDSVASLYTSVPLSQETGISMIGERTNSNGSKAFRE 359 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AM++ D++KC+DIAK QTRDGAH+LDLCVDYVGRDG ADM LA+ LATSSTLPIM+DST Sbjct 360 AMLSGDWEKCVDIAKQQTRDGAHMLDLCVDYVGRDGTADMATLAALLATSSTLPIMIDST 419 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 E V++ GLEHLGGR +NSVN+EDGDGPESR+ + M LV +HGAAVVALTIDEEGQART Sbjct 420 EPEVIRTGLEHLGGRSIVNSVNFEDGDGPESRYQRIMKLVKQHGAAVVALTIDEEGQART 479 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 A+ KV IA+RLI+DITG++G+D I++D LTF I+TGQEE+RRDGIETIEAIRELKK + Sbjct 480 AEHKVRIAKRLIDDITGSYGLDIKDIVVDCLTFPISTGQEETRRDGIETIEAIRELKKLY 539 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 P++ TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLDSAI H+SKILPMNRI + QR V Sbjct 540 PEIHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDSAIAHSSKILPMNRIDDRQREV 599 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALD+VYDRR EDYDPLQE M+LFEGVSAA +K+ R +LA +PLFERLAQRI+DG++NGL Sbjct 600 ALDMVYDRRTEDYDPLQEFMQLFEGVSAADAKDARAEQLAAMPLFERLAQRIIDGDKNGL 659 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 + DL+ M +K P+ IINE LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLEP M Sbjct 660 EDDLEAGMKEKSPIAIINEDLLNGMKTVGELFGSGQMQLPFVLQSAETMKTAVAYLEPFM 719 Query 721 ER------SDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILE 774 E S GKG+IV+ATVKGDVHDIGKNLVDIILSNNGY+VVN+GIKQP++ +LE Sbjct 720 EEEAEATGSAQAEGKGKIVVATVKGDVHDIGKNLVDIILSNNGYDVVNLGIKQPLSAMLE 779 Query 775 VAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEI 834 AE+ ADV+GMSGLLVKSTVVMKENLEEMN G A +PV+LGGAALTR+YVENDL E+ Sbjct 780 AAEEHKADVIGMSGLLVKSTVVMKENLEEMNNAG-ASNYPVILGGAALTRTYVENDLNEV 838 Query 835 YQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQ 894 Y GEV+YARDAFEGL+LMD +M+ KRGE D NSPEAI+ +K+AERKAR++RS++IAA+ Sbjct 839 YTGEVYYARDAFEGLRLMDEVMAEKRGEGLDPNSPEAIEQAKKKAERKARNERSRKIAAE 898 Query 895 RKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQ 954 RKA PV VPERSDV+ D APPFWG+RIVKGL +A++ G LDERALF+GQWGL+ Sbjct 899 RKANAAPVIVPERSDVSTDTPTAAPPFWGTRIVKGLPLAEFLGNLDERALFMGQWGLKST 958 Query 955 RGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKP 1014 RG EGPSYEDLVETEGRPRLRYWLDRL ++GIL H A+VYGYFPAV+EG+D+V+L P P Sbjct 959 RGNEGPSYEDLVETEGRPRLRYWLDRLKSEGILDHVALVYGYFPAVAEGDDVVILESPDP 1018 Query 1015 DAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFA 1074 A R RF FPRQQRGRFLCIADFIR RE A + G+VDV+PFQLVTMG PIADFANELFA Sbjct 1019 HAAERMRFSFPRQQRGRFLCIADFIRPREQAVKDGQVDVMPFQLVTMGNPIADFANELFA 1078 Query 1075 SNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGA 1134 +N YR+YLEVHGIGVQLTEALAEYWH R+R ELK + ++A DPE K +F L YRGA Sbjct 1079 ANEYREYLEVHGIGVQLTEALAEYWHSRVRSELKLNDGGSVADFDPEDKTKFFDLDYRGA 1138 Query 1135 RFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 RF+FGYG+CPDLEDRAK++ LLEP RIGV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1139 RFSFGYGSCPDLEDRAKLVELLEPGRIGVELSEELQLHPEQSTDAFVLYHPEAKYFNV 1196 >gi|257056681|ref|YP_003134513.1| methionine synthase (B12-dependent) [Saccharomonospora viridis DSM 43017] gi|256586553|gb|ACU97686.1| methionine synthase (B12-dependent) [Saccharomonospora viridis DSM 43017] Length=1184 Score = 1738 bits (4500), Expect = 0.0, Method: Compositional matrix adjust. Identities = 841/1186 (71%), Positives = 990/1186 (84%), Gaps = 8/1186 (0%) Query 10 DTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFE 69 D+ L L +RV+V DG MGT LQ DLTLDDF LEGCNE+LN+TRPDV+ ++R++ E Sbjct 4 DSRFLTELDRRVLVADGGMGTALQGFDLTLDDFAQLEGCNEVLNDTRPDVVTAVYRSFLE 63 Query 70 AGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGP 129 AG+DA+ETNTFG N N G+Y I DRIR+L++KGT +AR+ ADE +PDR R+VLGSMGP Sbjct 64 AGSDAIETNTFGTNYGNFGEYGILDRIRELAEKGTVLARQCADEYSTPDRPRFVLGSMGP 123 Query 130 GTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAG 189 GTKLPTLGH YAV+RDAY E ALGMLDGG DA+LVET QDLLQ KAA++G++RAM RAG Sbjct 124 GTKLPTLGHAPYAVLRDAYVENALGMLDGGVDAVLVETSQDLLQAKAAIVGAKRAMARAG 183 Query 190 RHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHA 249 R +P+ A VTVE TGTML+GSEIGAALTA+EPLG+D+IG+NCATGPAEMSEHLR LS HA Sbjct 184 RRVPIIAQVTVEQTGTMLVGSEIGAALTALEPLGIDLIGMNCATGPAEMSEHLRVLSEHA 243 Query 250 RIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVA 309 R+P+SVMPNAGLP LG GA YPL PDELAEALA F+ EFG+ LVGGCCGTTP H+R V Sbjct 244 RVPISVMPNAGLPELGPDGAVYPLRPDELAEALATFVTEFGVRLVGGCCGTTPEHVRAVV 303 Query 310 AAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQK 369 AV++++ ER+ + P+VSS+Y ++PF QDAS+L +GERTNANGSK FR+AM+ Y Sbjct 304 EAVSSLRPKERRPEHTPAVSSVYQSVPFKQDASILNVGERTNANGSKAFRQAMLEGRYDD 363 Query 370 CLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGL 429 C++IAK QTR+GAH+LDLCVDYVGRDG DM LASRLAT+STLPIM+DSTE V++ GL Sbjct 364 CVEIAKAQTREGAHVLDLCVDYVGRDGTTDMAELASRLATASTLPIMVDSTEPEVVRTGL 423 Query 430 EHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAE 489 EH GGRCAINSVNYEDG GP+SR+ + + L EHGAAVV IDEEGQARTA+ K+ +AE Sbjct 424 EHFGGRCAINSVNYEDGTGPDSRYRRVLELAVEHGAAVVVTCIDEEGQARTAEWKLRVAE 483 Query 490 RLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGL 549 R I+D+T NWG+D+SSI+ID L F I TGQEE R+D +ETI AIR+LK+RHPDV TTLGL Sbjct 484 RAISDLTTNWGLDKSSIIIDCLVFPITTGQEEVRKDALETINAIRQLKRRHPDVMTTLGL 543 Query 550 SNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRR 609 SN+SFGLNPAARQVLNSVFLHEC+EAGLDSAI+++SKILPMN+I +E R VALDLVYDRR Sbjct 544 SNVSFGLNPAARQVLNSVFLHECREAGLDSAILNSSKILPMNKIEDEPRQVALDLVYDRR 603 Query 610 REDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMT 669 R+ YDPLQ LM+LFEG +A+S++ R ELA LPLFERL +RIV+GE GL+ DLD AM Sbjct 604 RDGYDPLQRLMQLFEGKTASSARASRAEELAKLPLFERLEKRIVEGETTGLEEDLDAAMR 663 Query 670 QKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGK 729 +K P+ IINEHLLAGMK VG+LFGSGQMQLPFVLQSAE MKAAVAYLEPHME++D D GK Sbjct 664 EKKPIDIINEHLLAGMKVVGDLFGSGQMQLPFVLQSAETMKAAVAYLEPHMEKTDAD-GK 722 Query 730 GRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGL 789 G+++LATVKGDVHDIGKNLVDII+SNNGY+VVNIGIKQPI ILE AE+ D +GMSGL Sbjct 723 GKLLLATVKGDVHDIGKNLVDIIVSNNGYDVVNIGIKQPINAILEAAEEHQVDAIGMSGL 782 Query 790 LVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGL 849 LVKSTVVMKENL+EMN RGVA K+PVLLGGAALTR+YVENDL EIY+G+V YA+DAFEGL Sbjct 783 LVKSTVVMKENLQEMNARGVATKYPVLLGGAALTRTYVENDLDEIYEGDVRYAKDAFEGL 842 Query 850 KLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEP---VEVPE 906 KLMD IM+ KRGE P+E++ E K+AERKAR +RS RIA +R+A + P + Sbjct 843 KLMDRIMAVKRGETPEEDAAE----EAKKAERKARRERSLRIAEKRRAEQGPEPDLYDTT 898 Query 907 RSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLV 966 RSDV D+ VP PPFWG+++VKG+AVADY LLDERA F GQWGLRG R GEGPSYE+LV Sbjct 899 RSDVDPDVPVPVPPFWGAKVVKGVAVADYLSLLDERATFFGQWGLRGARKGEGPSYEELV 958 Query 967 ETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPR 1026 E+EGRPRLR W+D LST GILAHAA+VYGYFP SEGND+VVL + +PDA R RF FPR Sbjct 959 ESEGRPRLRAWIDELSTQGILAHAALVYGYFPCYSEGNDLVVLEKDEPDALERLRFTFPR 1018 Query 1027 QQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHG 1086 Q+R R LC+ADF RS+E A + G+VDVLP QLVTMGQPIAD+ANELFA NAYRDYLEVHG Sbjct 1019 QRRDRRLCLADFFRSKEKAEQTGQVDVLPMQLVTMGQPIADYANELFARNAYRDYLEVHG 1078 Query 1087 IGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDL 1146 +GVQLTEALAEYWHRRIR+EL+F +AAEDPE + +F+LGYRGARF+FGYGACPDL Sbjct 1079 LGVQLTEALAEYWHRRIRQELRFPSGAPVAAEDPEDVQQFFRLGYRGARFSFGYGACPDL 1138 Query 1147 EDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 EDRAK++ LL+ RIGVTLSEE QLHPEQSTDA V HHPEAKYFN Sbjct 1139 EDRAKIVELLDAGRIGVTLSEEFQLHPEQSTDAIVAHHPEAKYFNT 1184 >gi|300786796|ref|YP_003767087.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Amycolatopsis mediterranei U32] gi|299796310|gb|ADJ46685.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Amycolatopsis mediterranei U32] Length=1184 Score = 1707 bits (4422), Expect = 0.0, Method: Compositional matrix adjust. Identities = 860/1185 (73%), Positives = 996/1185 (85%), Gaps = 14/1185 (1%) Query 13 LLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGA 72 L+ L RV+V DGAMGT LQA DL+L DF GLEGCNEILN TRPDV+ ++HR Y EAGA Sbjct 9 FLEALRSRVLVADGAMGTALQAHDLSLADFDGLEGCNEILNVTRPDVVRSVHRGYLEAGA 68 Query 73 DAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTK 132 DAVETNTFG N +N +YDI RI +L++ G +AR ADE +PDR R+VLGS+GPGTK Sbjct 69 DAVETNTFGANFANFAEYDITGRIFELAEAGARLARETADEFATPDRPRFVLGSVGPGTK 128 Query 133 LPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHI 192 LPTLGH + +RDAY E G+L GGADA++VET QD+LQ KA+++G++RAM GR + Sbjct 129 LPTLGHAPFTTLRDAYQEEVRGLLAGGADAVIVETTQDILQTKASIIGAKRAMAAEGRFV 188 Query 193 PVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIP 252 P+ A +TVETTGTMLLG+E+GAAL A+EPLG+D+IGLNCATGPAEMSEHLR L++HAR+P Sbjct 189 PILASITVETTGTMLLGTEVGAALAALEPLGIDVIGLNCATGPAEMSEHLRQLAKHARVP 248 Query 253 VSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAV 312 +SVMPNAGLP LG GA YPL P+ L EAL GF+ EFG+ LVGGCCGTT HIR++AAAV Sbjct 249 LSVMPNAGLPELGPDGAVYPLGPEALVEALTGFVREFGVGLVGGCCGTTDEHIRQLAAAV 308 Query 313 ANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLD 372 A+ R+ EP VSSLY A+PF QDASVL+IGERTNANGSK FR AM+ + C++ Sbjct 309 ADTPPVPRRPRPEPGVSSLYQAVPFKQDASVLMIGERTNANGSKAFRTAMLEGRWDDCVE 368 Query 373 IAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHL 432 IA++QTRDGAHLLDLCVDYVGRDG ADM LA RLAT+STLPIMLDSTE VL+A L+ L Sbjct 369 IAREQTRDGAHLLDLCVDYVGRDGTADMAELAGRLATASTLPIMLDSTEVPVLRAALQRL 428 Query 433 GGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLI 492 GGRCA+NSVNYEDGDGPESRFA+ M LV+E+GAAVVALTIDEEGQARTAQKK +IA RLI Sbjct 429 GGRCAVNSVNYEDGDGPESRFAQVMELVSEYGAAVVALTIDEEGQARTAQKKADIATRLI 488 Query 493 NDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNI 552 DITGNWG+ S ++ID LTFTIATGQEESRRDGIETIEAIRE+K+RHP+VQTTLGLSNI Sbjct 489 EDITGNWGLRTSDVIIDALTFTIATGQEESRRDGIETIEAIREIKRRHPEVQTTLGLSNI 548 Query 553 SFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRRED 612 SFGLNPAARQVLNSVFLHEC +AGLD+AIVHASKILPM RIP++QR +ALDL++DRRRE Sbjct 549 SFGLNPAARQVLNSVFLHECVQAGLDTAIVHASKILPMARIPDDQRAIALDLIHDRRREG 608 Query 613 YDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKP 672 YDPLQELM LFEGVSAASSK R ELA LPLFERL +RIVDGER GL DLD A+ Q+P Sbjct 609 YDPLQELMALFEGVSAASSKASRAEELAALPLFERLERRIVDGERTGLTDDLDAALEQRP 668 Query 673 PLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGRI 732 L+IIN+ LL+GMKTVGELFGSGQMQLPFVLQSAEVMKAAVA+LEPHME + DDSGKGRI Sbjct 669 ALEIINDTLLSGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAHLEPHME-TGDDSGKGRI 727 Query 733 VLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVK 792 VLATV+GDVHDIGKNLVDIILSNNGYEVVN+GIKQPI TIL+ AE+ AD +GMSGLLVK Sbjct 728 VLATVRGDVHDIGKNLVDIILSNNGYEVVNLGIKQPITTILDAAEEHGADAIGMSGLLVK 787 Query 793 STVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLM 852 STV+MKENL+EMN+RGV ++PVLLGGAALTRSYVENDL+E+Y G+V YARDAFEGL+LM Sbjct 788 STVIMKENLQEMNSRGVWARWPVLLGGAALTRSYVENDLSELYLGDVRYARDAFEGLRLM 847 Query 853 DTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIA---AQRKAAEEPVE--VPER 907 D +M+AKRGE+ ++ A +K ERK R +RS RIA RKA EE +E P R Sbjct 848 DALMAAKRGESTLVDA----DAEKKRQERKERRERSLRIAEARKARKADEEALEGPPPAR 903 Query 908 SDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVE 967 SDVA D+ +P PPFWGSR+VKG+A+ADY +LDERA F+GQWGL+G RGG GP+Y++LVE Sbjct 904 SDVATDVPLPVPPFWGSRVVKGIALADYAAMLDERATFMGQWGLKGARGGAGPTYDELVE 963 Query 968 TEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQ 1027 +EGRPRLRYWLDRL+ DG+LAHAAVVYGYFP V+EG+D+VVLTEP DAP R RF FPRQ Sbjct 964 SEGRPRLRYWLDRLTADGVLAHAAVVYGYFPCVAEGDDLVVLTEPSLDAPERVRFTFPRQ 1023 Query 1028 QRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGI 1087 +R R LC+ADF R RE GEVDV+PF +VTMGQPIAD+ANELFA++AYRDYLEVHG+ Sbjct 1024 RRDRRLCLADFYRPREA----GEVDVVPFTVVTMGQPIADYANELFAADAYRDYLEVHGL 1079 Query 1088 GVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLE 1147 GVQLTEALAEYWH RIR EL F G A+A+EDP+ ED+FKLGYRGARF+ GYGACPDLE Sbjct 1080 GVQLTEALAEYWHCRIRGELTFPGGVAVASEDPDDVEDFFKLGYRGARFSLGYGACPDLE 1139 Query 1148 DRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 DRAK++ALLEP RIGV LSEE QLHPEQSTDA V HHPEAKYFN Sbjct 1140 DRAKIVALLEPGRIGVKLSEEYQLHPEQSTDAIVCHHPEAKYFNT 