BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2212 Length=378 Score E Sequences producing significant alignments: (Bits) Value gi|15609349|ref|NP_216728.1| hypothetical protein Rv2212 [Mycoba... 744 0.0 gi|15841703|ref|NP_336740.1| hypothetical protein MT2268 [Mycoba... 744 0.0 gi|289574898|ref|ZP_06455125.1| conserved hypothetical protein [... 743 0.0 gi|289750806|ref|ZP_06510184.1| conserved hypothetical protein [... 742 0.0 gi|323719112|gb|EGB28257.1| hypothetical protein TMMG_01492 [Myc... 735 0.0 gi|240168273|ref|ZP_04746932.1| hypothetical protein MkanA1_0311... 597 1e-168 gi|296166086|ref|ZP_06848531.1| adenylate cyclase [Mycobacterium... 560 1e-157 gi|183983248|ref|YP_001851539.1| adenylate cyclase [Mycobacteriu... 555 7e-156 gi|118467968|ref|YP_888556.1| adenylate and guanylate cyclase ca... 469 4e-130 gi|333990331|ref|YP_004522945.1| adenylate cyclase [Mycobacteriu... 455 7e-126 gi|226308544|ref|YP_002768504.1| adenylate cyclase [Rhodococcus ... 135 1e-29 gi|229488641|ref|ZP_04382507.1| adenylate cyclase [Rhodococcus e... 135 1e-29 gi|111022051|ref|YP_705023.1| adenylate cyclase [Rhodococcus jos... 129 1e-27 gi|257056835|ref|YP_003134667.1| family 3 adenylate cyclase [Sac... 128 2e-27 gi|226364555|ref|YP_002782337.1| adenylate cyclase [Rhodococcus ... 127 4e-27 gi|256390029|ref|YP_003111593.1| adenylate/guanylate cyclase [Ca... 125 2e-26 gi|296268690|ref|YP_003651322.1| adenylate/guanylate cyclase [Th... 124 3e-26 gi|297562866|ref|YP_003681840.1| adenylate/guanylate cyclase [No... 123 4e-26 gi|296137962|ref|YP_003645205.1| adenylate/guanylate cyclase [Ts... 122 1e-25 gi|119717714|ref|YP_924679.1| adenylate cyclase [Nocardioides sp... 122 1e-25 gi|312141612|ref|YP_004008948.1| adenylate/guanylate cyclase [Rh... 120 3e-25 gi|300783495|ref|YP_003763786.1| adenylate cyclase [Amycolatopsi... 120 6e-25 gi|325673132|ref|ZP_08152826.1| adenylate cyclase [Rhodococcus e... 119 8e-25 gi|333921659|ref|YP_004495240.1| adenylate/guanylate cyclase [Am... 119 9e-25 gi|284046120|ref|YP_003396460.1| adenylate/guanylate cyclase [Co... 118 2e-24 gi|271962871|ref|YP_003337067.1| adenylate cyclase [Streptospora... 118 2e-24 gi|326333791|ref|ZP_08200024.1| adenylate cyclase [Nocardioidace... 117 3e-24 gi|302524847|ref|ZP_07277189.1| adenylate cyclase [Streptomyces ... 116 8e-24 gi|284028309|ref|YP_003378240.1| adenylate/guanylate cyclase [Kr... 115 8e-24 gi|72162951|ref|YP_290608.1| adenylate cyclase [Thermobifida fus... 115 1e-23 gi|269128322|ref|YP_003301692.1| adenylate/guanylate cyclase [Th... 114 2e-23 gi|111018939|ref|YP_701911.1| adenylate cyclase [Rhodococcus jos... 114 4e-23 gi|296395295|ref|YP_003660179.1| adenylate/guanylate cyclase [Se... 113 6e-23 gi|134098563|ref|YP_001104224.1| adenylate cyclase [Saccharopoly... 112 1e-22 gi|317509276|ref|ZP_07966897.1| adenylate and Guanylate cyclase ... 112 1e-22 gi|291003220|ref|ZP_06561193.1| adenylate cyclase [Saccharopolys... 112 1e-22 gi|326329339|ref|ZP_08195664.1| adenylate cyclase [Nocardioidace... 111 2e-22 gi|226361039|ref|YP_002778817.1| adenylate cyclase [Rhodococcus ... 110 4e-22 gi|119714431|ref|YP_921396.1| adenylyl cyclase class-3/4/guanyly... 108 2e-21 gi|311743182|ref|ZP_07716990.1| adenylate cyclase [Aeromicrobium... 107 3e-21 gi|320532578|ref|ZP_08033383.1| adenylate and Guanylate cyclase ... 106 5e-21 gi|269795825|ref|YP_003315280.1| family 3 adenylate cyclase [San... 106 7e-21 gi|334336517|ref|YP_004541669.1| adenylate/guanylate cyclase [Is... 106 8e-21 gi|227497918|ref|ZP_03928098.1| adenylate cyclase [Actinomyces u... 104 2e-20 gi|340360749|ref|ZP_08683214.1| hypothetical protein HMPREF9062_... 103 4e-20 gi|269124425|ref|YP_003297795.1| adenylate/guanylate cyclase [Th... 103 4e-20 gi|343924407|ref|ZP_08763956.1| adenylate cyclase [Gordonia alka... 103 4e-20 gi|84498094|ref|ZP_00996891.1| adenylyl cyclase class-3/4/guanyl... 103 4e-20 gi|283458553|ref|YP_003363183.1| adenylate cyclase, family 3 [Ro... 102 7e-20 gi|326383576|ref|ZP_08205262.1| adenylyl cyclase class-3/4/guany... 102 8e-20 >gi|15609349|ref|NP_216728.1| hypothetical protein Rv2212 [Mycobacterium tuberculosis H37Rv] gi|31793391|ref|NP_855884.1| hypothetical protein Mb2235 [Mycobacterium bovis AF2122/97] gi|121638093|ref|YP_978317.1| hypothetical protein BCG_2228 [Mycobacterium bovis BCG str. Pasteur 1173P2] 49 more sequence titles Length=378 Score = 744 bits (1921), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/378 (99%), Positives = 378/378 (100%), Gaps = 0/378 (0%) Query 1 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 +YDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP Sbjct 1 MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG Sbjct 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 Query 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID Sbjct 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 Query 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV Sbjct 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 Query 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA Sbjct 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 Query 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL Sbjct 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 Query 361 HDNPRARDADTPSPAASD 378 HDNPRARDADTPSPAASD Sbjct 361 HDNPRARDADTPSPAASD 378 >gi|15841703|ref|NP_336740.1| hypothetical protein MT2268 [Mycobacterium tuberculosis CDC1551] gi|308232068|ref|ZP_07414801.2| hypothetical protein TMAG_00401 [Mycobacterium tuberculosis SUMu001] gi|308369657|ref|ZP_07418578.2| hypothetical protein TMBG_00759 [Mycobacterium tuberculosis SUMu002] 21 more sequence titles Length=388 Score = 744 bits (1920), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/378 (100%), Positives = 378/378 (100%), Gaps = 0/378 (0%) Query 1 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP Sbjct 11 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 70 Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG Sbjct 71 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 130 Query 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID Sbjct 131 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 190 Query 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV Sbjct 191 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 250 Query 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA Sbjct 251 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 310 Query 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL Sbjct 311 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 370 Query 361 HDNPRARDADTPSPAASD 378 HDNPRARDADTPSPAASD Sbjct 371 HDNPRARDADTPSPAASD 388 >gi|289574898|ref|ZP_06455125.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] gi|339632239|ref|YP_004723881.1| hypothetical protein MAF_22230 [Mycobacterium africanum GM041182] gi|289539329|gb|EFD43907.1| conserved hypothetical protein [Mycobacterium tuberculosis K85] gi|339331595|emb|CCC27293.1| conserved hypothetical protein [Mycobacterium africanum GM041182] Length=378 Score = 743 bits (1918), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/378 (99%), Positives = 378/378 (100%), Gaps = 0/378 (0%) Query 1 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 +YDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP Sbjct 1 MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG Sbjct 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 Query 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID Sbjct 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 Query 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV Sbjct 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 Query 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA Sbjct 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 Query 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 LNGDYFGNPVNLAARLVAAAAPGQILAAAQ+RDMLPDWPALAHGPLTLKGFDAPVMAFEL Sbjct 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQIRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 Query 361 HDNPRARDADTPSPAASD 378 HDNPRARDADTPSPAASD Sbjct 361 HDNPRARDADTPSPAASD 378 >gi|289750806|ref|ZP_06510184.1| conserved hypothetical protein [Mycobacterium tuberculosis T92] gi|289691393|gb|EFD58822.1| conserved hypothetical protein [Mycobacterium tuberculosis T92] Length=378 Score = 742 bits (1915), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/378 (99%), Positives = 378/378 (100%), Gaps = 0/378 (0%) Query 1 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 +YDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP Sbjct 1 MYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG Sbjct 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 Query 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID Sbjct 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 Query 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV Sbjct 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 Query 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA Sbjct 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 Query 