BLASTP 2.2.25+
Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
15,229,318 sequences; 5,219,829,388 total letters
Query= Rv2208
Length=249
Score E
Sequences producing significant alignments: (Bits) Value
gi|15609345|ref|NP_216724.1| cobalamin synthase [Mycobacterium t... 459 1e-127
gi|254365004|ref|ZP_04981050.1| cobalamin 5-phosphate synthase c... 458 2e-127
gi|31793387|ref|NP_855880.1| cobalamin synthase [Mycobacterium b... 457 9e-127
gi|340627213|ref|YP_004745665.1| putative cobalamin 5'-phosphate... 456 2e-126
gi|298525700|ref|ZP_07013109.1| cobalamin synthase [Mycobacteriu... 455 2e-126
gi|289447836|ref|ZP_06437580.1| cobalamin 5-phosphate synthase c... 453 9e-126
gi|167969399|ref|ZP_02551676.1| cobalamin synthase [Mycobacteriu... 416 2e-114
gi|294993593|ref|ZP_06799284.1| cobalamin synthase [Mycobacteriu... 405 2e-111
gi|289570324|ref|ZP_06450551.1| cobalamin 5-phosphate synthase c... 405 3e-111
gi|118618851|ref|YP_907183.1| cobalamin synthase [Mycobacterium ... 295 3e-78
gi|240168269|ref|ZP_04746928.1| cobalamin synthase [Mycobacteriu... 283 1e-74
gi|342859920|ref|ZP_08716573.1| cobalamin synthase [Mycobacteriu... 244 7e-63
gi|289750802|ref|ZP_06510180.1| cobalamin 5-phosphate synthase c... 244 1e-62
gi|315443874|ref|YP_004076753.1| cobalamin-5'-phosphate synthase... 231 1e-58
gi|145223528|ref|YP_001134206.1| cobalamin synthase [Mycobacteri... 229 3e-58
gi|120404543|ref|YP_954372.1| cobalamin synthase [Mycobacterium ... 225 4e-57
gi|169629039|ref|YP_001702688.1| cobalamin synthase [Mycobacteri... 222 4e-56
gi|108800272|ref|YP_640469.1| cobalamin synthase [Mycobacterium ... 221 5e-56
gi|126435895|ref|YP_001071586.1| cobalamin synthase [Mycobacteri... 221 9e-56
gi|41408047|ref|NP_960883.1| cobalamin synthase [Mycobacterium a... 219 3e-55
gi|336461933|gb|EGO40786.1| cobalamin-5-phosphate synthase [Myco... 219 3e-55
gi|118463547|ref|YP_881486.1| cobalamin synthase [Mycobacterium ... 216 2e-54
gi|118468361|ref|YP_888553.1| cobalamin synthase [Mycobacterium ... 210 2e-52
gi|333990335|ref|YP_004522949.1| cobalamin 5'-phosphate synthase... 196 3e-48
gi|312140200|ref|YP_004007536.1| cobalamin 5'-phosphate synthase... 177 1e-42
gi|226307097|ref|YP_002767057.1| cobalamin (5'-phosphate) syntha... 166 2e-39
gi|229490446|ref|ZP_04384287.1| cobalamin-5-phosphate synthase [... 163 2e-38
gi|296166081|ref|ZP_06848527.1| adenosylcobinamide-GDP ribazolet... 160 1e-37
gi|325676918|ref|ZP_08156590.1| adenosylcobinamide-GDP ribazolet... 157 2e-36
gi|333918938|ref|YP_004492519.1| cobalamin synthase [Amycolicico... 157 2e-36
gi|111018159|ref|YP_701131.1| cobalamin synthase [Rhodococcus jo... 155 7e-36
gi|226360287|ref|YP_002778065.1| cobalamin synthase [Rhodococcus... 154 2e-35
gi|262202960|ref|YP_003274168.1| cobalamin-5-phosphate synthase ... 150 2e-34
gi|296139245|ref|YP_003646488.1| cobalamin-5-phosphate synthase ... 145 5e-33
gi|54023667|ref|YP_117909.1| cobalamin synthase [Nocardia farcin... 140 1e-31
gi|256375495|ref|YP_003099155.1| cobalamin 5'-phosphate synthase... 139 5e-31
gi|134098232|ref|YP_001103893.1| putative cobalamin 5'-phosphate... 135 7e-30
gi|254774954|ref|ZP_05216470.1| cobalamin synthase [Mycobacteriu... 123 3e-26
gi|326382504|ref|ZP_08204195.1| cobalamin synthase [Gordonia neo... 120 2e-25
gi|331698326|ref|YP_004334565.1| Cobalamin synthase [Pseudonocar... 115 5e-24
gi|213966508|ref|ZP_03394677.1| cobalamin-5-phosphate synthase [... 114 1e-23
gi|343924155|ref|ZP_08763718.1| cobalamin synthase [Gordonia alk... 112 4e-23
gi|330469403|ref|YP_004407146.1| cobalamin-5-phosphate synthase ... 112 4e-23
gi|254822076|ref|ZP_05227077.1| cobalamin synthase [Mycobacteriu... 109 4e-22
gi|158313619|ref|YP_001506127.1| cobalamin 5'-phosphate synthase... 107 2e-21
gi|254774953|ref|ZP_05216469.1| cobalamin synthase [Mycobacteriu... 105 4e-21
gi|257054907|ref|YP_003132739.1| cobalamin-5-phosphate synthase ... 102 6e-20
gi|302529230|ref|ZP_07281572.1| cobalamin-5-phosphate synthase [... 101 1e-19
gi|159039086|ref|YP_001538339.1| cobalamin-5-phosphate synthase ... 98.6 7e-19
gi|258650432|ref|YP_003199588.1| cobalamin-5-phosphate synthase ... 98.6 7e-19
>gi|15609345|ref|NP_216724.1| cobalamin synthase [Mycobacterium tuberculosis H37Rv]
gi|15841699|ref|NP_336736.1| cobalamin synthase [Mycobacterium tuberculosis CDC1551]
gi|148662025|ref|YP_001283548.1| cobalamin synthase [Mycobacterium tuberculosis H37Ra]
45 more sequence titles
Length=249
Score = 459 bits (1182), Expect = 1e-127, Method: Compositional matrix adjust.
Identities = 248/249 (99%), Positives = 249/249 (100%), Gaps = 0/249 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP
Sbjct 1 MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA
Sbjct 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW
Sbjct 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA
Sbjct 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
Query 241 VTLAGLARL 249
VTLAGLARL
Sbjct 241 VTLAGLARL 249
>gi|254365004|ref|ZP_04981050.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
str. Haarlem]
gi|289554005|ref|ZP_06443215.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
KZN 605]
gi|134150518|gb|EBA42563.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
str. Haarlem]
gi|289438637|gb|EFD21130.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
KZN 605]
gi|328458490|gb|AEB03913.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
KZN 4207]
gi|339295122|gb|AEJ47233.1| cobalamin synthase [Mycobacterium tuberculosis CCDC5079]
Length=248
Score = 458 bits (1179), Expect = 2e-127, Method: Compositional matrix adjust.
Identities = 248/248 (100%), Positives = 248/248 (100%), Gaps = 0/248 (0%)
Query 2 MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL 61
MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL
Sbjct 1 MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL 60
Query 62 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 121
SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL
Sbjct 61 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 120
Query 122 QGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
QGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL
Sbjct 121 QGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 180
Query 182 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV
Sbjct 181 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 240
Query 242 TLAGLARL 249
TLAGLARL
Sbjct 241 TLAGLARL 248
>gi|31793387|ref|NP_855880.1| cobalamin synthase [Mycobacterium bovis AF2122/97]
gi|121638089|ref|YP_978313.1| cobalamin synthase [Mycobacterium bovis BCG str. Pasteur 1173P2]
gi|224990583|ref|YP_002645270.1| cobalamin synthase [Mycobacterium bovis BCG str. Tokyo 172]
15 more sequence titles
Length=249
Score = 457 bits (1175), Expect = 9e-127, Method: Compositional matrix adjust.
Identities = 247/249 (99%), Positives = 248/249 (99%), Gaps = 0/249 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP
Sbjct 1 MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA
Sbjct 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRR VPAAHGSTLGSRVAGTQPAPVVAAW
Sbjct 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAW 180
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA
Sbjct 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
Query 241 VTLAGLARL 249
VTLAGLARL
Sbjct 241 VTLAGLARL 249
>gi|340627213|ref|YP_004745665.1| putative cobalamin 5'-phosphate synthase CobS [Mycobacterium
canettii CIPT 140010059]
gi|340005403|emb|CCC44562.1| putative cobalamin 5'-phosphate synthase CobS [Mycobacterium
canettii CIPT 140010059]
Length=249
Score = 456 bits (1172), Expect = 2e-126, Method: Compositional matrix adjust.
Identities = 246/249 (99%), Positives = 248/249 (99%), Gaps = 0/249 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP
Sbjct 1 MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA
Sbjct 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRR VPAAHGSTLGSRVAGTQPAPVVAAW
Sbjct 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAW 180
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
LAVLLAVSVPAGPRPWQGPIAVL+AVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA
Sbjct 181 LAVLLAVSVPAGPRPWQGPIAVLLAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
Query 241 VTLAGLARL 249
VTLAGLARL
Sbjct 241 VTLAGLARL 249
>gi|298525700|ref|ZP_07013109.1| cobalamin synthase [Mycobacterium tuberculosis 94_M4241A]
gi|298495494|gb|EFI30788.1| cobalamin synthase [Mycobacterium tuberculosis 94_M4241A]
Length=248
Score = 455 bits (1171), Expect = 2e-126, Method: Compositional matrix adjust.
Identities = 247/248 (99%), Positives = 247/248 (99%), Gaps = 0/248 (0%)
Query 2 MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL 61
MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL
Sbjct 1 MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL 60
Query 62 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 121
SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL
Sbjct 61 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 120
Query 122 QGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
QGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL
Sbjct 121 QGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 180
Query 182 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAH VHRFGGVTGDVLGSAIELSTTVSAV
Sbjct 181 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHYVHRFGGVTGDVLGSAIELSTTVSAV 240
Query 242 TLAGLARL 249
TLAGLARL
Sbjct 241 TLAGLARL 248
>gi|289447836|ref|ZP_06437580.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
CPHL_A]
gi|289420794|gb|EFD17995.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
CPHL_A]
Length=249
Score = 453 bits (1166), Expect = 9e-126, Method: Compositional matrix adjust.
