BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv2265

Length=409
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|15609402|ref|NP_216781.1|  integral membrane protein [Mycobact...   780    0.0   
gi|289754371|ref|ZP_06513749.1|  integral membrane protein [Mycob...   778    0.0   
gi|289443776|ref|ZP_06433520.1|  conserved membrane protein [Myco...   776    0.0   
gi|289762428|ref|ZP_06521806.1|  conserved hypothetical protein [...   652    0.0   
gi|289750865|ref|ZP_06510243.1|  LOW QUALITY PROTEIN: conserved m...   648    0.0   
gi|240170105|ref|ZP_04748764.1|  putative transmembrane protein [...   496    2e-138
gi|169631689|ref|YP_001705338.1|  major facilitator transporter [...   466    4e-129
gi|297162994|gb|ADI12706.1|  major facilitator transporter [Strep...   418    9e-115
gi|120403762|ref|YP_953591.1|  major facilitator superfamily tran...   363    4e-98 
gi|86741018|ref|YP_481418.1|  major facilitator transporter [Fran...   352    8e-95 
gi|336119617|ref|YP_004574394.1|  putative major facilitator supe...   306    4e-81 
gi|317126650|ref|YP_004100762.1|  major facilitator superfamily M...   283    4e-74 
gi|297618483|ref|YP_003703642.1|  major facilitator superfamily p...   279    8e-73 
gi|119487499|ref|ZP_01621109.1|  hypothetical protein L8106_26622...   278    9e-73 
gi|221632591|ref|YP_002521812.1|  hypothetical protein trd_0566 [...   277    2e-72 
gi|333980028|ref|YP_004517973.1|  major facilitator superfamily p...   277    3e-72 
gi|269926659|ref|YP_003323282.1|  major facilitator superfamily M...   273    4e-71 
gi|338174078|ref|YP_004650888.1|  protein Mb2288 [Parachlamydia a...   271    1e-70 
gi|163849334|ref|YP_001637378.1|  major facilitator transporter [...   271    1e-70 
gi|339500890|ref|YP_004698925.1|  major facilitator superfamily p...   269    6e-70 
gi|154248866|ref|YP_001409691.1|  major facilitator transporter [...   269    7e-70 
gi|75906469|ref|YP_320765.1|  major facilitator transporter [Anab...   268    1e-69 
gi|119715785|ref|YP_922750.1|  major facilitator transporter [Noc...   266    6e-69 
gi|17229926|ref|NP_486474.1|  hypothetical protein alr2434 [Nosto...   265    1e-68 
gi|11499136|ref|NP_070370.1|  hypothetical protein AF1541 [Archae...   264    3e-68 
gi|218437727|ref|YP_002376056.1|  major facilitator superfamily p...   262    1e-67 
gi|328954411|ref|YP_004371745.1|  major facilitator superfamily M...   261    1e-67 
gi|219850575|ref|YP_002465008.1|  major facilitator superfamily p...   261    1e-67 
gi|307153821|ref|YP_003889205.1|  major facilitator superfamily p...   259    4e-67 
gi|345302473|ref|YP_004824375.1|  major facilitator superfamily p...   259    6e-67 
gi|145594879|ref|YP_001159176.1|  major facilitator transporter [...   259    8e-67 
gi|126178383|ref|YP_001046348.1|  major facilitator transporter [...   258    1e-66 
gi|206890274|ref|YP_002249597.1|  hypothetical protein THEYE_A180...   258    2e-66 
gi|268316173|ref|YP_003289892.1|  major facilitator superfamily p...   257    2e-66 
gi|282890426|ref|ZP_06298953.1|  hypothetical protein pah_c017o00...   257    2e-66 
gi|332668938|ref|YP_004451946.1|  major facilitator superfamily p...   255    1e-65 
gi|260893310|ref|YP_003239407.1|  major facilitator superfamily M...   254    1e-65 
gi|337288257|ref|YP_004627729.1|  major facilitator superfamily p...   254    1e-65 
gi|333896447|ref|YP_004470321.1|  major facilitator superfamily M...   254    2e-65 
gi|160901703|ref|YP_001567284.1|  major facilitator transporter [...   253    5e-65 
gi|159038076|ref|YP_001537329.1|  major facilitator transporter [...   253    6e-65 
gi|222099533|ref|YP_002534101.1|  Major facilitator superfamily M...   252    8e-65 
gi|304439966|ref|ZP_07399859.1|  major facilitator family transpo...   251    1e-64 
gi|288817525|ref|YP_003431872.1|  permease of the major facilitat...   251    1e-64 
gi|15642905|ref|NP_227946.1|  hypothetical protein TM0130 [Thermo...   250    3e-64 
gi|313673903|ref|YP_004052014.1|  major facilitator superfamily m...   250    3e-64 
gi|206895704|ref|YP_002246633.1|  hypothetical protein COPRO5265_...   248    2e-63 
gi|116669256|ref|YP_830189.1|  major facilitator transporter [Art...   246    4e-63 
gi|157363592|ref|YP_001470359.1|  major facilitator transporter [...   244    1e-62 
gi|148269929|ref|YP_001244389.1|  major facilitator transporter [...   244    2e-62 


>gi|15609402|ref|NP_216781.1| integral membrane protein [Mycobacterium tuberculosis H37Rv]
 gi|15841758|ref|NP_336795.1| hypothetical protein MT2327 [Mycobacterium tuberculosis CDC1551]
 gi|31793444|ref|NP_855937.1| integral membrane protein [Mycobacterium bovis AF2122/97]
 72 more sequence titles
 Length=409

 Score =  780 bits (2014),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 408/409 (99%), Positives = 409/409 (100%), Gaps = 0/409 (0%)

Query  1    VGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV  60
            +GANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV
Sbjct  1    MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV  60

Query  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120
            GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI
Sbjct  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120

Query  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180
            AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA
Sbjct  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180

Query  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240
            PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA
Sbjct  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240

Query  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300
            ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL
Sbjct  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300

Query  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG  360
            PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG
Sbjct  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG  360

Query  361  LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409
            LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS
Sbjct  361  LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409


>gi|289754371|ref|ZP_06513749.1| integral membrane protein [Mycobacterium tuberculosis EAS054]
 gi|289694958|gb|EFD62387.1| integral membrane protein [Mycobacterium tuberculosis EAS054]
Length=409

 Score =  778 bits (2010),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 407/409 (99%), Positives = 408/409 (99%), Gaps = 0/409 (0%)

Query  1    VGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV  60
            +GANGDVALSRIGATRPALSAWRFVTVFGVV LLADVVYEGARSITGPLLASLGATGLVV
Sbjct  1    MGANGDVALSRIGATRPALSAWRFVTVFGVVSLLADVVYEGARSITGPLLASLGATGLVV  60

Query  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120
            GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI
Sbjct  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120

Query  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180
            AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA
Sbjct  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180

Query  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240
            PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA
Sbjct  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240

Query  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300
            ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL
Sbjct  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300

Query  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG  360
            PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG
Sbjct  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG  360

Query  361  LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409
            LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS
Sbjct  361  LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409


>gi|289443776|ref|ZP_06433520.1| conserved membrane protein [Mycobacterium tuberculosis T46]
 gi|289570385|ref|ZP_06450612.1| conserved membrane protein [Mycobacterium tuberculosis T17]
 gi|289416695|gb|EFD13935.1| conserved membrane protein [Mycobacterium tuberculosis T46]
 gi|289544139|gb|EFD47787.1| conserved membrane protein [Mycobacterium tuberculosis T17]
Length=409

 Score =  776 bits (2005),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 406/409 (99%), Positives = 407/409 (99%), Gaps = 0/409 (0%)

Query  1    VGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV  60
            +GANGDVALSRIGATRPALSAWRF TVFGVV LLADVVYEGARSITGPLLASLGATGLVV
Sbjct  1    MGANGDVALSRIGATRPALSAWRFATVFGVVSLLADVVYEGARSITGPLLASLGATGLVV  60

Query  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120
            GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI
Sbjct  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120

Query  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180
            AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA
Sbjct  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180

Query  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240
            PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA
Sbjct  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240

Query  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300
            ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL
Sbjct  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300

Query  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG  360
            PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG
Sbjct  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAG  360

Query  361  LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409
            LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS
Sbjct  361  LGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409


>gi|289762428|ref|ZP_06521806.1| conserved hypothetical protein [Mycobacterium tuberculosis GM 
1503]
 gi|289709934|gb|EFD73950.1| conserved hypothetical protein [Mycobacterium tuberculosis GM 
1503]
Length=390

 Score =  652 bits (1682),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 339/340 (99%), Positives = 340/340 (100%), Gaps = 0/340 (0%)

Query  1    VGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV  60
            +GANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV
Sbjct  1    MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVV  60

Query  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120
            GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI
Sbjct  61   GVVTGVGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVI  120

Query  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180
            AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA
Sbjct  121  AERVGKAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYA  180

Query  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240
            PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA
Sbjct  181  PALGVLTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTA  240

Query  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300
            ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL
Sbjct  241  ITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVL  300

Query  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGV  340
            PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGV
Sbjct  301  PILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGV  340


>gi|289750865|ref|ZP_06510243.1| LOW QUALITY PROTEIN: conserved membrane protein [Mycobacterium 
tuberculosis T92]
 gi|289691452|gb|EFD58881.1| LOW QUALITY PROTEIN: conserved membrane protein [Mycobacterium 
tuberculosis T92]
Length=390

 Score =  648 bits (1671),  Expect = 0.0, Method: Compositional matrix adjust.
 Identities = 337/337 (100%), Positives = 337/337 (100%), Gaps = 0/337 (0%)

Query  73   GLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPA  132
            GLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPA
Sbjct  54   GLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPA  113

Query  133  KDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGA  192
            KDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGA
Sbjct  114  KDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGA  173

Query  193  ALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLL  252
            ALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLL
Sbjct  174  ALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLL  233

Query  253  SFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAF  312
            SFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAF
Sbjct  234  SFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAF  293

Query  313  TDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALI  372
            TDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALI
Sbjct  294  TDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALI  353

Query  373  GWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409
            GWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS
Sbjct  354  GWLYDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  390


>gi|240170105|ref|ZP_04748764.1| putative transmembrane protein [Mycobacterium kansasii ATCC 12478]
Length=404

 Score =  496 bits (1278),  Expect = 2e-138, Method: Compositional matrix adjust.
 Identities = 310/394 (79%), Positives = 347/394 (89%), Gaps = 3/394 (0%)

Query  19   LSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVS  78
            +SAWRFV VFGVV LLAD VYEGARSITGPLLASLGATGLVVGVVTG+GEAAAL LRLVS
Sbjct  1    MSAWRFVAVFGVVSLLADFVYEGARSITGPLLASLGATGLVVGVVTGIGEAAALALRLVS  60

Query  79   GPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLS  138
            GPLADR+RRFWAWT+AGY LT++TVPLLG+AGALWVAC+LVIAERVGKAVR PAKDTLLS
Sbjct  61   GPLADRTRRFWAWTVAGYALTLITVPLLGVAGALWVACSLVIAERVGKAVRSPAKDTLLS  120

Query  139  HAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLL  198
            HAASVTGRGRGFAVHEALDQVGA+IGPLTVAG+LA+TGN YAPALGVL LPG AALALLL
Sbjct  121  HAASVTGRGRGFAVHEALDQVGAVIGPLTVAGVLAVTGNDYAPALGVLALPGAAALALLL  180

Query  199  WLQRRVPRPESYEDCPVVLGNPS---APRPWALPAQFWLYCGFTAITMLGFGTFGLLSFH  255
            WL+ RVP P+SYE       +P    A R W LP +FWLYCGFTAITM GF TFGLLSFH
Sbjct  181  WLRVRVPHPDSYEAPAASAVSPDGVVAQRFWELPPRFWLYCGFTAITMSGFATFGLLSFH  240

Query  256  MVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDN  315
            MV+HG+L+AA VPVVYAAAMAADAL AL SG+SYDR+G K+LA LP+LS +VVLFAF+ N
Sbjct  241  MVTHGLLSAAAVPVVYAAAMAADALAALVSGYSYDRFGGKSLAALPLLSSMVVLFAFSGN  300

Query  316  VTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWL  375
              MVV+G L+WGAAVGIQESTLR VVAD+V +PRRASAYGVFAAGLGAA+A GGAL+GWL
Sbjct  301  TAMVVVGALLWGAAVGIQESTLRAVVADMVTAPRRASAYGVFAAGLGAASAAGGALVGWL  360

Query  376  YDISIGTLVVVVIALELMALVMMFAIRLPRVAPS  409
            Y+IS GT+VVVV+A++L+AL+ MF I LPR A S
Sbjct  361  YEISTGTVVVVVVAIQLVALLSMFTIGLPRAAAS  394


>gi|169631689|ref|YP_001705338.1| major facilitator transporter [Mycobacterium abscessus ATCC 19977]
 gi|169243656|emb|CAM64684.1| Major facilitator superfamily [Mycobacterium abscessus]
Length=395

 Score =  466 bits (1199),  Expect = 4e-129, Method: Compositional matrix adjust.
 Identities = 258/378 (69%), Positives = 302/378 (80%), Gaps = 0/378 (0%)

Query  19   LSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVS  78
            LSAWRFVT FGV+ +LAD+VYEGARSITGPLLASLGA+ LVVGVVTG+GEAAAL LRLVS
Sbjct  5    LSAWRFVTTFGVISMLADIVYEGARSITGPLLASLGASALVVGVVTGIGEAAALALRLVS  64

Query  79   GPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLS  138
            GPL DR+R+FWAWTI+GY LTVVTVP LG++  LW+A  LVIAERVGKAVR PAKDTLLS
Sbjct  65   GPLTDRTRKFWAWTISGYALTVVTVPFLGVSSVLWIAATLVIAERVGKAVRSPAKDTLLS  124

Query  139  HAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLL  198
            HA +VTGRG+GFAVHEA+DQ+GA+ GPL VAGMLA+T   Y P   +L LPGGA L LL 
Sbjct  125  HATAVTGRGKGFAVHEAMDQIGAITGPLLVAGMLALTHVNYLPTFAILALPGGATLLLLF  184

Query  199  WLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVS  258
            WL+RRVP PE YE    + G    P   +LP  FWLY GFTAITM+GF TFG+LSFHMV 
Sbjct  185  WLRRRVPHPERYEHDDYIRGAADRPHKLSLPLSFWLYSGFTAITMIGFATFGVLSFHMVQ  244

Query  259  HGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTM  318
             GVL    VP+VYAAAMAADA+ AL SG++YDR G K+LA LPI+   V + AFTD++  
Sbjct  245  RGVLPVPAVPIVYAAAMAADAVAALLSGWAYDRVGPKSLAALPIVGATVPMLAFTDSLPG  304

Query  319  VVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDI  378
            +V+G L+WGAAVGIQESTLR VVADLV  PRRA+AYGV+AA LG ATA GGAL G+LY +
Sbjct  305  IVLGALLWGAAVGIQESTLRAVVADLVPPPRRATAYGVYAAVLGTATAIGGALTGYLYGV  364

Query  379  SIGTLVVVVIALELMALV  396
            SI  L+ VV  ++L+AL+
Sbjct  365  SIPMLIAVVGVIQLVALI  382


>gi|297162994|gb|ADI12706.1| major facilitator transporter [Streptomyces bingchenggensis BCW-1]
Length=402