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRD+LPDWPALAHGPLTLKGFDAPVMAFEL Sbjct 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDILPDWPALAHGPLTLKGFDAPVMAFEL 360 Query 361 HDNPRARDADTPSPAASD 378 HDNPRARDADTPSPAASD Sbjct 361 HDNPRARDADTPSPAASD 378 >gi|323719112|gb|EGB28257.1| hypothetical protein TMMG_01492 [Mycobacterium tuberculosis CDC1551A] gi|339295126|gb|AEJ47237.1| hypothetical protein CCDC5079_2047 [Mycobacterium tuberculosis CCDC5079] gi|339298747|gb|AEJ50857.1| hypothetical protein CCDC5180_2020 [Mycobacterium tuberculosis CCDC5180] Length=374 Score = 735 bits (1898), Expect = 0.0, Method: Compositional matrix adjust. Identities = 373/374 (99%), Positives = 374/374 (100%), Gaps = 0/374 (0%) Query 5 LDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYT 64 +DFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYT Sbjct 1 MDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYT 60 Query 65 LATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGL 124 LATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGL Sbjct 61 LATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGL 120 Query 125 LRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHR 184 LRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHR Sbjct 121 LRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHR 180 Query 185 HHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVV 244 HHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVV Sbjct 181 HHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVV 240 Query 245 HADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGD 304 HADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGD Sbjct 241 HADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGD 300 Query 305 YFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNP 364 YFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNP Sbjct 301 YFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNP 360 Query 365 RARDADTPSPAASD 378 RARDADTPSPAASD Sbjct 361 RARDADTPSPAASD 374 >gi|240168273|ref|ZP_04746932.1| hypothetical protein MkanA1_03112 [Mycobacterium kansasii ATCC 12478] Length=378 Score = 597 bits (1539), Expect = 1e-168, Method: Compositional matrix adjust. Identities = 311/372 (84%), Positives = 337/372 (91%), Gaps = 4/372 (1%) Query 3 DSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPI 62 DSLDF+ALEAAGIA+PR RA L+ YLD LGFTV++M +AERRGRLFGLAGDVL WSGPPI Sbjct 9 DSLDFEALEAAGIADPRGRADLIKYLDGLGFTVDQMAEAERRGRLFGLAGDVLQWSGPPI 68 Query 63 YTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAF 122 +T+ +AADELGLSA++VAR W+LLGLTV GPDV LSQADVDALATWVALKA+VG+DGA+ Sbjct 69 HTVQSAADELGLSAEEVARVWALLGLTVTGPDVAALSQADVDALATWVALKAVVGQDGAY 128 Query 123 GLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTV 182 GLLRV+GTAMARLAEAESTMIRAG P+IQMTHTHDELATA+AYRA AEFVPRIG LID V Sbjct 129 GLLRVVGTAMARLAEAESTMIRAGMPDIQMTHTHDELATAQAYRAIAEFVPRIGNLIDVV 188 Query 183 HRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTD 242 HRHHL SARTYFEGV+ DTSASVTCGIGFADLSSFTALTQ LTPAQLQDLLTEF A V D Sbjct 189 HRHHLTSARTYFEGVVQDTSASVTCGIGFADLSSFTALTQMLTPAQLQDLLTEFGATVAD 248 Query 243 VVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALN 302 VVHADGGRLVKFIGDAVMWVS +P RLV+AAVDLVDHP AR A+LQVRAGLAYGTVLA+N Sbjct 249 VVHADGGRLVKFIGDAVMWVSPTPVRLVQAAVDLVDHPRAREADLQVRAGLAYGTVLAIN 308 Query 303 GDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHD 362 GDYFG+PVNLAARLVA AAPGQILAA++L D LPDWPA AHGPLTLKGFDAPV AFEL Sbjct 309 GDYFGSPVNLAARLVAVAAPGQILAASELHDKLPDWPATAHGPLTLKGFDAPVTAFEL-- 366 Query 363 NPRARDADTPSP 374 RARDAD PSP Sbjct 367 --RARDADGPSP 376 >gi|296166086|ref|ZP_06848531.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295898495|gb|EFG78056.1| adenylate cyclase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=374 Score = 560 bits (1444), Expect = 1e-157, Method: Compositional matrix adjust. Identities = 289/378 (77%), Positives = 317/378 (84%), Gaps = 4/378 (1%) Query 1 VYDSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP 60 + DS DF+ALEAAGI RERA L+ YLDELGFTV+EMV+AERRGRLFGLAGDVL WSG Sbjct 1 MVDSPDFEALEAAGIVRARERADLIKYLDELGFTVDEMVEAERRGRLFGLAGDVLQWSGR 60 Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDG 120 P++T+A+AA++LGLS D+VA+AW LLGLTVAGPDVPTLSQADVDALATWVALK +VGEDG Sbjct 61 PVHTMASAAEQLGLSPDEVAQAWGLLGLTVAGPDVPTLSQADVDALATWVALKTVVGEDG 120 Query 121 AFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALID 180 AFGLLRVLG AMARLAEAEST IRAG+P+IQMT+T+DELATA+AYRA AEFVPRI ALID Sbjct 121 AFGLLRVLGAAMARLAEAESTAIRAGTPDIQMTYTNDELATAQAYRAVAEFVPRISALID 180 Query 181 TVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAV 240 VHRHHL ART+FEGV+ DTSASV CGIGFADLS FT LT+ALTPAQL LL EF V Sbjct 181 VVHRHHLTGARTHFEGVLRDTSASVVCGIGFADLSGFTVLTRALTPAQLSALLNEFAGTV 240 Query 241 TDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLA 300 DVVH DGGR+VKFIGD VMWVS+SPE L AA DLVDHP AR LQVRAGLA+GTVLA Sbjct 241 ADVVHRDGGRVVKFIGDEVMWVSASPEHLATAAADLVDHPRAREEGLQVRAGLAFGTVLA 300 Query 301 LNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFEL 360 +NGDYFG+PVNLAARLV AAAPGQILA A L + LPDWPA A GP LKGFDAPV AFEL Sbjct 301 INGDYFGSPVNLAARLVGAAAPGQILADAALHEQLPDWPAAARGPFDLKGFDAPVDAFEL 360 Query 361 HDNPRARDADTPSPAASD 378 H RDA P P D Sbjct 361 H----GRDAADPGPGPGD 374 >gi|183983248|ref|YP_001851539.1| adenylate cyclase [Mycobacterium marinum M] gi|183176574|gb|ACC41684.1| adenylate cyclase [Mycobacterium marinum M] Length=381 Score = 555 bits (1429), Expect = 7e-156, Method: Compositional matrix adjust. Identities = 289/376 (77%), Positives = 317/376 (85%), Gaps = 0/376 (0%) Query 3 DSLDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPI 62 D LDF+ALEAAGIANPRERA L+ YLD+LGFT+EEM +AERRGRLFGLAGDVL W GPPI Sbjct 6 DPLDFEALEAAGIANPRERADLIKYLDDLGFTLEEMAEAERRGRLFGLAGDVLQWPGPPI 65 Query 63 YTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAF 122 YTL A ++LGLSADD+A W+LLGLTVAGPDVPTLSQADVDALATW+A+K++VGEDGAF Sbjct 66 YTLTAAGEQLGLSADDIAHIWALLGLTVAGPDVPTLSQADVDALATWLAVKSVVGEDGAF 125 Query 123 GLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTV 182 GLLRVLG AMARLAEAESTMIRAG+P+IQMT+T+DELATA+AYRA AEFVPRIG LID V Sbjct 126 GLLRVLGAAMARLAEAESTMIRAGTPDIQMTYTNDELATAQAYRAVAEFVPRIGTLIDIV 185 Query 183 HRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTD 242 HRHHL SART+FEGV D SASV CGIGFADLSSFT LTQ LTP +LQ LL EF AAV D Sbjct 186 HRHHLTSARTHFEGVTRDASASVVCGIGFADLSSFTVLTQTLTPTELQGLLNEFGAAVAD 245 Query 243 VVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALN 302 VVHADGGR+VKFIGDAVMWVSS+P+RL +AAVDLV HP AR LQVRAGLAYGT LA+N Sbjct 246 VVHADGGRVVKFIGDAVMWVSSTPQRLAQAAVDLVHHPRAREEGLQVRAGLAYGTALAIN 305 Query 303 GDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHD 362 GDYFG PVNLAARLVAAAAPGQ+LA A L D LPDWP + G LTLKGFD PV AFEL Sbjct 306 GDYFGTPVNLAARLVAAAAPGQVLADAALHDQLPDWPTIPRGKLTLKGFDDPVNAFELQG 365 Query 363 NPRARDADTPSPAASD 378 + D P D Sbjct 366 SADRPDGGQAGPRCGD 381 >gi|118467968|ref|YP_888556.1| adenylate and guanylate cyclase catalytic domain-containing protein [Mycobacterium smegmatis str. MC2 155] gi|118169255|gb|ABK70151.1| adenylate and Guanylate cyclase catalytic domain protein [Mycobacterium smegmatis str. MC2 155] Length=363 Score = 469 bits (1206), Expect = 4e-130, Method: Compositional matrix adjust. Identities = 239/361 (67%), Positives = 284/361 (79%), Gaps = 2/361 (0%) Query 5 LDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYT 64 +DFDALEAAGIA+ R RAGL++YLD LGFT EEMV AERRGRLFGLAGD L SGP I++ Sbjct 2 VDFDALEAAGIADARRRAGLISYLDRLGFTAEEMVDAERRGRLFGLAGDRLQASGPAIHS 61 Query 65 LATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGL 124 LA+AADELGL +V RAW+ LGLTVAG DVP LS ADV+ L TW ++A +G+ A GL Sbjct 62 LASAADELGLPVAEVERAWAALGLTVAGVDVPALSAADVEGLRTWSEMRAFLGDQAATGL 121 Query 125 LRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHR 184 LRV+G+A+AR++EAES+M+RA SP+I + THDELATA+AYR AA ++PRIGAL+D HR Sbjct 122 LRVIGSALARISEAESSMVRATSPDIMIDVTHDELATAQAYRTAAAYIPRIGALMDAAHR 181 Query 185 HHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVV 244 HHL S RTYFE VI D S + CG+GFADLS FTALTQ LT +L DLL EF +A +DVV Sbjct 182 HHLMSTRTYFEHVIRDGSTTGECGVGFADLSDFTALTQMLTTVELTDLLNEFSSAASDVV 241 Query 245 HADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGD 304 HA GGR+VKFIGDAVMWV+++P L RAAVDLV+HP AR A ++VRAGL +G VLA+NGD Sbjct 242 HAAGGRVVKFIGDAVMWVATTPHLLARAAVDLVEHPKARQAHVRVRAGLDFGAVLAINGD 301 Query 305 YFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELHDNP 364 YFGN VNLAARLV AA PGQ+L +A LR+ L DWPA L LKGFD P+ AF L P Sbjct 302 YFGNSVNLAARLVQAAEPGQVLVSAALREALGDWPATGPRELKLKGFDHPIPAFAL--TP 359 Query 365 R 365 R Sbjct 360 R 360 >gi|333990331|ref|YP_004522945.1| adenylate cyclase [Mycobacterium sp. JDM601] gi|333486299|gb|AEF35691.1| adenylate cyclase [Mycobacterium sp. JDM601] Length=362 Score = 455 bits (1170), Expect = 7e-126, Method: Compositional matrix adjust. Identities = 229/357 (65%), Positives = 274/357 (77%), Gaps = 1/357 (0%) Query 5 LDFDALEAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYT 64 +D+DAL AAGI++ R+RA LL YLD LGF+ E+M +AER+GRLFGLAGDV+ SGPP YT Sbjct 2 VDWDALTAAGISDARQRADLLEYLDGLGFSTEQMAEAERQGRLFGLAGDVVGRSGPPDYT 61 Query 65 LATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAFGL 124 L TAA+ L + DV RAW++LGL+V PD P LSQADVD LATWV +++ +GE G Sbjct 62 LRTAAEALRIPVGDVERAWTMLGLSVDSPDTPALSQADVDGLATWVQMRSYLGEP-VDGF 120 Query 125 LRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHR 184 LRVLG MARLAEAES+MIR P++ + HTH EL TARA+R AE++PRIGA+ID VHR Sbjct 121 LRVLGATMARLAEAESSMIRISEPDMWLGHTHSELRTARAWRTVAEYIPRIGAMIDAVHR 180 Query 185 HHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVV 244 H SART+ EG+ G ++S+ CG+GFADL+ FTALTQ LT +L LLT+F +V DVV Sbjct 181 QHQVSARTFLEGLAGGPTSSMVCGVGFADLTGFTALTQVLTSEELATLLTDFGGSVADVV 240 Query 245 HADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGD 304 HADGGR+VKFIGDAVMWVS+S E L +AA DLVDHP AR LQVRAGL YG VLA+NGD Sbjct 241 HADGGRVVKFIGDAVMWVSASGELLAKAATDLVDHPKARKVGLQVRAGLGYGEVLAINGD 300 Query 305 YFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPLTLKGFDAPVMAFELH 361 YFG PVNLAARLV AA PGQ+LA A + LPDWP + GPL LKGFD PV A+EL Sbjct 301 YFGTPVNLAARLVDAAEPGQVLACAGVVKELPDWPVVERGPLKLKGFDEPVPAYELE 357 >gi|226308544|ref|YP_002768504.1| adenylate cyclase [Rhodococcus erythropolis PR4] gi|226187661|dbj|BAH35765.1| putative adenylate cyclase [Rhodococcus erythropolis PR4] Length=381 Score = 135 bits (340), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 93/289 (33%), Positives = 148/289 (52%), Gaps = 21/289 (7%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTV-AGPDVPTLSQADVDALATWVAL-- 112 L GP +T + AD G++ + R W +G V PD +Q D DAL T + Sbjct 64 LLGGPRCFTQSQIADFAGVTRERADRLWVAMGFAVDEDPDAVMFTQQDADALKTITDMVN 123 Query 113 KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRA----- 167 + ++ ++ R LG +M+RLAE + ++I TH D+LA + + Sbjct 124 RGVISQNSEVAAARSLGQSMSRLAEWQVSLIS--------THIIDQLADSVDHEPDAIRN 175 Query 168 -----AAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQ 222 AE +P + +L V + H+AS+ G G+ AS +GFAD+ +T+LT+ Sbjct 176 VVLSLGAEIIPAVESLQTYVWKRHVASSTGRNVGNPGEEVASRVLVVGFADIVGYTSLTR 235 Query 223 ALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGA 282 L A+L DLL F++A T+++ + G +VK +GD VM+ + SP A+ + A Sbjct 236 GLDSAELNDLLERFESASTEIIGRNYGWVVKTVGDEVMFAAESPHHAAEIALQIQQAVLA 295 Query 283 RAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQL 331 + Q+R GLA G L GD +G+ VN AARL ++A PG +L ++L Sbjct 296 DHDDPQLRVGLAMGPTLVRFGDLYGSVVNKAARLTSSARPGTVLIDSEL 344 >gi|229488641|ref|ZP_04382507.1| adenylate cyclase [Rhodococcus erythropolis SK121] gi|229324145|gb|EEN89900.1| adenylate cyclase [Rhodococcus erythropolis SK121] Length=381 Score = 135 bits (339), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 93/293 (32%), Positives = 150/293 (52%), Gaps = 21/293 (7%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTV-AGPDVPTLSQADVDALATWVAL-- 112 L GP +T + A+ G++ + R W +G V PD +Q D +AL T + + Sbjct 64 LLGGPRCFTQSQIAEFAGVTRERADRLWVAMGFAVDEDPDAVMFTQQDANALKTIIDMVN 123 Query 113 KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAY------- 165 + ++ + R LG +M+RLAE + ++I TH D+LA + + Sbjct 124 RGVISQSSEVAAARSLGQSMSRLAEWQVSLIS--------THIIDQLADSADHEPEAIRK 175 Query 166 ---RAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQ 222 R AE +P + +L V + H+AS+ G G+ AS +GFAD+ +T+LT+ Sbjct 176 IVLRLGAEIIPAVESLQTYVWKRHVASSTGRNVGNPGEEVASRVLVVGFADIVGYTSLTR 235 Query 223 ALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGA 282 L A+L DLL F++A T+++ + G +VK +GD VM+ + SP A+ + A Sbjct 236 GLDSAELNDLLERFESASTEIIGRNYGWVVKTVGDEVMFAAESPHHAAEIALQIQQAVLA 295 Query 283 RAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDML 335 + Q+R GLA G L GD +G+ VN AARL ++A PG +L ++L L Sbjct 296 DHDDPQLRVGLAMGPTLVRFGDLYGSVVNKAARLTSSARPGTVLIDSELATQL 348 >gi|111022051|ref|YP_705023.1| adenylate cyclase [Rhodococcus jostii RHA1] gi|110821581|gb|ABG96865.1| probable adenylate cyclase [Rhodococcus jostii RHA1] Length=351 Score = 129 bits (323), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 102/297 (35%), Positives = 145/297 (49%), Gaps = 21/297 (7%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTV-AGPDVPTLSQADVDALATWVAL-- 112 L GP YT A AD G+S + R W +G V PD ++ D AL T +L Sbjct 34 LLGGPRRYTRAEIADFAGVSLERADRLWVSMGFAVDTDPDGVMFTEGDAAALRTIASLVD 93 Query 113 KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATA-----RAYRA 167 + ++ + R LG AM+RLAE + ++I TH D+LA + +A R Sbjct 94 QGIISPEREVAAARALGQAMSRLAEWQVSLIS--------THIVDQLAGSAGSDEQAIRE 145 Query 168 -----AAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQ 222 AE +P + +L V R H+AS G G+ AS +GFAD+ +T+LT+ Sbjct 146 QVRELTAEILPAVESLQAYVWRRHIASTTGRNVGNPGEEVASRKLVVGFADIVGYTSLTR 205 Query 223 ALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGA 282 L +L DLL F++A T V+ G +VK +GD VM+ SP A+ L + Sbjct 206 QLGARELSDLLERFESASTSVIGRHQGWVVKTVGDEVMFAVESPADAAEIALQLREQVLP 265 Query 283 RAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWP 339 + ++R GLA G VL GD +G+ VN AARL +A PG +L L L D P Sbjct 266 DETDPELRVGLAMGPVLVRFGDLYGSVVNTAARLTGSARPGTVLIDEALAHELADAP 322 >gi|257056835|ref|YP_003134667.1| family 3 adenylate cyclase [Saccharomonospora viridis DSM 43017] gi|256586707|gb|ACU97840.1| family 3 adenylate cyclase [Saccharomonospora viridis DSM 43017] Length=346 Score = 128 bits (321), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 93/287 (33%), Positives = 141/287 (50%), Gaps = 8/287 (2%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDA--LATWVALK 113 L GP YT A + G+S + + W LG G D + ADV+A +A + + Sbjct 15 LLGGPRRYTRLEVAAKSGVSPERARQLWRALGFASVGDDEVVFTDADVEAVRIADRLVGE 74 Query 114 ALVGEDGAFGLLRVLGTAMARLAEAESTMIRA-GSPNIQMTHTHDELATARAYRAAAEFV 172 L+ D + R +G M+RLAE +S ++R+ + N + ++LA + Sbjct 75 GLLDRDLETSVARAVGLHMSRLAEWQSQLLRSLIADNPHLAERPEQLAEL-----VERLL 129 Query 173 PRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDL 232 P++G L D R HL + + S +GF D+ +T + + A+L + Sbjct 130 PQLGRLHDFAWRRHLVAYSGRALAASHEQLESRHQVVGFVDMVGYTRMVRRFDEAELSAV 189 Query 233 LTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAG 292 L F++ T+VV GR+VK IGD V++V S P A+ L + GA +VRAG Sbjct 190 LERFESLATEVVVEHHGRVVKLIGDEVLFVCSQPVEAAEIALTLTEQAGADERLPEVRAG 249 Query 293 LAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWP 339 LA G VL+ GD +G+ VNLA+RL A PG +L A L D L + P Sbjct 250 LASGRVLSRFGDVYGSVVNLASRLTELARPGTVLVNATLADALAEEP 296 >gi|226364555|ref|YP_002782337.1| adenylate cyclase [Rhodococcus opacus B4] gi|226243044|dbj|BAH53392.1| adenylate cyclase [Rhodococcus opacus B4] Length=385 Score = 127 bits (318), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 98/297 (33%), Positives = 144/297 (49%), Gaps = 21/297 (7%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTV-AGPDVPTLSQADVDALATWVAL-- 112 L GP YT A AD G+S + R W +G V PD ++ D AL T +L Sbjct 68 LLGGPRRYTRAEIADVAGVSLERADRLWVSMGFAVDIDPDSVMFTEGDAAALRTMASLVD 127 Query 113 KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATA---------- 162 + ++ + R LG +++RLAE + ++I TH D+LA + Sbjct 128 RGIISPEREVAAARALGQSLSRLAEWQVSLI--------STHIVDQLAGSADSDEQEIRE 179 Query 163 RAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQ 222 + AE +P + +L V R H+AS G G+ AS +GFAD+ +T+LT+ Sbjct 180 QVRGLTAEILPAVESLQAYVWRRHVASTTGRNVGNPGEEVASRNLVVGFADIVGYTSLTR 239 Query 223 ALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGA 282 L L DLL F++A T V+ G +VK +GD VM+ SP A+ L + Sbjct 240 QLGARDLADLLERFESASTTVIGGHQGWVVKTVGDEVMFAVESPADAAEIALQLQERVLP 299 Query 283 RAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWP 339 + ++R GLA G VL GD +G+ VN AARL +A PG +L +L D L + P Sbjct 300 DETDPELRVGLAMGPVLVRFGDLYGSVVNTAARLTGSARPGTVLIDEELADELAEAP 356 >gi|256390029|ref|YP_003111593.1| adenylate/guanylate cyclase [Catenulispora acidiphila DSM 44928] gi|256356255|gb|ACU69752.1| adenylate/guanylate cyclase [Catenulispora acidiphila DSM 44928] Length=435 Score = 125 bits (313), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 99/309 (33%), Positives = 147/309 (48%), Gaps = 20/309 (6%) Query 53 DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL 112 + LL G P +T G+ D+ R W +G G + ADVDAL + Sbjct 125 EALLLGGVPRHTAYEVCKAAGIPYDEARRYWRAMGFADVG-QARAFTDADVDALLRLGGM 183 Query 113 --KALVGEDGAFGLLRVLGTAMARLAEAESTMI-----RAGSPNIQMTHTHDELATARAY 165 L ED A + R +G ARLAE + ++ AG + +M Y Sbjct 184 PRSGLFTEDFAVQVARSMGQTTARLAEWQVDVLFDAFDTAGVGSEEMAEF--------GY 235 Query 166 RAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALT 225 R +P + L+ V R LA+A + + + + +GFADL SFT L++ L+ Sbjct 236 RIGRRVLPELEELLVYVWRRQLAAAAGRVRQQLQEHAEGLQA-VGFADLVSFTRLSRQLS 294 Query 226 PAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAA 285 +L L++ F+A D V GGRL+K +GD +M+ + SP R R A+DL+ A Sbjct 295 EEELARLVSVFEANAADTVAYGGGRLIKTLGDEIMFAADSPARAARIALDLLASMRRTEA 354 Query 286 ELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDML---PDWPALA 342 ++R G+AYG V+ NGD +G VNLAARL + A P QI+ +L L D+ A Sbjct 355 VPELRIGVAYGHVVQRNGDIYGTTVNLAARLTSLAEPDQIVVDPELAKALASDSDFALEA 414 Query 343 HGPLTLKGF 351 G ++G Sbjct 415 IGTRMVRGL 423 >gi|296268690|ref|YP_003651322.1| adenylate/guanylate cyclase [Thermobispora bispora DSM 43833] gi|296091477|gb|ADG87429.1| adenylate/guanylate cyclase [Thermobispora bispora DSM 43833] Length=337 Score = 124 bits (310), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 93/276 (34%), Positives = 135/276 (49%), Gaps = 7/276 (2%) Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVA-LKA-LVGE 118 P+YT + G+ D +R W LG D S+ADV AL A L+A L+ E Sbjct 21 PVYTRRQVIEAAGVRPDFASRIWRALGFPAPADDAVAFSEADVAALRRVRAHLEAGLLDE 80 Query 119 DGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGAL 178 + R LG ARLA+ ++ ++ S ++ E R +P + Sbjct 81 QTTIRMARALGRTTARLAQWQAEIM--TSSLLEQPGRPGEADLERVMETTRRLLPDFEQM 138 Query 179 IDTVHRHHLASARTYFEGVIGDTSASV---TCGIGFADLSSFTALTQALTPAQLQDLLTE 235 + V R L+ A + + A +GFADL +FT +++ L L +L+ Sbjct 139 LVHVWRSQLSVATSRLLSLAEGEEAQPGRPCLAVGFADLVAFTKVSRELDEPALAELVER 198 Query 236 FDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAY 295 F++ +DV+ A GGRLVK +GD V++ S P + A+DLV + VR GLAY Sbjct 199 FESRASDVIAAHGGRLVKTLGDEVLFTSDEPSGVASIALDLVSELKRDKSGPDVRIGLAY 258 Query 296 GTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQL 331 G V+ L GD FG VNLAARL + A PG I+A A+L Sbjct 259 GPVVPLMGDVFGATVNLAARLTSIARPGTIIADAEL 294 >gi|297562866|ref|YP_003681840.1| adenylate/guanylate cyclase [Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] gi|296847314|gb|ADH69334.1| adenylate/guanylate cyclase [Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111] Length=334 Score = 123 bits (309), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 87/291 (30%), Positives = 141/291 (49%), Gaps = 11/291 (3%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDAL--ATWVALK 113 L G +YT A + G + R W LG G D T +++DV++L A + + Sbjct 21 LLGGEAVYTREQAIELAGADNELAGRIWRALGFPNQGDDTVTFAESDVESLRIANSLVQE 80 Query 114 ALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVP 173 ++ E+G R +G MARLA+ +++++ + + E + + E +P Sbjct 81 GVLDEEGVVRFARAMGQTMARLADWQTSILST------LIYQEGEDSVSPLMNRVKELLP 134 Query 174 RIGALIDTVHRHHLASARTYFEGVIGDTSA---SVTCGIGFADLSSFTALTQALTPAQLQ 230 + L+ + R LA++ V+ D A +GFADL SFT L++ L +L Sbjct 135 DVERLLLHIWRRQLAASSARTLAVMSDNDAVPNYYPLVVGFADLVSFTTLSRELDEVELA 194 Query 231 DLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVR 290 ++ F+A D+V + GGR+VK +GD +++V+ SP A+ L VR Sbjct 195 GVVEGFEATAADIVASGGGRVVKTLGDEILYVADSPAEAADIALRLASGVKTHVEVPDVR 254 Query 291 AGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPAL 341 GLA G VL L+GD FG VN ++RL + A PG +L L + L + L Sbjct 255 VGLAAGPVLTLHGDVFGTTVNRSSRLTSFARPGTVLIDESLAESLAEEEGL 305 >gi|296137962|ref|YP_003645205.1| adenylate/guanylate cyclase [Tsukamurella paurometabola DSM 20162] gi|296026096|gb|ADG76866.1| adenylate/guanylate cyclase [Tsukamurella paurometabola DSM 20162] Length=337 Score = 122 bits (306), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 104/306 (34%), Positives = 149/306 (49%), Gaps = 29/306 (9%) Query 53 DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLT-VAGPDVPTLSQADVDALATWVA 111 D LL G YT A+ G+ +D+ W+ G + D ++ DV+ + A Sbjct 10 DELLLPGTREYTFRELAELGGMDIEDLRAWWTSAGFADLRDDDTKAFTRDDVEIVRDLAA 69 Query 112 LKA--LVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRA-- 167 L A +V D + LG AM RLAE ++ MIR H L ARA A Sbjct 70 LFADGVVDADAVVPGSQALGQAMYRLAEWQAPMIR---------HY---LEAARADDAPD 117 Query 168 ----AAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTC--GIGFADLSSFTALT 221 AA + R+ L + R HLA+A D +T +GFAD+ +T L+ Sbjct 118 PASGAALVIDRMDNLQAHIWRRHLAAATQRLMTPEADEEGDITATMAVGFADMVGYTRLS 177 Query 222 QALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLV---D 278 + L +L LL+ F+ + V++ GG ++K +GD VM+ + P R A++L D Sbjct 178 RGLAVPELSTLLSTFETRMRTVIYGGGGWIIKGVGDEVMFAADEPAAASRIALELQTPHD 237 Query 279 HPGARAAEL---QVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDML 335 +P A +L Q+R G+AYG VL GD FGN VNLAARL +AA PG +L QL + + Sbjct 238 YPELDAIDLEFPQLRVGMAYGEVLQRYGDLFGNVVNLAARLTSAARPGTVLVDGQLAEAI 297 Query 336 PDWPAL 341 D P L Sbjct 298 ADVPDL 303 >gi|119717714|ref|YP_924679.1| adenylate cyclase [Nocardioides sp. JS614] gi|119538375|gb|ABL82992.1| adenylate cyclase [Nocardioides sp. JS614] Length=335 Score = 122 bits (306), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 95/284 (34%), Positives = 142/284 (50%), Gaps = 13/284 (4%) Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATW--VALKALVGE 118 P + A G++ + R W LG G + + AD DAL+T V + Sbjct 29 PTFNAQEVAARTGVTVAEARRLWRALGFPEHGLET-AFTDADADALSTLLDVVASGAINF 87 Query 119 DGAFGLLRVLGTAMARLAEAE-STMIRAGSPNIQMTHTHDELATAR---AYRAAAEFVPR 174 D A L R +G MARLA+ E +T++ ++ DE +R A R E Sbjct 88 DMAVNLTRAVGQTMARLADWEVATLVH----RVEELEAGDEATGSREGSAIRLIDEINQP 143 Query 175 IGALIDTVHRHHLASARTYFEGVIGDTS--ASVTCGIGFADLSSFTALTQALTPAQLQDL 232 L+ V R HLA+A + E + + +V +GFAD+ SFTAL+ L+ ++ DL Sbjct 144 FEELLVYVWRRHLAAAVSRVEALRANEEDLNTVQLTVGFADIVSFTALSNRLSEERIGDL 203 Query 233 LTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAG 292 + F++ +DVV A GR++K IGD+V++V+ P R A +++ G VR G Sbjct 204 VELFESRCSDVVAAQRGRVIKSIGDSVLFVNDDPVRAYDTAEGIINVVGRDTRMPDVRLG 263 Query 293 LAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLP 336 LA G+V+ GD FG PVNLAARL A A +I+ + +LP Sbjct 264 LASGSVVMRLGDVFGPPVNLAARLTAVARRNRIIIDSATAGLLP 307 >gi|312141612|ref|YP_004008948.1| adenylate/guanylate cyclase [Rhodococcus equi 103S] gi|311890951|emb|CBH50270.1| putative adenylate/guanylate cyclase [Rhodococcus equi 103S] Length=345 Score = 120 bits (302), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 106/340 (32%), Positives = 163/340 (48%), Gaps = 22/340 (6%) Query 34 TVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTV-AG 92 TV ++Q+E L G GP YT A+ G+ + R W +G + A Sbjct 10 TVLGLIQSEVEQTLLG---------GPRRYTREQVAEIAGVPLERAQRLWVSMGFAIDAD 60 Query 93 PDVPTLSQADVDALATWVAL--KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAG-SPN 149 PD + AD AL V + +D A R LG +M+RLAE + ++ + + Sbjct 61 PDAAMFTDADAAALRGLVGFVDSGALAQDAAVAATRALGQSMSRLAEWQVAVLNSHLAEE 120 Query 150 IQMTHTHDELATARAYRAA-----AEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSAS 204 + TH RA R A + +P + AL V R HLA+A G +G+ + Sbjct 121 LAATHLDAGTLDERALRDAVGALTSGLLPTVEALQSYVWRRHLAAATARRAGSVGEDTTH 180 Query 205 VTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSS 264 T +GFAD+ +T+LT+ + +L LL +F++ T V+ GG ++K +GD VM+ + Sbjct 181 RTLVVGFADMVGYTSLTRRIRVDELGALLEDFESQTTSVITQGGGWVIKNVGDEVMFAAE 240 Query 265 SPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQ 324 R A+ L + + +R GLA G VL GD FG VN+AARL +AA PG Sbjct 241 HASDAARIALGLQEAARTHPEQPDLRVGLALGPVLVRFGDLFGEAVNIAARLTSAARPGT 300 Query 325 ILAAAQLRDMLPDWPAL---AHGPLTLKGFDAPVMAFELH 361 +L A+L L D + + PL ++G+ + + AF L Sbjct 301 VLVDAELSAALVDDDGVQLRSLRPLRVRGY-SRLRAFALR 339 >gi|300783495|ref|YP_003763786.1| adenylate cyclase [Amycolatopsis mediterranei U32] gi|299793009|gb|ADJ43384.1| adenylate cyclase [Amycolatopsis mediterranei U32] gi|340524881|gb|AEK40086.1| adenylate cyclase [Amycolatopsis mediterranei S699] Length=379 Score = 120 bits (300), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 92/307 (30%), Positives = 144/307 (47%), Gaps = 17/307 (5%) Query 55 LLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALAT--WVAL 112 +L G YT A++ G+ + R W LG D + ADV+A+ T + Sbjct 15 VLLGGRRKYTRLEVAEKAGVPDERSRRLWRALGFATVRDDEVVFTDADVEAMRTADQLVQ 74 Query 113 KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFV 172 L+ + R LG ++RLAE + M+ ++ EL R+ R V Sbjct 75 SGLIDPSIEVSVTRALGQHLSRLAEWQVDML------WELIRRQPELG--RSERQVTRLV 126 Query 173 ----PRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQ 228 P + + + V R HLA+ GD S T +GF D+ +T LT+ + + Sbjct 127 DGLLPELERVQNFVWRRHLAAYAGRAFAAAGDNVESRTEVVGFVDMVGYTRLTRQIGEDE 186 Query 229 LQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQ 288 L +L F+ T+V+ GR+VK IGD V++V+ +P A+ L + A Sbjct 187 LSRVLDAFETLATEVIAEHHGRVVKMIGDEVLFVADAPVDAAEIALTLTERTSADETLPA 246 Query 289 VRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPAL---AHGP 345 VRAG+A G +L+ GD +G+ VNLAARL + A PG IL +L L + A P Sbjct 247 VRAGMASGRILSRFGDVYGSVVNLAARLTSVARPGTILVDRELAGELAEEKAYELRTRRP 306 Query 346 LTLKGFD 352 +T++G++ Sbjct 307 VTVRGYN 313 >gi|325673132|ref|ZP_08152826.1| adenylate cyclase [Rhodococcus equi ATCC 33707] gi|325556385|gb|EGD26053.1| adenylate cyclase [Rhodococcus equi ATCC 33707] Length=345 Score = 119 bits (298), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 106/340 (32%), Positives = 162/340 (48%), Gaps = 22/340 (6%) Query 34 TVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTV-AG 92 TV ++Q+E L G GP YT A+ G+ + R W +G + A Sbjct 10 TVLGLIQSEVEQTLLG---------GPRRYTREQVAEIAGVPLERAQRLWVSMGFAIDAD 60 Query 93 PDVPTLSQADVDALATWVAL--KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAG-SPN 149 PD + AD AL V + +D A R LG +M+RLAE + ++ + + Sbjct 61 PDAAMFTDADAAALRGLVGFVDSGALAQDAAVAATRALGQSMSRLAEWQVAVLNSHLAEE 120 Query 150 IQMTHTHDELATARAYRAA-----AEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSAS 204 + TH RA R A + +P + AL V R HLA+A G G+ + Sbjct 121 LAATHLDAGTLDERALRDAVGALTSGLLPTVEALQSYVWRRHLAAATARRAGSAGEDTTH 180 Query 205 VTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSS 264 T +GFAD+ +T+LT+ + +L LL +F++ T V+ GG ++K +GD VM+ + Sbjct 181 RTLVVGFADMVGYTSLTRRIRVDELSALLEDFESQTTSVITQGGGWVIKNVGDEVMFAAE 240 Query 265 SPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQ 324 R A+ L + + +R GLA G VL GD FG VN+AARL +AA PG Sbjct 241 HASDAARIALGLQEAARTHPEQPDLRVGLALGPVLVRFGDLFGEAVNIAARLTSAARPGT 