BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2276 Length=396 Score E Sequences producing significant alignments: (Bits) Value gi|15609413|ref|NP_216792.1| cytochrome P450 121 CYP121 [Mycobac... 800 0.0 gi|206581996|pdb|3CY1|A Chain A, Crystal Structure Of The Cytoch... 798 0.0 gi|206581995|pdb|3CY0|A Chain A, Crystal Structure Of Cytochrome... 798 0.0 gi|206581991|pdb|3CXV|A Chain A, Crystal Structure Of The Cytoch... 798 0.0 gi|289745551|ref|ZP_06504929.1| cytochrome p450 121 cyp121 [Myco... 798 0.0 gi|206581992|pdb|3CXX|A Chain A, Crystal Structure Of Cytochrome... 798 0.0 gi|206581994|pdb|3CXZ|A Chain A, Crystal Structure Of Cytochrome... 797 0.0 gi|206581993|pdb|3CXY|A Chain A, Crystal Structure Of The Cytoch... 796 0.0 gi|340627282|ref|YP_004745734.1| cytochrome P450 121 CYP121 [Myc... 795 0.0 gi|294993510|ref|ZP_06799201.1| cytochrome P450 121 CYP121 [Myco... 780 0.0 gi|167968223|ref|ZP_02550500.1| cytochrome P450 121 cyp121 [Myco... 698 0.0 gi|289750877|ref|ZP_06510255.1| LOW QUALITY PROTEIN: cytochrome ... 697 0.0 gi|289758401|ref|ZP_06517779.1| LOW QUALITY PROTEIN: cytochrome ... 530 1e-148 gi|328881913|emb|CCA55152.1| putative cytochrome P450 hydroxylas... 476 2e-132 gi|4731332|gb|AAD28449.1|AF127374_4 cytochrome P450 hydroxylase ... 199 5e-49 gi|45124724|emb|CAE53712.1| putative cytochrome P450 [Streptomyc... 194 2e-47 gi|154623231|emb|CAM34359.1| putative cytochrome P450 dependend ... 192 7e-47 gi|337769605|emb|CCB78318.1| Cytochrome P450 107B1 [Streptomyces... 190 3e-46 gi|294633997|ref|ZP_06712553.1| conserved hypothetical protein [... 189 7e-46 gi|2580451|dbj|BAA23153.1| unnamed protein product [Actinomadura... 185 1e-44 gi|303644|dbj|BAA03672.1| P-450-like protein [Micromonospora gri... 182 7e-44 gi|26541527|gb|AAN85514.1|AF484556_36 cytochrome P450 hydroxylas... 182 1e-43 gi|157384619|gb|ABV49597.1| cytochrome P450 [Streptomyces euryth... 179 6e-43 gi|254385127|ref|ZP_05000460.1| cytochrome P-450 [Streptomyces s... 178 1e-42 gi|256378615|ref|YP_003102275.1| cytochrome P450 [Actinosynnema ... 177 2e-42 gi|344998087|ref|YP_004800941.1| cytochrome P450 [Streptomyces s... 177 3e-42 gi|302529558|ref|ZP_07281900.1| cytochrome P450 [Streptomyces sp... 175 1e-41 gi|80279143|gb|ABB52528.1| cytochrome P-450 [Streptomyces sp. KC... 175 2e-41 gi|238064165|ref|ZP_04608874.1| cytochrome P450 [Micromonospora ... 174 2e-41 gi|302527698|ref|ZP_07280040.1| cytochrome P450 [Streptomyces sp... 172 8e-41 gi|112791729|gb|ABI22127.1| cytochrome P450 hydroxylase [Strepto... 172 8e-41 gi|182440582|ref|YP_001828301.1| putative cytochrome P450 [Strep... 172 1e-40 gi|326781255|ref|ZP_08240520.1| Linalool 8-monooxygenase [Strept... 172 1e-40 gi|45934782|gb|AAS79446.1| P450 [Streptomyces bikiniensis] 171 1e-40 gi|271966572|ref|YP_003340768.1| cytochrome P450, nitric oxide r... 171 2e-40 gi|297162535|gb|ADI12247.1| cytochrome P450-like enzyme [Strepto... 171 2e-40 gi|254385126|ref|ZP_05000459.1| cytochrome P-450 [Streptomyces s... 170 3e-40 gi|300787492|ref|YP_003767783.1| cytochrome P450 [Amycolatopsis ... 170 4e-40 gi|324997918|ref|ZP_08119030.1| cytochrome P450 hydroxylase [Pse... 169 8e-40 gi|302547788|ref|ZP_07300130.1| cytochrome P450 107B1 (P450CVIIB... 169 1e-39 gi|29827712|ref|NP_822346.1| cytochrome P450 [Streptomyces averm... 168 1e-39 gi|134098012|ref|YP_001103673.1| cytochrome P450-like enzyme [Sa... 167 2e-39 gi|256376814|ref|YP_003100474.1| cytochrome P450 [Actinosynnema ... 167 2e-39 gi|310817536|ref|YP_003949894.1| cytochrome p450, b class [Stigm... 167 3e-39 gi|115379072|ref|ZP_01466198.1| cytochrome P450 107B1 [Stigmatel... 167 3e-39 gi|80279144|gb|ABB52529.1| cytochrome P-450 [Streptomyces sp. KC... 167 4e-39 gi|224969342|gb|ACN71221.1| cytochrome P450 monooxygenase [Actin... 166 4e-39 gi|325929638|gb|ADZ45320.1| cytochrome P450 [Streptomyces sp. NR... 166 6e-39 gi|254393795|ref|ZP_05008910.1| NocL [Streptomyces clavuligerus ... 166 9e-39 gi|256375333|ref|YP_003098993.1| cytochrome P450 [Actinosynnema ... 165 2e-38 >gi|15609413|ref|NP_216792.1| cytochrome P450 121 CYP121 [Mycobacterium tuberculosis H37Rv] gi|15841769|ref|NP_336806.1| P450 heme-thiolate protein [Mycobacterium tuberculosis CDC1551] gi|31793455|ref|NP_855948.1| cytochrome P450 121 CYP121 [Mycobacterium bovis AF2122/97] 77 more sequence titles Length=396 Score = 800 bits (2066), Expect = 0.0, Method: Compositional matrix adjust. Identities = 396/396 (100%), Positives = 396/396 (100%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|206581996|pdb|3CY1|A Chain A, Crystal Structure Of The Cytochrome P450 Cyp121 S279a Mutant From M. Tuberculosis Length=396 Score = 798 bits (2062), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 396/396 (100%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINL+FADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLAFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|206581995|pdb|3CY0|A Chain A, Crystal Structure Of Cytochrome P450 Cyp121 S237a Mutant From Mycobacterium Tuberculosis Length=396 Score = 798 bits (2062), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 396/396 (100%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVI+TGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVIATGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|206581991|pdb|3CXV|A Chain A, Crystal Structure Of The Cytochrome P450 Cyp121 A233g Mutant From Mycobacterium Tuberculosis Length=396 Score = 798 bits (2061), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 395/396 (99%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFG GVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGGGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|289745551|ref|ZP_06504929.1| cytochrome p450 121 cyp121 [Mycobacterium tuberculosis 02_1987] gi|298525765|ref|ZP_07013174.1| P450 heme-thiolate protein [Mycobacterium tuberculosis 94_M4241A] gi|289686079|gb|EFD53567.1| cytochrome p450 121 cyp121 [Mycobacterium tuberculosis 02_1987] gi|298495559|gb|EFI30853.1| P450 heme-thiolate protein [Mycobacterium tuberculosis 94_M4241A] gi|326903891|gb|EGE50824.1| cytochrome P450 121 cyp121 [Mycobacterium tuberculosis W-148] gi|339295188|gb|AEJ47299.1| cytochrome P450 121 cyp121 [Mycobacterium tuberculosis CCDC5079] gi|339298808|gb|AEJ50918.1| cytochrome P450 121 cyp121 [Mycobacterium tuberculosis CCDC5180] Length=396 Score = 798 bits (2061), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 396/396 (100%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPE+FPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEYFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|206581992|pdb|3CXX|A Chain A, Crystal Structure Of Cytochrome P450 Cyp121 F338h From M. Tuberculosis Length=396 Score = 798 bits (2060), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 395/396 (99%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLA GRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAHGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|206581994|pdb|3CXZ|A Chain A, Crystal Structure Of Cytochrome P450 Cyp121 R386l Mutant From M. Tuberculosis Length=396 Score = 797 bits (2058), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 395/396 (99%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQ RIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQLRIPERLPVLW 396 >gi|206581993|pdb|3CXY|A Chain A, Crystal Structure Of The Cytochrome P450 Cyp121 P346l Mutant From M. Tuberculosis Length=396 Score = 796 bits (2057), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/396 (99%), Positives = 395/396 (99%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFC GSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCLGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|340627282|ref|YP_004745734.1| cytochrome P450 121 CYP121 [Mycobacterium canettii CIPT 140010059] gi|340005472|emb|CCC44632.1| cytochrome P450 121 CYP121 [Mycobacterium canettii CIPT 140010059] Length=396 Score = 795 bits (2054), Expect = 0.0, Method: Compositional matrix adjust. Identities = 394/396 (99%), Positives = 394/396 (99%), Gaps = 0/396 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGEL RLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELGRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ALLKKMP VDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 361 ALLKKMPDVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 >gi|294993510|ref|ZP_06799201.1| cytochrome P450 121 CYP121 [Mycobacterium tuberculosis 210] Length=430 Score = 780 bits (2013), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/389 (99%), Positives = 388/389 (99%), Gaps = 0/389 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 KGELVLVLLEGANFDPE+FPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE Sbjct 301 KGELVLVLLEGANFDPEYFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIP 389 ALLKKMPGVDLAVPIDQLVWRTRFQRR P Sbjct 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRHP 389 >gi|167968223|ref|ZP_02550500.1| cytochrome P450 121 cyp121 [Mycobacterium tuberculosis H37Ra] Length=349 Score = 698 bits (1801), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/346 (99%), Positives = 345/346 (99%), Gaps = 0/346 (0%) Query 51 CTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLE 110 TQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLE Sbjct 4 ATQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLE 63 Query 111 QFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMS 170 QFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMS Sbjct 64 QFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMS 123 Query 171 SADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTF 230 SADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTF Sbjct 124 SADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTF 183 Query 231 FGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATA 290 FGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATA Sbjct 184 FGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATA 243 Query 291 DIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSAL 350 DIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSAL Sbjct 244 DIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSAL 303 Query 351 GRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 GRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Sbjct 304 GRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 349 >gi|289750877|ref|ZP_06510255.1| LOW QUALITY PROTEIN: cytochrome P450 121 cyp121 [Mycobacterium tuberculosis T92] gi|289691464|gb|EFD58893.1| LOW QUALITY PROTEIN: cytochrome P450 121 cyp121 [Mycobacterium tuberculosis T92] Length=397 Score = 697 bits (1798), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/346 (100%), Positives = 346/346 (100%), Gaps = 0/346 (0%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF Sbjct 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL Sbjct 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL 120 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI Sbjct 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI 180 Query 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS Sbjct 181 NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS 240 Query 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR Sbjct 241 FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR 300 Query 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCP 346 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCP Sbjct 301 KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCP 346 >gi|289758401|ref|ZP_06517779.1| LOW QUALITY PROTEIN: cytochrome P450 121 cyp121 [Mycobacterium tuberculosis T85] gi|289713965|gb|EFD77977.1| LOW QUALITY PROTEIN: cytochrome P450 121 cyp121 [Mycobacterium tuberculosis T85] Length=272 Score = 530 bits (1366), Expect = 1e-148, Method: Compositional matrix adjust. Identities = 260/262 (99%), Positives = 261/262 (99%), Gaps = 0/262 (0%) Query 135 NDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILE 194 DFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILE Sbjct 11 KDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILE 70 Query 195 NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ 254 NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ Sbjct 71 NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ 130 Query 255 LRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANF 314 LRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANF Sbjct 131 LRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANF 190 Query 315 DPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVP 374 DPE+FPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVP Sbjct 191 DPEYFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVP 250 Query 375 IDQLVWRTRFQRRIPERLPVLW 396 IDQLVWRTRFQRRIPERLPVLW Sbjct 251 IDQLVWRTRFQRRIPERLPVLW 272 >gi|328881913|emb|CCA55152.1| putative cytochrome P450 hydroxylase [Streptomyces venezuelae ATCC 10712] Length=397 Score = 476 bits (1226), Expect = 2e-132, Method: Compositional matrix adjust. Identities = 232/388 (60%), Positives = 295/388 (77%), Gaps = 3/388 (0%) Query 10 PFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAG 69 PF G R+P V LR EP+R+VRTI GAEAWLVSSY LC QVLED RFS+K+T+A G Sbjct 12 PFDWDGTRLPAEVEALRA-EPVRRVRTIAGAEAWLVSSYELCRQVLEDPRFSLKDTSAPG 70 Query 70 APRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLITEGA 129 APR ALT+PP VVNNMGNI AGLRKAVMKAI PKAPGLE++LR A +L+D L+ EGA Sbjct 71 APRQYALTIPPHVVNNMGNITGAGLRKAVMKAINPKAPGLEEWLRARAGALVDALVAEGA 130 Query 130 PADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYM 189 P +LR +ADP ++ LHC++LGIP+EDGP+L RSL +AFM++ I AA+++WDRDI YM Sbjct 131 PGELRGAYADPYSSGLHCRMLGIPEEDGPRLLRSLDVAFMNAPSEIEAARLHWDRDIAYM 190 Query 190 AGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISL 249 L++P T GLM EL+ LR+DP Y+H++DE+ AT+GVT FGAGVIST FLT AL+S+ Sbjct 191 TERLDDP-ATGGLMAELAALREDPEYAHLTDEMLATVGVTLFGAGVISTAGFLTMALVSV 249 Query 250 IQRPQLR-NLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVL 308 + RP +R L + ++ELLR+NLS DGLPRLA D+++GDV VR GELVLVL Sbjct 250 LTRPDVRAALTAGGGHGVAGAMDELLRVNLSIGDGLPRLALEDVRLGDVEVRAGELVLVL 309 Query 309 LEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPG 368 +E AN DP HFP+P + DR N HL+FG G+H+CP +ALG+RHA+I +E LL ++P Sbjct 310 VEAANHDPLHFPDPLAFRPDRENAADHLSFGGGRHYCPATALGKRHAEIALETLLDRLPE 369 Query 369 VDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + LAVP++QLVWRT F +R+PERLPV W Sbjct 370 LRLAVPVEQLVWRTNFMKRLPERLPVAW 397 >gi|4731332|gb|AAD28449.1|AF127374_4 cytochrome P450 hydroxylase [Streptomyces lavendulae] Length=410 Score = 199 bits (507), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 138/394 (36%), Positives = 200/394 (51%), Gaps = 12/394 (3%) Query 10 PFSARGDRIPDAVAE-LRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PF A PD E LR P+++V G EAWL + Y V DRRFS + A Sbjct 22 PFHAPDRLEPDPYWEPLRRERPLQRVTLPYGGEAWLATRYQDVRAVFADRRFSRQLAVAP 81 Query 69 GAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITP-KAPGLEQFLRDTANSLLDNLITE 127 GAPR PP+ V ++ A LR+ V K TP + + ++ TA+ LLD + Sbjct 82 GAPRFLPHQPPPDAVLSVEGPDHARLRRLVGKVFTPRRVEDMRPLIQRTADGLLDAMEEM 141 Query 128 GAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDI- 186 G PADL DF+ P A ++ C++LG+P ED K F S A +++ PA ++ + Sbjct 142 GPPADLVEDFSLPFAVSMICELLGVPPEDR-KRFCVWSDALLTTTAHTPAQVRDYMMQMH 200 Query 187 EYMAGILENPNI--TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTT 244 +Y+ G++ + T L+G L R + +++ + AG ++ S + Sbjct 201 DYLGGLVAQRRVRPTADLIGSLVTARDE--EDKLTEGELVRLAEAILIAGYETSASQIPN 258 Query 245 ALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGE 303 L L + PQL + +LIP VEELLR + + DG PR AT D+++G VLVR GE Sbjct 259 FLYVLFRHPQLLERIRNDHDLIPDAVEELLRFVPIGTVDGFPRTATEDVELGGVLVRAGE 318 Query 304 LVLVLLEGANFDPEHFPNPGSIEL-DRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEAL 362 V+ + AN DPE F +P ++L RPNP HL FG G H C G+ L R QI + L Sbjct 319 TVVPSMGAANRDPELFTDPDELDLARRPNP--HLGFGAGPHHCLGAQLARVELQITLTTL 376 Query 363 LKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ++ P + LAVP + L W+ R +PV W Sbjct 377 FRRYPRLRLAVPEESLSWKEGLMVRGMHTMPVTW 410 >gi|45124724|emb|CAE53712.1| putative cytochrome P450 [Streptomyces peucetius ATCC 27952] Length=414 Score = 194 bits (494), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 133/393 (34%), Positives = 198/393 (51%), Gaps = 10/393 (2%) Query 10 PFSARGDRIPDAVAE-LRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PF + PD E LR +P+++V G EAWL + Y +V DRRFS A Sbjct 26 PFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAWLATRYQDVRKVFADRRFSRALAVAP 85 Query 69 GAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITE 127 GAPR P + V ++ A LR+ V K TP+ + ++ TA+ LLD + Sbjct 86 GAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFTPRRVEAMRPLIQSTADRLLDAMEEI 145 Query 128 GAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPA-AKINWDRDI 186 G PADL DF+ P A ++ C++LG+P ED K F + S A +++ PA + + + Sbjct 146 GPPADLVEDFSLPFAVSMICELLGVPPEDR-KRFCTWSDALLTTTAHTPAQVRDHMMQMH 204 Query 187 EYMAGILENPNI--TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTT 244 +Y+ G++ T L+G L R A +++ + AG ++ S + Sbjct 205 DYLGGLVAQRRTRPTEDLIGSLVTARD--AEDKLTEGELVRLAEAILIAGYETSASQIPN 262 Query 245 ALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGE 303 L L + P L L +LIP VEELLR + + DG PR AT D+++G VL+R GE Sbjct 263 FLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTVDGFPRTATEDVELGGVLIRAGE 322 Query 304 LVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALL 363 V+ + AN DPE F +P ++L R +P HL FG G H C G+ L R QI + L Sbjct 323 TVVPSMGAANRDPELFADPEELDLTR-SPNPHLGFGAGPHHCLGAQLARVELQITLTTLF 381 Query 364 KKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 ++ P + LAVP + L W+ R +P+ W Sbjct 382 RRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW 414 >gi|154623231|emb|CAM34359.1| putative cytochrome P450 dependend monoxygenase [Streptomyces tendae] Length=399 Score = 192 bits (489), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 132/386 (35%), Positives = 202/386 (53%), Gaps = 15/386 (3%) Query 19 PDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTV 78 PD A L EP+ +VR TG + WLV+ + +VL D RFS + A GAPRL + Sbjct 21 PDECAALLREEPVARVRIPTGDQVWLVTRHEDVRRVLSDTRFSREAITAPGAPRLLPIAE 80 Query 