Identities = 246/249 (99%), Positives = 247/249 (99%), Gaps = 0/249 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP
Sbjct 1 MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
LSGM TVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA
Sbjct 61 LSGMPTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRR VPAAHGSTLGSRVAGTQPAPVVAAW
Sbjct 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAW 180
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA
Sbjct 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
Query 241 VTLAGLARL 249
VTLAGLARL
Sbjct 241 VTLAGLARL 249
>gi|167969399|ref|ZP_02551676.1| cobalamin synthase [Mycobacterium tuberculosis H37Ra]
Length=225
Score = 416 bits (1068), Expect = 2e-114, Method: Compositional matrix adjust.
Identities = 225/225 (100%), Positives = 225/225 (100%), Gaps = 0/225 (0%)
Query 25 MGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVAD 84
MGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVAD
Sbjct 1 MGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVAD 60
Query 85 TADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSG 144
TADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSG
Sbjct 61 TADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSG 120
Query 145 RVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLV 204
RVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLV
Sbjct 121 RVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLV 180
Query 205 AVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 249
AVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL
Sbjct 181 AVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 225
>gi|294993593|ref|ZP_06799284.1| cobalamin synthase [Mycobacterium tuberculosis 210]
gi|297634797|ref|ZP_06952577.1| cobalamin synthase [Mycobacterium tuberculosis KZN 4207]
gi|297731788|ref|ZP_06960906.1| cobalamin synthase [Mycobacterium tuberculosis KZN R506]
Length=220
Score = 405 bits (1042), Expect = 2e-111, Method: Compositional matrix adjust.
Identities = 220/220 (100%), Positives = 220/220 (100%), Gaps = 0/220 (0%)
Query 30 MTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGL 89
MTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGL
Sbjct 1 MTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGL 60
Query 90 GCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAV 149
GCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAV
Sbjct 61 GCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAV 120
Query 150 LVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAG 209
LVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAG
Sbjct 121 LVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAG 180
Query 210 AALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 249
AALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL
Sbjct 181 AALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 220
>gi|289570324|ref|ZP_06450551.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
T17]
gi|289544078|gb|EFD47726.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
T17]
Length=223
Score = 405 bits (1041), Expect = 3e-111, Method: Compositional matrix adjust.
Identities = 220/221 (99%), Positives = 220/221 (99%), Gaps = 0/221 (0%)
Query 29 PMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADG 88
PMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADG
Sbjct 3 PMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADG 62
Query 89 LGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTA 148
LGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTA
Sbjct 63 LGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTA 122
Query 149 VLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTA 208
VLVCRR VPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTA
Sbjct 123 VLVCRRSVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTA 182
Query 209 GAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 249
GAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL
Sbjct 183 GAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 223
>gi|118618851|ref|YP_907183.1| cobalamin synthase [Mycobacterium ulcerans Agy99]
gi|183983244|ref|YP_001851535.1| cobalamin 5'-phosphate synthase CobS [Mycobacterium marinum M]
gi|166217402|sp|A0PTP3.1|COBS_MYCUA RecName: Full=Cobalamin synthase
gi|226709140|sp|B2HGX7.1|COBS_MYCMM RecName: Full=Cobalamin synthase
gi|118570961|gb|ABL05712.1| cobalamin 5'-phosphate synthase CobS [Mycobacterium ulcerans
Agy99]
gi|183176570|gb|ACC41680.1| cobalamin 5'-phosphate synthase CobS [Mycobacterium marinum M]
Length=252
Score = 295 bits (756), Expect = 3e-78, Method: Compositional matrix adjust.
Identities = 182/252 (73%), Positives = 203/252 (81%), Gaps = 3/252 (1%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++RSLATA +F TVIP P S PMGRG MTALPVVG LG LAA + W+ + VFGP SP
Sbjct 1 MIRSLATALSFGTVIPVPASVAAPMGRGAMTALPVVGVVLGGLAAGVTWSASLVFGPVSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L G+L VAVLL+ TRGLHID VADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA
Sbjct 61 LPGLLAVAVLLLATRGLHIDAVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
Query 121 LQGLAFATLT---TVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVV 177
+QG AF+TL+ + GIAGI +AV +GRVTAVL CRR VPAA GS+LGSRVAGTQP V+
Sbjct 121 VQGSAFSTLSAAGSRGIAGIAVAVFAGRVTAVLGCRRSVPAAAGSSLGSRVAGTQPISVL 180
Query 178 AAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTT 237
AWLAVLL S+ A PRPWQGP AV+ AV AG L HCV RFGG+TGDVLG AIEL+TT
Sbjct 181 VAWLAVLLFASLAAAPRPWQGPAAVVAAVCAGTLLIRHCVRRFGGITGDVLGCAIELATT 240
Query 238 VSAVTLAGLARL 249
V+AV LA L RL
Sbjct 241 VTAVVLAALVRL 252
>gi|240168269|ref|ZP_04746928.1| cobalamin synthase [Mycobacterium kansasii ATCC 12478]
Length=246
Score = 283 bits (725), Expect = 1e-74, Method: Compositional matrix adjust.
Identities = 181/238 (77%), Positives = 199/238 (84%), Gaps = 3/238 (1%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++RSLATAFAF TV+ P S T PMGRG MTALPVVGAALG +AA + WAGA VFGPSSP
Sbjct 1 MIRSLATAFAFGTVMRMPSSQTAPMGRGAMTALPVVGAALGGVAAGVTWAGAVVFGPSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
LSG+L V VLL TRGLHIDGVADTADGLGCYGP QRALAVMRDGS+GPFGVAAVVLVI
Sbjct 61 LSGLLAVTVLLAATRGLHIDGVADTADGLGCYGPAQRALAVMRDGSSGPFGVAAVVLVIT 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
LQGLAF L AG+ +AV +GR+TAVL CRR VPAA GS LG+RVA TQPA VVAAW
Sbjct 121 LQGLAFPALGA---AGVVVAVFAGRITAVLACRRSVPAAEGSVLGARVADTQPAAVVAAW 177
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
LAVL+A S+PAGPRPW GP+AVLVAV GAAL HCV RFGGVTGDV+G+AIEL+TTV
Sbjct 178 LAVLVAASLPAGPRPWHGPVAVLVAVLCGAALVTHCVRRFGGVTGDVIGAAIELTTTV 235
>gi|342859920|ref|ZP_08716573.1| cobalamin synthase [Mycobacterium colombiense CECT 3035]
gi|342133052|gb|EGT86272.1| cobalamin synthase [Mycobacterium colombiense CECT 3035]
Length=252
Score = 244 bits (624), Expect = 7e-63, Method: Compositional matrix adjust.
Identities = 178/254 (71%), Positives = 202/254 (80%), Gaps = 7/254 (2%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++RSLATAFAF TV+P PG+A PMGRG MTALPVVGAALGALAAA+ W G VFG SSP
Sbjct 1 MIRSLATAFAFGTVLPVPGNA--PMGRGAMTALPVVGAALGALAAAVTWGGGWVFGRSSP 58
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L G+L VAVLL+ TRGLH+DG+ADTADGLGCYGPPQRALAVMR+G+ GPFGVAAVV+VI
Sbjct 59 LPGLLAVAVLLLATRGLHVDGLADTADGLGCYGPPQRALAVMREGAAGPFGVAAVVVVIM 118
Query 121 LQGLAFATLTTVG-----IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAP 175
LQ LAF+ L G +A + +AV +GRV AVL R VPAA GS LG RVAGTQP
Sbjct 119 LQALAFSALGATGRVVPGVAAVAVAVFAGRVAAVLAGHRSVPAADGSALGVRVAGTQPTL 178
Query 176 VVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELS 235
VVAAW+AVLLA SVPAG RPWQGP AVL+ + GA L HCV RFGG+TGDVLG+AIEL+
Sbjct 179 VVAAWVAVLLAASVPAGSRPWQGPAAVLLGLGCGAVLVRHCVRRFGGITGDVLGAAIELT 238
Query 236 TTVSAVTLAGLARL 249
TTV+AV LAG R
Sbjct 239 TTVTAVLLAGAVRF 252
>gi|289750802|ref|ZP_06510180.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
T92]
gi|289691389|gb|EFD58818.1| cobalamin 5-phosphate synthase cobS [Mycobacterium tuberculosis
T92]
Length=225
Score = 244 bits (622), Expect = 1e-62, Method: Compositional matrix adjust.
Identities = 152/165 (93%), Positives = 153/165 (93%), Gaps = 0/165 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP
Sbjct 1 MMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA
Sbjct 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLG 165
LQGLAFATLTTVGIAGITLAVLSGRVT PAAHG G
Sbjct 121 LQGLAFATLTTVGIAGITLAVLSGRVTPYWSVAGRCPAAHGQHPG 165
>gi|315443874|ref|YP_004076753.1| cobalamin-5'-phosphate synthase [Mycobacterium sp. Spyr1]
gi|315262177|gb|ADT98918.1| cobalamin-5'-phosphate synthase [Mycobacterium sp. Spyr1]
Length=247
Score = 231 bits (588), Expect = 1e-58, Method: Compositional matrix adjust.
