BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2225 Length=281 Score E Sequences producing significant alignments: (Bits) Value gi|339295141|gb|AEJ47252.1| 3-methyl-2-oxobutanoate hydroxymethy... 568 3e-160 gi|15609362|ref|NP_216741.1| 3-methyl-2-oxobutanoate hydroxymeth... 568 3e-160 gi|289447855|ref|ZP_06437599.1| 3-methyl-2-oxobutanoate hydroxym... 566 8e-160 gi|326903839|gb|EGE50772.1| 3-methyl-2-oxobutanoate hydroxymethy... 566 1e-159 gi|340627230|ref|YP_004745682.1| putative 3-methyl-2-oxobutanoat... 566 2e-159 gi|183983289|ref|YP_001851580.1| 3-methyl-2-oxobutanoate hydroxy... 513 1e-143 gi|118617024|ref|YP_905356.1| 3-methyl-2-oxobutanoate hydroxymet... 510 7e-143 gi|240168300|ref|ZP_04746959.1| 3-methyl-2-oxobutanoate hydroxym... 508 3e-142 gi|254819831|ref|ZP_05224832.1| 3-methyl-2-oxobutanoate hydroxym... 501 5e-140 gi|342857239|ref|ZP_08713895.1| 3-methyl-2-oxobutanoate hydroxym... 497 6e-139 gi|41408068|ref|NP_960904.1| 3-methyl-2-oxobutanoate hydroxymeth... 491 6e-137 gi|296166106|ref|ZP_06848551.1| 3-methyl-2-oxobutanoate hydroxym... 488 3e-136 gi|108800298|ref|YP_640495.1| 3-methyl-2-oxobutanoate hydroxymet... 481 5e-134 gi|118465863|ref|YP_881443.1| 3-methyl-2-oxobutanoate hydroxymet... 478 6e-133 gi|145223490|ref|YP_001134168.1| 3-methyl-2-oxobutanoate hydroxy... 477 9e-133 gi|120404571|ref|YP_954400.1| 3-methyl-2-oxobutanoate hydroxymet... 468 5e-130 gi|254774929|ref|ZP_05216445.1| 3-methyl-2-oxobutanoate hydroxym... 455 3e-126 gi|15827863|ref|NP_302126.1| 3-methyl-2-oxobutanoate hydroxymeth... 455 3e-126 gi|169629004|ref|YP_001702653.1| 3-methyl-2-oxobutanoate hydroxy... 447 8e-124 gi|111018182|ref|YP_701154.1| 3-methyl-2-oxobutanoate hydroxymet... 439 2e-121 gi|333990315|ref|YP_004522929.1| 3-methyl-2-oxobutanoate hydroxy... 434 7e-120 gi|54023618|ref|YP_117860.1| 3-methyl-2-oxobutanoate hydroxymeth... 433 1e-119 gi|118467777|ref|YP_888575.1| 3-methyl-2-oxobutanoate hydroxymet... 433 1e-119 gi|226360309|ref|YP_002778087.1| 3-methyl-2-oxobutanoate hydroxy... 427 8e-118 gi|226307138|ref|YP_002767098.1| 3-methyl-2-oxobutanoate hydroxy... 427 1e-117 gi|326382479|ref|ZP_08204170.1| 3-methyl-2-oxobutanoate hydroxym... 424 8e-117 gi|312140228|ref|YP_004007564.1| 3-methyl-2-oxobutanoate hydroxy... 424 1e-116 gi|325677025|ref|ZP_08156696.1| 3-methyl-2-oxobutanoate hydroxym... 423 2e-116 gi|343924138|ref|ZP_08763701.1| 3-methyl-2-oxobutanoate hydroxym... 422 3e-116 gi|262202981|ref|YP_003274189.1| 3-methyl-2-oxobutanoatehydroxym... 410 9e-113 gi|333918922|ref|YP_004492503.1| 3-methyl-2-oxobutanoate hydroxy... 401 6e-110 gi|317507911|ref|ZP_07965607.1| ketopantoate hydroxymethyltransf... 387 1e-105 gi|296392959|ref|YP_003657843.1| 3-methyl-2-oxobutanoatehydroxym... 375 4e-102 gi|319950944|ref|ZP_08024817.1| 3-methyl-2-oxobutanoate hydroxym... 374 1e-101 gi|302524476|ref|ZP_07276818.1| 3-methyl-2-oxobutanoate hydroxym... 369 3e-100 gi|238060380|ref|ZP_04605089.1| 3-methyl-2-oxobutanoate hydroxym... 363 2e-98 gi|134098188|ref|YP_001103849.1| 3-methyl-2-oxobutanoate hydroxy... 362 5e-98 gi|302869088|ref|YP_003837725.1| 3-methyl-2-oxobutanoate hydroxy... 358 6e-97 gi|330469436|ref|YP_004407179.1| 3-methyl-2-oxobutanoate hydroxy... 357 2e-96 gi|158564089|sp|Q0RFD5.2|PANB_FRAAA RecName: Full=3-methyl-2-oxo... 355 4e-96 gi|257054800|ref|YP_003132632.1| ketopantoate hydroxymethyltrans... 354 7e-96 gi|300783135|ref|YP_003763426.1| 3-methyl-2-oxobutanoate hydroxy... 352 3e-95 gi|312195606|ref|YP_004015667.1| 3-methyl-2-oxobutanoate hydroxy... 350 1e-94 gi|324998644|ref|ZP_08119756.1| 3-methyl-2-oxobutanoate hydroxym... 350 1e-94 gi|284991821|ref|YP_003410375.1| 3-methyl-2-oxobutanoatehydroxym... 350 2e-94 gi|158313598|ref|YP_001506106.1| 3-methyl-2-oxobutanoate hydroxy... 349 3e-94 gi|84496749|ref|ZP_00995603.1| 3-methyl-2-oxobutanoate hydroxyme... 347 2e-93 gi|152967242|ref|YP_001363026.1| 3-methyl-2-oxobutanoate hydroxy... 345 5e-93 gi|311742910|ref|ZP_07716718.1| 3-methyl-2-oxobutanoate hydroxym... 343 1e-92 gi|331697750|ref|YP_004333989.1| 3-methyl-2-oxobutanoate hydroxy... 342 3e-92 >gi|339295141|gb|AEJ47252.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium tuberculosis CCDC5079] gi|339298761|gb|AEJ50871.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium tuberculosis CCDC5180] Length=282 Score = 568 bits (1465), Expect = 3e-160, Method: Compositional matrix adjust. Identities = 281/281 (100%), Positives = 281/281 (100%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 2 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 61 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR Sbjct 62 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 121 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ Sbjct 122 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 181 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS Sbjct 182 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 241 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF Sbjct 242 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 282 >gi|15609362|ref|NP_216741.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium tuberculosis H37Rv] gi|15841718|ref|NP_336755.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium tuberculosis CDC1551] gi|31793405|ref|NP_855898.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium bovis AF2122/97] 78 more sequence titles Length=281 Score = 568 bits (1464), Expect = 3e-160, Method: Compositional matrix adjust. Identities = 281/281 (100%), Positives = 281/281 (100%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR Sbjct 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ Sbjct 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS Sbjct 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF Sbjct 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 >gi|289447855|ref|ZP_06437599.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase panB [Mycobacterium tuberculosis CPHL_A] gi|289420813|gb|EFD18014.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase panB [Mycobacterium tuberculosis CPHL_A] Length=281 Score = 566 bits (1460), Expect = 8e-160, Method: Compositional matrix adjust. Identities = 280/281 (99%), Positives = 281/281 (100%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR Sbjct 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPV+AHIGFTPQSVNTLGGFRVQGRGDAAEQ Sbjct 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVIAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS Sbjct 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF Sbjct 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 >gi|326903839|gb|EGE50772.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase panB [Mycobacterium tuberculosis W-148] Length=281 Score = 566 bits (1459), Expect = 1e-159, Method: Compositional matrix adjust. Identities = 280/281 (99%), Positives = 280/281 (99%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR Sbjct 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ Sbjct 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 TIADAIAVAEAGAFAVVMEMVPAELATQIT KLTIPTVGIGAGPNCDGQVLVWQDMAGFS Sbjct 181 TIADAIAVAEAGAFAVVMEMVPAELATQITAKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF Sbjct 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 >gi|340627230|ref|YP_004745682.1| putative 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium canettii CIPT 140010059] gi|340005420|emb|CCC44580.1| putative 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium canettii CIPT 140010059] Length=281 Score = 566 bits (1458), Expect = 2e-159, Method: Compositional matrix adjust. Identities = 280/281 (99%), Positives = 280/281 (99%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADG KWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGQKWAMLTAYDYSTARIFDEAGIPVLLV 60 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR Sbjct 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ Sbjct 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS Sbjct 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF Sbjct 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 >gi|183983289|ref|YP_001851580.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium marinum M] gi|254778199|sp|B2HHM7.1|PANB_MYCMM RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|183176615|gb|ACC41725.