79 PPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDF 137 + + M + LR+ V +A +P+ L + +R A L+D ++ +G PADL Sbjct 81 GSKSIFVMDPPEHSRLRRLVSRAFSPRRIESLREDVRQLAEDLVDAMVDQGPPADLIAGL 140 Query 138 ADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSA----DPIPAAKINWDRDIEYMAGIL 193 A PL + C++LG+P ED + FR + +S A + + AA+ D Y+ ++ Sbjct 141 AQPLPITVICRMLGVPYEDVER-FREWTDVMLSYARDGREQVAAAR---DSLSGYLTELI 196 Query 194 E--NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQ 251 + + T L+ L D + D G T GAG +T + L AL++L++ Sbjct 197 DAKRAHPTDDLLMVLITAADD--GDRLDDAELLAFGYTLLGAGYHATTAGLVHALLALVR 254 Query 252 RPQLRNLLHEKPELIPAGVEELLRINLSFAD-GLPRLATADIQVGDVLVRKGELVLVLLE 310 RP L ++PEL+P V+ELLR + + + G R+A D+++ V + G+ VL + Sbjct 255 RPADLAALRDRPELMPTAVDELLRRSQAGSGLGAMRIALEDVEIHGVRIAAGDAVLPWIN 314 Query 311 GANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVD 370 AN DP F +P + LDR P +HL+FG G H C G+ LGR +I + ALL++MPG+ Sbjct 315 AANRDPRVFDDPDGLLLDR-KPNAHLSFGHGIHHCLGAQLGRMELEIALGALLRRMPGLR 373 Query 371 LAVPIDQLVWRTRFQRRIPERLPVLW 396 LAVP L W ++ P LPV W Sbjct 374 LAVPEADLQWSSQLAFSRPRTLPVAW 399 >gi|337769605|emb|CCB78318.1| Cytochrome P450 107B1 [Streptomyces cattleya NRRL 8057] Length=404 Score = 190 bits (483), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 139/398 (35%), Positives = 211/398 (54%), Gaps = 24/398 (6%) Query 10 PFS-ARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PF+ A G + DA E R + + +VR G AWL + YA VL DRRFS E A Sbjct 20 PFNEADGISLADAYEEAREQPGLLRVRMAYGEPAWLATRYADARLVLGDRRFSRAEGARH 79 Query 69 GAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAIT-PKAPGLEQFLRDTANSLLDNLITE 127 PR + +++ M LR V KA T + L +R+ A+ L+D ++ Sbjct 80 DEPRQSEGRRDSGILS-MDPPDHTRLRTLVAKAFTMHQVEKLRPAVRELADELIDKMVAT 138 Query 128 GAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRD-- 185 GAP DL +FA P+ + C++LG+P ED P+ FR+ S A +S++ + A + + +++ Sbjct 139 GAPVDLVEEFALPVPVGVICQLLGVPVEDRPR-FRAWSDAALSTSS-LTAEEFDANQEEL 196 Query 186 IEYMAGILEN------PNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTG 239 YM G++E+ ++ TGL+ +R R D ++++ + V AG +T Sbjct 197 RAYMRGLIEDHRARPREDLITGLIE--ARDRDD----RLTEQELVDLCVGILVAGHETTA 250 Query 240 SFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVL 298 + + +++L+ RP+ N L E PEL+P VEEL+R + L PR AT D++VG L Sbjct 251 TQIPNFVVTLLDRPEQWNRLREDPELVPTAVEELMRFVPLGSGASFPRYATEDVEVGGTL 310 Query 299 VRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIG 358 VR GE VLV + AN DP F P ++L R HL FG G H C G+ L R Q Sbjct 311 VRAGEPVLVAVGAANRDPARFDAPQELDLAREG-NQHLGFGHGVHHCLGAPLARLELQEA 369 Query 359 IEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + ALL+++PG+ +A I+ W+T+ R P LPV W Sbjct 370 LGALLRRLPGLRIAGDIE---WKTQMLVRGPRTLPVGW 404 >gi|294633997|ref|ZP_06712553.1| conserved hypothetical protein [Streptomyces sp. e14] gi|292829993|gb|EFF88346.1| conserved hypothetical protein [Streptomyces sp. e14] Length=398 Score = 189 bits (480), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 140/386 (37%), Positives = 198/386 (52%), Gaps = 24/386 (6%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 AELR P+ +VR G +AWLV+ YA QVL D RFS+K PR+ L++ Sbjct 25 AELRA-GPMPRVRLPYGEDAWLVTGYADARQVLSDPRFSLKAGVDRDQPRVRPLSI---- 79 Query 83 VNNMGNIADAGLRKAVMKAITPK---APGLEQF---LRDTANSLLDNLITEGAPADLRND 136 + +G ++ G A ++ + + A +EQ + + A LLD L G P DL D Sbjct 80 -SGVGLLSTDGAEHARLRGVVARHFSARRVEQLRGRVCEIAGELLDRLEENGPPGDLVQD 138 Query 137 FADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENP 196 FA PLA L C +LG+P D ++ R L + + + DR + + E Sbjct 139 FAFPLAITLICDLLGVPDGDHHRIRRWLEVMLAHTV----TVEDFTDRSAAFGGYLTELV 194 Query 197 NITTGLMGE--LSRLRK--DPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQR 252 + G+ L+RL + D DELF + AG I+T + ++ L++R Sbjct 195 ELRRREPGDDLLTRLVRAHDEEGRLTHDELF-ELTAELLSAGFITTYNQISNFCHLLLRR 253 Query 253 PQLRNLLHEKPELIPAGVEELLRINLSFADGL--PRLATADIQVGDVLVRKGELVLVLLE 310 PQ + L + P+ IPA VEELLR + +GL PR AT D++VG VLVR GE VLV + Sbjct 254 PQWLSRLRDHPDGIPAAVEELLRY-VPMPNGLTFPRYATEDVEVGGVLVRAGEPVLVDMS 312 Query 311 GANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVD 370 AN DP + + S+ LDR HL+FG G HFC G+ L R Q+ +E LL +MPG+ Sbjct 313 AANRDPAVYHDAESLVLDRVPQAPHLSFGHGAHFCVGAPLARLELQVALETLLTRMPGLK 372 Query 371 LAVPIDQLVWRTRFQRRIPERLPVLW 396 AVP +L W+T R LPV W Sbjct 373 PAVPDSELRWKTEAMLRGLHALPVDW 398 >gi|2580451|dbj|BAA23153.1| unnamed protein product [Actinomadura hibisca] gi|120431575|gb|ABM21756.1| PdmJ [Actinomadura hibisca] Length=411 Score = 185 bits (470), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 130/384 (34%), Positives = 191/384 (50%), Gaps = 17/384 (4%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 A LR +P+ KV TG AW+V+ YA V DRRFS + GAPRL + + Sbjct 35 ARLRASDPVAKVVLPTGDHAWVVTRYADVRFVTSDRRFSKEAVTRPGAPRLIPMQRGSKS 94 Query 83 VNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDFADPL 141 + M +RK V +A T + G+ +RD + +D ++ G PADL A PL Sbjct 95 LVIMDPPEHTRMRKIVSRAFTARRVEGMRAHVRDLTSGFVDEMVEHGPPADLIAHLALPL 154 Query 142 ATALHCKVLGIPQEDGPKLF----RSLSIAF--MSSADPIPAAKINWDRDIEYMAGILEN 195 + C++LG+P ED P+ R L+I ++ AD I AA R Y+A +++ Sbjct 155 PVTVICEMLGVPPEDRPRFQDWTDRMLTIGAPALAQADEIKAAV---GRLRGYLAELIDA 211 Query 196 PNITTG--LMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRP 253 L+ LSR D +S+E T G+T AG +T + +T ++ L++ P Sbjct 212 KTAAPADDLLSLLSRAHAD---DGLSEEELLTFGMTLLAAGYHTTTAAITHSVYHLLREP 268 Query 254 QLRNLLHEKPELIPAGVEELLRINLSFADGLP-RLATADIQVGDVLVRKGELVLVLLEGA 312 L E P IPA VEELLR R+A D++VG LVR GE V+ L A Sbjct 269 SRYARLREDPSGIPAAVEELLRYGQIGGGAGAIRIAVEDVEVGGTLVRAGEAVIPLFNAA 328 Query 313 NFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLA 372 N DPE F +P ++L R + H+A G G H+C G+ L R Q+ +E L+++ P + LA Sbjct 329 NRDPEVFADPEELDLGRTD-NPHIALGHGIHYCLGAPLARLELQVVLETLVERTPALRLA 387 Query 373 VPIDQLVWRTRFQRRIPERLPVLW 396 + + WR P+ LP+ W Sbjct 388 IDDADITWRPGLAFARPDALPIAW 411 >gi|303644|dbj|BAA03672.1| P-450-like protein [Micromonospora griseorubida] Length=397 Score = 182 bits (463), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 130/384 (34%), Positives = 192/384 (50%), Gaps = 20/384 (5%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 EL+ EP+ +VR G EAWLV+ Y VL D RF + PR PE+ Sbjct 24 GELQETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPRTR-----PEM 78 Query 83 VN----NMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDF 137 V +M + LR+ V+KA T + A L R+ A+ L+D + G PADL F Sbjct 79 VKGGLLSMDPPEHSRLRRLVVKAFTARRAESLRPRAREIAHELVDQMAATGQPADLVAMF 138 Query 138 ADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINW--DRDIEYMAGILEN 195 A L + C++LG+P D + F S AF+S+A+ + A ++ ++ YM +++ Sbjct 139 ARQLPVRVICELLGVPSADHDR-FTRWSGAFLSTAE-VTAEEMQEAAEQAYAYMGDLIDR 196 Query 196 --PNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRP 253 T L+ L + R +S++ + + AG ST + + + L+ RP Sbjct 197 RRKEPTDDLVSALVQARDQ--QDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRP 254 Query 254 QLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGA 312 +LR L ++PELIP+ VEEL R + L PR A D+ + V +R GE VL A Sbjct 255 ELRRQLLDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAA 314 Query 313 NFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLA 372 N D FP+ I++DR P HL FG G H C G+ L R Q+ +E LL+++PG+ L Sbjct 315 NRDQAQFPDADRIDVDR-TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLG 373 Query 373 VPIDQLVWRTRFQRRIPERLPVLW 396 +P QL W R P LPV+W Sbjct 374 IPETQLRWSEGMLLRGPLELPVVW 397 >gi|26541527|gb|AAN85514.1|AF484556_36 cytochrome P450 hydroxylase [Streptomyces atroolivaceus] Length=399 Score = 182 bits (461), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 133/405 (33%), Positives = 201/405 (50%), Gaps = 15/405 (3%) Query 1 MTATVLLEV-PFSARGD--RIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLED 57 M+AT + + PF D I AELR +P+ +VR G E W+V+ Y D Sbjct 1 MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGEGWMVTRYDDVRAANSD 60 Query 58 RRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPG-LEQFLRDT 116 RFS + PR L + + ++ LR+ + KA T + G ++ +L + Sbjct 61 PRFSRAQIGE-DTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEEL 119 Query 117 ANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIP 176 LLD + G PAD+ D A P A+ C++LG+P ED + F+ S MS+ Sbjct 120 FAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDRGR-FQHWSEVIMSTTAYSK 178 Query 177 AAKINWDRDIE-YMAGILENPNIT--TGLMGELSRLRKDPAYSHVSDELFATIGVTFFGA 233 ++ D I Y+A ++ L+G L R D ++++ T GVT A Sbjct 179 EEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD--DRLTEDELITFGVTLLVA 236 Query 234 GVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADI 292 G ++ L + +L+ +LL E+PEL+P VEELLR + L G R+A D+ Sbjct 237 GHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEELLRFVPLGNGVGNARIALEDV 296 Query 293 QVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALG 351 ++ VR GE V+ AN DP F +P +++ R NP HLAFG G H+C G+ L Sbjct 297 ELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNP--HLAFGHGAHYCLGAQLA 354 Query 352 RRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 R ++ I LL++ PG+ LAVP DQ+ W+T R P+RLP+ W Sbjct 355 RMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 399 >gi|157384619|gb|ABV49597.1| cytochrome P450 [Streptomyces eurythermus] Length=415 