Identities = 145/244 (60%), Positives = 178/244 (73%), Gaps = 3/244 (1%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
V RSLA AFAFATV+P P GRG +TALPVVG LG+ AAA+ W G + FG S
Sbjct 5 VTRSLAGAFAFATVMPVPSRRAAIAGRGVLTALPVVGLVLGSAAAAVCWLGTRAFGSGSV 64
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L+G LTVAVLL+ TRGLHIDG++DT D LGCYGP +RALAVMRDG GPFGVAAV + +
Sbjct 65 LAGALTVAVLLLATRGLHIDGLSDTTDALGCYGPAERALAVMRDGRAGPFGVAAVAVTVV 124
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
+Q +AF + G A + +AV +GRV V+ CRR VPAA GSTLG+ VAGTQP V AAW
Sbjct 125 IQSVAF---SQAGWAAVLVAVAAGRVAVVVACRRGVPAAEGSTLGALVAGTQPLWVAAAW 181
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
L + ++ AG R WQGP+AV+VAV + AHCV RFGG+TGDVLG+A+E++TTV+A
Sbjct 182 LVAIAGLATLAGERAWQGPLAVVVAVACSVVMVAHCVRRFGGITGDVLGAAVEVTTTVTA 241
Query 241 VTLA 244
+ LA
Sbjct 242 LGLA 245
>gi|145223528|ref|YP_001134206.1| cobalamin synthase [Mycobacterium gilvum PYR-GCK]
gi|189082632|sp|A4TBJ8.1|COBS_MYCGI RecName: Full=Cobalamin synthase
gi|145216014|gb|ABP45418.1| cobalamin-5'-phosphate synthase [Mycobacterium gilvum PYR-GCK]
Length=243
Score = 229 bits (584), Expect = 3e-58, Method: Compositional matrix adjust.
Identities = 144/242 (60%), Positives = 177/242 (74%), Gaps = 3/242 (1%)
Query 3 RSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLS 62
RSLA AFAFATV+P P GRG +TALPVVG LG+ AAA+ W G + FG S L+
Sbjct 3 RSLAGAFAFATVMPVPSRRAAIAGRGVLTALPVVGLVLGSAAAAVCWLGTRAFGSGSVLA 62
Query 63 GMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQ 122
G LTVAVLL+ TRGLHIDG++DT D LGCYGP +RALAVMRDG GPFGVAAV + + +Q
Sbjct 63 GALTVAVLLLATRGLHIDGLSDTTDALGCYGPAERALAVMRDGRAGPFGVAAVAVTVVIQ 122
Query 123 GLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLA 182
+AF + G A + +AV +GRV V+ CRR VPAA GSTLG+ VAGTQP V AAWL
Sbjct 123 SVAF---SQAGWAAVLVAVAAGRVAVVVACRRGVPAAEGSTLGALVAGTQPLWVAAAWLV 179
Query 183 VLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVT 242
+ ++ AG R WQGP+AV+VAV + AHCV RFGG+TGDVLG+A+E++TTV+A+
Sbjct 180 AIAGLATLAGERAWQGPLAVVVAVACSVVMVAHCVRRFGGITGDVLGAAVEVTTTVTALG 239
Query 243 LA 244
LA
Sbjct 240 LA 241
>gi|120404543|ref|YP_954372.1| cobalamin synthase [Mycobacterium vanbaalenii PYR-1]
gi|166217403|sp|A1TB16.1|COBS_MYCVP RecName: Full=Cobalamin synthase
gi|119957361|gb|ABM14366.1| cobalamin-5'-phosphate synthase [Mycobacterium vanbaalenii PYR-1]
Length=243
Score = 225 bits (574), Expect = 4e-57, Method: Compositional matrix adjust.
Identities = 148/244 (61%), Positives = 182/244 (75%), Gaps = 3/244 (1%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++ SL AFAFATV+PTP AT +GRG +TALPV GAALG LAA + WAG+ FG S
Sbjct 1 MISSLTGAFAFATVLPTPTRATAMVGRGVLTALPVAGAALGVLAAGVLWAGSWAFGDGSA 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L+G+LTVAVLL+ TRGLHIDG++DT D LGCYGPP+RALAVMRDG+ GPFGVAAV +
Sbjct 61 LAGVLTVAVLLLATRGLHIDGLSDTVDALGCYGPPERALAVMRDGTAGPFGVAAVAATLL 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
+Q LAFA G A + +AV++GRV V CRR VPAA GSTLG+ V+GTQP V A W
Sbjct 121 VQSLAFA---QSGWAAVFIAVVAGRVAVVAACRRGVPAAAGSTLGALVSGTQPRWVAAGW 177
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
+ A +VP RPWQGP+ V +A+ A L AHCV RFGG+TGDVLG+A+E++TT++A
Sbjct 178 TVAVAAAAVPVCARPWQGPLVVALALACSAGLVAHCVRRFGGITGDVLGAALEVTTTIAA 237
Query 241 VTLA 244
V LA
Sbjct 238 VGLA 241
>gi|169629039|ref|YP_001702688.1| cobalamin synthase [Mycobacterium abscessus ATCC 19977]
gi|169241006|emb|CAM62034.1| Cobalamin synthase CobS [Mycobacterium abscessus]
Length=252
Score = 222 bits (565), Expect = 4e-56, Method: Compositional matrix adjust.
Identities = 125/246 (51%), Positives = 166/246 (68%), Gaps = 4/246 (1%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++R + AF FATV P P + + ALPVVGAALG LAA +AW F +P
Sbjct 7 ILRPVGGAFEFATVAPVPARLAGTLSGPVLGALPVVGAALGVLAAFVAWV--MHFAYMAP 64
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
++G+ VA ++ TRGLHIDG++DTADGLGCYGPP+RAL VMRDGS GPFGV +++ +
Sbjct 65 IAGLAAVAATILATRGLHIDGLSDTADGLGCYGPPERALTVMRDGSAGPFGVVVLIICLL 124
Query 121 LQGLAFATL-TTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAA 179
Q L+F L + + LA+ GR++AV+ CRR VP A S G+RVAG+QP +
Sbjct 125 AQALSFGVLASRQEWLAVALAITVGRISAVVACRRGVPGAAASGFGTRVAGSQPLWLAGM 184
Query 180 WLAVLLAVSVPAGP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
W+A +AV + A RPWQGP+ V VA+ AGA L HCV RFGG+TGDVLG++IE++TTV
Sbjct 185 WVAAAMAVGLLAQTWRPWQGPVVVAVALIAGALLVRHCVRRFGGITGDVLGASIEITTTV 244
Query 239 SAVTLA 244
+A+ A
Sbjct 245 AALGFA 250
>gi|108800272|ref|YP_640469.1| cobalamin synthase [Mycobacterium sp. MCS]
gi|119869400|ref|YP_939352.1| cobalamin synthase [Mycobacterium sp. KMS]
gi|123069978|sp|Q1B6S1.1|COBS_MYCSS RecName: Full=Cobalamin synthase
gi|166217400|sp|A1UIA4.1|COBS_MYCSK RecName: Full=Cobalamin synthase
gi|108770691|gb|ABG09413.1| cobalamin-5'-phosphate synthase [Mycobacterium sp. MCS]
gi|119695489|gb|ABL92562.1| cobalamin-5'-phosphate synthase [Mycobacterium sp. KMS]
Length=248
Score = 221 bits (564), Expect = 5e-56, Method: Compositional matrix adjust.
Identities = 146/242 (61%), Positives = 180/242 (75%), Gaps = 2/242 (0%)
Query 4 SLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSG 63
SLA AFAF TV+P P +T +GRG MTALP VG LGA+AAA+ WAG+ FGP S L+G
Sbjct 4 SLAGAFAFGTVLPVPAGSTATLGRGVMTALPGVGIVLGAVAAAVLWAGSWAFGPHSALAG 63
Query 64 MLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQG 123
+L VAVLL+ TRG+HIDG++DT DGLGCYG P+RAL VMRDGS G FG A++V+ + Q
Sbjct 64 LLAVAVLLLATRGMHIDGLSDTVDGLGCYGAPERALRVMRDGSAGAFGAASIVVAVGAQT 123
Query 124 LAFATL--TTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
LAF+ L G G+ +AV +GRV A++ CRR +PAA GS LG RVAGTQPA VV WL
Sbjct 124 LAFSMLPGGWSGAVGVVVAVTAGRVAALVACRRGIPAAEGSALGGRVAGTQPAAVVLVWL 183
Query 182 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
A + A+++PA R WQGP+ V+VAV A L HCV RFGG+TGDVLG+AIE++TTV AV
Sbjct 184 AAVAALAIPATERIWQGPLTVVVAVGMTALLVRHCVRRFGGITGDVLGAAIEVTTTVVAV 243
Query 242 TL 243
L
Sbjct 244 GL 245
>gi|126435895|ref|YP_001071586.1| cobalamin synthase [Mycobacterium sp. JLS]
gi|166217399|sp|A3Q1R8.1|COBS_MYCSJ RecName: Full=Cobalamin synthase
gi|126235695|gb|ABN99095.1| cobalamin-5'-phosphate synthase [Mycobacterium sp. JLS]
Length=248
Score = 221 bits (562), Expect = 9e-56, Method: Compositional matrix adjust.
Identities = 146/242 (61%), Positives = 180/242 (75%), Gaps = 2/242 (0%)
Query 4 SLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSG 63
SLA AFAF TV+P P +T +GRG MTALP VG LGA+AAA+ WAG+ FGP S L+G
Sbjct 4 SLAGAFAFGTVLPVPTGSTATLGRGVMTALPGVGIVLGAVAAAVLWAGSWAFGPHSALAG 63
Query 64 MLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQG 123
+L VAVLL+ TRG+HIDG++DT DGLGCYG P+RAL VMRDGS G FG A++V+ + Q
Sbjct 64 LLAVAVLLLATRGMHIDGLSDTVDGLGCYGAPERALRVMRDGSAGAFGAASIVVAVGAQT 123
Query 124 LAFATL--TTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
LAF+ L G G+ +AV +GRV A++ CRR +PAA GS LG RVAGTQPA VV WL
Sbjct 124 LAFSMLPGGWSGAVGVVVAVTAGRVAALVACRRGIPAAEGSALGGRVAGTQPAAVVLVWL 183
Query 182 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
A + A+++PA R WQGP+ V+VAV A L HCV RFGG+TGDVLG+AIE++TTV AV
Sbjct 184 AAVAALAIPATERIWQGPLTVVVAVGMTALLVRHCVRRFGGITGDVLGAAIEVTTTVVAV 243
Query 242 TL 243
L
Sbjct 244 GL 245
>gi|41408047|ref|NP_960883.1| cobalamin synthase [Mycobacterium avium subsp. paratuberculosis
K-10]
gi|81571294|sp|Q73YK6.1|COBS_MYCPA RecName: Full=Cobalamin synthase
gi|41396402|gb|AAS04266.1| CobS [Mycobacterium avium subsp. paratuberculosis K-10]
Length=251
Score = 219 bits (558), Expect = 3e-55, Method: Compositional matrix adjust.