 Score =  418 bits (1074),  Expect = 9e-115, Method: Compositional matrix adjust.
 Identities = 235/378 (63%), Positives = 273/378 (73%), Gaps = 7/378 (1%)

Query  15   TRPA---LSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAA  71
            +RPA   L  W FV  FG+V LLADVVYEGARSITGPLLASLGA+  VVGVVTG GEAAA
Sbjct  2    SRPASAGLRPWPFVVTFGIVSLLADVVYEGARSITGPLLASLGASATVVGVVTGAGEAAA  61

Query  72   LGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGP  131
            LGLRL+ GPLADR+ RFW  TI GY LT VTVPLLG AG LW AC LV+AER GKAVR P
Sbjct  62   LGLRLIFGPLADRTGRFWTLTITGYVLTAVTVPLLGTAGVLWAACVLVVAERTGKAVRSP  121

Query  132  AKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGG  191
            AKDTLLSHA + TGRGRGF VHEALDQ GA+IGPL VAG+LA+TGN Y PAL VL  PG 
Sbjct  122  AKDTLLSHATAATGRGRGFGVHEALDQTGAVIGPLVVAGILAVTGNDYTPALAVLAAPGI  181

Query  192  AALALLLWLQRRVPRP-ESYE-DCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTF  249
            AA+ LLLWL+ RVP P ++YE D     G P   R   LP  FW Y  FT +T  G  TF
Sbjct  182  AAVLLLLWLRARVPDPLDAYESDGESATGPPV--RVTRLPRAFWTYAAFTGVTTTGLATF  239

Query  250  GLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVL  309
            G+LS+H+V+  +LA   VP++YA AM    L ALA+G+ YDR GA+TLAVLP+L+  V  
Sbjct  240  GVLSYHLVTRRLLAPDAVPLLYAGAMLTAGLAALATGWLYDRTGARTLAVLPLLTAAVPA  299

Query  310  FAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGG  369
             AF   +   V G+L+WGAAVG+QES LR  VADLV + RRA+AYG+FA  LG A+  GG
Sbjct  300  LAFAHTLPAAVAGSLLWGAAVGMQESVLRATVADLVPAGRRATAYGIFAGVLGVASLAGG  359

Query  370  ALIGWLYDISIGTLVVVV  387
             L G LY +S+  L+ VV
Sbjct  360  TLTGALYAVSVHALITVV  377


>gi|120403762|ref|YP_953591.1| major facilitator superfamily transporter [Mycobacterium vanbaalenii 
PYR-1]
 gi|119956580|gb|ABM13585.1| major facilitator superfamily MFS_1 [Mycobacterium vanbaalenii 
PYR-1]
Length=398

 Score =  363 bits (931),  Expect = 4e-98, Method: Compositional matrix adjust.
 Identities = 252/386 (66%), Positives = 291/386 (76%), Gaps = 2/386 (0%)

Query  19   LSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVS  78
            LSAWRFVT FGVV LLAD+VYEGARSITGPLLASLGAT +VVGVVTGVGEAAAL LR+VS
Sbjct  9    LSAWRFVTTFGVVSLLADIVYEGARSITGPLLASLGATAVVVGVVTGVGEAAALILRMVS  68

Query  79   GPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLS  138
            GPLADR+ RFW WTI GY LTVVTVP LG  G LW A AL+IAERVGKAVR PAKDTLLS
Sbjct  69   GPLADRTGRFWTWTIGGYFLTVVTVPFLGAVGVLWAAAALIIAERVGKAVRSPAKDTLLS  128

Query  139  HAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLL  198
            HA +VTGRGRGFAVHEA+DQ+GA+ GPL VA ML + G  YAP L +L +PG   LALL 
Sbjct  129  HATAVTGRGRGFAVHEAMDQIGAVAGPLAVAAMLVVFGGDYAPTLALLAVPGVGVLALLA  188

Query  199  WLQRRVPRPESYEDCPVVLGNPSAPRPW--ALPAQFWLYCGFTAITMLGFGTFGLLSFHM  256
            WL+ RVP P  YE        P A   +  +LP  FW Y GF+A TMLGF TFG+LSFH 
Sbjct  189  WLRVRVPEPARYEVEAAPSTKPVARVSFLRSLPRSFWTYAGFSAATMLGFTTFGVLSFHQ  248

Query  257  VSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNV  316
            V  GV+  A+VPV+YAAAM ADAL ALA+G+ YD+ GA  L  LP+++ LV   AF D++
Sbjct  249  VERGVVHVAVVPVIYAAAMVADALAALATGWVYDKVGAVVLGALPVMAGLVPALAFNDHL  308

Query  317  TMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLY  376
              VV G LVWGAAVGIQESTLR VVADLV   RRA+AYG++AA LG A A GGAL G+LY
Sbjct  309  VPVVAGALVWGAAVGIQESTLRAVVADLVEPARRATAYGIYAAVLGCAAAAGGALTGYLY  368

Query  377  DISIGTLVVVVIALELMALVMMFAIR  402
              S+  LV VVI ++ +AL ++  +R
Sbjct  369  GQSVPLLVGVVIGVQAIALAVLPVVR  394


>gi|86741018|ref|YP_481418.1| major facilitator transporter [Frankia sp. CcI3]
 gi|86567880|gb|ABD11689.1| major facilitator superfamily MFS_1 [Frankia sp. CcI3]
Length=409

 Score =  352 bits (902),  Expect = 8e-95, Method: Compositional matrix adjust.
 Identities = 246/371 (67%), Positives = 277/371 (75%), Gaps = 6/371 (1%)

Query  19   LSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVS  78
            L  WRFV VFGVV +LADVVYEGARS+TGPLLASLGA+ +VVGVVTGVGEAAAL  RLV 
Sbjct  18   LRPWRFVLVFGVVSMLADVVYEGARSVTGPLLASLGASAVVVGVVTGVGEAAALLPRLVC  77

Query  79   GPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLS  138
            GPLA+R+ RFWAWTIAGYTLTV  VPLLG+ G LW A  LVIAERVGKAVR PAKD LLS
Sbjct  78   GPLAERTGRFWAWTIAGYTLTVAAVPLLGVTGVLWAAGLLVIAERVGKAVRSPAKDALLS  137

Query  139  HAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLL  198
            HA + TGRGRGFAVHEA+DQ+GA+ GPL VA +LA +G  Y PALGVL LPG   LA+LL
Sbjct  138  HATAATGRGRGFAVHEAMDQLGALAGPLLVAAVLA-SGAGYGPALGVLALPGLGVLAVLL  196

Query  199  WLQRRVPRPESYED-----CPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLS  253
            WL+ RVP P  YE       PV    P+A     LP  FW Y GFTA T  G  TFG+LS
Sbjct  197  WLRARVPDPAGYEPDEPPAVPVPRTGPAAAPRARLPRAFWTYAGFTAATTTGLATFGVLS  256

Query  254  FHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFT  313
            FH V+ G+L  A VPVVYAAAM  DAL ALA+G++YDR+G   LAVLP L+  V   AFT
Sbjct  257  FHAVTRGLLPVAAVPVVYAAAMGVDALAALATGWAYDRHGPGVLAVLPPLAAAVPALAFT  316

Query  314  DNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIG  373
            +   + V GTLVWGAA+G+QESTLR  VADLV   RRASAYGVFA  +GA TAGGGAL G
Sbjct  317  NTPALAVAGTLVWGAAIGVQESTLRATVADLVPPARRASAYGVFAGVVGATTAGGGALAG  376

Query  374  WLYDISIGTLV  384
             LYD+SI  L+
Sbjct  377  ALYDLSIPALI  387


>gi|336119617|ref|YP_004574394.1| putative major facilitator superfamily transporter [Microlunatus 
phosphovorus NM-1]
 gi|334687406|dbj|BAK36991.1| putative major facilitator superfamily transporter [Microlunatus 
phosphovorus NM-1]
Length=422

 Score =  306 bits (784),  Expect = 4e-81, Method: Compositional matrix adjust.
 Identities = 204/412 (50%), Positives = 270/412 (66%), Gaps = 24/412 (5%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +AW  V  FG+V L AD+VYEGAR+ITGPLLASLGAT  VVG+V+G+GEA +L LRLVSG
Sbjct  11   TAWSLVVGFGLVSLTADMVYEGARAITGPLLASLGATAAVVGLVSGLGEAVSLLLRLVSG  70

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGI-----AGALWVACALVIAERVGKAVRGPAKD  134
              ADRS R+W WTIAGY +T V+VP L I     A  L V C L+IAER GKAVR PAK 
Sbjct  71   SWADRSGRYWRWTIAGYAITAVSVPALAITPFLGAAGLVVGCLLIIAERFGKAVRSPAKS  130

Query  135  TLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAAL  194
             LL+ A+ V G GRGF VH+ALDQ+GA  GPL VA ++++TG  ++  L VL +PG  ++
Sbjct  131  VLLAQASGVVGLGRGFGVHKALDQLGAFAGPLLVAAVISLTGALWS-GLVVLAIPGALSI  189

Query  195  ALLLWLQRRVPRPESYED-----CPVVLGNPSA-PRPWA-----------LPAQFWLYCG  237
             +LL L+R      +  +      P V+ NPSA P P A           LP++FW +  
Sbjct  190  IVLLVLRRASNDTGTASNGPDSPTPGVVSNPSAMPIPSATPTAQPLPRHRLPSEFWTFAA  249

Query  238  FTAITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTL  297
                T  G  TF ++ +H+V   V +AA+VPV+YAAAMAA  + AL +GF +DR  A+ L
Sbjct  250  AAGATTAGLVTFAVIGYHLVDGRVTSAALVPVIYAAAMAAAGVAALGTGFLFDRIHARVL  309

Query  298  AVLPILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVF  357
             VLP+L   V +FAF D + +V++G L WGAA G+Q+ST++ +VADLV +PRR +AYG+F
Sbjct  310  LVLPLLVAAVPVFAFADALPLVMVGVLAWGAASGLQDSTVKALVADLVPAPRRGTAYGLF  369

Query  358  AAGLGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMF-AIRLPRVAP  408
            AA  G A   GG + G LYD S   L+  V A +L+ALV++   +R P V+P
Sbjct  370  AAVQGGAAVLGGVIAGALYDHSTPALIAYVAATQLIALVLLVRTLRRPPVSP  421


>gi|317126650|ref|YP_004100762.1| major facilitator superfamily MFS_1 [Intrasporangium calvum DSM 
43043]
 gi|315590738|gb|ADU50035.1| major facilitator superfamily MFS_1 [Intrasporangium calvum DSM 
43043]
Length=433

 Score =  283 bits (724),  Expect = 4e-74, Method: Compositional matrix adjust.
 Identities = 206/422 (49%), Positives = 270/422 (64%), Gaps = 29/422 (6%)

Query  15   TRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGL  74
            TRP +S+WR V  FGV+ L AD+VYEGARS+ GPLLASLGA+GLVVGVVTG+GEA AL L
Sbjct  5    TRP-MSSWRIVLWFGVISLTADMVYEGARSMYGPLLASLGASGLVVGVVTGLGEAMALVL  63

Query  75   RLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIA-----GALWVACALVIAERVGKAVR  129
            RLV GPLADR+ R+W  TI+GY LTVV VPLL +A       L VA  L++ ER GKA+R
Sbjct  64   RLVFGPLADRTGRYWLLTISGYALTVVCVPLLAVAPFLGGAGLAVAALLILLERSGKAIR  123

Query  130  GPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLP  189
             P+K  LL+HAA   GRGRGF V +A+DQVGA  GPL VA ++A TG  + P + VL +P
Sbjct  124  SPSKSALLAHAAGALGRGRGFGVQKAMDQVGAFAGPLVVAAVVAATGVIW-PGMLVLAVP  182

Query  190  GGAALALLLWLQRRVP------------RPESYEDC---PVVLGNPSAPRPW-------A  227
            G  A+A+LL L+ RVP             P + +D    P  +    A R W        
Sbjct  183  GVVAIAVLLVLRARVPDLGAVTGTPDAAHPPASDDPGSEPSGIRTRGAVRAWLADAVGSH  242

Query  228  LPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGF  287
            LP  F+ +    ++T  G  TFG++ +H+ +  V+  A VP+VYAAAMA  A++AL  G+
Sbjct  243  LPGDFFRFAVAASLTTGGLVTFGIIGYHLTADAVVPLATVPLVYAAAMAVGAVSALLVGW  302

Query  288  SYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVAS  347
             YDR GA  L V+P+L   V   A T +  +V+ G +VWG A+GIQ+S ++ +VA+LV +
Sbjct  303  VYDRAGAHVLLVVPVLVAAVPPLALTQSFGLVLAGVVVWGLALGIQDSAVKALVAELVPA  362

Query  348  PRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIRLPRVA  407
             RRA+AYGVFA   GA    GGA IGWLYD+S+  LVV V A +L+AL +++    P   
Sbjct  363  GRRATAYGVFAGIQGAFAVIGGAGIGWLYDVSLPALVVTVAATQLLALGLLWRTVRPGAG  422

Query  408  PS  409
            P 
Sbjct  423  PH  424


>gi|297618483|ref|YP_003703642.1| major facilitator superfamily protein [Syntrophothermus lipocalidus 
DSM 12680]
 gi|297146320|gb|ADI03077.1| major facilitator superfamily MFS_1 [Syntrophothermus lipocalidus 
DSM 12680]
Length=403

 Score =  279 bits (713),  Expect = 8e-73, Method: Compositional matrix adjust.
 Identities = 163/397 (42%), Positives = 230/397 (58%), Gaps = 7/397 (1%)

Query  6    DVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTG  65
            D A  +    R   SA +FV + G+V L AD+ YEGARSITG  LA LGA+  VVG+V G
Sbjct  9    DKAAQQAEGLRTKQSAIKFVVLIGLVSLFADMTYEGARSITGQYLAVLGASATVVGLVAG  68

Query  66   VGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVG  125
            VGE    GLRLVSG ++D++R++W  TI GY L +  VPLL + G   +A AL+I ER+G
Sbjct  69   VGEFIGYGLRLVSGYISDKTRQYWMLTIIGYMLNLFAVPLLALVGRWDLAAALMILERIG  128

Query  126  KAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGV  185
            KA+R PA+D +LSHA    G G GF +HEA+DQVGAM+GP+ VA +L + G  Y  + G+
Sbjct  129  KAIRTPARDAMLSHATRAVGSGWGFGLHEAMDQVGAMLGPVIVAAVLYLKGG-YETSFGI  187

Query  186  LTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLG  245
            L +P   A+ +LL  +   P P   E     +G P           FWLY G  A+   G
Sbjct  188  LVVPALLAITVLLTARYFYPNPRDLE-----VGYPKLNTK-GFAQVFWLYLGAVALIAFG  241

Query  246  FGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSI  305
            +  F L++FH     +     +P +YA AM  DAL ALA G  +DR G   LA+  +L+ 
Sbjct  242  YADFPLIAFHFKKVDIAPDQWLPTLYALAMGVDALAALAFGRLFDRIGIAALALGSLLTA  301

Query  306  LVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAAT  365
                  F   +   V G ++WG  +G QES +R  +A++V   +R +AYG+F  G G   
Sbjct  302  WFAPLVFYGGLPYAVAGMVLWGIGMGAQESIMRASIAEMVPIDKRGTAYGIFNTGYGVCW  361