Score = 179 bits (455), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 131/395 (34%), Positives = 194/395 (50%), Gaps = 15/395 (3%) Query 10 PFS-ARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PFS A G + LR REP+ +VR G EAW+V+ +A VL D RFSM A Sbjct 28 PFSTATGLGMDPLYGYLREREPVARVRMPYGGEAWMVTRHADAKLVLGDPRFSMAAGAGK 87 Query 69 GAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITE 127 PR + P + M LR+ T + + + A+ L+D + Sbjct 88 DVPRPTEQLLEPGGLVAMDPPEHTRLRRLAGGVFTHRRVERMRPSVTALAHRLVDGMSAA 147 Query 128 GAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIE 187 G+ ADL A P++ + C++LG+ ED +F+ S A +S+A P + + + Sbjct 148 GSSADLLEAVALPVSIGVICELLGVDYED-RHVFQRFSDALLSTALPPEEVRRAGEEFVG 206 Query 188 YMAGIL----ENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLT 243 Y+A ++ E+P T L+G + + R D +S+ +G G +T + + Sbjct 207 YLARLVAERRESP--TDDLLGAMVQARDDE--DRLSENELYMLGAGLLVGGYETTATQIG 262 Query 244 TALISLIQRPQLRNLLHEKPELIPAGVEELLRIN-LSFADGLPRLATADIQVGDVLVRKG 302 L++ +L L E P LI VEELLR L+ DG R+A D+ VG L+R G Sbjct 263 NFAYLLLRDRRLYASLVEDPGLIQGAVEELLRFTPLTTVDGYARIALEDVMVGGTLIRAG 322 Query 303 ELVLVLLEGANFDPEHFPNPGSIELDRP-NPTSHLAFGRGQHFCPGSALGRRHAQIGIEA 361 E V + AN DPE FP P ++ R NP HL FG G H+C G+ L R Q+ +E Sbjct 323 EAVFTSVAAANLDPEVFPGPERLDFTRERNP--HLGFGHGIHYCMGAPLARLEIQVVLEV 380 Query 362 LLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 L +++PG+ LAVP + W+ R+PERLPV W Sbjct 381 LTRRLPGLRLAVPAADVRWQPGLLLRVPERLPVTW 415 >gi|254385127|ref|ZP_05000460.1| cytochrome P-450 [Streptomyces sp. Mg1] gi|194344005|gb|EDX24971.1| cytochrome P-450 [Streptomyces sp. Mg1] Length=407 Score = 178 bits (452), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 130/409 (32%), Positives = 203/409 (50%), Gaps = 42/409 (10%) Query 10 PFSARGDRIPDAVA------ELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMK 63 PFS +P+ +A LR EP+ ++R G EAWL++ +A VL D RFSM+ Sbjct 14 PFS-----LPEGIALDPLYSHLREHEPVSRIRMPYGGEAWLLTRHADVKAVLGDPRFSME 68 Query 64 ETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKA-----PGLEQFLRDTAN 118 A PR +P + +M LR+ KA T + P + +F + Sbjct 69 AGAGRDVPRPTEYPLPAGGLISMDPPGHTRLRRLAGKAFTARRVEELRPQVSRF----TH 124 Query 119 SLLDNLITEGAPA-DLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSA-DPIP 176 LLD ++ P+ ++ D A P++ ++ C++LG+ ED LFR+ S A +SS+ P Sbjct 125 ELLDGMVARDEPSGEIMEDLALPVSISVICRLLGVSYEDR-HLFRNFSEALVSSSLGPAE 183 Query 177 AAKINWDRDIEYMAGILENPNI--TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAG 234 ++ D YMA ++ + T + + + R + D+ + + GAG Sbjct 184 LQRVTEDF-TAYMAELVADRRARPTDDFLSTMVQARDE-------DDRLSEAELLMLGAG 235 Query 235 VISTGSFLTTALIS-----LIQRPQLRNLLHEKPELIPAGVEELLRIN-LSFADGLPRLA 288 ++ +G T I L+ +L L P+L+PA VEELLR LS DG R+A Sbjct 236 LLISGYETTATQIGNFVHLLLDDRRLYERLVADPDLVPAAVEELLRFTPLSTTDGFARIA 295 Query 289 TADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRP-NPTSHLAFGRGQHFCPG 347 D+++G L+R GE V+ + AN D FP S++ R NP HL FG G H+C G Sbjct 296 LEDVEIGGTLIRAGEAVITSIASANLDDTAFPGAASLDFTRAQNP--HLGFGHGAHYCMG 353 Query 348 SALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + L R Q+ + L++++PG+ L+VP +L WRT R PE +PV W Sbjct 354 APLARLELQVVLSTLVERLPGLRLSVPASELRWRTGSLMRTPEAVPVTW 402 >gi|256378615|ref|YP_003102275.1| cytochrome P450 [Actinosynnema mirum DSM 43827] gi|47078304|gb|AAT09797.1| NocL [Nocardia uniformis subsp. tsuyamanensis] gi|255922918|gb|ACU38429.1| cytochrome P450 [Actinosynnema mirum DSM 43827] Length=398 Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 133/386 (35%), Positives = 190/386 (50%), Gaps = 23/386 (5%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAA-AGAPRLNALTVPPE 81 A LR +P +VR G + WLV+ + VL D RFS A PR+ P Sbjct 24 APLRAEQPALRVRLPYGEDCWLVTRHEDVKAVLSDSRFSRARAAGREETPRVTPEAAPAG 83 Query 82 VVNNMGNIADAGLRKAVMKAITPKAPGLEQF---LRDTANSLLDNLITEGAPADLRNDFA 138 + +M + LRK + +A T + + +F ++ + LLD + GAPADL A Sbjct 84 SMLSMDPPEHSRLRKLIARAFTSRR--VREFRPRTQEIVDGLLDQVEQAGAPADLVAGLA 141 Query 139 DPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSA----DPIPAAKINWDRDIEYMAGILE 194 PL ++ ++LG+P ED + FR S +S+ + I AA+ + EY+ + + Sbjct 142 LPLPVSVISQMLGVPTEDHYR-FRDFSATVLSTTAHTREEIVAARAALE---EYLGELAD 197 Query 195 NPNITTG--LMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQR 252 G LM L D ++D G+T G ST S ++ L++R Sbjct 198 QRRREPGEDLMSALVAAHDD---DRLTDRELTQTGITLLVGGHESTASQFACSVYLLLER 254 Query 253 PQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEG 311 P+ LL + PEL+P VEELLR I L R+AT D++VG VLVR GE V+ Sbjct 255 PERWALLRDNPELVPTAVEELLRFIPLGSGGAFARIATEDVEVGGVLVRAGEAVVASTNS 314 Query 312 ANFDPEHFPNPGSIELDRP-NPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVD 370 AN D F +P ++L R NP HLAFG G H C G+ L R Q+ + +LL + PG+ Sbjct 315 ANRDDRVFTDPDVLDLAREHNP--HLAFGGGVHVCLGAQLARGELQVALTSLLTRFPGLR 372 Query 371 LAVPIDQLVWRTRFQRRIPERLPVLW 396 LAVP +Q+ WR R P LPV W Sbjct 373 LAVPPEQVPWRQGSLLRSPVELPVTW 398 >gi|344998087|ref|YP_004800941.1| cytochrome P450 [Streptomyces sp. SirexAA-E] gi|344313713|gb|AEN08401.1| cytochrome P450 [Streptomyces sp. SirexAA-E] Length=397 Score = 177 bits (448), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 132/374 (36%), Positives = 188/374 (51%), Gaps = 23/374 (6%) Query 33 KVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADA 92 +VR G AWL + YA VL DRRFS E PR + +++ M Sbjct 37 RVRLAYGEPAWLATRYADARLVLGDRRFSRAEALRHDTPRQSEGRQDSGILS-MDPPGHT 95 Query 93 GLRKAVMKAIT-PKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLG 151 LR V KA T + L ++R+ + LLD L G PADL +A P+ A+ C++LG Sbjct 96 RLRTLVAKAFTVHQVEKLRPWVRELSQGLLDELEALGQPADLVEHYALPIPVAVICRMLG 155 Query 152 IPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRD--IEYMAGILEN------PNITTGLM 203 +P+ED PK FR S A +S++ + A + R+ YMAG++E+ P++ TGL Sbjct 156 VPEEDRPK-FRVWSDAALSTSS-LTAEEFRRSREELRAYMAGLIEDHRLRPRPDLMTGL- 212 Query 204 GELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKP 263 + +S+ + V AG +T + + + +L+ P LL E+P Sbjct 213 -----IEARDTGDRLSEAELVDLCVGILVAGHETTATQIPNFVHALLDHPDQMALLRERP 267 Query 264 ELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNP 322 ELI VEELLR + L G R AT D++VG LVR GE VLV + AN D F P Sbjct 268 ELIRGAVEELLRFVPLGSGAGFARYATEDVEVGGTLVRAGEPVLVAIGAANRDALKFDAP 327 Query 323 GSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRT 382 G +++ R HL FG G H C G+ L R Q +EALL + PG+ LA ++ W+T Sbjct 328 GRLDVTRSG-VQHLGFGHGVHHCLGAPLARLELQEALEALLVRFPGLRLAGDVE---WKT 383 Query 383 RFQRRIPERLPVLW 396 + R P +PV W Sbjct 384 QMLVRGPREMPVGW 397 >gi|302529558|ref|ZP_07281900.1| cytochrome P450 [Streptomyces sp. AA4] gi|302438453|gb|EFL10269.1| cytochrome P450 [Streptomyces sp. AA4] Length=398 Score = 175 bits (443), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 129/395 (33%), Positives = 197/395 (50%), Gaps = 15/395 (3%) Query 10 PFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAG 69 PF + + +L+ EP+ +V+ G AWL + YA V D RFS + Sbjct 11 PFDMHETSVSETYHQLQRDEPMSRVQLPFGEPAWLATKYADVKLVTADPRFSRELAQGLD 70 Query 70 APRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKA-PGLEQFLRDTANSLLDNLITEG 128 PR+ + ++ M + LR+ VMKA T + + + +R + L+D +I G Sbjct 71 QPRMRRQQMGDGIMG-MDPPDHSRLRRLVMKAFTARRLEAMRESVRTLVHELIDGMIENG 129 Query 129 APADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPI-PAAKINWDRDIE 187 AP D+ D A PL + C +LG+P+ED +FR + A +S A + D+ Sbjct 130 APGDIVEDLARPLPVTVICNLLGVPKEDH-TIFREWTQALVSDATAKGDVLDVYGDQLDN 188 Query 188 YMAGIL----ENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLT 243 Y+A ++ E+P T L+G L +D +EL + G GV + S L Sbjct 189 YVAKLVAQRREDP--TDDLLGALV-FARDAGDKLSENELISIAGAGLLTGGVETVSSALP 245 Query 244 TALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKG 302 + + +L+ +P+L L +PE++P VEELLR + ++ A R A DI++G V+VR G Sbjct 246 SFVFTLLTQPELLAQLRAQPEIMPTAVEELLRWVPINTAAMFARYAREDIRIGGVVVRAG 305 Query 303 ELVLVLLEGANFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEA 361 + VL L AN DPE F NP I+L R PNP H+AFG G H C G+ L R Q ++A Sbjct 306 DPVLPALHAANRDPEVFANPDVIDLTRSPNP--HVAFGHGAHHCIGAQLARLELQEALKA 363 Query 362 LLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 +L++ P + LA + + W R P L V W Sbjct 364 ILERFPELRLADGREGVKWEYGVIVRGPSLLRVAW 398 >gi|80279143|gb|ABB52528.1| cytochrome P-450 [Streptomyces sp. KCTC 0041BP] Length=407 Score = 175 bits (443), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 128/409 (32%), Positives = 203/409 (50%), Gaps = 42/409 (10%) Query 10 PFSARGDRIPDAVA------ELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMK 63 PFS +P+ +A LR EP+ ++R G EAWL++ +A VL D RFSM+ Sbjct 14 PFS-----LPEGIALDPLYSHLREHEPVSRIRMPYGGEAWLLTRHADVKAVLGDPRFSME 68 Query 64 ETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKA-----PGLEQFLRDTAN 118 A PR +P + +M LR+ KA T + P + +F + Sbjct 69 AGAGRDVPRPTEYPLPAGGLISMDPPGHTRLRRLAGKAFTARRVEELRPQVSRF----TH 124 Query 119 SLLDNLITEGAPA-DLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSA-DPIP 176 LLD ++ P+ ++ D A P++ ++ C++LG+ +D LFR+ S A +SS+ P Sbjct 125 ELLDGMVARDEPSGEIMEDLALPVSISVICRLLGVSYDDR-HLFRNFSEALVSSSLGPAE 183 Query 177 AAKINWDRDIEYMAGILENPNI--TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAG 234 ++ + YMA ++ + T + + + R + D+ + + GAG Sbjct 184 LQRVT-EGFTAYMAELVADRRARPTDDFLSTMVQARDE-------DDRLSEAELLMLGAG 