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium marinum M] Length=297 Score = 513 bits (1322), Expect = 1e-143, Method: Compositional matrix adjust. Identities = 250/289 (87%), Positives = 267/289 (93%), Gaps = 9/289 (3%) Query 2 SEQTIYGANTP---------GGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDE 52 SEQ +YGA++P S PRTK+RTHHLQ+WKA+GHKWAMLT YDYSTAR FD+ Sbjct 9 SEQNVYGASSPVPAGESSPSAASAPRTKVRTHHLQKWKAEGHKWAMLTVYDYSTARAFDD 68 Query 53 AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPT 112 AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYE+GP+ Sbjct 69 AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYESGPS 128 Query 113 AALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQ 172 AALAAATRF+K+ GAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQ Sbjct 129 AALAAATRFMKEAGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQ 188 Query 173 GRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLV 232 GRGDAAEQTIADAIAVAEAGAF+VVMEMVPAELATQITGKLTIPT+GIGAGP+CDGQVLV Sbjct 189 GRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQVLV 248 Query 233 WQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 WQDMAG S K RFVKRYADVGGELRRAA+QYAQ+VAGGVFPA+EH F Sbjct 249 WQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHCF 297 >gi|118617024|ref|YP_905356.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium ulcerans Agy99] gi|158512382|sp|A0PNG6.1|PANB_MYCUA RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|118569134|gb|ABL03885.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium ulcerans Agy99] Length=297 Score = 510 bits (1314), Expect = 7e-143, Method: Compositional matrix adjust. Identities = 250/289 (87%), Positives = 265/289 (92%), Gaps = 9/289 (3%) Query 2 SEQTIYGANTP---------GGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDE 52 SEQ +YGA P S PRTK+RTHHLQ+WKA+GHKWAMLT YDYSTAR FD+ Sbjct 9 SEQNVYGACPPVPAGESSPSAASAPRTKVRTHHLQKWKAEGHKWAMLTVYDYSTARAFDD 68 Query 53 AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPT 112 AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYE+GP+ Sbjct 69 AGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYESGPS 128 Query 113 AALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQ 172 AALAAATRF+K+ GAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQ Sbjct 129 AALAAATRFMKEAGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQ 188 Query 173 GRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLV 232 GRGDAAEQTIADAIAVAEAGAF+VVMEMVPAELATQITGKLTIPT+GIGAGP+CDGQVLV Sbjct 189 GRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPSCDGQVLV 248 Query 233 WQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 WQDMAG S K RFVKRYADVGGELRRAA+QYAQ+VAGGVFPA+EH F Sbjct 249 WQDMAGLSSGKAPRFVKRYADVGGELRRAAVQYAQDVAGGVFPAEEHCF 297 >gi|240168300|ref|ZP_04746959.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium kansasii ATCC 12478] Length=284 Score = 508 bits (1309), Expect = 3e-142, Method: Compositional matrix adjust. Identities = 256/284 (91%), Positives = 269/284 (95%), Gaps = 3/284 (1%) Query 1 MSEQTIYGA--NTPGG-SGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPV 57 MSEQ IYGA +TP + PRTKIRTHHLQ+WKA+GHKWAMLTAYDYSTAR+FD+AGIPV Sbjct 1 MSEQNIYGAGPSTPADPTAPRTKIRTHHLQKWKAEGHKWAMLTAYDYSTARVFDDAGIPV 60 Query 58 LLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAA 117 LL+GDSAANVVYGYDTTVPIS+DELIPLVRGV RGAPHALVVADLPFGSYEAGPTAALAA Sbjct 61 LLIGDSAANVVYGYDTTVPISVDELIPLVRGVARGAPHALVVADLPFGSYEAGPTAALAA 120 Query 118 ATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDA 177 ATRF+K+GGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDA Sbjct 121 ATRFMKEGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDA 180 Query 178 AEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMA 237 AEQT+ADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMA Sbjct 181 AEQTVADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMA 240 Query 238 GFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 G SG K ARFVKRYAD+ GELRRAA QYA EVAGGVFPA+EH F Sbjct 241 GLSGGKAARFVKRYADIAGELRRAARQYADEVAGGVFPAEEHCF 284 >gi|254819831|ref|ZP_05224832.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium intracellulare ATCC 13950] Length=281 Score = 501 bits (1290), Expect = 5e-140, Method: Compositional matrix adjust. Identities = 250/281 (89%), Positives = 266/281 (95%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSE +YGAN+P + P TKIRTHHLQ+WKA+GHKWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 1 MSEHNVYGANSPAPAQPLTKIRTHHLQKWKAEGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVP+S+DELIPLVRGVVRGA A+VVADLPFGSYEAGP AALAAATR Sbjct 61 GDSAANVVYGYDTTVPVSVDELIPLVRGVVRGAQQAMVVADLPFGSYEAGPAAALAAATR 120 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 F+K+GGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRGDAAEQ Sbjct 121 FMKEGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGDAAEQ 180 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 T+ADAIAVAEAGAF+VVMEMVPAELATQITGKLTIPT+GIGAGPNCDGQVLVWQDMAG S Sbjct 181 TVADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDMAGMS 240 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 K ARFVKR+AD+GGELRRAA QYAQEVAGGVFPADEH F Sbjct 241 SGKAARFVKRFADLGGELRRAATQYAQEVAGGVFPADEHCF 281 >gi|342857239|ref|ZP_08713895.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium colombiense CECT 3035] gi|342134572|gb|EGT87738.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium colombiense CECT 3035] Length=282 Score = 497 bits (1280), Expect = 6e-139, Method: Compositional matrix adjust. Identities = 253/282 (90%), Positives = 264/282 (94%), Gaps = 1/282 (0%) Query 1 MSEQTIYGANTPGG-SGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLL 59 MSE +YGAN+P PRTKIRTHHLQ+ KA+GHKWAMLTAYDYSTARIFDEAGIPVLL Sbjct 1 MSEHNVYGANSPAQPEKPRTKIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIPVLL 60 Query 60 VGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAAT 119 VGDSAANVVYGYDTTVP+SIDELIPLVRGVVRGAPHALVVADLPFGSYEAGP AALAAAT Sbjct 61 VGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAAT 120 Query 120 RFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAE 179 RF+K+GGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVN LGGFRVQGRGDAAE Sbjct 121 RFMKEGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAE 180 Query 180 QTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGF 239 QT+ DAIAVAEAGAF+VVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAG Sbjct 181 QTVHDAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGM 240 Query 240 SGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 S K ARFVKR+AD+GGELRRAA QYA EVAGGVFPADEH F Sbjct 241 SSGKAARFVKRFADIGGELRRAATQYAHEVAGGVFPADEHCF 282 >gi|41408068|ref|NP_960904.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium avium subsp. paratuberculosis K-10] gi|61214203|sp|Q73YI6.1|PANB_MYCPA RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|41396423|gb|AAS04287.1| PanB [Mycobacterium avium subsp. paratuberculosis K-10] gi|336461829|gb|EGO40685.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium avium subsp. paratuberculosis S397] Length=285 Score = 491 bits (1263), Expect = 6e-137, Method: Compositional matrix adjust. Identities = 251/285 (89%), Positives = 264/285 (93%), Gaps = 4/285 (1%) Query 1 MSEQTIYGANTPGGSG----PRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIP 56 MSE +YGA P G PRT+IRTHHLQ+ KA+GHKWAMLTAYDYSTARIFDEAGIP Sbjct 1 MSEHNVYGAAQPAQPGQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIP 60 Query 57 VLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALA 116 VLLVGDSAANVVYGYDTTVP+SIDELIPLVRGVVRGAPHALVVADLPFGSYEAGP AALA Sbjct 61 VLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALA 120 Query 117 AATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGD 176 AATRF+K+GGAHAVKLEGGERVAEQIA LTAAGIPVMAHIGFTPQSVN+LGGFRVQGRGD Sbjct 121 AATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGD 180 Query 177 AAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDM 236 AAEQTIADAIAVAEAGAF+VVMEMVPAELATQITGKLTIPT+GIGAGPNCDGQVLVWQDM Sbjct 181 AAEQTIADAIAVAEAGAFSVVMEMVPAELATQITGKLTIPTIGIGAGPNCDGQVLVWQDM 240 Query 237 AGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 AG S K+ARFVKR+AD+GGELRRAA QYA EVA GVFPADEH F Sbjct 241 AGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF 285 >gi|296166106|ref|ZP_06848551.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295898515|gb|EFG78076.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=281 Score = 488 bits (1257), Expect = 3e-136, Method: Compositional matrix adjust. Identities = 247/281 (88%), Positives = 261/281 (93%), Gaps = 0/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQ IYGA + P TKIRTHHLQ+ KA+GHKWAMLTAYDYSTARIFDEAGIPVLLV Sbjct 1 MSEQNIYGAGASEKAQPLTKIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVP+SIDE+IPLVRGVVRGA HALVVADLPFGSYEAGP AALA+ATR Sbjct 61 GDSAANVVYGYDTTVPVSIDEMIPLVRGVVRGARHALVVADLPFGSYEAGPAAALASATR 120 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 F+K+GGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGRGDAAEQ Sbjct 121 FMKEGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGDAAEQ 180 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 T+ADAIAVAEAGAF VVMEMVPA+LATQITGKLTIPTVGIGAGP+CDGQVLVWQDMAG S Sbjct 181 TVADAIAVAEAGAFCVVMEMVPADLATQITGKLTIPTVGIGAGPSCDGQVLVWQDMAGVS 240 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 K ARFVKR+AD+GGELRRAAMQYAQEVA FPADEH F Sbjct 241 SGKAARFVKRFADIGGELRRAAMQYAQEVAEETFPADEHCF 281 >gi|108800298|ref|YP_640495.