300 Query 325 ILAAAQLRDMLPDWPAL---AHGPLTLKGFDAPVMAFELH 361 +L A+L L D + + PL ++G+ + + AF L Sbjct 301 VLVDAELSAALVDDDGVQLRSLRPLRVRGY-SRLRAFALR 339 >gi|333921659|ref|YP_004495240.1| adenylate/guanylate cyclase [Amycolicicoccus subflavus DQS3-9A1] gi|333483880|gb|AEF42440.1| Adenylate/guanylate cyclase [Amycolicicoccus subflavus DQS3-9A1] Length=335 Score = 119 bits (298), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 89/272 (33%), Positives = 136/272 (50%), Gaps = 16/272 (5%) Query 63 YTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALV--GEDG 120 TLA +D G++A+ R W LG D + ADV ALA L+A GED Sbjct 27 MTLAELSDAAGVTAEQALRLWRALGFAEPAADEQVFTSADVQALAILARLEAGAKPGEDL 86 Query 121 AFGLLRVLGTAMARLAEAESTMI--RAGSPNIQMTHTHDELATARAYRAAAEFVPRIGAL 178 + LLR LG M+RLA + + RA N E A + R A +F+ Sbjct 87 SSSLLRALGHHMSRLASWQVIAMEDRAARRN--------EAGAAESVRTAMDFIADHIND 138 Query 179 IDTV----HRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLT 234 +D++ R L++ + G + + + + +GFAD+ SFT+L + L+ +L L+T Sbjct 139 LDSIVLYAWRRQLSAIAAWRLGRMSEDAQKLPLTVGFADMVSFTSLVRTLSADELARLVT 198 Query 235 EFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLA 294 F+ D+V + GR++K IGDA+++ + SP + A L + VR G+A Sbjct 199 RFELVAMDIVLRNRGRVIKMIGDAILFAADSPGQGADIATQLSAAISGQNDLPDVRVGMA 258 Query 295 YGTVLALNGDYFGNPVNLAARLVAAAAPGQIL 326 G V++ GD FG PVN+A+RL A PG +L Sbjct 259 TGEVVSRLGDIFGQPVNVASRLTEQADPGTVL 290 >gi|284046120|ref|YP_003396460.1| adenylate/guanylate cyclase [Conexibacter woesei DSM 14684] gi|283950341|gb|ADB53085.1| adenylate/guanylate cyclase [Conexibacter woesei DSM 14684] Length=373 Score = 118 bits (296), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 119/359 (34%), Positives = 169/359 (48%), Gaps = 30/359 (8%) Query 20 ERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDV 79 ER LL L G + E+ +A RL L + +L G YT A +GL + + Sbjct 24 ERIALLDRLVAEGVPLPELRRAAAEDRLALLQVERML--GTEEYTPREVAARVGLPVELI 81 Query 80 ARAWSLLGLTVAGPDVPTLSQADVDALATWVALKAL-VGEDGAFGLLRVLGTAMARLAEA 138 R LGL PD L+++D++ A A A + E G + RVLG +AR+A Sbjct 82 LRHRQALGLPRPDPDDRVLTESDIETAARLKAFHAAGLSEQGILEVSRVLGEGLARVAAT 141 Query 139 ESTMIRAG--SPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHRHHLASA-RTYFE 195 ++R P I D ATA +A+ P++G ++ + HL RT Sbjct 142 LRPLVRDTFLEPGIGERELSDRYATA-----SAQLGPQLGVVMQHILNMHLRDQLRTDVV 196 Query 196 G----VIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDL---LTEF--DAAVTDVVHA 246 G V G +V I FADL FT L + + +L + LTE +AA V Sbjct 197 GRAELVRGGVLGAVEMSIAFADLVGFTKLGERVPAEELGAIAGRLTELAVEAAQPPV--- 253 Query 247 DGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL-QVRAGLAYGTVLALNGDY 305 RLVK IGDAVM VS P+ L+ ++++V A E ++RAG+A G VL GD+ Sbjct 254 ---RLVKSIGDAVMLVSPDPDALLATSLEIVAAADAEGEEFPRLRAGVATGPVLGRAGDW 310 Query 306 FGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPALAHGPL---TLKGFDAPVMAFELH 361 +G+PVNLA+R+ A G ++AA RD A PL L+G D PV F + Sbjct 311 YGSPVNLASRITGVARSGSVVAAGATRDAATASDRWAWSPLPARRLRGVDHPVPLFRVR 369 >gi|271962871|ref|YP_003337067.1| adenylate cyclase [Streptosporangium roseum DSM 43021] gi|270506046|gb|ACZ84324.1| Adenylate cyclase [Streptosporangium roseum DSM 43021] Length=330 Score = 118 bits (295), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 97/295 (33%), Positives = 143/295 (49%), Gaps = 14/295 (4%) Query 55 LLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALK- 113 L P +T A+ G+ D R W LG D + ADV AL A+ Sbjct 18 LFVGASPRHTRVQVAEVAGVPQDLAERIWRALGFATLADDAVAFTDADVAALERVRAMME 77 Query 114 -ALVGEDGAFGLLRVLGTAMARLAEAESTMIRAG--SPNIQMTHTHDELATARAYRAAAE 170 L+ + + R LG ARLA+ ++ ++ P+ Q T + A A A Sbjct 78 GGLLDDQTVVRMARALGQTTARLAQWQAEIMIGAMLEPDQQPT----DAALAAILDTAHR 133 Query 171 FVPRIGALIDTVHRHHLASARTYFEGVIGDTSASV----TCGIGFADLSSFTALTQALTP 226 +P ++ V R LA+A T + T V T +GFADL SFT +++ L Sbjct 134 LLPDFEQVLIHVWRAQLAAAGTRLLAITDLTEEIVPTRLTLAVGFADLVSFTQVSRELDE 193 Query 227 AQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAE 286 L +L+ F++ +DVV A GGR+VK +GD V++ ++ P A++LV+ R Sbjct 194 RALAELVEGFESRASDVVAAHGGRMVKTLGDEVLFTAADPRTAALIALELVE--AIRRDG 251 Query 287 LQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPDWPAL 341 +VR GLAYG VL + GD FG VNLAARL A A PG I+ +L + + + P + Sbjct 252 PEVRIGLAYGPVLPVMGDVFGTTVNLAARLTAIARPGTIIVDGELAEAVGETPGV 306 >gi|326333791|ref|ZP_08200024.1| adenylate cyclase [Nocardioidaceae bacterium Broad-1] gi|325948373|gb|EGD40480.1| adenylate cyclase [Nocardioidaceae bacterium Broad-1] Length=316 Score = 117 bits (293), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 92/287 (33%), Positives = 142/287 (50%), Gaps = 13/287 (4%) Query 60 PPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDAL--ATWVALKALVG 117 P T A A++ G+S D R W LG G +ADV AL A +A LV Sbjct 7 PVNLTSAEVAEKAGVSLDQAKRLWRALGFPEIGDTEAFFDEADVHALSKANEIAGNGLVS 66 Query 118 EDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRA----AAEFVP 173 D L R +G +MARL++ E + A +++ T DE + + +A + +F Sbjct 67 FDLVVNLTRGIGQSMARLSDYE---VSALLHHVE-TQNEDERSPSELLKATVSVSEQFES 122 Query 174 RIGALIDTVHRHHLASARTYFEGVIG---DTSASVTCGIGFADLSSFTALTQALTPAQLQ 230 ++ R H+ +A E I + +V +GFAD+ SFTAL+ LT ++ Sbjct 123 AFEEMMIFAWRRHMRAALARAEASIAGPEEQLGTVWQTVGFADIVSFTALSNTLTEEKIG 182 Query 231 DLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVR 290 DL+ F++ DVV GGR++K +GD+V++V+ P + A +++ G VR Sbjct 183 DLVELFESRCADVVATWGGRIIKSLGDSVLFVNDDPLQAYGTAEGIINVIGRDPRMPDVR 242 Query 291 AGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPD 337 GLA G V++ GD FG PVN+AARL A A +I+ +P+ Sbjct 243 VGLASGNVVSRLGDVFGPPVNMAARLTAVARRNRIIVDEATAGTMPE 289 >gi|302524847|ref|ZP_07277189.1| adenylate cyclase [Streptomyces sp. AA4] gi|302433742|gb|EFL05558.1| adenylate cyclase [Streptomyces sp. AA4] Length=357 Score = 116 bits (290), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 97/332 (30%), Positives = 151/332 (46%), Gaps = 17/332 (5%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDAL--ATWVALK 113 L GP YT A+ G+ + R W LG D + ADV+A+ A + Sbjct 5 LLGGPRRYTRLEVAERAGVPEERSRRLWRALGFATVEDDEVVFTDADVEAMRIADGLVSS 64 Query 114 ALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATA--RAYRAAAEF 171 L+ + R LG ++RLAE + M+ ++ + ELA + + R Sbjct 65 GLIAPGMEVAVTRALGQHLSRLAEWQVHML------WELITENPELARSDRQVTRLVERL 118 Query 172 VPRIGALIDTVHRHHLAS-ARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQ 230 +P + + V R HLA+ A F D +GF D+ +T T+ +L Sbjct 119 LPELEQVQSYVWRRHLAAFAGRAFASPDEDLETRALV-VGFVDMVGYTRFTREADEEELT 177 Query 231 DLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVR 290 +L F++ T+V+ GR+VK IGD V++V+ +P A+ L + G VR Sbjct 178 QVLDGFESLATEVIAEHHGRVVKMIGDEVLFVADTPADGAEIALTLAERTGEDGDLPAVR 237 Query 291 AGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLR---DMLPDWPALAHGPLT 347 AG+A G VL+ GD +G+ VNLAARL +AA PG +L +L + LP + P+ Sbjct 238 AGMASGRVLSRFGDVYGSVVNLAARLTSAARPGTVLVDRELAGELESLPQFDLRTRRPIA 297 Query 348 LKGFD--APVMAFELHDNPRARDADTPSPAAS 377 ++G++ P D P R A + AA Sbjct 298 VRGYNRLRPSALRRAKDKPTGRFASSQELAAE 329 >gi|284028309|ref|YP_003378240.1| adenylate/guanylate cyclase [Kribbella flavida DSM 17836] gi|283807602|gb|ADB29441.1| adenylate/guanylate cyclase [Kribbella flavida DSM 17836] Length=367 Score = 115 bits (289), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 93/286 (33%), Positives = 136/286 (48%), Gaps = 26/286 (9%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKAL 115 L G +T ++ G+S + R W LG D + DV+AL AL Sbjct 61 LLGGERKFTRRQVSERAGISTERAERMWRALGFATVPDDELAFTDDDVEALRLVAAL--- 117 Query 116 VGEDGAF-------GLLRVLGTAMARLAEAESTMIR---AGSPNIQMTHTHDELATARAY 165 ED F L R LG +RLA +S M AG+ +L A Sbjct 118 --EDDNFIDPAIESSLARKLGQTQSRLASWQSAMFLEFLAGA----------KLPADEAI 165 Query 166 RAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALT 225 A +P + L V R HLA+A + + + C +GFAD+ S+T LT+ L+ Sbjct 166 EVAGLLLPAMERLQTYVWRRHLAAAAGRAVAGSDELARGIRC-VGFADIVSYTRLTRRLS 224 Query 226 PAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAA 285 A L +L+ F+ DVV +GGR++K IGD V++V+ + + A+ L D A Sbjct 225 EAGLGELIERFEGMAADVVALNGGRVIKSIGDEVLFVTDTAAQGAAVALALQDEVAATEG 284 Query 286 ELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQL 331 ++R GLAYG++L GD +G VNLAARL + PG++LA +L Sbjct 285 LPELRIGLAYGSILIRLGDVYGETVNLAARLTSECKPGRVLADREL 330 >gi|72162951|ref|YP_290608.1| adenylate cyclase [Thermobifida fusca YX] gi|71916683|gb|AAZ56585.1| adenylate cyclase [Thermobifida fusca YX] Length=336 Score = 115 bits (289), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 95/292 (33%), Positives = 139/292 (48%), Gaps = 14/292 (4%) Query 53 DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL 112 + +L G YT G S + AR W LG DVP + +DV+A+ L Sbjct 11 EAVLMGGEARYTRDEVVRLAGTSPEFAARIWRALGFAAREDDVPAYTDSDVEAMRVTARL 70 Query 113 --KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAE 170 L+ E+ + L R +G M RLAE +++++ S ++ T L A E Sbjct 71 IRDGLLTEEASIRLARAMGQTMIRLAEWQTSILTTLSYKPEV-DTDGHLGPLVGL--AKE 127 Query 171 FVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVT-----CGIGFADLSSFTALTQALT 225 +P + L+ V R L +A + V S + +GFADL SFT L++ L Sbjct 128 LLPDMETLLLHVWRRQLVAAVSRSLAVQEQQSEDASPHYFPLIVGFADLVSFTTLSRELD 187 Query 226 PAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAA 285 L D++ F+A D+V + GGR+VK +GD +++V+ A+ L Sbjct 188 EVALADVVEGFEATSADIVASCGGRIVKTLGDEILYVADDARSAADIALQLAAGVKTHVE 247 Query 286 ELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILA----AAQLRD 333 VR G+AYG VLAL GD FG VN A+RL + A PG +L AAQL+D Sbjct 248 VPDVRVGVAYGPVLALLGDVFGTTVNRASRLTSFARPGTVLIDEALAAQLKD 299 >gi|269128322|ref|YP_003301692.1| adenylate/guanylate cyclase [Thermomonospora curvata DSM 43183] gi|268313280|gb|ACY99654.1| adenylate/guanylate cyclase [Thermomonospora curvata DSM 43183] Length=348 Score = 114 bits (286), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 89/287 (32%), Positives = 137/287 (48%), Gaps = 15/287 (5%) Query 55 LLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL-- 112 LL G Y A G++ + R W LG D + D+DAL L Sbjct 30 LLLGGELRYNRVDAIRLGGVTKEFSQRLWRALGYPHLSDDAVAFTDRDIDALCQLRRLMD 89 Query 113 KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEF- 171 + ++ EDG L+R G M RLAE + ++ + + ++ E T + RA AE Sbjct 90 EGVLDEDGVIRLVRAFGQTMTRLAEWQVDLLTSLTGQDEL-----EPPTPESLRALAELA 144 Query 172 ---VPRIGALIDTVHRHHLASA---RTYFEGVIGDTSASVTCG-IGFADLSSFTALTQAL 224 + + L+ R LA+A G++ A+ +GFAD+ SFT +++ L Sbjct 145 EKHIDELEPLVVHAWRRQLAAAGTRALALAATAGESDATRPLATVGFADMVSFTQMSREL 204 Query 225 TPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARA 284 +L ++ F+ DVV + GGRL+K +GD V++ + SPE A+ + + Sbjct 205 EEPELARVVERFEETTADVVASRGGRLIKTLGDEVLFSADSPELGGEIALSIAEAIKDET 264 Query 285 AELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQL 331 VR G+AYG VL + GD FG VNLAARL + A PG ++ A+L Sbjct 265 EMPDVRVGVAYGPVLPMRGDVFGTTVNLAARLTSIARPGTVVIDAEL 311 >gi|111018939|ref|YP_701911.1| adenylate cyclase [Rhodococcus jostii RHA1] gi|110818469|gb|ABG93753.1| probable adenylate cyclase [Rhodococcus jostii RHA1] Length=400 Score = 114 bits (284), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 119/352 (34%), Positives = 172/352 (49%), Gaps = 28/352 (7%) Query 21 RAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVA 80 R G+L L E G +++E+ A R RL L + L + Y + +++ G++ +D Sbjct 55 RMGVLNTLIEDGVSIDELRAASRNNRLAHLLLEHAL-APKGRYGIDEISEKTGVTVEDAR 113 Query 81 RAWSLLGLTVAGPDVPTLSQADVDALATWVALKAL-VGEDGAFGLLRVLGTAMARLAEAE 139 R + +G A D D+D + L + E G F RVLG + +A+A Sbjct 114 RWFRAIGRG-ASEDGTFYDDGDLDLARGLKQYRDLGLDESGIFAAARVLGRNLWTVADAA 172 Query 140 STMIRAGSPNIQMTHTHDELATARAY--RAAAEFVPRIGA-LIDTVHRHHLASARTYFEG 196 +++ ++ T H E+A A R A+F +I A LI T RH L R+ G Sbjct 173 DALLQE---RLEATRDHPEVALRYAVEVRRIADFEAQILAHLIATTLRHQL---RSDAVG 226 Query 197 VIGDTSASV----TCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLV 252 + D++ V G+ FADL FT L + + PA L + D TD+V RLV Sbjct 227 IARDSNLQVRGAQEIGVCFADLVGFTLLGEQVAPADLGRVAERLDGLATDLVLPPV-RLV 285 Query 253 KFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQ-VRAGLAYGTVLALNGDYFGNPVN 311 K IGDAVM VS P L A+DLV ARA L +RAG+A+GT + GD+FG PVN Sbjct 286 KTIGDAVMLVSPDPNALAYTALDLVQ--AARAEGLPPLRAGIAWGTAVPSAGDWFGRPVN 343 Query 312 LAARLVAAAAPGQILAAAQLRDMLPD---W--PALAHGPLTLKGFDAPVMAF 358 +A+R+VA A +++ + D L W PA +H LKG D P F Sbjct 344 MASRVVAVAPSHEVVVTGEFYDELDTDEFWGEPAGSH---RLKGIDVPQELF 392 >gi|296395295|ref|YP_003660179.1| adenylate/guanylate cyclase [Segniliparus rotundus DSM 44985] gi|296182442|gb|ADG99348.1| adenylate/guanylate cyclase [Segniliparus rotundus DSM 44985] Length=371 Score = 113 bits (282), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 100/325 (31%), Positives = 152/325 (47%), Gaps = 25/325 (7%) Query 44 RGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGL-TVAGPDVPTLSQAD 102 R RL D LL G Y A+ +G+ +AR W G T P++ + D Sbjct 39 RARLRERVRDRLL-GGEHKYNRREIAELIGVEPYRIARLWVAFGFATDPDPEMKMFTDGD 97 Query 103 VDALATWVAL--KALVGEDGAFGLLRVLGTAMARLAE--AESTMIRAGSPNIQMTHTHDE 158 + AL + L + L+ D + + R LG + AR+AE AE+ R + ++ E Sbjct 98 LQALRLFTTLVDRGLLDPDMEYTVARNLGQSFARIAEWQAETAYERIRAEAVKRMPEGAE 157 Query 159 -----LATARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFAD 213 L+ A E +P + + R HLA+ G +GFAD Sbjct 158 ADVVALSGTLAGALLDEVLPAFDFVQSYLWRRHLAANAQRVGG-----QGEHKFAVGFAD 212 Query 214 LSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAA 273 + +T LT++L +L LL F++ T V+ +GG LVK +GD VM+ S+SP+ R A Sbjct 213 MVGYTRLTRSLDEPELDRLLESFESTATTVITQEGGWLVKTLGDEVMFASASPQAAARIA 272 Query 274 VDLVDH--PGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQL 331 + L+D G EL+V G+AYG VL GD +G VN+A+RL +A PG +L A L Sbjct 273 LTLLDFVPDGEEVPELRV--GVAYGRVLTRFGDLYGPTVNIASRLTTSAKPGSVLIDAGL 330 Query 332 RDMLPDWPALAHGPLTLKGFDAPVM 356 + + + G L +K P+ Sbjct 331 AEEV-----VEEGDLQIKPLRRPLQ 350 >gi|134098563|ref|YP_001104224.1| adenylate cyclase [Saccharopolyspora erythraea NRRL 2338] gi|133911186|emb|CAM01299.1| adenylate cyclase [Saccharopolyspora erythraea NRRL 2338] Length=325 Score = 112 bits (280), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 92/305 (31%), Positives = 142/305 (47%), Gaps = 13/305 (4%) Query 53 DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL 112 + +L GP +T A A E G+ R W +G D + ADV AL V L Sbjct 16 ETVLLGGPARHTKADVAREAGVELRRAERLWQAMGFAHVDDDAVVFTDADVAALRRLVQL 75 Query 113 KA--LVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAE 170 + ++ + + R LG AM+RLAE + + R + +LAT + A Sbjct 76 VSAQVLTPEAETAVARSLGQAMSRLAEWQVGIFR----TVLGDDFSGDLATTAQF--AGA 129 Query 171 FVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQ 230 +P + L V R HL + G T IGFAD+ +T L + T +L Sbjct 130 IMPVMEQLQGYVWRRHLTATAMRELGGRDTGEDERTLVIGFADIVGYTRLIRDFTELELA 189 Query 231 DLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVR 290 L+ +F+ T VV + GR++K +GD V++V+ + A+ L + +R Sbjct 190 SLIDDFEELATGVVAENRGRIIKTVGDEVLFVTDTAADAAEVALSLNEQIAESTRLPPLR 249 Query 291 AGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQIL----AAAQLRDMLPDWPALAHGPL 346 GLA G VLA GD +G+ VN+A+RL + A P +L + LRD PD+ ++ GP Sbjct 250 IGLAKGVVLARFGDVYGSTVNIASRLTSVARPASVLVDREVSGSLRDH-PDYHLVSVGPT 308 Query 347 TLKGF 351 ++GF Sbjct 309 KVQGF 313 >gi|317509276|ref|ZP_07966897.1| adenylate and Guanylate cyclase catalytic domain-containing protein [Segniliparus rugosus ATCC BAA-974] gi|316252486|gb|EFV11935.1| adenylate and Guanylate cyclase catalytic domain-containing protein [Segniliparus rugosus ATCC BAA-974] Length=359 Score = 112 bits (280), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 101/337 (30%), Positives = 164/337 (49%), Gaps = 22/337 (6%) Query 44 RGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGL-TVAGPDVPTLSQAD 102 R L G D LL G Y A+ +G+ +AR W G T P+V + D Sbjct 26 RRTLRGQVQDRLL-GGERKYNRREIAELIGVQPYRIARLWVAFGFATDPDPEVKMFTDGD 84 Query 103 VDALATWVAL--KALVGEDGAFGLLRVLGTAMARLAE--AESTMIRAGSPNI-QMTHTHD 157 + AL + L + L+ + + + R LG + AR+AE AE+T R + + ++ D Sbjct 85 LQALRLFTTLVDRDLLAPEMEYTVARNLGQSFARIAEWQAETTYDRIRAAALARLPEGAD 144 Query 158 E-----LATARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFA 212 E L+ A E +P + + R HLA+ + V G T + +GFA Sbjct 145 EAEVVTLSGKLAGTLLDEVLPAFDFVQSYLWRRHLAAN---AQRVGGQTEHKL--AVGFA 199 Query 213 DLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRA 272 D+ +T LT++L +L LL F++ T V+ +GG +VK +GD +M+ ++SP+ R Sbjct 200 DMVGYTRLTRSLDERELGRLLESFESTATTVITQEGGWVVKTLGDEIMFAAASPQSAARI 259 Query 273 AVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLR 332 A++L D Q+R G+AYG VL GD +G VN+A+RL +A PG +L +L Sbjct 260 ALELQDFVPDGEDVPQLRVGVAYGKVLTRFGDLYGPTVNIASRLTTSAKPGGVLIDGELA 319 Query 333 DMLPDWPALA----HGPLTLKGFDAPVMAFELHDNPR 365 + + + + PL ++G+ + A+ L PR Sbjct 320 EEIVEEHDMHIKPLRRPLQVRGYRR-LDAYALQWRPR 355 >gi|291003220|ref|ZP_06561193.1| adenylate cyclase [Saccharopolyspora erythraea NRRL 2338] Length=317 Score = 112 bits (280), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 92/305 (31%), Positives = 142/305 (47%), Gaps = 13/305 (4%) Query 53 DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL 112 + +L GP +T A A E G+ R W +G D + ADV AL V L Sbjct 8 ETVLLGGPARHTKADVAREAGVELRRAERLWQAMGFAHVDDDAVVFTDADVAALRRLVQL 67 Query 113 KA--LVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAE 170 + ++ + + R LG AM+RLAE + + R + +LAT + A Sbjct 68 VSAQVLTPEAETAVARSLGQAMSRLAEWQVGIFR----TVLGDDFSGDLATTAQF--AGA 121 Query 171 FVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQ 230 +P + L V R HL + G T IGFAD+ +T L + T +L Sbjct 122 IMPVMEQLQGYVWRRHLTATAMRELGGRDTGEDERTLVIGFADIVGYTRLIRDFTELELA 181 Query 231 DLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVR 290 L+ +F+ T VV + GR++K +GD V++V+ + A+ L + +R Sbjct 182 SLIDDFEELATGVVAENRGRIIKTVGDEVLFVTDTAADAAEVALSLNEQIAESTRLPPLR 241 Query 291 AGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQIL----AAAQLRDMLPDWPALAHGPL 346 GLA G VLA GD +G+ VN+A+RL + A P +L + LRD PD+ ++ GP Sbjct 242 IGLAKGVVLARFGDVYGSTVNIASRLTSVARPASVLVDREVSGSLRDH-PDYHLVSVGPT 300 Query 347 TLKGF 351 ++GF Sbjct 301 KVQGF 305 >gi|326329339|ref|ZP_08195664.1| adenylate cyclase [Nocardioidaceae bacterium Broad-1] gi|325952914|gb|EGD44929.1| adenylate cyclase [Nocardioidaceae bacterium Broad-1] Length=312 Score = 111 bits (277), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 88/269 (33%), Positives = 133/269 (50%), Gaps = 11/269 (4%) Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKAL--VGE 118 P T A A +G+ + W LG AG D ++ADV+AL L L + E Sbjct 11 