1184 >gi|302206179|gb|ADL10521.1| Methionine synthase [Corynebacterium pseudotuberculosis C231] gi|341824861|gb|AEK92382.1| Methionine synthase [Corynebacterium pseudotuberculosis PAT10] Length=1199 Score = 1704 bits (4413), Expect = 0.0, Method: Compositional matrix adjust. Identities = 822/1194 (69%), Positives = 972/1194 (82%), Gaps = 12/1194 (1%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 + TD LD + RV++GDGAMGTQLQA DL +D DF GLEGCNEILN TRPDV+ IHR+Y Sbjct 8 FQTDFLDAMKDRVLIGDGAMGTQLQAFDLDVDKDFLGLEGCNEILNITRPDVVAQIHRSY 67 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVL 124 FEAGAD VETNTFGCNL NL DY IA+R R+L+ +G IAR VADELG P R +R+VL Sbjct 68 FEAGADLVETNTFGCNLPNLADYGIAERCRELAYQGVHIARTVADELG-PGRDGLRRFVL 126 Query 125 GSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRA 184 GSMGPGTKLP+LGH + +R+ Y+EAA+GM++GGADAIL+ET QDLLQ+KAA+ G + A Sbjct 127 GSMGPGTKLPSLGHASFEELREYYSEAAVGMIEGGADAILIETAQDLLQVKAAIHGCQHA 186 Query 185 MTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRH 244 G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLR Sbjct 187 FEIVGIKLPLVCHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRF 246 Query 245 LSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAH 304 LS++A IPVSVMPNAGLPVLG GAEYPL ELA AL GF+ ++GLS+VGGCCGTTP+H Sbjct 247 LSQNAGIPVSVMPNAGLPVLGKNGAEYPLSAHELAAALRGFVNDYGLSMVGGCCGTTPSH 306 Query 305 IREVAAAVANIK------RPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGF 358 I V A+ + R + +VSSLYT++ QD + +IGERTNANGSK F Sbjct 307 ISAVRDAIVGTSNATAAHQARRSPTVGDAVSSLYTSVNLTQDTGITMIGERTNANGSKAF 366 Query 359 REAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLD 418 REAM+AED++ C+DIAK QTRDGAH+LDLCVDYVGRDG DM LAS L+TSSTLPIM+D Sbjct 367 REAMLAEDWETCIDIAKQQTRDGAHMLDLCVDYVGRDGRQDMAQLASLLSTSSTLPIMID 426 Query 419 STETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQA 478 STE V+Q GLEHLGGRCA+NSVN+EDGDGP+SR+ + M LV +HGAAVVALTIDE+GQA Sbjct 427 STEPDVIQVGLEHLGGRCAVNSVNFEDGDGPKSRYQRIMRLVKQHGAAVVALTIDEDGQA 486 Query 479 RTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKK 538 RTA KK+ IAERLI DIT WG++E I++D LTF I+TGQEE+RRDGIETIE IRELKK Sbjct 487 RTAAKKIAIAERLITDITQTWGLEEDDIIVDCLTFPISTGQEETRRDGIETIEVIRELKK 546 Query 539 RHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQR 598 R+P + TTLGLSNISFGLNPAARQVLNSVFL+EC AGLDSAI H+SKILPMN+I EEQR Sbjct 547 RYPRIHTTLGLSNISFGLNPAARQVLNSVFLNECIGAGLDSAIAHSSKILPMNKIDEEQR 606 Query 599 NVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERN 658 VALD+VYD+R DYDPLQ MRLFEGVSA+++K+ R LA +PLFER+AQR++DGE+ Sbjct 607 RVALDMVYDKRTADYDPLQAFMRLFEGVSASTAKDARAEALAAMPLFERIAQRVIDGEKT 666 Query 659 GLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEP 718 G++ADLD+AM +K PLQIINE LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLE Sbjct 667 GIEADLDQAMAEKEPLQIINEDLLEGMKTVGELFGSGQMQLPFVLQSAETMKHAVAYLEQ 726 Query 719 HMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAED 778 ME DD G G IV+ATVKGDVHDIGKNLVDIILSNNG+ VVNIGIKQPI+ IL+ A+ Sbjct 727 FMEAEDDTGGNGTIVIATVKGDVHDIGKNLVDIILSNNGFNVVNIGIKQPISNILDAAKK 786 Query 779 KSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGE 838 +AD +GMSGLLVKSTV+MKENL+EMN A FPV+LGGAALTR+YVE+DL E+Y G Sbjct 787 HNADAIGMSGLLVKSTVIMKENLQEMNAVK-ASHFPVILGGAALTRAYVEDDLTEVYDGN 845 Query 839 VHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAA 898 V+YA+DAFE L+LM M++ RGE D NSP+AIKA +K+AERKAR +RSK+IAA+RKA Sbjct 846 VYYAKDAFESLRLMQEFMASIRGEGLDPNSPDAIKAAQKKAERKARKERSKKIAAERKAK 905 Query 899 EEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGE 958 EPV VP RS V+ + PPFWG+RIVKGL +++Y LLDERALF+G+WGL+ RG Sbjct 906 AEPVAVPARSQVSETSPITTPPFWGTRIVKGLNLSEYLPLLDERALFMGRWGLKATRGAA 965 Query 959 GPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPV 1018 GPSYE+LVETEGRPRLRYW+DRL + +L HAAV+YGYFPAVSEGND+++L P P+A Sbjct 966 GPSYEELVETEGRPRLRYWIDRLKAEKVLDHAAVIYGYFPAVSEGNDVILLESPDPEATE 1025 Query 1019 RYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAY 1078 RF FPRQQR +FLCIADFI+SR + E+G VDV P QLVTMGQPIADFANELFA++ Y Sbjct 1026 IARFTFPRQQRSKFLCIADFIQSRTRSLEQGSVDVFPLQLVTMGQPIADFANELFAADNY 1085 Query 1079 RDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAF 1138 RDYLEVHGIGVQLTEA+AEYWH R+R EL F + +D + + +F L Y GAR++F Sbjct 1086 RDYLEVHGIGVQLTEAMAEYWHARVRGELTFIDGSSAGDKDAKNLQRFFDLDYLGARYSF 1145 Query 1139 GYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GYG+CP+LEDR ++ LL+ +RIGV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1146 GYGSCPNLEDRKTLVQLLDAQRIGVELSEELQLHPEQSTDAFVLYHPEAKYFNV 1199 >gi|300858469|ref|YP_003783452.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium pseudotuberculosis FRC41] gi|300685923|gb|ADK28845.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium pseudotuberculosis FRC41] gi|302330738|gb|ADL20932.1| Methionine synthase [Corynebacterium pseudotuberculosis 1002] gi|308276421|gb|ADO26320.1| 5-methyl tetrahydrofolate--homocysteine methyltransferase [Corynebacterium pseudotuberculosis I19] Length=1199 Score = 1704 bits (4412), Expect = 0.0, Method: Compositional matrix adjust. Identities = 822/1194 (69%), Positives = 972/1194 (82%), Gaps = 12/1194 (1%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 + TD LD + RV++GDGAMGTQLQA DL +D DF GLEGCNEILN TRPDV+ IHR+Y Sbjct 8 FQTDFLDAMKDRVLIGDGAMGTQLQAFDLDVDKDFLGLEGCNEILNITRPDVVAQIHRSY 67 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVL 124 FEAGAD VETNTFGCNL NL DY IA+R R+L+ +G IAR VADELG P R +R+VL Sbjct 68 FEAGADLVETNTFGCNLPNLADYGIAERCRELAYQGVHIARTVADELG-PGRDGLRRFVL 126 Query 125 GSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRA 184 GSMGPGTKLP+LGH + +R+ Y+EAA+GM++GGADAIL+ET QDLLQ+KAA+ G + A Sbjct 127 GSMGPGTKLPSLGHASFEELREYYSEAAVGMIEGGADAILIETAQDLLQVKAAIHGCQHA 186 Query 185 MTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRH 244 G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLR Sbjct 187 FEIVGIKLPLVCHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRF 246 Query 245 LSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAH 304 LS++A IPVSVMPNAGLPVLG GAEYPL ELA AL GF+ ++GLS+VGGCCGTTP+H Sbjct 247 LSQNAGIPVSVMPNAGLPVLGKNGAEYPLSAHELAAALRGFVNDYGLSMVGGCCGTTPSH 306 Query 305 IREVAAAVANIK------RPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGF 358 I V A+ + R + +VSSLYT++ QD + +IGERTNANGSK F Sbjct 307 ISAVRDAIVGTSNATAAHQARRSPTVGDAVSSLYTSVNLTQDTGITMIGERTNANGSKAF 366 Query 359 REAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLD 418 REAM+AED++ C+DIAK QTRDGAH+LDLCVDYVGRDG DM LAS L+TSSTLPIM+D Sbjct 367 REAMLAEDWETCIDIAKQQTRDGAHMLDLCVDYVGRDGRQDMAQLASLLSTSSTLPIMID 426 Query 419 STETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQA 478 STE V+Q GLEHLGGRCA+NSVN+EDGDGP+SR+ + M LV +HGAAVVALTIDE+GQA Sbjct 427 STEPDVIQVGLEHLGGRCAVNSVNFEDGDGPKSRYQRIMRLVKQHGAAVVALTIDEDGQA 486 Query 479 RTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKK 538 RTA KK+ IAERLI DIT WG++E I++D LTF I+TGQEE+RRDGIETIE IRELKK Sbjct 487 RTAAKKIAIAERLITDITQTWGLEEDDIIVDCLTFPISTGQEETRRDGIETIEVIRELKK 546 Query 539 RHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQR 598 R+P + TTLGLSNISFGLNPAARQVLNSVFL+EC AGLDSAI H+SKILPMN+I EEQR Sbjct 547 RYPRIHTTLGLSNISFGLNPAARQVLNSVFLNECIGAGLDSAIAHSSKILPMNKIDEEQR 606 Query 599 NVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERN 658 VALD+VYD+R DYDPLQ MRLFEGVSA+++K+ R LA +PLFER+AQR++DGE+ Sbjct 607 RVALDMVYDKRTADYDPLQAFMRLFEGVSASTAKDARAEALAAMPLFERIAQRVIDGEKT 666 Query 659 GLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEP 718 G++ADLD+AM +K PLQIINE LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLE Sbjct 667 GIEADLDQAMAEKEPLQIINEDLLEGMKTVGELFGSGQMQLPFVLQSAETMKHAVAYLEQ 726 Query 719 HMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAED 778 ME DD G G IV+ATVKGDVHDIGKNLVDIILSNNG+ VVNIGIKQPI+ IL+ A+ Sbjct 727 FMEAEDDTGGNGTIVIATVKGDVHDIGKNLVDIILSNNGFNVVNIGIKQPISNILDAAKK 786 Query 779 KSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGE 838 +AD +GMSGLLVKSTV+MKENL+EMN A FPV+LGGAALTR+YVE+DL E+Y G Sbjct 787 HNADAIGMSGLLVKSTVIMKENLQEMNAVK-ASHFPVILGGAALTRAYVEDDLTEVYDGN 845 Query 839 VHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAA 898 V+YA+DAFE L+LM M++ RGE D NSP+AIKA +K+AERKAR +RSK+IAA+RKA Sbjct 846 VYYAKDAFESLRLMQEFMASIRGEGLDPNSPDAIKAAQKKAERKARKERSKKIAAERKAK 905 Query 899 EEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGE 958 EPV VP RS V+ + PPFWG+RIVKGL +++Y LLDERALF+G+WGL+ RG Sbjct 906 AEPVAVPARSQVSETSPIATPPFWGTRIVKGLNLSEYLPLLDERALFMGRWGLKATRGAA 965 Query 959 GPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPV 1018 GPSYE+LVETEGRPRLRYW+DRL + +L HAAV+YGYFPAVSEGND+++L P P+A Sbjct 966 GPSYEELVETEGRPRLRYWIDRLKAEKVLDHAAVIYGYFPAVSEGNDVILLESPDPEATE 1025 Query 1019 RYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAY 1078 RF FPRQQR +FLCIADFI+SR + E+G VDV P QLVTMGQPIADFANELFA++ Y Sbjct 1026 IARFTFPRQQRSKFLCIADFIQSRTRSLEQGSVDVFPLQLVTMGQPIADFANELFAADNY 1085 Query 1079 RDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAF 1138 RDYLEVHGIGVQLTEA+AEYWH R+R EL F + +D + + +F L Y GAR++F Sbjct 1086 RDYLEVHGIGVQLTEAMAEYWHARVRGELTFIDGSSAGDKDAKNLQRFFDLDYLGARYSF 1145 Query 1139 GYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GYG+CP+LEDR ++ LL+ +RIGV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1146 GYGSCPNLEDRKTLVQLLDAQRIGVELSEELQLHPEQSTDAFVLYHPEAKYFNV 1199 >gi|334696843|gb|AEG81640.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium ulcerans 809] Length=1199 Score = 1701 bits (4405), Expect = 0.0, Method: Compositional matrix adjust. Identities = 823/1194 (69%), Positives = 971/1194 (82%), Gaps = 12/1194 (1%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 + TD LD + RV++GDGAMGTQLQA DL +D DF GLEGCNEILN TRPDV+ IHR+Y Sbjct 8 FRTDFLDAMKDRVLIGDGAMGTQLQAFDLDVDKDFLGLEGCNEILNVTRPDVVARIHRSY 67 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVL 124 FEAGAD VETNTFGCNL NL DY IA+R R+L+ +G IAR VADELG P R +R++L Sbjct 68 FEAGADLVETNTFGCNLPNLADYGIAERCRELAYEGVRIARAVADELG-PGRDGLRRFIL 126 Query 125 GSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRA 184 GSMGPGTKLP+LGH + +R+ YTEAA GM++GGADAILVET QDLLQ+KAA+ G ++A Sbjct 127 GSMGPGTKLPSLGHAPFGELREYYTEAATGMIEGGADAILVETAQDLLQVKAAIHGCQQA 186 Query 185 MTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRH 244 + G IP+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLR Sbjct 187 FEKIGIQIPIVCHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRF 246 Query 245 LSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAH 304 LSR+A IP+SVMPNAGLPVLG GAEYPL ELA AL GF+ ++GLS+VGGCCGTTP+H Sbjct 247 LSRNASIPISVMPNAGLPVLGKNGAEYPLSARELAAALKGFVNDYGLSMVGGCCGTTPSH 306 Query 305 I---REVAAAVANI---KRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGF 358 I R+ AN+ ++ +R +VSSLYT++ QD + +IGERTNANGSK F Sbjct 307 ISAVRDAIVGTANVPAAQQAQRNPVVGDAVSSLYTSVNLTQDTGITMIGERTNANGSKAF 366 Query 359 REAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLD 418 REAM+A D++ C+DIAK QTRDGAH+LDLCVDYVGRDG DM LAS L+TSSTLPIM+D Sbjct 367 REAMLAADWETCVDIAKQQTRDGAHMLDLCVDYVGRDGRQDMAQLASLLSTSSTLPIMID 426 Query 419 STETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQA 478 STE V+Q GLEHLGGRCA+NSVN+EDGDGP+SR+ + M LV +HGAAVVALTIDEEGQA Sbjct 427 STEPGVIQVGLEHLGGRCAVNSVNFEDGDGPDSRYQRIMRLVKQHGAAVVALTIDEEGQA 486 Query 479 RTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKK 538 RTA +KV IA+RLI DIT WG+ E I++D LTF I+TGQEE+RRDGIETIEAIRELKK Sbjct 487 RTAAQKVAIADRLITDITQTWGLKEDDIIVDCLTFPISTGQEETRRDGIETIEAIRELKK 546 Query 539 RHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQR 598 R+P + TTLGLSNISFGLNPAARQVLNSVFL+EC GLDSAI H+SKILPMN+I EEQR Sbjct 547 RYPRIHTTLGLSNISFGLNPAARQVLNSVFLNECIGVGLDSAIAHSSKILPMNKIDEEQR 606 Query 599 NVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERN 658 VALD+VYDRR DYDPLQ M+LFEGVSA+S+K+ R LA +PLFER+AQR++DGE+ Sbjct 607 RVALDMVYDRRTADYDPLQTFMQLFEGVSASSAKDARAEALAAMPLFERIAQRVIDGEKT 666 Query 659 GLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEP 718 G++ADLD+AM +K PL+IINE LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLE Sbjct 667 