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium sp. MCS] gi|119869426|ref|YP_939378.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium sp. KMS] gi|126435921|ref|YP_001071612.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium sp. JLS] 6 more sequence titles Length=282 Score = 481 bits (1238), Expect = 5e-134, Method: Compositional matrix adjust. Identities = 237/282 (85%), Positives = 255/282 (91%), Gaps = 1/282 (0%) Query 1 MSEQTIYGANTPGGS-GPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLL 59 MSEQT+YGA + + PR K+RT HLQ+WKA+GHKWAMLTAYD+STAR FD+AGIPVLL Sbjct 1 MSEQTVYGAASDQPTPKPRVKVRTTHLQKWKAEGHKWAMLTAYDFSTARAFDDAGIPVLL 60 Query 60 VGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAAT 119 VGDSAANVVYGYDTTVPI+IDELIPLVRGVVRGAPHALVVADLPFGSYE GP ALA AT Sbjct 61 VGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPHALVVADLPFGSYEEGPRQALATAT 120 Query 120 RFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAE 179 RFLK+ GAHAVKLEGGERVAEQIA L+AAGIPVMAHIGFTPQSVN LGGF+VQGRGDAAE Sbjct 121 RFLKETGAHAVKLEGGERVAEQIATLSAAGIPVMAHIGFTPQSVNGLGGFKVQGRGDAAE 180 Query 180 QTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGF 239 QTI DAIAV EAGAF+VVMEMVPAELATQITGKLTIPTVGIGAGPNCD QVLVWQDMAG Sbjct 181 QTIHDAIAVQEAGAFSVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQDMAGL 240 Query 240 SGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 + +TA+FVKR+ DVG ELRRAA QYA EVA GVFPA+EHSF Sbjct 241 TSGRTAKFVKRFGDVGAELRRAASQYADEVAAGVFPAEEHSF 282 >gi|118465863|ref|YP_881443.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium avium 104] gi|158512436|sp|A0QEV5.1|PANB_MYCA1 RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|118167150|gb|ABK68047.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium avium 104] Length=285 Score = 478 bits (1229), Expect = 6e-133, Method: Compositional matrix adjust. Identities = 248/285 (88%), Positives = 261/285 (92%), Gaps = 4/285 (1%) Query 1 MSEQTIYGANTPGGSGP----RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIP 56 MSE +YGA P RT+IRTHHLQ+ KA+GHKWAMLTAYDYSTARIFDEAGIP Sbjct 1 MSEHNVYGAAQPAQPAQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIP 60 Query 57 VLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALA 116 VLLVGDSAANVVYGYDTTVP+SIDELIPLVRGVVRGAPHALVVADLPFGSYEAGP AALA Sbjct 61 VLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALA 120 Query 117 AATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGD 176 AATRF+K+GGAHAVKLEGGERVAEQIA LTAAGIPVMAHIGFTPQSVN+LGGFRVQGRGD Sbjct 121 AATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGD 180 Query 177 AAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDM 236 AAEQTIADAIAVAEAGAF+VVMEMVPA LATQITGKLTIPT+GIGAGPNCDGQVLVWQDM Sbjct 181 AAEQTIADAIAVAEAGAFSVVMEMVPAGLATQITGKLTIPTIGIGAGPNCDGQVLVWQDM 240 Query 237 AGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 AG S K+ARFVKR+AD+GGELRRAA QYA EVA GVFPADEH F Sbjct 241 AGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF 285 >gi|145223490|ref|YP_001134168.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium gilvum PYR-GCK] gi|315443849|ref|YP_004076728.1| Ketopantoate hydroxymethyltransferase [Mycobacterium sp. Spyr1] gi|145215976|gb|ABP45380.1| ketopantoate hydroxymethyltransferase [Mycobacterium gilvum PYR-GCK] gi|315262152|gb|ADT98893.1| ketopantoate hydroxymethyltransferase [Mycobacterium sp. Spyr1] Length=283 Score = 477 bits (1227), Expect = 9e-133, Method: Compositional matrix adjust. Identities = 234/283 (83%), Positives = 253/283 (90%), Gaps = 2/283 (0%) Query 1 MSEQTIYGA--NTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVL 58 MSEQ++YGA T S PR K+RTHHL +WK++GHKWAMLTAYDYSTA +FDEA IPVL Sbjct 1 MSEQSVYGAGAETAVSSAPRVKVRTHHLHKWKSEGHKWAMLTAYDYSTAAVFDEAQIPVL 60 Query 59 LVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAA 118 LVGDSAANVVYGYDTTVP+++DELIPLVRGVVRGAPHALVVADLPFGSYEAG ALA A Sbjct 61 LVGDSAANVVYGYDTTVPVTLDELIPLVRGVVRGAPHALVVADLPFGSYEAGAQQALATA 120 Query 119 TRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAA 178 TR LK+ GAHAVKLEGGERVAEQIA +TAAGIPVMAHIGFTPQSVN LGGFRVQGRGDAA Sbjct 121 TRMLKETGAHAVKLEGGERVAEQIAAVTAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAA 180 Query 179 EQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAG 238 EQTI DAIAV EAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCD QVLVWQDMAG Sbjct 181 EQTIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQDMAG 240 Query 239 FSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 + +TA+FVKR+ VG ELRRAA +YAQEVA GVFPA+EHS+ Sbjct 241 MTNGRTAKFVKRFGAVGDELRRAATEYAQEVATGVFPAEEHSY 283 >gi|120404571|ref|YP_954400.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium vanbaalenii PYR-1] gi|30173127|sp|Q9L7B2.1|PANB_MYCVP RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|6980036|gb|AAF34708.1|AF223945_1 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium vanbaalenii PYR-1] gi|119957389|gb|ABM14394.1| ketopantoate hydroxymethyltransferase [Mycobacterium vanbaalenii PYR-1] Length=280 Score = 468 bits (1204), Expect = 5e-130, Method: Compositional matrix adjust. Identities = 231/281 (83%), Positives = 249/281 (89%), Gaps = 1/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSEQ +YGA PR K+RTHHL +WKA+GHKWAMLTAYDYSTA +FDEA IPVLLV Sbjct 1 MSEQPVYGAAAEAPK-PRVKVRTHHLHKWKAEGHKWAMLTAYDYSTAAVFDEAEIPVLLV 59 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVP+++DELIPLVRGVVRGAPHALVVADLPFGSYEAGP ALA ATR Sbjct 60 GDSAANVVYGYDTTVPVTLDELIPLVRGVVRGAPHALVVADLPFGSYEAGPQQALATATR 119 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 LK+ GAHAVKLEGGERVA+QIA ++AAGIPVMAHIGFTPQSVN LGGFRVQGRGDAAEQ Sbjct 120 MLKETGAHAVKLEGGERVADQIAAVSAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDAAEQ 179 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 TI DAIAV EAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGP+CD QVLVWQDMAG + Sbjct 180 TIHDAIAVQEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPSCDAQVLVWQDMAGMT 239 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FVKR+ VG ELRRAA YA+EVA G FPADEHS+ Sbjct 240 NGKTAKFVKRFGAVGDELRRAASDYAREVATGAFPADEHSY 280 >gi|254774929|ref|ZP_05216445.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium avium subsp. avium ATCC 25291] Length=253 Score = 455 bits (1171), Expect = 3e-126, Method: Compositional matrix adjust. Identities = 233/252 (93%), Positives = 243/252 (97%), Gaps = 0/252 (0%) Query 30 KADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGV 89 KA+GHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVP+SIDELIPLVRGV Sbjct 2 KAEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPVSIDELIPLVRGV 61 Query 90 VRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAG 149 VRGAPHALVVADLPFGSYEAGP AALAAATRF+K+GGAHAVKLEGGERVAEQIA LTAAG Sbjct 62 VRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAG 121 Query 150 IPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQI 209 IPVMAHIGFTPQSVN+LGGFRVQGRGDAAEQTIADAIAVAEAGAF+VVMEMVPAELATQI Sbjct 122 IPVMAHIGFTPQSVNSLGGFRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAELATQI 181 Query 210 TGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEV 269 TGKLTIPT+GIGAGPNCDGQVLVWQDMAG S K+ARFVKR+AD+GGELRRAA QYA EV Sbjct 182 TGKLTIPTIGIGAGPNCDGQVLVWQDMAGMSSGKSARFVKRFADIGGELRRAATQYAHEV 241 Query 270 AGGVFPADEHSF 281 A GVFPADEH F Sbjct 242 AAGVFPADEHCF 253 >gi|15827863|ref|NP_302126.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium leprae TN] gi|221230340|ref|YP_002503756.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium leprae Br4923] gi|18202760|sp|Q9CBT0.1|PANB_MYCLE RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|13093415|emb|CAC30586.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium leprae] gi|219933447|emb|CAR71730.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium leprae Br4923] Length=286 Score = 455 bits (1171), Expect = 3e-126, Method: Compositional matrix adjust. Identities = 237/287 (83%), Positives = 256/287 (90%), Gaps = 7/287 (2%) Query 1 MSEQTI--YGANTPGGSG----PRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAG 54 MSEQ + YGA+ P S RTKIRT HLQ+ KA+GHKWAMLTAYDYSTAR+FDEAG Sbjct 1 MSEQNVNVYGAD-PSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAG 59 Query 55 IPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAA 114 IPVLLVGDSAANVVYGYDTTVP+S DEL+PLVRGVVRGA HALVVADLPFGSYE GPTAA Sbjct 60 IPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAA 119 Query 115 LAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGR 174 LA ATRF+K+GGAHAVKLEGG+RVAEQIACLTAAGIPVMAHIGFTPQSVN+LGGFRVQGR Sbjct 120 LAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGR 179 Query 175 GDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQ 234 G AEQT+ADA+AVAEAGAF+VVMEMVP ELATQITGKLTIPT+GIGAG NCD QVLVWQ Sbjct 180 GGDAEQTVADAVAVAEAGAFSVVMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQ 239 Query 235 DMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 DMAG S K ARFVK+YAD+ GELRRAAMQYA+EVA VFPA+EH F Sbjct 240 DMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF 286 >gi|169629004|ref|YP_001702653.