235 Query 235 VISTGSFLTTALIS-----LIQRPQLRNLLHEKPELIPAGVEELLRIN-LSFADGLPRLA 288 ++ +G T I L+ +L L P+L+PA VEELLR LS DG R+A Sbjct 236 LLISGYETTATQIGNFVHLLLDDRRLYERLVADPDLVPAAVEELLRFTPLSTTDGFARIA 295 Query 289 TADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRP-NPTSHLAFGRGQHFCPG 347 D+++G L+R GE V+ + AN D FP S++ R NP HL FG G H+C G Sbjct 296 LEDVEIGGTLIRAGEAVITSIASANLDGTAFPGAASLDFTRAQNP--HLGFGHGAHYCMG 353 Query 348 SALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + L R Q+ + L++++PG+ L+VP +L WRT R PE +PV W Sbjct 354 APLARLELQVVLSTLVERLPGLRLSVPASELRWRTGSLMRTPEAVPVTW 402 >gi|238064165|ref|ZP_04608874.1| cytochrome P450 [Micromonospora sp. ATCC 39149] gi|237885976|gb|EEP74804.1| cytochrome P450 [Micromonospora sp. ATCC 39149] Length=398 Score = 174 bits (441), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 133/379 (36%), Positives = 184/379 (49%), Gaps = 9/379 (2%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 A LR EP+ +V+ G AWL + YA VL D RFS PRL + + Sbjct 24 ATLRRDEPMSRVQLPYGEPAWLATRYADVKVVLTDPRFSRAIAQGLDQPRLRR-QLDGDG 82 Query 83 VNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDFADPL 141 + M LR+ V KA T + + +R+ A L+D ++ +G PADL +FA PL Sbjct 83 IMGMDPPDHTRLRRLVGKAFTARRVEAMRADVRNRARRLVDAMVAKGPPADLVEEFARPL 142 Query 142 ATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINW-DRDIEYMAGIL--ENPNI 198 ++ C +LG+P D ++FR + A D +YMAG++ Sbjct 143 PVSVICDLLGVPFADH-QIFREWTEGLTDDATAKREVFFELGDALGDYMAGLVAQRRREP 201 Query 199 TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNL 258 T L+G L R R D DEL + G GV + S L + + +L+ P+ L Sbjct 202 TDDLLGALVRAR-DNGDKLSEDELISIAGPGLLTGGVETVSSGLPSFVFTLLTHPEQLAL 260 Query 259 LHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPE 317 L PEL+P VEELLR + ++ A R A AD+ GDV+VR G+ VL L N DPE Sbjct 261 LGGSPELMPTAVEELLRFVPINTAAMFARYALADVAFGDVVVRAGDPVLPALAAGNRDPE 320 Query 318 HFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQ 377 F +P I+L R N HLAFG G H C G+ L R Q + LL ++PG+ LA Sbjct 321 VFADPERIDLTRRN-NPHLAFGHGPHHCIGAQLARLELQEALTELLTRLPGLRLAEGRAG 379 Query 378 LVWRTRFQRRIPERLPVLW 396 + W+ R P RLPV W Sbjct 380 VRWKYGVIVRGPARLPVTW 398 >gi|302527698|ref|ZP_07280040.1| cytochrome P450 [Streptomyces sp. AA4] gi|302436593|gb|EFL08409.1| cytochrome P450 [Streptomyces sp. AA4] Length=402 Score = 172 bits (436), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 124/395 (32%), Positives = 189/395 (48%), Gaps = 16/395 (4%) Query 10 PFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAG 69 PF + AE+R ++ + +VR G EAWL + Y VL DRR T Sbjct 9 PFEPSALTVDARYAEMREQQGMSRVRLPFGGEAWLATRYEDVRAVLVDRRLMRSLTVGKD 68 Query 70 APRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEG 128 APR + M + LR+ V A TPK L +++ A+ L+D +I +G Sbjct 69 APRGTEAIESESSIITMDPPTHSRLRRLVAAAFTPKRVETLRPRIQEIADGLIDGMIEQG 128 Query 129 APADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRD--I 186 PADL + F+ PL C++LG+PQED K+ M S + + I + Sbjct 129 PPADLVSSFSIPLPITALCELLGVPQEDRDKVHTWTDTMLMLSGEGLDHTSIMTAQSELW 188 Query 187 EYMAGIL----ENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFL 242 Y+AG++ E P T L+G L R R D +++ + G +T + + Sbjct 189 GYIAGLVAERRETP--TDDLIGALVRARDDEG--RLTEGELIDLSGGILAVGHETTANHI 244 Query 243 TTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRK 301 + L +L+ P L P L+P+ VEELLR + L + G +A+ D+++G L+RK Sbjct 245 SNLLYTLLTNPDQLARLRADPGLMPSAVEELLRFVPLGASAGFAHIASEDVEIGGQLIRK 304 Query 302 GELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEA 361 GE V LEGAN D F P ++L R H+ FG G H C G+ + R Q+ + Sbjct 305 GEAVFADLEGANRDATVFECPEDLDLARTR-NHHVGFGHGPHHCLGAQMARLELQVALGT 363 Query 362 LLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 LL + P ++LA ++ W T ++R PERL + W Sbjct 364 LLARFPDLELAA---EVPWLTARRQRGPERLELTW 395 >gi|112791729|gb|ABI22127.1| cytochrome P450 hydroxylase [Streptomyces lavendulae] Length=395 Score = 172 bits (436), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 136/405 (34%), Positives = 191/405 (48%), Gaps = 19/405 (4%) Query 1 MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 MT T PF A+ +A LR EPI +V G EAWLV+ A +VL D RF Sbjct 1 MTTTPAPSYPFPAKYLDEAAELARLRQEEPISRVTMPYGGEAWLVTRMADVKEVLADPRF 60 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNI---ADAGLRKAVMKAITPKAPGLEQF---LR 114 S + A PR P VV +G + LR+ V KA T + +++F ++ Sbjct 61 SRQLQTEADRPRF----FPEPVVEGIGIMDPPEQTRLRRLVAKAFTARR--VQEFGPRVQ 114 Query 115 DTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADP 174 + LLD + +GAPADL DF+ L C+ +G+P ED + F + +S+ Sbjct 115 TIVDELLDAVEAKGAPADLYADFSWQLPGISICEFMGVPYEDRDR-FVPFFDSVVSTTSK 173 Query 175 IPAAKINWDRDIE-YMAGILENPNITTG--LMGELSRLRKDPAYSHVSDELFATIGVTFF 231 P D+ Y ++E T G L L R R + +S++ + Sbjct 174 TPDEIRQAIGDLHAYFGELIERRRATPGDDLFTALIRARDED--DRLSEKELIEMSFGLL 231 Query 232 GAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATAD 291 AG+ +T S L L L + P LL KPEL+P VEELLR A P +A D Sbjct 232 VAGMETTASQLANFLYLLFRNPDQLELLRAKPELVPNAVEELLRFVPLLAVDQPSVARED 291 Query 292 IQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALG 351 + +G VL+R GE V+ + AN D + F NP I++ R N HLAF G H C G+ L Sbjct 292 VTLGGVLIRAGETVVPSMNSANRDADVFENPQRIDVTREN-NPHLAFSHGAHHCVGAQLA 350 Query 352 RRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 R + +LL + PG+ AVP ++L W+ R E LPV W Sbjct 351 RMEMVTALRSLLVRFPGLHQAVPDEELRWKAGVVLRGVEALPVAW 395 >gi|182440582|ref|YP_001828301.1| putative cytochrome P450 [Streptomyces griseus subsp. griseus NBRC 13350] gi|178469098|dbj|BAG23618.1| putative cytochrome P450 [Streptomyces griseus subsp. griseus NBRC 13350] Length=397 Score = 172 bits (435), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 125/381 (33%), Positives = 186/381 (49%), Gaps = 12/381 (3%) Query 21 AVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPP 80 A+ E+ P+ +VR G + WLV+ YA VL D RFS A PR A+ PP Sbjct 24 ALVEICGEHPVLRVRLPFGGDGWLVTRYADVRAVLSDPRFSRSAAAGDHVPRTVAVAPPP 83 Query 81 EVVNNMGNIADAGLRKAVMKAITPKA-PGLEQFLRDTANSLLDNLITEGAPADLRNDFAD 139 + M LR+ VM+A T ++ L + + N L+D + PADL Sbjct 84 TSIMGMDPPDHTRLRRRVMRAFTVRSIDALRPRIAEIVNDLVDTMTEGDGPADLAAVLTW 143 Query 140 PLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDI-EYMAGILENPNI 198 PL + C++LG+P+ D + F + DP +A R + +Y+A ++ Sbjct 144 PLPITVICEMLGVPRADQDR-FTEWVDGLLILDDPERSADAR--RQLGDYLAVLIAQRRA 200 Query 199 --TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLR 256 T L+GEL+ D +S+E +GV+ AG +T + + + +L+ RP L Sbjct 201 EPTDDLLGELA---ADSGKDPLSEEELVGLGVSLLSAGQEATANQIGNFVYTLLTRPALW 257 Query 257 NLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFD 315 L P ++P VEEL R I +S G R+AT D+++G L+R G+ V+ L AN D Sbjct 258 RELVADPSIVPRAVEELSRFIPISATAGFTRVATEDLELGGQLIRAGDAVVAELGMANRD 317 Query 316 PEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPI 375 F P I+ R H+ FG G H C G+ L R ++ +E L+ ++PG+ LAVP Sbjct 318 SAVFDRPEEIDFHREQ-IPHVTFGYGIHHCLGAQLARVELRVVLETLVTRLPGLRLAVPA 376 Query 376 DQLVWRTRFQRRIPERLPVLW 396 DQL WRT R LPV W Sbjct 377 DQLAWRTERLIRGVAALPVRW 397 >gi|326781255|ref|ZP_08240520.1| Linalool 8-monooxygenase [Streptomyces cf. griseus XylebKG-1] gi|326661588|gb|EGE46434.1| Linalool 8-monooxygenase [Streptomyces griseus XylebKG-1] Length=397 Score = 172 bits (435), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 125/381 (33%), Positives = 186/381 (49%), Gaps = 12/381 (3%) Query 21 AVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPP 80 A+ E+ P+ +VR G + WLV+ YA VL D RFS A PR A+ PP Sbjct 24 ALVEICGEHPVLRVRLPFGGDGWLVTRYADVRAVLSDPRFSRSAAAGDHVPRTVAVAPPP 83 Query 81 EVVNNMGNIADAGLRKAVMKAITPKA-PGLEQFLRDTANSLLDNLITEGAPADLRNDFAD 139 + M LR+ VM+A T ++ L + + N L+D + PADL Sbjct 84 TSIMGMDPPDHTRLRRRVMRAFTVRSIDALRPRIAEIVNDLVDTMTEGDGPADLAAVLTW 143 Query 140 PLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDI-EYMAGIL--ENP 196 PL + C++LG+P+ D + F + DP +A R + +Y+A ++ Sbjct 144 PLPITVICEMLGVPRADQDR-FTEWVDGLLILDDPERSADAR--RQLGDYLAVLIARRRA 200 Query 197 NITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLR 256 T L+GEL+ D +S+E +GV+ AG +T + + + +L+ RP L Sbjct 201 EPTDDLLGELA---ADSGKDPLSEEELVGLGVSLLSAGQEATANQIGNFVYTLLTRPALW 257 Query 257 NLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFD 315 L P ++P VEEL R I +S G R+AT D+++G L+R G+ V+ L AN D Sbjct 258 RELVADPSIVPRAVEELSRFIPISATAGFTRVATEDLELGGQLIRAGDAVVAELGMANRD 317 Query 316 PEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPI 375 F P I+ R H+ FG G H C G+ L R ++ +E L+ ++PG+ LAVP Sbjct 318 SAVFDRPEEIDFHREQ-IPHVTFGYGIHHCLGAQLARVELRVVLETLVTRLPGLRLAVPA 376 Query 376 DQLVWRTRFQRRIPERLPVLW 396 DQL WRT R LPV W Sbjct 377 DQLAWRTERLIRGVAALPVRW 397 >gi|45934782|gb|AAS79446.1| P450 [Streptomyces bikiniensis] Length=401 Score = 171 bits (434), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 129/401 (33%), Positives = 193/401 (49%), Gaps = 13/401 (3%) Query 2 TATVLLEVPFSA-RGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 T T + PF G + +A + R E + V G WLVS Y VL DRRF Sbjct 8 TKTAPVSYPFGRPEGLDLDEAYEQARKSEGLLWVHMPYGEPGWLVSRYDDARFVLGDRRF 67 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANS 119 S A APR+ L P ++ M LR V KA TP+ + +R S Sbjct 68 SHAAEAENDAPRMRELRTPNGIIG-MDAPDHTRLRGLVTKAFTPRRVEAMRPHVRRMTAS 126 Query 120 LLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAK 179 LL ++ G+P DL + +A PL A+ C +LG+P+ED LFR MS++ Sbjct 127 LLRDMTALGSPVDLVDHYAVPLPVAVICGLLGVPEED-RDLFRGWCEIAMSTSSLTAEDH 185 Query 180 INWDRDIE-YMAGILENPNIT--TGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVI 236 + ++ Y+A ++ L+ L R A +S E + V AG Sbjct 186 VRLAGELTGYLADLITARRAAPRDDLVSALVEARD--AQGRLSQEELVDLIVFLLFAGHE 243 Query 237 STGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVG 295 +T S ++ ++ L+++P LL ++P+L+ VEEL R + L G PR AT D++VG Sbjct 244 TTASQISNFVLVLLEQPDQLALLRDRPDLLDNAVEELTRFVPLGSQAGFPRYATEDVEVG 303 Query 296 DVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHA 355 LVR G+ VLV + AN D F +PG +++ R + HL +G G H C G++L R Sbjct 304 GTLVRAGDPVLVQMNAANRDALRFRSPGVLDITRDDAGRHLGYGHGPHHCLGASLARLEL 363 Query 356 QIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 Q + LL ++PG+ LA P++ W+T R P + V W Sbjct 364 QEALRTLLDELPGLHLAQPVE---WKTEMVVRGPRTMLVGW 401 >gi|271966572|ref|YP_003340768.1| cytochrome P450, nitric oxide reductase [Streptosporangium roseum DSM 43021] gi|270509747|gb|ACZ88025.1| CYP55B1; cytochrome P450, nitric oxide reductase [Streptosporangium roseum DSM 43021] Length=398 Score = 171 bits (434), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 131/383 (35%), Positives = 191/383 (50%), Gaps = 9/383 (2%) Query 19 PDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTV 78 P +A LR P+ +V TG AWLV+ Y QVL D RFS GAP++ A Sbjct 20 PPELARLREEAPVTRVTLPTGDRAWLVTRYEDVKQVLGDPRFSRAAAELPGAPQMGASNP 79 Query 79 PPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDF 137 P+V+ M A LR+ + T + L + R A L+D+LI+ G PAD+ + F Sbjct 80 GPDVLLGMDGPEHARLRRTATRHFTARRVEALRPWTRLLAERLMDDLISAGPPADMVSRF 139 Query 138 ADPLATALHCKVLGIPQEDGPKLFRSLSIAF-MSSADP--IPAAKINWDRDIEYMAGILE 194 A PL L +LG+P ED +L AF M+ P I A+ + + M GI Sbjct 140 ALPLPLRLVLALLGVPDEDSARLCALTDTAFSMTRHTPQEILDARGRLESYMAEMIGIRR 199 Query 195 NPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ 254 T L+G L R ++++ + AG +ST + + + ++L+ P Sbjct 200 R-RPTDDLLGALVAERDK--EDRLTEQQLISFAFLLVTAGYLSTSNAIASGFLTLLAHPD 256 Query 255 LRNLLHEKPELIPAGVEELLRINLSFADG-LPRLATADIQVGDVLVRKGELVLVLLEGAN 313 + L PELI + EELLR+N S G L R+A D+++G V +R GE VL + AN Sbjct 257 QLDRLRGDPELISSAAEELLRVNPSAITGALLRVALEDVELGGVGIRAGEGVLPAIGSAN 316 Query 314 FDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAV 373 D FP+P +++ R + SHLAFG G H C G+ + R Q+ + LL+++P LAV Sbjct 317 HDALLFPDPERLDIVRED-ASHLAFGYGVHRCLGAHMARMELQVALAVLLERLPAARLAV 375 Query 374 PIDQLVWRTRFQRRIPERLPVLW 396 P +LVW+ R LPV W Sbjct 376 PEQELVWKDHPVSRGLVALPVTW 398 >gi|297162535|gb|ADI12247.1| cytochrome P450-like enzyme [Streptomyces bingchenggensis BCW-1] Length=400 Score = 171 bits (433), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 143/402 (36%), Positives = 199/402 (50%), Gaps = 32/402 (7%) Query 10 PF-SARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFS-----MK 63 PF S+ G + A E R R + +VR G AWLV+ YA VL DRRFS + Sbjct 16 PFNSSEGLGLSQAYQEARNRPGLVRVRMAYGEPAWLVTRYAEARLVLGDRRFSRAAALHR 75 Query 64 ETAAAGAPRLNA--LTV-PPEVVNNMGNIADAGLRKAVMKAIT-PKAPGLEQFLRDTANS 119 + G R N+ LT+ PPE LR V KA T + L +R + Sbjct 76 DEPRQGEGRRNSGILTMDPPEHTR---------LRTLVAKAFTVHQVEKLRPSVRQLTHE 126 Query 120 LLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAK 179 LLD L G PADL + +A P+ + C++LG+P+ED PK FR+ S A +S++ + A + Sbjct 127 LLDGLEAAGPPADLVDRYALPIPVGVICRLLGVPEEDRPK-FRAWSDAALSTSS-LSAEE 184 Query 180 INWDRD--IEYMAGILENPNIT--TGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGV 235 + +RD YMAG++E LM L R A +S+ + V AG Sbjct 185 FDRNRDELRAYMAGLIEIHRAAPQDDLMTSLIEARD--AGDRLSELELVDLCVGILVAGH 242 Query 236 ISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQV 294 +T + + +++L+ P L E+P L+ VEELLR + L PR AT DI+V Sbjct 243 ETTATQIPNFVLTLLDHPGELRRLREEPALLNGAVEELLRFVPLGKGASQPRYATEDIEV 302 Query 295 GDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRH 354 G LVR GE VLV + AN D F PG + + RP T HL FG G H C G+ L R Sbjct 303 GGQLVRAGEPVLVAVGSANRDALRFDEPGKLNVARP-ATQHLGFGHGVHHCLGAPLARLE 361 Query 355 AQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 Q + AL+ + PG+ L +VW+ + R P +PV W Sbjct 362 LQEALGALITRFPGLCLT---GDVVWKDQMLVRGPRVMPVGW 400 >gi|254385126|ref|ZP_05000459.1| cytochrome P-450 [Streptomyces sp. Mg1] gi|194344004|gb|EDX24970.1| cytochrome P-450 [Streptomyces sp. Mg1] Length=401 Score = 170 bits (431), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 127/401 (32%), Positives = 195/401 (49%), Gaps = 13/401 (3%) Query 2 TATVLLEVPFS-ARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 T + + PFS + G + +A + + E + V G +WLV Y VL DRRF Sbjct 8 TKSAPVSYPFSRSTGLDLDEAYEQAQKSEGLLWVHMPYGEPSWLVCRYDDARFVLGDRRF 67 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANS 119 S A APR+ L P ++ M LR V +A TP+ + +R S Sbjct 68 SHAAEAENDAPRMRELRTPNGILG-MDAPDHTRLRGLVTRAFTPRRVEAMRPHVRKMTES 126 Query 120 LLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAK 179 LL ++ GAPADL +A P+ A+ C +LG+P+ED LFR MS++ Sbjct 127 LLQDMTALGAPADLVEHYAVPIPVAVICGLLGVPEED-RALFRGWCDIAMSTSSLTAEDH 185 Query 180 INWDRDIE-YMAGILENPNIT--TGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVI 236 + ++ Y+A ++ + L+ L R A +S E + V AG Sbjct 186 VRLAGELTGYLADLIADRRAAPQDDLVSALVEARD--AEGRLSQEELVNLIVFLLFAGHE 243 Query 237 STGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVG 295 +T S ++ ++ L+++P LL ++P+L+ VEEL R + L G PR AT D++VG Sbjct 244 TTASQISNFVLLLLEQPDQLALLRDRPDLLDNAVEELTRFVPLGSQAGFPRYATEDVEVG 303 Query 296 DVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHA 355 LVR GE VLV + AN D F +PG +++ R + HL +G G H C G++L R Sbjct 304 GTLVRAGEPVLVQMNAANRDALRFRSPGVLDITRDDARQHLGYGHGPHHCLGASLARLEL 363 Query 356 QIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 Q + LL +PG+ LA ++ W+T+ R P + V W Sbjct 364 QEALRTLLDGLPGLHLAQAVE---WKTQMVVRGPRTMLVAW 401 >gi|300787492|ref|YP_003767783.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|299797006|gb|ADJ47381.1| cytochrome P450 [Amycolatopsis mediterranei U32] gi|340529020|gb|AEK44225.1| cytochrome P450 [Amycolatopsis mediterranei S699] Length=395 Score = 170 bits (430), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 125/400 (32%), Positives = 190/400 (48%), Gaps = 14/400 (3%) Query 5 VLLEVPFSAR-GDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMK 63 V ++ PF R G + L + P+ + R G + WL Y + QVL D F + Sbjct 2 VSVDYPFDTRAGADVDLEGLRLLEKAPLARARLDGGQDVWLALGYQVVRQVLSDPGFGRE 61 Query 64 ETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQF---LRDTANSL 120 G P N PE++ +M +R V KA +P+ +E+ + + + L Sbjct 62 AATRPGGPVTNPAGANPELLVSMDPPRHTRVRALVAKAFSPRT--VERLGPRVGEMVDGL 119 Query 121 LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSA---DPIPA 177 LD L + PADL A+PL + C++LG+P D ++ + +A + I A Sbjct 120 LDELAVQPRPADLVRLLAEPLPILVICELLGVPDADRARIREWAGVLIAETAHTGEEIAA 179 Query 178 AKINWDRDI-EYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVI 236 A D + E +A ENP+ L+ L + + + S EL + + + AG Sbjct 180 AIGQVDGYLGELIAQRRENPD--AALISALIAVNDEAGHLSPS-ELVSNVQLLLI-AGHE 235 Query 237 STGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGD 296 +T S + +L++L P LL E+PEL+P VEELLR + LPR+A D+ VGD Sbjct 236 TTVSQIGNSLVTLFGHPDQLKLLRERPELLPGAVEELLRHSKLTTSTLPRVAVRDVMVGD 295 Query 297 VLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQ 356 LVR GE V+ ++ AN DP FP P ++ R P H+ G G H+C G+ L + Sbjct 296 TLVRAGEAVIPVIAVANRDPAAFPEPHRFDISRTGPAPHVGLGHGPHYCLGAQLAKLELH 355 Query 357 IGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + I LL + P V AV +D+L W+ R LPV W Sbjct 356 VAIGGLLSRFPAVWPAVDLDELDWKPGLSTRSVRALPVTW 395 >gi|324997918|ref|ZP_08119030.1| cytochrome P450 hydroxylase [Pseudonocardia sp. P1] Length=419 Score = 169 bits (428), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 131/383 (35%), Positives = 193/383 (51%), Gaps = 15/383 (3%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPR-LNALTVPPE 81 AELR EP+ ++R G E L + Y V+ D RFS A PR L PE Sbjct 43 AELRREEPLARIRMPYGEEGRLATRYDDVRTVMSDPRFSRAAVVGADVPRALPERPGQPE 102 Query 82 VVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDFADP 140 + N+ LR+ V A T + + + A+ L+D L+ G+PADL + + P Sbjct 103 SIINIDPPEHGRLRRLVAAAFTARRVERMRPHVAGIADDLVDGLVAGGSPADLVSAVSMP 162 Query 141 LATALHCKVLGIPQEDGPKLFRSLSIAFMS-SADPIPAAKINWDRDIEYMAGIL-ENPNI 198 + C++LG+P DG FR+ + A +S SA P+ + Y+A ++ E + Sbjct 163 FPVIVICELLGVPL-DGRDTFRAAADAALSTSAVPVEERRQAMTDLHTYIASLVAERRDR 221 Query 199 TTG----LMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ 254 G ++G L R D +S+ ++G AG +T + + +L+ Sbjct 222 PDGPGDDVLGGLVSARDDDG-DRLSEGEMVSLGSAILLAGHETTMNMTGNMVRTLLHERS 280 Query 255 LRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGAN 313 + L +P+ IPA VEE+LR I L GLPR+ATAD+++ VR GE VLV AN Sbjct 281 RWDALVAEPDGIPAAVEEMLRFIPLGRQAGLPRIATADVELTGGTVRAGEAVLVSTNAAN 340 Query 314 FDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAV 373 DPE F +P ++ LDR +P +H+AFG G H C G++L R Q + AL ++PG+DLA Sbjct 341 RDPEVFDDPDALHLDR-SPGAHVAFGYGPHHCLGASLARMELQTILRALTTRLPGLDLA- 398 Query 374 PIDQLVWRTRFQRRIPERLPVLW 396 D + WR R P RLPV W Sbjct 399 --DDVEWRATSAVRGPARLPVTW 419 >gi|302547788|ref|ZP_07300130.1| cytochrome P450 107B1 (P450CVIIB1) [Streptomyces hygroscopicus ATCC 53653] gi|302465406|gb|EFL28499.1| cytochrome P450 