GIEADLDQAMAEKEPLRIINEDLLEGMKTVGELFGSGQMQLPFVLQSAETMKHAVAYLEQ 726 Query 719 HMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAED 778 ME DD G G IV+ATVKGDVHDIGKNLVDIILSNNG+ V+NIGIKQPI+ IL+ A++ Sbjct 727 FMEAEDDTGGNGTIVIATVKGDVHDIGKNLVDIILSNNGFNVINIGIKQPISNILDAAKE 786 Query 779 KSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGE 838 +AD +GMSGLLVKSTV+MKENL+EMN A FPV+LGGAALTR+YVE+DL E+Y G Sbjct 787 HNADAIGMSGLLVKSTVIMKENLQEMNA-AEASHFPVILGGAALTRAYVEDDLTEVYNGN 845 Query 839 VHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAA 898 V+YA+DAFE L+LM M+ RGE D NSP+AIKA +K+AERKAR +RSK IAA+RKA Sbjct 846 VYYAKDAFESLRLMQEFMARIRGEGLDPNSPDAIKAAQKKAERKARKERSKNIAAERKAK 905 Query 899 EEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGE 958 EPV VP RS V+ + PPFWG+RIVKGL +++Y LLDERALF+G+WGL+ RG Sbjct 906 AEPVVVPTRSQVSESSPLATPPFWGTRIVKGLNLSEYLPLLDERALFMGRWGLKATRGAA 965 Query 959 GPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPV 1018 GPSYE+LVETEGRPRLRYW+DRL + IL HAAV+YGYFPAVSEG+D+ +L P P A Sbjct 966 GPSYEELVETEGRPRLRYWIDRLKAEKILDHAAVIYGYFPAVSEGDDVTLLESPDPSAAE 1025 Query 1019 RYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAY 1078 RF FPRQQR +FLCIADFI+SR E+G VDVLP QLVTMGQPIADFANELFA++ Y Sbjct 1026 IARFTFPRQQRSKFLCIADFIQSRTRCLEQGTVDVLPLQLVTMGQPIADFANELFAADNY 1085 Query 1079 RDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAF 1138 RDYLEVHG+GVQLTEA+AEYWH R+R EL S + +D + + +F L Y GAR++F Sbjct 1086 RDYLEVHGVGVQLTEAMAEYWHARVRSELTLSDGSSAGDKDAKNLQRFFDLDYLGARYSF 1145 Query 1139 GYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GYG+CP+LEDR ++ LL+ +RIGV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1146 GYGSCPNLEDRKTLVELLDAQRIGVELSEELQLHPEQSTDAFVLYHPEAKYFNV 1199 >gi|305681089|ref|ZP_07403896.1| methionine synthase [Corynebacterium matruchotii ATCC 14266] gi|305659294|gb|EFM48794.1| methionine synthase [Corynebacterium matruchotii ATCC 14266] Length=1189 Score = 1697 bits (4396), Expect = 0.0, Method: Compositional matrix adjust. Identities = 832/1186 (71%), Positives = 960/1186 (81%), Gaps = 12/1186 (1%) Query 12 DLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNYFEA 70 D LD L RV++GDGAMGTQLQ DL ++ DF GLEGCNEILN+TRPDV+ IHR YF A Sbjct 11 DFLDALHSRVLIGDGAMGTQLQGFDLDVETDFLGLEGCNEILNDTRPDVVAQIHRAYFTA 70 Query 71 GADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVLGSM 127 GAD VETNTFGCNL NL DY+IADR ++L+ KGT IAR VADELG P R +R+VLGSM Sbjct 71 GADLVETNTFGCNLPNLADYNIADRCQELAYKGTRIARTVADELG-PGRDGMRRFVLGSM 129 Query 128 GPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTR 187 GPGTKLP+LGH Y ++ Y EAALGM+DGGAD IL+ET QDLLQ+KAA+ G + A Sbjct 130 GPGTKLPSLGHAPYLDLKTYYREAALGMVDGGADGILIETAQDLLQVKAAIHGCQEAFAE 189 Query 188 AGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSR 247 G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLR+LSR Sbjct 190 VGYRLPIVCHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRYLSR 249 Query 248 HARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIRE 307 +ARIPVSVMPNAGLP+LG GAEYPL P ELA +L FI E+GL++VGGCCGTTP HI Sbjct 250 NARIPVSVMPNAGLPILGKNGAEYPLKPAELAASLKTFIEEYGLAMVGGCCGTTPEHITA 309 Query 308 VAAAVAN-IKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAED 366 V V I ER +VSSLYT++ QDA V +IGERTNANGSK FREAM+A D Sbjct 310 VHTMVTGGITPAERTTPDSDAVSSLYTSVNLTQDAGVTIIGERTNANGSKAFREAMLAGD 369 Query 367 YQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQ 426 + C+DIAK QTRDGAH+LDLCVDYVGRDG DM ALAS LATSSTLPIM+DSTE V+Q Sbjct 370 LETCVDIAKQQTRDGAHMLDLCVDYVGRDGRDDMAALASLLATSSTLPIMIDSTEPNVIQ 429 Query 427 AGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVE 486 GLEHLGGRCA+NSVN+EDGDGP SR+ + M LV HGAAVVALTIDEEGQARTA+KK+ Sbjct 430 TGLEHLGGRCAVNSVNFEDGDGPGSRYQRIMQLVKTHGAAVVALTIDEEGQARTAEKKLA 489 Query 487 IAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTT 546 IAERLI DIT NWG+DES I++DTLTF I+TGQEE+RRDGIETI AIRELK RHP V TT Sbjct 490 IAERLITDITENWGLDESDIIVDTLTFPISTGQEETRRDGIETINAIRELKARHPRVHTT 549 Query 547 LGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVY 606 LGLSNISFGLNPAARQVLNSVFL+EC AGLDSAI H+SK++PMNRI + QR VALD++Y Sbjct 550 LGLSNISFGLNPAARQVLNSVFLNECVAAGLDSAIAHSSKLVPMNRIEDRQREVALDMIY 609 Query 607 DRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDE 666 DRRR+ YDPLQ M LFEGVSAA +K+ R LA LPLFERL+QRI+DGE+ G++ DLD Sbjct 610 DRRRDGYDPLQTFMDLFEGVSAAEAKDARAEALAALPLFERLSQRIIDGEKTGIETDLDA 669 Query 667 AMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDD 726 AM +K P+ IIN+ LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLE +ME +DD Sbjct 670 AMAEKSPINIINQDLLGGMKTVGELFGSGQMQLPFVLQSAETMKHAVAYLENYMEATDDS 729 Query 727 SGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGM 786 KG +V+ATVKGDVHDIGKNLVDIILSNNGY V+NIGIKQPIATI+ A + +ADVVGM Sbjct 730 GNKGTMVIATVKGDVHDIGKNLVDIILSNNGYNVINIGIKQPIATIISAAREHNADVVGM 789 Query 787 SGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAF 846 SGLLVKSTVVMKENLEEMN + A PV+LGGAALTRSYVE+DL IY G+VHYARDAF Sbjct 790 SGLLVKSTVVMKENLEEMNAQN-ASDIPVILGGAALTRSYVEHDLDNIYAGDVHYARDAF 848 Query 847 EGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPE 906 EGL LMD IM+ KRGE E+ + + K+AERKAR +RS++IAA+RKA +PV++PE Sbjct 849 EGLSLMDEIMARKRGETITED----VTKQRKKAERKARRERSQKIAAERKAKAKPVQLPE 904 Query 907 RSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLV 966 RS+VAAD V PPFWG+RI+KGL+V+DY +LDERALF+GQWGL+ R G+GP YE LV Sbjct 905 RSEVAADFPVATPPFWGTRIIKGLSVSDYLLMLDERALFMGQWGLKSTR-GDGPDYEALV 963 Query 967 ETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPR 1026 E+EGRPRLR W+D+L + G+L HAAVVYGYFPAVS + +++L EP+PDA V FPR Sbjct 964 ESEGRPRLRAWIDQLKSRGVLDHAAVVYGYFPAVSVKDMVLILAEPRPDAEVIRELKFPR 1023 Query 1027 QQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHG 1086 QQRG+FLCIAD++RSR LA E G+VDVLP QLVTMG PIA +ANELFA N YRDYLEVHG Sbjct 1024 QQRGKFLCIADYVRSRTLAEETGQVDVLPLQLVTMGDPIARYANELFAMNNYRDYLEVHG 1083 Query 1087 IGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDL 1146 IGVQLTEALAEYWH RIR EL+ + D +F L Y GAR++FGYG+CP+L Sbjct 1084 IGVQLTEALAEYWHSRIRAELRLPDGTHVGDSDAHDTRRFFDLDYSGARYSFGYGSCPNL 1143 Query 1147 EDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 DR ++ LL ERIGVTLSEE QLHPEQSTDAFVL+HPEAKYFNV Sbjct 1144 TDRQAIVDLLHSERIGVTLSEEYQLHPEQSTDAFVLYHPEAKYFNV 1189 >gi|225021445|ref|ZP_03710637.1| hypothetical protein CORMATOL_01465 [Corynebacterium matruchotii ATCC 33806] gi|224945827|gb|EEG27036.1| hypothetical protein CORMATOL_01465 [Corynebacterium matruchotii ATCC 33806] Length=1189 Score = 1693 bits (4385), Expect = 0.0, Method: Compositional matrix adjust. Identities = 830/1186 (70%), Positives = 959/1186 (81%), Gaps = 12/1186 (1%) Query 12 DLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNYFEA 70 D LD L RV++GDGAMGTQLQ DL ++ DF GLEGCNEILN+TRPDV+ IHR YF A Sbjct 11 DFLDALHSRVLIGDGAMGTQLQGFDLDVETDFLGLEGCNEILNDTRPDVVAQIHRAYFTA 70 Query 71 GADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVLGSM 127 GAD VETNTFGCNL NL DY+IADR ++L+ KGT IAR VADELG P R +R+VLGSM Sbjct 71 GADLVETNTFGCNLPNLADYNIADRCQELAYKGTRIARTVADELG-PGRDGMRRFVLGSM 129 Query 128 GPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTR 187 GPGTKLP+LGH Y ++ Y EAALGM+DGGAD IL+ET QDLLQ+KAA+ G + A Sbjct 130 GPGTKLPSLGHAPYLDLKTYYREAALGMVDGGADGILIETAQDLLQVKAAIHGCQEAFAE 189 Query 188 AGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSR 247 G +P+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLR+LS Sbjct 190 VGYRLPIVCHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRYLSH 249 Query 248 HARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIRE 307 +A+IPVSVMPNAGLP+LG GAEYPL P ELA +L FI E+GL++VGGCCGTTP HI Sbjct 250 NAQIPVSVMPNAGLPILGKNGAEYPLKPAELAASLKTFIEEYGLAMVGGCCGTTPEHITA 309 Query 308 VAAAV-ANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAED 366 V V I ER +VSSLYT++ QDA V +IGERTNANGSK FREAM+A D Sbjct 310 VHTMVTGGITPAERATPDSDAVSSLYTSVNLTQDAGVTIIGERTNANGSKAFREAMLAGD 369 Query 367 YQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQ 426 + C+DIAK QTRDGAH+LDLCVDYVGRDG DM ALAS LATSSTLPIM+DSTE V+Q Sbjct 370 LETCVDIAKQQTRDGAHMLDLCVDYVGRDGRGDMAALASLLATSSTLPIMIDSTEPDVIQ 429 Query 427 AGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVE 486 GLEHLGGRCA+NSVN+EDGDGP SR+ + M LV HGAAVVALTIDEEGQARTA+KK+ Sbjct 430 TGLEHLGGRCAVNSVNFEDGDGPGSRYQRIMQLVKTHGAAVVALTIDEEGQARTAEKKLA 489 Query 487 IAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTT 546 IAERLI DIT NWG+DES I++DTLTF I+TGQEE+RRDGIETI AIRELK RHP V TT Sbjct 490 IAERLITDITENWGLDESDIIVDTLTFPISTGQEETRRDGIETINAIRELKARHPRVHTT 549 Query 547 LGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVY 606 LGLSNISFGLNPAARQVLNSVFL+EC AGLDSAI H+SK++PMNRI + QR VALD++Y Sbjct 550 LGLSNISFGLNPAARQVLNSVFLNECVAAGLDSAIAHSSKLVPMNRIEDRQREVALDMIY 609 Query 607 DRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDE 666 DRRR+ YDPLQ M LFEGVSAA +K+ R LA LPLFERL+QRI+DGE+ G++ DLD Sbjct 610 DRRRDGYDPLQTFMDLFEGVSAAEAKDARAEALAALPLFERLSQRIIDGEKTGIETDLDA 669 Query 667 AMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDD 726 AM +K P+ IIN+ LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLE +ME +DD Sbjct 670 AMAEKSPIDIINQDLLGGMKTVGELFGSGQMQLPFVLQSAETMKHAVAYLENYMEATDDS 729 Query 727 SGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGM 786 KG +V+ATVKGDVHDIGKNLVDIILSNNGY V+NIGIKQPIATI+ A + +ADVVGM Sbjct 730 GNKGTMVIATVKGDVHDIGKNLVDIILSNNGYNVINIGIKQPIATIISAAREHNADVVGM 789 Query 787 SGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAF 846 SGLLVKSTVVMKENLEEMN + A PV+LGGAALTRSYVE+DL IY G+VHYARDAF Sbjct 790 SGLLVKSTVVMKENLEEMNAQN-ASDIPVILGGAALTRSYVEHDLDNIYAGDVHYARDAF 848 Query 847 EGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPE 906 EGL LMD IM+ KRGE E+ + + K+AERKAR +RS++IAA+RKA +PV++PE Sbjct 849 EGLSLMDEIMARKRGETITED----VTKQRKKAERKARRERSQKIAAERKAKAKPVQLPE 904 Query 907 RSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLV 966 RS+VAAD V PPFWG+RI+KGL+V+DY +LDERALF+GQWGL+ R G+GP YE LV Sbjct 905 RSEVAADFPVATPPFWGTRIIKGLSVSDYLPMLDERALFMGQWGLKSTR-GDGPDYEALV 963 Query 967 ETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPR 1026 E+EGRPRLR W+D+L + G+L HAAVVYGYFPAVS + +++L EP+PDA V FPR Sbjct 964 ESEGRPRLRAWIDQLKSRGVLDHAAVVYGYFPAVSVKDTVLILAEPRPDAEVIRELKFPR 1023 Query 1027 QQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHG 1086 QQRG+FLCIAD++RSR LA E G+VDVLP QLVTMG PIA +ANELFA N YRDYLEVHG Sbjct 1024 QQRGKFLCIADYVRSRTLAEETGQVDVLPLQLVTMGDPIARYANELFAMNNYRDYLEVHG 1083 Query 1087 IGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDL 1146 IGVQLTEALAEYWH RIR EL+ + D +F L Y GAR++FGYG+CP+L Sbjct 1084 IGVQLTEALAEYWHSRIRAELRLPDGTHVGDSDAHDTRRFFDLDYSGARYSFGYGSCPNL 1143 Query 1147 EDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 DR ++ LL ERIGVTLSEE QLHPEQSTDAFVL+HPEAKYFNV Sbjct 1144 TDRQAIVDLLHSERIGVTLSEEYQLHPEQSTDAFVLYHPEAKYFNV 1189 >gi|337290730|ref|YP_004629751.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium ulcerans BR-AD22] gi|334699036|gb|AEG83832.