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium abscessus ATCC 19977] gi|169240971|emb|CAM61999.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium abscessus] Length=292 Score = 447 bits (1150), Expect = 8e-124, Method: Compositional matrix adjust. Identities = 223/292 (77%), Positives = 245/292 (84%), Gaps = 11/292 (3%) Query 1 MSEQTIYGANTPGGSGPRTK-----------IRTHHLQRWKADGHKWAMLTAYDYSTARI 49 MSE +YGA + + PRT+ R HHLQ+WKA+GHKW+MLTAYDYSTAR+ Sbjct 1 MSESALYGAASEKSTEPRTQPDALRAKRSSQTRVHHLQKWKAEGHKWSMLTAYDYSTARV 60 Query 50 FDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEA 109 F++AGIPVLLVGDSAANVVYGYDTTVPI+IDELIPLVRGVVRGAP ALVVADLPFGSYE Sbjct 61 FNDAGIPVLLVGDSAANVVYGYDTTVPITIDELIPLVRGVVRGAPEALVVADLPFGSYEG 120 Query 110 GPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGF 169 G ALA+ATRF+K+ GAHAVKLEGGERVAEQIA LTAAGIPV+AHIGFTPQSVN LGG+ Sbjct 121 GAAQALASATRFMKEAGAHAVKLEGGERVAEQIATLTAAGIPVVAHIGFTPQSVNGLGGY 180 Query 170 RVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQ 229 RVQGR DAA Q I DAIAV EAGA AVVMEMVPAELATQITGKLTIPTVGIGAG CD Q Sbjct 181 RVQGRDDAAAQLIHDAIAVQEAGAIAVVMEMVPAELATQITGKLTIPTVGIGAGRECDAQ 240 Query 230 VLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 VLVWQDMAG + KTA+FVK++ VG ELR+AA QYA EVA GVFPA EHS+ Sbjct 241 VLVWQDMAGMTSGKTAKFVKQFGQVGAELRKAAEQYADEVARGVFPAPEHSY 292 >gi|111018182|ref|YP_701154.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus jostii RHA1] gi|122956056|sp|Q0SHJ0.1|PANB_RHOSR RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|110817712|gb|ABG92996.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus jostii RHA1] Length=289 Score = 439 bits (1130), Expect = 2e-121, Method: Compositional matrix adjust. Identities = 214/279 (77%), Positives = 242/279 (87%), Gaps = 1/279 (0%) Query 3 EQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGD 62 E +YG + P P+ K RTHHLQ KA+G +WAMLTAYDYS+ARIF+EAGIPVLLVGD Sbjct 12 EDRLYG-SAPSHDVPKRKTRTHHLQAMKAEGERWAMLTAYDYSSARIFEEAGIPVLLVGD 70 Query 63 SAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFL 122 SAANVVYGY+TTVP++IDEL+PLVRGVVRGAPHALVVADLPFGSYE+ P ALA+ATRF+ Sbjct 71 SAANVVYGYETTVPVTIDELLPLVRGVVRGAPHALVVADLPFGSYESSPEQALASATRFM 130 Query 123 KDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTI 182 K+G AHAVKLEGGERVA QIA +TAAGIPVMAH+GFTPQSVN+LGGFRVQGRGDAAEQ + Sbjct 131 KEGLAHAVKLEGGERVAPQIAAITAAGIPVMAHVGFTPQSVNSLGGFRVQGRGDAAEQLV 190 Query 183 ADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGA 242 ADAIAV EAGAF+VVMEMVPAE+A Q+T KLTIPTVGIGAG CD QVLVWQDMAG++ Sbjct 191 ADAIAVQEAGAFSVVMEMVPAEIAGQVTRKLTIPTVGIGAGVECDAQVLVWQDMAGYTSG 250 Query 243 KTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FVKR+ +VG ELR AA YA EV G FPA+EHSF Sbjct 251 KTAKFVKRFGNVGDELRSAAAAYATEVRAGTFPAEEHSF 289 >gi|333990315|ref|YP_004522929.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium sp. JDM601] gi|333486283|gb|AEF35675.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Mycobacterium sp. JDM601] Length=244 Score = 434 bits (1116), Expect = 7e-120, Method: Compositional matrix adjust. Identities = 216/244 (89%), Positives = 226/244 (93%), Gaps = 0/244 (0%) Query 38 MLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHAL 97 MLTAYDYSTARIFD+AGIPVLLVGDSAANVVYGYD+TVPISIDELIPLVR VVRGAPHAL Sbjct 1 MLTAYDYSTARIFDDAGIPVLLVGDSAANVVYGYDSTVPISIDELIPLVRAVVRGAPHAL 60 Query 98 VVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIG 157 VVADLPFGSYE GP AALA ATRF+K+GGAHAVKLEGGERVAEQIA L+AAGIPVMAHIG Sbjct 61 VVADLPFGSYEGGPAAALATATRFMKEGGAHAVKLEGGERVAEQIATLSAAGIPVMAHIG 120 Query 158 FTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPT 217 FTPQSVNTLGGFRVQGRGDAAEQTI DAIAVAEAGAFAVVMEMVPAELATQITGKLTIPT Sbjct 121 FTPQSVNTLGGFRVQGRGDAAEQTIHDAIAVAEAGAFAVVMEMVPAELATQITGKLTIPT 180 Query 218 VGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPAD 277 VGIGAGPNCD QVLVWQDMAG + KTARFVKR+ DVG EL RAA +YA EV+ G FPA+ Sbjct 181 VGIGAGPNCDAQVLVWQDMAGMTTGKTARFVKRFGDVGAELHRAATRYADEVSAGTFPAE 240 Query 278 EHSF 281 EH F Sbjct 241 EHCF 244 >gi|54023618|ref|YP_117860.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Nocardia farcinica IFM 10152] gi|61213982|sp|Q5YZ95.1|PANB_NOCFA RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|54015126|dbj|BAD56496.1| putative 3-methyl-2-oxobutanoate hydroxymethyltransferase [Nocardia farcinica IFM 10152] Length=283 Score = 433 bits (1114), Expect = 1e-119, Method: Compositional matrix adjust. Identities = 219/280 (79%), Positives = 241/280 (87%), Gaps = 2/280 (0%) Query 2 SEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVG 61 SE YGA P + PR K R HL++ KADG +WAMLTAYDYS+AR+F+EAGIPVLLVG Sbjct 6 SETPAYGAAQP--AQPRRKTRIPHLRQMKADGERWAMLTAYDYSSARLFEEAGIPVLLVG 63 Query 62 DSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRF 121 DSAANVVYGYDTTVPI++DELIPLVRGVVRGAPHALVVADLPFG+YE ALAAATRF Sbjct 64 DSAANVVYGYDTTVPITVDELIPLVRGVVRGAPHALVVADLPFGTYEGSAQQALAAATRF 123 Query 122 LKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQT 181 +K+GGAHAVKLEGGERVAEQIA LTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGD AEQ Sbjct 124 MKEGGAHAVKLEGGERVAEQIALLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDGAEQL 183 Query 182 IADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSG 241 IADAIAV EAGAF+VVMEMVPAELA Q+T KLTIPT+GIGAGP+CD QVLVWQDMAG++ Sbjct 184 IADAIAVQEAGAFSVVMEMVPAELAGQVTRKLTIPTIGIGAGPDCDAQVLVWQDMAGYTS 243 Query 242 AKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FVKR+ D+G +LR AA YA EV G FP EHSF Sbjct 244 GKTAKFVKRFGDIGDQLRAAAAAYAAEVREGTFPGPEHSF 283 >gi|118467777|ref|YP_888575.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium smegmatis str. MC2 155] gi|118169064|gb|ABK69960.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Mycobacterium smegmatis str. MC2 155] Length=287 Score = 433 bits (1113), Expect = 1e-119, Method: Compositional matrix adjust. Identities = 224/287 (79%), Positives = 248/287 (87%), Gaps = 6/287 (2%) Query 1 MSEQTIYGANTPGGS------GPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAG 54 MSEQ IYGA S RTK+RT LQ+WKA+GHKWAMLT YDYS+AR+FD+AG Sbjct 1 MSEQPIYGAANTSQSVVDTKPAQRTKVRTLTLQKWKAEGHKWAMLTCYDYSSARVFDDAG 60 Query 55 IPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAA 114 IPVLLVGDSAANVVYGYDTTVPISIDELIPL R VV+GAPHALV+ DLPFGSYE GP+ A Sbjct 61 IPVLLVGDSAANVVYGYDTTVPISIDELIPLARAVVKGAPHALVIGDLPFGSYEDGPSQA 120 Query 115 LAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGR 174 LA ATRF+K+ G HAVKLEGGERVA+QIA L+ AGIPV+AHIGFTPQSVN LGGFRVQGR Sbjct 121 LATATRFMKEAGVHAVKLEGGERVADQIATLSRAGIPVVAHIGFTPQSVNGLGGFRVQGR 180 Query 175 GDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQ 234 GDAA+QTI DAIAVAEAGA AVV+EMVPAELATQITGKLTIPTVGIGAGPNCD QVLVWQ Sbjct 181 GDAADQTIRDAIAVAEAGAVAVVLEMVPAELATQITGKLTIPTVGIGAGPNCDAQVLVWQ 240 Query 235 DMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 DMAG + KTA+FV+R+ DVGGEL RAA Q+A +VA GVFPA+EHS+ Sbjct 241 DMAGLTSGKTAKFVRRFGDVGGELHRAATQFADDVAAGVFPAEEHSY 287 >gi|226360309|ref|YP_002778087.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus opacus B4] gi|226238794|dbj|BAH49142.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus opacus B4] Length=289 Score = 427 bits (1099), Expect = 8e-118, Method: Compositional matrix adjust. Identities = 211/279 (76%), Positives = 241/279 (87%), Gaps = 1/279 (0%) Query 3 EQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGD 62 E +YG + P P+ K R HHLQ KA+G +W+MLTAYDYS+ARIF+EAGIPVLLVGD Sbjct 12 EDRLYG-SAPSHDVPKRKTRIHHLQAMKAEGERWSMLTAYDYSSARIFEEAGIPVLLVGD 70 Query 63 SAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFL 122 SAANVVYGY+TTVP++IDEL+PLVRGVVRGAPHALVVADLPFGSYE+ P ALA+ATRF+ Sbjct 71 SAANVVYGYETTVPVTIDELLPLVRGVVRGAPHALVVADLPFGSYESSPEQALASATRFM 130 Query 123 KDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTI 182 K+G AHAVKLEGGERVA QIA +TAAGIPVMAH+GFTPQSVN+LGGFRVQGRGDA+EQ + Sbjct 131 KEGLAHAVKLEGGERVAPQIAAITAAGIPVMAHVGFTPQSVNSLGGFRVQGRGDASEQLV 190 Query 183 ADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGA 242 ADAIAV EAGAF+VVMEMVPAE+A Q+T KLTIPTVGIGAG CD QVLVWQDMAG++ Sbjct 191 ADAIAVQEAGAFSVVMEMVPAEIAGQVTRKLTIPTVGIGAGAECDAQVLVWQDMAGYTSG 250 Query 243 KTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FVKR+ +VG ELR AA YA EV G FPA+EHSF Sbjct 251 KTAKFVKRFGNVGDELRTAAAAYAAEVRTGTFPAEEHSF 289 >gi|226307138|ref|YP_002767098.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus erythropolis PR4] gi|229490291|ref|ZP_04384133.