Identities = 172/251 (69%), Positives = 198/251 (79%), Gaps = 2/251 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAF TV+P P PMGRG MTALPVVG ALGALAAA+AW GA VFG SSP
Sbjct 1 MMRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L G+L VA LL++TRGLHIDGVADTADGLGCYGPP RA AVMRDGSTGPFGVAAVV+V+
Sbjct 61 LGGLLAVAALLLITRGLHIDGVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVM 120
Query 121 LQGLAFATLT--TVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVA 178
Q LAF+ L G+ +AV +GRV AVL CRR VPAA GS+LG+ VAG+QPA V A
Sbjct 121 AQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPAAAGSSLGATVAGSQPATVAA 180
Query 179 AWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
AW+AVLL +S+ AGPRPW GP+AVL+ + G L HCV RFGG++GDVLG+AIEL+ TV
Sbjct 181 AWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATV 240
Query 239 SAVTLAGLARL 249
SAV LA L R+
Sbjct 241 SAVALAALVRV 251
>gi|336461933|gb|EGO40786.1| cobalamin-5-phosphate synthase [Mycobacterium avium subsp. paratuberculosis
S397]
Length=250
Score = 219 bits (557), Expect = 3e-55, Method: Compositional matrix adjust.
Identities = 172/250 (69%), Positives = 197/250 (79%), Gaps = 2/250 (0%)
Query 2 MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL 61
MRSLATAFAF TV+P P PMGRG MTALPVVG ALGALAAA+AW GA VFG SSPL
Sbjct 1 MRSLATAFAFGTVLPVPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGAVVFGRSSPL 60
Query 62 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 121
G+L VA LL++TRGLHIDGVADTADGLGCYGPP RA AVMRDGSTGPFGVAAVV+V+
Sbjct 61 GGLLAVAALLLITRGLHIDGVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVMA 120
Query 122 QGLAFATLT--TVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAA 179
Q LAF+ L G+ +AV +GRV AVL CRR VPAA GS+LG+ VAG+QPA V AA
Sbjct 121 QALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPAAAGSSLGATVAGSQPATVAAA 180
Query 180 WLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVS 239
W+AVLL +S+ AGPRPW GP+AVL+ + G L HCV RFGG++GDVLG+AIEL+ TVS
Sbjct 181 WVAVLLGMSLVAGPRPWHGPVAVLLGLGCGGVLVRHCVRRFGGISGDVLGAAIELTATVS 240
Query 240 AVTLAGLARL 249
AV LA L R+
Sbjct 241 AVALAALVRV 250
>gi|118463547|ref|YP_881486.1| cobalamin synthase [Mycobacterium avium 104]
gi|166217396|sp|A0QEZ8.1|COBS_MYCA1 RecName: Full=Cobalamin synthase
gi|118164834|gb|ABK65731.1| cobalamin-5-phosphate synthase [Mycobacterium avium 104]
Length=251
Score = 216 bits (551), Expect = 2e-54, Method: Compositional matrix adjust.
Identities = 172/251 (69%), Positives = 198/251 (79%), Gaps = 2/251 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
+MRSLATAFAF TV+P P PMGRG MTALPVVG ALGALAAA+AW G VFG SSP
Sbjct 1 MMRSLATAFAFGTVLPMPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGTVVFGRSSP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L G+L VA LL++TRGLHIDGVADTADGLGCYGPP RA AVMRDGSTGPFGVAAVV+V+
Sbjct 61 LGGLLAVAALLLITRGLHIDGVADTADGLGCYGPPDRARAVMRDGSTGPFGVAAVVVVVM 120
Query 121 LQGLAFATLT--TVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVA 178
Q LAF+ L G+ +AV +GRV AVL CRR VPAA GS+LG+ VAG+QPA V A
Sbjct 121 AQALAFSALAAGRPVPVGVAVAVFAGRVAAVLACRRTVPAAAGSSLGAAVAGSQPATVAA 180
Query 179 AWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
AW+AVLL +S+ AGPRPW GP+AVL+ + GA L HCV RFGG++GDVLG+AIEL+ TV
Sbjct 181 AWVAVLLGMSLVAGPRPWHGPVAVLLGLGCGAVLVRHCVRRFGGISGDVLGAAIELTATV 240
Query 239 SAVTLAGLARL 249
SAV LA L R+
Sbjct 241 SAVALAALVRV 251
>gi|118468361|ref|YP_888553.1| cobalamin synthase [Mycobacterium smegmatis str. MC2 155]
gi|166217398|sp|A0R065.1|COBS_MYCS2 RecName: Full=Cobalamin synthase
gi|118169648|gb|ABK70544.1| cobalamin 5'-phosphate synthase [Mycobacterium smegmatis str.
MC2 155]
Length=241
Score = 210 bits (535), Expect = 2e-52, Method: Compositional matrix adjust.
Identities = 152/244 (63%), Positives = 182/244 (75%), Gaps = 5/244 (2%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++RSLA AFAF TV+P SA +GRG +TALP VG ALGALAAA+ WAG F SP
Sbjct 1 MIRSLAGAFAFGTVLPVRASAG--VGRGALTALPFVGLALGALAAAVVWAGGWAFAAGSP 58
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L G+L VAVLL+ TRGLHIDG DT DGLGCYGPP+RALAVMRDGS GPFGVAAVV+VIA
Sbjct 59 LPGVLAVAVLLLATRGLHIDGFCDTVDGLGCYGPPERALAVMRDGSAGPFGVAAVVVVIA 118
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
+Q L FA L+ + + +A V CRR VPAA GSTLG+ VAG+QP VVA W
Sbjct 119 VQALTFAELSVLAVVTAVVAGRV---AVVAACRRSVPAAAGSTLGAAVAGSQPRWVVAGW 175
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
+ L A++V A PRPWQGP+AVLVA+ AL AHCV RFGG+TGDVLG+A+E++TT++A
Sbjct 176 IVALAALAVFACPRPWQGPLAVLVAIGCSLALVAHCVRRFGGITGDVLGAAVEVTTTLAA 235
Query 241 VTLA 244
+ LA
Sbjct 236 LGLA 239
>gi|333990335|ref|YP_004522949.1| cobalamin 5'-phosphate synthase CobS [Mycobacterium sp. JDM601]
gi|333486303|gb|AEF35695.1| cobalamin 5'-phosphate synthase CobS [Mycobacterium sp. JDM601]
Length=243
Score = 196 bits (498), Expect = 3e-48, Method: Compositional matrix adjust.
Identities = 146/236 (62%), Positives = 168/236 (72%), Gaps = 3/236 (1%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++RSLA+A F T P + GRG +TALPVVGA LGALAA W G FGP S
Sbjct 1 MIRSLASAITFGTAARLPAATGGVPGRGTLTALPVVGAGLGALAAGAVWTGGFAFGPGSA 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
++G+L VAVLL TRGLHIDGVADTADGLGCY P ++AL VMRDG+TGPFGV AVVLV+
Sbjct 61 VTGLLAVAVLLAATRGLHIDGVADTADGLGCYRPAEQALQVMRDGATGPFGVVAVVLVVG 120
Query 121 LQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
LQ AF L T AGI +AV +GRV AVL C R VPAA GSTLG+ VAG+QP PV AW
Sbjct 121 LQASAFPMLDT---AGIVVAVCAGRVAAVLACLRSVPAAPGSTLGAAVAGSQPVPVAIAW 177
Query 181 LAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELST 236
+AVL A S AG PW GP+AV VA+ A L HCV R GGVTGDVLG+A+E +T
Sbjct 178 VAVLAAGSTLAGAAPWHGPVAVAVALVGAAVLVRHCVRRLGGVTGDVLGAAVEWTT 233
>gi|312140200|ref|YP_004007536.1| cobalamin 5'-phosphate synthase cobs [Rhodococcus equi 103S]
gi|311889539|emb|CBH48856.1| cobalamin 5'-phosphate synthase CobS [Rhodococcus equi 103S]
Length=253
Score = 177 bits (449), Expect = 1e-42, Method: Compositional matrix adjust.
Identities = 118/242 (49%), Positives = 154/242 (64%), Gaps = 7/242 (2%)
Query 5 LATAFAFATVIPT--PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP-L 61
L+TA ++ TV+P P GR + A PVVGA LGA A A+ W V+ P L
Sbjct 8 LSTALSWLTVLPVRGPREIGRAEGRAAIGAAPVVGALLGAGAVAVLWV--LVWAGLDPAL 65
Query 62 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 121
+G+LTV L V TRG+H+DG+ADTADGLGCYGPP+RA VMR G GPFGVAA+++ I +
Sbjct 66 AGLLTVGALAVSTRGMHVDGLADTADGLGCYGPPERAREVMRSGGAGPFGVAALIVTIGV 125
Query 122 QGLAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAW 180
Q LA+ +L G + +AV +GRV+AV CRR +PA+ S G+ VA +QPA A W
Sbjct 126 QALAYGSLGAGGAWIAVAVAVATGRVSAVFACRRGIPASSPSGFGALVADSQPAWTAAVW 185
Query 181 LAVLLAVSVPAGP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVS 239
A ++ A P R WQGP+ ++VA+T L HCV RF GV GDVLG+AIE + +
Sbjct 186 GAAAAVAALWAVPDRWWQGPLVIVVALTGAILLVRHCVRRFAGVNGDVLGAAIEFTVAAT 245
Query 240 AV 241
AV
Sbjct 246 AV 247
>gi|226307097|ref|YP_002767057.1| cobalamin (5'-phosphate) synthase [Rhodococcus erythropolis PR4]
gi|226186214|dbj|BAH34318.1| cobalamin (5'-phosphate) synthase [Rhodococcus erythropolis PR4]
Length=255
Score = 166 bits (421), Expect = 2e-39, Method: Compositional matrix adjust.