Query  366  AGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIR  402
              G AL+G+LYD+S+  LVV  + ++L ++ +   +R
Sbjct  362  FLGSALMGYLYDVSLMFLVVFSVVVQLASIPLFLKVR  398


>gi|119487499|ref|ZP_01621109.1| hypothetical protein L8106_26622 [Lyngbya sp. PCC 8106]
 gi|119455668|gb|EAW36804.1| hypothetical protein L8106_26622 [Lyngbya sp. PCC 8106]
Length=393

 Score =  278 bits (712),  Expect = 9e-73, Method: Compositional matrix adjust.
 Identities = 156/379 (42%), Positives = 224/379 (60%), Gaps = 6/379 (1%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +A++FV + G+V L AD  YEGARSI G  L SLGA+G VVG+V G GE  A GLRL  G
Sbjct  8    AAFKFVVLLGIVSLCADATYEGARSINGQFLGSLGASGTVVGLVAGFGELIAYGLRLFIG  67

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+DR+R++W  T  GY +    VPLL +AG+L VA  L+IAER GKA+R P +D LLSH
Sbjct  68   FLSDRTRQYWRITTIGYAINTFAVPLLALAGSLPVAAGLMIAERTGKAIRTPPRDVLLSH  127

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A +  G G GF VHEALDQ+GA+ GPL VA +L++  N Y+     L +P    L +LL 
Sbjct  128  AVTQVGTGFGFGVHEALDQIGAVSGPLMVAAILSLQ-NDYSAGYAALMIPAVIGLIVLLT  186

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
            LQ+  P P  +E     L N    +    P  FWLY G   +   G+  F L+++H    
Sbjct  187  LQKVYPNPREFE-----LANRPILKAEKFPKAFWLYLGSVVLIAAGYADFPLIAYHFQQV  241

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
             +     +P++YA AM  DA+ A+  G  +DR G  +LA+   L+ +     F     + 
Sbjct  242  NLSDTNSIPLLYALAMGVDAIAAILFGRLFDRIGLLSLAIAAFLASVFAPLVFLGTPQLA  301

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            ++G ++WG  +G QES ++  +  +V++ +R SA+GVFA G G A   G  L+G LYD S
Sbjct  302  IVGMILWGIGMGAQESIMKAGITRIVSADQRGSAFGVFATGYGLAWFLGSVLMGILYDRS  361

Query  380  IGTLVVVVIALELMALVMM  398
            +  LV+  + ++L+A  ++
Sbjct  362  LLVLVIFSVVIQLLAFPLL  380


>gi|221632591|ref|YP_002521812.1| hypothetical protein trd_0566 [Thermomicrobium roseum DSM 5159]
 gi|221156891|gb|ACM06018.1| putative membrane protein [Thermomicrobium roseum DSM 5159]
Length=413

 Score =  277 bits (709),  Expect = 2e-72, Method: Compositional matrix adjust.
 Identities = 167/393 (43%), Positives = 236/393 (61%), Gaps = 6/393 (1%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            A+R + + G+V L  D+ YEG R +TGP LA LGA+ + VG+V G+GE A   LR  SG 
Sbjct  16   AYRLIILLGLVSLFGDISYEGVRGVTGPYLALLGASAVAVGLVAGLGEFAGYALRTASGY  75

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
            LADR R  W  T+ GY L + T+PLL +     +A AL++ ER+GKA+R P++D +LSHA
Sbjct  76   LADRLRLHWLLTVVGYGL-IATLPLLALVHRWELAAALIVLERLGKALRTPSRDAILSHA  134

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNA-YAPALGVLTLPGGAALALLLW  199
            AS  GRG+GF +HEALDQ+GA+IGP+  A  L   G A Y    G+LT+P   A+ +L+ 
Sbjct  135  ASQVGRGKGFGIHEALDQLGALIGPVIFAVALTFDGEAGYRLGFGLLTIPAILAIVILVL  194

Query  200  LQRRVPRPESYEDCPVVLGNPS-APRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVS  258
              R+ P PES E     +  P+ A     L   FW Y  FTA+T LGF  F LLS+H+  
Sbjct  195  AWRQEPEPESLESVTPRVNRPTEASGSRRLSGPFWRYTLFTALTTLGFVPFALLSYHVEQ  254

Query  259  HGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTM  318
             G  +  ++P++YA AM  D   AL +G+ YDR+G +TLA +PI   L    A       
Sbjct  255  TGRFSPPLIPLLYAVAMGVDGGIALIAGWGYDRFGLRTLAAVPICIALGTAAALQSTTGF  314

Query  319  VVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDI  378
            ++ G +VWG A+G+ E+T+R  V +L A   R  AYGVF    G A   GGA++G+LY+ 
Sbjct  315  IITGVVVWGIAMGLVETTMRAAVGELSAPSARGLAYGVFNTVFGTAWLAGGAVLGYLYEQ  374

Query  379  --SIGTLVVVVIALELMALVMMFAIRLPRVAPS  409
              S GT+   ++ LE+ AL++ + + + R   S
Sbjct  375  LGSRGTIGATLV-LEIAALLLFWGLGVARAHAS  406


>gi|333980028|ref|YP_004517973.1| major facilitator superfamily protein [Desulfotomaculum kuznetsovii 
DSM 6115]
 gi|333823509|gb|AEG16172.1| major facilitator superfamily MFS_1 [Desulfotomaculum kuznetsovii 
DSM 6115]
Length=383

 Score =  277 bits (708),  Expect = 3e-72, Method: Compositional matrix adjust.
 Identities = 164/378 (44%), Positives = 231/378 (62%), Gaps = 6/378 (1%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            A++F+ + G+V L +D+ YEGARSITGP LA LGATG +VG V G+GE    G+RL+SG 
Sbjct  5    AFKFIILLGIVSLFSDMTYEGARSITGPFLAMLGATGTIVGFVAGLGELLGYGVRLLSGY  64

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
            ++DR+ ++W  TI GY L ++ VP L +AG   VA  L+I ERVGKA+R PA+D +LS+A
Sbjct  65   ISDRTGKYWPITILGYFLNLLAVPFLALAGNWPVAAGLMITERVGKAIRTPARDAMLSYA  124

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWL  200
             S  GRGRGF +HEALDQ+GA+ GPL VA +L      Y     VL +P   AL +L+  
Sbjct  125  TSEVGRGRGFGLHEALDQIGAITGPLIVALVLYFLKGNYKAGFAVLLVPASVALIILIAA  184

Query  201  QRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHG  260
            +   P P   E  P++           LP++FWLY    A+   G+  + L++FH+    
Sbjct  185  RILYPVPRELEAAPIMAEGK------GLPSKFWLYLAAVALIAAGYVDYPLIAFHLGKTS  238

Query  261  VLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVV  320
            +++ A +P++YA AMAADAL AL  G+ +DR G   L +  ++S L     F  N   VV
Sbjct  239  LISPAWLPILYAIAMAADALAALIFGYLFDRTGINILVIAVLVSSLFAPLVFLGNFITVV  298

Query  321  IGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISI  380
             G  +WG  +G QES LR  +A ++   RR +AYGVF  G G     G AL+G LYD+S+
Sbjct  299  TGMAIWGIGMGAQESVLRAAIAGMIPPDRRGTAYGVFNTGYGLFWFLGSALMGILYDLSV  358

Query  381  GTLVVVVIALELMALVMM  398
            G +V   + ++L+A  MM
Sbjct  359  GYVVAFSVIVQLLAASMM  376


>gi|269926659|ref|YP_003323282.1| major facilitator superfamily MFS_1 [Thermobaculum terrenum ATCC 
BAA-798]
 gi|269790319|gb|ACZ42460.1| major facilitator superfamily MFS_1 [Thermobaculum terrenum ATCC 
BAA-798]
Length=399

 Score =  273 bits (698),  Expect = 4e-71, Method: Compositional matrix adjust.
 Identities = 161/397 (41%), Positives = 231/397 (59%), Gaps = 6/397 (1%)

Query  6    DVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTG  65
            D+   R   T     A+RF+ + G+V L AD+ YEGAR I GP LA LGA+G VVG V G
Sbjct  3    DIKTQRSTTTTIRSHAFRFIVLVGIVSLFADMTYEGARGIIGPYLAVLGASGAVVGFVAG  62

Query  66   VGEAAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVG  125
             GE      RLVSG ++DR+R++W  TI GY + +  VPLL + G   +A  LVIAER+G
Sbjct  63   FGELLGYAFRLVSGYISDRTRQYWLTTILGYVINLGAVPLLALTGNWQLAAILVIAERMG  122

Query  126  KAVRGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGV  185
            KA+R PA+D +LSHAAS  G G+GF +HEALDQ+GA++GPL VA  L  T  +Y     V
Sbjct  123  KALRVPARDAMLSHAASQIGTGKGFGIHEALDQIGAVVGPLIVAATLFFTSGSYRTGFAV  182

Query  186  LTLPGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLG  245
            L +P   ++A L+  +   P P   E   + L          L   FW+Y     +   G
Sbjct  183  LAIPAILSIATLIAARVMYPAPHKLEIRQIEL------ETQGLRGVFWVYMLAIGLIAAG  236

Query  246  FGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSI  305
            +  F L+++H     + +   +P++Y  AM  DAL AL  G  +DR G  +LA+  +LS 
Sbjct  237  YADFPLIAYHFQKANLFSQDAIPILYTVAMGTDALAALFLGALFDRMGMLSLAIGTVLSA  296

Query  306  LVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAAT  365
            L    +F  N  + VIG ++WG  +G QES +R  V+ +V + RR +A+GVF  G G   
Sbjct  297  LFAPLSFLGNAYLSVIGVIMWGIGMGAQESIMRAAVSRMVPADRRGAAFGVFNTGYGLFW  356

Query  366  AGGGALIGWLYDISIGTLVVVVIALELMALVMMFAIR  402
             GG  L+G LYDISI  LV+  + +++ ++V++ ++R
Sbjct  357  FGGSLLMGVLYDISIPLLVLFSVLVQVASVVIILSLR  393


>gi|338174078|ref|YP_004650888.1| protein Mb2288 [Parachlamydia acanthamoebae UV7]
 gi|336478436|emb|CCB85034.1| uncharacterized protein Mb2288 [Parachlamydia acanthamoebae UV7]
Length=387

 Score =  271 bits (694),  Expect = 1e-70, Method: Compositional matrix adjust.
 Identities = 159/386 (42%), Positives = 229/386 (60%), Gaps = 13/386 (3%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
             A  FV +FG + L AD+ YEGARSI+G  LA LGA+G VVG V G GE    G RLVSG
Sbjct  9    KAIHFVILFGFISLFADMTYEGARSISGQYLALLGASGAVVGTVAGAGELIGYGFRLVSG  68

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             ++DR+ R+W  T  GY L ++ VPL+ +AG   +A +L+I ER GKA+R PAKD LLS+
Sbjct  69   YISDRTGRYWTITFIGYFLNLLAVPLIALAGNWPLAASLMILERFGKAIRNPAKDALLSY  128

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A   TGRG GF +HEA+DQ+GA+ GPL V+G+L + G  Y  +  VL +P   AL++L+ 
Sbjct  129  ATKQTGRGWGFGLHEAMDQIGAITGPLIVSGVLYLQGT-YQASFAVLLIPALCALSVLVA  187

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
                 P PE  E+    L      +      ++WLY    +    G+  F L++FH    
Sbjct  188  TWFLYPNPEEMEEETPNLNTEGFTK------KYWLYIAAISCIAAGYVDFPLIAFHFEKA  241

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFA---FTDNV  316
             +L    +PV++A AMAAD ++AL  G+ YD+ G    +VL  +S +   FA   F   +
Sbjct  242  ALLPEVWIPVLFAIAMAADGISALICGYLYDKIG---FSVLIGVSFIAAFFAPCVFLGGL  298

Query  317  TMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLY  376
            + +V+G ++WG  +G QES +R V+A++V   +RA+AYG+     G A   G AL+G LY
Sbjct  299  SFIVLGAILWGIGLGAQESIVRAVIANMVRMNKRATAYGLMNIYFGIAWFLGSALMGLLY  358

Query  377  DISIGTLVVVVIALELMALVMMFAIR  402
            D S+  LV   +  +  AL + FA++
Sbjct  359  DRSLILLVAFSLIAQFAALPLFFAVK  384


>gi|163849334|ref|YP_001637378.1| major facilitator transporter [Chloroflexus aurantiacus J-10-fl]
 gi|222527328|ref|YP_002571799.1| major facilitator superfamily protein [Chloroflexus sp. Y-400-fl]
 gi|163670623|gb|ABY36989.1| major facilitator superfamily MFS_1 [Chloroflexus aurantiacus 
J-10-fl]
 gi|222451207|gb|ACM55473.1| major facilitator superfamily MFS_1 [Chloroflexus sp. Y-400-fl]
Length=389

 Score =  271 bits (694),  Expect = 1e-70, Method: Compositional matrix adjust.
 Identities = 163/381 (43%), Positives = 227/381 (60%), Gaps = 7/381 (1%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            A +F+T+ GVV LLAD+VYEG RS++G  LA LGA+G VVG+  G+GE    GLRLV G 
Sbjct  12   ALQFITLMGVVSLLADMVYEGGRSLSGQYLALLGASGAVVGLTAGIGELIGYGLRLVFGY  71

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
            L+DR+RR+W  TI GY+LTV+ VPLL +A A  +A  L++ ER+ KA+R PAKDTL+S+A
Sbjct  72   LSDRTRRYWLLTILGYSLTVIAVPLLALANAWPLAVGLLMVERLSKALRSPAKDTLISYA  131

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWL  200
            A   G G+GF +HE LDQ+GA++ PL +AG+LA +GN +  A GVL +PG   + +LL  
Sbjct  132  ADRVGAGKGFGLHEVLDQIGAVLAPLLLAGILAFSGN-FQLAFGVLIIPGLLCMMVLLMA  190

Query  201  QRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHG  260
            + R P+P         +      R      QFW Y    A+       F L ++H+    
Sbjct  191  RMRFPQPADLARQTPAITTTGFSR------QFWYYLAGVALFAAASVDFALAAYHLQRLQ  244

Query  261  VLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVV  320
            ++  A +P +YA AM  DA+ A   G  YDR G   L  +  L  L     F+  +  V+
Sbjct  245  IVQPAGIPALYALAMTVDAVAAFGFGLLYDRIGLGALVGVTALGALSTPLLFSTGLLTVI  304

Query  321  IGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISI  380
            IG ++WGA +G QES LR  V  L    RR +AYG+F AG G +   G A +G LYD ++
Sbjct  305  IGVVLWGAVLGAQESILRAAVGQLAPPDRRGAAYGLFHAGFGVSWFVGSACLGLLYDRAL  364

Query  381  GTLVVVVIALELMALVMMFAI  401
              L+ V  AL L A +++F +
Sbjct  365  PALIGVSAALYLGAALVLFYV  385


>gi|339500890|ref|YP_004698925.1| major facilitator superfamily protein [Spirochaeta caldaria DSM 
7334]
 gi|338835239|gb|AEJ20417.1| major facilitator superfamily MFS_1 [Spirochaeta caldaria DSM 
7334]
Length=402