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus erythropolis SK121] gi|226186255|dbj|BAH34359.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus erythropolis PR4] gi|229322823|gb|EEN88602.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus erythropolis SK121] Length=283 Score = 427 bits (1097), Expect = 1e-117, Method: Compositional matrix adjust. Identities = 207/283 (74%), Positives = 238/283 (85%), Gaps = 2/283 (0%) Query 1 MSEQTIYGANTPGGS--GPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVL 58 MSE +YG+ S P+ K R HHL K +G +W+MLTAYDYSTARIF++AGIPVL Sbjct 1 MSETPLYGSVPTASSTDAPKRKTRIHHLAEMKQNGERWSMLTAYDYSTARIFEDAGIPVL 60 Query 59 LVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAA 118 LVGDSAANVVYGYDTTVPI++DEL+PLVRGVVRGAPHALVVADLPFG+YE ALA A Sbjct 61 LVGDSAANVVYGYDTTVPITVDELLPLVRGVVRGAPHALVVADLPFGTYEGSAEQALATA 120 Query 119 TRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAA 178 TRF+K+G AHAVKLEGGER+++QIA +T+AGIPVMAH+GFTPQSVN+LGGFRVQGRGDAA Sbjct 121 TRFMKEGLAHAVKLEGGERMSKQIAAITSAGIPVMAHVGFTPQSVNSLGGFRVQGRGDAA 180 Query 179 EQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAG 238 EQ +ADAIAV EAGAF+VVMEMVPAE+A Q++ KLTIPTVGIGAG CD QVLVWQDMAG Sbjct 181 EQLVADAIAVQEAGAFSVVMEMVPAEIAGQVSRKLTIPTVGIGAGSECDAQVLVWQDMAG 240 Query 239 FSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 ++ KTA+FVKR+ +VG ELR AA YA EV G FPA EHSF Sbjct 241 YTSGKTAKFVKRFGNVGDELRSAAAAYASEVRTGAFPAAEHSF 283 >gi|326382479|ref|ZP_08204170.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Gordonia neofelifaecis NRRL B-59395] gi|326198598|gb|EGD55781.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Gordonia neofelifaecis NRRL B-59395] Length=282 Score = 424 bits (1090), Expect = 8e-117, Method: Compositional matrix adjust. Identities = 214/283 (76%), Positives = 235/283 (84%), Gaps = 3/283 (1%) Query 1 MSEQTIYGANTPGGS--GPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVL 58 MS+ ++YG +TP S PR R HHL +WKA+GHKW MLTAYD+STARIFDEA IPVL Sbjct 1 MSDASVYG-STPVTSTQAPRRATRVHHLAQWKAEGHKWPMLTAYDFSTARIFDEAEIPVL 59 Query 59 LVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAA 118 LVGDSAANVVYGYDTT+PI+ DELIPLVR VVRGAPHALVVADLPFG+YEA P AL A Sbjct 60 LVGDSAANVVYGYDTTIPITNDELIPLVRAVVRGAPHALVVADLPFGTYEASPQQALENA 119 Query 119 TRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAA 178 RF K+GGAHAVK+EGGERVA QIA LTAAGIPVM H+GFTPQSVN LGGFRVQGRGDAA Sbjct 120 VRFFKEGGAHAVKIEGGERVAPQIAALTAAGIPVMGHVGFTPQSVNGLGGFRVQGRGDAA 179 Query 179 EQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAG 238 +Q IADAIAV EAGAF+VVMEMVPA++A QIT KLTIPTVGIGAG D QVLVWQDMAG Sbjct 180 DQLIADAIAVQEAGAFSVVMEMVPADIAGQITRKLTIPTVGIGAGNETDAQVLVWQDMAG 239 Query 239 FSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 ++ KTA+FVKRYA VG ELR AA YA EVA FP EHS+ Sbjct 240 YTHGKTAKFVKRYAAVGDELREAARAYATEVATAAFPGPEHSY 282 >gi|312140228|ref|YP_004007564.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase panb [Rhodococcus equi 103S] gi|311889567|emb|CBH48884.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB [Rhodococcus equi 103S] Length=279 Score = 424 bits (1089), Expect = 1e-116, Method: Compositional matrix adjust. Identities = 212/281 (76%), Positives = 236/281 (84%), Gaps = 2/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSE +YG+ P + P+ K R HHLQ KA+G +WA LTAYDYS+AR+F+EAGIPVLLV Sbjct 1 MSENAVYGSAAP--AAPKRKTRIHHLQAMKAEGTRWAELTAYDYSSARLFEEAGIPVLLV 58 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVP++IDE++PLVRGVVRGAPHALVVADLPFGSYEA P AL A R Sbjct 59 GDSAANVVYGYDTTVPVTIDEMLPLVRGVVRGAPHALVVADLPFGSYEASPQQALETAFR 118 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 F+K+G AHAVKLEGGERVA QIA LTAAGIPV AHIGFTPQSVN+LGGFRVQGRGD AEQ Sbjct 119 FMKEGQAHAVKLEGGERVAPQIAALTAAGIPVQAHIGFTPQSVNSLGGFRVQGRGDGAEQ 178 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 +ADAIAV EAGAF+VVMEMVPAELA Q+T KLTIPTVGIGAG CD QVLVWQDMAG++ Sbjct 179 LVADAIAVQEAGAFSVVMEMVPAELAGQVTRKLTIPTVGIGAGNECDAQVLVWQDMAGYT 238 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FVKR+ +VG LR AA YA EV G FPA EHSF Sbjct 239 SGKTAKFVKRFGEVGTALRDAAAAYASEVESGAFPAAEHSF 279 >gi|325677025|ref|ZP_08156696.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus equi ATCC 33707] gi|325552187|gb|EGD21878.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Rhodococcus equi ATCC 33707] Length=279 Score = 423 bits (1087), Expect = 2e-116, Method: Compositional matrix adjust. Identities = 211/281 (76%), Positives = 236/281 (84%), Gaps = 2/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSE +YG+ P + P+ K R HHLQ KA+G +WA LTAYDYS+AR+F+EAGIPVLLV Sbjct 1 MSENAVYGSAAP--AAPKRKTRIHHLQAMKAEGTRWAELTAYDYSSARLFEEAGIPVLLV 58 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVP++IDE++PLVRGVVRGAPHALV+ADLPFGSYEA P AL A R Sbjct 59 GDSAANVVYGYDTTVPVTIDEMLPLVRGVVRGAPHALVIADLPFGSYEASPQQALETAFR 118 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 F+K+G AHAVKLEGGERVA QIA LTAAGIPV AHIGFTPQSVN+LGGFRVQGRGD AEQ Sbjct 119 FMKEGQAHAVKLEGGERVAPQIAALTAAGIPVQAHIGFTPQSVNSLGGFRVQGRGDGAEQ 178 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 +ADAIAV EAGAF+VVMEMVPAELA Q+T KLTIPTVGIGAG CD QVLVWQDMAG++ Sbjct 179 LVADAIAVQEAGAFSVVMEMVPAELAGQVTRKLTIPTVGIGAGNECDAQVLVWQDMAGYT 238 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FVKR+ +VG LR AA YA EV G FPA EHSF Sbjct 239 SGKTAKFVKRFGEVGTALRDAAAAYASEVESGAFPAAEHSF 279 >gi|343924138|ref|ZP_08763701.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Gordonia alkanivorans NBRC 16433] gi|343765943|dbj|GAA10627.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Gordonia alkanivorans NBRC 16433] Length=282 Score = 422 bits (1085), Expect = 3e-116, Method: Compositional matrix adjust. Identities = 210/282 (75%), Positives = 234/282 (83%), Gaps = 1/282 (0%) Query 1 MSEQTIYGANTPGGSGPRTKI-RTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLL 59 MSE ++YGA+T P+ ++ R HHL + K++G +W+MLTAYDYSTA IFD AGIPVLL Sbjct 1 MSESSVYGASTSTTDAPKRRVTRVHHLAQMKSEGERWSMLTAYDYSTACIFDAAGIPVLL 60 Query 60 VGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAAT 119 VGDSAANVV GYDTT+P+S+DE+IPL+R VVRGAPHALVVAD+PFGSYE GP AL A Sbjct 61 VGDSAANVVLGYDTTIPVSVDEMIPLIRAVVRGAPHALVVADMPFGSYEIGPQHALENAI 120 Query 120 RFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAE 179 R K+ GAHAVKLEGGERVA QIA LTAAGIPVMAHIGFTPQSVN LGGFRVQGRGD A+ Sbjct 121 RIFKETGAHAVKLEGGERVAPQIAALTAAGIPVMAHIGFTPQSVNGLGGFRVQGRGDGAD 180 Query 180 QTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGF 239 Q IADAIAV EAGAF+VVMEMVPAELA QIT KLTIPTVGIGAG D QVLVWQDMAG Sbjct 181 QLIADAIAVQEAGAFSVVMEMVPAELAGQITRKLTIPTVGIGAGNETDAQVLVWQDMAGL 240 Query 240 SGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 + KTA+FVKR+ADVG ELR AA QYA EV GVFP EHS+ Sbjct 241 THGKTAKFVKRFADVGSELRSAAEQYADEVRRGVFPGPEHSY 282 >gi|262202981|ref|YP_003274189.1| 3-methyl-2-oxobutanoatehydroxymethyltransferase [Gordonia bronchialis DSM 43247] gi|262086328|gb|ACY22296.1| 3-methyl-2-oxobutanoatehydroxymethyltransferase [Gordonia bronchialis DSM 43247] Length=287 Score = 410 bits (1055), Expect = 9e-113, Method: Compositional matrix adjust. Identities = 211/287 (74%), Positives = 236/287 (83%), Gaps = 6/287 (2%) Query 1 MSEQTIYGANTPGGSG------PRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAG 54 MSE ++YGA P S PR K R HHL + K++G KW+MLTAYDYS+A IFDEA Sbjct 1 MSETSVYGAARPADSATDSPARPRRKTRVHHLAQMKSEGEKWSMLTAYDYSSAAIFDEAQ 60 Query 55 IPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAA 114 IPVLLVGDSAANVV GYDTT+P+S+DE+IPL+R VVRGAPHALVVADLPFG+YEAGP A Sbjct 61 IPVLLVGDSAANVVLGYDTTIPVSLDEMIPLIRAVVRGAPHALVVADLPFGTYEAGPQQA 120 Query 115 LAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGR 174 L +A R K+ GAHAVKLEGGERVA QIA L+AAGIPVMAHIGFTPQSVN LGGFR+QGR Sbjct 121 LESAVRIFKETGAHAVKLEGGERVAAQIAALSAAGIPVMAHIGFTPQSVNGLGGFRIQGR 180 Query 175 GDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQ 234 GDA +Q IADAIAV EAGAF+VVMEMVPA+LA QIT KLTIPT+GIGAG D QVLVWQ Sbjct 181 GDAGDQLIADAIAVQEAGAFSVVMEMVPADLAGQITRKLTIPTIGIGAGNETDAQVLVWQ 240 Query 235 DMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 DMAG + KTA+FVKR+ADVG ELR AA QYA EV GVFPA EHS+ Sbjct 241 DMAGMTHGKTAKFVKRFADVGTELRNAAAQYADEVRRGVFPAPEHSY 287 >gi|333918922|ref|YP_004492503.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Amycolicicoccus subflavus DQS3-9A1] gi|333481143|gb|AEF39703.