BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2380c Length=1682 Score E Sequences producing significant alignments: (Bits) Value gi|31793557|ref|NP_856050.1| peptide synthetase MBTE (peptide sy... 3383 0.0 gi|289575073|ref|ZP_06455300.1| peptide synthetase mbtE [Mycobac... 3380 0.0 gi|289448022|ref|ZP_06437766.1| peptide synthetase mbtE [Mycobac... 3380 0.0 gi|340627391|ref|YP_004745843.1| peptide synthetase [Mycobacteri... 3372 0.0 gi|148823582|ref|YP_001288336.1| peptide synthetase mbtE [Mycoba... 3333 0.0 gi|15841892|ref|NP_336929.1| peptide synthetase [Mycobacterium t... 3330 0.0 gi|289750980|ref|ZP_06510358.1| LOW QUALITY PROTEIN: peptide syn... 3301 0.0 gi|126436055|ref|YP_001071746.1| amino acid adenylation domain-c... 2296 0.0 gi|108800432|ref|YP_640629.1| amino acid adenylation [Mycobacter... 2295 0.0 gi|120404803|ref|YP_954632.1| amino acid adenylation domain-cont... 2195 0.0 gi|289762546|ref|ZP_06521924.1| peptide synthetase mbtE [Mycobac... 2120 0.0 gi|118470602|ref|YP_888783.1| linear gramicidin synthetase subun... 2080 0.0 gi|315443743|ref|YP_004076622.1| amino acid adenylation enzyme/t... 2023 0.0 gi|145223283|ref|YP_001133961.1| amino acid adenylation domain-c... 2023 0.0 gi|289758503|ref|ZP_06517881.1| peptide synthetase mbtE [Mycobac... 2020 0.0 gi|240169032|ref|ZP_04747691.1| linear gramicidin synthetase sub... 1982 0.0 gi|296170584|ref|ZP_06852167.1| linear gramicidin synthetase sub... 1942 0.0 gi|118462221|ref|YP_881232.1| linear gramicidin synthetase subun... 1931 0.0 gi|41408271|ref|NP_961107.1| MbtE [Mycobacterium avium subsp. pa... 1919 0.0 gi|342857509|ref|ZP_08714165.1| linear gramicidin synthetase sub... 1909 0.0 gi|254819401|ref|ZP_05224402.1| linear gramicidin synthetase sub... 1895 0.0 gi|254774738|ref|ZP_05216254.1| linear gramicidin synthetase sub... 1880 0.0 gi|289570524|ref|ZP_06450751.1| predicted protein [Mycobacterium... 1797 0.0 gi|333990182|ref|YP_004522796.1| non-ribosomal peptide synthetas... 1733 0.0 gi|289443902|ref|ZP_06433646.1| LOW QUALITY PROTEIN: peptide syn... 1702 0.0 gi|336458167|gb|EGO37150.1| amino acid adenylation enzyme/thioes... 1595 0.0 gi|289443901|ref|ZP_06433645.1| predicted protein [Mycobacterium... 1388 0.0 gi|226361741|ref|YP_002779519.1| non-ribosomal peptide synthetas... 1328 0.0 gi|54022733|ref|YP_116975.1| putative non-ribosomal peptide synt... 1264 0.0 gi|289758502|ref|ZP_06517880.1| peptide synthetase mbtE [Mycobac... 1219 0.0 gi|169629208|ref|YP_001702857.1| putative peptide synthetase Mbt... 1190 0.0 gi|317506256|ref|ZP_07964075.1| amino acid adenylation domain-co... 1151 0.0 gi|240169923|ref|ZP_04748582.1| non-ribosomal peptide synthetase... 1138 0.0 gi|262200637|ref|YP_003271845.1| amino acid adenylation domain-c... 1129 0.0 gi|169629334|ref|YP_001702983.1| peptide synthetase MbtE [Mycoba... 1127 0.0 gi|118618906|ref|YP_907238.1| non-ribosomal peptide synthetase M... 1109 0.0 gi|183983671|ref|YP_001851962.1| non-ribosomal peptide synthetas... 1106 0.0 gi|302526154|ref|ZP_07278496.1| hypothetical protein SSMG_02536 ... 920 0.0 gi|291443461|ref|ZP_06582851.1| nonribosomal peptide synthetase ... 887 0.0 gi|111017166|ref|YP_700138.1| non-ribosomal peptide synthetase [... 873 0.0 gi|291436402|ref|ZP_06575792.1| pstC [Streptomyces ghanaensis AT... 872 0.0 gi|186682529|ref|YP_001865725.1| amino acid adenylation domain-c... 867 0.0 gi|226359675|ref|YP_002777453.1| non-ribosomal peptide synthetas... 858 0.0 gi|325675434|ref|ZP_08155118.1| hypothetical protein HMPREF0724_... 856 0.0 gi|312140928|ref|YP_004008264.1| non-ribosomal peptide synthetas... 855 0.0 gi|325675435|ref|ZP_08155119.1| exopolyphosphatase [Rhodococcus ... 854 0.0 gi|344943005|ref|ZP_08782292.1| amino acid adenylation domain pr... 853 0.0 gi|226305326|ref|YP_002765284.1| non-ribosomal peptide synthetas... 851 0.0 gi|327179725|gb|AEA30273.1| peptide synthetase [Streptomyces sp.... 850 0.0 gi|54027007|ref|YP_121249.1| putative non-ribosomal peptide synt... 848 0.0 >gi|31793557|ref|NP_856050.1| peptide synthetase MBTE (peptide synthase) [Mycobacterium bovis AF2122/97] gi|121638259|ref|YP_978483.1| peptide synthetase mbtE [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|148662212|ref|YP_001283735.1| peptide synthetase [Mycobacterium tuberculosis H37Ra] 26 more sequence titles Length=1682 Score = 3383 bits (8772), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1682/1682 (100%), Positives = 1682/1682 (100%), Gaps = 0/1682 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA Sbjct 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD Sbjct 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ Sbjct 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 Query 1681 WP 1682 WP Sbjct 1681 WP 1682 >gi|289575073|ref|ZP_06455300.1| peptide synthetase mbtE [Mycobacterium tuberculosis K85] gi|289539504|gb|EFD44082.1| peptide synthetase mbtE [Mycobacterium tuberculosis K85] Length=1682 Score = 3380 bits (8765), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1681/1682 (99%), Positives = 1681/1682 (99%), Gaps = 0/1682 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA Sbjct 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD Sbjct 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDEL ALTASWDQ Sbjct 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELLALTASWDQ 1680 Query 1681 WP 1682 WP Sbjct 1681 WP 1682 >gi|289448022|ref|ZP_06437766.1| peptide synthetase mbtE [Mycobacterium tuberculosis CPHL_A] gi|289420980|gb|EFD18181.1| peptide synthetase mbtE [Mycobacterium tuberculosis CPHL_A] Length=1682 Score = 3380 bits (8764), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1681/1682 (99%), Positives = 1681/1682 (99%), Gaps = 0/1682 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWI QLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA Sbjct 1201 LLDDGAGIVGPQRDYWILQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD Sbjct 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ Sbjct 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 Query 1681 WP 1682 WP Sbjct 1681 WP 1682 >gi|340627391|ref|YP_004745843.1| peptide synthetase [Mycobacterium canettii CIPT 140010059] gi|340005581|emb|CCC44743.1| peptide synthetase MBTE (peptide synthase) [Mycobacterium canettii CIPT 140010059] Length=1682 Score = 3372 bits (8742), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1678/1682 (99%), Positives = 1679/1682 (99%), Gaps = 0/1682 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDID ARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 1 MWFVQMADPSGALLNICVSYRITGDIDPARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRL HW Sbjct 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLAHW 480 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGD+VEFRLGAAIRDKLAA Sbjct 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDSVEFRLGAAIRDKLAA 1260 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEV EVGRYDDFFNLGGDSILATQVAARARD Sbjct 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVREVGRYDDFFNLGGDSILATQVAARARD 1620 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ Sbjct 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 Query 1681 WP 1682 WP Sbjct 1681 WP 1682 >gi|148823582|ref|YP_001288336.1| peptide synthetase mbtE [Mycobacterium tuberculosis F11] gi|253798543|ref|YP_003031544.1| peptide synthetase mbtE [Mycobacterium tuberculosis KZN 1435] gi|254232518|ref|ZP_04925845.1| peptide synthetase mbtE [Mycobacterium tuberculosis C] 28 more sequence titles Length=1731 Score = 3333 bits (8642), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1682/1682 (100%), Positives = 1682/1682 (100%), Gaps = 0/1682 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 50 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 109 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 110 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 169 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 170 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 229 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 230 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 289 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 290 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 349 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 350 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 409 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 410 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 469 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 470 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 529 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 530 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 589 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 590 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 649 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 650 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 709 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 710 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 769 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 770 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 829 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 830 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 889 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 890 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 949 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 950 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 1009 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 1010 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1069 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1070 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1129 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1130 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1189 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1190 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1249 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA Sbjct 1250 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1309 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1310 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1369 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1370 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1429 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1430 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1489 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1490 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1549 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1550 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1609 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD Sbjct 1610 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1669 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ Sbjct 1670 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1729 Query 1681 WP 1682 WP Sbjct 1730 WP 1731 Score = 114 bits (284), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 106/350 (31%), Positives = 151/350 (44%), Gaps = 41/350 (11%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 RLS Q R WF D A+ NI + + G D A+ V RH ILRT Y + Sbjct 42 RLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PV 100 Query 1089 GGVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAA 1138 G + QP +R A LR E+ +R + F+L D P+R Sbjct 101 GD--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRIT 158 Query 1139 LLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQ 1190 ++ T ++ VL LV HHIA D S V FTDL AY G RPS A P Sbjct 159 VVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT 218 Query 1191 YADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRL 1250 AD + W++ + D + + G T R RL Sbjct 219 EADLNYWRAIMADPPEPLE-------LPGPAGTCVPTSWR------------AARATLRL 259 Query 1251 GAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGF 1310 A ++A ++++ G T +M+L AA ++H+ D + APV R A + IG+ Sbjct 260 PADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGY 318 Query 1311 FINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 F N V +R + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 319 FGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 368 >gi|15841892|ref|NP_336929.1| peptide synthetase [Mycobacterium tuberculosis CDC1551] gi|308370993|ref|ZP_07667064.1| peptide synthetase mbtE [Mycobacterium tuberculosis SUMu003] gi|13882160|gb|AAK46743.1| peptide synthetase [Mycobacterium tuberculosis CDC1551] gi|308330151|gb|EFP19002.1| peptide synthetase mbtE [Mycobacterium tuberculosis SUMu003] Length=1787 Score = 3330 bits (8635), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1682/1682 (100%), Positives = 1682/1682 (100%), Gaps = 0/1682 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 106 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 165 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 166 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 225 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 226 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 285 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 286 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 345 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 346 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 405 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 406 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 465 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 466 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 525 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 526 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 585 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 586 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 645 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 646 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 705 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 706 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 765 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 766 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 825 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 826 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 885 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 886 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 945 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 946 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 1005 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 1006 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 1065 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 1066 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1125 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1126 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1185 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1186 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1245 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1246 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1305 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA Sbjct 1306 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1365 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1366 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1425 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1426 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1485 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1486 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1545 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1546 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1605 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1606 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1665 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD Sbjct 1666 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1725 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ Sbjct 1726 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1785 Query 1681 WP 1682 WP Sbjct 1786 WP 1787 Score = 114 bits (284), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 106/350 (31%), Positives = 151/350 (44%), Gaps = 41/350 (11%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 RLS Q R WF D A+ NI + + G D A+ V RH ILRT Y + Sbjct 98 RLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PV 156 Query 1089 GGVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAA 1138 G + QP +R A LR E+ +R + F+L D P+R Sbjct 157 GD--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRIT 214 Query 1139 LLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQ 1190 ++ T ++ VL LV HHIA D S V FTDL AY G RPS A P Sbjct 215 VVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT 274 Query 1191 YADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRL 1250 AD + W++ + D + + G T R RL Sbjct 275 EADLNYWRAIMADPPEPLE-------LPGPAGTCVPTSWR------------AARATLRL 315 Query 1251 GAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGF 1310 A ++A ++++ G T +M+L AA ++H+ D + APV R A + IG+ Sbjct 316 PADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGY 374 Query 1311 FINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 F N V +R + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 375 FGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 424 >gi|289750980|ref|ZP_06510358.1| LOW QUALITY PROTEIN: peptide synthetase mbtE [Mycobacterium tuberculosis T92] gi|289691567|gb|EFD58996.1| LOW QUALITY PROTEIN: peptide synthetase mbtE [Mycobacterium tuberculosis T92] Length=1732 Score = 3301 bits (8558), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1668/1668 (100%), Positives = 1668/1668 (100%), Gaps = 0/1668 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 50 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 109 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 110 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 169 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 170 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 229 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 230 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 289 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 290 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 349 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 350 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 409 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 410 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 469 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 470 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 529 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 530 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 589 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 590 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 649 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 650 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 709 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 710 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 769 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 770 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 829 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 830 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 889 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 890 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 949 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 950 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 1009 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 1010 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1069 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI Sbjct 1070 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1129 Query 1081 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1140 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL Sbjct 1130 LRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL 1189 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA Sbjct 1190 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1249 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA Sbjct 1250 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1309 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND Sbjct 1310 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1369 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ Sbjct 1370 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1429 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD Sbjct 1430 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1489 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG Sbjct 1490 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1549 Query 1501 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER Sbjct 1550 DVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1609 Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD Sbjct 1610 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1669 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSP 1668 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSP Sbjct 1670 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSP 1717 Score = 114 bits (284), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 106/350 (31%), Positives = 151/350 (44%), Gaps = 41/350 (11%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 RLS Q R WF D A+ NI + + G D A+ V RH ILRT Y + Sbjct 42 RLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PV 100 Query 1089 GGVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAA 1138 G + QP +R A LR E+ +R + F+L D P+R Sbjct 101 GD--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRIT 158 Query 1139 LLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQ 1190 ++ T ++ VL LV HHIA D S V FTDL AY G RPS A P Sbjct 159 VVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT 218 Query 1191 YADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRL 1250 AD + W++ + D + + G T R RL Sbjct 219 EADLNYWRAIMADPPEPLE-------LPGPAGTCVPTSWR------------AARATLRL 259 Query 1251 GAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGF 1310 A ++A ++++ G T +M+L AA ++H+ D + APV R A + IG+ Sbjct 260 PADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGY 318 Query 1311 FINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 F N V +R + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 319 FGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 368 >gi|126436055|ref|YP_001071746.1| amino acid adenylation domain-containing protein [Mycobacterium sp. JLS] gi|126235855|gb|ABN99255.1| amino acid adenylation domain [Mycobacterium sp. JLS] Length=1745 Score = 2296 bits (5949), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1206/1700 (71%), Positives = 1362/1700 (81%), Gaps = 32/1700 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ ADPSGALLN+CVSYRI G +DLA LR A++AVARRH +LRTTY D G +PT Sbjct 50 MWFVQAADPSGALLNVCVSYRIRGAVDLAALRGALDAVARRHPVLRTTYAADDTGAPRPT 109 Query 61 VHADLRPGWTQYDLTDL---SQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADE 117 VHADLRP W ++DLT L S++AQRLRLEVLAQREF APF+LS DAPLRIT+V T +DE Sbjct 110 VHADLRPAWAEHDLTGLANQSEQAQRLRLEVLAQREFAAPFDLSTDAPLRITMVHTGSDE 169 Query 118 HVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWR 177 +V+LLVAHHIAWDDGSW VFF DLT+AY+ DLG +L P H P+ P DL YWR Sbjct 170 YVMLLVAHHIAWDDGSWEVFFGDLTRAYAGEDLGEELEP-HVPAV---PRDAADDLAYWR 225 Query 178 AIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAF 237 +MADPPEPLELPGP G+ VPT WR+AR + L ADTA RV +A+ TGCTPY VLLA F Sbjct 226 RVMADPPEPLELPGPTGSAVPTGWRSARTGVALDADTARRVVDLARETGCTPYAVLLAVF 285 Query 238 GALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIA 297 G L+HRYTH+DDFLVA PVLNRG GTED IGY+GNTVAMRLRP ++MSFR++L TRD A Sbjct 286 GTLIHRYTHADDFLVATPVLNRGTGTEDRIGYYGNTVAMRLRPTTSMSFRDMLIQTRDTA 345 Query 298 SGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNI 357 GAFAHQ +N+D+VVRELNPDRRHG ERMTRVSFGFR PD GF P G+ CER DLRS++ Sbjct 346 LGAFAHQGVNVDQVVRELNPDRRHGTERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHL 405 Query 358 TQLPLGFMVEFDR----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSG 413 TQLPLG MVEFD G +VE EHLVEI+EPALA+Q+L HF VLL +AL PD TL+ Sbjct 406 TQLPLGVMVEFDAEPSGGGAVVEVEHLVEIIEPALAQQLLDHFVVLLGSALDRPDTTLAR 465 Query 414 LALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEA 473 LALM DAA L +V+RG+ FDTP +TL DL+ Q TPD AV YEG+H+TY ++NE Sbjct 466 LALMSAADAAWLHDVARGDHFDTPPRTLPDLIAAQAATTPDEIAVAYEGRHYTYREINEQ 525 Query 474 SNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILA 533 +NR+ HWLI QGIG+EDRVAVLLDKSP+LIVTALGV K+GAVYVPVDP+YP+DRL FIL Sbjct 526 ANRVAHWLIGQGIGAEDRVAVLLDKSPELIVTALGVAKAGAVYVPVDPTYPEDRLAFILG 585 Query 534 DCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPV 593 DCDAKLVLR PV L G + DPTDADR+RPL PDNTAYLIYTSGTTGLPKGV V HRPV Sbjct 586 DCDAKLVLREPVSGLDGTPAHDPTDADRVRPLLPDNTAYLIYTSGTTGLPKGVPVSHRPV 645 Query 594 AEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA 653 AEYFVWFK +Y VD DRLLQVASPSFDVSIAEIFG LACGAR+VI RPGGL DIGYLT Sbjct 646 AEYFVWFKADYQVDAKDRLLQVASPSFDVSIAEIFGMLACGARIVIHRPGGLNDIGYLTE 705 Query 654 LLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHN 713 LLRDE ITAMHFVPSLLGLFLSLPGV+QWRTLQRVPIGGEPLPGEVADKFHATFDALLHN Sbjct 706 LLRDERITAMHFVPSLLGLFLSLPGVNQWRTLQRVPIGGEPLPGEVADKFHATFDALLHN 765 Query 714 FYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTH 773 FYGPTETVINASR+KV G QGTRIVPIGRPKINT MHLLDD+LQPVP GVIGEIYIGGTH Sbjct 766 FYGPTETVINASRYKVEGKQGTRIVPIGRPKINTQMHLLDDALQPVPVGVIGEIYIGGTH 825 Query 774 VAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIE 833 VA+GYHRR GLTAERFVADPF PG R+YRSGDLARRNADGDIEFVGRADEQVKIRGFRIE Sbjct 826 VAHGYHRRPGLTAERFVADPFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIE 885 Query 834 LGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAA 893 LGDVAAAI+VDP+VGQAVV+VS+LP LGKSLVGY+TP +G D + V +DRIRARVAA Sbjct 886 LGDVAAAISVDPSVGQAVVMVSELPNLGKSLVGYLTPVSGEDRDS---VAVDRIRARVAA 942 Query 894 ALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELL 953 ALPEYM+PAAYVVLDE+PIT HGKIDRAALP P++ S +FR P T TER +A+LFGELL Sbjct 943 ALPEYMVPAAYVVLDEVPITTHGKIDRAALPAPELTSTVDFREPGTDTEREMARLFGELL 1002 Query 954 GRD-RVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS 1012 GR +GADDSFFDLGGHSLLATKLVAAVR + GVD+GV+E+FE ATV LAGH+D L + Sbjct 1003 GRSANIGADDSFFDLGGHSLLATKLVAAVRTSCGVDIGVQEVFELATVAQLAGHVDALRA 1062 Query 1013 DS---ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAA 1069 ARPRL + DGP LSSSQ+RSWF YR DGP+ VNNIPFAA L GPCD +A Sbjct 1063 GGGGPARPRLMPLHLDGPAPLSSSQLRSWFAYRVDGPSVVNNIPFAARLRGPCDVDALVT 1122 Query 1070 AITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDL 1129 AI DVV RHEILRTVYREI GVPHQ++ PP V VR A G WLRAEL+ ER +VFDL Sbjct 1123 AIGDVVNRHEILRTVYREIDGVPHQVVLPPEPVTVRRAHGDGEEWLRAELDRERAHVFDL 1182 Query 1130 ETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 E D PIR A+L P+ VLS+V+HHIAGDHWSA VLF DLLTAYRAR+ G+ P+WAPLP+ Sbjct 1183 EQDRPIRPAVLRVPDGVVLSVVMHHIAGDHWSATVLFADLLTAYRARAAGEAPAWAPLPL 1242 Query 1190 QYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFR 1249 QYAD+ WQSALL D AGI GPQRDYW RQL GL ETGLRPDF RP + SG AVEF Sbjct 1243 QYADFGAWQSALLADDAGIAGPQRDYWTRQLAGLPEETGLRPDFARPPVPSGRAGAVEFH 1302 Query 1250 LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIG 1309 + A RDKL A+ R+LGVTEFMLLQAAVAVVLHKAGGG DVP+G PVAGRSE LDQL+G Sbjct 1303 IDGATRDKLTALCRELGVTEFMLLQAAVAVVLHKAGGGPDVPLGTPVAGRSEPELDQLVG 1362 Query 1310 FFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFD 1369 FFINI+VLRNDLRGNPTLREV +R R+MAL AYAHQDLPFDQVV+AV+P R+L+RNPLF Sbjct 1363 FFINILVLRNDLRGNPTLREVCRRAREMALEAYAHQDLPFDQVVDAVSPVRTLARNPLFS 1422 Query 1370 IVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC--------GDEYRG 1421 +VVHVREQ+P+D VI GPDGDTT+ VLEPTFDAA ADLS+NFFA YRG Sbjct 1423 VVVHVREQLPEDRVIAHGPDGDTTVTVLEPTFDAAHADLSLNFFASERGVDGGFSSGYRG 1482 Query 1422 HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGT 1481 HVIYR ELY R TAQRF WL RVV AFAD+PD LR++E+ + +RRIL++ G Sbjct 1483 HVIYRPELYSRETAQRFVGWLGRVVTAFADQPDLTLRDLEIGAPGEQRRILEQWGGGG-- 1540 Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 V++LD+ L+PVPVGVVGDVY GGP A + TATRFVA P+ A G RL+R G Sbjct 1541 --VFVLDETLRPVPVGVVGDVYTAGGPLAAAHWGEAALTATRFVAHPYGADAGGRLHRTG 1598 Query 1542 ERGVWKADGQLELLAE--IERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYD 1599 ++ W ADG LEL+ + P +AA AEP T+TERALA +LADVL+V R+D Sbjct 1599 DQARWSADGVLELVGAEGLAAEPAVRAAGHTAEPPATDTERALATLLADVLDVEVTRRHD 1658 Query 1600 DFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHA 1659 DFF+LGGDSILA Q+AARARD G+ LTARMVFE P L +LAAAVDA V D HA Sbjct 1659 DFFSLGGDSILAVQLAARARDAGLRLTARMVFEQPTLYDLAAAVDAAADVSGPAGDTAHA 1718 Query 1660 PMSTSGLSPDELSALTASWD 1679 PMS SGLS DEL+ALTASW+ Sbjct 1719 PMSASGLSADELAALTASWN 1738 Score = 111 bits (278), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 129/460 (29%), Positives = 191/460 (42%), Gaps = 55/460 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 LS Q R WF D A+ N+ + + G D A A+ V RH +LRT Y + Sbjct 43 LSEGQQRMWFVQAADPSGALLNVCVSYRIRGAVDLAALRGALDAVARRHPVLRTTYAADD 102 Query 1089 GGVP----HQIIQPP-AEVPVRCAAGSD--AAWLRAELNNERGYV--FDLETDWPIRAAL 1139 G P H ++P AE + A A LR E+ +R + FDL TD P+R + Sbjct 103 TGAPRPTVHADLRPAWAEHDLTGLANQSEQAQRLRLEVLAQREFAAPFDLSTDAPLRITM 162 Query 1140 LST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQ--RPSWAPLPVQYA-DYS 1195 + T ++ V+ LV HHIA D S V F DL AY G+ P +P A D + Sbjct 163 VHTGSDEYVMLLVAHHIAWDDGSWEVFFGDLTRAYAGEDLGEELEPHVPAVPRDAADDLA 222 Query 1196 VWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIR 1255 W+ + D + P G + TG+ L A Sbjct 223 YWRRVMADPPEPLELPGPTGSAVPTGWRSARTGV-------------------ALDADTA 263 Query 1256 DKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIV 1315 ++ ++R+ G T + +L A ++H+ D + PV R D+ IG++ N V Sbjct 264 RRVVDLARETGCTPYAVLLAVFGTLIHRYTHADDFLVATPVLNRGTGTEDR-IGYYGNTV 322 Query 1316 VLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVR 1375 +R + + R++L +TR AL A+AHQ + DQVV +NP R H Sbjct 323 AMRLRPTTSMSFRDMLIQTRDTALGAFAHQGVNVDQVVRELNPDRR-----------HGT 371 Query 1376 EQMPQDHVIDTGPD-------GDTTLRV-LEPTFDAAQADLSVNFFA--CGDEYRGHVIY 1425 E+M + GPD G R L + V F A G V + Sbjct 372 ERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHLTQLPLGVMVEFDAEPSGGGAVVEVEH 431 Query 1426 RTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 E+ E A AQ+ D V ++ + DRPD L + ++SA Sbjct 432 LVEIIEPALAQQLLDHFVVLLGSALDRPDTTLARLALMSA 471 >gi|108800432|ref|YP_640629.1| amino acid adenylation [Mycobacterium sp. MCS] gi|119869561|ref|YP_939513.1| amino acid adenylation domain-containing protein [Mycobacterium sp. KMS] gi|108770851|gb|ABG09573.1| Amino acid adenylation [Mycobacterium sp. MCS] gi|119695650|gb|ABL92723.1| amino acid adenylation domain [Mycobacterium sp. KMS] Length=1745 Score = 2295 bits (5948), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1202/1700 (71%), Positives = 1360/1700 (80%), Gaps = 32/1700 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ ADPSGALLN+CVSYRI G +DLA LR A++AVARRH +LRTTY D G +PT Sbjct 50 MWFVQAADPSGALLNVCVSYRIRGAVDLAALRGALDAVARRHPVLRTTYAADDTGAPRPT 109 Query 61 VHADLRPGWTQYDLTDL---SQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADE 117 VHADLRP W ++DLT L S++AQRLRLEVLAQREF APF+LS DAPLRIT+V T +DE Sbjct 110 VHADLRPAWAEHDLTGLANQSEQAQRLRLEVLAQREFAAPFDLSTDAPLRITMVHTGSDE 169 Query 118 HVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWR 177 +V+LLVAHHIAWDDGSW VFF DLT+AY+ G DLG E P A + P DL YWR Sbjct 170 YVMLLVAHHIAWDDGSWEVFFGDLTRAYA----GEDLGEELEPHAPAVPRDAADDLAYWR 225 Query 178 AIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAF 237 +MADPPEPLELPGP G+ VPT WR+AR + L ADTA RV +A+ TGCTPY VLLA F Sbjct 226 RVMADPPEPLELPGPTGSAVPTGWRSARTGVALDADTARRVVDLARETGCTPYAVLLAVF 285 Query 238 GALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIA 297 G L+HRYTH+DDFLVA PVLNRG GTED IGY+GNTVAMRLRP ++MSFR++L TRD A Sbjct 286 GTLIHRYTHADDFLVATPVLNRGTGTEDRIGYYGNTVAMRLRPTTSMSFRDMLIQTRDTA 345 Query 298 SGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNI 357 GAFAHQ +N+D+VVRELNPDRRHG ERMTRVSFGFR PD GF P G+ CER DLRS++ Sbjct 346 LGAFAHQGVNVDQVVRELNPDRRHGTERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHL 405 Query 358 TQLPLGFMVEFDR----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSG 413 TQLPLG MVEFD G +VE EHLVEI+EPALA+Q+L HF VLL +AL PD TL+ Sbjct 406 TQLPLGVMVEFDAEPSGGGAVVEVEHLVEIIEPALAQQLLDHFVVLLGSALDRPDTTLAR 465 Query 414 LALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEA 473 LALM DAA L +V+RG+ FDTP +TL DL+ Q TPD AV YEG+H+TY ++NE Sbjct 466 LALMSAADAAWLHDVARGDHFDTPPRTLPDLIAAQVATTPDEIAVAYEGRHYTYREINEQ 525 Query 474 SNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILA 533 +NR+ HWLI Q IG+EDRVAVLLDKSP+LIVTALGV K+GAVYVPVDP+YP+DRL FIL Sbjct 526 ANRVAHWLIGQSIGAEDRVAVLLDKSPELIVTALGVAKAGAVYVPVDPTYPEDRLAFILG 585 Query 534 DCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPV 593 DCDAKLVLR PV L G + DPTDADR+RPL P+NTAYLIYTSGTTGLPKGV V HRPV Sbjct 586 DCDAKLVLREPVSGLDGTPAHDPTDADRLRPLLPENTAYLIYTSGTTGLPKGVPVSHRPV 645 Query 594 AEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA 653 AEYFVWFK +Y VD DRLLQVASPSFDVSIAEIFG LACGAR+VI RPGGL DIGYLT Sbjct 646 AEYFVWFKADYQVDAKDRLLQVASPSFDVSIAEIFGMLACGARIVIHRPGGLNDIGYLTE 705 Query 654 LLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHN 713 LLRDE ITAMHFVPSLLGLFLSLPGV+QWRTLQRVPIGGEPLPGEVADKFHATFDALLHN Sbjct 706 LLRDERITAMHFVPSLLGLFLSLPGVNQWRTLQRVPIGGEPLPGEVADKFHATFDALLHN 765 Query 714 FYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTH 773 FYGPTETVINASR+KV G QGTRIVPIGRPKINT MHLLDD+LQPVP GVIGEIYIGGTH Sbjct 766 FYGPTETVINASRYKVEGKQGTRIVPIGRPKINTQMHLLDDALQPVPVGVIGEIYIGGTH 825 Query 774 VAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIE 833 VA+GYHRR GLTAERFVADPF PG R+YRSGDLARRNADGDIEFVGRADEQVKIRGFRIE Sbjct 826 VAHGYHRRPGLTAERFVADPFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIE 885 Query 834 LGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAA 893 LGDVAAAI+VDP+VGQAVV+VS+LP LGKSLVGY+TP +G D + V +DRIRARVAA Sbjct 886 LGDVAAAISVDPSVGQAVVMVSELPNLGKSLVGYLTPVSGEDRDS---VAVDRIRARVAA 942 Query 894 ALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELL 953 ALPEYM+PAAYVVLDE+PIT HGKIDRAALP P++ S +FR P T TER +A+LFGELL Sbjct 943 ALPEYMVPAAYVVLDEVPITTHGKIDRAALPAPELTSTADFREPGTDTEREMARLFGELL 1002 Query 954 GRD-RVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS 1012 GR +GADDSFFDLGGHSLLATKLVAAVR + GVD+GV+E+FE ATV LAGH+D L + Sbjct 1003 GRSANIGADDSFFDLGGHSLLATKLVAAVRTSCGVDIGVQEVFELATVAQLAGHVDALRA 1062 Query 1013 DS---ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAA 1069 ARPRL + DGP LSSSQ+RSWF YR DGP+ VNNIPFAA L GPCD +A Sbjct 1063 GGGGPARPRLMPLHLDGPAPLSSSQLRSWFAYRVDGPSVVNNIPFAARLRGPCDVDALVT 1122 Query 1070 AITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDL 1129 AI DVV RHEILRTVYREI GVPHQ++ PP V VR A G WLRAEL+ ER +VFDL Sbjct 1123 AIGDVVNRHEILRTVYREIDGVPHQVVLPPEPVTVRRAHGDGEEWLRAELDRERAHVFDL 1182 Query 1130 ETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 E D PIR A+L P+ VLS+V+HHIAGDHWSA VLF DLLTAYRAR+ G+ P+WAPLP+ Sbjct 1183 EQDRPIRPAVLRVPDGVVLSVVMHHIAGDHWSATVLFADLLTAYRARAAGEAPAWAPLPL 1242 Query 1190 QYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFR 1249 QYAD+ WQ+ALL D AGI GPQRDYW RQL GL ETGLRPDF RP + SG +AVEF Sbjct 1243 QYADFGAWQTALLADDAGIAGPQRDYWTRQLAGLPEETGLRPDFARPPVPSGRAEAVEFH 1302 Query 1250 LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIG 1309 + A RDKL A+ R+LGVTEFMLLQAAVAVVLHKAGGG DVP+G PVAGRSE LDQL+G Sbjct 1303 IDGATRDKLTALCRELGVTEFMLLQAAVAVVLHKAGGGPDVPLGTPVAGRSEPELDQLVG 1362 Query 1310 FFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFD 1369 FFINI+VLRNDLRGNPTLREV +R R+MAL AYAHQDLPFDQVV+AV+P R+L+RNPLF Sbjct 1363 FFINILVLRNDLRGNPTLREVCRRAREMALEAYAHQDLPFDQVVDAVSPVRTLARNPLFS 1422 Query 1370 IVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC--------GDEYRG 1421 +VVHVREQ+P+D VI GPDGDTT+ VLEPTFDAA ADLS+NFFA YRG Sbjct 1423 VVVHVREQLPEDRVIAHGPDGDTTVTVLEPTFDAAHADLSLNFFASERGVDGGFSSGYRG 1482 Query 1422 HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGT 1481 HVIYR ELY R TAQRF WL RVV AFAD+PD LR++E+ + +RRIL++ G Sbjct 1483 HVIYRPELYSRETAQRFVGWLGRVVTAFADQPDLTLRDLEIGAPGEQRRILEKWGGGG-- 1540 Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 V++LD+ L+PVPVGVVGDVY GGP A + TATRFVA P+ A G RL+R G Sbjct 1541 --VFVLDETLRPVPVGVVGDVYTAGGPLAAAHWGEAALTATRFVAHPYGADAGGRLHRTG 1598 Query 1542 ERGVWKADGQLELLAE--IERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYD 1599 ++ W ADG LEL+ + P +AA AEP T+TERALA +LADVL+V R+D Sbjct 1599 DQARWSADGVLELVGAEGLAAEPAVRAAGHTAEPPATDTERALATLLADVLDVEVTRRHD 1658 Query 1600 DFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHA 1659 DFF+LGGDSILA Q+AARARD G+ LTARMVFE P L +LAAAVDA D HA Sbjct 1659 DFFSLGGDSILAVQLAARARDAGLRLTARMVFEQPTLQDLAAAVDAAAETPGPAGDTAHA 1718 Query 1660 PMSTSGLSPDELSALTASWD 1679 PMS SGLS DEL+ALTASW+ Sbjct 1719 PMSASGLSADELAALTASWN 1738 Score = 111 bits (278), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 129/460 (29%), Positives = 191/460 (42%), Gaps = 55/460 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 LS Q R WF D A+ N+ + + G D A A+ V RH +LRT Y + Sbjct 43 LSEGQQRMWFVQAADPSGALLNVCVSYRIRGAVDLAALRGALDAVARRHPVLRTTYAADD 102 Query 1089 GGVP----HQIIQPP-AEVPVRCAAGS--DAAWLRAELNNERGYV--FDLETDWPIRAAL 1139 G P H ++P AE + A A LR E+ +R + FDL TD P+R + Sbjct 103 TGAPRPTVHADLRPAWAEHDLTGLANQSEQAQRLRLEVLAQREFAAPFDLSTDAPLRITM 162 Query 1140 LST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQ--RPSWAPLPVQYA-DYS 1195 + T ++ V+ LV HHIA D S V F DL AY G+ P +P A D + Sbjct 163 VHTGSDEYVMLLVAHHIAWDDGSWEVFFGDLTRAYAGEDLGEELEPHAPAVPRDAADDLA 222 Query 1196 VWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIR 1255 W+ + D + P G + TG+ L A Sbjct 223 YWRRVMADPPEPLELPGPTGSAVPTGWRSARTGV-------------------ALDADTA 263 Query 1256 DKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIV 1315 ++ ++R+ G T + +L A ++H+ D + PV R D+ IG++ N V Sbjct 264 RRVVDLARETGCTPYAVLLAVFGTLIHRYTHADDFLVATPVLNRGTGTEDR-IGYYGNTV 322 Query 1316 VLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVR 1375 +R + + R++L +TR AL A+AHQ + DQVV +NP R H Sbjct 323 AMRLRPTTSMSFRDMLIQTRDTALGAFAHQGVNVDQVVRELNPDRR-----------HGT 371 Query 1376 EQMPQDHVIDTGPD-------GDTTLRV-LEPTFDAAQADLSVNFFA--CGDEYRGHVIY 1425 E+M + GPD G R L + V F A G V + Sbjct 372 ERMTRVSFGFRGPDRFGFAPAGVHCERADLRSHLTQLPLGVMVEFDAEPSGGGAVVEVEH 431 Query 1426 RTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 E+ E A AQ+ D V ++ + DRPD L + ++SA Sbjct 432 LVEIIEPALAQQLLDHFVVLLGSALDRPDTTLARLALMSA 471 >gi|120404803|ref|YP_954632.1| amino acid adenylation domain-containing protein [Mycobacterium vanbaalenii PYR-1] gi|119957621|gb|ABM14626.1| amino acid adenylation domain [Mycobacterium vanbaalenii PYR-1] Length=1721 Score = 2195 bits (5687), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1141/1711 (67%), Positives = 1317/1711 (77%), Gaps = 76/1711 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-----PVGDDG 55 MWFV ADPSGALLN+C+SYR++G+ID+ARL DAV AVARRHR+LRTTY GD G Sbjct 50 MWFVHNADPSGALLNVCLSYRLSGEIDVARLHDAVGAVARRHRVLRTTYRTESTAAGDSG 109 Query 56 VAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAA 115 + PTVH L PGW ++DL++LS+RA+ LRLEVLAQREF PF+L ++PLRITV+RTA Sbjct 110 MPVPTVHTGLMPGWAEHDLSELSERARGLRLEVLAQREFGRPFDLGAESPLRITVIRTAP 169 Query 116 DEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNY 175 E+V+LLVAHHIAWDD SW VFF DLT AY +G L P RP A+G + E D+ Y Sbjct 170 AEYVMLLVAHHIAWDDASWEVFFDDLTGAY----VGEKLRPARRPVVAAG-GSDEDDVAY 224 Query 176 WRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLA 235 WRA+MADPPEPLELPGP G+ VPTSWR+ R TLRL +TA RV +A G TPY VLLA Sbjct 225 WRAVMADPPEPLELPGPTGSAVPTSWRSQRTTLRLDGETARRVTALADEVGATPYAVLLA 284 Query 236 AFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRD 295 FG L+HRY+H DDFLVA PVLNR T+D IGYFGNTVAMRLRP AM+FR+LLT TRD Sbjct 285 VFGVLIHRYSHVDDFLVATPVLNRNGDTDDVIGYFGNTVAMRLRPHPAMTFRDLLTQTRD 344 Query 296 IASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRS 355 A GAFAHQR+ LDR+VRELNPDRRHGAERMTRVSFGFR D GF PPG+ CER DLRS Sbjct 345 TALGAFAHQRVGLDRMVRELNPDRRHGAERMTRVSFGFRSRDRFGFTPPGVTCERADLRS 404 Query 356 NITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 ++T LPLG MVEFD V+VE EHLVEI+EP LA+Q+L H+ VL+ +AL PD TLSGL Sbjct 405 HLTHLPLGIMVEFDPDEVVVELEHLVEIIEPGLARQLLDHYAVLIRSALDDPDTTLSGLQ 464 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM + D LR VS G FDTP T+ DL+ Q R+PD TAVVYEG+H+TY ++NEA+N Sbjct 465 LMGDDDLEWLRAVSVGPTFDTPPATITDLIEAQVRRSPDGTAVVYEGRHYTYREINEAAN 524 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ HWLI + +G+EDRVAV+LDKSP+L+VTALGV+K+GAVYVP+DP+YPQDRL+FIL DC Sbjct 525 RVAHWLIGEDVGAEDRVAVMLDKSPELVVTALGVLKAGAVYVPIDPAYPQDRLEFILGDC 584 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAK+V+R PV L GYR+DDP D DR RP+ P NTAYLIYTSG+TGLPKGV VPHRPVAE Sbjct 585 DAKVVVREPVTGLDGYRADDPGDNDRRRPVGPYNTAYLIYTSGSTGLPKGVPVPHRPVAE 644 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWFKG+Y VD DR+LQVASPSFD+SIAE+FGTLACGAR+VI RPGGL DIGYLTALL Sbjct 645 YFVWFKGDYRVDAGDRMLQVASPSFDISIAEVFGTLACGARLVIHRPGGLNDIGYLTALL 704 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 RDEGITAMHFVPSLLGLFLSLPGV+QWRTLQRVPIGGE LPGEVADKF ATFDALLHNFY Sbjct 705 RDEGITAMHFVPSLLGLFLSLPGVNQWRTLQRVPIGGEALPGEVADKFRATFDALLHNFY 764 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETVINA+RFKV G QGTRIVPIG+PKINT +H+LDD+LQPVP G IGEIYIGGTHVA Sbjct 765 GPTETVINATRFKVEGRQGTRIVPIGKPKINTAIHILDDALQPVPVGSIGEIYIGGTHVA 824 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 GYH R GLTAERFVADPF PG+RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG Sbjct 825 RGYHHRPGLTAERFVADPFTPGARMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 884 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 DVAAAI VDP+VGQAVVVVSDLP LGKSLV Y+TPA G GVD+DRIR RVAAAL Sbjct 885 DVAAAITVDPSVGQAVVVVSDLPNLGKSLVAYLTPADGA------GVDVDRIRTRVAAAL 938 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 PEYM PAAYVV+DEIPITAHGKIDRAALPEP+IA TEFR P TE LAQLF ELLG Sbjct 939 PEYMTPAAYVVVDEIPITAHGKIDRAALPEPEIAPTTEFREPAAGTEAHLAQLFAELLGH 998 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS--- 1012 ++VGADDSFFDLGGHSLLATKLVA +R FGVDV VR+IFE AT+ LA H+DT+ Sbjct 999 EKVGADDSFFDLGGHSLLATKLVAELRAGFGVDVEVRDIFENATIARLAAHLDTMGRATI 1058 Query 1013 DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 + RPRL DGP LSSSQ+RSWF YR +G + VNNIPFAA L GPCD +AF AAI Sbjct 1059 GTRRPRLVAAPLDGPAPLSSSQLRSWFGYRIEGRSPVNNIPFAARLTGPCDVDAFVAAIR 1118 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETD 1132 DVV RH ILRT YREI GVP+QI+ P ++VPVR A G WL+AEL+ ER + FDLE D Sbjct 1119 DVVERHAILRTTYREIDGVPYQIVNPISDVPVRRARGEGEQWLQAELDRERKHTFDLEED 1178 Query 1133 WPIRAALLST-----------------------PEQTVLSLVVHHIAGDHWSAGVLFTDL 1169 WPIRAA+ + VLS+V+HHIAGDHWS GVLFTDL Sbjct 1179 WPIRAAVFTVGAVSPASDGGAVSPASDGGAVDPASDHVLSVVIHHIAGDHWSGGVLFTDL 1238 Query 1170 LTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGL 1229 + AYRAR G+RP+WAPLPVQY DY WQ+ LL D GI GPQR+YWIRQL E+GL Sbjct 1239 VAAYRARKAGERPTWAPLPVQYTDYGAWQAELLSDDTGIAGPQREYWIRQLADAPVESGL 1298 Query 1230 RPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVD 1289 +F RP L SG GDAVEF + +R ++ + R+LG+TEFMLLQAAVAV L K GGG+D Sbjct 1299 PLEFSRPRLPSGKGDAVEFTIDGQVRRQITELCRELGITEFMLLQAAVAVTLAKVGGGLD 1358 Query 1290 VPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPF 1349 +P+G PVAGRSEA L+QL+GFF+N VVLRNDLRGNPTLREVL R R+MAL+AY++QD+PF Sbjct 1359 IPLGTPVAGRSEAELEQLVGFFVNFVVLRNDLRGNPTLREVLIRAREMALSAYSNQDVPF 1418 Query 1350 DQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLS 1409 +QVVEAVNP R+L+RNPLF +VVHVREQ+PQ +IDT DT LEPTFD AQADLS Sbjct 1419 EQVVEAVNPPRTLARNPLFQVVVHVREQLPQRQMIDT----DTEFTALEPTFDIAQADLS 1474 Query 1410 VNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARR 1469 +NF A G YRG++IYR ELY R T +R WL RVV AF D PD+ L +V++VSA+ R+ Sbjct 1475 LNFLADGTGYRGYLIYRPELYARRTIERLGRWLPRVVAAFVDTPDRALGDVDIVSAEERQ 1534 Query 1470 RILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPF 1529 R+ + G ARV +LD L P PVGV GD+Y GG PF Sbjct 1535 RVSQEWSTG---ARVQVLDADLAPAPVGVFGDLYLSGG--------------------PF 1571 Query 1530 AAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAP--VPAEPADTETERALAAILA 1587 A + +R G+R W DG+LE+ A + AP V E T++ERALAA+L+ Sbjct 1572 AQR-----HRTGDRARWDDDGRLEIAARAPGATVVEVAPPAVEFEEPRTDSERALAALLS 1626 Query 1588 DVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKP 1647 ++L EVGR+DDFF LGGDS+LA Q+AARARD G+ LTARMVFEHP L ELAAA+D+ Sbjct 1627 ELLATEEVGRHDDFFGLGGDSVLAVQLAARARDTGLDLTARMVFEHPRLAELAAALDSGA 1686 Query 1648 HVEAEPDDKHHAPMSTSGLSPDELSALTASW 1678 AE D HHAPMS SGLS DEL+ALTASW Sbjct 1687 GAAAEQPDTHHAPMSVSGLSEDELAALTASW 1717 Score = 110 bits (274), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 101/348 (30%), Positives = 152/348 (44%), Gaps = 39/348 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI- 1088 L+ Q+R WF + D A+ N+ + L G D A+ V RH +LRT YR Sbjct 43 LTEGQLRMWFVHNADPSGALLNVCLSYRLSGEIDVARLHDAVGAVARRHRVLRTTYRTES 102 Query 1089 -----GGVP----HQIIQPPAEVPVRCAAGSDAAWLRAELNNER--GYVFDLETDWPIRA 1137 G+P H + P A LR E+ +R G FDL + P+R Sbjct 103 TAAGDSGMPVPTVHTGLMPGWAEHDLSELSERARGLRLEVLAQREFGRPFDLGAESPLRI 162 Query 1138 ALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARST--GQRPSWAPLPVQYADY 1194 ++ T P + V+ LV HHIA D S V F DL AY +RP A D Sbjct 163 TVIRTAPAEYVMLLVAHHIAWDDASWEVFFDDLTGAYVGEKLRPARRPVVAAGGSDEDDV 222 Query 1195 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1254 + W++ + D + + G A T R RL Sbjct 223 AYWRAVMADPPEPLE-------LPGPTGSAVPTSWR------------SQRTTLRLDGET 263 Query 1255 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1314 ++ A++ ++G T + +L A V++H+ D + PV R+ + D +IG+F N Sbjct 264 ARRVTALADEVGATPYAVLLAVFGVLIHRYSHVDDFLVATPVLNRN-GDTDDVIGYFGNT 322 Query 1315 VVLRNDLRGNP--TLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 V +R LR +P T R++L +TR AL A+AHQ + D++V +NP R Sbjct 323 VAMR--LRPHPAMTFRDLLTQTRDTALGAFAHQRVGLDRMVRELNPDR 368 >gi|289762546|ref|ZP_06521924.1| peptide synthetase mbtE [Mycobacterium tuberculosis GM 1503] gi|289710052|gb|EFD74068.1| peptide synthetase mbtE [Mycobacterium tuberculosis GM 1503] Length=1288 Score = 2120 bits (5494), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1075/1099 (98%), Positives = 1078/1099 (99%), Gaps = 4/1099 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 50 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 109 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 110 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 169 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 170 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 229 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 230 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 289 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 290 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 349 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 350 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 409 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 410 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 469 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 470 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 529 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 530 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 589 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 590 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 649 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 650 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 709 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 710 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 769 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 770 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 829 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 830 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 889 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 890 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 949 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 950 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 1009 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1020 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT Sbjct 1010 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLT 1069 Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 RVDHDGPVRLSSSQMRS +YR + + GP N FAAAITDVVARHEI Sbjct 1070 RVDHDGPVRLSSSQMRSC-HYRSTAQRVTHP---SRICMGPVTPNEFAAAITDVVARHEI 1125 Query 1081 LRTVYREIGGVPHQIIQPP 1099 LRTVYREIGGVPHQIIQPP Sbjct 1126 LRTVYREIGGVPHQIIQPP 1144 Score = 114 bits (286), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 106/350 (31%), Positives = 151/350 (44%), Gaps = 41/350 (11%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 RLS Q R WF D A+ NI + + G D A+ V RH ILRT Y + Sbjct 42 RLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PV 100 Query 1089 GGVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAA 1138 G + QP +R A LR E+ +R + F+L D P+R Sbjct 101 GD--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRIT 158 Query 1139 LLSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQ 1190 ++ T ++ VL LV HHIA D S V FTDL AY G RPS A P Sbjct 159 VVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT 218 Query 1191 YADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRL 1250 AD + W++ + D + + G T R RL Sbjct 219 EADLNYWRAIMADPPEPLE-------LPGPAGTCVPTSWR------------AARATLRL 259 Query 1251 GAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGF 1310 A ++A ++++ G T +M+L AA ++H+ D + APV R A + IG+ Sbjct 260 PADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGY 318 Query 1311 FINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 F N V +R + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 319 FGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 368 Score = 69.7 bits (169), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 35/76 (47%), Positives = 48/76 (64%), Gaps = 2/76 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 ++LLDD+L+PVP GV+G++Y GG R TA RFVADPF PGSR+YR+G+ Sbjct 798 MHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDL 855 Query 1544 GVWKADGQLELLAEIE 1559 ADG +E + + Sbjct 856 ARRNADGDIEFVGRAD 871 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/96 (37%), Positives = 49/96 (52%), Gaps = 8/96 (8%) Query 1566 AAPVPAEPADTE-------TERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 1618 A P P +DTE TER LA + ++L VG D FF+LGG S+LAT++ A Sbjct 971 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAV 1030 Query 1619 RDG-GIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 1653 R+ G+ + R +FE + LA +D A P Sbjct 1031 RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 1066 >gi|118470602|ref|YP_888783.1| linear gramicidin synthetase subunit B [Mycobacterium smegmatis str. MC2 155] gi|118171889|gb|ABK72785.1| linear gramicidin synthetase subunit B [Mycobacterium smegmatis str. MC2 155] Length=1819 Score = 2080 bits (5389), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1058/1588 (67%), Positives = 1240/1588 (79%), Gaps = 38/1588 (2%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DPSG LLN+ +SYR+TGDID R++ AV AVARRH ILRTT+ ++G + Sbjct 55 MWFVQGFDPSGVLLNVSLSYRLTGDIDAERMQAAVEAVARRHPILRTTFHADENGEPRAE 114 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VH DL P WT +DL++ S+RA++LRLEVLAQREF PF+L ++PLR+T++RT EHVL Sbjct 115 VHDDLTPSWTTHDLSEKSERARKLRLEVLAQREFGTPFDLGTESPLRLTLIRTGPAEHVL 174 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLT+AYS L PE A+ PDTT+ DL YWR +M Sbjct 175 LLVAHHIAWDDGSWRVFFTDLTRAYSGEQL-----PETPRVGAAAPDTTDEDLAYWREVM 229 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 A+PPEPLELPGP G+ VPT +R+ R+T+RL A+T +V +A+ TG TPYMVLLAAFGAL Sbjct 230 ANPPEPLELPGPMGSVVPTGFRSQRSTVRLSAETVEKVTVLARETGATPYMVLLAAFGAL 289 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 + RYTH+DDFLVA PVLNR TED IGY GNTVAMR+RP+S FR+L+ TRD+A GA Sbjct 290 IRRYTHTDDFLVATPVLNRD--TEDTIGYHGNTVAMRMRPRSDAGFRDLVLQTRDVALGA 347 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQR+NLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGF P G+ CER +LR N TQL Sbjct 348 FAHQRVNLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFCPAGVRCERAELRGNHTQL 407 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVE++ G VEAEHL E+L+ ALA+QMLRHF VLLDNALA PD L L L Sbjct 408 PLGFMVEWEATGATVEAEHLTEVLDAALAEQMLRHFTVLLDNALADPDRALWRLDLFTAE 467 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 D A L ++ GE FDTP TL DLV +Q RTPDATAVVYEG+HFTY ++NE++NRL HW Sbjct 468 DTAWLTRMATGEAFDTPAATLTDLVTQQAERTPDATAVVYEGRHFTYREINESANRLAHW 527 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LI QGIG+EDRVAVLL+KSP+L++TALG+VK+GAVY+PVDP+YP+DRL++IL+D D K+V Sbjct 528 LIGQGIGTEDRVAVLLEKSPELVITALGIVKAGAVYLPVDPTYPEDRLNYILSDSDPKIV 587 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LR V L + DPTDA+R+RPLRPDNTAYLIYTSG+TGLPKGV VPHRP+AEYFVWF Sbjct 588 LREFVTGLDDQPTTDPTDAERVRPLRPDNTAYLIYTSGSTGLPKGVPVPHRPIAEYFVWF 647 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 GEYDV + DRLLQVAS SFDVSI EIFG LA GAR+VIP+PGGLTDIGYLT LLR+EGI Sbjct 648 GGEYDVTNEDRLLQVASQSFDVSIGEIFGMLAAGARLVIPKPGGLTDIGYLTDLLRNEGI 707 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 T+MHFVPSLLGLFLSLPGV++WRTLQRVPIGGE LPGE+ADKFHATFD+LLHNFYGPTET Sbjct 708 TSMHFVPSLLGLFLSLPGVNEWRTLQRVPIGGEALPGEIADKFHATFDSLLHNFYGPTET 767 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 V+N +R+KV G QG R VPIG+PKINTT+HLLDD+LQPVP GVIGEIYIGGTHVA+GYHR Sbjct 768 VLNCTRYKVEGKQGARTVPIGKPKINTTIHLLDDALQPVPVGVIGEIYIGGTHVAHGYHR 827 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 R G+TAERFVADPFNPG RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG+V+AA Sbjct 828 RPGMTAERFVADPFNPGGRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGEVSAA 887 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 I+VDP+VGQAVVVVSDLP LGKSLV Y+TPAAG D VD++RIRARV AALPEYM+ Sbjct 888 ISVDPSVGQAVVVVSDLPSLGKSLVAYITPAAGAD-----HVDIERIRARVTAALPEYMV 942 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYV LDEIPIT HGKIDR ALPEP+I S T FR P T TER +A LF ELL RD VGA Sbjct 943 PAAYVELDEIPITTHGKIDRRALPEPEITSTTRFREPSTDTERTVAGLFAELLERDEVGA 1002 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTL---DSDSARP 1017 DDSFFDLGGHSLLATKLVAAVR VDVGV+++FE ATV+ LA HI+ L + S RP Sbjct 1003 DDSFFDLGGHSLLATKLVAAVRARCAVDVGVQDVFEHATVSGLAAHIEDLVASGASSGRP 1062 Query 1018 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1077 + V HDGP+++S++Q+R WF +R DGPN VNN+PFAA L GPCD +A AA+ DVVAR Sbjct 1063 AIVAVPHDGPLQMSAAQLRQWFQFRIDGPNPVNNVPFAARLSGPCDVDALIAAVGDVVAR 1122 Query 1078 HEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRA 1137 HEILRT YREI G P+QII PPA VPVR A G W++A+L+ ER Y FDLETDWPIRA Sbjct 1123 HEILRTTYREIDGAPYQIIHPPAPVPVRQARGDGEDWVQAQLDAERRYCFDLETDWPIRA 1182 Query 1138 ALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVW 1197 A+L+T E VLSLVVHHIA DHWS VLFTDLLTAY AR G PLPVQYAD++ W Sbjct 1183 AVLTTAEHHVLSLVVHHIAADHWSGTVLFTDLLTAYHARHAGSAVELPPLPVQYADFAAW 1242 Query 1198 QSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDK 1257 Q+ LL + QR YW QL GL E GL PDFPRP + +G G A++F + A R + Sbjct 1243 QAELLAGTDDTIDEQRRYWTTQLAGLPEENGLYPDFPRPPVPTGDGAALDFSIDADTRAR 1302 Query 1258 LAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVL 1317 L A++R+LGVTEFMLLQAAVA+ LHK+G G D+P+G PVAGR+ LD LIGFFINIVVL Sbjct 1303 LIALTRELGVTEFMLLQAAVAIALHKSGQGTDIPLGTPVAGRTAPELDALIGFFINIVVL 1362 Query 1318 RNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ 1377 RNDL GNP+LREVL+R+R+MALAAY HQDLPFD+VV+AV+P RSLSRNPLF +VVHVR+ Sbjct 1363 RNDLSGNPSLREVLRRSREMALAAYQHQDLPFDRVVDAVSPVRSLSRNPLFGVVVHVRDD 1422 Query 1378 MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDE---------YRGHVIYRTE 1428 +P D VID G +G+T LEPTFD A ADLS+NFFA Y+G VIYRTE Sbjct 1423 LPADQVIDDGGNGETRFTALEPTFDVAHADLSLNFFAQNGNGGRAGEPAGYKGTVIYRTE 1482 Query 1429 LYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGA--------- 1479 LYE ATA+R WL R+++AFA D LR++ ++ A R +++ + A Sbjct 1483 LYEPATARRLIGWLHRIIDAFATDADTTLRDIAVIDADERTLLIEDWSRRAVPPALPQTE 1542 Query 1480 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYR 1539 G VY+LD+ L+PV +GV+GDVYY GG + A A RFV +PF A RLYR Sbjct 1543 GATNVYVLDEWLEPVAIGVIGDVYYAGGAVDASAEAANGVAAQRFVPNPFGA---GRLYR 1599 Query 1540 NGERGVWKADGQLELLAEIERLPTAQAA 1567 G+R W DG+LE + E P QAA Sbjct 1600 TGDRARWTPDGRLEPVTAGE--PRLQAA 1625 Score = 138 bits (347), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 76/125 (61%), Positives = 90/125 (72%), Gaps = 1/125 (0%) Query 1556 AEIERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVA 1615 A + R + A P E T TERA+AA+L ++L V +VGR+DDFF LGGDSILA Q+A Sbjct 1690 AALTRPRVSATASGPFEAPATPTERAVAAMLVELLGVTQVGRHDDFFTLGGDSILAVQLA 1749 Query 1616 ARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALT 1675 ARARD G+ +TARMVFEHPVL ELAAA+DA A D HHAPM SGLS DEL+ALT Sbjct 1750 ARARDAGVAMTARMVFEHPVLSELAAAIDAAGEGSAA-QDVHHAPMEASGLSSDELAALT 1808 Query 1676 ASWDQ 1680 A+W Q Sbjct 1809 AAWGQ 1813 Score = 116 bits (290), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 135/485 (28%), Positives = 197/485 (41%), Gaps = 73/485 (15%) Query 1027 PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR 1086 P LS Q R WF FD + N+ + L G D AA+ V RH ILRT + Sbjct 45 PTVLSDGQRRMWFVQGFDPSGVLLNVSLSYRLTGDIDAERMQAAVEAVARRHPILRTTFH 104 Query 1087 -EIGGVP----HQIIQPPAEVPVRCAAGSDAAWLRAELNNER--GYVFDLETDWPIRAAL 1139 + G P H + P A LR E+ +R G FDL T+ P+R L Sbjct 105 ADENGEPRAEVHDDLTPSWTTHDLSEKSERARKLRLEVLAQREFGTPFDLGTESPLRLTL 164 Query 1140 LST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRP--SWAPLPVQYADYSV 1196 + T P + VL LV HHIA D S V FTDL AY + P A D + Sbjct 165 IRTGPAEHVLLLVAHHIAWDDGSWRVFFTDLTRAYSGEQLPETPRVGAAAPDTTDEDLAY 224 Query 1197 WQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRD 1256 W+ + + + + G TG R RL A + Sbjct 225 WREVMANPPEPLE-------LPGPMGSVVPTGFR------------SQRSTVRLSAETVE 265 Query 1257 KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVV 1316 K+ ++R+ G T +M+L AA ++ + D + PV R + + IG+ N V Sbjct 266 KVTVLARETGATPYMVLLAAFGALIRRYTHTDDFLVATPVLNR---DTEDTIGYHGNTVA 322 Query 1317 LRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE 1376 +R R + R+++ +TR +AL A+AHQ + D+VV +NP R + + RE Sbjct 323 MRMRPRSDAGFRDLVLQTRDVALGAFAHQRVNLDRVVRELNPDRRHGAERMTRVSFGFRE 382 Query 1377 -----------------------QMPQDHVIDTGPDGDTT-LRVLEPTFDAAQADLSVNF 1412 Q+P +++ G T L DAA A+ + Sbjct 383 PDGGGFCPAGVRCERAELRGNHTQLPLGFMVEWEATGATVEAEHLTEVLDAALAEQMLRH 442 Query 1413 F------ACGDEYRGHVIYRTELYERATAQRFADWLVRVV--EAFADRPDQPLREVEMVS 1464 F A D R ++R +L+ TA+ A WL R+ EAF D P L ++V+ Sbjct 443 FTVLLDNALADPDRA--LWRLDLF---TAEDTA-WLTRMATGEAF-DTPAATL--TDLVT 493 Query 1465 AQARR 1469 QA R Sbjct 494 QQAER 498 Score = 105 bits (261), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 103/322 (32%), Positives = 147/322 (46%), Gaps = 40/322 (12%) Query 699 VADKFHATFDALLHNFYGPTETVINA-SRFKVVGPQGTRIVPIGRPKIN--TTMHLLDDS 755 + D F D L + VI+A R ++ R VP P+ T +++LD+ Sbjct 1499 IIDAFATDADTTLRDI-----AVIDADERTLLIEDWSRRAVPPALPQTEGATNVYVLDEW 1553 Query 756 LQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDI 815 L+PV GVIG++Y G V G+ A+RFV +PF G R+YR+GD AR DG + Sbjct 1554 LEPVAIGVIGDVYYAGGAVDASAEAANGVAAQRFVPNPFGAG-RLYRTGDRARWTPDGRL 1612 Query 816 EFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGD 875 E V + +++ AA AVD G A L+ A Sbjct 1613 EPVTAGEPRLQ-----------AALEAVD---GVAAAATRYWENRSAPLLAAYVVADA-- 1656 Query 876 GPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTE-- 933 + +V ALP+ AA V+D++ AAL P++++ Sbjct 1657 ----AHAADPQFAEQVRTALPDEFAGAAITVVDDL--------TPAALTRPRVSATASGP 1704 Query 934 FRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVRE 993 F AP T TER +A + ELLG +VG D FF LGG S+LA +L A R+A GV + R Sbjct 1705 FEAPATPTERAVAAMLVELLGVTQVGRHDDFFTLGGDSILAVQLAARARDA-GVAMTARM 1763 Query 994 IFEFATVTALAGHIDTLDSDSA 1015 +FE ++ LA ID SA Sbjct 1764 VFEHPVLSELAAAIDAAGEGSA 1785 Score = 54.7 bits (130), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/104 (39%), Positives = 59/104 (57%), Gaps = 16/104 (15%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQV--AARARDGGIPLTARM 1629 EP+ T+TER +A + A++LE EVG D FF+LGG S+LAT++ A RAR + + + Sbjct 978 EPS-TDTERTVAGLFAELLERDEVGADDSFFDLGGHSLLATKLVAAVRAR-CAVDVGVQD 1035 Query 1630 VFEHPVLCELAAAVD---------AKPHVEAEPDDKHHAPMSTS 1664 VFEH + LAA ++ +P + A P H P+ S Sbjct 1036 VFEHATVSGLAAHIEDLVASGASSGRPAIVAVP---HDGPLQMS 1076 >gi|315443743|ref|YP_004076622.1| amino acid adenylation enzyme/thioester reductase family protein [Mycobacterium sp. Spyr1] gi|315262046|gb|ADT98787.1| amino acid adenylation enzyme/thioester reductase family protein [Mycobacterium sp. Spyr1] Length=1762 Score = 2023 bits (5242), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1018/1563 (66%), Positives = 1206/1563 (78%), Gaps = 55/1563 (3%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFV DPSG LLN+C+SYRI+G++DLARL DAV AVARRH +LRTT+ + G Q T Sbjct 50 MWFVHSVDPSGVLLNVCLSYRISGEVDLARLHDAVTAVARRHPVLRTTFAADEAGEPQRT 109 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VH DL PGWT D+++LS+ A+RLRLEVLAQREF PF+L+ ++PLRITV RTA E+++ Sbjct 110 VHDDLLPGWTVQDISELSEHARRLRLEVLAQREFGTPFDLATESPLRITVARTAPAEYIM 169 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLV HHIAWDDG WRVFF DLT+AY+ GA+LGP P+ P T++ DL +WR+ M Sbjct 170 LLVVHHIAWDDGCWRVFFADLTRAYT----GAELGPT--PAPVVEPPTSDEDLRFWRSAM 223 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 D PEPLELPGP G+ VPT+WR R T L ADT RV A+ G TPYMV+LAAFGAL Sbjct 224 TDLPEPLELPGPHGSAVPTTWRCRRVTATLSADTVERVRVAAREAGATPYMVMLAAFGAL 283 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 +HRYTH+DD L+A+PVL RG +ED IGY GN+ MRLRPQ +F ELL+ TRD A A Sbjct 284 LHRYTHADDVLIASPVLLRGPDSEDVIGYHGNSAVMRLRPQPMQTFTELLSRTRDFALDA 343 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQ++NLDRVVRELN DRRHGAERMTRVSFGFREPDGGGF+PPG+ C R +LR ITQL Sbjct 344 FAHQQVNLDRVVRELNLDRRHGAERMTRVSFGFREPDGGGFSPPGVTCRRAELRGQITQL 403 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLG MVE +G +VEAE LVE+L+ L QML H+ VLL+ A+A PD LS L LMD Sbjct 404 PLGLMVELHESGAVVEAEFLVEVLDDTLVTQMLDHYVVLLEAAVAQPDTVLSRLELMDGD 463 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DA LR VS G FD P T+ +L+ +T TPD AVVYEG+ +TY ++NE++NR+ HW Sbjct 464 DAEWLRRVSHGPEFDVPAATIGELIEARTDLTPDTVAVVYEGRRYTYREINESANRVAHW 523 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LI QGIG+EDRVAVL+D+SP+L++TALG++K+GAVY+PVDPSYPQDR+ F+L+D D LV Sbjct 524 LIGQGIGAEDRVAVLMDRSPELLITALGIIKAGAVYLPVDPSYPQDRMSFVLSDSDPTLV 583 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 +R PV L G+R+D+PTD R+RPLRP+N AYLIYTSG+TG PKGV VPHRPVAEYFVWF Sbjct 584 IREPVAGLDGHRTDNPTDDVRVRPLRPENAAYLIYTSGSTGQPKGVPVPHRPVAEYFVWF 643 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 K EY++ ++DRLLQVASPSFDVSI EIFGTLACG R+VIP+P GLTD+ YLT LL+ EGI Sbjct 644 KDEYEISESDRLLQVASPSFDVSIGEIFGTLACGGRLVIPKPDGLTDVAYLTELLQREGI 703 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGV+QWRTL+RVPIGGE LPGE+AD+FHATFDALLHNFYGPTET Sbjct 704 TAMHFVPSLLGLFLSLPGVNQWRTLERVPIGGEALPGELADRFHATFDALLHNFYGPTET 763 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 +IN +R+KV G QG+RIVPIG PKINTT+HLLDD+L+PVP G IGEIYIGG HVA GYHR Sbjct 764 IINTTRYKVEGTQGSRIVPIGTPKINTTVHLLDDALRPVPVGAIGEIYIGGGHVARGYHR 823 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 R LTAERFVADPF G R+YRSGDLARRNADGD+EFVGRAD+QVKIRGFRIELG+VAAA Sbjct 824 RPALTAERFVADPFTVGGRLYRSGDLARRNADGDLEFVGRADDQVKIRGFRIELGEVAAA 883 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 I+VDP+VGQAVV+ DLP LG SLVGYVTPAAG D VDL R+R RVAAALP+YM Sbjct 884 ISVDPSVGQAVVLGQDLPGLGMSLVGYVTPAAGED------VDLARVRERVAAALPDYMT 937 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PA YVVLDEIPITAHGKIDRAALP P+I + T++R PQT TE+ LAQLF ELLG RVG Sbjct 938 PAGYVVLDEIPITAHGKIDRAALPLPEITTATDYREPQTETEQHLAQLFSELLGVARVGV 997 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSA---RP 1017 DDSFF+LGGHSLLATKLV+AVR+ GVD+ +REIFE TV LA +D L + + RP Sbjct 998 DDSFFELGGHSLLATKLVSAVRSRCGVDMEIREIFELGTVARLAERVDELAAGGSAPLRP 1057 Query 1018 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1077 RL V HDGP +S++Q+R WF YR +GP VNN+PFAA GPCD +A A+ DVV R Sbjct 1058 RLLAVPHDGPAPMSAAQLRQWFQYRIEGPGPVNNVPFAARFAGPCDVDALIEAVRDVVNR 1117 Query 1078 HEILRTVYREIGGVPHQIIQPP-AEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIR 1136 HE LRT + EI GVP+Q++ P PVR +G D AWL L++ER VFDLE WPIR Sbjct 1118 HESLRTTFCEIDGVPYQLVNAPDPGFPVRRDSGPDDAWLVGALDDERRRVFDLENQWPIR 1177 Query 1137 AALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSV 1196 A+LS P + LS+VVHHIA DHWS GVLFT+LLTAYRAR G+ P+WAPLPVQYADY+ Sbjct 1178 VAVLSIPGEHALSVVVHHIAADHWSGGVLFTELLTAYRARRAGEAPTWAPLPVQYADYAA 1237 Query 1197 WQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRD 1256 WQSALL D +GIV QR YW +QL GL+ ETGL+PD RP++ SGA DAVEF L A IR+ Sbjct 1238 WQSALLADDSGIVAAQRRYWTQQLEGLSAETGLQPDLVRPSVPSGAADAVEFTLDAGIRE 1297 Query 1257 KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVV 1316 KL +SR++G TEFMLLQAAVAV L+KAG G D+P+G PVAGR+E+ LDQLIGFFINI+V Sbjct 1298 KLVTLSREVGATEFMLLQAAVAVTLYKAGEGPDIPLGTPVAGRTESELDQLIGFFINILV 1357 Query 1317 LRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE 1376 LRNDLR NP+LR+V R+R+MALAAYAHQDLPFDQVV+AV+P RSLSRNPLF +VVHVR+ Sbjct 1358 LRNDLRDNPSLRDVGFRSREMALAAYAHQDLPFDQVVDAVSPVRSLSRNPLFGVVVHVRD 1417 Query 1377 QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQ 1436 ++PQD VI TGPDG+TT LEPTFD A ADLSVNFFA + YRGHVIYRTELY RATA+ Sbjct 1418 ELPQDRVIATGPDGETTFTALEPTFDMAHADLSVNFFAGENGYRGHVIYRTELYTRATAE 1477 Query 1437 RFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPV 1496 RFA WL V+ AFAD P++ R ++V A+ R GAG A LLD A PVPV Sbjct 1478 RFAGWLSAVITAFADDPER--RVDDVVIAEPVR-------PGAG-AEAVLLDGAGHPVPV 1527 Query 1497 GVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLA 1556 GVV DV+Y G P R G+R W DG+L+ + Sbjct 1528 GVVADVHYTGAPD-----------------------------RRGDRARWTEDGRLQYVE 1558 Query 1557 EIE 1559 ++ Sbjct 1559 RVD 1561 Score = 115 bits (289), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 63/113 (56%), Positives = 82/113 (73%), Gaps = 6/113 (5%) Query 1570 PAEPADTETERALAAILADVL-EVGE---VGRYDDFFNLGGDSILATQVAARARDGGIPL 1625 P+EPA T+TE+AL +LADVL E+ + +GR+DDFF LGGDSILA Q+AARA+ G+ L Sbjct 1644 PSEPARTDTEKALVGMLADVLVELHDGTGIGRFDDFFELGGDSILAVQLAARAKQAGLRL 1703 Query 1626 TARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASW 1678 +ARMVFEHPV+ +LA A+D E D H PMS SGL+P+EL+ + SW Sbjct 1704 SARMVFEHPVVHDLAVALDTAKTPEVA--DVRHDPMSASGLTPEELAMVATSW 1754 Score = 112 bits (279), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 108/346 (32%), Positives = 155/346 (45%), Gaps = 41/346 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 + Q R WF + D + N+ + + G D A+T V RH +LRT + + Sbjct 43 FTDGQKRMWFVHSVDPSGVLLNVCLSYRISGEVDLARLHDAVTAVARRHPVLRTTFAADE 102 Query 1089 GGVPHQIIQ----PPAEVPVRCAAGSDAAWLRAELNNER--GYVFDLETDWPIRAALLST 1142 G P + + P V A LR E+ +R G FDL T+ P+R + T Sbjct 103 AGEPQRTVHDDLLPGWTVQDISELSEHARRLRLEVLAQREFGTPFDLATESPLRITVART 162 Query 1143 -PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPL---PVQYADYSVWQ 1198 P + ++ LVVHHIA D V F DL AY G P+ AP+ P D W+ Sbjct 163 APAEYIMLLVVHHIAWDDGCWRVFFADLTRAYTGAELG--PTPAPVVEPPTSDEDLRFWR 220 Query 1199 SALLD--DGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRD 1256 SA+ D + + GP G A T R R + + D VE Sbjct 221 SAMTDLPEPLELPGPH---------GSAVPTTWR---CRRVTATLSADTVE--------- 259 Query 1257 KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVV 1316 ++ +R+ G T +M++ AA +LH+ DV I +PV R + D +IG+ N V Sbjct 260 RVRVAAREAGATPYMVMLAAFGALLHRYTHADDVLIASPVLLRGPDSED-VIGYHGNSAV 318 Query 1317 LRNDLRGNP--TLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 +R LR P T E+L RTR AL A+AHQ + D+VV +N R Sbjct 319 MR--LRPQPMQTFTELLSRTRDFALDAFAHQQVNLDRVVRELNLDR 362 Score = 67.8 bits (164), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 84/288 (30%), Positives = 119/288 (42%), Gaps = 64/288 (22%) Query 742 RPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMY 801 RP LLD + PVP GV+ +++ G Sbjct 1508 RPGAGAEAVLLDGAGHPVPVGVVADVHYTGAP---------------------------D 1540 Query 802 RSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLG 861 R GD AR DG +++V R D ++ + AA + +G VV Sbjct 1541 RRGDRARWTEDGRLQYVERVDHDLEAALAAVPGVAAAAVRTWE--IGHRTAVV------- 1591 Query 862 KSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRA 921 GYV P+ D PA + +RA VA PE P + VLD +P T R Sbjct 1592 ----GYVVPSEPVDDPASFA---ETVRAAVA---PESA-PTSITVLDALPAT------RR 1634 Query 922 ALPEPQIASDTEFRAPQTATER----RLAQLFGELLGRDRVGADDSFFDLGGHSLLATKL 977 ALP P++ +E +T TE+ LA + EL +G D FF+LGG S+LA +L Sbjct 1635 ALPAPRVGGPSE--PARTDTEKALVGMLADVLVELHDGTGIGRFDDFFELGGDSILAVQL 1692 Query 978 VAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHD 1025 A + A G+ + R +FE V LA +DT + P + V HD Sbjct 1693 AARAKQA-GLRLSARMVFEHPVVHDLAVALDTAKT----PEVADVRHD 1735 Score = 53.1 bits (126), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/116 (38%), Positives = 59/116 (51%), Gaps = 12/116 (10%) Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LP A EP TETE+ LA + +++L V VG D FF LGG S+LAT++ + R Sbjct 962 LPEITTATDYREP-QTETEQHLAQLFSELLGVARVGVDDSFFELGGHSLLATKLVSAVRS 1020 Query 1621 -GGIPLTARMVFEHPVLCELAAAVDA---------KPHVEAEPDDKHHAPMSTSGL 1666 G+ + R +FE + LA VD +P + A P D APMS + L Sbjct 1021 RCGVDMEIREIFELGTVARLAERVDELAAGGSAPLRPRLLAVPHDG-PAPMSAAQL 1075 >gi|145223283|ref|YP_001133961.1| amino acid adenylation domain-containing protein [Mycobacterium gilvum PYR-GCK] gi|145215769|gb|ABP45173.1| amino acid adenylation domain [Mycobacterium gilvum PYR-GCK] Length=1762 Score = 2023 bits (5240), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1019/1563 (66%), Positives = 1206/1563 (78%), Gaps = 55/1563 (3%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFV DPSG LLN+C+SYRI+G++DLARL DAV AVARRH +LRTT+ + G Q T Sbjct 50 MWFVHSVDPSGVLLNVCLSYRISGEVDLARLHDAVTAVARRHPVLRTTFAADEAGEPQRT 109 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VH DL PGWT D+++LS+ A+RLRLEVLAQREF PF+L+ ++PLRITV RTA E+++ Sbjct 110 VHDDLLPGWTVQDISELSEHARRLRLEVLAQREFGTPFDLATESPLRITVARTAPAEYIM 169 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLV HHIAWDDG WRVFF DLT+AY+ GA+LGP P+ P T++ DL +WR+ M Sbjct 170 LLVVHHIAWDDGCWRVFFADLTRAYT----GAELGPT--PAPVVEPPTSDEDLRFWRSAM 223 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 D PEPLELPGP G+ VPT+WR R T L ADT RV A+ G TPYMV+LAAFGAL Sbjct 224 TDLPEPLELPGPHGSAVPTTWRCRRVTATLSADTVERVRVAAREAGATPYMVMLAAFGAL 283 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 +HRYTH+DD L+A+PVL RG +ED IGY GN+ MRLRPQ +F ELL+ TRD A A Sbjct 284 LHRYTHADDVLIASPVLLRGPDSEDVIGYHGNSAVMRLRPQPMQTFTELLSRTRDFALDA 343 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQ++NLDRVVRELN DRRHGAERMTRVSFGFREPDGGGF+PPG+ C R +LR ITQL Sbjct 344 FAHQQVNLDRVVRELNLDRRHGAERMTRVSFGFREPDGGGFSPPGVTCRRAELRGQITQL 403 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLG MVE +G +VEAE LVE+L+ L QML H+ VLL+ A+A PD LS L LMD Sbjct 404 PLGLMVELHESGAVVEAEFLVEVLDDTLVTQMLDHYVVLLEAAVAQPDTVLSRLELMDGD 463 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DA LR VS G FD P T+ +L+ +T TPD AVVYEG+ +TY ++NE++NR+ HW Sbjct 464 DAEWLRRVSHGPEFDVPAATIGELIEARTDLTPDTVAVVYEGRRYTYREINESANRVAHW 523 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LI QGIG+EDRVAVL+D+SP+L++TALG++K+GAVY+PVDPSYPQDR+ F+L+D D LV Sbjct 524 LIGQGIGAEDRVAVLMDRSPELLITALGIIKAGAVYLPVDPSYPQDRMSFVLSDSDPTLV 583 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 +R PV L G+R+D+PTD R+RPLRP+N AYLIYTSG+TG PKGV VPHRPVAEYFVWF Sbjct 584 IREPVAGLDGHRTDNPTDDVRVRPLRPENAAYLIYTSGSTGQPKGVPVPHRPVAEYFVWF 643 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 K EY++ ++DRLLQVASPSFDVSI EIFGTLACG R+VIP+P GLTD+ YLT LL+ EGI Sbjct 644 KDEYEISESDRLLQVASPSFDVSIGEIFGTLACGGRLVIPKPDGLTDVAYLTELLQREGI 703 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGV+QWRTL+RVPIGGE LPGE+AD+FHATFDALLHNFYGPTET Sbjct 704 TAMHFVPSLLGLFLSLPGVNQWRTLERVPIGGEALPGELADRFHATFDALLHNFYGPTET 763 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 +IN +R+KV G QG+RIVPIG PKINTT+HLLDD+L+PVP G IGEIYIGG HVA GYHR Sbjct 764 IINTTRYKVEGTQGSRIVPIGTPKINTTVHLLDDALRPVPVGAIGEIYIGGGHVARGYHR 823 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 R LTAERFVADPF G R+YRSGDLARRNADGD+EFVGRAD+QVKIRGFRIELG+VAAA Sbjct 824 RPALTAERFVADPFTVGGRLYRSGDLARRNADGDLEFVGRADDQVKIRGFRIELGEVAAA 883 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 I+VDP+VGQAVV+ DLP LG SLVGYVTPAAG D VDL R+R RVAAALP+YM Sbjct 884 ISVDPSVGQAVVLGQDLPGLGMSLVGYVTPAAGED------VDLARVRERVAAALPDYMT 937 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PA YVVLDEIPITAHGKIDRAALP P+I + T++R PQT TE+ LAQLF ELLG RVG Sbjct 938 PAGYVVLDEIPITAHGKIDRAALPLPEITTATDYREPQTETEQHLAQLFSELLGVARVGV 997 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSA---RP 1017 DDSFF+LGGHSLLATKLV+AVR+ GVD+ +REIFE TV LA +D L + + RP Sbjct 998 DDSFFELGGHSLLATKLVSAVRSRCGVDMEIREIFELGTVARLAERVDELAAGGSAPLRP 1057 Query 1018 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1077 RL V HDGP +S++Q+R WF YR +GP VNN+PFAA GPCD +A A+ DVV R Sbjct 1058 RLLAVPHDGPAPMSAAQLRQWFQYRIEGPGPVNNVPFAARFAGPCDVDALIEAVRDVVNR 1117 Query 1078 HEILRTVYREIGGVPHQIIQPP-AEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIR 1136 HE LRT + EI GVP+Q++ P PVR +G D AWL L++ER VFDLE WPIR Sbjct 1118 HESLRTTFCEIDGVPYQLVNAPDPGFPVRRDSGPDDAWLVGALDDERRRVFDLENQWPIR 1177 Query 1137 AALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSV 1196 A+LS P + LS+VVHHIA DHWS GVLFT+LLTAYRAR G+ P+WAPLPVQYADY+ Sbjct 1178 VAVLSIPGEHALSVVVHHIAADHWSGGVLFTELLTAYRARRAGEAPTWAPLPVQYADYAA 1237 Query 1197 WQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRD 1256 WQSALL D +GIV QR YW +QL GL+ ETGL+PD RP++ SGA DAVEF L AAIR+ Sbjct 1238 WQSALLADDSGIVAAQRRYWTQQLEGLSAETGLQPDLVRPSVPSGAADAVEFTLDAAIRE 1297 Query 1257 KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVV 1316 KL +SR++G TEFMLLQAAVAV L+KAG G D+P+G PVAGR+E+ LDQLIGFFINI+V Sbjct 1298 KLVTLSREVGATEFMLLQAAVAVTLYKAGEGPDIPLGTPVAGRTESELDQLIGFFINILV 1357 Query 1317 LRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE 1376 LRNDLR NP+LR+V R+R+MALAAYAHQDLPFDQVV+AV+P RSLSRNPLF +VVHVRE Sbjct 1358 LRNDLRDNPSLRDVGFRSREMALAAYAHQDLPFDQVVDAVSPVRSLSRNPLFGVVVHVRE 1417 Query 1377 QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQ 1436 ++PQD VI TG DG+TT LEPTFD A ADLSVNFFA G+ YRGHVIYRTELY RATA+ Sbjct 1418 ELPQDRVIATGSDGETTFTALEPTFDMAHADLSVNFFAGGNGYRGHVIYRTELYTRATAE 1477 Query 1437 RFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPV 1496 RFA WL V+ AFAD P++ + +V V A+ R G G A LLD A PVPV Sbjct 1478 RFAGWLSAVITAFADDPERHVDDV--VIAEPVR-------PGDG-AEAVLLDGAGHPVPV 1527 Query 1497 GVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLA 1556 GVV DV+Y G P R G+R W DG+L+ + Sbjct 1528 GVVADVHYAGAPD-----------------------------RRGDRARWTEDGRLQYVE 1558 Query 1557 EIE 1559 ++ Sbjct 1559 RVD 1561 Score = 117 bits (292), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 64/113 (57%), Positives = 82/113 (73%), Gaps = 6/113 (5%) Query 1570 PAEPADTETERALAAILADVL-EVGE---VGRYDDFFNLGGDSILATQVAARARDGGIPL 1625 P+EPA T+TE+AL +LADVL EV + +GR+DDFF LGGDSILA Q+AARA+ G+ L Sbjct 1644 PSEPARTDTEKALVGMLADVLVEVHDGTGIGRFDDFFELGGDSILAVQLAARAKQAGLRL 1703 Query 1626 TARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASW 1678 +ARMVFEHPV+ +LA A+D E D H PMS SGL+P+EL+ + SW Sbjct 1704 SARMVFEHPVVHDLAVALDTAKTPEVA--DVRHDPMSASGLTPEELAMVATSW 1754 Score = 111 bits (278), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 108/346 (32%), Positives = 