 Score =  269 bits (687),  Expect = 6e-70, Method: Compositional matrix adjust.
 Identities = 145/380 (39%), Positives = 218/380 (58%), Gaps = 6/380 (1%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +A+ F+ +FGVV L +D+ +EGARSITGP L+SLG +   V  + G GE     LR  SG
Sbjct  18   AAYLFIVLFGVVSLFSDMTHEGARSITGPFLSSLGLSAAAVATIAGFGEFVGYALRFASG  77

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+D+++R+W  T  GYT+ +++VPLL +AG+  +A  L+I ER G+A+R PA+D +LSH
Sbjct  78   YLSDKTKRYWLVTGVGYTVNLLSVPLLALAGSWQIAALLMILERAGRAIRNPARDGMLSH  137

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A S TG G+GF +HEALDQ+GA  GPL +  +LA  G     A   L +P   AL +L+ 
Sbjct  138  ATSETGHGKGFGLHEALDQIGATTGPLIITVVLA-AGGTMQHAFSFLLIPALTALIILMA  196

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
             + R P P++ E            R    P  FW Y    ++  +GF  + LL++H    
Sbjct  197  TRIRYPHPQALETA-----QKENLRGAHFPKAFWFYLIAASLVAVGFVDYTLLAYHFQKG  251

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
             ++  + + + Y  AM  DA+ AL  G  YD+ G + L +   LS+   +F F  N T+ 
Sbjct  252  DLMKPSTIAIYYGIAMGTDAVFALIFGSLYDKIGIRALVISTALSLFFPVFGFQHNGTLA  311

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            +IG ++WG  +G QES +R  +A   +  +RA+AYG F    G +   G AL G LYDIS
Sbjct  312  LIGVMLWGVGMGAQESIMRAAIAHFASKDKRATAYGFFNMVYGFSWFAGSALFGVLYDIS  371

Query  380  IGTLVVVVIALELMALVMMF  399
            I   +V  + ++ +++   F
Sbjct  372  IPWAIVFSVVMQAISIPFFF  391


>gi|154248866|ref|YP_001409691.1| major facilitator transporter [Fervidobacterium nodosum Rt17-B1]
 gi|154152802|gb|ABS60034.1| major facilitator superfamily MFS_1 [Fervidobacterium nodosum 
Rt17-B1]
Length=393

 Score =  269 bits (687),  Expect = 7e-70, Method: Compositional matrix adjust.
 Identities = 149/394 (38%), Positives = 221/394 (57%), Gaps = 11/394 (2%)

Query  14   ATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALG  73
            A      A  F+ + G V L +D+ YEGARS+ GP L  LGA+ +VV  + G+GE     
Sbjct  4    AKNMKKKALYFIVLMGFVSLFSDITYEGARSLVGPYLGLLGASAVVVSAIAGLGELLGYT  63

Query  74   LRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAK  133
            LR V+G L D+++++W + I GY++ ++ +P L +     +A  LVI ERVGKA+R PAK
Sbjct  64   LRFVTGKLVDKTKKYWFFAILGYSINLLVIPTLALTKHWILAAILVILERVGKALRKPAK  123

Query  134  DTLLSHAASVTGRGRGFAVHEALDQVGAMIGP----LTVAGMLAI-TGNAYAPALGVLTL  188
            DT+ S A+S  G G GFA+ E +DQ+GA IGP    LT+A  + + T +AY  A   L  
Sbjct  124  DTITSFASSQVGYGTGFAIEEFMDQIGATIGPLFMSLTIANNIKLETVDAYRKAFAFLVF  183

Query  189  PGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGT  248
            P    + ++   +  VP PE  E     + +    R       F+LY    ++   GF  
Sbjct  184  PAVITIGIIFIARVLVPNPEKMEKAKETIKDVKLDRT------FYLYLAGISLIAFGFAD  237

Query  249  FGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVV  308
            F L+ FH     +L+ AM+P+ Y  AM  DA  AL  G  +DR G   LA+   +S    
Sbjct  238  FALIGFHAQKLNLLSPAMIPIAYMIAMIVDAFAALFFGKLFDRLGIGVLAISTFISAFYG  297

Query  309  LFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGG  368
            +F+F ++ T +++G+++WG  +G QES ++  VA LV   +RA+AYG F A  G A   G
Sbjct  298  IFSFGNSGTFIMVGSILWGIGMGAQESIMKAAVAKLVEKEKRATAYGFFNAVFGIAWFVG  357

Query  369  GALIGWLYDISIGTLVVVVIALELMALVMMFAIR  402
             AL+G LY ISI +L+ V I  E+ A+++   IR
Sbjct  358  SALLGILYSISIKSLIAVSIISEIAAVIIFLTIR  391


>gi|75906469|ref|YP_320765.1| major facilitator transporter [Anabaena variabilis ATCC 29413]
 gi|15559069|gb|AAL02109.1|AF408411_4 unknown [Anabaena variabilis ATCC 29413]
 gi|75700194|gb|ABA19870.1| Major facilitator superfamily MFS_1 [Anabaena variabilis ATCC 
29413]
Length=397

 Score =  268 bits (685),  Expect = 1e-69, Method: Compositional matrix adjust.
 Identities = 163/385 (43%), Positives = 218/385 (57%), Gaps = 6/385 (1%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +A RFV + G V L AD  YEGARSITG  L  LGA+G VVG+V G GE    GLRLV G
Sbjct  6    AALRFVILLGFVSLCADATYEGARSITGAYLQVLGASGTVVGLVAGFGELIGYGLRLVIG  65

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+D+SR++W  T  GY L    VPLL + G    A  L++AER GKAVR P +D LLSH
Sbjct  66   YLSDQSRKYWGITTLGYILNTAVVPLLALTGRWEAAAGLMMAERTGKAVRTPPRDALLSH  125

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
             AS  GRG GF +HEA+DQ GA++GPL VA M+   G  Y  A  +L +P    L +LL 
Sbjct  126  GASQIGRGFGFGLHEAMDQTGAVMGPLAVAAMVYFQGE-YRHAFTILIVPAVLGLVVLLV  184

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
            LQ   P P  +E+               LP  FW+Y G  A+   G+  F L++FH    
Sbjct  185  LQFLYPNPSDFEEETEEQKQQE-----GLPRIFWIYLGAVAVIAAGYADFPLIAFHFQKS  239

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
            G+     +P+ YA AM  DA+ AL  G+ +DR G   L +   +S L     F  +  + 
Sbjct  240  GIATGETIPLFYALAMGVDAIAALIFGYVFDRLGISILIIAAFISCLFAPLVFLGDTNLA  299

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            ++G   WG  +G QES L+  +A +V   +RA+AYG+F+ G G +   G AL+G LYD S
Sbjct  300  LLGIAFWGIGMGAQESILKAAIAGMVPKHKRATAYGIFSTGYGLSWFLGSALMGILYDHS  359

Query  380  IGTLVVVVIALELMALVMMFAIRLP  404
            I TL+V   A +L+A+     ++L 
Sbjct  360  ITTLIVFSSATQLLAIPFFTWVKLK  384


>gi|119715785|ref|YP_922750.1| major facilitator transporter [Nocardioides sp. JS614]
 gi|119536446|gb|ABL81063.1| major facilitator superfamily MFS_1 [Nocardioides sp. JS614]
Length=423

 Score =  266 bits (679),  Expect = 6e-69, Method: Compositional matrix adjust.
 Identities = 175/363 (49%), Positives = 228/363 (63%), Gaps = 31/363 (8%)

Query  18   ALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLV  77
            A S WR V  FG+V L AD+VYEG R+  GP L +LGA+ L VG+VTG GE  AL LRLV
Sbjct  17   AWSPWRTVLAFGLVSLAADMVYEGMRATAGPFLGTLGASALTVGLVTGAGEGIALVLRLV  76

Query  78   SGPLADRSRRFWAWTIAGYTLTVVTVPLL------GIAGALWVACALVIAERVGKAVRGP  131
            +G  ADRS   W  T+ GY +T V VPLL      G+AG L VA  L++ ER GKAVR P
Sbjct  77   TGVWADRSHHHWRLTVLGYAMTAVCVPLLAITPFIGVAG-LAVAATLILLERTGKAVRSP  135

Query  132  AKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGG  191
            AK  LL+  A+ TGRG+GFAVH+ALDQ+GA  GPL +AG+ A TG  + P   +L +PG 
Sbjct  136  AKSALLARMATATGRGKGFAVHKALDQIGAFSGPLLLAGVAAATGVLW-PGFAILAIPGA  194

Query  192  AALALLLWLQRRVP---RPESYEDCPV------------VLGNPSAPRPWALPAQFWLYC  236
             +L LL  L+ R P    PE  +D P+            V+G+        LP  F L+ 
Sbjct  195  LSLVLLAQLRLRAPIVTEPER-DDAPLPATSALVAVGKAVVGSD-------LPRAFHLFA  246

Query  237  GFTAITMLGFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKT  296
              TA+   G  TFG++SF +V  G+LAAA VP+ YA AMA +A+ AL +G  +DR G + 
Sbjct  247  LATAMMTAGLMTFGVISFRLVQDGLLAAAAVPLAYALAMAVEAIAALGTGHLFDRRGGRV  306

Query  297  LAVLPILSILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGV  356
            L  +P+L  +V L  F   + +V++G +VWG A GIQ+ST++  VADLV +PRRA+AYGV
Sbjct  307  LLAVPVLVAIVPLCVFATQLWLVLVGIVVWGVATGIQDSTVKAYVADLVPAPRRATAYGV  366

Query  357  FAA  359
            FAA
Sbjct  367  FAA  369


>gi|17229926|ref|NP_486474.1| hypothetical protein alr2434 [Nostoc sp. PCC 7120]
 gi|17131526|dbj|BAB74133.1| alr2434 [Nostoc sp. PCC 7120]
Length=397

 Score =  265 bits (677),  Expect = 1e-68, Method: Compositional matrix adjust.
 Identities = 161/385 (42%), Positives = 216/385 (57%), Gaps = 6/385 (1%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +A +FV + G V L AD  YEGARSITG  L  LGA+G VVG+V G GE    GLRLV G
Sbjct  6    AALKFVILLGFVSLCADATYEGARSITGAYLQVLGASGTVVGLVAGFGELIGYGLRLVIG  65

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+D+SR++W  T  GY L    VPLL   G    A  L++AER GKAVR P +D LLSH
Sbjct  66   YLSDQSRKYWGITTLGYILNTAVVPLLAFTGRWEAAAGLMMAERTGKAVRTPPRDALLSH  125

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
              S  GRG GF +HEA+DQ GA++GPL VA M+   G  Y  A  +L +P    L +LL 
Sbjct  126  GVSQIGRGFGFGLHEAMDQTGAVMGPLAVAAMVYFQGE-YRHAFTILIVPAVLGLVVLLV  184

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
            LQ   P P  +E+               LP  FW+Y G  A+   G+  F L++FH    
Sbjct  185  LQFLYPNPSDFEEETEEQKQQE-----GLPRIFWIYLGAVAVIAAGYADFPLIAFHFQKS  239

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
            G+     +P+ YA AM  DA+ AL  G+ +DR G   L +   +S L     F  +  + 
Sbjct  240  GIATGETIPLFYALAMGVDAIAALIFGYVFDRLGISILIIAAFISCLFAPLVFLGDTNLA  299

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            ++G   WG  +G QES L+  +A +V   +RA+AYG+F+ G G +   G AL+G LYD S
Sbjct  300  LLGIAFWGIGMGAQESILKAAIAGMVPKHKRATAYGIFSTGYGLSWFLGSALMGILYDHS  359

Query  380  IGTLVVVVIALELMALVMMFAIRLP  404
            I TL+V   A +L+A+     ++L 
Sbjct  360  ITTLIVFSSATQLLAIPFFVWVKLK  384


>gi|11499136|ref|NP_070370.1| hypothetical protein AF1541 [Archaeoglobus fulgidus DSM 4304]
 gi|2649020|gb|AAB89705.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304]
Length=372

 Score =  264 bits (674),  Expect = 3e-68, Method: Compositional matrix adjust.
 Identities = 157/375 (42%), Positives = 223/375 (60%), Gaps = 15/375 (4%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            A +F+ + G+V L  D+ YEGARSI GP LA+ G T   +G++TG GE A  GLRL+SG 
Sbjct  4    AMKFILLMGLVSLFGDITYEGARSIVGPYLATFGLTAAAIGLITGFGEFAGYGLRLLSGY  63

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
            +ADR+  +W  T  GY+L ++ +PLL  A   W+A  L++AER+GKA+R PA+D +LS A
Sbjct  64   IADRTGNYWLLTFLGYSL-ILAIPLLAFANYWWIAALLIVAERLGKAIRTPARDAMLSFA  122

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWL  200
                GRG GF +HEA+DQVGA+IGPL V   LA  G  +  A   L LP    +  L   
Sbjct  123  TKQVGRGTGFGIHEAMDQVGAVIGPLIVFSALA--GYTFKEAFIALFLPALLVILFLFAT  180

Query  201  QRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHG  260
             +  P P+ +E            +   +   FWLY  F  +++ GF +F LLS+H+   G
Sbjct  181  WKLYPTPQRFE---------IEEQESRVEGSFWLYSLFVFLSVAGFLSFPLLSYHLA--G  229

Query  261  VLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVV  320
             +   ++P++YA AM  DA++AL SG  YDR G KTL +L  L   ++L A   ++  V+
Sbjct  230  YVDLKLIPLLYALAMGIDAISALISGRCYDRIGLKTL-MLVPLLTPLILLALHPSIIGVL  288

Query  321  IGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISI  380
            +G   WGA +G+ E+  R  VADL    +R++AYGVF    G A   GGA++G+LYDIS 
Sbjct  289  VGVAAWGAVMGMHEAITRAAVADLTGVKKRSTAYGVFNTVFGVAMLAGGAVLGYLYDISA  348

Query  381  GTLVVVVIALELMAL  395
              LV  V+ +E+ A 
Sbjct  349  ALLVGFVLVVEVAAF  363


>gi|218437727|ref|YP_002376056.1| major facilitator superfamily protein [Cyanothece sp. PCC 7424]
 gi|218170455|gb|ACK69188.1| major facilitator superfamily MFS_1 [Cyanothece sp. PCC 7424]
Length=398

 Score =  262 bits (669),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 157/382 (42%), Positives = 214/382 (57%), Gaps = 5/382 (1%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            SA +F+ V G V L AD  YEGARSITG  L  LGA+G VVG+V G+GE    GLRLV G
Sbjct  11   SALKFIFVLGFVSLCADATYEGARSITGAYLGFLGASGTVVGLVAGLGELIGYGLRLVIG  70

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             ++DR++++W  T  GY L    VPLL  AG   VA  L+I+ERVGKA+R P +D LLSH
Sbjct  71   YMSDRTQKYWLITTLGYFLNTAVVPLLAFAGRWEVAAGLMISERVGKAIRTPPRDVLLSH  130

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            AA   G+G GF +HEA+DQ GA+IGPL VA ML      Y     +L +P    L ++L 
Sbjct  131  AAIKVGKGFGFGLHEAMDQTGAVIGPLAVAAMLYWQ-QGYQGGFKILAIPAILGLIVVLI  189