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Amycolicicoccus subflavus DQS3-9A1] Length=281 Score = 401 bits (1030), Expect = 6e-110, Method: Compositional matrix adjust. Identities = 200/281 (72%), Positives = 226/281 (81%), Gaps = 2/281 (0%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 MSE +YG + G RTK R HHLQ K W MLTAYDY TA+IFD+AGIPVLLV Sbjct 1 MSETPVYG--SAGQQPKRTKTRIHHLQALKEKHEPWPMLTAYDYPTAQIFDDAGIPVLLV 58 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSAANVVYGYDTTVP++IDEL+PLVR VVRGAP+ALVVADLPFGSYE AL + R Sbjct 59 GDSAANVVYGYDTTVPVTIDELLPLVRAVVRGAPNALVVADLPFGSYEVSAEQALETSIR 118 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 FLK+GG HAVKLEGGER+A +I LTAAGIPVMAHIGFTPQSVN+LGGFRVQGRG A+Q Sbjct 119 FLKEGGTHAVKLEGGERMAPKIQALTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGSGADQ 178 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 IADA+AV EAGAF+VVMEMVPAELA+++T KLTIPT+GIGAG CD QVLVWQDMAG + Sbjct 179 LIADALAVQEAGAFSVVMEMVPAELASEVTHKLTIPTIGIGAGNECDAQVLVWQDMAGLN 238 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 KTA+FV+++A VG EL RAA +YA V FPA EHSF Sbjct 239 RGKTAKFVRQFAAVGNELLRAATEYADAVRDRSFPAPEHSF 279 >gi|317507911|ref|ZP_07965607.1| ketopantoate hydroxymethyltransferase [Segniliparus rugosus ATCC BAA-974] gi|316253776|gb|EFV13150.1| ketopantoate hydroxymethyltransferase [Segniliparus rugosus ATCC BAA-974] Length=275 Score = 387 bits (994), Expect = 1e-105, Method: Compositional matrix adjust. Identities = 188/264 (72%), Positives = 218/264 (83%), Gaps = 1/264 (0%) Query 18 RTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPI 77 R ++R HLQ K +G KW+MLTAYDY+TA IFDEA IPVLL+GDSAAN+VYGYDTTVP+ Sbjct 13 RPRVRVKHLQEMKHEGRKWSMLTAYDYTTASIFDEAEIPVLLIGDSAANLVYGYDTTVPV 72 Query 78 SIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGER 137 ++EL+PLVRGVVRGA HALVVADLPFGSYEA P A A RF+K GA AVKLEGGE Sbjct 73 EVEELLPLVRGVVRGAKHALVVADLPFGSYEASPAQAFETAARFMK-AGAGAVKLEGGED 131 Query 138 VAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVV 197 AE IA L+ AG+PVMAHIGFTPQ VN+L GFRVQGRGD AE + DAIAVAEAGAFAVV Sbjct 132 YAEHIALLSRAGVPVMAHIGFTPQRVNSLSGFRVQGRGDDAETLVHDAIAVAEAGAFAVV 191 Query 198 MEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGE 257 MEMVPAE+A QIT KLTIPTVGIGAGP+CD QVLVWQDMAG + +TA+FV+R+A++G + Sbjct 192 MEMVPAEVAAQITAKLTIPTVGIGAGPDCDAQVLVWQDMAGLTTGRTAKFVRRFAEIGKD 251 Query 258 LRRAAMQYAQEVAGGVFPADEHSF 281 L +AA +YA +V G FPA EHS+ Sbjct 252 LGQAAREYANDVQRGAFPAPEHSY 275 >gi|296392959|ref|YP_003657843.1| 3-methyl-2-oxobutanoatehydroxymethyltransferase [Segniliparus rotundus DSM 44985] gi|296180106|gb|ADG97012.1| 3-methyl-2-oxobutanoatehydroxymethyltransferase [Segniliparus rotundus DSM 44985] Length=275 Score = 375 bits (963), Expect = 4e-102, Method: Compositional matrix adjust. Identities = 186/270 (69%), Positives = 212/270 (79%), Gaps = 1/270 (0%) Query 12 PGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGY 71 P + R ++R HL K +G KWAMLTAYDY+TA + D A IPVLLVGDSAANVVYG+ Sbjct 7 PYATQTRPRVRISHLHEMKREGRKWAMLTAYDYTTAALLDAADIPVLLVGDSAANVVYGH 66 Query 72 DTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVK 131 DTTV + DEL+PLVRGV RGA ALVVADLPFGSYEA P A A RF + GAHAVK Sbjct 67 DTTVSVEADELLPLVRGVARGAQRALVVADLPFGSYEASPAQAFETAARFAR-AGAHAVK 125 Query 132 LEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEA 191 LEGGE AE I+ L+ AGIPVMAHIGFTPQ VN+L GFRVQGRGD AE + DAIAVAEA Sbjct 126 LEGGEDYAEHISSLSRAGIPVMAHIGFTPQRVNSLSGFRVQGRGDEAETLVHDAIAVAEA 185 Query 192 GAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRY 251 GAFAVVMEMVPAELA QIT KLTIPTVGIGAGP+CD QVLVWQDMAG + +TA+FV+R+ Sbjct 186 GAFAVVMEMVPAELAAQITAKLTIPTVGIGAGPDCDAQVLVWQDMAGLTAGRTAKFVRRF 245 Query 252 ADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 A++G L AA +YA++V G FPA EHS+ Sbjct 246 AELGAALGEAAREYARDVESGAFPAPEHSY 275 >gi|319950944|ref|ZP_08024817.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Dietzia cinnamea P4] gi|319435391|gb|EFV90638.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Dietzia cinnamea P4] Length=293 Score = 374 bits (960), Expect = 1e-101, Method: Compositional matrix adjust. Identities = 193/285 (68%), Positives = 219/285 (77%), Gaps = 9/285 (3%) Query 6 IYGA-----NTPGGSGPRTKI----RTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIP 56 +YG+ TP G+G + + R HHL KA G W MLTAYD+ +AR+F EAGIP Sbjct 9 VYGSGAAPGQTPTGTGGKEGLTRVTRLHHLAELKAAGEPWPMLTAYDFVSARLFQEAGIP 68 Query 57 VLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALA 116 VLLVGDSAANVVYGYDTTVP++ DE+IPLVR V RGAP ALVVADL FGSYEA PT A+A Sbjct 69 VLLVGDSAANVVYGYDTTVPVTEDEMIPLVRAVTRGAPKALVVADLVFGSYEASPTQAVA 128 Query 117 AATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGD 176 AATR LK+GGA AVKLEGG R+A QI + AGIPVMAH+GFTPQSVN LGGFRVQGRGD Sbjct 129 AATRMLKEGGAQAVKLEGGVRMAPQIRAIVDAGIPVMAHVGFTPQSVNGLGGFRVQGRGD 188 Query 177 AAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDM 236 AAEQ ADA AV EAGAF+VVMEMVPA+LA ++T +L IPTVGIGAG CD QVLVWQDM Sbjct 189 AAEQLRADARAVQEAGAFSVVMEMVPADLAREVTAELEIPTVGIGAGNGCDAQVLVWQDM 248 Query 237 AGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 AG S +TA+FVKRYA++ LR AA +Y EV FP EHSF Sbjct 249 AGHSTGRTAKFVKRYAELADTLREAAREYGTEVRSRAFPGAEHSF 293 >gi|302524476|ref|ZP_07276818.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Streptomyces sp. AA4] gi|302433371|gb|EFL05187.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Streptomyces sp. AA4] Length=295 Score = 369 bits (946), Expect = 3e-100, Method: Compositional matrix adjust. Identities = 181/276 (66%), Positives = 213/276 (78%), Gaps = 1/276 (0%) Query 7 YGANTPGGSGPR-TKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAA 65 YG +GP+ K+R HHL+ K G W MLTAYD TA +FDEAGIPVLLVGDSAA Sbjct 19 YGNGPANAAGPKPRKVRIHHLRELKDRGEPWPMLTAYDMYTAELFDEAGIPVLLVGDSAA 78 Query 66 NVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDG 125 N V+GYDT++P+++DEL+PLVR V R A ALVVADLPFGSY+ P ALA A RF+K+G Sbjct 79 NNVFGYDTSLPVTVDELLPLVRSVTRAAKRALVVADLPFGSYQLSPEQALATAVRFMKEG 138 Query 126 GAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADA 185 AHAVKLEGG R A + LT+AGIPVM HIGFTPQS + LGG+RVQGRG+AAE+ +ADA Sbjct 139 RAHAVKLEGGHRFAAHVEALTSAGIPVMGHIGFTPQSEHNLGGYRVQGRGEAAEKLLADA 198 Query 186 IAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTA 245 +A+ EAGAFAVVMEMVPAE A ++T +L IPTVGIGAGP+CD QVLVWQDMAG K Sbjct 199 LALQEAGAFAVVMEMVPAEAAKRVTHELKIPTVGIGAGPDCDAQVLVWQDMAGLRRGKAP 258 Query 246 RFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 RFVKRYADV G LR AA +A++V G FPA EH+F Sbjct 259 RFVKRYADVAGVLRSAATAFAEDVRRGEFPAPEHAF 294 >gi|238060380|ref|ZP_04605089.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Micromonospora sp. ATCC 39149] gi|237882191|gb|EEP71019.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Micromonospora sp. ATCC 39149] Length=281 Score = 363 bits (931), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 180/267 (68%), Positives = 210/267 (79%), Gaps = 1/267 (0%) Query 16 GPRTK-IRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTT 74 GP T+ +RT L K G KW+MLT+YD TA IFD AGIPVLLVGDSAAN V+GY+TT Sbjct 15 GPATRRVRTRDLLAAKERGEKWSMLTSYDQYTASIFDAAGIPVLLVGDSAANNVFGYETT 74 Query 75 VPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEG 134 +P++ +EL+PLVR VVR ALVV DLPFGSYE GPT AL A RF+K+GG HAVKLEG Sbjct 75 LPVTTEELLPLVRAVVRATRQALVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEG 134 Query 135 GERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAF 194 G R A+QIA + AGIPVMAHIGFTPQS +TLGG+RVQGRGD A++ ADA+AVAEAGAF Sbjct 135 GRRCADQIATIVGAGIPVMAHIGFTPQSEHTLGGYRVQGRGDTADEVFADALAVAEAGAF 194 Query 195 AVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADV 254 AVV+EMVP E+A +ITG+L+IPTVGIGAGP+ D QVLVWQDMAG K RFVKRYAD+ Sbjct 195 AVVLEMVPGEVAKRITGELSIPTVGIGAGPDTDAQVLVWQDMAGLRTGKAPRFVKRYADL 254 Query 255 GGELRRAAMQYAQEVAGGVFPADEHSF 281 G L A ++A EV GG FPA EH+F Sbjct 255 AGALAEATQRFADEVRGGEFPAAEHTF 281 >gi|134098188|ref|YP_001103849.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|291009120|ref|ZP_06567093.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|158513549|sp|A4FA49.1|PANB_SACEN RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT gi|133910811|emb|CAM00924.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=293 Score = 362 bits (928), Expect = 5e-98, Method: Compositional matrix adjust. Identities = 184/271 (68%), Positives = 210/271 (78%), Gaps = 1/271 (0%) Query 12 PGGSGPRTKIRTH-HLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYG 70 P GS PR + HL K G W MLT+YD TARIFDEAGIPVLLVGDSAAN VYG Sbjct 22 PYGSAPRRRRVRTRHLLELKQRGEAWPMLTSYDMYTARIFDEAGIPVLLVGDSAANNVYG 81 Query 71 YDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAV 130 YDTTVP++++ELIPLVR V RGA ALVVADLPFGSYEA P ALA A RF+K+GGAHAV Sbjct 82 YDTTVPVTVEELIPLVRAVTRGARSALVVADLPFGSYEASPEQALATAVRFMKEGGAHAV 141 Query 131 KLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAE 190 KLEGG A + L AGIPVM HIGFTPQS +TLGG+RVQGRG+ AE+ ADA A+ + Sbjct 142 KLEGGRPFARHVEALVNAGIPVMGHIGFTPQSEHTLGGYRVQGRGEQAEELAADARALQD 201 Query 191 AGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKR 250 AGAFAVV+EMV ++ A ++T +LTIPTVGIGAGP CD QVLVW DMAG + +TARFVKR Sbjct 202 AGAFAVVLEMVSSDSAKRVTAELTIPTVGIGAGPECDAQVLVWTDMAGMNTGRTARFVKR 261 Query 251 YADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 YAD+GG L RAA ++A EV GG FPA EHSF Sbjct 262 YADLGGTLARAAQEFADEVRGGAFPAPEHSF 292 >gi|302869088|ref|YP_003837725.