155/346 (45%), Gaps = 41/346 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 + Q R WF + D + N+ + + G D A+T V RH +LRT + + Sbjct 43 FTDGQKRMWFVHSVDPSGVLLNVCLSYRISGEVDLARLHDAVTAVARRHPVLRTTFAADE 102 Query 1089 GGVPHQIIQ----PPAEVPVRCAAGSDAAWLRAELNNER--GYVFDLETDWPIRAALLST 1142 G P + + P V A LR E+ +R G FDL T+ P+R + T Sbjct 103 AGEPQRTVHDDLLPGWTVQDISELSEHARRLRLEVLAQREFGTPFDLATESPLRITVART 162 Query 1143 -PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPL---PVQYADYSVWQ 1198 P + ++ LVVHHIA D V F DL AY G P+ AP+ P D W+ Sbjct 163 APAEYIMLLVVHHIAWDDGCWRVFFADLTRAYTGAELG--PTPAPVVEPPTSDEDLRFWR 220 Query 1199 SALLD--DGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRD 1256 SA+ D + + GP G A T R R + + D VE Sbjct 221 SAMTDLPEPLELPGPH---------GSAVPTTWR---CRRVTATLSADTVE--------- 259 Query 1257 KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVV 1316 ++ +R+ G T +M++ AA +LH+ DV I +PV R + D +IG+ N V Sbjct 260 RVRVAAREAGATPYMVMLAAFGALLHRYTHADDVLIASPVLLRGPDSED-VIGYHGNSAV 318 Query 1317 LRNDLRGNP--TLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 +R LR P T E+L RTR AL A+AHQ + D+VV +N R Sbjct 319 MR--LRPQPMQTFTELLSRTRDFALDAFAHQQVNLDRVVRELNLDR 362 Score = 68.2 bits (165), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 83/288 (29%), Positives = 119/288 (42%), Gaps = 64/288 (22%) Query 742 RPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMY 801 RP LLD + PVP GV+ +++ G Sbjct 1508 RPGDGAEAVLLDGAGHPVPVGVVADVHYAGAP---------------------------D 1540 Query 802 RSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLG 861 R GD AR DG +++V R D ++ + AA + +G VV Sbjct 1541 RRGDRARWTEDGRLQYVERVDHDLEAALAAVPGVAAAAVRTWE--IGHRTAVV------- 1591 Query 862 KSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRA 921 GYV PA D PA + +RA VA PE P + VLD +P T R Sbjct 1592 ----GYVVPAEPVDDPASFA---ETVRAAVA---PESA-PTSITVLDALPAT------RR 1634 Query 922 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDR----VGADDSFFDLGGHSLLATKL 977 ALP P++ +E +T TE+ L + ++L +G D FF+LGG S+LA +L Sbjct 1635 ALPAPRVGGPSE--PARTDTEKALVGMLADVLVEVHDGTGIGRFDDFFELGGDSILAVQL 1692 Query 978 VAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHD 1025 A + A G+ + R +FE V LA +DT + P + V HD Sbjct 1693 AARAKQA-GLRLSARMVFEHPVVHDLAVALDTAKT----PEVADVRHD 1735 Score = 53.1 bits (126), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 43/116 (38%), Positives = 59/116 (51%), Gaps = 12/116 (10%) Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LP A EP TETE+ LA + +++L V VG D FF LGG S+LAT++ + R Sbjct 962 LPEITTATDYREP-QTETEQHLAQLFSELLGVARVGVDDSFFELGGHSLLATKLVSAVRS 1020 Query 1621 -GGIPLTARMVFEHPVLCELAAAVDA---------KPHVEAEPDDKHHAPMSTSGL 1666 G+ + R +FE + LA VD +P + A P D APMS + L Sbjct 1021 RCGVDMEIREIFELGTVARLAERVDELAAGGSAPLRPRLLAVPHDG-PAPMSAAQL 1075 >gi|289758503|ref|ZP_06517881.1| peptide synthetase mbtE [Mycobacterium tuberculosis T85] gi|289714067|gb|EFD78079.1| peptide synthetase mbtE [Mycobacterium tuberculosis T85] Length=1072 Score = 2020 bits (5233), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1017/1017 (100%), Positives = 1017/1017 (100%), Gaps = 0/1017 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 50 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 109 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 110 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 169 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 170 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 229 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 230 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 289 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 290 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 349 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 350 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 409 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 410 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 469 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 470 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 529 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 530 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 589 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 590 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 649 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 650 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 709 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 710 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 769 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 770 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 829 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 830 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 889 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML Sbjct 890 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 949 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA Sbjct 950 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 1009 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 1017 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP Sbjct 1010 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 1066 Score = 114 bits (286), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 106/350 (31%), Positives = 151/350 (44%), Gaps = 41/350 (11%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 RLS Q R WF D A+ NI + + G D A+ V RH ILRT Y + Sbjct 42 RLSDGQARMWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PV 100 Query 1089 GGVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAA 1138 G + QP +R A LR E+ +R + F+L D P+R Sbjct 101 GD--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRIT 158 Query 1139 LLSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQ 1190 ++ T ++ VL LV HHIA D S V FTDL AY G RPS A P Sbjct 159 VVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT 218 Query 1191 YADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRL 1250 AD + W++ + D + + G T R RL Sbjct 219 EADLNYWRAIMADPPEPLE-------LPGPAGTCVPTSWR------------AARATLRL 259 Query 1251 GAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGF 1310 A ++A ++++ G T +M+L AA ++H+ D + APV R A + IG+ Sbjct 260 PADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGY 318 Query 1311 FINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 F N V +R + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 319 FGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 368 Score = 70.1 bits (170), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 35/72 (49%), Positives = 47/72 (66%), Gaps = 2/72 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 ++LLDD+L+PVP GV+G++Y GG R TA RFVADPF PGSR+YR+G+ Sbjct 798 MHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDL 855 Query 1544 GVWKADGQLELL 1555 ADG +E + Sbjct 856 ARRNADGDIEFV 867 Score = 52.0 bits (123), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/96 (37%), Positives = 49/96 (52%), Gaps = 8/96 (8%) Query 1566 AAPVPAEPADTE-------TERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 1618 A P P +DTE TER LA + ++L VG D FF+LGG S+LAT++ A Sbjct 971 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAV 1030 Query 1619 RDG-GIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 1653 R+ G+ + R +FE + LA +D A P Sbjct 1031 RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 1066 >gi|240169032|ref|ZP_04747691.1| linear gramicidin synthetase subunit D [Mycobacterium kansasii ATCC 12478] Length=2173 Score = 1982 bits (5136), Expect = 0.0, Method: Compositional matrix adjust. Identities = 974/1488 (66%), Positives = 1183/1488 (80%), Gaps = 17/1488 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WFVQ DPS +LLN+C SYR+TG +D+ RL A++AVA RH +LRTTY DDG +P Sbjct 45 LWFVQSIDPSSSLLNVCASYRLTGTVDVGRLHRALDAVAVRHPVLRTTYHADDDGDPRPV 104 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VH DLRPGW Q+DL LS++A++LRLEVLAQR+F PF+L+ D+PLR+T VR + DE +L Sbjct 105 VHDDLRPGWAQHDLCGLSEQARQLRLEVLAQRQFRRPFDLAADSPLRVTAVRLSNDELML 164 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDD SW FFTDLT+AYS G D P+A +G T + DL YWR++M Sbjct 165 LITAHHIAWDDASWGPFFTDLTRAYSDT-AGLDGATPPVPAATAG--TLDEDLAYWRSLM 221 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPG G+ VP++WRA R + +L ADT RV +A TPY+V+LAAF AL Sbjct 222 ADLPEPLELPGANGSAVPSTWRAQRVSAQLSADTLGRVTALAGKCEATPYVVMLAAFAAL 281 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 +HRYTH+ DFL+AAPV +R AG E+AIGY+GNTV +R +PQ +FR+LL TRD+ +GA Sbjct 282 IHRYTHATDFLIAAPVTDRNAGAENAIGYYGNTVVVRAQPQPRQTFRDLLAHTRDVTTGA 341 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQR+NLD +VRE NPDRRHGA+RMTRVSFG RE DGGGF PPG++C R DL+ +QL Sbjct 342 FAHQRVNLDWLVRESNPDRRHGADRMTRVSFGLRESDGGGFCPPGVQCRRGDLQGQFSQL 401 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PL F VE G LVEAE+LVE+L+P LA Q+L H+ +LLD+ALA PD L+ L+L Sbjct 402 PLSFTVELSGTGALVEAEYLVEVLDPPLATQLLEHYAILLDSALADPDTELNRLSLFGAA 461 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 +A LR+V+ G++F T T+ LV E+ +PDA AVVYE + +TY +LNE +NRL HW Sbjct 462 EAEWLRKVATGQQFSTTPTTMPALVAERAASSPDAVAVVYEDRQYTYRELNEEANRLAHW 521 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LI+QG+G+EDRVAV+LDKSP+L++TALGV+K+GAVY+PVDP+YP+DRL +IL D +AKLV Sbjct 522 LIDQGVGTEDRVAVVLDKSPELVITALGVLKAGAVYLPVDPTYPEDRLSYILDDAEAKLV 581 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LR PV +LAGY DP + +RPLRP NTAYLIYTSG+TGLPKGV VPH PV EYFVWF Sbjct 582 LREPVTDLAGYSPADPAPDELVRPLRPANTAYLIYTSGSTGLPKGVPVPHAPVTEYFVWF 641 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 EY VD+TDRLLQVASP FDVSIAEIFG L CG R+VIPRP GL DIGYLT LL EGI Sbjct 642 GDEYQVDETDRLLQVASPGFDVSIAEIFGLLICGGRLVIPRPDGLRDIGYLTDLLYREGI 701 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 T+MHFVPSLLGLFLSLPGV+QWRTL+RVPIGGEPLPGEVADKFHATFDALL+NFYGPTET Sbjct 702 TSMHFVPSLLGLFLSLPGVNQWRTLRRVPIGGEPLPGEVADKFHATFDALLYNFYGPTET 761 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINA+ ++V G QGTRIVPIGRPKINT ++LLDD+LQPVP GVIGEIYIGGTH+A+GYHR Sbjct 762 VINATSYQVEGTQGTRIVPIGRPKINTQVYLLDDALQPVPVGVIGEIYIGGTHMAHGYHR 821 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 R LTAERFVADPF PG R+YRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG++AAA Sbjct 822 RPALTAERFVADPFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGEIAAA 881 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 I+VDP+VGQAVV+ DLP LGKSLVGYVTP+ GG VD+DRIRARVAAALP+YM Sbjct 882 ISVDPSVGQAVVIAIDLPGLGKSLVGYVTPSDGGTE----TVDVDRIRARVAAALPDYMT 937 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPIT HGKIDR ALP+P+IAS E+R P TA+ER +A LF +LLG DRVG Sbjct 938 PAAYVVLDEIPITTHGKIDRDALPQPEIASAAEYREPTTASERIVAGLFTQLLGHDRVGV 997 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSA---RP 1017 DDSFFDLGGHSL+ATKLVAA+R+ G ++G+R++FE TV LA +D + S + RP Sbjct 998 DDSFFDLGGHSLVATKLVAAIRSECGAELGIRDVFELVTVGRLAERVDQVQSGAVTFKRP 1057 Query 1018 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1077 +L + H+GP+ LS++Q+R+WF Y+ +GP+ VNNIPFAA L GPCD +A AA++DVV R Sbjct 1058 KLVKTPHEGPLPLSAAQLRTWFAYQIEGPSEVNNIPFAARLSGPCDVDALVAAVSDVVRR 1117 Query 1078 HEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRA 1137 HEILRT Y EI GVP+Q++QP AE+PVR AAG A WLR +L++ER Y F L+ +WPIRA Sbjct 1118 HEILRTTYTEIDGVPYQVVQPAAELPVRQAAGEGAGWLRQQLDSERHYSFQLDREWPIRA 1177 Query 1138 ALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVW 1197 A+L T ++ V+SLVVHHIA DHWS GVLF DLLTAYRAR + Q+PSWAPLP+QYADY+ W Sbjct 1178 AVLHTGDEHVVSLVVHHIAIDHWSGGVLFADLLTAYRARHSRQQPSWAPLPLQYADYAAW 1237 Query 1198 QSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAI 1254 Q LL DD + I QRDYW+RQL G+ +TGLRPD PRP + SGAGD+VEF +GA Sbjct 1238 QGELLSEQDDQSSIARAQRDYWVRQLEGIPEDTGLRPDLPRPGVPSGAGDSVEFSIGAQA 1297 Query 1255 RDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINI 1314 R KL + R+LGVTEFMLLQ+AVAVVLHKAGGGVD+P+G P+A R+E LDQLIGFFINI Sbjct 1298 RGKLTELCRELGVTEFMLLQSAVAVVLHKAGGGVDIPLGTPIAARTEPELDQLIGFFINI 1357 Query 1315 VVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1374 +VLRN+L GNP+LREVL R R+ ALAAYAHQDLPFD+VV+AV+P R+LSRNPLF VVHV Sbjct 1358 LVLRNNLDGNPSLREVLTRARETALAAYAHQDLPFDRVVDAVSPVRTLSRNPLFQTVVHV 1417 Query 1375 REQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGD----EYRGHVIYRTELY 1430 R+ +P + VIDT G+T LEPTFD A ADLSVNFFA D Y+G+++YRTELY Sbjct 1418 RDHLPGERVIDTSAAGNTVFTALEPTFDIAHADLSVNFFATSDAEEAAYQGNILYRTELY 1477 Query 1431 ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAG 1478 R+T +R WL++V++AFA DQ LR+V+++ A+ R+ IL R + G Sbjct 1478 HRSTIERLVGWLMQVIDAFAGDVDQRLRDVQLLDAEQRQHILARWSRG 1525 Score = 387 bits (995), Expect = 8e-105, Method: Compositional matrix adjust. Identities = 348/1131 (31%), Positives = 506/1131 (45%), Gaps = 128/1131 (11%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDD---GVAQ 58 WF + + NI + R++G D+ L AV+ V RRH ILRTTY D V Q Sbjct 1078 WFAYQIEGPSEVNNIPFAARLSGPCDVDALVAAVSDVVRRHEILRTTYTEIDGVPYQVVQ 1137 Query 59 PTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 P +R + A LR ++ ++R + F+L R+ P+R V+ T DEH Sbjct 1138 PAAELPVRQA--------AGEGAGWLRQQLDSERHYS--FQLDREWPIRAAVLHTG-DEH 1186 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAY----------------SRADLGADLGPEHRPSA 162 V+ LV HHIA D S V F DL AY AD A G E Sbjct 1187 VVSLVVHHIAIDHWSGGVLFADLLTAYRARHSRQQPSWAPLPLQYADYAAWQG-ELLSEQ 1245 Query 163 ASGPDTTEADLNYWRAIMADPPEPL----ELPGPAGTCVPTSWRAARATLRLPADTAARV 218 A +YW + PE +LP P VP S + A ++ Sbjct 1246 DDQSSIARAQRDYWVRQLEGIPEDTGLRPDLPRPG---VP-SGAGDSVEFSIGAQARGKL 1301 Query 219 ATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVAMR 277 + + G T +M+L +A ++H+ D + P+ R D IG+F N + +R Sbjct 1302 TELCRELGVTEFMLLQSAVAVVLHKAGGGVDIPLGTPIAARTEPELDQLIGFFINILVLR 1361 Query 278 LRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPD 337 S RE+LT R+ A A+AHQ + DRVV ++P R + + R+ Sbjct 1362 NNLDGNPSLREVLTRARETALAAYAHQDLPFDRVVDAVSPVRTLSRNPLFQTVVHVRD-- 1419 Query 338 GGGFNPPGIECERYDLRSNIT-------------QLPLGFMVEFDRAGVLVEAEHL--VE 382 + PG N L + F D + L E Sbjct 1420 ----HLPGERVIDTSAAGNTVFTALEPTFDIAHADLSVNFFATSDAEEAAYQGNILYRTE 1475 Query 383 ILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMD-ERDAARLREVSRGERFDTPVK-- 439 + + ++++ ++D D L + L+D E+ L SRG + P + Sbjct 1476 LYHRSTIERLVGWLMQVIDAFAGDVDQRLRDVQLLDAEQRQHILARWSRGP--EPPAERA 1533 Query 440 -TLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDK 498 T+ +L+ + A+ + Y L+ S+ H L+E+G+G V + + Sbjct 1534 CTIAELLEPSRRWGTNRIALRCADEQIDYPALHRRSDNFAHLLVERGVGPGSLVGLSTRR 1593 Query 499 SPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP--------VRELAG 550 D++V +G++K+ A + P+DP YP R +L D ++V+ T E+ Sbjct 1594 GIDMVVALVGIMKASAGFFPLDPGYPAARKQLMLDDVAPQVVVVTSEALETMPESPEVTF 1653 Query 551 YRSDDPT---------DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFK 601 DDP AD + PD+ YL++TSG+TG PKGV HR + W Sbjct 1654 ISLDDPAVQEALDREPSADPLPAAHPDDPMYLVFTSGSTGTPKGVLGTHRAMTTRLNWQL 1713 Query 602 GEYDV---DDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDE 658 Y V D D L AS +F E G LA G+ ++ D L +L+R Sbjct 1714 WNYPVAGNDTEDIRLAQASWNFLEGCMETLGGLAAGSTTILADDTEHRDPEALASLIRRH 1773 Query 659 GITAMHFVPSLLGLFLSLPGVSQW----RTLQRVPIGGEPLPGEVADKFHATFDA----- 709 + + VPSL+ V W R+L R+ G EPL + ++ A + + Sbjct 1774 SVAQVTAVPSLVSTI-----VDTWPEALRSLYRLVCGAEPLTASLQERLLAHYGSDGSGS 1828 Query 710 ---LLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 LL+NF G TET S V GP + +G P + ++LLDD L PVP GV+GE Sbjct 1829 GPQLLNNF-GATET----SGALVRGPMTPPVPLLGTPMPDAQVYLLDDGLNPVPPGVVGE 1883 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDLARRNADGDIEFVGRADEQ 824 +Y G + GY +R GLTA RFVA+P+ PG+R YRSGD AR DG +EFVGR D Q Sbjct 1884 LYYAGGQLVRGYWKRPGLTAARFVANPYAAEPGARFYRSGDRARWTQDGRLEFVGRTDHQ 1943 Query 825 VKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDL 884 VK+RGFR+ELG+V AA+ V A D+ +L GYV P G Sbjct 1944 VKVRGFRVELGEVEAALKAADGVAVAAARTWDVDG-SITLAGYVVPHHPAPGEEAKSAFA 2002 Query 885 DRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERR 944 +RA VAA LP YM+P++ VLDE+P T GK++R LP P +++ P T ER Sbjct 2003 SAVRAEVAAVLPGYMMPSSITVLDEMPKTESGKLNRPGLPRPSVSTTGHREPPSTDIERA 2062 Query 945 LAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALA 1004 LA++F +LL + +G D FF LGG S+L+ +L A R A G+ V R +FE TV LA Sbjct 2063 LAEIFVDLLPINEIGRFDDFFTLGGDSILSVQLAARARAA-GLPVSPRLVFENPTVQQLA 2121 Query 1005 GHIDT--------LDSDSARPRLTRVDHDGPVR---LSSSQM----RSWFN 1040 +++ LDS A H P+ LS+ Q+ +SW N Sbjct 2122 AAVESGVESTGAVLDSGGADGAADADTHHEPMSTSGLSAEQLAAVTQSWSN 2172 Score = 109 bits (273), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 102/365 (28%), Positives = 156/365 (43%), Gaps = 44/365 (12%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-EI 1088 LS Q R WF D +++ N+ + L G D A+ V RH +LRT Y + Sbjct 38 LSDGQRRLWFVQSIDPSSSLLNVCASYRLTGTVDVGRLHRALDAVAVRHPVLRTTYHADD 97 Query 1089 GGVP----HQIIQPPAEVPVRCAAGSDAAWLRAELNNERGY--VFDLETDWPIR-AALLS 1141 G P H ++P C A LR E+ +R + FDL D P+R A+ Sbjct 98 DGDPRPVVHDDLRPGWAQHDLCGLSEQARQLRLEVLAQRQFRRPFDLAADSPLRVTAVRL 157 Query 1142 TPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSAL 1201 + ++ +L + HHIA D S G FTDL AY + + G + P+P Sbjct 158 SNDELMLLITAHHIAWDDASWGPFFTDLTRAY-SDTAGLDGATPPVPAAT---------- 206 Query 1202 LDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA----------VEFRLG 1251 AG + YW L D P P L GA + V +L Sbjct 207 ----AGTLDEDLAYW----------RSLMADLPEPLELPGANGSAVPSTWRAQRVSAQLS 252 Query 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 A ++ A++ T ++++ AA A ++H+ D I APV R+ A + IG++ Sbjct 253 ADTLGRVTALAGKCEATPYVVMLAAFAALIHRYTHATDFLIAAPVTDRN-AGAENAIGYY 311 Query 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 N VV+R + T R++L TR + A+AHQ + D +V NP R + + + Sbjct 312 GNTVVVRAQPQPRQTFRDLLAHTRDVTTGAFAHQRVNLDWLVRESNPDRRHGADRMTRVS 371 Query 1372 VHVRE 1376 +RE Sbjct 372 FGLRE 376 Score = 105 bits (261), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 61/120 (51%), Positives = 80/120 (67%), Gaps = 11/120 (9%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EP T+ ERALA I D+L + E+GR+DDFF LGGDSIL+ Q+AARAR G+P++ R+VF Sbjct 2053 EPPSTDIERALAEIFVDLLPINEIGRFDDFFTLGGDSILSVQLAARARAAGLPVSPRLVF 2112 Query 1632 EHPVLCELAAAV-----------DAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQ 1680 E+P + +LAAAV D+ A D HH PMSTSGLS ++L+A+T SW Sbjct 2113 ENPTVQQLAAAVESGVESTGAVLDSGGADGAADADTHHEPMSTSGLSAEQLAAVTQSWSN 2172 Score = 93.6 bits (231), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 43/78 (56%), Positives = 55/78 (71%), Gaps = 0/78 (0%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 A+VYLLDD L PVP GVVG++YY GG V RP TA RFVA+P+AA+PG+R YR+G Sbjct 1864 AQVYLLDDGLNPVPPGVVGELYYAGGQLVRGYWKRPGLTAARFVANPYAAEPGARFYRSG 1923 Query 1542 ERGVWKADGQLELLAEIE 1559 +R W DG+LE + + Sbjct 1924 DRARWTQDGRLEFVGRTD 1941 Score = 78.2 bits (191), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 40/73 (55%), Positives = 50/73 (69%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +VYLLDDAL+PVPVGV+G++Y GG RP+ TA RFVADPF PG RLYR+G+ Sbjct 789 QVYLLDDALQPVPVGVIGEIYIGGTHMAHGYHRRPALTAERFVADPFT--PGGRLYRSGD 846 Query 1543 RGVWKADGQLELL 1555 ADG +E + Sbjct 847 LARRNADGDIEFV 859 Score = 42.7 bits (99), Expect = 0.68, Method: Compositional matrix adjust. Identities = 28/70 (40%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T +ER +A + +L VG D FF+LGG S++AT++ A R + G L R VFE Sbjct 976 TASERIVAGLFTQLLGHDRVGVDDSFFDLGGHSLVATKLVAAIRSECGAELGIRDVFELV 1035 Query 1635 VLCELAAAVD 1644 + LA VD Sbjct 1036 TVGRLAERVD 1045 >gi|296170584|ref|ZP_06852167.1| linear gramicidin synthetase subunit D [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894748|gb|EFG74474.1| linear gramicidin synthetase subunit D [Mycobacterium parascrofulaceum ATCC BAA-614] Length=2179 Score = 1942 bits (5031), Expect = 0.0, Method: Compositional matrix adjust. Identities = 988/1493 (67%), Positives = 1157/1493 (78%), Gaps = 33/1493 (2%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLN+CVSYR+TG +D+ RLR AV+AVA RHR+L TTY G DG P Sbjct 52 MWFVQAVDPGSALLNVCVSYRVTGGVDVERLRRAVDAVAARHRVLHTTYHTGADGDPYPV 111 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V LRP W ++DL+ L+ +A+RLRL+VLAQR+F PF+L++D+PLR+TV R +ADE +L Sbjct 112 VREQLRPEWAEHDLSGLTDQARRLRLDVLAQRDFRRPFDLAKDSPLRVTVARLSADELML 171 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGP--DTTE--ADLNYW 176 L+ AHHIAWDD SW FF DLT+AY+ D G P+AA+ P D T+ AD +YW Sbjct 172 LITAHHIAWDDASWAPFFADLTRAYTDPD-----GFRGEPTAAAPPPDDVTDPAADFDYW 226 Query 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 R +MA+ PEPLELPGP G+ VP +WRA R T RL ADT R A +A+ TG TPYMVL+AA Sbjct 227 RPLMANLPEPLELPGPHGSVVPGTWRAQRTTRRLSADTVDRAAALARETGATPYMVLMAA 286 Query 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 F ALVHRYT S DFL+AAPVLNRG GTE AIGY+GNTV +RLRP +FRELL TRD Sbjct 287 FAALVHRYTQSTDFLIAAPVLNRGVGTESAIGYYGNTVVVRLRPGPRQTFRELLAQTRDS 346 Query 297 ASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSN 356 A GAFAH R +LD +VRE NPDRRHGA+RMTRVSFG REPDG GF PPG+ CER +LR + Sbjct 347 AVGAFAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGAGFCPPGVRCERAELRGH 406 Query 357 ITQLPLGFMVEFDRA-GVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 QLPL FM+E DRA G LVEAE+LVE+L+ LA Q+LRH+ VLLD+AL+ PD LS A Sbjct 407 FNQLPLSFMIELDRANGGLVEAEYLVEVLDQQLADQLLRHYTVLLDDALSNPDAALSACA 466 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LMD DA LR S G FDTP TL LV + R+PDA AVVYE + +TY ++ E SN Sbjct 467 LMDTDDAEWLRRASAGAPFDTPAATLPALVTRRAARSPDAVAVVYERREYTYREIVEESN 526 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 RL HWLIEQGIG+EDRVAVLLDKSP+L++TALGV+K+GAVY+PVDP+YP DRL FIL D Sbjct 527 RLAHWLIEQGIGTEDRVAVLLDKSPELVITALGVLKAGAVYLPVDPTYPADRLAFILGDA 586 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV LA Y + PT+ +RPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 587 DAKLVLREPVTGLARYPAAAPTEL--VRPLSPQNTAYLIYTSGSTGLPKGVPVPHAPIAE 644 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY VD+TDRLLQVASPSFDVS+ EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 645 YFVWFGDEYHVDETDRLLQVASPSFDVSMGEIFGTLIMGARLVIPRPDGLRDIGYLTELL 704 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPGV QWRTL+RVPIGGE LPGE+ADKFHATFDALL+NFY Sbjct 705 SREGITSMHFVPSLLGLFLSLPGVGQWRTLRRVPIGGEALPGEIADKFHATFDALLYNFY 764 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTR+VPIGRPKINT +HLLD++L+PVP GVIGEIYIGGTHVA Sbjct 765 GPTETVVNCTSYPVEGTQGTRVVPIGRPKINTQVHLLDNALRPVPAGVIGEIYIGGTHVA 824 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR GLTAERFVADPF PG R+YRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG Sbjct 825 HGYHRRPGLTAERFVADPFTPGGRLYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 884 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLPRLGKSLVGYVTPA GG V+++RIRARVAAAL Sbjct 885 EIAAAISVDPSVGQAVVLAMDLPRLGKSLVGYVTPAEGGPE----TVEVERIRARVAAAL 940 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYV LDEIPITAHGKIDR ALP+PQIA+ +R P T TERR+A LF LLG Sbjct 941 PDYMTPAAYVPLDEIPITAHGKIDRTALPQPQIAAAAAYRDPSTPTERRVAALFSSLLGH 1000 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDS- 1014 DRVG DDSFFDLGGHSL+ATKLV A+R+ G ++G+R++FEF TV LAG +D L S Sbjct 1001 DRVGVDDSFFDLGGHSLVATKLVTAIRSECGAELGIRDVFEFPTVGLLAGRVDQLSSGEP 1060 Query 1015 --ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 RP+L HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D +A AA+ Sbjct 1061 GRTRPKLIATAHDEPMPLSASQLRSWFAYRVDGPSWVNNIPFAAKLSGPWDVDALIAAVG 1120 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETD 1132 DVV RHEILRT Y E+ GVP+Q++ P EV VR G D AWLR EL+ ER + F+L+ + Sbjct 1121 DVVGRHEILRTSYVELDGVPYQVVGPVGEVAVRRGTGPDEAWLRRELDAERRHCFELDRE 1180 Query 1133 WPIRAALLST---PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 P+R A+L T P + VLSLVVHHIA DHWSAGVLF D++TAYRAR G+ P+WAPL V Sbjct 1181 LPLRVAVLHTADNPAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRAGEAPAWAPLRV 1240 Query 1190 QYADYSVWQSALLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 QYADY+ WQ A L D G + QR+YW RQL GL +TG RPDFPR + SG G++ Sbjct 1241 QYADYAAWQGAFLGDANGQESAVAAEQREYWNRQLAGLPEDTGPRPDFPRQPVPSGEGES 1300 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 V FR+ AA R KLA +SR+LG+TEFMLLQ AVAVVLHKAGGG D+P+G PVAGR+EA LD Sbjct 1301 VGFRIDAATRVKLAELSRELGITEFMLLQTAVAVVLHKAGGGADIPLGTPVAGRTEAELD 1360 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 QLIGFF+NI+VLRNDL GNPTLRE+L R R+ ALAAYAHQDLPFD+VV++V+P RSLSRN Sbjct 1361 QLIGFFVNILVLRNDLTGNPTLRELLTRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1420 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDG---DTTLRVLEPTFDAAQADLSVNFFAC----GDE 1418 PLF +VVHVRE + VI+ P G DT L+P FD A ADLSVNFF G Sbjct 1421 PLFQVVVHVREHLTATRVIEQAPAGGGADTVCTSLDPVFDMAHADLSVNFFGTDGSGGVG 1480 Query 1419 YRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRI 1471 Y ++I+RTELY RAT +R A WL+RVV FAD DQ LR+V++ A RRR+ Sbjct 1481 YDCNLIFRTELYARATIERLAGWLIRVVTEFADNVDQTLRDVQLTDAAERRRM 1533 Score = 429 bits (1102), Expect = 3e-117, Method: Compositional matrix adjust. Identities = 367/1085 (34%), Positives = 507/1085 (47%), Gaps = 101/1085 (9%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGV----A 57 WF D + NI + +++G D+ L AV V RH ILRT+Y V DGV Sbjct 1086 WFAYRVDGPSWVNNIPFAAKLSGPWDVDALIAAVGDVVGRHEILRTSY-VELDGVPYQVV 1144 Query 58 QPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAAD- 116 P +R G LR E+ A+R C FEL R+ PLR+ V+ TA + Sbjct 1145 GPVGEVAVRRG--------TGPDEAWLRRELDAERRHC--FELDRELPLRVAVLHTADNP 1194 Query 117 -EHVLLLVAHHIAWDDGSWRVFFTDLTQAY----------------SRADL----GADLG 155 EHVL LV HHIA D S V F D+ AY AD GA LG Sbjct 1195 AEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRAGEAPAWAPLRVQYADYAAWQGAFLG 1254 Query 156 PEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPT-SWRAARATLRLPADT 214 + +A + E YW +A PE P P P S R+ A T Sbjct 1255 DANGQESAVAAEQRE----YWNRQLAGLPEDTG-PRPDFPRQPVPSGEGESVGFRIDAAT 1309 Query 215 AARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNT 273 ++A +++ G T +M+L A ++H+ D + PV R D IG+F N Sbjct 1310 RVKLAELSRELGITEFMLLQTAVAVVLHKAGGGADIPLGTPVAGRTEAELDQLIGFFVNI 1369 Query 274 VAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRR-----------HG 322 + +R + RELLT R+ A A+AHQ + DRVV ++P R H Sbjct 1370 LVLRNDLTGNPTLRELLTRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHV 1429 Query 323 AERMTRVSFGFREPDGGGFNP------PGIECERYDLRSNITQLPLGFMVEFDRAGVLVE 376 E +T + P GGG + P + DL N V +D ++ Sbjct 1430 REHLTATRVIEQAPAGGGADTVCTSLDPVFDMAHADLSVNFFGTDGSGGVGYD-CNLIFR 1488 Query 377 AEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGER--F 434 E LA ++R DN D TL + L D + R+ + SRGER Sbjct 1489 TELYARATIERLAGWLIRVVTEFADNV----DQTLRDVQLTDAAERRRMEQWSRGERPPR 1544 Query 435 DTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAV 494 D P +T+ +L+ + PD AV G+ Y L+ S+ L L +G+G V + Sbjct 1545 DRP-RTIPELLRPSRSWGPDRIAVRCGGEQIDYPALHRHSDNLAALLAARGVGPGALVGL 1603 Query 495 LLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT-----PVRELA 549 +S DL+V + ++K+G Y P+DP YP+ R F+L D +VL T + E+A Sbjct 1604 STRRSIDLVVALVAIMKAGGGYFPIDPGYPRARKQFMLDDVRPTVVLATADAADSMPEVA 1663 Query 550 GYRS---DDP------TDADRIRPL----RPDNTAYLIYTSGTTGLPKGVAVPHRPVAEY 596 G DDP + RP PD+ YL++TSG+TG PKG HR +A Sbjct 1664 GVTVISLDDPDVRAGIENGAAARPELPLPHPDDPMYLVFTSGSTGTPKGALGTHRSMAAR 1723 Query 597 FVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLR 656 W Y D L AS +F E+ LA GA M++ D L L+ Sbjct 1724 LDWQLRHYPPRTDDVRLAQASITFLEGGMEMLAGLAAGATMILADDAEHRDPEALGDLMT 1783 Query 657 DEGITAMHFVPSLLGLFL-SLPGVSQWRTLQRVPIGGEPLPGEVADKF---HATFDALLH 712 G+ + VPSL+ + S P R L R+ GGEP+ + + A D L Sbjct 1784 RHGVAQVTAVPSLVSALVDSRPDAV--RALSRLVCGGEPVGARLLRRLVSVCAGADVELL 1841 Query 713 NFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGT 772 N G TET SR ++ P +G+P +LLDD L+PVP GV+GE+Y G Sbjct 1842 NNIGSTETSGAVSRGRLEPPNPL----VGKPVPGADAYLLDDGLRPVPVGVVGELYYAGD 1897 Query 773 HVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGF 830 +A GY +R LTA RFVA+P+ PGSR+YRSGDLAR DG +EFVGR+D QV++RGF Sbjct 1898 QLARGYWQRPALTATRFVANPYALQPGSRLYRSGDLARWTEDGRLEFVGRSDHQVQVRGF 1957 Query 831 RIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRAR 890 R+EL +V AA+A V A ++ G SL GYV P R+RA Sbjct 1958 RVELAEVEAALAGVDGVAAAAARTWEV-HGGTSLAGYVVPHRPIAEDTGKAAFASRVRAA 2016 Query 891 VAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFG 950 + A LP YM+P++ VLD +P T GK++R LP P +++ +T TER LA++F Sbjct 2017 IGATLPAYMMPSSLTVLDTLPKTESGKLNRPGLPPPAVSTRGSVEPSRTGTERALAKVFA 2076 Query 951 ELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTL 1010 ELL VG D FF LGG S+L+ +L + R A G+ V R IFE +TV LA +D L Sbjct 2077 ELLSTPAVGRFDDFFALGGDSILSVQLASRARAA-GLAVSPRMIFENSTVQQLAAAVDAL 2135 Query 1011 DSDSA 1015 ++A Sbjct 2136 GHNAA 2140 Score = 109 bits (273), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 59/111 (54%), Positives = 77/111 (70%), Gaps = 4/111 (3%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EP+ T TERALA + A++L VGR+DDFF LGGDSIL+ Q+A+RAR G+ ++ RM+F Sbjct 2061 EPSRTGTERALAKVFAELLSTPAVGRFDDFFALGGDSILSVQLASRARAAGLAVSPRMIF 2120 Query 1632 EHPVLCELAAAVDAKPHVEAE----PDDKHHAPMSTSGLSPDELSALTASW 1678 E+ + +LAAAVDA H AE P D PMS SGLS D+L+A+T W Sbjct 2121 ENSTVQQLAAAVDALGHNAAEGPEQPADARFEPMSASGLSADDLAAVTRLW 2171 Score = 104 bits (259), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 106/357 (30%), Positives = 155/357 (44%), Gaps = 51/357 (14%) Query 1026 GPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY 1085 GP R+S+ Q R WF D +A+ N+ + + G D A+ V ARH +L T Y Sbjct 42 GP-RMSAGQHRMWFVQAVDPGSALLNVCVSYRVTGGVDVERLRRAVDAVAARHRVLHTTY 100 Query 1086 RE-IGGVPHQIIQP---PAEVPVRCAAGSDAA-WLRAELNNERGY--VFDLETDWPIRAA 1138 G P+ +++ P + +D A LR ++ +R + FDL D P+R Sbjct 101 HTGADGDPYPVVREQLRPEWAEHDLSGLTDQARRLRLDVLAQRDFRRPFDLAKDSPLRVT 160 Query 1139 LLS-TPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARS--TGQRPSWAPLPVQYADYS 1195 + + ++ +L + HHIA D S F DL AY G+ + AP P D + Sbjct 161 VARLSADELMLLITAHHIAWDDASWAPFFADLTRAYTDPDGFRGEPTAAAPPPDDVTDPA 220 Query 1196 VWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV--------- 1246 DYW L + P P L G +V Sbjct 221 A---------------DFDYW----------RPLMANLPEPLELPGPHGSVVPGTWRAQR 255 Query 1247 -EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 RL A D+ AA++R+ G T +M+L AA A ++H+ D I APV R + Sbjct 256 TTRRLSADTVDRAAALARETGATPYMVLMAAFAALVHRYTQSTDFLIAAPVLNRG-VGTE 314 Query 1306 QLIGFFINIVVLRNDLRGNP--TLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 IG++ N VV+R LR P T RE+L +TR A+ A+AH D +V NP R Sbjct 315 SAIGYYGNTVVVR--LRPGPRQTFRELLAQTRDSAVGAFAHSRADLDWLVRESNPDR 369 Score = 89.7 bits (221), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 43/74 (59%), Positives = 53/74 (72%), Gaps = 0/74 (0%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 A YLLDD L+PVPVGVVG++YY G RP+ TATRFVA+P+A QPGSRLYR+G Sbjct 1872 ADAYLLDDGLRPVPVGVVGELYYAGDQLARGYWQRPALTATRFVANPYALQPGSRLYRSG 1931 Query 1542 ERGVWKADGQLELL 1555 + W DG+LE + Sbjct 1932 DLARWTEDGRLEFV 1945 Score = 72.4 bits (176), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 37/73 (51%), Positives = 48/73 (66%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V+LLD+AL+PVP GV+G++Y GG RP TA RFVADPF PG RLYR+G+ Sbjct 797 QVHLLDNALRPVPAGVIGEIYIGGTHVAHGYHRRPGLTAERFVADPFT--PGGRLYRSGD 854 Query 1543 RGVWKADGQLELL 1555 ADG +E + Sbjct 855 LARRNADGDIEFV 867 Score = 47.8 bits (112), Expect = 0.019, Method: Compositional matrix adjust. Identities = 37/99 (38%), Positives = 51/99 (52%), Gaps = 3/99 (3%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TER +AA+ + +L VG D FF+LGG S++AT++ R + G L R VFE P Sbjct 984 TPTERRVAALFSSLLGHDRVGVDDSFFDLGGHSLVATKLVTAIRSECGAELGIRDVFEFP 1043 Query 1635 VLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSA 1673 + LA VD EP ++T+ P LSA Sbjct 1044 TVGLLAGRVDQLS--SGEPGRTRPKLIATAHDEPMPLSA 1080 >gi|118462221|ref|YP_881232.1| linear gramicidin synthetase subunit D [Mycobacterium avium 104] gi|118163508|gb|ABK64405.1| linear gramicidin synthetase subunit D [Mycobacterium avium 104] Length=2190 Score = 1931 bits (5002), Expect = 0.0, Method: Compositional matrix adjust. Identities = 985/1506 (66%), Positives = 1165/1506 (78%), Gaps = 29/1506 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLNICVSYR+TG +D RL AV+AVA RH +L TTY D+G +P Sbjct 49 MWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHTTYDTTDEGDPRPV 108 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + ADLRP W ++DL+ L+++A+RLRL+VLAQR+F PF+LS+D+PLR+T R A DE +L Sbjct 109 LRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAARLADDELML 168 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDDGSW FF DLT+AY+ A D P +A DL+YWR +M Sbjct 169 LITAHHIAWDDGSWAPFFADLTRAYT-APGDFDATPVVPDLSADPTAIRREDLDYWRPLM 227 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPGP G+ VP++WRA RA LPA+ R A +A+ TG TPYMVL+AAF AL Sbjct 228 ADLPEPLELPGPNGSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAAL 287 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DFLVAAPVLNRGA TE+ IGY+GNTV +RLRPQS SFRELL TRD A GA Sbjct 288 VHRYTGSTDFLVAAPVLNRGAATENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGA 347 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAH R +LD +VRE NPDRRHGA+RMTRVSFG REPDG GF PPG+ CER DLR + QL Sbjct 348 FAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGAGFCPPGVRCERGDLRGHFNQL 407 Query 361 PLGFMVEFDR-----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 PL MVE +R G LVEAE+LVE+L+ L +QMLRH+ LLD+ L+ PD TLS A Sbjct 408 PLSLMVELNRTPDGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACA 467 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM + DA LR VS GE+F TP TL +LV+ + RTPDA AVVYEG+ +TY D+ E SN Sbjct 468 LMSDADAEWLRAVSTGEQFITPAATLSELVSRRAARTPDAVAVVYEGRTYTYRDIEEESN 527 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ HWLIE+G+G+EDRVAVLLDKSP+L++TALGV+K+G VY+PVDP+YPQDRL+FIL D Sbjct 528 RVAHWLIERGVGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDA 587 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV +LA Y + PT+ +RPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 588 DAKLVLREPVTDLADYPATAPTEL--LRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAE 645 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY +D+TDRLLQVASPSFDVSI EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 646 YFVWFGDEYRIDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELL 705 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPGVSQWRTL+RVPIGGE LPGE+ADKFHATFDA L+NFY Sbjct 706 AREGITSMHFVPSLLGLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFY 765 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTR+VPIGRPKINT ++LLD++LQPVP GVIGEIYI GTHVA Sbjct 766 GPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVA 825 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR LTAERFVADPF+ G RMYRSGDLARRNA+GDIEFVGRADEQVKIRGFRIELG Sbjct 826 HGYHRRPQLTAERFVADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELG 885 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLP+LGKSLVGYVTPA G VD++RIRARVAAAL Sbjct 886 EIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGAGTET---VDVERIRARVAAAL 942 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYVVLDEIPITAH KIDRAALP+PQI + TE+R P T TE R+AQLF LLG Sbjct 943 PDYMTPAAYVVLDEIPITAHQKIDRAALPQPQIGAGTEYRDPTTPTEHRIAQLFSGLLGH 1002 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS--- 1012 +RVG DDSFFDLGGHSL+ATKLV A+R GV++G+R++FE ATV LA +D L S Sbjct 1003 ERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELATVGLLAERVDQLSSGEL 1062 Query 1013 DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 RP+L HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D +A AA+ Sbjct 1063 TGTRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVG 1122 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPA-EVPVRCAAGSDAAWLRAELNNERGYVFDLET 1131 DVVARHEILRT Y E+ GVP+Q++ PP E+PVR G D WL+ +L+ ER + F+L+ Sbjct 1123 DVVARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDG 1182 Query 1132 DWPIRAALL--STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + PIR A+L + + VLSLVVHHIA DHWSAGVLF D++TAYRAR G+ PSWAPL V Sbjct 1183 ELPIRVAVLRVANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRV 1242 Query 1190 QYADYSVWQSALLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 QYADY+ WQ L D G + G QR+YW RQL GL +TGLRPDFPR + SG G++ Sbjct 1243 QYADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGES 1302 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 V+F + AA R KLA V R+LG+TEFMLLQ AVAVVLHKAGGGVD+P+G PVAGR+EA LD Sbjct 1303 VDFHIDAATRAKLADVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELD 1362 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 QLIGFF+NI+VLRNDL GNPTLRE+L+R R+ ALAAYAHQDLPFD+VV++V+P RSLSRN Sbjct 1363 QLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1422 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPTFDAAQADLSVNFF---ACGD- 1417 PLF +VVHVR+ + VI+T P G DT L+P FD A ADLSVNFF GD Sbjct 1423 PLFQVVVHVRDHLSATRVIETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGAGDI 1482 Query 1418 EYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 Y H+I+RT+LY R T +R A WLVR V AFAD DQ LR+V ++ A ++RIL + + Sbjct 1483 GYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSR 1542 Query 1478 GAGTAR 1483 GA R Sbjct 1543 GAQPPR 1548 Score = 416 bits (1068), Expect = 3e-113, Method: Compositional matrix adjust. Identities = 375/1095 (35%), Positives = 515/1095 (48%), Gaps = 106/1095 (9%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGV----- 56 WF D + NI + R+TG D+ L AV V RH ILRT Y V DGV Sbjct 1088 WFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILRTRY-VELDGVPYQVV 1146 Query 57 AQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTA-A 115 P V +R + D D Q+L A+R C FEL + P+R+ V+R A A Sbjct 1147 GPPGVEIPVR----REDGPDDPWLQQQLD----AERRHC--FELDGELPIRVAVLRVANA 1196 Query 116 DEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP--------------- 160 EHVL LV HHIA D S V F D+ AY RA G + P P Sbjct 1197 AEHVLSLVVHHIASDHWSAGVLFADVMTAY-RARRGGE-APSWAPLRVQYADYAAWQRTF 1254 Query 161 -SAASGPDTT--EADLNYWRAIMADPPEPLEL-PGPAGTCVPTSWRAARATLRLPADTAA 216 A G ++ A YW +A PE L P VP S + A T A Sbjct 1255 LGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVP-SGDGESVDFHIDAATRA 1313 Query 217 RVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVA 275 ++A + + G T +M+L A ++H+ D + PV R D IG+F N + Sbjct 1314 KLADVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQLIGFFVNILV 1373 Query 276 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFRE 335 +R + RELL R+ A A+AHQ + DRVV ++P R + +V R+ Sbjct 1374 LRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRD 1433 Query 336 -----------PDGGGFNPPGIECERYDLRSNITQLPLGFMVEF---DRAGVLVEAEHLV 381 P GG + C D ++ L V F D AG + HL+ Sbjct 1434 HLSATRVIETAPVGG--DGQDTVCTSLDPVFDMAHADLS--VNFFGTDGAGDIGYNCHLI 1489 Query 382 EILEPALAKQMLRHFGVLLDNALAAPDN---TLSGLALMDERDAAR-LREVSRGER--FD 435 + + R G L+ A D+ TL +AL+D + R LR+ SRG + D Sbjct 1490 FRTDLYRRTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSRGAQPPRD 1549 Query 436 TPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVL 495 P +T+ +L+ + D AV +H Y L+ S+ L L+++G+G V + Sbjct 1550 RP-RTIPELLQASRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVGPGTLVGLS 1608 Query 496 LDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT------------ 543 +S +L+V + ++K+GA Y PVDP YP R F+L D +V+ T Sbjct 1609 TRRSIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVATVEAVDTMPGLPG 1668 Query 544 ---------PVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVA 594 VR L DP A R+RP PD+ YL++TSG+TG PKG HR +A Sbjct 1669 VELLSLDDPQVRALVDRDDVDPR-AGRLRPPHPDDPMYLVFTSGSTGKPKGAVGTHRSMA 1727 Query 595 EYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTAL 654 W Y D L AS +F E+ LA GA M++ D L L Sbjct 1728 ARLDWQLRHYPPRTDDVRLAQASITFLEGGMEMLAGLAAGATMILADDAEHRDPEALGEL 1787 Query 655 LRDEGITAMHFVPSLLGLFL-SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDA---- 709 + + + VPSL+ L S P R+L R+ GGEP+ + + + D Sbjct 1788 MHRHSVAQVTAVPSLVSALLDSRPDAV--RSLSRLVCGGEPVSTSLLQRLVSVCDEADGG 1845 Query 710 ---LLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 LL+N G TET SR GP +G+P +LLDD L+PVP GV+GE Sbjct 1846 GPELLNNI-GSTETSGAVSR----GPLSPPNPLVGKPVPGAQAYLLDDGLRPVPVGVVGE 1900 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDLARRNADGDIEFVGRADEQ 824 +Y G +A GY +R GLTA RFVA+PF PGSR+YRSGDLAR DG +EFVGR+D Q Sbjct 1901 LYYAGDQLARGYWKRPGLTAARFVANPFGAEPGSRLYRSGDLARWTEDGQLEFVGRSDHQ 1960 Query 825 VKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDL 884 V++RGFR+EL +V AA+A V A ++ G SL GYV P A+ Sbjct 1961 VQVRGFRVELAEVEAALAGADGVAAAAARTWEV-HGGTSLAGYVVPQRPIADEAEKAAFA 2019 Query 885 DRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERR 944 ++RA +AA LP YM+P++ VLD +P T GK++R LP P +++ +T TER Sbjct 2020 AQVRAEIAATLPGYMMPSSLTVLDALPKTESGKLNRPGLPRPAVSTGGRTEPARTDTERA 2079 Query 945 LAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALA 1004 LA +F ELL VG D FF LGG S+L+ +L + R A G+ V R IFE TV LA Sbjct 2080 LANVFAELLSTPEVGRFDDFFALGGDSILSVQLASRARAA-GLPVSPRMIFENPTVQQLA 2138 Query 1005 GHIDTLDSDSARPRL 1019 +D L + + RL Sbjct 2139 AALDALGDNDSDGRL 2153 Score = 115 bits (289), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 112/356 (32%), Positives = 155/356 (44%), Gaps = 45/356 (12%) Query 1024 HDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRT 1083 HD P R+S Q R WF D +A+ NI + L G DT A+ V ARH +L T Sbjct 37 HDEP-RMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHT 95 Query 1084 VYREIG-GVPHQI----IQPPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETDWPIR 1136 Y G P + ++P A LR ++ +R + FDL D P+R Sbjct 96 TYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLR 155 Query 1137 --AALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1194 AA L+ E +L + HHIA D S F DL AY A P + D Sbjct 156 VTAARLADDELMLL-ITAHHIAWDDGSWAPFFADLTRAYTA------------PGDF-DA 201 Query 1195 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVE------- 1247 + L D I DYW L D P P L G +V Sbjct 202 TPVVPDLSADPTAIRREDLDYW----------RPLMADLPEPLELPGPNGSVVPSTWRAQ 251 Query 1248 ---FRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANL 1304 L A I D+ AA++R+ G T +M+L AA A ++H+ G D + APV R A Sbjct 252 RAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAAT- 310 Query 1305 DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 + +IG++ N VV+R + + + RE+L +TR A+ A+AH D +V NP R Sbjct 311 ENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR 366 Score = 115 bits (287), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 59/113 (53%), Positives = 81/113 (72%), Gaps = 6/113 (5%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EPA T+TERALA + A++L EVGR+DDFF LGGDSIL+ Q+A+RAR G+P++ RM+F Sbjct 2070 EPARTDTERALANVFAELLSTPEVGRFDDFFALGGDSILSVQLASRARAAGLPVSPRMIF 2129 Query 1632 EHPVLCELAAAVDA------KPHVEAEPDDKHHAPMSTSGLSPDELSALTASW 1678 E+P + +LAAA+DA ++ +P D PMSTSGLS +L+A+T W Sbjct 2130 ENPTVQQLAAALDALGDNDSDGRLDDQPADTRFEPMSTSGLSASDLAAVTQLW 2182 Score = 91.3 bits (225), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 43/74 (59%), Positives = 52/74 (71%), Gaps = 0/74 (0%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 A+ YLLDD L+PVPVGVVG++YY G RP TA RFVA+PF A+PGSRLYR+G Sbjct 1881 AQAYLLDDGLRPVPVGVVGELYYAGDQLARGYWKRPGLTAARFVANPFGAEPGSRLYRSG 1940 Query 1542 ERGVWKADGQLELL 1555 + W DGQLE + Sbjct 1941 DLARWTEDGQLEFV 1954 Score = 67.8 bits (164), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 35/75 (47%), Positives = 47/75 (63%), Gaps = 2/75 (2%) Query 1481 TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 RVYLLD+AL+PVP GV+G++Y G RP TA RFVADPF+ G R+YR+ Sbjct 796 NTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSR--GGRMYRS 853 Query 1541 GERGVWKADGQLELL 1555 G+ A+G +E + Sbjct 854 GDLARRNANGDIEFV 868 Score = 40.0 bits (92), Expect = 3.9, Method: Compositional matrix adjust. Identities = 26/70 (38%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TE +A + + +L VG D FF+LGG S++AT++ R + G+ + R VFE Sbjct 986 TPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELA 1045 Query 1635 VLCELAAAVD 1644 + LA VD Sbjct 1046 TVGLLAERVD 1055 >gi|41408271|ref|NP_961107.1| MbtE [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396626|gb|AAS04490.1| MbtE [Mycobacterium avium subsp. paratuberculosis K-10] Length=1759 Score = 1919 bits (4971), Expect = 0.0, Method: Compositional matrix adjust. Identities = 981/1506 (66%), Positives = 1162/1506 (78%), Gaps = 29/1506 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLNICVSYR+TG +D RL AV+AVA RH +L TTY D+G +P Sbjct 49 MWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHTTYDTTDEGDPRPV 108 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + ADLRP W ++DL+ L+++A+RLRL+VLAQR+F PF+LS+D+PLR+T R A +E +L Sbjct 109 LRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAARLADEELML 168 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDDGSW FF DLT+AY+ A D P +A DL+YWR +M Sbjct 169 LITAHHIAWDDGSWAPFFADLTRAYA-APGDFDTTPVVPDLSADPTAIRREDLDYWRPLM 227 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPGP G+ VP++WRA RA LPA+ R A +A+ TG TPYMVL+AAF AL Sbjct 228 ADLPEPLELPGPNGSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAAL 287 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DFLVAAPVLNRGA TE+ IGY+GNTV +RLRPQS SFRELL TRD A GA Sbjct 288 VHRYTGSTDFLVAAPVLNRGAATENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGA 347 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAH R +LD +VRE NPDRRHGA+RMTRVSFG REPDG F PPG+ CER DLR + QL Sbjct 348 FAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGASFCPPGVRCERGDLRGHFNQL 407 Query 361 PLGFMVEFDR-----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 PL M+E +R G LVEAE+LVE+L+ L +QMLRH+ LLD+ L+ PD TLS A Sbjct 408 PLSLMIELNRTPDGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACA 467 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM + DA LR VS GE+F TP TL +LV+ + RTPDA AVVYEG +TY D+ E SN Sbjct 468 LMSDADAEWLRAVSTGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESN 527 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ HWLIE+G+G+EDRVAVLLDKSP+L++TALGV+K+G VY+PVDP+YPQDRL+FIL D Sbjct 528 RVAHWLIERGVGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDA 587 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV +LA Y + PT+ +RPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 588 DAKLVLREPVTDLADYPATAPTEL--LRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAE 645 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY +D+TDRLLQVASPSFDVSI EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 646 YFVWFGDEYRIDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELL 705 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPGVSQWRTL+RVPIGGE LPGE+ADKFHATFDA L+NFY Sbjct 706 AREGITSMHFVPSLLGLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFY 765 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTR+VPIGRPKINT ++LLD++LQPVP GVIGEIYI GTHVA Sbjct 766 GPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVA 825 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR LTAERFVADPF+ G RMYRSGDLARRNA+GDIEFVGRADEQVKIRGFRIELG Sbjct 826 HGYHRRPQLTAERFVADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELG 885 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLP+LGKSLVGYVTPA G VD++RIRARVAAAL Sbjct 886 EIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGAGTET---VDVERIRARVAAAL 942 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYVVLDEIPITAH KIDRAALP+PQI + TE+R P T TE R+AQLF LLG Sbjct 943 PDYMTPAAYVVLDEIPITAHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGH 1002 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS--- 1012 +RVG DDSFFDLGGHSL+ATKLV A+R GV++G+R++FE ATV LA +D L S Sbjct 1003 ERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELATVGLLAERVDQLSSGEL 1062 Query 1013 DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 RP+L HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D +A AA+ Sbjct 1063 TGTRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVG 1122 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPA-EVPVRCAAGSDAAWLRAELNNERGYVFDLET 1131 DVVARHEILRT Y E+ GVP+Q++ PP E+PVR G D WL+ +L+ ER + F+L+ Sbjct 1123 DVVARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDG 1182 Query 1132 DWPIRAALL--STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + PIR A+L + + VLSLVVHHIA DHWSAGVLF D++TAYRAR G+ PSWAPL V Sbjct 1183 ELPIRVAVLRVANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRV 1242 Query 1190 QYADYSVWQSALLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 QYADY+ WQ L D G + G QR+YW RQL GL +TGLRPDFPR + SG G++ Sbjct 1243 QYADYAAWQRTFLGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVPSGDGES 1302 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 V+F + AA R KLA V R+LG+TEFMLLQ AVAVVLHKAGGGVD+P+G PVAGR+EA LD Sbjct 1303 VDFHIDAATRVKLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELD 1362 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 QLIGFF+NI+VLRNDL GNPTLRE+L+R R+ ALAAYAHQDLPFD+VV++V+P RSLSRN Sbjct 1363 QLIGFFVNILVLRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1422 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPTFDAAQADLSVNFF----ACGD 1417 PLF +VVHVR+ + VI+T P G DT L+P FD A ADLSVNFF A Sbjct 1423 PLFQVVVHVRDHLSATRVIETAPVGGDGQDTVCTSLDPVFDMAHADLSVNFFGTDGASDI 1482 Query 1418 EYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 Y H+I+RT+LY R T +R A WLVR V AFAD DQ LR+V ++ A ++RIL + + Sbjct 1483 GYNCHLIFRTDLYRRTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSR 1542 Query 1478 GAGTAR 1483 GA R Sbjct 1543 GAQPPR 1548 Score = 151 bits (381), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 177/588 (31%), Positives = 254/588 (44%), Gaps = 65/588 (11%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGV----- 56 WF D + NI + R+TG D+ L AV V RH ILRT Y V DGV Sbjct 1088 WFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVGDVVARHEILRTRY-VELDGVPYQVV 1146 Query 57 AQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTA-A 115 P V +R + D D Q+L A+R C FEL + P+R+ V+R A A Sbjct 1147 GPPGVEIPVR----REDGPDDPWLQQQLD----AERRHC--FELDGELPIRVAVLRVANA 1196 Query 116 DEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP--------------- 160 EHVL LV HHIA D S V F D+ AY RA G + P P Sbjct 1197 AEHVLSLVVHHIASDHWSAGVLFADVMTAY-RARRGGE-APSWAPLRVQYADYAAWQRTF 1254 Query 161 -SAASGPDTT--EADLNYWRAIMADPPEPLEL-PGPAGTCVPTSWRAARATLRLPADTAA 216 A G ++ A YW +A PE L P VP S + A T Sbjct 1255 LGDAGGQESAVAGAQREYWTRQLAGLPEDTGLRPDFPRQPVP-SGDGESVDFHIDAATRV 1313 Query 217 RVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVA 275 ++A + + G T +M+L A ++H+ D + PV R D IG+F N + Sbjct 1314 KLAEVCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQLIGFFVNILV 1373 Query 276 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFRE 335 +R + RELL R+ A A+AHQ + DRVV ++P R + +V R+ Sbjct 1374 LRNDLDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRD 1433 Query 336 -----------PDGGGFNPPGIECERYDLRSNITQLPLGFMVEF---DRAGVLVEAEHLV 381 P GG + C D ++ L V F D A + HL+ Sbjct 1434 HLSATRVIETAPVGG--DGQDTVCTSLDPVFDMAHADLS--VNFFGTDGASDIGYNCHLI 1489 Query 382 EILEPALAKQMLRHFGVLLDNALAAPDN---TLSGLALMDERDAAR-LREVSRGER--FD 435 + + R G L+ A D+ TL +AL+D + R LR+ SRG + D Sbjct 1490 FRTDLYRRTTIERLAGWLVRAVTAFADDLDQTLRDVALIDAGEQQRILRQWSRGAQPPRD 1549 Query 436 TPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVL 495 P +T+ +L+ + D AV +H Y L+ S+ L L+++G+G V + Sbjct 1550 RP-RTIPELLQPTRSLGADRIAVRCGAEHIDYPALHRRSDNLAALLVDRGVGPGTLVGLS 1608 Query 496 LDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT 543 + +L+V + ++K+GA Y PVDP YP R F+L D +V+ T Sbjct 1609 TRRGIELVVALVAIMKAGAGYFPVDPGYPSARKQFMLDDVRPPVVVAT 1656 Score = 116 bits (290), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 113/356 (32%), Positives = 158/356 (45%), Gaps = 45/356 (12%) Query 1024 HDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRT 1083 HD P R+S Q R WF D +A+ NI + L G DT A+ V ARH +L T Sbjct 37 HDEP-RMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHT 95 Query 1084 VYREIG-GVPHQI----IQPPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETDWPIR 1136 Y G P + ++P A LR ++ +R + FDL D P+R Sbjct 96 TYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLR 155 Query 1137 --AALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1194 AA L+ E+ +L + HHIA D S F DL AY A P + D Sbjct 156 VTAARLAD-EELMLLITAHHIAWDDGSWAPFFADLTRAYAA------------PGDF-DT 201 Query 1195 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV---EFR-- 1249 + L D I DYW L D P P L G +V +R Sbjct 202 TPVVPDLSADPTAIRREDLDYW----------RPLMADLPEPLELPGPNGSVVPSTWRAQ 251 Query 1250 -----LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANL 1304 L A I D+ AA++R+ G T +M+L AA A ++H+ G D + APV R A Sbjct 252 RAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAAT- 310 Query 1305 DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 + +IG++ N VV+R + + + RE+L +TR A+ A+AH D +V NP R Sbjct 311 ENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR 366 Score = 67.8 bits (164), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 35/75 (47%), Positives = 47/75 (63%), Gaps = 2/75 (2%) Query 1481 TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 RVYLLD+AL+PVP GV+G++Y G RP TA RFVADPF+ G R+YR+ Sbjct 796 NTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSR--GGRMYRS 853 Query 1541 GERGVWKADGQLELL 1555 G+ A+G +E + Sbjct 854 GDLARRNANGDIEFV 868 Score = 40.0 bits (92), Expect = 3.7, Method: Compositional matrix adjust. Identities = 26/70 (38%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TE +A + + +L VG D FF+LGG S++AT++ R + G+ + R VFE Sbjct 986 TPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELA 1045 Query 1635 VLCELAAAVD 1644 + LA VD Sbjct 1046 TVGLLAERVD 1055 >gi|342857509|ref|ZP_08714165.1| linear gramicidin synthetase subunit D [Mycobacterium colombiense CECT 3035] gi|342134842|gb|EGT88008.1| linear gramicidin synthetase subunit D [Mycobacterium colombiense CECT 3035] Length=2196 Score = 1909 bits (4944), Expect = 0.0, Method: Compositional matrix adjust. Identities = 970/1498 (65%), Positives = 1151/1498 (77%), Gaps = 32/1498 (2%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLNICVSYR++G +D+ARL AV+AVA RH +L TTY +G P Sbjct 52 MWFVQSVDPDSALLNICVSYRLSGTVDIARLHRAVDAVAARHPVLHTTYATDGEGDPHPV 111 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + ADLRP W ++DL L+ +A+RLRL+VLAQR+F PF+LS+D+PLR+TV R A DE +L Sbjct 112 MRADLRPEWAEHDLARLADQARRLRLDVLAQRDFRRPFDLSKDSPLRVTVARLADDELML 171 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDDGSW FF DLT+AY+ G G R +AA +ADL+YWR M Sbjct 172 LITAHHIAWDDGSWAPFFADLTRAYTDP-AGFAHGEVRRDTAADATAIRQADLDYWRPRM 230 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPGP G+ VPT+WRA RA +L ADT AR A +A+ TG TPYMVL+AAF AL Sbjct 231 ADLPEPLELPGPNGSVVPTAWRAQRAVAQLSADTVARTAALARETGATPYMVLMAAFAAL 290 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DFLVAAPVLNRG GTED IGY+GNTV +RLRP+ +FRELL TR+ A GA Sbjct 291 VHRYTQSTDFLVAAPVLNRGLGTEDVIGYYGNTVVIRLRPRPHQTFRELLAETREDAVGA 350 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAH R +LD +VRE NPDRRHGA+RMTRVSFG REPDG GF PPG+ CER +LR + QL Sbjct 351 FAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGAGFCPPGVRCERGELRGHFNQL 410 Query 361 PLGFMVEFDR-----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 PL MVE DR LVEAE+LVE+++ L +Q+LRH+ LLD L+ PD +S A Sbjct 411 PLSLMVELDRTPDGSGAGLVEAEYLVEVMDQQLVEQLLRHYAALLDGLLSDPDANISACA 470 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM + DA LR VS GE+F TP TL LV+ + TP+A AVVYEG+ + Y +++E SN Sbjct 471 LMSDDDAEWLRAVSTGEKFVTPASTLPALVSRRARLTPEAVAVVYEGRAYPYREIDEESN 530 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 RL HWLIEQGIG+EDRVAVLLDKSP+L++TALGV+K+G VY+PVDP+YPQDRL FIL D Sbjct 531 RLAHWLIEQGIGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPQDRLSFILEDA 590 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV + A Y + PT IRPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 591 DAKLVLREPVTDAARYPASAPTAL--IRPLSPHNTAYLIYTSGSTGLPKGVPVPHAPIAE 648 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY +DDTDRLLQVASPSFDVS+ EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 649 YFVWFGDEYRIDDTDRLLQVASPSFDVSMGEIFGTLIMGARLVIPRPDGLRDIGYLTDLL 708 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPGVSQWRTL+RVPIGGE LPGE+ADKFHATFDA LHNFY Sbjct 709 AREGITSMHFVPSLLGLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLHNFY 768 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTR+VPIGRPKINT ++LLD++LQPVP GVIGEIYI GTHVA Sbjct 769 GPTETVVNCTSYPVEGAQGTRVVPIGRPKINTQVYLLDNALQPVPVGVIGEIYIAGTHVA 828 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR LTAERFVADPF PG RMYRSGDLARRNA+GDIEFVGRADEQVKIRGFRIELG Sbjct 829 HGYHRRPQLTAERFVADPFTPGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELG 888 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLP+LGKSLVGYVTPA G V+++RIRARVAAAL Sbjct 889 EIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGAGTET---VEVERIRARVAAAL 945 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYVVL+EIPITAH KIDRAALP+PQIA+ TE+R P T TERR+AQLF LLG Sbjct 946 PDYMTPAAYVVLEEIPITAHQKIDRAALPQPQIAAGTEYRDPTTPTERRIAQLFSGLLGH 1005 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDS- 1014 +RVG DDSFF+LGGHSL+ATKLV A+R GV++G+R++FE ATV ALA ID L + + Sbjct 1006 ERVGVDDSFFELGGHSLVATKLVTAIRAECGVEIGIRDVFELATVGALAERIDQLSAGAL 1065 Query 1015 --ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 +RPRL HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D + AA+ Sbjct 1066 TPSRPRLITTAHDEPMPLSASQLRSWFAYRVDGPSRVNNIPFAARLTGPWDIDTLIAAVG 1125 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPA-EVPVRCAAGSDAAWLRAELNNERGYVFDLET 1131 DVVARHEILRT Y E+ GVP+Q+++P VPVR G D AWL+ +L+ ER + F+L+ Sbjct 1126 DVVARHEILRTSYVELDGVPYQVVEPAGVAVPVRREEGPDDAWLQRQLDVERCHCFELDA 1185 Query 1132 DWPIRAALL--STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + PIR A+L + + VLSLVVHHIA DHWSAGVLF+D++TAYRAR G+ PSWAPL V Sbjct 1186 ELPIRVAVLRIANTAEHVLSLVVHHIASDHWSAGVLFSDVMTAYRARRGGEAPSWAPLRV 1245 Query 1190 QYADYSVWQSALL-------DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGA 1242 QYADY+ WQ L + I QR+YW RQL G+ +TGLRPDFPR + SG Sbjct 1246 QYADYAAWQRTFLGLDSEASGQESAIAADQREYWTRQLAGMPEDTGLRPDFPRQPVPSGE 1305 Query 1243 GDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEA 1302 G++V+F++ +A R KL + R+LG+TEFMLLQ AVAVVLHKAGGG D+P+G PVAGR+EA Sbjct 1306 GESVDFQIDSATRAKLGELCRELGITEFMLLQTAVAVVLHKAGGGTDIPLGTPVAGRTEA 1365 Query 1303 NLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSL 1362 LDQLIGFF+NI+VLRND+ GNPTLRE+L+R R+ ALAAYAHQDLPFD+VV++V+P RSL Sbjct 1366 ELDQLIGFFVNILVLRNDMDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSL 1425 Query 1363 SRNPLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPTFDAAQADLSVNFF---AC 1415 SRNPLF +VVHVR+ + VI+T G DT L+P FD A ADLSVNFF Sbjct 1426 SRNPLFQVVVHVRDHLSATRVIETAAPGSGEQDTVCTSLDPVFDMAHADLSVNFFGTDGS 1485 Query 1416 GD-EYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRIL 1472 GD Y +VIYRTELY R T +R ADWL RV+ FA DQ LR+V ++ A IL Sbjct 1486 GDIGYNCNVIYRTELYARTTIERLADWLARVLTEFAGDIDQTLRDVRLIDATEEHHIL 1543 Score = 395 bits (1015), Expect = 4e-107, Method: Compositional matrix adjust. Identities = 358/1097 (33%), Positives = 502/1097 (46%), Gaps = 115/1097 (10%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTV 61 WF D + NI + R+TG D+ L AV V RH ILRT+Y V DGV Sbjct 1091 WFAYRVDGPSRVNNIPFAARLTGPWDIDTLIAAVGDVVARHEILRTSY-VELDGVP---- 1145 Query 62 HADLRPGWTQYDLTDLSQRAQRLRLE-----VLAQREF----CAPFELSRDAPLRITVVR 112 Y + + + A +R E QR+ C FEL + P+R+ V+R Sbjct 1146 ----------YQVVEPAGVAVPVRREEGPDDAWLQRQLDVERCHCFELDAELPIRVAVLR 1195 Query 113 TA-ADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP----------- 160 A EHVL LV HHIA D S V F+D+ AY RA G + P P Sbjct 1196 IANTAEHVLSLVVHHIASDHWSAGVLFSDVMTAY-RARRGGE-APSWAPLRVQYADYAAW 1253 Query 161 --------SAASGPDTTEA--DLNYWRAIMADPPEPLEL-PGPAGTCVPTSWRAARATLR 209 S ASG ++ A YW +A PE L P VP S + Sbjct 1254 QRTFLGLDSEASGQESAIAADQREYWTRQLAGMPEDTGLRPDFPRQPVP-SGEGESVDFQ 1312 Query 210 LPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IG 268 + + T A++ + + G T +M+L A ++H+ D + PV R D IG Sbjct 1313 IDSATRAKLGELCRELGITEFMLLQTAVAVVLHKAGGGTDIPLGTPVAGRTEAELDQLIG 1372 Query 269 YFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTR 328 +F N + +R + RELL R+ A A+AHQ + DRVV ++P R + + Sbjct 1373 FFVNILVLRNDMDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQ 1432 Query 329 VSFGFR---------EPDGGGFNPPGIECERYDLRSNITQLPLGFMVEF---DRAGVL-- 374 V R E G C D ++ L V F D +G + Sbjct 1433 VVVHVRDHLSATRVIETAAPGSGEQDTVCTSLDPVFDMAHADLS--VNFFGTDGSGDIGY 1490 Query 375 -VEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAAR-LREVSRGE 432 + E+ +++ +L D TL + L+D + L++ SRGE Sbjct 1491 NCNVIYRTELYARTTIERLADWLARVLTEFAGDIDQTLRDVRLIDATEEHHILQDWSRGE 1550 Query 433 R--FDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSED 490 R D P +T+ +L+ D AV QH Y L+ S+ L L++ G+G Sbjct 1551 RPPHDRP-RTIPELLEPSRALGADRIAVRCGAQHIDYPALHRRSDNLAALLVKNGVGPGS 1609 Query 491 RVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC----------DAKLV 540 V + + +L+V + ++K+GA Y P+DP YP R F+L D + + Sbjct 1610 LVGLSTRRGIELVVALVAIMKAGAGYFPIDPGYPSARKQFMLDDVRPPVVVATVEAVETM 1669 Query 541 LRTPVRELAGYRSDDP-----TDADRIRPL-------RPDNTAYLIYTSGTTGLPKGVAV 588 + P EL DDP D+D + PL PD+ YL++TSG+TG PKG Sbjct 1670 PQVPGVELISL--DDPQVCAVVDSDDVDPLSTDARLPHPDDPMYLVFTSGSTGKPKGAVG 1727 Query 589 PHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDI 648 HR +A W Y D L AS +F E+ LA GA M++ D Sbjct 1728 THRSMAARLGWQLRHYPPRTDDVRLAQASITFLEGGMEMLAGLAAGATMILADDAEHRDP 1787 Query 649 GYLTALLRDEGITAMHFVPSLLGLFL-SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 L L+ + + VPSL+ + S P R L R+ GGEP+ + + + Sbjct 1788 EALGDLMSRHSVAQVTAVPSLVSALVDSRP--ESVRALSRLVCGGEPVSTALLQRLVSVC 1845 Query 708 -------DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVP 760 LL+N G TET SR ++ P +GRP +LLDD L+PVP Sbjct 1846 ADQDGAGTELLNNI-GSTETSGAVSRGRLGPPNPL----VGRPVPGAQAYLLDDGLRPVP 1900 Query 761 TGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDLARRNADGDIEFV 818 GV+GE+Y G +A GY +R GLTA RFVA+PF PGSR+YRSGDLAR DG +EFV Sbjct 1901 VGVVGELYYAGDQLARGYWKRPGLTAARFVANPFGAEPGSRLYRSGDLARWTEDGRLEFV 1960 Query 819 GRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPA 878 GR+D QV++RGFR+EL +V AA+A V A ++ G SL GYV P A Sbjct 1961 GRSDHQVQVRGFRVELAEVEAALAGAGGVAAAAARTWEM-HGGTSLAGYVVPQRPLADEA 2019 Query 879 DVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQ 938 ++RA +A LP YMLP++ VLD +P T GK++R LP P +++ + Sbjct 2020 AKAAFAGQVRAAIATTLPGYMLPSSLTVLDVLPKTESGKLNRPGLPPPSVSTGGLTEPAR 2079 Query 939 TATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFA 998 T TER LA +F ELL VG D FF LGG S+L+ +L + R A G+ V R IFE Sbjct 2080 TDTERALATVFAELLATPDVGRFDDFFTLGGDSILSVQLASRARAA-GLAVSPRMIFENP 2138 Query 999 TVTALAGHIDTLDSDSA 1015 TV LA +D + + A Sbjct 2139 TVQQLAAALDAMGDEGA 2155 Score = 111 bits (278), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 108/359 (31%), Positives = 155/359 (44%), Gaps = 42/359 (11%) Query 1020 TRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHE 1079 + V D R+S Q R WF D +A+ NI + L G D A+ V ARH Sbjct 35 SSVATDDQPRMSVGQHRMWFVQSVDPDSALLNICVSYRLSGTVDIARLHRAVDAVAARHP 94 Query 1080 ILRTVYREIG-GVPHQIIQP---PAEVPVRCAAGSDAA-WLRAELNNERGYV--FDLETD 1132 +L T Y G G PH +++ P A +D A LR ++ +R + FDL D Sbjct 95 VLHTTYATDGEGDPHPVMRADLRPEWAEHDLARLADQARRLRLDVLAQRDFRRPFDLSKD 154 Query 1133 WPIRAALLSTPEQTVLSLVV-HHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQY 1191 P+R + + ++ L+ HHIA D S F DL AY P + Sbjct 155 SPLRVTVARLADDELMLLITAHHIAWDDGSWAPFFADLTRAYTD------------PAGF 202 Query 1192 ADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV----- 1246 A V + D A I DYW ++ D P P L G +V Sbjct 203 AHGEVRRDTAADATA-IRQADLDYWRPRMA----------DLPEPLELPGPNGSVVPTAW 251 Query 1247 -----EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSE 1301 +L A + AA++R+ G T +M+L AA A ++H+ D + APV R Sbjct 252 RAQRAVAQLSADTVARTAALARETGATPYMVLMAAFAALVHRYTQSTDFLVAAPVLNRGL 311 Query 1302 ANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 D +IG++ N VV+R R + T RE+L TR+ A+ A+AH D +V NP R Sbjct 312 GTED-VIGYYGNTVVIRLRPRPHQTFRELLAETREDAVGAFAHSRADLDWLVRESNPDR 369 Score = 106 bits (265), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 59/110 (54%), Positives = 79/110 (72%), Gaps = 6/110 (5%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EPA T+TERALA + A++L +VGR+DDFF LGGDSIL+ Q+A+RAR G+ ++ RM+F Sbjct 2076 EPARTDTERALATVFAELLATPDVGRFDDFFTLGGDSILSVQLASRARAAGLAVSPRMIF 2135 Query 1632 EHPVLCELAAAVDAKPHVEA--EPD----DKHHAPMSTSGLSPDELSALT 1675 E+P + +LAAA+DA A E D D PMSTSGLSP +L+A+T Sbjct 2136 ENPTVQQLAAALDAMGDEGAVIEQDEGTADTRFEPMSTSGLSPSDLAAVT 2185 Score = 89.7 bits (221), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 42/74 (57%), Positives = 52/74 (71%), Gaps = 0/74 (0%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 A+ YLLDD L+PVPVGVVG++YY G RP TA RFVA+PF A+PGSRLYR+G Sbjct 1887 AQAYLLDDGLRPVPVGVVGELYYAGDQLARGYWKRPGLTAARFVANPFGAEPGSRLYRSG 1946 Query 1542 ERGVWKADGQLELL 1555 + W DG+LE + Sbjct 1947 DLARWTEDGRLEFV 1960 Score = 72.0 bits (175), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 36/73 (50%), Positives = 48/73 (66%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +VYLLD+AL+PVPVGV+G++Y G RP TA RFVADPF PG R+YR+G+ Sbjct 801 QVYLLDNALQPVPVGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFT--PGGRMYRSGD 858 Query 1543 RGVWKADGQLELL 1555 A+G +E + Sbjct 859 LARRNANGDIEFV 871 Score = 42.0 bits (97), Expect = 1.1, Method: Compositional matrix adjust. Identities = 26/70 (38%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TER +A + + +L VG D FF LGG S++AT++ R + G+ + R VFE Sbjct 989 TPTERRIAQLFSGLLGHERVGVDDSFFELGGHSLVATKLVTAIRAECGVEIGIRDVFELA 1048 Query 1635 VLCELAAAVD 1644 + LA +D Sbjct 1049 TVGALAERID 1058 >gi|254819401|ref|ZP_05224402.1| linear gramicidin synthetase subunit D [Mycobacterium intracellulare ATCC 13950] Length=2191 Score = 1895 bits (4910), Expect = 0.0, Method: Compositional matrix adjust. Identities = 971/1502 (65%), Positives = 1156/1502 (77%), Gaps = 29/1502 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLNICVSYR+ G +D ARL AV+AVA RH L TTY DG +P Sbjct 52 MWFVQSVDPDSALLNICVSYRLIGAVDAARLHRAVDAVAARHPALHTTYDTDGDGDPRPV 111 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V DL P W+++DL+ L+ +A+RLRL+VLAQR+F PF+LS+D+PLR+TV ADE ++ Sbjct 112 VRDDLHPEWSEHDLSGLADQARRLRLDVLAQRDFRRPFDLSKDSPLRVTVAHLGADELIM 171 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDDGSW FF DLT+AY+ D G P AA +ADL+YWR +M Sbjct 172 LITAHHIAWDDGSWAPFFADLTRAYTDPD-GFAAAPALPDLAADPTAIRQADLDYWRPLM 230 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPGP G+ VP++WRA RAT L AD R A +A+ TG TPYMVL+AAFGAL Sbjct 231 ADLPEPLELPGPNGSVVPSTWRAQRATAPLSADVVDRAAALARETGATPYMVLMAAFGAL 290 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DFL AAPVLNRG GTED IGY GNTV +RLRP+ +FRELL TRD A GA Sbjct 291 VHRYTQSTDFLFAAPVLNRGVGTEDVIGYHGNTVVVRLRPRPHQTFRELLAQTRDGAVGA 350 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAH R +LD +VRE NPDRRHGA+RMTRVSFG REPDG GF PPG+ CER +LR + QL Sbjct 351 FAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGAGFCPPGVRCERAELRGHFNQL 410 Query 361 PLGFMVEFDR-----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 PL MVE +R G ++EAE+LVE+L+ L +Q+LRH+ LLD+ L+ PD TLS A Sbjct 411 PLSLMVELNRTPDGLGGGVIEAEYLVEVLDQQLVQQLLRHYAALLDSVLSDPDVTLSACA 470 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM++ DA LR VS GE F TP TL +LV+ + RTPDA AVVYEG+ +TY +++E SN Sbjct 471 LMNDEDAEWLRSVSTGEEFVTPASTLSELVSRRAARTPDAVAVVYEGRAYTYREIDEESN 530 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ HWLIEQGIG+EDRVAVLLDKSP+L++TALGV+K+G VY+PVDP+YP+DRL FIL D Sbjct 531 RVAHWLIEQGIGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPEDRLSFILGDA 590 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV L GY + PT +RPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 591 DAKLVLREPVSGLEGYPTTAPTAL--LRPLSPQNTAYLIYTSGSTGLPKGVPVPHAPIAE 648 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY +D+TDRLLQVASPSFDVS+ EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 649 YFVWFGDEYRIDETDRLLQVASPSFDVSMGEIFGTLIMGARLVIPRPDGLRDIGYLTDLL 708 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPGVSQWRTL+RVPIGGE LPGE+ADKFHATFDA LHNFY Sbjct 709 AREGITSMHFVPSLLGLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLHNFY 768 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTRIVPIGRPKINT ++LLD++L+ VP GVIGEIYI GTHVA Sbjct 769 GPTETVVNCTSYPVEGAQGTRIVPIGRPKINTQVYLLDNALRLVPAGVIGEIYIAGTHVA 828 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR LTAERFVADPF PG RMYRSGDLARRNA+GDIEFVGRADEQVKIRGFRIELG Sbjct 829 HGYHRRPQLTAERFVADPFTPGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELG 888 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLP+LGKSLVGYVTPA +G VD++RIRARVAAAL Sbjct 889 EIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPA---EGAGTETVDVERIRARVAAAL 945 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYVVLDEIPITAH KIDRAALP+PQ+A+ TE+R P T TE R+AQLF LLG Sbjct 946 PDYMTPAAYVVLDEIPITAHQKIDRAALPQPQLAAGTEYRDPTTPTEIRVAQLFSGLLGH 1005 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS--- 1012 +RVG DDSFFDLGGHSL+ATKLV A+R GV++G+R++FE ATV LA ID L S Sbjct 1006 ERVGVDDSFFDLGGHSLVATKLVTAIRAECGVELGIRDVFELATVGLLAERIDQLSSGQL 1065 Query 1013 DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 +RPRL HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D +A AA+ Sbjct 1066 TQSRPRLIATAHDEPMPLSASQLRSWFAYRLDGPSPVNNIPFAAKLTGPWDIDALIAAVG 1125 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPA-EVPVRCAAGSDAAWLRAELNNERGYVFDLET 1131 DV+ARHEILRT Y E+ GVP+Q++ P EVPVR A G AWL+ +L+ ER + F+L++ Sbjct 1126 DVLARHEILRTSYVELDGVPYQVVGPAGVEVPVRRAEGVGEAWLQEQLDIERRHCFELDS 1185 Query 1132 DWPIRAALLSTP--EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + PIR A+L T ++ VLS+VVHHIA DHWSAGVLF+D++TAYRAR G+ PSWAPL V Sbjct 1186 ELPIRVAVLRTENADEHVLSVVVHHIASDHWSAGVLFSDVMTAYRARRGGEAPSWAPLRV 1245 Query 1190 QYADYSVWQSALLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 QYADY+ WQ L D +G I QR+YW R+L GL +TGLRPDFPR + SG G++ Sbjct 1246 QYADYAAWQRTFLGDASGQESAIAAEQREYWTRKLAGLPEDTGLRPDFPRQPVPSGEGES 1305 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 V+F++ +A R KL + R+LG+TEFMLLQ AVAVVLHKAGGGVD+P+G PVAGR+EA LD Sbjct 1306 VDFQIDSATRAKLGELCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELD 1365 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 QLIGFF+NI+VLRND+ GNPTLRE+L+R R+ ALAAYAHQDLPFD+VV++V+P RSLSRN Sbjct 1366 QLIGFFVNILVLRNDMDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1425 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPTFDAAQADLSVNFFACGDE--- 1418 PLF +VVHVR+ + VI+T P G DT L+P FD A ADLSVNFF Sbjct 1426 PLFQVVVHVRDHLSATRVIETAPAGGDGRDTVCTSLDPIFDMAHADLSVNFFGTDGTDDV 1485 Query 1419 -YRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 Y +VI+RTELY R T +R A WL R V FA+ D LR+V ++ A + RIL + Sbjct 1486 GYNCNVIFRTELYARTTIERLAQWLSRAVAVFAEDLDLSLRDVALIDAGEQHRILQDWSR 1545 Query 1478 GA 1479 GA Sbjct 1546 GA 1547 Score = 384 bits (987), Expect = 7e-104, Method: Compositional matrix adjust. Identities = 358/1095 (33%), Positives = 498/1095 (46%), Gaps = 116/1095 (10%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYP---------VG 52 WF D + NI + ++TG D+ L AV V RH ILRT+Y VG Sbjct 1091 WFAYRLDGPSPVNNIPFAAKLTGPWDIDALIAAVGDVLARHEILRTSYVELDGVPYQVVG 1150 Query 53 DDGVAQPTVHAD-LRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVV 111 GV P A+ + W Q L +R C FEL + P+R+ V+ Sbjct 1151 PAGVEVPVRRAEGVGEAWLQEQLD--------------IERRHC--FELDSELPIRVAVL 1194 Query 112 RTA-ADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP---------- 160 RT ADEHVL +V HHIA D S V F+D+ AY RA G + P P Sbjct 1195 RTENADEHVLSVVVHHIASDHWSAGVLFSDVMTAY-RARRGGE-APSWAPLRVQYADYAA 1252 Query 161 ------SAASGPDTTEA--DLNYWRAIMADPPEPLEL-PGPAGTCVPTSWRAARATLRLP 211 ASG ++ A YW +A PE L P VP S ++ Sbjct 1253 WQRTFLGDASGQESAIAAEQREYWTRKLAGLPEDTGLRPDFPRQPVP-SGEGESVDFQID 1311 Query 212 ADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYF 270 + T A++ + + G T +M+L A ++H+ D + PV R D IG+F Sbjct 1312 SATRAKLGELCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQLIGFF 1371 Query 271 GNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVS 330 N + +R + RELL R+ A A+AHQ + DRVV ++P R + +V Sbjct 1372 VNILVLRNDMDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVV 1431 Query 331 FGFRE-----------PDGGGFNP-------PGIECERYDLRSNITQLPLGFMVEFDRAG 372 R+ P GG P + DL N V ++ Sbjct 1432 VHVRDHLSATRVIETAPAGGDGRDTVCTSLDPIFDMAHADLSVNFFGTDGTDDVGYN-CN 1490 Query 373 VLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAAR-LREVSRG 431 V+ E LA+ + R V ++ D +L +AL+D + R L++ SRG Sbjct 1491 VIFRTELYARTTIERLAQWLSRAVAVFAEDL----DLSLRDVALIDAGEQHRILQDWSRG 1546 Query 432 ER--FDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSE 489 D P +T+ +L+ D AV + Y L+ S+ L L + G G Sbjct 1547 APAPHDRP-RTIPELLEPSRAWDADRIAVRCGDERIDYPALHRRSDNLAALLAKNGAGPG 1605 Query 490 DRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP----- 544 V + +S DL+V + ++K+GA Y P+DP YP R F+L D +V+ T Sbjct 1606 ALVGLSTRRSIDLVVALVAIMKAGAGYFPIDPGYPLARKQFMLEDVAPPVVVATTEAVAT 1665 Query 545 ----------------VRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAV 588 VR+L DP D RP PD+ YL++TSG+TG PKG Sbjct 1666 MPHVAGVELISLDDPHVRDLVDSDDVDPQSRDLPRP-HPDDPMYLVFTSGSTGKPKGAVG 1724 Query 589 PHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDI 648 HR +A W Y D L AS +F E+ LA GA M++ D Sbjct 1725 THRSMAARLDWQLRHYPPRTEDVRLAQASITFLEGGMEMLAGLAAGATMILADDDEHRDP 1784 Query 649 GYLTALLRDEGITAMHFVPSLLGLFL-SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 L L+ + + VPSL+ + S P R L R+ GGEP+ + + + Sbjct 1785 EALGELMTRYSVAQVTAVPSLVSALVDSRPDAV--RALSRLVCGGEPVSTSLLQRLVSVC 1842 Query 708 -----DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTG 762 LL+N G TET SR GP G +G+P +LLDD L+PVP G Sbjct 1843 ADDGATELLNNI-GSTETSGAVSR----GPLGLPNPLVGKPVPGAQAYLLDDGLRPVPVG 1897 Query 763 VIGEIYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDLARRNADGDIEFVGR 820 V+GE+Y G +A GY +R LTA RFVA+P+ PGSR+YRSGDLAR DG +EFVGR Sbjct 1898 VVGELYYAGDQLARGYWKRPALTATRFVANPYGGEPGSRLYRSGDLARWTEDGQLEFVGR 1957 Query 821 ADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADV 880 +D QV++RGFR+EL +V AA+A V A ++ G SL GYV P D Sbjct 1958 SDHQVQVRGFRVELAEVEAALAAADGVAAAAARTWEV-HGGTSLAGYVVPQRPIVDDVDK 2016 Query 881 GVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTA 940 +RA +A LP YM+P++ VLD +P T GK++R LP P +++ +T Sbjct 2017 AAFAGEVRAAIATTLPGYMMPSSLTVLDVLPKTESGKLNRPGLPLPAVSTGGLTEPARTD 2076 Query 941 TERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATV 1000 TER LA++F ELL VG D FF LGG S+L+ +L + R A G+ V R IFE TV Sbjct 2077 TERALAKVFAELLSTPEVGRFDDFFALGGDSILSVQLASRAR-AVGLAVSPRMIFENPTV 2135 Query 1001 TALAGHIDTLDSDSA 1015 LA +D L + A Sbjct 2136 QQLAAAVDALGNGQA 2150 Score = 110 bits (274), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 59/113 (53%), Positives = 81/113 (72%), Gaps = 6/113 (5%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EPA T+TERALA + A++L EVGR+DDFF LGGDSIL+ Q+A+RAR G+ ++ RM+F Sbjct 2071 EPARTDTERALAKVFAELLSTPEVGRFDDFFALGGDSILSVQLASRARAVGLAVSPRMIF 2130 Query 1632 EHPVLCELAAAVDAKPHVEAEPD------DKHHAPMSTSGLSPDELSALTASW 1678 E+P + +LAAAVDA + +A+ + D PMSTSGLS +L+A+T W Sbjct 2131 ENPTVQQLAAAVDALGNGQADTERDDQAADVRFEPMSTSGLSSTDLAAVTQLW 2183 Score = 101 bits (252), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 104/355 (30%), Positives = 151/355 (43%), Gaps = 43/355 (12%) Query 1024 HDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRT 1083 +D P R+S+ Q R WF D +A+ NI + L G D A+ V ARH L T Sbjct 40 YDEP-RMSAGQHRMWFVQSVDPDSALLNICVSYRLIGAVDAARLHRAVDAVAARHPALHT 98 Query 1084 VYREIG-GVPHQIIQ----PPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETDWPIR 1136 Y G G P +++ P A LR ++ +R + FDL D P+R Sbjct 99 TYDTDGDGDPRPVVRDDLHPEWSEHDLSGLADQARRLRLDVLAQRDFRRPFDLSKDSPLR 158 Query 1137 AALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYS 1195 + ++ ++ + HHIA D S F DL AY G + A + + Sbjct 159 