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
             Q   P P  +ED  V +          LP  FW+Y    A+   GF  F L++ H    
Sbjct  190  AQVLYPNPREFEDETVAIKQEGE----GLPKIFWIYLAAVALIAAGFADFPLIALHFQQE  245

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
              +    + ++YA AM  DA+ AL  G  +D  G   L V  ++S       F  N  ++
Sbjct  246  IHIDPNAIALLYALAMGVDAVAALIFGRLFDWIGINVLMVAALISAGFAPAIFLGNSNLI  305

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            ++G + W   +G QES L+ VVA LV   RR SAYG+F  G G A   G A++G LYD++
Sbjct  306  LLGMIFWAIGMGAQESVLKAVVAGLVPIERRGSAYGIFNTGYGLAWFAGSAIMGILYDVN  365

Query  380  IGTLVVVVIALELMALVMMFAI  401
            +  LV   +  +L ++ ++F +
Sbjct  366  MAWLVGFSVFFQLASIPVLFIV  387


>gi|328954411|ref|YP_004371745.1| major facilitator superfamily MFS_1 [Desulfobacca acetoxidans 
DSM 11109]
 gi|328454735|gb|AEB10564.1| major facilitator superfamily MFS_1 [Desulfobacca acetoxidans 
DSM 11109]
Length=403

 Score =  261 bits (668),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 159/382 (42%), Positives = 221/382 (58%), Gaps = 9/382 (2%)

Query  15   TRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGL  74
            T+P  SA +FV + GVV LL+D+ YEGARSI GP LA LGA   VV  V G+GE     L
Sbjct  15   TQP--SALKFVILLGVVSLLSDMTYEGARSINGPFLALLGAGATVVATVAGLGELIGYAL  72

Query  75   RLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKD  134
            RL+SG L D+++R+W  T+ GY L +  VPLL +AG   +A AL++ ER+GKA+R PA+D
Sbjct  73   RLLSGYLTDQTKRYWTITLVGYALNLFAVPLLALAGRWEIAAALMLTERLGKAIRNPARD  132

Query  135  TLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAIT-GNAYAPALGVLTLPGGAA  193
             +LSHAAS  GRG GF +HEA+DQ+GA+ GPL VA +L       YA    +L +P   A
Sbjct  133  AMLSHAASTMGRGWGFGLHEAMDQLGAIFGPLIVAIVLFFQVKGGYASGYAILLIPAILA  192

Query  194  LALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLS  253
            L +LL  +   P+P   E   + + +    RP      FWLY    A+   G+  F L++
Sbjct  193  LLVLLTGRYLYPQPHQLEVKVLKVESTGLSRP------FWLYIAAVALIGAGYADFPLVA  246

Query  254  FHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFT  313
            +H     V+    +P+ YA AM  DA+ AL  G+ YD  G   +    +LS       F 
Sbjct  247  YHFKKEAVMTDTWIPLAYAVAMGTDAVAALILGYIYDHLGIMVMVGATLLSAFFAPLVFL  306

Query  314  DNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIG  373
                  + G ++WG  +G QES +R  +AD+V SPRRASAYG+F  G G     G  L+G
Sbjct  307  GGFFGAMTGMVLWGIGMGAQESVMRAAIADMVPSPRRASAYGIFQTGYGLFWFLGSLLMG  366

Query  374  WLYDISIGTLVVVVIALELMAL  395
             LY+  +  L++  +A +L+AL
Sbjct  367  LLYNNFLIYLIIFSVASQLLAL  388


>gi|219850575|ref|YP_002465008.1| major facilitator superfamily protein [Chloroflexus aggregans 
DSM 9485]
 gi|219544834|gb|ACL26572.1| major facilitator superfamily MFS_1 [Chloroflexus aggregans DSM 
9485]
Length=389

 Score =  261 bits (667),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 162/385 (43%), Positives = 233/385 (61%), Gaps = 11/385 (2%)

Query  23   RFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLA  82
            +F+ + GVV LLAD+VYEG RS++G  LA LGA+G+VVG+  G GE    GLRLV G L+
Sbjct  13   QFIVLMGVVSLLADMVYEGGRSLSGQYLALLGASGMVVGLTAGAGELIGYGLRLVFGYLS  72

Query  83   DRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAAS  142
            DR+RR+W  TI GYTLT++ VP+L +A    +A  L++ ER  KA+R PAKDTLLS+AA 
Sbjct  73   DRTRRYWLLTILGYTLTIIAVPMLALAQTWPLAVGLLMVERFSKALRSPAKDTLLSYAAE  132

Query  143  VTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQR  202
              G G+GF +HEALDQ+GA+  PL +A +LA++G+ +  A  +L +PG A L +L+  + 
Sbjct  133  RVGTGKGFGLHEALDQIGAVAAPLGLAAVLAVSGS-FQMAFTLLIVPGVACLIVLIVARI  191

Query  203  RVPRPESY-EDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGV  261
              P+P       P +L          L A+FW Y     +       F L ++H     +
Sbjct  192  LFPQPSDLVSKTPELLTT-------GLQARFWWYLLSVGLFAAASVDFALAAYHFQRTQL  244

Query  262  LAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVI  321
            ++AA +PV+YA AM  DA+ AL  GF YDR G   L+ + + + L     F+D +   V+
Sbjct  245  ISAAAIPVLYALAMVVDAVAALGFGFLYDRIGMPVLSGITLFAALSTPLLFSDVLVAAVL  304

Query  322  GTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIG  381
            G ++WG  +G QES LR  V     + RR +AYG+F A  G +   G AL G LYD+++ 
Sbjct  305  GVVIWGITLGAQESILRAAVTRFTPADRRGAAYGLFNACFGLSWFIGSALFGVLYDVALP  364

Query  382  TLVVVVIALELM-ALVMMFAI-RLP  404
             L+ V ++L LM AL++ F + R P
Sbjct  365  VLIGVSVSLYLMAALILWFVVTRQP  389


>gi|307153821|ref|YP_003889205.1| major facilitator superfamily protein [Cyanothece sp. PCC 7822]
 gi|306984049|gb|ADN15930.1| major facilitator superfamily MFS_1 [Cyanothece sp. PCC 7822]
Length=394

 Score =  259 bits (663),  Expect = 4e-67, Method: Compositional matrix adjust.
 Identities = 159/384 (42%), Positives = 214/384 (56%), Gaps = 7/384 (1%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            SA +F+ + G V L AD  YEGARSITG  L  LGA+G VVG+V G+GE    GLRLV G
Sbjct  11   SALKFIFILGFVSLCADATYEGARSITGAYLGFLGASGTVVGLVAGLGELIGYGLRLVIG  70

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             ++DR++++W  T  GY +    VPLL  AG    A AL+IAERVGKA+R P +D LLSH
Sbjct  71   YMSDRTQKYWLITTLGYFINTGVVPLLAFAGRWETAAALMIAERVGKAIRTPPRDVLLSH  130

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            AA   G+G GF +HEA+DQ GA+IGPL VAGM+A  G  Y     +L +P    L ++L 
Sbjct  131  AAINVGKGFGFGLHEAMDQTGAVIGPLAVAGMIA-WGKGYQGGFAILVIPAVLGLIVVLV  189

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
             Q   P P  +E+  V       PR       FW+Y G  A+   GF  F LL+ H    
Sbjct  190  AQLLYPNPREFEEETVKQEGEGLPRV------FWIYLGAVALIAAGFADFPLLALHFQQQ  243

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
              L  + + ++YA AM  DA+ AL  G  +D  G   L +   +S       F  N    
Sbjct  244  IHLTPSTIALLYAFAMGVDAVAALIFGRLFDWVGVNVLMLAAFISSGFAPVIFLGNPNWA  303

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            + G ++W   +G QES L+ VVA LV   RR SAYG+F  G G A   G A++G LYD++
Sbjct  304  IWGMVLWAIGMGAQESVLKAVVAGLVPIERRGSAYGIFNTGYGLAWFAGSAIMGILYDVN  363

Query  380  IGTLVVVVIALELMALVMMFAIRL  403
               LV   +  +L ++ ++  + L
Sbjct  364  SLWLVAFSVVFQLASIPVLLVVSL  387


>gi|345302473|ref|YP_004824375.1| major facilitator superfamily protein [Rhodothermus marinus SG0.5JP17-172]
 gi|345111706|gb|AEN72538.1| major facilitator superfamily MFS_1 [Rhodothermus marinus SG0.5JP17-172]
Length=393

 Score =  259 bits (662),  Expect = 6e-67, Method: Compositional matrix adjust.
 Identities = 173/398 (44%), Positives = 231/398 (59%), Gaps = 7/398 (1%)

Query  9    LSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGE  68
            ++R  AT     A   + +FG+V LLAD+ YE ARS+ GP L  LGA+   VGVV G GE
Sbjct  1    MTRPAATPTTRRALWLIVLFGLVSLLADLTYESARSLIGPYLGWLGASATAVGVVAGAGE  60

Query  69   AAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAV  128
                GLRL SG L+DR+RR+W  T+ GY + ++ VP L +AG   VA AL+IAER GKA+
Sbjct  61   LVGYGLRLASGYLSDRTRRYWTLTLLGYAVNLLAVPALALAGRWEVAAALIIAERAGKAL  120

Query  129  RGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTL  188
            R PA+D LLSHA +  G GRGF +HEALDQ+GA+ GPL +AG+L + G  Y  A  +L +
Sbjct  121  RTPARDVLLSHATAQVGHGRGFGLHEALDQIGAVAGPLLMAGVL-LQGGDYRTAFALLLV  179

Query  189  PGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGT  248
            P   AL LL   + R PRP+  E        P+AP     P  FW+Y     +   G+  
Sbjct  180  PALLALGLLGVARLRYPRPQELEAA-----RPTAPADRTFPRTFWIYLTGAGLLAAGYAD  234

Query  249  FGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVV  308
            F L+++H    GVL  A +P+ YA AM  DA  AL  G  +DR+G  TLA+   L+    
Sbjct  235  FPLIAYHFREAGVLPEAWIPLSYALAMGVDAGAALLLGRWFDRFGPITLALAVALTSAFA  294

Query  309  LFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGG  368
               F        +G  +WG  +G QES LR  +A ++A  RR +A+G+F A  G     G
Sbjct  295  PLTFLGGAAAAWVGMALWGVGMGAQESILRATLARMIAPERRGTAFGLFHAVFGVCWFAG  354

Query  369  GALIGWLYDISIGTLVVVVIALE-LMALVMMFAIRLPR  405
             AL+G LYD SI  LV V +AL+ L ALV+ +  R P+
Sbjct  355  SALLGVLYDTSIPALVGVAVALQVLAALVLGWMSRQPK  392


>gi|145594879|ref|YP_001159176.1| major facilitator transporter [Salinispora tropica CNB-440]
 gi|145304216|gb|ABP54798.1| major facilitator superfamily MFS_1 [Salinispora tropica CNB-440]
Length=420

 Score =  259 bits (661),  Expect = 8e-67, Method: Compositional matrix adjust.
 Identities = 194/375 (52%), Positives = 238/375 (64%), Gaps = 18/375 (4%)

Query  17   PALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRL  76
            P+ S WR V  FGVV L AD+VYEGARS+ GPLLASLGA+ L+VG++TG GEAAAL LRL
Sbjct  23   PSWSPWRTVIGFGVVSLAADMVYEGARSVYGPLLASLGASALIVGLITGAGEAAALALRL  82

Query  77   VSGPLADRSRRFWAWTIAGYTLTVVTVPLLGI-----AGALWVACALVIAERVGKAVRGP  131
            VSGPLADR+RR+W  T  GY LT V VPLL +     A  L VA  L++AER+GKAVR P
Sbjct  83   VSGPLADRTRRYWTLTTLGYALTAVCVPLLAVTPRLGAAGLVVAAVLIVAERLGKAVRSP  142

Query  132  AKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGG  191
            AK  LL+ AA   G GRG  VH+ALDQVGA  GPL +A + A  G    P L  L +PG 
Sbjct  143  AKSVLLADAAGAVGMGRGMGVHKALDQVGAFAGPLLLAALTAAAGGLLWPGLAGLAVPGA  202

Query  192  AALALLLWLQRRV----PRP---ESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITML  244
             A+ LL+ L+RR     PR    ++ E+     G  S      LPA F  +    A+   
Sbjct  203  LAMVLLVVLRRRAGIAHPRDVAADNREEYVDPAGRAS------LPASFGWFAVACALCTA  256

Query  245  GFGTFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILS  304
            G  TFGL+ FH+   G++ AA VP++YAAAMAA A+ ALA+G +YD  GA+ L VLPIL 
Sbjct  257  GLMTFGLIGFHLAQTGLVPAAGVPLLYAAAMAAAAVAALATGAAYDHIGARVLLVLPILV  316

Query  305  ILVVLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAA  364
             +V   AFT  + M   G L WGAA+G+Q+ST++  VADLV   RR +AYGVFAA   A 
Sbjct  317  AVVPPLAFTTGLAMAAGGVLAWGAALGVQDSTVKAFVADLVPRSRRGTAYGVFAAVQAAG  376

Query  365  TAGGGALIGWLYDIS  379
               GG   G LYD S
Sbjct  377  ALVGGVAAGALYDSS  391


>gi|126178383|ref|YP_001046348.1| major facilitator transporter [Methanoculleus marisnigri JR1]
 gi|125861177|gb|ABN56366.1| major facilitator superfamily MFS_1 [Methanoculleus marisnigri 
JR1]
Length=389

 Score =  258 bits (659),  Expect = 1e-66, Method: Compositional matrix adjust.
 Identities = 157/390 (41%), Positives = 227/390 (59%), Gaps = 8/390 (2%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +A+  + +FG+V L  D++YEGARS++GP L  LGA+ L VGVV G+GE     LRL SG
Sbjct  7    AAYTVIVLFGIVSLFGDIIYEGARSVSGPYLYILGASALAVGVVAGLGEFLGYALRLASG  66

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             LAD +R +WA T  GY +      L  +AG+   A  L+I ER GK +R PA+D +L++
Sbjct  67   YLADTTRHYWAITFIGYGMLAAVPLLA-LAGSWEAAALLLILERAGKGIRVPARDAILAN  125

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A +  GRG GFAVHEALDQVGA+IGPL    +    G+ Y     +L +P    +  LL+
Sbjct  126  ATTTVGRGWGFAVHEALDQVGAVIGPLIFTAIFLAQGD-YRSGFALLAVPFVLMILALLF  184

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
             +RR P P S E         S  R  +LP     Y  FTA+TM GF  F ++++H    
Sbjct  185  ARRRAPEPVSLE------AGGSDSRGTSLPGPLLPYGVFTALTMAGFAAFPIIAYHFAVT  238

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
            G ++ A +P+ YA AM  DA+ AL  G +YDR+G  TL  +P+L+I +   AF  +  + 
Sbjct  239  GTVSEAEIPLFYAVAMGVDAIAALTIGRAYDRFGLVTLLSVPLLAIGIPFLAFGTSYALA  298

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            +   ++WGAA+G QE+ LR  VAD     +R +AYG+F    GAA   G A+IGW Y ++
Sbjct  299  LAAVVLWGAAMGAQETILRAAVADYTHISKRGTAYGIFNTVYGAAWFAGSAVIGWAYTVA  358