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Micromonospora aurantiaca ATCC 27029] gi|315504439|ref|YP_004083326.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Micromonospora sp. L5] gi|302571947|gb|ADL48149.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Micromonospora aurantiaca ATCC 27029] gi|315411058|gb|ADU09175.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Micromonospora sp. L5] Length=281 Score = 358 bits (918), Expect = 6e-97, Method: Compositional matrix adjust. Identities = 177/267 (67%), Positives = 210/267 (79%), Gaps = 1/267 (0%) Query 16 GPRTK-IRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTT 74 GP T+ +RT L K G +WAMLT+YD TA IFD+AGIPVLLVGDSAAN V+GY+TT Sbjct 15 GPATRRVRTRDLIAAKERGERWAMLTSYDQYTASIFDQAGIPVLLVGDSAANNVFGYETT 74 Query 75 VPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEG 134 +P++ +EL+PLVR VVR H+L+V DLPFGSYE GP AL A RF+K+GG HAVKLEG Sbjct 75 LPVTAEELLPLVRAVVRATKHSLIVGDLPFGSYEEGPAQALRTAVRFMKEGGCHAVKLEG 134 Query 135 GERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAF 194 G R A QI +T AGIPVMAHIGFTPQS +TLGG+RVQGRG+AAE+ +ADA AVAEAGAF Sbjct 135 GRRCAAQIEAITGAGIPVMAHIGFTPQSEHTLGGYRVQGRGEAAEEVLADARAVAEAGAF 194 Query 195 AVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADV 254 AVV+EMVP E+A ++T +L IPTVGIGAGP+ DGQVLVWQDMAG + RFVKRYAD+ Sbjct 195 AVVLEMVPGEVAKRVTAELPIPTVGIGAGPDTDGQVLVWQDMAGLRTGRAPRFVKRYADL 254 Query 255 GGELRRAAMQYAQEVAGGVFPADEHSF 281 G L A ++A EV GG FPA EH+F Sbjct 255 AGALTDATRRFADEVRGGEFPAAEHTF 281 >gi|330469436|ref|YP_004407179.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Verrucosispora maris AB-18-032] gi|328812407|gb|AEB46579.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Verrucosispora maris AB-18-032] Length=281 Score = 357 bits (915), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 179/267 (68%), Positives = 207/267 (78%), Gaps = 1/267 (0%) Query 16 GPRTK-IRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTT 74 GP T+ +RT L K G KWAMLT+YD TA IFD AGIPVLLVGDSAAN V+GY+TT Sbjct 15 GPATRRVRTRDLIAAKERGEKWAMLTSYDQYTASIFDAAGIPVLLVGDSAANNVFGYETT 74 Query 75 VPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEG 134 +P++ +EL+PLVR VVR LVV DLPFGSYE GPT AL A RF+K+GG HAVKLEG Sbjct 75 LPVTAEELLPLVRAVVRATRQTLVVGDLPFGSYEEGPTQALRTAVRFMKEGGCHAVKLEG 134 Query 135 GERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAF 194 G R A+QIA + AGIPVMAHIGFTPQS + LGG+RVQGRGDAAE+ +ADA AVAEAGAF Sbjct 135 GRRCADQIAAIVGAGIPVMAHIGFTPQSEHNLGGYRVQGRGDAAEEVVADARAVAEAGAF 194 Query 195 AVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADV 254 AVV+EMVP +A +ITG+L+IPTVGIGAGP D QVLVWQDMAG + RFVKRYAD+ Sbjct 195 AVVLEMVPGAVAKRITGELSIPTVGIGAGPETDAQVLVWQDMAGLRTGRAPRFVKRYADL 254 Query 255 GGELRRAAMQYAQEVAGGVFPADEHSF 281 G L A ++A EV GG FPA EH+F Sbjct 255 AGALGEATRRFADEVRGGEFPAAEHTF 281 >gi|158564089|sp|Q0RFD5.2|PANB_FRAAA RecName: Full=3-methyl-2-oxobutanoate hydroxymethyltransferase; AltName: Full=Ketopantoate hydroxymethyltransferase; Short=KPHMT Length=303 Score = 355 bits (911), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 177/277 (64%), Positives = 213/277 (77%), Gaps = 0/277 (0%) Query 5 TIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSA 64 T+YGA S R++ + K+ G +W+MLTAYD++TA +FDEA IPVLLVGDSA Sbjct 27 TLYGAPAETRSPRRSRFTVRDVAAAKSRGERWSMLTAYDFTTATVFDEAEIPVLLVGDSA 86 Query 65 ANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKD 124 ANVVYGYDTTVP+++DELIPLVR VVRGAPHA+VVADLPFGSY+AGP ALA ATRFLK+ Sbjct 87 ANVVYGYDTTVPVTVDELIPLVRAVVRGAPHAMVVADLPFGSYQAGPEQALATATRFLKE 146 Query 125 GGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIAD 184 GGA AVKLEGG RVA +A L AGIPV+ H+G TPQS++ LGG+RVQGR +A E +AD Sbjct 147 GGAQAVKLEGGARVAPAVAALVGAGIPVIGHLGLTPQSIHALGGYRVQGRDEAGEVLLAD 206 Query 185 AIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKT 244 A+A+ AGAFAVV+E+VPA+LA ++T +L I TVGIGAG +CD QVLVWQDMAG SG Sbjct 207 ALAIEAAGAFAVVLEVVPADLAARVTKELHIATVGIGAGADCDAQVLVWQDMAGLSGGHV 266 Query 245 ARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 RFVKRYAD+ L A Y EV GG +P EHS+ Sbjct 267 PRFVKRYADLRTVLGDAVRTYRDEVRGGQYPTVEHSY 303 >gi|257054800|ref|YP_003132632.1| ketopantoate hydroxymethyltransferase [Saccharomonospora viridis DSM 43017] gi|256584672|gb|ACU95805.1| ketopantoate hydroxymethyltransferase [Saccharomonospora viridis DSM 43017] Length=299 Score = 354 bits (909), Expect = 7e-96, Method: Compositional matrix adjust. Identities = 169/274 (62%), Positives = 206/274 (76%), Gaps = 0/274 (0%) Query 8 GANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANV 67 G T + PR ++R HHL+ K G W MLTAYD TAR+FDEAGIPVLLVGDSAAN Sbjct 25 GTPTESATPPRKRVRIHHLRELKERGEPWPMLTAYDTYTARLFDEAGIPVLLVGDSAANT 84 Query 68 VYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGA 127 VYGY++++PI+++E++PLVR V R ALVVADLPFGSY+ P A+A A RF+K+G A Sbjct 85 VYGYESSLPITVEEMLPLVRAVTRSVSKALVVADLPFGSYQVSPEQAVATAARFMKEGRA 144 Query 128 HAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIA 187 HAVKLEGG + A + +TAAG+PVM HIGFTPQS + LGG+RVQGRGD + IADA+A Sbjct 145 HAVKLEGGRKFAPHVEAVTAAGVPVMGHIGFTPQSEHNLGGYRVQGRGDTGDALIADALA 204 Query 188 VAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARF 247 + +AGAFAVVMEMVPAE+A QIT +L IPTVGIGAGP+CD QVLVWQDMAG + RF Sbjct 205 LQDAGAFAVVMEMVPAEIAKQITHELHIPTVGIGAGPDCDAQVLVWQDMAGLRTGRVPRF 264 Query 248 VKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 VK+YAD+ G L A +A +V FPA EH+F Sbjct 265 VKQYADLAGVLTTAVKAFADDVRNRTFPAPEHTF 298 >gi|300783135|ref|YP_003763426.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Amycolatopsis mediterranei U32] gi|299792649|gb|ADJ43024.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Amycolatopsis mediterranei U32] gi|340524514|gb|AEK39719.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Amycolatopsis mediterranei S699] Length=289 Score = 352 bits (903), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 170/262 (65%), Positives = 203/262 (78%), Gaps = 0/262 (0%) Query 20 KIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISI 79 K+R HHL+ K G W MLTAYD TA +FDEAGIPVLLVGDSAAN V+GYDT++P+++ Sbjct 26 KVRVHHLRELKERGEPWPMLTAYDMYTAALFDEAGIPVLLVGDSAANNVFGYDTSLPVTV 85 Query 80 DELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVA 139 DEL+PLVR V R ALVVADLPFGSY+ P AL + RF+K+G AHAVKLEGG R A Sbjct 86 DELLPLVRAVTRSVKRALVVADLPFGSYQLSPQQALETSVRFMKEGRAHAVKLEGGRRFA 145 Query 140 EQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVME 199 + LT+AG+PVM HIGFTPQS + LGG+RVQGRG+AA+ +ADA+A+ EAGAFAVVME Sbjct 146 AHVEALTSAGVPVMGHIGFTPQSEHNLGGYRVQGRGEAADVLLADALALQEAGAFAVVME 205 Query 200 MVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELR 259 MVPAE A ++T +L IPTVGIGAGP+CD QVLVWQDMAG K RFVKRYADV L+ Sbjct 206 MVPAEAAKRVTAELKIPTVGIGAGPDCDAQVLVWQDMAGLRRGKAPRFVKRYADVATVLQ 265 Query 260 RAAMQYAQEVAGGVFPADEHSF 281 AA +A++V G FPA EH+F Sbjct 266 DAATAFAEDVRRGEFPAPEHAF 287 >gi|312195606|ref|YP_004015667.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Frankia sp. EuI1c] gi|311226942|gb|ADP79797.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Frankia sp. EuI1c] Length=308 Score = 350 bits (899), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 180/288 (63%), Positives = 216/288 (75%), Gaps = 11/288 (3%) Query 5 TIYGANTPGG-----------SGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEA 53 T+YGA+TP S PR + L WK KWAMLTAYDY+TA IFDEA Sbjct 20 TLYGASTPTTDRQATDRPAEPSKPRRRPTVRDLATWKDRHEKWAMLTAYDYTTASIFDEA 79 Query 54 GIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTA 113 +PVLLVGDSAANVVYGYDTTVP+S+DEL+PLVRGVVRGAPHA+VVADLPFGSY+A P Sbjct 80 EVPVLLVGDSAANVVYGYDTTVPVSVDELLPLVRGVVRGAPHAMVVADLPFGSYQASPAQ 139 Query 114 ALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQG 173 AL ATRFLK+GGA AVKLEGG RVA Q+ L +AGIPVM H+G TPQS+NTLGG+RVQG Sbjct 140 ALETATRFLKEGGAQAVKLEGGARVAPQVDLLVSAGIPVMGHLGLTPQSINTLGGYRVQG 199 Query 174 RGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVW 233 R DA +ADA A+ AGAFAVV+E+VP+++A +I+ LTIPTVGIGAG +CD QVLVW Sbjct 200 RDDAGAALLADAQAIEAAGAFAVVLEVVPSDVAARISKALTIPTVGIGAGSDCDAQVLVW 259 Query 234 QDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 QDMAG + + RFV+R+A++ LR AA Y +V G +P E+S+ Sbjct 260 QDMAGLTSGRAPRFVRRFAELRTPLRDAARAYVADVRDGHYPTVEYSY 307 >gi|324998644|ref|ZP_08119756.