VTVAHLGADELIMLITAHHIAWDDGSWAPFFADLTRAY-TDPDGFAAAPALPDLAADPTA 217 Query 1196 VWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV---EFR--- 1249 + Q+ L DYW L D P P L G +V +R Sbjct 218 IRQADL------------DYW----------RPLMADLPEPLELPGPNGSVVPSTWRAQR 255 Query 1250 ----LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 L A + D+ AA++R+ G T +M+L AA ++H+ D APV R D Sbjct 256 ATAPLSADVVDRAAALARETGATPYMVLMAAFGALVHRYTQSTDFLFAAPVLNRGVGTED 315 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 +IG+ N VV+R R + T RE+L +TR A+ A+AH D +V NP R Sbjct 316 -VIGYHGNTVVVRLRPRPHQTFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR 369 Score = 91.3 bits (225), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 42/74 (57%), Positives = 53/74 (72%), Gaps = 0/74 (0%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 A+ YLLDD L+PVPVGVVG++YY G RP+ TATRFVA+P+ +PGSRLYR+G Sbjct 1882 AQAYLLDDGLRPVPVGVVGELYYAGDQLARGYWKRPALTATRFVANPYGGEPGSRLYRSG 1941 Query 1542 ERGVWKADGQLELL 1555 + W DGQLE + Sbjct 1942 DLARWTEDGQLEFV 1955 Score = 66.2 bits (160), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 34/73 (47%), Positives = 46/73 (64%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +VYLLD+AL+ VP GV+G++Y G RP TA RFVADPF PG R+YR+G+ Sbjct 801 QVYLLDNALRLVPAGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFT--PGGRMYRSGD 858 Query 1543 RGVWKADGQLELL 1555 A+G +E + Sbjct 859 LARRNANGDIEFV 871 Score = 38.9 bits (89), Expect = 7.9, Method: Compositional matrix adjust. Identities = 26/70 (38%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TE +A + + +L VG D FF+LGG S++AT++ R + G+ L R VFE Sbjct 989 TPTEIRVAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVELGIRDVFELA 1048 Query 1635 VLCELAAAVD 1644 + LA +D Sbjct 1049 TVGLLAERID 1058 >gi|254774738|ref|ZP_05216254.1| linear gramicidin synthetase subunit D [Mycobacterium avium subsp. avium ATCC 25291] Length=2191 Score = 1880 bits (4870), Expect = 0.0, Method: Compositional matrix adjust. Identities = 968/1502 (65%), Positives = 1154/1502 (77%), Gaps = 29/1502 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLNICVSYR+ G +D ARL AV+AVA RH +L TTY +G +P Sbjct 52 MWFVQSVDPDSALLNICVSYRLIGAVDAARLHRAVDAVAARHPVLHTTYDTDGEGDPRPV 111 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V DL P W+++DL+ L+ +A+RLRL+VLAQR+F PF+LS+D+PLR+TV DE ++ Sbjct 112 VRDDLHPEWSEHDLSGLADQARRLRLDVLAQRDFRRPFDLSKDSPLRVTVAHLGGDELIM 171 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDDGSW FF DLT+AY+ D G P A +ADL+YWR +M Sbjct 172 LITAHHIAWDDGSWAPFFADLTRAYTDPD-GFAAAPALPDLATDPTAIRQADLDYWRPLM 230 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPGP G+ VPT+WRA RAT L AD R A +A+ TG TPYMVL+A FGAL Sbjct 231 ADLPEPLELPGPNGSVVPTTWRAQRATAPLSADVVDRAAALARETGATPYMVLMAVFGAL 290 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DFL AAPVLNRG GTED IGY+GNTV +RLRP+ +FRELL TRD A GA Sbjct 291 VHRYTQSTDFLFAAPVLNRGVGTEDVIGYYGNTVVVRLRPRPHQTFRELLAQTRDGAVGA 350 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAH R +LD +VRE NPDRRHGA+RMTRVSFG REPDG GF PPG+ CER +LR + QL Sbjct 351 FAHSRADLDWLVRESNPDRRHGADRMTRVSFGQREPDGAGFCPPGVRCERAELRGHFNQL 410 Query 361 PLGFMVEFDR-----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 PL MVE +R G ++EAE+LVE+L+ L +Q+LRH+ LLD+ L+ PD TLS A Sbjct 411 PLSLMVELNRTPDGLGGGVIEAEYLVEVLDQQLVQQLLRHYAALLDSVLSDPDVTLSACA 470 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM++ DA LR VS GE F TP TL +LV+ + RTPDA AVVYEG+ +TY +++E SN Sbjct 471 LMNDEDAEWLRSVSTGEEFVTPASTLSELVSRRAARTPDAVAVVYEGRAYTYREIDEESN 530 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ HWLIEQGIG+EDRVAVLLDKSP+L++TALGV+K+G VY+PVDP+YP+DRL FIL D Sbjct 531 RVAHWLIEQGIGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPEDRLSFILGDA 590 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV L Y + P A +RPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 591 DAKLVLREPVSGLGSYPTTAP--AALLRPLSPQNTAYLIYTSGSTGLPKGVPVPHAPIAE 648 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY +D+TDRLLQVASPSFDVS+ EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 649 YFVWFGDEYRIDETDRLLQVASPSFDVSMGEIFGTLIMGARLVIPRPDGLRDIGYLTDLL 708 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPG SQWRTL+RVPIGGE LPGE+ADKFHATFDA LHNFY Sbjct 709 AREGITSMHFVPSLLGLFLSLPGASQWRTLRRVPIGGEALPGEIADKFHATFDASLHNFY 768 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTRIVPIGRPKINT ++LLD++L+PVP GVIGEIYI GTHVA Sbjct 769 GPTETVVNCTSYPVEGAQGTRIVPIGRPKINTQVYLLDNALRPVPAGVIGEIYIAGTHVA 828 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR LTAERFVADPF PG RMYRSGDLARRNA+GDIEFVGRADEQVKIRGFRIELG Sbjct 829 HGYHRRPQLTAERFVADPFTPGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELG 888 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLP+LGKSLVGYVTPA +G VD++RIRARVAAAL Sbjct 889 EIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPA---EGAGTETVDVERIRARVAAAL 945 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYVVLDEIPITAH KIDRAALP+PQ+A+ TE+R P T TE R+AQLF LLG Sbjct 946 PDYMTPAAYVVLDEIPITAHQKIDRAALPQPQLAAGTEYRDPTTPTEIRVAQLFSGLLGH 1005 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS--- 1012 +RVG DDSFFDLGGHSL+ATKLV A+R GV++G+R++FE ATV LA ID L S Sbjct 1006 ERVGVDDSFFDLGGHSLVATKLVTAIRAECGVELGIRDVFELATVGLLAERIDQLSSGQL 1065 Query 1013 DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 +RPRL HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D +A AA+ Sbjct 1066 TQSRPRLIATAHDEPMPLSASQLRSWFAYRLDGPSPVNNIPFAAKLTGPWDIDALIAAVG 1125 Query 1073 DVVARHEILRTVYREIGGVPHQ-IIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLET 1131 DV+ARHEILRT Y E+ GVP+Q + EVPVR A G AWL+ +L+ ER + F+L++ Sbjct 1126 DVLARHEILRTSYVELDGVPYQVVGPVGVEVPVRRAEGVGEAWLQEQLDVERRHCFELDS 1185 Query 1132 DWPIRAALLSTP--EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + PIR A+L T ++ VLS+VVHHIA DHWSAGVLF+D++TAYRAR G+ PSWAPL V Sbjct 1186 ELPIRVAVLRTENADEHVLSVVVHHIASDHWSAGVLFSDVMTAYRARRGGEAPSWAPLRV 1245 Query 1190 QYADYSVWQSALLDDGAG----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 QYADY+ WQ L D +G I QR+YW R+L GL +TGLRPDFPR + SG G++ Sbjct 1246 QYADYAAWQRTFLGDASGQESAIAAEQREYWTRKLAGLPEDTGLRPDFPRQPVPSGEGES 1305 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 V+F++ +A R KL + R+LG+TEFMLLQ AVAVVLHKAGGGVD+P+G PVAGR+EA LD Sbjct 1306 VDFQIDSATRAKLGELCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELD 1365 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 QLIGFF+NI+VLRND+ GNPTLRE+L+R R+ ALAAYAHQDLPFD+VV++V+P RSLSRN Sbjct 1366 QLIGFFVNILVLRNDMDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRN 1425 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPTFDAAQADLSVNFFAC----GD 1417 PLF +VVHVR+ + VI+T P G DT L+P FD A ADLSVNFF G Sbjct 1426 PLFQVVVHVRDHLSATRVIETAPAGGDGRDTVCTSLDPIFDMAHADLSVNFFGTDGTDGV 1485 Query 1418 EYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 Y +VI+RTELY R T +R A WL R V AFA+ D LR+V ++ A + RIL + Sbjct 1486 GYNCNVIFRTELYARTTIERLAQWLSRAVAAFAEDLDLSLRDVALIDAGEQHRILQDWSR 1545 Query 1478 GA 1479 GA Sbjct 1546 GA 1547 Score = 373 bits (958), Expect = 2e-100, Method: Compositional matrix adjust. Identities = 352/1085 (33%), Positives = 497/1085 (46%), Gaps = 106/1085 (9%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTV 61 WF D + NI + ++TG D+ L AV V RH ILRT+Y V DGV V Sbjct 1091 WFAYRLDGPSPVNNIPFAAKLTGPWDIDALIAAVGDVLARHEILRTSY-VELDGVPYQVV 1149 Query 62 HADLRPGWTQYDLTDLSQRAQR-----LRLEVLAQREFCAPFELSRDAPLRITVVRTA-A 115 + +RA+ L+ ++ +R C FEL + P+R+ V+RT A Sbjct 1150 --------GPVGVEVPVRRAEGVGEAWLQEQLDVERRHC--FELDSELPIRVAVLRTENA 1199 Query 116 DEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP--------------- 160 DEHVL +V HHIA D S V F+D+ AY RA G + P P Sbjct 1200 DEHVLSVVVHHIASDHWSAGVLFSDVMTAY-RARRGGE-APSWAPLRVQYADYAAWQRTF 1257 Query 161 -SAASGPDTTEA--DLNYWRAIMADPPEPLEL-PGPAGTCVPTSWRAARATLRLPADTAA 216 ASG ++ A YW +A PE L P VP S ++ + T A Sbjct 1258 LGDASGQESAIAAEQREYWTRKLAGLPEDTGLRPDFPRQPVP-SGEGESVDFQIDSATRA 1316 Query 217 RVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVA 275 ++ + + G T +M+L A ++H+ D + PV R D IG+F N + Sbjct 1317 KLGELCRELGITEFMLLQTAVAVVLHKAGGGVDIPLGTPVAGRTEAELDQLIGFFVNILV 1376 Query 276 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFRE 335 +R + RELL R+ A A+AHQ + DRVV ++P R + +V R+ Sbjct 1377 LRNDMDGNPTLRELLKRARETALAAYAHQDLPFDRVVDSVSPVRSLSRNPLFQVVVHVRD 1436 Query 336 -----------PDGGGFNP-------PGIECERYDLRSNITQLPLGFMVEFDRAGVLVEA 377 P GG P + DL N V ++ V+ Sbjct 1437 HLSATRVIETAPAGGDGRDTVCTSLDPIFDMAHADLSVNFFGTDGTDGVGYN-CNVIFRT 1495 Query 378 EHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAAR-LREVSRGER--F 434 E LA+ + R ++ D +L +AL+D + R L++ SRG Sbjct 1496 ELYARTTIERLAQWLSRAVAAFAEDL----DLSLRDVALIDAGEQHRILQDWSRGAPAPH 1551 Query 435 DTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAV 494 D P +T+ +L+ D AV + Y L+ S+ L L G G V + Sbjct 1552 DRP-RTIPELLEPSRAWDADRIAVRCGDERIDYPALHRRSDNLAALLARSGAGPGALVGL 1610 Query 495 LLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP---------- 544 +S DL+V + ++K+GA Y P+DP YP R F+L D +V+ T Sbjct 1611 STRRSIDLVVALVAIMKAGAGYFPIDPGYPLARKQFMLDDVAPPVVVATTEAVATMPHVA 1670 Query 545 -----------VRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPV 593 VR+L DP D RP PD+ YL++TSG+TG PKG HR + Sbjct 1671 GVELISLDDPHVRDLVDSDDVDPQSRDLPRP-HPDDPMYLVFTSGSTGKPKGAVGTHRSM 1729 Query 594 AEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA 653 A W Y D L AS +F E+ LA GA M++ D L Sbjct 1730 AARLDWQLRHYPPRTEDVRLAQASITFLEGGMEMLAGLAAGATMILADDDEHRDPEALGE 1789 Query 654 LLRDEGITAMHFVPSLLGLFL-SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF----- 707 L+ + + VPSL+ + S P R L R+ GGEP+ + + + Sbjct 1790 LMTRYSVAQVTAVPSLVSALVDSRPDAV--RALSRLVCGGEPVSTSLLQRLVSVCADDGA 1847 Query 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 LL+N G TET R ++ P +G+P +LLDD L+PVP GV+GE+ Sbjct 1848 TELLNNI-GSTETSGAVCRGRLGLPNPL----VGKPVPGAQAYLLDDGLRPVPVGVVGEL 1902 Query 768 YIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDLARRNADGDIEFVGRADEQV 825 Y G +A GY +R LTA RFVA+P+ +PGSR+YRSGDLAR DG +EFVGR+D QV Sbjct 1903 YYAGDQLARGYWKRPALTATRFVANPYGGDPGSRLYRSGDLARWTEDGQLEFVGRSDHQV 1962 Query 826 KIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLD 885 ++RGFR+EL +V AA+A V A ++ G SL GYV P D Sbjct 1963 QVRGFRVELAEVEAALAAADGVAAAAARTWEV-HGGTSLAGYVVPQRPIVDDVDKAAFAG 2021 Query 886 RIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRL 945 +RA +A LP YM+P++ VLD +P T GK++R LP P +++ +T TER L Sbjct 2022 EVRAAIATTLPGYMMPSSLTVLDVLPKTESGKLNRPGLPLPAVSTGGLTEPARTDTERAL 2081 Query 946 AQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAG 1005 A++F ELL VG D FF LGG S+L+ +L + R A G+ V R IFE TV LA Sbjct 2082 AKVFAELLSTPEVGRFDDFFALGGDSILSVQLASRAR-AVGLAVSPRMIFENPTVQQLAA 2140 Query 1006 HIDTL 1010 +D L Sbjct 2141 AVDAL 2145 Score = 110 bits (276), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 61/113 (54%), Positives = 81/113 (72%), Gaps = 6/113 (5%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EPA T+TERALA + A++L EVGR+DDFF LGGDSIL+ Q+A+RAR G+ ++ RM+F Sbjct 2071 EPARTDTERALAKVFAELLSTPEVGRFDDFFALGGDSILSVQLASRARAVGLAVSPRMIF 2130 Query 1632 EHPVLCELAAAVDA--KPHVEAEPDDK----HHAPMSTSGLSPDELSALTASW 1678 E+P + +LAAAVDA +AE DD+ PMSTSGLS +L+A+T W Sbjct 2131 ENPTVQQLAAAVDALGDGQADAERDDQAADVRFEPMSTSGLSSTDLAAVTQLW 2183 Score = 103 bits (257), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 104/355 (30%), Positives = 149/355 (42%), Gaps = 43/355 (12%) Query 1024 HDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRT 1083 +D P R+S+ Q R WF D +A+ NI + L G D A+ V ARH +L T Sbjct 40 YDEP-RMSAGQHRMWFVQSVDPDSALLNICVSYRLIGAVDAARLHRAVDAVAARHPVLHT 98 Query 1084 VYREIG-GVPHQIIQ----PPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETDWPIR 1136 Y G G P +++ P A LR ++ +R + FDL D P+R Sbjct 99 TYDTDGEGDPRPVVRDDLHPEWSEHDLSGLADQARRLRLDVLAQRDFRRPFDLSKDSPLR 158 Query 1137 AALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYS 1195 + ++ ++ + HHIA D S F DL AY P +A Sbjct 159 VTVAHLGGDELIMLITAHHIAWDDGSWAPFFADLTRAYTD------------PDGFAAAP 206 Query 1196 VWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV---EFR--- 1249 D A I DYW L D P P L G +V +R Sbjct 207 ALPDLATDPTA-IRQADLDYW----------RPLMADLPEPLELPGPNGSVVPTTWRAQR 255 Query 1250 ----LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 L A + D+ AA++R+ G T +M+L A ++H+ D APV R D Sbjct 256 ATAPLSADVVDRAAALARETGATPYMVLMAVFGALVHRYTQSTDFLFAAPVLNRGVGTED 315 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 +IG++ N VV+R R + T RE+L +TR A+ A+AH D +V NP R Sbjct 316 -VIGYYGNTVVVRLRPRPHQTFRELLAQTRDGAVGAFAHSRADLDWLVRESNPDR 369 Score = 90.5 bits (223), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 42/74 (57%), Positives = 52/74 (71%), Gaps = 0/74 (0%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 A+ YLLDD L+PVPVGVVG++YY G RP+ TATRFVA+P+ PGSRLYR+G Sbjct 1882 AQAYLLDDGLRPVPVGVVGELYYAGDQLARGYWKRPALTATRFVANPYGGDPGSRLYRSG 1941 Query 1542 ERGVWKADGQLELL 1555 + W DGQLE + Sbjct 1942 DLARWTEDGQLEFV 1955 Score = 70.1 bits (170), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 35/73 (48%), Positives = 47/73 (65%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +VYLLD+AL+PVP GV+G++Y G RP TA RFVADPF PG R+YR+G+ Sbjct 801 QVYLLDNALRPVPAGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFT--PGGRMYRSGD 858 Query 1543 RGVWKADGQLELL 1555 A+G +E + Sbjct 859 LARRNANGDIEFV 871 Score = 38.9 bits (89), Expect = 8.4, Method: Compositional matrix adjust. Identities = 26/70 (38%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TE +A + + +L VG D FF+LGG S++AT++ R + G+ L R VFE Sbjct 989 TPTEIRVAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVELGIRDVFELA 1048 Query 1635 VLCELAAAVD 1644 + LA +D Sbjct 1049 TVGLLAERID 1058 >gi|289570524|ref|ZP_06450751.1| predicted protein [Mycobacterium tuberculosis T17] gi|289544278|gb|EFD47926.1| predicted protein [Mycobacterium tuberculosis T17] Length=1023 Score = 1797 bits (4655), Expect = 0.0, Method: Compositional matrix adjust. Identities = 906/950 (96%), Positives = 914/950 (97%), Gaps = 1/950 (0%) Query 439 KTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDK 498 K VDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDK Sbjct 22 KPFVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDK 81 Query 499 SPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTD 558 SPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTD Sbjct 82 SPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTD 141 Query 559 ADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP 618 ADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP Sbjct 142 ADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP 201 Query 619 SFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPG 678 SFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPG Sbjct 202 SFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPG 261 Query 679 VSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIV 738 VSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIV Sbjct 262 VSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIV 321 Query 739 PIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGS 798 PIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGS Sbjct 322 PIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGS 381 Query 799 RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLP 858 RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLP Sbjct 382 RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLP 441 Query 859 RLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKI 918 RLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKI Sbjct 442 RLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKI 501 Query 919 DRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLV 978 DRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLV Sbjct 502 DRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLV 561 Query 979 AAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSW 1038 AAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSW Sbjct 562 AAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSW 621 Query 1039 FNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP 1098 FNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP Sbjct 622 FNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP 681 Query 1099 PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGD 1158 PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGD Sbjct 682 PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGD 741 Query 1159 HWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIR 1218 HWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIR Sbjct 742 HWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIR 801 Query 1219 QLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVA 1278 QLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVA Sbjct 802 QLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVA 861 Query 1279 VVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMA 1338 VVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRT + Sbjct 862 VVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTSRWR 921 Query 1339 LAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGP 1388 + + P ++ +PLFDIVVHV + + GP Sbjct 922 WQRMHIRTCRSTRWWRRSPPAVAVP-HPLFDIVVHVANKCRKTTSSTPGP 970 Score = 83.6 bits (205), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 93/315 (30%), Positives = 134/315 (43%), Gaps = 41/315 (13%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PVGD--DGVAQ 58 WF D A+ NI + + G D A+ V RH ILRT Y +G + Q Sbjct 621 WFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQ 680 Query 59 PTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 P +R A LR E+ +R + F+L D P+R ++ T ++ Sbjct 681 PPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAALLSTP-EQT 729 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRA 178 VL LV HHIA D S V FTDL AY G RPS A P AD + W++ Sbjct 730 VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQYADYSVWQS 782 Query 179 IMADPPEPL----------ELPGPAGTC--VPTSWRAARAT-------LRLPADTAARVA 219 + D + +L G AG P R A + RL A ++A Sbjct 783 ALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLA 842 Query 220 TMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRL 278 ++++ G T +M+L AA ++H+ D + APV R A + IG+F N V +R Sbjct 843 AVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRN 902 Query 279 RPQSAMSFRELLTAT 293 + + RE+L T Sbjct 903 DLRGNPTLREVLQRT 917 Score = 68.9 bits (167), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 35/76 (47%), Positives = 48/76 (64%), Gaps = 2/76 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 ++LLDD+L+PVP GV+G++Y GG R TA RFVADPF PGSR+YR+G+ Sbjct 332 MHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDL 389 Query 1544 GVWKADGQLELLAEIE 1559 ADG +E + + Sbjct 390 ARRNADGDIEFVGRAD 405 Score = 51.2 bits (121), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/96 (37%), Positives = 49/96 (52%), Gaps = 8/96 (8%) Query 1566 AAPVPAEPADTE-------TERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 1618 A P P +DTE TER LA + ++L VG D FF+LGG S+LAT++ A Sbjct 505 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAV 564 Query 1619 RDG-GIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 1653 R+ G+ + R +FE + LA +D A P Sbjct 565 RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 600 >gi|333990182|ref|YP_004522796.1| non-ribosomal peptide synthetase MbtE [Mycobacterium sp. JDM601] gi|333486150|gb|AEF35542.1| non-ribosomal peptide synthetase MbtE [Mycobacterium sp. JDM601] Length=2175 Score = 1733 bits (4488), Expect = 0.0, Method: Compositional matrix adjust. Identities = 908/1503 (61%), Positives = 1102/1503 (74%), Gaps = 29/1503 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP G + NI VSYR++G +D RLR A+ AVA RH +LRTTY V D+G +P Sbjct 49 MWFVQALDPDGTVANISVSYRLSGRLDSDRLRTALAAVADRHPLLRTTYRVDDNGEPRPV 108 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + A + P T++DLT+L+ +A+ LRLEVLAQREF PF L D+PLR+TV+R DEH+L Sbjct 109 LAA-VTPACTEHDLTELAGQARALRLEVLAQREFATPFRLESDSPLRLTVIRLGPDEHIL 167 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTE-ADLNYWRAI 179 LLVAHHIAWDD W VFF DLT AY+ D A P P ++ P + ADL+YWR + Sbjct 168 LLVAHHIAWDDACWPVFFADLTAAYTDPDAFAARPPA--PVVSTPPVSDHGADLDYWRTL 225 Query 180 MADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGA 239 +A+PP+PLELPGP G+ VP + RA T LPA+ + +A++ G TPYMV+ AA A Sbjct 226 LAEPPDPLELPGPRGSAVPHTLRAGLCTRPLPAELMDGITDLARDNGATPYMVVAAALSA 285 Query 240 LVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASG 299 L++RYT +DDFL+A+PVLNR AGTE+ IGYFGNTV +R R ++ F +LLT TRD A G Sbjct 286 LIYRYTGTDDFLIASPVLNRTAGTEETIGYFGNTVVLRARVSASDRFSDLLTRTRDTALG 345 Query 300 AFAHQRINLDRVVRELNPDRRHGA-ERMTRVSFGFREPDGGGFNPPGIECERYDLRSNIT 358 AFAHQ INLDRVVRELNPDRRHG ER+TR+SFGFR G GF+P GI C R D R I Sbjct 346 AFAHQGINLDRVVRELNPDRRHGGVERLTRLSFGFRSGGGDGFHPDGITCVRADYRGKIA 405 Query 359 QLPLGFMVEFDRA---GVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 QLPLG MVE + G L+EAE+L ++L+ AL Q+LRH LL A+A P +S L Sbjct 406 QLPLGIMVEAGGSHDGGALIEAEYLHDVLDEALVDQLLRHLVQLLGAAVAQPQAAVSELD 465 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 ++ + D L SRG F TL LV ++ TPDA AVV + +TY ++N +N Sbjct 466 MLGDDDRRWLEAASRGPDFSATPTTLGALVADRAALTPDAIAVVDDHGRYTYAEINARAN 525 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ H LI GIG+ED+VAVL +S DL+VTALG+ K+GA YVPVDP YP DR++FIL D Sbjct 526 RIAHHLIAAGIGTEDKVAVLFGRSVDLVVTALGIAKAGAAYVPVDPEYPPDRIEFILGDA 585 Query 536 DAKLVLRTPV--RELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPV 593 A LV+R P+ LA DPTDADR+RPLRPDN AYLIYTSG+TGLPKGV V H P+ Sbjct 586 RAALVMREPLPPEALADRPDTDPTDADRVRPLRPDNLAYLIYTSGSTGLPKGVEVSHVPI 645 Query 594 AEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA 653 EY WF EY +DDTD LLQVASPSFDVSI E+FGTL GAR+VIPRP GL DIGYLT Sbjct 646 TEYLTWFGDEYGIDDTDVLLQVASPSFDVSIGELFGTLGNGARLVIPRPDGLRDIGYLTD 705 Query 654 LLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHN 713 LL+ EG+TAMHFVPSLLGLFLSLPGV QWRTL+R+PIGGEPLPGE+ADKFHATFDA+LHN Sbjct 706 LLQREGVTAMHFVPSLLGLFLSLPGVKQWRTLRRIPIGGEPLPGELADKFHATFDAMLHN 765 Query 714 FYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTH 773 FYGPTETV+N+SR+KV G QG R+VPIG P INTTM LLDD+LQPVP GVIGEIYIGGTH Sbjct 766 FYGPTETVVNSSRYKVEGAQGNRVVPIGSPNINTTMWLLDDALQPVPVGVIGEIYIGGTH 825 Query 774 VAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIE 833 VA GY R GLTAERFVADP+ PG R+YR+GDLARRN GD+EF+GRAD+QVK+RGFRIE Sbjct 826 VARGYFDRPGLTAERFVADPWTPGGRLYRTGDLARRNVAGDLEFIGRADDQVKVRGFRIE 885 Query 834 LGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAA 893 LG+VA+AI+VDP+VGQ VVVVSDLP LG+SLV Y+TPA G + V++ RIRARVAA Sbjct 886 LGEVASAISVDPSVGQCVVVVSDLPGLGRSLVAYLTPAE--RGADEDTVEIPRIRARVAA 943 Query 894 ALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELL 953 ALPEYM PAAYVV+D+IPITAHGKIDRAALP+PQ +R PQT TE +AQLF +LL Sbjct 944 ALPEYMAPAAYVVVDDIPITAHGKIDRAALPDPQPIESAPYRDPQTDTEHTVAQLFSQLL 1003 Query 954 GRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTL--- 1010 R++VGADDSFFDLGGHSLLATKLVA +R GV++G+R+IFE +TVT LA ID Sbjct 1004 DREQVGADDSFFDLGGHSLLATKLVAEIRARCGVEIGIRDIFEASTVTRLAAAIDRAPAG 1063 Query 1011 DSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAA 1070 ++ RP L VD GP+ +S+SQ+R+WF YR D +NIP A L GPCDT A AA Sbjct 1064 ETGPGRPPLVAVDRTGPLPVSASQLRTWFAYRLDPRATGDNIPLTARLTGPCDTAALTAA 1123 Query 1071 ITDVVARHEILRTVYREIGGVPHQIIQPPAEVPV---RCAAGSDAA---WLRAELNNERG 1124 I DVVARH+ LRT + EI GVPHQII PP V V RC A W L+ +R Sbjct 1124 INDVVARHDSLRTTFCEIDGVPHQIINPPVPVEVAQLRCPESDPEAVERWTGDRLDEQRA 1183 Query 1125 YVFDLETDWPIRAALLSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPS 1183 FDLE DWPIR ALL P ++ VLSLVVHHIA DHWS VLFTDLLTAYR+R+ G PS Sbjct 1184 GAFDLEHDWPIRTALLHLPGDERVLSLVVHHIAADHWSVEVLFTDLLTAYRSRAAGSAPS 1243 Query 1184 WAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAG 1243 W P ++YAD++ WQ LL D +G++ QR YW+ QL GLA +TG RPDFPRPA GAG Sbjct 1244 WPPPVLRYADFAHWQGELLLDESGLIDAQRRYWMEQLAGLADDTGPRPDFPRPATADGAG 1303 Query 1244 DAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEAN 1303 D+V F + +R LAA++RD G TEFM++QAAVAV+LH AG G D+P+G PVAGR++ Sbjct 1304 DSVAFTVTPEVRAGLAALARDTGATEFMVVQAAVAVLLHLAGSGDDIPLGVPVAGRTDNA 1363 Query 1304 LDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLS 1363 LD L+GFF+NIVVLRN L GNPTLR+V+ R R++AL AYA+ DLPFD++VEA+NP R+LS Sbjct 1364 LDNLVGFFVNIVVLRNRLDGNPTLRDVVLRAREVALGAYANTDLPFDRLVEALNPVRTLS 1423 Query 1364 RNPLFDIVVHVREQMPQDHVIDTGPDG----DTTLRVLEPTFDAAQADLSVNFFAC---G 1416 RNPLF +VVHVR+ H+I++G G D R + PTFD A ADLSVN FA G Sbjct 1424 RNPLFQVVVHVRDAAEVTHLINSGDSGDGEDDLVFRTVMPTFDIAHADLSVNLFATTANG 1483 Query 1417 DEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Y G +IYRT+LYER+T QR ADWL RV+ A A P++ LR++ ++ + R RIL+R + Sbjct 1484 AGYDGRLIYRTDLYERSTVQRLADWLGRVLAAMAGAPERRLRDIGLIDDEQRDRILNRWS 1543 Query 1477 AGA 1479 GA Sbjct 1544 KGA 1546 Score = 406 bits (1043), Expect = 2e-110, Method: Compositional matrix adjust. Identities = 350/1069 (33%), Positives = 512/1069 (48%), Gaps = 105/1069 (9%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTV 61 WF DP NI ++ R+TG D A L A+N V RH LRTT+ DGV + Sbjct 1091 WFAYRLDPRATGDNIPLTARLTGPCDTAALTAAINDVVARHDSLRTTF-CEIDGVPHQII 1149 Query 62 HADLRPGWTQYDLTDLSQRA-QRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + + Q + A +R + L ++ A F+L D P+R ++ DE VL Sbjct 1150 NPPVPVEVAQLRCPESDPEAVERWTGDRLDEQRAGA-FDLEHDWPIRTALLHLPGDERVL 1208 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAY-SRADLGADLGPEHRPSAASGPD------------ 167 LV HHIA D S V FTDL AY SRA A P P D Sbjct 1209 SLVVHHIAADHWSVEVLFTDLLTAYRSRA---AGSAPSWPPPVLRYADFAHWQGELLLDE 1265 Query 168 --TTEADLNYWRAIMA----------DPPEPLELPGPAGTCVPTSWRAARATLRLPADTA 215 +A YW +A D P P G + T RA L Sbjct 1266 SGLIDAQRRYWMEQLAGLADDTGPRPDFPRPATADGAGDSVAFTVTPEVRAGL------- 1318 Query 216 ARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTV 274 A +A++TG T +MV+ AA L+H DD + PV R D +G+F N V Sbjct 1319 ---AALARDTGATEFMVVQAAVAVLLHLAGSGDDIPLGVPVAGRTDNALDNLVGFFVNIV 1375 Query 275 AMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFR 334 +R R + R+++ R++A GA+A+ + DR+V LNP R + +V R Sbjct 1376 VLRNRLDGNPTLRDVVLRAREVALGAYANTDLPFDRLVEALNPVRTLSRNPLFQVVVHVR 1435 Query 335 EP-----------DGGGFNP-------PGIECERYDLRSNITQLPLGFMVEFDRAGVLVE 376 + G G + P + DL N+ F + AG Sbjct 1436 DAAEVTHLINSGDSGDGEDDLVFRTVMPTFDIAHADLSVNL------FATTANGAGYDGR 1489 Query 377 AEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAAR-LREVSRGERF- 434 + ++ E + +++ G +L AP+ L + L+D+ R L S+G Sbjct 1490 LIYRTDLYERSTVQRLADWLGRVLAAMAGAPERRLRDIGLIDDEQRDRILNRWSKGAPIG 1549 Query 435 DTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAV 494 D +T+ +++ +R+ D AV G +Y DL+ S+RL LIE G+ V + Sbjct 1550 DGDPQTIAEVL--APSRSFDGVAVRCAGAELSYPDLHRRSDRLAGLLIEAGVQPGTLVGL 1607 Query 495 LLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRS- 553 + + DL V +G++K+GA Y P+D YP+ RL F++ D + V + + R+ Sbjct 1608 SVRRDLDLAVALVGIMKAGAGYFPLDSGYPRQRLQFMVDDVFSDPVAPKVIVVSSTTRAA 1667 Query 554 --DDPT-----DADRIRPL------------RPDNTAYLIYTSGTTGLPKGVAVPHRPVA 594 D PT DAD L P++ YL++TSG+TG+PKGV HR ++ Sbjct 1668 MPDGPTLLCLDDADVQDQLAKDPPATNLPVPHPEDPMYLVFTSGSTGVPKGVLGTHRSMS 1727 Query 595 EYFVWFKGEYDVDDTDRL-LQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA 653 W Y V D + L +S +F E+ LA GA M++ D L Sbjct 1728 ARLNWQLAHYPVHGGDDIRLAQSSMTFLEGGMELLAGLAAGATMILADDNEFRDPEALAR 1787 Query 654 LLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDA---L 710 L+ E + + V SL+ + ++ R L+R+ GEP+ ++ + A D+ L Sbjct 1788 LITIERVAQVTAVASLISVLVN-SAPDAVRGLRRLVCSGEPVSADLLARLTAVLDSNSQL 1846 Query 711 LHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIG 770 L+NF G TET A R ++ P +GRP + +LLDD+L+PVP GV+GE+Y Sbjct 1847 LNNF-GATETSGAAVRGELTPPTPK----LGRPTPGSQAYLLDDALRPVPPGVVGEVYYA 1901 Query 771 GTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGF 830 G + Y +R GLTA RFVA+PF+PG R+YRSGD AR + DG +EFVGR D QVK+RGF Sbjct 1902 GPQIVQAYWKRPGLTATRFVANPFSPGDRLYRSGDRARWSTDGVLEFVGRTDHQVKVRGF 1961 Query 831 RIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRAR 890 R+EL +V AA+ P V A + R +L GY+ PAA A + +RA Sbjct 1962 RVELAEVEAALRAAPGVATAAARTWE-QRGATTLAGYLVPAAPVADAAPF---VASVRAA 2017 Query 891 VAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFG 950 +AA LP YM+P++ VL+ +P+T GK++R ALP+P +A+ E P TATE+ L + Sbjct 2018 LAAELPGYMVPSSLTVLEAMPLTDSGKLNRPALPQPTVATRGEADPPVTATEKTLVGICA 2077 Query 951 ELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFAT 999 ELLG +R+G D FF+LGG S+L+ +L A R A G+D+ R IFE T Sbjct 2078 ELLGVERIGRSDGFFELGGDSILSVQLAARARAA-GLDIDPRMIFEHPT 2125 Score = 124 bits (310), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 112/352 (32%), Positives = 162/352 (47%), Gaps = 49/352 (13%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-EI 1088 ++ Q R WF D V NI + L G D++ A+ V RH +LRT YR + Sbjct 42 MNDGQRRMWFVQALDPDGTVANISVSYRLSGRLDSDRLRTALAAVADRHPLLRTTYRVDD 101 Query 1089 GGVPHQIIQPPAEVPVRCAA------GSDAAWLRAELNNERGYV--FDLETDWPIRAALL 1140 G P ++ A V C A LR E+ +R + F LE+D P+R ++ Sbjct 102 NGEPRPVL---AAVTPACTEHDLTELAGQARALRLEVLAQREFATPFRLESDSPLRLTVI 158 Query 1141 ST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYR-ARSTGQRPSWAPLPVQYADYSVWQ 1198 P++ +L LV HHIA D V F DL AY + RP P PV V Sbjct 159 RLGPDEHILLLVAHHIAWDDACWPVFFADLTAAYTDPDAFAARP---PAPV------VST 209 Query 1199 SALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGA-GDAVEFRLGAA---- 1253 + D GA + DYW L + P P L G G AV L A Sbjct 210 PPVSDHGADL-----DYWRTLLA----------EPPDPLELPGPRGSAVPHTLRAGLCTR 254 Query 1254 -----IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLI 1308 + D + ++RD G T +M++ AA++ ++++ G D I +PV R+ A ++ I Sbjct 255 PLPAELMDGITDLARDNGATPYMVVAAALSALIYRYTGTDDFLIASPVLNRT-AGTEETI 313 Query 1309 GFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 G+F N VVLR + + ++L RTR AL A+AHQ + D+VV +NP R Sbjct 314 GYFGNTVVLRARVSASDRFSDLLTRTRDTALGAFAHQGINLDRVVRELNPDR 365 Score = 87.4 bits (215), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 44/78 (57%), Positives = 54/78 (70%), Gaps = 2/78 (2%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 ++ YLLDDAL+PVP GVVG+VYY G V A RP TATRFVA+PF+ PG RLYR+G Sbjct 1878 SQAYLLDDALRPVPPGVVGEVYYAGPQIVQAYWKRPGLTATRFVANPFS--PGDRLYRSG 1935 Query 1542 ERGVWKADGQLELLAEIE 1559 +R W DG LE + + Sbjct 1936 DRARWSTDGVLEFVGRTD 1953 Score = 83.2 bits (204), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/115 (51%), Positives = 69/115 (60%), Gaps = 3/115 (2%) Query 1571 AEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMV 1630 A+P T TE+ L I A++L V +GR D FF LGGDSIL+ Q+AARAR G+ + RM+ Sbjct 2061 ADPPVTATEKTLVGICAELLGVERIGRSDGFFELGGDSILSVQLAARARAAGLDIDPRMI 2120 Query 1631 FEHPVLCELAAAVDAKPHVEAEPD---DKHHAPMSTSGLSPDELSALTASWDQWP 1682 FEHP LAAA D D D APMS SGLS D L+ LTASW P Sbjct 2121 FEHPTFAGLAAAADRLAAAGGGTDSAADTAFAPMSVSGLSSDALADLTASWGDSP 2175 Score = 69.3 bits (168), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 36/72 (50%), Positives = 45/72 (63%), Gaps = 2/72 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 ++LLDDAL+PVPVGV+G++Y GG RP TA RFVADP+ PG RLYR G+ Sbjct 801 MWLLDDALQPVPVGVIGEIYIGGTHVARGYFDRPGLTAERFVADPWT--PGGRLYRTGDL 858 Query 1544 GVWKADGQLELL 1555 G LE + Sbjct 859 ARRNVAGDLEFI 870 Score = 55.8 bits (133), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 35/101 (35%), Positives = 55/101 (55%), Gaps = 4/101 (3%) Query 1557 EIERLPTAQAAPVPAEP---ADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQ 1613 +I+R P+ + P T+TE +A + + +L+ +VG D FF+LGG S+LAT+ Sbjct 967 KIDRAALPDPQPIESAPYRDPQTDTEHTVAQLFSQLLDREQVGADDSFFDLGGHSLLATK 1026 Query 1614 VAARAR-DGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 1653 + A R G+ + R +FE + LAAA+D P E P Sbjct 1027 LVAEIRARCGVEIGIRDIFEASTVTRLAAAIDRAPAGETGP 1067 >gi|289443902|ref|ZP_06433646.1| LOW QUALITY PROTEIN: peptide synthetase mbtE [Mycobacterium tuberculosis T46] gi|289416821|gb|EFD14061.1| LOW QUALITY PROTEIN: peptide synthetase mbtE [Mycobacterium tuberculosis T46] Length=859 Score = 1702 bits (4407), Expect = 0.0, Method: Compositional matrix adjust. Identities = 852/852 (100%), Positives = 852/852 (100%), Gaps = 0/852 (0%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT Sbjct 8 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 67 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL Sbjct 68 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 127 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM Sbjct 128 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 187 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL Sbjct 188 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 247 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA Sbjct 248 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 307 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL Sbjct 308 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 367 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER Sbjct 368 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 427 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW Sbjct 428 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 487 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV Sbjct 488 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 547 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF Sbjct 548 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 607 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI Sbjct 608 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 667 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET Sbjct 668 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 727 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR Sbjct 728 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 787 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA Sbjct 788 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 847 Query 841 IAVDPTVGQAVV 852 IAVDPTVGQAVV Sbjct 848 IAVDPTVGQAVV 859 Score = 112 bits (280), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 105/349 (31%), Positives = 150/349 (43%), Gaps = 41/349 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIG 1089 LS Q R WF D A+ NI + + G D A+ V RH ILRT Y +G Sbjct 1 LSDGQARMWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PVG 59 Query 1090 GVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAAL 1139 + QP +R A LR E+ +R + F+L D P+R + Sbjct 60 D--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITV 117 Query 1140 LSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQY 1191 + T ++ VL LV HHIA D S V FTDL AY G RPS A P Sbjct 118 VRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTE 177 Query 1192 ADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 AD + W++ + D + + G T R RL Sbjct 178 ADLNYWRAIMADPPEPLE-------LPGPAGTCVPTSWR------------AARATLRLP 218 Query 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 A ++A ++++ G T +M+L AA ++H+ D + APV R A + IG+F Sbjct 219 ADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYF 277 Query 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 N V +R + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 278 GNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 326 Score = 70.1 bits (170), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 35/72 (49%), Positives = 47/72 (66%), Gaps = 2/72 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 ++LLDD+L+PVP GV+G++Y GG R TA RFVADPF PGSR+YR+G+ Sbjct 756 MHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF--NPGSRMYRSGDL 813 Query 1544 GVWKADGQLELL 1555 ADG +E + Sbjct 814 ARRNADGDIEFV 825 >gi|336458167|gb|EGO37150.1| amino acid adenylation enzyme/thioester reductase family protein [Mycobacterium avium subsp. paratuberculosis S397] Length=1545 Score = 1595 bits (4129), Expect = 0.0, Method: Compositional matrix adjust. Identities = 807/1218 (67%), Positives = 950/1218 (78%), Gaps = 17/1218 (1%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP ALLNICVSYR+TG +D RL AV+AVA RH +L TTY D+G +P Sbjct 49 MWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHTTYDTTDEGDPRPV 108 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + ADLRP W ++DL+ L+++A+RLRL+VLAQR+F PF+LS+D+PLR+T R A +E +L Sbjct 109 LRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLRVTAARLADEELML 168 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+ AHHIAWDDGSW FF DLT+AY+ A D P +A DL+YWR +M Sbjct 169 LITAHHIAWDDGSWAPFFADLTRAYT-APGDFDTTPVVPDLSADPTAIRREDLDYWRPLM 227 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 AD PEPLELPGP G+ VP++WRA RA LPA+ R A +A+ TG TPYMVL+AAF AL Sbjct 228 ADLPEPLELPGPNGSVVPSTWRAQRAFAELPAEIVDRAAALARETGATPYMVLMAAFAAL 287 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DFLVAAPVLNRGA TE+ IGY+GNTV +RLRPQS SFRELL TRD A GA Sbjct 288 VHRYTGSTDFLVAAPVLNRGAATENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGA 347 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 FAH R + D +VRE NPDRRHGA+RMTRVSFG REPDG GF PPG+ CER DLR + QL Sbjct 348 FAHSRTDQDWLVRESNPDRRHGADRMTRVSFGQREPDGAGFCPPGVRCERGDLRGHFNQL 407 Query 361 PLGFMVEFDR-----AGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 PL M+E +R G LVEAE+LVE+L+ L +QMLRH+ LLD+ L+ PD TLS A Sbjct 408 PLSLMIELNRTPDGSGGGLVEAEYLVEVLDQQLVEQMLRHYRTLLDSLLSDPDATLSACA 467 Query 416 LMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASN 475 LM + DA LR VS GE+F TP TL +LV+ + RTPDA AVVYEG +TY D+ E SN Sbjct 468 LMSDADAEWLRAVSTGEQFITPAATLSELVSHRAARTPDAVAVVYEGHTYTYRDIEEESN 527 Query 476 RLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADC 535 R+ HWLIE+G+G+EDRVAVLLDKSP+L++TALGV+K+G VY+PVDP+YPQDRL+FIL D Sbjct 528 RVAHWLIERGVGTEDRVAVLLDKSPELVITALGVLKAGGVYLPVDPTYPQDRLNFILGDA 587 Query 536 DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAE 595 DAKLVLR PV +LA Y + PT+ +RPL P NTAYLIYTSG+TGLPKGV VPH P+AE Sbjct 588 DAKLVLREPVTDLADYPATAPTEL--LRPLTPQNTAYLIYTSGSTGLPKGVPVPHAPIAE 645 Query 596 YFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALL 655 YFVWF EY +D+TDRLLQVASPSFDVSI EIFGTL GAR+VIPRP GL DIGYLT LL Sbjct 646 YFVWFGDEYRIDETDRLLQVASPSFDVSIGEIFGTLIMGARLVIPRPDGLRDIGYLTELL 705 Query 656 RDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFY 715 EGIT+MHFVPSLLGLFLSLPGVSQWRTL+RVPIGGE LPGE+ADKFHATFDA L+NFY Sbjct 706 AREGITSMHFVPSLLGLFLSLPGVSQWRTLRRVPIGGEALPGEIADKFHATFDASLYNFY 765 Query 716 GPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVA 775 GPTETV+N + + V G QGTR+VPIGRPKINT ++LLD++LQPVP GVIGEIYI GTHVA Sbjct 766 GPTETVVNCTSYPVEGAQGTRVVPIGRPKINTRVYLLDNALQPVPPGVIGEIYIAGTHVA 825 Query 776 YGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +GYHRR LTAERFVADPF+ G RMYRSGDLARRNA+GDIEFVGRADEQVKIRGFRIELG Sbjct 826 HGYHRRPQLTAERFVADPFSRGGRMYRSGDLARRNANGDIEFVGRADEQVKIRGFRIELG 885 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++AAAI+VDP+VGQAVV+ DLP+LGKSLVGYVTPA G VD++RIRARVAAAL Sbjct 886 EIAAAISVDPSVGQAVVLAMDLPQLGKSLVGYVTPAQGA---GTETVDVERIRARVAAAL 942 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YM PAAYVVLDEIPITAH KIDRAALP+PQI + TE+R P T TE R+AQLF LLG Sbjct 943 PDYMTPAAYVVLDEIPITAHQKIDRAALPQPQIGAGTEYRDPATPTEHRIAQLFSGLLGH 1002 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDS--- 1012 +RVG DDSFFDLGGHSL+ATKLV A+R GV++G+R++FE ATV LA +D L S Sbjct 1003 ERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELATVGLLAERVDQLSSGEL 1062 Query 1013 DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAIT 1072 RP+L HD P+ LS+SQ+RSWF YR DGP+ VNNIPFAA L GP D +A AA+ Sbjct 1063 TGTRPKLIATAHDEPLPLSASQLRSWFAYRMDGPSPVNNIPFAARLTGPWDIDALIAAVG 1122 Query 1073 DVVARHEILRTVYREIGGVPHQIIQPPA-EVPVRCAAGSDAAWLRAELNNERGYVFDLET 1131 DVVARHEILRT Y E+ GVP+Q++ PP E+PVR G D WL+ +L+ ER + F+L+ Sbjct 1123 DVVARHEILRTRYVELDGVPYQVVGPPGVEIPVRREDGPDDPWLQQQLDAERRHCFELDG 1182 Query 1132 DWPIRAALL--STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + PIR A+L + + VLSLVVHHIA DHWSAGVLF D++TAYRAR G+ PSWAPL V Sbjct 1183 ELPIRVAVLRVANAAEHVLSLVVHHIASDHWSAGVLFADVMTAYRARRGGEAPSWAPLRV 1242 Query 1190 QYADYSVWQSALLDDGAG 1207 QYADY+ WQ L D G Sbjct 1243 QYADYAAWQRTFLGDAGG 1260 Score = 115 bits (288), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 113/356 (32%), Positives = 158/356 (45%), Gaps = 45/356 (12%) Query 1024 HDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRT 1083 HD P R+S Q R WF D +A+ NI + L G DT A+ V ARH +L T Sbjct 37 HDEP-RMSVGQHRMWFVQSVDPDSALLNICVSYRLTGGVDTGRLHRAVDAVAARHPVLHT 95 Query 1084 VYREIG-GVPHQIIQ----PPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETDWPIR 1136 Y G P +++ P A LR ++ +R + FDL D P+R Sbjct 96 TYDTTDEGDPRPVLRADLRPEWAEHDLSGLTEQARRLRLDVLAQRDFRRPFDLSKDSPLR 155 Query 1137 --AALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY 1194 AA L+ E+ +L + HHIA D S F DL AY A P + D Sbjct 156 VTAARLAD-EELMLLITAHHIAWDDGSWAPFFADLTRAYTA------------PGDF-DT 201 Query 1195 SVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV---EFR-- 1249 + L D I DYW L D P P L G +V +R Sbjct 202 TPVVPDLSADPTAIRREDLDYW----------RPLMADLPEPLELPGPNGSVVPSTWRAQ 251 Query 1250 -----LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANL 1304 L A I D+ AA++R+ G T +M+L AA A ++H+ G D + APV R A Sbjct 252 RAFAELPAEIVDRAAALARETGATPYMVLMAAFAALVHRYTGSTDFLVAAPVLNRGAAT- 310 Query 1305 DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 + +IG++ N VV+R + + + RE+L +TR A+ A+AH D +V NP R Sbjct 311 ENVIGYYGNTVVIRLRPQSHQSFRELLAQTRDGAVGAFAHSRTDQDWLVRESNPDR 366 Score = 67.8 bits (164), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 35/75 (47%), Positives = 47/75 (63%), Gaps = 2/75 (2%) Query 1481 TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 RVYLLD+AL+PVP GV+G++Y G RP TA RFVADPF+ G R+YR+ Sbjct 796 NTRVYLLDNALQPVPPGVIGEIYIAGTHVAHGYHRRPQLTAERFVADPFSR--GGRMYRS 853 Query 1541 GERGVWKADGQLELL 1555 G+ A+G +E + Sbjct 854 GDLARRNANGDIEFV 868 Score = 40.4 bits (93), Expect = 3.3, Method: Compositional matrix adjust. Identities = 26/70 (38%), Positives = 39/70 (56%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TE +A + + +L VG D FF+LGG S++AT++ R + G+ + R VFE Sbjct 986 TPTEHRIAQLFSGLLGHERVGVDDSFFDLGGHSLVATKLVTAIRAECGVEIGIRDVFELA 1045 Query 1635 VLCELAAAVD 1644 + LA VD Sbjct 1046 TVGLLAERVD 1055 >gi|289443901|ref|ZP_06433645.1| predicted protein [Mycobacterium tuberculosis T46] gi|289416820|gb|EFD14060.1| predicted protein [Mycobacterium tuberculosis T46] Length=702 Score = 1388 bits (3592), Expect = 0.0, Method: Compositional matrix adjust. Identities = 701/702 (99%), Positives = 702/702 (100%), Gaps = 0/702 (0%) Query 981 VRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFN 1040 +RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFN Sbjct 1 MRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFN 60 Query 1041 YRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPA 1100 YRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPA Sbjct 61 YRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPA 120 Query 1101 EVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHW 1160 EVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHW Sbjct 121 EVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHW 180 Query 1161 SAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQL 1220 SAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQL Sbjct 181 SAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQL 240 Query 1221 GGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVV 1280 GGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVV Sbjct 241 GGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVV 300 Query 1281 LHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALA 1340 LHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALA Sbjct 301 LHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALA 360 Query 1341 AYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPT 1400 AYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPT Sbjct 361 AYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPT 420 Query 1401 FDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREV 1460 FDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREV Sbjct 421 FDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREV 480 Query 1461 EMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSET 1520 EMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSET Sbjct 481 EMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSET 540 Query 1521 ATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETER 1580 ATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETER Sbjct 541 ATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETER 600 Query 1581 ALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELA 1640 ALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELA Sbjct 601 ALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELA 660 Query 1641 AAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQWP 1682 AAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQWP Sbjct 661 AAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQWP 702 Score = 107 bits (268), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 105/341 (31%), Positives = 151/341 (45%), Gaps = 41/341 (12%) Query 2 WFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTY-PVGD--DGVAQ 58 WF D A+ NI + + G D A+ V RH ILRT Y +G + Q Sbjct 58 WFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQ 117 Query 59 PTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 P +R A LR E+ +R + F+L D P+R ++ T ++ Sbjct 118 PPAEVPVR--------CAAGSDAAWLRAELNNERGYV--FDLETDWPIRAALLSTP-EQT 166 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRA 178 VL LV HHIA D S V FTDL AY G RPS A P AD + W++ Sbjct 167 VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG------QRPSWAPLP-VQYADYSVWQS 219 Query 179 IMADPPEPL----------ELPGPAGTC--VPTSWRAARAT-------LRLPADTAARVA 219 + D + +L G AG P R A + RL A ++A Sbjct 220 ALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLA 279 Query 220 TMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRL 278 ++++ G T +M+L AA ++H+ D + APV R A + IG+F N V +R Sbjct 280 AVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRN 339 Query 279 RPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDR 319 + + RE+L TR +A A+AHQ + D+VV +NP R Sbjct 340 DLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 380 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/96 (37%), Positives = 49/96 (52%), Gaps = 8/96 (8%) Query 922 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAV 981 A P P +DTE TER LA + ++L VG D FF+LGG S+LAT++ A Sbjct 586 AAPVPAEPADTE-------TERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 638 Query 982 RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 1017 R+ G+ + R +FE + LA +D A P Sbjct 639 RDG-GIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 673 Score = 49.3 bits (116), Expect = 0.007, Method: Compositional matrix adjust. Identities = 35/72 (49%), Positives = 47/72 (66%), Gaps = 2/72 (2%) Query 749 MHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN--PGSRMYRSGDL 806 ++LLDD+L+PVP GV+G++Y GG R TA RFVADPF PGSR+YR+G+ Sbjct 504 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 563 Query 807 ARRNADGDIEFV 818 ADG +E + Sbjct 564 GVWKADGQLELL 575 >gi|226361741|ref|YP_002779519.1| non-ribosomal peptide synthetase [Rhodococcus opacus B4] gi|226240226|dbj|BAH50574.1| non-ribosomal peptide synthetase [Rhodococcus opacus B4] Length=2218 Score = 1328 bits (3436), Expect = 0.0, Method: Compositional matrix adjust. Identities = 756/1504 (51%), Positives = 960/1504 (64%), Gaps = 35/1504 (2%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFV DP+ A LNI V + G +D RL +V V RH +LRTTY DG Sbjct 91 MWFVHDLDPTHAALNIGVGVELEGALDTDRLFRSVQTVTARHDLLRTTYHTDADGTPFQV 150 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V P WT +D++ L+ + ++ LA EF PF+L+ D PLR TV+RTA + HVL Sbjct 151 VAERGTPAWTVHDVSGLAVGERDEQIGRLAAEEFARPFDLTTDPPLRTTVIRTAPNRHVL 210 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAY-SRADLGA-----DLGPEHRPSAASGPDTTEAD-- 172 LLVAHHIAWDD SW +FF DL +AY S A + A D PDT++AD Sbjct 211 LLVAHHIAWDDDSWGLFFADLGEAYESTAPVDALRIRDDTAQYLDVEVLDRPDTSDADRE 270 Query 173 -LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATL--RLPADTAARVATMAKNTGCTP 229 + YWR++ A PPE LELPG G P++ A A L R+P + A RV +A TG TP Sbjct 271 DVAYWRSVYAQPPEALELPGEHGR--PSAVPAVSAALGGRVPDEVAERVRALAHKTGATP 328 Query 230 YMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFREL 289 +MVLLAAF A+VHRYT S D L A PV+NR A A+GYFGNTV +R R SFR L Sbjct 329 FMVLLAAFVAVVHRYTGSADLLTATPVVNRPAAAGRALGYFGNTVVLRNRVDPRGSFRSL 388 Query 290 LTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECE 349 + TRD+A GAF HQ LDRVVRE+NP R G + + R+ FG R G GF PPGI C Sbjct 389 VEHTRDVAVGAFTHQGAGLDRVVREVNPGRGGGLDALPRLGFGVRSGIGTGFRPPGITCA 448 Query 350 RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDN 409 R DL + Q+PLG M EFD G+ +E E+ E+L+ LA Q+LRHF L A PD Sbjct 449 RTDLHGAVAQVPLGVMAEFDD-GITLELEYQTEVLDENLAAQLLRHFVQFLSAASEEPDR 507 Query 410 TLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHD 469 + + L+ D AR+ + SRG R +TL DLV + TPDA A+V + +Y + Sbjct 508 PIDVIDLLGA-DRARVSDWSRGARAPAATRTLPDLVQARIAETPDAVALVLDDLRISYAE 566 Query 470 LNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLD 529 L +NRL HWLI Q IG ED VA+ +S +++V AL VV++GA Y+P+DP+YP DR++ Sbjct 567 LGARANRLAHWLIAQSIGPEDLVALPFGRSVEMVVAALAVVQTGAAYLPIDPTYPADRIE 626 Query 530 FILADC---DAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGV 586 ++L D L + + PTDADR+RPLR N AY+IYTSG+TGLPKGV Sbjct 627 YLLTDARPTSTLDDLDAAEAAAQDFPATPPTDADRVRPLRTANLAYVIYTSGSTGLPKGV 686 Query 587 AVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLT 646 A+ H + E+F W + EY D LLQVAS SFDVS+ EIFGTL GAR+VIP+P GLT Sbjct 687 AISHAAIVEHFEWMEREYVAYSDDALLQVASTSFDVSVGEIFGTLFGGARLVIPKPDGLT 746 Query 647 DIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHAT 706 DI YLT LLR E +TAMHFVPSLLGLFL LPG +W +L+RVPIGGE LPGE+ADKF AT Sbjct 747 DIPYLTTLLRTEHVTAMHFVPSLLGLFLMLPGAEEWTSLRRVPIGGEALPGELADKFTAT 806 Query 707 FDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 FDA+LHNFYGPTET + A+RFKV G QGTR VPIG PK NT +++LD L VP GV+GE Sbjct 807 FDAMLHNFYGPTETTLAATRFKVEGAQGTRTVPIGTPKANTEVYVLDPVLGLVPPGVVGE 866 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVK 826 +YIGG+ +A GY R LTAERFVADP P R+YR+GDLAR N+DGD+EFVGRAD+QVK Sbjct 867 VYIGGSQLARGYLGRPALTAERFVADPHTPCGRLYRTGDLARWNSDGDLEFVGRADDQVK 926 Query 827 IRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDR 886 IRG+RIELG+V AA+ P V AVV+ + GKSL YV AA D +D Sbjct 927 IRGYRIELGEVEAAVTAHPAVAAAVVIAHESEAAGKSLAAYVV-AASPD-----ALDTAD 980 Query 887 IRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLA 946 +RARVA ALPE+M+PA V+ EIPITA+GK+DR ALP P+ + R P T TE RL Sbjct 981 VRARVADALPEHMVPATVTVVREIPITANGKLDRGALPAPEPQAPAPSREPSTPTEARLC 1040 Query 947 QLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH 1006 +F + LGRDRVG D+SFFDLGGHSLLAT+LV+ +R FG DV +R+ FE TV LA Sbjct 1041 AIFADALGRDRVGVDESFFDLGGHSLLATRLVSRLRAEFGADVSIRDAFEVPTVAGLAAL 1100 Query 1007 IDTLDS---DSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCD 1063 +D S RP L R + + LS +Q+R WF YR +GPN +IPFAA + GP D Sbjct 1101 VDARGEAAGASPRPGLRRAERPPRIPLSYAQLRLWFLYRLEGPNPTYDIPFAARIDGPLD 1160 Query 1064 TNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRC----AAGSDAAWLRAEL 1119 A A AI DVVARHEILRT Y + G P+Q++ P+ + V A G + L AEL Sbjct 1161 AGALAEAIGDVVARHEILRTTYPDHEGKPYQLVHDPSPIDVPLVDLGAHGDRESRLAAEL 1220 Query 1120 NNERGYVFDLETDWPIRAALLS-TPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARST 1178 + F LE++ PIRA +L P + V+SLV+HHIAGD WSA +LF DL AY AR Sbjct 1221 AEAAAHSFVLESELPIRARILRLAPGEHVVSLVIHHIAGDEWSAPILFGDLAVAYAARLG 1280 Query 1179 GQRPSWAPLPVQYADYSVWQSALLDDGAG---IVGPQRDYWIRQLGGLAGETGLRPDFPR 1235 G P+W LP+QYADY++WQ +LDD + G Q YW L L +T + D PR Sbjct 1281 GTAPAWPELPLQYADYALWQREMLDDDTSTDTVGGRQIAYWRSVLADLPEDTTVLRDRPR 1340 Query 1236 PALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAP 1295 P + S GD V F + + L ++R G +EFM+LQ AVAV+L K G G D+P+G P Sbjct 1341 PPIASSRGDTVTFAVPDRVHAGLTELARTCGASEFMILQTAVAVLLAKLGAGEDIPLGTP 1400 Query 1296 VAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEA 1355 VAGR+E +L +++GFF+N +VLRNDL GNPTLR + R R+ AL A++HQDLPF+++V+ Sbjct 1401 VAGRAEHDLREIVGFFVNTLVLRNDLSGNPTLRTAVLRARETALGAFSHQDLPFERLVDV 1460 Query 1356 VNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFAC 1415 + P RSLSR+PLF ++VH+RE V G D L + P A+ DL+V+F Sbjct 1461 LGPDRSLSRHPLFQVLVHLRESGAHSEVRAVGVGRDVRLTTIVPESGTAKFDLTVDFHVT 1520 Query 1416 GDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRS 1475 E RG + YRT+LY+R T +R A WL RV+ FAD PD+ LR+V++ + R R+L S Sbjct 1521 DGELRGGLNYRTDLYDRRTVERLATWLGRVLAEFADHPDRHLRDVDVSAPADRERLLGWS 1580 Query 1476 NAGA 1479 A Sbjct 1581 RGDA 1584 Score = 390 bits (1003), Expect = 8e-106, Method: Compositional matrix adjust. Identities = 347/1067 (33%), Positives = 491/1067 (47%), Gaps = 81/1067 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + +I + RI G +D L +A+ V RH ILRTTYP +G Sbjct 1134 LWFLYRLEGPNPTYDIPFAARIDGPLDAGALAEAIGDVVARHEILRTTYP-DHEGKPYQL 1192 Query 61 VHADLRPGWTQYDLTDLSQRAQR-LRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 VH P L DL R RL F L + P+R ++R A EHV Sbjct 1193 VH---DPSPIDVPLVDLGAHGDRESRLAAELAEAAAHSFVLESELPIRARILRLAPGEHV 1249 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG--ADLGPEHRPSAASGP--------DTT 169 + LV HHIA D+ S + F DL AY+ A LG A PE A D T Sbjct 1250 VSLVIHHIAGDEWSAPILFGDLAVAYA-ARLGGTAPAWPELPLQYADYALWQREMLDDDT 1308 Query 170 EAD------LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D + YWR+++AD PE + S R T +P A + +A+ Sbjct 1309 STDTVGGRQIAYWRSVLADLPEDTTVLRDRPRPPIASSRGDTVTFAVPDRVHAGLTELAR 1368 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQS 282 G + +M+L A L+ + +D + PV R + +G+F NT+ +R Sbjct 1369 TCGASEFMILQTAVAVLLAKLGAGEDIPLGTPVAGRAEHDLREIVGFFVNTLVLRNDLSG 1428 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 + R + R+ A GAF+HQ + +R+V L PDR + +V RE G Sbjct 1429 NPTLRTAVLRARETALGAFSHQDLPFERLVDVLGPDRSLSRHPLFQVLVHLRE-SGAHSE 1487 Query 343 PPGIECERYDLRSNITQLPLGFMVEFD------------RAGVLVEAEHLVEILEPALAK 390 + R D+R T +P +FD R G+ + ++ + + Sbjct 1488 VRAVGVGR-DVRLT-TIVPESGTAKFDLTVDFHVTDGELRGGL----NYRTDLYDRRTVE 1541 Query 391 QMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLV-DLVNEQT 449 ++ G +L PD L + + D RL SRG+ D V +L+ Sbjct 1542 RLATWLGRVLAEFADHPDRHLRDVDVSAPADRERLLGWSRGDAPDPAAPASVPELLEPSR 1601 Query 450 TRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGV 509 PD AV TY L+ S+RL L +G G VA+ + +S D++V + V Sbjct 1602 AFGPDVIAVECGDDTVTYPRLHVLSDRLAALLRRRGAGPGTFVALAVPRSIDMVVALVAV 1661 Query 510 VKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT--------PVRELAGYRSDDPTDADR 561 +KSGA ++P+D YP +RL F++AD V+ T PV + DDP Sbjct 1662 MKSGAAFLPLDLRYPAERLAFMIADAAPVCVVTTGAVGGTLPPVPGVDLLVLDDPATIHD 1721 Query 562 IRPL--------RPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDV------- 606 + + R D AY ++TSG+TG PKGV HR +A W + V Sbjct 1722 LAGVAVETLPFPRGDEAAYFLFTSGSTGRPKGVVGTHRAMANRLAWQPRLFPVHPPADAP 1781 Query 607 DDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFV 666 D D L S SF E+ +A GAR+++ D+ L LL I + V Sbjct 1782 DAGDVRLAQGSLSFLDGGLELLAGIAAGARLILADDAEARDLEALARLLGRHPIGQVTAV 1841 Query 667 PSLLGLFL-SLPGVSQWRTLQRVPIGGEPL-PGEVADKFHATFDALLHNFYGPTETVINA 724 S + + + + P V R + R GEPL P +A D+ + N YG TET + Sbjct 1842 ASAVSVLVDTAPDVV--RRVPRWVCSGEPLTPSLLAALAGTAPDSDIVNAYGTTETAGSI 1899 Query 725 SRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGL 784 R G ++ +GRP + +LDD+L+PVP GV+GEIY+ G +A GY R GL Sbjct 1900 VR----GLMEPGVLRVGRPVPGVRLLVLDDALKPVPQGVVGEIYVAGAQLARGYWNRPGL 1955 Query 785 TAERFVADPF--NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIA 842 TA RFVA P G R+YR+GD N DG + F GR D QVK+RG+RIELG+V A+ Sbjct 1956 TAARFVAHPSPDRAGERLYRTGDRGSWNPDGHLCFAGRTDHQVKVRGYRIELGEVENALR 2015 Query 843 VDPTVGQAVVVVSDLPRLG-KSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLP 901 P G A R G SL GYV P G D G L +RA + LP YMLP Sbjct 2016 SAP--GVATAAARTYGRDGATSLAGYVVPRDTGPD-RDEGQFLAAVRAHLDRTLPGYMLP 2072 Query 902 AAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGAD 961 A L+ +P T GK+DR +LP PQ+A+ F P TATER LA LF E+LG VG Sbjct 2073 ATVTALETMPTTGSGKLDRLSLPVPQVATAGHFEPPVTATERALAALFEEILGVTEVGRS 2132 Query 962 DSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHID 1008 D FF LGG S+++ +L R+A G+ + + +FE++T+ LA D Sbjct 2133 DGFFTLGGDSIVSIQLAGRARSA-GLVLTPQLVFEYSTLAELAEACD 2178 Score = 141 bits (356), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 137/480 (29%), Positives = 208/480 (44%), Gaps = 37/480 (7%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR-EI 1088 LS Q R WF + D +A NI L G DT+ ++ V ARH++LRT Y + Sbjct 84 LSEGQRRMWFVHDLDPTHAALNIGVGVELEGALDTDRLFRSVQTVTARHDLLRTTYHTDA 143 Query 1089 GGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNER---------GYVFDLETDWPIRAAL 1139 G P Q++ AE D + L +E+ FDL TD P+R + Sbjct 144 DGTPFQVV---AERGTPAWTVHDVSGLAVGERDEQIGRLAAEEFARPFDLTTDPPLRTTV 200 Query 1140 LST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQ 1198 + T P + VL LV HHIA D S G+ F DL AY + + QY D V Sbjct 201 IRTAPNRHVLLLVAHHIAWDDDSWGLFFADLGEAYESTAPVDALRIRDDTAQYLDVEVLD 260 Query 1199 SALLDDGAGIVGPQRD---YWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIR 1255 D R+ YW L + RP+ + A+ R+ + Sbjct 261 RPDTSDA------DREDVAYWRSVYAQPPEALELPGEHGRPSAVPAVSAALGGRVPDEVA 314 Query 1256 DKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIV 1315 +++ A++ G T FM+L AA V+H+ G D+ PV R A + +G+F N V Sbjct 315 ERVRALAHKTGATPFMVLLAAFVAVVHRYTGSADLLTATPVVNRPAAA-GRALGYFGNTV 373 Query 1316 VLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVR 1375 VLRN + + R +++ TR +A+ A+ HQ D+VV VNP R + L + VR Sbjct 374 VLRNRVDPRGSFRSLVEHTRDVAVGAFTHQGAGLDRVVREVNPGRGGGLDALPRLGFGVR 433 Query 1376 EQMPQDHVIDTG--PDGDTTLRVLEPTFDAAQADLSVNFFACGDE-YRGHVIYRTELYER 1432 I TG P G T R A A + + A D+ + Y+TE+ + Sbjct 434 SG------IGTGFRPPGITCART---DLHGAVAQVPLGVMAEFDDGITLELEYQTEVLDE 484 Query 1433 ATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALK 1492 A + V+ + A ++ PD+P+ ++++ A R R+ D S A L D ++ Sbjct 485 NLAAQLLRHFVQFLSAASEEPDRPIDVIDLLGAD-RARVSDWSRGARAPAATRTLPDLVQ 543 Score = 97.1 bits (240), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 58/110 (53%), Positives = 71/110 (65%), Gaps = 2/110 (1%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 EP T TERALAA+ ++L V EVGR D FF LGGDSI++ Q+A RAR G+ LT ++VF Sbjct 2106 EPPVTATERALAALFEEILGVTEVGRSDGFFTLGGDSIVSIQLAGRARSAGLVLTPQLVF 2165 Query 1632 EHPVLCELAAAVD--AKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWD 1679 E+ L ELA A D A + APMS SGL PD+L+AL SWD Sbjct 2166 EYSTLAELAEACDRAAAQAEPEPEPAEPSAPMSVSGLDPDQLAALRKSWD 2215 Score = 73.9 bits (180), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 37/70 (53%), Positives = 43/70 (62%), Gaps = 0/70 (0%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R+ +LDDALKPVP GVVG++Y G RP TA RFVA P + G RLYR G+ Sbjct 1919 RLLVLDDALKPVPQGVVGEIYVAGAQLARGYWNRPGLTAARFVAHPSPDRAGERLYRTGD 1978 Query 1543 RGVWKADGQL 1552 RG W DG L Sbjct 1979 RGSWNPDGHL 1988 Score = 67.8 bits (164), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 37/72 (52%), Positives = 43/72 (60%), Gaps = 2/72 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 VY+LD L VP GVVG+VY GG L RP+ TA RFVADP P RLYR G+ Sbjct 849 VYVLDPVLGLVPPGVVGEVYIGGSQLARGYLGRPALTAERFVADPH--TPCGRLYRTGDL 906 Query 1544 GVWKADGQLELL 1555 W +DG LE + Sbjct 907 ARWNSDGDLEFV 918 Score = 52.8 bits (125), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 35/76 (47%), Positives = 47/76 (62%), Gaps = 2/76 (2%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMV 1630 EP+ T TE L AI AD L VG + FF+LGG S+LAT++ +R R + G ++ R Sbjct 1030 EPS-TPTEARLCAIFADALGRDRVGVDESFFDLGGHSLLATRLVSRLRAEFGADVSIRDA 1088 Query 1631 FEHPVLCELAAAVDAK 1646 FE P + LAA VDA+ Sbjct 1089 FEVPTVAGLAALVDAR 1104 >gi|54022733|ref|YP_116975.1| putative non-ribosomal peptide synthetase [Nocardia farcinica IFM 10152] gi|54014241|dbj|BAD55611.1| putative non-ribosomal peptide synthetase [Nocardia farcinica IFM 10152] Length=1701 Score = 1264 bits (3270), Expect = 0.0, Method: Compositional matrix adjust. Identities = 705/1537 (46%), Positives = 943/1537 (62%), Gaps = 63/1537 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+Q D + LNIC++YR+TG +D RLR+A V RH +LRTTY V + G Sbjct 53 MWFLQTRDAADTTLNICLAYRLTGALDEQRLREAFGTVVARHDLLRTTYGVDEQGEPYQV 112 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 D+ W +DLTDL ++ + R+EVLA+REF PF+L+ + PLR T+VRT A+EHVL Sbjct 113 FTDDVVLAWQSHDLTDLPEQGRARRVEVLARREFGRPFDLAAETPLRATLVRTGAEEHVL 172 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDT-TEADLNYWRAI 179 +LV HHIA+DD SW VFF ++ AY+ A+ GA +GPD EAD+ YWRA Sbjct 173 VLVVHHIAFDDESWPVFFAEVNAAYNGAEPGAAPAQFVAAEVLAGPDEPAEADVEYWRAS 232 Query 180 MADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGA 239 + PEPLELPG A + S +A R TL LPAD RV A+ TP+MVLLAAF A Sbjct 233 LRPLPEPLELPGSAPSQ--PSTQAERRTLALPADLMTRVDAFARERSATPFMVLLAAFDA 290 Query 240 LVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASG 299 LVHRYT + DFLV+ PV NR A TE IGYFGNT+ +R + SF L+ ATR+ Sbjct 291 LVHRYTAATDFLVSVPVTNRRAATEGLIGYFGNTLLLRAAVRPHDSFTGLVEATRETCLN 350 Query 300 AFAHQRINLDRVVRELNPDR---RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSN 356 FAHQ + +DRVVRE NP+R R G +++ R+ F R+ F G+ ++ +L + Sbjct 351 GFAHQSVGIDRVVREANPERVAGRDGMDQLVRLGFSVRK-GSDAFALRGVTAQQLELGAP 409 Query 357 ITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLAL 416 Q+PL V + G L+E E+ ++L L +Q+LRH+ LLD+AL P L+ LA+ Sbjct 410 TAQVPLALAVVLESTGALLELEYQTDVLSAELVEQLLRHYLHLLDSALREPTRRLADLAM 469 Query 417 MDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNR 476 + D A + E S GE P T+V L+ + P A+V + TY L+ +NR Sbjct 470 LSPEDRAAVLEQSHGELVPAPATTMVALLERAAAQRPGDLALVSDDTELTYDQLHRRANR 529 Query 477 LGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCD 536 + LI +GIG+ED V + + S + +V L V+KSGA Y+P+DP+YP+DR+++++ D + Sbjct 530 VARLLIAEGIGTEDIVGLRMTTSVEFVVAMLAVLKSGAAYLPIDPAYPEDRIEYLVEDAE 589 Query 537 AKLVLRTPVRELAGYRSDD-----PTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHR 591 LVL A + D PTDADR+RPL P N AY+IYTSG+TG PKGV VPH Sbjct 590 PALVLGPVEFAAAESAAADLPDTAPTDADRVRPLLPGNLAYVIYTSGSTGKPKGVPVPHA 649 Query 592 PVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYL 651 +AE+ F E+ + DRLLQ +S SFD S+ ++F TL+ GAR+++P+P DI Y+ Sbjct 650 AIAEHVESFTAEWGMTAEDRLLQSSSVSFDASLLDLFVTLSLGARLIVPKPDAFRDIAYV 709 Query 652 TALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALL 711 L+ G+T +H VPS+L FL LP VS+WR L+ VP+GGE LPGEVADKF FDA L Sbjct 710 ADLITRRGVTVLHMVPSMLSTFLLLPEVSEWRALRHVPVGGEALPGEVADKFAGVFDAEL 769 Query 712 HNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGG 771 N YGPTE V+ ++ V GPQGT +VPIG P N ++LD++LQ VP GV+GE+Y+GG Sbjct 770 RNHYGPTEAVVCSTHMPVEGPQGTGVVPIGVPNRNVYTYVLDEALQLVPAGVVGELYLGG 829 Query 772 THVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFR 831 +A GY R LTA+RFVADPF PG+R+YR+GDL RRN G++EFVGRADEQVK+RGFR Sbjct 830 DQLARGYLGRPELTAQRFVADPFTPGARLYRTGDLVRRNHFGELEFVGRADEQVKVRGFR 889 Query 832 IELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARV 891 IELG+V AA+A P VG VVVV++ P +G L YV PAA D A +DL+ +RA Sbjct 890 IELGEVEAAVATHPAVGHCVVVVAEDPAVGPMLAAYVVPAA--DEIAGGEIDLEEVRAHA 947 Query 892 AAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGE 951 AA LP+YM+P+A+ V+ EIP+T +GK+D+ ALP P A + FR P TATERRL +FG Sbjct 948 AAVLPQYMVPSAFAVIPEIPLTVNGKLDKRALPAPTPAVERSFREPATATERRLCAIFGH 1007 Query 952 LLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH----- 1006 L +RVGADDSFF+LGGHSLLA +LVA +R FG+++ VR IF+ T LA Sbjct 1008 LFKMERVGADDSFFELGGHSLLAARLVAQIRAEFGIELDVRAIFDTPTAAGLAARLVARF 1067 Query 1007 -------IDTLDSD-------------------------SARPRLTRVDHDGPVRLSSSQ 1034 +D++D+D SARP L + + LS SQ Sbjct 1068 RDEFDIDLDSMDADFDGADTEFVGADIDFVEAEGALPGGSARPPLVAAERPERIPLSYSQ 1127 Query 1035 MRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQ 1094 + WF YR +G N+PFA + G DT A +AA+ D+VARHE LRT + E GVP+Q Sbjct 1128 LAMWFQYRMEGATVAGNLPFAMRIDGDLDTTALSAALNDIVARHEALRTNFPEHDGVPYQ 1187 Query 1095 IIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVH 1153 ++ P E+ + A S+ L A L+ RGY+F +ET+ IR LL P VLSL+VH Sbjct 1188 LVHPSLEIELPVLATSEEN-LDATLDELRGYLFSVETEPLIRPTLLVLGPRTHVLSLLVH 1246 Query 1154 HIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLD-DGAG----I 1208 HI DH S G+ DL+TAYRAR G P WA +QYADY++WQ A D + AG Sbjct 1247 HIVADHASLGIFLDDLITAYRARVAGSAPRWAAPAIQYADYALWQRAAFDHEPAGAPSEF 1306 Query 1209 VGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVT 1268 + ++W L GL E + PD PRP +L G+ V F + AA R L +++ GV+ Sbjct 1307 ARAEIEHWRGVLAGLPDEISVAPDRPRPPVLGKRGEVVTFVVPAAERAALEDLAKQSGVS 1366 Query 1269 EFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLR 1328 EFML QAAVA +LH GGG D+ +G PVA R E + L+G F N+VVLRNDL G+PTLR Sbjct 1367 EFMLYQAAVATLLHTLGGGTDIAVGTPVAARVEPAVGALVGLFANMVVLRNDLAGDPTLR 1426 Query 1329 EVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGP 1388 V+ R+R + L A+AHQ+LP +++VEA+NP RS SRNPLF ++H R Sbjct 1427 TVIARSRDVVLDAHAHQELPIERLVEALNPPRSRSRNPLFQSMIHFRGADWAPAPTALSE 1486 Query 1389 DGDTTLRVLEPTFDAAQADLSVNFFACGD-EYRGHVIYRTELYERATAQRFADWLVRVVE 1447 GDTTL VL FD + DL+++ D V+ +LYE ATA+ AD L + Sbjct 1487 SGDTTLTVLPTDFDISFLDLNLSLNVGVDGSLEVRVVVNADLYEPATARSIADALRATLA 1546 Query 1448 AFADRPDQPLREVEMVSAQARRRIL----DRSNAGAG 1480 AFA PD+ + E+ ++ Q R+L R AGAG Sbjct 1547 AFAADPDRKVSELRVLPPQELERLLAPPAPRDTAGAG 1583 Score = 120 bits (301), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 128/469 (28%), Positives = 200/469 (43%), Gaps = 53/469 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 LS Q R WF D + NI A L G D A VVARH++LRT Y + Sbjct 46 LSPGQRRMWFLQTRDAADTTLNICLAYRLTGALDEQRLREAFGTVVARHDLLRTTYGVDE 105 Query 1089 GGVPHQIIQPPAEVPVRCAAGSD------AAWLRAELNNERGYVFDLETDWPIRAALLST 1142 G P+Q+ + + +D A + E G FDL + P+RA L+ T Sbjct 106 QGEPYQVFTDDVVLAWQSHDLTDLPEQGRARRVEVLARREFGRPFDLAAETPLRATLVRT 165 Query 1143 -PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSAL 1201 E+ VL LVVHHIA D S V F ++ AY G P A P Q+ V Sbjct 166 GAEEHVLVLVVHHIAFDDESWPVFFAEVNAAY----NGAEPGAA--PAQFVAAEV----- 214 Query 1202 LDDGAGIVGPQR------DYWIRQLGGLAGETGLRPDFPRPALLSGAGDA-----VEFR- 1249 + GP +YW LRP P P L G+ + E R Sbjct 215 ------LAGPDEPAEADVEYW---------RASLRP-LPEPLELPGSAPSQPSTQAERRT 258 Query 1250 --LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQL 1307 L A + ++ A +R+ T FM+L AA ++H+ D + PV R A + L Sbjct 259 LALPADLMTRVDAFARERSATPFMVLLAAFDALVHRYTAATDFLVSVPVTNRRAAT-EGL 317 Query 1308 IGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPL 1367 IG+F N ++LR +R + + +++ TR+ L +AHQ + D+VV NP+R R+ + Sbjct 318 IGYFGNTLLLRAAVRPHDSFTGLVEATRETCLNGFAHQSVGIDRVVREANPERVAGRDGM 377 Query 1368 FDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRT 1427 + VR D T + LE AQ L++ + Y+T Sbjct 378 DQL---VRLGFSVRKGSDAFALRGVTAQQLELGAPTAQVPLALAVVLESTGALLELEYQT 434 Query 1428 ELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 ++ ++ + ++++ P + L ++ M+S + R +L++S+ Sbjct 435 DVLSAELVEQLLRHYLHLLDSALREPTRRLADLAMLSPEDRAAVLEQSH 483 Score = 68.2 bits (165), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/136 (45%), Positives = 80/136 (59%), Gaps = 18/136 (13%) Query 1557 EIERLPTAQAAPVPAEPA--------DTETERALAAILADVLEVGEVGRYDDFFNLGGDS 1608 E+ERL A P P + A ETER L +L ++L++ +V D+FF LGGDS Sbjct 1566 ELERL---LAPPAPRDTAGAGAVSGGSAETERTLIQLLEELLDITDVEPEDNFFALGGDS 1622 Query 1609 ILATQVAARARDGGIPLTARMVFEHPVLCELAAA------VDAKPHVEAEPDDKHHAPMS 1662 +++ Q +ARA G+ LT ++VFEH + ELAAA VDA+ A P + APMS Sbjct 1623 VISIQWSARAAALGLALTPQLVFEHMTIAELAAAVDAAGPVDAQAESTAAPQPE-SAPMS 1681 Query 1663 TSGLSPDELSALTASW 1678 SGL D L+ALTASW Sbjct 1682 ASGLDSDALAALTASW 1697 Score = 66.2 bits (160), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 36/71 (51%), Positives = 45/71 (64%), Gaps = 2/71 (2%) Query 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERG 1544 Y+LD+AL+ VP GVVG++Y GG L RP TA RFVADPF PG+RLYR G+ Sbjct 808 YVLDEALQLVPAGVVGELYLGGDQLARGYLGRPELTAQRFVADPFT--PGARLYRTGDLV 865 Query 1545 VWKADGQLELL 1555 G+LE + Sbjct 866 RRNHFGELEFV 876 Score = 52.8 bits (125), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/87 (43%), Positives = 49/87 (57%), Gaps = 8/87 (9%) Query 1567 APVPA------EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR- 1619 AP PA EPA T TER L AI + ++ VG D FF LGG S+LA ++ A+ R Sbjct 981 APTPAVERSFREPA-TATERRLCAIFGHLFKMERVGADDSFFELGGHSLLAARLVAQIRA 1039 Query 1620 DGGIPLTARMVFEHPVLCELAAAVDAK 1646 + GI L R +F+ P LAA + A+ Sbjct 1040 EFGIELDVRAIFDTPTAAGLAARLVAR 1066 >gi|289758502|ref|ZP_06517880.1| peptide synthetase mbtE [Mycobacterium tuberculosis T85] gi|289714066|gb|EFD78078.1| peptide synthetase mbtE [Mycobacterium tuberculosis T85] Length=636 Score = 1219 bits (3155), Expect = 0.0, Method: Compositional matrix adjust. Identities = 621/623 (99%), Positives = 621/623 (99%), Gaps = 0/623 (0%) Query 1060 GPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAEL 1119 G CDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAEL Sbjct 14 GLCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAEL 73 Query 1120 NNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG 1179 NNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG Sbjct 74 NNERGYVFDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTG 133 Query 1180 QRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALL 1239 QRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALL Sbjct 134 QRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALL 193 Query 1240 SGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGR 1299 SGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGR Sbjct 194 SGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGR 253 Query 1300 SEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQ 1359 SEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQ Sbjct 254 SEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQ 313 Query 1360 RSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEY 1419 RSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEY Sbjct 314 RSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEY 373 Query 1420 RGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGA 1479 RGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQ LREVEMVSAQARRRILDRSNAGA Sbjct 374 RGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQRLREVEMVSAQARRRILDRSNAGA 433 Query 1480 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYR 1539 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYR Sbjct 434 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYR 493 Query 1540 NGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYD 1599 NGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYD Sbjct 494 NGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYD 553 Query 1600 DFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHA 1659 DFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHA Sbjct 554 DFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVLCELAAAVDAKPHVEAEPDDKHHA 613 Query 1660 PMSTSGLSPDELSALTASWDQWP 1682 PMSTSGLSPDELSALTASWDQWP Sbjct 614 PMSTSGLSPDELSALTASWDQWP 636 Score = 99.0 bits (245), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 97/309 (32%), Positives = 140/309 (46%), Gaps = 41/309 (13%) Query 34 AVNAVARRHRILRTTY-PVGD--DGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLA 90 A+ V RH ILRT Y +G + QP +R A LR E+ Sbjct 24 AITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVR--------CAAGSDAAWLRAELNN 75 Query 91 QREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADL 150 +R + F+L D P+R ++ T ++ VL LV HHIA D S V FTDL AY Sbjct 76 ERGYV--FDLETDWPIRAALLSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARST 132 Query 151 GADLGPEHRPSAASGPDTTEADLNYWRAIMADPPEPL----------ELPGPAGTC--VP 198 G RPS A P AD + W++ + D + +L G AG P Sbjct 133 G------QRPSWAPLP-VQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRP 185 Query 199 TSWRAARAT-------LRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFL 251 R A + RL A ++A ++++ G T +M+L AA ++H+ D Sbjct 186 DFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVP 245 Query 252 VAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDR 310 + APV R A + IG+F N V +R + + RE+L TR +A A+AHQ + D+ Sbjct 246 IGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQ 305 Query 311 VVRELNPDR 319 VV +NP R Sbjct 306 VVEAVNPQR 314 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/96 (37%), Positives = 49/96 (52%), Gaps = 8/96 (8%) Query 922 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAV 981 A P P +DTE TER LA + ++L VG D FF+LGG S+LAT++ A Sbjct 520 AAPVPAEPADTE-------TERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 572 Query 982 RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARP 1017 R+ G+ + R +FE + LA +D A P Sbjct 573 RDG-GIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 607 Score = 49.3 bits (116), Expect = 0.006, Method: Compositional matrix adjust. Identities = 35/72 (49%), Positives = 47/72 (66%), Gaps = 2/72 (2%) Query 749 MHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN--PGSRMYRSGDL 806 ++LLDD+L+PVP GV+G++Y GG R TA RFVADPF PGSR+YR+G+ Sbjct 438 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 497 Query 807 ARRNADGDIEFV 818 ADG +E + Sbjct 498 GVWKADGQLELL 509 >gi|169629208|ref|YP_001702857.1| putative peptide synthetase MbtE [Mycobacterium abscessus ATCC 19977] gi|169241175|emb|CAM62203.1| Putative peptide synthetase MbtE [Mycobacterium abscessus] Length=1675 Score = 1190 bits (3079), Expect = 0.0, Method: Compositional matrix adjust. Identities = 660/1507 (44%), Positives = 900/1507 (60%), Gaps = 48/1507 (3%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+Q DP+ LNICV++R+ G +D RLRDAV AV RRH +LRT Y V G Sbjct 51 MWFMQTKDPADTSLNICVAHRMRGALDQTRLRDAVAAVIRRHDVLRTVYGVDSAGEPYQL 110 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + WT DLTDL+ AQ ++ LA EF PF+L+ D PLR+T++R A++ V+ Sbjct 111 FVEEFEVPWTAVDLTDLTGDAQDRQVRALADSEFGRPFDLAADRPLRVTLLRLGAEDFVV 170 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 LLV HHI WDD SW VFF +L++ Y + + P+ +A +++ADL YWR + Sbjct 171 LLVVHHICWDDNSWEVFFAELSEYYHGRPVQGE-APQFMVVSADTEPSSDADLTYWRRAL 229 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 P+PLELPG A T +S A R + +PA+TAAR+ A+ TP+MVLLAAFG L Sbjct 230 TPLPDPLELPGAASTY--SSRAARRLAVPMPAETAARIEEFAREHSATPFMVLLAAFGVL 287 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 VHRYT S DF+ A PV R + E AIGYFGNT+ +R SF + A R++ A Sbjct 288 VHRYTGSRDFVTAIPVAERKSNAEKAIGYFGNTLLLRTVVNPDDSFASHVAAVREVCLDA 347 Query 301 FAHQRINLDRVVRELNPDR---RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNI 357 F HQ + +D VVRE+NP R G + + R+ F R+ D G+ G++ + DL + Sbjct 348 FGHQNVGIDEVVREVNPSRSIGHDGMDELVRLGFSMRK-DASGYRLEGVDVTQLDLAAVS 406 Query 358 TQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALM 417 QLPL + + +G +VE E+ ++L L Q+L H+ LL + L+ P+ TL+ L L Sbjct 407 AQLPLSLAIATESSGTIVEFEYQTDVLPQWLVGQLLVHYQRLLADGLSRPEETLARLELF 466 Query 418 DERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRL 477 D + + L + S G TLVDL++ TP+A AVV + TY L + SNR Sbjct 467 DAEEHSALLDQSHGVLTRPSAATLVDLLDAAARATPEALAVVSDDVELTYELLQQRSNRF 526 Query 478 GHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDA 537 WL+ QG G+ED +A+ + S + IV LGV+KSGA Y+P+DP+ P++R+++++AD Sbjct 527 ARWLVAQGAGTEDVIALQMSTSVEFIVAMLGVLKSGAAYMPIDPALPEERIEYLIADAKP 586 Query 538 KLVLRTP---VRELAGYRSDDP--TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRP 592 ++V+R V E A D TDADR+RPL PDN AY+IYTSG+TG PKGVAV H Sbjct 587 RIVMRPQEFRVAEAAATGLGDAPITDADRLRPLLPDNLAYVIYTSGSTGRPKGVAVAHAA 646 Query 593 VAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLT 652 +AE+ V F E+ + DR+LQ S SFD S+A+I L+ GA++VIP+P +DIGY+ Sbjct 647 IAEHVVSFTAEWSMTADDRMLQSTSVSFDASLADILCPLSLGAQLVIPKPNPFSDIGYVA 706 Query 653 ALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLH 712 L+R G+T +H VPSLLG L LP + R L+ VP+GGE LPGEVADKF FDA L Sbjct 707 DLVRRRGVTVLHMVPSLLGSVLLLPEARELRGLRHVPVGGEALPGEVADKFATMFDAELR 