Identities = 103/242 (43%), Positives = 137/242 (57%), Gaps = 7/242 (2%)
Query 8 AFAFATVIPT--PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGML 65
AF++ TV+P P GR + A P+ G ALG A + W G G + L+G+L
Sbjct 11 AFSWLTVLPVRGPSDIDRTAGRRAIAAAPLTGIALGIAATFLLW-GTTSIGLNPYLAGLL 69
Query 66 TVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLA 125
TV L + TRG+H+DG+AD+ DGLGCYGPP+RA VM G GPFGVAA+ + + LQ ++
Sbjct 70 TVGALALATRGMHVDGLADSVDGLGCYGPPERAREVMHSGGAGPFGVAALFIFLGLQSVS 129
Query 126 FATLTTVGIAGITLAVL----SGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
F L +AVL +GRV V CRR + A+ S G+ VA +QP W
Sbjct 130 FGVLAVADSPTQWIAVLVSVAAGRVAVVFACRRGILASSPSGFGALVADSQPLWAAIVWS 189
Query 182 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
L+A S A R W GP+ A+ HCV RFGG+ GDVLG A+EL+ T++AV
Sbjct 190 VPLIATSAFATDRWWLGPLVTASALVISVLCVRHCVRRFGGLNGDVLGFALELTVTLTAV 249
Query 242 TL 243
L
Sbjct 250 GL 251
>gi|229490446|ref|ZP_04384287.1| cobalamin-5-phosphate synthase [Rhodococcus erythropolis SK121]
gi|229322736|gb|EEN88516.1| cobalamin-5-phosphate synthase [Rhodococcus erythropolis SK121]
Length=255
Score = 163 bits (412), Expect = 2e-38, Method: Compositional matrix adjust.
Identities = 103/242 (43%), Positives = 137/242 (57%), Gaps = 7/242 (2%)
Query 8 AFAFATVIP--TPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGML 65
AF++ TV+P P GR + A P+ G ALG A + W G G + L+G+L
Sbjct 11 AFSWLTVLPVRDPSDIDRTAGRRAIAAAPLTGIALGIAATFLLW-GTTSIGLNPYLAGLL 69
Query 66 TVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLA 125
TV L + TRG+H+DG+AD+ DGLGCYGPP+RA VM G GPFGVAA+ + + LQ ++
Sbjct 70 TVGALALGTRGMHVDGLADSVDGLGCYGPPERAREVMHSGGAGPFGVAALFIFLGLQSVS 129
Query 126 FATLTTVGIAGITLAVL----SGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
F L +AVL +GRV V CRR + A+ S G+ VA +QP W
Sbjct 130 FGVLAVADSPTQWIAVLVSVAAGRVAVVFACRRGILASGPSGFGALVADSQPLWAAIVWS 189
Query 182 AVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
L+A S A R W GP+ A+ HCV RFGG+ GDVLG A+EL+ T++AV
Sbjct 190 VPLIAASGFATDRWWLGPLVTASALVISVLCVRHCVRRFGGLNGDVLGFALELTVTLTAV 249
Query 242 TL 243
L
Sbjct 250 GL 251
>gi|296166081|ref|ZP_06848527.1| adenosylcobinamide-GDP ribazoletransferase [Mycobacterium parascrofulaceum
ATCC BAA-614]
gi|295898576|gb|EFG78136.1| adenosylcobinamide-GDP ribazoletransferase [Mycobacterium parascrofulaceum
ATCC BAA-614]
Length=141
Score = 160 bits (406), Expect = 1e-37, Method: Compositional matrix adjust.
Identities = 108/141 (77%), Positives = 115/141 (82%), Gaps = 4/141 (2%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGP--- 57
++RSLATAFAF TV+P PGS PMGRG MTALPVVGAALGALAAA+ W GA VFGP
Sbjct 1 MIRSLATAFAFGTVLPVPGSRNAPMGRGAMTALPVVGAALGALAAAVVWGGAHVFGPPGS 60
Query 58 -SSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVV 116
SS L G+L VA LL TRGLHIDGVADTADGLGCYGPP+RALAVMRDGSTGPFG AAVV
Sbjct 61 ISSALPGLLAVAALLAATRGLHIDGVADTADGLGCYGPPERALAVMRDGSTGPFGAAAVV 120
Query 117 LVIALQGLAFATLTTVGIAGI 137
LVIALQGLAFA L G G+
Sbjct 121 LVIALQGLAFAALGATGRPGL 141
>gi|325676918|ref|ZP_08156590.1| adenosylcobinamide-GDP ribazoletransferase [Rhodococcus equi
ATCC 33707]
gi|325552218|gb|EGD21908.1| adenosylcobinamide-GDP ribazoletransferase [Rhodococcus equi
ATCC 33707]
Length=253
Score = 157 bits (396), Expect = 2e-36, Method: Compositional matrix adjust.
Identities = 121/245 (50%), Positives = 155/245 (64%), Gaps = 13/245 (5%)
Query 5 LATAFAFATVIPT--PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP-L 61
L+TA ++ TV+P P GR + A PVVGA LGA AAA+ W V+ P L
Sbjct 8 LSTALSWLTVLPVRGPREIGRAEGRAAIGAAPVVGALLGAGAAAVLWV--LVWAGLDPAL 65
Query 62 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIAL 121
+G+LTV L V TRG+H+DG+ADTADGLGCYGPP+RA VMR G GPFGVAA+++ I +
Sbjct 66 AGLLTVGALAVSTRGMHVDGLADTADGLGCYGPPERAREVMRSGGAGPFGVAALIVTIGV 125
Query 122 QGLAFATLTT----VGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVV 177
Q LAF L + +AG AV +GRV+AV CRR +PA+ S G+ VA +QPA
Sbjct 126 QALAFGALGAGGAWIAVAG---AVATGRVSAVFACRRGIPASSPSGFGALVADSQPAWTA 182
Query 178 AAWLAVLLAVSVPAGP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELST 236
A W A ++ A P R WQGP+ ++VA+T L HCV RF GV GDVLG+AIE +
Sbjct 183 AVWGAAAAVAALWAVPDRWWQGPLVIVVALTGAILLVRHCVRRFAGVNGDVLGAAIEFTV 242
Query 237 TVSAV 241
+AV
Sbjct 243 AATAV 247
>gi|333918938|ref|YP_004492519.1| cobalamin synthase [Amycolicicoccus subflavus DQS3-9A1]
gi|333481159|gb|AEF39719.1| Cobalamin synthase [Amycolicicoccus subflavus DQS3-9A1]
Length=266
Score = 157 bits (396), Expect = 2e-36, Method: Compositional matrix adjust.
Identities = 104/238 (44%), Positives = 145/238 (61%), Gaps = 5/238 (2%)
Query 8 AFAFATVIPT--PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGML 65
AF++ TV+P P A G + A P +G LG L+A W + P+ PL+G+
Sbjct 24 AFSWLTVLPVRGPRIADRQAGSWAIAASPFIGLGLGVLSALALWGLVALEVPA-PLAGIA 82
Query 66 TVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLA 125
TVA+L ++TRG+H+DG+ADTADGLG YGPP++A AVM GS+GPFGVA +VL + Q A
Sbjct 83 TVALLALLTRGMHLDGLADTADGLGTYGPPEKAQAVMHSGSSGPFGVATLVLCLGAQAFA 142
Query 126 FATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVL 184
TL G + + +A+ + RV VL CR + +A G+ VAGTQ ++ WL
Sbjct 143 LGTLAEQGKLVAVVVAIATARVAVVLACRPGIRSARPEGFGALVAGTQSWAIIGTWLIAA 202
Query 185 LAVSVPAGP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAV 241
+ VS+ A P RP+QG I + VA+ HCV RFGG+ GDVLG+ +EL+ + AV
Sbjct 203 VFVSIVAVPDRPYQGTIVIAVALVLTFLFTNHCVRRFGGLNGDVLGAVLELTVVLIAV 260
>gi|111018159|ref|YP_701131.1| cobalamin synthase [Rhodococcus jostii RHA1]
gi|110817689|gb|ABG92973.1| cobalamin synthase [Rhodococcus jostii RHA1]
Length=246
Score = 155 bits (391), Expect = 7e-36, Method: Compositional matrix adjust.
Identities = 113/245 (47%), Positives = 148/245 (61%), Gaps = 4/245 (1%)
Query 2 MRSLATAFAFATVIPT--PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSS 59
M + AF++ TV+P P S GR + A PV G ALG LAA + WA G
Sbjct 1 MSGVLLAFSWLTVLPLRGPDSVDRVSGRRAIRAAPVTGIALGVLAAGLLWALVSA-GLDP 59
Query 60 PLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVI 119
L+G++TV + TRG+HIDG++DT DGLGCYGPP+RA AVM G GPFGV A+V+ +
Sbjct 60 ALAGLMTVGAHALATRGMHIDGLSDTVDGLGCYGPPERARAVMHSGGAGPFGVCALVICL 119
Query 120 ALQGLAFATL-TTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVA 178
QGLAF +L A +AV +GRV V C+R +PA+ G+ VA TQ
Sbjct 120 GAQGLAFGSLAAAGQFACAAVAVAAGRVAVVFACQRGIPASSTEGFGALVAETQSPWTGI 179
Query 179 AWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
AW LLA + WQGP+ V+VA+T A L AHCV RF G+ GDVLG+A+E++ TV
Sbjct 180 AWTVPLLAAAAWCTLPWWQGPVVVVVALTLTALLVAHCVRRFAGLNGDVLGAALEITVTV 239
Query 239 SAVTL 243
+A+ L
Sbjct 240 AAIGL 244
>gi|226360287|ref|YP_002778065.1| cobalamin synthase [Rhodococcus opacus B4]
gi|226238772|dbj|BAH49120.1| cobalamin (5'-phosphate) synthase [Rhodococcus opacus B4]
Length=246
Score = 154 bits (388), Expect = 2e-35, Method: Compositional matrix adjust.