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium ulcerans BR-AD22] Length=1199 Score = 1693 bits (4384), Expect = 0.0, Method: Compositional matrix adjust. Identities = 819/1194 (69%), Positives = 967/1194 (81%), Gaps = 12/1194 (1%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 + TD LD + RV++GDGAMGTQLQA DL +D DF GLEGCNEILN TRPDV+ IHR+Y Sbjct 8 FRTDFLDAMKDRVLIGDGAMGTQLQAFDLDVDKDFLGLEGCNEILNVTRPDVVARIHRSY 67 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVL 124 FEAGAD VETNTFGCNL NL DY I++R R+L+ +G IAR VADELG P R +R+VL Sbjct 68 FEAGADLVETNTFGCNLPNLADYGISERCRELAYEGVRIARAVADELG-PGRDGLRRFVL 126 Query 125 GSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRA 184 GSMGPGTKLP+LGH + +R+ Y EAA GM++GGADAILVET QDLLQ+KAA+ G ++A Sbjct 127 GSMGPGTKLPSLGHAPFEELREYYAEAATGMIEGGADAILVETAQDLLQVKAAIHGCQQA 186 Query 185 MTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRH 244 + G IP+ HVTVETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGP EMSEHLR Sbjct 187 FEKIGIQIPIVCHVTVETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPDEMSEHLRF 246 Query 245 LSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAH 304 LSR+A IPVSVMPNAGLPVLG GAEYPL ELA AL F+ ++GLS+VGGCCGTTP+H Sbjct 247 LSRNAGIPVSVMPNAGLPVLGKNGAEYPLSARELAAALKSFVNDYGLSMVGGCCGTTPSH 306 Query 305 IREVAAAVANI------KRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGF 358 I V A+ ++ +R + +VSSLYT++ Q+ + +IGERTNANGSK F Sbjct 307 ISAVRDAIVGTVDVPAAQQAQRNPAAGDAVSSLYTSVNLTQETGITMIGERTNANGSKAF 366 Query 359 REAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLD 418 REAM+A D++ C+DIAK QTRDGAH+LDLCVDYVGRDG DM LAS L+TSSTLPIM+D Sbjct 367 REAMLAADWETCVDIAKQQTRDGAHMLDLCVDYVGRDGRQDMAQLASLLSTSSTLPIMID 426 Query 419 STETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQA 478 STE +V+Q GLEHLGGRCA+NSVN+EDGDGP+SR+ + M LV +HGAAVVALTIDEEGQA Sbjct 427 STEPSVIQVGLEHLGGRCAVNSVNFEDGDGPDSRYQRIMRLVKQHGAAVVALTIDEEGQA 486 Query 479 RTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKK 538 RTA +KV IAERLI DIT WG+ E I++D LTF I+TGQEE+RRDGIETIEAIRELKK Sbjct 487 RTAAQKVAIAERLITDITQTWGLKEDDIIVDCLTFPISTGQEETRRDGIETIEAIRELKK 546 Query 539 RHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQR 598 R+P + TTLGLSNISFGLNPAARQVLNSVFL+EC GLDSAI H+SKILPMN+I EEQR Sbjct 547 RYPRIHTTLGLSNISFGLNPAARQVLNSVFLNECIGVGLDSAIAHSSKILPMNKIDEEQR 606 Query 599 NVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERN 658 VALD+VYDRR DYDPLQ M+LFEGVSA+S+K+ R LA +PLFER+AQR++DGE+ Sbjct 607 RVALDMVYDRRTADYDPLQTFMQLFEGVSASSAKDARAEALAAMPLFERIAQRVIDGEKT 666 Query 659 GLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEP 718 G++ DLD+AM +K PL+IINE LL GMKTVGELFGSGQMQLPFVLQSAE MK AVAYLE Sbjct 667 GIETDLDQAMAEKEPLRIINEDLLEGMKTVGELFGSGQMQLPFVLQSAETMKHAVAYLEQ 726 Query 719 HMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAED 778 ME DD G G IV+ATVKGDVHDIGKNLVDIILSNNG+ V+NIGIKQPI+ IL+ A+ Sbjct 727 FMEAEDDTGGNGTIVIATVKGDVHDIGKNLVDIILSNNGFNVINIGIKQPISNILDAAKK 786 Query 779 KSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGE 838 +AD +GMSGLLVKSTV+MKENL+EMN A FPV+LGGAALTR+YVE+DL E+Y G Sbjct 787 HNADAIGMSGLLVKSTVIMKENLQEMNA-AEASHFPVILGGAALTRAYVEDDLTEVYNGN 845 Query 839 VHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAA 898 V+YA+DAFE L+LM M+ RGE D NSP+AIKA +K+AERKAR +RSK IAA+RKA Sbjct 846 VYYAKDAFESLRLMQEFMARIRGEGLDPNSPDAIKAAQKKAERKARKERSKNIAAERKAK 905 Query 899 EEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGE 958 EPV VP RS V+ + PPFWG+RIVKGL +++Y LLDERALF+G+WGL+ RG Sbjct 906 AEPVVVPTRSQVSETSPLATPPFWGTRIVKGLNLSEYLPLLDERALFMGRWGLKATRGAA 965 Query 959 GPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPV 1018 GPSYE+LVETEGRPRLRYW+DRL + IL HAAV+YGYFPAVSEG+D+++L P P A Sbjct 966 GPSYEELVETEGRPRLRYWIDRLKAEKILDHAAVIYGYFPAVSEGDDVILLESPDPSAAE 1025 Query 1019 RYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAY 1078 RF FPRQQR +FLCIADFI+SR E+G VDV P QLVTMGQPIADFANELFA++ Y Sbjct 1026 IARFTFPRQQRSKFLCIADFIQSRTRCLEQGTVDVFPLQLVTMGQPIADFANELFAADNY 1085 Query 1079 RDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAF 1138 RDYLEVHG+GVQLTEA+AEYWH R+R EL S + +D + + +F L Y GAR++F Sbjct 1086 RDYLEVHGVGVQLTEAMAEYWHARVRSELTLSDGSSAGDKDAKNLQRFFDLDYLGARYSF 1145 Query 1139 GYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GYG+CP+LEDR ++ LL+ +RIGV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1146 GYGSCPNLEDRKTLVELLDTQRIGVELSEELQLHPEQSTDAFVLYHPEAKYFNV 1199 >gi|38233847|ref|NP_939614.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Corynebacterium diphtheriae NCTC 13129] gi|38200108|emb|CAE49788.1| 5-methyltetrahydrofolate--homocysteine methyltransferase [Corynebacterium diphtheriae] Length=1201 Score = 1692 bits (4382), Expect = 0.0, Method: Compositional matrix adjust. Identities = 846/1194 (71%), Positives = 971/1194 (82%), Gaps = 11/1194 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 + T LD + RV++GDGAMGTQLQ DL +D DF GLEGCNEILN TRPDV+ IHR Y Sbjct 9 FKTAFLDAMKNRVLIGDGAMGTQLQGFDLDVDSDFLGLEGCNEILNHTRPDVVSAIHRAY 68 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELG-SPD-RKRYVLG 125 FEAGAD VETNTFGCNL NL DYDIADR ++L+ KG IAR VADELG S D R+VLG Sbjct 69 FEAGADLVETNTFGCNLPNLADYDIADRCKELAFKGVKIAREVADELGPSADGTPRFVLG 128 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 SMGPGTKLP+LGH Y +++ YTEA+LGM++GGADAILVET QDLLQ+KAAV G + A Sbjct 129 SMGPGTKLPSLGHAPYEALKNHYTEASLGMIEGGADAILVETAQDLLQVKAAVHGCQTAF 188 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 +G +P+ HVTVETTGTMLLGSEIGAALTA+EPL VDMIGLNCATGP EMSEHLR+L Sbjct 189 ETSGIQLPIVCHVTVETTGTMLLGSEIGAALTAIEPLNVDMIGLNCATGPDEMSEHLRYL 248 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 SR+A IPVSVMPNAGLPVLG GAEYPL ELA AL GF+ E+GLS+VGGCCGTTP HI Sbjct 249 SRNAHIPVSVMPNAGLPVLGKNGAEYPLTEQELASALRGFVEEYGLSMVGGCCGTTPTHI 308 Query 306 REVAAAVA--NIKRPERQVSYEP----SVSSLYTAIPFAQDASVLVIGERTNANGSKGFR 359 REV AV + +P Q P +VSSLYT++ QD + +IGERTNANGSK FR Sbjct 309 REVRKAVLGDSEHQPALQAERNPDVGDAVSSLYTSVNLTQDTGITMIGERTNANGSKAFR 368 Query 360 EAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDS 419 EAM+ D +KC+DIAK QTRDGAH+LDLCVDYVGRDG ADM LAS LATSSTLPIM+DS Sbjct 369 EAMLVGDLEKCVDIAKQQTRDGAHMLDLCVDYVGRDGTADMAQLASLLATSSTLPIMIDS 428 Query 420 TETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQAR 479 TE V+Q GLEHLGGRCA+NSVN+EDGDGP+SR+ + M LV HGAAVVALTIDEEGQAR Sbjct 429 TEPDVIQVGLEHLGGRCAVNSVNFEDGDGPDSRYQRIMRLVKRHGAAVVALTIDEEGQAR 488 Query 480 TAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKR 539 TA+KK+EIAERLI DIT WG+DES I++DTLTF I+TGQEE+RRDGIETIEAIRELKKR Sbjct 489 TAEKKIEIAERLIADITSTWGLDESDIIVDTLTFPISTGQEETRRDGIETIEAIRELKKR 548 Query 540 HPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRN 599 HP + TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLDSAI H+SKI+PMNRI EEQR Sbjct 549 HPKIHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDSAIAHSSKIVPMNRIDEEQRR 608 Query 600 VALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNG 659 VALDLVYDRR E YDPLQ MRLFEGVSAAS+ + R LA +PLF+R+AQRI+DGE+ G Sbjct 609 VALDLVYDRRSEGYDPLQTFMRLFEGVSAASASDARAEALAAMPLFKRIAQRIIDGEKAG 668 Query 660 LDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPH 719 + DLD M +K PLQIINE LL GMKTVG+LFGSGQMQLPFVLQSAE MK AVAYLE Sbjct 669 FEDDLDAGMKEKEPLQIINEDLLEGMKTVGDLFGSGQMQLPFVLQSAETMKHAVAYLEQF 728 Query 720 MERSDD-DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAED 778 +E +D G G IV+ATVKGDVHDIGKNLVDIILSNNG+ VVNIGIKQPIA ILE AE Sbjct 729 IEADEDAGDGNGTIVIATVKGDVHDIGKNLVDIILSNNGFNVVNIGIKQPIANILEAAEK 788 Query 779 KSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGE 838 AD +GMSGLLVKSTV+MKENL+EMN + +PV+LGGAALTR+YVE+DL E+Y+G Sbjct 789 HKADAIGMSGLLVKSTVIMKENLQEMN-QAQKSDYPVILGGAALTRAYVEDDLTEVYEGN 847 Query 839 VHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAA 898 VHYA+DAFE L+LM M+ RGE D SPEA+ A +K+AERKAR +RSK+I AQRKA Sbjct 848 VHYAKDAFESLRLMQEFMAEARGERLDPQSPEALAAAKKKAERKARRERSKQIVAQRKAK 907 Query 899 EEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGE 958 E P+EVPERS+VAAD+ + PPFWG+RIVKG+ +++Y LLDERALF+G+WGL+ RGGE Sbjct 908 EIPIEVPERSEVAADVPIATPPFWGTRIVKGINLSEYLPLLDERALFVGRWGLKATRGGE 967 Query 959 GPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPV 1018 GPSYE+LVETEGRPRLRYW+DRL + IL HAAVVYGYFPAVSEG+ +++L P P + Sbjct 968 GPSYEELVETEGRPRLRYWIDRLKAEKILDHAAVVYGYFPAVSEGDTVILLESPDPTSAE 1027 Query 1019 RYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAY 1078 RF+FPRQQRG+FLC+ADFIRSRE A + VDV P QLVTMGQPIADFAN LFA N Y Sbjct 1028 VARFNFPRQQRGKFLCVADFIRSREHAIKTKTVDVFPLQLVTMGQPIADFANVLFADNNY 1087 Query 1079 RDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAF 1138 RDYLEVHGIGVQLTEALAEYWH RIR EL S ED +++F L YRGAR++F Sbjct 1088 RDYLEVHGIGVQLTEALAEYWHARIRHELSLSDGSHAGDEDSADLQEFFNLKYRGARYSF 1147 Query 1139 GYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 GYG+CP+LEDR ++ LL+ RIGV +SEE QLHPEQSTDAFVL+HPEAKYFNV Sbjct 1148 GYGSCPNLEDRETLVDLLDSRRIGVDISEEFQLHPEQSTDAFVLYHPEAKYFNV 1201 >gi|319949268|ref|ZP_08023348.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Dietzia cinnamea P4] gi|319437058|gb|EFV92098.1| putative 5-methyltetrahydrofolate:homocysteine S-methyltransferase [Dietzia cinnamea P4] Length=1186 Score = 1690 bits (4376), Expect = 0.0, Method: Compositional matrix adjust. Identities = 844/1187 (72%), Positives = 977/1187 (83%), Gaps = 8/1187 (0%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 +D+ LLD +RV++GDGAMGT LQA DL +D DF GLEGCNEILN TRPDV+E IHR + Sbjct 5 FDSPLLDAARRRVLIGDGAMGTMLQAVDLDVDEDFLGLEGCNEILNATRPDVVEGIHRAF 64 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPD--RKRYVLG 125 FEAGAD VETNTFGCNLSNLGDYDI DRI +L++KG AIARRVADE+G + R VLG Sbjct 65 FEAGADLVETNTFGCNLSNLGDYDIVDRIGELAEKGAAIARRVADEIGPSEDGTPRMVLG 124 Query 126 SMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAM 185 S+GPGTKLP+LG T + IRDAY++AA G+ GGADA L+ET QDLLQ+KAAVLG + M Sbjct 125 SLGPGTKLPSLGQTTFEDIRDAYSKAAEGLARGGADAYLIETSQDLLQVKAAVLGCQDGM 184 Query 186 TRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHL 245 AGR +P+ +HVT+ETTGTMLLGS+IGAALTA++PLG+DMIGLNCATGPAEM EHLR+L Sbjct 185 AAAGRRLPIISHVTIETTGTMLLGSDIGAALTALQPLGIDMIGLNCATGPAEMVEHLRYL 244 Query 246 SRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHI 305 SRHA IPVSVMPNAGLP LG GA YPL +E +A F++EFGLS+VGGCCGTTP HI Sbjct 245 SRHAEIPVSVMPNAGLPELGEHGAVYPLGAEEFGPQVADFVSEFGLSMVGGCCGTTPEHI 304 Query 306 REVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAE 365 + V+ R ER V +V+SLY++ P DA +++IGERTNANGSK FREAM+A Sbjct 305 TRLKEQVSARTRAERTVEPVNAVASLYSSTPLRADAGIIMIGERTNANGSKRFREAMLAS 364 Query 366 DYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVL 425 D+ C+DIAK+Q RDGA ++DLCVDYVGRDG DM LA R+ATSSTLPIMLDSTE V+ Sbjct 365 DWDTCMDIAKEQMRDGAQMVDLCVDYVGRDGSGDMAELAGRMATSSTLPIMLDSTEPEVI 424 Query 426 QAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKV 485 +AGLE LGGRCA+NSVNYEDG GP+SRF + M LV+ HGAAVV LTIDEEGQARTA +KV Sbjct 425 RAGLEKLGGRCAVNSVNYEDGAGPDSRFQRIMRLVSRHGAAVVGLTIDEEGQARTADRKV 484 Query 486 EIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQT 545 EIAERLI D+TGNWG+ E I+ID LTF I+TGQEE RRDGIETIEAIR L + HP + T Sbjct 485 EIAERLIADLTGNWGMAEEDIIIDCLTFPISTGQEEVRRDGIETIEAIRRLTEAHPRIHT 544 Query 546 TLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLV 605 TLGLSNISFGLNPAARQVLNSVFLHEC +AGLDSAI H+SKILPM++I + QR VALDLV Sbjct 545 TLGLSNISFGLNPAARQVLNSVFLHECVQAGLDSAIAHSSKILPMSKIDDRQREVALDLV 604 Query 606 YDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLD 665 YDRRRE YDPLQ M LFEGVSAA +K R AELA +PL ERLA RIVDGER GL+ DLD Sbjct 605 YDRRREGYDPLQVFMELFEGVSAAGAKNARAAELAAMPLMERLAARIVDGERKGLEEDLD 664 Query 666 EAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDD 725 AM + PPL+IINEHLL GMKTVGELFGSGQMQLPFVLQSAE MKAAVA+LEPHME SD+ Sbjct 665 AAMVEIPPLEIINEHLLGGMKTVGELFGSGQMQLPFVLQSAETMKAAVAHLEPHMEASDE 724 Query 726 DSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVG 785 D GKGRIVLATVKGDVHDIGKNLVDIILSNNGY+VVNIGIKQPI+ I+ A + ADV+G Sbjct 725 D-GKGRIVLATVKGDVHDIGKNLVDIILSNNGYDVVNIGIKQPISEIISAAREHKADVIG 783 Query 786 MSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDA 845 MSGLLVKSTVVMK+NL E+N+ G+A +FPVLLGGAALTRSYVE DLAE+YQG+V YARDA Sbjct 784 MSGLLVKSTVVMKDNLAELNSEGIAGEFPVLLGGAALTRSYVEVDLAEMYQGDVFYARDA 843 Query 846 FEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVP 905 FEGL+LMD +M+AKR P ++ +A K AER+ R RS+RIAA+R A EPV +P Sbjct 844 FEGLRLMDEVMTAKRTGVP---MAQSSEAAAKAAERRERRARSERIAAKRAAEAEPVVIP 900 Query 906 ERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDL 965 ERSDVAAD + PPFWG+RI KG+ VADY G LDERAL+ GQWGLRG R GEGP Y++L Sbjct 901 ERSDVAADQPIATPPFWGTRIAKGIPVADYLGHLDERALYFGQWGLRGTRSGEGPDYDEL 960 Query 966 VETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFP 1025 VETEGRPR+R W+DRL+T+GIL+H+AVVYGYFPA S G++I VL EP+PDA V ++ FP Sbjct 961 VETEGRPRMRAWIDRLTTEGILSHSAVVYGYFPAYSVGDEIWVLAEPRPDAEVLHKIAFP 1020 Query 1026 RQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVH 1085 RQQR RFL I DF+ SRE G VDVLPFQLVTMG PIADFANELFA + YRDYLEVH Sbjct 1021 RQQRSRFLAIPDFVASRERCEAEGTVDVLPFQLVTMGSPIADFANELFAGDNYRDYLEVH 1080 Query 1086 GIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPD 1145 G+ VQLTEALAE+WHRR+R+EL D +++ EDP++ +DYF L YRGAR++FGYGACPD Sbjct 1081 GLSVQLTEALAEFWHRRVRDELTLP-DGSVSDEDPDSIQDYFNLKYRGARYSFGYGACPD 1139 Query 1146 LEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LE R ++ LLEPERIGV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1140 LESRKVVVDLLEPERIGVVLSEELQLHPEQSTDAFVLYHPEAKYFNV 1186 >gi|258652965|ref|YP_003202121.1| methionine synthase [Nakamurella multipartita DSM 44233] gi|258556190|gb|ACV79132.1| methionine synthase [Nakamurella multipartita DSM 44233] Length=1195 Score = 1674 bits (4336), Expect = 0.0, Method: Compositional matrix adjust. Identities = 846/1193 (71%), Positives = 977/1193 (82%), Gaps = 13/1193 (1%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 VTAA +H LL LS+RV+V DGAMGT LQA D +LDDF GLEGCNEILN TRPD++ Sbjct 10 VTAAPRH----PLLTALSERVLVADGAMGTMLQAQDPSLDDFAGLEGCNEILNVTRPDIV 65 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 +HR Y E G DA+ETNTFG NL+NL +YDI DRI +LS+ G A+AR ADE +PD Sbjct 66 RAVHRAYLEVGVDAIETNTFGANLANLAEYDIPDRIYELSRAGAALARAEADEFSTPDHP 125 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 R+VLGS+GPGTKLPTLGH Y +RDAY + G+LDGG+DAI+VETCQDLLQ K+A+L Sbjct 126 RFVLGSVGPGTKLPTLGHAGYVTLRDAYQQEVAGLLDGGSDAIIVETCQDLLQAKSAILA 185 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 ++RAMT +G +P+ HVTVETTGTMLLGSEIGAALTA+EPLGVD IGLNCATGPAEMSE Sbjct 186 AKRAMTASGIVVPIIVHVTVETTGTMLLGSEIGAALTALEPLGVDYIGLNCATGPAEMSE 245 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLR+LSRHA + VSVMPNAGLP LG GA YPL P ELA+AL+GF+ EFGL LVGGCCGT Sbjct 246 HLRYLSRHATVGVSVMPNAGLPQLGPNGAVYPLSPAELAQALSGFVTEFGLGLVGGCCGT 305 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TP H+R+V AV +++ R+ EP +SSLY A+PF QDASVL++GERTNANGSK FRE Sbjct 306 TPEHLRQVVEAVRDLRAAGRRPRREPGLSSLYQAVPFQQDASVLMVGERTNANGSKAFRE 365 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AM+A+D+Q C++IA+ QTRDGAH+LDL VDYVGRDG ADM +LASRLAT+STLPIM+DST Sbjct 366 AMLAQDWQACIEIARAQTRDGAHVLDLNVDYVGRDGAADMASLASRLATASTLPIMIDST 425 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 E V+ AGLEHLGGR +NSVN+EDGDGP SR+ + M LVAEHGAAVVALTIDE+GQART Sbjct 426 EPEVIGAGLEHLGGRSIVNSVNFEDGDGPTSRYTRIMNLVAEHGAAVVALTIDEQGQART 485 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 + KV IAERLI D+TG WG+ ES I++D LTF IATGQEE+RRDGIETIEAIRELK+RH Sbjct 486 REHKVAIAERLIADLTGTWGMAESDIVVDCLTFPIATGQEETRRDGIETIEAIRELKRRH 545 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PD+ TLG+SN+SFGLNPAARQVLNSVFL EC AGLDSAIVH SKILPM RIPEEQR V Sbjct 546 PDLHFTLGISNVSFGLNPAARQVLNSVFLAECTAAGLDSAIVHPSKILPMARIPEEQRTV 605 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLV+DRRRE YDPLQ ++ +FEG + A+ + R AE+A LPL ERL +RI+DGERNGL Sbjct 606 ALDLVWDRRREGYDPLQRVLEMFEGATTAAGRATRAAEMAALPLDERLQRRIIDGERNGL 665 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 +ADLDEA+T + L+IIN+ LL GMKTVGELFGSG MQLPFVL SAEVMK AVAYLEPHM Sbjct 666 EADLDEALTMRSALEIINDTLLEGMKTVGELFGSGAMQLPFVLTSAEVMKTAVAYLEPHM 725 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 E++ D GKG IVLATVKGDVHDIGKNLVDIILSNNGY VVN+GIKQPIATIL A+D Sbjct 726 EKA-DSGGKGTIVLATVKGDVHDIGKNLVDIILSNNGYSVVNLGIKQPIATILSAAQDSG 784 Query 781 ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH 840 AD +GMSGLLVKSTV+MKENLEEMN RG+AEK+PVLLGGAALTRSYVENDL+ +++G+V Sbjct 785 ADAIGMSGLLVKSTVIMKENLEEMNARGIAEKYPVLLGGAALTRSYVENDLSSVFKGDVR 844 Query 841 YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRI---AAQRKA 897 YARDAFEGL+LMD +MS KRG P A K AERKARH+RSKRI A Sbjct 845 YARDAFEGLRLMDGVMSRKRGLDP----VAAAAETAKIAERKARHERSKRIAEKRKAAAA 900 Query 898 AEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGG 957 EE V+VP RSDVA D VP PPFWGSR++KG+A+ADY+ +LDERA F+GQWGLRG +GG Sbjct 901 EEEQVDVPARSDVATDNPVPTPPFWGSRVIKGIALADYSTMLDERATFMGQWGLRGSKGG 960 Query 958 EGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAP 1017 +GPSYE+LVE EGRPRLRYWLDRL TD +L AAVVYGYFP VSEG+D+VVL EP PDA Sbjct 961 QGPSYEELVEKEGRPRLRYWLDRLHTDKVL-EAAVVYGYFPCVSEGDDVVVLAEPTPDAA 1019 Query 1018 VRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNA 1077 RF FPRQ+R R LC++DF RSRE A + G+VDV+ F +VTMGQ IADFANELFA+NA Sbjct 1020 ELCRFTFPRQRRDRHLCLSDFYRSRESARQTGQVDVIAFTVVTMGQRIADFANELFAANA 1079 Query 1078 YRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFA 1137 YRDYLEVHG+ VQLTEALAE+WH+RIR EL F AAED E +F L YRGAR++ Sbjct 1080 YRDYLEVHGLSVQLTEALAEFWHQRIRSELVFPDGSNAAAEDSAEIEKFFDLEYRGARYS 1139 Query 1138 FGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYF 1190 FGY ACPDL D+ K+MALLEPERIGV LSEE QLHPEQST A V HHPEAKYF Sbjct 1140 FGYPACPDLTDQTKVMALLEPERIGVELSEEFQLHPEQSTSALVAHHPEAKYF 1192 >gi|213965602|ref|ZP_03393796.1| methionine synthase [Corynebacterium amycolatum SK46] gi|213951761|gb|EEB63149.1| methionine synthase [Corynebacterium amycolatum SK46] Length=1219 Score = 1674 bits (4336), Expect = 0.0, Method: Compositional matrix adjust. Identities = 841/1216 (70%), Positives = 979/1216 (81%), Gaps = 33/1216 (2%) Query 9 YDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNY 67 + ++ L L RV++GDGAMGTQLQ+ DL +D DF G EGCNEILN+TRPD++ETIHR Y Sbjct 5 HSSEFLTALHSRVLIGDGAMGTQLQSFDLDVDADFLGYEGCNEILNDTRPDIIETIHRRY 64 Query 68 FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVL 124 FEAGAD VETNTFGCN NL DYDI DRI++L+ KGTAIAR+VADE+G P R +R+VL Sbjct 65 FEAGADLVETNTFGCNFPNLADYDIEDRIQELAHKGTAIARKVADEMG-PGREGMRRFVL 123 Query 125 GSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRA 184 GS+GPGTKLP+LGH YA +RDAYTEA LGM+ GGADA L+ETCQDLLQ+KAAV G + A Sbjct 124 GSLGPGTKLPSLGHAPYAQLRDAYTEAGLGMISGGADAFLIETCQDLLQVKAAVNGVKAA 183 Query 185 MTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRH 244 M +A + IP+ HVTVETTGTML+GSEIGAAL A++PLG+DMIGLNCATGP EMSEHLR+ Sbjct 184 MRQADKKIPIVVHVTVETTGTMLMGSEIGAALAALQPLGIDMIGLNCATGPDEMSEHLRY 243 Query 245 LSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAH 304 LS A IPVSVMPNAGLPVLG GA YPL ELA AL GF+ EFGLS+VGGCCGTTP H Sbjct 244 LSSFASIPVSVMPNAGLPVLGKNGATYPLTAPELATALRGFVEEFGLSMVGGCCGTTPEH 303 Query 305 IREVAAAVANI------------KRPERQVSYEP--SVSSLYTAIPFAQDASVLVIGERT 350 + V A+ RP + +P V+SLY+A P Q + +IGERT Sbjct 304 VSAVRDAITGTGAYAEQGPAVQAARPSTDPNAKPIDEVASLYSATPLTQTTGITMIGERT 363 Query 351 NANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATS 410 NANGSK FREAM+A D++KCL+ A+ Q DGAH++DLCVDYVGRDG DM LAS++ATS Sbjct 364 NANGSKAFREAMLAGDWEKCLNTARGQVTDGAHMIDLCVDYVGRDGRDDMATLASQIATS 423 Query 411 STLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVAL 470 TLP+MLDSTE VL+ GLEHLGGRCA+NSVN+EDGDGP+SR+ + M V EHGAAVVAL Sbjct 424 VTLPVMLDSTEPEVLKTGLEHLGGRCAVNSVNFEDGDGPDSRYQRIMRQVVEHGAAVVAL 483 Query 471 TIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETI 530 TIDEEGQART KK+EIAERLI DITG WG+ E I++D LTF I+TGQEE+RRDGIETI Sbjct 484 TIDEEGQARTKDKKIEIAERLIADITGTWGLREQDIIVDCLTFPISTGQEETRRDGIETI 543 Query 531 EAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPM 590 EAIRELK+RHP+V TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLDSAI H+SKILPM Sbjct 544 EAIRELKRRHPNVHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDSAIAHSSKILPM 603 Query 591 NRIPEEQRNVALDLVYDRRRE------DYDPLQELMRLFEGVSAASSKEDRLAELAGLPL 644 N+I ++QR VALD+VYDRRRE +YDPLQ M LFEGVSAA +K+ R +LA +PL Sbjct 604 NKIDDKQREVALDMVYDRRREAGHPDGEYDPLQVFMELFEGVSAADAKDARAEQLAAMPL 663 Query 645 FERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQ 704 F+RLAQRI+DGER G++ADLDE+M +K PL I+NE LL GM+TVG+LFGSGQMQLPFVLQ Sbjct 664 FDRLAQRIIDGERTGIEADLDESMKEKEPLAIVNEDLLRGMQTVGDLFGSGQMQLPFVLQ 723 Query 705 SAEVMKAAVAYLEPHMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIG 764 SAE MKAAV YLE M+ D KG IVLATVKGDVHDIGKNLV+IILSNNGY V N+G Sbjct 724 SAETMKAAVGYLEGFMDAEDATGSKGSIVLATVKGDVHDIGKNLVEIILSNNGYTVHNLG 783 Query 765 IKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTR 824 IKQPIATIL A++ D +GMSGLLVKSTVVMK+NL E+N+ G A +FPVLLGGAALTR Sbjct 784 IKQPIATILSAAKELDVDAIGMSGLLVKSTVVMKDNLLEINSAGDAARFPVLLGGAALTR 843 Query 825 SYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKAR 884 SYVE+DL+E+Y G+V+Y RDAFEGL++MD +M+AK+G PDENSPEAI AREK+ R+AR Sbjct 844 SYVEDDLSELYHGDVYYGRDAFEGLRIMDELMAAKKGLGPDENSPEAIAAREKKEARRAR 903 Query 885 HQRSKRIAAQRKAAEEPV--EVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDER 942 +RSKRIAAQR A EVPERSDVAAD+ V PPFWG+RIVKGL + DY LDER Sbjct 904 RERSKRIAAQRAAKAAAEAPEVPERSDVAADVPVATPPFWGTRIVKGLPLDDYLTTLDER 963 Query 943 ALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSE 1002 ALF+GQWGLRG RG EGPSYE+LVE++GRPRLR WL RL + IL HAAVVYGYFPAVSE Sbjct 964 ALFMGQWGLRGTRGDEGPSYEELVESDGRPRLRAWLQRLRAENILQHAAVVYGYFPAVSE 1023 Query 1003 GNDIVVLT------EPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPF 1056 G+ + VL +P P A + FPRQQRGRFLCIADFIRSRE A G+ DV+PF Sbjct 1024 GDTVHVLPLPAEGEQPDPTAEPVVSWTFPRQQRGRFLCIADFIRSREDAIAAGQTDVMPF 1083 Query 1057 QLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMA 1116 QLVTMGQPIADFAN+++A N YRDYLEVHGIGVQLTEALAEYWH+RIR EL FS ++ Sbjct 1084 QLVTMGQPIADFANDIYAKNEYRDYLEVHGIGVQLTEALAEYWHQRIRSELAFSDGTSVG 1143 Query 1117 AEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQS 1176 AED + +D+F L YRGAR++FGYG+CPDL R M+ LL+PERIGV LSEELQLHPEQS Sbjct 1144 AEDSDDTQDFFDLKYRGARYSFGYGSCPDLTFRQGMIDLLQPERIGVELSEELQLHPEQS 1203 Query 1177 TDAFVLHHPEAKYFNV 1192 TDAFVL+HPEAKYFNV Sbjct 1204 TDAFVLYHPEAKYFNV 1219 >gi|237785511|ref|YP_002906216.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium kroppenstedtii DSM 44385] gi|237758423|gb|ACR17673.1| 5-methyltetrahydrofolate--homocysteinemethyltransferase [Corynebacterium kroppenstedtii DSM 44385] Length=1240 Score = 1667 bits (4316), Expect = 0.0, Method: Compositional matrix adjust. Identities = 825/1217 (68%), Positives = 961/1217 (79%), Gaps = 37/1217 (3%) Query 11 TDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDVLETIHRNYFE 69 ++ L L RV++GDGAMGTQLQA DL LD DF GLEGCNEILN TRPD+L IHR YFE Sbjct 26 SEFLQALHDRVLIGDGAMGTQLQAIDLDLDADFHGLEGCNEILNITRPDILADIHRRYFE 85 Query 70 AGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDR---KRYVLGS 126 AGADAVETNTFGCNL N DY I DRI +++ GT IAR VAD++G P R KR+VLGS Sbjct 86 AGADAVETNTFGCNLPNFADYGIEDRIEEIAYAGTQIARSVADDMG-PGREGMKRFVLGS 144 Query 127 MGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMT 186 +GPGTKLPTLG+ ++ +RDAYTEAA G++ GGADAIL+ET QDLLQ+KAAV G ++A Sbjct 145 LGPGTKLPTLGNAPFSDLRDAYTEAAHGLVRGGADAILIETAQDLLQVKAAVHGVQQAFD 204 Query 187 RAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLS 246 G +P+ HVTVETTGTMLLGSEIGAALTA+E LG+D+IG+NCATGP EM+EHLR+LS Sbjct 205 DYGTTLPIMCHVTVETTGTMLLGSEIGAALTALERLGIDVIGMNCATGPDEMNEHLRYLS 264 Query 247 RHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIR 306 HA +PVSVMPNAGLP LGA GA YPL PDELA A F+ ++GLS+VGGCCGTTP HI Sbjct 265 AHAPMPVSVMPNAGLPELGANGAVYPLTPDELAAASVHFVRDYGLSMVGGCCGTTPEHIT 324 Query 307 EVAAAVAN-------------IKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNAN 353 V AV + RP R ++ +VSSLY+ +P QD + +IGERTN+N Sbjct 325 AVRDAVIGSPDSQEDASESPAVTRPARHHDFDDNVSSLYSTVPLTQDTGITMIGERTNSN 384 Query 354 GSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTL 413 GSK FR AM+ D+ KCLDIAK QTRDGAH++DLCVDYVGRDG DM LASRLAT+STL Sbjct 385 GSKAFRTAMLEGDWNKCLDIAKAQTRDGAHMIDLCVDYVGRDGTQDMAELASRLATNSTL 444 Query 414 PIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTID 473 PIMLDSTE V++ GLEHLGGRCA+NSVN+EDGDGP SR+ + M LV +HGAAVVALTID Sbjct 445 PIMLDSTEPDVIRMGLEHLGGRCAVNSVNFEDGDGPGSRYDRIMTLVKKHGAAVVALTID 504 Query 474 EEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAI 533 EEGQARTA+KKVEIAERLI DIT WG+ ES I++D LTF I+TGQ E+RRDGIETI AI Sbjct 505 EEGQARTAEKKVEIAERLIADITTRWGLRESDIIVDCLTFPISTGQVETRRDGIETINAI 564 Query 534 RELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRI 593 RE+ RHPD+ TTLGLSNISFGLNPAARQVLNSVFL+EC EAGLD+AI H+SKI+PMNRI Sbjct 565 REITSRHPDIHTTLGLSNISFGLNPAARQVLNSVFLNECIEAGLDTAIAHSSKIVPMNRI 624 Query 594 PEEQRNVALDLVYDRR---------REDYDPLQELMRLFEGVSAASSKEDRLAELAGLPL 644 ++QR+VALD+VYDRR EDYDPLQ M LF+GVSAA +K+ R L LPL Sbjct 625 DDDQRDVALDMVYDRRGTEGRGGTADEDYDPLQTFMELFQGVSAADAKDARAEALQALPL 684 Query 645 FERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQ 704 F+RLAQRI+DGE+NGL+ADLD A +K PL+IIN+ LLAGMK VG+LFGSGQMQLPFVLQ Sbjct 685 FKRLAQRIIDGEKNGLEADLDLARDEKDPLEIINQDLLAGMKVVGDLFGSGQMQLPFVLQ 744 Query 705 SAEVMKAAVAYLEPHMERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIG 764 SAE MKAAV++LE ME +DD + KG+I+LATVKGDVHDIGKNLVDIILSNNGY+VVN+G Sbjct 745 SAETMKAAVSHLEQFMEATDDSASKGKIILATVKGDVHDIGKNLVDIILSNNGYDVVNLG 804 Query 765 IKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTR 824 IKQPI+ IL A + ADV+GMSGLLVKSTVVMK+NL EMN+ G A +PVLLGGAALTR Sbjct 805 IKQPISNILHAASEHQADVIGMSGLLVKSTVVMKDNLLEMNSAGAA-NYPVLLGGAALTR 863 Query 825 SYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRG---EAPDENSPEAIKAREKEAER 881 +YVENDL E+YQG+VHYARDAFEGL LMD IMS KRG E +E A +A++K+ ER Sbjct 864 TYVENDLDELYQGDVHYARDAFEGLNLMDQIMSMKRGSQRELTEEQIAAATRAQKKKEER 923 Query 882 KARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDE 941 KARH+RS++IAA+RKA P +P+RSDVA D + PPFWG+RIVKGL V DY LDE Sbjct 924 KARHERSRKIAAKRKAESAPAVIPDRSDVATDTPIATPPFWGTRIVKGLPVRDYLTCLDE 983 Query 942 RALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVS 1001 RALF+GQWGLRG RGG+GPSY++LVETEGRPRLR W++ L +GIL H+AVVYGYFPAVS Sbjct 984 RALFMGQWGLRGTRGGDGPSYDELVETEGRPRLRAWINDLKAEGILNHSAVVYGYFPAVS 1043 Query 1002 EGNDIVVLT------EPKPDAPVRYRFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLP 1055 EGN + +L EP P A F FPRQQRGRFLCIADFIRSR+ A G DV P Sbjct 1044 EGNTVHILPVPNEAEEPDPTAQPVTSFEFPRQQRGRFLCIADFIRSRDEAQRTGHTDVFP 1103 Query 1056 FQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAM 1115 QLVTMGQ IAD AN LF N YR+YLE+HGIGVQLTEALAEYWH R+R EL F+ Sbjct 1104 LQLVTMGQSIADKANVLFKDNHYREYLELHGIGVQLTEALAEYWHSRVRAELAFADGTHA 1163 Query 1116 AAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQ 1175 +D +F L YRGAR++FGYG+CPDLE R ++ LL PERIGV LSEELQLHPEQ Sbjct 1164 GDDDGTEDRAFFDLKYRGARYSFGYGSCPDLESRRALVDLLRPERIGVELSEELQLHPEQ 1223 Query 1176 STDAFVLHHPEAKYFNV 1192 STDAFVL+HPEAKYFNV Sbjct 1224 STDAFVLYHPEAKYFNV 1240 >gi|336325590|ref|YP_004605556.1| 5-methyltetrahydrofolate-homocysteinemethyltransferase [Corynebacterium resistens DSM 45100] gi|336101572|gb|AEI09392.1| 5-methyltetrahydrofolate-homocysteinemethyltransferase [Corynebacterium resistens DSM 45100] Length=1233 Score = 1654 bits (4284), Expect = 0.0, Method: Compositional matrix adjust. Identities = 830/1233 (68%), Positives = 975/1233 (80%), Gaps = 47/1233 (3%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLD-DFRGLEGCNEILNETRPDV 59 ++A + +D L+ L +RV++GDGAMGTQLQA +L LD DF GLEGCNEILNETRPDV Sbjct 7 LSAPAQPAFDHPFLNALRERVLIGDGAMGTQLQAVELDLDKDFLGLEGCNEILNETRPDV 66 Query 60 LETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGS-PD 118 L IHR YFEAGAD VETNTFGCNL NL DYDIADRI DL+ +G IAR VADE+G PD Sbjct 67 LRDIHRAYFEAGADLVETNTFGCNLPNLADYDIADRIEDLAYRGAKIAREVADEMGPRPD 126 Query 119 --RKRYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKA 176 +V+GSMGPGTKLP+LGH YA +RDAY E+A G++ GG DAIL+ETCQDLLQ+KA Sbjct 127 DGMPSFVVGSMGPGTKLPSLGHAPYAALRDAYVESARGLIRGGCDAILIETCQDLLQVKA 186 Query 177 AVLGSRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPA 236 AVLG+++A +P+ HVTVETTGTMLLGSE+GAALTA+EPLG+DMIG+NCATGP Sbjct 187 AVLGAKQAFEELETRVPIVVHVTVETTGTMLLGSEVGAALTALEPLGIDMIGMNCATGPD 246 Query 237 EMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGG 296 EMSEHLR+LS + +PVSVMPNAGLPVLGA GAEYPL EL AL GF+A++GLS+VGG Sbjct 247 EMSEHLRYLSNNTSLPVSVMPNAGLPVLGANGAEYPLTAPELGVALRGFVADYGLSMVGG 306 Query 297 CCGTTPAHI----------------------------REVAAAVANIKRPERQVSYEPSV 328 CCGTTP HI E+A VA + +R V+ +V Sbjct 307 CCGTTPEHITAVREAVLGTQSVSSGASETKEKGPIAHSELAPPVAPAVQAKRTVNVNNNV 366 Query 329 SSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLC 388 +SLY A+P QD + +IG+RTNANGSK FREAM+A D +KCL+IAKDQ RDGAH++DLC Sbjct 367 ASLYQAVPLTQDTGITMIGQRTNANGSKAFREAMLAGDLEKCLEIAKDQVRDGAHMVDLC 426 Query 389 VDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDG 448 +DYVGRDG DM LA+ LAT+STLPIM+DSTE V++ GLEHLGGR A+NSVN+EDGDG Sbjct 427 IDYVGRDGTEDMARLAALLATNSTLPIMIDSTEPDVIRVGLEHLGGRSAVNSVNFEDGDG 486 Query 449 PESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILI 508 P+SR+ + M LV +HGAAVVALTIDEEGQARTA+KKVEIAERLI DITG+WGV E I++ Sbjct 487 PDSRYQRIMRLVKQHGAAVVALTIDEEGQARTAEKKVEIAERLIADITGSWGVPEEDIIV 546 Query 509 DTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPAARQVLNSVF 568 D LTF I+TGQEE+R+DGIETI AIRELKKRHP V TTLGLSNISFGLNPAARQVLNSVF Sbjct 547 DCLTFPISTGQEETRKDGIETINAIRELKKRHPAVHTTLGLSNISFGLNPAARQVLNSVF 606 Query 569 LHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSA 628 L+EC EAGLD+AI H+SKILPMNRI EEQR VALD+VYDRR E YDPLQ M+LFEGVSA Sbjct 607 LNECIEAGLDTAIAHSSKILPMNRIDEEQRKVALDMVYDRRTEGYDPLQTFMQLFEGVSA 666 Query 629 ASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINEHLLAGMKTV 688 AS+K+ R LA +PLFERLAQRI+DG+RNGL DLDEAM +K P+ IINE LLAGMKTV Sbjct 667 ASAKDARAEALAAMPLFERLAQRIIDGDRNGLTDDLDEAMKEKDPVAIINEDLLAGMKTV 726 Query 689 GELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSG--KGRIVLATVKGDVHDIGK 746 G+LFGSG+MQLPFVLQSAE MKAAVA LEPHME S+ SG KG++V+ATVKGDVHDIGK Sbjct 727 GDLFGSGEMQLPFVLQSAETMKAAVANLEPHME-SEAGSGASKGKMVIATVKGDVHDIGK 785 Query 747 NLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNT 806 NLVDIILSNNGY+VVNIGIKQPI+ ILE AE+ +ADV+GMSGLLVKSTVVMKENLEE+N Sbjct 786 NLVDIILSNNGYDVVNIGIKQPISAILEAAEENNADVIGMSGLLVKSTVVMKENLEELNR 845 Query 807 RGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDE 866 G + +PV+LGGAALTR YVE+DL E+Y G+V+Y++DAFE L ++D IM+ RGE +E Sbjct 846 LGKSH-YPVMLGGAALTRPYVEDDLTEVYDGDVYYSKDAFEALTVLDGIMAGLRGEHTEE 904 Query 867 NSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRI 926 ++ +K ++ A R+ SK IAA+RK EPVEVP RSDVA D+ + PPFWG RI Sbjct 905 SAEVTVKREKRRARRER----SKAIAAKRKTNAEPVEVPARSDVAIDVPLATPPFWGPRI 960 Query 927 VKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLDRLSTDGI 986 VKG+++ADY LDERALF GQWGL R GP+YE+LVET+GRPRLR LD L ++G+ Sbjct 961 VKGISLADYLPNLDERALFRGQWGLMPSRAEAGPTYEELVETDGRPRLRALLDELKSNGV 1020 Query 987 LAHAAVVYGYFPAVSEGNDIVVLTEPK-------PDAPVRYRFHFPRQQRGRFLCIADFI 1039 L AAVVYGYFPAVSEG+ + L P P A + F FPRQQRGRFL IADFI Sbjct 1021 LDAAAVVYGYFPAVSEGDTVHFLPTPSSPAASADPHAKPIHSFTFPRQQRGRFLNIADFI 1080 Query 1040 RSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYW 1099 SRE A E G+ DV+PFQLVTMGQPIADFANELFA +AYR+YLEVHG+GVQLTEALAEYW Sbjct 1081 CSRERAIELGQTDVMPFQLVTMGQPIADFANELFAKDAYREYLEVHGVGVQLTEALAEYW 1140 Query 1100 HRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPE 1159 H RIR ELKF+ ED ED+F L YRGARF+FGYG+CPD+EDR ++ +LE E Sbjct 1141 HSRIRSELKFADGTTAGDEDSANMEDFFDLQYRGARFSFGYGSCPDMEDRRALVDMLEAE 1200 Query 1160 RIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 ++GV LSEELQLHPEQSTDAFVL+HPEAKYFNV Sbjct 1201 KLGVVLSEELQLHPEQSTDAFVLYHPEAKYFNV 1233 >gi|72162224|ref|YP_289881.1| methionine synthase (B12-dependent) [Thermobifida fusca YX] gi|71915956|gb|AAZ55858.1| methionine synthase (B12-dependent) [Thermobifida fusca YX] Length=1158 Score = 1623 bits (4203), Expect = 0.0, Method: Compositional matrix adjust. Identities = 800/1178 (68%), Positives = 936/1178 (80%), Gaps = 28/1178 (2%) Query 15 DVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGADA 74 +VL RV+V DGAMGT LQ DL++DDF G EGCNE+LN TRPDV+ IH Y +AG D Sbjct 9 EVLGSRVLVADGAMGTMLQTYDLSMDDFEGHEGCNEVLNITRPDVVREIHEAYLQAGVDC 68 Query 75 VETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTKLP 134 VETNTFG N NLG+Y IA+R +L++ G +AR AD + D RYVLGS+GPGTKLP Sbjct 69 VETNTFGANFGNLGEYGIAERTYELAEAGARLAREAADAYTTADHVRYVLGSVGPGTKLP 128 Query 135 TLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHIPV 194 TLGH YAV+RD Y + A G++DGG DAI++ETCQDLLQ KAA++G+RRA AG P+ Sbjct 129 TLGHAPYAVLRDHYEQCARGLIDGGVDAIVIETCQDLLQAKAAIVGARRARKAAGTDTPI 188 Query 195 FAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIPVS 254 VT+ETTGTML+GSEIGAALT++EPLGVDMIGLNCATGPAEMSEHLR+LS H+RIP+S Sbjct 189 IVQVTIETTGTMLVGSEIGAALTSLEPLGVDMIGLNCATGPAEMSEHLRYLSHHSRIPLS 248 Query 255 VMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAVAN 314 MPNAGLP LGA GA YPL P EL EA FI EFGL+LVGGCCGTTP H+ +V V Sbjct 249 CMPNAGLPELGADGAVYPLQPHELTEAHDTFIREFGLALVGGCCGTTPEHLAQVVERVQG 308 Query 315 IKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIA 374 P+R+ EP+ +S+Y ++PF QD S L IGERTNANGSK FREAM+AE Y C++IA Sbjct 309 RGVPDRKPHVEPAAASIYQSVPFRQDTSYLAIGERTNANGSKAFREAMLAERYDDCVEIA 368 Query 375 KDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHLGG 434 + Q RDGAH+LDLCVDYVGRDGV DM+ LASRLAT+STLP++LDSTE AVL+AGLE LGG Sbjct 369 RQQIRDGAHMLDLCVDYVGRDGVRDMRELASRLATASTLPLVLDSTEVAVLEAGLEMLGG 428 Query 435 RCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLIND 494 R +NSVNYEDGDGP+SRFAK AL EHGAA++ALTIDE+GQARTA++KVE+AERLI Sbjct 429 RAVLNSVNYEDGDGPDSRFAKVAALAVEHGAALMALTIDEQGQARTAERKVEVAERLIRQ 488 Query 495 ITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISF 554 +T +G+ + I++D LTFTIATGQEESRRD +ETIEAIRELK+RHPDVQTTLG+SN+SF Sbjct 489 LTTEYGIRKHDIIVDCLTFTIATGQEESRRDALETIEAIRELKRRHPDVQTTLGVSNVSF 548 Query 555 GLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYD 614 GLNPAAR VLNSVFLHEC +AGLDSAIVHASKILP+NRIPEEQR VALD++YDRR +DYD Sbjct 549 GLNPAARIVLNSVFLHECVQAGLDSAIVHASKILPINRIPEEQRQVALDMIYDRRTDDYD 608 Query 615 PLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPL 674 PLQ ++LFEGV A + + R ELA LPL+ERL +RIVDGE G++ADLDEA+TQ+ L Sbjct 609 PLQRFLQLFEGVDAQAMRASREEELAALPLWERLERRIVDGEAAGMEADLDEALTQRSAL 668 Query 675 QIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGRIVL 734 IIN LLAGMKTVG+LFGSGQMQLPFVL+SAEVMKAAVAYLEPHME+ D D GKGRIVL Sbjct 669 DIINTTLLAGMKTVGDLFGSGQMQLPFVLKSAEVMKAAVAYLEPHMEKVDGDLGKGRIVL 728 Query 735 ATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKST 794 ATVKGDVHDIGKNLVDIILSNNGYEV+N+GIKQPI+ ILE AE ADV+GMSGLLVKST Sbjct 729 ATVKGDVHDIGKNLVDIILSNNGYEVINLGIKQPISAILEAAERHRADVIGMSGLLVKST 788 Query 795 VVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDT 854 VVM+ENLEEMN RGVA+++PVLLGGAALTRSYVE DLAEI++GEV YARDAFEGLKLMD Sbjct 789 VVMRENLEEMNARGVADRYPVLLGGAALTRSYVEQDLAEIFKGEVRYARDAFEGLKLMDA 848 Query 855 IMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADI 914 IM+ KRG +K + R R +R ++ EP ++P RSDVA D Sbjct 849 IMAVKRG----------VKGAKLPPLRTRRVKRGAQLTVT-----EPEKMPTRSDVATDN 893 Query 915 EVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRL 974 VP PPFWG RI KG+ +ADY LDERA F+GQWGLRG R G+GP+YE+LVETEGRPRL Sbjct 894 PVPTPPFWGDRICKGIPLADYAAFLDERATFMGQWGLRGSR-GDGPTYEELVETEGRPRL 952 Query 975 RYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLC 1034 R WLDR+ T+G L AVVYGY+ SEGND+VVL E D RF FPRQ+R R LC Sbjct 953 RMWLDRIQTEGWL-EPAVVYGYYRCYSEGNDLVVLGE---DENELTRFTFPRQRRDRHLC 1008 Query 1035 IADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEA 1094 +ADF R + E GE+D + FQ+VT+G I+ ELF NAYRDYLE+HG+ VQLTEA Sbjct 1009 LADFFRPK----ESGELDTVAFQVVTVGSTISKATAELFEKNAYRDYLELHGLSVQLTEA 1064 Query 1095 LAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMA 1154 LAEYWH R+R EL F+G+ DP + YFKLGYRGARF+ GYGACP+LEDRAK++A Sbjct 1065 LAEYWHTRVRAELGFAGEDP----DPADLDAYFKLGYRGARFSLGYGACPNLEDRAKIVA 1120 Query 1155 LLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 LL PER+GVTLSEE QL PEQSTDA V+HHPEAKYFNV Sbjct 1121 LLRPERVGVTLSEEFQLVPEQSTDAIVVHHPEAKYFNV 1158 >gi|330468543|ref|YP_004406286.1| methionine synthase [Verrucosispora maris AB-18-032] gi|328811514|gb|AEB45686.1| methionine synthase [Verrucosispora maris AB-18-032] Length=1167 Score = 1609 bits (4167), Expect = 0.0, Method: Compositional matrix adjust. Identities = 793/1180 (68%), Positives = 945/1180 (81%), Gaps = 16/1180 (1%) Query 13 LLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGA 72 +LD L+ R+++ DGAMGT LQAADL+LDDF GLEGCNEILN TRPDV+ +H Y AGA Sbjct 1 MLDALADRILITDGAMGTMLQAADLSLDDFDGLEGCNEILNVTRPDVVRGVHEAYLAAGA 60 Query 73 DAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTK 132 D +ETNTFG NL NL +YDIADRI +LS+ G +AR AD +P+R R+VLGS+GPGTK Sbjct 61 DCIETNTFGANLPNLAEYDIADRIWELSEAGARLAREAADAYETPERPRWVLGSIGPGTK 120 Query 133 LPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHI 192 LPTLGH YA +RDAY + A G++ GGADA+++ETCQDLLQ+KAAV+GS+RAM AGR + Sbjct 121 LPTLGHASYASLRDAYQQNAGGLIAGGADALIIETCQDLLQVKAAVIGSKRAMAEAGRQV 180 Query 193 PVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIP 252 P+ HV VETTGTMLLGSEIGAALTA+EPLGVD+IGLNC+TGPAEM EHLR+LS+H+ +P Sbjct 181 PIICHVAVETTGTMLLGSEIGAALTAIEPLGVDLIGLNCSTGPAEMGEHLRYLSQHSTVP 240 Query 253 VSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAV 312 VSVMPNAGLPVL + GA +PL P+++AEAL F+ ++G++LVGGCCGTTP HIR +A + Sbjct 241 VSVMPNAGLPVLTSDGAYFPLGPEDMAEALERFVVDYGVALVGGCCGTTPEHIRVLAERL 300 Query 313 ANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLD 372 ++ R+ + VSS+Y +PFAQDASVL++GERTNANGSK FREAM+A D+Q C++ Sbjct 301 RDVAPVAREPRIDAGVSSIYHHVPFAQDASVLMVGERTNANGSKAFREAMLAADWQACVE 360 Query 373 IAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHL 432 IA+ Q RDG+HLLDLCVDYVGRDG DM+ LA R AT+STLPIMLDSTE AV++AGLE L Sbjct 361 IARSQARDGSHLLDLCVDYVGRDGTVDMRELAGRFATASTLPIMLDSTEPAVIEAGLEML 420 Query 433 GGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLI 492 GGRC +NSVN+EDGDGP+SR+A+ M +VAEHGAAVVAL IDEEGQARTA+ KV +AERLI Sbjct 421 GGRCVVNSVNFEDGDGPDSRYARVMPVVAEHGAAVVALLIDEEGQARTAEWKVRVAERLI 480 Query 493 NDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNI 552 ND+T WG+ + ILID LTF IATGQEE+RRDGIETIEAIRE+ +R P V TLG+SN+ Sbjct 481 NDLTERWGLRRADILIDALTFPIATGQEETRRDGIETIEAIREIARRWPGVNFTLGISNV 540 Query 553 SFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRRED 612 SFGLNPAARQVLNSVFLHEC +AGL SAIVHASKILPM +IPE+QR +ALDL+YDRRRE Sbjct 541 SFGLNPAARQVLNSVFLHECVQAGLTSAIVHASKILPMAKIPEQQREIALDLIYDRRREG 600 Query 613 YDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQ-K 671 YDP+Q + +FEGV AAS++ R ELA LPL ERL +RI+DGERNGL+ADLD AM Sbjct 601 YDPVQRFIEVFEGVDAASARATRAEELAALPLNERLKRRIIDGERNGLEADLDAAMAAGT 660 Query 672 PPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGR 731 PL IIN+ LL GMK VGELFGSGQMQLPFVLQSAEVMK AVAYLEPHME++ DD GKGR Sbjct 661 APLAIINDILLDGMKVVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHMEKA-DDGGKGR 719 Query 732 IVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLV 791 IVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPI+ IL+ AE AD +GMSGLLV Sbjct 720 IVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPISAILDAAEQHRADAIGMSGLLV 779 Query 792 KSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKL 851 KSTV+MKENL EM +RGVAE++PVLLGGAALTR+YVE+DL ++ G+VHYARDAFEGL L Sbjct 780 KSTVIMKENLAEMASRGVAERWPVLLGGAALTRAYVEDDLRSMFPGQVHYARDAFEGLSL 839 Query 852 MDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVA 911 MD +M+AKRG AP I + A R +R ++ A ++ E + RSDVA Sbjct 840 MDRVMTAKRGGAP------VIDPEREAALAARRARRERQRAVVAESLPELTDTSVRSDVA 893 Query 912 ADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGR 971 AD+ VP PF+G+R+VKG+ +ADY LLDERA F+GQWGLRG RGG+GPSY +LVETEGR Sbjct 894 ADVPVPTAPFYGTRVVKGVPLADYAALLDERATFMGQWGLRGARGGKGPSYVELVETEGR 953 Query 972 PRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGR 1031 PRLRYWLDRL D +L AAVVYGYFPA SEGND+VVL E R RF FPRQ++ R Sbjct 954 PRLRYWLDRLIADQVL-EAAVVYGYFPAYSEGNDLVVLDENGHAE--RARFTFPRQRQER 1010 Query 1032 FLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQL 1091 LC+ADF R R E+DV+ QLVT+GQP++++A +LFA N YRDYLEVHG+ VQL Sbjct 1011 RLCLADFFRPRG-----EELDVVALQLVTVGQPVSEYAAKLFARNEYRDYLEVHGLSVQL 1065 Query 1092 TEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAK 1151 TEALAEYWH+R+R EL R +A +DP + YRG R+AFGY ACPDLEDRAK Sbjct 1066 TEALAEYWHKRVRAELTLPDGRTVADDDPTDLAGLLRTDYRGCRYAFGYPACPDLEDRAK 1125 Query 1152 MMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 ++ LL ERIGV LSEE QL PEQ+TDA V+HHPEA YFN Sbjct 1126 IVELLGAERIGVQLSEEFQLMPEQATDAIVVHHPEASYFN 1165 >gi|323719336|gb|EGB28477.1| 5-methyltetrahydrofolate-homocysteine methyltransferase metH [Mycobacterium tuberculosis CDC1551A] Length=835 Score = 1608 bits (4163), Expect = 0.0, Method: Compositional matrix adjust. Identities = 793/794 (99%), Positives = 794/794 (100%), Gaps = 0/794 (0%) Query 1 VTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 +TAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL Sbjct 1 MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL 60 Query 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK Sbjct 61 ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK 120 Query 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG Sbjct 121 RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG 180 Query 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE Sbjct 181 SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE 240 Query 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT Sbjct 241 HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT 300 Query 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE Sbjct 301 TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE 360 Query 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST Sbjct 361 AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST 420 Query 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART Sbjct 421 ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART 480 Query 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH Sbjct 481 AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH 540 Query 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV Sbjct 541 PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV 600 Query 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL Sbjct 601 ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL 660 Query 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM Sbjct 661 DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM 720 Query 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS Sbjct 721 ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS 780 Query 781 ADVVGMSGLLVKST 794 ADVVGMSGLLVKST Sbjct 781 ADVVGMSGLLVKST 794 >gi|345013971|ref|YP_004816325.1| methionine synthase [Streptomyces violaceusniger Tu 4113] gi|344040320|gb|AEM86045.1| methionine synthase [Streptomyces violaceusniger Tu 4113] Length=1168 Score = 1606 bits (4158), Expect = 0.0, Method: Compositional matrix adjust. Identities = 802/1172 (69%), Positives = 924/1172 (79%), Gaps = 29/1172 (2%) Query 20 RVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGADAVETNT 79 RV+V DGAMGT LQA D +LDDF+ LEGCNEILN TRPD++ ++H Y+ AG D VETNT Sbjct 24 RVVVADGAMGTMLQAQDPSLDDFQQLEGCNEILNVTRPDIVRSVHAEYYAAGVDCVETNT 83 Query 80 FGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTKLPTLGHT 139 FG N + LG+YDI DR+ +LS+ G IAR VADE + R+R+VLGSMGPGTKLPTLGH Sbjct 84 FGANHAALGEYDIPDRVHELSEAGARIAREVADEFAADGRQRWVLGSMGPGTKLPTLGHA 143 Query 140 EYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHIPVFAHVT 199 Y +RDAY A GM+ GGADA+LVET QDLLQ KAAVLG+RRA+ G +P+ VT Sbjct 144 PYVTLRDAYQANAEGMIAGGADALLVETTQDLLQTKAAVLGARRALDATGVSLPLICSVT 203 Query 200 VETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIPVSVMPNA 259 VETTGTMLLGSEIGAALTA+EPLG+DMIGLNCATGPAEMSEHLRHL+RH+RIP+S MPNA Sbjct 204 VETTGTMLLGSEIGAALTALEPLGIDMIGLNCATGPAEMSEHLRHLARHSRIPLSCMPNA 263 Query 260 GLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAVANIKRPE 319 GLPVLG GA YPL P ELA+A F+ E+GLSLVGGCCGTTP H+R+V V + E Sbjct 264 GLPVLGKDGAHYPLSPGELADAQETFVREYGLSLVGGCCGTTPEHLRQVVERVREMTPTE 323 Query 320 RQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIAKDQTR 379 R EP +SLY +PF QD S L IGERTNANGSK FR+AM+ + C++IA++Q R Sbjct 324 RSPRPEPGAASLYQTVPFRQDTSYLAIGERTNANGSKKFRDAMLEARWDDCVEIAREQIR 383 Query 380 DGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHLGGRCAIN 439 +GAHLLDLCVDYVGRDGVADM+ LA R AT+STLP++LDSTE V++AGLE LGGR IN Sbjct 384 EGAHLLDLCVDYVGRDGVADMEELAGRFATASTLPLVLDSTEVDVIRAGLEKLGGRAVIN 443 Query 440 SVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLINDITGNW 499 SVNYEDGDGPESRFAK L EHGAA++ALTIDEEGQART + KVEIAERLI D+TGNW Sbjct 444 SVNYEDGDGPESRFAKVTRLAQEHGAALIALTIDEEGQARTPEHKVEIAERLIADLTGNW 503 Query 500 GVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISFGLNPA 559 G+ ES ILIDTLTFTI TGQEESR+DGI TIEAIRELK+RHPDVQTTLGLSNISFGLNPA Sbjct 504 GIHESDILIDTLTFTICTGQEESRKDGIATIEAIRELKRRHPDVQTTLGLSNISFGLNPA 563 Query 560 ARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYDPLQEL 619 AR VLNSVFL EC +AGLDSAIVHASKILP+ R EEQ ALDL+YDRR E YDPLQ+L Sbjct 564 ARIVLNSVFLDECVKAGLDSAIVHASKILPIARFEEEQVKTALDLIYDRRAEGYDPLQKL 623 Query 620 MRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPLQIINE 679 M LFEG +A S K + ELA LPL ERL +RI+DGERNGL+ADLDEA+ ++P LQI+NE Sbjct 624 MGLFEGATAKSLKAGKAEELAALPLDERLKRRIIDGERNGLEADLDEALQERPALQIVNE 683 Query 680 HLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGRIVLATVKG 739 LL GMK VGELFGSGQMQLPFVLQSAEVMK AVA+LEPHME+SDD+ GKG IVLATV+G Sbjct 684 TLLDGMKVVGELFGSGQMQLPFVLQSAEVMKTAVAHLEPHMEKSDDE-GKGTIVLATVRG 742 Query 740 DVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKE 799 DVHDIGKNLVDIILSNNGY VVN+GIKQP++ ILE AE+ ADV+GMSGLLVKSTV+MKE Sbjct 743 DVHDIGKNLVDIILSNNGYNVVNLGIKQPVSAILEAAEEHRADVIGMSGLLVKSTVIMKE 802 Query 800 NLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAK 859 NLEE+N R +A +FPV+LGGAALTR+YVE DL EIY+GEV YARDAFEGL+LMD +++ K Sbjct 803 NLEELNQRKLAAQFPVILGGAALTRAYVEQDLHEIYEGEVRYARDAFEGLRLMDALIAVK 862 Query 860 RGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAP 919 RG P PE R +R + AAQ + EP E P RSDV+ D +P P Sbjct 863 RG-VPGAALPE------------LRQRRVPQRAAQVREP-EPDEGPARSDVSTDNPLPTP 908 Query 920 PFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRLRYWLD 979 PFWG+R+VKG+ ADY LDE ALF GQWGL+ R G+GP YE+LVE EGRPRLR WLD Sbjct 909 PFWGTRVVKGIQQADYASWLDEGALFKGQWGLKQARTGDGPGYEELVENEGRPRLRGWLD 968 Query 980 RLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLCIADFI 1039 RL T G L AAVVYGYFP VS+G+D+V+L E D R RF FPRQ+RGR LC+ADF Sbjct 969 RLHT-GNLLEAAVVYGYFPCVSKGDDLVLLNE---DGSERTRFTFPRQRRGRRLCLADFF 1024 Query 1040 RSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYW 1099 R E GE DV+ Q+VT+G I + ELFA+++YRDYLE+HG+ VQL EALAEYW Sbjct 1025 RPE----ESGETDVVGLQVVTVGSKIGEATAELFAADSYRDYLELHGLSVQLAEALAEYW 1080 Query 1100 HRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLEPE 1159 H R+R EL F+G EDP ED F L YRGARF+ GYGACPDLEDRAK+ LL+PE Sbjct 1081 HARVRGELGFAG------EDPSEMEDMFALKYRGARFSLGYGACPDLEDRAKIADLLQPE 1134 Query 1160 RIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 RIGV LSEE QLHPEQSTDA V+HHPEAKYFN Sbjct 1135 RIGVKLSEEFQLHPEQSTDAIVIHHPEAKYFN 1166 >gi|271967199|ref|YP_003341395.1| methionine synthase [Streptosporangium roseum DSM 43021] gi|270510374|gb|ACZ88652.1| methionine synthase [Streptosporangium roseum DSM 43021] Length=1154 Score = 1603 bits (4150), Expect = 0.0, Method: Compositional matrix adjust. Identities = 785/1178 (67%), Positives = 935/1178 (80%), Gaps = 32/1178 (2%) Query 15 DVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGADA 74 +VL++RVMV DGAMGT LQA D+TLDDF G EGCNE+LN TRPD++ +H YFE G D Sbjct 9 EVLAERVMVADGAMGTMLQAHDVTLDDFEGHEGCNEVLNATRPDIVRAVHDAYFEVGVDC 68 Query 75 VETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTKLP 134 VETNTFG NL+ LG+YDI++R +LS+ G +AR AD +PD RYVLGS+GPGTKLP Sbjct 69 VETNTFGANLAALGEYDISERTHELSEAGARVAREAADHWSTPDHPRYVLGSIGPGTKLP 128 Query 135 TLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHIPV 194 TLGH Y V+RDAY + A G++ GGADA+++ETCQDLLQ+KAAV+G++RA+T +GR +PV Sbjct 129 TLGHKPYGVLRDAYYDNAAGLIAGGADALIIETCQDLLQVKAAVIGAKRAITDSGRDVPV 188 Query 195 FAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIPVS 254 A VTVET G MLLGSEIGAALTA+EPLGVD+IGLNCATGPAEMSEHLR+LSRHAR+ +S Sbjct 189 IAQVTVETNGAMLLGSEIGAALTAIEPLGVDVIGLNCATGPAEMSEHLRYLSRHARLQLS 248 Query 255 VMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAVAN 314 MPNAGLP L + GA YPL PDELA+A F FGLSLVGGCCGTTP H+R+V V Sbjct 249 CMPNAGLPQLTSDGAYYPLTPDELADAHENFTRSFGLSLVGGCCGTTPEHLRKVVERVRG 308 Query 315 IKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLDIA 374 R+ E +SLY +PF QD S L IGERTNANGSK FREAM+AE++++C++IA Sbjct 309 NGHSPRRPRPEAGAASLYQHVPFRQDTSYLAIGERTNANGSKAFREAMLAENWEECVEIA 368 Query 375 KDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHLGG 434 + Q RDGAH+LDLC+DYVGRDGV DMK LA R