Query  380  IGTLVVVVIALELMALVMMFAIRLPRVAPS  409
            +  +V  ++ +++ AL     +R    AP+
Sbjct  359  VPLVVGFLVVMQIGALAAFAWMRRGSAAPA  388


>gi|206890274|ref|YP_002249597.1| hypothetical protein THEYE_A1806 [Thermodesulfovibrio yellowstonii 
DSM 11347]
 gi|206742212|gb|ACI21269.1| conserved protein [Thermodesulfovibrio yellowstonii DSM 11347]
Length=382

 Score =  258 bits (658),  Expect = 2e-66, Method: Compositional matrix adjust.
 Identities = 147/379 (39%), Positives = 213/379 (57%), Gaps = 7/379 (1%)

Query  24   FVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLAD  83
            F+ + G V L +D+ YE ARSITGP L  LGA+  +VG++ G+GE     LRL+SG +AD
Sbjct  7    FIVLLGFVSLFSDMTYEAARSITGPYLEVLGASAALVGLIAGLGEFLGYALRLISGWIAD  66

Query  84   RSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASV  143
            ++ ++W+ TI GY + +++VP L + G   +A  L++AER+GKA+R P++D +LSHA   
Sbjct  67   KTGKYWSITIIGYIINLLSVPALALVGQWQLAALLIMAERIGKAIRNPSRDAMLSHATVE  126

Query  144  TGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRR  203
             GRG GF +HEA+DQ+GAMIGPL VAG+    G  Y  A GVL +P   A+ +LL+ +  
Sbjct  127  IGRGWGFGLHEAMDQIGAMIGPLIVAGVFYFHGG-YREAFGVLLIPAAIAILILLFARIL  185

Query  204  VPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLA  263
             P P   E   + +          L   +W+Y    A+   G+  F L+++H      ++
Sbjct  186  YPSPRDLEISKLHIETK------GLSKVYWIYLIAVALNGAGYADFPLIAYHFKKVATVS  239

Query  264  AAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGT  323
               +PV YA AM  DAL AL  G+ +DR G   L +   LS       F       +IG 
Sbjct  240  EQWIPVFYAVAMGVDALAALLFGYLFDRKGLSVLIISVALSAGFAPLCFLGGFYSALIGM  299

Query  324  LVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTL  383
             +WG  +G QES +R  VA LV   +R   YGVF  G G     G  ++G LYD SI  L
Sbjct  300  TLWGIGMGAQESIMRAAVALLVPREKRGIGYGVFNTGYGLFWFLGSVILGVLYDFSISAL  359

Query  384  VVVVIALELMALVMMFAIR  402
            +V  + L+L A+  +  +R
Sbjct  360  IVFSVILQLAAIPFLLRVR  378


>gi|268316173|ref|YP_003289892.1| major facilitator superfamily protein [Rhodothermus marinus DSM 
4252]
 gi|262333707|gb|ACY47504.1| major facilitator superfamily MFS_1 [Rhodothermus marinus DSM 
4252]
Length=393

 Score =  257 bits (657),  Expect = 2e-66, Method: Compositional matrix adjust.
 Identities = 172/398 (44%), Positives = 230/398 (58%), Gaps = 7/398 (1%)

Query  9    LSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGE  68
            ++R  AT     A   + +FG+V LLAD+ YE ARS+ GP L  LGA+   VGVV G GE
Sbjct  1    MTRPAATPTTRRALWLIVLFGLVSLLADLTYESARSLIGPYLGWLGASATAVGVVAGAGE  60

Query  69   AAALGLRLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAV  128
                GLRL SG L+DR+RR+W  T+ GY + ++ VP L +AG   VA AL+IAER GKA+
Sbjct  61   LVGYGLRLASGYLSDRTRRYWTLTLLGYAVNLLAVPALALAGRWEVAAALIIAERAGKAL  120

Query  129  RGPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTL  188
            R P +D LLSHA +  G GRGF +HEALDQ+GA+ GPL +AG+L + G  Y  A  +L +
Sbjct  121  RTPVRDVLLSHATAQVGHGRGFGLHEALDQIGAVAGPLLMAGVL-LQGGDYRTAFALLLV  179

Query  189  PGGAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGT  248
            P   AL LL   + R PRP+  E        P+AP     P  FW+Y     +   G+  
Sbjct  180  PALLALGLLGVARLRYPRPQELEAA-----RPTAPADRTFPRTFWIYLTGAGLLAAGYAD  234

Query  249  FGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVV  308
            F L+++H    GVL  A +P+ YA AM  DA  AL  G  +DR+G  TLA+   L+    
Sbjct  235  FPLIAYHFREAGVLPEAWIPLSYALAMGVDAGAALLLGRWFDRFGPITLALAVALTSAFA  294

Query  309  LFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGG  368
               F        +G  +WG  +G QES LR  +A ++A  RR +A+G+F A  G     G
Sbjct  295  PLTFLGGAAAAWVGMALWGVGMGAQESILRATLARMIAPERRGTAFGLFHAVFGVCWFAG  354

Query  369  GALIGWLYDISIGTLVVVVIALE-LMALVMMFAIRLPR  405
             AL+G LYD SI  LV V +AL+ L ALV+ +  R P+
Sbjct  355  SALLGVLYDTSIPALVGVAVALQVLAALVLGWMSRQPK  392


>gi|282890426|ref|ZP_06298953.1| hypothetical protein pah_c017o007 [Parachlamydia acanthamoebae 
str. Hall's coccus]
 gi|281499680|gb|EFB41972.1| hypothetical protein pah_c017o007 [Parachlamydia acanthamoebae 
str. Hall's coccus]
Length=387

 Score =  257 bits (657),  Expect = 2e-66, Method: Compositional matrix adjust.
 Identities = 160/386 (42%), Positives = 229/386 (60%), Gaps = 13/386 (3%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
             A  FV +FG + L AD+ YEGARSI+G  LA LGA+G VVG V G GE    G RLVSG
Sbjct  9    KAIHFVILFGFISLFADMTYEGARSISGQYLALLGASGAVVGTVAGAGELIGYGFRLVSG  68

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             ++DR+ R+W  T  GY L ++ VPLL +AG   +A +L+I ER GKA+R PAKD LLS+
Sbjct  69   YISDRTGRYWTITFIGYFLNLLAVPLLALAGNWPLAASLMILERFGKAIRNPAKDALLSY  128

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A   TGRG GF +HEA+DQ+GA+ GPL V+G+L + G  Y  +  VL +P   AL++L+ 
Sbjct  129  ATKQTGRGWGFGLHEAMDQIGAITGPLIVSGVLYLQGT-YQASFAVLLIPALCALSVLVA  187

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
                 P PE  E+    L      +      ++WLY    +    G+  F L++FH    
Sbjct  188  TWFLYPNPEEMEEETPNLNTEGFTK------KYWLYIAAISCIAAGYVDFPLIAFHFEKA  241

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFA---FTDNV  316
             +L    +PV++A AMAAD ++AL  G+ YD+ G    +VL  +S +   FA   F   +
Sbjct  242  ALLPEVWIPVLFAIAMAADGISALICGYLYDKIG---FSVLIGVSFIAAFFAPCVFLGGL  298

Query  317  TMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLY  376
            + +V+G ++WG  +G QES +R V+A++V   +RA+AYG+     G A   G AL+G LY
Sbjct  299  SFIVLGAILWGIGLGAQESIVRAVIANMVRMNKRATAYGLMNIYFGIAWFLGSALMGLLY  358

Query  377  DISIGTLVVVVIALELMALVMMFAIR  402
            D S+  LV   +  +  AL + FA++
Sbjct  359  DRSLILLVAFSLIAQFAALPLFFAVK  384


>gi|332668938|ref|YP_004451946.1| major facilitator superfamily protein [Cellulomonas fimi ATCC 
484]
 gi|332337976|gb|AEE44559.1| major facilitator superfamily MFS_1 [Cellulomonas fimi ATCC 484]
Length=410

 Score =  255 bits (651),  Expect = 1e-65, Method: Compositional matrix adjust.
 Identities = 168/348 (49%), Positives = 223/348 (65%), Gaps = 11/348 (3%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
            +AWR V   GVV L AD+VYEGARS+TGPLLA LG   +V G+VTG+GEAAAL LRL  G
Sbjct  12   AAWRVVLGLGVVSLAADMVYEGARSVTGPLLALLGVPMVVAGLVTGLGEAAALVLRLPFG  71

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGI-----AGALWVACALVIAERVGKAVRGPAKD  134
              ADR  R+W  T+AGY LT V VPLL +     AG   VACAL++ ERVGKAVR P+K 
Sbjct  72   ARADRVGRYWPTTLAGYGLTAVGVPLLAVTPLLGAGGAAVACALLLLERVGKAVRSPSKS  131

Query  135  TLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAAL  194
             LL+ AA   G GRGF VH+A+DQ+GA +GPL VAG+LA TG+  +P+L VL +PG  A+
Sbjct  132  VLLARAAEDVGLGRGFGVHKAMDQLGAFVGPLLVAGVLAATGS-LSPSLAVLAVPGAVAM  190

Query  195  ALLLWLQRRVPRPESYEDCPVVLGNPSAPRPW-----ALPAQFWLYCGFTAITMLGFGTF  249
             LL+ ++R  P           +G P+    W      LP  FW +    A    G  TF
Sbjct  191  LLLVAVRRLAPDDPPPTTVDPRVGTPAGRGAWLRPARELPRPFWSFAAAAAAVGAGLTTF  250

Query  250  GLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVL  309
             ++S+H+V  G+L AA+VPVVYA AM A A+ AL  G  +DR+G + +  +P+L+  V  
Sbjct  251  AVISYHLVDEGLLDAALVPVVYAGAMLAAAVGALVVGAVHDRFGPRVVLAVPVLAAAVPP  310

Query  310  FAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVF  357
             AF   +  V++G ++WG A G+ +ST++  VA+LV + RRA+AYG F
Sbjct  311  LAFGATLPAVLVGVVLWGLAGGLLDSTVKARVAELVPAGRRATAYGWF  358


>gi|260893310|ref|YP_003239407.1| major facilitator superfamily MFS_1 [Ammonifex degensii KC4]
 gi|260865451|gb|ACX52557.1| major facilitator superfamily MFS_1 [Ammonifex degensii KC4]
Length=395

 Score =  254 bits (650),  Expect = 1e-65, Method: Compositional matrix adjust.
 Identities = 154/381 (41%), Positives = 222/381 (59%), Gaps = 4/381 (1%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            AW F+   G+V L  D+ YEGARSI GP +ASLGA+  +VG   G+GE     LRL+ G 
Sbjct  4    AWLFIFFMGLVSLFGDITYEGARSIIGPFMASLGASAAIVGFFAGLGELGGYALRLIGGY  63

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
            LADR+ R+W  T  GY + ++ VP L +AG    A AL++ ER GK +R P +D +LS+A
Sbjct  64   LADRTERYWLLTGLGYLVNLLAVPSLALAGRWETAAALMVIERAGKGLRTPPRDAMLSYA  123

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWL  200
             S  GRG GF  HEA+DQ+GA+ GPL  AG+L++ G  +  +  +  +P   AL +L W 
Sbjct  124  TSQVGRGWGFGFHEAMDQIGAITGPLLAAGVLSL-GWTFRQSFALYAVPAFLALIILAWA  182

Query  201  QRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHG  260
            +   P P+  E          +PR    P  +W Y  F+A+ + GF  F +L++H     
Sbjct  183  RISFPVPKELEISLRSSPETDSPR---FPQAYWYYLAFSAVAVAGFLHFQILAYHFKVKE  239

Query  261  VLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVV  320
            VL+ A +P +YA AMA DA  AL +G  YDR G ++L ++P L++L+       +   VV
Sbjct  240  VLSDAAIPFLYAGAMATDAAAALLAGRFYDRIGLRSLIIVPFLTVLLTFLVLATHPLPVV  299

Query  321  IGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISI  380
             GTL+WG  +G+ ESTLR  +ADL    RR   YG+F    G A    GAL+G LYD S 
Sbjct  300  AGTLIWGVVMGLHESTLRAAIADLTPIARRGLGYGIFNTVYGTAAFLSGALLGMLYDRSP  359

Query  381  GTLVVVVIALELMALVMMFAI  401
              ++++V+ LE +A ++   +
Sbjct  360  HEVIILVVVLEAIAFLIFLQM  380


>gi|337288257|ref|YP_004627729.1| major facilitator superfamily protein [Thermodesulfobacterium 
sp. OPB45]
 gi|334901995|gb|AEH22801.1| major facilitator superfamily MFS_1 [Thermodesulfobacterium sp. 
OPB45]
Length=383

 Score =  254 bits (650),  Expect = 1e-65, Method: Compositional matrix adjust.
 Identities = 147/384 (39%), Positives = 218/384 (57%), Gaps = 9/384 (2%)

Query  24   FVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLAD  83
            FV + G+V L +D+ YEGARSITGP L  LGA   VVG  +G GE    GLRL SG LAD
Sbjct  9    FVILLGLVSLFSDMTYEGARSITGPYLFYLGAGAAVVGFASGFGEFIGYGLRLFSGWLAD  68

Query  84   RSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASV  143
            +++++W     GY L +++VP L +  +  +A  L+I ER GKA+R PA+DTLLS+A   
Sbjct  69   KTKKYWGLMFIGYALNLLSVPALALVNSWGLAVLLIILERTGKALRTPARDTLLSYATFK  128

Query  144  TGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRR  203
             GRG GF +HEA+DQ+GA +GPL VA +  +    Y PA  VL +P   AL+LL + +  
Sbjct  129  MGRGLGFGIHEAMDQIGAFVGPLIVALVFYLK-MGYKPAFLVLLIPALIALSLLTFARII  187

Query  204  VPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLA  263
             P P+ +E   + L      +       FW Y     +   GF  F L+ +H+    +L+
Sbjct  188  YPAPQKFEKGFLELETKGFSK------SFWWYLLGMCLVGAGFVDFPLIGYHLEKTSILS  241

Query  264  AAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGT  323
               +P++YA AM  DA +A+  G  +DR G K + +  ILS+  +   F   + ++ +G 
Sbjct  242  KDWIPILYALAMGVDAFSAIFLGLLFDRIGLKAVILAIILSLGAIPLTFLGGIILIFLGM  301

Query  324  LVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTL  383
            ++WG  +G QES +R V+A LV   +R   YG+F    G     G  L+G+LYD SI  L
Sbjct  302  ILWGIGLGAQESIMRAVIAQLVPIEKRGVGYGIFNTFFGLFWFVGSFLLGFLYDFSI--L  359

Query  384  VVVVIALELMALVMMFAIRLPRVA  407
             +V  ++   AL + F +++ + A
Sbjct  360  ALVAFSVTFQALSIPFILKVAKTA  383


>gi|333896447|ref|YP_004470321.1| major facilitator superfamily MFS_1 [Thermoanaerobacterium xylanolyticum 
LX-11]
 gi|333111712|gb|AEF16649.1| major facilitator superfamily MFS_1 [Thermoanaerobacterium xylanolyticum 
LX-11]
Length=394

 Score =  254 bits (649),  Expect = 2e-65, Method: Compositional matrix adjust.
 Identities = 138/377 (37%), Positives = 214/377 (57%), Gaps = 14/377 (3%)