Identities = 90/185 (49%), Positives = 119/185 (65%), Gaps = 1/185 (0%)
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
L+G++ V + TRG+H+DG++DT DGLGCYGPP+RA AVM G GPFGV A+V+ +
Sbjct 61 LAGLVAVGAHALATRGMHVDGLSDTVDGLGCYGPPERARAVMHSGGAGPFGVCALVICLG 120
Query 121 LQGLAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAA 179
QGLAF +L G A + +A+ +GRV V CRR +PA+ G+ VA TQ A
Sbjct 121 AQGLAFGSLAAAGQFACVAVAMAAGRVAVVFACRRGIPASSTEGFGALVAETQSPWSGLA 180
Query 180 WLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVS 239
W LLA + WQGP+ V A+T A L AHCV RF G+ GDVLG+A+E++ TVS
Sbjct 181 WTVPLLAAAAWCTSPWWQGPVVVTAALTLTALLVAHCVRRFAGMNGDVLGAALEITVTVS 240
Query 240 AVTLA 244
A+ LA
Sbjct 241 AIGLA 245
>gi|262202960|ref|YP_003274168.1| cobalamin-5-phosphate synthase CobS [Gordonia bronchialis DSM
43247]
gi|262086307|gb|ACY22275.1| cobalamin-5-phosphate synthase CobS [Gordonia bronchialis DSM
43247]
Length=261
Score = 150 bits (379), Expect = 2e-34, Method: Compositional matrix adjust.
Identities = 112/256 (44%), Positives = 144/256 (57%), Gaps = 16/256 (6%)
Query 2 MRSLATAFAFATVIPTPGSATTP---MGRGPMTALPVVGAALGALAAAIAWAGAQVFGPS 58
+R++ TAF + TV P TTP +G + A+P+VGA LGAL A + A A G
Sbjct 6 IRAVRTAFGWLTVFPVGAEDTTPDRTLGAAVIAAVPIVGAVLGALVALLGMALAHT-GIP 64
Query 59 SPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLV 118
+ L+GML VA+L + TRG+H+DG+ADTADGLGCYGPP R VMR G+ GPFGVA +VLV
Sbjct 65 ALLAGMLAVALLALTTRGMHLDGLADTADGLGCYGPPSRVTEVMRSGTVGPFGVATLVLV 124
Query 119 IALQGLAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVV 177
+ +QG+ F L AV GRV ++ RR + AH G+ VAGTQ +V
Sbjct 125 LGIQGVGFGALFDQSRWYDAAFAVALGRVGVLVAARRGLAPAHPDGFGALVAGTQRNALV 184
Query 178 AAWLAVLLAVSVPAGPRPWQGPIAVLVAVTA----------GAALAAHCVHRFGGVTGDV 227
A+ LA + G G + AVTA AHC R GG+TGDV
Sbjct 185 VW-AALALAAAAVCGFDVSTGVFDLPAAVTAMLVVLVVAVVVWLFTAHCARRMGGITGDV 243
Query 228 LGSAIELSTTVSAVTL 243
LG+ IEL T +S V L
Sbjct 244 LGATIELGTAISVVGL 259
>gi|296139245|ref|YP_003646488.1| cobalamin-5-phosphate synthase CobS [Tsukamurella paurometabola
DSM 20162]
gi|296027379|gb|ADG78149.1| cobalamin-5-phosphate synthase CobS [Tsukamurella paurometabola
DSM 20162]
Length=250
Score = 145 bits (366), Expect = 5e-33, Method: Compositional matrix adjust.
Identities = 111/248 (45%), Positives = 141/248 (57%), Gaps = 7/248 (2%)
Query 2 MRSLATAFAFATVIPTPGSATTPMGR----GPMTALPVVGAALGALAAAIAWAGAQVFGP 57
MR L TA A+ TV+P P + R + +PV GA +GA+ IAWA A G
Sbjct 1 MRFLPTALAWMTVLPVPRRLQPAVDRPGAGRVIFFVPVAGAVVGAIVTGIAWASAAA-GL 59
Query 58 SSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVL 117
L G L +A +VTRG+H+DG AD DGLG YGPP RA +MR GS GPFG AA+ L
Sbjct 60 PWVLIGALAIAGAALVTRGMHVDGFADCVDGLGSYGPPDRAREIMRQGSVGPFGAAALAL 119
Query 118 VIALQGLAFATL-TTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPV 176
V+ + A L I +A+ + RV AV+ CRR AA+ G+ AGTQ
Sbjct 120 VVLIDAAAIGDLADRAQWIAIGVAIGAARVAAVIGCRRGWCAANPDGFGALTAGTQGGAA 179
Query 177 VAAWLAVLLAVSVPAGPR-PWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELS 235
A W+ V ++ A P PWQGP+AV+ A+ A A HCV RFGGV+GDVLG IEL+
Sbjct 180 QAFWMFVAAIAAIWAVPDVPWQGPLAVVAAMLAAALAMRHCVRRFGGVSGDVLGFGIELA 239
Query 236 TTVSAVTL 243
T V+ V L
Sbjct 240 TAVALVGL 247
>gi|54023667|ref|YP_117909.1| cobalamin synthase [Nocardia farcinica IFM 10152]
gi|54015175|dbj|BAD56545.1| putative cobalamin 5'-phosphate synthase [Nocardia farcinica
IFM 10152]
Length=259
Score = 140 bits (354), Expect = 1e-31, Method: Compositional matrix adjust.
Identities = 112/244 (46%), Positives = 140/244 (58%), Gaps = 6/244 (2%)
Query 5 LATAFAFATVIPT--PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLS 62
L AF++ TV+P P + PVVG LGA AA + W+ G S+ L+
Sbjct 14 LRLAFSWLTVLPVRGPEEVDRAGAARAIALAPVVGVVLGAAAAGLTWSLVAA-GLSTGLA 72
Query 63 GMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQ 122
+L V L V RG+H+DG+ADTADGLG YGPP+RA +M+ G GPFGVAA+V + +
Sbjct 73 ALLAVGALAVAARGMHLDGLADTADGLGSYGPPERARQIMKGGDVGPFGVAAIVFAVGVP 132
Query 123 GLAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWL 181
LAF T G I LAV GRV VL CRR PAA G+ GS VA TQ W
Sbjct 133 ALAFGTAAAEGRWLAIGLAVALGRVVVVLACRR-APAAPGTGFGSLVAATQHPATGVVWT 191
Query 182 AVLLAVSVPAGP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSA 240
+ +V A P R W GP+ VLVAV A L HCV RF G++GDVLG+AIE + V+A
Sbjct 192 ILAAVCAVFAVPGRAWLGPLVVLVAVAAALLLVRHCVRRFEGLSGDVLGAAIETTVAVAA 251
Query 241 VTLA 244
V +
Sbjct 252 VGFS 255
>gi|256375495|ref|YP_003099155.1| cobalamin 5'-phosphate synthase [Actinosynnema mirum DSM 43827]
gi|255919798|gb|ACU35309.1| cobalamin 5'-phosphate synthase [Actinosynnema mirum DSM 43827]
Length=237
Score = 139 bits (349), Expect = 5e-31, Method: Compositional matrix adjust.
Identities = 84/163 (52%), Positives = 106/163 (66%), Gaps = 5/163 (3%)
Query 74 TRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG 133
TRG+H+DG+ADTADGLGCYGPP+RALAVM+DG GPFGV +++V+ + +A L V
Sbjct 70 TRGMHLDGLADTADGLGCYGPPERALAVMKDGGAGPFGVVTLIVVLGAEAVA---LGGVS 126
Query 134 IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGP 193
+ LA+ +GR VL C R VPAA LG+ VAG+Q A VV AW + L A
Sbjct 127 WGAVVLALTAGRAAFVLCCARGVPAARPEGLGALVAGSQSAGVVVAWWSALAVAG--ALV 184
Query 194 RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELST 236
PW+GP+ V +A AL H RFGGVTGDVLG+A E +T
Sbjct 185 DPWRGPLGVALAAAVVFALVGHTRRRFGGVTGDVLGAACEAAT 227
>gi|134098232|ref|YP_001103893.1| putative cobalamin 5'-phosphate synthase [Saccharopolyspora erythraea
NRRL 2338]
gi|291004347|ref|ZP_06562320.1| putative cobalamin 5'-phosphate synthase [Saccharopolyspora erythraea
NRRL 2338]
gi|133910855|emb|CAM00968.1| putative cobalamin 5'-phosphate synthase [Saccharopolyspora erythraea
NRRL 2338]
Length=244
Score = 135 bits (339), Expect = 7e-30, Method: Compositional matrix adjust.
Identities = 107/239 (45%), Positives = 140/239 (59%), Gaps = 7/239 (2%)
Query 2 MRSLATAFAFATVIPT-PGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
M L A ++ +V P G R + P+VGA +G +AAA+ W + P
Sbjct 1 MDGLRLAMSWLSVAPVRAGRVDARACRQAIALAPLVGALVGGVAAAVLWVLGALGAPPLL 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIA 120
+L VA L++VTRG+H+DG+ADT DGLGCYGPP+RALAVMRDG GPF V A+VLV+
Sbjct 61 AG-LLAVAALVLVTRGMHVDGLADTVDGLGCYGPPERALAVMRDGGAGPFAVVALVLVLG 119
Query 121 LQGLAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAA 179
+Q ++ L G A + +A +GR L CR VPAA +G+ VAG+QP VA
Sbjct 120 VQAVSLGELAAAGDWATVVVACAAGRAGFALCCRTGVPAARPEGMGALVAGSQPVWAVAV 179
Query 180 WLAVLLAVSVPAG-PRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTT 237
W +LL V AG W GP+AV A+ A H RFGG+TGDVLG+A E+ TT
Sbjct 180 WWLLLL---VAAGISHWWTGPVAVAAALAALLVFTHHVRRRFGGITGDVLGAASEIGTT 235
>gi|254774954|ref|ZP_05216470.1| cobalamin synthase [Mycobacterium avium subsp. avium ATCC 25291]
Length=122
Score = 123 bits (308), Expect = 3e-26, Method: Compositional matrix adjust.