766 Query 713 NFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGT 772 N YGPTE V+ ++ V GPQG IVPIGRP N ++LD +L+ VP GV+GE+Y+GG Sbjct 767 NHYGPTEAVVCSTYMSVRGPQGNSIVPIGRPNQNVYAYVLDQALKLVPAGVVGELYLGGA 826 Query 773 HVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRI 832 +A GY R LTAERFVADPF G R+YR+GDL RRNA G++EFVGRADEQVK+RG+RI Sbjct 827 QLARGYRARPVLTAERFVADPFGSGGRLYRTGDLVRRNARGELEFVGRADEQVKVRGYRI 886 Query 833 ELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVA 892 ELG++ A I DP VG V V D P++G L YV PA G +DLD +RAR Sbjct 887 ELGEIEAVIGADPRVGHCVATVVDDPQVGSLLAAYVVPAGGTR-----EIDLDELRARAQ 941 Query 893 AALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGEL 952 ALP YM+P A+ V+ EIP+T GK+D+ ALP P ++ FR P T TERR+ ++ L Sbjct 942 EALPAYMVPTAFAVIPEIPLTTSGKLDKRALPTPDALTERAFRLPVTPTERRMCAIYSHL 1001 Query 953 LGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH------ 1006 G++RVG DDSFF+LGGHSLLA +LVA +R FG+D+ VR +F+ T LA Sbjct 1002 FGKERVGLDDSFFELGGHSLLAARLVAQIRAQFGIDLTVRAVFDRPTPAGLAEQLVTYFR 1061 Query 1007 ------IDTLDSDSA----------RPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVN 1050 +D LD D + RP L + + LSSSQ+ WF + +G + Sbjct 1062 EEFEIELDELDLDESDEMEAAPQDGRPDLVAAERPERLPLSSSQLSMWFECQMEGVTDIG 1121 Query 1051 NIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGS 1110 N+ A GP T A AA+ DVVARHE LRT G P+QI+ P E+ V S Sbjct 1122 NMWLALRFDGPLQTPALIAALNDVVARHEALRTNIAIHEGAPYQIVHPSRELAVPILRSS 1181 Query 1111 DAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLVVHHIAGDHWSAGVLFTDL 1169 L L R ++F LET+ IR A++ + ++ VL+LVVHHI DH S V+ DL Sbjct 1182 PEG-LSDTLAELRHHIFGLETESLIRPAIIELSAQEHVLALVVHHIVVDHASFTVIVDDL 1240 Query 1170 LTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGL 1229 + AYRAR GQ P W P PVQYADY +WQ + + ++W +QL G+ E + Sbjct 1241 IAAYRARLEGQAPQWDPQPVQYADYVLWQRDAFAPDSEFGQAEVNFWRQQLAGVPTEIAV 1300 Query 1230 RPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVD 1289 D RP +L G+ +F + R L ++ GVTEFM+ QAA+AVVLH+ GGG D Sbjct 1301 AHDRARPQILGKRGEVAKFVMEPERRQALTRMAEQRGVTEFMVYQAALAVVLHRLGGGTD 1360 Query 1290 VPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPF 1349 + IG+PVA R ++ +L+G F N+V LRNDL G+P+LR VL+R+R L A+AHQ+LP Sbjct 1361 IVIGSPVAARVHPHVAKLVGLFANMVALRNDLSGDPSLRSVLERSRDATLNAHAHQELPI 1420 Query 1350 DQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLS 1409 +++VEAVNP RSLS NPLF +V+ R D G+TT+ L D + DL+ Sbjct 1421 EKLVEAVNPVRSLSWNPLFQTMVNFRGADWGTAARDVTVSGETTVVPLPMEVDVSYLDLN 1480 Query 1410 VNFFACGDEYRG----HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 FA G V+ +LY+ T + A L +AF + + + E+ ++ A Sbjct 1481 ---FALNVTPSGGLDVSVVANADLYDHETTRMIAQALDTAFDAFVNNQESRVSEIVLLPA 1537 Query 1466 QARRRIL 1472 A +++ Sbjct 1538 DAMAQLM 1544 Score = 131 bits (329), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 141/497 (29%), Positives = 218/497 (44%), Gaps = 55/497 (11%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 L+ Q R WF D + NI A + G D A+ V+ RH++LRTVY + Sbjct 44 LAPGQRRMWFMQTKDPADTSLNICVAHRMRGALDQTRLRDAVAAVIRRHDVLRTVYGVDS 103 Query 1089 GGVPHQIIQPPAEVPVRCAAGSDAA------WLRAELNNERGYVFDLETDWPIRAALLST 1142 G P+Q+ EVP +D +RA ++E G FDL D P+R LL Sbjct 104 AGEPYQLFVEEFEVPWTAVDLTDLTGDAQDRQVRALADSEFGRPFDLAADRPLRVTLLRL 163 Query 1143 -PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARST-GQRPSWAPL-----PVQYADYS 1195 E V+ LVVHHI D S V F +L Y R G+ P + + P AD + Sbjct 164 GAEDFVVLLVVHHICWDDNSWEVFFAELSEYYHGRPVQGEAPQFMVVSADTEPSSDADLT 223 Query 1196 VWQSAL--LDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAA 1253 W+ AL L D + G Y R LA P PA + Sbjct 224 YWRRALTPLPDPLELPGAASTYSSRAARRLA--------VPMPAETAA------------ 263 Query 1254 IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFIN 1313 ++ +R+ T FM+L AA V++H+ G D PVA R ++N ++ IG+F N Sbjct 264 ---RIEEFAREHSATPFMVLLAAFGVLVHRYTGSRDFVTAIPVAER-KSNAEKAIGYFGN 319 Query 1314 IVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVH 1373 ++LR + + + + R++ L A+ HQ++ D+VV VNP RS+ + + D +V Sbjct 320 TLLLRTVVNPDDSFASHVAAVREVCLDAFGHQNVGIDEVVREVNPSRSIGHDGM-DELVR 378 Query 1374 VREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVI---YRTELY 1430 + M +D D T L+ +AQ LS A E G ++ Y+T++ Sbjct 379 LGFSMRKDASGYRLEGVDVTQ--LDLAAVSAQLPLS---LAIATESSGTIVEFEYQTDVL 433 Query 1431 ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA----GAGTARVYL 1486 + + R++ RP++ L +E+ A+ +LD+S+ + V L Sbjct 434 PQWLVGQLLVHYQRLLADGLSRPEETLARLELFDAEEHSALLDQSHGVLTRPSAATLVDL 493 Query 1487 LDDALKPVP--VGVVGD 1501 LD A + P + VV D Sbjct 494 LDAAARATPEALAVVSD 510 Score = 92.0 bits (227), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 65/169 (39%), Positives = 90/169 (54%), Gaps = 16/169 (9%) Query 1522 TRFVADP----FAAQPGSRLYRNGERGVWKADGQLELLAEIERLPTAQAAPV--PAEPAD 1575 TR +A F A ++ R E + AD +L+A P A PV P+ Sbjct 1507 TRMIAQALDTAFDAFVNNQESRVSEIVLLPADAMAQLMAP----PAAAVEPVTTPSVEGS 1562 Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPV 1635 ET+ L +IL ++LE+ +V D+FF LGGDS+++ Q + RA + G+ +T +MVFE Sbjct 1563 EETKLVLISILEELLEISDVDPEDNFFALGGDSVISIQWSTRAAERGLAMTPQMVFECAT 1622 Query 1636 LCELAAAVDAKPHVEAEPDDK------HHAPMSTSGLSPDELSALTASW 1678 + +LA AVDA V E D APMS SGLS D L+ LTASW Sbjct 1623 IAQLAGAVDAADRVVTEGDSHLVTPPVQSAPMSASGLSADALAELTASW 1671 Score = 66.2 bits (160), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 37/71 (53%), Positives = 44/71 (62%), Gaps = 2/71 (2%) Query 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERG 1544 Y+LD ALK VP GVVG++Y GG ARP TA RFVADPF + G RLYR G+ Sbjct 804 YVLDQALKLVPAGVVGELYLGGAQLARGYRARPVLTAERFVADPFGS--GGRLYRTGDLV 861 Query 1545 VWKADGQLELL 1555 A G+LE + Sbjct 862 RRNARGELEFV 872 Score = 46.6 bits (109), Expect = 0.045, Method: Compositional matrix adjust. Identities = 29/66 (44%), Positives = 37/66 (57%), Gaps = 1/66 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TER + AI + + VG D FF LGG S+LA ++ A+ R GI LT R VF+ P Sbjct 988 TPTERRMCAIYSHLFGKERVGLDDSFFELGGHSLLAARLVAQIRAQFGIDLTVRAVFDRP 1047 Query 1635 VLCELA 1640 LA Sbjct 1048 TPAGLA 1053 >gi|317506256|ref|ZP_07964075.1| amino acid adenylation domain-containing protein [Segniliparus rugosus ATCC BAA-974] gi|316255502|gb|EFV14753.1| amino acid adenylation domain-containing protein [Segniliparus rugosus ATCC BAA-974] Length=1607 Score = 1151 bits (2978), Expect = 0.0, Method: Compositional matrix adjust. Identities = 673/1479 (46%), Positives = 885/1479 (60%), Gaps = 68/1479 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MW Q DP + LNIC+ +R+ GD+D L AV V+RRH LRTT+ +G DG + Sbjct 41 MWLAQNQDPESSTLNICLGFRLVGDLDAVELGRAVAEVSRRHEALRTTFELGADGELRSQ 100 Query 61 VHADLRPGWTQYDLTDLSQRAQRL-RLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 VH +L P + +DL++LS+ R RL+VLA+R+F PF+LS ++PLR++V R DEHV Sbjct 101 VHEELSPAFALHDLSELSEPQSRAQRLQVLARRDFARPFDLSAESPLRVSVFRLGPDEHV 160 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAI 179 L L AHHIAWDD SW VFF D+ AY +L + + YWR Sbjct 161 LALTAHHIAWDDDSWSVFFHDVDVAYRGGELPPPE------PEPEASPASAQSVAYWRDE 214 Query 180 MADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGA 239 +A PEPLELPG AG +S RA R + PA+ AAR+ A G T +MVLLAAF A Sbjct 215 LARLPEPLELPGAAGAGSGSSPRANRHEVEAPAELAARLEEFADEVGATSFMVLLAAFAA 274 Query 240 LVHRYT--------HSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLT 291 V R+ + +F V+ PV RG YFGN + +R +A S R L Sbjct 275 TVRRHCPAQGAEAENVSEFFVSVPVGGRGGSGSRIG-YFGNVLLLRCSVDAADSLRSLAR 333 Query 292 ATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERY 351 TR++ AFAHQ ++L V G+ RV F R G G+ ER Sbjct 334 RTRELCLAAFAHQDLDLSEAVAV----GAKGSAEAARVGFSVRGA-GECLRIGGMAAERI 388 Query 352 DLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTL 411 DLRS +TQLPL VE +G ++E EH V+++ +A R + LL ALA PD L Sbjct 389 DLRSPVTQLPLSVAVEQGASGAVIEVEHRVDVVPDEVAAGFARRYARLLAGALAEPDRPL 448 Query 412 SGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLN 471 S + L+ A + S G + L L+ E+ PDA A+V++G Y +L Sbjct 449 SQIDLLGAERAEEI-ACSCGAPAAPEARLLHVLIEERIAAAPDAVALVWDGGESRYGELG 507 Query 472 EASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFI 531 +NRL WL+ +G+G+ED VA+ L + I L V+K+G +VPVDP+YP++R++ + Sbjct 508 ARANRLARWLVGRGVGAEDVVALQLGVCVEFIPAVLAVLKAGGAFVPVDPAYPRERIEHM 567 Query 532 LADCDAKLVL-----RTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGV 586 L+D KLVL E G D D DR RPLRP+N AY++YTSG+TG PKGV Sbjct 568 LSDARPKLVLDAKALAEAEAEAEGLADHDLDDTDRARPLRPENLAYIVYTSGSTGKPKGV 627 Query 587 AVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLT 646 AV HR +A + Y + DRL+Q+ S SFD S EIF L GA +V+P PG T Sbjct 628 AVAHREIAAHMRGMADNYGLGAEDRLVQLTSVSFDASFFEIFTPLIVGASVVVPEPGVAT 687 Query 647 DIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHAT 706 D+ L AL+ G+T MH VPSLL L+LP S RTL+RVP+GGE L GE+ K A Sbjct 688 DVPALGALVARHGVTVMHMVPSLLDAILALPEASALRTLRRVPVGGEALSGELVAKAGAL 747 Query 707 FDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 + L NFYGPTE V+ A+ V P G + PIG+P +LLDD+L+ VP+GV+GE Sbjct 748 WGVELDNFYGPTEAVVCATGQIGVRPAGAALAPIGKPLAGARAYLLDDALELVPSGVVGE 807 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVK 826 IY+GG H+A GY LTAERFVADPF G+RMYR+GDLARRNA G +EFVGRADEQVK Sbjct 808 IYLGGEHLARGYLGSPALTAERFVADPFCQGARMYRTGDLARRNAAGQLEFVGRADEQVK 867 Query 827 IRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDR 886 IRGFRIELG+VAAA+A P V Q VVV +DLP GKSLV YVTP+ G +++ + Sbjct 868 IRGFRIELGEVAAAVAAHPDVAQCVVVAADLPGAGKSLVAYVTPSEG-------SLEVAQ 920 Query 887 IRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLA 946 I+A+ A LP +M PA + +D IP+T GK+DR ALPEPQ A+ EFR P T ERRLA Sbjct 921 IKAQAATVLPAHMRPAVVMQVDRIPLTPSGKLDRKALPEPQAATSVEFRPPATEDERRLA 980 Query 947 QLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH 1006 ++F +LG +RVGADDSFFDLGGHSLLAT+LVA +R FG +V VR F+ T LA Sbjct 981 EIFASVLGVERVGADDSFFDLGGHSLLATRLVARIRAEFGFEVPVRAPFDAPTPAELAAM 1040 Query 1007 IDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNA 1066 + T + LTR V LS +Q+ WF R G V NIPFAA L GP D A Sbjct 1041 LTTCRQSAEGAALTRRPRPERVPLSYAQLAIWFQQRLVG-GTVLNIPFAARLTGPLDVAA 1099 Query 1067 FAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYV 1126 AAA DV+ RHE+LRT + E GVP+Q++ PPA P +A D A +V Sbjct 1100 LAAAFGDVLERHEVLRTTFPEADGVPYQLVLPPA--PFEFSA--DVA----------DHV 1145 Query 1127 FDLETDWPIRAALL-STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWA 1185 FDL + PIRA L+ + E+ VL++VVHHIA DHWSAGVLF DL AY+AR G+ P+W Sbjct 1146 FDLARELPIRAGLVRNGAEEHVLTIVVHHIAADHWSAGVLFADLSAAYQARLGGRAPTWE 1205 Query 1186 PLPVQYADYSVWQSALL----DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSG 1241 PL QYAD+++WQ DG DYW+ L G + D PRP +L Sbjct 1206 PLAAQYADFALWQQERFAGSGRDGKPESAEHFDYWVEALAGAPRRIDVAHDKPRPPVLGV 1265 Query 1242 AGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSE 1301 AG +VE + A+ +L ++R +EFM+LQAAVA++L + G G D+PIG+PV+GRS+ Sbjct 1266 AGGSVEASVPFAVVGRLRELARAESASEFMVLQAAVALLLRQFGAGEDIPIGSPVSGRSD 1325 Query 1302 ANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRS 1361 D L+G F N+VVLR D+ G+PT RE+++R+R+++L AY HQDLP +++VE ++PQRS Sbjct 1326 LGADGLVGVFANMVVLRADVSGDPTARELVRRSRRVSLDAYQHQDLPIERLVETISPQRS 1385 Query 1362 LSRNPLFDIVVHVRE---QMPQ--DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACG 1416 S NPLF +++H RE ++P +H+ ++L F A DLS NFF Sbjct 1386 RSYNPLFQVMMHYREAETELPAFGEHL---------AAQMLRLPFGTAYLDLSFNFFTSA 1436 Query 1417 DEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQ 1455 +E ++Y T+LYERATAQR L+RV+E FAD PD Sbjct 1437 EEVSASIVYNTDLYERATAQRLLAELLRVLEVFADDPDS 1475 Score = 82.4 bits (202), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 57/106 (54%), Positives = 72/106 (68%), Gaps = 0/106 (0%) Query 1573 PADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFE 1632 P T TER LAA+L ++LE+ ++ R D FF LGGDS+L+ Q A RA D G+ LT +MVFE Sbjct 1499 PPATPTERTLAALLEELLEIDDIRRGDGFFALGGDSVLSVQWARRANDAGLALTPQMVFE 1558 Query 1633 HPVLCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASW 1678 H L LAAAVDA + + D+ HAPMS SGLS D L++L SW Sbjct 1559 HASLSGLAAAVDAADPAQEQNGDRSHAPMSVSGLSEDMLASLAESW 1604 Score = 79.0 bits (193), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 127/528 (25%), Positives = 199/528 (38%), Gaps = 69/528 (13%) Query 1021 RVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEI 1080 R + P S++Q R W D ++ NI L G D A+ +V RHE Sbjct 25 RAEQAPPSGPSAAQRRMWLAQNQDPESSTLNICLGFRLVGDLDAVELGRAVAEVSRRHEA 84 Query 1081 LRTVYR-----EIGGVPHQIIQPP---AEVPVRCAAGSDAAWLRAELNNERGYVFDLETD 1132 LRT + E+ H+ + P ++ S A L+ + FDL + Sbjct 85 LRTTFELGADGELRSQVHEELSPAFALHDLSELSEPQSRAQRLQVLARRDFARPFDLSAE 144 Query 1133 WPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQY 1191 P+R ++ P++ VL+L HHIA D S V F D+ AYR Sbjct 145 SPLRVSVFRLGPDEHVLALTAHHIAWDDDSWSVFFHDVDVAYRGGELPPPEP-----EPE 199 Query 1192 ADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLG 1251 A + QS YW +L L L + S + E Sbjct 200 ASPASAQSVA-------------YWRDELARLPEPLELPGAAGAGSGSSPRANRHEVEAP 246 Query 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLI--- 1308 A + +L + ++G T FM+L AA A + + P G N+ + Sbjct 247 AELAARLEEFADEVGATSFMVLLAAFAATVRR---------HCPAQGAEAENVSEFFVSV 297 Query 1309 ------------GFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAV 1356 G+F N+++LR + +LR + +RTR++ LAA+AHQDL + V AV Sbjct 298 PVGGRGGSGSRIGYFGNVLLLRCSVDAADSLRSLARRTRELCLAAFAHQDLDLSEAV-AV 356 Query 1357 NPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACG 1416 + S + V E + G + + P Q LSV Sbjct 357 GAKGSAEAARVGFSVRGAGE------CLRIGGMAAERIDLRSPV---TQLPLSVAVEQGA 407 Query 1417 DEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 V +R ++ A FA R++ PD+PL +++++ A+ I Sbjct 408 SGAVIEVEHRVDVVPDEVAAGFARRYARLLAGALAEPDRPLSQIDLLGAERAEEIACSCG 467 Query 1477 A-GAGTARVY--LLDDALKPVPVGVV-----GDVYYGGGPAVGARLAR 1516 A A AR+ L+++ + P V G+ YG A RLAR Sbjct 468 APAAPEARLLHVLIEERIAAAPDAVALVWDGGESRYGELGARANRLAR 515 Score = 71.2 bits (173), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/74 (53%), Positives = 47/74 (64%), Gaps = 2/74 (2%) Query 1482 ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNG 1541 AR YLLDDAL+ VP GVVG++Y GG L P+ TA RFVADPF G+R+YR G Sbjct 788 ARAYLLDDALELVPSGVVGEIYLGGEHLARGYLGSPALTAERFVADPFCQ--GARMYRTG 845 Query 1542 ERGVWKADGQLELL 1555 + A GQLE + Sbjct 846 DLARRNAAGQLEFV 859 Score = 57.8 bits (138), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 41/83 (50%), Positives = 48/83 (58%), Gaps = 2/83 (2%) Query 1561 LPTAQAA-PVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR 1619 LP QAA V P TE ER LA I A VL V VG D FF+LGG S+LAT++ AR R Sbjct 957 LPEPQAATSVEFRPPATEDERRLAEIFASVLGVERVGADDSFFDLGGHSLLATRLVARIR 1016 Query 1620 -DGGIPLTARMVFEHPVLCELAA 1641 + G + R F+ P ELAA Sbjct 1017 AEFGFEVPVRAPFDAPTPAELAA 1039 >gi|240169923|ref|ZP_04748582.1| non-ribosomal peptide synthetase MbtE [Mycobacterium kansasii ATCC 12478] Length=1661 Score = 1138 bits (2943), Expect = 0.0, Method: Compositional matrix adjust. Identities = 663/1490 (45%), Positives = 881/1490 (60%), Gaps = 39/1490 (2%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+Q D LNICV+YR+TG +D+AR+R AV+ V RH ILRTTY V G Sbjct 51 MWFLQAMDAGDPTLNICVAYRLTGALDVARMRAAVSHVVARHAILRTTYGVDASGEPYQV 110 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 D+ W D + + Q + ++ +A+ EF PF+L+R+ PLRI+++RT ADE VL Sbjct 111 FTDDVEIPWRTIDTSQVPQHERNQHVDTIARDEFGRPFDLTRELPLRISLIRTGADEFVL 170 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSA----ASGPDTTEADLNYW 176 LLV HHI WDD SW++FF DL+ AY+ P+ +A GP T D+ YW Sbjct 171 LLVVHHICWDDDSWKIFFDDLSAAYNHGPQPNSPAPQFVATAVLDNTIGPSDT--DIEYW 228 Query 177 RAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 R + PEP +LPG A S RA R T LPA RV A+ +P+MVLL A Sbjct 229 RNRLQPLPEPPDLPGAAAP--DPSRRAERRTRALPAGLLQRVEGFAREHSASPFMVLLTA 286 Query 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 F ALV RY + DFLV+ PV R A E AIGYFGN V +R+ +F L R+ Sbjct 287 FSALVRRYAGASDFLVSVPVTERSAAAEAAIGYFGNIVLLRIVSGPDDTFAALTDTVRET 346 Query 297 ASGAFAHQRINLDRVVRELNPDR---RHGAERMTRVSFGFREPDGGGFNPPGIECERYDL 353 G FAH+ + +DRVVR +NP R R G +R+ R+ F R+ GF+ G+ + +L Sbjct 347 CLGGFAHRSVGIDRVVRAVNPQRSAGRDGLDRLVRLGFSMRK-SVDGFSFDGVTARQLEL 405 Query 354 RSNITQLPLGFMVEF---DRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNT 410 + QLPL + F D V VE E+ V++L L +ML H+ LLDNAL AP + Sbjct 406 GAVTAQLPLSLAIVFEPEDPEQVAVEFEYHVDVLAGPLVDRMLTHYLRLLDNALRAPGDR 465 Query 411 LSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDL 470 L+GL ++ + + S GE TP T+V L+ P+ A+V + +Y +L Sbjct 466 LTGLDMLGPTERGAILAQSHGELVSTPATTMVALLESAAATAPERVALVSDDAELSYAEL 525 Query 471 NEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDF 530 + +NRL WLI GIG+ED V + + S + +V V+K+GA Y+P+DP+YPQDR+D+ Sbjct 526 HRRANRLARWLIRHGIGAEDIVGLRMATSVEFVVAMFAVLKAGAAYLPIDPAYPQDRIDY 585 Query 531 ILADCDAKLVLR----TPVRELAGYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKG 585 ++ D + K+VL + A + DD TDADRIRPL P + AY+IYTSG+TG PKG Sbjct 586 LITDTEPKMVLGHHDFDAAEQAAAHLPDDVLTDADRIRPLHPAHLAYVIYTSGSTGRPKG 645 Query 586 VAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGL 645 VAVPH+ +AE+ F E+ + DRLLQ +S SFD S+ +IF TL+ GAR+++P+PG Sbjct 646 VAVPHQAIAEHVDGFIAEWSMTADDRLLQSSSVSFDASLLDIFVTLSLGARLIVPKPGAF 705 Query 646 TDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHA 705 DI Y+ L+ +T +H VPS+L L LP + +WR L+ VP+GGE LPGE+ADKF Sbjct 706 ADIPYVADLISRHRVTVLHMVPSMLSTLLLLPQIDEWRQLRHVPVGGEALPGELADKFAR 765 Query 706 TFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIG 765 FDA L N YGPTE V+ A+ +V GPQGT +VPIG P N ++LD LQPVP GV+G Sbjct 766 HFDAELRNHYGPTEAVVCATHLQVSGPQGTGVVPIGVPNRNVYAYVLDSELQPVPAGVVG 825 Query 766 EIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQV 825 E+Y+GGT +A GY R GLTA+RFVADPFNPG R+YRSGDL RRN G +EFVGRADEQV Sbjct 826 ELYLGGTQLARGYLGRPGLTAQRFVADPFNPGMRLYRSGDLVRRNLSGQLEFVGRADEQV 885 Query 826 KIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLD 885 KIRGFRIELG+V + IA P V +VV D G +L Y+ PAAG GP VG+D D Sbjct 886 KIRGFRIELGEVESVIATHPAVRHCLVVAEDTAT-GPALAAYLVPAAGESGPT-VGIDFD 943 Query 886 RIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRL 945 IRA AA LP+YM+P A+ V+ EIP+ GK+D+ ALP + R P TA ERR+ Sbjct 944 DIRAHAAAVLPDYMVPGAFAVIREIPLGVSGKLDKRALPAATPITARRCREPATAAERRM 1003 Query 946 AQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAG 1005 +F L G V DDSFF LGGHSLLA +L+A + FGV + VR +F+ T LA Sbjct 1004 CGIFARLFGCRDVSVDDSFFGLGGHSLLAARLIAQIHAEFGVRLNVRAVFDTPTPAGLAA 1063 Query 1006 H-IDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDT 1064 +D + ARP L LS SQ+ WF+YR G N V N+ A GP DT Sbjct 1064 RLVDAPELRGARPELVTAARPPWPPLSYSQLAMWFHYRMRGANDVFNMALALRFDGPLDT 1123 Query 1065 NAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEV--PVRCAAGSDAAWLRAELNNE 1122 A AI DVVARHE+LRT + E GVP+Q++ P V VR + A + AEL Sbjct 1124 AALLEAINDVVARHEVLRTNFVEHEGVPYQLVHPAMRVQLEVRDVSADQADQVLAEL--- 1180 Query 1123 RGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQR 1181 R +VF LE++ IR LL P VL ++VHHI DH S GV+ DL+TAYRAR Sbjct 1181 RRHVFTLESEPLIRPTLLRLGPATHVLLVLVHHIVTDHSSFGVVVDDLITAYRARLRAGP 1240 Query 1182 PSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSG 1241 P W P+Q+AD++VWQ D+ + +W + L GL G+ + D RP +L Sbjct 1241 PQWFEAPLQFADFAVWQRNTFDEPGEWGHVELAWWRQVLAGLPGDISIALDHTRPPVLGR 1300 Query 1242 AGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSE 1301 G+ V F + A R L ++ D G TEFM+ AA+AVVLHK GGG D+ +G+PVA R + Sbjct 1301 RGEVVTFTVSAPRRTALTRLAEDHGATEFMVYHAALAVVLHKLGGGTDLAVGSPVAARVD 1360 Query 1302 ANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRS 1361 +QL G N+VVLR+DL +P+LR +L +R L A AHQ+LP +++VEA+NP RS Sbjct 1361 RATEQLAGPCANVVVLRSDLSDDPSLRGILIGSRDTVLGALAHQELPIERLVEAINPPRS 1420 Query 1362 LSRN-PLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACG 1416 SRN PLF +H R +P+D TG DG TT+ L F+ + DL+V Sbjct 1421 PSRNHPLFQHSIHFRGHDWALLPRDL---TG-DGATTVVALSMDFEVSLLDLNVGLDVTP 1476 Query 1417 DEYRG-HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 D V+ +LYE + Q A L ++AFA PD L V ++ A Sbjct 1477 DGGLAVRVVANADLYEPDSVQLIASALDAALDAFATMPDAALSTVCLLPA 1526 Score = 133 bits (334), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 149/499 (30%), Positives = 216/499 (44%), Gaps = 53/499 (10%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-REI 1088 LS+ Q R WF D + NI A L G D AA++ VVARH ILRT Y + Sbjct 44 LSTGQRRMWFLQAMDAGDPTLNICVAYRLTGALDVARMRAAVSHVVARHAILRTTYGVDA 103 Query 1089 GGVPHQIIQPPAEVPVRCAAGSDAAWLRAELN--------NERGYVFDLETDWPIRAALL 1140 G P+Q+ E+P R S + E N +E G FDL + P+R +L+ Sbjct 104 SGEPYQVFTDDVEIPWRTIDTSQVP--QHERNQHVDTIARDEFGRPFDLTRELPLRISLI 161 Query 1141 ST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQS 1199 T ++ VL LVVHHI D S + F DL AY + G +P+ +P P A + Sbjct 162 RTGADEFVLLLVVHHICWDDDSWKIFFDDLSAAY---NHGPQPN-SPAPQFVA------T 211 Query 1200 ALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFR--------LG 1251 A+LD+ G +YW +L L P P L GA R L Sbjct 212 AVLDNTIGPSDTDIEYWRNRLQPL----------PEPPDLPGAAAPDPSRRAERRTRALP 261 Query 1252 AAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFF 1311 A + ++ +R+ + FM+L A + ++ + G D + PV RS A + IG+F Sbjct 262 AGLLQRVEGFAREHSASPFMVLLTAFSALVRRYAGASDFLVSVPVTERSAAA-EAAIGYF 320 Query 1312 INIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIV 1371 NIV+LR + T + R+ L +AH+ + D+VV AVNPQRS R+ L + Sbjct 321 GNIVLLRIVSGPDDTFAALTDTVRETCLGGFAHRSVGIDRVVRAVNPQRSAGRDGLDRL- 379 Query 1372 VHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNF-FACGDEYRGHV--IYRTE 1428 VR +D T R LE AQ LS+ F D + V Y + Sbjct 380 --VRLGFSMRKSVDGFSFDGVTARQLELGAVTAQLPLSLAIVFEPEDPEQVAVEFEYHVD 437 Query 1429 LYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN----AGAGTARV 1484 + R +R+++ P L ++M+ R IL +S+ + T V Sbjct 438 VLAGPLVDRMLTHYLRLLDNALRAPGDRLTGLDMLGPTERGAILAQSHGELVSTPATTMV 497 Query 1485 YLLDDALKPVP--VGVVGD 1501 LL+ A P V +V D Sbjct 498 ALLESAAATAPERVALVSD 516 Score = 70.5 bits (171), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/132 (43%), Positives = 65/132 (50%), Gaps = 26/132 (19%) Query 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERG 1544 Y+LD L+PVP GVVG++Y GG L RP TA RFVADPF PG RLYR+G+ Sbjct 810 YVLDSELQPVPAGVVGELYLGGTQLARGYLGRPGLTAQRFVADPF--NPGMRLYRSGDLV 867 Query 1545 VWKADGQLEL----------------LAEIERL----PTAQAAPVPAEPADTETERALAA 1584 GQLE L E+E + P + V AE DT T ALAA Sbjct 868 RRNLSGQLEFVGRADEQVKIRGFRIELGEVESVIATHPAVRHCLVVAE--DTATGPALAA 925 Query 1585 ILADVLEVGEVG 1596 L V GE G Sbjct 926 YL--VPAAGESG 935 Score = 52.4 bits (124), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 39/84 (47%), Positives = 52/84 (62%), Gaps = 7/84 (8%) Query 1556 AEIERLPTAQAAPVPAEPADT------ETERALAAILADVLEVGEVGRYDDFFNLGGDSI 1609 A++E L A PV AEP + ETER L A+L ++LE+ +V D+FF LGGDSI Sbjct 1527 ADLETL-FAPPTPVDAEPTRSVTGGSAETERTLIALLEELLEISDVDPDDNFFALGGDSI 1585 Query 1610 LATQVAARARDGGIPLTARMVFEH 1633 ++ Q +ARA G+ LT MVF H Sbjct 1586 VSVQWSARAAAHGLALTPAMVFAH 1609 Score = 41.6 bits (96), Expect = 1.4, Method: Compositional matrix adjust. Identities = 33/85 (39%), Positives = 44/85 (52%), Gaps = 3/85 (3%) Query 1572 EPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMV 1630 EPA T ER + I A + +V D FF LGG S+LA ++ A+ + G+ L R V Sbjct 994 EPA-TAAERRMCGIFARLFGCRDVSVDDSFFGLGGHSLLAARLIAQIHAEFGVRLNVRAV 1052 Query 1631 FEHPVLCELAA-AVDAKPHVEAEPD 1654 F+ P LAA VDA A P+ Sbjct 1053 FDTPTPAGLAARLVDAPELRGARPE 1077 >gi|262200637|ref|YP_003271845.1| amino acid adenylation domain-containing protein [Gordonia bronchialis DSM 43247] gi|262083984|gb|ACY19952.1| amino acid adenylation domain protein [Gordonia bronchialis DSM 43247] Length=1693 Score = 1129 bits (2919), Expect = 0.0, Method: Compositional matrix adjust. Identities = 652/1524 (43%), Positives = 897/1524 (59%), Gaps = 84/1524 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFVQ DP+ LN+CV+YR++G +D ARL A V RH ILR+TY V ++G Sbjct 48 MWFVQNLDPTDTTLNVCVAYRLSGPLDAARLHQACADVVARHEILRSTYGVDENGEPFQV 107 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 A + W Q DL +L + + A+REF PF+L+ D P+R++++R A +EH+L Sbjct 108 SAAAVELPWQQDDLRELPVDRRESQAHEWARREFARPFDLTADIPIRVSLLRIADEEHIL 167 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGP-DTTEADLNYWRAI 179 +LV HH+ WDD SW VFFT++ AY + + P AA G +A+L++WR Sbjct 168 VLVVHHVGWDDESWPVFFTEVNAAYRGEQV--PVPPVQYVDAALGNRPADDAELDFWRGE 225 Query 180 MADPPEPLELPGPAGTCVPTSWR---AARATLRLPADTAARVATMAKNTGCTPYMVLLAA 236 ++ PP +E G P + R A A+ ++ ++ +A+ TP+ VLL A Sbjct 226 LSPPPGRVEF----GRTQPGTARSRDAGCASRQVSPALTEQIVGLARAHATTPFTVLLTA 281 Query 237 FGALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDI 296 F A + Y+ + DFLV+ PV+NRGA E IGYFGN V +R +P+ F LL RD Sbjct 282 FEAAIQFYSGATDFLVSVPVVNRGANAEKLIGYFGNAVLLRAQPEPTSDFAALLDRVRDA 341 Query 297 ASGAFAHQRINLDRVVRELNPDRRHGAERMTR---VSFGFREPDGGGFNPPGIECERYDL 353 +S AFAHQ + LDRVVRE++P R G + +T+ VSF R GGF+ G++ Sbjct 342 SSAAFAHQNVGLDRVVREVSPPRSGGGDALTQLVQVSFSSRSA-AGGFDLDGVDVAELPW 400 Query 354 RSNITQLPLGFMVEFDRAGVL-VEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLS 412 S + LG ++ D +G L VEA + L P L +Q L H+ LL A+ P L Sbjct 401 HSAVAPEDLGLLIVGDGSGGLRVEATYQTAALTPELVEQFLDHYLRLLTAAVGDPSTPLR 460 Query 413 GLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNE 472 + ++ E + ARL S G + DTP T+V LV Q TP AV+ + H T+ DL+ Sbjct 461 DIDILGEAERARLSAASHGRQVDTPATTMVALVESQAASTPTNDAVISDTDHLTFADLDT 520 Query 473 ASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL 532 +NRL HW+I QGIG+ED VA+ + S + IV +L V+K+GA Y+P+DP+YP DR+D++ Sbjct 521 RANRLAHWMIGQGIGTEDIVALRMTTSVEFIVASLAVLKAGAAYLPMDPAYPADRIDYLR 580 Query 533 ADCDAKLVLR-----TPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVA 587 AD L L V + Y + DP DADR+RPLRP NTAY+IYTSG+TG PKGV Sbjct 581 ADARPALELDFDGYGHAVTSASAYPATDPVDADRVRPLRPANTAYVIYTSGSTGQPKGVP 640 Query 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 VPH +AE+ + F E+ + DR+LQ S SFD S+ +I+ TL GA +V+P+ D Sbjct 641 VPHNAIAEHLLGFNDEWALTTDDRVLQSTSVSFDASLLDIYVTLTAGACVVVPKANAYRD 700 Query 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 I Y+ L+ +G+T +H VPS+L FL LP + W TL+ VP+GGE L GE+AD+F F Sbjct 701 IPYVADLVSRQGVTVLHMVPSMLATFLMLPEAADWSTLRHVPVGGEALVGEIADRFATQF 760 Query 708 DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEI 767 DA L N YGPTE V++++ +V GPQG +VPIG P N +++LDD+L+ VP GV GEI Sbjct 761 DAHLRNHYGPTEAVVSSTHMEVEGPQGAGVVPIGIPNQNVDLYILDDALRLVPDGVAGEI 820 Query 768 YIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKI 827 Y+GG +A GY RAGLTA+RFVADPF PG+R+YR+GDL RR G+I+F+GRADEQVK+ Sbjct 821 YLGGNQLARGYLHRAGLTAQRFVADPFRPGARLYRTGDLVRRKPSGEIDFLGRADEQVKV 880 Query 828 RGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRI 887 RGFRIELG+V I V AVV+V D P G +L Y+ AG D DV + I Sbjct 881 RGFRIELGEVETTITEHDDVAHAVVIVVDDPVAGPALAAYLV--AGPDSSPDV----EAI 934 Query 888 RARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQ 947 R+ VA LP +M+PA + V++E+P+TAHGK+D+ ALP P+ + E+R P T+ E+R+A Sbjct 935 RSYVAGRLPAHMVPATFTVIEEVPLTAHGKLDKRALPAPEAVAAPEYREPTTSAEKRVAA 994 Query 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI 1007 L G L RD+VGADDSFF LGGHSLLA +L+ VR FGV++ +R F+ TVTALA I Sbjct 995 LLGSLFQRDQVGADDSFFTLGGHSLLAARLITMVRAEFGVELDMRVPFDSPTVTALAAAI 1054 Query 1008 D---------TLDSDSARPRL---------------------------TRVDHDGPVRLS 1031 +LD P L TR ++ + LS Sbjct 1055 GEAFFDEFGISLDEFDGDPELDVDTGAYGAATADADAAPAVGMVPTPQTRSEY---IPLS 1111 Query 1032 SSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGV 1091 SQ W R +G N+ + L GP D A AA+ DVVARHE LRT + E Sbjct 1112 YSQRAYWMQRRMEGAVDGENVTYPLRLEGPIDREALIAAVNDVVARHESLRTTFPEHNAT 1171 Query 1092 PHQIIQP--PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQ-TVL 1148 P+Q+I P P EVPV GS+ R EL+ + GYVFDL + +R LL EQ VL Sbjct 1172 PYQLIHPAQPIEVPVVELDGSEERLDR-ELDADAGYVFDLAAETLLRVRLLVLHEQDCVL 1230 Query 1149 SLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAG- 1207 S+++HHI D S + DL+TAYRAR GQ P W LP+ +AD+++WQ A D G G Sbjct 1231 SVLLHHIIADRSSCEIFAADLITAYRARVRGQAPEWPALPIGFADFAIWQRAAFDRGPGR 1290 Query 1208 ----IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSR 1263 + Q DYW L GL E + D PRP +L G + R+ A I ++ + Sbjct 1291 ELSDVGRRQLDYWREALAGLPDEINVAHDHPRPQILGHNGISTARRVPAEIWNRAITNAE 1350 Query 1264 DLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRG 1323 +G TEFML Q+ A VL+ G G D+ IGA VA R DQ+IG F N+VVLR+DL G Sbjct 1351 SVGATEFMLCQSVGASVLNALGAGDDLAIGAAVANRLGEATDQVIGLFANVVVLRSDLSG 1410 Query 1324 NPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHV 1383 +PT R VL+R R AL A HQ +PF+++VE +NP RSL+RNPLF +++HVR + + Sbjct 1411 DPTPRTVLERVRNSALDAITHQGVPFERLVETLNPPRSLARNPLFQVMMHVRHRATPEPF 1470 Query 1384 IDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRT----ELYERATAQRFA 1439 + DG TT R + ++ + D ++ + G +I R +LY+ AT + FA Sbjct 1471 SE---DGSTTFRDVAKFYEVSFMDFHFDYTV---DVNGDLILRIVVNPDLYDAATGEVFA 1524 Query 1440 DWLVRVVEAFADRPDQPLREVEMV 1463 D V V+EAFA+R D PL ++++ Sbjct 1525 DVTVGVLEAFANRVDAPLSALDVL 1548 Score = 143 bits (361), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 135/461 (30%), Positives = 197/461 (43%), Gaps = 41/461 (8%) Query 1027 PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR 1086 P LS +Q R WF D + N+ A L GP D A DVVARHEILR+ Y Sbjct 38 PSPLSDAQRRMWFVQNLDPTDTTLNVCVAYRLSGPLDAARLHQACADVVARHEILRSTYG 97 Query 1087 -EIGGVPHQI----IQPP------AEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1135 + G P Q+ ++ P E+PV W R E FDL D PI Sbjct 98 VDENGEPFQVSAAAVELPWQQDDLRELPVDRRESQAHEWARREFARP----FDLTADIPI 153 Query 1136 RAALLSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPL-PVQYAD 1193 R +LL E+ +L LVVHH+ D S V FT++ AYR P+ PVQY D Sbjct 154 RVSLLRIADEEHILVLVVHHVGWDDESWPVFFTEVNAAYRGEQV-------PVPPVQYVD 206 Query 1194 YSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAA 1253 ++ D + D+W +L G P A AG A ++ A Sbjct 207 AALGNRPADD-------AELDFWRGELSPPPGRVEFGRTQPGTARSRDAGCASR-QVSPA 258 Query 1254 IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFIN 1313 + +++ ++R T F +L A + G D + PV R AN ++LIG+F N Sbjct 259 LTEQIVGLARAHATTPFTVLLTAFEAAIQFYSGATDFLVSVPVVNRG-ANAEKLIGYFGN 317 Query 1314 IVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVH 1373 V+LR +L R R + AA+AHQ++ D+VV V+P RS + L +V Sbjct 318 AVLLRAQPEPTSDFAALLDRVRDASSAAFAHQNVGLDRVVREVSPPRSGGGDALTQLV-- 375 Query 1374 VREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRG---HVIYRTELY 1430 Q+ G + V E + +A A + GD G Y+T Sbjct 376 ---QVSFSSRSAAGGFDLDGVDVAELPWHSAVAPEDLGLLIVGDGSGGLRVEATYQTAAL 432 Query 1431 ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRI 1471 ++F D +R++ A P PLR+++++ R R+ Sbjct 433 TPELVEQFLDHYLRLLTAAVGDPSTPLRDIDILGEAERARL 473 Score = 94.4 bits (233), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 56/110 (51%), Positives = 68/110 (62%), Gaps = 7/110 (6%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPV 1635 TETER L A+L ++L++ +V R D FF LGGDS++A Q A RA G+PLT +MVFEH Sbjct 1580 TETERTLIALLEELLDIEDVEREDGFFALGGDSVIAIQWAGRAAAVGLPLTPQMVFEHFT 1639 Query 1636 LCELAAAVDAKPHVEAEPDDK-------HHAPMSTSGLSPDELSALTASW 1678 + ELAAAVD EPD APMS SGL D L+AL SW Sbjct 1640 MFELAAAVDDAIANPPEPDGTSDETAPAESAPMSVSGLGDDALAALKDSW 1689 Score = 65.9 bits (159), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 35/72 (49%), Positives = 46/72 (64%), Gaps = 2/72 (2%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 +Y+LDDAL+ VP GV G++Y GG L R TA RFVADPF +PG+RLYR G+ Sbjct 802 LYILDDALRLVPDGVAGEIYLGGNQLARGYLHRAGLTAQRFVADPF--RPGARLYRTGDL 859 Query 1544 GVWKADGQLELL 1555 K G+++ L Sbjct 860 VRRKPSGEIDFL 871 Score = 52.0 bits (123), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/83 (40%), Positives = 48/83 (58%), Gaps = 2/83 (2%) Query 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-D 1620 P A AAP EP T E+ +AA+L + + +VG D FF LGG S+LA ++ R + Sbjct 973 PEAVAAPEYREPT-TSAEKRVAALLGSLFQRDQVGADDSFFTLGGHSLLAARLITMVRAE 1031 Query 1621 GGIPLTARMVFEHPVLCELAAAV 1643 G+ L R+ F+ P + LAAA+ Sbjct 1032 FGVELDMRVPFDSPTVTALAAAI 1054 Score = 44.7 bits (104), Expect = 0.17, Method: Compositional matrix adjust. Identities = 31/83 (38%), Positives = 46/83 (56%), Gaps = 5/83 (6%) Query 926 PQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAF 985 P++++DT P T TER L L ELL + V +D FF LGG S++A + A A Sbjct 1571 PELSADT----PVTETERTLIALLEELLDIEDVEREDGFFALGGDSVIAIQW-AGRAAAV 1625 Query 986 GVDVGVREIFEFATVTALAGHID 1008 G+ + + +FE T+ LA +D Sbjct 1626 GLPLTPQMVFEHFTMFELAAAVD 1648 >gi|169629334|ref|YP_001702983.1| peptide synthetase MbtE [Mycobacterium abscessus ATCC 19977] gi|169241301|emb|CAM62329.1| Probable peptide synthetase MbtE [Mycobacterium abscessus] Length=1458 Score = 1127 bits (2914), Expect = 0.0, Method: Compositional matrix adjust. Identities = 605/1184 (52%), Positives = 772/1184 (66%), Gaps = 51/1184 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF P L+N+C SYR+ G++D+ +LR AV AV RH LRTT G DG Sbjct 36 IWFAHGVTP--VLMNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRTTVHAGADGHPVAV 93 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 +H+DL+ W ++D+TDL AQ LRL VLAQRE+ F+L+ +APLR+TV+RT + E+V+ Sbjct 94 LHSDLQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLRVTVIRTGSAEYVM 153 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIM 180 L+VAH I WDD SW+VF DLT AY + L SA +A ++YWR + Sbjct 154 LVVAHRIGWDDESWQVFLADLTAAYVHGGISEPLS-----SAPKQGGPGDAAVDYWREEL 208 Query 181 ADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 ++P EPLELPGP G VPT W+AAR T L +V +A+++G TP+ VLLAA+ L Sbjct 209 SNPAEPLELPGPNGAVVPTDWKAARCTAHLSVSVMEQVERLARDSGSTPHAVLLAAYSVL 268 Query 241 VHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGA 300 +HRYTH++DF+VA+PV IG+FGN + +R+RP++ SF++LL R Sbjct 269 LHRYTHANDFIVASPVPALDPHARGRIGHFGNVLPLRMRPRADESFKDLLARVRRTTLDG 328 Query 301 FAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQL 360 AHQ ++LDRVV RV F F PPGI CE+ S++ + Sbjct 329 MAHQGVSLDRVV--------------PRVGFSMATDSAELFCPPGIRCEKAAFESHVAYV 374 Query 361 PLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDER 420 PLG VE G V AE+LV +L+ +A Q+LRHF +L+ LA PD + + LMD+R Sbjct 375 PLGLTVEVKSGGADVVAEYLVTVLDERMATQLLRHFANVLEAVLADPDRMVGAVDLMDDR 434 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 +A L S GERF+ P TL +LV E+ PDA AVVYEG+H++Y + N+ +NRL HW Sbjct 435 EAQWLWAASSGERFEAPPATLGELVAERAGAQPDAVAVVYEGRHYSYRETNDLANRLAHW 494 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 +IEQGIG+ED VAVLLDKSPDLI+TAL + K+GAVY+P+DP YP DR+ ILAD +LV Sbjct 495 IIEQGIGTEDHVAVLLDKSPDLIITALAIAKAGAVYLPIDPEYPPDRIAHILADAQPRLV 554 Query 541 LRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWF 600 +R PV L + + +P D+DR+RPL PDN AYLIYTSG+TG+PKGV V HRP+ EYF WF Sbjct 555 IREPVTGLDQFDAREPVDSDRVRPLTPDNAAYLIYTSGSTGMPKGVTVTHRPLTEYFNWF 614 Query 601 KGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGI 660 + EY V +DR+LQV SPSFDVSI EIFG L+CG R+VIPRPGGLTD+ YLTALL E + Sbjct 615 RAEYRVGGSDRVLQVGSPSFDVSIGEIFGILSCGGRLVIPRPGGLTDVAYLTALLNSEAV 674 Query 661 TAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTET 720 T+MH VPSLLGL LSLPGV+QW++L+RVP+GGE LPG VADKFHATFDA LHNFYGPTE Sbjct 675 TSMHMVPSLLGLILSLPGVTQWKSLRRVPVGGEALPGPVADKFHATFDASLHNFYGPTEA 734 Query 721 VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHR 780 +INASR+KV G QGTR VPIG PKINT +H+LD++L+PVP G IGEIYI GTH+A GYHR Sbjct 735 IINASRYKVRGIQGTRTVPIGTPKINTQIHILDETLRPVPVGAIGEIYIAGTHLARGYHR 794 Query 781 RAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAA 840 LTA+RF+ADPF PG RMYRSGDLARRNA GD+EFVGRADEQVKIRGFR+ELG++++A Sbjct 795 APALTAQRFIADPFTPGQRMYRSGDLARRNAGGDVEFVGRADEQVKIRGFRVELGEISSA 854 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 I VDP+V QA+VVV +LP LGK LV Y+TP G VD+DRIR+R++AALP+YM+ Sbjct 855 IEVDPSVSQALVVVDELPHLGKRLVAYLTPIGGHV------VDIDRIRSRISAALPDYMI 908 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PAAYVVLDEIPIT HGKIDR ALP P + TE R QT T+R ++ LF ++LG VG Sbjct 909 PAAYVVLDEIPITPHGKIDRDALPAPDSGTVTERREAQTPTQRAVSVLFAQVLGTAVVGI 968 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHID-----TLDSDSA 1015 DDSF LGGHSLLA+KL A + + +GV + +REI TV +LA ID T DS + Sbjct 969 DDSFESLGGHSLLASKLSATILSEYGVRIDIREILRRGTVASLAELIDQHMGSTADSVDS 1028 Query 1016 RPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVV 1075 P + P+ + + N R V LH + A + VV Sbjct 1029 APEGEPI----PLLPGGHSLYEYGNPRRLAVTCVFR------LHDGVNRAALEQLLGAVV 1078 Query 1076 ARHEILRT-VYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETD 1132 HE L + + RE + P A +R A A V D E Sbjct 1079 GEHEALHSRLDRE-----SMTLVPRARPALRFVEIVAADPSVAAAAEIARAVDRLDPEQG 1133 Query 1133 WPIRAALLS-TPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRA 1175 W + A L E VL L VHH+A D S V+ ++L ++A Sbjct 1134 WMLSAVWLHPDNEPGVLILAVHHLAADPISWRVIMSELEARWQA 1177 Score = 85.1 bits (209), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 95/355 (27%), Positives = 149/355 (42%), Gaps = 44/355 (12%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIG 1089 LS+ Q R WF + + N+ + LHG D + AA+ VV RH LRT G Sbjct 29 LSAGQHRIWFAHGVT--PVLMNLCRSYRLHGELDVDKLRAAVAAVVLRHAALRTTVHA-G 85 Query 1090 GVPHQIIQPPAEVPVRCAA------GSDAAWLRAELNNERGY--VFDLETDWPIRAALLS 1141 H + +++ R G A LR + +R Y FDL T+ P+R ++ Sbjct 86 ADGHPVAVLHSDLQARWIEHDVTDLGGTAQELRLAVLAQREYGTAFDLATEAPLRVTVIR 145 Query 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 T + V+ +V H I D S V DL AY + S AP D +V Sbjct 146 TGSAEYVMLVVAHRIGWDDESWQVFLADLTAAYVHGGISEPLSSAPKQGGPGDAAV---- 201 Query 1201 LLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFR-------LGAA 1253 DYW +L A + P P +GA +++ L + Sbjct 202 -------------DYWREELSNPAEPL----ELPGP---NGAVVPTDWKAARCTAHLSVS 241 Query 1254 IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFIN 1313 + +++ ++RD G T +L AA +V+LH+ D + +PV + + IG F N Sbjct 242 VMEQVERLARDSGSTPHAVLLAAYSVLLHRYTHANDFIVASPVPAL-DPHARGRIGHFGN 300 Query 1314 IVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLF 1368 ++ LR R + + +++L R R+ L AHQ + D+VV V + LF Sbjct 301 VLPLRMRPRADESFKDLLARVRRTTLDGMAHQGVSLDRVVPRVGFSMATDSAELF 355 Score = 60.8 bits (146), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 29/73 (40%), Positives = 45/73 (62%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 ++++LD+ L+PVPVG +G++Y G P+ TA RF+ADPF PG R+YR+G+ Sbjct 762 QIHILDETLRPVPVGAIGEIYIAGTHLARGYHRAPALTAQRFIADPFT--PGQRMYRSGD 819 Query 1543 RGVWKADGQLELL 1555 A G +E + Sbjct 820 LARRNAGGDVEFV 832 Score = 40.8 bits (94), Expect = 2.5, Method: Compositional matrix adjust. Identities = 28/88 (32%), Positives = 46/88 (53%), Gaps = 3/88 (3%) Query 1574 ADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA-RDGGIPLTARMVFE 1632 A T T+RA++ + A VL VG D F +LGG S+LA++++A + G+ + R + Sbjct 945 AQTPTQRAVSVLFAQVLGTAVVGIDDSFESLGGHSLLASKLSATILSEYGVRIDIREILR 1004 Query 1633 HPVLCELAAAVDAKPHVEAEPDDKHHAP 1660 + LA +D H+ + D AP Sbjct 1005 RGTVASLAELIDQ--HMGSTADSVDSAP 1030 >gi|118618906|ref|YP_907238.1| non-ribosomal peptide synthetase MbtE [Mycobacterium ulcerans Agy99] gi|118571016|gb|ABL05767.1| non-ribosomal peptide synthetase MbtE [Mycobacterium ulcerans Agy99] Length=1670 Score = 1109 bits (2869), Expect = 0.0, Method: Compositional matrix adjust. Identities = 660/1504 (44%), Positives = 879/1504 (59%), Gaps = 66/1504 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+Q DP LNICV+YR+TG +D RL AVN V RH ILRTTY V +G Sbjct 51 MWFLQTMDPDDVTLNICVAYRLTGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct 111 FSDDVEVGWRREDLTRLPEAGHEQQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSR---ADLGADLGPEHRPSAASGPDTTEADLNYWR 177 LLV HHI WDD SW VFF +L+ AY+ D A ++ P AD+ YW Sbjct 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSV--ADVGYWA 228 Query 178 AIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAF 237 + PEP ELPG +G RA R LPA +RV A+ +P+MVLLAA+ Sbjct 229 ETLRPLPEPPELPGVSGAN--PCRRAQRRVRPLPAGLFSRVEEFARKCSASPFMVLLAAY 286 Query 238 GALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIA 297 G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct 287 GVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETC 346 Query 298 SGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRS 355 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L + Sbjct 347 LAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLGA 405 Query 356 NITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct 406 IAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLAHYLQLVDKALAEPERPLSSLD 464 Query 416 LMD--ERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA--VVYEGQHFTYHDLN 471 ++ ERD+ + S GE + P T+V L+ + ATA +V + TY +L+ Sbjct 465 ILGAGERDSVLAQ--SHGELVEMPATTMVKLLEATASAAGTATALALVSDEAELTYSELH 522 Query 472 EASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFI 531 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D++ Sbjct 523 RRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYL 582 Query 532 LADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGV 586 + D + V+ P ++A SD P +D DR+RPLRP + AY+IYTSG+TG PKGV Sbjct 583 ITDARPQTVIGRPELDVAERAAADNSDLPLSDGDRLRPLRPGHLAYVIYTSGSTGRPKGV 642 Query 587 AVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLT 646 AV H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P Sbjct 643 AVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFG 702 Query 647 DIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHAT 706 DI Y+ L+ G+T +H VPS+L L LP V QWR L+ VP+GGE LPGEVAD+F Sbjct 703 DISYVADLISRRGVTVLHLVPSMLSTLLLLPQVQQWRQLRHVPVGGEALPGEVADRFAGY 762 Query 707 FDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 FDA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP V+GE Sbjct 763 FDAELRNHYGPTEAVVCSTHMLVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVVGE 822 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVK 826 +Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVK Sbjct 823 LYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVK 882 Query 827 IRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDR 886 IRGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ Sbjct 883 IRGFRIELGEVESVITTHPAVRHCLVVAEET-EAGPMLAAYLVPAAA-------QVDLEE 934 Query 887 IRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLA 946 IRA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct 935 IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWIC 994 Query 947 QLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH 1006 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct 995 SIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDVPTPAGLAAR 1054 Query 1007 IDT-------------------LDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPN 1047 + LD ARP + + LS SQ+ +WF YR +G Sbjct 1055 LVERFRNDFELDLDNLAADDMPLDPKQARPGFVKSARPQWLPLSHSQLAAWFQYRIEGAR 1114 Query 1048 AVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPP--AEVPVR 1105 N+P A GP D+ A AAA+ DVVARHE LRT + E GVP+QI+ P ++ VR Sbjct 1115 EEFNMPLALRFEGPLDSVALAAALNDVVARHEALRTNFDEHEGVPYQIVHPSRTVQLAVR 1174 Query 1106 CAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGV 1164 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S + Sbjct 1175 AIDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEI 1231 Query 1165 LFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLA 1224 +F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct 1232 VFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT--ELDYWRDALAGLP 1289 Query 1225 GETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKA 1284 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK Sbjct 1290 DEISVATDRARPRVLGKRGEVVQFSVPAARRSALTQLAERNGATEFMLYQAALAVVLHKL 1349 Query 1285 GGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAH 1344 GGG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AH Sbjct 1350 GGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAH 1409 Query 1345 QDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPT 1400 Q+LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L Sbjct 1410 QELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVN 1465 Query 1401 FDAAQADLSVNFFAC-GDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLRE 1459 F+ A L++ E VI +LYE AT AD L + AFA PD PL Sbjct 1466 FEVALLFLAIGMSVTPSGELDVQVIANADLYEPATVALIADALDAALAAFATTPDLPLSA 1525 Query 1460 VEMV 1463 V+++ Sbjct 1526 VQLL 1529 Score = 124 bits (312), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 131/467 (29%), Positives = 195/467 (42%), Gaps = 49/467 (10%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-RE 1087 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLTGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 Query 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHEQQIESLAADEFGRPFDLTNELPLRITVIR 162 Query 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 Query 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLR--PDFPRPALLSGAGDAVEFR 1249 +L + A YW L G++G R RP Sbjct 212 VLQNSAAPSVADVGYWAETLRPLPEPPELPGVSGANPCRRAQRRVRP------------- 258 Query 1250 LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIG 1309 L A + ++ +R + FM+L AA V++ + G D + PV RS A L G Sbjct 259 LPAGLFSRVEEFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 Query 1310 FFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFD 1369 +F N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D Sbjct 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-D 375 Query 1370 IVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTEL 1429 ++V + M + DG +R L AA LS+ D+ Y+ +L Sbjct 376 LLVRLGFNM-RKSAGGLALDG-VVVRQLGLGAIAAHLPLSLTIALDPDDVSVEFEYQQQL 433 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Q A +L V +A A+ P++PL ++++ A R +L +S+ Sbjct 434 SSVLVDQMLAHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Score = 83.2 bits (204), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 48/115 (42%), Positives = 70/115 (61%), Gaps = 4/115 (3%) Query 1570 PAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARM 1629 P ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P M Sbjct 1551 PVAAGSAETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAM 1610 Query 1630 VFEHPVL---CELAAAVDAKPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 VFEH + A + +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct 1611 VFEHMTIAELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 Score = 64.3 bits (155), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 34/71 (48%), Positives = 43/71 (61%), Gaps = 2/71 (2%) Query 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERG 1544 Y+LD+ L PVP VVG++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct 806 YVLDEQLHPVPDQVVGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Query 1545 VWKADGQLELL 1555 G+LE + Sbjct 864 RRNHCGELEFV 874 Score = 48.5 bits (114), Expect = 0.011, Method: Compositional matrix adjust. Identities = 28/68 (42%), Positives = 40/68 (59%), Gaps = 1/68 (1%) Query 1575 DTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEH 1633 +T TER + +I A + VG D FF LGG S+LA ++ A+ R + G+ LT R +F+ Sbjct 986 ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDV 1045 Query 1634 PVLCELAA 1641 P LAA Sbjct 1046 PTPAGLAA 1053 >gi|183983671|ref|YP_001851962.1| non-ribosomal peptide synthetase MbtE [Mycobacterium marinum M] gi|183176997|gb|ACC42107.1| non-ribosomal peptide synthetase MbtE [Mycobacterium marinum M] Length=1670 Score = 1106 bits (2860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 660/1504 (44%), Positives = 879/1504 (59%), Gaps = 66/1504 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+Q DP LNICV+YR+ G +D RL AVN V RH ILRTTY V +G Sbjct 51 MWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVDTEGEPYQV 110 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 D+ GW + DLT L + ++E LA EF PF+L+ + PLRITV+RT ADE VL Sbjct 111 FSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIRTRADELVL 170 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSR---ADLGADLGPEHRPSAASGPDTTEADLNYWR 177 LLV HHI WDD SW VFF +L+ AY+ D A ++ P AD+ YW Sbjct 171 LLVVHHICWDDDSWEVFFGELSAAYNDLPINDPAAQFLSVEVLQNSAAPSV--ADVGYWA 228 Query 178 AIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAF 237 + PEP ELPG +G RA R LPA +RV A+ +P+MVLLAA+ Sbjct 229 ETLRPLPEPPELPGVSGAN--PCRRAQRRVRPLPAGLFSRVEDFARKCSASPFMVLLAAY 286 Query 238 GALVHRYTHSDDFLVAAPVLNRGAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIA 297 G LV RYT + DFLV+ PV R A+GYFGNT+ +R+ +S +F + R+ Sbjct 287 GVLVRRYTGASDFLVSVPVTERSGAAAGALGYFGNTLLLRITTRSQDTFTSFVNEVRETC 346 Query 298 SGAFAHQRINLDRVVRELNPDR--RHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRS 355 FAHQ + +DRVVRE NP+R R G + + R+ F R+ GG G+ + L + Sbjct 347 LAGFAHQSVGIDRVVREANPERMGRDGMDLLVRLGFNMRK-SAGGLALDGVVVRQLGLGA 405 Query 356 NITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLA 415 LPL + D V VE E+ + L L QML H+ L+D ALA P+ LS L Sbjct 406 VAAHLPLSLTIALDPDDVSVEFEYQQQ-LSSVLVDQMLVHYLQLVDKALAEPERPLSSLD 464 Query 416 LMD--ERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA--VVYEGQHFTYHDLN 471 ++ ERD+ + S GE + P T+V L+ + ATA +V + TY +L+ Sbjct 465 ILGAGERDSVLAQ--SHGELVEMPATTMVKLLEATASAAGTATALALVSDEAELTYSELH 522 Query 472 EASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFI 531 +NRL W I QG G ED + + + S + IV L V+K+GA Y+P+DP+YP +R+D++ Sbjct 523 RRANRLARWFIGQGFGPEDIIGLRMANSIEFIVAMLAVLKAGAAYLPIDPAYPDERIDYL 582 Query 532 LADCDAKLVLRTPVRELA----GYRSDDP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGV 586 + D + V+ P ++A SD P +D+DR+RPLRP + AY+IYTSG+TG PKGV Sbjct 583 ITDARPQTVIGRPELDVAERAAADNSDLPLSDSDRLRPLRPGHLAYVIYTSGSTGRPKGV 642 Query 587 AVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLT 646 AV H +AE+ F E+ + DR LQ +S SFD S+A+IF TL GA++++P+P Sbjct 643 AVSHHAIAEHVQGFVAEWTMTAEDRWLQFSSVSFDASLADIFVTLFLGAQLIVPKPDAFG 702 Query 647 DIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHAT 706 DI Y+ L+ G+T +H VPS+L L LP V QWR L+ VP+GGE LPGEVAD+F Sbjct 703 DISYVADLISRRGVTVLHLVPSMLSTLLLLPQVQQWRQLRHVPVGGEALPGEVADRFAGY 762 Query 707 FDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 FDA L N YGPTE V+ ++ V G G R+VPIG P N ++LD+ L PVP VIGE Sbjct 763 FDAELRNHYGPTEAVVCSTHMVVTGSHGARVVPIGVPNRNVYAYVLDEQLHPVPDQVIGE 822 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVK 826 +Y+GG+ +A GY R LTA+RF+ADPFNPG R+YR+GDL RRN G++EFVGRADEQVK Sbjct 823 LYLGGSQLARGYLGRPTLTAQRFIADPFNPGMRLYRTGDLVRRNHCGELEFVGRADEQVK 882 Query 827 IRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDR 886 IRGFRIELG+V + I P V +VV + G L Y+ PAA VDL+ Sbjct 883 IRGFRIELGEVESVITTHPAVRHCLVVAEET-EAGPMLAAYLVPAAA-------QVDLEE 934 Query 887 IRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLA 946 IRA AAA+PEYM+P A+ V+ EIP+T GK+DR ALP P + +R P+TATER + Sbjct 935 IRAHTAAAVPEYMVPGAFAVIPEIPMTVSGKLDRRALPAPTPIATRRYREPETATERWIC 994 Query 947 QLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGH 1006 +F +L GR RVGA+DSFF LGGHSLLA +LVA +R FGVD+ VR IF+ T LA Sbjct 995 SIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDAPTPAGLAAR 1054 Query 1007 IDT-------------------LDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPN 1047 + LD ARP + + LS SQ+ +WF YR +G Sbjct 1055 LVERFRNDFELDLDNLAADDMPLDPKRARPGFVKSARPQRLPLSHSQLAAWFQYRIEGAR 1114 Query 1048 AVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPP--AEVPVR 1105 N+P A GP D+ A AAA+ DVVARHE LRT + E GVP+QI+ P ++ VR Sbjct 1115 EEFNMPLALRFEGPLDSVALAAALNDVVARHEALRTNFDEHEGVPYQIVHPSRTVQLAVR 1174 Query 1106 CAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGV 1164 + + +L R +VF E+ ++A LL P+ VL L+VHHI DH S + Sbjct 1175 AIDQDEFDDVSTQL---RRHVFTPESGPLLQANLLVLGPDTHVLLLIVHHIVSDHASLEI 1231 Query 1165 LFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLA 1224 +F DL+ AYRAR P W LP+Q+ADY+VWQ + G + DYW L GL Sbjct 1232 VFDDLIVAYRARLQHNAPQWDILPIQFADYAVWQRNTFESNWGQT--ELDYWRDALAGLP 1289 Query 1225 GETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKA 1284 E + D RP +L G+ V+F + AA R L ++ G TEFML QAA+AVVLHK Sbjct 1290 DEISVATDRARPRVLGKRGEVVQFSVPAARRAALTQLAERNGATEFMLYQAALAVVLHKL 1349 Query 1285 GGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAH 1344 GGG D+ +G+PVA R E QL+G F N+VVLR DL G+PTLR +L +R L A AH Sbjct 1350 GGGTDIALGSPVAARVEPATAQLVGLFANVVVLRTDLSGDPTLRSILVGSRDTVLDALAH 1409 Query 1345 QDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ----MPQDHVIDTGPDGDTTLRVLEPT 1400 Q+LP +++VEA+NP R+LSRNPLF +++ R + +P+D TG G+TT+ L Sbjct 1410 QELPIERLVEALNPPRALSRNPLFQNMLNFRGEDWALVPRDL---TG-RGETTVVPLPVN 1465 Query 1401 FDAAQADLSVNFFAC-GDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLRE 1459 F+ A L++ E VI +LYE AT AD L + AFA PD PL Sbjct 1466 FEVALLFLAIGMSVTPSGELDVQVIANADLYEPATVALIADALDAALAAFATTPDLPLSA 1525 Query 1460 VEMV 1463 V+++ Sbjct 1526 VQLL 1529 Score = 122 bits (305), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 130/467 (28%), Positives = 194/467 (42%), Gaps = 49/467 (10%) Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY-RE 1087 RLS Q R WF D + NI A L G D + A+ DVVARH ILRT Y + Sbjct 43 RLSDGQRRMWFLQTMDPDDVTLNICVAYRLAGLVDEDRLHTAVNDVVARHAILRTTYGVD 102 Query 1088 IGGVPHQIIQPPAEVP------VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS 1141 G P+Q+ EV R + + +E G FDL + P+R ++ Sbjct 103 TEGEPYQVFSDDVEVGWRREDLTRLPEAGHERQIESLAADEFGRPFDLTNELPLRITVIR 162 Query 1142 T-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 T ++ VL LVVHHI D S V F +L AY LP+ Sbjct 163 TRADELVLLLVVHHICWDDDSWEVFFGELSAAYN-----------DLPINDPAAQFLSVE 211 Query 1201 LLDDGAGIVGPQRDYWIRQL---------GGLAGETGLR--PDFPRPALLSGAGDAVEFR 1249 +L + A YW L G++G R RP Sbjct 212 VLQNSAAPSVADVGYWAETLRPLPEPPELPGVSGANPCRRAQRRVRP------------- 258 Query 1250 LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIG 1309 L A + ++ +R + FM+L AA V++ + G D + PV RS A L G Sbjct 259 LPAGLFSRVEDFARKCSASPFMVLLAAYGVLVRRYTGASDFLVSVPVTERSGAAAGAL-G 317 Query 1310 FFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFD 1369 +F N ++LR R T + R+ LA +AHQ + D+VV NP+R + R+ + D Sbjct 318 YFGNTLLLRITTRSQDTFTSFVNEVRETCLAGFAHQSVGIDRVVREANPER-MGRDGM-D 375 Query 1370 IVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTEL 1429 ++V + M + DG +R L AA LS+ D+ Y+ +L Sbjct 376 LLVRLGFNM-RKSAGGLALDG-VVVRQLGLGAVAAHLPLSLTIALDPDDVSVEFEYQQQL 433 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Q +L V +A A+ P++PL ++++ A R +L +S+ Sbjct 434 SSVLVDQMLVHYLQLVDKALAE-PERPLSSLDILGAGERDSVLAQSH 479 Score = 82.0 bits (201), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 47/108 (44%), Positives = 69/108 (64%), Gaps = 4/108 (3%) Query 1577 ETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPVL 1636 ETER L A+L ++LE+ + R +++F LGGDSI+A + +A+A G+P MVFEH + Sbjct 1558 ETERRLTAMLEELLEITGIDRDENYFALGGDSIIAIKWSAQAGALGLPFPPAMVFEHMTI 1617 Query 1637 ---CELAAAVDAKPHVEAEPDD-KHHAPMSTSGLSPDELSALTASWDQ 1680 A + +P VEA+P + + PMS SGL+PD L+ L+ASW Q Sbjct 1618 AELAAAVDAANGEPVVEADPPPAQEYTPMSASGLAPDALAKLSASWLQ 1665 Score = 63.9 bits (154), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 33/71 (47%), Positives = 43/71 (61%), Gaps = 2/71 (2%) Query 1485 YLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERG 1544 Y+LD+ L PVP V+G++Y GG L RP+ TA RF+ADPF PG RLYR G+ Sbjct 806 YVLDEQLHPVPDQVIGELYLGGSQLARGYLGRPTLTAQRFIADPF--NPGMRLYRTGDLV 863 Query 1545 VWKADGQLELL 1555 G+LE + Sbjct 864 RRNHCGELEFV 874 Score = 48.9 bits (115), Expect = 0.008, Method: Compositional matrix adjust. Identities = 28/68 (42%), Positives = 40/68 (59%), Gaps = 1/68 (1%) Query 1575 DTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEH 1633 +T TER + +I A + VG D FF LGG S+LA ++ A+ R + G+ LT R +F+ Sbjct 986 ETATERWICSIFAQLFGRQRVGAEDSFFGLGGHSLLAARLVAQIRAEFGVDLTVRTIFDA 1045 Query 1634 PVLCELAA 1641 P LAA Sbjct 1046 PTPAGLAA 1053 >gi|302526154|ref|ZP_07278496.1| hypothetical protein SSMG_02536 [Streptomyces sp. AA4] gi|302435049|gb|EFL06865.1| hypothetical protein SSMG_02536 [Streptomyces sp. AA4] Length=2362 Score = 920 bits (2379), Expect = 0.0, Method: Compositional matrix adjust. Identities = 583/1483 (40%), Positives = 796/1483 (54%), Gaps = 83/1483 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+Q +P A N+C++ + GD+D L+ + + RH ILRT Y G DG + Sbjct 45 MWFLQQLEPGTAAYNVCLAIDLRGDLDRPALQRSFQRLVERHEILRTRYLPGADGEPRQV 104 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V + DL L + +E A+ E F+L+++ LR+ ++R A +++VL Sbjct 105 VDPFAVVTMAETDLRGLPADRRDAAVESSAREESAHGFDLAKEHSLRLKLLRRADNDYVL 164 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASG----------PDTTE 170 +L HHIAWD ++ DL+ Y G G E P + D Sbjct 165 VLTVHHIAWDGFTFNALSHDLSALYREDTTGRPAGLEPLPVQYADFALWQRKTFTDDRLA 224 Query 171 ADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPY 230 DL+YWRA + PE L LP S R R D RV A + G TP+ Sbjct 225 KDLDYWRAALDPMPESLPLPTDFPRPATRSSRGDRRMRTFGTDVTERVTAFAHDRGVTPF 284 Query 231 MVLLAAFGALVHRYTHSDDFLVAAPVLNRGAG-TEDAIGYFGNTVAMRLRPQSAMSFREL 289 MV+ AA+ AL+HRYT + D + + +NR AG E +G FGNT+ +R SF +L Sbjct 285 MVVFAAYAALLHRYTGATDVPIGSASMNRDAGEVERLVGNFGNTLVLRADLSGQPSFADL 344 Query 290 LTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECE 349 ++ + + + +AHQ + D +V +L P R G + V F GF+ PGIE Sbjct 345 VSRVQRVCTDGYAHQDLPFDVLVEKLRPPRTAGRSVLFDVMLLFLAQGLRGFDFPGIETA 404 Query 350 RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDN 409 + ++ TQ L + +EA + ++ + L H LL +ALAAPD Sbjct 405 WRTVHNDTTQFDLALEAFLAGGRMRIEATYSTDLYAAPTIDRFLDHLESLLRHALAAPDT 464 Query 410 TLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHD 469 ++ LA E+ G + P TL +L Q RTPDA AV + TY + Sbjct 465 PVARLAYHSA-------EIPAGRSAEAPETTLAELFASQAARTPDAEAVRFGSDSLTYAE 517 Query 470 LNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLD 529 L+ + L L G+G E V + D+S DLIV+ L V K+G Y+P+DPSYP DRL+ Sbjct 518 LDAKAAGLAGQLAAAGVGPERIVGIRQDRSLDLIVSLLAVHKAGGAYLPLDPSYPADRLE 577 Query 530 FILADCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVP 589 F++ D +VL P+ ++ P PDN AY+IYTSG+TG PKGV V Sbjct 578 FMIEDAQPAVVLPCPLE-----------NSVETTPASPDNAAYVIYTSGSTGRPKGVVVT 626 Query 590 HRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIG 649 HR + W + EY + DR+LQ SFDVS+ E F L GA +V+ +PGG D Sbjct 627 HRAIVNRLRWMQHEYHLTADDRVLQKTPSSFDVSVWEFFWPLIAGATLVLAKPGGHKDPD 686 Query 650 YLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDA 709 YL L+ E IT +HFVPS+L + P +RV GE LP ++A Sbjct 687 YLAELITRERITTVHFVPSMLRAYGDRP------LPKRVITSGEALPSDLALP------- 733 Query 710 LLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYI 769 LHN YGPTET ++ + + V GT IVPIGRP NT +H+LD +LQPVP GV GE+Y+ Sbjct 734 QLHNLYGPTETAVDVTYWPAVEGAGTGIVPIGRPVWNTRLHVLDSALQPVPPGVEGELYL 793 Query 770 GGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRG 829 G +A GY R LTA RFVA P G R+YR+GDL R ADG +EFVGRAD+QVK+RG Sbjct 794 AGVQLARGYLNRPALTASRFVAAP--NGQRLYRTGDLVRWRADGVVEFVGRADDQVKLRG 851 Query 830 FRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRA 889 FRIELG+V AA+ P + A VV+ P + LV Y+ A G R Sbjct 852 FRIELGEVEAALTALPRITGAAVVLR--PE-QQQLVAYIVGDATG------------ARH 896 Query 890 RVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIA-SDTEFRAPQTATERRLAQL 948 +A LP++++P+ V LDE+P++ GK+DR ALP P A +D E P T ER LA L Sbjct 897 ALAKTLPDHLIPSVVVELDELPLSPSGKLDRRALPAPTSAVTDDE---PGTERERALAML 953 Query 949 FGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHID 1008 F +LLG DRVG D FF LGGHSLLATKLV R G ++ + +F+ TV LA +D Sbjct 954 FADLLGLDRVGVHDDFFALGGHSLLATKLVGRARAELGAELTIGTVFDAPTVARLAAILD 1013 Query 1009 TLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFA 1068 D RP LT + + LS +Q R WF YR +G +A N+PFA L G D +A Sbjct 1014 --DRGKTRPALTPMTRPRRLPLSFAQQRLWFLYRLEGASATYNVPFAVRLDGQLDVDALR 1071 Query 1069 AAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFD 1128 AA++DVV RHE+LRT+Y E G P+Q Q P G+ + F+ Sbjct 1072 AALSDVVGRHEVLRTIYPEFEGKPYQ--QVLGWTPTLAIGGT--------VREAAQRAFE 1121 Query 1129 LETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLP 1188 L+ + P A L+ + VLSL+ HHIA D WS L DL TAY AR G+RP+W PLP Sbjct 1122 LDREPPFEARLIRDGDSHVLSLLTHHIASDGWSTERLVADLTTAYAARCAGRRPAWTPLP 1181 Query 1189 VQYADYSVWQSALLDDGA---GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 V YADY +WQ LL + A + Q +YW L L E L D PRPA S AGDA Sbjct 1182 VHYADYVLWQRDLLGNDADPDSLASTQLEYWRTALADLPEELPLPTDRPRPATASFAGDA 1241 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 V F+L A R L ++R+ G T FM +QAA A +L G G D+PIG+PVAGR++A LD Sbjct 1242 VRFQLSAETRAALHKLARETGSTVFMTVQAAFAALLGALGAGDDIPIGSPVAGRTDAALD 1301 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 L+GFF+N +VLR DL G+PT R+++ R R+ L A+AHQDLPF+++VEAVNP RSL ++ Sbjct 1302 SLVGFFVNTLVLRTDLTGDPTFRQLVDRVRRTDLDAFAHQDLPFERIVEAVNPARSLGKH 1361 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIY 1425 PLF ++ Q +T P G+ LR F AA+ DLS + F G ++Y Sbjct 1362 PLFQVMFAY-----QQAAAETAPFGEAALREEHVGFYAARTDLSCHLFEHAGGIDGWLVY 1416 Query 1426 RTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQAR 1468 +L++++T A VR E+ PD+PL +++ R Sbjct 1417 SRDLFDQSTVDDMATRFVRYTESLVTEPDRPLSATTVLTEGER 1459 Score = 495 bits (1274), Expect = 4e-137, Method: Compositional matrix adjust. Identities = 364/1039 (36%), Positives = 518/1039 (50%), Gaps = 122/1039 (11%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + + A N+ + R+ G +D+ LR A++ V RH +LRT YP + Q Sbjct 1040 LWFLYRLEGASATYNVPFAVRLDGQLDVDALRAALSDVVGRHEVLRTIYPEFEGKPYQQV 1099 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + GWT + R AQR F EL R+ P ++R D HVL Sbjct 1100 L------GWTPTLAIGGTVREA-------AQRAF----ELDREPPFEARLIRDG-DSHVL 1141 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYS------------------------RADLGADLGP 156 L+ HHIA D S DLT AY+ R LG D P Sbjct 1142 SLLTHHIASDGWSTERLVADLTTAYAARCAGRRPAWTPLPVHYADYVLWQRDLLGNDADP 1201 Query 157 EHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAA 216 + S L YWR +AD PE L LP S+ +L A+T A Sbjct 1202 DSLAST---------QLEYWRTALADLPEELPLPTDRPRPATASFAGDAVRFQLSAETRA 1252 Query 217 RVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNR-GAGTEDAIGYFGNTVA 275 + +A+ TG T +M + AAF AL+ DD + +PV R A + +G+F NT+ Sbjct 1253 ALHKLARETGSTVFMTVQAAFAALLGALGAGDDIPIGSPVAGRTDAALDSLVGFFVNTLV 1312 Query 276 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFRE 335 +R +FR+L+ R AFAHQ + +R+V +NP R G + +V F +++ Sbjct 1313 LRTDLTGDPTFRQLVDRVRRTDLDAFAHQDLPFERIVEAVNPARSLGKHPLFQVMFAYQQ 1372 Query 336 P--DGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAG----VLVEAEHLVEILEPALA 389 + F + E + T L F+ AG LV + ++ + + Sbjct 1373 AAAETAPFGEAALREEHVGFYAARTDLSCHL---FEHAGGIDGWLVYSR---DLFDQSTV 1426 Query 390 KQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQT 449 M F ++ + PD LS ++ E R+ E E P TL +L Q Sbjct 1427 DDMATRFVRYTESLVTEPDRPLSATTVLTE--GERVLEFPAAE---VPETTLAELFAAQV 1481 Query 450 TRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGV 509 +RTPDA AV + TY L+ + L L G+G + V + D+S DL+V+ L V Sbjct 1482 SRTPDAEAVRFGRDSLTYAQLDARATDLAEQLSAAGVGPDQIVGIRQDRSLDLVVSLLAV 1541 Query 510 VKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDPTDADRIRPLRPDN 569 +K+G Y+P+DPSYP +RLDF++ D VL + A +P A +PD+ Sbjct 1542 LKAGGAYLPLDPSYPAERLDFMIEDAQPVAVLPAALEGRA-----EPAGA------KPDD 1590 Query 570 TAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFG 629 AY+IYTSG+TG PKGV V HR + +W + Y + DR+LQ SFDVS+ E F Sbjct 1591 AAYVIYTSGSTGRPKGVVVSHRSIVNRLLWMQDRYGLTADDRVLQKTPSSFDVSVWEFFW 1650 Query 630 TLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVP 689 L GA +V+ +P G D YL L++ E IT +HFVPS+L + P +RV Sbjct 1651 PLITGATLVLAKPDGHKDPDYLAHLIQTEDITTVHFVPSMLRAYGDRP------LPERVI 1704 Query 690 IGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTM 749 GE LP ++A +HN YGPTET ++ + V T V IGRP NT Sbjct 1705 TSGEALPADIAKPG-------MHNLYGPTETAVDVTHHTV-----TDQVAIGRPVWNTQT 1752 Query 750 HLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARR 809 H+LD L+PVP GV GE+Y+GG +A GY R LTA RFVA P G R+YR+GDL +R Sbjct 1753 HVLDRLLRPVPPGVPGELYLGGVQLARGYLNRPALTASRFVAAP--NGQRLYRTGDLVKR 1810 Query 810 NADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVT 869 + +G + ++GR D+QVK+RGFRIELG++ AA+A + V A VVV D + LV YV Sbjct 1811 DREGVLHYLGRTDDQVKLRGFRIELGEIEAALAAEDGVDVAAVVVRD-----ERLVAYV- 1864 Query 870 PAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIA 929 VG D + A LPE+++PAA V LD +P+T++GK++R ALP+P Sbjct 1865 ----------VGTAPD-----LRAKLPEHLVPAAIVELDRLPLTSNGKLNRKALPDPDFT 1909 Query 930 SDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDV 989 + T P+T ER L QLF E L +G DSFF+LGG S+++ +LV+ R A G+ + Sbjct 1910 ARTGSAKPRTERERLLCQLFAETLQLPEIGVHDSFFELGGDSIVSVQLVSRARKA-GISL 1968 Query 990 GVREIFEFATVTALAGHID 1008 R++FE T LA D Sbjct 1969 TPRQVFEHRTPAGLAAAGD 1987 Score = 225 bits (573), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 155/457 (34%), Positives = 224/457 (50%), Gaps = 15/457 (3%) Query 1018 RLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVAR 1077 ++ + D + + LSS+Q R WF + + A N+ A L G D A + +V R Sbjct 26 QIPKRDREDDLPLSSAQSRMWFLQQLEPGTAAYNVCLAIDLRGDLDRPALQRSFQRLVER 85 Query 1078 HEILRTVYRE-IGGVPHQIIQP-----PAEVPVR-CAAGSDAAWLRAELNNERGYVFDLE 1130 HEILRT Y G P Q++ P AE +R A A + + E + FDL Sbjct 86 HEILRTRYLPGADGEPRQVVDPFAVVTMAETDLRGLPADRRDAAVESSAREESAHGFDLA 145 Query 1131 TDWPIRAALLSTPEQT-VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + +R LL + VL L VHHIA D ++ L DL YR +TG+ PLPV Sbjct 146 KEHSLRLKLLRRADNDYVLVLTVHHIAWDGFTFNALSHDLSALYREDTTGRPAGLEPLPV 205 Query 1190 QYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFR 1249 QYAD+++WQ D + DYW L + L DFPRPA S GD Sbjct 206 QYADFALWQRKTFTDDR--LAKDLDYWRAALDPMPESLPLPTDFPRPATRSSRGDRRMRT 263 Query 1250 LGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIG 1309 G + +++ A + D GVT FM++ AA A +LH+ G DVPIG+ R +++L+G Sbjct 264 FGTDVTERVTAFAHDRGVTPFMVVFAAYAALLHRYTGATDVPIGSASMNRDAGEVERLVG 323 Query 1310 FFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFD 1369 F N +VLR DL G P+ +++ R +++ YAHQDLPFD +VE + P R+ R+ LFD Sbjct 324 NFGNTLVLRADLSGQPSFADLVSRVQRVCTDGYAHQDLPFDVLVEKLRPPRTAGRSVLFD 383 Query 1370 IVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTEL 1429 +++ Q + P +T R + D Q DL++ F G R Y T+L Sbjct 384 VMLLFLAQGLRGFDF---PGIETAWRTVHN--DTTQFDLALEAFLAGGRMRIEATYSTDL 438 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQ 1466 Y T RF D L ++ PD P+ + SA+ Sbjct 439 YAAPTIDRFLDHLESLLRHALAAPDTPVARLAYHSAE 475 Score = 72.8 bits (177), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 37/75 (50%), Positives = 48/75 (64%), Gaps = 0/75 (0%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPV 1635 TE ER L + A+ L++ E+G +D FF LGGDSI++ Q+ +RAR GI LT R VFEH Sbjct 1919 TERERLLCQLFAETLQLPEIGVHDSFFELGGDSIVSVQLVSRARKAGISLTPRQVFEHRT 1978 Query 1636 LCELAAAVDAKPHVE 1650 LAAA D H + Sbjct 1979 PAGLAAAGDFTVHAD 1993 Score = 65.1 bits (157), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/87 (48%), Positives = 54/87 (63%), Gaps = 2/87 (2%) Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR- 1619 LP +A EP TE ERALA + AD+L + VG +DDFF LGG S+LAT++ RAR Sbjct 930 LPAPTSAVTDDEPG-TERERALAMLFADLLGLDRVGVHDDFFALGGHSLLATKLVGRARA 988 Query 1620 DGGIPLTARMVFEHPVLCELAAAVDAK 1646 + G LT VF+ P + LAA +D + Sbjct 989 ELGAELTIGTVFDAPTVARLAAILDDR 1015 Score = 62.4 bits (150), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 34/73 (47%), Positives = 46/73 (64%), Gaps = 4/73 (5%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R+++LD AL+PVP GV G++Y G L RP+ TA+RFVA P G RLYR G+ Sbjct 772 RLHVLDSALQPVPPGVEGELYLAGVQLARGYLNRPALTASRFVAAP----NGQRLYRTGD 827 Query 1543 RGVWKADGQLELL 1555 W+ADG +E + Sbjct 828 LVRWRADGVVEFV 840 Score = 50.4 bits (119), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/77 (41%), Positives = 42/77 (55%), Gaps = 4/77 (5%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 + ++LD L+PVP GV G++Y GG L RP+ TA+RFVA P G RLYR G+ Sbjct 1751 QTHVLDRLLRPVPPGVPGELYLGGVQLARGYLNRPALTASRFVAAP----NGQRLYRTGD 1806 Query 1543 RGVWKADGQLELLAEIE 1559 +G L L + Sbjct 1807 LVKRDREGVLHYLGRTD 1823 >gi|291443461|ref|ZP_06582851.1| nonribosomal peptide synthetase [Streptomyces roseosporus NRRL 15998] gi|291346408|gb|EFE73312.1| nonribosomal peptide synthetase [Streptomyces roseosporus NRRL 15998] Length=6082 Score = 887 bits (2293), Expect = 0.0, Method: Compositional matrix adjust. Identities = 629/1708 (37%), Positives = 893/1708 (53%), Gaps = 141/1708 (8%) Query 30 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 89 R +A+ +V RH ILRT + D + +P V LR + DL L +L Sbjct 2190 RFLEALQSVVDRHDILRTGFAWED--LREP-VQVVLRHAEIPVNEVDLGGFEGDLAQGLL 2246 Query 90 AQREFCAPFELSRDAPL-RITVV-RTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSR 147 A C+P R APL R TV D +L L HH+ D + V ++ R Sbjct 2247 A---LCSPSLDIRQAPLLRATVAAEPGGDRWLLALQVHHLVQDHTALAVLLGEV-----R 2298 Query 148 ADLGADLGP--------EHRPSAASGPDTTEADLNYWRAI--MADPPEPLELPGPAGTCV 197 LG D G E A G E + + + +++P P L G Sbjct 2299 TLLGGDAGALPVPVPFREFVAQARLGVSRAEHERFFGELLSGVSEPTAPFGLLDVHGDGS 2358 Query 198 PTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVL 257 + AT L AD AAR+ A+ +P + + + + DD + + + Sbjct 2359 DVT----EATAVLDADLAARLREQARRLSVSPATLFHLVWARVAAVTSGRDDVVFGSVLF 2414 Query 258 NR---GAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRE 314 R G G + G F NT+ +R+ P + E + + + H+ L +V + Sbjct 2415 GRMQAGTGADRTPGLFINTLPVRV-PTGRVPVGEAVRGMQKQLADLLVHEHAPL--MVAQ 2471 Query 315 LNPDRRHGAERMTRV---SFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRA 371 D T + R + + G + R+N PL V+ Sbjct 2472 QAADLAAETPLFTSLLNYRHNERPREQMSLDLAGADIVYTRERTN---YPLTVSVDDTGE 2528 Query 372 GVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLAL-----MDERDAARLR 426 G + V+ P A+ + G + + A ++ + LAL + E + RL Sbjct 2529 GFGLT----VQASAPIAAESVCGLVGAAAEGLVTALEDEAASLALHRIPVLGEVERDRLV 2584 Query 427 EVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGI 486 P +L +L+ Q RTP+ATAVV+EG ++Y +L+ +NRL LI +G+ Sbjct 2585 WGWNDTDRSVPQVSLTELLAAQAVRTPEATAVVFEGVGWSYAELDARANRLARLLIARGV 2644 Query 487 GSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVR 546 G E VAV +++S DL+V L V+K+G YVP+DP YP DR+ ++L D LV+ + Sbjct 2645 GPESLVAVCMERSADLVVALLAVLKAGGAYVPIDPEYPADRIAYVLEDAQPALVVTSRAT 2704 Query 547 ELAGYRSDD------PTDADRIRPLR-------------PDNTAYLIYTSGTTGLPKGVA 587 E A D AD + L+ P + AY+IYTSG+TG PKGVA Sbjct 2705 EGAVPEGADIPARVQVDGADVLAQLKALSGEPVSSVEVLPSHVAYVIYTSGSTGRPKGVA 2764 Query 588 VPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTD 647 VPH+ V +W + + +D +DR++Q FDVS+ E F L GA +V+ RPGG D Sbjct 2765 VPHQGVVNRLLWMQDTFPLDGSDRVVQKTPFGFDVSVWEFFWPLITGAGLVVARPGGHRD 2824 Query 648 IGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF 707 GYLT L+R E +T HFVPS+L +FL P + L+ V GE LP E+ D+F Sbjct 2825 AGYLTELIRHEKVTVAHFVPSMLRVFLREPDAAACTGLRWVVCSGEALPPELRDQFFDVL 2884 Query 708 -DALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGE 766 D LHN YGPTE ++ + + +G VPIG P NT ++LD L PVP GV G+ Sbjct 2885 EDVELHNLYGPTEASVDVTAWPCTPDEGP-AVPIGHPVWNTRTYVLDTGLHPVPVGVAGD 2943 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPF-NPGSRMYRSGDLARRNADGDIEFVGRADEQV 825 +Y+ G +A GY R GLTAERFVA+PF G RMYR+GD+ R DG++EF+GRAD+QV Sbjct 2944 LYLAGDQLARGYLGRPGLTAERFVANPFGTTGERMYRTGDVVRWRTDGNLEFLGRADDQV 3003 Query 826 KIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLD 885 K+RGFRIELG++ AA+ V QA V+V + K LV YV PA G VD Sbjct 3004 KVRGFRIELGEIEAALMSHAAVAQAAVLVREDVPGDKRLVAYVVPAVPGGT-----VDTT 3058 Query 886 RIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRL 945 +RA V + LPEYM+P+A VVLD +P+T +GK+DR ALP P+ A+ + RAP A E L Sbjct 3059 TLRAYVGSRLPEYMVPSATVVLDTLPVTVNGKLDRRALPAPEYAAASGGRAPANAQEEIL 3118 Query 946 AQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAG 1005 +F ++LG V DD+FF+LGGHSLLA +LV+ VR GV+ GVR +FE TV LA Sbjct 3119 CSVFADVLGVPHVAVDDNFFELGGHSLLAVRLVSRVRTVLGVETGVRTVFEAPTVELLAK 3178 Query 1006 HIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTN 1065 ++ ++D ARP L+ PV LS +Q R WF +GPNA NIP A LHG DT Sbjct 3179 RLE--NADEARPALSARTRPEPVPLSFAQQRLWFLGELEGPNATYNIPAAIHLHGTLDTQ 3236 Query 1066 AFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGY 1125 A +AA+ DVVARHE+LRTV+ + G P Q I P + RC + EL+ + Sbjct 3237 ALSAALNDVVARHEVLRTVFPMVDGQPQQRILDPDQA--RCELTT------MELSPQNAE 3288 Query 1126 ---------VFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRA 1175 VFDL TD P+RA L +T + +L LV+HH+AGD WS L D+ AY A Sbjct 3289 EAMAEAAAGVFDLATDLPLRAWLFTTGTNEHILMLVLHHVAGDGWSMAPLAHDVSLAYTA 3348 Query 1176 RSTGQRPSWAPLPVQYADYSVWQSALLDDGA---GIVGPQRDYWIRQLGGLAGETGLRPD 1232 +T P+W PLPVQYADY++WQ LL D ++ Q YW + L + E L D Sbjct 3349 HTTSSTPTWEPLPVQYADYTLWQRELLGDETDPHSLMAQQLAYWRQALADIPDELALPLD 3408 Query 1233 FPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPI 1292 PRPA+ + G V+ + I +L +R GVT FM+LQAA A +L++ G G D+P+ Sbjct 3409 RPRPAIATHQGGIVDLTIEPDIHTRLLHTARTHGVTLFMVLQAATAALLNRLGAGRDIPL 3468 Query 1293 GAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQV 1352 G PVAGRS+ L+ L+GFF+N +V+R DL +P+ ++L++ R+ LAA+ H D+PF+++ Sbjct 3469 GVPVAGRSDEALENLVGFFVNTLVIRTDLTADPSFTQLLEQVRETGLAAHTHADIPFERL 3528 Query 1353 VEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT-GPDGDTTLRVLEPTFDAAQADLSVN 1411 VE + P RS++R+PLF I++ + D V+D G D + V+ AA+ DL +N Sbjct 3529 VEELAPTRSMARHPLFQIMLSLDTH--ADAVVDLPGLDAE----VIASKDSAAKFDLDLN 3582 Query 1412 ----FFACGDE--YRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 F A G RG V+Y +L++ AT + VRV+EA P QP+ + ++ Sbjct 3583 VRERFDASGAPAGLRGTVVYAVDLFDEATVAELVERFVRVLEAVTADPHQPVSRIRILGD 3642 Query 1466 QARRRILDR---------------------SNAGAGTARVYLLDDALKPVPVGVVGDVYY 1504 RIL S A AG +V++LD AL+PVPVGV GD+Y Sbjct 3643 AELDRILTEWKGCATGIPARTVPVLEAAPPSGADAG-GKVFVLDAALQPVPVGVTGDLYV 3701 Query 1505 GGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELL--AEIERLP 1562 GG RP TA RFVA PF G R+YR G+ +ADG LEL+ A ER P Sbjct 3702 AGGLTDRGYEGRPGLTAERFVACPFEGA-GERMYRTGDVVRRRADGSLELVGSAHEEREP 3760 Query 1563 TAQAAPVPAEPA-----DTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR 1617 A A + A + E L+++ A++L++ +VG D+FF LGG S++A ++ R Sbjct 3761 NASTAVGEGQSARRRGPSSVQEEILSSVFAEMLDLPQVGVDDNFFELGGHSLMAVKLVVR 3820 Query 1618 ARDGGIPLTARMVFEHPVLCELAAAVDA 1645 R+ G+P++ R +F P + LAAAV A Sbjct 3821 LRELGMPVSVRSLFATPTVAGLAAAVSA 3848 Score = 427 bits (1098), Expect = 8e-117, Method: Compositional matrix adjust. Identities = 427/1465 (30%), Positives = 658/1465 (45%), Gaps = 154/1465 (10%) Query 22 ITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRA 81 I G++D+ A+ + R + T + + V Q H + W + + + Sbjct 3 INGELDVDLFERALRSAVREAEAVHTRFVGEGEAVRQ---HVRVSDDWPFHRIDLSGEPD 59 Query 82 QRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDL 141 R R E + + P ++ DA ++R D HHI D S + + Sbjct 60 PRARAEEWMRTDMRRPVDMRGDALFTQAMLRLGPDHVYWYQRCHHILGDGFSGPLVNNRI 119 Query 142 TQAYS--RADLGADLGPEHRPS-------AASGPDTTEADLNYWRAIMADPPEPLELPG- 191 Q Y+ RA D G S A G + D YW I AD P P+ L G Sbjct 120 AQIYAALRAGDAYDEGALAPFSNLLDADRAYRGSEEQAKDRAYWGEIFADLPTPVSLSGR 179 Query 192 -PAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDF 250 PAGT R T +P++ AA + T A++ + + +AA ++R T ++D Sbjct 180 IPAGT----PHHLIRGTAEMPSEAAADLRTTARSLRTSISGMAIAAAAVYLNRATGAEDV 235 Query 251 LVAAPVLNR-GAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLD 309 +VA PV R G+ G N + +RL +S+M+ +EL+ GA HQ+ + Sbjct 236 VVALPVFGRFGSAQRQTPGMATNLLPIRLTVRSSMTVQELVRQVSVQVRGALRHQKYRYE 295 Query 310 RVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFD 369 ++R+L R M P F+ E + L S + F V +D Sbjct 296 DMLRDLRLIGRGNLASMVVNVV----PYAYDFSFGDCEVRAHALSSGHFN-DVAFCV-YD 349 Query 370 RAG---VLVEAEHLVEILEP-ALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARL 425 R+ + + + E+ P A + R VL A AAP++ + + ++DE + ++ Sbjct 350 RSADGRIQIATDASPELYSPHANQRHTDRLHTVLTWLATAAPEDRVGRVEILDEAERRQV 409 Query 426 REVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQG 485 + P TL L+ EQ T TP AV +G +Y +L+ ++NRL L+ +G Sbjct 410 LQDWNDTDRPVPATTLTQLLEEQATHTPGKPAVSSQGVDRSYAELHASANRLARLLVSRG 469 Query 486 IGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT-- 543 +G E VAV +++S DL+V L V+K+G YVPVDP YP DR+ +L D LVL + Sbjct 470 VGPESLVAVSMERSVDLVVALLAVLKAGGAYVPVDPEYPADRIAHMLEDARPVLVLTSEA 529 Query 544 ---PVRELAGYRS---DDP--------------TDADRIRPLRPDNTAYLIYTSGTTGLP 583 + ++AG D+P T ++R P P + AY+IYTSG+TG P Sbjct 530 VAPSLPDVAGLERVVIDEPGVGAALNGLGTAALTASERRGPQLPSHPAYVIYTSGSTGRP 589 Query 584 KGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPG 643 KGV + H+ + Y Y LL AS SFD + ++G L CG R+++ Sbjct 590 KGVLITHQNLVNYVSRCTEAYPDLHGTTLLH-ASISFDAGVTALYGALTCGGRVIVEPMD 648 Query 644 GLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPG-EVADK 702 +L A LR + + PS L +L S T Q + +GGE + G ++ D Sbjct 649 E-----HLPATLRTHELAFLKATPSHL-TYLDGFDESCAPTGQLM-VGGEAVGGTQIRDW 701 Query 703 FHATFDALLHNFYGPTETVINASRFKVVGPQGTRI--VPIGRPKINTTMHLLDDSLQPVP 760 + N YGPTE + + + V T +PIGRP NT +++LD +L+PVP Sbjct 702 RRRHPSVAVVNHYGPTEVTVGCTDYVVTADDDTETATLPIGRPMWNTRVYVLDAALRPVP 761 Query 761 TGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NPGSRMYRSGDLARRNADGDIEFVG 819 GV GE+Y+ G +A GY R GL+AERF+A PF G RMYR+GD+ R DG++EF+G Sbjct 762 AGVPGELYVAGDQLARGYLGRPGLSAERFIACPFGTAGERMYRTGDVVRWRTDGNLEFLG 821 Query 820 RADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPAD 879 RAD+QVKIRG+RIELG++ +A+ V +A V+V + K LV YV P GD Sbjct 822 RADDQVKIRGYRIELGEIESALESHGDVSRAAVLVREDVPGDKRLVAYVVPTVSGDTLD- 880 Query 880 VGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQT 939 VD +R + LPEYM+P+A VVL+ +P+T +GK+DR ALP P+ + RAP + Sbjct 881 -AVDTAALRGHLGRVLPEYMVPSATVVLEALPLTVNGKLDRRALPAPEYTAAGGGRAPAS 939 Query 940 ATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLV---------AAVRNAF----- 985 E L +F E+LG VG DD+FF+LGGHSLLA L+ +VR+ F Sbjct 940 LQEEILCAVFAEVLGVPAVGVDDNFFELGGHSLLAVSLIELLRERGMSVSVRDLFAAPTA 999 Query 986 ----------------------GVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVD 1023 G + E+ +TA + ++ SAR + + Sbjct 1000 AGLAAASAGAGSVTVPENLIPAGAETITPEMLPLVDLTA-----EEIERISARVQGGAAN 1054 Query 1024 HDGPVRLSSSQMRSWFNYRFDGPNA--VNNIPFAAALHGPCDTNAFAAAITDVVARHEIL 1081 L+ Q +F+ G + V +P F A+ VV RH+IL Sbjct 1055 IADIYPLAPLQEGIFFHSVLGGDSGADVYVLPTVLGFDTRDRAERFLEALQSVVDRHDIL 1114 Query 1082 RTVYREIG-GVPHQIIQPPAEVPVRCAA-----GSDAAWLRAELNNERGYVFDLETDWPI 1135 RT + G P Q++ A +PV +D EL + D+ + Sbjct 1115 RTGFAWEGLREPVQVVLREATLPVEELQLAPRPDTDPVQQFLELCSPS---LDIRQAPLL 1171 Query 1136 RAALLSTP--EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYAD 1193 RA + + P ++ +++L HH+ DH + +L ++ T G P+PV + + Sbjct 1172 RATVAAEPGGDRWLVALQAHHLVRDHTTLEILLGEVRTLL-----GGDAGALPVPVPFRE 1226 Query 1194 YSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAA 1253 + V Q+ L G+ + + + +L L+G + P P LL GD + A Sbjct 1227 F-VAQARL-----GVSRAEHERFFGEL--LSGVS--EPTAPF-GLLDVHGDGSDVTEATA 1275 Query 1254 IRD-----KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANL--DQ 1306 + D +L +R L V+ L A V G DV G+ + GR +A D+ Sbjct 1276 VLDADLAARLREQARRLSVSPATLFHLVWARVAAVTSGRDDVVFGSVLFGRMQAGTGADR 1335 Query 1307 LIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNP 1366 G FIN + +R P V +Q+A H+ P +A + + P Sbjct 1336 TPGLFINTLPVRVPTGQVPVGEAVRAMQKQLA-DLLVHEHAPLMVAQQAADLA---AETP 1391 Query 1367 LFDIVVHVREQMPQDHVIDTGPDGD 1391 LF +++ R TG GD Sbjct 1392 LFTSLLNYRHS--------TGASGD 1408 Score = 427 bits (1097), Expect = 1e-116, Method: Compositional matrix adjust. Identities = 313/857 (37%), Positives = 431/857 (51%), Gaps = 74/857 (8%) Query 210 LPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNR---GAGTEDA 266 L A +AR+ A+ G +P + + + + DD + + + R G G + Sbjct 5219 LDAAVSARLREQARRLGVSPATLFHLVWARVAAVTSGRDDVVFGSVLFGRMQAGTGADRT 5278 Query 267 IGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERM 326 G F NT+ +R+ P + E + + + H+ L + + + Sbjct 5279 PGLFINTLPVRV-PTGRVPVGEAVRGMQKQLADLLVHEHAPLTLAQQAAGLPAQ---TPL 5334 Query 327 TRVSFGFREPDGGGFNP--------PGIECERYDLRSNITQLPLGFMVEFDRAG----VL 374 FR G P G+E RSN PL V D AG V+ Sbjct 5335 FTSLLNFRHNTAGSTGPDDAMSGALEGVELLSAHERSN---YPL--TVSVDDAGSRFDVV 5389 Query 375 VEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNT--LSGLALMDERDAARLREVSRGE 432 V+A L P ++ L AL L + ++DE D +L Sbjct 5390 VQA---AAPLSPQAVTGLIHAAAANLVTALEEETGATGLHEVQVLDETDQRQLLTRWNDT 5446 Query 433 RFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRV 492 + PV TL L +Q RTPDA AV +EG +Y +L+ +NRL LI +G+G E V Sbjct 5447 AHEVPVTTLPRLFADQAGRTPDAVAVTFEGAELSYAELDARTNRLARLLIARGVGPESVV 5506 Query 493 AVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT--------- 543 AV +++S +L+V L V+K+G YVPVDP YP DR+ ++ D LVL + Sbjct 5507 AVSMERSAELVVALLAVLKTGGAYVPVDPEYPADRIAYMFGDARPVLVLTSRSAAGGLPV 5566 Query 544 -------------PVRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPH 590 V LAG + + + + L D+ AY+IYTSG+TG PKGVAVPH Sbjct 5567 VAGLDRVVVDEPQTVTALAGLDAGEIAETELRCALLADHPAYVIYTSGSTGNPKGVAVPH 5626 Query 591 RPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVI-PRPGGLTDIG 649 R V + F KG YD D S SFD S+ E++G L G R+V+ P + G Sbjct 5627 RNVVQLFEAAKGRYDFGADDVWTWFHSFSFDFSVWEMWGALLHGGRLVVVPHAISRSPGG 5686 Query 650 YLTALLRDEGITAMHFVPS----LLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKF-- 703 +L L+R E +T ++ PS L+ P L+ V GGE L ++ Sbjct 5687 FLDLLVR-ERVTVLNQTPSAFYQLVQAEAEAPDAGSRLALRFVIFGGEALDHRRLTEWFV 5745 Query 704 -HATFDALLHNFYGPTETVINASRFKVVGPQ--GTRIVPIGRPKINTTMHLLDDSLQPVP 760 H L N Y PTET + + + V + T ++PIG P NT ++LDDSL PVP Sbjct 5746 RHPENAPALVNMYAPTETTVVCTAYPVSAREEDSTGVLPIGSPMWNTRAYVLDDSLCPVP 5805 Query 761 TGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP-GSRMYRSGDLARRNADGDIEFVG 819 GV GE+Y+ G ++ GY R GLTAERFVA PF G RMYR+GD+ RR ADG +++VG Sbjct 5806 VGVAGELYLAGAQLSRGYTHRPGLTAERFVACPFGAAGERMYRTGDVVRRRADGHLDYVG 5865 Query 820 RADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVT--PAAGGDGP 877 RAD+QVK+RGFRIELG++ A +A P VGQA VVV + K LVGYV PAA G Sbjct 5866 RADDQVKVRGFRIELGEIEAVLASHPLVGQAAVVVREDSPGDKRLVGYVVADPAAENSGA 5925 Query 878 ADVGVDLDR------IRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASD 931 A DL +R V LP++M+P+A + LD +P+T +GK+DR ALP P Sbjct 5926 AS---DLSASALSAAVRGYVRERLPDHMVPSAVLRLDVLPLTVNGKLDRRALPAPDYRVA 5982 Query 932 TEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGV 991 RAP T E+ L LF E+LG VG DDSFFDLGGHSLLAT+LV+ VR A GV++ + Sbjct 5983 GSNRAPSTPREKELCDLFAEVLGVPEVGVDDSFFDLGGHSLLATRLVSRVRTALGVELPI 6042 Query 992 REIFEFATVTALAGHID 1008 R +FE TV LA ++ Sbjct 6043 RTLFEAPTVAGLASRLE 6059 Score = 403 bits (1035), Expect = 2e-109, Method: Compositional matrix adjust. Identities = 440/1469 (30%), Positives = 657/1469 (45%), Gaps = 182/1469 (12%) Query 30 RLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVL 89 R +A+ +V RH ILRT + +G+ +P V LR + L+ R ++ Sbjct 1099 RFLEALQSVVDRHDILRTGF--AWEGLREP-VQVVLREATLPVEELQLAPRPDTDPVQQF 1155 Query 90 AQREFCAPFELSRDAPL-RITVV-RTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSR 147 E C+P R APL R TV D ++ L AHH+ D + + ++ R Sbjct 1156 L--ELCSPSLDIRQAPLLRATVAAEPGGDRWLVALQAHHLVRDHTTLEILLGEV-----R 1208 Query 148 ADLGADLGP--------EHRPSAASGPDTTEADLNYWRAI--MADPPEPLELPGPAGTCV 197 LG D G E A G E + + + +++P P L G Sbjct 1209 TLLGGDAGALPVPVPFREFVAQARLGVSRAEHERFFGELLSGVSEPTAPFGLLDVHGDGS 1268 Query 198 PTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVL 257 + AT L AD AAR+ A+ +P + + + + DD + + + Sbjct 1269 DVT----EATAVLDADLAARLREQARRLSVSPATLFHLVWARVAAVTSGRDDVVFGSVLF 1324 Query 258 NR---GAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRE 314 R G G + G F NT+ +R+ P + E + A + + H+ L +V + Sbjct 1325 GRMQAGTGADRTPGLFINTLPVRV-PTGQVPVGEAVRAMQKQLADLLVHEHAPL--MVAQ 1381 Query 315 LNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRS--NITQLPLGFMVEFDRAG 372 D T + +R G + P I + +L S T P+ V+ G Sbjct 1382 QAADLAAETPLFTSL-LNYRHSTGASGDEPSIGLDGVELLSVRERTNYPVTVSVDDTGDG 1440 Query 373 VLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLAL-----MDERDAARLRE 427 + V+ P A+ + G + +AA +N GL L + + RL Sbjct 1441 FGLT----VQTAAPLDAESVCGLLGAAAEGVVAALENESEGLLLGRVPVLGGAEQDRLVR 1496 Query 428 VSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIG 487 GE +L +L Q RTP+ATAV +EG ++Y +L+ +NRL LI +G+G Sbjct 1497 EWSGESRPVAEASLTELFAAQAVRTPEATAVTFEGVGWSYAELDARANRLARLLITRGVG 1556 Query 488 SEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVL-----R 542 E VAV +++S DL+V L V+K+G YVP+DP YP DR+ ++L D LVL R Sbjct 1557 PESLVAVCMERSADLVVALLAVLKAGGAYVPIDPEYPADRIAYVLEDAQPALVLTSESVR 1616 Query 543 TPVRELAGYR----------------SDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGV 586 + V + G S +P + + P + AY+IYTSG+TG PKGV Sbjct 1617 SVVPGVEGLERVVVDAAQTVSALADLSGEPVSSVEV---LPSHVAYVIYTSGSTGRPKGV 1673 Query 587 AVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARM-VIPRPGGL 645 A+PH V F G + D S +FD S+ E++G L G R+ V+PR Sbjct 1674 AIPHGNVVALFGGTDGWFGFGTGDVWAWFHSFAFDFSVWELWGALLHGGRLVVVPREVSR 1733 Query 646 TDIGYLTALLRDEGITAMHFVPSLLGLFLSL----PGVSQWRTLQRVPIGGEPLPGEVAD 701 L LL + +T ++ PS ++ P + + L+ V GGE L Sbjct 1734 NPREVLE-LLVAQHVTVLNQTPSAFYQLMAAENRDPELGERLALRCVVFGGEALDLSRLR 1792 Query 702 KF---HATFDALLHNFYGPTETVINASRF----KVVGPQGTRIVPIGRPKINTTMHLLDD 754 + HA +L N YG TET ++ S VV ++ +G P N + +L Sbjct 1793 AWYTRHAADTPVLVNMYGITETTVHVSYMPLDEAVVAADTGSVIGMGIP--NLRVFVLGS 1850 Query 755 SLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NPGSRMYRSGDLARRNADG 813 L+PVP GV GE+Y+ G +A GY R GLTAERFVA+PF PG RMYR+GD+ R DG Sbjct 1851 DLRPVPVGVPGELYVAGAQLARGYVGRPGLTAERFVANPFGTPGERMYRTGDVVRWRTDG 1910 Query 814 DIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAG 873 ++EF+GRAD+QVK+RGFRIELG++ A + V QA V+V + K L YV PA Sbjct 1911 NLEFLGRADDQVKVRGFRIELGEIEATLMSHAAVAQAAVLVREDVPGDKRLTAYVVPAVP 1970 Query 874 GDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTE 933 GD D +RA V A LPEYM+P+A VVLD +P+T +GK+DR ALP P+ + T Sbjct 1971 GD-----TADTTALRAHVGARLPEYMVPSATVVLDALPLTVNGKLDRRALPAPE-HTATA 2024 Query 934 FRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVRE 993 RAP A E L +F E+LG VG DD+FF+LGGHSLLA L+ +R GV V VR+ Sbjct 2025 GRAPANAQEEILCSVFAEVLGVPGVGIDDNFFELGGHSLLAVSLIERLRER-GVSVSVRD 2083 Query 994 IFEFATVTALAG------------HIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNY 1041 +F TV LA ++ +++ P + + V L+++++ + Sbjct 2084 LFAAPTVAGLAAASADGERVSVPENLIPAGAETITPEMLPL-----VELTAAEIER-ISA 2137 Query 1042 RFDGPNA-----------VNNIPFAAALHGPCDTNA-----------------FAAAITD 1073 R G A I F + L G + F A+ Sbjct 2138 RVQGGAANIADIYPLAPLQEGIFFHSVLGGDSGADVYVLPTVLGFDTRDRAERFLEALQS 2197 Query 1074 VVARHEILRTVY-----REIGGVPHQIIQPPAEVPV-RCAAGSDAAWLRAELNNERGYVF 1127 VV RH+ILRT + RE P Q++ AE+PV G L L Sbjct 2198 VVDRHDILRTGFAWEDLRE----PVQVVLRHAEIPVNEVDLGGFEGDLAQGLLALCSPSL 2253 Query 1128 DLETDWPIRAALLSTP--EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWA 1185 D+ +RA + + P ++ +L+L VHH+ DH + VL ++ T G Sbjct 2254 DIRQAPLLRATVAAEPGGDRWLLALQVHHLVQDHTALAVLLGEVRTLL-----GGDAGAL 2308 Query 1186 PLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 P+PV + ++ V Q+ L G+ + + + +L L+G + P P LL GD Sbjct 2309 PVPVPFREF-VAQARL-----GVSRAEHERFFGEL--LSGVS--EPTAPF-GLLDVHGDG 2357 Query 1246 VEFRLGAAIRD-----KLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRS 1300 + A+ D +L +R L V+ L A V G DV G+ + GR Sbjct 2358 SDVTEATAVLDADLAARLREQARRLSVSPATLFHLVWARVAAVTSGRDDVVFGSVLFGRM 2417 Query 1301 EANL--DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNP 1358 +A D+ G FIN + +R P V +Q+A H+ P +A + Sbjct 2418 QAGTGADRTPGLFINTLPVRVPTGRVPVGEAVRGMQKQLA-DLLVHEHAPLMVAQQAADL 2476 Query 1359 QRSLSRNPLFDIVVHV------REQMPQD 1381 + PLF +++ REQM D Sbjct 2477 A---AETPLFTSLLNYRHNERPREQMSLD 2502 Score = 392 bits (1008), Expect = 3e-106, Method: Compositional matrix adjust. Identities = 440/1479 (30%), Positives = 647/1479 (44%), Gaps = 182/1479 (12%) Query 28 LARLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLE 87 L R + RH LRT + +G+ +P V +R + DL L Sbjct 3939 LDRFLSVLQTAVDRHDTLRTGF--AWEGLREP-VQVVVRHAEIPVNEVDLGGFEGDLAQG 3995 Query 88 VLAQREFCAPFELSRDAPL-RITVV-RTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAY 145 +LA C+P R APL R TV +D ++++ AHH+ D + V F +++ A Sbjct 3996 LLA---LCSPSLDIRQAPLLRATVAAEPGSDRWLMVMQAHHLVQDHTAMGVLFAEVS-AL 4051 Query 146 SRADLGADLGP----EHRPSAASGPDTTEADLNYWRAI--MADPPEPLELPGPAGTCVPT 199 R D P E A G E + + + +++P P L G Sbjct 4052 LRGDAAELAAPVPFREFVAQARLGVSRAEHERFFGELLSGVSEPTAPFGLLDVHGDGSDV 4111 Query 200 SWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNR 259 + AT L AD AAR+ A+ +P + + + + DD + + + R Sbjct 4112 T----EATAVLDADLAARLREQARRLSVSPATLFHLVWARVAAVTSGRDDVVFGSVLFGR 4167 Query 260 ---GAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELN 316 G G + G F NT+ +R+ P + E + + + H+ L + + Sbjct 4168 MQAGTGADRTPGLFINTLPVRV-PTGRVPVGEAVRGMQKQLADLLVHEHAPLTLAQQAAD 4226 Query 317 P-----------DRRHGAERMTRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFM 365 + R A R+ E + G G+E R+N P+ Sbjct 4227 LAAETPLFTSLLNYRQNANAAQRLGRSIAELNTG---LDGVELLSAHERTN---YPVTVS 4280 Query 366 VEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLAL-----MDER 420 V+ G + V+ P A+ + R + +AA +N GL L + Sbjct 4281 VDDTGEGFGLT----VQAAAPITAQAVCRLVSSTAEGVVAALENESEGLLLGRVPVLGGA 4336 Query 421 DAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHW 480 + RL GE +L +L Q RTP+ATAV +EG ++Y +L+ +NRL Sbjct 4337 EQDRLVREWSGESRPVAEASLTELFAAQAVRTPEATAVTFEGVGWSYAELDARANRLARL 4396 Query 481 LIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLV 540 LI +G+G E VAV +++S DL+VT L V+K+G YVP+DP YP DR+ ++L D LV Sbjct 4397 LIARGVGPESLVAVCMERSADLVVTLLAVLKAGGAYVPIDPEYPADRIAYVLEDAQPALV 4456 Query 541 LRT-------------PVRELAG---------YRSDDPTDADRIRPLRPDNTAYLIYTSG 578 L + P R L S +P + + P + AY+IYTSG Sbjct 4457 LTSRATADAVTDGANAPARVLVDGTDVLAQLETLSGEPVSSVEVLP---SHVAYVIYTSG 4513 Query 579 TTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMV 638 +TG PKGVAVPH V F G + D S +FD S+ E++G L G R+V Sbjct 4514 STGRPKGVAVPHGNVVALFGGTDGWFGFGTGDVWAWFHSFAFDFSVWELWGALLHGGRLV 4573 Query 639 I-PRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSL----PGVSQWRTLQRVPIGGE 693 + PR L LL E +T ++ PS ++ P + + L+ V GGE Sbjct 4574 VVPREVSRNPREVLE-LLVAEHVTVLNQTPSAFYQLMAAENRDPELGERLALRCVVFGGE 4632 Query 694 PLPGEVADKF---HATFDALLHNFYGPTETVINASRF----KVVGPQGTRIVPIGRPKIN 746 L + HA +L N YG TET ++ S VV ++ +G P N Sbjct 4633 ALDLSRLRAWYTRHAADTPVLVNMYGITETTVHVSYMPLDEAVVAADTGSVIGMGIP--N 4690 Query 747 TTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NPGSRMYRSGD 805 + +L L+PVP GV GE+Y+ G +A GY R GLTAERFVA+PF PG RMYR+GD Sbjct 4691 LRVFVLGSDLRPVPVGVPGELYVAGAQLARGYVGRPGLTAERFVANPFGTPGERMYRTGD 4750 Query 806 LARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLV 865 + R DG++EF+GRAD+QVK+RGFRIELG++ A + V QA V+V + K L Sbjct 4751 VVRWRTDGNLEFLGRADDQVKVRGFRIELGEIEATLMSHAAVAQAAVLVREDVPGDKRLT 4810 Query 866 GYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPE 925 YV PA GD D +RA V A LPEYM+P+A VVLD +P+T +GK+DR ALP Sbjct 4811 AYVVPAVPGDT-----ADTTALRAHVGARLPEYMVPSATVVLDALPLTVNGKLDRRALPA 4865 Query 926 PQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGH--------------- 970 P+ + T RAP A E L +F E+LG VG DD+FF+LGGH Sbjct 4866 PE-HTATAGRAPANAQEEILCSVFAEVLGVPGVGIDDNFFELGGHSLLAVSLIERLRERG 4924 Query 971 ------SLLATKLVAAVRNAFG-------------VDVGVREIFE--FATVTALAGHIDT 1009 SL AT VA + A G + G I V A I+ Sbjct 4925 LSVSVRSLFATPTVAGLAVALGAGGQGAVSVPENLIPAGAETITPEMLPLVELTAAEIER 4984 Query 1010 LDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALH--GPCDTNAF 1067 + SAR + + L+ Q +F++ G + L + F Sbjct 4985 I---SARVQGGAANIADIYPLAPLQEGLFFHHLMTGEGEADVYLQQTVLRFDARQRVDRF 5041 Query 1068 AAAITDVVARHEILRTVYREIG-GVPHQIIQPPAEVPVR------CAAGSDAAWLRAELN 1120 A+ V+ RH+ILRT + G P Q++ AEVPV + G DA +L Sbjct 5042 VEALQAVMVRHDILRTGFAWEGLREPVQVVVRRAEVPVHEVALDAVSGGQDAV---QQLL 5098 Query 1121 NERGYVFDLETDWPIRAALLSTP--EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARST 1178 + D+ +RA + + P ++ ++ L HH+ DH + +L ++ RA Sbjct 5099 DAADRTMDVGRAPLLRAYIGAEPGSDRWLMLLQNHHLVEDHTALELLLAEV----RAHLE 5154 Query 1179 GQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPAL 1238 GQ + P PV + ++ V Q+ L G+ + + + +L L+G T P P L Sbjct 5155 GQEDAL-PAPVPFREF-VAQARL-----GVSRAEHERFFGEL--LSGVT--EPTAPY-GL 5202 Query 1239 LSGAGDAVEF-----RLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIG 1293 L GD E L AA+ +L +R LGV+ L A V G DV G Sbjct 5203 LDVRGDGTEVDEVMSTLDAAVSARLREQARRLGVSPATLFHLVWARVAAVTSGRDDVVFG 5262 Query 1294 APVAGRSEANL--DQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMA-LAAYAHQDLPFD 1350 + + GR +A D+ G FIN + +R P V +Q+A L + H L Sbjct 5263 SVLFGRMQAGTGADRTPGLFINTLPVRVPTGRVPVGEAVRGMQKQLADLLVHEHAPLTLA 5322 Query 1351 QVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPD 1389 Q + Q PLF +++ R TGPD Sbjct 5323 QQAAGLPAQ-----TPLFTSLLNFRHNTAG----STGPD 5352 Score = 129 bits (324), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 119/465 (26%), Positives = 194/465 (42%), Gaps = 32/465 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + A NI + + G +D L A+N V RH +LRT +P+ D QP Sbjct 3208 LWFLGELEGPNATYNIPAAIHLHGTLDTQALSAALNDVVARHEVLRTVFPMVD---GQPQ 3264 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 L P + +LT + Q + F+L+ D PLR + T +EH+L Sbjct 3265 -QRILDPDQARCELTTMELSPQNAEEAMAEAAAGV--FDLATDLPLRAWLFTTGTNEHIL 3321 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT---------EA 171 +LV HH+A D S D++ AY+ + P P D T E Sbjct 3322 MLVLHHVAGDGWSMAPLAHDVSLAYTAHTTSST--PTWEPLPVQYADYTLWQRELLGDET 3379 Query 172 D--------LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D L YWR +AD P+ L LP + + L + D R+ A+ Sbjct 3380 DPHSLMAQQLAYWRQALADIPDELALPLDRPRPAIATHQGGIVDLTIEPDIHTRLLHTAR 3439 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 G T +MVL AA AL++R D + PV R E+ +G+F NT+ +R + Sbjct 3440 THGVTLFMVLQAATAALLNRLGAGRDIPLGVPVAGRSDEALENLVGFFVNTLVIRTDLTA 3499 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 SF +LL R+ A H I +R+V EL P R + ++ + Sbjct 3500 DPSFTQLLEQVRETGLAAHTHADIPFERLVEELAPTRSMARHPLFQIMLSLDTHADAVVD 3559 Query 343 PPGIECERYDLRSNITQLPLGFMV--EFDR----AGVLVEAEHLVEILEPALAKQMLRHF 396 PG++ E + + + L V FD AG+ + V++ + A +++ F Sbjct 3560 LPGLDAEVIASKDSAAKFDLDLNVRERFDASGAPAGLRGTVVYAVDLFDEATVAELVERF 3619 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTL 441 +L+ A P +S + ++ + + R+ +G P +T+ Sbjct 3620 VRVLEAVTADPHQPVSRIRILGDAELDRILTEWKGCATGIPARTV 3664 Score = 70.5 bits (171), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 35/73 (48%), Positives = 45/73 (62%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RV++L L+PVPVGV G++Y G + RP TA RFVA+PF PG R+YR G+ Sbjct 1844 RVFVLGSDLRPVPVGVPGELYVAGAQLARGYVGRPGLTAERFVANPFGT-PGERMYRTGD 1902 Query 1543 RGVWKADGQLELL 1555 W+ DG LE L Sbjct 1903 VVRWRTDGNLEFL 1915 Score = 70.5 bits (171), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 35/73 (48%), Positives = 45/73 (62%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RV++L L+PVPVGV G++Y G + RP TA RFVA+PF PG R+YR G+ Sbjct 4692 RVFVLGSDLRPVPVGVPGELYVAGAQLARGYVGRPGLTAERFVANPFGT-PGERMYRTGD 4750 Query 1543 RGVWKADGQLELL 1555 W+ DG LE L Sbjct 4751 VVRWRTDGNLEFL 4763 Score = 68.9 bits (167), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 35/73 (48%), Positives = 44/73 (61%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RVY+LD AL+PVP GV G++Y G L RP +A RF+A PF G R+YR G+ Sbjct 749 RVYVLDAALRPVPAGVPGELYVAGDQLARGYLGRPGLSAERFIACPFGTA-GERMYRTGD 807 Query 1543 RGVWKADGQLELL 1555 W+ DG LE L Sbjct 808 VVRWRTDGNLEFL 820 Score = 63.9 bits (154), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/71 (50%), Positives = 43/71 (61%), Gaps = 1/71 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R Y+LDD+L PVPVGV G++Y G RP TA RFVA PF A G R+YR G+ Sbjct 5793 RAYVLDDSLCPVPVGVAGELYLAGAQLSRGYTHRPGLTAERFVACPFGAA-GERMYRTGD 5851 Query 1543 RGVWKADGQLE 1553 +ADG L+ Sbjct 5852 VVRRRADGHLD 5862 Score = 55.5 bits (132), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 31/76 (41%), Positives = 48/76 (64%), Gaps = 1/76 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T E+ L + A+VL V EVG D FF+LGG S+LAT++ +R R G+ L R +FE P Sbjct 5990 TPREKELCDLFAEVLGVPEVGVDDSFFDLGGHSLLATRLVSRVRTALGVELPIRTLFEAP 6049 Query 1635 VLCELAAAVDAKPHVE 1650 + LA+ ++A+ + + Sbjct 6050 TVAGLASRLEARTNTK 6065 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/87 (38%), Positives = 47/87 (55%), Gaps = 6/87 (6%) Query 1559 ERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 1618 E TA AP A+ E L ++ A+VL V VG D+FF LGG S+LA + R Sbjct 4867 EHTATAGRAPANAQ------EEILCSVFAEVLGVPGVGIDDNFFELGGHSLLAVSLIERL 4920 Query 1619 RDGGIPLTARMVFEHPVLCELAAAVDA 1645 R+ G+ ++ R +F P + LA A+ A Sbjct 4921 RERGLSVSVRSLFATPTVAGLAVALGA 4947 Score = 51.2 bits (121), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/84 (40%), Positives = 46/84 (55%), Gaps = 6/84 (7%) Query 1559 ERLPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARA 1618 E TA AP A+ E L ++ A+VL V VG D+FF LGG S+LA + R Sbjct 2019 EHTATAGRAPANAQ------EEILCSVFAEVLGVPGVGIDDNFFELGGHSLLAVSLIERL 2072 Query 1619 RDGGIPLTARMVFEHPVLCELAAA 1642 R+ G+ ++ R +F P + LAAA Sbjct 2073 RERGVSVSVRDLFAAPTVAGLAAA 2096 Score = 48.5 bits (114), Expect = 0.010, Method: Compositional matrix adjust. Identities = 94/394 (24%), Positives = 147/394 (38%), Gaps = 77/394 (19%) Query 1114 WLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVL---FTDL 1169 W+R ++ D+ D A+L P+ HHI GD +S ++ + Sbjct 67 WMRTDMRRP----VDMRGDALFTQAMLRLGPDHVYWYQRCHHILGDGFSGPLVNNRIAQI 122 Query 1170 LTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQ-----RDYWIRQLGGLA 1224 A RA + AP S LLD G + R YW Sbjct 123 YAALRAGDAYDEGALAPF-----------SNLLDADRAYRGSEEQAKDRAYW-------- 163 Query 1225 GETGLRPDFPRPALLSG---AGDAVEFRLGAAIRDKLAA-----VSRDLGVTEFMLLQAA 1276 GE + D P P LSG AG G A AA +R L + + AA Sbjct 164 GE--IFADLPTPVSLSGRIPAGTPHHLIRGTAEMPSEAAADLRTTARSLRTSISGMAIAA 221 Query 1277 VAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQ 1336 AV L++A G DV + PV GR + Q G N++ +R +R + T++E++++ Sbjct 222 AAVYLNRATGAEDVVVALPVFGRFGSAQRQTPGMATNLLPIRLTVRSSMTVQELVRQVSV 281 Query 1337 MALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV---------REQMPQDHVIDTG 1387 A HQ ++ ++ + R + R L +VV+V + + H + +G Sbjct 282 QVRGALRHQKYRYEDMLRDL---RLIGRGNLASMVVNVVPYAYDFSFGDCEVRAHALSSG 338 Query 1388 PDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRT----ELYERATAQRFADWLV 1443 D V + + D G + T ELY QR D L Sbjct 339 HFNDVAFCVYDRSAD------------------GRIQIATDASPELYSPHANQRHTDRLH 380 Query 1444 RVVEAFAD-RPDQPLREVEMVSAQARRRILDRSN 1476 V+ A P+ + VE++ RR++L N Sbjct 381 TVLTWLATAAPEDRVGRVEILDEAERRQVLQDWN 414 Score = 42.0 bits (97), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/53 (42%), Positives = 32/53 (61%), Gaps = 0/53 (0%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVF 1631 E L A+ A+VL V VG D+FF LGG S+LA + R+ G+ ++ R +F Sbjct 942 EEILCAVFAEVLGVPAVGVDDNFFELGGHSLLAVSLIELLRERGMSVSVRDLF 994 >gi|111017166|ref|YP_700138.1| non-ribosomal peptide synthetase [Rhodococcus jostii RHA1] gi|110816696|gb|ABG91980.1| non-ribosomal peptide synthetase [Rhodococcus jostii RHA1] Length=10372 Score = 873 bits (2255), Expect = 0.0, Method: Compositional matrix adjust. Identities = 579/1584 (37%), Positives = 846/1584 (54%), Gaps = 91/1584 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + N+ V+ R++G++DL ++ A+ + RH LRT YP DG Q Sbjct 7976 MWFINQFDTASPAYNLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVYPDSVDGPHQVI 8035 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V A G DLT ++ + VLA F+++ D PLR + R AD++VL Sbjct 8036 VPA----GDAVPDLTPVAAHPDDVLDRVLAL--VTTGFDVTADVPLRARMYRVGADDYVL 8089 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------AD--------LGPEHRP 160 ++VAHHI+ D S D+ AY+ G AD LG E P Sbjct 8090 VMVAHHISGDGWSLAPLARDVMLAYTARAEGHVPRWTPLPVQYADYSLWQRELLGDETDP 8149 Query 161 SAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVAT 220 + + A + YW + P+ LP S A + A T + Sbjct 8150 ESVAA-----AQIAYWTRTLEGLPDRPSLPTDRPRPAVASHLGAHVPFTIDAGTHRALLA 8204 Query 221 MAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVAMRLR 279 +A+ + +MV+ A L+ R ++ D V AP+ RG + D +G F NT+ +R R Sbjct 8205 LARGRNTSLFMVMHTALAVLLARLSNESDIAVGAPIAGRGEESLDELVGMFVNTLVLRTR 8264 Query 280 PQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGG 339 A SF + L R AFAH I +R+V LNP R + +V+F F+ Sbjct 8265 VALASSFADSLADVRSADLNAFAHSDIPFERLVDVLNPARSRAHHPLFQVAFSFQNLATT 8324 Query 340 GFNPPGIECERYDLRSNITQLPLGFMV----EFDRAGVLVEAE--HLVEILEPALAKQML 393 PG+ E D+ + I+ L + + D + ++EA+ + ++ + + + Sbjct 8325 TLELPGLHVEGLDVPNTISNFDLHLTLSEKHDADGSPDVIEAQFTYATDLFDESTVRAFA 8384 Query 394 RHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTP 453 F +L + + PD + + L+D + + D P TL +L + Q RTP Sbjct 8385 ERFTRVLASVVEDPDVAVGAIDLLDGPERQSIVADFNDTGVDLPPTTLAELFSAQAARTP 8444 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 + AV +EG TY + + + L H LI++G+G E V + +++S +L+V V+++G Sbjct 8445 EKAAVFFEGTELTYAEFDRRVDVLAHRLIDRGVGPESVVGLAMNRSIELLVGMYAVLRAG 8504 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRT----------PVREL-----AGYRSDDPTD 558 Y+P+D ++P DRL ++LA +L T PV E+ G + TD Sbjct 8505 GAYLPIDLTHPADRLAYVLATARPVCILTTSSDGFAAESVPVIEIDTLDHTGSPREPVTD 8564 Query 559 ADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP 618 A R+ PLRP+NTAYLI+TSG+TG PKGVAV H +A W + EY +D TD ++Q Sbjct 8565 ARRLAPLRPENTAYLIFTSGSTGRPKGVAVTHAAIANQLRWKQHEYSLDTTDAVVQKTPV 8624 Query 619 SFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPG 678 +FD+S+ E+F L GAR+VI RP G D YL L+R + +T HFVPSLL FL+ P Sbjct 8625 TFDLSVWELFWPLTTGARLVIARPDGHRDPAYLADLMRQQRVTTAHFVPSLLEAFLATPD 8684 Query 679 VSQWRTLQRVPIGGEPLPGEVADKFHATFDAL-LHNFYGPTETVINASRFKVVGPQGTRI 737 + L+RV GE LP + A +F F + LHN YGPTE ++ + + Sbjct 8685 AGEQPALRRVLCIGEALPVDTAARFRRRFGTVALHNLYGPTEAAVSVTAWTHTA-DDVDT 8743 Query 738 VPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-P 796 VPIG P+ NT + +LD L PVP GV GE+Y+ G +A GY RA LTAERFVA+PF Sbjct 8744 VPIGGPEWNTQVFVLDARLNPVPVGVAGELYLAGEQLARGYVARADLTAERFVANPFGAS 8803 Query 797 GSRMYRSGDLAR---RNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVV 853 GSR+YR+GD+ R R++ G +E++ R+D QVK+RGFRIELG++ +A+ VGQAVVV Sbjct 8804 GSRLYRTGDVVRWHVRDSRGVLEYLERSDFQVKVRGFRIELGEIESALVSSAGVGQAVVV 8863 Query 854 VSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPIT 913 P G +L+GYV P G VD + A V AA+P YM+PAA VVL ++P+T Sbjct 8864 AHQHPHTGTTLIGYVVPEDGAT------VDFAAVLAEVGAAVPSYMVPAALVVLAQLPLT 8917 Query 914 AHGKIDRAALPEPQIASDT-EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSL 972 ++GK+DR ALP P AS T E+RAP T TE +A +F ++LG D+VG +FFDLGG+SL Sbjct 8918 SNGKLDRRALPAPDFASATDEYRAPATPTEEAVAAVFADVLGVDQVGTAANFFDLGGNSL 8977 Query 973 LATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDS-ARPRLTRVDHDGPVRLS 1031 +AT++VA + G V +R +FE TV ALA +D++D+ + ARP LT + LS Sbjct 8978 VATRVVARLSERLGCRVEIRTLFEAPTVAALAALLDSIDATAPARPALTPAVRPERIPLS 9037 Query 1032 SSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGV 1091 S+Q R WF RFD +AV+NIP A L G D +A A+ DVV RHE LRTVY + Sbjct 9038 SAQHRMWFLNRFDPNSAVHNIPAAVRLSGALDVDALQHAVADVVRRHESLRTVYPDSADG 9097 Query 1092 PHQIIQPPAEVPVRCA-AGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLS 1149 PHQ+I P V + +D A L A + FD+ T+ P+R + + + VL+ Sbjct 9098 PHQVILPIDRVGGEMSVVATDEAALPALIAGLVTTGFDVTTEVPVRVRIFRMSATEHVLA 9157 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGA--- 1206 LVVHHI+GD WS + D++TAY ARS P WAPLPVQYADY++WQ ALL D Sbjct 9158 LVVHHISGDGWSMAPMVRDVMTAYAARSADTTPDWAPLPVQYADYALWQRALLGDETDPE 9217 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 + Q +W L G + L D PRPA+ S G V+F + A + L +RD Sbjct 9218 SVSARQLAFWTHTLAGAPDQLDLPTDRPRPAVASYRGGTVDFTVPADLHGTLLGAARDAN 9277 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 + FML+ AA+AV+L + G D+ IG PVAGR E LD LIG F+N +VLR + G T Sbjct 9278 ASLFMLVHAALAVLLSRLSGTGDIAIGTPVAGRGERELDDLIGMFVNTLVLRQQVDGGRT 9337 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 E++ R+ LAA++H D+PF+++VE VNP RS R+PLF +++ Q+ T Sbjct 9338 FAELVADVRETDLAAFSHADVPFERLVEVVNPSRSTGRHPLFQVMLTF-----QNLDQAT 9392 Query 1387 GPDGDTTLRVLEPTFDAAQADLSV----NFFACG--DEYRGHVIYRTELYERATAQRFAD 1440 GD ++ ++ D A+ DL + F + G D + Y ++L++ + F Sbjct 9393 LRLGDLSVSGVDFDVDIAKFDLQLTLMEQFDSAGSPDGIAARLTYASDLFDEPSMHVFGQ 9452 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAG----AGT-ARVYLLDDALKPVP 1495 +V+ A D PD + +++++ + R++I + AGT A ++ A PV Sbjct 9453 RFQQVLRAATDSPDTAVGDIDVLGSGERKQIAGTNATSHEVPAGTLASLFDTRVAADPVR 9512 Query 1496 VGVVGD---VYYGGGPAVGARLAR 1516 V V+ D + Y A RLAR Sbjct 9513 VAVIFDRDELTYADFDARVNRLAR 9536 Score = 841 bits (2172), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/1540 (36%), Positives = 805/1540 (53%), Gaps = 94/1540 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + N+ +S R+TG +D LR A+ V RH LRT +P DG Q Sbjct 1105 MWFLNQFDTASPAYNLPISLRLTGALDREALRAALGDVQERHEALRTVFPDTPDGPHQLV 1164 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V + + D D+ ++ + L A F+L+ D PLR + R A D HVL Sbjct 1165 V--PVVSVLAETDPIDVDAKSLTAAVTALG----GAGFDLTTDTPLRAGLFREAPDRHVL 1218 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAAS--GP 166 +LV HH+A D S D+ AY+ G AD R S P Sbjct 1219 VLVVHHVAADGWSMTPLAADVMVAYAARVAGHAPTWAPLPVQYADYTLWQRELLGSEDDP 1278 Query 167 DTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 D+ A + +W++ +A P+ LELP S R R + AD R+ +A++T Sbjct 1279 DSVSARQIAHWQSALAGVPQLLELPADRPRPAEMSHRGGRVEFTITADVHGRLVDLAQST 1338 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQSAM 284 G T +MV AA L HR D ++ PV RG +D +G F NT+ +R + Sbjct 1339 GTTLFMVTHAALVVLFHRLGAGTDIVIGTPVAGRGEEALDDLVGMFVNTLVLRATAEPGD 1398 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 +F E+L RD AF+H + +R+V L+PDR + +V F+ P Sbjct 1399 TFEEVLDRVRDADLAAFSHADVPFERLVEVLSPDRSAARHPLFQVMLSFQNTAPTSVELP 1458 Query 345 GIECE---------RYDLRSNITQ------LPLGFMVEFDRAGVLVEAEHLVEILEPALA 389 G+E ++DL+ +T+ +P G FD A ++ + + Sbjct 1459 GLEVAAAEIDVHVAKFDLQLTVTERFVGAGMPGGLAAGFDYA---------TDLFDESTV 1509 Query 390 KQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQT 449 M F LL + A+ + L+L+ + RL P L +L + Q Sbjct 1510 ASMAERFANLLRSVAASSATVVGDLSLLHAAERDRLLGTWNDTAHRVPAMCLPELFDAQV 1569 Query 450 TRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGV 509 RTPDA AVV+ +Y L+ +N + +LI++G+G E RV + + +SPDL+V + Sbjct 1570 ARTPDAVAVVFGDVTLSYSQLDCRANSVARYLIDRGVGPESRVGLAMRRSPDLLVGMYAI 1629 Query 510 VKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRE----------------LAGYRS 553 VK+G YVPVDP +P DR+ ++L VL T L Y Sbjct 1630 VKAGGAYVPVDPDHPTDRIGYVLDSAQPVCVLTTSADRGALPAGQSFVEIDRIALDSYSG 1689 Query 554 DDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLL 613 TD+DR+ PLRPDN AY+IYTSG+TG PKGV+VPHR + +W + EY + + D LL Sbjct 1690 GPVTDSDRLAPLRPDNPAYVIYTSGSTGRPKGVSVPHRGIVNQLLWMQSEYALTERDVLL 1749 Query 614 QVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLF 673 Q + +FDVS+ F L GA MV+ P G D YL ++ + G+T FVPS+L F Sbjct 1750 QKTATTFDVSLWGYFWPLHTGATMVLATPDGHRDPEYLARVIDEHGVTVTDFVPSMLDAF 1809 Query 674 LSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGP- 732 ++ ++ TL+ V + GE LP E +F A DA LHN YGPTE ++ + + Sbjct 1810 VASVPITSCSTLRHVFVIGEALPPETVTRFRALSDAGLHNLYGPTEAAVSVTYWDTATTV 1869 Query 733 QGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVAD 792 GT VPIG P+ NT +++LD L PVP GV GE+Y+ G +A GY R LT++RFVA+ Sbjct 1870 AGT--VPIGVPEWNTQVYVLDSRLHPVPPGVAGELYLAGEQLARGYLGRVDLTSDRFVAN 1927 Query 793 PFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVV 852 PF PG RMYR+GDL R + G +E++GR D QVK RG RIELG++ + P+V A V Sbjct 1928 PFTPGLRMYRTGDLVRWTSAGALEYIGRTDFQVKFRGQRIELGEIEFVLRAQPSVTSAAV 1987 Query 853 VVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPI 912 +V P G LV YV P G D +D R+R AA+LP YM+PAA +V+DE P+ Sbjct 1988 LVHSDPGTGDRLVAYVVPEPGHD------LDTTRLRECAAASLPAYMIPAALMVVDEFPL 2041 Query 913 TAHGKIDRAALPEPQI-ASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHS 971 GK+DR ALP P+ S TE+ AP+T+ E LA++F E+LG DR+G D+FFD+GG+S Sbjct 2042 NTSGKLDRQALPAPEFGGSGTEYVAPRTSVEANLAEIFAEVLGLDRIGLRDNFFDVGGNS 2101 Query 972 LLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLS 1031 L+AT++ + +R G + +R++F+ TV ALA I+ + R L G + LS Sbjct 2102 LVATRVTSRIRAELGAPLALRDLFDAPTVGALAERIEGTVQTTPRAPLVAATRAGRIPLS 2161 Query 1032 SSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGV 1091 +Q R WF +FD +A N+PFA L G D + +AI DV+ RHE LRT+Y + Sbjct 2162 PAQRRMWFVNQFDTASAAYNMPFALRLSGILDCDGLRSAIRDVLERHESLRTLYPDSTDG 2221 Query 1092 PHQIIQPPAEVP----VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQT 1146 PHQ+I EVP V+ ++ EL E FD+ + P+R ALL + ++ Sbjct 2222 PHQVIVGADEVPLDLDVQPITEAELPTRLVELATEG---FDVTSAVPLRTALLRLSVDEY 2278 Query 1147 VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---D 1203 VL++VVHHI+ D S L D+L AY AR+ G+ PSW PL VQYADYS WQ+ L Sbjct 2279 VLAVVVHHISADGSSMAPLARDILLAYTARTAGRAPSWPPLDVQYADYSYWQAEFLGDET 2338 Query 1204 DGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSR 1263 DG Q ++W L G+ L D PRPA+ + +G V F + AA +A ++ Sbjct 2339 DGRSQATEQIEFWSAALDGIPDLLELPADRPRPAMPTNSGATVPFSVDAATAKAVADLAA 2398 Query 1264 DLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRG 1323 T FM+ AA++V+L + VDV +G PVAGR+E +L L+G F+N + LR + G Sbjct 2399 RSAATPFMVWHAALSVLLSRLSNAVDVTVGTPVAGRAEPSLQDLVGMFVNTLTLRARVSG 2458 Query 1324 NPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHV 1383 + + ++L + R+ LAA+AH DLPF+++VE + P RS +R+PLF + + P V Sbjct 2459 DLSFADLLAQVREFDLAAFAHADLPFERLVEVLEPARSTARHPLFQVGLSYENFEPG--V 2516 Query 1384 IDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYERATAQR 1437 ++ T+ +E + A+ DL+V DE G Y +L++R T + Sbjct 2517 LEL---PGLTVSAVEMNPEIAKFDLNVTLTEIRDERGTVSGLTGAFTYAVDLFDRDTVES 2573 Query 1438 FADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 FAD R+V A P + ++ ++ + R+L NA Sbjct 2574 FADRFARIVTAALADPGTAVGDLPVLDQRELVRVLREWNA 2613 Score = 739 bits (1907), Expect = 0.0, Method: Compositional matrix adjust. Identities = 537/1545 (35%), Positives = 761/1545 (50%), Gaps = 110/1545 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ + S N+ + R+TG +D A L A++ + RH LRT +P G Q Sbjct 6918 MWFLNQFETSSPAYNLPAAVRLTGPLDTAALAAAIDDLITRHESLRTVFPDSRGGPHQVI 6977 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 L PG D + LR ++ ++ F++S+ PLR+ V EHVL Sbjct 6978 ----LEPGQFTPDTAPVRVSESGLRADL--EQFLLTGFDVSQAVPLRVKVYSLGDTEHVL 7031 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGP-------------- 166 V HHIA D S D+ AYS G H PS A P Sbjct 7032 AFVVHHIAADGVSMEPLIRDVMIAYSSRAAG------HAPSWAPLPVQYADYALWQREVL 7085 Query 167 -------DTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVA 219 A L YW +A P+ L LPG G S R A L ADT +A Sbjct 7086 GVESDPGSLAAAQLEYWTRTLAGVPDQLYLPGDRGRPAVPSHRGAATRFTLDADTHRALA 7145 Query 220 TMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRL 278 +A+ G + +MV AA L+ R + S D V + RG +D IG F NT+ +R Sbjct 7146 ELARAHGASIFMVAHAALSVLLGRLSTSSDITVGTAIAGRGRVELDDIIGMFVNTLVLRT 7205 Query 279 RPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDG 338 SF LL RD+ AFAH + +R+V L+P R + +V+ G + Sbjct 7206 TLDPGASFVSLLEQARDVDLEAFAHADLPFERLVEVLSPVRSTSHHPLFQVALGVQAVSA 7265 Query 339 GGFNPPGIECERYDLRSNITQLPLGFMVE------FDRAGVLVEAEHLVEILEPALAKQM 392 G+ E L ++ + L F + + AG+ E + +I + + A + Sbjct 7266 DRLELDGLSLEPLTLDASTAKFDLHFTLTERLDDASEAAGIDAELVYATDIFDESTAAEY 7325 Query 393 LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT 452 + + +A P + + ++ + + A L V + PV+ L +++ + Sbjct 7326 AIRLRRIFEAVVADPQRPIGDIPVLGDEEYAALTPVRGADA--RPVQMLPEILADAVAAA 7383 Query 453 PDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKS 512 PD AVV+EG+ TY DL+E SN+L L+++G+G E RVA+ L +S + +V V K+ Sbjct 7384 PDGPAVVFEGESLTYRDLDERSNQLARLLVDRGVGPETRVALALPRSLESVVAVWAVAKT 7443 Query 513 GAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRE------LAGYRSDDP---------- 556 GA +VPVDP YP DR+ ++ D A + + ++ + DDP Sbjct 7444 GAAFVPVDPGYPADRVLHMVQDSGAMVGITVSAKQDVLPDSIRWMLLDDPALAVRCTHES 7503 Query 557 ----TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRL 612 T+ DR+RP+ D AY+IYTSG+TG PKGVAV HR + + V R Sbjct 7504 RLPLTNRDRMRPILSDQVAYVIYTSGSTGRPKGVAVTHRGLMNLVTDERELLGVTSGSRT 7563 Query 613 LQVASPSFDVSIAEIFGTLACGARMVIPRP---GGLTDIGYLTALLRDEGITAMHFVPSL 669 L ASPSFD S+ E+ L GA MVI P GG L LL E +T P+ Sbjct 7564 LHFASPSFDASVFEMLMALGAGATMVIAPPTIYGG----SELAELLAAEHVTHAFSTPAA 7619 Query 670 LGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKV 729 L + G+ L V + G+ P E+ ++ + N YGP+E I +S + Sbjct 7620 LA-SVDHHGLDD---LAVVVVAGDVCPPELVARWAP--GRRMVNAYGPSEATIMSSITEP 7673 Query 730 VGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERF 789 + + V IG P +LD L+PVP GV GE+Y+GG +A GY R GLTAERF Sbjct 7674 L--RAGEPVTIGGPSRGVRALVLDGRLRPVPVGVPGELYVGGPSLARGYLGRPGLTAERF 7731 Query 790 VADPF-NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVG 848 VADP+ PG MYR+GDL R + ++FVGR D QVKIRGFRIELG++ AA+ P + Sbjct 7732 VADPYGEPGDLMYRTGDLVRWRENRVLDFVGRTDHQVKIRGFRIELGEIDAALTAHPQIE 7791 Query 849 QAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLD 908 A + + P SLV YV P G D VD + V LP YM+PA+ +LD Sbjct 7792 YATTIGYEHPNGETSLVAYVLPFTGED------VDRVEVANFVGRTLPAYMVPASVTLLD 7845 Query 909 EIPITAHGKIDRAALPEPQ-IASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDL 967 +P+T GK+DRAALPEP +A+ T F AP+ E +A +F ++L +G DSFFDL Sbjct 7846 ALPLTPAGKLDRAALPEPIFVAAATTFEAPRNPMEVIVAGIFADILALPEIGIHDSFFDL 7905 Query 968 GGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI-DTLDSDSARPRLTRVDHDG 1026 GG+SLLAT++V+ + A V VGVRE+FE TV ALA I +T RP LT Sbjct 7906 GGNSLLATQVVSRINAALDVHVGVREVFESPTVAALAARITETTTHGVRRPALTAKPRPE 7965 Query 1027 PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR 1086 + LS +Q R WF +FD + N+P A L G D A AI D+V RHE LRTVY Sbjct 7966 HIPLSLAQQRMWFINQFDTASPAYNLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVYP 8025 Query 1087 EIGGVPHQIIQPPAE-VP--VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST- 1142 + PHQ+I P + VP AA D R G FD+ D P+RA + Sbjct 8026 DSVDGPHQVIVPAGDAVPDLTPVAAHPDDVLDRVLALVTTG--FDVTADVPLRARMYRVG 8083 Query 1143 PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL 1202 + VL +V HHI+GD WS L D++ AY AR+ G P W PLPVQYADYS+WQ LL Sbjct 8084 ADDYVLVMVAHHISGDGWSLAPLARDVMLAYTARAEGHVPRWTPLPVQYADYSLWQRELL 8143 Query 1203 DDGA---GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLA 1259 D + Q YW R L GL L D PRPA+ S G V F + A L Sbjct 8144 GDETDPESVAAAQIAYWTRTLEGLPDRPSLPTDRPRPAVASHLGAHVPFTIDAGTHRALL 8203 Query 1260 AVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRN 1319 A++R + FM++ A+AV+L + D+ +GAP+AGR E +LD+L+G F+N +VLR Sbjct 8204 ALARGRNTSLFMVMHTALAVLLARLSNESDIAVGAPIAGRGEESLDELVGMFVNTLVLRT 8263 Query 1320 DLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE--- 1376 + + + L R L A+AH D+PF+++V+ +NP RS + +PLF + + Sbjct 8264 RVALASSFADSLADVRSADLNAFAHSDIPFERLVDVLNPARSRAHHPLFQVAFSFQNLAT 8323 Query 1377 ---QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACG--DEYRGHVIYRTELYE 1431 ++P HV G D T+ FD LS A G D Y T+L++ Sbjct 8324 TTLELPGLHV--EGLDVPNTIS----NFD-LHLTLSEKHDADGSPDVIEAQFTYATDLFD 8376 Query 1432 RATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 +T + FA+ RV+ + + PD + ++++ R+ I+ N Sbjct 8377 ESTVRAFAERFTRVLASVVEDPDVAVGAIDLLDGPERQSIVADFN 8421 Score = 733 bits (1892), Expect = 0.0, Method: Compositional matrix adjust. Identities = 545/1536 (36%), Positives = 776/1536 (51%), Gaps = 111/1536 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ DPS N+ + R++G +D+A L A++ V RH LRT +P DDG AQ Sbjct 4779 MWFINQFDPSSPAYNLPFAVRMSGALDVAALSQALDDVVGRHESLRTVFPDTDDGPAQVV 4838 Query 61 VHA-DLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 V A DL ++ D+ + R+ + F ++S D P+R T+ RT EHV Sbjct 4839 VSAADLS---MPLEVVDVPEGELDSRMIAFSSHGF----DVSEDLPVRATLFRTGPGEHV 4891 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYS-RAD-----------LGADLGPEHRPSAASGPD 167 L + HHIA D S+ D+ AY+ RA+ AD HR S D Sbjct 4892 LAITLHHIAADGWSFGPLGADVMVAYAARAESRSPEWIPLAVQYADYSVWHRAVLGS-ED 4950 Query 168 TTEA----DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 E+ L YW + P+ L+LP S+ + + + + +A+ Sbjct 4951 EPESLARRQLEYWTRTLDGLPDELKLPFDRPRRTEQSYVGGSVGFTITPEIHSGIERLAR 5010 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQS 282 G T +MV AAF L+ R + SDD V AP+ RG ++ +G F NT+ +R R +S Sbjct 5011 EHGATVFMVAHAAFALLLARLSASDDIAVGAPIAGRGERALDNLVGMFVNTLVLRTRIES 5070 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 +F ELLT RD GAF H + +R+V L+P R + + + + Sbjct 5071 TETFAELLTRVRDGDIGAFGHADLPFERLVDVLDPVRTSAHHPVIQTALSMQPTAIDDIE 5130 Query 343 PPGIECERYDLRSNITQLPLGFMVEFD------RAGVLVEAEHLVEILEPALAKQMLRHF 396 PG+ D+ + + + L + D +G+ E + ++ + ++ Sbjct 5131 LPGLRVRVEDIDARVAKFDLQLTLGEDIDPAGVPSGIRAEFTYAADLFDDVTVRRYAGQL 5190 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDAT 456 +L+ +A P + + L+D+ + ARL V RG P + L +++ E P AT Sbjct 5191 VRILETVIADPTTVVGDVNLLDDAERARLAPV-RGPA-SRPSRLLPEVLAESAA-DPSAT 5247 Query 457 AVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVY 516 A+V+ + TY +L+ SN LIE G G E VAV L +S + ++ V K+GA + Sbjct 5248 ALVFGDRSMTYGELDRRSNLWARELIEAGAGPETFVAVALARSIESVLAVWAVAKTGAAF 5307 Query 517 VPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRS-------DDP------------- 556 VPVDP+YP +R+ +L D + L L T + AG DDP Sbjct 5308 VPVDPNYPAERIAHMLGDSGSALGLTT-IEFRAGLPDSTQWLVMDDPDHTALVTSHSSAA 5366 Query 557 -TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQV 615 T ADR+ + D AYLIYTSG+TGLPKGVAV H +A EY++ R L Sbjct 5367 VTAADRLGRMHADQLAYLIYTSGSTGLPKGVAVTHSGLANLLTELADEYELTADARTLHF 5426 Query 616 ASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLS 675 ASPSFD S+ E GA MV+ P + L LL +G+T F P+ L + Sbjct 5427 ASPSFDASVFEYLMAFCRGATMVV-VPHSVYGGTELAELLGAQGVTHAFFTPAALA-SVD 5484 Query 676 LPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQ-- 733 G+ + L + +GGE ++A+++ L N YGPTE+ + ++ GP Sbjct 5485 HTGLDE---LAVIVVGGEAWGADLAERW--VPGRALFNGYGPTESSMMVTQ---SGPLML 5536 Query 734 GTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADP 793 G R+ IG P +LD L PV GV GE+YI G +A GYH+R GLTAERFVA+P Sbjct 5537 GERMT-IGAPVRGVEAFVLDARLHPVSPGVPGELYISGPALARGYHQRLGLTAERFVANP 5595 Query 794 FN-PGSRMYRSGDLAR----RNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVG 848 PG RMYR+GDL R R IE+VGR+D QVKIRGFR+ELG++ + VG Sbjct 5596 HGAPGRRMYRTGDLVRWVESRTGTYVIEYVGRSDFQVKIRGFRVELGEIDSVFRAHSAVG 5655 Query 849 QAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLD 908 A + D +LV YV A+G D VD+D + A V LP +M+P + +VLD Sbjct 5656 FAATIAHDTESGVTALVTYVCAASGND------VDVDDLTAFVGGVLPAHMVPGSIMVLD 5709 Query 909 EIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLG 968 IP+T GK+DR ALPEP S T F AP TA E +A F ++LG R+G DD+FF LG Sbjct 5710 SIPLTPAGKLDRRALPEPVFVSHTRFTAPDTADEIAVAAAFADVLGESRIGVDDNFFALG 5769 Query 969 GHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTL--DSDSARPRLTRVDHDG 1026 G+SL AT++V+ V +AFG V VR +F+ TV L + T D+ S RP LTR +H G Sbjct 5770 GNSLSATQVVSRVGSAFGTRVSVRTLFDNPTVRQLVSAVATSGPDASSGRPALTRREHPG 5829 Query 1027 PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR 1086 + LS +Q R WF ++D ++ NIP A + G D A AA+ DV+ RHE LRTVY Sbjct 5830 RIPLSLAQQRIWFLNQYDPSSSAYNIPLALRMSGRIDVPALRAALGDVLERHESLRTVYP 5889 Query 1087 EIGGVPHQIIQPPAE-----VPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALL- 1140 HQ I P A P+R A D LR G FD+ + P R L Sbjct 5890 GSADGAHQEILPAAAAEFDLTPIRTA--PDQLMLRIAEYAVAG--FDVTREIPFRIHLFR 5945 Query 1141 STPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSA 1200 + VL LV HHIA D WS G L D++ AY +R G PSW PLPVQYADYSVWQ Sbjct 5946 ENRSEHVLLLVAHHIAADGWSFGPLAADVMAAYASRVEGLAPSWEPLPVQYADYSVWQRE 6005 Query 1201 LL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDK 1257 LL DD + Q + W L G L D PRPA+ S G+ V+F + A Sbjct 6006 LLGAEDDPDSLSATQIERWRAALDGAPEALDLPTDHPRPAVASHRGERVDFEIDADTHRG 6065 Query 1258 LAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVL 1317 L ++ G T FM++ AA A +LH+ G D+ IG PVAGR + LD L+G F+N + L Sbjct 6066 LVERAQKGGTTLFMVVHAAFATLLHRLSGSTDIVIGTPVAGRGDEGLDPLVGMFVNTLAL 6125 Query 1318 RNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVH---- 1373 R + ++ +L++ R + L A+ ++PFD++VE + P RS R+PLF ++ Sbjct 6126 RTRIDPGESIDALLEQVRDVDLTAFQDTEVPFDRLVEILRPTRSSDRHPLFQVMFAFQNL 6185 Query 1374 --VREQMPQDHV--IDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTEL 1429 V ++PQ V +D P + + D A A++ V+ G + +EL Sbjct 6186 RPVTMELPQLVVEAVDFDP------HIAKFDLDLALAEI-VDDAGHHHGISGAFTFASEL 6238 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 +ERAT FAD +R++EA A D + ++ ++ A Sbjct 6239 FERATVAGFADRFLRILEAVASADDIAVGDIAILGA 6274 Score = 716 bits (1847), Expect = 0.0, Method: Compositional matrix adjust. Identities = 535/1553 (35%), Positives = 773/1553 (50%), Gaps = 132/1553 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ DPS + NI ++ R++G ID+ LR A+ V RH LRT YP DG Q Sbjct 5840 IWFLNQYDPSSSAYNIPLALRMSGRIDVPALRAALGDVLERHESLRTVYPGSADGAHQEI 5899 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + A ++DLT + +L L + A F+++R+ P RI + R EHVL Sbjct 5900 LPA----AAAEFDLTPIRTAPDQLMLRI--AEYAVAGFDVTREIPFRIHLFRENRSEHVL 5953 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP----------------SAAS 164 LLVAHHIA D S+ D+ AY+ G L P P A Sbjct 5954 LLVAHHIAADGWSFGPLAADVMAAYASRVEG--LAPSWEPLPVQYADYSVWQRELLGAED 6011 Query 165 GPDTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 PD+ A + WRA + PE L+LP S R R + ADT + A+ Sbjct 6012 DPDSLSATQIERWRAALDGAPEALDLPTDHPRPAVASHRGERVDFEIDADTHRGLVERAQ 6071 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 G T +MV+ AAF L+HR + S D ++ PV RG G + +G F NT+A+R R Sbjct 6072 KGGTTLFMVVHAAFATLLHRLSGSTDIVIGTPVAGRGDEGLDPLVGMFVNTLALRTRIDP 6131 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 S LL RD+ AF + DR+V L P R + +V F F+ Sbjct 6132 GESIDALLEQVRDVDLTAFQDTEVPFDRLVEILRPTRSSDRHPLFQVMFAFQNLRPVTME 6191 Query 343 PPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEH----------LVEILEPALAKQM 392 P + E D +I + F ++ A ++ +A H E+ E A Sbjct 6192 LPQLVVEAVDFDPHIAK----FDLDLALAEIVDDAGHHHGISGAFTFASELFERATVAGF 6247 Query 393 LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT 452 F +L+ +A D + +A++ + L V G TL +L+ R Sbjct 6248 ADRFLRILEAVASADDIAVGDIAILGAAEQGSLAPVWGGPLLAN--ATLPELLVATAERY 6305 Query 453 PDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKS 512 PD+TAVV++G Y +L+ S +L LI G+G E VA+ L +S + ++ K+ Sbjct 6306 PDSTAVVFDGVSIDYRELDRRSTQLARALIGMGVGPETYVALALPRSVESVLCVWAAAKT 6365 Query 513 GAVYVPVDPSYPQDRLDFILADCDAK------------------LVLRTP--VRELAGYR 552 GA YVP+DP++P DR+ IL D LVL P +REL+ Sbjct 6366 GAAYVPIDPAHPADRIAHILRDSGVVVGVTCAEFAEHLPGVTDWLVLDDPAVLRELSSAS 6425 Query 553 SDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRL 612 + DADR L D+ AYLIYTSG+TGLPKGV V HR +A + + R+ Sbjct 6426 TAPVGDADRTSALHVDHPAYLIYTSGSTGLPKGVVVSHRGLANLAGSYTTAVRATEESRV 6485 Query 613 LQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGL 672 +ASP+FD+S+ E+ GA +V+ PG + L +L+ E +T M + L Sbjct 6486 AHLASPTFDLSVLELLLAHTSGAALVVCPPGVYGGV-ELHEVLQSERVTHMTITNAALA- 6543 Query 673 FLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGP 732 + G+ R+ + +GG+ P E ++ + L N YGPTE + A+ V+G Sbjct 6544 SVEPEGLDDLRS---IVVGGDACPPETVARWADRLE--LVNGYGPTEVTVGATFSSVLG- 6597 Query 733 QGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVAD 792 QG R + IG P +LD L+PVP GV+GE+Y+ G +A GYH RA LTA RFVA Sbjct 6598 QG-RDITIGGPLPGVAAVVLDSRLRPVPVGVVGELYLLGPALARGYHERAALTAHRFVAS 6656 Query 793 PFNP-GSRMYRSGDLARRNA----------DGD-----IEFVGRADEQVKIRGFRIELGD 836 PF G+RMYR+GD+ R A DG IE++GR+D QVK+RG RIELG+ Sbjct 6657 PFEAAGARMYRTGDIVRWRAVHSGVTGSMTDGTFPGHAIEYLGRSDHQVKVRGLRIELGE 6716 Query 837 VAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALP 896 + AA+ P V A + + P + L +V AG D D + A + ALP Sbjct 6717 IDAALNAHPDVEFAATLGYESPAETR-LASHVLVGAGADR------DPAALLAFLRQALP 6769 Query 897 EYMLPAAYVVLDEIPITAHGKIDRAALPEPQI---ASDTEFRAPQTATERRLAQLFGELL 953 YM+P+A V LD IP+T +GK+DR ALP P A + +R P+ E+ +A F E+L Sbjct 6770 GYMVPSALVFLDTIPLTPNGKLDRDALPAPDFGAAAKEIVYREPRNPLEQSIADAFAEVL 6829 Query 954 GRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI-----D 1008 G +G D FFD GG+SL AT++ A V + V VR++FE TV ALA + + Sbjct 6830 GGTDIGLDTDFFDAGGNSLSATRVTARVGALLDIRVTVRDLFEAPTVLALAESLAPRMSE 6889 Query 1009 TLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFA 1068 D SA P L + LS +Q R WF +F+ + N+P A L GP DT A A Sbjct 6890 AGDGASAGPALAPQPRPDRIPLSLAQQRMWFLNQFETSSPAYNLPAAVRLTGPLDTAALA 6949 Query 1069 AAITDVVARHEILRTVYREIGGVPHQIIQPPAE-----VPVRCAAGSDAAWLRAELNNER 1123 AAI D++ RHE LRTV+ + G PHQ+I P + PVR + LRA+L Sbjct 6950 AAIDDLITRHESLRTVFPDSRGGPHQVILEPGQFTPDTAPVRVSESG----LRADLEQFL 7005 Query 1124 GYVFDLETDWPIRAALLSTPE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRP 1182 FD+ P+R + S + + VL+ VVHHIA D S L D++ AY +R+ G P Sbjct 7006 LTGFDVSQAVPLRVKVYSLGDTEHVLAFVVHHIAADGVSMEPLIRDVMIAYSSRAAGHAP 7065 Query 1183 SWAPLPVQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALL 1239 SWAPLPVQYADY++WQ +L D + Q +YW R L G+ + L D RPA+ Sbjct 7066 SWAPLPVQYADYALWQREVLGVESDPGSLAAAQLEYWTRTLAGVPDQLYLPGDRGRPAVP 7125 Query 1240 SGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGR 1299 S G A F L A LA ++R G + FM+ AA++V+L + D+ +G +AGR Sbjct 7126 SHRGAATRFTLDADTHRALAELARAHGASIFMVAHAALSVLLGRLSTSSDITVGTAIAGR 7185 Query 1300 SEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQ 1359 LD +IG F+N +VLR L + +L++ R + L A+AH DLPF+++VE ++P Sbjct 7186 GRVELDDIIGMFVNTLVLRTTLDPGASFVSLLEQARDVDLEAFAHADLPFERLVEVLSPV 7245 Query 1360 RSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEP-TFDAAQADLSVNFFAC--- 1415 RS S +PLF + + V+ +D LEP T DA+ A ++F Sbjct 7246 RSTSHHPLFQVALGVQAVSADRLELDG--------LSLEPLTLDASTAKFDLHFTLTERL 7297 Query 1416 --GDEYRG---HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMV 1463 E G ++Y T++++ +TA +A L R+ EA P +P+ ++ ++ Sbjct 7298 DDASEAAGIDAELVYATDIFDESTAAEYAIRLRRIFEAVVADPQRPIGDIPVL 7350 Score = 713 bits (1841), Expect = 0.0, Method: Compositional matrix adjust. Identities = 499/1446 (35%), Positives = 723/1446 (50%), Gaps = 68/1446 (4%) Query 70 TQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAW 129 T DL+ + LE L APF+LS LR+ +VRT AD H L + HHI Sbjct 3798 TVVDLSGRESDSGERELESLVAENRTAPFDLSEAPLLRLLLVRTGADRHELAMTNHHILL 3857 Query 130 DDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLEL 189 D S + DL Y+ A + L P RP T D + RA A E + Sbjct 3858 DGWSIPLIVQDLLVLYATAGDQSAL-PAVRPYREYLDWLTRRDPSASRAAWAHALEGFDE 3916 Query 190 P---GPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTH 246 P PA T + + A A + A+ G TP V+ A+ L+ R T Sbjct 3917 PTLLAPAHTGGSATADPEEVPVHFSAADTAELLAFARQHGVTPNTVIQTAWALLLRRLTG 3976 Query 247 SDDFLVAAPVLNRGA---GTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAH 303 DD + A V R G E +G F NTV +R+R + S ELL + + H Sbjct 3977 RDDVVFGATVSGRPPHIPGIESMVGLFINTVPVRVRIDADESVAELLVRVQGQQADLLDH 4036 Query 304 QRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP----PGIECERYDLRSNITQ 359 + L E+ + GA T F D G+ + + S +T Sbjct 4037 HYLGL----TEIQAEAGVGALFDTLTVFESYPMDQAALQAQTDIAGMRVDSVQVHS-VTH 4091 Query 360 LPLGFMVEFD---RAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLAL 416 PL M + D R GV +L + E A+ + ++ +A P ++ + Sbjct 4092 YPLSLMAQVDDTLRLGV----AYLPDTFERDEARLIAARLDSVIRALIAEPSAAVAQVTG 4147 Query 417 MDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNR 476 + AR+ P TL+ L Q RTPDA AV ++G TY L+ +N+ Sbjct 4148 FIPGEYARVMHDWNATGHHVPESTLLTLFEAQAARTPDAVAVDFDGDVLTYAALDARANQ 4207 Query 477 LGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCD 536 L LI G+ E RVAV++ +S +L+V V+K+G YVPVDP +P +R ++LA Sbjct 4208 LARHLIALGVAPETRVAVVMRRSLELVVGIYAVLKAGGAYVPVDPDHPAERTSYVLASAQ 4267 Query 537 AKLVL-----------RTPVR-----ELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTT 580 VL R PV +L+G + TDA+RI PLRP + AY+IYTSG+T Sbjct 4268 PVCVLTTSADRPDLPNRIPVSALDTLDLSGVSAVPLTDAERIEPLRPAHPAYVIYTSGST 4327 Query 581 GLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIP 640 G PKGVAVPH + +W + EY + D D LQ + +FDVS+ F L GA MV+ Sbjct 4328 GKPKGVAVPHAAIVNQLLWMQSEYALTDRDVWLQKTATTFDVSLWGYFWPLQVGATMVLA 4387 Query 641 RPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVA 700 P G + YLT ++ + +T FVPS+L +F++ R+L+ V + GE LP Sbjct 4388 TPDGHREPAYLTRVIDERAVTVTDFVPSMLDVFVAAAPEGTCRSLRLVFVIGEALPPATV 4447 Query 701 DKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVP 760 +F A LHN YGPTE ++ + +K G T VPIG P+ NT ++LD L PVP Sbjct 4448 LRFRELSAAGLHNLYGPTEAAVSVTYWK-TGDADTTNVPIGVPEWNTQAYVLDSRLHPVP 4506 Query 761 TGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-PGSRMYRSGDLARRNADGDIEFVG 819 GV GE+Y+GG +A GY R LT++RFVA+PF G RMYR+GDL R + G + ++G Sbjct 4507 VGVPGELYLGGAQLARGYLGRVDLTSDRFVANPFGRTGERMYRTGDLVRWTSSGALVYIG 4566 Query 820 RADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPAD 879 R D QVK RG RIELG++ + P V AVV V +G LV YV G Sbjct 4567 RTDFQVKFRGQRIELGEIETVLRSHPAVTGAVVSVYSDTTVGDHLVAYVVGTPG------ 4620 Query 880 VGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQI-ASDTEFRAPQ 938 +D+ +R + + +LP YM+P+A VLDE P+ GK+DR LP P+ S TE+ AP+ Sbjct 4621 -ELDVAELRRQASESLPSYMVPSAITVLDEFPLNTSGKLDRKELPAPEFHGSSTEYIAPR 4679 Query 939 TATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFA 998 ER +A +F ++LG RVGA D+FFDLGG+SL T++ A + G + VR++F Sbjct 4680 NEAERTVAAVFADVLGSSRVGAHDNFFDLGGNSLSVTRVAARLGELSGTGLSVRDVFTAP 4739 Query 999 TVTALAGHI-DTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAA 1057 TV LA + + + ARP L+ + + LS +Q R WF +FD + N+PFA Sbjct 4740 TVAELARRLAEPTAAGGARPVLSGMQRPARIPLSPAQQRMWFINQFDPSSPAYNLPFAVR 4799 Query 1058 LHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAE--VPVRCAAGSDAAWL 1115 + G D A + A+ DVV RHE LRTV+ + P Q++ A+ +P+ + L Sbjct 4800 MSGALDVAALSQALDDVVGRHESLRTVFPDTDDGPAQVVVSAADLSMPLEVVDVPEGE-L 4858 Query 1116 RAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYR 1174 + + + FD+ D P+RA L T P + VL++ +HHIA D WS G L D++ AY Sbjct 4859 DSRMIAFSSHGFDVSEDLPVRATLFRTGPGEHVLAITLHHIAADGWSFGPLGADVMVAYA 4918 Query 1175 ARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRP 1231 AR+ + P W PL VQYADYSVW A+L D+ + Q +YW R L GL E L Sbjct 4919 ARAESRSPEWIPLAVQYADYSVWHRAVLGSEDEPESLARRQLEYWTRTLDGLPDELKLPF 4978 Query 1232 DFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVP 1291 D PR S G +V F + I + ++R+ G T FM+ AA A++L + D+ Sbjct 4979 DRPRRTEQSYVGGSVGFTITPEIHSGIERLAREHGATVFMVAHAAFALLLARLSASDDIA 5038 Query 1292 IGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQ 1351 +GAP+AGR E LD L+G F+N +VLR + T E+L R R + A+ H DLPF++ Sbjct 5039 VGAPIAGRGERALDNLVGMFVNTLVLRTRIESTETFAELLTRVRDGDIGAFGHADLPFER 5098 Query 1352 VVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVN 1411 +V+ ++P R+ + +P+ + + Q ID +RV + A+ DL + Sbjct 5099 LVDVLDPVRTSAHHPVIQTALSM-----QPTAIDDIELPGLRVRVEDIDARVAKFDLQLT 5153 Query 1412 FFACGDE------YRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSA 1465 D R Y +L++ T +R+A LVR++E P + +V ++ Sbjct 5154 LGEDIDPAGVPSGIRAEFTYAADLFDDVTVRRYAGQLVRILETVIADPTTVVGDVNLLDD 5213 Query 1466 QARRRI 1471 R R+ Sbjct 5214 AERARL 5219 Score = 615 bits (1585), Expect = 3e-173, Method: Compositional matrix adjust. Identities = 507/1538 (33%), Positives = 730/1538 (48%), Gaps = 101/1538 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARR--HRILRTTYPVGDDGV-- 56 MWF Q DP + I + G +D+A L +++ R LR V DGV Sbjct 52 MWFAQQLDPE-VPVTIAQCVELVGVLDVALLSESLITAGRELGSAFLRL---VEVDGVPY 107 Query 57 --AQPTVHADLRPGWTQYDLTDLSQRAQ-RLRLEVLAQREFCAPFELSRDAPLRITVVRT 113 PT+ A +R DL + R + ++E+ P ++ RD + V+ T Sbjct 108 QLVDPTLDASVR-------FVDLQREPDPRAAAKEWMRQEYTTPLDVCRDRLVTSAVLCT 160 Query 114 AADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADL 173 D H HH+A D TQ Y+ A G P AA+ D D Sbjct 161 GPDRHYWYSRVHHVALDGMGSMTLIDRTTQLYTAAVQGRTAAPS---KAAALTDVARVDD 217 Query 174 NY-----WRAIMADPPEPLELPGPAGTCV----PTSWRAARATLRLPADTAARVATMAKN 224 +Y +RA E + G + V P R+ A ++P + Sbjct 218 DYRISPRYRADQEYWSERVSTIGETHSLVERSAPARARSRTAGGQIPGTLVDHLEAATDR 277 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSA 283 + ++AAF A + R T ++ V+ PV R A + G N V + L + Sbjct 278 HDSSTAFEVIAAFAAYLSRMTGREEVAVSLPVTARTTALLRRSGGMVSNVVPLHLHVRPD 337 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 M+ +L+ A R + A HQR + R+ + + + V E G Sbjct 338 MTNADLVAAVRLEVTAALRHQRYPHIDIRRDAATEHQGFYGPLINVMLFHDEITLGSI-- 395 Query 344 PGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEH------LVEILEPALAKQMLRHFG 397 R +L S L V AG + + E A + R G Sbjct 396 ----VGRLELLSTGPITDLAVNVYHGVAGTSLNLDFEANPDLYSEGTLRAHHTRFTRFLG 451 Query 398 VLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA 457 L + P + L ++D+ D +R + G PV TL DL+ D A Sbjct 452 AFLTSDTDEP-RRVGDLDILDD-DESRTLVPASGRAGFAPV-TLPDLLGGAVRSNRDGDA 508 Query 458 VVYEGQ------HFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVK 511 +V G +Y L+EASNRL LI+ +G E VA+ L +S + + + V K Sbjct 509 LVAPGHGISSADTLSYRALDEASNRLARLLIDLQVGPEVMVALALPRSRESVSSVWAVAK 568 Query 512 SGAVYVPVDPSYPQDRLDFILADCDAKL-----VLRTPVREL---------------AGY 551 +GA +VPVDPS P DR+ F+L DC A + LR + E A Y Sbjct 569 AGAAFVPVDPSLPADRIAFMLEDCGAPIGITTAALRDGLPECTHWIVLDDDEFRATAAAY 628 Query 552 RSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDR 611 D TD DR R L D+ AY+IYTSG+TG PKGVAV HR V + V R Sbjct 629 PPDAVTDTDRTRALSVDHPAYVIYTSGSTGRPKGVAVTHRGVVNLAADERDRLVVSSGSR 688 Query 612 LLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLG 671 +L ASPSFD S+ E+ + GA +V+ P + L L+ ++ +T P+ L Sbjct 689 VLHFASPSFDASVFELVMAVCAGATLVVA-PTTIYGGTELAELMAEQRVTHAFCTPAALA 747 Query 672 LFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVG 731 L G+ RT V + G+ P E+ ++ ++ N YGP+ET I +S + Sbjct 748 -SLDHRGLDHLRT---VVVAGDVCPPELVARWAP--GRIMVNAYGPSETTIMSSATGPMV 801 Query 732 PQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVA 791 P + V +G P + + +LD L+PVP GV GE+Y+ G+ +A GY RRAGLTAERFVA Sbjct 802 PG--QPVTVGSPTVGVDLVVLDHRLRPVPAGVRGELYVLGSSLARGYVRRAGLTAERFVA 859 Query 792 DPFNPGSRMYRSGDLARRNADGD----IEFVGRADEQVKIRGFRIELGDVAAAIAVDPTV 847 PF G RMYR+GD+ R D +EF+GR+D QVKIRGFRIELG++ AA+ P V Sbjct 860 SPFGTGGRMYRTGDVVRWVTAPDGPPVLEFLGRSDFQVKIRGFRIELGEIDAALTAHPVV 919 Query 848 GQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVL 907 A V D LV YV P D V+ + V LP YM+P++ ++L Sbjct 920 EFAYTVGYDDGSGSSRLVSYVLPVPATD------VETRVLSEFVGERLPGYMVPSSIMML 973 Query 908 DEIPITAHGKIDRAALPEPQIAS-DTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFD 966 D +P+T GK+DR ALP P A+ + P+T TE L +F ++LG + D SFF+ Sbjct 974 DSLPLTPAGKLDRNALPAPVFAARSADIVRPRTVTEEILLGIFRDVLGLPELSVDTSFFE 1033 Query 967 LGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALA-GHIDTLDSDSARPRLTRVDHD 1025 LGG+SL+AT++V+ V A GV +GVR++F+ +V+ LA +T +RP L + Sbjct 1034 LGGNSLMATQVVSRVNTALGVRIGVRDLFQSPSVSQLAVPAANTGPQADSRPVLEARERP 1093 Query 1026 GPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVY 1085 V LS +Q R WF +FD + N+P + L G D A AA+ DV RHE LRTV+ Sbjct 1094 DHVPLSVAQQRMWFLNQFDTASPAYNLPISLRLTGALDREALRAALGDVQERHEALRTVF 1153 Query 1086 REIGGVPHQIIQPPAEVPVRC-AAGSDAAWLRAELNNERGYVFDLETDWPIRAALL-STP 1143 + PHQ++ P V DA L A + G FDL TD P+RA L P Sbjct 1154 PDTPDGPHQLVVPVVSVLAETDPIDVDAKSLTAAVTALGGAGFDLTTDTPLRAGLFREAP 1213 Query 1144 EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL- 1202 ++ VL LVVHH+A D WS L D++ AY AR G P+WAPLPVQYADY++WQ LL Sbjct 1214 DRHVLVLVVHHVAADGWSMTPLAADVMVAYAARVAGHAPTWAPLPVQYADYTLWQRELLG 1273 Query 1203 --DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 DD + Q +W L G+ L D PRPA +S G VEF + A + +L Sbjct 1274 SEDDPDSVSARQIAHWQSALAGVPQLLELPADRPRPAEMSHRGGRVEFTITADVHGRLVD 1333 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 +++ G T FM+ AA+ V+ H+ G G D+ IG PVAGR E LD L+G F+N +VLR Sbjct 1334 LAQSTGTTLFMVTHAALVVLFHRLGAGTDIVIGTPVAGRGEEALDDLVGMFVNTLVLRAT 1393 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 T EVL R R LAA++H D+PF+++VE ++P RS +R+PLF +++ + P Sbjct 1394 AEPGDTFEEVLDRVRDADLAAFSHADVPFERLVEVLSPDRSAARHPLFQVMLSFQNTAPT 1453 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACG--DEYRGHVIYRTELYERATAQRF 1438 + + V FD Q ++ F G Y T+L++ +T Sbjct 1454 SVELPGLEVAAAEIDVHVAKFD-LQLTVTERFVGAGMPGGLAAGFDYATDLFDESTVASM 1512 Query 1439 ADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 A+ ++ + A + ++ ++ A R R+L N Sbjct 1513 AERFANLLRSVAASSATVVGDLSLLHAAERDRLLGTWN 1550 Score = 585 bits (1508), Expect = 2e-164, Method: Compositional matrix adjust. Identities = 375/1053 (36%), Positives = 550/1053 (53%), Gaps = 58/1053 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ DP+ A+ NI + R++G +D+ L+ AV V RRH LRT YP DG Q Sbjct 9043 MWFLNRFDPNSAVHNIPAAVRLSGALDVDALQHAVADVVRRHESLRTVYPDSADGPHQVI 9102 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + D G TD + L L F+++ + P+R+ + R +A EHVL Sbjct 9103 LPIDRVGGEMSVVATDEAA------LPALIAGLVTTGFDVTTEVPVRVRIFRMSATEHVL 9156 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP----------------SAAS 164 LV HHI+ D S D+ AY A AD P+ P + Sbjct 9157 ALVVHHISGDGWSMAPMVRDVMTAY--AARSADTTPDWAPLPVQYADYALWQRALLGDET 9214 Query 165 GPDTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 P++ A L +W +A P+ L+LP S+R +PAD + A+ Sbjct 9215 DPESVSARQLAFWTHTLAGAPDQLDLPTDRPRPAVASYRGGTVDFTVPADLHGTLLGAAR 9274 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQS 282 + + +M++ AA L+ R + + D + PV RG +D IG F NT+ +R + Sbjct 9275 DANASLFMLVHAALAVLLSRLSGTGDIAIGTPVAGRGERELDDLIGMFVNTLVLRQQVDG 9334 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 +F EL+ R+ AF+H + +R+V +NP R G + +V F+ D Sbjct 9335 GRTFAELVADVRETDLAAFSHADVPFERLVEVVNPSRSTGRHPLFQVMLTFQNLDQATLR 9394 Query 343 PPGIECERYDLRSNITQ--LPLGFMVEFDRAG----VLVEAEHLVEILEPALAKQMLRHF 396 + D +I + L L M +FD AG + + ++ + + F Sbjct 9395 LGDLSVSGVDFDVDIAKFDLQLTLMEQFDSAGSPDGIAARLTYASDLFDEPSMHVFGQRF 9454 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDAT 456 +L A +PD + + ++ + ++ + + P TL L + + P Sbjct 9455 QQVLRAATDSPDTAVGDIDVLGSGERKQIAG-TNATSHEVPAGTLASLFDTRVAADPVRV 9513 Query 457 AVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVY 516 AV+++ TY D + NRL LIEQG+G E VAV + +S DL+V VVK+G Y Sbjct 9514 AVIFDRDELTYADFDARVNRLARRLIEQGVGPESVVAVAMRRSIDLLVAIYAVVKAGGAY 9573 Query 517 VPVDPSYPQDRLDFILADCDAKLVLRT----------PV-----RELAGYRSDDPTDADR 561 +PVDP +P +R +L VL + PV +++G+ S TDADR Sbjct 9574 LPVDPDHPAERTAHVLDTAQPACVLVSGAGLAGGGSVPVIDVASEDVSGFDSSPVTDADR 9633 Query 562 IRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFD 621 + PL P NTAY+I+TSG+TG PKGVAV H + +W + EY + D +LQ +FD Sbjct 9634 LWPLSPANTAYVIFTSGSTGRPKGVAVTHGAIVNRLLWMQHEYTLTSADVVLQKTPVTFD 9693 Query 622 VSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQ 681 VS+ E+F L GA +VI P G D YLT L+++ +T HFVPS+L +F + P V+ Sbjct 9694 VSVWELFWPLQVGASLVIAAPDGHRDPRYLTGLIQERHVTTTHFVPSMLSVFTAEPAVAV 9753 Query 682 WRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIG 741 +L+ V GE L E +F A A LHN YGPTE ++ + ++ G T VPIG Sbjct 9754 CDSLRLVFCSGEALTPEQVSRFRAVCGADLHNLYGPTEAAVDVTYWE-TGAADTVTVPIG 9812 Query 742 RPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMY 801 RP NT +H+LD L PVP GV GE+Y+ G +A GY R L+A+RFVA+P G RMY Sbjct 9813 RPVWNTQVHVLDSRLHPVPNGVAGELYLAGDQLARGYLNRPDLSADRFVANPHVAGGRMY 9872 Query 802 RSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLG 861 R+GDL RR ADG +E+VGR D QVK+RG RIELG++ AA+ P V QAVVVV R Sbjct 9873 RTGDLVRRRADGVLEYVGRTDFQVKLRGQRIELGEIEAALEAHPDVSQAVVVVHRDDRGE 9932 Query 862 KSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRA 921 ++LV Y+ GP D +RA ++A +P YM+PA V LD +P++A+GK+DR Sbjct 9933 EALVAYLV------GPR--AADWSDVRAHLSARVPSYMIPAQVVHLDTLPLSANGKLDRT 9984 Query 922 ALPEPQIASDT-EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAA 980 ALP P S E++AP+TA ER +A +F ++LG DRVG DSFFDLGG+SL+AT++ +A Sbjct 9985 ALPAPAARSAADEYQAPRTAAERAVATVFADVLGIDRVGVTDSFFDLGGNSLIATRVASA 10044 Query 981 VRNAFGVDVGVREIFEFATVTALAGHIDTLDSD 1013 + + G+D ++ +F T +L I +D Sbjct 10045 LGSELGIDFPLQWMFSDPTPQSLGQRIQKWTND 10077 Score = 539 bits (1389), Expect = 1e-150, Method: Compositional matrix adjust. Identities = 368/1053 (35%), Positives = 531/1053 (51%), Gaps = 55/1053 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWFV D + A N+ + R++G +D LR A+ V RH LRT YP DG Q Sbjct 2167 MWFVNQFDTASAAYNMPFALRLSGILDCDGLRSAIRDVLERHESLRTLYPDSTDGPHQVI 2226 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V AD P D+ +++ RL LA F +++ PLR ++R + DE+VL Sbjct 2227 VGADEVP--LDLDVQPITEAELPTRLVELATEGF----DVTSAVPLRTALLRLSVDEYVL 2280 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLG---PEHRPSAASG 165 +V HHI+ D S D+ AY+ G AD E G Sbjct 2281 AVVVHHISADGSSMAPLARDILLAYTARTAGRAPSWPPLDVQYADYSYWQAEFLGDETDG 2340 Query 166 PDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 + +W A + P+ LELP + A + A TA VA +A + Sbjct 2341 RSQATEQIEFWSAALDGIPDLLELPADRPRPAMPTNSGATVPFSVDAATAKAVADLAARS 2400 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGT-EDAIGYFGNTVAMRLRPQSAM 284 TP+MV AA L+ R +++ D V PV R + +D +G F NT+ +R R + Sbjct 2401 AATPFMVWHAALSVLLSRLSNAVDVTVGTPVAGRAEPSLQDLVGMFVNTLTLRARVSGDL 2460 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 SF +LL R+ AFAH + +R+V L P R + +V + + G P Sbjct 2461 SFADLLAQVREFDLAAFAHADLPFERLVEVLEPARSTARHPLFQVGLSYENFEPGVLELP 2520 Query 345 GIECERYDLRSNITQLPLGFMVEFDR------AGVLVEAEHLVEILEPALAKQMLRHFGV 398 G+ ++ I + L + R +G+ + V++ + + F Sbjct 2521 GLTVSAVEMNPEIAKFDLNVTLTEIRDERGTVSGLTGAFTYAVDLFDRDTVESFADRFAR 2580 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV 458 ++ ALA P + L ++D+R+ R+ + + + +EQ RTPDA AV Sbjct 2581 IVTAALADPGTAVGDLPVLDQRELVRVLREWNATDVEVSGRPYLARYDEQAARTPDAVAV 2640 Query 459 VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVP 518 VY TY + N NRL LI +G G+E VAV +S + ++ V++SGA YVP Sbjct 2641 VYRDVSVTYREFNSRVNRLARKLIAEGAGTETTVAVAARRSIEFLIALHAVLRSGAAYVP 2700 Query 519 VDPSYPQDRLDFILADCDAKLVLRT--------------PVRELAGYRSDDP--TDADRI 562 +D P +R+ ++ LVL P+ L R DD T+ DR+ Sbjct 2701 LDVDLPAERVAHVIEAAHPVLVLTAVRGEFESDSGVRVLPIDGLELDRFDDAPVTNRDRL 2760 Query 563 RPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDV 622 RPL DN AY+I+TSG+TG PKGVAV H + +F + +D+TDR++ SFD Sbjct 2761 RPLAADNLAYVIFTSGSTGRPKGVAVSHAGLGSHFEFLMSLCALDETDRVVVKTPQSFDA 2820 Query 623 SIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQW 682 S+ E+ LA GAR+VI P G D YL L+ E ITA+HFVPS+L +F + S++ Sbjct 2821 SLWELLWPLAVGARVVIAEPDGHKDPDYLAELIDTEQITAIHFVPSMLAVFTDVIAPSRF 2880 Query 683 RTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGR 742 +L+ V +GGE L VA +F A DA + N YGP E V AS V + IV +G Sbjct 2881 SSLRTVFVGGEALSVNVARRFAAVSDAAVLNAYGPAE-VAAASTTSWVDTSNSAIVTVGT 2939 Query 743 PKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-PGSRMY 801 P NT ++LD L P P GV GE+Y+ GT V+ GY R LTAERFVA+PF+ PG+RMY Sbjct 2940 PVWNTRAYVLDQRLHPSPAGVTGELYLAGTQVSRGYAGRPDLTAERFVANPFDAPGTRMY 2999 Query 802 RSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLG 861 R+GD R G++E++GR D QVK+RG RIELG++ A + +V QAVV V Sbjct 3000 RTGDRLRWTGRGELEYLGRNDFQVKLRGLRIELGEIEAVLESADSVAQAVVTVYS-GAAS 3058 Query 862 KSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRA 921 + LV Y+ AG VD++ + A A+ LPEYM+P +V LD P+ A GK+DR Sbjct 3059 EQLVAYLVARAG------TRVDIEALTAYAASRLPEYMVPDGFVTLDAFPLNASGKLDRV 3112 Query 922 ALPEPQIASDTEFRA-PQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAA 980 ALP P + R P+T E LA LF E LG D +G +DSFF LGG S+++ +LV+ Sbjct 3113 ALPAPAVGDVAVDRVEPRTPMEESLAALFREALGVDDLGVNDSFFALGGDSIVSIQLVSR 3172 Query 981 VRNAFGVDVGVREIFEFATVTALAGHIDTLDSD 1013 + A G+ R++FE ++ ALA + +D Sbjct 3173 AKAA-GIVFTPRDVFERKSIAALAEVVTVASAD 3204 Score = 68.9 bits (167), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 41/100 (41%), Positives = 53/100 (53%), Gaps = 8/100 (8%) Query 1463 VSAQARRRILDRSNAGAGT-------ARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLA 1515 V+A + +D SN+ T R Y+LD L P P GV G++Y G Sbjct 2918 VAAASTTSWVDTSNSAIVTVGTPVWNTRAYVLDQRLHPSPAGVTGELYLAGTQVSRGYAG 2977 Query 1516 RPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELL 1555 RP TA RFVA+PF A PG+R+YR G+R W G+LE L Sbjct 2978 RPDLTAERFVANPFDA-PGTRMYRTGDRLRWTGRGELEYL 3016 Score = 62.0 bits (149), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 32/77 (42%), Positives = 45/77 (59%), Gaps = 1/77 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R +LD L+PVPVGV G++Y GG L RP TA RFVADP+ +PG +YR G+ Sbjct 7690 RALVLDGRLRPVPVGVPGELYVGGPSLARGYLGRPGLTAERFVADPY-GEPGDLMYRTGD 7748 Query 1543 RGVWKADGQLELLAEIE 1559 W+ + L+ + + Sbjct 7749 LVRWRENRVLDFVGRTD 7765 Score = 61.6 bits (148), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 35/78 (45%), Positives = 45/78 (58%), Gaps = 1/78 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVPVGV G++Y G +AR TA RFVA+PF A GSRLYR G+ Sbjct 8754 QVFVLDARLNPVPVGVAGELYLAGEQLARGYVARADLTAERFVANPFGAS-GSRLYRTGD 8812 Query 1543 RGVWKADGQLELLAEIER 1560 W +L +ER Sbjct 8813 VVRWHVRDSRGVLEYLER 8830 Score = 59.7 bits (143), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 32/77 (42%), Positives = 43/77 (56%), Gaps = 2/77 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +VY+LD L PVP GV G++Y G L R T+ RFVA+PF PG R+YR G+ Sbjct 1883 QVYVLDSRLHPVPPGVAGELYLAGEQLARGYLGRVDLTSDRFVANPF--TPGLRMYRTGD 1940 Query 1543 RGVWKADGQLELLAEIE 1559 W + G LE + + Sbjct 1941 LVRWTSAGALEYIGRTD 1957 Score = 59.7 bits (143), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 31/70 (45%), Positives = 41/70 (59%), Gaps = 1/70 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 + Y+LD L PVPVGV G++Y GG L R T+ RFVA+PF + G R+YR G+ Sbjct 4494 QAYVLDSRLHPVPVGVPGELYLGGAQLARGYLGRVDLTSDRFVANPF-GRTGERMYRTGD 4552 Query 1543 RGVWKADGQL 1552 W + G L Sbjct 4553 LVRWTSSGAL 4562 Score = 59.3 bits (142), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 109/450 (25%), Positives = 176/450 (40%), Gaps = 49/450 (10%) Query 1025 DGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTV 1084 DG LS++Q WF + D P I L G D + ++ + A E+ Sbjct 40 DGAFPLSTAQRGMWFAQQLD-PEVPVTIAQCVELVGVLDVALLSESL--ITAGRELGSAF 96 Query 1085 YR--EIGGVPHQIIQPPAEVPVRCA--------AGSDAAWLRAELNNERGYVFDLETDWP 1134 R E+ GVP+Q++ P + VR + W+R E D+ D Sbjct 97 LRLVEVDGVPYQLVDPTLDASVRFVDLQREPDPRAAAKEWMRQEYTTP----LDVCRDRL 152 Query 1135 IRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYAD 1193 + +A+L T P++ VHH+A D + L Y A G+ + P + A Sbjct 153 VTSAVLCTGPDRHYWYSRVHHVALDGMGSMTLIDRTTQLYTAAVQGRTAA----PSKAA- 207 Query 1194 YSVWQSALLDDGAGIVGPQR---DYWIRQLGGLAGETG--LRPDFPRPALLSGAGDAVEF 1248 ++ A +DD I R +YW ++ + GET + P A AG + Sbjct 208 -ALTDVARVDDDYRISPRYRADQEYWSERVSTI-GETHSLVERSAPARARSRTAGGQIP- 264 Query 1249 RLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLI 1308 G + AA R T F ++ AA A L + G +V + PV R+ A L + Sbjct 265 --GTLVDHLEAATDRHDSSTAFEVI-AAFAAYLSRMTGREEVAVSLPVTARTTALLRRSG 321 Query 1309 GFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLF 1368 G N+V L +R + T +++ R AA HQ P + + PL Sbjct 322 GMVSNVVPLHLHVRPDMTNADLVAAVRLEVTAALRHQRYPHIDIRRDAATEHQGFYGPLI 381 Query 1369 DIVVHVRE-----QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHV 1423 ++++ E + + ++ TGP D + V A L+++F A D Y Sbjct 382 NVMLFHDEITLGSIVGRLELLSTGPITDLAVNVYH---GVAGTSLNLDFEANPDLY---- 434 Query 1424 IYRTELYERATAQRFADWLVRVVEAFADRP 1453 +E RA RF +L + + D P Sbjct 435 ---SEGTLRAHHTRFTRFLGAFLTSDTDEP 461 Score = 58.5 bits (140), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/71 (47%), Positives = 48/71 (68%), Gaps = 1/71 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T TE A+AA+ ADVL V +VG +FF+LGG+S++AT+V AR + G + R +FE P Sbjct 8944 TPTEEAVAAVFADVLGVDQVGTAANFFDLGGNSLVATRVVARLSERLGCRVEIRTLFEAP 9003 Query 1635 VLCELAAAVDA 1645 + LAA +D+ Sbjct 9004 TVAALAALLDS 9014 Score = 58.2 bits (139), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/66 (49%), Positives = 43/66 (66%), Gaps = 1/66 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD-GGIPLTARMVFEHP 1634 E ER +AA+ ADVL VG +D+FF+LGG+S+ T+VAAR + G L+ R VF P Sbjct 4680 NEAERTVAAVFADVLGSSRVGAHDNFFDLGGNSLSVTRVAARLGELSGTGLSVRDVFTAP 4739 Query 1635 VLCELA 1640 + ELA Sbjct 4740 TVAELA 4745 Score = 56.2 bits (134), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 37/104 (36%), Positives = 54/104 (52%), Gaps = 8/104 (7%) Query 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG 1621 P AA E E +A I AD+L + E+G +D FF+LGG+S+LATQV +R Sbjct 7863 PIFVAAATTFEAPRNPMEVIVAGIFADILALPEIGIHDSFFDLGGNSLLATQVVSRINAA 7922 Query 1622 -GIPLTARMVFEHPVLCELAAAVDA-------KPHVEAEPDDKH 1657 + + R VFE P + LAA + +P + A+P +H Sbjct 7923 LDVHVGVREVFESPTVAALAARITETTTHGVRRPALTAKPRPEH 7966 Score = 56.2 bits (134), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 32/77 (42%), Positives = 44/77 (58%), Gaps = 2/77 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVP GV G++Y G L RP +A RFVA+P A G R+YR G+ Sbjct 9819 QVHVLDSRLHPVPNGVAGELYLAGDQLARGYLNRPDLSADRFVANPHVA--GGRMYRTGD 9876 Query 1543 RGVWKADGQLELLAEIE 1559 +ADG LE + + Sbjct 9877 LVRRRADGVLEYVGRTD 9893 Score = 55.5 bits (132), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 30/68 (45%), Positives = 41/68 (61%), Gaps = 0/68 (0%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPV 1635 T E +LAA+ + L V ++G D FF LGGDSI++ Q+ +RA+ GI T R VFE Sbjct 3131 TPMEESLAALFREALGVDDLGVNDSFFALGGDSIVSIQLVSRAKAAGIVFTPRDVFERKS 3190 Query 1636 LCELAAAV 1643 + LA V Sbjct 3191 IAALAEVV 3198 Score = 53.1 bits (126), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/63 (48%), Positives = 39/63 (62%), Gaps = 1/63 (1%) Query 1486 LLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGV 1545 +LD L+PVPVGVVG++Y G R + TA RFVA PF A G+R+YR G+ Sbjct 6615 VLDSRLRPVPVGVVGELYLLGPALARGYHERAALTAHRFVASPFEAA-GARMYRTGDIVR 6673 Query 1546 WKA 1548 W+A Sbjct 6674 WRA 6676 Score = 52.0 bits (123), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/70 (43%), Positives = 44/70 (63%), Gaps = 1/70 (1%) Query 1575 DTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEH 1633 DT E A+AA ADVL +G D+FF LGG+S+ ATQV +R G ++ R +F++ Sbjct 5739 DTADEIAVAAAFADVLGESRIGVDDNFFALGGNSLSATQVVSRVGSAFGTRVSVRTLFDN 5798 Query 1634 PVLCELAAAV 1643 P + +L +AV Sbjct 5799 PTVRQLVSAV 5808 Score = 51.2 bits (121), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/70 (40%), Positives = 45/70 (65%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T E LA I A+VL + +G D+FF++GG+S++AT+V +R R + G PL R +F+ P Sbjct 2069 TSVEANLAEIFAEVLGLDRIGLRDNFFDVGGNSLVATRVTSRIRAELGAPLALRDLFDAP 2128 Query 1635 VLCELAAAVD 1644 + LA ++ Sbjct 2129 TVGALAERIE 2138 Score = 49.7 bits (117), Expect = 0.005, Method: Compositional matrix adjust. Identities = 30/74 (41%), Positives = 44/74 (60%), Gaps = 1/74 (1%) Query 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVA-ARARD 1620 P A++A + T ERA+A + ADVL + VG D FF+LGG+S++AT+VA A + Sbjct 9989 PAARSAADEYQAPRTAAERAVATVFADVLGIDRVGVTDSFFDLGGNSLIATRVASALGSE 10048 Query 1621 GGIPLTARMVFEHP 1634 GI + +F P Sbjct 10049 LGIDFPLQWMFSDP 10062 Score = 49.3 bits (116), Expect = 0.006, Method: Compositional matrix adjust. Identities = 32/96 (34%), Positives = 50/96 (53%), Gaps = 7/96 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T TE L I DVL + E+ FF LGG+S++ATQV +R G+ + R +F+ P Sbjct 1006 TVTEEILLGIFRDVLGLPELSVDTSFFELGGNSLMATQVVSRVNTALGVRIGVRDLFQSP 1065 Query 1635 VLCELAA-AVDAKPHVEAEP-----DDKHHAPMSTS 1664 + +LA A + P ++ P + H P+S + Sbjct 1066 SVSQLAVPAANTGPQADSRPVLEARERPDHVPLSVA 1101 Score = 46.6 bits (109), Expect = 0.042, Method: Compositional matrix adjust. Identities = 26/63 (42%), Positives = 34/63 (54%), Gaps = 2/63 (3%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 + +LD L+PVP GV G++Y G + R TA RFVA PF G R+YR G+ Sbjct 817 LVVLDHRLRPVPAGVRGELYVLGSSLARGYVRRAGLTAERFVASPFGT--GGRMYRTGDV 874 Query 1544 GVW 1546 W Sbjct 875 VRW 877 Score = 43.9 bits (102), Expect = 0.25, Method: Compositional matrix adjust. Identities = 33/93 (36%), Positives = 43/93 (47%), Gaps = 3/93 (3%) Query 1456 PLREVEMVSAQARRRILDRSNAGAGTARV--YLLDDALKPVPVGVVGDVYYGGGPAVGAR 1513 P MV+ + +R GA V ++LD L PV GV G++Y G Sbjct 5521 PTESSMMVTQSGPLMLGERMTIGAPVRGVEAFVLDARLHPVSPGVPGELYISGPALARGY 5580 Query 1514 LARPSETATRFVADPFAAQPGSRLYRNGERGVW 1546 R TA RFVA+P A PG R+YR G+ W Sbjct 5581 HQRLGLTAERFVANPHGA-PGRRMYRTGDLVRW 5612 Score = 40.4 bits (93), Expect = 3.2, Method: Compositional matrix adjust. Identities = 33/106 (32%), Positives = 50/106 (48%), Gaps = 7/106 (6%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGG---IPLTARMVFEHPV 1635 E+++A A+VL ++G DFF+ GG+S+ AT+V AR G I +T R +FE P Sbjct 6818 EQSIADAFAEVLGGTDIGLDTDFFDAGGNSLSATRVTARV--GALLDIRVTVRDLFEAPT 6875 Query 1636 LCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSPDELSALTASWDQW 1681 + LA ++ P + D P PD + A W Sbjct 6876 VLALAESL--APRMSEAGDGASAGPALAPQPRPDRIPLSLAQQRMW 6919 >gi|291436402|ref|ZP_06575792.1| pstC [Streptomyces ghanaensis ATCC 14672] gi|291339297|gb|EFE66253.1| pstC [Streptomyces ghanaensis ATCC 14672] Length=4795 Score = 872 bits (2253), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/1585 (38%), Positives = 839/1585 (53%), Gaps = 102/1585 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ D +GA NI + ++ G++D L DA+ V RH LRT + D Q Sbjct 1066 LWFLGRFDTTGAGYNIPLVLQLDGELDRDALSDALTDVIARHESLRTVFAETDGRPHQVV 1125 Query 61 VHADLRPGWTQYDLTD--LSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 + +TD L R LA+ PF+L+ + PLR+T+ A H Sbjct 1126 LPPAPAAALRPVAVTDDDLDDR--------LAEAA-SLPFDLATETPLRVTLFALGARRH 1176 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP--------------SAAS 164 VLLL+ HHIA D S DL+ AY+ GA E P + Sbjct 1177 VLLLLLHHIAGDGWSLAPLARDLSTAYAARRSGATPAWEPLPVQYADYSLWQHELFGSED 1236 Query 165 GPDTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D+ A + +W+ ++A PE L LP S R L ++ +++ Sbjct 1237 DEDSVGARQIAHWKQVLAGLPEELALPTDRPRPAQASLRGDVVPFSLTPKLHRKLVQLSR 1296 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 ++ C+ +MVL A AL+ R +D + V R +D +G+F N + +R Sbjct 1297 DSRCSLFMVLQAGLAALLDRLGCGEDIPIGTAVAGRTDEALDDLVGFFVNNLVLRCDTSG 1356 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 SFRELL R+ A+AHQ ++ DR+V +NP+R + +V + + Sbjct 1357 DPSFRELLARVRETDLTAYAHQDVSFDRLVEVVNPERSLARHPLFQVMLTLQNTERATLE 1416 Query 343 PPGIECERYDLRSNITQLPLGFMVEFDRA------GVLVEAEHLVEILEPALAKQMLRHF 396 PG+ +R+ + L + R G+ E+ ++ + A ++ + + Sbjct 1417 LPGLSVAPRAVRTGSARFDLALELGEKRGADGGHDGLDGIVEYSTDLFDRATVEKFVSRY 1476 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDAT 456 LL+ A D + + ++ + L R + P TL L+ EQ RTPDA Sbjct 1477 VRLLEAVAADADRAIGRIDVLGPVERHELLVRRNDTRHEVPDTTLTGLLAEQAARTPDAP 1536 Query 457 AVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVY 516 A+V+E TY +L+ +NRL L+ +G+ E VAV + +SP+L+V L V+K+GA Y Sbjct 1537 ALVFEDTTLTYAELDARANRLARRLVAEGVRPERTVAVAVPRSPELVVALLAVLKAGAAY 1596 Query 517 VPVDPSYPQDRLDFILADCDAKLVL-------------RTPVRELAGYRSDDPTDADRIR 563 +PVDP YP DR+ +L + + L+L RTP L DD +R Sbjct 1597 LPVDPDYPADRIGHLLGEAEPALLLTVAAAGLPEQPDLRTPRLSL-----DDAGLIAELR 1651 Query 564 PL---------RPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQ 614 L RPDN AY+IYTSG+TG PKGV VPHR + +W + Y + DR+LQ Sbjct 1652 ALDASPLPDTARPDNPAYVIYTSGSTGRPKGVPVPHRGIVNRLLWMQDRYGLRADDRVLQ 1711 Query 615 VASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFL 674 FDVS+ E F L GA +V+ RP G D YL L+R E IT +HFVPS+L FL Sbjct 1712 KTPSGFDVSVWEFFWPLITGATLVLARPEGHRDPVYLAELIRAERITTLHFVPSMLQAFL 1771 Query 675 SLPGVSQW-RTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQ 733 + P + +L+RV GE L G+ +F FDA LHN YGPTE ++ + + + Sbjct 1772 AEPAAAGCGASLRRVICSGEALTGDQRSRFFDLFDAELHNLYGPTEASVDVTHWTCEPSE 1831 Query 734 GTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADP 793 R VPIG P NT +++LD +L+PV GV+GE+Y+ G +A GY R LTAERF A P Sbjct 1832 EARAVPIGHPVWNTRVYVLDAALRPVAPGVVGELYLAGEQLARGYLGRPALTAERFTACP 1891 Query 794 F-NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVV 852 + + G RMYR+GDL R +DG +E++GRAD QVK+RGFRIELG++ + + P V QA V Sbjct 1892 YGDAGGRMYRTGDLVRWGSDGALEYLGRADHQVKLRGFRIELGEIESVLVSHPDVAQAAV 1951 Query 853 VVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPI 912 +V + K LV Y PA D PA D +R +AAALPEYM+P+A+V LD +P+ Sbjct 1952 LVREDRPGDKRLVAYTVPA---DTPAP-DTDGGALRRHLAAALPEYMVPSAFVTLDALPL 2007 Query 913 TAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDR-VGADDSFFDLGGHS 971 T +GK+DR ALP P++ + RAP TA E L +LFGE+LG D GADDSFF+LGGHS Sbjct 2008 TPNGKLDRKALPAPEVQTGEPGRAPATAQEALLCRLFGEVLGLDAPAGADDSFFELGGHS 2067 Query 972 LLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLS 1031 LL T+L++ +R V++ +R +FE T LA + D+ AR L+RV + LS Sbjct 2068 LLGTRLISRIRGEVDVELPIRALFETPTPAGLARLLG--DARPARRALSRVPRPEHLPLS 2125 Query 1032 SSQMRSWFNYRFDGPNAVN-NIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGG 1090 +Q R WF R DG A N+P A L G D A AAA+ DVV RHE+LRTV+ + G Sbjct 2126 YAQQRLWFLSRLDGAEAATYNLPVAVRLTGVLDPAALAAALHDVVGRHEVLRTVFPDTDG 2185 Query 1091 VPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPE-QTVLS 1149 VPHQ + + R D LR L FDL TD P+RA L E + VL Sbjct 2186 VPHQRVLDACDA--RPEWAVDEKDLRTALGATAARGFDLATDLPLRATLFRAGEREHVLL 2243 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGA 1206 LV+HHIA D S G L DL AY AR G+ P+W LPVQYADY++WQ +L DD Sbjct 2244 LVLHHIAADGSSMGPLARDLSAAYAARCRGEAPAWNELPVQYADYALWQREVLGREDDPT 2303 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 +V Q D+W R L GL E L D PRPA S GD V F L A + LAA++R+ G Sbjct 2304 SVVSGQLDFWRRALAGLPEELPLPVDRPRPARASYRGDVVPFTLDADVHAGLAALARESG 2363 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 + FM+LQAAVAV L K G G DVP+G PVAGR+++ LD L+GFF+N +VLR D G+PT Sbjct 2364 ASLFMVLQAAVAVWLGKLGAGPDVPLGTPVAGRTDSALDDLVGFFVNTLVLRTDTSGDPT 2423 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 RE+L R R+ L AYAHQD+PF+++V+ V+P+RSL+R+PLF +++ + + Sbjct 2424 FRELLDRVRETDLEAYAHQDVPFERLVDLVSPERSLARHPLFQVMLTLDNDARGHLAL-- 2481 Query 1387 GPDGDTTLRVLEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYERATAQRFAD 1440 D +L AA+ DL+++F + G V + +L++R+T + F Sbjct 2482 ---ADVDAEILPLGTGAAKFDLALSFGERSADDGSPAGLDGFVDFAVDLFDRSTIEAFLG 2538 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVG 1500 L RV+ A A PD P+ V+++SA R +L N D PV G + Sbjct 2539 RLERVLRAVAADPDAPVGTVDVLSADERTDLLTTWN------------DTTAPVLTGTLP 2586 Query 1501 DVYYGGG---PAVGARLARPSETAT 1522 D++ PA A L+ ET T Sbjct 2587 DLFQAQAARTPAHTALLSADGETLT 2611 Score = 788 bits (2036), Expect = 0.0, Method: Compositional matrix adjust. Identities = 566/1523 (38%), Positives = 790/1523 (52%), Gaps = 89/1523 (5%) Query 1 MWFVQMAD-PSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQP 59 +WF+ D A N+ V+ R+TG +D A L A++ V RH +LRT +P DGV Sbjct 2131 LWFLSRLDGAEAATYNLPVAVRLTGVLDPAALAAALHDVVGRHEVLRTVFP-DTDGVPHQ 2189 Query 60 TV--HADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADE 117 V D RP W + ++ R L A R F +L+ D PLR T+ R E Sbjct 2190 RVLDACDARPEWA------VDEKDLRTALGATAARGF----DLATDLPLRATLFRAGERE 2239 Query 118 HVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASG 165 HVLLLV HHIA D S DL+ AY+ G AD R Sbjct 2240 HVLLLVLHHIAADGSSMGPLARDLSAAYAARCRGEAPAWNELPVQYADYALWQREVLGRE 2299 Query 166 PDTTE---ADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMA 222 D T L++WR +A PE L LP S+R L AD A +A +A Sbjct 2300 DDPTSVVSGQLDFWRRALAGLPEELPLPVDRPRPARASYRGDVVPFTLDADVHAGLAALA 2359 Query 223 KNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQ 281 + +G + +MVL AA + + D + PV R + +D +G+F NT+ +R Sbjct 2360 RESGASLFMVLQAAVAVWLGKLGAGPDVPLGTPVAGRTDSALDDLVGFFVNTLVLRTDTS 2419 Query 282 SAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGF 341 +FRELL R+ A+AHQ + +R+V ++P+R + +V G Sbjct 2420 GDPTFRELLDRVRETDLEAYAHQDVPFERLVDLVSPERSLARHPLFQVMLTLDNDARGHL 2479 Query 342 NPPGIECERYDLRSNITQLPLGFMV------EFDRAGVLVEAEHLVEILEPALAKQMLRH 395 ++ E L + + L + AG+ + V++ + + + L Sbjct 2480 ALADVDAEILPLGTGAAKFDLALSFGERSADDGSPAGLDGFVDFAVDLFDRSTIEAFLGR 2539 Query 396 FGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDA 455 +L A PD + + ++ + L TL DL Q RTP Sbjct 2540 LERVLRAVAADPDAPVGTVDVLSADERTDLLTTWNDTTAPVLTGTLPDLFQAQAARTPAH 2599 Query 456 TAVVY-EGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGA 514 TA++ +G+ TY LNE +NRL H LI++G G E VA+LL +S +L+V L V+K+GA Sbjct 2600 TALLSADGETLTYSQLNERANRLAHHLIDRGAGPERIVALLLPRSVELLVAELAVLKTGA 2659 Query 515 VYVPVDPSYPQDRLDFILADCDAKLVLR---TPVRELAGYRS--------------DDPT 557 ++P+DP++P DR+ + L D D LVL P G R DPT Sbjct 2660 AFLPIDPAHPADRIAYTLKDADPVLVLTDHPAPATATTGDRPVLHLHDLPLHTRPVSDPT 2719 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 DADR PL + AY+IYTSG+TG PKGV V H V + + D RLLQ AS Sbjct 2720 DADRRSPLHVSHPAYVIYTSGSTGRPKGVVVSHAGVGNLATAQIDRFALTDAGRLLQFAS 2779 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLF--LS 675 PSFD S++E+F T GA +V L L +RD IT P L Sbjct 2780 PSFDASVSEVFTTWLSGATLVTATADHLRPGTDLADTVRDLRITHATIPPVALAAMEPSD 2839 Query 676 LPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFK-VVGPQG 734 LPG L + + GE +P +V + + + N YGPTET + A+ + GPQ Sbjct 2840 LPG------LTTLVVAGEAVPAQVVEAWAPGRRMI--NAYGPTETTVCATMSTPLTGPQP 2891 Query 735 TRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF 794 VPIG P NT +++LD++L+PV GV+GE+Y+ GT +A GY R LTAERFVA PF Sbjct 2892 DS-VPIGTPITNTRVYVLDETLRPVAPGVVGELYVAGTGLARGYLNRPDLTAERFVACPF 2950 Query 795 -NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVV 853 +PG RMYR+GDL R + DG++ ++GR D+QVK+RGFRIELG+V A+ + QA VV Sbjct 2951 GSPGERMYRTGDLVRWSEDGELTYLGRTDDQVKLRGFRIELGEVETALRHLDGIRQAAVV 3010 Query 854 VSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPIT 913 + + + L+ Y D AD D +R LPE+M+PAA V LD +P+T Sbjct 3011 IREDRPGDRRLIAYTV--HDTDHTADPAALRDALRT----TLPEHMVPAAIVPLDALPLT 3064 Query 914 AHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLL 973 HGK+DR ALP P A+ RAP+T E L LF E+LG + VG DD FFDLGGHSLL Sbjct 3065 VHGKLDRTALPAPDTAATATGRAPRTVQEALLCGLFAEVLGVEDVGIDDGFFDLGGHSLL 3124 Query 974 ATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSS 1033 AT+L A VR+ GV++ VR +FE TV L + + + RP + V+ V LS + Sbjct 3125 ATRLAARVRDELGVELPVRSVFEHPTVAELVRQLGS--ASGVRPPVRAVERPTEVPLSFA 3182 Query 1034 QMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPH 1093 Q R WF FDGP+A NIP A +L G D A AAA+ DVV RHE LRTV+ + G P Sbjct 3183 QRRLWFLGHFDGPSAAYNIPLALSLTGDLDRAALAAALRDVVDRHESLRTVFPDTDGRPR 3242 Query 1094 QIIQPPAEVPVRCAAGS-DAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLV 1151 Q + + V + A L L+ + FDL TD P++A L + P++ VL L+ Sbjct 3243 QWVLETSAVSLELPVTEVTEAELPDALSAAASHAFDLTTDVPLKADLFALAPDRHVLHLL 3302 Query 1152 VHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGI 1208 VHHIA D S L DL TAY AR Q P W PL VQYADY++WQ +L DD Sbjct 3303 VHHIAADGASLAPLARDLSTAYAARRLAQAPDWEPLRVQYADYTLWQREVLGSEDDPDSK 3362 Query 1209 VGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVT 1268 V Q ++W L L E L D PRP S G V L A + ++ ++R G + Sbjct 3363 VSAQLEHWRTVLADLPEELTLPADRPRPQRSSHRGGLVPLELDAELHARITTLARRTGTS 3422 Query 1269 EFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLR 1328 FM+LQAA A +L K G G D+PIG PVAGR+++ LD L+GFF+N +VLR D GNP+ R Sbjct 3423 VFMVLQAATAALLTKMGAGTDIPIGTPVAGRTDSALDDLVGFFVNTLVLRTDTSGNPSFR 3482 Query 1329 EVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGP 1388 E+L R R LAAYAHQD+PF+++VE +NP+RS +R+PLF + + Q P + ++ P Sbjct 3483 ELLARVRDTDLAAYAHQDVPFERLVEVMNPERSAARHPLFQVNLTFHNQAPAEDGLEL-P 3541 Query 1389 DGDTTLRVLEPTFDAAQADLSVNFF------ACGDEYRGHVIYRTELYERATAQRFADWL 1442 +E T A+ DL+++ G + + +L++ +TA R A+ Sbjct 3542 GLTFGGHPVEHTV--AKYDLALSLTEQRTPGGSPAGITGALEFAVDLFDPSTAGRLAERF 3599 Query 1443 VRVVEAFADRPDQPLREVEMVSA 1465 VR++ A+A+ PD+ L +V ++ A Sbjct 3600 VRLLSAWAEEPDRVLSDVHVLDA 3622 Score = 726 bits (1873), Expect = 0.0, Method: Compositional matrix adjust. Identities = 530/1450 (37%), Positives = 754/1450 (52%), Gaps = 74/1450 (5%) Query 69 WTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIA 128 W + DLTD++ + RLE L + F+L+ +R T++R + +L HHI Sbjct 93 WQEIDLTDVAAEDEPGRLEALMAADRAQHFDLTAPPLVRFTLIRLSGRRFRFVLANHHIL 152 Query 129 WDDGSWRVFFTDLTQAYSRADLGADL---GPEHRPSAASGPDTTEADLNYWRAIMADPPE 185 D S + +L Y++ L P A + +A W +A E Sbjct 153 LDGWSMAIMLQELFVLYAQGGDATGLPRVTPYRDYLAWAAAQDRDAAAKAWGRALAGVEE 212 Query 186 PLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYT 245 P L A L + A V +A+ T ++ A++G L+ R T Sbjct 213 PTLLAPAAPAAAAEPPHYHHH--ELSEELTAAVTALARRHDLTVNTLVQASWGVLLGRLT 270 Query 246 HSDDFLVAAPVLNR---GAGTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFA 302 DD + + V R AG E +G F NT+ +R+R + +LL +D S Sbjct 271 GRDDVVFGSTVSGRPPEMAGMEHMVGLFINTLPVRVRLDAGQPVADLLRRLQDEQSELMD 330 Query 303 HQRINLDRVVRELNPDRRHGAERM-TRVSFGFREPDGGGFNPP--GIECERYDLRSNITQ 359 HQ L + L G E T +F D GF+ P G+ ++ Sbjct 331 HQHYGLSDIQSLLG-----GGELFDTITAFESYPIDTDGFSEPVDGLRVTGVH-TTDDNH 384 Query 360 LPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDE 419 P + + + + ++ A+ + R +L++ AP+ L L ++ Sbjct 385 YPFSLAI-LPGERMRLRMGYRPDLFTARQAELIGRRLQHILESFTDAPEQLLGRLDVLTG 443 Query 420 RDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGH 479 + +L + RG R P T L Q RTP A AV+ + + +Y LNE +NRL H Sbjct 444 AEREQLLQAWRGARPAVPAATFPALFEAQAARTPHAPAVLSDDESLSYAQLNERANRLAH 503 Query 480 WLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKL 539 LI++G+G E VA+LL +S D++V L V+K+G Y+PVDP YP DR+ ++L D D L Sbjct 504 HLIDRGVGPERIVALLLPRSVDIVVARLAVMKAGGAYLPVDPDYPADRIAYMLHDADPVL 563 Query 540 VLRTPVRELAGYRSD------------------------DPTDADRIRPLRPDNTAYLIY 575 VL T G+ +D DPTDA+R PL + AY+IY Sbjct 564 VLTT------GHDADRLPESTAAARLLLDRLDLTTAPATDPTDANRPAPLTVAHPAYVIY 617 Query 576 TSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGA 635 TSG+TG PKGV V H+ +A + V R+LQ +SPSFD S+ E+ +L GA Sbjct 618 TSGSTGRPKGVVVSHQGLAAFASVLAERCAVGPHSRVLQFSSPSFDASVLELCMSLPRGA 677 Query 636 RMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLF--LSLPGVSQWRTLQRVPIGGE 693 +V+P PG L D L +L D IT P+ L + LP + + +GG+ Sbjct 678 ALVVPPPGPLADEA-LGRVLADRRITHALIPPAALATVPAMDLPDFTT------LIVGGD 730 Query 694 PLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLD 753 + D++ + N YGPTE+ + A+ + + GT + IGR T++ +LD Sbjct 731 ATDAALVDRWAPGRRMV--NAYGPTESTVVATISEPL-VAGTGVPAIGRAVDGTSVLVLD 787 Query 754 DSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-PGSRMYRSGDLARRNAD 812 +L+PV GV+GE+Y+ G +A GY RA LTAERF+A P+ PG+RMYR+GDL R + D Sbjct 788 AALRPVAPGVVGELYLAGEQLARGYLGRAALTAERFIACPYGGPGARMYRTGDLVRSSED 847 Query 813 GDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAA 872 G +E++GRAD+QVK+RGFRIELG++ + + P V QAVV+V + K LV Y P Sbjct 848 GTLEYLGRADDQVKLRGFRIELGEIESVLVSHPDVAQAVVLVREDRPGDKRLVAYTVPRD 907 Query 873 GGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDT 932 P VD +R R++A LPEYM+P+++VVL E+P+TA+GK+DR ALP P+ A Sbjct 908 VQGPP----VDPRALRDRLSATLPEYMVPSSFVVLGELPLTANGKLDRKALPAPEEAVGG 963 Query 933 EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVR 992 RAP+T E L LF E+LG VG DDSFF+LGGHSL AT+LV+ VR+AF V++ +R Sbjct 964 AGRAPRTPQEEILCGLFAEILGLPAVGVDDSFFELGGHSLQATRLVSRVRSAFDVELPLR 1023 Query 993 EIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNI 1052 +FE AT LA + S RP L + LS +Q R WF RFD A NI Sbjct 1024 SLFESATPAGLAALLQR--SADGRPPLEPRPRPAEIPLSFAQRRLWFLGRFDTTGAGYNI 1081 Query 1053 PFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDA 1112 P L G D +A + A+TDV+ARHE LRTV+ E G PHQ++ PPA Sbjct 1082 PLVLQLDGELDRDALSDALTDVIARHESLRTVFAETDGRPHQVVLPPAPAAALRPVAVTD 1141 Query 1113 AWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLT 1171 L L FDL T+ P+R L + + VL L++HHIAGD WS L DL T Sbjct 1142 DDLDDRLAEAASLPFDLATETPLRVTLFALGARRHVLLLLLHHIAGDGWSLAPLARDLST 1201 Query 1172 AYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETG 1228 AY AR +G P+W PLPVQYADYS+WQ L DD + Q +W + L GL E Sbjct 1202 AYAARRSGATPAWEPLPVQYADYSLWQHELFGSEDDEDSVGARQIAHWKQVLAGLPEELA 1261 Query 1229 LRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGV 1288 L D PRPA S GD V F L + KL +SRD + FM+LQA +A +L + G G Sbjct 1262 LPTDRPRPAQASLRGDVVPFSLTPKLHRKLVQLSRDSRCSLFMVLQAGLAALLDRLGCGE 1321 Query 1289 DVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLP 1348 D+PIG VAGR++ LD L+GFF+N +VLR D G+P+ RE+L R R+ L AYAHQD+ Sbjct 1322 DIPIGTAVAGRTDEALDDLVGFFVNNLVLRCDTSGDPSFRELLARVRETDLTAYAHQDVS 1381 Query 1349 FDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADL 1408 FD++VE VNP+RSL+R+PLF +++ ++ + +R FD A +L Sbjct 1382 FDRLVEVVNPERSLARHPLFQVMLTLQNTERATLELPGLSVAPRAVRTGSARFDLA-LEL 1440 Query 1409 SVNFFACG--DEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQ 1466 A G D G V Y T+L++RAT ++F VR++EA A D+ + ++++ Sbjct 1441 GEKRGADGGHDGLDGIVEYSTDLFDRATVEKFVSRYVRLLEAVAADADRAIGRIDVLGPV 1500 Query 1467 ARRRILDRSN 1476 R +L R N Sbjct 1501 ERHELLVRRN 1510 Score = 527 bits (1357), Expect = 9e-147, Method: Compositional matrix adjust. Identities = 442/1302 (34%), Positives = 619/1302 (48%), Gaps = 161/1302 (12%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ D A NI ++ +TGD+D A L A+ V RH LRT +P D Q Sbjct 3186 LWFLGHFDGPSAAYNIPLALSLTGDLDRAALAAALRDVVDRHESLRTVFPDTDGRPRQ-- 3243 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAP----------FELSRDAPLRITV 110 W L A L L V E P F+L+ D PL+ + Sbjct 3244 --------WV------LETSAVSLELPVTEVTEAELPDALSAAASHAFDLTTDVPLKADL 3289 Query 111 VRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP---------- 160 A D HVL L+ HHIA D S DL+ AY+ L P+ P Sbjct 3290 FALAPDRHVLHLLVHHIAADGASLAPLARDLSTAYAARRLAQ--APDWEPLRVQYADYTL 3347 Query 161 ------SAASGPDT-TEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPAD 213 + PD+ A L +WR ++AD PE L LP +S R L L A+ Sbjct 3348 WQREVLGSEDDPDSKVSAQLEHWRTVLADLPEELTLPADRPRPQRSSHRGGLVPLELDAE 3407 Query 214 TAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGN 272 AR+ T+A+ TG + +MVL AA AL+ + D + PV R + +D +G+F N Sbjct 3408 LHARITTLARRTGTSVFMVLQAATAALLTKMGAGTDIPIGTPVAGRTDSALDDLVGFFVN 3467 Query 273 TVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFG 332 T+ +R SFRELL RD A+AHQ + +R+V +NP+R + +V+ Sbjct 3468 TLVLRTDTSGNPSFRELLARVRDTDLAAYAHQDVPFERLVEVMNPERSAARHPLFQVNLT 3527 Query 333 FRE--PDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDR------AGVLVEAEHLVEIL 384 F P G PG+ + + + + L + R AG+ E V++ Sbjct 3528 FHNQAPAEDGLELPGLTFGGHPVEHTVAKYDLALSLTEQRTPGGSPAGITGALEFAVDLF 3587 Query 385 EPALAKQMLRHFGVLLDNALAAPDNTLSGLALMD--ERDAARLREVSRGERFDTPVKTLV 442 +P+ A ++ F LL PD LS + ++D E +AA + DT +L Sbjct 3588 DPSTAGRLAERFVRLLSAWAEEPDRVLSDVHVLDAAEWEAALAGVGAVVGEADTHGPSLA 3647 Query 443 DLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDL 502 +L + TPDATAVV +Y DLN ++NRL L G G V + L ++ DL Sbjct 3648 ELFEARAAATPDATAVVCGDHALSYRDLNTSANRLARRLTATGAGPGRFVGLALPRTTDL 3707 Query 503 IVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRS--------D 554 + L V+K+GA YVP+DP YP +RL ++ D LVL T +L+G D Sbjct 3708 VTALLAVIKTGAAYVPMDPDYPAERLAHMVTDSAPALVLTTSGVDLSGVDCGTATVLTLD 3767 Query 555 DP--------------TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFV-- 598 DP TDADR PL + AY+IYTSG+TG PKGV +PH V F Sbjct 3768 DPHLRADLAALAGHDLTDADRGGPLTAGSAAYVIYTSGSTGRPKGVVIPHGNVVRLFSAT 3827 Query 599 --WFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVI-PRPGGLTDIGYLTALL 655 WF + DD L S +FD S+ EI+G L G R+VI P + +L ALL Sbjct 3828 DPWFG--FGPDDVWTLFH--SYAFDFSVWEIWGPLLHGGRLVIVPFEVSRSPEDFL-ALL 3882 Query 656 RDEGITAMHFVPSLLGLFLSL----PGVSQWRTLQRVPIGGEPLPGEVADKF---HATFD 708 D+ +T ++ PS + P + L+ V GGE L ++ H Sbjct 3883 ADQKVTVLNQTPSAFYQLMRTEGDRPDLGARLALRYVVFGGEALDLWRLQEWYGRHPEDA 3942 Query 709 ALLHNFYGPTETVINASRFKVVGPQGTRIVP--IGRPKINTTMHLLDDSLQPVPTGVIGE 766 L N YG TET ++ + + IGRP + +H+LD L PVP GV+GE Sbjct 3943 PRLINMYGITETTVHVTHRALDAEGAAAATGSLIGRPIPDLRVHVLDADLVPVPAGVVGE 4002 Query 767 IYIGGTHVAYGYHRRAGLTAERFVADPFNP-GSRMYRSGDLARRNADGDIEFVGRADEQV 825 +Y+ G +A GY R LTAERFVADP+ P G+RMYR+GDLARR ADGD+E++GRAD QV Sbjct 4003 MYVAGAGLARGYLGRHALTAERFVADPYGPPGTRMYRTGDLARRTADGDLEYIGRADHQV 4062 Query 826 KIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLD 885 KIRGFRIELG++ A +A P VGQ VV + + LVGYV P A D V+ + Sbjct 4063 KIRGFRIELGEIEACLAAHPQVGQVAVVAREDRPGDRKLVGYVVPEA-----EDRTVEPE 4117 Query 886 RIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRL 945 +R + LPEYM+P+A+V L +P+TA+GK+DR ALP P A+ RA +T E L Sbjct 4118 GLRKHLRTQLPEYMVPSAFVTLPRLPLTANGKLDRKALPAPDFAAAVGGRAARTEREELL 4177 Query 946 AQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAG 1005 LF E+LG VG DD FFDLGG S+++ +LVA R A G+ + R++FE TV ALA Sbjct 4178 CGLFAEVLGLPSVGVDDGFFDLGGDSIVSIQLVARARRA-GLLLTPRDVFEHKTVEALAA 4236 Query 1006 HIDTLDSDSARPRLTRVDHDGP----VRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGP 1061 T+D R +GP + ++ + W R GP V+ + L P Sbjct 4237 VATTVD---------RTADEGPDAGIGTVGATPIVRWLEER-GGP--VDRFNQSMLLQVP 4284 Query 1062 CDTNA--FAAAITDVVARHEILRT-VYREIGG----VP-----------HQIIQPPAEVP 1103 +A AA+ ++ H++LR + R G VP H++ P V Sbjct 4285 AGASAAHLTAALQTLLDHHDMLRARLTRGADGWSLEVPDRGTVDAAALLHRVALPSGPVR 4344 Query 1104 VRCAAG-----SDAAWLRAELNNERGYV-----FDLETDWPIRAALLSTPEQTVLSLVVH 1153 A + AAW R L+ E G + FD D R L L+ H Sbjct 4345 AETLAAALEEHATAAWDR--LSPENGVMVQALWFDAGPDHSGR-----------LLLIAH 4391 Query 1154 HIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYS 1195 H+ D S ++ DL AY+A + G +P P+P + ++ Sbjct 4392 HLVVDGVSWRIIAPDLAAAYQALADGGKPVLEPVPTSFRTWA 4433 Score = 68.2 bits (165), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 36/77 (47%), Positives = 46/77 (60%), Gaps = 1/77 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RVY+LD+ L+PV GVVG++Y G L RP TA RFVA PF + PG R+YR G+ Sbjct 2904 RVYVLDETLRPVAPGVVGELYVAGTGLARGYLNRPDLTAERFVACPFGS-PGERMYRTGD 2962 Query 1543 RGVWKADGQLELLAEIE 1559 W DG+L L + Sbjct 2963 LVRWSEDGELTYLGRTD 2979 Score = 64.7 bits (156), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 99/392 (26%), Positives = 157/392 (41%), Gaps = 33/392 (8%) Query 1092 PHQIIQPPAEVPVR------CAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPE 1144 P QII E+P + AA + L A + +R FDL +R L+ + Sbjct 81 PVQIIPREVELPWQEIDLTDVAAEDEPGRLEALMAADRAQHFDLTAPPLVRFTLIRLSGR 140 Query 1145 QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDD 1204 + L HHI D WS ++ +L Y + G + P Y DY L Sbjct 141 RFRFVLANHHILLDGWSMAIMLQELFVLY---AQGGDATGLPRVTPYRDY------LAWA 191 Query 1205 GAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRD 1264 A W R L G+ T L PA + L + + A++R Sbjct 192 AAQDRDAAAKAWGRALAGVEEPTLLA--PAAPAAAAEPPHYHHHELSEELTAAVTALARR 249 Query 1265 LGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGR--SEANLDQLIGFFINIVVLRNDLR 1322 +T L+QA+ V+L + G DV G+ V+GR A ++ ++G FIN + +R L Sbjct 250 HDLTVNTLVQASWGVLLGRLTGRDDVVFGSTVSGRPPEMAGMEHMVGLFINTLPVRVRLD 309 Query 1323 GNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDH 1382 + ++L+R + HQ + Q L LFD + E P D Sbjct 310 AGQPVADLLRRLQDEQSELMDHQHYGLSDI------QSLLGGGELFDTITAF-ESYPIDT 362 Query 1383 VIDTGP-DGDTTLRVLE-PTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFAD 1440 + P DG LRV T D S+ G+ R + YR +L+ A+ Sbjct 363 DGFSEPVDG---LRVTGVHTTDDNHYPFSLAILP-GERMRLRMGYRPDLFTARQAELIGR 418 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQARRRIL 1472 L ++E+F D P+Q L +++++ R ++L Sbjct 419 RLQHILESFTDAPEQLLGRLDVLTGAEREQLL 450 Score = 63.5 bits (153), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/73 (48%), Positives = 45/73 (62%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RV++LD L PVP GVVG++Y G L R + TA RFVADP+ PG+R+YR G+ Sbjct 3984 RVHVLDADLVPVPAGVVGEMYVAGAGLARGYLGRHALTAERFVADPY-GPPGTRMYRTGD 4042 Query 1543 RGVWKADGQLELL 1555 ADG LE + Sbjct 4043 LARRTADGDLEYI 4055 Score = 63.2 bits (152), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 40/93 (44%), Positives = 53/93 (57%), Gaps = 3/93 (3%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPV 1635 TE E L + A+VL + VG D FF+LGGDSI++ Q+ ARAR G+ LT R VFEH Sbjct 4171 TEREELLCGLFAEVLGLPSVGVDDGFFDLGGDSIVSIQLVARARRAGLLLTPRDVFEHKT 4230 Query 1636 LCELAAAVDAKPHVEAEPDDKHHAPMSTSGLSP 1668 + LAA V+ D+ A + T G +P Sbjct 4231 VEALAAVATT---VDRTADEGPDAGIGTVGATP 4260 Score = 60.5 bits (145), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 34/65 (53%), Positives = 43/65 (67%), Gaps = 1/65 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T E L + A+VL V +VG D FF+LGG S+LAT++AAR RD G+ L R VFEHP Sbjct 3090 TVQEALLCGLFAEVLGVEDVGIDDGFFDLGGHSLLATRLAARVRDELGVELPVRSVFEHP 3149 Query 1635 VLCEL 1639 + EL Sbjct 3150 TVAEL 3154 Score = 55.5 bits (132), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/72 (45%), Positives = 42/72 (59%), Gaps = 1/72 (1%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 V +LD AL+PV GVVG++Y G L R + TA RF+A P+ PG+R+YR G+ Sbjct 783 VLVLDAALRPVAPGVVGELYLAGEQLARGYLGRAALTAERFIACPYGG-PGARMYRTGDL 841 Query 1544 GVWKADGQLELL 1555 DG LE L Sbjct 842 VRSSEDGTLEYL 853 Score = 40.0 bits (92), Expect = 4.1, Method: Compositional matrix adjust. Identities = 25/67 (38%), Positives = 35/67 (53%), Gaps = 1/67 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T E L + A++L + VG D FF LGG S+ AT++ +R R + L R +FE Sbjct 970 TPQEEILCGLFAEILGLPAVGVDDSFFELGGHSLQATRLVSRVRSAFDVELPLRSLFESA 1029 Query 1635 VLCELAA 1641 LAA Sbjct 1030 TPAGLAA 1036 >gi|186682529|ref|YP_001865725.1| amino acid adenylation domain-containing protein [Nostoc punctiforme PCC 73102] gi|186464981|gb|ACC80782.1| amino acid adenylation domain protein [Nostoc punctiforme PCC 73102] Length=4389 Score = 867 bits (2239), Expect = 0.0, Method: Compositional matrix adjust. Identities = 515/1535 (34%), Positives = 813/1535 (53%), Gaps = 79/1535 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ +P+ A NI ++ R+ G+++ L ++ + RH LRT + + DG +P+ Sbjct 1120 LWFLDQFEPNSAFYNIPMALRLVGNLNQPALEQSLLEIIHRHEALRTNF-IRVDG--KPS 1176 Query 61 VHADLRPGWTQ--YDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 + WT DL LS Q + + LA+++ PF+L+ A +R T++ + EH Sbjct 1177 QIIQTQTNWTVSVIDLKYLSTTDQEITSQELARQQAIEPFDLANGALIRTTLLVLSQTEH 1236 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGP 166 +LL+ HH+ D S VF +L Y G AD R Sbjct 1237 ILLVCMHHVVSDGWSMGVFVQELAALYDAYAQGQPSPLTPLPIQYADFAIWQREWLQG-- 1294 Query 167 DTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTG 226 + + L YW+ +A+ P L LP ++ A L A+ R+ +++ G Sbjct 1295 NVLQNQLTYWQQQLANAPALLSLPTDRPRPAVQTFAGAYQKFALSAELTGRLIQLSQKQG 1354 Query 227 CTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAMS 285 T +M LLAAF L++RYT ++D LV +P+ NR + E IG+F NT+ MR S Sbjct 1355 VTLFMTLLAAFDTLLYRYTGTEDILVGSPIANRDRSEIEGLIGFFVNTLVMRTDLAGNPS 1414 Query 286 FRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPG 345 F ELLT R+IA A++HQ + + +V L P+R + +V F + Sbjct 1415 FSELLTRVREIAMEAYSHQHLPFEMLVEALQPERDLSHTPLFQVMFTLQNAPISTVELNQ 1474 Query 346 IECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALA 405 + + + L +E GV+ E+ ++ + + ++M HF LL++ +A Sbjct 1475 LSVSSTLIEGTTAKFDLTLSMENTATGVVGVWEYSTDLFDASTIERMTGHFVTLLESIIA 1534 Query 406 APDNTLSGLALMDERDAARLREVSRGERFDTPV-KTLVDLVNEQTTRTPDATAVVYEGQH 464 P ++S L L+ E + +L + D P+ K L L EQ RTPDA AVV+E Q Sbjct 1535 NPQQSISQLPLLTEIEQQQLLVEWNNTQADYPLDKCLHQLFEEQVARTPDAVAVVFENQQ 1594 Query 465 FTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYP 524 TY LN +N+L H+L G+G++ V + L++S ++V LG++K+G YVP+DP YP Sbjct 1595 LTYQQLNCRANKLAHYLQSLGVGADVLVGICLERSLLMVVGLLGILKAGGAYVPLDPDYP 1654 Query 525 QDRLDFILADCDAKLVL--RTPVRELAGYRSDD------------PTDADRIRPLRPDNT 570 QDRL F+L D +++L + ++L ++ D + + I ++ N Sbjct 1655 QDRLSFMLEDAQVRVLLTQQQLKKKLPQHQGQDIYLDTDWQFISQSSQENPITTVQGSNL 1714 Query 571 AYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGT 630 AY+IYTSG+TG PKG H + +W + Y + D D +LQ SFDVS+ E F Sbjct 1715 AYVIYTSGSTGKPKGAMNTHLGICNRLLWMQQAYQLTDVDCILQKTPFSFDVSVWEFFWP 1774 Query 631 LACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPI 690 L GAR+V+ + GG D YL L+ ++ +T +HFVPS+L +FL P + R+L+R Sbjct 1775 LITGARLVVAKAGGHKDSAYLVNLILEQQVTHVHFVPSMLQVFLEEPSLENCRSLKRFIC 1834 Query 691 GGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMH 750 GE LP E+ ++F A + LHN YGPTE I+ + ++ RIVPIG+P NT ++ Sbjct 1835 SGEALPVELQERFFARLECELHNLYGPTEAAIDVTYWQCFPNGNLRIVPIGQPIANTQIY 1894 Query 751 LLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRN 810 +LD+ LQPVP GV GE++IGG +A GY R LT E+F+++PF S++Y++GDLAR Sbjct 1895 ILDEHLQPVPVGVAGELHIGGAGLARGYLNRPELTKEKFISNPFE-NSKLYKTGDLARYL 1953 Query 811 ADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTP 870 DG IE++ R D QVKIRGFRIELG++ + V + V+ + K LV Y+ P Sbjct 1954 PDGTIEYIERIDNQVKIRGFRIELGEIEVLLNQYEEVQASCVIAREGTTGDKCLVAYIVP 2013 Query 871 AAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIAS 930 + +R + A LP+YM+P+A+V+L+ +P+T++GK+DR ALP P + S Sbjct 2014 HQHSKPTT------NELRQFLKAKLPDYMVPSAFVILESMPLTSNGKVDRRALPAPDLYS 2067 Query 931 DT--EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVD 988 + ++ AP+T E LAQ + ++L +VG D+FF+LGGHSLLAT+LV+ +RN F V+ Sbjct 2068 EIKDKYVAPRTPIEEILAQTWSQVLQLPQVGIHDNFFELGGHSLLATQLVSRIRNIFKVE 2127 Query 989 VGVREIFEFATVTALAGHIDTLDSD--------------------SARPRLTRVDHDGPV 1028 + +RE+F AT+ LA I+ L SA P L R + + + Sbjct 2128 LPLRELFAAATLAELAREIEQLQQQVLRLTSAPLGTSRSVQDLQLSAPPILPRAE-NALL 2186 Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 LS +Q R WF +F+ + N+ A L G + A + +++ RHE LRT + + Sbjct 2187 ALSYAQQRLWFLDQFEPNSPFYNMSIALRLAGTVEVAALEQSFQEIIHRHEALRTNFITV 2246 Query 1089 GGVPHQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYV------FDLETDWPIRAALLST 1142 G QIIQ V + + E +++ F+L T +RA L+ Sbjct 2247 DGQATQIIQTETNWTVSVVDLKHLSTTKQETASQQLVQQQAIQPFELATQALVRATLVVL 2306 Query 1143 PE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSAL 1201 E + +L + +HHI D WS G+ +L T Y A S G+ + APLP+QYAD+++WQ Sbjct 2307 SETEHILLMCIHHIVSDGWSIGLFLQELATLYNAYSQGKSSTLAPLPIQYADFALWQREW 2366 Query 1202 LDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAV 1261 L ++ Q YW ++L L D PRPA+ + G EF L + KLA + Sbjct 2367 LQ--GEVLQSQLSYWQQKLASAPTLLSLPTDRPRPAVQTYQGTHQEFALSEELTGKLAKL 2424 Query 1262 SRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDL 1321 S++ GVT FM L AA +L++ G D+ +G+P+A R + ++ LIGFF+N +V+R DL Sbjct 2425 SQEQGVTLFMTLLAAFDTLLYRYTGTEDILVGSPIANRDRSEIEGLIGFFVNTLVMRTDL 2484 Query 1322 RGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQD 1381 GNP+ E+L R R+MA+ AY+HQ LPF+ +VEA+ P+R LS PLF V+ V + P Sbjct 2485 SGNPSFSELLGRVREMAMEAYSHQHLPFEMLVEALQPERDLSHTPLFQ-VMFVLQNAPTS 2543 Query 1382 HVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADW 1441 + TG T+ L ++ DL++ G Y T+L++ +T +R Sbjct 2544 GLELTG----LTVSSLPIKGTTSRFDLTLIMQNTPTGLVGVWEYNTDLFDASTIERMTGH 2599 Query 1442 LVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 V ++E P++ + ++ +++ ++++L N Sbjct 2600 FVTLLEGIIANPEERISQLPLLTQPEQQKLLVEWN 2634 Score = 767 bits (1980), Expect = 0.0, Method: Compositional matrix adjust. Identities = 492/1570 (32%), Positives = 789/1570 (51%), Gaps = 124/1570 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ +P+ N+ ++ R+ G +++A L + + RH LRT + + DG A Sbjct 2195 LWFLDQFEPNSPFYNMSIALRLAGTVEVAALEQSFQEIIHRHEALRTNF-ITVDGQATQI 2253 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + + + DL LS Q + L Q++ PFEL+ A +R T+V + EH+L Sbjct 2254 IQTETNWTVSVVDLKHLSTTKQETASQQLVQQQAIQPFELATQALVRATLVVLSETEHIL 2313 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGPDT 168 L+ HHI D S +F +L Y+ G AD R + Sbjct 2314 LMCIHHIVSDGWSIGLFLQELATLYNAYSQGKSSTLAPLPIQYADFALWQREWLQG--EV 2371 Query 169 TEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCT 228 ++ L+YW+ +A P L LP +++ L + ++A +++ G T Sbjct 2372 LQSQLSYWQQKLASAPTLLSLPTDRPRPAVQTYQGTHQEFALSEELTGKLAKLSQEQGVT 2431 Query 229 PYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAMSFR 287 +M LLAAF L++RYT ++D LV +P+ NR + E IG+F NT+ MR SF Sbjct 2432 LFMTLLAAFDTLLYRYTGTEDILVGSPIANRDRSEIEGLIGFFVNTLVMRTDLSGNPSFS 2491 Query 288 ELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIE 347 ELL R++A A++HQ + + +V L P+R + +V F + G G+ Sbjct 2492 ELLGRVREMAMEAYSHQHLPFEMLVEALQPERDLSHTPLFQVMFVLQNAPTSGLELTGLT 2551 Query 348 CERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAP 407 ++ ++ L +++ G++ E+ ++ + + ++M HF LL+ +A P Sbjct 2552 VSSLPIKGTTSRFDLTLIMQNTPTGLVGVWEYNTDLFDASTIERMTGHFVTLLEGIIANP 2611 Query 408 DNTLSGLALMDERDAARLREVSRGERFDTPVKTLV-DLVNEQTTRTPDATAVVYEGQHFT 466 + +S L L+ + + +L + D P + L EQ TP+A AVVYE Q T Sbjct 2612 EERISQLPLLTQPEQQKLLVEWNDTQVDYPEDLCIHQLFEEQVDSTPNAIAVVYENQQLT 2671 Query 467 YHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQD 526 Y++LN +N+L H+L G+GS+ V + +++S ++++ LG++K+GA YVP+DP YP D Sbjct 2672 YYELNYRANQLAHYLRSLGVGSDALVGLCVERSLEMVIGLLGILKAGAAYVPLDPEYPSD 2731 Query 527 RLDFILADCDAKLVL-------RTPVRE--LAGYRSD-----DPTDADRIRPLRPDNTAY 572 RL FIL D ++L R P + L +D + + I ++ +N AY Sbjct 2732 RLSFILEDAQVSVLLTQQSILDRLPQHQAHLVCLDTDAQLISQCSQDNLISDVQANNLAY 2791 Query 573 LIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLA 632 +IYTSG+TG PKG+A+ ++ +W + + + LQ AS SFDVS EIF T Sbjct 2792 IIYTSGSTGQPKGIAMNQLALSNLILWHRENLKIPRGAKTLQFASISFDVSFQEIFTTWC 2851 Query 633 CGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGG 692 G + + D L L+ + I M F+P F++L + L V IGG Sbjct 2852 SGGTLFLIGEELRRDTSALLGFLQQKAIERM-FLP-----FVAL------QQLAEVAIGG 2899 Query 693 EPL---------PGE-------VADKFHATFDALLHNFYGPTETVINASRFKVVGPQGT- 735 E + GE ++ D LHN YGP+E+ + A+ F + T Sbjct 2900 ELVNSHLREIITAGEQLQITPAISQWLSKLTDCTLHNHYGPSESHL-ATSFTLTNSVETW 2958 Query 736 -RIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF 794 + P+GRP N +++LD LQPVP GV GE+YI G ++ GY R LT E+F+ +PF Sbjct 2959 PLLPPVGRPIANAQIYILDKYLQPVPVGVPGELYIAGVLLSQGYFNRPELTLEKFIPNPF 3018 Query 795 N---------------PGSR--------MYRSGDLARRNADGDIEFVGRADEQVKIRGFR 831 GSR +Y++GDLAR +DG+IE++GR D QVKIRGFR Sbjct 3019 KRSRGAALRLRSVTDEQGSRGETFNSDRLYKTGDLARYLSDGNIEYLGRIDNQVKIRGFR 3078 Query 832 IELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGP--ADVGVDLDRIRA 889 IELG++ A ++ + D+P K LV Y+ P + + + +R+ Sbjct 3079 IELGEIEAVLSQLDVQASCAIAREDIPG-NKHLVAYIVPQEEQTCTERSRSTLTVSFVRS 3137 Query 890 RVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDT--EFRAPQTATERRLAQ 947 + LPEYM+P+A V+LD +P+T +GK+DR ALP P + S ++ AP+ E L+ Sbjct 3138 FLKEKLPEYMVPSAIVILDALPLTPNGKLDRRALPAPDLHSQLLDKYVAPRNPIEEILSL 3197 Query 948 LFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI 1007 ++ ++L ++VG D+FF+LGGHSLLAT+L++ VR + V++ +R +F TV L +I Sbjct 3198 IWAQVLKVEQVGIYDNFFELGGHSLLATQLISRVRTSLKVELPLRSLFAAPTVAELCQNI 3257 Query 1008 DTLDSDS----ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCD 1063 L A P L R + + + LS +Q R WF + + +A N P A L G + Sbjct 3258 QRLQQQDLELIASPILQRAE-NAELPLSFAQTRLWFLDKLNPNSAFYNFPIALRLVGTLN 3316 Query 1064 TNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPV------------------R 1105 A ++ ++V RHE LRT + + G P QIIQ + Sbjct 3317 RTALEQSLQEIVHRHEALRTNFVIVDGKPSQIIQAQINCTLSVVEFKHLSTLVLSEDVGE 3376 Query 1106 CAAGSDAAWLRAELNNERGYVFDLETDWPIRAAL--LSTPEQTVLSLVVHHIAGDHWSAG 1163 +A ++ L FDL + +RA L LS E T+L + +HHI D WS G Sbjct 3377 ASASAEVTEQETALQQLAQQPFDLANEALVRATLIVLSQTEHTLL-VCMHHIVSDGWSMG 3435 Query 1164 VLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGL 1223 V +L Y A S G PLP+QYAD+++WQ L ++ Q YW +QL Sbjct 3436 VFVQELAALYNAYSQGDLSPLTPLPIQYADFAIWQRNWLQ--GDVLQSQLSYWQKQLANA 3493 Query 1224 AGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHK 1283 L D PRP++ + AG +F L + DKL +S+ GVT FM L AA +L++ Sbjct 3494 PALLSLPTDRPRPSMQTFAGAYQQFALSKELTDKLTQLSQQQGVTLFMTLLAAFDTLLYR 3553 Query 1284 AGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYA 1343 G D+ +G+P+A R + ++ LIGFF+N +V+R +L GNP+ E+L R R+MA+ AY+ Sbjct 3554 YTGTEDILVGSPIANRDRSEIEGLIGFFLNTLVMRTNLAGNPSFSELLGRVREMAMDAYS 3613 Query 1344 HQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVID-TGPDGDTTLRVLEPTFD 1402 HQ+LPF+ +VEA+ P+R LS PLF V+ V + P ++ TG T+ L Sbjct 3614 HQNLPFEMLVEALQPERDLSHTPLFQ-VMFVLQNAPISQQLELTG----LTVSPLVVKST 3668 Query 1403 AAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEM 1462 + DL++ G Y T+L++ +T +R + ++E P++ + ++ + Sbjct 3669 NTKFDLTLAMENTATGLVGMWEYNTDLFDASTIERMTGHFLTLLEGIIANPEERISQLPL 3728 Query 1463 VSAQARRRIL 1472 ++ + ++L Sbjct 3729 LTEVEQHQLL 3738 Score = 711 bits (1836), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/1610 (32%), Positives = 785/1610 (49%), Gaps = 175/1610 (10%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ P NI + +I +++ + + RH ILRTTY + +P Sbjct 18 MWFIYQIAPESVAYNIFTTVKINSYLNIVAVNRVWEKIIERHPILRTTY---TNFEGKPV 74 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFC---APFELSRDAPLRITVVRTAADE 117 + QY A + L ++ F +PFEL +DA LRI + + E Sbjct 75 QQVN-----QQYKCNVEVINASNWSEDYLKEKIFAITDSPFELEKDAVLRINLFTRSTKE 129 Query 118 HVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLNY-- 175 H+LLL HHIA D S+ + ++ Y++ ++ + + PD+ + +Y Sbjct 130 HILLLTMHHIAGDMWSFDLLLSEFQTLYAK-----EVEQVSQEQIQTAPDSFTENKSYLD 184 Query 176 ---WRAIMADPPEPLELPGPAGTCVPTSWRAARA-------------------------T 207 W++ M L G G + W+ A + Sbjct 185 FVRWQSEM--------LSGSRGEKLWQYWQKQLAGELPILNLFADKPRPPVQTYQGTGYS 236 Query 208 LRLPADTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNR-GAGTEDA 266 L+L ++ +A +G + Y VLLAAF L++RYT+ D L+ +P+ R G ++ Sbjct 237 LKLDEQLIQKLKCLALASGTSLYQVLLAAFYVLLYRYTNQTDILIGSPMRGRWGGDFKEI 296 Query 267 IGYFGNTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERM 326 +GYF N + +R Q +F E L A HQ + +L P+R + Sbjct 297 VGYFVNLMVLRTSVQENATFTEFLAHISKTVKEAQKHQDYPFSLLAEQLEPERDPSRSPL 356 Query 327 TRVSFGFREPDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEI--- 383 +VSF ++ + E L L +FD +++EA+ ++++ Sbjct 357 CQVSFTWQRQRWCEQTENSLHSEEQVLEMKPYLLGHQRGADFDLNLMVMEAQGVLQLCWQ 416 Query 384 -----LEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPV 438 E + ++ HF LL+ +A P + L L+ E + +L E DT V Sbjct 417 YNTDLFEASTITRIAGHFVTLLEGIVANPQKQIWQLPLLTEIEQQQLL----VEWNDTGV 472 Query 439 KTLVD-----LVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVA 493 L D L EQ RTPDA AVV+E Q TY LN +N+L H+L G+G V Sbjct 473 DYLQDKCIHQLFEEQVERTPDAIAVVFENQQLTYQQLNCRANQLAHYLQSLGVGENVLVG 532 Query 494 VLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP--VREL--- 548 + +++S +++V LG++K+G YVP+DP YP +RL F+L D K++L V L Sbjct 533 LCVERSLEMVVGLLGILKAGGAYVPLDPEYPAERLSFMLKDTQVKVLLTQEKLVESLPQH 592 Query 549 --------AGYRSDDPTDADRI-RPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVW 599 ++S + D + + +N +Y+IYTSG+TG PKGVAV H+ V + Sbjct 593 QACVVCLDTDWQSISQVNQDNLDSTVSAENLSYVIYTSGSTGTPKGVAVTHQAVNRLML- 651 Query 600 FKGEYDVDDTDRLL-QVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDE 658 Y D + Q A+ +FD + EI+G L GA++VI L + + Sbjct 652 -NTNYIQLTADECVAQAANIAFDAATFEIWGALLHGAKLVIITKFVLLIPEEFAVNIHEH 710 Query 659 GITAMHFVPSLLGLFLSLPGVSQ-WRTLQRVPIGGEPL-PG---EVADKFHATFDALLHN 713 I+ + +L S+ V Q + +L+ + GGE + P EV DK LLH Sbjct 711 QISVLFLTTALFNQLASV--VPQAFSSLRYLLFGGEAVDPKWVLEVLDK--GAPQHLLH- 765 Query 714 FYGPTETVINASRFKVVGPQGT-RIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGT 772 YGPTE +S + V T +PIGR NT +++LD +LQPVP GV GEIY+GG Sbjct 766 VYGPTENTTFSSWYLVEDLATTATTIPIGRAIANTQIYILDQNLQPVPVGVPGEIYLGGA 825 Query 773 HVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRI 832 +A GY R LT ++F+ +PF+ S++Y++GDLA ADG+IE++GR D QVKIRGFRI Sbjct 826 GLAQGYFNRPELTKDKFIPNPFD-NSKLYKTGDLAHYLADGNIEYLGRIDNQVKIRGFRI 884 Query 833 ELGDVAAAIAVDPTVGQAVVVV-SDLP------RL---------GKSLVGYVTPAAGGDG 876 EL ++ ++ V + V+V D P RL K LV YV Sbjct 885 ELSEIEVVLSQHSDVQVSCVIVREDTPGDTCTERLVPSGAEVSRSKRLVAYVV------A 938 Query 877 PADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTE--F 934 D + +R + A LP+YM+P A V+L+ +P+T +GK+DR ALP P + S+ + F Sbjct 939 YQDCKPTISELRQFLTAKLPDYMVPNAIVILESLPLTPNGKVDRRALPIPDLHSEQQEKF 998 Query 935 RAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREI 994 AP+ E LA L+ ++L + +G D+FF+LGGHSLLAT+LV+ +RN F +++ +RE+ Sbjct 999 VAPRNPMEEMLALLWTQVLKVELLGIHDNFFELGGHSLLATQLVSRIRNVFKLELPLREL 1058 Query 995 FEFATVTALAGHIDTLDSDSAR--------------------PRLTRVDHDGPVRLSSSQ 1034 F ATV LA I L + R P L ++ D + LS +Q Sbjct 1059 FARATVAELAKSIRQLQQQALRLTSAPLGTSRSVQDLELSEPPILPKM-RDAELPLSYAQ 1117 Query 1035 MRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQ 1094 R WF +F+ +A NIP A L G + A ++ +++ RHE LRT + + G P Q Sbjct 1118 QRLWFLDQFEPNSAFYNIPMALRLVGNLNQPALEQSLLEIIHRHEALRTNFIRVDGKPSQ 1177 Query 1095 IIQPPAE-----VPVRCAAGSDAAWLRAELNNERGYV-FDLETDWPIRAALLSTPE-QTV 1147 IIQ + ++ + +D EL ++ FDL IR LL + + + Sbjct 1178 IIQTQTNWTVSVIDLKYLSTTDQEITSQELARQQAIEPFDLANGALIRTTLLVLSQTEHI 1237 Query 1148 LSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAG 1207 L + +HH+ D WS GV +L Y A + GQ PLP+QYAD+++WQ L Sbjct 1238 LLVCMHHVVSDGWSMGVFVQELAALYDAYAQGQPSPLTPLPIQYADFAIWQREWLQ--GN 1295 Query 1208 IVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGV 1267 ++ Q YW +QL L D PRPA+ + AG +F L A + +L +S+ GV Sbjct 1296 VLQNQLTYWQQQLANAPALLSLPTDRPRPAVQTFAGAYQKFALSAELTGRLIQLSQKQGV 1355 Query 1268 TEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTL 1327 T FM L AA +L++ G D+ +G+P+A R + ++ LIGFF+N +V+R DL GNP+ Sbjct 1356 TLFMTLLAAFDTLLYRYTGTEDILVGSPIANRDRSEIEGLIGFFVNTLVMRTDLAGNPSF 1415 Query 1328 REVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE------QMPQD 1381 E+L R R++A+ AY+HQ LPF+ +VEA+ P+R LS PLF ++ ++ ++ Q Sbjct 1416 SELLTRVREIAMEAYSHQHLPFEMLVEALQPERDLSHTPLFQVMFTLQNAPISTVELNQL 1475 Query 1382 HVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADW 1441 V T +G T A+ DL+++ G Y T+L++ +T +R Sbjct 1476 SVSSTLIEGTT-----------AKFDLTLSMENTATGVVGVWEYSTDLFDASTIERMTGH 1524 Query 1442 LVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDAL 1491 V ++E+ P Q + ++ +++ ++++L N T Y LD L Sbjct 1525 FVTLLESIIANPQQSISQLPLLTEIEQQQLLVEWN---NTQADYPLDKCL 1571 Score = 514 bits (1323), Expect = 7e-143, Method: Compositional matrix adjust. Identities = 336/1093 (31%), Positives = 550/1093 (51%), Gaps = 96/1093 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ +P+ A N ++ R+ G ++ L ++ + RH LRT + + D +Q Sbjct 3290 LWFLDKLNPNSAFYNFPIALRLVGTLNRTALEQSLQEIVHRHEALRTNFVIVDGKPSQ-I 3348 Query 61 VHADLRPGWTQYDLTDLSQRA----------------QRLRLEVLAQREFCAPFELSRDA 104 + A + + + LS Q L+ LAQ+ PF+L+ +A Sbjct 3349 IQAQINCTLSVVEFKHLSTLVLSEDVGEASASAEVTEQETALQQLAQQ----PFDLANEA 3404 Query 105 PLRITVVRTAADEHVLLLVAHHIAWDDGSWRVFFTDLT---QAYSRADLG---------A 152 +R T++ + EH LL+ HHI D S VF +L AYS+ DL A Sbjct 3405 LVRATLIVLSQTEHTLLVCMHHIVSDGWSMGVFVQELAALYNAYSQGDLSPLTPLPIQYA 3464 Query 153 DLGPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPA 212 D R D ++ L+YW+ +A+ P L LP ++ A L Sbjct 3465 DFAIWQRNWLQG--DVLQSQLSYWQKQLANAPALLSLPTDRPRPSMQTFAGAYQQFALSK 3522 Query 213 DTAARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFG 271 + ++ +++ G T +M LLAAF L++RYT ++D LV +P+ NR + E IG+F Sbjct 3523 ELTDKLTQLSQQQGVTLFMTLLAAFDTLLYRYTGTEDILVGSPIANRDRSEIEGLIGFFL 3582 Query 272 NTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSF 331 NT+ MR SF ELL R++A A++HQ + + +V L P+R + +V F Sbjct 3583 NTLVMRTNLAGNPSFSELLGRVREMAMDAYSHQNLPFEMLVEALQPERDLSHTPLFQVMF 3642 Query 332 GFRE-PDGGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAK 390 + P G+ ++S T+ L +E G++ E+ ++ + + + Sbjct 3643 VLQNAPISQQLELTGLTVSPLVVKSTNTKFDLTLAMENTATGLVGMWEYNTDLFDASTIE 3702 Query 391 QMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLV-DLVNEQT 449 +M HF LL+ +A P+ +S L L+ E + +L + D P+ + L EQ Sbjct 3703 RMTGHFLTLLEGIIANPEERISQLPLLTEVEQHQLLVEWTDTQVDYPLDLCIHQLFEEQV 3762 Query 450 TRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGV 509 RTPDA AVV+E Q TYH LN +N+L H+L G+ ++ V + +++S +++V LG+ Sbjct 3763 QRTPDAVAVVFEDQQLTYHQLNSRANQLAHYLKSLGVRADVLVGICVERSIEMVVGLLGI 3822 Query 510 VKSGAVYVPVDPSYPQDRLDFILADC------------------DAKLVLRTPVRELAGY 551 +K+G Y+P+DP YP +RL F+L D AKLV +L Sbjct 3823 LKAGGAYLPLDPEYPTERLHFMLEDAQVSVLLTQQKLLDRLSQHQAKLVCLDTDWQLISQ 3882 Query 552 RSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDR 611 S D + I + N AY+IYTSG+TG PKGV + H+ + W + + + D+ Sbjct 3883 SSQD----NLITETQATNLAYVIYTSGSTGQPKGVLIAHQGLLNLVFWHQHTFKITTLDK 3938 Query 612 LLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLG 671 Q+A +FD ++ E++ L GA + + + L+ + L L + IT + F+P+ L Sbjct 3939 ATQLAGTAFDAAVWELWPYLTAGASIYLVKSEFLSSLVKLRDWLISKQIT-ISFLPTPLA 3997 Query 672 L-FLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDAL----LHNFYGPTETVINASR 726 LSL ++ L+ + GG DK H L L N YGPTE + + Sbjct 3998 QELLSLEWPTESLALRTILTGG--------DKLHQYPSDLVPFQLVNNYGPTENTVVTTS 4049 Query 727 FKVVGPQGTRIVP-IGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLT 785 VV + +I P IGR NT +++LD +LQPVP G+ GE++I G +A GY R LT Sbjct 4050 GLVVAKEQDQISPSIGRAIANTQIYILDSNLQPVPIGIPGELHIAGVGLAKGYLNRPELT 4109 Query 786 AERFVADPFNPG-SRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVD 844 E+F+ +PF+ G S++Y++GDL R DG+IE++GR D QVKIRGFRIEL ++ A + Sbjct 4110 TEKFILNPFDEGVSKLYKTGDLVRYLPDGNIEYLGRIDNQVKIRGFRIELAEIEALLGQH 4169 Query 845 PTVGQAVVV---------VSDLPRLGKSLVGYVTP--AAGGDGPADVGVDLDRIRARVAA 893 V V+ ++ R K LV YV P A + D +R + Sbjct 4170 DDVQICCVIAREETSGNTCTERSR-SKRLVAYVVPHLHATCTERSRSTPTTDELRQFLDD 4228 Query 894 ALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASD-TEFRAPQTATERRLAQLFGEL 952 LP YM+P+ +V+L+ +P+T +GK+DR ALP P + + + + P T E+ +A ++ Sbjct 4229 KLPGYMVPSVFVMLESLPLTPNGKVDRRALPAPDLQQELSNYVMPNTEVEKIIAGIWQNT 4288 Query 953 LGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI----- 1007 L ++VG ++FF+LGGHSLL ++ ++ FG++V + ++F + T+ L+ ++ Sbjct 4289 LEVEKVGIYNNFFELGGHSLLLIRINQQLQEKFGLEVSIVDMFNYPTIHRLSQYLSTKLN 4348 Query 1008 --DTLDSDSARPR 1018 DTL +++RP+ Sbjct 4349 KEDTLKQNNSRPQ 4361 Score = 167 bits (423), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 122/461 (27%), Positives = 210/461 (46%), Gaps = 17/461 (3%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIG 1089 LSS Q WF Y+ + NI ++ + A ++ RH ILRT Y Sbjct 11 LSSGQEAMWFIYQIAPESVAYNIFTTVKINSYLNIVAVNRVWEKIIERHPILRTTYTNFE 70 Query 1090 GVPHQII--QPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQT 1146 G P Q + Q V V A+ +L+ ++ F+LE D +R L + + ++ Sbjct 71 GKPVQQVNQQYKCNVEVINASNWSEDYLKEKIFAITDSPFELEKDAVLRINLFTRSTKEH 130 Query 1147 VLSLVVHHIAGDHWSAGVLFTDLLTAYRA---RSTGQRPSWAPLPV----QYADYSVWQS 1199 +L L +HHIAGD WS +L ++ T Y + + ++ AP Y D+ WQS Sbjct 131 ILLLTMHHIAGDMWSFDLLLSEFQTLYAKEVEQVSQEQIQTAPDSFTENKSYLDFVRWQS 190 Query 1200 ALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLA 1259 +L G Q YW +QL G L D PRP + + G +L + KL Sbjct 191 EMLSGSRGEKLWQ--YWQKQLAGELPILNLFADKPRPPVQTYQGTGYSLKLDEQLIQKLK 248 Query 1260 AVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRN 1319 ++ G + + +L AA V+L++ D+ IG+P+ GR + +++G+F+N++VLR Sbjct 249 CLALASGTSLYQVLLAAFYVLLYRYTNQTDILIGSPMRGRWGGDFKEIVGYFVNLMVLRT 308 Query 1320 DLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMP 1379 ++ N T E L + A HQD PF + E + P+R SR+PL + + Q Sbjct 309 SVQENATFTEFLAHISKTVKEAQKHQDYPFSLLAEQLEPERDPSRSPLCQVSFTWQRQRW 368 Query 1380 QDHVIDTGPDGDTTLRVLEPTFDAAQ--ADLSVNFFACGDEYRGHVI--YRTELYERATA 1435 + ++ + L ++P Q AD +N + + Y T+L+E +T Sbjct 369 CEQTENSLHSEEQVLE-MKPYLLGHQRGADFDLNLMVMEAQGVLQLCWQYNTDLFEASTI 427 Query 1436 QRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 R A V ++E P + + ++ +++ ++++L N Sbjct 428 TRIAGHFVTLLEGIVANPQKQIWQLPLLTEIEQQQLLVEWN 468 Score = 65.1 bits (157), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 30/81 (38%), Positives = 45/81 (56%), Gaps = 3/81 (3%) Query 1480 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYR 1539 ++Y+LD L+PVPVGV G++Y GG RP T +F+ +PF S+LY+ Sbjct 798 ANTQIYILDQNLQPVPVGVPGEIYLGGAGLAQGYFNRPELTKDKFIPNPF---DNSKLYK 854 Query 1540 NGERGVWKADGQLELLAEIER 1560 G+ + ADG +E L I+ Sbjct 855 TGDLAHYLADGNIEYLGRIDN 875 Score = 62.8 bits (151), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 28/81 (35%), Positives = 47/81 (59%), Gaps = 3/81 (3%) Query 1480 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYR 1539 ++Y+LD+ L+PVPVGV G+++ GG L RP T +F+++PF S+LY+ Sbjct 1889 ANTQIYILDEHLQPVPVGVAGELHIGGAGLARGYLNRPELTKEKFISNPFE---NSKLYK 1945 Query 1540 NGERGVWKADGQLELLAEIER 1560 G+ + DG +E + I+ Sbjct 1946 TGDLARYLPDGTIEYIERIDN 1966 Score = 56.6 bits (135), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 29/99 (30%), Positives = 52/99 (53%), Gaps = 1/99 (1%) Query 1462 MVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETA 1521 +V A+ + +I ++Y+LD L+PVP+G+ G+++ G L RP T Sbjct 4051 LVVAKEQDQISPSIGRAIANTQIYILDSNLQPVPIGIPGELHIAGVGLAKGYLNRPELTT 4110 Query 1522 TRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAEIER 1560 +F+ +PF + S+LY+ G+ + DG +E L I+ Sbjct 4111 EKFILNPF-DEGVSKLYKTGDLVRYLPDGNIEYLGRIDN 4148 Score = 55.8 bits (133), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 29/67 (44%), Positives = 40/67 (60%), Gaps = 1/67 (1%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHPVLC 1637 E L+ I A VL+V +VG YD+FF LGG S+LATQ+ +R R + L R +F P + Sbjct 3192 EEILSLIWAQVLKVEQVGIYDNFFELGGHSLLATQLISRVRTSLKVELPLRSLFAAPTVA 3251 Query 1638 ELAAAVD 1644 EL + Sbjct 3252 ELCQNIQ 3258 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/102 (30%), Positives = 46/102 (46%), Gaps = 21/102 (20%) Query 1480 GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGS---- 1535 A++Y+LD L+PVPVGV G++Y G RP T +F+ +PF G+ Sbjct 2969 ANAQIYILDKYLQPVPVGVPGELYIAGVLLSQGYFNRPELTLEKFIPNPFKRSRGAALRL 3028 Query 1536 -----------------RLYRNGERGVWKADGQLELLAEIER 1560 RLY+ G+ + +DG +E L I+ Sbjct 3029 RSVTDEQGSRGETFNSDRLYKTGDLARYLSDGNIEYLGRIDN 3070 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/91 (30%), Positives = 50/91 (55%), Gaps = 1/91 (1%) Query 1575 DTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEH 1633 +TE E+ +A I + LEV +VG Y++FF LGG S+L ++ + ++ G+ ++ +F + Sbjct 4274 NTEVEKIIAGIWQNTLEVEKVGIYNNFFELGGHSLLLIRINQQLQEKFGLEVSIVDMFNY 4333 Query 1634 PVLCELAAAVDAKPHVEAEPDDKHHAPMSTS 1664 P + L+ + K + E + P S S Sbjct 4334 PTIHRLSQYLSTKLNKEDTLKQNNSRPQSPS 4364 Score = 50.8 bits (120), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/90 (36%), Positives = 50/90 (56%), Gaps = 4/90 (4%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD-GGIPLTARMVFEHP 1634 T E LA + VL++ +VG +D+FF LGG S+LATQ+ +R R+ + L R +F Sbjct 2078 TPIEEILAQTWSQVLQLPQVGIHDNFFELGGHSLLATQLVSRIRNIFKVELPLRELFAAA 2137 Query 1635 VLCELAAAVDAKPHVEAEPDDKHHAPMSTS 1664 L ELA ++ ++ + AP+ TS Sbjct 2138 TLAELAREIE---QLQQQVLRLTSAPLGTS 2164 Score = 48.5 bits (114), Expect = 0.012, Method: Compositional matrix adjust. Identities = 26/66 (40%), Positives = 40/66 (61%), Gaps = 1/66 (1%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD-GGIPLTARMVFEHPVLC 1637 E LA + VL+V +G +D+FF LGG S+LATQ+ +R R+ + L R +F + Sbjct 1006 EEMLALLWTQVLKVELLGIHDNFFELGGHSLLATQLVSRIRNVFKLELPLRELFARATVA 1065 Query 1638 ELAAAV 1643 ELA ++ Sbjct 1066 ELAKSI 1071 >gi|226359675|ref|YP_002777453.1| non-ribosomal peptide synthetase [Rhodococcus opacus B4] gi|226238160|dbj|BAH48508.1| putative non-ribosomal peptide synthetase [Rhodococcus opacus B4] Length=9855 Score = 858 bits (2217), Expect = 0.0, Method: Compositional matrix adjust. Identities = 551/1528 (37%), Positives = 789/1528 (52%), Gaps = 88/1528 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ D S + N+ ++ R +G +D+ LR A+ AV RH LRT +P D Q Sbjct 2153 VWFLNQFDTSSPVYNLPLAVRFSGGLDVTALRRALRAVLHRHESLRTVFPASDSSPWQRI 2212 Query 61 V-HADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFC-APFELSRDAPLRITVVRTAADEH 118 + D+ T + TD A A R F A F+++ + P+R ++R DEH Sbjct 2213 LDEHDVDLDLTVVEATDAELAA--------AIRGFALAGFDVTTEIPVRARLLRVRNDEH 2264 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADL--------------------GPEH 158 VL+LV HHIA D S+ DL AY+ G DL G +H Sbjct 2265 VLVLVVHHIAADGWSFAPLSRDLMVAYAAHSGGRDLQWAPLPVQYADYTLWQRELLGEKH 2324 Query 159 RPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARV 218 P + + L YW +A P+ L+LP S A + + + R+ Sbjct 2325 DPDSRAA-----RQLAYWATTLAGLPDSLDLPTDRPRPSVASKHGATVSWEISTELHERL 2379 Query 219 ATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMR 277 T+A+ T +MV +A L+ R + + D + PV RG +D +G F NT+ +R Sbjct 2380 LTLARTQDTTLFMVAHSALSVLLSRLSATTDIAIGTPVAGRGDRDLDDLVGMFVNTLVLR 2439 Query 278 LRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPD 337 + A SF ELL R++ AFAH + +R+V LNP R + +V+ F+ Sbjct 2440 AQLDPASSFAELLQQVREVDLAAFAHTDVPFERLVEHLNPTRTAAHHPLFQVALFFQNHA 2499 Query 338 GGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAG------VLVEAEHLVEILEPALAKQ 391 PG+ + ++ L ++ R + E + E+ + + + Sbjct 2500 PAHLELPGLSVSSQPILPDVAAFDLQLVLTDTRDADGTPGPITAEFNYATELFDESTIRS 2559 Query 392 MLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVS--RGERFDTPVKTLVDLVNEQT 449 F +LD AP + +A+ AAR+RE+S D P TL DL Q Sbjct 2560 FGSQFVRILDAVTMAPHTPVGDIAI--AHPAARIRELSGWNATDHDVPDTTLPDLFGAQA 2617 Query 450 TRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGV 509 RTPDA AVV++G TY + +E +NRL +LI G+G E RVA+ + +S DL+V V Sbjct 2618 ARTPDAPAVVFDGASLTYREFDEHANRLARYLISCGVGPESRVALAMRRSLDLVVGMYAV 2677 Query 510 VKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP---------------VRELAGYRSD 554 VK+G YVPVDP +P DR+ ++L VL T +L+ + Sbjct 2678 VKAGGAYVPVDPDHPADRIGYVLQSAGPVCVLTTTADRGALPSGDVVTLDCLDLSDFSGA 2737 Query 555 DPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQ 614 TDADR+ PLR DNTAY+IYTSG+TG PKGVAVPH + +W + +Y + D +LQ Sbjct 2738 PVTDADRVYPLRADNTAYVIYTSGSTGKPKGVAVPHAAIVNQLLWMQSQYALTGRDVVLQ 2797 Query 615 VASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFL 674 + +FDVS+ F L GA +V+ P G D YL + + G+T FVPS+L +F+ Sbjct 2798 KTATTFDVSVWGFFWPLQVGAALVLAGPDGHRDPDYLARTIDELGVTVTDFVPSMLDVFV 2857 Query 675 SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQG 734 + +L+ V + GE LP E A +F A LHN YGPTE ++ + ++ Sbjct 2858 ASVPADSCSSLRHVFVIGEALPPETASRFRDLSSAGLHNLYGPTEAAVSVTYWE-TSDAD 2916 Query 735 TRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF 794 T VPIG P+ NT ++LD L PV GV GE+Y+GG +A GY R LT++RFVA+PF Sbjct 2917 TVTVPIGVPEWNTQAYVLDSRLHPVAAGVPGELYLGGVQLARGYLGRVDLTSDRFVANPF 2976 Query 795 -NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVV 853 G+RMYR+GDL RR DG +E++GR D QVK RG RIELG++ + P V A VV Sbjct 2977 GGAGARMYRTGDLVRRRRDGVLEYIGRTDFQVKFRGQRIELGEIETVLRSHPGVTGAAVV 3036 Query 854 VSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPIT 913 V G LV YV PA D D IR + +LP YM+P+A V+LDE P+ Sbjct 3037 VYSDATTGDHLVAYVVPA------PDRVADTAEIRRHASGSLPSYMVPSAVVLLDEFPLN 3090 Query 914 AHGKIDRAALPEPQIASD-TEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSL 972 GK+DR ALP P+ SD TE+ AP T+ ER +A +F +LG +RV DSFF+LGG+SL Sbjct 3091 TSGKLDRKALPAPEFTSDATEYVAPSTSVERAVASVFCAVLGLERVSVRDSFFELGGNSL 3150 Query 973 LATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSS 1032 +AT+LV+ +R V V VR++FE TV LA + RP L R + + LS Sbjct 3151 IATQLVSRLRGELDVPVTVRDLFETPTVAELAARLSQSTGADTRPALIRRERPERIPLSP 3210 Query 1033 SQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVP 1092 +Q R WF +FD + N+PFA GP D A AA+ D+V RHE LRTV+ + P Sbjct 3211 AQQRMWFLNQFDPSSPAYNLPFAVRFTGPLDRVALEAAVADLVERHESLRTVFPDSATGP 3270 Query 1093 HQIIQPPAEVPVRCAAGSDAAWLRAELNNERGYV--FDLETDWPIRAALLS-TPEQTVLS 1149 HQ+++ A+ P +D A E R + FD+ TD P+R LL + + VL+ Sbjct 3271 HQVVRDTADAPPNLTV-ADIAEDELETVLARFFTTGFDVTTDLPVRVTLLRVSAHEHVLA 3329 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGA--- 1206 LVVHHI GD WS + D++ AY AR+ G+RP+W PLPVQYADY++WQ LL D + Sbjct 3330 LVVHHICGDGWSMAPMVRDVMVAYTARTRGERPAWTPLPVQYADYALWQRELLGDESDPD 3389 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 + Q DYW L G+ E L D PRPA S G V+F + A+ LAA+++ Sbjct 3390 TLAARQLDYWTDTLAGIPDELELPTDHPRPAEQSYRGSHVDFDIDASAHRALAALAQSRR 3449 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 T FM++ A+AV+L + DV IG PVAGR E LD LIG F+N V LR + Sbjct 3450 ATLFMVMHTALAVLLGRLSASSDVTIGTPVAGRGEPELDDLIGMFVNTVALRTHVDPGSA 3509 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 +VL R + LAA++ D+PF+++VE ++P R +R+PLF +++ + +D Sbjct 3510 FTDVLDHVRDVDLAAFSRADVPFERLVEVLSPTRHAARHPLFQVMLTFQNLEQTALELD- 3568 Query 1387 GPDGDTTLRVLEPTFDAAQADLSVN----FFACG--DEYRGHVIYRTELYERATAQRFAD 1440 TLR L D A+ DL + F G D + Y T+L++ TA A Sbjct 3569 ----GLTLRGLGTDIDVAKFDLHLTLVERFDPAGRPDGMTAQLTYATDLFDADTADSIAA 3624 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQAR 1468 ++ A + ++ ++ A R Sbjct 3625 RFTTILGAVTTDATTRVGDIALLGADER 3652 Score = 852 bits (2200), Expect = 0.0, Method: Compositional matrix adjust. Identities = 553/1527 (37%), Positives = 815/1527 (54%), Gaps = 77/1527 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + N+ V+ R++G++DL ++ A+ + RH LRT YP DG Q Sbjct 7461 MWFINQFDTASPAYNLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVYPDSGDGPHQVI 7520 Query 61 V-HADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 V AD P DLT ++ + VLA F+++ D PLR + R AD++V Sbjct 7521 VPAADAVP-----DLTPVTAHPDDVLERVLAL--VTTGFDVTSDVPLRARMYRVGADDYV 7573 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRP--SAASG 165 L++VAHHI+ D S D+ AY+ G AD R + Sbjct 7574 LVMVAHHISGDGWSLAPLARDVMLAYTARTEGHVPLWTPLPVQYADYSLWQRELLGDEAD 7633 Query 166 PDTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 P++ A+ + YW + P+ L LP S R A + A T + T+A+ Sbjct 7634 PESVAAEQIAYWTRTLDGLPDRLSLPTDRPRPAVASHRGAHVPFTIDAATHRALLTLARG 7693 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVAMRLRPQSA 283 + +MV+ A L+ R ++ D V AP+ RG + D +G F NT+ +R A Sbjct 7694 RNTSLFMVMHTALAVLLARLSNESDIAVGAPIAGRGEESLDELVGMFVNTLVLRTHVDLA 7753 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 SF + L R AFAH I +R+V LNP R + +V+F F+ Sbjct 7754 SSFADSLNVARSTDLSAFAHSDIPFERLVDVLNPARSRSHHPLFQVAFSFQNLATATLEL 7813 Query 344 PGIECERYDLRSNITQLPLGFMV--EFDRAGV--LVEAE--HLVEILEPALAKQMLRHFG 397 PG+ E D+ + I+ L + + D G ++EA+ + ++ + + F Sbjct 7814 PGLHVEGLDVPNTISTFDLHLTLSEKHDADGTPDVIEAQFTYATDLFDDTTVRAFAERFT 7873 Query 398 VLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA 457 +L++ + PD + + L+ + + D P TL DL + Q RTPD A Sbjct 7874 RILESVVRDPDLAVGAIDLLGGAERQSVIAEFNDTAVDLPPTTLADLFSAQAVRTPDYPA 7933 Query 458 VVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV 517 V +EG TY + + + L H LI+ G+G + V + +++S +L+ V+++G Y+ Sbjct 7934 VFFEGTELTYSEFDRRVDALAHRLIDSGVGPDTVVGLAMNRSIELLAGMYAVLRAGGAYL 7993 Query 518 PVDPSYPQDRLDFILADCDAKLVLRT----------PVRE-----LAGYRSDDPTDADRI 562 P+D +P DRL ++L VL T PV E L G TDA R Sbjct 7994 PIDLGHPADRLAYVLETARPVCVLTTSPDGFTAENVPVIEIDTLDLTGSPRGPVTDAHRR 8053 Query 563 RPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDV 622 PLRP+NTAYLI+TSG+TG PKGVAV H +A W + EY +D TD ++Q +FD+ Sbjct 8054 APLRPENTAYLIFTSGSTGRPKGVAVSHAAIANQLRWKQHEYPLDTTDAVVQKTPVTFDL 8113 Query 623 SIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQW 682 S+ E+F L GAR+VI RP G D YL L+R + +T HFVPSLL F+ P + Sbjct 8114 SVWELFWPLMSGARLVISRPDGHRDPAYLADLMRQQRVTTAHFVPSLLEAFI--PDAGEQ 8171 Query 683 RTLQRVPIGGEPLPGEVADKFHATFDAL-LHNFYGPTETVINASRFKVVGPQGTRIVPIG 741 TL+RV GE LP + A +F + F ++ LHN YGPTE ++ + + T VPIG Sbjct 8172 PTLRRVLCIGEALPVDTAARFRSRFASVALHNLYGPTEAAVSVTAWTHTDVD-TDTVPIG 8230 Query 742 RPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-PGSRM 800 P+ NT +LD L PVP GV GE+Y+ G +A GY R LTAERFVA+PF PG+R+ Sbjct 8231 GPEWNTQAFVLDARLNPVPVGVAGELYLAGDQLARGYVARTDLTAERFVANPFGAPGARL 8290 Query 801 YRSGDLAR---RNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDL 857 YR+GD+ R R G +E++ R+D QVK+RGFRIELG++ +A+ VGQAVVV Sbjct 8291 YRTGDVVRWRIRGTTGVLEYLERSDFQVKVRGFRIELGEIESALIRSAGVGQAVVVAHRN 8350 Query 858 PRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGK 917 P G +LV YV P G VD + A V AA+P YM+PAA VVL E+P+TA+GK Sbjct 8351 PHTGTALVAYVVPEDGST------VDPTAVLADVGAAVPSYMVPAALVVLAELPLTANGK 8404 Query 918 IDRAALPEPQIASDT-EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 976 +DR ALP P AS E+RAP T TE +A ++ ++LG ++VG +FFDLGG+SL+AT+ Sbjct 8405 LDRKALPAPDFASAAAEYRAPATPTEEIVAAVYADVLGVEQVGTAANFFDLGGNSLVATR 8464 Query 977 LVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDS-ARPRLTRVDHDGPVRLSSSQM 1035 +VA + G V +R +FE V ALA +D+ D+ + RP LT + LSS+Q Sbjct 8465 VVARLSETLGRRVEIRSLFEAPAVGALAALLDSTDATAPTRPALTPAVRPELLPLSSAQQ 8524 Query 1036 RSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQI 1095 R WF RFD +AV+NIP A L G D +A A+ DV+ RHE LRT+Y + PHQ+ Sbjct 8525 RMWFLNRFDPDSAVHNIPVAVRLSGVLDVDALQHAVADVLHRHESLRTIYPDSADGPHQV 8584 Query 1096 IQPPAEVPVRCAA-GSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLVVH 1153 I V + +D A L A + + FD+ + P+R + + + VL++VVH Sbjct 8585 ILSTDRVGAETSVDAADEAALPALIADLVTTGFDVTAEVPVRVRIFRISATEHVLAVVVH 8644 Query 1154 HIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGA---GIVG 1210 HI+GD WS + D++ AY ARS G P WAPLPVQYADY++WQ LL D + Sbjct 8645 HISGDGWSMAPMVRDVMAAYSARSAGTSPDWAPLPVQYADYALWQRDLLGDETDPDSVAA 8704 Query 1211 PQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEF 1270 Q +W + L G + L D PRPA+ S G V+F + A + + +RD + F Sbjct 8705 RQLAFWTQTLAGAPDQLDLPTDRPRPAVASYRGGTVDFTVPADLHGTVVGAARDANASVF 8764 Query 1271 MLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREV 1330 M++ +A+AV+L + G D+ IG PVAGR E LD LIG F+N +VLR + G T E+ Sbjct 8765 MVVHSALAVLLSRLAGSGDISIGTPVAGRGERELDDLIGMFVNTLVLRQHVDGGRTFAEL 8824 Query 1331 LQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDG 1390 L R+ LAA++H D+PF+++VE VNP RS R+PLF +++ + + Q+ + G Sbjct 8825 LADVRETDLAAFSHADVPFERLVEVVNPSRSTGRHPLFQVMLTF-QNLDQESL----ELG 8879 Query 1391 DTTLRVLEPTFDAAQADLSVNFFACGDEYRG------HVIYRTELYERATAQRFADWLVR 1444 D ++ ++ D A+ DL + D G + Y +L++ +A F ++ Sbjct 8880 DLSVSGVDLDVDIAKFDLQLTLMEQFDSEGGPDGIAARLTYAADLFDEPSAHVFGQRFLQ 8939 Query 1445 VVEAFADRPDQPLREVEMVSAQARRRI 1471 V+ A D PD + +++++ R++I Sbjct 8940 VLRAAVDGPDTAVGDLDVLGRGERKQI 8966 Score = 828 bits (2139), Expect = 0.0, Method: Compositional matrix adjust. Identities = 544/1526 (36%), Positives = 779/1526 (52%), Gaps = 86/1526 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYP---VGDDGVA 57 MWF+ DPS N+ + R TG +D L AV + RH LRT +P G V Sbjct 3215 MWFLNQFDPSSPAYNLPFAVRFTGPLDRVALEAAVADLVERHESLRTVFPDSATGPHQVV 3274 Query 58 QPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADE 117 + T AD P T D+ + LE + R F F+++ D P+R+T++R +A E Sbjct 3275 RDT--ADAPPNLTVADIAED-------ELETVLARFFTTGFDVTTDLPVRVTLLRVSAHE 3325 Query 118 HVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRP--SAA 163 HVL LV HHI D S D+ AY+ G AD R Sbjct 3326 HVLALVVHHICGDGWSMAPMVRDVMVAYTARTRGERPAWTPLPVQYADYALWQRELLGDE 3385 Query 164 SGPDTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMA 222 S PDT A L+YW +A P+ LELP S+R + + A +A +A Sbjct 3386 SDPDTLAARQLDYWTDTLAGIPDELELPTDHPRPAEQSYRGSHVDFDIDASAHRALAALA 3445 Query 223 KNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQ 281 ++ T +MV+ A L+ R + S D + PV RG +D IG F NTVA+R Sbjct 3446 QSRRATLFMVMHTALAVLLGRLSASSDVTIGTPVAGRGEPELDDLIGMFVNTVALRTHVD 3505 Query 282 SAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGF 341 +F ++L RD+ AF+ + +R+V L+P R + +V F+ + Sbjct 3506 PGSAFTDVLDHVRDVDLAAFSRADVPFERLVEVLSPTRHAARHPLFQVMLTFQNLEQTAL 3565 Query 342 NPPGIECERYDLRSNITQ--LPLGFMVEFDRAG----VLVEAEHLVEILEPALAKQMLRH 395 G+ ++ + L L + FD AG + + + ++ + A + Sbjct 3566 ELDGLTLRGLGTDIDVAKFDLHLTLVERFDPAGRPDGMTAQLTYATDLFDADTADSIAAR 3625 Query 396 FGVLLDNALAAPDNTLSGLALM--DERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTP 453 F +L + +AL+ DER A L + P TL L + Q RTP Sbjct 3626 FTTILGAVTTDATTRVGDIALLGADERAALTLWNSTEHA---VPATTLPVLFDAQVARTP 3682 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 A A+V +G TY + +E +NRL +L+ G+G E RVA+ + +S DL+V VVK+G Sbjct 3683 GAPALVLDGASLTYREFDEHANRLARYLVSCGVGPESRVALAMRRSLDLVVGMYAVVKAG 3742 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTP---------------VRELAGYRSDDPTD 558 YVPVDP +P DR+ ++L VL T +L+ + TD Sbjct 3743 GAYVPVDPDHPADRIGYVLQSAGPVCVLTTAADRGALPSGDVVTLDCLDLSDFSGAPVTD 3802 Query 559 ADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP 618 ADR+ PLR DNTAY+IYTSG+TG PKGVAVPH + +W + +Y + D +LQ + Sbjct 3803 ADRVYPLRADNTAYVIYTSGSTGKPKGVAVPHAAIVNQLLWMQSQYALTGRDVVLQKTAT 3862 Query 619 SFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPG 678 +FDVS+ F L GA +V+ P G D YL + + G+T FVPS+L +F++ Sbjct 3863 TFDVSVWGFFWPLQVGAALVLAGPDGHRDPDYLARTIDELGVTVTDFVPSMLDVFVASVP 3922 Query 679 VSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIV 738 +L+ V + GE LP E A +F A LHN YGPTE ++ + ++ T V Sbjct 3923 ADSCSSLRHVFVIGEALPPETASRFRDLSSAGLHNLYGPTEAAVSVTYWE-TSDADTVTV 3981 Query 739 PIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NPG 797 PIG P+ NT ++LD L PV GV GE+Y+GG +A GY R LT++RFVA+PF G Sbjct 3982 PIGVPEWNTQAYVLDSRLHPVAAGVPGELYLGGVQLARGYLGRVDLTSDRFVANPFGGAG 4041 Query 798 SRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDL 857 +RMYR+GDL RR DG +E++GR D QVK RG RIELG++ + P V A VVV Sbjct 4042 ARMYRTGDLVRRRRDGVLEYIGRTDFQVKFRGQRIELGEIETVLRSHPGVTGAAVVVYSD 4101 Query 858 PRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGK 917 G LV YV PA D D IR + +LP YM+P+A V+LDE P+ GK Sbjct 4102 ATTGDHLVAYVVPA------PDRVADTAEIRRHASGSLPSYMVPSAVVLLDEFPLNTSGK 4155 Query 918 IDRAALPEPQIASD-TEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 976 +DR ALP P+ +SD TE+ AP+ E+ LA +F ++LG RVG DSFFDLGG+SL T+ Sbjct 4156 LDRKALPAPEFSSDATEYVAPRNEVEQALAGVFADVLGAGRVGVHDSFFDLGGNSLSVTR 4215 Query 977 LVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMR 1036 L A + G + VR++FE TV LA ID D RP LT + LS +Q R Sbjct 4216 LAARITETTGTRLSVRDVFEAPTVADLAVRIDPTARD-VRPALTAAPRPARIPLSLAQQR 4274 Query 1037 SWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQII 1096 W +FD + N+PFA L G DT A AAA DVV RHE LRTV+ + G P Q++ Sbjct 4275 MWLLNQFDADSPAYNLPFAVRLSGVVDTAALAAAFDDVVERHESLRTVFPDGGDGPEQVV 4334 Query 1097 QPPAEVPVRC-AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHH 1154 +V V A L + FD+ + P+RA L T P + VL++ +HH Sbjct 4335 LAVTDVSVTLPPVDVTEADLPGRMAALASRTFDVTAETPVRATLFRTAPTEHVLAISLHH 4394 Query 1155 IAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGP 1211 IA D WS G L D++ AY AR+ G P WAP VQYAD+SVWQ +L DD ++ Sbjct 4395 IAADGWSFGPLGRDVMVAYAARTDGHAPQWAPFEVQYADFSVWQRDVLGSEDDPESVLAT 4454 Query 1212 QRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFM 1271 Q +W R L G E L D PRPA + AG +V F + ++ +++RD G T FM Sbjct 4455 QLGFWTRTLAGAPDELPLPFDRPRPAQPTFAGGSVGFDIDPETHRRIRSLARDHGATTFM 4514 Query 1272 LLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVL 1331 + A A+++ + DV IG P+AGR E LD L+G F+N +VLR + G T E+L Sbjct 4515 VAHTAFALLMARLSATDDVAIGTPIAGRGERALDDLVGMFVNTLVLRTAVNGGATFAEML 4574 Query 1332 QRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGD 1391 + R LAA+AH D+PF+++V+A+ P R+ +R+P++ + + + D+ + Sbjct 4575 RTVRDTDLAAFAHADVPFERLVDALAPTRTAARHPIYQVALSMNPLQSPDYEL------- 4627 Query 1392 TTLRVLEPTFDAAQADLSVNFFACGDE---------YRGHVIYRTELYERATAQRFADWL 1442 LR+ D A + + G+E R IY T+L++ +T A L Sbjct 4628 PGLRIGVEDVDPGVAKIDLQ-LTLGEELDHTGAPSGMRAEFIYATDLFDESTISDVASRL 4686 Query 1443 VRVVEAFADRPDQPLREVEMVSAQAR 1468 R++EA PD + +++++ R Sbjct 4687 QRILEAVTSDPDTLVGDLDLLHDAER 4712 Score = 821 bits (2121), Expect = 0.0, Method: Compositional matrix adjust. Identities = 541/1518 (36%), Positives = 788/1518 (52%), Gaps = 75/1518 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + A I ++ R++G ID+A LR A+ V RH LRT YP ++G Q Sbjct 5338 MWFLNQFDTTAAAYTIPLALRMSGRIDVATLRTALGDVLARHEALRTVYPATENGAHQVI 5397 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V + P DLT + L +L R A F+++ D PLR+ + R + EHVL Sbjct 5398 VPVESIP----LDLTPTRLSGEDLSGAIL--RHASAGFDVTTDLPLRVHLFRESRSEHVL 5451 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------AD--LGPEHRPSAASGP 166 L V HHI+ D S+ +D+ +Y+ G AD + H + P Sbjct 5452 LFVVHHISADGWSFIPLASDVMTSYAARTAGDAPVWNALPVQYADYAMWQRHLLGDSDDP 5511 Query 167 DTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 + A + YW+ +A P+ + LP S A L L D ++ +A+ Sbjct 5512 QSLAASQIAYWKRTLAGLPDQVALPTDRPRPPAPSNLGGTARLTLDGDLHRQLHELARAH 5571 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVAMRLRPQSAM 284 + +MV+ A AL+ R D V V RG + D +G F NT+ +R Sbjct 5572 HASLFMVVHTALAALLSRLGAGPDVAVGTSVAGRGEQSLDGLVGMFVNTLVLRTDVHPDS 5631 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 + LL R + AF+H + +++V +NP R + +V+ + P Sbjct 5632 TGAALLEQVRRVDLEAFSHVEVPFEQLVDAINPTRSTAFHPLFQVALALQNLQTPTLELP 5691 Query 345 GIECERYDLRSNITQLPLGFMV------EFDRAGVLVEAEHLVEILEPALAKQMLRHFGV 398 G+E D+ S I + L F++ + + AG+ +E + ++ + A ++ F Sbjct 5692 GLEVSALDIESPIAKFDLNFVLGERHDEDGNPAGLDLELGYAKDLFDADTASRIGESFVR 5751 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV 458 +L P + L L+ + RL S G +T TLV L++EQ TP A AV Sbjct 5752 VLSGLAHDPRTPVGDLDLLGDDARLRLLAQSHGATRETVHSTLVGLLDEQVRATPSAPAV 5811 Query 459 VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVP 518 + TY + + +NRL LI G+G + VAV + +S DL+V VVK+G Y P Sbjct 5812 RWRDTALTYAEFDACANRLARKLIADGVGPDAVVAVEIPRSLDLLVAVHAVVKAGGAYTP 5871 Query 519 VDPSYPQDRLDFILADCDAKLVLRTP--VRELAGYRSD---------DPTD--------A 559 +DP P+ R I+ A LVL + +R+ R DP + A Sbjct 5872 LDPGQPEQRNRDIVEQSGASLVLTSSELLRQTGATRHGVRAIAPDALDPAEFGGEPIRAA 5931 Query 560 DRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPS 619 +RI PLRPDNTAY+++TSG+TG PKGVAV H + W + +Y + D +L + Sbjct 5932 ERIAPLRPDNTAYVLFTSGSTGRPKGVAVSHAAITAQLEWLREQYALGTADTMLLKTPVT 5991 Query 620 FDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGV 679 FDVS+ E F LA GAR+VI P G D YL ++R G+T +HFVP++L S PG+ Sbjct 5992 FDVSVWECFAPLAAGARLVIADPDGHRDPEYLAEIVRTHGVTVVHFVPAMLAALTSGPGL 6051 Query 680 SQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVP 739 + L+ V +GGE + E D F A+ A + N YGPTE + + F + VP Sbjct 6052 TDMPALRHVLVGGEAVSPETIDDFRASHPAEIDNTYGPTEAAVTTTFFAARS-DNSDTVP 6110 Query 740 IGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-PGS 798 IG P NT+ +LDD L+PVP GV GE+Y+GG +A GY R LTAERFVADPF+ G+ Sbjct 6111 IGLPVWNTSTLVLDDRLRPVPAGVAGELYLGGVQLARGYLGRPDLTAERFVADPFSTSGA 6170 Query 799 RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLP 858 R+YR+GDL R A G +E++GR D QVK+RGFRIELG++ +A+ V QAVVV P Sbjct 6171 RLYRTGDLVRWTAAGRLEYLGRTDFQVKVRGFRIELGEIVSALLRHEDVDQAVVVPHSDP 6230 Query 859 RLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKI 918 G+ LVGYV P V +D D + A A +LP YM+P+ V L E+P+T +GK+ Sbjct 6231 HTGEHLVGYVVPRGA------VALDCDAVLAEAAGSLPSYMVPSLLVPLTELPLTPNGKV 6284 Query 919 DRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLV 978 DR ALP P A E+ AP+T +ER +A +F ELLG RVG DD+FF+LGG+SL ATKL Sbjct 6285 DRNALPAPVFAGKAEYTAPRTESERVVAAVFAELLGVSRVGVDDNFFELGGNSLSATKLS 6344 Query 979 AAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSW 1038 + A + +R++F+ TV ALA +D +A LT G + LS +Q R W Sbjct 6345 TRIGVATQTRIAIRDVFDAPTVAALARRLDQHGPSTAIAPLTAAVRPGRIPLSLAQQRMW 6404 Query 1039 FNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP 1098 F +F+ + N+P A L G DT A AAAI D++ARHE LRTV+ + G PHQ+I Sbjct 6405 FLNQFETSSPAYNLPAAVRLTGSLDTAALAAAIGDLIARHESLRTVFPDSRGGPHQVILE 6464 Query 1099 PAE-VPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIA 1156 P + P LRA+L FD+ P+R + S P + VL+LVVHHI+ Sbjct 6465 PGDFTPDVAPVHVSETGLRADLQEFLLAGFDVSEAVPLRVKVYSLGPAEHVLALVVHHIS 6524 Query 1157 GDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGPQR 1213 D S L D++ AY +R+ G P+WAPLPVQYADY++WQ +L + + Q Sbjct 6525 ADGASMEPLIRDVMIAYGSRAAGHPPTWAPLPVQYADYALWQRTVLGSESEPGSLAAAQL 6584 Query 1214 DYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLL 1273 DYW R L G+ + L D RPA+ + G A F L A L ++R G + FM+ Sbjct 6585 DYWTRALAGVPDQLYLPGDRGRPAVPTHRGAATRFTLDAGTHRALTELARAHGASLFMVA 6644 Query 1274 QAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQR 1333 AA++V+L + D+ +G VAGR LD +IG F+N +VLR L + +L + Sbjct 6645 HAALSVLLGRLSTTADIAVGTAVAGRGRVELDDIIGMFVNTLVLRTTLDPGASFVALLAQ 6704 Query 1334 TRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTT 1393 TR + L A+AH DLPF+++VE ++P RS S +PLF + + V+ +D Sbjct 6705 TRTVDLEAFAHADLPFERLVEVLSPVRSTSHHPLFQVALGVQAVSADGLELD-------G 6757 Query 1394 LRVLEPTFDAAQADLSVNF--------FACGDEYRGHVIYRTELYERATAQRFADWLVRV 1445 L V T DA+ A ++F A +IY T++++ +TA +A L R+ Sbjct 6758 LSVTPLTLDASIAKFDLHFTLTERLDDTAEPAGIDAELIYATDIFDESTAAGYATRLRRI 6817 Query 1446 VEAFADRPDQPLREVEMV 1463 EA P +P+ ++ ++ Sbjct 6818 FEAVVADPQRPIGDIPVL 6835 Score = 802 bits (2071), Expect = 0.0, Method: Compositional matrix adjust. Identities = 545/1535 (36%), Positives = 788/1535 (52%), Gaps = 90/1535 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + A N+ ++ R+ G +D LR A+ V RH LRT +P DG Sbjct 1097 MWFLNQFDTASAAYNLPIALRLAGALDREALRAALGDVQERHEALRTVFPDSADGP---- 1152 Query 61 VHADLRPGWTQYDLTD-LSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 H ++P + TD L + L V A F+L+ D PLR + R A + HV Sbjct 1153 -HQLIKPAVSVLADTDPLDVDPESLTAAVTALG--STGFDLTADTPLRAGLFREAPERHV 1209 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQA---------------------YS--RADLGADLGP 156 L+LV HHIA D S D+ A YS + DL LG Sbjct 1210 LVLVVHHIAADGWSMTPLAADVMVAYAARAAGHAPIWAPLPVQYVDYSLWQRDL---LGS 1266 Query 157 EHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAA 216 E P++ S + +WRA +A P+ +ELP S R R +PAD Sbjct 1267 EDDPNSLSA-----KQIAHWRAALAGVPQLIELPTDRTRPAEMSHRGGRVEFTIPADVHG 1321 Query 217 RVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTED-AIGYFGNTVA 275 R+ +A++TG TP+MV AA L+ R D ++ PV RG D +G F NT+A Sbjct 1322 RLVDLAQSTGTTPFMVTHAALAVLLRRLGAGSDIVIGTPVAGRGEEALDHLVGMFVNTLA 1381 Query 276 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFRE 335 +R +F ++L TR AF H + +R+V L+P R + +V F+ Sbjct 1382 LRTTVDLGDTFEDVLARTRAADLAAFQHGDVPFERLVEVLSPARSSAHHPLFQVMLTFQN 1441 Query 336 PDGGGFNPPGIECERYDLRSNITQLPLGFMVEFD------RAGVLVEAEHLVEILEPALA 389 G+E E ++ + + L V + AG+ V+ + ++ + + Sbjct 1442 TANTRVELDGLEVEAAEIDVQVAKFDLHLTVAENVDAAGNAAGLAVQLSYATDLFDHSTV 1501 Query 390 KQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQT 449 + FG LLD P + L L+D R+ A L + R P TL L Q Sbjct 1502 VSIGERFGRLLDAVSGNPPVAVGDLDLLDSREHAALTAANATHR-PVPADTLASLFAAQA 1560 Query 450 TRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGV 509 TPDA A+V++ + TY + +E ++RL LI G+G E VAV + +S DL+V + Sbjct 1561 AATPDAVALVFDDRRLTYAEFDERTDRLARHLIRTGVGPESVVAVGMRRSIDLLVAVYAI 1620 Query 510 VKSGAVYVPVDPSYPQDRLDFILADCDAKLVLR-----TPVRELAGYRSDDPTDADRIRP 564 VK+GA Y+P+DP +P +R ++L VL T R A + D D P Sbjct 1621 VKAGAAYLPIDPDHPAERTAYVLDTAQPVCVLTRAADDTTFRTAAPVVNIDTLDLPDQDP 1680 Query 565 ------LRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP 618 L NTAY+I+TSG+TG PKGVAV H + +W + EY + D ++Q Sbjct 1681 TPISTALTAGNTAYVIFTSGSTGRPKGVAVTHGAIVNRLLWMQHEYGLTPDDAVMQKTPV 1740 Query 619 SFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPG 678 +FDVS+ E+F L GA MVI P G D YL L+R +T MHFVPS+L +F + P Sbjct 1741 TFDVSVWELFWPLQVGASMVIAAPDGHRDPDYLATLIRRHRVTTMHFVPSMLSVFTAEPA 1800 Query 679 VSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIV 738 V+ +L+ V GE L E +F A A LHN YGPTE ++ + ++ G V Sbjct 1801 VAVCDSLRLVFCSGEALTPEQVSRFRAVSGAGLHNLYGPTEAAVDVTYWET-GAADALSV 1859 Query 739 PIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGS 798 PIGRP NT +H+LD L PVP GV GE+Y+ G +A GY RA L+++RFVA+PF G Sbjct 1860 PIGRPVWNTQVHVLDARLHPVPNGVAGEVYLAGDQLARGYLNRADLSSDRFVANPFVAGG 1919 Query 799 RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLP 858 RMYR+GDL RR DG +E++GR D QVK+RG RIELG++ +A+ P V QAVVVV Sbjct 1920 RMYRTGDLVRRRGDGALEYLGRTDFQVKLRGQRIELGEIESALEAHPDVVQAVVVVHRDE 1979 Query 859 RLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKI 918 R ++LV Y+ + +RA ++ +P YM+PA V LD +P++ +GK+ Sbjct 1980 RGDEALVAYLV--------GRRAAEWSDVRAHLSTRVPSYMIPARVVHLDTLPLSVNGKL 2031 Query 919 DRAALPEPQIASDT-EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKL 977 DR ALP P + + T E+ APQT E +A +F E+LG +RVG D FFDLGG+SL+AT+L Sbjct 2032 DRKALPPPTLDTATAEYIAPQTPAEVVVAGVFAEILGVERVGTHDHFFDLGGNSLVATRL 2091 Query 978 VAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGP--VRLSSSQM 1035 V+ +R A GV V +R++F+ TV ALA +D +D + + P V LS +Q Sbjct 2092 VSRLRIALGVPVSLRDVFDAPTVGALAHRLDRVDPAAHPAPPALTPQERPEQVPLSPAQQ 2151 Query 1036 RSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQI 1095 R WF +FD + V N+P A G D A A+ V+ RHE LRTV+ P Q Sbjct 2152 RVWFLNQFDTSSPVYNLPLAVRFSGGLDVTALRRALRAVLHRHESLRTVFPASDSSPWQR 2211 Query 1096 I--QPPAEVPVRCAAGSDAAWLRAELNNERGYV---FDLETDWPIRAALLST-PEQTVLS 1149 I + ++ + +DA A RG+ FD+ T+ P+RA LL ++ VL Sbjct 2212 ILDEHDVDLDLTVVEATDAELAAA----IRGFALAGFDVTTEIPVRARLLRVRNDEHVLV 2267 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGA 1206 LVVHHIA D WS L DL+ AY A S G+ WAPLPVQYADY++WQ LL D Sbjct 2268 LVVHHIAADGWSFAPLSRDLMVAYAAHSGGRDLQWAPLPVQYADYTLWQRELLGEKHDPD 2327 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 Q YW L GL L D PRP++ S G V + + + ++L ++R Sbjct 2328 SRAARQLAYWATTLAGLPDSLDLPTDRPRPSVASKHGATVSWEISTELHERLLTLARTQD 2387 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 T FM+ +A++V+L + D+ IG PVAGR + +LD L+G F+N +VLR L + Sbjct 2388 TTLFMVAHSALSVLLSRLSATTDIAIGTPVAGRGDRDLDDLVGMFVNTLVLRAQLDPASS 2447 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 E+LQ+ R++ LAA+AH D+PF+++VE +NP R+ + +PLF + + + P + Sbjct 2448 FAELLQQVREVDLAAFAHTDVPFERLVEHLNPTRTAAHHPLFQVALFFQNHAPAHLEL-- 2505 Query 1387 GPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVI----YRTELYERATAQRFADWL 1442 P + + + P A L + D G + Y TEL++ +T + F Sbjct 2506 -PGLSVSSQPILPDVAAFDLQLVLTDTRDADGTPGPITAEFNYATELFDESTIRSFGSQF 2564 Query 1443 VRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 VR+++A P P+ ++ + AR R L NA Sbjct 2565 VRILDAVTMAPHTPVGDIAIAHPAARIRELSGWNA 2599 Score = 741 bits (1914), Expect = 0.0, Method: Compositional matrix adjust. Identities = 541/1544 (36%), Positives = 764/1544 (50%), Gaps = 108/1544 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ + S N+ + R+TG +D A L A+ + RH LRT +P G Q Sbjct 6403 MWFLNQFETSSPAYNLPAAVRLTGSLDTAALAAAIGDLIARHESLRTVFPDSRGGPHQ-- 6460 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 L PG D+ + LR ++ Q A F++S PLR+ V EHVL Sbjct 6461 --VILEPGDFTPDVAPVHVSETGLRADL--QEFLLAGFDVSEAVPLRVKVYSLGPAEHVL 6516 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------AD--------LGPEHRP 160 LV HHI+ D S D+ AY G AD LG E P Sbjct 6517 ALVVHHISADGASMEPLIRDVMIAYGSRAAGHPPTWAPLPVQYADYALWQRTVLGSESEP 