Query  25   VTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLADR  84
            + + G+V    D+ YEGARS+ GP L  LGA  L+VG+VTG+GE  A  +R+  G   D+
Sbjct  15   ILLLGIVSAFGDITYEGARSVYGPYLKLLGANALIVGIVTGIGEFLASAIRIPVGYAIDK  74

Query  85   SRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVT  144
            + + W WTI GY + +++VPLL I G   +A  L+I ER GKA+R P KDT+LSH +   
Sbjct  75   TSKPWLWTILGYGM-LISVPLLAITGKWPIAALLIILERTGKAIRSPGKDTILSHVSKKI  133

Query  145  GRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRRV  204
            G G GF +HE LDQ+G +IGPL    +++  G +Y     ++ +P    +  +++ + +V
Sbjct  134  GTGLGFGLHELLDQIGGIIGPLIFTFVISFAG-SYKTGFILMWIPAILTVIFVIYARSKV  192

Query  205  PRPESYEDC------PVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVS  258
              P   E         V L N +  R      Q+  Y  F    MLGF  + ++S+H +S
Sbjct  193  TNPAELEKNTKNASKNVDLLNKNFSR------QYLYYMLFIFFAMLGFANYPIISYHFLS  246

Query  259  HGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTM  318
            H VL+   +P++YA AMA D ++A+  G  YD+ G  +LAVLPI + L+    F++   +
Sbjct  247  HKVLSQDAIPLLYALAMAVDGVSAVFIGKFYDKKGFLSLAVLPISTFLMTFMVFSNMPVL  306

Query  319  VVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDI  378
             ++  L+WG    +QE+T+R V+ D+     R  A+GVF+A  G +   G  + G+LY  
Sbjct  307  AIVSMLIWGFITSMQETTMRSVITDITYISERGKAFGVFSAVTGFSMFLGSTIFGYLYAH  366

Query  379  SIGTLVVVVIALELMAL  395
            SI  + +  I  E++AL
Sbjct  367  SINFIFLYSIIAEMIAL  383


>gi|160901703|ref|YP_001567284.1| major facilitator transporter [Petrotoga mobilis SJ95]
 gi|160359347|gb|ABX30961.1| major facilitator superfamily MFS_1 [Petrotoga mobilis SJ95]
Length=382

 Score =  253 bits (645),  Expect = 5e-65, Method: Compositional matrix adjust.
 Identities = 148/379 (40%), Positives = 227/379 (60%), Gaps = 11/379 (2%)

Query  29   GVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRRF  88
            G+V L AD+ +EGARS+ GP L  LGA+   VG+++G+GE    GLRL++G L+D++ R+
Sbjct  2    GIVSLFADITHEGARSLIGPYLGLLGASATAVGIISGLGEFIGYGLRLLTGYLSDKTHRY  61

Query  89   WAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASVTGRGR  148
            W +T  GY + +  VPLL +AG   +A  L+I ER GKA+R P+KDTL+S+AA   G G+
Sbjct  62   WLFTFLGYGMDLFAVPLLALAGRWEIAAMLIIMERTGKAIRKPSKDTLMSYAARNVGSGK  121

Query  149  GFAVHEALDQVGAMIGPLTVAGMLAI-TGNA---YAPALGVLTLPGGAALALLLWLQRRV  204
            GFA+ E LDQ+GA+ GP+ ++ +L   +G+    Y  A  +L +P    L LLL  +   
Sbjct  122  GFAIAEVLDQIGAVSGPVILSLILLFKSGDELANYRFAFAILLIPALITLILLLISRLNF  181

Query  205  PRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLAA  264
            P+PE +E     +      +       +WLY    ++   GF  F LL+FH     +  +
Sbjct  182  PQPEKFEVKEEKINFEGISK------SYWLYLVAISLIAAGFADFPLLAFHFQRIDIFNS  235

Query  265  AMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAF-TDNVTMVVIGT  323
             M+P +YA AM  DA++AL  GF YD+ G  +L +   LSI    F+F +++  +V++G 
Sbjct  236  TMIPFMYAIAMGVDAISALIFGFLYDKVGVTSLIIASSLSIFFSPFSFLSESSLLVILGV  295

Query  324  LVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTL  383
            ++WG  +G QES L+ VVAD+V   +R +AYG F A  G     G A++G LYD +I +L
Sbjct  296  ILWGIGMGAQESILKSVVADIVTPEKRGTAYGFFNAIFGLFWFIGSAVMGILYDRAIVSL  355

Query  384  VVVVIALELMALVMMFAIR  402
            VV  + +E  A+  +F ++
Sbjct  356  VVFSMIVESAAVFTLFLLK  374


>gi|159038076|ref|YP_001537329.1| major facilitator transporter [Salinispora arenicola CNS-205]
 gi|157916911|gb|ABV98338.1| major facilitator superfamily MFS_1 [Salinispora arenicola CNS-205]
Length=419

 Score =  253 bits (645),  Expect = 6e-65, Method: Compositional matrix adjust.
 Identities = 193/373 (52%), Positives = 240/373 (65%), Gaps = 8/373 (2%)

Query  15   TRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGL  74
            T P  S WR V  FGVV L AD+VYEGARS+ GPLLASLGA+ L+VG++TG GEAAAL L
Sbjct  20   TSPGWSPWRTVIGFGVVSLAADMVYEGARSVYGPLLASLGASALIVGLITGAGEAAALVL  79

Query  75   RLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGI-----AGALWVACALVIAERVGKAVR  129
            RLVSGPLADR+RR+W  TI GY LT V VPLL +     A  L +A  L++AER+GKAVR
Sbjct  80   RLVSGPLADRTRRYWTLTIVGYALTAVCVPLLAVTPRLGAAGLVLAGLLIVAERLGKAVR  139

Query  130  GPAKDTLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLP  189
             PAK  LL+ AA   G GRG  VH+ALDQVGA  GPL +A + A  G    P L  L +P
Sbjct  140  SPAKSALLAEAAGAVGMGRGMGVHKALDQVGAFAGPLLLAALAAAAGGLLWPGLAALAVP  199

Query  190  GGAALALLLWLQRRVP--RPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFG  247
            G  A+ +L+ ++RR    RP    D         AP P +LPA F  +    A+   G  
Sbjct  200  GALAMVMLVVIRRRTEPVRPPGAADGHRTERGTIAP-PTSLPASFVWFAVACALCTAGLM  258

Query  248  TFGLLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILV  307
            TFGL+ FH+    V+ AA VP++YA AMAA A  ALA+G +YDR GA+ L VLP+L  +V
Sbjct  259  TFGLIGFHLAQTDVVPAAGVPLLYAVAMAAAAAAALATGTAYDRIGARVLLVLPVLVAVV  318

Query  308  VLFAFTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAG  367
               AFT  + +   G +VWGAA+G+Q+ST++  VADLV   RRA+AYGVFAA  GA    
Sbjct  319  PPLAFTTGLAVAAAGVVVWGAALGVQDSTVKAFVADLVPRQRRATAYGVFAAVQGAGALV  378

Query  368  GGALIGWLYDISI  380
            GG   G LY+ S+
Sbjct  379  GGVTAGTLYESSL  391


>gi|222099533|ref|YP_002534101.1| Major facilitator superfamily MFS_1 precursor [Thermotoga neapolitana 
DSM 4359]
 gi|221571923|gb|ACM22735.1| Major facilitator superfamily MFS_1 precursor [Thermotoga neapolitana 
DSM 4359]
Length=384

 Score =  252 bits (644),  Expect = 8e-65, Method: Compositional matrix adjust.
 Identities = 155/388 (40%), Positives = 225/388 (58%), Gaps = 9/388 (2%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
             A+ F+ + G+V L AD+ YEGARSI GP + +LGA+   +G   G+GE      RLVSG
Sbjct  5    QAFLFIILLGLVSLFADITYEGARSIVGPFMKTLGASAATLGFAVGLGELIGYAFRLVSG  64

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+D ++++W +TI GYT+ ++ VP+L  AG   VA AL++ ER GKA+R PA+DTLLS 
Sbjct  65   VLSDVTKKYWLFTILGYTVNLLAVPMLAFAGNWQVALALILMERFGKALRTPARDTLLSF  124

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            AA   G G+ F +HEALDQVGA++GPL+V   LA  G +Y     VL +P   ALALL  
Sbjct  125  AAEEIGTGKSFGIHEALDQVGAILGPLSVTFALAF-GKSYRFCFFVLFIPALVALALL--  181

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
            L  R+  P +      V    SA R   L   +W Y    ++   GF  F L+++HM + 
Sbjct  182  LTARIVFPST--RIEKVKKVRSADRN--LGRTYWFYLLVVSMIAFGFADFPLIAYHMKNF  237

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
                  +VP VY+ AMA DA++AL  G+ +DR G   L    +LS    +F+F+    ++
Sbjct  238  ETTKDFLVPAVYSLAMAVDAVSALVFGYLFDRKGFPALLYPVLLSAFFPIFSFSGYFPLI  297

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
              GT++WG  +G QES +R  VA +V+  +R  AYG+F    G     G  ++G LYD +
Sbjct  298  FAGTVLWGIGMGAQESIMRAAVAKIVSQEKRGFAYGMFFTVYGVFWFLGSWILGILYDTN  357

Query  380  IGTLVVVVIALELMALVMMFAIRLPRVA  407
               L++V +  +L+A  ++F  R  R A
Sbjct  358  RLYLILVSLFSQLIAFALLF--RFKRTA  383


>gi|304439966|ref|ZP_07399859.1| major facilitator family transporter [Peptoniphilus duerdenii 
ATCC BAA-1640]
 gi|304371458|gb|EFM25071.1| major facilitator family transporter [Peptoniphilus duerdenii 
ATCC BAA-1640]
Length=405

 Score =  251 bits (642),  Expect = 1e-64, Method: Compositional matrix adjust.
 Identities = 143/400 (36%), Positives = 223/400 (56%), Gaps = 23/400 (5%)

Query  24   FVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLAD  83
            F+ +FG+V L +D+ +EGA S+ G  L+ LGA+   +G ++G+GE     LR   G L D
Sbjct  12   FIILFGIVSLFSDMTHEGASSLRGVYLSLLGASAGTIGFISGLGELVGYSLRYFFGKLTD  71

Query  84   RSRRFWAWTIAGYTLTVVTVPLLGIAGAL-WV-ACALVIAERVGKAVRGPAKDTLLSHAA  141
            ++ ++W  TI GY L ++ VP L + G+  W+  C L++ +R+GKA++ PAKDT++S AA
Sbjct  72   KTHKYWQMTIFGYVLDILAVPALALVGSDGWIYGCGLLVIQRMGKAIKKPAKDTIMSFAA  131

Query  142  SVTGRGRGFAVHEALDQVGAMIGP--LTVAGMLAITGNA---YAPALGVLTLPGGAALAL  196
            S  G G+ FA+ E LDQ+GA +GP  L V  +    G     Y+     L +PG   L L
Sbjct  132  SQEGAGKSFAIQEMLDQIGAFLGPFFLYVVMLFKTDGTTFEIYSRCFAYLAIPGVITLIL  191

Query  197  LLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHM  256
            L++ ++R P PE +E        P    P+ +   F  Y    ++   GF  + L+  H+
Sbjct  192  LIYTKKRFPNPEHFEP------EPKEYIPFKMKDSFIFYIIGISLFSFGFIDYSLIIMHV  245

Query  257  VSH--------GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVV  308
              +        G++    +P++YAAAM  DA++AL  G  YDR G K L V  I+S    
Sbjct  246  SKNLNVLTNGVGLINMETIPLIYAAAMLVDAISALIFGIMYDRNGVKALVVSTIISAPFS  305

Query  309  LFAF-TDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAG  367
            LF F  +N+ +V++G ++WG  +G QES L+  V  +V    RA+ YG+F    G     
Sbjct  306  LFIFGFNNIYVVLLGIILWGVGMGAQESILKAAVTSVVPKSSRATGYGIFEMSFGVFWFL  365

Query  368  GGALIGWLYDISIGTLVVVVIALELMALVMMF-AIRLPRV  406
            G  L+G LYDI+I +L++V +  +L+++   F A R  RV
Sbjct  366  GSWLLGVLYDINITSLIIVSMMTQLLSIPFYFKASRAKRV  405


>gi|288817525|ref|YP_003431872.1| permease of the major facilitator superfamily [Hydrogenobacter 
thermophilus TK-6]
 gi|288786924|dbj|BAI68671.1| permease of the major facilitator superfamily [Hydrogenobacter 
thermophilus TK-6]
 gi|308751128|gb|ADO44611.1| major facilitator superfamily MFS_1 [Hydrogenobacter thermophilus 
TK-6]
Length=392

 Score =  251 bits (641),  Expect = 1e-64, Method: Compositional matrix adjust.
 Identities = 150/379 (40%), Positives = 224/379 (60%), Gaps = 10/379 (2%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            A+R V +FG+V LLAD+ YEGARSI GP ++ LGA+   V  + G+GE     LRLV G 
Sbjct  10   AYRIVLLFGIVSLLADLTYEGARSIVGPYMSLLGASAFAVSFIAGLGEFVGYALRLVFGY  69

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
            LADR+R +W  TI GY + + +VPLL +A +   A  L++ ER+GK+VR P++D LLS A
Sbjct  70   LADRTRLYWGITITGYLINLFSVPLLALAPSWQWAGFLLLLERMGKSVRAPSRDALLSFA  129

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWL  200
                G G GF VHE  DQ+GA+ GPL V+ ++ +TGN Y  A  +L +P  A +ALL  +
Sbjct  130  TKRMGHGLGFGVHEFFDQIGALSGPLLVSAVMFLTGN-YRLAFALLGVP--AFMALLTLI  186

Query  201  QRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHG  260
              R+   ES      V  +    R   L + F+LY   +++  +G+  F L+++H+ +  
Sbjct  187  YTRISYTES------VKKDAEEERD-QLKSTFFLYILASSLVAMGYADFALMAYHIKTSA  239

Query  261  VLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVV  320
            +L    VP++YAAAM  DA+ AL  G  +DR G   L +  +L+    LFAF+ +V  V 
Sbjct  240  LLPDGWVPLLYAAAMGVDAIFALLFGVLFDRIGFYALMLGVLLASPFSLFAFSLSVPAVC  299

Query  321  IGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISI  380
            IG  +WG  +GIQES +R  +A L     R  A+G+F    G     G A++G+LY +S+
Sbjct  300  IGIALWGLGMGIQESIMRSAIAKLTPPQARGKAFGIFHFFYGLFWFIGSAILGYLYQVSL  359

Query  381  GTLVVVVIALELMALVMMF  399
              L+   +  ++++LV +F
Sbjct  360  AYLMTFSVLCQIISLVPLF  378


>gi|15642905|ref|NP_227946.1| hypothetical protein TM0130 [Thermotoga maritima MSB8]
 gi|4980623|gb|AAD35224.1|AE001699_1 conserved hypothetical protein [Thermotoga maritima MSB8]
Length=384

 Score =  250 bits (639),  Expect = 3e-64, Method: Compositional matrix adjust.
 Identities = 141/386 (37%), Positives = 217/386 (57%), Gaps = 9/386 (2%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
             A+ F+ + G+V L ADV YEGARSI GP + +LGA+   +G   G+GE      RL+SG
Sbjct  5    KAFLFIVLLGLVSLFADVTYEGARSIIGPFMKTLGASAAALGFAVGLGELTGYAFRLISG  64