107B1 (P450CVIIB1) [Streptomyces himastatinicus ATCC 53653] Length=396 Score = 169 bits (427), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 135/388 (35%), Positives = 192/388 (50%), Gaps = 27/388 (6%) Query 21 AVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPP 80 A E R R + +VR G AWL + YA VL DRRFS E PR + Sbjct 24 AYEEARHRPGLVRVRLRYGEPAWLATRYADARLVLGDRRFSRAEALNRDTPRQGEGQMDG 83 Query 81 EVVNNMGNIADAGLRKAVMKAIT-PKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFAD 139 +++ M LR V KA T + L ++R+ +SLLD L G PADL + +A Sbjct 84 GILS-MDPPDHTRLRTLVAKAFTVHQVEKLRPYVRELTHSLLDELEAAGPPADLVDRYAL 142 Query 140 PLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIE----YMAGILEN 195 P+ A+ C++LG+P+ED PK FR S A +S++ A W+R+ E YMA +++ Sbjct 143 PIPVAVICRLLGVPEEDRPK-FRVWSDAALSTSSLTAA---EWERNREELRAYMARLVQE 198 Query 196 ------PNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISL 249 +I T L+ +R + D +S+ + V AG +T + + ++ L Sbjct 199 HREAPRDDIMTSLIE--ARDQGD----RLSELELVDLCVGILVAGHETTATQIPNFVMVL 252 Query 250 IQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVL 308 + P L E+PELI VEEL+R + L R AT DI+VG LVR GE VLV Sbjct 253 LDHPDELRRLREEPELIKGSVEELMRFVPLGVGASQARYATEDIEVGGTLVRAGEPVLVA 312 Query 309 LEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPG 368 + AN D F PG + + RP T HL FG G H C G+ L R Q + AL+ + P Sbjct 313 VGSANRDALRFDEPGRLNVARPA-TQHLGFGHGVHHCLGAPLARLELQEALGALIGRFPN 371 Query 369 VDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + LA +VW+ + R P +PV W Sbjct 372 LHLA---GDVVWKDQMLVRGPRVMPVGW 396 >gi|29827712|ref|NP_822346.1| cytochrome P450 [Streptomyces avermitilis MA-4680] gi|29604812|dbj|BAC68881.1| putative cytochrome P450 [Streptomyces avermitilis MA-4680] Length=401 Score = 168 bits (426), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 121/395 (31%), Positives = 195/395 (50%), Gaps = 10/395 (2%) Query 9 VPFS-ARGDRIPDAVAELRTREPIRKVRTITG-AEAWLVSSYALCTQVLEDRRFSMKETA 66 PF ++G ++AEL R+ I ++R G A+AWLV+ + QV D+RFS Sbjct 10 CPFDFSKGLEFDPSLAELMARDSITRIRLPYGDADAWLVTGFDAVRQVTTDQRFSRAGIM 69 Query 67 AAGAPRLNAL-TVPPEVVNNMGNIADAGLRKAVMKAITP-KAPGLEQFLRDTANSLLDNL 124 + PRL V PE +N + + LR+ V +A T + + + A++LLD + Sbjct 70 GSDYPRLTPEPIVSPESINVVDPPHSSRLRRLVSQAFTKGHVERMRRRIVRLADTLLDEM 129 Query 125 ITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDR 184 +G PADL + ++ L C VLGI Q+D P++ + + + D +A Sbjct 130 AAQGPPADLAHHLSNRLPQHTICDVLGIEQDDWPRMEQYVHQLLSTGPDSRQSAATAKSE 189 Query 185 DIEYMAGILENPNITTG--LMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFL 242 EY G++E + G L+ L+ + + D+ A + +T +G + + Sbjct 190 LREYFGGLVEKRRSSPGNDLISALAAAKD--GEDVLDDQELAVMALTLMLSGHDTATCQI 247 Query 243 TTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRK 301 + L+ RP+L L +P+ + A + E+LR I G+PR+A D +V V +R Sbjct 248 SNICYLLLTRPELMKHLRSRPDTLTAVLNEMLRFIPFRKGVGIPRVAVEDAEVDGVKIRA 307 Query 302 GELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEA 361 G+ V V AN DPE +P+P +I+ DRP+ H+ FG G H C L ++ I Sbjct 308 GDFVHVSYLTANRDPERYPDPDAIDPDRPS-LPHMTFGWGGHRCIAVPLAMAELEVAIGR 366 Query 362 LLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 LL++ P + LAVP +++ W T RR P LPV W Sbjct 367 LLERFPELRLAVPPEEVRWDTETIRRFPIELPVAW 401 >gi|134098012|ref|YP_001103673.1| cytochrome P450-like enzyme [Saccharopolyspora erythraea NRRL 2338] gi|291007223|ref|ZP_06565196.1| cytochrome P450-like enzyme [Saccharopolyspora erythraea NRRL 2338] gi|133910635|emb|CAM00748.1| cytochrome P450-like enzyme [Saccharopolyspora erythraea NRRL 2338] Length=398 Score = 167 bits (424), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 125/380 (33%), Positives = 186/380 (49%), Gaps = 12/380 (3%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 A LR +EP+ +V+ G AWL + Y VL D RFS PR+ + Sbjct 22 ARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFSRAAVLEKDEPRMRPGITGGGI 81 Query 83 VNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDFADPL 141 ++ M LR+ V KA T + L ++ A+ L+D +I G+PADL +FA PL Sbjct 82 LS-MDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLVDRMIEHGSPADLVEEFALPL 140 Query 142 ATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINW-DRDIEYMAGILENPNI-- 198 + C++LG+P ED FR S AF+S+ P +++ DR YMAG++ + Sbjct 141 PITVICELLGVPYEDRDD-FREWSDAFLSTTKLTPEQVVDYMDRMFGYMAGLIAKRRVDP 199 Query 199 TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRP-QLRN 257 LM L R + + ++++ + AG +T + + + L+ P QL Sbjct 200 QDDLMSALIEARDE--HDKLTEQEMVQLAAGILVAGHETTATQIPNFVYVLLTHPDQLEG 257 Query 258 LLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDP 316 LL + L P VEEL R + L A R A D+++G V VR GE VLV AN D Sbjct 258 LLADLDGL-PRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVRAGEPVLVSASSANRDE 316 Query 317 EHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPID 376 F +P ++L R N +H+ FG G H C G+ L R Q+G+ LL ++PG+ A D Sbjct 317 AVFDDPDRLDLTREN-NAHIGFGHGPHHCLGAQLARLELQVGLRTLLTRLPGLRFAGGED 375 Query 377 QLVWRTRFQRRIPERLPVLW 396 +VW+ R P +L V W Sbjct 376 DVVWKEGMLVRGPSKLEVAW 395 >gi|256376814|ref|YP_003100474.1| cytochrome P450 [Actinosynnema mirum DSM 43827] gi|255921117|gb|ACU36628.1| cytochrome P450 [Actinosynnema mirum DSM 43827] Length=395 Score = 167 bits (424), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 131/396 (34%), Positives = 193/396 (49%), Gaps = 20/396 (5%) Query 10 PFSAR-GDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PFS G + AELR+ EP+ +V+ G +WL Y VL D RFS Sbjct 11 PFSEELGIHVDPIYAELRSAEPVNRVQMPYGEVSWLTLGYEDTKTVLTDPRFSRAAAQGQ 70 Query 69 GAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITE 127 PRL + E + + LRK KA+T + + A D++I Sbjct 71 DQPRLRE-EMAYEGIVGLDPPDHTRLRKLAGKALTARRVNAMRPHAVRIAEKCADDMIAH 129 Query 128 GAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIE 187 G+P DL FA P A+ C ++G+P ED K FR + ++A P+ + + Sbjct 130 GSPVDLVEHFALPFPIAVICDLIGVPFEDRGK-FRVWTDGLTNTAKPVMSQA---EELFA 185 Query 188 YMAGIL----ENPNITTGLMGELSRLRKDPAYSHVSDEL-FATIGVTFFGAGVISTGSFL 242 YMA ++ E P T L+ L R R D + L A++G+ G+ +ST + Sbjct 186 YMATLVAQRREEP--TDDLLTALVRARDDEDQLTEQELLSIASVGLLLTGSEAVST--HI 241 Query 243 TTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRK 301 L +L+ P+ L +PELIPA VEE+LR I L+ A PR AT D+++G ++VR+ Sbjct 242 PNFLYALLTSPEHYEQLKAEPELIPAAVEEMLRFIPLNPAALFPRYATEDVKLGTIVVRE 301 Query 302 GELVLVLLEGANFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALGRRHAQIGIE 360 GE +L + GAN DPE F P ++ R NP H+AFG G H C G+ L R Q+ +E Sbjct 302 GEPILASIPGANRDPEVFAEPEKMDFTRESNP--HVAFGHGPHHCLGAQLARMELQVMLE 359 Query 361 ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 + K P + LA + + W+ R P++L V W Sbjct 360 VITTKFPNLRLAEGDEGVEWKRGLLVRGPKKLRVAW 395 >gi|310817536|ref|YP_003949894.1| cytochrome p450, b class [Stigmatella aurantiaca DW4/3-1] gi|309390608|gb|ADO68067.1| Cytochrome P450, B class [Stigmatella aurantiaca DW4/3-1] Length=472 Score = 167 bits (423), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 125/385 (33%), Positives = 183/385 (48%), Gaps = 22/385 (5%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 AEL EP+ +VR G EAWL++ YA Q L D RFS + A R+ L + P Sbjct 99 AELCREEPVSRVRMPFGGEAWLLTGYAEIKQFLADPRFSSLKATAPDTARVTPLPLRPGN 158 Query 83 VNNMGNIADAGLRKAVMKAIT-PKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPL 141 + M +R+ V KA T + L +RD + LD L+ +G PADL A PL Sbjct 159 LLTMDPPDHTRIRRVVAKAFTMRRVEQLRDRIRDVVDKQLDLLVAQGPPADLVASLAVPL 218 Query 142 ATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDI--EYMAGILEN---- 195 + ++ GIP D + R + ++A A +I+ R +Y +LE Sbjct 219 PVVMISELFGIPYADREQFRRYADVFVATTA--YDAVEIDRSRTALEQYFQELLEQRRSC 276 Query 196 --PNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRP 253 ++ + L+ + R P + A G+ AG ++ S ++ + L+ Sbjct 277 PTDDLVSTLLEAMDTERLTPLET-------ARTGIGILMAGHETSLSMISNSCFLLLSHR 329 Query 254 QLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGA 312 L L +P L+P VEELLR I L PR AT D+++G VL+RKGE V+ A Sbjct 330 ALYAQLVAEPLLLPTAVEELLRYIPLRSTGSFPRRATEDVELGGVLIRKGETVIFQRASA 389 Query 313 NFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDL 371 + D F P I+L R PNP HL FG G H C G++L R + IE L+++ P + L Sbjct 390 DRDERVFTCPEKIDLTRRPNP--HLGFGHGAHHCLGASLARCELSLAIEGLIRRFPNLRL 447 Query 372 AVPIDQLVWRTRFQRRIPERLPVLW 396 AVP ++ W+ R P L V W Sbjct 448 AVPDGEVPWKPGLIARCPAHLEVTW 472 >gi|115379072|ref|ZP_01466198.1| cytochrome P450 107B1 [Stigmatella aurantiaca DW4/3-1] gi|115363932|gb|EAU63041.1| cytochrome P450 107B1 [Stigmatella aurantiaca DW4/3-1] Length=458 Score = 167 bits (423), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 125/385 (33%), Positives = 183/385 (48%), Gaps = 22/385 (5%) Query 23 AELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEV 82 AEL EP+ +VR G EAWL++ YA Q L D RFS + A R+ L + P Sbjct 85 AELCREEPVSRVRMPFGGEAWLLTGYAEIKQFLADPRFSSLKATAPDTARVTPLPLRPGN 144 Query 83 VNNMGNIADAGLRKAVMKAIT-PKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPL 141 + M +R+ V KA T + L +RD + LD L+ +G PADL A PL Sbjct 145 LLTMDPPDHTRIRRVVAKAFTMRRVEQLRDRIRDVVDKQLDLLVAQGPPADLVASLAVPL 204 Query 142 ATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDI--EYMAGILEN---- 195 + ++ GIP D + R + ++A A +I+ R +Y +LE Sbjct 205 PVVMISELFGIPYADREQFRRYADVFVATTA--YDAVEIDRSRTALEQYFQELLEQRRSC 262 Query 196 --PNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRP 253 ++ + L+ + R P + A G+ AG ++ S ++ + L+ Sbjct 263 PTDDLVSTLLEAMDTERLTPLET-------ARTGIGILMAGHETSLSMISNSCFLLLSHR 315 Query 254 QLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGA 312 L L +P L+P VEELLR I L PR AT D+++G VL+RKGE V+ A Sbjct 316 ALYAQLVAEPLLLPTAVEELLRYIPLRSTGSFPRRATEDVELGGVLIRKGETVIFQRASA 375 Query 313 NFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDL 371 + D F P I+L R PNP HL FG G H C G++L R + IE L+++ P + L Sbjct 376 DRDERVFTCPEKIDLTRRPNP--HLGFGHGAHHCLGASLARCELSLAIEGLIRRFPNLRL 433 Query 372 AVPIDQLVWRTRFQRRIPERLPVLW 396 AVP ++ W+ R P L V W Sbjct 434 AVPDGEVPWKPGLIARCPAHLEVTW 458 >gi|80279144|gb|ABB52529.1| cytochrome P-450 [Streptomyces sp. KCTC 0041BP] Length=401 Score = 167 bits (422), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 126/401 (32%), Positives = 194/401 (49%), Gaps = 13/401 (3%) Query 2 TATVLLEVPFS-ARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 T + + PFS + G + +A + + + V G +WLV Y VL DRRF Sbjct 8 TKSAPVSYPFSRSTGLDLDEAYEQAQKSAGLLWVHMPYGEPSWLVCRYDDARFVLGDRRF 67 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANS 119 S A APR+ L P ++ M LR V +A TP+ + +R S Sbjct 68 SHAAEAENDAPRMRELRTPNGILG-MDAPDHTRLRGLVTRAFTPRRVEAMRPRVRKMTES 126 Query 120 LLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAK 179 LL ++ GAPADL +A P+ A+ C +LG+P+ED LFR MS++ Sbjct 127 LLQDMTALGAPADLVEHYAVPIPVAVICGLLGVPEED-RALFRGWCDIAMSTSSLTAEDH 185 Query 180 INWDRDIE-YMAGILENPNIT--TGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVI 236 + ++ Y+A ++ + L+ L R A +S E + V AG Sbjct 186 VRLAGELTGYLADLIADRRAAPQDDLVSALVEARD--AEGRLSQEELVNLIVFLLFAGHE 243 Query 237 STGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVG 295 +T S ++ ++ L+++P LL ++P+L+ VEEL R + L G PR AT D++VG Sbjct 244 TTASQISNFVLLLLEQPDQLALLRDRPDLLDNAVEELTRFVPLGSQAGFPRYATEDVEVG 303 Query 296 DVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHA 355 LVR GE VLV + AN D F +PG +++ R + HL +G G H C G++L R Sbjct 304 GTLVRAGEPVLVQMNAANRDALRFRSPGVLDITRDDARQHLGYGHGPHHCLGASLARLEL 363 Query 356 QIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 Q + LL +PG+ LA ++ W+T+ R P + V W Sbjct 364 QEALRTLLDGLPGLHLAQAVE---WKTQMVVRGPRTMLVAW 401 >gi|224969342|gb|ACN71221.1| cytochrome P450 monooxygenase [Actinoplanes sp. ATCC 53771] Length=396 Score = 166 bits (421), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 139/403 (35%), Positives = 200/403 (50%), Gaps = 18/403 (4%) Query 2 TATVLLEVPFSAR-GDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF 60 T T + PF+ G + +A A R E + +VR G AWL + YA VL DRRF Sbjct 4 TDTEFVAYPFNEDAGLELNEAYAAARATEGMLRVRLPHGEPAWLATRYADARFVLGDRRF 63 Query 61 SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAIT-PKAPGLEQFLRDTANS 119 S PR+ P +++ M LR V KA T + L + + A+ Sbjct 64 SRAMAVERDEPRMAPGRRPGGILS-MDPPDHTRLRTLVAKAFTMRRVELLRPRVAELASG 122 Query 120 LLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAK 179 L+ ++ +G PADL D+A P+ A+ C++LG+P ED PK FR S A +S++ P+ + Sbjct 123 LIQDMKAKGQPADLVEDYALPIPVAVICELLGVPVEDRPK-FRVWSDAALSTS-PLTTEE 180 Query 180 I--NWDRDIEYMAGILENPNI--TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGV 235 + N D YM ++E LM L R +S+ + + AG Sbjct 181 MMANQDELRAYMHVLVEQHRAEPQDDLMTALIEARD--VRDRLSELELVDMCIGILIAGH 238 Query 236 ISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQV 294 +T S + + +L+++P L +LIPA VEELLR I L G R AT DIQV Sbjct 239 ETTASQIPNFVYALLEQPDQLARLRADLDLIPAAVEELLRFIPLGAGAGFARYATEDIQV 298 Query 295 GDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALGRR 353 GDVLV++GE V+V + AN D F + ++E R NP HL FG G H C G+ L R Sbjct 299 GDVLVKEGEPVMVAIGAANRDALQFTSADTLEFGRESNP--HLGFGHGVHHCLGAPLARL 356 Query 354 HAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 Q + ALL+ +PG+ L I VW+T+ R P +P+ W Sbjct 357 ELQEALRALLRDLPGLHLDGDI---VWKTQMLVRGPRSMPIGW 396 >gi|325929638|gb|ADZ45320.1| cytochrome P450 [Streptomyces sp. NRRL 30471] Length=404 Score = 166 bits (420), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 129/399 (33%), Positives = 190/399 (48%), Gaps = 22/399 (5%) Query 10 PF-SARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PF ARG I A LR P+ V G +AWLV+ Y VL DRRFS T Sbjct 16 PFRQARGLGIDPEFARLRHDAPLACVAMPYGGQAWLVTRYEDVRTVLGDRRFSRAATLGR 75 Query 69 GAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKA-----PGLEQFLRDTANSLLDN 123 PRL L + + R+ V +A TP+ P +EQF+ + L+D Sbjct 76 DIPRLTPLVQQVPSILTLDPPDHTRHRRLVSRAFTPRRMEELRPKVEQFV----DELIDE 131 Query 124 LITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSS-ADPIP----AA 178 L+ G P D+ PL + C++LG+P + LF + S A S+ AD + A Sbjct 132 LLRHGPPVDMVAHVTRPLPVMVICEMLGVPFGER-HLFYTWSEAMRSTGADAVAKMKQAG 190 Query 179 KINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVIST 238 ++ WD + ++ ENP + L+G L R + +S++ + VT AG +T Sbjct 191 QLPWDYLADRISVERENP--SDNLLGTLVRACDEE--ERLSEQELVSFAVTLLLAGHETT 246 Query 239 GSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLR-INLSFADGLPRLATADIQVGDV 297 L L +L+ P R L +P ++ +EELLR + + G R+AT D+ + Sbjct 247 TDELGNFLYTLLVNPAHREQLRARPHMLGTAIEELLRFVPIGTLSGFTRIATEDVHLSGG 306 Query 298 LVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQI 357 LVR G+ V+V + AN D F +P ++ R P HLAFG G H C G+ L R + Sbjct 307 LVRAGDAVVVQADSANRDESVFADPDELDFQR-EPNRHLAFGYGPHHCLGAQLARIELRA 365 Query 358 GIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 I ALL ++P + LAVP ++ W+ P+ LPV W Sbjct 366 AIGALLTRLPALALAVPEHEVPWKLGRSALGPQALPVTW 404 >gi|254393795|ref|ZP_05008910.1| NocL [Streptomyces clavuligerus ATCC 27064] gi|294811320|ref|ZP_06769963.1| cytochrome P450-like enzyme [Streptomyces clavuligerus ATCC 27064] gi|326439946|ref|ZP_08214680.1| P450-like monoxygenase [Streptomyces clavuligerus ATCC 27064] gi|197707397|gb|EDY53209.1| NocL [Streptomyces clavuligerus ATCC 27064] gi|294323919|gb|EFG05562.1| cytochrome P450-like enzyme [Streptomyces clavuligerus ATCC 27064] Length=411 Score = 166 bits (419), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 125/386 (33%), Positives = 187/386 (49%), Gaps = 9/386 (2%) Query 17 RIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLNAL 76 ++P LR P+ KVR +G + ++VS Y VL D RFS A GAPRL A Sbjct 29 QVPPVYDRLRGECPVAKVRLPSGDDGYVVSRYDDVRTVLADPRFSRAAMLAEGAPRLTAA 88 Query 77 TVPPEVVNNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRN 135 + M LR+ V + T + L +++ + LLD + P DL Sbjct 89 PPMGGSLFTMDPPEHTRLRRLVSREFTARRVQNLRPRIQEMTDELLDGMEKLSPPVDLNP 148 Query 136 DFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDRD-IEYMAGILE 194 FA PL + C++LG+P ED + FR S AF+S P + ++Y+ +++ Sbjct 149 AFAFPLPVMVICELLGVPFEDRDR-FRGWSDAFVSLTSHTPEEVMEQRMSMVQYLGELVQ 207 Query 195 NPNI--TTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQR 252 T LMG L ++ D +S+ T+G+T AG +T S + T ++L++ Sbjct 208 RKRAEPTDDLMGALVQV-HDEDGGRLSEIELITMGITLLVAGHETTVSMIGTCALTLLRH 266 Query 253 PQLRNLLHEKPELIPAGVEELLRINLSFADGLP-RLATADIQVGDVLVRKGELVLVLLEG 311 P+ L P I VEELLRIN DG P R+ D++V D ++ +G V+ + Sbjct 267 PEHLAALKADPGSIDKVVEELLRIN-PIGDGGPFRVTLEDVEVADSVIPQGSGVIAAVCS 325 Query 312 ANFDPEHF-PNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVD 370 AN D F +PG + RP ++HLAFG G HFC G+AL R QI + +L ++ PG+ Sbjct 326 ANQDSARFGADPGVFDPSRPTASAHLAFGHGPHFCLGAALARAELQIALSSLFRRFPGLA 385 Query 371 LAVPIDQLVWRTRFQRRIPERLPVLW 396 LA + L + RLPV W Sbjct 386 LADEVRNLRMTSGMMVHALSRLPVTW 411 >gi|256375333|ref|YP_003098993.1| cytochrome P450 [Actinosynnema mirum DSM 43827] gi|255919636|gb|ACU35147.1| cytochrome P450 [Actinosynnema mirum DSM 43827] Length=394 Score = 165 bits (417), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 134/402 (34%), Positives = 192/402 (48%), Gaps = 29/402 (7%) Query 10 PFSARGDRIPDAVA-ELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAA 68 PF+ + PD A EL+ REP+ +VR G +AWLV+ +A VL D RFS T Sbjct 7 PFNEAVELRPDPTALELQEREPVSQVRLPYGGDAWLVTRHADVKTVLGDPRFSRAATLEL 66 Query 69 GA--PRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSLLDNLI- 125 GA PR L + M LRK V K T + + LR A ++D+L+ Sbjct 67 GADLPRAFPLHRTESNILTMDPPDHTRLRKLVAKGFTARR---TELLRARAQEIVDDLLD 123 Query 126 ---TEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINW 182 +G PAD+ A PL + C++LG+P D + FR+ S A MS P + Sbjct 124 AMEEQGPPADVVEALALPLPITIICEMLGVPVADRDR-FRAWSDAAMSITAFTPEEVLAA 182 Query 183 DRDI-EYMAGILENPNITTGLMGELSRLRKDPAYSH-----VSDELFATIGVTFFGAGVI 236 R + EY+AG++E+ G + D +H ++ T GVT AG Sbjct 183 ARSLREYIAGLVEDKRANPG-----DDVLTDLVTAHDGGGPLTATEVVTFGVTLLAAGHE 237 Query 237 STGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRIN-LSFADGLPRLATADIQVG 295 +T + + +L+ P L P L+P VEELLR L + G PR+AT D+++ Sbjct 238 TTANQIANFTHTLLANPDRMAELRADPALVPRAVEELLRFTPLGGSAGFPRIATEDVELS 297 Query 296 DVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR-PNPTSHLAFGRGQHFCPGSALGRRH 354 V V +G V V + N DPE F P I+ R NP H+AFG G H C G+ L R Sbjct 298 GVTVPRGAAVFVDIPSGNRDPEVFERPHEIDFHRAANP--HVAFGHGVHHCVGAQLARVE 355 Query 355 AQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW 396 Q+ + LL + PG++ P + V++ R P+ LPV W Sbjct 356 LQVAVGTLLARFPGLE---PAGEAVFKRGRLVRGPQSLPVRW 394 Lambda K H 0.321 0.138 0.407 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 776545622928 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40