Identities = 87/110 (80%), Positives = 92/110 (84%), Gaps = 0/110 (0%)
Query 2 MRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPL 61
MRSLATAFAF TV+P P PMGRG MTALPVVG ALGALAAA+AW G VFG SSPL
Sbjct 1 MRSLATAFAFGTVLPMPAGGRGPMGRGAMTALPVVGLALGALAAAVAWGGTVVFGRSSPL 60
Query 62 SGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFG 111
G+L VA LL++TRGLHIDGVADTADGLGCYGPP RA AVMRDGSTGPFG
Sbjct 61 GGLLAVAALLLITRGLHIDGVADTADGLGCYGPPDRARAVMRDGSTGPFG 110
>gi|326382504|ref|ZP_08204195.1| cobalamin synthase [Gordonia neofelifaecis NRRL B-59395]
gi|326198623|gb|EGD55806.1| cobalamin synthase [Gordonia neofelifaecis NRRL B-59395]
Length=262
Score = 120 bits (301), Expect = 2e-25, Method: Compositional matrix adjust.
Identities = 98/252 (39%), Positives = 134/252 (54%), Gaps = 17/252 (6%)
Query 7 TAFAFATVIPTP---GSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSPLSG 63
AF + TV+P P G + A+P+VGAALGA+ A IA+ + P++ L G
Sbjct 11 DAFTWLTVLPLPQPRGEFDRRRAATVIAAVPIVGAALGAVIAVIAFGLSYTALPTA-LIG 69
Query 64 MLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQG 123
+ VAVL + TRG+H+DG+ADT DGLG YG R A+MR G GPFG A++VLV+ +
Sbjct 70 VGMVAVLALATRGMHLDGLADTVDGLGSYGDADRVRAIMRSGDVGPFGAASLVLVLLGES 129
Query 124 LAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLA 182
+AF L I LA+ R T + CR + AA+ G+ VAGTQ A +V W A
Sbjct 130 VAFGALAADSRWYEIALAIFVSRATVPISCRSGLGAANADGFGALVAGTQRASIV-VWSA 188
Query 183 VLLAVSVPAGPRPWQGP-----------IAVLVAVTAGAALAAHCVHRFGGVTGDVLGSA 231
+ LA + G G V+V + HC R GG+TGDV+G+
Sbjct 189 LALAAAAATGLVGTDGQTLDVAAAVQATAVVVVVLFFAWFFTRHCARRSGGLTGDVIGAT 248
Query 232 IELSTTVSAVTL 243
IE S ++AV L
Sbjct 249 IEFSVVLTAVGL 260
>gi|331698326|ref|YP_004334565.1| Cobalamin synthase [Pseudonocardia dioxanivorans CB1190]
gi|326953015|gb|AEA26712.1| Cobalamin synthase [Pseudonocardia dioxanivorans CB1190]
Length=256
Score = 115 bits (288), Expect = 5e-24, Method: Compositional matrix adjust.
Identities = 107/251 (43%), Positives = 138/251 (55%), Gaps = 9/251 (3%)
Query 2 MRSLATAFAFATVIP----TPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGP 57
R LA A ++ TV+P T + + + PVVGA +GA++ A+AW G G
Sbjct 4 WRGLALALSWLTVLPVRAGTGSAPAAGVAAAAIRWAPVVGALVGAVSGALAW-GLVAAGV 62
Query 58 SSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGV----A 113
+ ++G+L VA ++ TRG+H+DG+ADTADGLGCYGPP+RALAVMRDG GPF V
Sbjct 63 PTLVAGLLGVAAGVLATRGMHVDGLADTADGLGCYGPPERALAVMRDGGAGPFAVVTLLV 122
Query 114 AVVLVIALQGLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQP 173
A+ A V A LA +GR RR VPAA LG+ VAG+QP
Sbjct 123 ALGAQAAALAAVAPLGPAVATAAGALAAATGRAGFAWCARRGVPAARPGGLGASVAGSQP 182
Query 174 APVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIE 233
V AAW +L A + P W G + V A L+AH RFGG+TGDVLG+A E
Sbjct 183 WWVAAAWWVLLAAAAALLVPARWPGVLGVAAAAVLVVGLSAHTRRRFGGMTGDVLGAASE 242
Query 234 LSTTVSAVTLA 244
L T V L+
Sbjct 243 LGVTAVLVVLS 253
>gi|213966508|ref|ZP_03394677.1| cobalamin-5-phosphate synthase [Corynebacterium amycolatum SK46]
gi|213950845|gb|EEB62258.1| cobalamin-5-phosphate synthase [Corynebacterium amycolatum SK46]
Length=290
Score = 114 bits (286), Expect = 1e-23, Method: Compositional matrix adjust.
Identities = 98/269 (37%), Positives = 127/269 (48%), Gaps = 30/269 (11%)
Query 1 VMRSLATAFAFATVIPTPGSATTP--MGRGPMTALPVVGAALGALAAAIAWAGAQVFGPS 58
V ++ TA ++ TV+P G++ GR + ALPV G A A I +F S
Sbjct 24 VAEAITTALSWLTVLPFKGASVFDRITGRRAIAALPVAGLVPAAGAVLIT---VGLFATS 80
Query 59 SP-----------LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGST 107
S L G L + +VTR +H+DG+AD AD LG Y PP+ A V+RD ST
Sbjct 81 SSRTPALYDVTPILGGALIMVAAQMVTRAMHLDGLADVADALGSYKPPEGAREVLRDPST 140
Query 108 GPFGVAAVVLVIALQGLAFATLTTV------------GIAGITLAVLSGRVTAVLVCRRL 155
GP GV ++VL + AFA + G+ + L ++ R A C R
Sbjct 141 GPMGVGSIVLTMLTTATAFAGIVASVLAQWSGDQVWPGVVALCLPFVASRAAATTACWRG 200
Query 156 VPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVTAGAALAAH 215
P S GS AGTQ V W +LLAVS A+ VT LA H
Sbjct 201 FPPFSSSGFGSLTAGTQSTVTVTCWWILLLAVSGWVVGLVGVVACALSFGVT--LLLARH 258
Query 216 CVHRFGGVTGDVLGSAIELSTTVSAVTLA 244
CV RFGGV GDVLG+ IE++ V A LA
Sbjct 259 CVKRFGGVNGDVLGAVIEIACAVCAGVLA 287
>gi|343924155|ref|ZP_08763718.1| cobalamin synthase [Gordonia alkanivorans NBRC 16433]
gi|343765960|dbj|GAA10644.1| cobalamin synthase [Gordonia alkanivorans NBRC 16433]
Length=266
Score = 112 bits (281), Expect = 4e-23, Method: Compositional matrix adjust.
Identities = 100/257 (39%), Positives = 142/257 (56%), Gaps = 17/257 (6%)
Query 2 MRSLATAFAFATVIPT---PGSATTP---MGRGPMTALPVVGAALGALAAAIAWAGAQVF 55
+R++ TA ++ TV+P + TP +G M+ALPVVG +GA AAA+A+ +
Sbjct 10 LRAVRTALSWMTVLPVGTGADAEETPDRAVGGAVMSALPVVGIVVGAAAAALAFGVSFTD 69
Query 56 GPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAV 115
P++ L G L V + +TRG+H+DG+ADTADGLGCYGPP+R VMR G+ GPFGVA +
Sbjct 70 LPTA-LIGALVVVLTAALTRGMHLDGLADTADGLGCYGPPERIAEVMRSGTVGPFGVATL 128
Query 116 VLVIALQGLAFATLTTVG-IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPA 174
VL + +Q L + + A+ GR+ AV+ RR + AH + G+ VAGTQ
Sbjct 129 VLTLGVQAAGSTGLVSESRWYELAFAIALGRLGAVVGTRRSISPAHPNGFGALVAGTQRL 188
Query 175 PVVAAWLAVLLAVSVPAGPRP--------WQGPIAVLVAVTAGAALAAHCVHRFGGVTGD 226
++ W + +VP G R Q + VL V HC R GG+ GD
Sbjct 189 S-ISVWGLLAAVATVPIGLRDNGFDAAAVVQALVVVLAVVVFAWVFTRHCARRMGGLNGD 247
Query 227 VLGSAIELSTTVSAVTL 243
VLG+ IEL ++ V L
Sbjct 248 VLGATIELGVALALVGL 264
>gi|330469403|ref|YP_004407146.1| cobalamin-5-phosphate synthase CobS [Verrucosispora maris AB-18-032]
gi|328812374|gb|AEB46546.1| cobalamin-5-phosphate synthase CobS [Verrucosispora maris AB-18-032]
Length=257
Score = 112 bits (280), Expect = 4e-23, Method: Compositional matrix adjust.
Identities = 83/171 (49%), Positives = 109/171 (64%), Gaps = 5/171 (2%)
Query 73 VTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLT-- 130
+TRGLH+DG+ADT D LG Y AL +M+ GPFGV A+VLV+ +Q A A L
Sbjct 78 LTRGLHLDGLADTVDALGSYRRGPAALEIMKKPDVGPFGVVALVLVLLMQVAALAELVDG 137
Query 131 --TVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVS 188
+ +A + A +GR+ L CRR VPAA LG+ VAGT +AA +A ++ ++
Sbjct 138 PGSAVLAAVVTASAAGRLGVTLACRRGVPAARPEGLGALVAGTVGPVALAAGIAAVMLLA 197
Query 189 VPAGP-RPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
VPA P RPWQGP+AVL A+ AAL H V R GG+TGDVLG+ +EL TT+
Sbjct 198 VPAVPDRPWQGPLAVLTALAVAAALLRHVVRRLGGITGDVLGAGVELVTTL 248
>gi|254822076|ref|ZP_05227077.1| cobalamin synthase [Mycobacterium intracellulare ATCC 13950]
Length=98
Score = 109 bits (272), Expect = 4e-22, Method: Compositional matrix adjust.