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+D++R++W +TI GY + +  VP L  AG    A  L+IAER GKA+R PA+D LLS 
Sbjct  65   ILSDKTRKYWLFTILGYAINLFAVPALAFAGNWQTALVLIIAERFGKALRTPARDVLLSF  124

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A+   G G+GF +HEALDQ+GA++GPL +   LA    +Y     +L +P  A +A++L 
Sbjct  125  ASEEVGMGKGFGIHEALDQIGAILGPLALTFALAFE-KSYRFCFFILLIP--ALVAMVLL  181

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
            L  R+  P   E    +     +P    L   +W Y    ++    F  F ++++HM S 
Sbjct  182  LTARITFPALQE----MKKKKDSPVDRNLGKTYWFYLAIVSMVAFAFADFPIIAYHMKSF  237

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
             V     VP  Y+ AMA DA+ AL  G  +D+ G   LA   +LS    + +F+++  ++
Sbjct  238  EVAKDFFVPATYSLAMAVDAVAALVFGHLFDKKGFVALAYAVLLSSFFPVLSFSNSFPLI  297

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
              G ++WG  +G QES +R VVA +V + +R  AYG+F    G     G  ++G LYDI+
Sbjct  298  FAGVILWGIGMGAQESIMRAVVAKIVPAEKRGFAYGMFFTVYGVFWFFGSWIMGTLYDIN  357

Query  380  IGTLVVVVIALELMALVMMFAIRLPR  405
               L++    ++  A +++  +R+ R
Sbjct  358  RFYLILFSFVIQFAAALLL--LRMKR  381


>gi|313673903|ref|YP_004052014.1| major facilitator superfamily mfs_1 [Calditerrivibrio nitroreducens 
DSM 19672]
 gi|312940659|gb|ADR19851.1| major facilitator superfamily MFS_1 [Calditerrivibrio nitroreducens 
DSM 19672]
Length=382

 Score =  250 bits (639),  Expect = 3e-64, Method: Compositional matrix adjust.
 Identities = 144/379 (38%), Positives = 210/379 (56%), Gaps = 7/379 (1%)

Query  24   FVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLAD  83
            F+ + G+V L +D+ YE ARSITGP LA LG T  VVG + G+GE     LRL SG LAD
Sbjct  7    FIVLLGLVSLFSDMTYEAARSITGPFLAFLGTTATVVGFIAGLGEFIGYALRLFSGWLAD  66

Query  84   RSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHAASV  143
            ++ ++W+  IAGY + +++VP L + G   +A  L++AER GKA+R P++D +LS+A   
Sbjct  67   KTGKYWSIAIAGYLINLLSVPALALVGQWQLAALLIMAERTGKAIRTPSRDAMLSYATVQ  126

Query  144  TGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQRR  203
             G G GF +HEA+DQ+GAM+GPL VA +    G  Y  A  VL +P   A+ +LL+ +  
Sbjct  127  IGHGCGFGLHEAMDQIGAMVGPLIVAAVFYFHGG-YKEAFAVLLIPAAIAITILLFARFL  185

Query  204  VPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHGVLA  263
             P P+  E   + +   S      L   +WLY    A+   G+  F L+++H      ++
Sbjct  186  YPSPKDLEIPKLQIETKS------LSKVYWLYLIAVALNGAGYADFPLIAYHFKKVATVS  239

Query  264  AAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMVVIGT  323
               +PV YA AM  DAL AL  G+ +D+ G   L    ++S     F F       + G 
Sbjct  240  EHWIPVFYAMAMGIDALAALIFGYLFDKKGLSILIFSVLISAGFAPFCFLGGFYSALFGM  299

Query  324  LVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDISIGTL  383
            L+WG  +G QES +R  VA LV   +R   YGVF  G G     G   +G LYD S+  L
Sbjct  300  LLWGIGMGAQESIMRAAVAVLVPKEKRGIGYGVFNTGYGLFWFLGSTALGLLYDFSVSAL  359

Query  384  VVVVIALELMALVMMFAIR  402
            V+  + L+L ++  +  +R
Sbjct  360  VLFSVLLQLSSIPFLIRVR  378


>gi|206895704|ref|YP_002246633.1| hypothetical protein COPRO5265_0265 [Coprothermobacter proteolyticus 
DSM 5265]
 gi|206738321|gb|ACI17399.1| conserved protein [Coprothermobacter proteolyticus DSM 5265]
Length=397

 Score =  248 bits (632),  Expect = 2e-63, Method: Compositional matrix adjust.
 Identities = 150/383 (40%), Positives = 221/383 (58%), Gaps = 8/383 (2%)

Query  21   AWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGP  80
            A+ F+ + G+V LLADV YEGARS+TGP L  LGA+  VVG   G GE      RLVSG 
Sbjct  13   AFYFIILLGLVSLLADVTYEGARSVTGPYLGLLGASSAVVGFAAGFGEMLGYAFRLVSGY  72

Query  81   LADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSHA  140
             ADR+ R+W  TI GY L ++ +PLL   G   VA  L+I ER+GK +R PA+D +LS A
Sbjct  73   WADRTHRYWLLTIVGYALNLLAIPLLAFVGNWQVAVLLLILERLGKGLRTPARDVMLSQA  132

Query  141  ASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWL  200
                GRG GF +HEA+DQ+GA+ GP+ V+ +LA     Y  A   L +P   A+ L++  
Sbjct  133  TKQVGRGFGFGLHEAMDQIGAVAGPVFVSIVLA-RNLGYRDAFLFLGIPAILAMILVVTA  191

Query  201  QRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSHG  260
            +   P+P+ +E  P   G  +          FW+Y G  A+   G+  + L+ +H+  +G
Sbjct  192  RFLYPKPQEFE--PAYKGIETK----GYSKAFWIYLGAVALIGAGYIDYPLIGYHLQQNG  245

Query  261  VLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTM-V  319
            +L A  + ++Y+ AM  DAL+AL  G  +DR G   + V  +++ L   FAF  +V    
Sbjct  246  ILQAQFIALLYSLAMGIDALSALVFGAWFDRAGVSVVGVSALIAALFSPFAFLLHVWWGP  305

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
            VIG ++WG  +G QES +R  +A+++ + RR  AYG F    G A   G  ++G +Y  S
Sbjct  306  VIGMVLWGIGMGAQESVMRAALAEMIPTERRGVAYGFFNTVYGLAWFAGSFVMGIIYGFS  365

Query  380  IGTLVVVVIALELMALVMMFAIR  402
               +V+V + LEL+A +++F  R
Sbjct  366  PTLMVIVSVTLELLAALLIFVNR  388


>gi|116669256|ref|YP_830189.1| major facilitator transporter [Arthrobacter sp. FB24]
 gi|116609365|gb|ABK02089.1| major facilitator superfamily MFS_1 [Arthrobacter sp. FB24]
Length=415

 Score =  246 bits (629),  Expect = 4e-63, Method: Compositional matrix adjust.
 Identities = 169/348 (49%), Positives = 224/348 (65%), Gaps = 17/348 (4%)

Query  28   FGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSGPLADRSRR  87
            FG+V L  D V +GAR + GPLLA LGA+ LVVG+VTG  EAAA GLRL+ GP ADR+ +
Sbjct  5    FGLVSLAVDAVSDGARPLAGPLLAQLGASALVVGLVTGAAEAAAQGLRLLFGPWADRTGK  64

Query  88   FWAWTIAGYTLTVVTVPLLGI-----AGALWVACALVIAERVGKAVRGPAKDTLLSHAAS  142
            +W +TIAGY LTV+ VPLL +     A  L +A AL+I +RVGKAVR PAK  LL+  A 
Sbjct  65   YWTFTIAGYALTVLCVPLLAVTPVVGAAGLVLASALIIGDRVGKAVRSPAKTVLLASVAG  124

Query  143  VTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLWLQR  202
              GRGRGFAVH++LD  GA  GPL  + ++A TG+ + PA  VL +PG  A+ALL  ++ 
Sbjct  125  PVGRGRGFAVHKSLDLAGAFAGPLIASAVIAATGSLW-PAFAVLAIPGALAMALLFRIRG  183

Query  203  RVPRPESYED---CPVVLGNPSAP---RPWA-----LPAQFWLYCGFTAITMLGFGTFGL  251
            RVP P+   +    PV+   P  P   +P       LP  F L+         G   FG+
Sbjct  184  RVPEPQRTAEQLVTPVLPDAPDTPGGLKPADTPAGRLPGVFLLFALSAFFWSAGLVAFGV  243

Query  252  LSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFA  311
            ++FH+ +   +  + VP+VYAAAMAA AL ALASG+ YDR G   L VLP+L  ++ + A
Sbjct  244  IAFHLTAAVDVPVSAVPLVYAAAMAAAALGALASGYGYDRAGGAVLLVLPVLVAVIPVLA  303

Query  312  FTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAA  359
            F+ +   V+ G LVWGAA GIQ+ST++ +VADLV   R+ +AYG+FAA
Sbjct  304  FSVSTGPVLGGVLVWGAATGIQDSTVKALVADLVVPARQGTAYGIFAA  351


>gi|157363592|ref|YP_001470359.1| major facilitator transporter [Thermotoga lettingae TMO]
 gi|157314196|gb|ABV33295.1| major facilitator superfamily MFS_1 [Thermotoga lettingae TMO]
Length=389

 Score =  244 bits (624),  Expect = 1e-62, Method: Compositional matrix adjust.
 Identities = 149/396 (38%), Positives = 226/396 (58%), Gaps = 21/396 (5%)

Query  15   TRPALSAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGL  74
            T+ AL+   F+ + G V L +D+VYEGARSI+GP L  LGA+  VV    G+GE     L
Sbjct  5    TKRALA---FIVLMGFVSLFSDIVYEGARSISGPFLGLLGASATVVAFTAGLGEFIGYAL  61

Query  75   RLVSGPLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKD  134
            RLV+G LA +++R+W +T  GY + +  VP L +AG   +A  L+++ER GKA+R P++D
Sbjct  62   RLVTGYLAGKTKRYWLFTFVGYFMNLFAVPALALAGNWQLAVLLLLSERFGKAIRKPSRD  121

Query  135  TLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGN----AYAPALGVLTLPG  190
            T++S+AA   G G GF + EALDQVGA+ GP+ ++ +L++        Y  A  VL  P 
Sbjct  122  TMMSYAAKQVGTGFGFGLEEALDQVGAISGPVILSLVLSLKAGEEFAKYKLAFSVLFFPA  181

Query  191  GAALALLLWLQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFG  250
              A+ LL+  +   P P  +E+        S P        F LY    ++   GF  F 
Sbjct  182  LIAIILLICGRIFFPEPGEFEE-------KSTPGGKITTNGFALYMVAISLIAAGFSDFP  234

Query  251  LLSFHMVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLF  310
            L+SFH   + +L+++ +P+ Y+ AMA DA+ AL  G  +D+ G   + VL I S L  LF
Sbjct  235  LISFHFAKNHILSSSTIPLFYSIAMAVDAVAALFFGKLFDKKG---IMVLIISSALSALF  291

Query  311  A----FTDNVTMVVIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATA  366
            A     T N+ ++ +G  +WG  +G QES L+ VVA+LV+  +RA AYG+F    G    
Sbjct  292  APLVFLTKNIFLISVGVSLWGIGMGAQESILKAVVANLVSREKRAFAYGIFNTVFGLFWF  351

Query  367  GGGALIGWLYDISIGTLVVVVIALELMALVMMFAIR  402
             G   +G LY+ S+  LV+  +  EL ++ ++  +R
Sbjct  352  LGSLFMGILYEKSLLLLVIFSVVSELSSVFVLLGLR  387


>gi|148269929|ref|YP_001244389.1| major facilitator transporter [Thermotoga petrophila RKU-1]
 gi|170288614|ref|YP_001738852.1| major facilitator transporter [Thermotoga sp. RQ2]
 gi|281412190|ref|YP_003346269.1| major facilitator superfamily MFS_1 [Thermotoga naphthophila 
RKU-10]
 gi|147735473|gb|ABQ46813.1| major facilitator superfamily MFS_1 [Thermotoga petrophila RKU-1]
 gi|170176117|gb|ACB09169.1| major facilitator superfamily MFS_1 [Thermotoga sp. RQ2]
 gi|281373293|gb|ADA66855.1| major facilitator superfamily MFS_1 [Thermotoga naphthophila 
RKU-10]
Length=384

 Score =  244 bits (623),  Expect = 2e-62, Method: Compositional matrix adjust.
 Identities = 141/386 (37%), Positives = 215/386 (56%), Gaps = 9/386 (2%)

Query  20   SAWRFVTVFGVVGLLADVVYEGARSITGPLLASLGATGLVVGVVTGVGEAAALGLRLVSG  79
             A+ F+ + G+V L ADV YEGARSI GP + +LGA+   +G   G+GE      RL+SG
Sbjct  5    KAFLFIVLLGLVSLFADVTYEGARSIIGPFMKTLGASAAALGFAVGLGELTGYAFRLISG  64

Query  80   PLADRSRRFWAWTIAGYTLTVVTVPLLGIAGALWVACALVIAERVGKAVRGPAKDTLLSH  139
             L+D++R++W +TI GY + +  VP L +AG    A  L+IAER GKA+R PA+D LLS 
Sbjct  65   ILSDKTRKYWLFTILGYAINLFAVPALALAGNWQTALVLIIAERFGKALRTPARDVLLSF  124

Query  140  AASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALGVLTLPGGAALALLLW  199
            A+   G G+GF +HEALDQ+GA++GPL +   LA  G +Y     +L +P   A+ LLL 
Sbjct  125  ASEEVGMGKGFGIHEALDQIGAILGPLALTFALAF-GKSYRFCFFILLIPALVAMVLLLT  183

Query  200  LQRRVPRPESYEDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTFGLLSFHMVSH  259
             +   P P+  +           P    L   +W Y    ++    F  F ++++HM S 
Sbjct  184  ARITFPAPQEMKK------RKDNPVDRNLGKTYWFYLAIVSMVAFAFVDFPIIAYHMKSF  237

Query  260  GVLAAAMVPVVYAAAMAADALTALASGFSYDRYGAKTLAVLPILSILVVLFAFTDNVTMV  319
             V      P  Y+ AMA DA+ AL  G  +D+ G   LA   +LS    L +F+++  ++
Sbjct  238  EVTKDFFAPATYSLAMAVDAVAALVFGHLFDKKGFVALAYALLLSSFFPLLSFSNSFPLI  297

Query  320  VIGTLVWGAAVGIQESTLRGVVADLVASPRRASAYGVFAAGLGAATAGGGALIGWLYDIS  379
              G ++WG  +G QES +R VVA +V + +R  AYG+F    G     G  ++G LYDI+
Sbjct  298  FAGVILWGIGMGAQESIMRAVVAKIVPAEKRGFAYGMFFTVYGVFWFSGSWIMGTLYDIN  357

Query  380  IGTLVVVVIALELMALVMMFAIRLPR  405
               L++    ++  A +++  +R+ R
Sbjct  358  RFYLILFSFVIQFAAALLL--LRMKR  381



Lambda     K      H
   0.325    0.139    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 816290083944


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40