PTLTRADVAGAVGVPMEVAEDLWHHLGFPHAGDDEIAFTEADVEALRMTQELVRLGVLSE 70 Query 119 DGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGAL 178 D L+R G + ARLAE +++++ + DE+ A A+ +P + +L Sbjct 71 DRQAALVRTWGRSYARLAEWQTSLL----AEVARERGGDEVEDLVAL--TAQVLPLVESL 124 Query 179 IDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDA 238 D V R HL SA + D SA V +GF D+ +TA ++ L+ +L D + EF+ Sbjct 125 QDYVWRRHLVSAARRML-TVADASA-VPLAVGFLDIVGYTARSKRLSDKELVDWVEEFED 182 Query 239 AVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL-QVRAGLAYGT 297 +DVV GGR++K++GD V + R A++L R + VRAG++YG Sbjct 183 TCSDVVVEHGGRVIKYLGDGVFFTFEDVPSAARTALELAALGEDRDSAFPHVRAGISYGD 242 Query 298 VLALNGDYFGNPVNLAARLVAAAAPGQIL 326 V+ GD FG VN+AARL A P ++ Sbjct 243 VVLRLGDVFGPTVNIAARLTTVARPSSVV 271 >gi|226361039|ref|YP_002778817.1| adenylate cyclase [Rhodococcus opacus B4] gi|226239524|dbj|BAH49872.1| putative adenylate cyclase [Rhodococcus opacus B4] Length=383 Score = 110 bits (275), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 121/361 (34%), Positives = 173/361 (48%), Gaps = 30/361 (8%) Query 14 GIANPRE--RAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADE 71 G++ P R G+L L E G +++++ A R RL L + L S Y++ A + Sbjct 29 GLSGPDRSARMGVLNTLIEDGASIDDLRGAARGDRLAHLLLEHAL-SPKGRYSIDDIARK 87 Query 72 LGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKAL-VGEDGAFGLLRVLGT 130 +G++ DD R + +G A D D+D + L + E F RVLG Sbjct 88 VGVTVDDARRWFRAIGRG-ASSDGTFYDDGDLDLARGLEQYRDLGLDESAIFAAARVLGR 146 Query 131 AMARLAEAESTMIRAGSPNIQMTHTHDELATARAY--RAAAEFVPRIGA-LIDTVHRHHL 187 + +A A ++++ ++ T H E+A A R +F +I A LI T RH L Sbjct 147 NLWTVAGAADSLLQ---ERLEATREHPEVALRYAVEVRRIVDFEAQILAHLIATALRHQL 203 Query 188 ASARTYFEGVIGDTSASV----TCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDV 243 R+ G+ GD++ V G+ FADL FT L + PA L + D TD+ Sbjct 204 ---RSDAVGIAGDSNLRVRGAQEVGVCFADLVGFTLLGEQAAPADLGRVAERLDRVATDL 260 Query 244 VHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL-QVRAGLAYGTVLALN 302 V RLVK IGDAVM VS P L A+DLV AR L Q+RAG+A+GT + Sbjct 261 VSPPV-RLVKTIGDAVMMVSPDPNALAHVALDLVQ--AARTEGLPQLRAGIAWGTAVPSA 317 Query 303 GDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPD---W--PALAHGPLTLKGFDAPVMA 357 GD+FG PV A R+VA A +++ + D L W PA +H L+G DAP Sbjct 318 GDWFGRPVGTAGRVVAVAPSQEVVVTGEFYDELDSDEFWGEPAGSH---QLEGIDAPQKL 374 Query 358 F 358 F Sbjct 375 F 375 >gi|119714431|ref|YP_921396.1| adenylyl cyclase class-3/4/guanylyl cyclase [Nocardioides sp. JS614] gi|119535092|gb|ABL79709.1| adenylyl cyclase class-3/4/guanylyl cyclase [Nocardioides sp. JS614] Length=371 Score = 108 bits (269), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 93/275 (34%), Positives = 133/275 (49%), Gaps = 10/275 (3%) Query 55 LLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKA 114 LL P T A+ GL + + W LLG PD ++ADV+AL L Sbjct 4 LLLGALPHLTRGEVAERAGLPIEVAEQLWRLLGFARTAPDDLAFTEADVEALRLTRELIE 63 Query 115 L--VGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFV 172 L +G D L+R G + ARLAE +++++ +I + D R A + Sbjct 64 LGILGPDSQAALVRTWGRSYARLAEWQTSLL----ADIAVA---DADPGRRLTELAESVL 116 Query 173 PRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDL 232 PR+ AL V R HLASA + + F D+ +T+ ++AL A+L Sbjct 117 PRVEALQSYVWRRHLASATGRALAAESAAAPVSPLAVCFVDIVGYTSRSKALDQAELVGW 176 Query 233 LTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL-QVRA 291 L +F+ A T VV GGR++K IGD V++V+ AA+ L A VRA Sbjct 177 LEQFEDAATGVVVDHGGRIIKTIGDEVLFVADRAADAAEAALRLTARGSDEADPFPAVRA 236 Query 292 GLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQIL 326 G+AYG V++ GD FG VN+AARL + A PG +L Sbjct 237 GIAYGDVVSRLGDVFGPTVNVAARLTSLARPGTVL 271 >gi|311743182|ref|ZP_07716990.1| adenylate cyclase [Aeromicrobium marinum DSM 15272] gi|311313862|gb|EFQ83771.1| adenylate cyclase [Aeromicrobium marinum DSM 15272] Length=329 Score = 107 bits (267), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 93/269 (35%), Positives = 133/269 (50%), Gaps = 8/269 (2%) Query 63 YTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVA--LKALVGEDG 120 YT A A+ G+ + R W LG G V ADV A+ + A + ++ +D Sbjct 21 YTTAQVAERGGVGPEQAQRLWRALGFPDPGETV-AFGDADVRAIRSVQAGIEQGVLEDDT 79 Query 121 AFGLLRVLGTAMARLAEAE-STMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALI 179 L R LG MA+LA+ E ST+I ++ L RA A P L+ Sbjct 80 TVRLTRALGQTMAKLADWEVSTLIDQLERDVGAGRAGSRLE--RATWLAQHAAPVFEELM 137 Query 180 DTV--HRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFD 237 V A+AR G + S+ +GFADLS FT+L+ +L L L+ F+ Sbjct 138 LHVWRRHLAAAAARLEALGAADEELLSMQMTVGFADLSRFTSLSNSLDDNDLAALVERFE 197 Query 238 AAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYGT 297 D++ A GGR++K +GDA+++VS P R A+DLV G+R +R GLA G+ Sbjct 198 ERCADLITAQGGRVIKTLGDAILYVSPDPCGATRTALDLVAQVGSRDDLPAIRVGLATGS 257 Query 298 VLALNGDYFGNPVNLAARLVAAAAPGQIL 326 V++ GD FG PVNLAARL A ++L Sbjct 258 VISRLGDVFGPPVNLAARLSHVARSNRVL 286 >gi|320532578|ref|ZP_08033383.1| adenylate and Guanylate cyclase catalytic domain protein [Actinomyces sp. oral taxon 171 str. F0337] gi|320135206|gb|EFW27349.1| adenylate and Guanylate cyclase catalytic domain protein [Actinomyces sp. oral taxon 171 str. F0337] Length=382 Score = 106 bits (265), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 89/294 (31%), Positives = 125/294 (43%), Gaps = 31/294 (10%) Query 53 DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL 112 + LL PP TL A G S + + W +G PD ++ DV AL VAL Sbjct 51 EYLLLGTPPSLTLTEVAQRAGTSVEVAQKFWRAMGFADVKPDAVHFTEQDVAALRDTVAL 110 Query 113 -----KALVGEDGAFGLLRVLGTAMARLAEAE-STMIRAGSPNIQMTHTHDELATARAYR 166 + + LLR M RL E T + S + + T L Sbjct 111 LDETSDSSLASASVLELLRAQSYTMDRLVLWELETFVTDLSERLGLDDTSARLVA----- 165 Query 167 AAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSASVTC---------------GIGF 211 + RI L++ + R R + ++G T A V+ +GF Sbjct 166 -----LDRIDGLVELLERQLTYVWRRHMASILGRTDAEVSTRGREDTGPDLYPLIRSLGF 220 Query 212 ADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVR 271 D+ SFT Q ++ A L +L F+ DV+ + G R+VK IGDAVM++S Sbjct 221 VDIVSFTQRAQGMSKAALTHMLEGFENTARDVITSRGARVVKTIGDAVMYISDDLLIAAD 280 Query 272 AAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQI 325 LVD ++VRA L G V++ +GD FG VNLA+RLV AA PG I Sbjct 281 VVTALVDELQKGPDAIRVRASLVEGRVISRSGDVFGPTVNLASRLVDAAEPGSI 334 >gi|269795825|ref|YP_003315280.1| family 3 adenylate cyclase [Sanguibacter keddieii DSM 10542] gi|269098010|gb|ACZ22446.1| family 3 adenylate cyclase [Sanguibacter keddieii DSM 10542] Length=362 Score = 106 bits (264), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 97/309 (32%), Positives = 143/309 (47%), Gaps = 35/309 (11%) Query 41 AERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQ 100 A +G G A D L GP TL A++ LS + + W LGL + GP+ + ++ Sbjct 22 ASSQGSDHGRALDAALLGGPRALTLDELAEKTSLSHEFLGTYWQALGLPILGPEQASFTE 81 Query 101 ADVDALATWVALKALVGEDGAFG------LLRVLGTAMARLAEAESTMIRAGSPNIQMTH 154 D AL A +GE L+R +G RLA ++ + ++ Sbjct 82 DDAQALRDIAA----IGESEQLSTRSLTTLVRSVGHTTERLALWQAEAL------VEHMA 131 Query 155 THDELATARAYRAAAEFVPRIGALIDT--VH--RHHLASARTYFEGVIGDTSASVTCG-- 208 + EL A E +P + +++ VH R LA+ + D A G Sbjct 132 SRYELDDTSARLLVLERLPSLAPVLEAQLVHAWRRQLAALAGRWSVEFSDARAVDETGAG 191 Query 209 -------IGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMW 261 +GFAD+ SFT T L ++L D +++F+A DV+ A GGR+VK IGDAV++ Sbjct 192 ELPLPRAVGFADIVSFTTRTAKLRSSELSDFVSDFEAGARDVITAAGGRVVKTIGDAVLF 251 Query 262 VSSSPERLVRAAVDLVDHPGARAAELQ----VRAGLAYGTVLALNGDYFGNPVNLAARLV 317 ++ + A+ L R EL+ VR L +G VL+ GD FG VNLAARL Sbjct 252 IADDVRTGAQVALGLAR--AGRDGELENVPPVRVSLVWGRVLSRFGDVFGPSVNLAARLT 309 Query 318 AAAAPGQIL 326 A A PG +L Sbjct 310 AEADPGTVL 318 >gi|334336517|ref|YP_004541669.1| adenylate/guanylate cyclase [Isoptericola variabilis 225] gi|334106885|gb|AEG43775.1| adenylate/guanylate cyclase [Isoptericola variabilis 225] Length=358 Score = 106 bits (264), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 94/301 (32%), Positives = 138/301 (46%), Gaps = 23/301 (7%) Query 42 ERRGRLFGLAG--DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLS 99 E R R+ +A D + GP YTL + GLS + + W LGL V P P + Sbjct 22 EERARVADVAARLDEEILGGPRRYTLDELVEGTGLSHEFIQSYWRWLGLPVTHPTDPWFT 81 Query 100 QADVDALATWVAL--KALVGEDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHD 157 AD++AL L A + E L+R LG RLA + +++ D Sbjct 82 DADMEALREIGDLVEDARLDERAQMTLIRALGHTTDRLALWQVEAF------VELVSRRD 135 Query 158 ELATARAYRAAAEFVP----RIGALIDTVHRHHLASAR----TYFEGVIGDTSAS----V 205 L A +A +P R+ ++ R LA+ F G G+T ++ + Sbjct 136 GLDDPHARQAVLHQIPHLADRLSHQLEHAWRRQLAALTGRLAIEFGGEQGETVSADQLPL 195 Query 206 TCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSS 265 +GFAD+ SFT T L +L + + F++ DV+ GGR+VK IGDAV++V+ Sbjct 196 RRAVGFADIVSFTKRTAGLGSQELAEFVQRFESRARDVIVEAGGRVVKTIGDAVLFVADD 255 Query 266 PERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQI 325 A+ L P A E+ VR G +G VL+ GD FG VNLA+R+ A P + Sbjct 256 VTTGAEVALGLA-APHATEEEIPVRVGFVWGRVLSRFGDVFGPDVNLASRITELAEPATV 314 Query 326 L 326 L Sbjct 315 L 315 >gi|227497918|ref|ZP_03928098.1| adenylate cyclase [Actinomyces urogenitalis DSM 15434] gi|226832654|gb|EEH65037.1| adenylate cyclase [Actinomyces urogenitalis DSM 15434] Length=343 Score = 104 bits (260), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 