AT+STLPI+LDSTE AVL+AGLE +GG Sbjct 369 RAQARDGAHMLDLCIDYVGRDGVRDMKELAFRFATASTLPIVLDSTEPAVLEAGLEMIGG 428 Query 435 RCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLIND 494 R INSVNYEDGDGP+SRF + M LV HGAAV+ALTIDEEGQARTA+ K+ IA RLI D Sbjct 429 RAIINSVNYEDGDGPDSRFTRIMKLVRSHGAAVMALTIDEEGQARTAEWKLRIATRLIED 488 Query 495 ITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNISF 554 +T NWG++ I+ID LTF IATGQEE+RRDG+ETIEAIRELK+R+P VQT LGLSNISF Sbjct 489 LTANWGMNVEDIIIDALTFPIATGQEETRRDGVETIEAIRELKRRYPGVQTVLGLSNISF 548 Query 555 GLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRREDYD 614 GLNPAAR VLNSVFL+EC AGLDSAIVHASKILPM RIP+EQR VALD+VYDRRRE YD Sbjct 549 GLNPAARIVLNSVFLNECVNAGLDSAIVHASKILPMARIPDEQRQVALDMVYDRRREGYD 608 Query 615 PLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQKPPL 674 PLQ M LFEGV AAS K DR AEL GLPL+ERL +RI+DGER GL+ADLDEA+ Q+P L Sbjct 609 PLQRFMELFEGVDAASIKADRAAELLGLPLWERLKRRIIDGERKGLEADLDEALAQRPAL 668 Query 675 QIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGRIVL 734 +I+N+ LL GMKTVGELFGSGQMQLPFVLQSAEVMK +VAYLEPHM+R + ++ KGRIVL Sbjct 669 EIVNDVLLDGMKTVGELFGSGQMQLPFVLQSAEVMKTSVAYLEPHMDRVEGEN-KGRIVL 727 Query 735 ATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLVKST 794 ATVKGDVHDIGKNLVDIILSNNGYEVVN+GIKQP++ ILE AE++ ADV+GMSGLLVKST Sbjct 728 ATVKGDVHDIGKNLVDIILSNNGYEVVNLGIKQPVSAILEAAEEQKADVIGMSGLLVKST 787 Query 795 VVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKLMDT 854 V+MKENLEEMN+RG++E+FPVLLGGAALTR+YVE DLAE++QG+V YARDAFEGL+LMD Sbjct 788 VIMKENLEEMNSRGMSERFPVLLGGAALTRAYVEQDLAELFQGDVRYARDAFEGLRLMDA 847 Query 855 IMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVAADI 914 M+ KRGEA P R +R K A + E E+P RSDVAAD Sbjct 848 FMAVKRGEAGASLPP-------------LRERRVKTGATLVRTPE--AELPARSDVAADN 892 Query 915 EVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGRPRL 974 VP PF G RI+KG+ +ADY LDERA F+GQWGL+ RGG+GPSYE+LVETEGRPRL Sbjct 893 PVPTAPFLGERIIKGIPLADYAAFLDERATFMGQWGLKAARGGDGPSYEELVETEGRPRL 952 Query 975 RYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGRFLC 1034 R WL+R+ T+G+L AAV YGYFP VS+G+ +++L + + R RF FPRQ+R R LC Sbjct 953 RMWLERMQTEGLL-EAAVAYGYFPCVSDGDSLIILDDAGNE---RTRFTFPRQRRDRHLC 1008 Query 1035 IADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEA 1094 ++DF RS+ + GEVDV+ Q+ TMG +++ A ELFA +AYRDYLE+HG+ VQLTEA Sbjct 1009 LSDFFRSK----DSGEVDVVALQVATMGNRVSEAAAELFAKDAYRDYLELHGLSVQLTEA 1064 Query 1095 LAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMA 1154 LAEYWH R+R EL GD E+ ED K+ G R++FGY ACP+LED+ ++M Sbjct 1065 LAEYWHARVRSELGIGGD--------ESLEDMLKVNVTGCRYSFGYPACPNLEDQVQLME 1116 Query 1155 LLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV 1192 L++P RIGV LSEE QLHPEQST A V+HHPEA YFNV Sbjct 1117 LIDPSRIGVNLSEEFQLHPEQSTSALVVHHPEASYFNV 1154 >gi|315506202|ref|YP_004085089.1| methionine synthase [Micromonospora sp. L5] gi|315412821|gb|ADU10938.1| methionine synthase [Micromonospora sp. L5] Length=1171 Score = 1598 bits (4138), Expect = 0.0, Method: Compositional matrix adjust. Identities = 795/1180 (68%), Positives = 938/1180 (80%), Gaps = 16/1180 (1%) Query 13 LLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGA 72 L D+L+ R+++ DGAMGT LQAADLTLDDF GLEGCNEILN TRPDV+ +H Y AGA Sbjct 5 LRDLLADRILIADGAMGTMLQAADLTLDDFDGLEGCNEILNVTRPDVVRGVHDAYLAAGA 64 Query 73 DAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTK 132 D VETNTFG NL NL +Y I RIR+LS+ G IAR AD + + R+VLGSMGPGTK Sbjct 65 DCVETNTFGANLPNLAEYGIPGRIRELSEAGARIAREAADAYATEEHPRFVLGSMGPGTK 124 Query 133 LPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHI 192 LPTLGH YA +RDAY E A G++ GGADA+++ETCQDLLQ+KAAV+GS+RA AGR + Sbjct 125 LPTLGHASYASLRDAYQENAAGLIAGGADALIIETCQDLLQVKAAVVGSKRARAEAGRDV 184 Query 193 PVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIP 252 P+ V VETTGTMLLGSEIGAALTA+EPLGVD+IGLNC+TGPAEM EHLR+L++H+RIP Sbjct 185 PIICQVAVETTGTMLLGSEIGAALTAIEPLGVDLIGLNCSTGPAEMGEHLRYLAQHSRIP 244 Query 253 VSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAV 312 +SVMPNAGLPVL A GA +PL PDELA+AL F+ ++G++L+GGCCGTTP HIR + + Sbjct 245 ISVMPNAGLPVLTADGAYFPLSPDELADALEQFVTDYGVALIGGCCGTTPEHIRVLVERL 304 Query 313 ANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLD 372 R+ E VSS+Y +PFAQDAS+L++GERTNANGSK FRE+M+A D+Q C++ Sbjct 305 GGRAPVAREPEPEAGVSSIYHHVPFAQDASILMVGERTNANGSKAFRESMLAGDWQACVE 364 Query 373 IAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHL 432 +A+ Q RDG+HLLDLCVDYVGRDG DM+ LA R AT+STLPI+LDSTE AV++AGLE L Sbjct 365 VARSQARDGSHLLDLCVDYVGRDGTQDMRELAGRFATASTLPIVLDSTEPAVIEAGLEML 424 Query 433 GGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLI 492 GGRC +NSVN+EDGDGPESR+A+ M +V EHGAAVVAL IDEEGQART + KV +A RLI Sbjct 425 GGRCVVNSVNFEDGDGPESRYARIMPVVREHGAAVVALLIDEEGQARTREWKVRVACRLI 484 Query 493 NDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNI 552 +D+TG WG+ ILID LTF IATGQEE+RRDGIETIEAIRE+ R+P V T G+SN+ Sbjct 485 DDLTGRWGMRREDILIDALTFPIATGQEETRRDGIETIEAIREIAARYPGVNFTAGISNV 544 Query 553 SFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRRED 612 SFGLNPAARQVLNSVFLHEC +AGL SAIVHASKILPM+RIP+EQR VALDLVYDRRRE Sbjct 545 SFGLNPAARQVLNSVFLHECAQAGLTSAIVHASKILPMSRIPDEQREVALDLVYDRRREG 604 Query 613 YDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQ-K 671 YDP+Q + FEGV AAS++ R ELA LPL ERL +RI+DGERNGL+ADLD AM Q + Sbjct 605 YDPVQRFIEAFEGVDAASARATRAEELAALPLDERLKRRIIDGERNGLEADLDTAMAQGR 664 Query 672 PPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGR 731 PL IIN+ LL GMK VGELFGSGQMQLPFVLQSAEVMK AVAYLEPHME++DDD GKGR Sbjct 665 TPLSIINDLLLDGMKVVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHMEKTDDD-GKGR 723 Query 732 IVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLV 791 IVLATVKGDVHDIGKNLVDIILSNNGY+VVNIGIKQPI IL+ AE+ AD +GMSGLLV Sbjct 724 IVLATVKGDVHDIGKNLVDIILSNNGYDVVNIGIKQPINAILDAAEEHRADAIGMSGLLV 783 Query 792 KSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKL 851 KSTV+MKENL EM +RGVAE++PVLLGGAALTR+YVE+DL IY G+VHYARDAFEGL L Sbjct 784 KSTVIMKENLAEMASRGVAERWPVLLGGAALTRAYVEDDLRSIYPGQVHYARDAFEGLSL 843 Query 852 MDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVA 911 MD +M+AKRG AP + + A R +R ++ A R+A E + RSDVA Sbjct 844 MDRVMAAKRGGAP------MVDPEREAALAARRERRERQRAQVREALPELDDASVRSDVA 897 Query 912 ADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGR 971 D+ VP PPF+G+R+VKG+ +ADY LLDERA FLGQWGLRG RGG+GPSYE+LVETEGR Sbjct 898 VDVTVPKPPFFGTRVVKGVPLADYAALLDERATFLGQWGLRGARGGKGPSYEELVETEGR 957 Query 972 PRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGR 1031 PRLRYWLDRL +D +L AAVVYGYFPA SEGND+VVL E R RF FPRQ++ R Sbjct 958 PRLRYWLDRLISDQVL-EAAVVYGYFPAYSEGNDLVVLDENGHSE--RARFSFPRQRQER 1014 Query 1032 FLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQL 1091 LC+ADF R + ++DV+ QLVT+GQPI+++ ++FA N YRDYLEVHG+ VQL Sbjct 1015 RLCLADFFRPKG-----DQLDVVALQLVTVGQPISEYTAKMFAGNEYRDYLEVHGLSVQL 1069 Query 1092 TEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAK 1151 TEALAEYWHRRIR EL G +A +DP + YRG R+AFGY ACPDLEDRAK Sbjct 1070 TEALAEYWHRRIRAELVLPGGGTVADDDPADLAGLLRTDYRGCRYAFGYPACPDLEDRAK 1129 Query 1152 MMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 ++ LL ERIGV LSEE QL PEQ+TDA V+HHPEA YFN Sbjct 1130 IVELLGAERIGVQLSEEFQLVPEQATDAIVVHHPEANYFN 1169 >gi|302867394|ref|YP_003836031.1| methionine synthase [Micromonospora aurantiaca ATCC 27029] gi|302570253|gb|ADL46455.1| methionine synthase [Micromonospora aurantiaca ATCC 27029] Length=1171 Score = 1597 bits (4134), Expect = 0.0, Method: Compositional matrix adjust. Identities = 794/1180 (68%), Positives = 936/1180 (80%), Gaps = 16/1180 (1%) Query 13 LLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVLETIHRNYFEAGA 72 L D+L+ R+++ DGAMGT LQAADLTLDDF GLEGCNEILN TRPDV+ +H Y AGA Sbjct 5 LRDLLADRILIADGAMGTMLQAADLTLDDFDGLEGCNEILNVTRPDVVRGVHDAYLAAGA 64 Query 73 DAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRKRYVLGSMGPGTK 132 D VETNTFG NL NL +Y I RIR+LS+ G IAR AD + + R+VLGSMGPGTK Sbjct 65 DCVETNTFGANLPNLAEYGIPGRIRELSEAGARIAREAADAYATEEHPRFVLGSMGPGTK 124 Query 133 LPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLGSRRAMTRAGRHI 192 LPTLGH YA +RDAY E A G++ GGADA+++ETCQDLLQ+KAAV+GS+RA AGR + Sbjct 125 LPTLGHASYASLRDAYQENAAGLIAGGADALIIETCQDLLQVKAAVVGSKRARAEAGRDV 184 Query 193 PVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHARIP 252 P+ V VETTGTMLLGSEIGAALTA+EPLGVD+IGLNC+TGPAEM EHLR+L++H+RIP Sbjct 185 PIICQVAVETTGTMLLGSEIGAALTAIEPLGVDLIGLNCSTGPAEMGEHLRYLAQHSRIP 244 Query 253 VSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGTTPAHIREVAAAV 312 +SVMPNAGLPVL A GA +PL PDELA+AL F+ ++G++L+GGCCGTTP HIR + + Sbjct 245 ISVMPNAGLPVLTADGAYFPLSPDELADALEQFVTDYGVALIGGCCGTTPEHIRVLVERL 304 Query 313 ANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFREAMIAEDYQKCLD 372 R+ E VSS+Y +PF QDAS+L++GERTNANGSK FRE+M+A D+Q C++ Sbjct 305 GGRAPVAREPKPEAGVSSIYHHVPFVQDASILMVGERTNANGSKAFRESMLAGDWQACVE 364 Query 373 IAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDSTETAVLQAGLEHL 432 +A+ Q RDG+HLLDLCVDYVGRDG DM+ LA R AT+STLPI+LDSTE AV++AGLE L Sbjct 365 VARSQARDGSHLLDLCVDYVGRDGTQDMRELAGRFATASTLPIVLDSTEPAVIEAGLEML 424 Query 433 GGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQARTAQKKVEIAERLI 492 GGRC +NSVN+EDGDGP+SR+A+ M +V EHGAAVVAL IDEEGQART + KV +A RLI Sbjct 425 GGRCVVNSVNFEDGDGPDSRYARIMPVVREHGAAVVALLIDEEGQARTREWKVRVACRLI 484 Query 493 NDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRHPDVQTTLGLSNI 552 +D+TG WG+ ILID LTF IATGQEE+RRDGIETIEAIRE+ R+P V T G+SN+ Sbjct 485 DDLTGRWGMRREDILIDALTFPIATGQEETRRDGIETIEAIREIAARYPGVNFTAGISNV 544 Query 553 SFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNVALDLVYDRRRED 612 SFGLNPAARQVLNSVFLHEC +AGL SAIVHASKILPM RIP+EQR VALDLVYDRRRE Sbjct 545 SFGLNPAARQVLNSVFLHECAQAGLTSAIVHASKILPMARIPDEQREVALDLVYDRRREG 604 Query 613 YDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGLDADLDEAMTQ-K 671 YDP+Q + FEGV AAS++ R ELA LPL ERL +RI+DGERNGL+ADLD AM Q + Sbjct 605 YDPVQRFIEAFEGVDAASARATRAEELAALPLDERLKRRIIDGERNGLEADLDTAMAQGR 664 Query 672 PPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHMERSDDDSGKGR 731 PL IIN+ LL GMK VGELFGSGQMQLPFVLQSAEVMK AVAYLEPHME++DDD GKGR Sbjct 665 TPLSIINDLLLDGMKVVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHMEKTDDD-GKGR 723 Query 732 IVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKSADVVGMSGLLV 791 IVLATVKGDVHDIGKNLVDIILSNNGY+VVNIGIKQPI IL+ AE+ AD +GMSGLLV Sbjct 724 IVLATVKGDVHDIGKNLVDIILSNNGYDVVNIGIKQPINAILDAAEEHRADAIGMSGLLV 783 Query 792 KSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVHYARDAFEGLKL 851 KSTV+MKENL EM +RGVAE++PVLLGGAALTR+YVE+DL IY G+VHYARDAFEGL L Sbjct 784 KSTVIMKENLAEMASRGVAERWPVLLGGAALTRAYVEDDLRSIYPGQVHYARDAFEGLSL 843 Query 852 MDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEEPVEVPERSDVA 911 MD +M+AKRG AP + + A R +R ++ A R+A E + RSDVA Sbjct 844 MDRVMAAKRGGAP------MVDPEREAALAARRERRERQRAQVREALPELDDASVRSDVA 897 Query 912 ADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGPSYEDLVETEGR 971 D+ VP PPF+G+R+VKG+ +ADY LLDERA FLGQWGLRG RGG+GPSYE+LVETEGR Sbjct 898 VDVTVPKPPFFGTRVVKGVPLADYAALLDERATFLGQWGLRGARGGKGPSYEELVETEGR 957 Query 972 PRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGR 1031 PRLRYWLDRL +D +L AAVVYGYFPA SEGND+VVL E R RF FPRQ++ R Sbjct 958 PRLRYWLDRLISDQVL-EAAVVYGYFPAYSEGNDLVVLDENGHSE--RARFSFPRQRQER 1014 Query 1032 FLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQL 1091 LC+ADF R + ++DV+ QLVT+GQPI+++ ++FA N YRDYLEVHG+ VQL Sbjct 1015 RLCLADFFRPKG-----DQLDVVALQLVTVGQPISEYTAKMFAGNEYRDYLEVHGLSVQL 1069 Query 1092 TEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAK 1151 TEALAEYWHRRIR EL G +A EDP + YRG R+AFGY ACPDLEDRAK Sbjct 1070 TEALAEYWHRRIRAELVLPGGGTVADEDPADLAGLLRTDYRGCRYAFGYPACPDLEDRAK 1129 Query 1152 MMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFN 1191 ++ LL ERIGV LSEE QL PEQ+TDA V+HHPEA YFN Sbjct 1130 IVELLGAERIGVQLSEEFQLVPEQATDAIVVHHPEANYFN 1169 Lambda K H 0.317 0.135 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 3039930667170 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40