Identities = 70/98 (72%), Positives = 81/98 (83%), Gaps = 0/98 (0%)
Query 1 VMRSLATAFAFATVIPTPGSATTPMGRGPMTALPVVGAALGALAAAIAWAGAQVFGPSSP 60
++RSLATAFAF TV+P PG+ T PMGRG +TA PVVGA LGALAAAI W FG +P
Sbjct 1 MIRSLATAFAFGTVLPVPGARTAPMGRGALTAFPVVGAGLGALAAAITWGAELAFGRCTP 60
Query 61 LSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRA 98
L+G+L V VLL++TRGLH+DGVADTADGLGCYGPPQRA
Sbjct 61 LAGVLAVVVLLLITRGLHVDGVADTADGLGCYGPPQRA 98
>gi|158313619|ref|YP_001506127.1| cobalamin 5'-phosphate synthase [Frankia sp. EAN1pec]
gi|158109024|gb|ABW11221.1| cobalamin 5'-phosphate synthase [Frankia sp. EAN1pec]
Length=275
Score = 107 bits (267), Expect = 2e-21, Method: Compositional matrix adjust.
Identities = 93/257 (37%), Positives = 133/257 (52%), Gaps = 22/257 (8%)
Query 8 AFAFATVIPTPGSAT---TPMGRGPMTALPVVGAALGALAAAIAWAGAQVFG-----PSS 59
AF TV+P G T GR M P+VG LG ++A + V P +
Sbjct 7 AFTLLTVLPVRGPERLDRTVAGRA-MALAPLVGLVLGLVSALLVVTTRIVTKVPHERPQT 65
Query 60 PLSGMLTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVI 119
L +L V +L ++TRGLH+DG+AD D G G +RALAVMR+ + G FG V+ V+
Sbjct 66 MLPAVLGVTLLALLTRGLHLDGLADVGDAFGVRGGRERALAVMRESTIGAFGAITVLFVV 125
Query 120 ALQ--GLAFATLTTVGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGT-QPAPV 176
+Q L+ A G I +A ++GR+ A L C +P+A LG+ VAG+ +
Sbjct 126 LVQVSALSIAITAHRGTVSILVAAMAGRLAATLSCVEGIPSARPDGLGALVAGSVRRRDA 185
Query 177 VAAWLAVLLAVSVPAGPRPWQG---------PIAVLVAVTAGAALAAHCVHRFGGVTGDV 227
V A + VL+ + AG + G IAV V V AL V RFGG+TGD
Sbjct 186 VLATVGVLVVAGL-AGRLDYDGGDTGRAVRAIIAVAVGVAVSIALRRWLVRRFGGITGDT 244
Query 228 LGSAIELSTTVSAVTLA 244
LG+ IE+++ V+ +T+A
Sbjct 245 LGATIEITSMVTLLTMA 261
>gi|254774953|ref|ZP_05216469.1| cobalamin synthase [Mycobacterium avium subsp. avium ATCC 25291]
Length=103
Score = 105 bits (263), Expect = 4e-21, Method: Compositional matrix adjust.
Identities = 67/102 (66%), Positives = 81/102 (80%), Gaps = 0/102 (0%)
Query 148 AVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGPRPWQGPIAVLVAVT 207
AVL CRR VPAA GS+LG+ VAG+QPA V AAW+AVLL +S+ AGPRPW GP+AVL+ +
Sbjct 2 AVLACRRTVPAAAGSSLGATVAGSQPAAVAAAWVAVLLGMSLVAGPRPWHGPVAVLLGLG 61
Query 208 AGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVTLAGLARL 249
G L HCV RFGG++GDVLG+AIEL+ TVSAV LA L R+
Sbjct 62 CGGVLVRHCVRRFGGISGDVLGAAIELTATVSAVALAALVRV 103
>gi|257054907|ref|YP_003132739.1| cobalamin-5-phosphate synthase [Saccharomonospora viridis DSM
43017]
gi|256584779|gb|ACU95912.1| cobalamin-5-phosphate synthase [Saccharomonospora viridis DSM
43017]
Length=271
Score = 102 bits (253), Expect = 6e-20, Method: Compositional matrix adjust.
Identities = 77/182 (43%), Positives = 104/182 (58%), Gaps = 11/182 (6%)
Query 74 TRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG 133
+RGLH+DG+ADTADGL RAL VMR G GP GV +VL + Q A A + G
Sbjct 82 SRGLHLDGLADTADGLAASYDRDRALDVMRRGDVGPTGVVTLVLAVLTQVAALAGIVASG 141
Query 134 ------IAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAV 187
++ + +AV++GR L C R +P+A LG+ VAG+ P V A A+++A
Sbjct 142 PTPATAVSAMAIAVVAGRGMLPLCCVRGLPSARPEGLGAAVAGSVPPGVAAVVAALVIAA 201
Query 188 SVPA-----GPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTVSAVT 242
+ GP WQG +AVL+ A AL H V RFGGVTGDVLG+ +E +T V+ V
Sbjct 202 AAVVTAVVPGPPWWQGVLAVLLGWLAAGALLGHAVRRFGGVTGDVLGACVETATLVTLVV 261
Query 243 LA 244
+
Sbjct 262 FS 263
>gi|302529230|ref|ZP_07281572.1| cobalamin-5-phosphate synthase [Streptomyces sp. AA4]
gi|302438125|gb|EFL09941.1| cobalamin-5-phosphate synthase [Streptomyces sp. AA4]
Length=251
Score = 101 bits (251), Expect = 1e-19, Method: Compositional matrix adjust.
Identities = 76/164 (47%), Positives = 98/164 (60%), Gaps = 5/164 (3%)
Query 74 TRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQ--GLAFATLTT 131
+RGLH+DG+ADTADGLG +AL VMR G +GP GVA ++ V+ +Q L A
Sbjct 78 SRGLHLDGLADTADGLGASYDRAKALDVMRRGDSGPTGVATLLFVLLVQTGALTGAISHG 137
Query 132 VGIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLA--VSV 189
GIA L+VL GR L C R VP+A LG+ VAG+ P +V+A + VL A ++
Sbjct 138 HGIAAAVLSVLCGRCVLSLCCARGVPSARPEGLGATVAGSVPV-LVSATVFVLAAGCAAL 196
Query 190 PAGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIE 233
G W+G +AV + A A L A CV R GGVTGDVLG +E
Sbjct 197 APGLSWWRGVLAVALGYAAAAILLARCVQRIGGVTGDVLGGCVE 240
>gi|159039086|ref|YP_001538339.1| cobalamin-5-phosphate synthase CobS [Salinispora arenicola CNS-205]
gi|157917921|gb|ABV99348.1| cobalamin-5-phosphate synthase CobS [Salinispora arenicola CNS-205]
Length=257
Score = 98.6 bits (244), Expect = 7e-19, Method: Compositional matrix adjust.
Identities = 86/214 (41%), Positives = 118/214 (56%), Gaps = 7/214 (3%)
Query 30 MTALPVVGAALGALAAAIAWAGAQVFGPSSPLSGMLTVAVLLVVTRGLHIDGVADTADGL 89
M P VGA LGA+ A + F P +G+ TV ++TRGLH+DG+ADT D L
Sbjct 37 MALAPAVGALLGAVLAGVLLVTGG-FAPPLVAAGV-TVGTSALLTRGLHLDGLADTVDAL 94
Query 90 GCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGLAFATLTTVG----IAGITLAVLSGR 145
G Y AL +M+ GPFGV A+V+V+ +Q A L +A + A +GR
Sbjct 95 GSYRRGPAALEIMKKPDVGPFGVTALVVVLLVQAAVLAELAERSALATLAAVVTATATGR 154
Query 146 VTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLAVLLAVSVPAGP-RPWQGPIAVLV 204
+ + CRR +PAA LG+ VAGT P +AA + ++ A P RPWQGP+ V
Sbjct 155 LGVGVACRRGLPAARPDGLGALVAGTVGPPALAAGTVAVALLAFAAVPDRPWQGPLVVAA 214
Query 205 AVTAGAALAAHCVHRFGGVTGDVLGSAIELSTTV 238
A+ L H V R GG+TGDVLG+ +E+ TT+
Sbjct 215 ALATAVWLLRHVVRRLGGITGDVLGATVEVVTTL 248
>gi|258650432|ref|YP_003199588.1| cobalamin-5-phosphate synthase CobS [Nakamurella multipartita
DSM 44233]
gi|258553657|gb|ACV76599.1| cobalamin-5-phosphate synthase CobS [Nakamurella multipartita
DSM 44233]
Length=255
Score = 98.6 bits (244), Expect = 7e-19, Method: Compositional matrix adjust.
Identities = 78/176 (45%), Positives = 100/176 (57%), Gaps = 6/176 (3%)
Query 65 LTVAVLLVVTRGLHIDGVADTADGLGCYGPPQRALAVMRDGSTGPFGVAAVVLVIALQGL 124
LT+ + + +RGLH+DG+ADTADGLG RAL +MR G+ GP GV +V+V+ Q
Sbjct 69 LTIGAVALGSRGLHLDGLADTADGLGSGYDRTRALEIMRRGNVGPMGVTTLVVVLVAQIA 128
Query 125 AFATLTTV--GIAGITLAVLSGRVTAVLVCRRLVPAAHGSTLGSRVAGTQPAPVVAAWLA 182
A A + G + + V R +L C R VP A LG+ VAG P A L
Sbjct 129 ATAAMLARPGGFVLVGVLVCLSRSALLLACARGVPPARPDGLGAMVAGVVPRAGTVAGLL 188
Query 183 V---LLAVSVP-AGPRPWQGPIAVLVAVTAGAALAAHCVHRFGGVTGDVLGSAIEL 234
V + A VP AG W GP+AVLVA A A L CV RFGG+TGDV+G+ IE+
Sbjct 189 VTAGIAAAVVPIAGSAWWWGPLAVLVAGLAVAGLLTRCVRRFGGITGDVMGATIEI 244
Lambda K H
0.322 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 355796561820
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
Posted date: Sep 5, 2011 4:36 AM
Number of letters in database: 5,219,829,388
Number of sequences in database: 15,229,318
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40