90/294 (31%), Positives = 127/294 (44%), Gaps = 32/294 (10%) Query 61 PIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKAL----- 115 P TL A E G + R W +G A PD ++ADV+AL + L Sbjct 6 PSLTLQQVAQEAGTGVELARRFWRAMGFADAQPDAVRFTEADVEALRALAEVVGLGGQAS 65 Query 116 ------VGEDGAFG---------LLRVLGTAMARLAEAE-STMIRAGSPNIQMTHTHDEL 159 VG GA G +LR M RL + T++ S Q D Sbjct 66 QDGSGCVGGQGAVGGLATSSALEMLRAQSYTMDRLVLWQLETLV---SDVAQRYDLDDTS 122 Query 160 ATARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVIGDTSAS--------VTCGIGF 211 A A E + + +D V R HL + + E + +T +GF Sbjct 123 ARLVALDRIEELLEPLRTQLDYVWRRHLTALLSRTESEVAKRGKEEAGPDLYPLTRSLGF 182 Query 212 ADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVR 271 D+ SFT Q + +L+ +LT+F+ DVV + G R+VK IGDAVM+++ Sbjct 183 VDIVSFTQRAQTMGRTELETMLTDFENTARDVVTSRGARVVKTIGDAVMYIADDVTTAAG 242 Query 272 AAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQI 325 LV+ ++VRA L G V++ +GD FG PVNLA+RLV A PG I Sbjct 243 VVTALVEELQRGPEMIRVRASLVQGRVVSRSGDVFGPPVNLASRLVDTAEPGGI 296 >gi|340360749|ref|ZP_08683214.1| hypothetical protein HMPREF9062_2339 [Actinomyces sp. oral taxon 448 str. F0400] gi|339882941|gb|EGQ72821.1| hypothetical protein HMPREF9062_2339 [Actinomyces sp. oral taxon 448 str. F0400] Length=362 Score = 103 bits (258), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 95/302 (32%), Positives = 134/302 (45%), Gaps = 31/302 (10%) Query 50 LAG-DVLLWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALAT 108 LAG + LL GPP ++ A+ G S + R W +G P+ ++ DVDAL Sbjct 23 LAGHERLLLGGPPALSMREMAERAGTSLELARRFWRSMGFADVDPEETRFTENDVDALRN 82 Query 109 WVALKALVGEDG---------------AFGLLRVLGTAMARLA--EAESTMIRAGSPNIQ 151 VA +DG ++R M RL + E+ + G Q Sbjct 83 -VADLIDDTDDGLPSPAAPGGGLAASSVLEMMRAQSFTMDRLVLWQLETLVTDIG----Q 137 Query 152 MTHTHDELATARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGVI--------GDTSA 203 H D A A E V + A + V R HLA+ + + I G Sbjct 138 RLHLDDTSARLVALDHVDEMVESLSAQLGYVWRRHLAALISRTDAEIARRGREDAGPDLY 197 Query 204 SVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVS 263 +T +GF D+ SFT Q + +L +L +F++ DVV + G R+VK IGDAVM+++ Sbjct 198 PLTRSLGFVDIVSFTQRAQTMGRKELSAMLEDFESTARDVVTSRGARVVKTIGDAVMYIA 257 Query 264 SSPERLVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPG 323 LVD A + VRA L G V++ +GD FG PVNLA+RLV A PG Sbjct 258 DDLLVAAEVVTALVDELQAGPDMILVRASLVQGRVVSRSGDVFGPPVNLASRLVGTAEPG 317 Query 324 QI 325 I Sbjct 318 GI 319 >gi|269124425|ref|YP_003297795.1| adenylate/guanylate cyclase [Thermomonospora curvata DSM 43183] gi|268309383|gb|ACY95757.1| adenylate/guanylate cyclase [Thermomonospora curvata DSM 43183] Length=334 Score = 103 bits (258), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 95/290 (33%), Positives = 127/290 (44%), Gaps = 8/290 (2%) Query 56 LWSGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVAL--K 113 L GP YT A G+ AD R W LG D + DV AL L Sbjct 15 LLGGPARYTRAQVEKLSGVPADYGLRIWRALGFPTPPEDEAAFTDEDVAALQEIRELLDT 74 Query 114 ALVGEDGAFGLLRVLGTAMARLAE-AESTMIRAGSPNIQMTHTHDELATARAYRAAAEFV 172 LV E+ L R +G M RLA +R I E A A E Sbjct 75 ELVDEEMVLHLARAVGQTMGRLAGWLGGVWLRRLGQEIPDDQPVTEELVFTALAATEELR 134 Query 173 PRIGALIDTVHRHHLASARTYFEGVIGDTSASVTCGI-----GFADLSSFTALTQALTPA 227 PR L+ R LA++ + +A G+ GFAD+ SFT L++ + Sbjct 135 PRFERLLLHGWRRQLAASALHSLTTTAAATADPASGVALMAAGFADVVSFTRLSRRMDER 194 Query 228 QLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL 287 +L + + F+A ++ GGRLVK +GD V +V++ A+ L G Sbjct 195 ELAEFVERFEATAAGIIADLGGRLVKTLGDEVFFVAADAAVAAEIALSLAGRHGVDPGFP 254 Query 288 QVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQILAAAQLRDMLPD 337 +VRAGLAYG V+ GD+FG PVNLAARL + A PG +L +L L D Sbjct 255 RVRAGLAYGEVILRLGDFFGTPVNLAARLTSIAYPGAVLVDGELAAALAD 304 >gi|343924407|ref|ZP_08763956.1| adenylate cyclase [Gordonia alkanivorans NBRC 16433] gi|343765551|dbj|GAA10882.1| adenylate cyclase [Gordonia alkanivorans NBRC 16433] Length=312 Score = 103 bits (258), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 80/270 (30%), Positives = 131/270 (49%), Gaps = 17/270 (6%) Query 58 SGPPIYTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVG 117 + P YT ELG+ +D +AW+ G + +++DV AL + A A + Sbjct 13 ANEPRYTRDELIAELGIESDFAEKAWNAFGFVRRSTNDKVATESDVAALRMFAASSAAMP 72 Query 118 EDGAFGLLRVLGTAMARLAEAESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGA 177 E + R +G M+RLA+ E+ +R + + + + ++++ A +G Sbjct 73 ESTQIAMARAIGQTMSRLADWEADQLREIADDPDIPWSLEQMSAA------------LGQ 120 Query 178 LIDTVHRHHLASARTYFEGVIGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFD 237 + + R H+A A D + +GFAD+ +T+L++ + A L+ LL F+ Sbjct 121 VQQLIWRRHMALALERHADHSADEQFDLI--VGFADIVGYTSLSRRIDLADLEALLGSFE 178 Query 238 AAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL-QVRAGLAYG 296 DVV GGR+VK +GDAVM+ AA+ + H + + +R GLA G Sbjct 179 DDTFDVVVDHGGRVVKTLGDAVMFTFEDAHAAAAAAIRI--HELSENDHVPPLRVGLARG 236 Query 297 TVLALNGDYFGNPVNLAARLVAAAAPGQIL 326 VL GD FG PVN+A+RL ++A PG L Sbjct 237 PVLTRLGDVFGEPVNIASRLASSARPGTTL 266 >gi|84498094|ref|ZP_00996891.1| adenylyl cyclase class-3/4/guanylyl cyclase [Janibacter sp. HTCC2649] gi|84381594|gb|EAP97477.1| adenylyl cyclase class-3/4/guanylyl cyclase [Janibacter sp. HTCC2649] Length=364 Score = 103 bits (258), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 83/270 (31%), Positives = 126/270 (47%), Gaps = 14/270 (5%) Query 71 ELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATW--VALKALVGEDGAFGLLRVL 128 E +S + W LG + + ++AD+DAL +A + ED A + R Sbjct 43 EASVSVQSARKFWHALGFQIVDDEDLMFTEADLDALRRVADLARDNDLDEDLALAMARAF 102 Query 129 GTAMARLAEAESTMI-RAGSPNIQMTHTHDELATARAYRAAAE--------FVPRIGALI 179 RLA ++ ++ +P Q ++ A + R AE V ++ L+ Sbjct 103 ARTSDRLAVWQTQLVAEYLTPPEQEAEIGEKDARSVPDRGVAEAAATALVDIVDQLEPLM 162 Query 180 DTVHRHHLASARTYFEGVIGDTSASVTCG---IGFADLSSFTALTQALTPAQLQDLLTEF 236 V R HL SA T DT + +GFADL +FT+L + +T QL L+ F Sbjct 163 VYVWRRHLTSAITRMLADARDTDHDPSAPLRVVGFADLVNFTSLVRRMTERQLGTLVQRF 222 Query 237 DAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAELQVRAGLAYG 296 + +DVV GGR++K +GD V++V + +DLVD G VR G+AYG Sbjct 223 EELASDVVTTHGGRVIKTVGDEVLFVHVDADAAAAIGLDLVDAMGEDPLLPDVRVGMAYG 282 Query 297 TVLALNGDYFGNPVNLAARLVAAAAPGQIL 326 V++ GD FG VN A+RL A PG++ Sbjct 283 KVISRLGDVFGTTVNRASRLTAVTPPGRVF 312 >gi|283458553|ref|YP_003363183.1| adenylate cyclase, family 3 [Rothia mucilaginosa DY-18] gi|283134598|dbj|BAI65363.1| adenylate cyclase, family 3 [Rothia mucilaginosa DY-18] Length=424 Score = 102 bits (255), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 88/308 (29%), Positives = 140/308 (46%), Gaps = 28/308 (9%) Query 63 YTLATAADELGLSADDVARAWSLLGLTVAGPDVPTLSQADVDALATWVALKALVGEDGAF 122 YT AA+ GL + R W +G P ++ DV LA L A DG Sbjct 105 YTPVEAAECAGLPLETAQRIWHNVGFPTIPNHSPYFTETDVQMLADLQKLDA----DGDI 160 Query 123 GLLRVLGTAMARLAEAESTM---IRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALI 179 + V A + T+ I A NI +T + L+ A R + PR ++ Sbjct 161 RMEYVASLVRAEGQLTDRTVAWQIEALVHNIMVT---ENLSDNDARRKLLKDFPRYLEVL 217 Query 180 DTVHRHHLASARTYFEGVI--GDTSASVTC----------GIGFADLSSFTALTQALTPA 227 + + + A R + G++ G +VT G+GF DL S+T+L + L A Sbjct 218 ERLALY--AYRRQMYAGILRLGLRENNVTTSGLSRLPLVRGVGFVDLVSYTSLVRNLDAA 275 Query 228 QLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPERLVRAAVDLVDHPGARAAEL 287 L L+ F+ + DV+ GGR++K +GD V +++ +P+ + ++ L + GA Sbjct 276 ALSQLINHFEQSCLDVIAPLGGRIIKTLGDEVFFLTETPDTIAEISLQLSEKIGADPQLP 335 Query 288 QVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAPGQIL----AAAQLRDMLPDWPALAH 343 + R +G VLA GD +G+ VNLAARLV+ A PG +L A LR + + + Sbjct 336 EARVAFIWGEVLANRGDVYGSSVNLAARLVSLAEPGTVLTDNETANTLRQVGNRYTLTSQ 395 Query 344 GPLTLKGF 351 G ++ F Sbjct 396 GTRNVRSF 403 >gi|326383576|ref|ZP_08205262.1| adenylyl cyclase class-3/4/guanylyl cyclase [Gordonia neofelifaecis NRRL B-59395] gi|326197660|gb|EGD54848.1| adenylyl cyclase class-3/4/guanylyl cyclase [Gordonia neofelifaecis NRRL B-59395] Length=299 Score = 102 bits (255), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 90/287 (32%), Positives = 133/287 (47%), Gaps = 28/287 (9%) Query 81 RAWSLLGLTV-AGPDVPTLSQADVDALATWVALKALVGEDGAFGLLRVLGTAMARLAE-- 137 R W+ G A D S+AD+ AL+ + + R +G A ARLA+ Sbjct 26 RFWNAFGFAQGADGDGQRFSKADLAALSVFAGNDQAMDSTAQLAAARAIGQATARLAQWQ 85 Query 138 AESTMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGALIDTVHRHHLASARTYFEGV 197 AE A PN++ T + V + + D V R HLA+ T Sbjct 86 AEEITRLAADPNVEAT--------------TEQMVEALARVQDMVWRRHLAAGLTD---- 127 Query 198 IGDTSASVTCGIGFADLSSFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGD 257 G S +GFAD+ +T++++ L +L+ LL F++A ++ GG+++K IGD Sbjct 128 AGRDSEHTEVVVGFADIVGYTSMSRRLGMTELESLLETFESAAHAIITGHGGQIIKTIGD 187 Query 258 AVMWVSSSPERLVRAAVDLVDHPGARAAEL-QVRAGLAYGTVLALNGDYFGNPVNLAARL 316 AVM+ S P A+DL H EL +R G+A G VL GD FG PVN+AARL Sbjct 188 AVMFTVSDPTAAAEIAIDL--HGLTADGELPSLRIGMARGDVLMRMGDAFGEPVNIAARL 245 Query 317 VAAAAPGQILAAAQLRDMLPDWPALAHGP---LTLKGFDAPVMAFEL 360 ++A L L L D L P L+++G+ + AF+L Sbjct 246 ASSARSTTTLIDDDLASALRDLEPLHVSPISSLSVRGY-RKLRAFKL 291 Lambda K H 0.320 0.134 0.394 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 728181445350 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40