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Pseudonocardia sp. P1] Length=290 Score = 350 bits (898), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 168/262 (65%), Positives = 209/262 (80%), Gaps = 0/262 (0%) Query 20 KIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISI 79 + R HHL +WK +G +W MLTAYD +A IFD+AGIPVLLVGDSA N V+G+D T+P++I Sbjct 28 RTRVHHLTQWKQEGRRWPMLTAYDVYSAEIFDDAGIPVLLVGDSAGNNVFGHDNTIPVTI 87 Query 80 DELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVA 139 D+L+PL R VVRGA ALVVADLPFGSY+ P A +A RF+K+ GAHAVKLEGG R A Sbjct 88 DDLLPLTRAVVRGARSALVVADLPFGSYQISPAQAQESAFRFMKEAGAHAVKLEGGARFA 147 Query 140 EQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVME 199 QI LTA+G+PVM H+GFTPQS + LGGFR+QGRGDAA+ + DA+AV EAGAFAVV+E Sbjct 148 PQIEALTASGVPVMGHLGFTPQSEHALGGFRIQGRGDAADALVEDALAVQEAGAFAVVLE 207 Query 200 MVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELR 259 MVPA++A ++TG+L IPTVGIGAGP+CDGQVLVW DMAG + + RFV+RYA+VG L Sbjct 208 MVPADVAKRVTGELRIPTVGIGAGPDCDGQVLVWSDMAGMNRGRVPRFVRRYAEVGSVLH 267 Query 260 RAAMQYAQEVAGGVFPADEHSF 281 AA +A +V GG +PA+EHS+ Sbjct 268 DAAAAFAADVRGGEYPAEEHSY 289 >gi|284991821|ref|YP_003410375.1| 3-methyl-2-oxobutanoatehydroxymethyltransferase [Geodermatophilus obscurus DSM 43160] gi|284065066|gb|ADB76004.1| 3-methyl-2-oxobutanoatehydroxymethyltransferase [Geodermatophilus obscurus DSM 43160] Length=276 Score = 350 bits (897), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 171/281 (61%), Positives = 209/281 (75%), Gaps = 6/281 (2%) Query 1 MSEQTIYGANTPGGSGPRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLV 60 M+E +YG + ++R HHLQ+ K G KWAMLTAYD +A +F+EAGIPV+LV Sbjct 1 MTESVLYGGTSTA------RVRVHHLQQAKERGEKWAMLTAYDTFSATVFEEAGIPVMLV 54 Query 61 GDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATR 120 GDSA NVV G+ +TVP+++++++ + + V R AL+VADLPFGSYEA P A A A R Sbjct 55 GDSAGNVVLGHTSTVPVTVEDILGMTKAVTRSTKRALIVADLPFGSYEASPQQAFATAVR 114 Query 121 FLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQ 180 LK+GGA AVKLEGG RVA Q LT GIPVMAH+GFTPQS + LGGFRVQGRG AEQ Sbjct 115 MLKEGGAQAVKLEGGVRVAPQTRMLTENGIPVMAHVGFTPQSEHALGGFRVQGRGAGAEQ 174 Query 181 TIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFS 240 + DA AV EAGAFAVV+EMVPAE+A Q+T +L+IPT+GIGAG +CD QVLVW DMAG + Sbjct 175 LLTDAHAVQEAGAFAVVLEMVPAEIAAQVTKELSIPTIGIGAGVDCDAQVLVWPDMAGLT 234 Query 241 GAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 + RFVK+YAD+ GEL RAA +YA EV GVFP EHSF Sbjct 235 SGRVPRFVKKYADLRGELLRAAREYADEVRSGVFPGPEHSF 275 >gi|158313598|ref|YP_001506106.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Frankia sp. EAN1pec] gi|158109003|gb|ABW11200.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Frankia sp. EAN1pec] Length=313 Score = 349 bits (896), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 182/292 (63%), Positives = 217/292 (75%), Gaps = 17/292 (5%) Query 5 TIYGA-NTP--GGSGP------------RTKIRTHHLQRWKADGHKWAMLTAYDYSTARI 49 T+YGA TP GG P RT +R ++ K G +WAMLTAYD TA I Sbjct 24 TLYGAPTTPRTGGQAPATPTTIRPASHSRTTVR--DIRAAKDRGQRWAMLTAYDVITAGI 81 Query 50 FDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEA 109 FDEAGIPVLLVGDSAAN VYGY+TTVPI++DEL+PLVR VVRGAPHA+VVADLPFGSY+A Sbjct 82 FDEAGIPVLLVGDSAANTVYGYETTVPITVDELVPLVRAVVRGAPHAMVVADLPFGSYQA 141 Query 110 GPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGF 169 P AL ATRFLK+GGAHAVKLEGG RV Q+ L AAGIPVM H+G TPQSV+ GG+ Sbjct 142 SPEQALTTATRFLKEGGAHAVKLEGGARVLPQVGALVAAGIPVMGHLGLTPQSVHAFGGY 201 Query 170 RVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQ 229 RVQGR A E +ADA+ + EAGAFAVV+E+VPA+LA ++T +L I TVGIGAG +CD Q Sbjct 202 RVQGRDGAGEVLLADALGLQEAGAFAVVLEVVPADLAARVTKELLISTVGIGAGADCDAQ 261 Query 230 VLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 VLVWQDMAG +G + RFVKR+AD+ L AA + EV+GG++P EHS+ Sbjct 262 VLVWQDMAGLTGGQAPRFVKRFADLRTALTDAAAAFRDEVSGGLYPTVEHSY 313 >gi|84496749|ref|ZP_00995603.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Janibacter sp. HTCC2649] gi|84383517|gb|EAP99398.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Janibacter sp. HTCC2649] Length=289 Score = 347 bits (889), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 174/287 (61%), Positives = 209/287 (73%), Gaps = 6/287 (2%) Query 1 MSEQTIYGANT--PGGSG----PRTKIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAG 54 MS+Q A T P G+G P+ +IR HLQ+ K G KWAMLTAYD A IFDEAG Sbjct 1 MSDQPTPPAETINPYGTGAQAAPQKRIRVPHLQKMKETGEKWAMLTAYDMYAAEIFDEAG 60 Query 55 IPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAA 114 IP LLVGDSA N VYG++TTVP+++D L+PL R V A HA+VVADLPFGSY+A P A Sbjct 61 IPCLLVGDSAGNNVYGFETTVPVTVDHLVPLCRAVTSAAKHAMVVADLPFGSYQASPQQA 120 Query 115 LAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGR 174 LA ATRF+K+G AHAVKLEGG+ + +I L AGIPVM HIGFTPQS + LGG+RVQGR Sbjct 121 LATATRFMKEGLAHAVKLEGGKAMVPEIELLVRAGIPVMGHIGFTPQSEHVLGGYRVQGR 180 Query 175 GDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQ 234 GD A++ + DA+A+ AG FA+V+EMVPA A ++T L IP +GIGAGP+CD QVLVWQ Sbjct 181 GDGADRLLEDALALEAAGCFAIVIEMVPAPAAKKVTEALRIPIIGIGAGPDCDAQVLVWQ 240 Query 235 DMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 DMAG G + RFVK+Y D+ L AA +YA EVA G FPA EHSF Sbjct 241 DMAGLRGGRAPRFVKKYMDMRTGLADAAKEYAAEVASGAFPAAEHSF 287 >gi|152967242|ref|YP_001363026.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Kineococcus radiotolerans SRS30216] gi|151361759|gb|ABS04762.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Kineococcus radiotolerans SRS30216] Length=276 Score = 345 bits (884), Expect = 5e-93, Method: Compositional matrix adjust. Identities = 172/258 (67%), Positives = 202/258 (79%), Gaps = 1/258 (0%) Query 24 HHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELI 83 HH Q+WK G KWAMLT+YD TA +FDEAGIP LLVGDSAAN V+G TT+P+++D L+ Sbjct 20 HHFQQWKDAGEKWAMLTSYDAMTAAVFDEAGIPALLVGDSAANTVFGMPTTLPVTLDHLL 79 Query 84 PLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIA 143 PLVR VV GAPHA VVADLPFGSYE A+A+A R +K+GGAHAVK EGG R A ++ Sbjct 80 PLVRAVVAGAPHAFVVADLPFGSYEVSDDLAVASAVRVMKEGGAHAVKFEGGARRAGRVR 139 Query 144 CLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVMEMVPA 203 + AGIPVMAHIGFTPQS + LGG+RVQGRG+A EQ +ADA A+AEAGAFAV+MEMVPA Sbjct 140 AVVEAGIPVMAHIGFTPQSEHALGGYRVQGRGEAGEQVLADARALAEAGAFAVLMEMVPA 199 Query 204 ELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAM 263 ++A Q+T L +PTVGIGAG DGQVLVWQD AG S +TA+FVKR+ADV L AA Sbjct 200 DVAAQVTRTLAVPTVGIGAGSGTDGQVLVWQDFAGLS-ERTAKFVKRFADVRTALSDAAR 258 Query 264 QYAQEVAGGVFPADEHSF 281 QYA+EV GG FP EHSF Sbjct 259 QYAEEVRGGSFPGPEHSF 276 >gi|311742910|ref|ZP_07716718.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Aeromicrobium marinum DSM 15272] gi|311313590|gb|EFQ83499.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Aeromicrobium marinum DSM 15272] Length=287 Score = 343 bits (881), Expect = 1e-92, Method: Compositional matrix adjust. Identities = 176/275 (64%), Positives = 209/275 (76%), Gaps = 5/275 (1%) Query 12 PGGSGPRT-----KIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAAN 66 P G GP T ++RTHHL++WKADG KWAMLTAYD A++FDEAGIPVLLVGDSA+N Sbjct 11 PYGGGPTTDPTVKRVRTHHLRQWKADGEKWAMLTAYDQYAAQVFDEAGIPVLLVGDSASN 70 Query 67 VVYGYDTTVPISIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGG 126 VYG ++++P+++DELIPLVR V R A ALVVADLPFGSY+ P A A RF+K+ Sbjct 71 NVYGNESSLPVTVDELIPLVRAVTRSAQRALVVADLPFGSYQGSPQQAFDTAVRFMKEAD 130 Query 127 AHAVKLEGGERVAEQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAI 186 AHAVKLEGG +A Q+ LT GIPVMAHIGFTPQS + LGG+RVQGRGDAA++ I +A+ Sbjct 131 AHAVKLEGGLPMAPQVQLLTDGGIPVMAHIGFTPQSEHQLGGYRVQGRGDAAQRLIEEAV 190 Query 187 AVAEAGAFAVVMEMVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTAR 246 A+ EAGAFAVVMEMVPA +A Q+T L IPT+GIGAG CD QVLVWQDM G + R Sbjct 191 ALQEAGAFAVVMEMVPAPVAAQVTDVLRIPTIGIGAGAACDAQVLVWQDMMGLRTGRAPR 250 Query 247 FVKRYADVGGELRRAAMQYAQEVAGGVFPADEHSF 281 FVKRYAD+ G + AA YA +VA G FPADEH F Sbjct 251 FVKRYADLHGVMLGAARAYAADVAAGTFPADEHRF 285 >gi|331697750|ref|YP_004333989.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Pseudonocardia dioxanivorans CB1190] gi|326952439|gb|AEA26136.1| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Pseudonocardia dioxanivorans CB1190] Length=292 Score = 342 bits (878), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 165/262 (63%), Positives = 199/262 (76%), Gaps = 0/262 (0%) Query 20 KIRTHHLQRWKADGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISI 79 + R HHL K G +W MLTAYD A IFDEAGIPVLLVGDSA N V+GYD T+P+++ Sbjct 31 RTRIHHLAEMKQRGERWPMLTAYDRYAAEIFDEAGIPVLLVGDSAGNNVFGYDNTIPVTV 90 Query 80 DELIPLVRGVVRGAPHALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVA 139 DEL+PLV+ VV GAP+ALVVADLPFGSY+ P L RF+K+GGAHAVKLEGG R A Sbjct 91 DELMPLVKAVVGGAPNALVVADLPFGSYQVSPAQGLETGIRFMKEGGAHAVKLEGGARFA 150 Query 140 EQIACLTAAGIPVMAHIGFTPQSVNTLGGFRVQGRGDAAEQTIADAIAVAEAGAFAVVME 199 + L +GIPVMAHIGFTPQ + LGGFR+QGRGDA ++ I DA+A+ EAGAFAVV+E Sbjct 151 PHVEALAGSGIPVMAHIGFTPQHEHALGGFRIQGRGDAGDRLIEDALALQEAGAFAVVLE 210 Query 200 MVPAELATQITGKLTIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELR 259 MVPA++A ++TG+L IPTVGIGAGP+CD QVLVW DMAG + + RFVK YAD+G L Sbjct 211 MVPADVAKRVTGELRIPTVGIGAGPDCDAQVLVWSDMAGMNRGRKPRFVKPYADLGSILL 270 Query 260 RAAMQYAQEVAGGVFPADEHSF 281 AA YA +V GG +P EHS+ Sbjct 271 DAAKAYAADVRGGEYPDAEHSY 292 Lambda K H 0.319 0.135 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 445900241072 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40