6576 Query 161 SAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVAT 220 + + A L+YW +A P+ L LPG G + R A L A T + Sbjct 6577 GSLAA-----AQLDYWTRALAGVPDQLYLPGDRGRPAVPTHRGAATRFTLDAGTHRALTE 6631 Query 221 MAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLR 279 +A+ G + +MV AA L+ R + + D V V RG +D IG F NT+ +R Sbjct 6632 LARAHGASLFMVAHAALSVLLGRLSTTADIAVGTAVAGRGRVELDDIIGMFVNTLVLRTT 6691 Query 280 PQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGG 339 SF LL TR + AFAH + +R+V L+P R + +V+ G + Sbjct 6692 LDPGASFVALLAQTRTVDLEAFAHADLPFERLVEVLSPVRSTSHHPLFQVALGVQAVSAD 6751 Query 340 GFNPPGIECERYDLRSNITQLPLGFMVE------FDRAGVLVEAEHLVEILEPALAKQML 393 G G+ L ++I + L F + + AG+ E + +I + + A Sbjct 6752 GLELDGLSVTPLTLDASIAKFDLHFTLTERLDDTAEPAGIDAELIYATDIFDESTAAGYA 6811 Query 394 RHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTP 453 + + +A P + + ++ E + A L V + PV+ L +++ + P Sbjct 6812 TRLRRIFEAVVADPQRPIGDIPVLGEDEHAALTPVRGAD--PRPVQMLPEILADAVAAAP 6869 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 D AVV++G TY DL+E SN+L L+++G+G E VA+ L +S + +V V K+G Sbjct 6870 DGLAVVFDGAGLTYRDLDERSNQLARLLVDRGVGPETSVALALPRSFESVVAVWAVAKTG 6929 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTPVR------ELAGYRSDDP----------- 556 A +VPVDP YP DR+ ++ D A + + + + DDP Sbjct 6930 AAFVPVDPGYPADRIVHMVQDSGAMVGITVSAKRALLPDSIRWMLLDDPALEVRCTHESR 6989 Query 557 ---TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLL 613 T+ DR+RP+ D AY+IYTSG+TG PKGVAV HR + + V R L Sbjct 6990 LPLTNRDRMRPILSDQVAYVIYTSGSTGRPKGVAVTHRGLMNLVTDERELLAVTSRSRTL 7049 Query 614 QVASPSFDVSIAEIFGTLACGARMVIPRP---GGLTDIGYLTALLRDEGITAMHFVPSLL 670 ASPSFD S+ E+ L GA MVI P GG L LL E IT P+ L Sbjct 7050 HFASPSFDASVFEMLMALGAGATMVIAPPTIYGG----SELAELLAAERITHAFSTPAAL 7105 Query 671 GLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVV 730 + G+ + L V + G+ P E+ ++ L N YGP+E I +S + + Sbjct 7106 A-SVDHHGLDE---LAVVVVAGDVCPPELVARWAP--GRRLVNAYGPSEATIMSSITEPL 7159 Query 731 GPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFV 790 + V IG P +LD L+PVP GV GE+Y+GG +A GY R GLTAERFV Sbjct 7160 --RAGEPVTIGGPSRGVRALVLDGRLRPVPVGVPGELYVGGPSLARGYLGRPGLTAERFV 7217 Query 791 ADPF-NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQ 849 ADP+ PG MYR+GDL R D ++FVGR D QVKIRGFRIELG++ AA+ P + Sbjct 7218 ADPYGEPGDLMYRTGDLVRWREDRVLDFVGRTDHQVKIRGFRIELGEIDAALTAHPQIEY 7277 Query 850 AVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDE 909 A + + P SLV YV P G D VD + V LP YM+PA+ +LD Sbjct 7278 ATTIGYEHPNGETSLVAYVLPFTGED------VDRVEVANFVGRTLPAYMVPASVTLLDA 7331 Query 910 IPITAHGKIDRAALPEP-QIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLG 968 +P+T GK+DR+ALPEP A+ T F AP+ E +A +F ++L +G DSFFDLG Sbjct 7332 LPLTPAGKLDRSALPEPIFAAAATTFEAPRNPMEVIVAGIFADILALPEIGIHDSFFDLG 7391 Query 969 GHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI-DTLDSDSARPRLTRVDHDGP 1027 G+SLLAT++V+ + A V VGVRE+FE TV ALA I +T + RP LT Sbjct 7392 GNSLLATQVVSRINAALDVHVGVREVFESPTVAALAARITETTTHGARRPALTARARPEH 7451 Query 1028 VRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYRE 1087 + LS +Q R WF +FD + N+P A L G D A AI D+V RHE LRTVY + Sbjct 7452 IPLSLAQQRMWFINQFDTASPAYNLPVALRLSGEVDLRAMQIAIADLVGRHEALRTVYPD 7511 Query 1088 IGGVPHQIIQPPAE-VP--VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-P 1143 G PHQ+I P A+ VP A D R G FD+ +D P+RA + Sbjct 7512 SGDGPHQVIVPAADAVPDLTPVTAHPDDVLERVLALVTTG--FDVTSDVPLRARMYRVGA 7569 Query 1144 EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLD 1203 + VL +V HHI+GD WS L D++ AY AR+ G P W PLPVQYADYS+WQ LL Sbjct 7570 DDYVLVMVAHHISGDGWSLAPLARDVMLAYTARTEGHVPLWTPLPVQYADYSLWQRELLG 7629 Query 1204 DGA---GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 D A + Q YW R L GL L D PRPA+ S G V F + AA L Sbjct 7630 DEADPESVAAEQIAYWTRTLDGLPDRLSLPTDRPRPAVASHRGAHVPFTIDAATHRALLT 7689 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 ++R + FM++ A+AV+L + D+ +GAP+AGR E +LD+L+G F+N +VLR Sbjct 7690 LARGRNTSLFMVMHTALAVLLARLSNESDIAVGAPIAGRGEESLDELVGMFVNTLVLRTH 7749 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE---- 1376 + + + L R L+A+AH D+PF+++V+ +NP RS S +PLF + + Sbjct 7750 VDLASSFADSLNVARSTDLSAFAHSDIPFERLVDVLNPARSRSHHPLFQVAFSFQNLATA 7809 Query 1377 --QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACG--DEYRGHVIYRTELYER 1432 ++P HV G D T+ TFD LS A G D Y T+L++ Sbjct 7810 TLELPGLHV--EGLDVPNTIS----TFD-LHLTLSEKHDADGTPDVIEAQFTYATDLFDD 7862 Query 1433 ATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 T + FA+ R++E+ PD + ++++ R+ ++ N Sbjct 7863 TTVRAFAERFTRILESVVRDPDLAVGAIDLLGGAERQSVIAEFN 7906 Score = 708 bits (1827), Expect = 0.0, Method: Compositional matrix adjust. Identities = 513/1569 (33%), Positives = 770/1569 (50%), Gaps = 111/1569 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MW + D N+ + R++G +D A L A + V RH LRT +P G DG Q Sbjct 4275 MWLLNQFDADSPAYNLPFAVRLSGVVDTAALAAAFDDVVERHESLRTVFPDGGDGPEQVV 4334 Query 61 VH-ADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 + D+ D+T+ R+ LA R F +++ + P+R T+ RTA EHV Sbjct 4335 LAVTDVSVTLPPVDVTEADLPG---RMAALASRTF----DVTAETPVRATLFRTAPTEHV 4387 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGPD 167 L + HHIA D S+ D+ AY+ G AD R S D Sbjct 4388 LAISLHHIAADGWSFGPLGRDVMVAYAARTDGHAPQWAPFEVQYADFSVWQRDVLGSEDD 4447 Query 168 ---TTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 L +W +A P+ L LP ++ + +T R+ ++A++ Sbjct 4448 PESVLATQLGFWTRTLAGAPDELPLPFDRPRPAQPTFAGGSVGFDIDPETHRRIRSLARD 4507 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQSA 283 G T +MV AF L+ R + +DD + P+ RG +D +G F NT+ +R Sbjct 4508 HGATTFMVAHTAFALLMARLSATDDVAIGTPIAGRGERALDDLVGMFVNTLVLRTAVNGG 4567 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 +F E+L RD AFAH + +R+V L P R + +V+ + Sbjct 4568 ATFAEMLRTVRDTDLAAFAHADVPFERLVDALAPTRTAARHPIYQVALSMNPLQSPDYEL 4627 Query 344 PGIECERYDLRSNITQLPLGFMV--EFDR----AGVLVEAEHLVEILEPALAKQMLRHFG 397 PG+ D+ + ++ L + E D +G+ E + ++ + + + Sbjct 4628 PGLRIGVEDVDPGVAKIDLQLTLGEELDHTGAPSGMRAEFIYATDLFDESTISDVASRLQ 4687 Query 398 VLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA 457 +L+ + PD + L L+ DA R V R TL DL+ PD A Sbjct 4688 RILEAVTSDPDTLVGDLDLL--HDAERDALVPASGRPGLIPVTLPDLLAGAVRSNPDGDA 4745 Query 458 VVYEGQ-----HFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKS 512 +V G +Y L+ SNRL LI+ +G E VA+ L +S + +V V KS Sbjct 4746 LVAPGHGTSDGTLSYRALDATSNRLARLLIDLQVGPEVSVALALPRSRESVVATWAVTKS 4805 Query 513 GAVYVPVDPSYPQDRLDFILADCDAKLVLRTP--------------------VRELAGYR 552 GA +VPVDP+YP DR+ F+L DC A + + T + L Y Sbjct 4806 GAAFVPVDPNYPADRIAFMLEDCGAPIGITTAALRENLPDSTLWLVLDDDAVIEALTSYS 4865 Query 553 SDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRL 612 S+ D+DR+ L D+ AYLIYTSG+TG PKGVAV HR V + V R+ Sbjct 4866 SEPVQDSDRVAALSVDHPAYLIYTSGSTGRPKGVAVSHRGVVNLAADERVRLGVLSESRV 4925 Query 613 LQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGL 672 L ASPSFD S+ E+ ++ GA +V+ P + L L ++ ++ P+ L Sbjct 4926 LHFASPSFDASVFELMMAVSAGATLVVA-PTTIFGGEELAEFLAEQEVSHAFCTPAALA- 4983 Query 673 FLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGP 732 ++ G+ +L V + G+ P E+ ++ ++ N YGP+E I +S + P Sbjct 4984 SVNHRGLD---SLTTVVVAGDVCPPELVARWAP--GRVMVNAYGPSEATIMSSATGPLVP 5038 Query 733 QGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVAD 792 + V IG P + + +LD L+PVP GV GE+Y+ G+ +A GY RR+GLTAERFVA Sbjct 5039 G--QPVTIGSPTVGVDLVVLDSRLRPVPAGVRGELYVLGSSLARGYVRRSGLTAERFVAS 5096 Query 793 PFNPGSRMYRSGDLARRNADGD----IEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVG 848 PF G RMYR+GD+ R D +EF+GR+D QVKIRGFRIELG++ AA+ P V Sbjct 5097 PFGSGGRMYRTGDVVRWVTAPDRPPVLEFLGRSDFQVKIRGFRIELGEIDAALTAHPVVE 5156 Query 849 QAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLD 908 A + D LV YV PA + VD + V LP YM+P++ +VLD Sbjct 5157 FAHTIGFDDGSGHDRLVSYVLPAPAAE------VDSRVLSEFVGERLPGYMVPSSIMVLD 5210 Query 909 EIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLG 968 +P+T GK+DR ALP P A +EF APQT E+ +A +F +++G +G DD+FFDLG Sbjct 5211 SLPLTPAGKLDRNALPTPVFAQRSEFTAPQTPAEQAIAAVFADVVGEPSIGLDDNFFDLG 5270 Query 969 GHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPV 1028 G+SL AT++V+ V +A G + VR +F+ TV ALA + + RP L + + Sbjct 5271 GNSLSATQVVSRVGSALGTRISVRTLFDNPTVRALATAAASDTTAE-RPALVAGERPATI 5329 Query 1029 RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 LS +Q R WF +FD A IP A + G D A+ DV+ARHE LRTVY Sbjct 5330 PLSPAQQRMWFLNQFDTTAAAYTIPLALRMSGRIDVATLRTALGDVLARHEALRTVYPAT 5389 Query 1089 GGVPHQIIQPPAEVPVRCA----AGSDAAWLRAELNNERGYVFDLETDWPIRAALL-STP 1143 HQ+I P +P+ +G D L + FD+ TD P+R L + Sbjct 5390 ENGAHQVIVPVESIPLDLTPTRLSGED---LSGAILRHASAGFDVTTDLPLRVHLFRESR 5446 Query 1144 EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL- 1202 + VL VVHHI+ D WS L +D++T+Y AR+ G P W LPVQYADY++WQ LL Sbjct 5447 SEHVLLFVVHHISADGWSFIPLASDVMTSYAARTAGDAPVWNALPVQYADYAMWQRHLLG 5506 Query 1203 --DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 DD + Q YW R L GL + L D PRP S G L + +L Sbjct 5507 DSDDPQSLAASQIAYWKRTLAGLPDQVALPTDRPRPPAPSNLGGTARLTLDGDLHRQLHE 5566 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 ++R + FM++ A+A +L + G G DV +G VAGR E +LD L+G F+N +VLR D Sbjct 5567 LARAHHASLFMVVHTALAALLSRLGAGPDVAVGTSVAGRGEQSLDGLVGMFVNTLVLRTD 5626 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE-QMP 1379 + + T +L++ R++ L A++H ++PF+Q+V+A+NP RS + +PLF + + ++ Q P Sbjct 5627 VHPDSTGAALLEQVRRVDLEAFSHVEVPFEQLVDAINPTRSTAFHPLFQVALALQNLQTP 5686 Query 1380 QDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRG---------HVIYRTELY 1430 + L V ++ A +NF G+ + + Y +L+ Sbjct 5687 TLEL--------PGLEVSALDIESPIAKFDLNFV-LGERHDEDGNPAGLDLELGYAKDLF 5737 Query 1431 ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGA----GTARVYL 1486 + TA R + VRV+ A P P+ +++++ AR R+L +S+ + V L Sbjct 5738 DADTASRIGESFVRVLSGLAHDPRTPVGDLDLLGDDARLRLLAQSHGATRETVHSTLVGL 5797 Query 1487 LDDALKPVP 1495 LD+ ++ P Sbjct 5798 LDEQVRATP 5806 Score = 602 bits (1553), Expect = 1e-169, Method: Compositional matrix adjust. Identities = 501/1526 (33%), Positives = 725/1526 (48%), Gaps = 98/1526 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARR--HRILRTTYPVGDDGVAQ 58 MWF Q DPS + I + G +D+A L +++ R LR V DGV Sbjct 45 MWFAQQLDPS-VPVTIAQCVELVGALDVALLSESLITAGRELGSAFLRL---VEVDGVPY 100 Query 59 PTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 + L + DL + R ++E+ P ++ RD + V+R + H Sbjct 101 QLIDPTLEASVSVVDLQ--HEPDPRAAATEWMRQEYTTPLDVCRDRLVTSAVLRIGPNHH 158 Query 119 VLLLVAHHIAWDDGSWRVFFTDLT-QAYSRADLGADLGPEHRPSAASGPDTTE------- 170 HH+A D G V D T + Y+ A G + P AA D Sbjct 159 YWYCRVHHVALD-GMGSVTLVDRTAELYTAAVEGRAVAPS---KAAELTDVARVDDEYRT 214 Query 171 -----ADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 AD YW ++ EP L P R+ ++ A + Sbjct 215 SSRYLADGEYWSERVSSIGEPHSL---VDRTAPARARSRTTGGQILGPLADHLDAATNRH 271 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAM 284 + ++AAF A + R T ++ V+ PV R A + G N V +RL + M Sbjct 272 DSSAAFEVIAAFAAYLARMTGREEVAVSLPVTARTTALLRRSGGMVSNVVPLRLDVRPDM 331 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 + +L+ A R +GA HQR + R+ D + + V E G Sbjct 332 TNTDLVAAVRLEVTGALRHQRYPHMDIRRDAATDHQGFYGPLINVMLFHNEITLGSI--- 388 Query 345 GIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVE---ILEPALAK---QMLRHFGV 398 R +L S L V AG + + + ALA + R G Sbjct 389 ---VGRLELLSTGPISDLAVNVYHGVAGTSINLDLEANPDLYSDDALAAHHARFTRFLGA 445 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV 458 L + P + L ++DE D R+ + G PV L DL+ PD A+ Sbjct 446 FLTSDTGTP-RRIGDLEILDE-DECRILVPAAGRAGFAPVA-LPDLLAGAVRSNPDGDAL 502 Query 459 VYEGQ-----HFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 V G +Y L+E SNRL LI+ +G E VA+ L +S + + + V KSG Sbjct 503 VAPGHGTPDVTLSYRALDEESNRLARLLIDLQVGPEVSVALALPRSVESVSSVWAVAKSG 562 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTP--------------------VRELAGYRS 553 A +VPVDP YP +R+ +L DC A + + T V +A Y + Sbjct 563 AAFVPVDPGYPFERIVHMLEDCGAPIGITTAALRAGLPDSTLWLVLDDDEFVSAVAAYPA 622 Query 554 DDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLL 613 D TDADR L D+ AY+IYTSG+TG PKGVAV HR V + V R+L Sbjct 623 DPVTDADRTGVLMVDHPAYVIYTSGSTGRPKGVAVSHRGVVNLAADERDRLGVSADSRVL 682 Query 614 QVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLF 673 ASPSFD S+ E+ + GA +V+ P + L L + ++ P+ L Sbjct 683 HFASPSFDASVFELVMAVCAGAALVVA-PTTMFGGVELAEFLAEHEVSHAFCTPAALA-S 740 Query 674 LSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQ 733 L G+ L V + G+ P E+ K+ ++ N YGPTET I +S + P Sbjct 741 LDHRGLDH---LTTVVVAGDVCPPELVAKWAP--GRIMVNAYGPTETTIMSSATGPMVPG 795 Query 734 GTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADP 793 + V IG + + +LD L+PVP GV GE+Y+ G+ +A GY RAGLTAERFVA P Sbjct 796 --QPVTIGSATVGVDLVVLDHRLRPVPVGVRGELYVLGSSLARGYVHRAGLTAERFVASP 853 Query 794 FNPGSRMYRSGDLARRNADGD----IEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQ 849 F G RMYR+GD+ R D +EF+GR+D QVKIRGFRIELG++ AA++ P V Sbjct 854 FGTGGRMYRTGDVVRWGTVPDGPPVLEFLGRSDFQVKIRGFRIELGEIDAALSAHPVVEF 913 Query 850 AVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDE 909 A V D LV YV PA G D V+ + V LP YM+P++ +VL+ Sbjct 914 AHTVGYDDGSGRSRLVSYVLPAPGTD------VETRVLSEFVGTRLPGYMVPSSIMVLNM 967 Query 910 IPITAHGKIDRAALPEPQIASDT-EFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLG 968 +P+T GK+DR ALP P A+ + + P+T +E L +F ++LG + D SFF+LG Sbjct 968 LPLTPAGKLDRNALPAPVFAARSADIVRPRTVSEEILLGIFRDVLGLPELSVDTSFFELG 1027 Query 969 GHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDS-ARPRLTRVDHDGP 1027 G+SL+AT++V+ V A V +GVR++F+ +V+ LA + S RP L + Sbjct 1028 GNSLMATQVVSRVNAALDVRIGVRDLFQSPSVSKLAATVANAGPQSDPRPALEPRERPDR 1087 Query 1028 VRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYRE 1087 + LS +Q R WF +FD +A N+P A L G D A AA+ DV RHE LRTV+ + Sbjct 1088 MPLSVAQQRMWFLNQFDTASAAYNLPIALRLAGALDREALRAALGDVQERHEALRTVFPD 1147 Query 1088 IGGVPHQIIQPPAEVPVRC-AAGSDAAWLRAELNNERGYVFDLETDWPIRAALL-STPEQ 1145 PHQ+I+P V D L A + FDL D P+RA L PE+ Sbjct 1148 SADGPHQLIKPAVSVLADTDPLDVDPESLTAAVTALGSTGFDLTADTPLRAGLFREAPER 1207 Query 1146 TVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL--- 1202 VL LVVHHIA D WS L D++ AY AR+ G P WAPLPVQY DYS+WQ LL Sbjct 1208 HVLVLVVHHIAADGWSMTPLAADVMVAYAARAAGHAPIWAPLPVQYVDYSLWQRDLLGSE 1267 Query 1203 DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVS 1262 DD + Q +W L G+ L D RPA +S G VEF + A + +L ++ Sbjct 1268 DDPNSLSAKQIAHWRAALAGVPQLIELPTDRTRPAEMSHRGGRVEFTIPADVHGRLVDLA 1327 Query 1263 RDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLR 1322 + G T FM+ AA+AV+L + G G D+ IG PVAGR E LD L+G F+N + LR + Sbjct 1328 QSTGTTPFMVTHAALAVLLRRLGAGSDIVIGTPVAGRGEEALDHLVGMFVNTLALRTTVD 1387 Query 1323 GNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDH 1382 T +VL RTR LAA+ H D+PF+++VE ++P RS + +PLF +++ + Sbjct 1388 LGDTFEDVLARTRAADLAAFQHGDVPFERLVEVLSPARSSAHHPLFQVMLTFQNTANTRV 1447 Query 1383 VIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDE--YRGHVIYRTELYERATAQRFAD 1440 +D + V FD ++ N A G+ + Y T+L++ +T + Sbjct 1448 ELDGLEVEAAEIDVQVAKFD-LHLTVAENVDAAGNAAGLAVQLSYATDLFDHSTVVSIGE 1506 Query 1441 WLVRVVEAFADRPDQPLREVEMVSAQ 1466 R+++A + P + +++++ ++ Sbjct 1507 RFGRLLDAVSGNPPVAVGDLDLLDSR 1532 Score = 566 bits (1459), Expect = 1e-158, Method: Compositional matrix adjust. Identities = 374/1049 (36%), Positives = 541/1049 (52%), Gaps = 62/1049 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ DP A+ NI V+ R++G +D+ L+ AV V RH LRT YP DG Q Sbjct 8526 MWFLNRFDPDSAVHNIPVAVRLSGVLDVDALQHAVADVLHRHESLRTIYPDSADGPHQVI 8585 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + D T D D + L L F+++ + P+R+ + R +A EHVL Sbjct 8586 LSTDRVGAETSVDAADEAA------LPALIADLVTTGFDVTAEVPVRVRIFRISATEHVL 8639 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP----------------SAAS 164 +V HHI+ D S D+ AYS G P+ P + Sbjct 8640 AVVVHHISGDGWSMAPMVRDVMAAYSARSAGT--SPDWAPLPVQYADYALWQRDLLGDET 8697 Query 165 GPDTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 PD+ A L +W +A P+ L+LP S+R +PAD V A+ Sbjct 8698 DPDSVAARQLAFWTQTLAGAPDQLDLPTDRPRPAVASYRGGTVDFTVPADLHGTVVGAAR 8757 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQS 282 + + +MV+ +A L+ R S D + PV RG +D IG F NT+ +R Sbjct 8758 DANASVFMVVHSALAVLLSRLAGSGDISIGTPVAGRGERELDDLIGMFVNTLVLRQHVDG 8817 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 +F ELL R+ AF+H + +R+V +NP R G + +V F+ D Sbjct 8818 GRTFAELLADVRETDLAAFSHADVPFERLVEVVNPSRSTGRHPLFQVMLTFQNLDQESLE 8877 Query 343 PPGIECERYDLRSNITQ--LPLGFMVEFDRAG----VLVEAEHLVEILEPALAKQMLRHF 396 + DL +I + L L M +FD G + + ++ + A + F Sbjct 8878 LGDLSVSGVDLDVDIAKFDLQLTLMEQFDSEGGPDGIAARLTYAADLFDEPSAHVFGQRF 8937 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPV--KTLVDLVNEQTTRTPD 454 +L A+ PD + L ++ ++++ PV TL L + PD Sbjct 8938 LQVLRAAVDGPDTAVGDLDVLGR---GERKQIAGTNATAHPVLAGTLASLFDTAVAADPD 8994 Query 455 ATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGA 514 AVV++ TY + + NRL LIEQG+G E VAV + +S DL+V VVK+G Sbjct 8995 RIAVVFDRDELTYANFDARVNRLARRLIEQGVGPESVVAVAMRRSIDLLVGIYAVVKAGG 9054 Query 515 VYVPVDPSYPQDRLDFIL---------------ADCDAKLVLRTPVRELAGYRSDDPTDA 559 Y+P+DP +P +R ++L AD + V+ +L+ Y S TD Sbjct 9055 AYLPIDPDHPVERTAYVLDTARPACVLVSGAGLADSGSVPVVDIASEDLSRYGSAPVTDR 9114 Query 560 DRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPS 619 DR+RPL NTAY+I+TSG+TG PKGVAV H + +W + EY + D +LQ + Sbjct 9115 DRLRPLTAANTAYVIFTSGSTGRPKGVAVTHGAIVNRLLWMQHEYALTSADVVLQKTPVT 9174 Query 620 FDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGV 679 FDVS+ E+F L GA MVI P G D YLT L+++ +T MHFVPS+L +F + P V Sbjct 9175 FDVSVWELFWPLQVGASMVIAAPDGHRDPRYLTGLVQERHVTTMHFVPSMLSVFTAEPAV 9234 Query 680 SQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVP 739 + +L+ V GE L E +F A LHN YGPTE ++ + F G T VP Sbjct 9235 AVCDSLRLVFCSGEALTPEQVSRFRGVSGAGLHNLYGPTEAAVDVT-FWETGESDTHSVP 9293 Query 740 IGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSR 799 IGRP NT +H+LD L PVP GV GE+Y+ G +A GY R LT++RFVA+PF G R Sbjct 9294 IGRPVWNTQVHVLDARLHPVPNGVAGELYLAGEQLARGYLGRVDLTSDRFVANPFVAGGR 9353 Query 800 MYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPR 859 MYR+GDL RR DG +E++GR D QVK+RG RIELG++ +A+ P V QAVVVV R Sbjct 9354 MYRTGDLVRRRGDGALEYLGRTDFQVKLRGQRIELGEIESALEAHPDVVQAVVVVHRDER 9413 Query 860 LGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKID 919 ++LV Y+ + +RA ++ +P YM+PA V LD +P++ +GK+D Sbjct 9414 GDEALVAYLV--------GRRAAEWSDVRAHLSTRVPSYMIPARVVHLDTLPLSVNGKLD 9465 Query 920 RAALPEPQIAS-DTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLV 978 R ALP P++ S E++ P++A ER +A +FGE+L DRVGA DSFFDLGG+SL+AT++ Sbjct 9466 RKALPAPEVRSAAAEYQPPRSAAERAVATVFGEVLEIDRVGATDSFFDLGGNSLIATRVA 9525 Query 979 AAVRNAFGVDVGVREIFEFATVTALAGHI 1007 AA+ + G+D ++ +F T +L I Sbjct 9526 AALGSELGIDFPLQWMFSDPTPRSLGQRI 9554 Score = 70.5 bits (171), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 37/74 (50%), Positives = 46/74 (63%), Gaps = 1/74 (1%) Query 1486 LLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGV 1545 +LDD L+PVP GV G++Y GG L RP TA RFVADPF+ G+RLYR G+ Sbjct 6122 VLDDRLRPVPAGVAGELYLGGVQLARGYLGRPDLTAERFVADPFSTS-GARLYRTGDLVR 6180 Query 1546 WKADGQLELLAEIE 1559 W A G+LE L + Sbjct 6181 WTAAGRLEYLGRTD 6194 Score = 65.1 bits (157), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 35/78 (45%), Positives = 47/78 (61%), Gaps = 1/78 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 + ++LD L PVPVGV G++Y G +AR TA RFVA+PF A PG+RLYR G+ Sbjct 8237 QAFVLDARLNPVPVGVAGELYLAGDQLARGYVARTDLTAERFVANPFGA-PGARLYRTGD 8295 Query 1543 RGVWKADGQLELLAEIER 1560 W+ G +L +ER Sbjct 8296 VVRWRIRGTTGVLEYLER 8313 Score = 63.5 bits (153), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 33/77 (43%), Positives = 45/77 (59%), Gaps = 1/77 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R +LD L+PVPVGV G++Y GG L RP TA RFVADP+ +PG +YR G+ Sbjct 7175 RALVLDGRLRPVPVGVPGELYVGGPSLARGYLGRPGLTAERFVADPY-GEPGDLMYRTGD 7233 Query 1543 RGVWKADGQLELLAEIE 1559 W+ D L+ + + Sbjct 7234 LVRWREDRVLDFVGRTD 7250 Score = 61.6 bits (148), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/84 (43%), Positives = 51/84 (61%), Gaps = 6/84 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD-GGIPLTARMVFEHP 1634 E E+ALA + ADVL G VG +D FF+LGG+S+ T++AAR + G L+ R VFE P Sbjct 4178 NEVEQALAGVFADVLGAGRVGVHDSFFDLGGNSLSVTRLAARITETTGTRLSVRDVFEAP 4237 Query 1635 VLCELAAAV-----DAKPHVEAEP 1653 + +LA + D +P + A P Sbjct 4238 TVADLAVRIDPTARDVRPALTAAP 4261 Score = 57.4 bits (137), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/79 (40%), Positives = 47/79 (60%), Gaps = 1/79 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T ERA+A++ VL + V D FF LGG+S++ATQ+ +R R + +P+T R +FE P Sbjct 3117 TSVERAVASVFCAVLGLERVSVRDSFFELGGNSLIATQLVSRLRGELDVPVTVRDLFETP 3176 Query 1635 VLCELAAAVDAKPHVEAEP 1653 + ELAA + + P Sbjct 3177 TVAELAARLSQSTGADTRP 3195 Score = 55.8 bits (133), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 32/77 (42%), Positives = 43/77 (56%), Gaps = 2/77 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVP GV G+VY G L R ++ RFVA+PF A G R+YR G+ Sbjct 1869 QVHVLDARLHPVPNGVAGEVYLAGDQLARGYLNRADLSSDRFVANPFVA--GGRMYRTGD 1926 Query 1543 RGVWKADGQLELLAEIE 1559 + DG LE L + Sbjct 1927 LVRRRGDGALEYLGRTD 1943 Score = 55.8 bits (133), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 32/77 (42%), Positives = 43/77 (56%), Gaps = 2/77 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVP GV G++Y G L R T+ RFVA+PF A G R+YR G+ Sbjct 9302 QVHVLDARLHPVPNGVAGELYLAGEQLARGYLGRVDLTSDRFVANPFVA--GGRMYRTGD 9359 Query 1543 RGVWKADGQLELLAEIE 1559 + DG LE L + Sbjct 9360 LVRRRGDGALEYLGRTD 9376 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/102 (43%), Positives = 61/102 (60%), Gaps = 9/102 (8%) Query 1548 ADGQLELLAEIERLPTAQAAPVPAE---PADTETERALAAILADVLEVGEVGRYDDFFNL 1604 A+G+L+ A LP A AE PA T TE +AA+ ADVL V +VG +FF+L Sbjct 8401 ANGKLDRKA----LPAPDFASAAAEYRAPA-TPTEEIVAAVYADVLGVEQVGTAANFFDL 8455 Query 1605 GGDSILATQVAARARDG-GIPLTARMVFEHPVLCELAAAVDA 1645 GG+S++AT+V AR + G + R +FE P + LAA +D+ Sbjct 8456 GGNSLVATRVVARLSETLGRRVEIRSLFEAPAVGALAALLDS 8497 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/66 (44%), Positives = 42/66 (64%), Gaps = 1/66 (1%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHPVLC 1637 E +A I AD+L + E+G +D FF+LGG+S+LATQV +R + + R VFE P + Sbjct 7365 EVIVAGIFADILALPEIGIHDSFFDLGGNSLLATQVVSRINAALDVHVGVREVFESPTVA 7424 Query 1638 ELAAAV 1643 LAA + Sbjct 7425 ALAARI 7430 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 98/395 (25%), Positives = 149/395 (38%), Gaps = 43/395 (10%) Query 1025 DGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTV 1084 DG LS++Q WF + D P+ I L G D + ++ + A E+ Sbjct 33 DGAFPLSAAQRGMWFAQQLD-PSVPVTIAQCVELVGALDVALLSESL--ITAGRELGSAF 89 Query 1085 YR--EIGGVPHQIIQPPAEVPVRC----------AAGSDAAWLRAELNNERGYVFDLETD 1132 R E+ GVP+Q+I P E V AA ++ W+R E D+ D Sbjct 90 LRLVEVDGVPYQLIDPTLEASVSVVDLQHEPDPRAAATE--WMRQEYTTP----LDVCRD 143 Query 1133 WPIRAALLST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQR--PSWAPLPV 1189 + +A+L P VHH+A D + L Y A G+ PS A Sbjct 144 RLVTSAVLRIGPNHHYWYCRVHHVALDGMGSVTLVDRTAELYTAAVEGRAVAPSKAAELT 203 Query 1190 QYA---DYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV 1246 A D S L DG +YW ++ + GE D PA Sbjct 204 DVARVDDEYRTSSRYLADG--------EYWSERVSSI-GEPHSLVDRTAPARARSRTTGG 254 Query 1247 EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQ 1306 + LG AA +R F ++ AA A L + G +V + PV R+ A L + Sbjct 255 QI-LGPLADHLDAATNRHDSSAAFEVI-AAFAAYLARMTGREEVAVSLPVTARTTALLRR 312 Query 1307 LIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNP 1366 G N+V LR D+R + T +++ R A HQ P + P Sbjct 313 SGGMVSNVVPLRLDVRPDMTNTDLVAAVRLEVTGALRHQRYPHMDIRRDAATDHQGFYGP 372 Query 1367 LFDIVVHVRE-----QMPQDHVIDTGPDGDTTLRV 1396 L ++++ E + + ++ TGP D + V Sbjct 373 LINVMLFHNEITLGSIVGRLELLSTGPISDLAVNV 407 Score = 53.5 bits (127), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/70 (40%), Positives = 46/70 (66%), Gaps = 1/70 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T E +A + A++L V VG +D FF+LGG+S++AT++ +R R G+P++ R VF+ P Sbjct 2053 TPAEVVVAGVFAEILGVERVGTHDHFFDLGGNSLVATRLVSRLRIALGVPVSLRDVFDAP 2112 Query 1635 VLCELAAAVD 1644 + LA +D Sbjct 2113 TVGALAHRLD 2122 Score = 52.4 bits (124), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 35/99 (36%), Positives = 52/99 (53%), Gaps = 6/99 (6%) Query 1562 PTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR-ARD 1620 P ++A +P + ERA+A + +VLE+ VG D FF+LGG+S++AT+VAA + Sbjct 9472 PEVRSAAAEYQPPRSAAERAVATVFGEVLEIDRVGATDSFFDLGGNSLIATRVAAALGSE 9531 Query 1621 GGIPLTARMVFEHPVLCELA-----AAVDAKPHVEAEPD 1654 GI + +F P L AA+D P A D Sbjct 9532 LGIDFPLQWMFSDPTPRSLGQRIQNAAIDGVPGAGASLD 9570 Score = 52.4 bits (124), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/77 (39%), Positives = 42/77 (55%), Gaps = 1/77 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 + Y+LD L PV GV G++Y GG L R T+ RFVA+PF G+R+YR G+ Sbjct 2930 QAYVLDSRLHPVAAGVPGELYLGGVQLARGYLGRVDLTSDRFVANPFGGA-GARMYRTGD 2988 Query 1543 RGVWKADGQLELLAEIE 1559 + DG LE + + Sbjct 2989 LVRRRRDGVLEYIGRTD 3005 Score = 52.4 bits (124), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/77 (39%), Positives = 42/77 (55%), Gaps = 1/77 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 + Y+LD L PV GV G++Y GG L R T+ RFVA+PF G+R+YR G+ Sbjct 3991 QAYVLDSRLHPVAAGVPGELYLGGVQLARGYLGRVDLTSDRFVANPFGGA-GARMYRTGD 4049 Query 1543 RGVWKADGQLELLAEIE 1559 + DG LE + + Sbjct 4050 LVRRRRDGVLEYIGRTD 4066 Score = 49.3 bits (116), Expect = 0.006, Method: Compositional matrix adjust. Identities = 29/73 (40%), Positives = 45/73 (62%), Gaps = 7/73 (9%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARM----VF 1631 TE+ER +AA+ A++L V VG D+FF LGG+S+ AT+++ R G+ R+ VF Sbjct 6305 TESERVVAAVFAELLGVSRVGVDDNFFELGGNSLSATKLSTRI---GVATQTRIAIRDVF 6361 Query 1632 EHPVLCELAAAVD 1644 + P + LA +D Sbjct 6362 DAPTVAALARRLD 6374 Score = 48.9 bits (115), Expect = 0.009, Method: Compositional matrix adjust. Identities = 25/62 (41%), Positives = 41/62 (67%), Gaps = 1/62 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T E+A+AA+ ADV+ +G D+FF+LGG+S+ ATQV +R G ++ R +F++P Sbjct 5241 TPAEQAIAAVFADVVGEPSIGLDDNFFDLGGNSLSATQVVSRVGSALGTRISVRTLFDNP 5300 Query 1635 VL 1636 + Sbjct 5301 TV 5302 Score = 48.5 bits (114), Expect = 0.011, Method: Compositional matrix adjust. Identities = 27/63 (43%), Positives = 35/63 (56%), Gaps = 2/63 (3%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 + +LD L+PVPVGV G++Y G + R TA RFVA PF G R+YR G+ Sbjct 809 LVVLDHRLRPVPVGVRGELYVLGSSLARGYVHRAGLTAERFVASPFGT--GGRMYRTGDV 866 Query 1544 GVW 1546 W Sbjct 867 VRW 869 Score = 47.8 bits (112), Expect = 0.021, Method: Compositional matrix adjust. Identities = 26/63 (42%), Positives = 35/63 (56%), Gaps = 2/63 (3%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 + +LD L+PVP GV G++Y G + R TA RFVA PF + G R+YR G+ Sbjct 5053 LVVLDSRLRPVPAGVRGELYVLGSSLARGYVRRSGLTAERFVASPFGS--GGRMYRTGDV 5110 Query 1544 GVW 1546 W Sbjct 5111 VRW 5113 Score = 45.4 bits (106), Expect = 0.10, Method: Compositional matrix adjust. Identities = 29/80 (37%), Positives = 44/80 (55%), Gaps = 2/80 (2%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T +E L I DVL + E+ FF LGG+S++ATQV +R + + R +F+ P Sbjct 998 TVSEEILLGIFRDVLGLPELSVDTSFFELGGNSLMATQVVSRVNAALDVRIGVRDLFQSP 1057 Query 1635 VLCELAAAV-DAKPHVEAEP 1653 + +LAA V +A P + P Sbjct 1058 SVSKLAATVANAGPQSDPRP 1077 >gi|325675434|ref|ZP_08155118.1| hypothetical protein HMPREF0724_12900 [Rhodococcus equi ATCC 33707] gi|325553405|gb|EGD23083.1| hypothetical protein HMPREF0724_12900 [Rhodococcus equi ATCC 33707] Length=6918 Score = 856 bits (2212), Expect = 0.0, Method: Compositional matrix adjust. Identities = 559/1524 (37%), Positives = 796/1524 (53%), Gaps = 76/1524 (4%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D NI ++ R++G++D+A L A+ V RH LRT +P DDG AQ Sbjct 5320 MWFLNRFDTESTAYNIPLALRMSGNLDVAALDLALADVTERHESLRTVFPATDDGPAQVI 5379 Query 61 V-HADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 + AD R T + D++ RL LA+ F +++ D P+R+ + RT AD V Sbjct 5380 LPAADAR---TPLRIVDVAPDDLPGRLRALAETRF----DVTSDVPIRVELYRTGADNFV 5432 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRP--SAASG 165 L +V HHI+ D S D+ AY+ G AD R + Sbjct 5433 LGMVVHHISADGVSLAPLTRDVMTAYAARTAGHAPGWTPLAVQYADYALWQREILGHETD 5492 Query 166 PDTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 P++ A L YW +A+ P+ L LP S+R + A T + +A+ Sbjct 5493 PESLAAQQLGYWSETLAELPDQLNLPTDHPRPAVQSFRGGLVEFEIDAPTHRALRDLARE 5552 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVAMRLRPQSA 283 T +M + +AF L+ R + SDD V P+ RG DA +G F NT+ R R A Sbjct 5553 QNATLFMAVHSAFAVLLSRLSGSDDIAVGTPIAGRGEAELDALVGMFVNTLVFRTRVDGA 5612 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 SF +L++ RD AFAH + +R+V LNP R + +V F F+ D G Sbjct 5613 RSFADLVSEVRDTDLEAFAHADVPFERLVEHLNPTRSTARHPLFQVGFSFQNHDTGALEL 5672 Query 344 PGIECERYDLRSNITQLPLGFMVE------FDRAGVLVEAEHLVEILEPALAKQMLRHFG 397 PG+ E ++ S + Q L +VE D G+ + +++ + + + F Sbjct 5673 PGLTVEAAEIESGVAQFDLHMIVEDHYDDGGDPTGMKASMTYALDLFDESTVRSFAERFA 5732 Query 398 VLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA 457 LL + P + + L+ + ARL T TLVDL + Q TPD A Sbjct 5733 RLLAAVVVKPTLPVGDVDLLGLEERARLLVERNDTATATARATLVDLFDAQVKATPDGIA 5792 Query 458 VVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV 517 +V + TY + NRL LI G+G E VA+ + +S DL+V V K+G YV Sbjct 5793 LVSGAERVTYAGFDARVNRLARRLIADGVGPESLVALSIRRSVDLLVGMYAVAKAGGAYV 5852 Query 518 PVDPSYPQDRLDFILADCDAKLVLRT----------PVRE-----LAGYRSDDPTDADRI 562 PVDP P DR +IL VL T PV E L + + DADR+ Sbjct 5853 PVDPDQPADRTGYILDAARPVCVLTTSRDGAAVASWPVLEIDTVDLDAFAATPVVDADRL 5912 Query 563 RPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDV 622 RPL NTAY+I+TSG+TG PKGVAVPH + +W + EY +D +D L + +FD+ Sbjct 5913 RPLDSRNTAYVIFTSGSTGRPKGVAVPHGAIVNQLLWMRDEYGLDASDAALLKTAATFDL 5972 Query 623 SIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQW 682 S+ E + T+ G R+VI P G D GYL +LRDE +T +H VPS+L + + G + Sbjct 5973 SVWEFWSTITSGGRLVIASPDGHRDPGYLLGVLRDEEVTTLHVVPSMLSMLTTTAGGTLP 6032 Query 683 RTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGR 742 +L+R+ GE LP A F A A+LHN YGPTE ++ + +V T +VPIG Sbjct 6033 PSLRRIFAIGEALPAATAQAFRADNTAVLHNLYGPTEAAVSVTHHEVTDAD-TVVVPIGV 6091 Query 743 PKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGSRMYR 802 P+ NT +++LD L PVP GV GE+Y+ G +A GYH RA LTA+RFVADP+ G RMYR Sbjct 6092 PEWNTRVYVLDSRLNPVPAGVTGELYLAGVQLARGYHGRADLTADRFVADPWATGERMYR 6151 Query 803 SGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLGK 862 +GD+ R NA ++E+V RAD QVK+RGFRIELG++ A + + +A V G Sbjct 6152 TGDVVRWNASDELEYVERADFQVKVRGFRIELGEIEAGLRELSGIREAAVTAHTDAHTGT 6211 Query 863 SLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRAA 922 LV Y+ AD +D + +A LP YM+P+AYVVLD +P+ A+GK+DR A Sbjct 6212 RLVAYLV--------ADADIDTATVNDALARTLPSYMVPSAYVVLDALPLNANGKLDRKA 6263 Query 923 LPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVR 982 LPEP + +FRA T E +A F ++LG +RVG DD FF+LGG+SL+AT+LVA + Sbjct 6264 LPEP-VFEARDFRAATTPIEEIVAGAFADVLGIERVGLDDDFFELGGNSLVATQLVARLG 6322 Query 983 NAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYR 1042 A V VR +FE +TV +AG + L RP LT V LS +Q R W + Sbjct 6323 AALDTQVPVRVVFEDSTVAGVAGAVTPLVGQGGRPALTARPRPPHVPLSLAQQRMWTLNQ 6382 Query 1043 FDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQP-PAE 1101 D +A NIP A L G D A+A+ DV+ARHE+L T Y + P Q++ P Sbjct 6383 VDTASAAYNIPVAVRLSGALDAGVLASAVADVIARHEVLHTTYPDTADGPAQVLVPLDRA 6442 Query 1102 VPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPE-QTVLSLVVHHIAGDHW 1160 VP A + L G FD+ + P+RAAL + + + VL+ V HHIA D + Sbjct 6443 VPRLQPIAVSEADVTDRLIEFLGRGFDVTAEVPVRAALFAVGQTEHVLAFVAHHIAADGF 6502 Query 1161 SAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGA---GIVGPQRDYWI 1217 S G L D++ AY AR G P W PL VQYADY++WQ +L D + V Q YW+ Sbjct 6503 SMGPLIRDVVLAYVARVDGGVPQWEPLGVQYADYTLWQREVLGDESDPDSAVARQIAYWV 6562 Query 1218 RQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAV 1277 +L G + L D PRPA S AG AV F + A + ++ +R+ G T FM+ AA+ Sbjct 6563 DELKGAPELSALPTDRPRPARPSLAGAAVPFAVDADLAARVEKTAREQGATTFMVFHAAL 6622 Query 1278 AVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQM 1337 A++L + GG D+ IG PVAGR +A LD LIG F+ + LR + + + ++L R Sbjct 6623 AILLSRLGGSNDITIGTPVAGRGDAALDDLIGMFVGTLALRTRVEPSASFADLLAHARTQ 6682 Query 1338 ALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRV- 1396 LAA+A+ D+PF+QVVEAV +R+ S +PLF +++ + + TG L V Sbjct 6683 DLAAFANADVPFEQVVEAVGVRRASSHSPLFQVMLTFQN-------MQTGTFALPGLEVS 6735 Query 1397 -LEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYERATAQRFADWLVRVVEAF 1449 L+ D ++ D+ V D+ G Y TEL++R T + FAD VR+++A Sbjct 6736 ALDLGADQSKFDVQVTAVEKFDQSGALTGIDGSFTYATELFDRETVEVFADRFVRILDAV 6795 Query 1450 ADRPDQPLREVEMVSAQARRRILD 1473 + P LR ++ V+ A R L+ Sbjct 6796 TENPSVVLRAID-VTTDAERAALE 6818 Score = 834 bits (2155), Expect = 0.0, Method: Compositional matrix adjust. Identities = 559/1533 (37%), Positives = 782/1533 (52%), Gaps = 94/1533 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D S A NI V+ R++G +D LR AV V RH LRT YP DGV Sbjct 3209 MWFLNRFDVSSAGNNIPVAVRLSGLLDRTALRAAVGDVIVRHESLRTVYP-EIDGVGTQV 3267 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAP--------FELSRDAPLRITVVR 112 + RP SQ L + E A F+++R+ PLR + Sbjct 3268 I----RPA---------SQVRVALEPVAIGADELPAALGELARWTFDVTREVPLRAELYE 3314 Query 113 TAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRP 160 + EHVL LV HHIA D S D+ AY+ +G AD R Sbjct 3315 LSPTEHVLALVVHHIAADGFSMGPLTRDIMVAYTARCVGSVPAWQPLPVQYADYALWQRE 3374 Query 161 --SAASGPDTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAAR 217 A PD+ A + YWR +A P+ L+LP S R A + A Sbjct 3375 VLGAEDDPDSVFAQQIAYWRDRLAGAPDQLDLPADRPRPAVASGRGATHRFTVSASIHRA 3434 Query 218 VATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAM 276 V AK T TP+MV AA L R + + D + PV RG + +D +G F NT+ + Sbjct 3435 VVAFAKRTNTTPFMVFHAALSVLAARLSGTSDISIGTPVAGRGESAIDDLVGMFVNTLVL 3494 Query 277 RLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREP 336 R SF L+ + R+ GAFAH + +R+V L P R + +V F+ Sbjct 3495 RTEVDGDRSFEALVESVRETDLGAFAHSDVPFERLVEVLAPARSQARNPLFQVMLAFQNL 3554 Query 337 DGGGFNPPGIECERYDLRSNITQ--LPLGFMVEFDRAG----VLVEAEHLVEILEPALAK 390 F PG+ D ++ + + M D AG + VE + ++ E A Sbjct 3555 GRTSFELPGVTVSEVDFDEVFSKFDIQVSVMESIDDAGTAGGLTVELTYATDLFEAATMA 3614 Query 391 QMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTT 450 + +L LA P + +AL+D + +R+ E TL + Q + Sbjct 3615 EFGTRLVRILSAVLADPSVAVGDVALLDAAERSRVVEDWNATGRVVDGTTLPESFEAQVS 3674 Query 451 RTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVV 510 RTPDATAVV EG+ TY R+ +LI +G+G E VAV + +S D +V V Sbjct 3675 RTPDATAVVCEGESLTYAQFAARVRRMARFLISEGVGPESLVAVAMGRSLDQLVALYAVT 3734 Query 511 KSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP--------VR--------ELAGYRSD 554 +G YVPVDP P R +IL + L+L T VR +++GY Sbjct 3735 VAGGAYVPVDPDQPARRNAYILETANPVLLLTTSREHEGLPAVRRTVHLDTVDVSGYSDA 3794 Query 555 DPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQ 614 T A+R PLRPDN AY+++TSG+TG PKGV V HR + W + EY + DR+L Sbjct 3795 PVTAAERPAPLRPDNAAYVVFTSGSTGRPKGVTVSHRSIVNQLAWMQAEYTLSAADRVLL 3854 Query 615 VASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFL 674 +FD S+ E+F L GA +V+ D L ++ D +T FVPS+L + Sbjct 3855 KTVFTFDASVWELFWPLQAGAAIVVAPRDAHRDPLALARVIGDRAVTVAQFVPSVLEATI 3914 Query 675 SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQG 734 +L RV GGE L G + + A +HN YGPTE + A+R + G + Sbjct 3915 DHLDADAATSLTRVFSGGEALTGALVSRLRRVAGASVHNLYGPTEATVQATRHEATGAE- 3973 Query 735 TRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF 794 + +VPIG P NT +LD+ L PVP GV GE+Y+ G +A GY R LTA+RFVA+PF Sbjct 3974 SGVVPIGTPVWNTRAFVLDERLNPVPVGVPGELYLAGVQLARGYAARTDLTADRFVANPF 4033 Query 795 -NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVV 853 + G RMYR+GDL RR DG +E++GR D QVK+RG RIEL ++ A+ P + +AVVV Sbjct 4034 SDSGERMYRTGDLVRRTRDGRLEYLGRTDFQVKLRGLRIELEEIETALLALPEITRAVVV 4093 Query 854 VSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPIT 913 V D LV YV A D D ++A +A +L YM+P +V LD P+ Sbjct 4094 VKD-----DQLVAYVV--------AGTHFDADTVKAALATSLASYMVPQVFVALDAFPLN 4140 Query 914 AHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLL 973 A GK+DR ALPEP+ + FRAP T T+ +A +F ++L DRVG DD FF LGG+SL+ Sbjct 4141 ASGKLDRKALPEPEFETKA-FRAPTTPTQEIVAGVFADVLDLDRVGLDDDFFALGGNSLV 4199 Query 974 ATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSS 1033 AT++V+ + A V VR +FE +TV +LA + L +RP LT + LS + Sbjct 4200 ATQVVSRLGAALDTQVPVRALFEASTVESLAARVQVLAGSGSRPALTSRVRPERIPLSLA 4259 Query 1034 QMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPH 1093 Q R WF RF+ +AVNNIP A L G D A A+ DV+ARHE LRTV+ ++ GV Sbjct 4260 QQRMWFLSRFEPESAVNNIPLAIRLSGGLDVEALRRAVRDVIARHESLRTVFPDVDGVGT 4319 Query 1094 QIIQPPAEVPVRC--AAGSDAAWL-RAELNNERGYVFDLETDWPIRAALLS-TPEQTVLS 1149 Q + P V + A D + R E G FDL D P+RAAL + ++ VL+ Sbjct 4320 QAVLPVERVTIELEPEAVPDGELIGRIESLATAG--FDLAADVPVRAALFRLSDDEHVLA 4377 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGA 1206 +VVHHIA D +S L D++TAY ARS G+ P+WAPL VQYADY++WQ +L DD Sbjct 4378 IVVHHIASDGFSMAPLARDVMTAYAARSAGEAPAWAPLAVQYADYTLWQREVLGSEDDSE 4437 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 ++ Q YW QL L + L D PRP + S G + F +G + + AV+R G Sbjct 4438 SVISRQVSYWTEQLADLPEQLDLPSDRPRPVVASNHGASYRFSIGPELHAAIDAVARARG 4497 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 VT FM++ A+AV+L + G D+ IG PVAGR EA LD +IG F+ +VLR D+ G Sbjct 4498 VTPFMVVHGALAVLLARLSGTSDIAIGTPVAGRGEAALDDVIGMFVGTLVLRTDVDGGQP 4557 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 E+L R R LAA+ H DLPF+++VE ++P+RS +R+PLF +++ + +D Sbjct 4558 FEELLARIRSTDLAAFEHADLPFERLVEILDPERSQARHPLFQVMLAFQN-------LDR 4610 Query 1387 GPDGDTTLRVLEPTFDAAQA--DLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVR 1444 L V FDAA A DL V Y + Y T+L++ A+ + FA VR Sbjct 4611 ASLELAGLHVSTVDFDAAVAKFDLQVTVEPVEAGYTVDLTYATDLFDEASMRVFAARFVR 4670 Query 1445 VVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 V++ P + +++++ + R +LD NA Sbjct 4671 VLDEVVTDPAVVVGDIDLLDDRERSLVLDEWNA 4703 Score = 829 bits (2142), Expect = 0.0, Method: Compositional matrix adjust. Identities = 586/1653 (36%), Positives = 831/1653 (51%), Gaps = 139/1653 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ +P A+ NI ++ R++G +D+ LR AV V RH LRT +P DGV Sbjct 4263 MWFLSRFEPESAVNNIPLAIRLSGGLDVEALRRAVRDVIARHESLRTVFP-DVDGVGTQA 4321 Query 61 VHADLRPGWTQYDLTDLSQRAQRL--RLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 V R +L + L R+E LA A F+L+ D P+R + R + DEH Sbjct 4322 VLPVER---VTIELEPEAVPDGELIGRIESLA----TAGFDLAADVPVRAALFRLSDDEH 4374 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGP 166 VL +V HHIA D S D+ AY+ G AD R S Sbjct 4375 VLAIVVHHIASDGFSMAPLARDVMTAYAARSAGEAPAWAPLAVQYADYTLWQREVLGSED 4434 Query 167 DTTEA---DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D+ ++YW +AD PE L+LP V S A + + A + +A+ Sbjct 4435 DSESVISRQVSYWTEQLADLPEQLDLPSDRPRPVVASNHGASYRFSIGPELHAAIDAVAR 4494 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 G TP+MV+ A L+ R + + D + PV RG A +D IG F T+ +R Sbjct 4495 ARGVTPFMVVHGALAVLLARLSGTSDIAIGTPVAGRGEAALDDVIGMFVGTLVLRTDVDG 4554 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 F ELL R AF H + +R+V L+P+R + +V F+ D Sbjct 4555 GQPFEELLARIRSTDLAAFEHADLPFERLVEILDPERSQARHPLFQVMLAFQNLDRASLE 4614 Query 343 PPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDN 402 G+ D + + + L VE AG V+ + ++ + A + F +LD Sbjct 4615 LAGLHVSTVDFDAAVAKFDLQVTVEPVEAGYTVDLTYATDLFDEASMRVFAARFVRVLDE 4674 Query 403 ALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEG 462 + P + + L+D+R+ + + + TLVDL + Q TRTPDATA+VYEG Sbjct 4675 VVTDPAVVVGDIDLLDDRERSLVLDEWNATDHPVTASTLVDLFDAQVTRTPDATALVYEG 4734 Query 463 QHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPS 522 + +Y + R LI +G+G + V + + +SPDL+V V+ +G YVP+DP Sbjct 4735 ESLSYAEFAARVRRTARLLIAEGVGPDSLVGLGVRRSPDLLVGMYAVLAAGGGYVPIDPD 4794 Query 523 YPQDRLDFILADCDAKLVLRTP--------------VRELAGYR-SDDP-TDADRIRPLR 566 P +R +IL + L+L T + EL R SD P TDA+R PLR Sbjct 4795 QPAERNAYILETANPVLLLSTSRDGADLPAAQRVVALDELDVSRFSDAPVTDAERRAPLR 4854 Query 567 PDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAE 626 P NTAY+I+TSG+TG PKGVAV H + W EY + D +LQ +FDVS+ E Sbjct 4855 PGNTAYVIFTSGSTGRPKGVAVGHTAIVNQIEWLCAEYALSADDVVLQKTPFTFDVSLWE 4914 Query 627 IFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQ 686 +FGTLA G R+VI P G D YL ++ + +TA FVPS+L F + +L+ Sbjct 4915 LFGTLAVGGRLVIATPDGHRDPAYLKRVIEAQAVTATSFVPSMLTAFTAELAAGDCDSLR 4974 Query 687 RVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKIN 746 V + GE P A +F A A LHN YGPTE ++A+ V G G VP+G P N Sbjct 4975 LVQVAGEAFPTSAAARFAAVNGAELHNLYGPTEFTVHATARPVAGTVGAS-VPMGSPVWN 5033 Query 747 TTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NPGSRMYRSGD 805 + ++LD L+PVP GV GE+Y+ G +A GY RA LTA+RFVA+PF G RMYR+GD Sbjct 5034 SRAYVLDGRLRPVPAGVAGELYLAGAQLARGYFGRADLTADRFVANPFAAAGERMYRTGD 5093 Query 806 LARRNAD----------GDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVS 855 L + G++E++GR D QVK+RG RIELG++ A+ P + Q+VV+V Sbjct 5094 LVKWTVGASEATGDLPAGELEYLGRTDFQVKLRGLRIELGEIETALLARPEITQSVVLVK 5153 Query 856 DLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAH 915 LV YV A G+D+D I+A +AA+L YM+P +VVLD P+ A Sbjct 5154 -----SDQLVAYVV--------ATGGLDVDGIKAELAASLASYMVPQTFVVLDSFPLNAS 5200 Query 916 GKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLAT 975 GK+DR ALPEP + FRAP T+T+ +A +F E+LG DRVG DD FF LGG+SL+AT Sbjct 5201 GKLDRKALPEP-VFETRAFRAPTTSTQEIVAGVFAEVLGVDRVGLDDDFFALGGNSLIAT 5259 Query 976 KLVAAVRNAFGVDVGVREIFEFATVTALAGHID-----TLDSDSARPRLTRVDHDGPVRL 1030 ++V+ + A V VRE+FE +TV ALA + T + +ARPR R+ L Sbjct 5260 QVVSRLSRALDTRVPVRELFEASTVEALAARLTQQAGGTRKALTARPRPERIP------L 5313 Query 1031 SSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGG 1090 S +Q R WF RFD + NIP A + G D A A+ DV RHE LRTV+ Sbjct 5314 SLAQQRMWFLNRFDTESTAYNIPLALRMSGNLDVAALDLALADVTERHESLRTVFPATDD 5373 Query 1091 VPHQIIQPPAE--VPVRC--AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQ 1145 P Q+I P A+ P+R A D L R FD+ +D PIR L T + Sbjct 5374 GPAQVILPAADARTPLRIVDVAPDDLPGRLRALAETR---FDVTSDVPIRVELYRTGADN 5430 Query 1146 TVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL--- 1202 VL +VVHHI+ D S L D++TAY AR+ G P W PL VQYADY++WQ +L Sbjct 5431 FVLGMVVHHISADGVSLAPLTRDVMTAYAARTAGHAPGWTPLAVQYADYALWQREILGHE 5490 Query 1203 DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVS 1262 D + Q YW L L + L D PRPA+ S G VEF + A L ++ Sbjct 5491 TDPESLAAQQLGYWSETLAELPDQLNLPTDHPRPAVQSFRGGLVEFEIDAPTHRALRDLA 5550 Query 1263 RDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLR 1322 R+ T FM + +A AV+L + G D+ +G P+AGR EA LD L+G F+N +V R + Sbjct 5551 REQNATLFMAVHSAFAVLLSRLSGSDDIAVGTPIAGRGEAELDALVGMFVNTLVFRTRVD 5610 Query 1323 GNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDH 1382 G + +++ R L A+AH D+PF+++VE +NP RS +R+PLF + Q+H Sbjct 5611 GARSFADLVSEVRDTDLEAFAHADVPFERLVEHLNPTRSTARHPLFQVGFSF-----QNH 5665 Query 1383 VIDTGPDGDTTLRVLEPTFDAAQADLSVNFF----ACGDEY---------RGHVIYRTEL 1429 DTG L + T +AA+ + V F D Y + + Y +L Sbjct 5666 --DTG-----ALELPGLTVEAAEIESGVAQFDLHMIVEDHYDDGGDPTGMKASMTYALDL 5718 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRIL----DRSNAGAGTARVY 1485 ++ +T + FA+ R++ A +P P+ +V+++ + R R+L D + A A V Sbjct 5719 FDESTVRSFAERFARLLAAVVVKPTLPVGDVDLLGLEERARLLVERNDTATATARATLVD 5778 Query 1486 LLDDALKPVPVGV-----VGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 L D +K P G+ V Y G A RLAR R +AD P S + + Sbjct 5779 LFDAQVKATPDGIALVSGAERVTYAGFDARVNRLAR------RLIAD--GVGPESLVALS 5830 Query 1541 GERGVWKADGQLELLAEIERLPTAQAAPVPAEP 1573 R V +LL + + A A VP +P Sbjct 5831 IRRSV-------DLLVGMYAVAKAGGAYVPVDP 5856 Score = 796 bits (2055), Expect = 0.0, Method: Compositional matrix adjust. Identities = 548/1540 (36%), Positives = 791/1540 (52%), Gaps = 106/1540 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ DP A N+ R+ GD+D+ L+ A+ V RH LRT +P DG Q Sbjct 2159 MWFLNRLDPRSATYNLAFGLRLRGDLDVVALQVALVDVLDRHESLRTVFPDSPDGPHQVV 2218 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V A +LT + L +++ A F+++ + P+R T+ R +HVL Sbjct 2219 VDAVR----VVPNLTPVHVGVDELHRAMVSFA--SAGFDVTTETPVRATLFRIDPFDHVL 2272 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAY-SRADLG-----------ADLGPEHRPSAASGPD- 167 +V HHI+ D S D+ +Y +R G AD R S D Sbjct 2273 AIVVHHISADGWSMGPLARDVMASYDARVRWGQPVWEALPVQYADYALWQRQILGSEDDE 2332 Query 168 --TTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 YW A + P+ L+LP S+R A+ +PAD + +A Sbjct 2333 DSIVAKQARYWSAHLDGLPDQLDLPTDRPRPARQSYRGAKIDFTVPADVHRALIAIAHER 2392 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAM 284 + +MV+ AA L+ R +DD + PV RG +D +G F NT+ +R +S Sbjct 2393 NASLFMVVHAALSVLLSRSAATDDVAIGTPVAGRGEQALDDLVGMFVNTLVLRTHVESGT 2452 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 F +LL+ RD+A GAFA+ I +R+V LNP R + +V F P Sbjct 2453 RFADLLSHARDVALGAFANSDIPFERLVEILNPARSTARHPLIQVMLSFENLGTTHLELP 2512 Query 345 GIECERYDLRSNITQLPLGFMVEFDRA------GVLVEAEHLVEILEPALAKQMLRHFGV 398 + ++ +L + + + L F G+ E + ++ + + + F Sbjct 2513 DLTIDKVELDAEVAKFDLQFTFRESIGEGGLADGMAGEFTYATDLFDASTVQAFADRFLR 2572 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKT-LVDLVNEQTTRTPDATA 457 +L +A PD + + L+ + A+L + D P T L DL+ P+A A Sbjct 2573 ILAAVVADPDTVVGDIDLLGAEEIAQL---TGPAGLDAPAPTPLPDLLAAAADSDPEALA 2629 Query 458 VVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV 517 +V + TY +L+E S RL L+ +G G ED +AV L +S + + V KSGA +V Sbjct 2630 LVAGVEELTYRELDERSTRLARLLVSRGAGPEDVIAVALTRSVESVTAVWAVAKSGAAFV 2689 Query 518 PVDPSYPQDRLDFILADCDAKLVLRTPVRE--------------------LAGYRSDDPT 557 PVDP+YP+DR+ +++D A L + T LA D + Sbjct 2690 PVDPNYPRDRVAHMVSDSGAVLGVTTSEHADALPDGLPWLVLDDAAVAAGLAEQSVDRLS 2749 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 +ADR+RPL PD+ AY+IYTSG+TG+PKGV V H +A + Y +D R L AS Sbjct 2750 NADRVRPLTPDHPAYVIYTSGSTGVPKGVVVTHTGLAAFAAEQVERYGIDSASRTLHFAS 2809 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLP 677 PSFD SI E+ GA MVI P + LT LL ++ P+ L Sbjct 2810 PSFDASILELLMAFGAGATMVIA-PTSIYGGQELTELLASRHVSHAFVTPAALASV---- 2864 Query 678 GVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRI 737 S L V +GGE ++ ++ AT + N YGPTE + ++ + P Sbjct 2865 DPSALDALGVVVVGGEACSADLVARW-ATGGRKMFNAYGPTEATVASNISDPLVPG--EP 2921 Query 738 VPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-P 796 V IGR ++LD L+PVP GV+GE+Y+ G +A GYH RAGLTAERFVA+PF P Sbjct 2922 VTIGRAIRGAATYVLDARLRPVPAGVVGELYLEGAGLARGYHERAGLTAERFVANPFGLP 2981 Query 797 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 856 GSR+YR+GD+ R AD +E+VGRAD+QVK+RGFRIELG++ A + V QAVVVV Sbjct 2982 GSRLYRTGDVVRTTADRVLEYVGRADDQVKLRGFRIELGEIEAVLHRLSDVAQAVVVVRH 3041 Query 857 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 916 + LV Y+ A G +D ++ V ALP YM+PAA VVLDE+PI+ G Sbjct 3042 -----QQLVAYLVAAPGA------SIDPAEVKDTVGRALPAYMVPAAVVVLDELPISGSG 3090 Query 917 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 976 K+DR ALPEP+ EFRAP+T E +A +F ELL RVG DD FF+LGG+SL+AT+ Sbjct 3091 KLDRKALPEPEFEV-REFRAPETPIEEIVAGVFAELLDTPRVGRDDDFFELGGNSLVATR 3149 Query 977 LVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMR 1036 +VA + + VRE+FE +TV ALA I+ RP + + + + LS +Q R Sbjct 3150 VVARIGEGLDTRIPVRELFEASTVQALAARIEQSVGSGRRPLVAKSRPER-IPLSYAQQR 3208 Query 1037 SWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQII 1096 WF RFD +A NNIP A L G D A AA+ DV+ RHE LRTVY EI GV Q+I Sbjct 3209 MWFLNRFDVSSAGNNIPVAVRLSGLLDRTALRAAVGDVIVRHESLRTVYPEIDGVGTQVI 3268 Query 1097 QPPAEVPVR---CAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLVV 1152 +P ++V V A G+D L A L + FD+ + P+RA L +P + VL+LVV Sbjct 3269 RPASQVRVALEPVAIGADE--LPAALGELARWTFDVTREVPLRAELYELSPTEHVLALVV 3326 Query 1153 HHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIV 1209 HHIA D +S G L D++ AY AR G P+W PLPVQYADY++WQ +L DD + Sbjct 3327 HHIAADGFSMGPLTRDIMVAYTARCVGSVPAWQPLPVQYADYALWQREVLGAEDDPDSVF 3386 Query 1210 GPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTE 1269 Q YW +L G + L D PRPA+ SG G F + A+I + A ++ T Sbjct 3387 AQQIAYWRDRLAGAPDQLDLPADRPRPAVASGRGATHRFTVSASIHRAVVAFAKRTNTTP 3446 Query 1270 FMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLRE 1329 FM+ AA++V+ + G D+ IG PVAGR E+ +D L+G F+N +VLR ++ G+ + Sbjct 3447 FMVFHAALSVLAARLSGTSDISIGTPVAGRGESAIDDLVGMFVNTLVLRTEVDGDRSFEA 3506 Query 1330 VLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE------QMPQDHV 1383 +++ R+ L A+AH D+PF+++VE + P RS +RNPLF +++ + ++P V Sbjct 3507 LVESVRETDLGAFAHSDVPFERLVEVLAPARSQARNPLFQVMLAFQNLGRTSFELPGVTV 3566 Query 1384 IDTGPDG-----DTTLRVLEPTFDAAQA-DLSVNFFACGDEYRGHVIYRTELYERATAQR 1437 + D D + V+E DA A L+V Y T+L+E AT Sbjct 3567 SEVDFDEVFSKFDIQVSVMESIDDAGTAGGLTVEL-----------TYATDLFEAATMAE 3615 Query 1438 FADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 F LVR++ A P + +V ++ A R R+++ NA Sbjct 3616 FGTRLVRILSAVLADPSVAVGDVALLDAAERSRVVEDWNA 3655 Score = 755 bits (1950), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/1537 (34%), Positives = 771/1537 (51%), Gaps = 106/1537 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + A+ N+ + R++G +D A V RH LRT YP DGVA+ Sbjct 1093 MWFLNRFDATTAVYNLPFAVRLSGAVDPQAFSAAFADVVERHESLRTVYP-EVDGVARQV 1151 Query 61 VHA------DLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTA 114 V DL P T D DL RL A R F +++ + P RI ++R + Sbjct 1152 VLPARDVVRDLEPVATAAD--DLEPTLLRL-----ASRGF----DVTSEPPFRIELLRLS 1200 Query 115 ADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD--------------------L 154 E+V+ +V HHIA D S+ DL AY+ GA L Sbjct 1201 DAEYVVAMVLHHIAADGSSFGPLARDLMIAYAARSEGAAPAWEPLPVQYADYAVWQHEML 1260 Query 155 GPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADT 214 G E P++ +G + YW +A P+ L+LP S A+ + A T Sbjct 1261 GSETDPNSIAG-----QQIAYWTEALAGLPDQLDLPADRPRPAVASNAGAKLRFDISAQT 1315 Query 215 AARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNT 273 AR+ +A+ G T +MV+ AA+ L+ R + + D V PV RG D IG F NT Sbjct 1316 HARLLDVAREHGATLFMVVHAAYAMLLARLSGTSDIAVGTPVAGRGDQALDGLIGMFVNT 1375 Query 274 VAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSF-- 331 + +R + ++F +L+ A + A+ + + + +V L P R + + Sbjct 1376 LVLRTQVDPDITFADLIDAVKTTDLEAYGNADVPFEWLVEALEPTRSPARHPLFQAMLSA 1435 Query 332 ---GFREPDGGGFNPPGIECE----RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEIL 384 G R+ G E + ++DL+ I++ GF A + E+ ++ Sbjct 1436 EVAGVRDLSFAGVRAAAAELDVPVSKFDLQLQISE---GFDESGAPASIGAVFEYATDLF 1492 Query 385 EPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDL 444 + + F +L+ ++ T+ + L+DE + R+ D P TL +L Sbjct 1493 DESTVATFAERFVRILNAIVSDTTVTVGDVCLLDETEQRRVVHEWNRTGHDLPAVTLPEL 1552 Query 445 VNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIV 504 + Q TP A AVV+ +TY + NRL L+ G+G E VAV +++SP+L+ Sbjct 1553 FDRQAAATPSAPAVVFATGSWTYEEFASRVNRLARHLVGLGVGPESVVAVAMERSPELLT 1612 Query 505 TALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP---------VR-------EL 548 V+ +G YVP+DP P +R IL VL T VR +L Sbjct 1613 AVYAVLAAGGAYVPIDPRQPAERNTHILGTAGPSCVLTTSGDDIDLPEDVRRVDVDTLDL 1672 Query 549 AGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDD 608 + TDA R PLRP+N AY+++TSG+TG PKGV + H V + + EY + Sbjct 1673 SALSPAPLTDAARRAPLRPENAAYVLFTSGSTGRPKGVTISHSAVVNQLLSMQDEYRLGA 1732 Query 609 TDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPS 668 D +L +FD S+ E+F L GAR+V+ P G D YL +L ++ IT + FVP+ Sbjct 1733 DDSVLFKTPVTFDASVWELFWPLESGARIVVAAPDGHRDPAYLARILAEQAITVVQFVPT 1792 Query 669 LLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFK 728 +L +L V GGEPL V + + DA +HN YGPTET + +R Sbjct 1793 VLDAVADHLERQGCVSLTHVFCGGEPLTTAVVSRVRSICDAAIHNLYGPTETAVQVTRRT 1852 Query 729 VVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAER 788 V G + + VPIG P N+ + +LD L PVP GV+GE+Y+ G +A GY R+ LT+ER Sbjct 1853 VAGTE-SAAVPIGAPVWNSQVRVLDSRLNPVPAGVVGELYVSGAQLARGYRGRSDLTSER 1911 Query 789 FVADPFNPGSRMYRSGDLARRNAD----GDIEFVGRADEQVKIRGFRIELGDVAAAIAVD 844 FVADP+ PG RMYR+GDL R D G++E+VGR+D QVK+RG RIELG+V A+ Sbjct 1912 FVADPWAPGERMYRTGDLVRWIVDADGAGELEYVGRSDFQVKLRGLRIELGEVETAVREH 1971 Query 845 PTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAY 904 +V QAVV + PR G LV YV +A P D +R ++ LP YM+P + Sbjct 1972 GSVSQAVVALHHDPRAGDQLVAYVVASAECAVPFDPA----NLREHLSLRLPSYMVPTMF 2027 Query 905 VVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSF 964 + +D +P T GKIDR ALP P + + FR P+T E +A + ++LG + VG DD F Sbjct 2028 LPIDALPRTTSGKIDRRALPVPVFEAKS-FRIPRTPVEEIVADVLADVLGVETVGLDDEF 2086 Query 965 FDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDH 1024 F LGG+SL+AT++VA + A V VR +FE +TV LA ++ R L + Sbjct 2087 FALGGNSLIATQVVARLGAALDTSVPVRVLFESSTVEQLAVRVEQHAGAGNRAPLVAQER 2146 Query 1025 DGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTV 1084 V LS +Q R WF R D +A N+ F L G D A A+ DV+ RHE LRTV Sbjct 2147 PDRVPLSLAQQRMWFLNRLDPRSATYNLAFGLRLRGDLDVVALQVALVDVLDRHESLRTV 2206 Query 1085 YREIGGVPHQIIQP-----PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAAL 1139 + + PHQ++ P PV G D L + + FD+ T+ P+RA L Sbjct 2207 FPDSPDGPHQVVVDAVRVVPNLTPVHV--GVDE--LHRAMVSFASAGFDVTTETPVRATL 2262 Query 1140 LST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQ 1198 P VL++VVHHI+ D WS G L D++ +Y AR +P W LPVQYADY++WQ Sbjct 2263 FRIDPFDHVLAIVVHHISADGWSMGPLARDVMASYDARVRWGQPVWEALPVQYADYALWQ 2322 Query 1199 SALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIR 1255 +L DD IV Q YW L GL + L D PRPA S G ++F + A + Sbjct 2323 RQILGSEDDEDSIVAKQARYWSAHLDGLPDQLDLPTDRPRPARQSYRGAKIDFTVPADVH 2382 Query 1256 DKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIV 1315 L A++ + + FM++ AA++V+L ++ DV IG PVAGR E LD L+G F+N + Sbjct 2383 RALIAIAHERNASLFMVVHAALSVLLSRSAATDDVAIGTPVAGRGEQALDDLVGMFVNTL 2442 Query 1316 VLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVR 1375 VLR + ++L R +AL A+A+ D+PF+++VE +NP RS +R+PL +++ Sbjct 2443 VLRTHVESGTRFADLLSHARDVALGAFANSDIPFERLVEILNPARSTARHPLIQVMLSF- 2501 Query 1376 EQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFF------ACGDEYRGHVIYRTEL 1429 E + H+ D T+ +E + A+ DL F D G Y T+L Sbjct 2502 ENLGTTHL----ELPDLTIDKVELDAEVAKFDLQFTFRESIGEGGLADGMAGEFTYATDL 2557 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQ 1466 ++ +T Q FAD +R++ A PD + +++++ A+ Sbjct 2558 FDASTVQAFADRFLRILAAVVADPDTVVGDIDLLGAE 2594 Score = 690 bits (1781), Expect = 0.0, Method: Compositional matrix adjust. Identities = 428/1073 (40%), Positives = 588/1073 (55%), Gaps = 48/1073 (4%) Query 439 KTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDK 498 + L + +EQ RTP ATA+V+EG+ TY +L+ +N L LI G+G E V + + + Sbjct 479 RNLAEAFDEQVARTPGATALVFEGETLTYAELDARANALARTLIGIGVGPESLVGLSIRR 538 Query 499 SPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP-------------- 544 S DLIV +VKSG +VP+DP +P DR +IL VL T Sbjct 539 SLDLIVGLYAIVKSGGAWVPIDPDHPADRTAYILESAGPACVLTTARDAVDLPAGIVSIE 598 Query 545 --VRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKG 602 +L + TDADR+ PLRP+NTAY+IYTSG+TG PKGVAV H + W Sbjct 599 IDTIDLPALDTRTVTDADRLAPLRPENTAYVIYTSGSTGRPKGVAVSHAAIDNQLEWMLH 658 Query 603 EYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITA 662 EY + ++D LQ + +FDVS+ F L GA MVI P G D Y+ + + +T Sbjct 659 EYPMTESDAYLQKTATTFDVSLWGFFMPLRVGASMVIATPDGHRDPVYVANKIAEHSVTV 718 Query 663 MHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVI 722 FVPS+L +F++ +L+ + GE LP E A F A LHN YGPTE + Sbjct 719 TDFVPSMLTVFVANAPAGSCDSLRDCFVIGEALPPETAADFRELCGAGLHNLYGPTEAAV 778 Query 723 NASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRA 782 + + ++ GPQ T VPIG + NT ++LD L+P P G GE+Y+ G +A GY R Sbjct 779 SVTYYE-SGPQDTATVPIGLAEWNTRAYVLDHRLRPAPIGQPGELYLAGDQLARGYVGRP 837 Query 783 GLTAERFVADPFN-------PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +T++RFVA+PF G RMYR+GDL R ADG+++++GR D QVK RG RIELG Sbjct 838 DITSDRFVANPFGGLDGVGRAGERMYRTGDLVRWRADGNLDYIGRTDFQVKFRGQRIELG 897 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++ + V Q VV+V G LV YV PA G V DL R +L Sbjct 898 EIETVLLAHEDVSQTVVLVVSTAT-GDQLVAYVVPAPGR---TLVPADLAEFAGR---SL 950 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P YM+PA+ VLD P+ GK+DR ALPEP S+ EFRAP++ E+ +A ++ E+LG Sbjct 951 PAYMVPASVTVLDAFPLNTSGKLDRKALPEPTFLSNKEFRAPRSDAEKTVAAVYAEVLGI 1010 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI-DTLDSDS 1014 +RVG DD FF+LGG+SL+AT++V V A V +GVRE+FE +TV ALA DT + Sbjct 1011 ERVGLDDDFFELGGNSLVATQVVTRVGAALDVRLGVRELFEASTVAALAARAGDTAQRGT 1070 Query 1015 ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDV 1074 P L V + LS +Q R WF RFD AV N+PFA L G D AF+AA DV Sbjct 1071 GVPALGSVARPASIPLSLAQQRMWFLNRFDATTAVYNLPFAVRLSGAVDPQAFSAAFADV 1130 Query 1075 VARHEILRTVYREIGGVPHQIIQPPAEV-----PVRCAAGSDAAWLRAELNNERGYVFDL 1129 V RHE LRTVY E+ GV Q++ P +V PV AA L L FD+ Sbjct 1131 VERHESLRTVYPEVDGVARQVVLPARDVVRDLEPVATAADD----LEPTLLRLASRGFDV 1186 Query 1130 ETDWPIRAALLSTPE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLP 1188 ++ P R LL + + V+++V+HHIA D S G L DL+ AY ARS G P+W PLP Sbjct 1187 TSEPPFRIELLRLSDAEYVVAMVLHHIAADGSSFGPLARDLMIAYAARSEGAAPAWEPLP 1246 Query 1189 VQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 VQYADY+VWQ +L D I G Q YW L GL + L D PRPA+ S AG Sbjct 1247 VQYADYAVWQHEMLGSETDPNSIAGQQIAYWTEALAGLPDQLDLPADRPRPAVASNAGAK 1306 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 + F + A +L V+R+ G T FM++ AA A++L + G D+ +G PVAGR + LD Sbjct 1307 LRFDISAQTHARLLDVAREHGATLFMVVHAAYAMLLARLSGTSDIAVGTPVAGRGDQALD 1366 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 LIG F+N +VLR + + T +++ + L AY + D+PF+ +VEA+ P RS +R+ Sbjct 1367 GLIGMFVNTLVLRTQVDPDITFADLIDAVKTTDLEAYGNADVPFEWLVEALEPTRSPARH 1426 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYR-GHVI 1424 PLF ++ +D L V FD Q +S F G G V Sbjct 1427 PLFQAMLSAEVAGVRDLSFAGVRAAAAELDVPVSKFD-LQLQISEGFDESGAPASIGAVF 1485 Query 1425 -YRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Y T+L++ +T FA+ VR++ A + +V ++ +RR++ N Sbjct 1486 EYATDLFDESTVATFAERFVRILNAIVSDTTVTVGDVCLLDETEQRRVVHEWN 1538 Score = 62.4 bits (150), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 83/265 (32%), Positives = 108/265 (41%), Gaps = 99/265 (37%) Query 1472 LDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAA 1531 + R+ GA T Y+LD L+PVP GVVG++Y G R TA RFVA+PF Sbjct 2924 IGRAIRGAAT---YVLDARLRPVPAGVVGELYLEGAGLARGYHERAGLTAERFVANPFGL 2980 Query 1532 QPGSRLYRNGE----------RGVWKADGQLEL------LAEIE----RLP-TAQAAPV- 1569 PGSRLYR G+ V +AD Q++L L EIE RL AQA V Sbjct 2981 -PGSRLYRTGDVVRTTADRVLEYVGRADDQVKLRGFRIELGEIEAVLHRLSDVAQAVVVV 3039 Query 1570 ------------------PAEPADTETERAL-------AAILADVLEVGEVGRYD----- 1599 PAE DT RAL A ++ D L + G+ D Sbjct 3040 RHQQLVAYLVAAPGASIDPAEVKDT-VGRALPAYMVPAAVVVLDELPISGSGKLDRKALP 3098 Query 1600 -------------------------------------DFFNLGGDSILATQVAARARDG- 1621 DFF LGG+S++AT+V AR +G Sbjct 3099 EPEFEVREFRAPETPIEEIVAGVFAELLDTPRVGRDDDFFELGGNSLVATRVVARIGEGL 3158 Query 1622 --GIPLTARMVFEHPVLCELAAAVD 1644 IP+ R +FE + LAA ++ Sbjct 3159 DTRIPV--RELFEASTVQALAARIE 3181 Score = 60.8 bits (146), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 30/78 (39%), Positives = 44/78 (57%), Gaps = 5/78 (6%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFA-----AQPGSRL 1537 R Y+LD L+P P+G G++Y G + RP T+ RFVA+PF + G R+ Sbjct 803 RAYVLDHRLRPAPIGQPGELYLAGDQLARGYVGRPDITSDRFVANPFGGLDGVGRAGERM 862 Query 1538 YRNGERGVWKADGQLELL 1555 YR G+ W+ADG L+ + Sbjct 863 YRTGDLVRWRADGNLDYI 880 Score = 60.1 bits (144), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 33/73 (46%), Positives = 41/73 (57%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RVY+LD L PVP GV G++Y G R TA RFVADP+A G R+YR G+ Sbjct 6097 RVYVLDSRLNPVPAGVTGELYLAGVQLARGYHGRADLTADRFVADPWAT--GERMYRTGD 6154 Query 1543 RGVWKADGQLELL 1555 W A +LE + Sbjct 6155 VVRWNASDELEYV 6167 Score = 57.8 bits (138), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/73 (46%), Positives = 43/73 (59%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R ++LD+ L PVPVGV G++Y G AR TA RFVA+PF + G R+YR G+ Sbjct 3987 RAFVLDERLNPVPVGVPGELYLAGVQLARGYAARTDLTADRFVANPF-SDSGERMYRTGD 4045 Query 1543 RGVWKADGQLELL 1555 DG+LE L Sbjct 4046 LVRRTRDGRLEYL 4058 Score = 57.4 bits (137), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/76 (45%), Positives = 44/76 (58%), Gaps = 4/76 (5%) Query 1481 TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 ++V +LD L PVP GVVG++Y G R T+ RFVADP+A PG R+YR Sbjct 1869 NSQVRVLDSRLNPVPAGVVGELYVSGAQLARGYRGRSDLTSERFVADPWA--PGERMYRT 1926 Query 1541 GE--RGVWKADGQLEL 1554 G+ R + ADG EL Sbjct 1927 GDLVRWIVDADGAGEL 1942 Score = 53.1 bits (126), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 38/89 (43%), Positives = 52/89 (59%), Gaps = 11/89 (12%) Query 1565 QAAPVPAEPAD------TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR- 1617 +A PVP A T E +A +LADVL V VG D+FF LGG+S++ATQV AR Sbjct 2044 RALPVPVFEAKSFRIPRTPVEEIVADVLADVLGVETVGLDDEFFALGGNSLIATQVVARL 2103 Query 1618 --ARDGGIPLTARMVFEHPVLCELAAAVD 1644 A D +P+ R++FE + +LA V+ Sbjct 2104 GAALDTSVPV--RVLFESSTVEQLAVRVE 2130 Score = 52.8 bits (125), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/98 (40%), Positives = 53/98 (55%), Gaps = 12/98 (12%) Query 1574 ADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMV 1630 A T E +A ADVL + VG DDFF LGG+S++ATQ+ AR A D +P+ R+V Sbjct 6277 ATTPIEEIVAGAFADVLGIERVGLDDDFFELGGNSLVATQLVARLGAALDTQVPV--RVV 6334 Query 1631 FEHPVLCELAAAVD------AKPHVEAEPDDKHHAPMS 1662 FE + +A AV +P + A P H P+S Sbjct 6335 FEDSTVAGVAGAVTPLVGQGGRPALTARPRPP-HVPLS 6371 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/71 (46%), Positives = 45/71 (64%), Gaps = 5/71 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFE 1632 T T+ +A + ADVL++ VG DDFF LGG+S++ATQV +R A D +P+ R +FE Sbjct 4165 TPTQEIVAGVFADVLDLDRVGLDDDFFALGGNSLVATQVVSRLGAALDTQVPV--RALFE 4222 Query 1633 HPVLCELAAAV 1643 + LAA V Sbjct 4223 ASTVESLAARV 4233 Score = 49.7 bits (117), Expect = 0.005, Method: Compositional matrix adjust. Identities = 116/473 (25%), Positives = 175/473 (37%), Gaps = 62/473 (13%) Query 1027 PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR 1086 P LS +Q+ WF D P+ NI L G D A Sbjct 29 PFPLSQAQLGMWFAQHVD-PSVPANIAQYVELRGELDIARLHRASARAAGETGSGYVRLL 87 Query 1087 EIGGVPHQIIQP-----PAEVPVRCAAGSDAA---WLRAELNNERGYVFDLETDWPIRAA 1138 E+ P Q++ P V +R AA W+RA+ + DL D + AA Sbjct 88 EVDAEPRQLVDTTLDDTPEYVDLRSEPDPRAAALAWMRADYSAP----VDLLRDRLVVAA 143 Query 1139 LLSTPEQTVLSLV-VHHIAGDHWSAGVLFTDLLTAYRARSTGQRPS---WAPLPVQY-AD 1193 +L + HH+ D + A + Y A G PS +PL Y AD Sbjct 144 VLHVEDGLYYWYNRAHHVVLDGFGATTFVNRVAELYSAEVDGVEPSPNVASPLEKVYDAD 203 Query 1194 YSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAA 1253 + S RDYW+ ++ G+ T L PA LS D+ G A Sbjct 204 RTYRSSTRFTS-------DRDYWLERVAGVEEPTSLAGRAAPPAPLSRI-DSAALSDGTA 255 Query 1254 IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFIN 1313 R + A T + AA A L + G DV + PV R+ A L + G N Sbjct 256 AR--MDAFLEREDTTVATAVIAAFAAYLAQMTGREDVVLSLPVTARTNAVLRRSGGMTSN 313 Query 1314 IVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQV---VEAVNPQRSLSRNPLFDI 1370 +V LR + + T+ ++L A HQ + + V Q S P +I Sbjct 314 VVPLRLTVSADTTVSQLLGLVATEVSGALRHQRYRHEDIRRDVTGAAGQASFF-GPWVNI 372 Query 1371 VVHVRE-----QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIY 1425 ++ E + + H++ TG ++E DL VN + HV + Sbjct 373 MMFHTELRFGDTVGEQHILSTG--------LIE--------DLGVNVYQGIAGSTTHVDF 416 Query 1426 RT--ELY----ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRIL 1472 + LY R +RF ++L R V A + +QP+ E+ + + RR +L Sbjct 417 ESNPNLYGDDEARRNHERFVEFLDRYVAAGS---EQPVWELPLGTDVERRTVL 466 Score = 49.7 bits (117), Expect = 0.005, Method: Compositional matrix adjust. Identities = 85/330 (26%), Positives = 131/330 (40%), Gaps = 25/330 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF Q DPS NI + G++D+ARL A AR + Y + A+P Sbjct 39 MWFAQHVDPSVP-ANIAQYVELRGELDIARLH---RASARAAGETGSGYVRLLEVDAEPR 94 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 D T + S+ R + ++ AP +L RD + V+ + Sbjct 95 QLVDTTLDDTPEYVDLRSEPDPRAAALAWMRADYSAPVDLLRDRLVVAAVLHVEDGLYYW 154 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT----------- 169 AHH+ D F + + YS A++ G E P+ AS + Sbjct 155 YNRAHHVVLDGFGATTFVNRVAELYS-AEVD---GVEPSPNVASPLEKVYDADRTYRSST 210 Query 170 --EADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGC 227 +D +YW +A EP L G A P S + A L TAAR+ + Sbjct 211 RFTSDRDYWLERVAGVEEPTSLAGRAAPPAPLSRIDSAA---LSDGTAARMDAFLEREDT 267 Query 228 TPYMVLLAAFGALVHRYTHSDDFLVAAPVLNR-GAGTEDAIGYFGNTVAMRLRPQSAMSF 286 T ++AAF A + + T +D +++ PV R A + G N V +RL + + Sbjct 268 TVATAVIAAFAAYLAQMTGREDVVLSLPVTARTNAVLRRSGGMTSNVVPLRLTVSADTTV 327 Query 287 RELLTATRDIASGAFAHQRINLDRVVRELN 316 +LL SGA HQR + + R++ Sbjct 328 SQLLGLVATEVSGALRHQRYRHEDIRRDVT 357 Score = 49.3 bits (116), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/69 (45%), Positives = 43/69 (63%), Gaps = 5/69 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVA---ARARDGGIPLTARMVFE 1632 T T+ +A + A+VL V VG DDFF LGG+S++ATQV +RA D +P+ R +FE Sbjct 5223 TSTQEIVAGVFAEVLGVDRVGLDDDFFALGGNSLIATQVVSRLSRALDTRVPV--RELFE 5280 Query 1633 HPVLCELAA 1641 + LAA Sbjct 5281 ASTVEALAA 5289 Score = 49.3 bits (116), Expect = 0.007, Method: Compositional matrix adjust. Identities = 28/67 (42%), Positives = 41/67 (62%), Gaps = 1/67 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 ++ E+ +AA+ A+VL + VG DDFF LGG+S++ATQV R + L R +FE Sbjct 994 SDAEKTVAAVYAEVLGIERVGLDDDFFELGGNSLVATQVVTRVGAALDVRLGVRELFEAS 1053 Query 1635 VLCELAA 1641 + LAA Sbjct 1054 TVAALAA 1060 >gi|312140928|ref|YP_004008264.1| non-ribosomal peptide synthetase [Rhodococcus equi 103S] gi|311890267|emb|CBH49585.1| putative non-ribosomal peptide synthetase [Rhodococcus equi 103S] Length=6919 Score = 855 bits (2210), Expect = 0.0, Method: Compositional matrix adjust. Identities = 557/1529 (37%), Positives = 794/1529 (52%), Gaps = 86/1529 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D NI ++ R++G++D+ L A+ V RH LRT +P DDG AQ Sbjct 5321 MWFLNRFDTESTAYNIPLALRMSGNLDMEALDLALADVTERHESLRTVFPATDDGPAQVI 5380 Query 61 V-HADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 + AD R T + D++ RL LA+ F +++ D P+R+ + RT AD+ V Sbjct 5381 LPAADAR---TPLRVVDVAPDDLPGRLRALAETRF----DVTSDVPIRVELYRTGADDFV 5433 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------AD--------LGPEHR 159 L +V HHI+ D S D+ AY+ G AD LG E Sbjct 5434 LGMVVHHISADGVSLAPLTRDVMTAYAARTAGHAPGWTPLAVQYADYALWQREILGDETD 5493 Query 160 PSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVA 219 P + + L YW +A+ P+ L LP S+R + A T + Sbjct 5494 PESLAA-----QQLGYWSETLAELPDQLNLPTDHPRPAVQSFRGGLVEFEIDAPTHRALR 5548 Query 220 TMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNTVAMRL 278 +A+ T +M + +AF L+ R + SDD V P+ RG DA +G F NT+ R Sbjct 5549 DLAREQNATLFMAVHSAFAVLLSRLSGSDDIAVGTPIAGRGEAELDALVGMFVNTLVFRT 5608 Query 279 RPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDG 338 R A SF +L++ RD AFAH + +R+V LNP R + +V F F+ D Sbjct 5609 RVDGARSFADLVSEVRDTDLEAFAHADVPFERLVEHLNPTRSTARHPLFQVGFSFQNHDT 5668 Query 339 GGFNPPGIECERYDLRSNITQLPLGFMVE------FDRAGVLVEAEHLVEILEPALAKQM 392 G PG+ E ++ S + Q L +VE D G+ + +++ + + + Sbjct 5669 GALELPGLTVEAAEIESGVAQFDLHMIVEDHYDDGGDPTGMKASMTYALDLFDESTVRSF 5728 Query 393 LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT 452 F LL + P + + L+ + ARL T TLVDL + Q T Sbjct 5729 AERFARLLAAVVVKPTLPVGDVDLLGLEERARLLVERNDTATATERATLVDLFDAQVKAT 5788 Query 453 PDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKS 512 PD A+V + TY + + NRL LI G+G E VA+ + +S DL+V V K+ Sbjct 5789 PDGIALVSGAERVTYAEFDARVNRLARRLIADGVGPESLVALSIRRSVDLLVGMYAVAKA 5848 Query 513 GAVYVPVDPSYPQDRLDFILADCDAKLVLRT----------PVRE-----LAGYRSDDPT 557 G YVPVDP P DR +IL VL T PV E L + + Sbjct 5849 GGAYVPVDPDQPADRTGYILDAARPVCVLTTSRDGAAVASWPVLEIDTVDLDAFAATPVV 5908 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 DADR+RPL NTAY+I+TSG+TG PKGVAVPH + +W EY +D +D L + Sbjct 5909 DADRLRPLDSRNTAYVIFTSGSTGRPKGVAVPHGAIVNQLLWMHDEYGLDASDAALLKTA 5968 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLP 677 +FD+S+ E + T+ G R+VI P G D GYL +LRDE +T +H VPS+L + + Sbjct 5969 ATFDLSVWEFWSTITSGGRLVIASPDGHRDPGYLLGVLRDEEVTTLHVVPSMLSMLTTTA 6028 Query 678 GVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRI 737 G + +L+R+ GE LP A F A A+LHN YGPTE ++ + +V T + Sbjct 6029 GGTLPPSLRRIFAIGEALPAATAQAFRADNTAVLHNLYGPTEAAVSVTHHEVTDAD-TVV 6087 Query 738 VPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPG 797 VPIG P+ NT +++LD L PVP GV GE+Y+ G +A GYH RA LTA+RFVADP+ G Sbjct 6088 VPIGVPEWNTRVYVLDSRLNPVPAGVTGELYLAGVQLARGYHGRADLTADRFVADPWATG 6147 Query 798 SRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDL 857 RMYR+GD+ R NA ++E+V RAD QVK+RGFRIELG++ A + + +A V Sbjct 6148 ERMYRTGDVVRWNASDELEYVERADFQVKVRGFRIELGEIEAGLRELSGIREAAVTAHTD 6207 Query 858 PRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGK 917 G LV Y+ AD +D + +A LP YM+P+AYVVLD +P+ A+GK Sbjct 6208 AHTGTRLVAYLV--------ADADIDTATVNDALARTLPSYMVPSAYVVLDALPLNANGK 6259 Query 918 IDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKL 977 +DR LPEP + +FRA T E +A F ++LG +RVG DD FF+LGG+SL+AT+L Sbjct 6260 LDRKGLPEP-VFEARDFRAATTPIEEIVAGAFADVLGIERVGLDDDFFELGGNSLVATQL 6318 Query 978 VAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRS 1037 VA + A V VR +FE +TV +AG + L RP LT V LS +Q R Sbjct 6319 VARLGAALDTQVPVRVVFEDSTVAGVAGAVTPLVGQGGRPALTARPRPPHVPLSLAQQRM 6378 Query 1038 WFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQ 1097 W + D +A NIP A L G D A+A+ DV+ARHE+L T Y + P Q++ Sbjct 6379 WTLNQVDTASAAYNIPVAVRLSGALDAGVLASAVADVIARHEVLHTTYPDTADGPAQVLV 6438 Query 1098 P-PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPE-QTVLSLVVHHI 1155 P VP A + L G FD+ + P+RAAL + + + VL+ V HHI Sbjct 6439 PLDRAVPRLQPIAVSEADVTDRLIEFLGRGFDVTAEVPVRAALFAVGQTEHVLAFVAHHI 6498 Query 1156 AGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGA---GIVGPQ 1212 A D +S G L D++ AY AR G P W PL VQYADY++WQ +L D + V Q Sbjct 6499 AADGFSMGPLIRDVVLAYVARVDGGVPQWEPLGVQYADYTLWQREVLGDESDPDSAVARQ 6558 Query 1213 RDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFML 1272 YW+ +L G + L D PRPA S AG AV F + A + ++ +R+ G T FM+ Sbjct 6559 IAYWVHELKGAPELSALPTDRPRPARPSLAGAAVPFAVDADLAARVEKTAREQGATTFMV 6618 Query 1273 LQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQ 1332 AA+A++L + GG D+ IG PVAGR +A LD LIG F+ + LR + + + ++L Sbjct 6619 FHAALAILLSRLGGSNDITIGTPVAGRGDAALDDLIGMFVGTLALRTRVEPSASFADLLA 6678 Query 1333 RTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDT 1392 R LAA+A+ D+PF+QVVEA +R+ S +PLF +++ + + TG Sbjct 6679 HARTQDLAAFANADVPFEQVVEAAGVRRASSHSPLFQVMLTFQN-------MQTGTFALP 6731 Query 1393 TLRV--LEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYERATAQRFADWLVR 1444 L V L+ D ++ D+ V D+ G Y TEL++R T + FAD VR Sbjct 6732 GLEVSALDLGADQSKFDVQVTAVEQFDQSGALTGIDGSFTYATELFDRETVEVFADRFVR 6791 Query 1445 VVEAFADRPDQPLREVEMVSAQARRRILD 1473 +++A + P LR ++ V+ A R L+ Sbjct 6792 ILDAVTENPSVVLRAID-VTTDAERAALE 6819 Score = 835 bits (2156), Expect = 0.0, Method: Compositional matrix adjust. Identities = 559/1533 (37%), Positives = 782/1533 (52%), Gaps = 94/1533 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D S A NI V+ R++G +D LR AV V RH LRT YP DGV Sbjct 3210 MWFLNRFDVSSAGNNIPVAVRLSGLLDRTALRAAVGDVIVRHESLRTVYP-EIDGVGTQV 3268 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAP--------FELSRDAPLRITVVR 112 + RP SQ L + E A F+++R+ PLR + Sbjct 3269 I----RPA---------SQVRVALEPVAIGADELPAALGELARWTFDVTREVPLRAELYE 3315 Query 113 TAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRP 160 + EHVL LV HHIA D S D+ AY+ +G AD R Sbjct 3316 LSPTEHVLALVVHHIAADGFSMGPLTRDIMVAYTARCVGSVPAWQPLPVQYADYALWQRE 3375 Query 161 --SAASGPDTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAAR 217 A PD+ A + YWR +A P+ L+LP S R A + A Sbjct 3376 VLGAEDDPDSVFAQQIAYWRDRLAGAPDQLDLPADRPRPAVASGRGATHRFTVSASIHRA 3435 Query 218 VATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAM 276 V AK T TP+MV AA L R + + D + PV RG + +D +G F NT+ + Sbjct 3436 VVAFAKRTNTTPFMVFHAALSVLAARLSGTSDISIGTPVAGRGESAIDDLVGMFVNTLVL 3495 Query 277 RLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREP 336 R SF L+ + R+ GAFAH + +R+V L P R + +V F+ Sbjct 3496 RTEVDGDRSFEALVESVRETDLGAFAHSDVPFERLVEVLAPARSQARNPLFQVMLAFQNL 3555 Query 337 DGGGFNPPGIECERYDLRSNITQ--LPLGFMVEFDRAG----VLVEAEHLVEILEPALAK 390 F PG+ D ++ + + M D AG + VE + ++ E A Sbjct 3556 GRTSFELPGVTVSEVDFDEVFSKFDIQVSVMESIDDAGTAGGLTVELTYATDLFEAATMA 3615 Query 391 QMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTT 450 + +L LA P + +AL+D + +R+ E TL + Q + Sbjct 3616 EFGTRLVRILSAVLADPSVAVGDVALLDAAERSRVVEDWNATGRVVDGTTLPESFEAQVS 3675 Query 451 RTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVV 510 RTPDATAVV EG+ TY + R+ +LI +G+G E VAV + +S D +V V Sbjct 3676 RTPDATAVVCEGESLTYAEFTARVRRVARFLISEGVGPESLVAVAMGRSLDQLVALYAVT 3735 Query 511 KSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP--------VR--------ELAGYRSD 554 +G YVPVDP P R +IL + L+L T VR +++GY Sbjct 3736 VAGGAYVPVDPDQPARRNAYILETANPVLLLTTSREHEGLPAVRRTVHLDTVDVSGYSDA 3795 Query 555 DPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQ 614 T A+R PLRPDN AY+++TSG+TG PKGV V HR + W + EY + DR+L Sbjct 3796 PVTAAERPAPLRPDNAAYVVFTSGSTGRPKGVTVSHRSIVNQLAWMQAEYTLSAADRVLL 3855 Query 615 VASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFL 674 +FD S+ E+F L GA +V+ D L ++ D +T FVPS+L + Sbjct 3856 KTVFTFDASVWELFWPLQAGAAIVVAPRDAHRDPLALARIIGDRAVTVAQFVPSVLEATI 3915 Query 675 SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQG 734 +L RV GGE L G + + A +HN YGPTE + A+R + G + Sbjct 3916 DHLDADAATSLTRVFSGGEALTGALVSRLRRVAGASVHNLYGPTEATVQATRHEATGAE- 3974 Query 735 TRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF 794 + +VPIG P NT +LD+ L PVP GV GE+Y+ G +A GY R LTA+RFVA+PF Sbjct 3975 SGVVPIGTPVWNTRAFVLDERLNPVPVGVPGELYLAGVQLARGYAARTDLTADRFVANPF 4034 Query 795 -NPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVV 853 + G RMYR+GDL RR DG +E++GR D QVK+RG RIEL ++ A+ P + +AVVV Sbjct 4035 SDSGERMYRTGDLVRRTRDGRLEYLGRTDFQVKLRGLRIELEEIETALLALPEITRAVVV 4094 Query 854 VSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPIT 913 V D LV YV A D D ++A +A +L YM+P +V LD P+ Sbjct 4095 VKD-----DQLVAYVV--------AGTHFDADTVKAALATSLASYMVPQVFVALDAFPLN 4141 Query 914 AHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLL 973 A GK+DR ALPEP+ + FRAP T T+ +A +F ++L DRVG DD FF LGG+SL+ Sbjct 4142 ASGKLDRKALPEPEFETKA-FRAPTTPTQEIVAGVFADVLDLDRVGLDDDFFALGGNSLV 4200 Query 974 ATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSS 1033 AT++V+ + A V VR +FE +TV +LA + L +RP LT + LS + Sbjct 4201 ATQVVSRLGAALDTQVPVRALFEASTVESLAARVQVLAGSGSRPALTSRVRPERIPLSLA 4260 Query 1034 QMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPH 1093 Q R WF RF+ +AVNNIP A L G D A A+ DV+ARHE LRTV+ ++ GV Sbjct 4261 QQRMWFLSRFEPESAVNNIPLAIRLSGGLDVEALRRAVRDVIARHESLRTVFPDVDGVGT 4320 Query 1094 QIIQPPAEVPVRC--AAGSDAAWL-RAELNNERGYVFDLETDWPIRAALLS-TPEQTVLS 1149 Q + P V + A D + R E G FDL D P+RAAL ++ VL+ Sbjct 4321 QAVLPVERVTIELEPEAVPDGELIGRIESLATAG--FDLAADVPVRAALFRLADDEHVLA 4378 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGA 1206 +VVHHIA D +S L D++TAY ARS G+ P+WAPL VQYADY++WQ +L DD Sbjct 4379 IVVHHIASDGFSMAPLARDVMTAYAARSAGEAPAWAPLAVQYADYTLWQREVLGSEDDSE 4438 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 ++ Q YW QL L + L D PRP + S G + F +G + + AV+R G Sbjct 4439 SVISRQVSYWTEQLADLPEQLDLPSDRPRPVVASNHGASYRFSIGPELHGAIDAVARARG 4498 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 VT FM++ A+AV+L + G D+ IG PVAGR EA LD +IG F+ +VLR D+ G Sbjct 4499 VTPFMVVHGALAVLLARLSGTSDIAIGTPVAGRGEAALDDVIGMFVGTLVLRTDVDGGQP 4558 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 E+L R R LAA+ H DLPF+++VE ++P+RS +R+PLF +++ + +D Sbjct 4559 FEELLARIRSTDLAAFEHADLPFERLVEILDPERSQARHPLFQVMLAFQN-------LDR 4611 Query 1387 GPDGDTTLRVLEPTFDAAQA--DLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVR 1444 L V FDAA A DL V Y + Y T+L++ A+ + FA VR Sbjct 4612 ASLELAGLHVSTVDFDAAVAKFDLQVTVEPVEAGYTVDLTYATDLFDEASMRVFAARFVR 4671 Query 1445 VVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 V++ P + +++++ + R +LD NA Sbjct 4672 VLDEVVTDPAVVVGDIDLLDDRERSLVLDEWNA 4704 Score = 825 bits (2132), Expect = 0.0, Method: Compositional matrix adjust. Identities = 580/1649 (36%), Positives = 829/1649 (51%), Gaps = 131/1649 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ +P A+ NI ++ R++G +D+ LR AV V RH LRT +P DGV Sbjct 4264 MWFLSRFEPESAVNNIPLAIRLSGGLDVEALRRAVRDVIARHESLRTVFP-DVDGVGTQA 4322 Query 61 VHADLRPGWTQYDLTDLSQRAQRL--RLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 V R +L + L R+E LA A F+L+ D P+R + R A DEH Sbjct 4323 VLPVER---VTIELEPEAVPDGELIGRIESLA----TAGFDLAADVPVRAALFRLADDEH 4375 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGP 166 VL +V HHIA D S D+ AY+ G AD R S Sbjct 4376 VLAIVVHHIASDGFSMAPLARDVMTAYAARSAGEAPAWAPLAVQYADYTLWQREVLGSED 4435 Query 167 DTTEA---DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D+ ++YW +AD PE L+LP V S A + + + +A+ Sbjct 4436 DSESVISRQVSYWTEQLADLPEQLDLPSDRPRPVVASNHGASYRFSIGPELHGAIDAVAR 4495 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 G TP+MV+ A L+ R + + D + PV RG A +D IG F T+ +R Sbjct 4496 ARGVTPFMVVHGALAVLLARLSGTSDIAIGTPVAGRGEAALDDVIGMFVGTLVLRTDVDG 4555 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 F ELL R AF H + +R+V L+P+R + +V F+ D Sbjct 4556 GQPFEELLARIRSTDLAAFEHADLPFERLVEILDPERSQARHPLFQVMLAFQNLDRASLE 4615 Query 343 PPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDN 402 G+ D + + + L VE AG V+ + ++ + A + F +LD Sbjct 4616 LAGLHVSTVDFDAAVAKFDLQVTVEPVEAGYTVDLTYATDLFDEASMRVFAARFVRVLDE 4675 Query 403 ALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEG 462 + P + + L+D+R+ + + + TLVDL + Q RTPDATA+VYEG Sbjct 4676 VVTDPAVVVGDIDLLDDRERSLVLDEWNATDHPVTASTLVDLFDAQAARTPDATALVYEG 4735 Query 463 QHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPS 522 + +Y + R LI +G+G + V + + +SPDL+V V+ +G YVP+DP Sbjct 4736 ESLSYAEFAARVRRTARLLIAEGVGPDSLVGLGVRRSPDLLVGMYAVLAAGGGYVPIDPD 4795 Query 523 YPQDRLDFILADCDAKLVLRTP--------------VRELAGYR-SDDP-TDADRIRPLR 566 P +R +IL + L+L T + EL R SD P TDA+R PLR Sbjct 4796 QPAERNAYILETANPVLLLSTSRDGADLPAAQRVVALDELDVSRFSDAPVTDAERRAPLR 4855 Query 567 PDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAE 626 P NTAY+I+TSG+TG PKGVAV H + W EY + D +LQ +FDVS+ E Sbjct 4856 PGNTAYVIFTSGSTGRPKGVAVGHTAIVNQIEWLCAEYALSADDVVLQKTPFTFDVSLWE 4915 Query 627 IFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQWRTLQ 686 +FGTLA G R+VI P G D YL ++ + +TA FVPS+L F + +L+ Sbjct 4916 LFGTLAVGGRLVIATPDGHRDPAYLKRVIEAQAVTATSFVPSMLTAFTAELAAGDCDSLR 4975 Query 687 RVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGRPKIN 746 V + GE P A +F A A LHN YGPTE ++A+ V G G VP+G P N Sbjct 4976 LVQVAGEAFPTSAAARFAAVNGAELHNLYGPTEFTVHATARPVAGTVGAS-VPMGSPVWN 5034 Query 747 TTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NPGSRMYRSGD 805 + ++LD L+PVP GV GE+Y+ G +A GY RA LTA+RFVA+PF G RMYR+GD Sbjct 5035 SRAYVLDGRLRPVPAGVAGELYLAGAQLARGYFGRADLTADRFVANPFAAAGERMYRTGD 5094 Query 806 LARRNAD----------GDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVS 855 L + G++E++GR D QVK+RG RIELG++ A+ P + Q+VV+V Sbjct 5095 LVKWTVGASEATGDLPAGELEYLGRTDFQVKLRGLRIELGEIETALLARPEITQSVVLVK 5154 Query 856 DLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAH 915 LV YV A G+D+D ++A +AA+L YM+P +VVLD P+ A Sbjct 5155 -----SDQLVAYVV--------ATGGLDVDGVKAELAASLASYMVPQTFVVLDSFPLNAS 5201 Query 916 GKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLAT 975 GK+DR ALPEP + FRAP T+T+ +A +F E+L DRVG DD FF LGG+SL+AT Sbjct 5202 GKLDRKALPEP-VFETRAFRAPTTSTQEIVAGVFAEVLDVDRVGLDDDFFALGGNSLVAT 5260 Query 976 KLVAAVRNAFGVDVGVREIFEFATVTALAGHID-----TLDSDSARPRLTRVDHDGPVRL 1030 ++V+ + A V VRE+FE +TV ALA + T + +ARPR R+ L Sbjct 5261 QVVSRLSRALDTRVPVRELFEASTVEALAARLTQQAGGTRKALTARPRPERIP------L 5314 Query 1031 SSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGG 1090 S +Q R WF RFD + NIP A + G D A A+ DV RHE LRTV+ Sbjct 5315 SLAQQRMWFLNRFDTESTAYNIPLALRMSGNLDMEALDLALADVTERHESLRTVFPATDD 5374 Query 1091 VPHQIIQPPAE--VPVRC--AAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQ 1145 P Q+I P A+ P+R A D L R FD+ +D PIR L T + Sbjct 5375 GPAQVILPAADARTPLRVVDVAPDDLPGRLRALAETR---FDVTSDVPIRVELYRTGADD 5431 Query 1146 TVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDG 1205 VL +VVHHI+ D S L D++TAY AR+ G P W PL VQYADY++WQ +L D Sbjct 5432 FVLGMVVHHISADGVSLAPLTRDVMTAYAARTAGHAPGWTPLAVQYADYALWQREILGDE 5491 Query 1206 A---GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVS 1262 + Q YW L L + L D PRPA+ S G VEF + A L ++ Sbjct 5492 TDPESLAAQQLGYWSETLAELPDQLNLPTDHPRPAVQSFRGGLVEFEIDAPTHRALRDLA 5551 Query 1263 RDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLR 1322 R+ T FM + +A AV+L + G D+ +G P+AGR EA LD L+G F+N +V R + Sbjct 5552 REQNATLFMAVHSAFAVLLSRLSGSDDIAVGTPIAGRGEAELDALVGMFVNTLVFRTRVD 5611 Query 1323 GNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDH 1382 G + +++ R L A+AH D+PF+++VE +NP RS +R+PLF + Q+H Sbjct 5612 GARSFADLVSEVRDTDLEAFAHADVPFERLVEHLNPTRSTARHPLFQVGFSF-----QNH 5666 Query 1383 VIDTGPDGDTTLRVLEPTFDAAQADLSVNFF----ACGDEY---------RGHVIYRTEL 1429 DTG L + T +AA+ + V F D Y + + Y +L Sbjct 5667 --DTG-----ALELPGLTVEAAEIESGVAQFDLHMIVEDHYDDGGDPTGMKASMTYALDL 5719 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRIL-DRSNAGAGTAR---VY 1485 ++ +T + FA+ R++ A +P P+ +V+++ + R R+L +R++ T R V Sbjct 5720 FDESTVRSFAERFARLLAAVVVKPTLPVGDVDLLGLEERARLLVERNDTATATERATLVD 5779 Query 1486 LLDDALKPVPVGVVGDVYYGGGPAVGARL-ARPSETATRFVADPFAAQPGSRLYRNGERG 1544 L D +K P G+ + G A AR + A R +AD P S + + R Sbjct 5780 LFDAQVKATPDGIA--LVSGAERVTYAEFDARVNRLARRLIAD--GVGPESLVALSIRRS 5835 Query 1545 VWKADGQLELLAEIERLPTAQAAPVPAEP 1573 V +LL + + A A VP +P Sbjct 5836 V-------DLLVGMYAVAKAGGAYVPVDP 5857 Score = 791 bits (2044), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/1540 (36%), Positives = 790/1540 (52%), Gaps = 106/1540 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ DP A N+ R+ GD+D+ L+ A+ V RH LRT +P DG Q Sbjct 2160 MWFLNRLDPRSATYNLAFGLRLRGDLDVVALQVALVDVLDRHESLRTVFPDSPDGPHQVV 2219 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V A +LT + L +++ A F+++ + P+R T+ R +HVL Sbjct 2220 VDAVR----VVPNLTPVHVGVDELHRAMVSFA--SAGFDVTTETPVRATLFRIDPFDHVL 2273 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAY-SRADLG-----------ADLGPEHRPSAASGPD- 167 +V HHI+ D S D+ +Y +R G AD R S D Sbjct 2274 AIVVHHISADGWSMGPLARDVMASYDARVRWGQPVWEALPVQYADYALWQRQILGSEDDE 2333 Query 168 --TTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 YW A + P+ L+LP S+R A+ +PAD + +A Sbjct 2334 DSIVAKQARYWSAHLDGLPDQLDLPTDRPRPARQSYRGAKIDFTVPADVHRALIAIAHER 2393 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAM 284 + +MV+ AA L+ R +DD + PV RG +D +G F NT+ +R +S Sbjct 2394 NASLFMVVHAALSVLLSRSAATDDVAIGTPVAGRGEQALDDLVGMFVNTLVLRTHVESGT 2453 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 F +LL+ RD+A GAFA+ I +R+V LNP R + +V F P Sbjct 2454 RFADLLSHARDVALGAFANSDIPFERLVEILNPARSTARHPLIQVMLSFENLGTTHLELP 2513 Query 345 GIECERYDLRSNITQLPLGFMVEFDRA------GVLVEAEHLVEILEPALAKQMLRHFGV 398 + ++ +L + + + L F G+ E + ++ + + + F Sbjct 2514 DLTIDKVELDAEVAKFDLQFTFRESIGEGGLADGMAGEFTYATDLFDASTVQAFADRFLR 2573 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKT-LVDLVNEQTTRTPDATA 457 +L +A PD + + L+ + A+L + D P T L DL+ P+A A Sbjct 2574 ILAAVVADPDTVVGDIDLLGAEEIAQL---TGPAGLDAPAPTPLPDLLAAAADSDPEALA 2630 Query 458 VVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV 517 ++ + TY +L+E S RL L+ +G G ED +AV L +S + + V KSGA +V Sbjct 2631 LIAGVEELTYRELDERSTRLARLLVSRGAGPEDVIAVALTRSVESVTAVWAVAKSGAAFV 2690 Query 518 PVDPSYPQDRLDFILADCDAKLVLRTPVRE--------------------LAGYRSDDPT 557 PVDP+YP+DR+ +++D A L + T LA D + Sbjct 2691 PVDPNYPRDRVAHMVSDSGAVLGVTTSEHADALPDGLPWLVLDDAAVAAGLAEQSVDRLS 2750 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 +ADR+RPL PD+ AY+IYTSG+TG+PKGV V H +A + Y +D R L AS Sbjct 2751 NADRVRPLAPDHPAYVIYTSGSTGVPKGVVVTHTGLAAFAAEQVERYGIDSGSRTLHFAS 2810 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLP 677 PSFD SI E+ A MVI P + LT LL ++ P+ L Sbjct 2811 PSFDASILELLMAFGAAATMVIA-PTSIYGGQELTELLASRHVSHAFVTPAALASV---- 2865 Query 678 GVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRI 737 S L V +GGE ++ ++ AT + N YGPTE + ++ + P Sbjct 2866 DPSALDALGVVVVGGEACSADLVARW-ATGGRKMFNAYGPTEATVASNISDPLVPG--EP 2922 Query 738 VPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN-P 796 V IGR ++LD L+PVP GV+GE+Y+ G +A GYH RAGLTAERFVA+PF P Sbjct 2923 VTIGRAIRGAGTYVLDARLRPVPAGVVGELYLEGAGLARGYHERAGLTAERFVANPFGLP 2982 Query 797 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 856 GSR+YR+GD+ R AD +E+VGRAD+QVK+RGFRIELG++ A + V QAVVVV Sbjct 2983 GSRLYRTGDVVRTTADRVLEYVGRADDQVKLRGFRIELGEIEAVLHRLSDVAQAVVVVRH 3042 Query 857 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 916 + LV Y+ A G +D ++ V ALP YM+PAA VVLDE+PI+ G Sbjct 3043 -----QQLVAYLVAAPGA------SIDPAEVKDTVGRALPAYMVPAAVVVLDELPISGSG 3091 Query 917 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 976 K+DR ALPEP+ EFRAP+T E +A +F ELL RVG DD FF+LGG+SL+AT+ Sbjct 3092 KLDRKALPEPEFEV-REFRAPETPIEEIVAGVFAELLDTPRVGRDDDFFELGGNSLVATR 3150 Query 977 LVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMR 1036 +VA + + VRE+FE +TV ALA I+ RP + + + + LS +Q R Sbjct 3151 VVARIGEGLDTRIPVRELFEASTVQALAARIEQSVGSGRRPLVAKSRPER-IPLSYAQQR 3209 Query 1037 SWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQII 1096 WF RFD +A NNIP A L G D A AA+ DV+ RHE LRTVY EI GV Q+I Sbjct 3210 MWFLNRFDVSSAGNNIPVAVRLSGLLDRTALRAAVGDVIVRHESLRTVYPEIDGVGTQVI 3269 Query 1097 QPPAEVPVR---CAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLVV 1152 +P ++V V A G+D L A L + FD+ + P+RA L +P + VL+LVV Sbjct 3270 RPASQVRVALEPVAIGADE--LPAALGELARWTFDVTREVPLRAELYELSPTEHVLALVV 3327 Query 1153 HHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIV 1209 HHIA D +S G L D++ AY AR G P+W PLPVQYADY++WQ +L DD + Sbjct 3328 HHIAADGFSMGPLTRDIMVAYTARCVGSVPAWQPLPVQYADYALWQREVLGAEDDPDSVF 3387 Query 1210 GPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTE 1269 Q YW +L G + L D PRPA+ SG G F + A+I + A ++ T Sbjct 3388 AQQIAYWRDRLAGAPDQLDLPADRPRPAVASGRGATHRFTVSASIHRAVVAFAKRTNTTP 3447 Query 1270 FMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLRE 1329 FM+ AA++V+ + G D+ IG PVAGR E+ +D L+G F+N +VLR ++ G+ + Sbjct 3448 FMVFHAALSVLAARLSGTSDISIGTPVAGRGESAIDDLVGMFVNTLVLRTEVDGDRSFEA 3507 Query 1330 VLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVRE------QMPQDHV 1383 +++ R+ L A+AH D+PF+++VE + P RS +RNPLF +++ + ++P V Sbjct 3508 LVESVRETDLGAFAHSDVPFERLVEVLAPARSQARNPLFQVMLAFQNLGRTSFELPGVTV 3567 Query 1384 IDTGPDG-----DTTLRVLEPTFDAAQA-DLSVNFFACGDEYRGHVIYRTELYERATAQR 1437 + D D + V+E DA A L+V Y T+L+E AT Sbjct 3568 SEVDFDEVFSKFDIQVSVMESIDDAGTAGGLTVEL-----------TYATDLFEAATMAE 3616 Query 1438 FADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 F LVR++ A P + +V ++ A R R+++ NA Sbjct 3617 FGTRLVRILSAVLADPSVAVGDVALLDAAERSRVVEDWNA 3656 Score = 753 bits (1944), Expect = 0.0, Method: Compositional matrix adjust. Identities = 518/1537 (34%), Positives = 768/1537 (50%), Gaps = 106/1537 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + A+ N+ + R++G +D A V RH LRT YP DGVA+ Sbjct 1094 MWFLNRFDATTAVYNLPFAVRLSGAVDPQAFSAAFADVVERHESLRTVYP-EVDGVARQV 1152 Query 61 VHA------DLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTA 114 V DL P T D DL RL A R F +++ + P RI ++R + Sbjct 1153 VLPARDVVRDLEPVATAAD--DLEPTLLRL-----ASRGF----DVTSEPPFRIELLRLS 1201 Query 115 ADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD--------------------L 154 E+V+ +V HHIA D S+ DL AY+ GA L Sbjct 1202 DAEYVVAMVLHHIAADGSSFGPLARDLMIAYAARSEGAAPAWEPLPVQYADYAVWQHEML 1261 Query 155 GPEHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADT 214 G E P++ +G + YW +A P+ L+LP S A+ + A T Sbjct 1262 GSETDPNSIAG-----QQIAYWTEALAGLPDQLDLPADRPRPAVASNAGAKLRFDISAQT 1316 Query 215 AARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA-IGYFGNT 273 AR+ +A+ G T +MV+ AA+ L+ R + + D V PV RG D IG F NT Sbjct 1317 HARLLDVAREHGATLFMVVHAAYAMLLARLSGTSDIAVGTPVAGRGDQALDGLIGMFVNT 1376 Query 274 VAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSF-- 331 + +R + ++F +L+ A + A+ + + + +V L P R + + Sbjct 1377 LVLRTQVDPDITFADLIDAVKTADLEAYGNADVPFEWLVEALEPTRSPARHPLFQAMLSA 1436 Query 332 ---GFREPDGGGFNPPGIECE----RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEIL 384 G R+ G E + ++DL+ I++ GF A + E+ ++ Sbjct 1437 EVAGVRDLSFAGVRAAAAELDVPVSKFDLQLQISE---GFDESGAPASIGAVFEYATDLF 1493 Query 385 EPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDL 444 + + F +LD ++ T+ + L+DE + R+ + P TL +L Sbjct 1494 DESTVATFAERFVRILDAIVSDTTVTVGDVCLLDETEQRRVVHEWNRTGHELPAVTLPEL 1553 Query 445 VNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIV 504 + Q TP A AVV+ +TY + NRL L+ G+G E VAV +++SP+L+ Sbjct 1554 FDRQAAATPSAPAVVFATGSWTYEEFASRVNRLARHLVGLGVGPESVVAVAMERSPELLT 1613 Query 505 TALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP----------------VREL 548 V+ +G YVP+DP P +R IL VL T +L Sbjct 1614 AVYAVLAAGGAYVPIDPQQPAERNTHILGTAGPSCVLTTSDDDIDLPEHVQRVDVDTLDL 1673 Query 549 AGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDD 608 + TDA R PLRP+N AY+++TSG+TG PKGV + H V + + EY + Sbjct 1674 SAMSPARLTDAARRAPLRPENAAYVLFTSGSTGRPKGVTISHSAVVNQLLSMQDEYRLGA 1733 Query 609 TDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPS 668 D +L +FD S+ E+F L GAR+V+ P G D YL +L ++ IT + FVP+ Sbjct 1734 DDSVLFKTPVTFDASVWELFWPLESGARIVVAAPDGHRDPAYLARILAEQAITVVQFVPT 1793 Query 669 LLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFK 728 +L +L V GGEPL V + + DA +HN YGPTET + +R Sbjct 1794 VLDAVADHLERQGCVSLTHVFCGGEPLTTAVVSRVRSICDAAIHNLYGPTETAVQVTRRT 1853 Query 729 VVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAER 788 V G + + VPIG P N+ + +LD L PVP GV+GE+Y+ G +A GY R+ LT+ER Sbjct 1854 VAGTE-SAAVPIGAPVWNSQVRVLDSRLNPVPAGVVGELYVSGAQLARGYRGRSDLTSER 1912 Query 789 FVADPFNPGSRMYRSGDLARRNAD----GDIEFVGRADEQVKIRGFRIELGDVAAAIAVD 844 FVADP+ PG RMYR+GDL R D G++E+VGR+D QVK+RG RIELG+V A+ Sbjct 1913 FVADPWAPGERMYRTGDLVRWIVDADGAGELEYVGRSDFQVKLRGLRIELGEVETAVREH 1972 Query 845 PTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAY 904 +V QAVV + PR G LV YV + P D +R ++ LP YM+P + Sbjct 1973 GSVSQAVVALHHDPRAGDQLVAYVVASTECAVPFDPA----NLREHLSLRLPSYMVPTMF 2028 Query 905 VVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSF 964 + +D +P T GKIDR ALP P + + FR P+T E +A + ++LG + VG DD F Sbjct 2029 LPIDALPRTTSGKIDRRALPVPVFEAKS-FRIPRTPVEEIVADVLADVLGVETVGLDDEF 2087 Query 965 FDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDH 1024 F LGG+SL+AT++VA + A V VR +FE +TV LA ++ R L + Sbjct 2088 FALGGNSLIATQVVARLGAALDTSVPVRVLFESSTVEQLAVRVEQHAGAGNRAPLVAQER 2147 Query 1025 DGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTV 1084 + LS +Q R WF R D +A N+ F L G D A A+ DV+ RHE LRTV Sbjct 2148 PDRIPLSLAQQRMWFLNRLDPRSATYNLAFGLRLRGDLDVVALQVALVDVLDRHESLRTV 2207 Query 1085 YREIGGVPHQIIQP-----PAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAAL 1139 + + PHQ++ P PV G D L + + FD+ T+ P+RA L Sbjct 2208 FPDSPDGPHQVVVDAVRVVPNLTPVHV--GVDE--LHRAMVSFASAGFDVTTETPVRATL 2263 Query 1140 LST-PEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQ 1198 P VL++VVHHI+ D WS G L D++ +Y AR +P W LPVQYADY++WQ Sbjct 2264 FRIDPFDHVLAIVVHHISADGWSMGPLARDVMASYDARVRWGQPVWEALPVQYADYALWQ 2323 Query 1199 SALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIR 1255 +L DD IV Q YW L GL + L D PRPA S G ++F + A + Sbjct 2324 RQILGSEDDEDSIVAKQARYWSAHLDGLPDQLDLPTDRPRPARQSYRGAKIDFTVPADVH 2383 Query 1256 DKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIV 1315 L A++ + + FM++ AA++V+L ++ DV IG PVAGR E LD L+G F+N + Sbjct 2384 RALIAIAHERNASLFMVVHAALSVLLSRSAATDDVAIGTPVAGRGEQALDDLVGMFVNTL 2443 Query 1316 VLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVR 1375 VLR + ++L R +AL A+A+ D+PF+++VE +NP RS +R+PL +++ Sbjct 2444 VLRTHVESGTRFADLLSHARDVALGAFANSDIPFERLVEILNPARSTARHPLIQVMLSF- 2502 Query 1376 EQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFF------ACGDEYRGHVIYRTEL 1429 E + H+ D T+ +E + A+ DL F D G Y T+L Sbjct 2503 ENLGTTHL----ELPDLTIDKVELDAEVAKFDLQFTFRESIGEGGLADGMAGEFTYATDL 2558 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQ 1466 ++ +T Q FAD +R++ A PD + +++++ A+ Sbjct 2559 FDASTVQAFADRFLRILAAVVADPDTVVGDIDLLGAE 2595 Score = 690 bits (1781), Expect = 0.0, Method: Compositional matrix adjust. Identities = 428/1073 (40%), Positives = 589/1073 (55%), Gaps = 48/1073 (4%) Query 439 KTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDK 498 + L + +EQ RTP ATA+V+EG+ TY +L+ +N L LI G+G E V + + + Sbjct 480 RNLAEAFDEQVARTPGATALVFEGETLTYAELDARANALARTLIGIGVGPESLVGLSIRR 539 Query 499 SPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP-------------- 544 S DLIV +VKSG +VP+DP +P DR +IL VL T Sbjct 540 SLDLIVGLYAIVKSGGAWVPIDPDHPADRTAYILESAGPACVLTTARDAVDLPAGIVSIE 599 Query 545 --VRELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKG 602 +L + TDADR+ PLRP+NTAY+IYTSG+TG PKGVAV H + W Sbjct 600 IDTIDLPALDTRTVTDADRLAPLRPENTAYVIYTSGSTGRPKGVAVSHAAIDNQLEWMLH 659 Query 603 EYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITA 662 EY + ++D LQ + +FDVS+ F L GA MVI P G D Y+ + + +T Sbjct 660 EYPMTESDAYLQKTATTFDVSLWGFFMPLRVGASMVIATPDGHRDPVYVANKIAEHSVTV 719 Query 663 MHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVI 722 FVPS+L +F++ +L+ + GE LP E A F A LHN YGPTE + Sbjct 720 TDFVPSMLTVFVANAPAGSCDSLRDCFVIGEALPPETAADFRELCGAGLHNLYGPTEAAV 779 Query 723 NASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRA 782 + + ++ GPQ T VPIG + NT ++LD L+P P G GE+Y+ G +A GY R Sbjct 780 SVTYYE-SGPQDTATVPIGLAEWNTRAYVLDHRLRPAPIGQPGELYLAGDQLARGYVGRP 838 Query 783 GLTAERFVADPFN-------PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 +T++RFVA+PF G RMYR+GDL R ADG+++++GR D QVK RG RIELG Sbjct 839 DITSDRFVANPFGGLDGVGRAGERMYRTGDLVRWRADGNLDYIGRTDFQVKFRGQRIELG 898 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++ + V Q VV+V G LV YV PA G V DL R +L Sbjct 899 EIETVLLAHEDVSQTVVLVVSTAT-GDQLVAYVVPAPGR---TLVPADLAEFAGR---SL 951 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P YM+PA+ VLD P+ GK+DR ALPEP S+ EFRAP++ E+ +A ++ E+LG Sbjct 952 PAYMVPASVTVLDAFPLNTSGKLDRKALPEPTFLSNKEFRAPRSDAEKTVAAVYAEVLGI 1011 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHI-DTLDSDS 1014 +RVG DD FF+LGG+SL+AT++V V A V +GVRE+FE +TV ALA DT + Sbjct 1012 ERVGLDDDFFELGGNSLVATQVVTRVGAALDVRLGVRELFEASTVAALAARAGDTAQRGT 1071 Query 1015 ARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDV 1074 P L V + LS +Q R WF RFD AV N+PFA L G D AF+AA DV Sbjct 1072 GVPALGSVARPASIPLSLAQQRMWFLNRFDATTAVYNLPFAVRLSGAVDPQAFSAAFADV 1131 Query 1075 VARHEILRTVYREIGGVPHQIIQPPAEV-----PVRCAAGSDAAWLRAELNNERGYVFDL 1129 V RHE LRTVY E+ GV Q++ P +V PV AA L L FD+ Sbjct 1132 VERHESLRTVYPEVDGVARQVVLPARDVVRDLEPVATAADD----LEPTLLRLASRGFDV 1187 Query 1130 ETDWPIRAALLSTPE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLP 1188 ++ P R LL + + V+++V+HHIA D S G L DL+ AY ARS G P+W PLP Sbjct 1188 TSEPPFRIELLRLSDAEYVVAMVLHHIAADGSSFGPLARDLMIAYAARSEGAAPAWEPLP 1247 Query 1189 VQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDA 1245 VQYADY+VWQ +L D I G Q YW L GL + L D PRPA+ S AG Sbjct 1248 VQYADYAVWQHEMLGSETDPNSIAGQQIAYWTEALAGLPDQLDLPADRPRPAVASNAGAK 1307 Query 1246 VEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLD 1305 + F + A +L V+R+ G T FM++ AA A++L + G D+ +G PVAGR + LD Sbjct 1308 LRFDISAQTHARLLDVAREHGATLFMVVHAAYAMLLARLSGTSDIAVGTPVAGRGDQALD 1367 Query 1306 QLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRN 1365 LIG F+N +VLR + + T +++ + L AY + D+PF+ +VEA+ P RS +R+ Sbjct 1368 GLIGMFVNTLVLRTQVDPDITFADLIDAVKTADLEAYGNADVPFEWLVEALEPTRSPARH 1427 Query 1366 PLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYR-GHVI 1424 PLF ++ +D L V FD Q +S F G G V Sbjct 1428 PLFQAMLSAEVAGVRDLSFAGVRAAAAELDVPVSKFD-LQLQISEGFDESGAPASIGAVF 1486 Query 1425 -YRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 Y T+L++ +T FA+ VR+++A + +V ++ +RR++ N Sbjct 1487 EYATDLFDESTVATFAERFVRILDAIVSDTTVTVGDVCLLDETEQRRVVHEWN 1539 Score = 64.7 bits (156), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 84/265 (32%), Positives = 109/265 (42%), Gaps = 99/265 (37%) Query 1472 LDRSNAGAGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAA 1531 + R+ GAGT Y+LD L+PVP GVVG++Y G R TA RFVA+PF Sbjct 2925 IGRAIRGAGT---YVLDARLRPVPAGVVGELYLEGAGLARGYHERAGLTAERFVANPFGL 2981 Query 1532 QPGSRLYRNGE----------RGVWKADGQLEL------LAEIE----RLP-TAQAAPV- 1569 PGSRLYR G+ V +AD Q++L L EIE RL AQA V Sbjct 2982 -PGSRLYRTGDVVRTTADRVLEYVGRADDQVKLRGFRIELGEIEAVLHRLSDVAQAVVVV 3040 Query 1570 ------------------PAEPADTETERAL-------AAILADVLEVGEVGRYD----- 1599 PAE DT RAL A ++ D L + G+ D Sbjct 3041 RHQQLVAYLVAAPGASIDPAEVKDT-VGRALPAYMVPAAVVVLDELPISGSGKLDRKALP 3099 Query 1600 -------------------------------------DFFNLGGDSILATQVAARARDG- 1621 DFF LGG+S++AT+V AR +G Sbjct 3100 EPEFEVREFRAPETPIEEIVAGVFAELLDTPRVGRDDDFFELGGNSLVATRVVARIGEGL 3159 Query 1622 --GIPLTARMVFEHPVLCELAAAVD 1644 IP+ R +FE + LAA ++ Sbjct 3160 DTRIPV--RELFEASTVQALAARIE 3182 Score = 60.8 bits (146), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 30/78 (39%), Positives = 44/78 (57%), Gaps = 5/78 (6%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFA-----AQPGSRL 1537 R Y+LD L+P P+G G++Y G + RP T+ RFVA+PF + G R+ Sbjct 804 RAYVLDHRLRPAPIGQPGELYLAGDQLARGYVGRPDITSDRFVANPFGGLDGVGRAGERM 863 Query 1538 YRNGERGVWKADGQLELL 1555 YR G+ W+ADG L+ + Sbjct 864 YRTGDLVRWRADGNLDYI 881 Score = 60.1 bits (144), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 33/73 (46%), Positives = 41/73 (57%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RVY+LD L PVP GV G++Y G R TA RFVADP+A G R+YR G+ Sbjct 6098 RVYVLDSRLNPVPAGVTGELYLAGVQLARGYHGRADLTADRFVADPWAT--GERMYRTGD 6155 Query 1543 RGVWKADGQLELL 1555 W A +LE + Sbjct 6156 VVRWNASDELEYV 6168 Score = 57.8 bits (138), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/73 (46%), Positives = 43/73 (59%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R ++LD+ L PVPVGV G++Y G AR TA RFVA+PF + G R+YR G+ Sbjct 3988 RAFVLDERLNPVPVGVPGELYLAGVQLARGYAARTDLTADRFVANPF-SDSGERMYRTGD 4046 Query 1543 RGVWKADGQLELL 1555 DG+LE L Sbjct 4047 LVRRTRDGRLEYL 4059 Score = 57.4 bits (137), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/76 (45%), Positives = 44/76 (58%), Gaps = 4/76 (5%) Query 1481 TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 ++V +LD L PVP GVVG++Y G R T+ RFVADP+A PG R+YR Sbjct 1870 NSQVRVLDSRLNPVPAGVVGELYVSGAQLARGYRGRSDLTSERFVADPWA--PGERMYRT 1927 Query 1541 GE--RGVWKADGQLEL 1554 G+ R + ADG EL Sbjct 1928 GDLVRWIVDADGAGEL 1943 Score = 53.1 bits (126), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 38/89 (43%), Positives = 52/89 (59%), Gaps = 11/89 (12%) Query 1565 QAAPVPAEPAD------TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR- 1617 +A PVP A T E +A +LADVL V VG D+FF LGG+S++ATQV AR Sbjct 2045 RALPVPVFEAKSFRIPRTPVEEIVADVLADVLGVETVGLDDEFFALGGNSLIATQVVARL 2104 Query 1618 --ARDGGIPLTARMVFEHPVLCELAAAVD 1644 A D +P+ R++FE + +LA V+ Sbjct 2105 GAALDTSVPV--RVLFESSTVEQLAVRVE 2131 Score = 52.8 bits (125), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/98 (40%), Positives = 53/98 (55%), Gaps = 12/98 (12%) Query 1574 ADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMV 1630 A T E +A ADVL + VG DDFF LGG+S++ATQ+ AR A D +P+ R+V Sbjct 6278 ATTPIEEIVAGAFADVLGIERVGLDDDFFELGGNSLVATQLVARLGAALDTQVPV--RVV 6335 Query 1631 FEHPVLCELAAAVD------AKPHVEAEPDDKHHAPMS 1662 FE + +A AV +P + A P H P+S Sbjct 6336 FEDSTVAGVAGAVTPLVGQGGRPALTARPRPP-HVPLS 6372 Score = 51.6 bits (122), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/71 (46%), Positives = 45/71 (64%), Gaps = 5/71 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFE 1632 T T+ +A + ADVL++ VG DDFF LGG+S++ATQV +R A D +P+ R +FE Sbjct 4166 TPTQEIVAGVFADVLDLDRVGLDDDFFALGGNSLVATQVVSRLGAALDTQVPV--RALFE 4223 Query 1633 HPVLCELAAAV 1643 + LAA V Sbjct 4224 ASTVESLAARV 4234 Score = 50.4 bits (119), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/69 (45%), Positives = 44/69 (64%), Gaps = 5/69 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVA---ARARDGGIPLTARMVFE 1632 T T+ +A + A+VL+V VG DDFF LGG+S++ATQV +RA D +P+ R +FE Sbjct 5224 TSTQEIVAGVFAEVLDVDRVGLDDDFFALGGNSLVATQVVSRLSRALDTRVPV--RELFE 5281 Query 1633 HPVLCELAA 1641 + LAA Sbjct 5282 ASTVEALAA 5290 Score = 49.7 bits (117), Expect = 0.005, Method: Compositional matrix adjust. Identities = 116/473 (25%), Positives = 175/473 (37%), Gaps = 62/473 (13%) Query 1027 PVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR 1086 P LS +Q+ WF D P+ NI L G D A Sbjct 30 PFPLSQAQLGMWFAQHVD-PSVPANIAQYVELRGELDIARLHRASARAAGETGSGYVRLL 88 Query 1087 EIGGVPHQIIQP-----PAEVPVRCAAGSDAA---WLRAELNNERGYVFDLETDWPIRAA 1138 E+ P Q++ P V +R AA W+RA+ + DL D + AA Sbjct 89 EVDAEPRQLVDTTLDDTPEYVDLRSEPDPRAAALAWMRADYSAP----VDLLRDRLVVAA 144 Query 1139 LLSTPEQTVLSLV-VHHIAGDHWSAGVLFTDLLTAYRARSTGQRPS---WAPLPVQY-AD 1193 +L + HH+ D + A + Y A G PS +PL Y AD Sbjct 145 VLHVEDGLYYWYNRAHHVVLDGFGATTFVNRVAELYSAEVDGVEPSPNVASPLEKVYDAD 204 Query 1194 YSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAA 1253 + S RDYW+ ++ G+ T L PA LS D+ G A Sbjct 205 RTYRSSTRFTS-------DRDYWLERVAGVEEPTSLAGRAAPPAPLSRI-DSAALSDGTA 256 Query 1254 IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFIN 1313 R + A T + AA A L + G DV + PV R+ A L + G N Sbjct 257 AR--MDAFLEREDTTVATAVIAAFAAYLAQMTGREDVVLSLPVTARTNAVLRRSGGMTSN 314 Query 1314 IVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQV---VEAVNPQRSLSRNPLFDI 1370 +V LR + + T+ ++L A HQ + + V Q S P +I Sbjct 315 VVPLRLTVSADTTVSQLLGLVATEVSGALRHQRYRHEDIRRDVTGAAGQASFF-GPWVNI 373 Query 1371 VVHVRE-----QMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIY 1425 ++ E + + H++ TG ++E DL VN + HV + Sbjct 374 MMFHTELRFGDTVGEQHILSTG--------LIE--------DLGVNVYQGIAGSTTHVDF 417 Query 1426 RT--ELY----ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRIL 1472 + LY R +RF ++L R V A + +QP+ E+ + + RR +L Sbjct 418 ESNPNLYGDDEARRNHERFVEFLDRYVAAGS---EQPVWELPLGTDVERRTVL 467 Score = 49.7 bits (117), Expect = 0.005, Method: Compositional matrix adjust. Identities = 85/330 (26%), Positives = 131/330 (40%), Gaps = 25/330 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF Q DPS NI + G++D+ARL A AR + Y + A+P Sbjct 40 MWFAQHVDPSVP-ANIAQYVELRGELDIARLH---RASARAAGETGSGYVRLLEVDAEPR 95 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 D T + S+ R + ++ AP +L RD + V+ + Sbjct 96 QLVDTTLDDTPEYVDLRSEPDPRAAALAWMRADYSAPVDLLRDRLVVAAVLHVEDGLYYW 155 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT----------- 169 AHH+ D F + + YS A++ G E P+ AS + Sbjct 156 YNRAHHVVLDGFGATTFVNRVAELYS-AEVD---GVEPSPNVASPLEKVYDADRTYRSST 211 Query 170 --EADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGC 227 +D +YW +A EP L G A P S + A L TAAR+ + Sbjct 212 RFTSDRDYWLERVAGVEEPTSLAGRAAPPAPLSRIDSAA---LSDGTAARMDAFLEREDT 268 Query 228 TPYMVLLAAFGALVHRYTHSDDFLVAAPVLNR-GAGTEDAIGYFGNTVAMRLRPQSAMSF 286 T ++AAF A + + T +D +++ PV R A + G N V +RL + + Sbjct 269 TVATAVIAAFAAYLAQMTGREDVVLSLPVTARTNAVLRRSGGMTSNVVPLRLTVSADTTV 328 Query 287 RELLTATRDIASGAFAHQRINLDRVVRELN 316 +LL SGA HQR + + R++ Sbjct 329 SQLLGLVATEVSGALRHQRYRHEDIRRDVT 358 Score = 49.3 bits (116), Expect = 0.007, Method: Compositional matrix adjust. Identities = 28/67 (42%), Positives = 41/67 (62%), Gaps = 1/67 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 ++ E+ +AA+ A+VL + VG DDFF LGG+S++ATQV R + L R +FE Sbjct 995 SDAEKTVAAVYAEVLGIERVGLDDDFFELGGNSLVATQVVTRVGAALDVRLGVRELFEAS 1054 Query 1635 VLCELAA 1641 + LAA Sbjct 1055 TVAALAA 1061 >gi|325675435|ref|ZP_08155119.1| exopolyphosphatase [Rhodococcus equi ATCC 33707] gi|325553406|gb|EGD23084.1| exopolyphosphatase [Rhodococcus equi ATCC 33707] Length=3567 Score = 854 bits (2206), Expect = 0.0, Method: Compositional matrix adjust. Identities = 563/1527 (37%), Positives = 811/1527 (54%), Gaps = 96/1527 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ +P A+ NI ++ R++GD+D+ L A+ V RH LRT +P DGV Sbjct 1782 MWFLNRFEPESAVNNIPLAIRLSGDLDVESLSAAIGDVLERHESLRTVFP-DVDGVG--- 1837 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + +RP ++ T ++ L L +R A F+L+ D P+R+ + + EHVL Sbjct 1838 -YQSIRPA-SEVAGTVTAEAVTEADLPALVERMVVAGFDLTTDIPVRVGLFAVSPTEHVL 1895 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------AD--------LGPEHRP 160 +LV HHIA D S D+ AY+ G AD LG E P Sbjct 1896 VLVVHHIAADGFSMGPLTRDVMTAYAARSAGTLPAWAPLAVQYADYTLWQREVLGSEDDP 1955 Query 161 SAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVAT 220 + P +T+ + YW+ +A P+ L+LP +R AR T+ +PAD + +A Sbjct 1956 ES---PMSTQ--VAYWKRTLAGLPDQLDLPTDRPRPAVAGYRGARHTVEVPADLQSAIAE 2010 Query 221 MAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLR 279 +A+ G TP+MV+ AA L+ R + + D + PV RG A +D IG F NT+ +R Sbjct 2011 LARTRGVTPFMVMHAALSVLLARLSGTSDIAIGTPVAGRGEAVLDDVIGMFVNTLVLRTE 2070 Query 280 PQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGG 339 +A SF +LL TR+ AF H + +R+V L+P R + +V F+ Sbjct 2071 VDAAGSFEDLLARTRETDLAAFGHADVPFERLVEILDPARSQARHPLFQVMLTFQNLGLT 2130 Query 340 GFNPPGIECERYDLRSNITQLPLGFMVEF---DRAGVLVEAEHLVEILEP----ALAKQM 392 F G+ + S + L V DR G+ ++ + E+ + L + Sbjct 2131 SFELGGLAVSDVEFDSTTAKFDLQVTVTEGAPDR-GLTIDLTYATELFDADTIRILGDRC 2189 Query 393 LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDT----PVKTLVDLVNEQ 448 LR V+ A P + + L+DE + R + GE T P TLVDL Q Sbjct 2190 LRVLSVVT----ATPSAVVGDIDLLDEVE----RSLVVGEWNATSRPVPDATLVDLFEAQ 2241 Query 449 TTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALG 508 RTPDA AVV+EG+ +Y + R LI +G+G + V + + +S DL+V Sbjct 2242 VARTPDAVAVVFEGESLSYAEFASRVRRTARLLIAEGVGPDSLVGLGMRRSVDLLVGMYA 2301 Query 509 VVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTP--VRELAGYRS------------D 554 V+ +G YVP+DP P +R +ILA + L+L T ++ G RS D Sbjct 2302 VLAAGGAYVPIDPDQPAERNRYILATANPVLLLTTSRDAGDVPGLRSVEIDTVDVSDFAD 2361 Query 555 DP-TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLL 613 P D +R PLR NTAY+I+TSG+TG PKGVAV H + VW + EY + D +L Sbjct 2362 GPIADVERNAPLRSGNTAYVIFTSGSTGRPKGVAVGHGAIVNRLVWMQAEYGLAAADVVL 2421 Query 614 QVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLF 673 Q +FDVS+ E F L GAR+V+ P G D YL ++ + G+T HFVPS+L +F Sbjct 2422 QKTPFTFDVSVWEFFWPLQVGARLVVALPDGHRDPAYLVRVMVECGVTVAHFVPSMLSVF 2481 Query 674 LSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATF-DALLHNFYGPTETVINASRFKVVGP 732 ++ P TL+ V GE LP A + A LHN YGPTE ++ + F V Sbjct 2482 VAEPAAKNVTTLRNVFASGEALPASTAARLRDVVPGAALHNLYGPTEAAVDVT-FHEVTV 2540 Query 733 QGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVAD 792 VPIG P NT + +LD L+PVP GV GE+Y+ G +A GY RA LTA+RFVA+ Sbjct 2541 DDEATVPIGGPVWNTQLFVLDGRLKPVPVGVPGELYLAGVQLARGYVSRADLTADRFVAN 2600 Query 793 PFN-PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAV 851 PF+ G RMYR+GDL R +ADG++E++GR D QVK+RG RIELG++ A+ P + Q+V Sbjct 2601 PFSGSGERMYRTGDLVRWSADGELEYIGRTDFQVKLRGLRIELGEIETALLAVPGISQSV 2660 Query 852 VVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIP 911 V+V + LV YV AD +D ++A+++ +L YM+P +VVLD P Sbjct 2661 VLVRN-----DQLVAYVV--------ADQDLDTTAVKAQLSTSLASYMVPQMFVVLDAFP 2707 Query 912 ITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHS 971 + A GK+DR ALPEP + T FRAP TA E +A +F ++LG DRVG DD FF LGG+S Sbjct 2708 LNASGKLDRKALPEP-VFEATVFRAPTTAAEEVVAGVFADVLGVDRVGLDDDFFALGGNS 2766 Query 972 LLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLS 1031 L+AT++ A + A V VR +F+ +TV ALA + +L AR L V LS Sbjct 2767 LVATQVAARLGAALDAQVPVRVLFDASTVQALAARVQSLAGAGARKALVAGPRPERVPLS 2826 Query 1032 SSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGV 1091 +Q R WF R + + NIP A L G D +A AA+ DV+ARHE LRT Y E Sbjct 2827 LAQQRMWFLNRLEPESTSYNIPLAMQLTGSLDVDALHAALRDVLARHESLRTFYPEDADG 2886 Query 1092 PHQIIQPPAEVPVRCAAGS-DAAWLRAELNNERGYVFDLETDWPIRAALLSTPEQT-VLS 1149 PHQ+I P A+V S D A ++ G FD+ + P+RA L + T V + Sbjct 2887 PHQVIAPAADVEFDLTPISVDPADAYGRVSELVGKGFDVRSAVPLRAGLFRLDDTTHVFA 2946 Query 1150 LVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGA 1206 VVHHI+ D S + DL+TAY AR+ G+ P W PLPVQYADY++WQ +L D+ Sbjct 2947 FVVHHISADGVSMAPMARDLVTAYAARTQGEAPQWQPLPVQYADYALWQREVLGSADEPG 3006 Query 1207 GIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLG 1266 + Q +W+R L G + L D PRPA+ S G EF L A + L +++R G Sbjct 3007 TVAAAQLAHWVRALAGAPDQLDLPTDRPRPAVASMRGAETEFTLSAELHAALESLARAEG 3066 Query 1267 VTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPT 1326 V+ FM+ +A+AV+L + G DV +G PVAGR EA LD L+G F+N + LR +L + Sbjct 3067 VSLFMVAHSALAVLLARLSGTWDVTVGTPVAGRGEAALDDLVGMFVNTLALRTELTSSMR 3126 Query 1327 LREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDT 1386 EV+ R ++ L+A+A+ DLPF++VVEAV+ RS +R+P+F V+ + Q Q + Sbjct 3127 FTEVVARAKEADLSAFANADLPFERVVEAVSSDRSSARHPVFQTVLSFQNQ-EQATLALP 3185 Query 1387 GPDGDTTLRVLEPTFDAAQADLSVNFFAC-GDEYRGHVIYRTELYERATAQRFADWLVRV 1445 G T+ + T AA+ DL + Y T+L++ AT + VR+ Sbjct 3186 G----LTVSSVPDTDRAAKFDLQFTLIPTDSGTVEAILTYATDLFDEATVVTLGERFVRI 3241 Query 1446 VEAFADRPDQPLREVEMVSAQARRRIL 1472 +EA A P + ++E+V+ +A R +L Sbjct 3242 LEAVAADPHAVVGDIEIVT-EAERALL 3267 Score = 713 bits (1841), Expect = 0.0, Method: Compositional matrix adjust. Identities = 547/1566 (35%), Positives = 797/1566 (51%), Gaps = 126/1566 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D A NI V+ R+TG +D+ LR+AV+ V RH LRT +P D +Q Sbjct 736 MWFLNRFDTESAANNIVVAIRLTGALDVDALREAVSDVIERHESLRTVFPEIDGAASQVI 795 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + AD + DL R + V R F+++ PLR+ ++ EHVL Sbjct 796 LPAD----RVKVDLAAEPVRESDVADAV--ARTISQGFDVTAAVPLRMRLLAVTPTEHVL 849 Query 121 LLVAHHIAWDDGSWRVFFTDLTQA------------------------YSRADLGADLGP 156 ++V HHI+ D S D+ A + R LG++ P Sbjct 850 VVVVHHISADGFSMNPLTRDIVTAYAARSAGAAPSWAPLAVQYADYALWQREVLGSEDDP 909 Query 157 EHRPSAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAA 216 E + +WR +AD P+ L+LP S A + A+TAA Sbjct 910 ES---------VIAQQMQFWRGALADLPDRLDLPADRPRPAVASNNGASHRFSIGAETAA 960 Query 217 RVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVA 275 R+ +A++ G + +MV+ AA L+ R + + D + PV RG A +D +G F NT+ Sbjct 961 RLDAIARDHGASTFMVVHAALSVLLARLSGTSDIAIGTPVAGRGEAALDDLVGMFVNTLV 1020 Query 276 MRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFRE 335 +R + F ELLT R AF H + +R+V L+P R + +V+ F+ Sbjct 1021 LRADVRGDRPFTELLTGVRATDLEAFGHADVPFERLVEALSPARSQSRHPLFQVALSFQN 1080 Query 336 PDGGGFNPPGIECERYDLRSNITQLPLGFMV-EFDRA-GVL-VEAEHLVEILEPALAKQM 392 D + D + + + L V E D A G L V+ + ++ + + + Sbjct 1081 MDRTDLALGDLTVSGVDFDAAVAKFDLAVTVAESDSATGALDVDLTYATDLFDASTMRVF 1140 Query 393 LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT 452 F +L+ A + + ++D + + L S G+ P+ L +++ + Sbjct 1141 ADRFVRVLEAVAADASVVVGDIDVLDAAERSALTAAS-GDAGPAPM-LLPQILSAAASAD 1198 Query 453 PDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKS 512 P A+V + Y DL+E S+RL LI +G G E VAV L +S + +V V KS Sbjct 1199 PARAALVSGERTVAYRDLDEQSSRLARALIARGAGPETVVAVALTRSIESVVAVWAVAKS 1258 Query 513 GAVYVPVDPSYPQDRLDFILADCDAKL------------------VLRTPVR--ELAGYR 552 GA +VPVDP YP DR+ ++ D A L VL P E+A Sbjct 1259 GAAFVPVDPHYPADRVAHMVTDSRALLGITRTEHEGALPAAVPWLVLDDPATADEVAAQP 1318 Query 553 SDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRL 612 +DADR PLR + AY+IYTSG+TG+PKGV V H +A + Y +D R Sbjct 1319 DAPVSDADRTAPLRVTDAAYVIYTSGSTGVPKGVVVTHTGLAAFAAEQVERYGIDSDSRT 1378 Query 613 LQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGL 672 L ASPSFD SI E+ GA MVI P + L LLR + +T P+ L Sbjct 1379 LHFASPSFDASILELLMAFGAGATMVIA-PTSIYGGHELADLLRTQHVTHAFVTPAALA- 1436 Query 673 FLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGP 732 + G+ RT V +GGE E+ ++ + N YGPTE + ++ + P Sbjct 1437 SVDPAGLEALRT---VVVGGEACSAELVARWAP--GRRMFNAYGPTEATVASNISDALVP 1491 Query 733 QGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVAD 792 V IGR ++LD L+PVP GV GE+Y+ G VA GY R L+AERFVA+ Sbjct 1492 G--EPVTIGRAIRGADAYVLDGRLRPVPAGVPGELYLAGAGVARGYLGRPALSAERFVAN 1549 Query 793 PFN-PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAV 851 PF PGSR+YR+GD+ AD +E+VGRAD+QVK+RGFRIELG++ + +A TV Q Sbjct 1550 PFGMPGSRLYRTGDVVLTTADRVLEYVGRADDQVKLRGFRIELGEIESVLARHDTVAQTA 1609 Query 852 VVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIP 911 VVV L LV YV A AD +++ ++ A +L YM+PA +VVLD +P Sbjct 1610 VVV-----LRDQLVAYVVAA------ADRSIEVAELKEFAARSLTAYMVPAVFVVLDRLP 1658 Query 912 ITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHS 971 +T GK+DR ALPEP+ + EFRAP T E +A +F ++L DRVG DD FF+LGG+S Sbjct 1659 LTGSGKLDRKALPEPEFEA-REFRAPSTPVEEAVAAVFADVLDVDRVGRDDDFFELGGNS 1717 Query 972 LLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPR-LTRVDHDGPVRL 1030 LLAT++ A + A V VR +F+ +TV ALA + S AR + L + L Sbjct 1718 LLATQVCARLGAALDTTVPVRVLFDASTVEALAARVSA--STGARTKALVAAPRPDRIPL 1775 Query 1031 SSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGG 1090 S +Q R WF RF+ +AVNNIP A L G D + +AAI DV+ RHE LRTV+ ++ G Sbjct 1776 SLAQQRMWFLNRFEPESAVNNIPLAIRLSGDLDVESLSAAIGDVLERHESLRTVFPDVDG 1835 Query 1091 VPHQIIQPPAEVPVRCAAGSDAAWLRAELN----NERGYV--FDLETDWPIRAALLS-TP 1143 V +Q I+P +EV AG+ A E + ER V FDL TD P+R L + +P Sbjct 1836 VGYQSIRPASEV-----AGTVTAEAVTEADLPALVERMVVAGFDLTTDIPVRVGLFAVSP 1890 Query 1144 EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL- 1202 + VL LVVHHIA D +S G L D++TAY ARS G P+WAPL VQYADY++WQ +L Sbjct 1891 TEHVLVLVVHHIAADGFSMGPLTRDVMTAYAARSAGTLPAWAPLAVQYADYTLWQREVLG 1950 Query 1203 --DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAA 1260 DD + Q YW R L GL + L D PRPA+ G + A ++ +A Sbjct 1951 SEDDPESPMSTQVAYWKRTLAGLPDQLDLPTDRPRPAVAGYRGARHTVEVPADLQSAIAE 2010 Query 1261 VSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRND 1320 ++R GVT FM++ AA++V+L + G D+ IG PVAGR EA LD +IG F+N +VLR + Sbjct 2011 LARTRGVTPFMVMHAALSVLLARLSGTSDIAIGTPVAGRGEAVLDDVIGMFVNTLVLRTE 2070 Query 1321 LRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQ 1380 + + ++L RTR+ LAA+ H D+PF+++VE ++P RS +R+PLF +++ Q Sbjct 2071 VDAAGSFEDLLARTRETDLAAFGHADVPFERLVEILDPARSQARHPLFQVMLTF-----Q 2125 Query 1381 DHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVI---YRTELYERATAQR 1437 + + + G + +E A+ DL V G RG I Y TEL++ T + Sbjct 2126 NLGLTSFELGGLAVSDVEFDSTTAKFDLQVT-VTEGAPDRGLTIDLTYATELFDADTIRI 2184 Query 1438 FADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVG 1497 D +RV+ P + +++++ R ++ NA + +PVP Sbjct 2185 LGDRCLRVLSVVTATPSAVVGDIDLLDEVERSLVVGEWNATS------------RPVPDA 2232 Query 1498 VVGDVY 1503 + D++ Sbjct 2233 TLVDLF 2238 Score = 670 bits (1728), Expect = 0.0, Method: Compositional matrix adjust. Identities = 441/1092 (41%), Positives = 618/1092 (57%), Gaps = 66/1092 (6%) Query 441 LVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSP 500 L L +EQ RTPDA A+ + G TY DL+ +NRL LI G+G + V + + +S Sbjct 116 LASLFDEQVVRTPDAVALEFAGATLTYADLDARANRLARHLISLGVGPDSLVGLGIRRSL 175 Query 501 DLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDDP---- 556 +L+V +VK+G YVP+DP +P DRL ++L D +V+ T R+ +D P Sbjct 176 ELLVGMYAIVKAGGAYVPLDPDHPADRLGYVL-DIARPVVILTTTRDELTLDTDTPIVAV 234 Query 557 -------------TDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGE 603 TDADR PL +N AY+I+TSG+TG PKGVAV H + W + Sbjct 235 DALDLQAHSDTPVTDADRSAPLSAENLAYVIFTSGSTGRPKGVAVGHGAIVANLRWRQHM 294 Query 604 YDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAM 663 Y + D D +LQ +FDVS+ E F L GAR+V+ P G D YL ++ + G+T Sbjct 295 YPMTDADVVLQKTPFTFDVSVWEFFWPLQVGARLVVAAPDGHRDPAYLARIMAERGVTVA 354 Query 664 HFVPSLLGLFL-----------SLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLH 712 HFVPS+L +F+ + TL+ V GE LP + A +F A LH Sbjct 355 HFVPSMLSVFVASLASGAAGDPTQLSAEDVATLRNVFASGEALPPQTAARFRDISGAALH 414 Query 713 NFYGPTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGT 772 N YGPTE ++ + +V T VPIG +T +++LD+ L+ VP G GE+Y+ G Sbjct 415 NLYGPTEAAVDVTFHEVTADDET-TVPIGAAVADTALYVLDEGLRRVPAGTEGELYLAGV 473 Query 773 HVAYGYHRRAGLTAERFVADPFN-PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFR 831 +A GY +R LTA+RFVADP+ PG+RMYR+GDL + G++E++GR D QVK+RG R Sbjct 474 QLARGYLQRPDLTADRFVADPYGAPGARMYRTGDLVKLGRSGELEYIGRTDFQVKLRGLR 533 Query 832 IELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARV 891 IELG++ +A+ P V Q+VVVV LG LV YV G D VD + A V Sbjct 534 IELGEIESALLDHPAVSQSVVVVHADADLGDHLVAYVVTDGGAD------VDRHELAAAV 587 Query 892 AAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIAS-DTEFRAPQTATERRLAQLFG 950 +A LPEYM+P+ +V L E P+ A GK+DR ALP P +S +E+RAP T TE LA F Sbjct 588 SARLPEYMVPSLFVALAEFPLNASGKLDRKALPAPDFSSLASEYRAPTTPTEETLAATFA 647 Query 951 ELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTL 1010 E+LG +R+G DD +F LGG+SL AT++VA + G+ + VR+ F+ TV LA +D Sbjct 648 EVLGAERIGVDDDYFALGGNSLSATRVVARINADLGIRIDVRDFFDAPTVAQLAALVDAA 707 Query 1011 DSDSARPRLTRVDHDGP--VRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFA 1068 + R V + P + LS +Q R WF RFD +A NNI A L G D +A Sbjct 708 VAAGGDTRAPLVAQERPDTLPLSMAQQRMWFLNRFDTESAANNIVVAIRLTGALDVDALR 767 Query 1069 AAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAG----SDAAWLRAELNNERG 1124 A++DV+ RHE LRTV+ EI G Q+I P V V AA SD A A ++ Sbjct 768 EAVSDVIERHESLRTVFPEIDGAASQVILPADRVKVDLAAEPVRESDVADAVARTISQG- 826 Query 1125 YVFDLETDWPIRAALLS-TPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPS 1183 FD+ P+R LL+ TP + VL +VVHHI+ D +S L D++TAY ARS G PS Sbjct 827 --FDVTAAVPLRMRLLAVTPTEHVLVVVVHHISADGFSMNPLTRDIVTAYAARSAGAAPS 884 Query 1184 WAPLPVQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLS 1240 WAPL VQYADY++WQ +L DD ++ Q +W L L L D PRPA+ S Sbjct 885 WAPLAVQYADYALWQREVLGSEDDPESVIAQQMQFWRGALADLPDRLDLPADRPRPAVAS 944 Query 1241 GAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRS 1300 G + F +GA +L A++RD G + FM++ AA++V+L + G D+ IG PVAGR Sbjct 945 NNGASHRFSIGAETAARLDAIARDHGASTFMVVHAALSVLLARLSGTSDIAIGTPVAGRG 1004 Query 1301 EANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQR 1360 EA LD L+G F+N +VLR D+RG+ E+L R L A+ H D+PF+++VEA++P R Sbjct 1005 EAALDDLVGMFVNTLVLRADVRGDRPFTELLTGVRATDLEAFGHADVPFERLVEALSPAR 1064 Query 1361 SLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQA--DLSVNFFACGDE 1418 S SR+PLF + + + D + GD T+ ++ FDAA A DL+V A D Sbjct 1065 SQSRHPLFQVALSFQNMDRTDLAL-----GDLTVSGVD--FDAAVAKFDLAVT-VAESDS 1116 Query 1419 YRG----HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDR 1474 G + Y T+L++ +T + FAD VRV+EA A + +++++ A A R L Sbjct 1117 ATGALDVDLTYATDLFDASTMRVFADRFVRVLEAVAADASVVVGDIDVLDA-AERSALTA 1175 Query 1475 SNAGAGTARVYL 1486 ++ AG A + L Sbjct 1176 ASGDAGPAPMLL 1187 Score = 167 bits (422), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 155/571 (28%), Positives = 241/571 (43%), Gaps = 47/571 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQ-- 58 MWF+ +P NI ++ ++TG +D+ L A+ V RH LRT YP DG Q Sbjct 2832 MWFLNRLEPESTSYNIPLAMQLTGSLDVDALHAALRDVLARHESLRTFYPEDADGPHQVI 2891 Query 59 ---PTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAA 115 V DL P D D R L F++ PLR + R Sbjct 2892 APAADVEFDLTP--ISVDPADAYGRVSEL---------VGKGFDVRSAVPLRAGLFRLDD 2940 Query 116 DEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP--------------- 160 HV V HHI+ D S DL AY+ G P+ +P Sbjct 2941 TTHVFAFVVHHISADGVSMAPMARDLVTAYAARTQGE--APQWQPLPVQYADYALWQREV 2998 Query 161 -SAASGPDTTEA-DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARV 218 +A P T A L +W +A P+ L+LP S R A L A+ A + Sbjct 2999 LGSADEPGTVAAAQLAHWVRALAGAPDQLDLPTDRPRPAVASMRGAETEFTLSAELHAAL 3058 Query 219 ATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMR 277 ++A+ G + +MV +A L+ R + + D V PV RG A +D +G F NT+A+R Sbjct 3059 ESLARAEGVSLFMVAHSALAVLLARLSGTWDVTVGTPVAGRGEAALDDLVGMFVNTLALR 3118 Query 278 LRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPD 337 S+M F E++ ++ AFA+ + +RVV ++ DR + + F+ + Sbjct 3119 TELTSSMRFTEVVARAKEADLSAFANADLPFERVVEAVSSDRSSARHPVFQTVLSFQNQE 3178 Query 338 GGGFNPPGIECERYDLRSNITQLPLGF-MVEFDRAGVLVEAEHLVEILEPALAKQMLRHF 396 PG+ + L F ++ D V + ++ + A + F Sbjct 3179 QATLALPGLTVSSVPDTDRAAKFDLQFTLIPTDSGTVEAILTYATDLFDEATVVTLGERF 3238 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARL-----REVSRGERFDTPV---KTLVDLVNEQ 448 +L+ A P + + ++ E + A L E + +T V TL +++ Sbjct 3239 VRILEAVAADPHAVVGDIEIVTEAERALLPGFADSEPEEADASNTIVPATSTLPQVLSAV 3298 Query 449 TTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALG 508 P+A A+ +G TY +L+E S+RL LI +G+G RV V L +S D ++ A Sbjct 3299 VEADPEAPAIADDGTEITYGELDERSSRLARVLIAEGVGPGTRVPVALARSVDAVIAAWA 3358 Query 509 VVKSGAVYVPVDPSYPQDRLDFILADCDAKL 539 V+KSGA P+D + D + I A AKL Sbjct 3359 VLKSGAAVTPIDAN--DDAWESIDAALPAKL 3387 Score = 65.5 bits (158), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 33/73 (46%), Positives = 47/73 (65%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 ++++LD LKPVPVGV G++Y G ++R TA RFVA+PF+ G R+YR G+ Sbjct 2556 QLFVLDGRLKPVPVGVPGELYLAGVQLARGYVSRADLTADRFVANPFSGS-GERMYRTGD 2614 Query 1543 RGVWKADGQLELL 1555 W ADG+LE + Sbjct 2615 LVRWSADGELEYI 2627 Score = 58.5 bits (140), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/72 (44%), Positives = 43/72 (60%), Gaps = 1/72 (1%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 +Y+LD+ L+ VP G G++Y G L RP TA RFVADP+ A PG+R+YR G+ Sbjct 450 LYVLDEGLRRVPAGTEGELYLAGVQLARGYLQRPDLTADRFVADPYGA-PGARMYRTGDL 508 Query 1544 GVWKADGQLELL 1555 G+LE + Sbjct 509 VKLGRSGELEYI 520 Score = 53.9 bits (128), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/73 (47%), Positives = 46/73 (64%), Gaps = 5/73 (6%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFE 1632 T E +A + ADVL V VG DDFF LGG+S++ATQVAAR A D +P+ R++F+ Sbjct 2734 TAAEEVVAGVFADVLGVDRVGLDDDFFALGGNSLVATQVAARLGAALDAQVPV--RVLFD 2791 Query 1633 HPVLCELAAAVDA 1645 + LAA V + Sbjct 2792 ASTVQALAARVQS 2804 Score = 47.4 bits (111), Expect = 0.023, Method: Compositional matrix adjust. Identities = 28/64 (44%), Positives = 38/64 (60%), Gaps = 1/64 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR-DGGIPLTARMVFEHP 1634 T TE LAA A+VL +G DD+F LGG+S+ AT+V AR D GI + R F+ P Sbjct 636 TPTEETLAATFAEVLGAERIGVDDDYFALGGNSLSATRVVARINADLGIRIDVRDFFDAP 695 Query 1635 VLCE 1638 + + Sbjct 696 TVAQ 699 Score = 47.4 bits (111), Expect = 0.024, Method: Compositional matrix adjust. Identities = 38/74 (52%), Positives = 49/74 (67%), Gaps = 5/74 (6%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFE 1632 T E A+AA+ ADVL+V VGR DDFF LGG+S+LATQV AR A D +P+ R++F+ Sbjct 1685 TPVEEAVAAVFADVLDVDRVGRDDDFFELGGNSLLATQVCARLGAALDTTVPV--RVLFD 1742 Query 1633 HPVLCELAAAVDAK 1646 + LAA V A Sbjct 1743 ASTVEALAARVSAS 1756 >gi|344943005|ref|ZP_08782292.1| amino acid adenylation domain protein [Methylobacter tundripaludum SV96] gi|344260292|gb|EGW20564.1| amino acid adenylation domain protein [Methylobacter tundripaludum SV96] Length=7729 Score = 853 bits (2205), Expect = 0.0, Method: Compositional matrix adjust. Identities = 615/1723 (36%), Positives = 886/1723 (52%), Gaps = 118/1723 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + G+ NI ++ R++G +D A+ + RH LRT +P D AQ Sbjct 4589 LWFIHRLEGPGSNYNIPIALRLSGHLDADAFDSALLDLLARHEALRTRFPEFDGVAAQEI 4648 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCA--PFELSRDAPLRITVVRTAADEH 118 V + L R Q E+ Q + A +++ D P R + A + Sbjct 4649 VPV--------AEFGSLLTRCQVTEAELAVQLQQAADTALDITVDLPFRAWLFSLANEAQ 4700 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPS--AAS 164 VLL++ HHIA D S V DLT AYS + AD R S A Sbjct 4701 VLLMLVHHIAADGASMAVLADDLTLAYSSRCMQQTPRWTDLPIQYADYALWQRQSLGAVH 4760 Query 165 GPDTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 P + A L +W+ + P+ L LP + S+R + L A+ + +A+ Sbjct 4761 DPKSPMAQQLAFWQQALRGLPDELNLPADRPRPLVGSYRGGALPIHLSAELHRNLLALAQ 4820 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 + +M+L A AL+ R +D + AP+ R E IG+F N + +R Sbjct 4821 TEQASLFMLLQATLAALLSRLGAGEDIAIGAPIAGRTDQAIEGLIGFFVNALVLRTDLSG 4880 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 S R +L R A+AHQ + + +V L P R + +V + + Sbjct 4881 RPSLRTVLQRVRAFDLDAYAHQDLPFELLVDALQPTRSMARHPLFQVMLALQNTARPRMD 4940 Query 343 PPGIECE---------RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQML 393 PG+ ++DL ++ + + + + G+ E E ++ + + + ++ Sbjct 4941 LPGLSVAMEPLARTGAKFDLLVSLAE---QYDADGEPLGLWGELEFSSDLFDTSTIELLI 4997 Query 394 RHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTP 453 + + L++ A+A PD L AL+ + L E P TL L Q R P Sbjct 4998 QRWLRLIEQAVAEPDAPLYRCALVTPEERHALLEGFNATTRPIPDATLPALFEAQAARDP 5057 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 ATA+V+ + +Y +LN +NRL H L G+G V + +++S +++V L ++K+G Sbjct 5058 AATALVFADRELSYGELNAQANRLAHHLQTLGVGPNTLVGICVERSFEMLVGVLAILKAG 5117 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTPVRELAGYRSDD----------PTDADRIR 563 Y+P+DP YPQ+RL F+L D A VL T R LA S++ P AD R Sbjct 5118 GAYMPLDPEYPQERLHFMLDDA-AVSVLLTQQRLLAALPSNNAYVLCLDRDLPLFADGNR 5176 Query 564 PLRP-----DNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASP 618 P D+ AYLIYTSG+TG PKGVAV HR V V D + LQ+A Sbjct 5177 STPPSRAQADDLAYLIYTSGSTGQPKGVAVTHRNVVR-LVRSDDSLSFDSDEVFLQLAPL 5235 Query 619 SFDVSIAEIFGTLACGARMVIPRPG--GLTDIG-YLTALLRDEGITAMHFVPSLLGLFLS 675 +FD S E++ L G R+V+ PG L DIG +LT +T + L L + Sbjct 5236 AFDASTLELWAALLNGGRLVLMPPGQSTLEDIGRHLT----RHRVTTLWLTAGLFHLMVD 5291 Query 676 LPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDA-LLHNFYGPTETVINASRFKVVGPQG 734 + ++R+ GGE L K A A + N YGPTE S + V Sbjct 5292 -ERLEDLTGVRRLFAGGEALSVPHVQKAAAALGANRIINGYGPTENTTFTSCYPVPAADA 5350 Query 735 -TRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADP 793 T VPIG+P NT ++LD++LQPVP GV GE+Y GG +A Y R LTAERFVADP Sbjct 5351 ITTSVPIGKPIANTRTYILDEALQPVPVGVTGELYTGGLGLARAYLNRPALTAERFVADP 5410 Query 794 FN--PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAV 851 F+ PGSRMYR+GDLAR DG++EF+GRAD QVKIRGFRIE G++ +A+ P V Q Sbjct 5411 FSEAPGSRMYRTGDLARWREDGNLEFIGRADGQVKIRGFRIEPGEIESALLGLPQVMQTA 5470 Query 852 VVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIP 911 VV D LG LV Y P+ G D A+ +R ++ LP+YMLP+A+V L +P Sbjct 5471 VVARD-DGLGLQLVAYWVPSEGSDTSAEA------LRLALSEQLPDYMLPSAFVALAALP 5523 Query 912 ITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHS 971 +TA+GK+DR ALP P+ F +P + E LA LFGE+LG D+V DSFF LGGHS Sbjct 5524 LTANGKLDRRALPAPE-RGGYAFVSPSSPEEAPLAALFGEVLGLDQVSVADSFFALGGHS 5582 Query 972 LLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLS 1031 LLAT+LV+ VR V++ +R +FE TV LA + D SAR L + + LS Sbjct 5583 LLATRLVSRVREVMKVELPIRALFEAPTVAQLARRLR--DLRSARLPLKALPRPERLPLS 5640 Query 1032 SSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGV 1091 +Q R WF +R +GP+A NIP A L GP + +A A+ D++ RHE LRT + E GV Sbjct 5641 YAQQRLWFIHRMEGPSATYNIPIALRLTGPLNADALERALLDLLTRHEALRTRFPEFEGV 5700 Query 1092 PHQIIQPPAEVP---VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTV 1147 Q I P A++ RC A L A L D+ + P RA L E+ V Sbjct 5701 AAQQIVPVADIDSLLTRCELSE--AELSARLQQAADTALDISVELPFRAWLFCLGNEEQV 5758 Query 1148 LSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DD 1204 L ++VHHIA D S L DL AY AR Q P+W LP+QYADY++WQ L +D Sbjct 5759 LLILVHHIAADGSSMAALSDDLTLAYNARCLNQAPAWPNLPLQYADYALWQRQALGSVND 5818 Query 1205 GAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRD 1264 + Q +W R L GL E L D PRP + S G A+ L A + L A+++ Sbjct 5819 PLSSMAQQLAFWKRALRGLPDELSLPTDRPRPLVSSYCGGALPIHLSAELHRDLLALAQA 5878 Query 1265 LGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGN 1324 + FMLLQA +A +L + G G D+PIGAP+AGR++ ++ LIGFF+N +VLR DL G Sbjct 5879 EQASLFMLLQATLAALLSRLGAGEDIPIGAPIAGRTDKAIEGLIGFFVNTLVLRTDLSGR 5938 Query 1325 PTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVI 1384 P+LR VLQR R L AY HQDLPF+ +V+A+ P RS++R+PLF +++ ++ + + Sbjct 5939 PSLRTVLQRVRTFDLDAYGHQDLPFELLVDALQPTRSMARHPLFQVMLVLQ------NTV 5992 Query 1385 DTGPDGDTTLRVLEPTF-DAAQADLSVNFFAC-GDE-----YRGHVIYRTELYERATAQR 1437 + D +EP +A+ DLS N GD G + + ++L++ T +R Sbjct 5993 NARLDLPGINAAVEPLVRTSAKFDLSANLAELYGDNGEPLGVSGELEFSSDLFDAETVER 6052 Query 1438 FADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPVG 1497 + + ++E +PD PL + +++ + R +L+ + Y+LD+AL+PVPVG Sbjct 6053 LSRRWLSLIEQAVAQPDAPLHQCDILLPEERCMLLNN--------QTYVLDNALQPVPVG 6104 Query 1498 VVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGVWKADGQLELLAE 1557 VVG++Y A L P A R+VADPF+A PG R+YR G+ W DG LE + Sbjct 6105 VVGELYTSDIGYARAYLTNPVLCAERYVADPFSAVPGLRMYRTGDLVRWCKDGNLEFIGH 6164 Query 1558 IERLPTAQAAPVPAE---------PADTETERALAAILADVLEVGEVGRYDDFFNLGGDS 1608 ++ P +P E P+ T TE ALA I ++VL + ++ R D+FF LGG S Sbjct 6165 ADK-PVKSPGFMPIEAAEPKNDFIPSQTPTESALAEIWSEVLHLQQIDRRDNFFELGGHS 6223 Query 1609 ILATQVAAR-ARDGGIPLTARMVFEHPVLCELAAAVDAKPHVE 1650 +LATQV +R R+ GI + R +FE+P L LA +D + E Sbjct 6224 LLATQVVSRIQRNLGIVMPFRALFENPSLGALAGYLDRQCQTE 6266 Score = 770 bits (1989), Expect = 0.0, Method: Compositional matrix adjust. Identities = 551/1558 (36%), Positives = 806/1558 (52%), Gaps = 112/1558 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + G+ NI ++ R+TG +D L A+ + RH LRT +P D AQ Sbjct 912 LWFIHRLEGPGSTYNIPIALRLTGHLDADALDSALLDLLARHEALRTRFPEFDGIAAQEI 971 Query 61 VH-ADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 V AD+ T+ +T + L Q+ +++ D P R + +AA E V Sbjct 972 VPVADIAARLTRCQVT-------KAELAASLQQAAETALDITVDLPFRAWLFSSAAGEQV 1024 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGPD 167 LLL+ HHIA D S V DL+ AY+ L AD R + D Sbjct 1025 LLLLVHHIAADGASMAVLSNDLSSAYAARCLQQAPQWPDLPIQYADYALWQRQVLGAVDD 1084 Query 168 TTE---ADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 T L +W+ + P+ L LP + +S+R + L A+ + +A+ Sbjct 1085 PTSPMAQQLAFWQQALRGLPDELNLPTDRPRPLVSSYRGGALPIHLSAELHRDLLALAQA 1144 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSA 283 + +M+L A AL+ R +D + AP+ R E IG+F NT+ +R Sbjct 1145 EQASLFMLLQATLAALLSRLGAGEDIAIGAPIAGRTDQAIEGLIGFFINTLVLRTDLSRR 1204 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 S R LL R A+AHQ + + +V L P R + +V + + Sbjct 1205 PSLRTLLQRVRAFDLDAYAHQDLPFELLVDALQPTRSMARHPLFQVMLILQNTAKPRMDL 1264 Query 344 PGIECE---------RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLR 394 PG+ ++DL ++T+ F + G+ E E ++ + + + +++ Sbjct 1265 PGLTVSLEPLAHTGAKFDLTVDLTE---QFGENGEPLGLSGELEFSSDLFDASTIELLIQ 1321 Query 395 HFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPD 454 + L++ A+A PD L ++ + L E TP TL +L Q + P Sbjct 1322 RWLRLIEQAVAEPDAPLYRCDILTPDERHTLLEAFNPIALPTPAATLPELFEAQASSNPA 1381 Query 455 ATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGA 514 ATA+V+ +Y +LN +NRL H LIEQG G E + + LD+S +LI++ L V+KSGA Sbjct 1382 ATALVFADYELSYAELNARANRLAHALIEQGAGPESLIGLCLDRSFELIISLLAVLKSGA 1441 Query 515 VYVPVDPSYPQDRLDFILADCD------------------AKLVLRTP--VRELAGYRSD 554 Y+P+DP YP R++ +L D A+L+L P + +LA Sbjct 1442 AYLPLDPEYPMARIEAMLKDAAPLLVITATKMADILPESCARLLLDDPATLVDLAMKPRT 1501 Query 555 DPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQ 614 +PTD DR+ PL P + AY+I+TSG+TG PKG+A+ H ++ + K D DR L Sbjct 1502 NPTDTDRLMPLDPRHPAYVIFTSGSTGRPKGIAICHSALSAFLASIKSAVHCDAADRFLS 1561 Query 615 VASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPS-LLGLF 673 V + +FD+++ E+F L+ GA +++ DI T M PS L Sbjct 1562 VTTIAFDIAVLELFLPLSQGACVLLTARSESKDIPAFAQFFARHRPTLMQATPSHWRALL 1621 Query 674 LSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKV---- 729 +LP + LQ + GGEPLP ++A A +L+ N YGPTE + A++ + Sbjct 1622 EALPDIEP--QLQAI-CGGEPLPLDLAQALLAKTRSLV-NLYGPTEATVWATQQAITEST 1677 Query 730 VGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERF 789 + Q T +V IG P ++LLD +L+PVP GV GE+YI G +A GY R LTAERF Sbjct 1678 LALQRTPLVDIGTPLDRYRIYLLDATLEPVPVGVAGELYIAGAGLARGYLNRPALTAERF 1737 Query 790 VADPFNP--GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTV 847 VADPF+P G+RMYRSGDLAR DG++EF+GRAD QVKIRGFRIE G++ A + P V Sbjct 1738 VADPFSPMSGARMYRSGDLARWRDDGNLEFLGRADSQVKIRGFRIEPGEIEAVLLALPGV 1797 Query 848 GQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVL 907 QA VV D LG LV Y P+A + +R +AA LP+YMLP+A+VVL Sbjct 1798 AQAAVVARD-DGLGLQLVAYWVPSASS---DASDASAETLRPALAAQLPDYMLPSAFVVL 1853 Query 908 DEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDL 967 D +P+T +GK+DR ALP P+ F P + E LA LFGE+LG DRV DSFF L Sbjct 1854 DALPLTPNGKLDRRALPAPERGGAV-FVPPSSQEETLLAALFGEVLGLDRVSVADSFFAL 1912 Query 968 GGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGP 1027 GGHSLLAT+LV+ VR AF +++ +R +FE TV LAG + D SAR L + Sbjct 1913 GGHSLLATRLVSRVREAFALELPIRALFEAPTVAQLAGRLR--DLRSARLPLQALPRPER 1970 Query 1028 VRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYRE 1087 + LS +Q R WF +R +GP + NIP A L G D +AF +A+ D++ARHE LRT + E Sbjct 1971 LPLSYAQQRLWFIHRLEGPGSNYNIPIALRLSGHLDADAFDSALLDLLARHEALRTRFPE 2030 Query 1088 IGGVPHQIIQPPAEVP---VRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TP 1143 G+ Q I P +E+ RC A L +L D+ D P RA L S TP Sbjct 2031 FDGIAAQEIVPVSELTSLLTRCPVTE--AELAVQLQQAADTALDITVDLPFRAWLFSSTP 2088 Query 1144 --------EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYS 1195 E+ VL ++VHHIA D S VL DL AY +R Q P+W L +QYADY+ Sbjct 2089 LSTGSLANEEQVLLMLVHHIAADGASMAVLADDLTLAYSSRCMQQAPAWPDLTIQYADYA 2148 Query 1196 VWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGA 1252 +WQ L DD + + Q +W + L GL E L D PRP + S G A+ L A Sbjct 2149 LWQRQSLGAVDDPSSPMAQQLAFWQQALRGLPDELNLPTDRPRPLVSSYRGGALPIHLSA 2208 Query 1253 AIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFI 1312 + L A+++ + FMLLQA +A +L + G G D+ IGAP+AGR++ ++ LIGFF+ Sbjct 2209 ELHRNLLALAQTEQASLFMLLQATLAALLSRLGAGEDIAIGAPIAGRTDQAIEGLIGFFV 2268 Query 1313 NIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVV 1372 N +VLR DL G P+LR VLQR R L AYAHQDLPF+ +V+A+ P RS++R+PLF +++ Sbjct 2269 NALVLRTDLSGRPSLRTVLQRVRAFDLDAYAHQDLPFELLVDALQPTRSMARHPLFQVML 2328 Query 1373 HV------REQMP-----QDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRG 1421 + R +P + + TG D + + E +DA L + G Sbjct 2329 ALQNTARPRMDLPGLNVAMEPLARTGAKFDLLVSLAE-QYDADGEPLGL---------WG 2378 Query 1422 HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGA 1479 + + ++L++ T + + + ++E PD PL + +++ + R +L+ NA A Sbjct 2379 ELEFSSDLFDTDTVEHLSRRWLSLIEQAVAEPDAPLYQCALLTPEERHALLEGFNATA 2436 Score = 723 bits (1867), Expect = 0.0, Method: Compositional matrix adjust. Identities = 536/1560 (35%), Positives = 770/1560 (50%), Gaps = 156/1560 (10%) Query 8 DPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRP 67 D S L + + ++G+++ RLR+A A+ +RH +LRT + Q V P Sbjct 3542 DASPDLYTVQTAIDLSGNLEPERLRNACTALLKRHAVLRTGFVHQGQTPLQVVVPQPPLP 3601 Query 68 GWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHI 127 W DL+DL Q R + +A F + +R TV++ +H LL+ HH+ Sbjct 3602 -WQWLDLSDLEAVQQSQRAQAVAAELRTTRFAIDEPPLIRFTVLKLGQQQHRLLVTNHHL 3660 Query 128 AWDDGSWRVFFTDLTQAYS-------------RADLGADLGPEHRPSAASGPDTTEADLN 174 D S + +L Y+ D A L +H+P A + Sbjct 3661 VLDGWSMPILLRELFTLYNDFGSKNTLAPVSGYGDYLAWLQAQHKPQAHAA--------- 3711 Query 175 YWRAIMA--DPPEPL--ELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPY 230 W+A +A D P + + A P WR + P + + A+N G T Sbjct 3712 -WQAYLAGLDAPSLIAPDRSSQATIQAPHHWRYS-----FPEALSQGMNDFARNHGITLN 3765 Query 231 MVLLAAFGALVHRYTHSDDFLVAAPVLNRGA---GTEDAIGYFGNTVAMRLRPQSAMSFR 287 + A+ L+ R T D V R A G E +G NT+ +R+ S Sbjct 3766 TLFQGAWALLLSRLTGQRDVTFGITVSGRPAELPGVEHMVGLLINTLPLRISLPSDQPLA 3825 Query 288 ELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP---- 343 L A + +G + + L + R GGFNP Sbjct 3826 AWLGALQARQAGLLDYGYLGLTEIQR-----------------------IAGGFNPLFDT 3862 Query 344 ----PGIECERYDLRSNITQLPLGFMVEFDRA----GVLVEAEHLVEI---LEPAL---- 388 +R ++ I+ L + + D ++V +E+ +PAL Sbjct 3863 LLVFENYPIDRAAIKQGISDLKVTHIAGHDATHYPLSLMVAPGEQLELRLEFDPALFDDE 3922 Query 389 -AKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNE 447 +Q+ + L++ A+A PD L ++ + L E P TL +L Sbjct 3923 KGQQLGQRLVRLIEQAVAQPDAPLYRYDMLTPEERHTLLEGFNATAQPIPAATLPELFEM 3982 Query 448 QTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTAL 507 Q R P ATA+++ GQ +Y +LN +NRL H LI QG G E + + L++S +L+++ L Sbjct 3983 QAARDPAATALIFAGQELSYGELNSRANRLAHALIAQGAGPEALIGLCLERSFELVISLL 4042 Query 508 GVVKSGAVYVPVDPSYPQDRLDFILADCD------------------AKLVLRTPVRE-- 547 V+KSGA YVP+DP YP+ RL +L D A+L+L P + Sbjct 4043 AVLKSGAAYVPLDPEYPKARLQAMLEDAAPLLVITSTEMAAILPESCARLLLDDPSVQTG 4102 Query 548 LAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVD 607 LA +P++ADR+ PL P + AY+I+TSG+TG PKGV + + + W + Sbjct 4103 LAINPESNPSNADRLTPLSPLHPAYVIFTSGSTGRPKGVIMSQQALVNLLEWQTESSVLG 4162 Query 608 DTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVP 667 R LQ S +FDVS EIFG G+ +V+ + L LLR I + F+P Sbjct 4163 SKLRTLQFTSANFDVSFQEIFGAWKTGSTLVLVPDEVRREPEQLVDLLRSHAIERL-FIP 4221 Query 668 SLLGLFLSLPGVSQWRT-----LQRVPIGGEPLPGEVADKFHATFDAL----LHNFYGPT 718 + ++ + RT L+ V GE L +V FD + LHN YGP+ Sbjct 4222 --IAALNNIAELYANRTLSPLQLKEVICAGEQL--KVTPALRRFFDRIDHSQLHNHYGPS 4277 Query 719 ET-VINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYG 777 E+ V+ A + IG P NT ++LLD +L+PVP GV GE+YI G +A G Sbjct 4278 ESHVVTAFPLDQDSRHWQEMPSIGAPIRNTRIYLLDQTLEPVPVGVAGELYIAGAGLARG 4337 Query 778 YHRRAGLTAERFVADPFNP--GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 Y R LTAERFVADPF+P G+RMYRSGDLAR DG++EF+GRAD QVKIRGFRIE G Sbjct 4338 YLNRPALTAERFVADPFSPVVGARMYRSGDLARWRDDGNLEFLGRADSQVKIRGFRIEPG 4397 Query 836 DVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAAL 895 ++ A + P V QA VV D LG LV Y P+ D A+ +R +AA L Sbjct 4398 EIEALLLALPGVAQAAVVARD-DGLGLQLVAYWVPSVSSDASAET------LRPALAAQL 4450 Query 896 PEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGR 955 P+YMLP+A+V LD +P+T +GK+DR ALP P+ F P + E LA LFGE+LG Sbjct 4451 PDYMLPSAFVALDALPLTPNGKLDRRALPAPERGGAV-FVPPSSPEEALLAALFGEVLGL 4509 Query 956 DRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSA 1015 +RV DSFF LGGHSLLAT+LV+ VR AF +++ +R +FE TV LAG + D A Sbjct 4510 ERVSIADSFFALGGHSLLATRLVSRVREAFALELPIRALFEAPTVEQLAGRLR--DLRGA 4567 Query 1016 RPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVV 1075 R L + + LS +Q R WF +R +GP + NIP A L G D +AF +A+ D++ Sbjct 4568 RLPLQALPRPERLPLSYAQQRLWFIHRLEGPGSNYNIPIALRLSGHLDADAFDSALLDLL 4627 Query 1076 ARHEILRTVYREIGGVPHQIIQPPAE---VPVRCAAGSDAAWLRAELNNERGYVFDLETD 1132 ARHE LRT + E GV Q I P AE + RC A L +L D+ D Sbjct 4628 ARHEALRTRFPEFDGVAAQEIVPVAEFGSLLTRCQVTE--AELAVQLQQAADTALDITVD 4685 Query 1133 WPIRAALLS-TPEQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQY 1191 P RA L S E VL ++VHHIA D S VL DL AY +R Q P W LP+QY Sbjct 4686 LPFRAWLFSLANEAQVLLMLVHHIAADGASMAVLADDLTLAYSSRCMQQTPRWTDLPIQY 4745 Query 1192 ADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEF 1248 ADY++WQ L D + Q +W + L GL E L D PRP + S G A+ Sbjct 4746 ADYALWQRQSLGAVHDPKSPMAQQLAFWQQALRGLPDELNLPADRPRPLVGSYRGGALPI 4805 Query 1249 RLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLI 1308 L A + L A+++ + FMLLQA +A +L + G G D+ IGAP+AGR++ ++ LI Sbjct 4806 HLSAELHRNLLALAQTEQASLFMLLQATLAALLSRLGAGEDIAIGAPIAGRTDQAIEGLI 4865 Query 1309 GFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLF 1368 GFF+N +VLR DL G P+LR VLQR R L AYAHQDLPF+ +V+A+ P RS++R+PLF Sbjct 4866 GFFVNALVLRTDLSGRPSLRTVLQRVRAFDLDAYAHQDLPFELLVDALQPTRSMARHPLF 4925 Query 1369 DIVVHV------REQMP-----QDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGD 1417 +++ + R +P + + TG D + + E +DA L + Sbjct 4926 QVMLALQNTARPRMDLPGLSVAMEPLARTGAKFDLLVSLAE-QYDADGEPLGL------- 4977 Query 1418 EYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 G + + ++L++ +T + +R++E PD PL +V+ + R +L+ NA Sbjct 4978 --WGELEFSSDLFDTSTIELLIQRWLRLIEQAVAEPDAPLYRCALVTPEERHALLEGFNA 5035 Score = 525 bits (1352), Expect = 3e-146, Method: Compositional matrix adjust. Identities = 395/1234 (33%), Positives = 588/1234 (48%), Gaps = 92/1234 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + G+ NI ++ R++G +D A+ + RH LRT +P D AQ Sbjct 1980 LWFIHRLEGPGSNYNIPIALRLSGHLDADAFDSALLDLLARHEALRTRFPEFDGIAAQEI 2039 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCA--PFELSRDAPLR--------ITV 110 V +LT L R E+ Q + A +++ D P R ++ Sbjct 2040 VPVS--------ELTSLLTRCPVTEAELAVQLQQAADTALDITVDLPFRAWLFSSTPLST 2091 Query 111 VRTAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEH 158 A +E VLL++ HHIA D S V DLT AYS + AD Sbjct 2092 GSLANEEQVLLMLVHHIAADGASMAVLADDLTLAYSSRCMQQAPAWPDLTIQYADYALWQ 2151 Query 159 RPS--AASGPDTTEAD-LNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTA 215 R S A P + A L +W+ + P+ L LP + +S+R + L A+ Sbjct 2152 RQSLGAVDDPSSPMAQQLAFWQQALRGLPDELNLPTDRPRPLVSSYRGGALPIHLSAELH 2211 Query 216 ARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTV 274 + +A+ + +M+L A AL+ R +D + AP+ R E IG+F N + Sbjct 2212 RNLLALAQTEQASLFMLLQATLAALLSRLGAGEDIAIGAPIAGRTDQAIEGLIGFFVNAL 2271 Query 275 AMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFR 334 +R S R +L R A+AHQ + + +V L P R + +V + Sbjct 2272 VLRTDLSGRPSLRTVLQRVRAFDLDAYAHQDLPFELLVDALQPTRSMARHPLFQVMLALQ 2331 Query 335 EPDGGGFNPPGIECE---------RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILE 385 + PG+ ++DL ++ + + + + G+ E E ++ + Sbjct 2332 NTARPRMDLPGLNVAMEPLARTGAKFDLLVSLAE---QYDADGEPLGLWGELEFSSDLFD 2388 Query 386 PALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLV 445 + + R + L++ A+A PD L AL+ + L E P TL L Sbjct 2389 TDTVEHLSRRWLSLIEQAVAEPDAPLYQCALLTPEERHALLEGFNATARPIPDATLPALF 2448 Query 446 NEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVT 505 Q P ATA+V+ Q +Y +LN +NRL H LI QG G E + + LD+S +L+++ Sbjct 2449 EAQAASNPAATALVFGDQELSYGELNTRANRLAHALIAQGAGPESLIGLYLDRSFELVIS 2508 Query 506 ALGVVKSGAVYVPVDPSYPQDRLDFILAD-----------------CDAKLVLRTPVREL 548 L V+KSGA Y+P+DP +P R++ +L D D ++ + +L Sbjct 2509 LLAVLKSGAAYLPLDPEHPTARIEAMLEDATPLRVITTAALADNLPADCPRIVLDKLTDL 2568 Query 549 AGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDD 608 A + ++P+DADR+ PL P + AY+I+TSG+TG PKGV + H + + W + Y V Sbjct 2569 AQRQENNPSDADRLAPLTPLHPAYVIFTSGSTGKPKGVLIAHHALVNHMRWMQHAYPVVP 2628 Query 609 TDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPS 668 DR+L +P+FD S+ E++ L GA V+ L D L L + + FVPS Sbjct 2629 QDRVLGRTAPTFDASVWELWLPLLSGATQVLISTQQLHDAQLLFEQLDRQQVHVAQFVPS 2688 Query 669 LLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFK 728 LL FLS + + L++V GGE L E+ + + + N YGPTET I + + Sbjct 2689 LLASFLSEYDLKP-QALRQVFSGGEALSTELTRRLTEQWQVEVINLYGPTETTIQVTHYA 2747 Query 729 VV-GPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAE 787 PIG P NT ++LLD +L+PVP GV GE+YI G +A GY R LTAE Sbjct 2748 AQDNALNGSTTPIGAPIWNTRIYLLDQALEPVPVGVAGELYIAGAGLARGYLNRPALTAE 2807 Query 788 RFVADPFNP--GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDP 845 RFVADPF+P G+RMYRSGDLAR DG++EF+GRAD QVKIRGFRIE G++ A + P Sbjct 2808 RFVADPFSPLVGARMYRSGDLARWRDDGNLEFLGRADSQVKIRGFRIEPGEIEALLLALP 2867 Query 846 TVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYV 905 V QA V+ D LG LV Y P+A + A+ +R +AA LP+YMLP+A+V Sbjct 2868 GVAQAAVIARD-DGLGLQLVAYWVPSALSNASAET------LRPALAAQLPDYMLPSAFV 2920 Query 906 VLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFF 965 LD +P+T +GK+DR ALP P+ F P + E LA LFGE+LG +RV DDSFF Sbjct 2921 ALDALPLTPNGKLDRRALPAPE-RGGVLFVPPSSQEETLLAALFGEVLGLERVSVDDSFF 2979 Query 966 DLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHD 1025 LGG S+L+ +LV+ R A G+++ R+IFE TV LA + ++ L + Sbjct 2980 ALGGDSILSIQLVSRARRA-GLEIRPRDIFERPTVAGLASIARPVANNKP---LALFEAS 3035 Query 1026 GPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILR-TV 1084 GP + R +GP L + + A + + H +LR T Sbjct 3036 GPFTPTPIMARF---LAVEGPTKGFYQAMMIQLPAQIEADQLNAILQSTIDHHALLRATF 3092 Query 1085 YREIGGVPHQIIQPPAEVP---------VRCAAGSDAAWLRAELNNERGYVFDLETDWPI 1135 R G+ I+ PP V +R + E + D + Sbjct 3093 IRNEDGLWQGIVPPPGTVNACTRVQRIDLRAMDSAQRELRLHETVTQAAERLDPADGYLF 3152 Query 1136 RAALLSTPEQTVLSLVVHHIAGDHWSAGVLFTDL 1169 A S PE L ++HH+A D S +L +DL Sbjct 3153 EALWFSLPEGERLLWIIHHLAVDGVSWRILLSDL 3186 Score = 495 bits (1275), Expect = 2e-137, Method: Compositional matrix adjust. Identities = 359/1053 (35%), Positives = 534/1053 (51%), Gaps = 80/1053 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ SGA N+ + R+ G ++++ L +++ V RRH LRTT+ D+ QP Sbjct 6297 LWFIDQIG-SGAAYNMSSALRLRGQLNVSALEQSLSEVVRRHESLRTTF---DNSAEQPY 6352 Query 61 VHADLRPGWTQYDLTDLSQ-----RAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAA 115 H P +TDLS R Q R E AQ+E F+LSRD LR ++R Sbjct 6353 QHIR-APQPVALPVTDLSHLPDALRRQETRRE--AQQEAQKLFDLSRDLMLRTRLLRLDE 6409 Query 116 DEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTTEADLN- 174 DEHVLLL HHIA D S V +L + Y D +PSA + AD Sbjct 6410 DEHVLLLSLHHIAADGWSNDVLMRELAELYEA--FATD-----KPSALTELPVQYADFAV 6462 Query 175 ----------------YWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARV 218 +W+ + P L LP S+R ++L A A + Sbjct 6463 WQRQWLQGEVLQQQAAFWKKQLQGAPALLVLPTDRPRPPVESFRGGVYPVQLDAKRTAGL 6522 Query 219 ATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMR 277 ++++ T + LLAAF L+ RY+ DD +V +P+ NR TE IG+F NT+A+R Sbjct 6523 RKLSRDADTTLFTTLLAAFQVLLARYSGQDDIVVGSPIANRNCLETEPLIGFFVNTLALR 6582 Query 278 LRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPD 337 SF +L + A HQ + +R+V EL +R + ++ F + Sbjct 6583 ADLSGNPSFSRVLAQVKHTTLLAQDHQDLPFERLVEELQVERNLSYNPVVQIVFALQAAK 6642 Query 338 GGGFNPPGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFG 397 GF PG+E ++ ++ L + ++ + ++ + +++ HF Sbjct 6643 TTGFALPGLEVSSFEFAEPSVRMDLELHLWEQAEDIIGGCSYAADLFDETTIARLMAHFY 6702 Query 398 VLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVK-TLVDLVNEQTTRTPDAT 456 LLD +A P+ + GLAL+ E ++ ++ D P L L +Q RTPD Sbjct 6703 TLLDGIIADPERPIHGLALLGESESRQILVDWNRTAADLPKNLCLHQLFEQQAARTPDQA 6762 Query 457 AVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVY 516 A+V+ GQ +Y L++ +N+L H L G+ + V + +++S D++V L + K+G Y Sbjct 6763 AIVFAGQSLSYRQLDQRANQLAHHLQSLGVVPDSLVGICVERSADMVVGILAIHKAGGAY 6822 Query 517 VPVDPSYPQDRLDFILADCDAKLVL-------RTPVRELAGYRSDD--------PTDADR 561 +P+DP+YPQ+RL ++L D A ++L R P D PTD Sbjct 6823 LPLDPAYPQERLAYMLEDAAAPVLLTQAALLDRLPAHNAKPVYLDSDWPVIDALPTDQPS 6882 Query 562 IRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFD 621 + DN AY+IYTSG+TG PKGV V HR V ++ DR+LQ AS SFD Sbjct 6883 -NTVTADNLAYIIYTSGSTGNPKGVLVEHRGVCSIIQAQIALLEIGTHDRILQFASLSFD 6941 Query 622 VSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFL--SLPGV 679 + +EI L GA + + L L L D I+ PS L SLP + Sbjct 6942 AAASEIMMALGSGAALYLGTRETLAPGEPLRRFLTDNAISLATVTPSTLAALPEDSLPAL 7001 Query 680 SQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVP 739 RTL + GE E+ ++ + N YGPTE I A+ ++ T P Sbjct 7002 ---RTLG---VAGEACSAELFGQWAK--NRRFFNLYGPTEASICATAWRC--ETITANAP 7051 Query 740 -IGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNPGS 798 IGRP N +++LD QP P GV GE+YIGG VA GY R LT E+F+A+PF G Sbjct 7052 SIGRPLANVLVYILDALQQPAPIGVAGELYIGGVGVARGYLNRPELTEEKFIANPFGAG- 7110 Query 799 RMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVV-SDL 857 R+Y++GDL R DG+IE++GR D+QVKIRGFRIE G++ + + P V +AVV+ SD Sbjct 7111 RLYKTGDLTRWLPDGNIEYLGRIDQQVKIRGFRIEPGEIESVLTQHPAVREAVVLARSD- 7169 Query 858 PRLGK-SLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 916 + GK LV Y+ G + P +R + LP+YM+PAA+V L+ P+T +G Sbjct 7170 -QFGKPRLVAYLL-TDGQESPTGA------LREWLQGKLPDYMVPAAFVRLETWPLTPNG 7221 Query 917 KIDRAALPEPQI-ASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLAT 975 K+DR LPEP + A+D+E+ AP T TE LA+++ ++L +RVG D+FF+LGGHSLL T Sbjct 7222 KLDRQGLPEPDMQANDSEYLAPLTLTESALAEVWRKVLNVERVGRQDNFFELGGHSLLLT 7281 Query 976 KLVAAVRNAFGVDVGVREIFEFATVTALAGHID 1008 +L+ + A GV +R++F F T++A A H+D Sbjct 7282 QLIYHIEAALGVLPSMRDLFSFPTLSAQAAHLD 7314 Score = 306 bits (785), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 212/547 (39%), Positives = 302/547 (56%), Gaps = 16/547 (2%) Query 940 ATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFAT 999 + E LA LFGE+LG D V DDSFF LGG SLLAT+LV+ VR AF +++ + +F+ T Sbjct 817 SEEELLAALFGEVLGLDSVSVDDSFFALGGDSLLATQLVSRVREAFALELPTKMLFDAPT 876 Query 1000 VTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALH 1059 V L + D AR LT + + LS +Q R WF +R +GP + NIP A L Sbjct 877 VAQLLMCLR--DLRGARAPLTALPRPERLPLSYAQQRLWFIHRLEGPGSTYNIPIALRLT 934 Query 1060 GPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCA-AGSDAAWLRAE 1118 G D +A +A+ D++ARHE LRT + E G+ Q I P A++ R A L A Sbjct 935 GHLDADALDSALLDLLARHEALRTRFPEFDGIAAQEIVPVADIAARLTRCQVTKAELAAS 994 Query 1119 LNNERGYVFDLETDWPIRAALLSTPE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARS 1177 L D+ D P RA L S+ + VL L+VHHIA D S VL DL +AY AR Sbjct 995 LQQAAETALDITVDLPFRAWLFSSAAGEQVLLLLVHHIAADGASMAVLSNDLSSAYAARC 1054 Query 1178 TGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFP 1234 Q P W LP+QYADY++WQ +L DD + Q +W + L GL E L D P Sbjct 1055 LQQAPQWPDLPIQYADYALWQRQVLGAVDDPTSPMAQQLAFWQQALRGLPDELNLPTDRP 1114 Query 1235 RPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGA 1294 RP + S G A+ L A + L A+++ + FMLLQA +A +L + G G D+ IGA Sbjct 1115 RPLVSSYRGGALPIHLSAELHRDLLALAQAEQASLFMLLQATLAALLSRLGAGEDIAIGA 1174 Query 1295 PVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVE 1354 P+AGR++ ++ LIGFFIN +VLR DL P+LR +LQR R L AYAHQDLPF+ +V+ Sbjct 1175 PIAGRTDQAIEGLIGFFINTLVLRTDLSRRPSLRTLLQRVRAFDLDAYAHQDLPFELLVD 1234 Query 1355 AVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPT---FDAAQADLSVN 1411 A+ P RS++R+PLF +++ ++ + P +L L T FD DL+ Sbjct 1235 ALQPTRSMARHPLFQVMLILQNTAKPRMDL---PGLTVSLEPLAHTGAKFDLT-VDLTEQ 1290 Query 1412 FFACGDE--YRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARR 1469 F G+ G + + ++L++ +T + +R++E PD PL ++++ R Sbjct 1291 FGENGEPLGLSGELEFSSDLFDASTIELLIQRWLRLIEQAVAEPDAPLYRCDILTPDERH 1350 Query 1470 RILDRSN 1476 +L+ N Sbjct 1351 TLLEAFN 1357 Score = 254 bits (648), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 182/560 (33%), Positives = 284/560 (51%), Gaps = 31/560 (5%) Query 932 TEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGV 991 +F QT TE LA+++ E+L ++ D+FF+LGGHSLLAT++V+ ++ G+ + Sbjct 6184 NDFIPSQTPTESALAEIWSEVLHLQQIDRRDNFFELGGHSLLATQVVSRIQRNLGIVMPF 6243 Query 992 REIFEFATVTALAGHID----TLDSDS----ARPRLTRVDHDGPVRLSSSQMRSWFNYRF 1043 R +FE ++ ALAG++D T +DS P + V D P+ LS +Q R WF + Sbjct 6244 RALFENPSLGALAGYLDRQCQTETNDSMPLGVAPPILPVSRDQPLPLSFAQQRLWFIDQI 6303 Query 1044 DGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPPAEVP 1103 G A N+ A L G + +A ++++VV RHE LRT + P+Q I+ P V Sbjct 6304 -GSGAAYNMSSALRLRGQLNVSALEQSLSEVVRRHESLRTTFDNSAEQPYQHIRAPQPVA 6362 Query 1104 VRCAAGSDAAWL---------RAELNNERGYVFDLETDWPIRAALLSTPE-QTVLSLVVH 1153 + +D + L R E E +FDL D +R LL E + VL L +H Sbjct 6363 LPV---TDLSHLPDALRRQETRREAQQEAQKLFDLSRDLMLRTRLLRLDEDEHVLLLSLH 6419 Query 1154 HIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQR 1213 HIA D WS VL +L Y A +T + + LPVQYAD++VWQ L ++ Q Sbjct 6420 HIAADGWSNDVLMRELAELYEAFATDKPSALTELPVQYADFAVWQRQWLQ--GEVLQQQA 6477 Query 1214 DYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLL 1273 +W +QL G L D PRP + S G +L A L +SRD T F L Sbjct 6478 AFWKKQLQGAPALLVLPTDRPRPPVESFRGGVYPVQLDAKRTAGLRKLSRDADTTLFTTL 6537 Query 1274 QAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQR 1333 AA V+L + G D+ +G+P+A R+ + LIGFF+N + LR DL GNP+ VL + Sbjct 6538 LAAFQVLLARYSGQDDIVVGSPIANRNCLETEPLIGFFVNTLALRADLSGNPSFSRVLAQ 6597 Query 1334 TRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGD-T 1392 + L A HQDLPF+++VE + +R+LS NP+ IV ++ + P + + Sbjct 6598 VKHTTLLAQDHQDLPFERLVEELQVERNLSYNPVVQIVFALQAAKTTGFAL---PGLEVS 6654 Query 1393 TLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADR 1452 + EP+ + DL ++ + ++ G Y +L++ T R +++ Sbjct 6655 SFEFAEPS---VRMDLELHLWEQAEDIIGGCSYAADLFDETTIARLMAHFYTLLDGIIAD 6711 Query 1453 PDQPLREVEMVSAQARRRIL 1472 P++P+ + ++ R+IL Sbjct 6712 PERPIHGLALLGESESRQIL 6731 Score = 100 bits (250), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 127/490 (26%), Positives = 200/490 (41%), Gaps = 52/490 (10%) Query 1030 LSSSQMRSWFNYRFDGPNA-VNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREI 1088 LS Q F+ FD + + + A L G + A T ++ RH +LRT + Sbjct 3527 LSPLQEGLLFHALFDDASPDLYTVQTAIDLSGNLEPERLRNACTALLKRHAVLRTGFVHQ 3586 Query 1089 GGVPHQIIQPPAEVPVRCAAGSD---------AAWLRAELNNERGYVFDLETDWPIRAAL 1139 G P Q++ P +P + SD A + AEL R F ++ IR + Sbjct 3587 GQTPLQVVVPQPPLPWQWLDLSDLEAVQQSQRAQAVAAELRTTR---FAIDEPPLIRFTV 3643 Query 1140 LSTPEQTVLSLVV-HHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQ 1198 L +Q LV HH+ D WS +L +L T Y G + + AP+ Y DY W Sbjct 3644 LKLGQQQHRLLVTNHHLVLDGWSMPILLRELFTLYN--DFGSKNTLAPVS-GYGDYLAWL 3700 Query 1199 SALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKL 1258 A A W L GL + + PD A + A + A+ + Sbjct 3701 QAQHKPQAHAA------WQAYLAGLDAPSLIAPDRSSQATIQ-APHHWRYSFPEALSQGM 3753 Query 1259 AAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEA--NLDQLIGFFINIVV 1316 +R+ G+T L Q A A++L + G DV G V+GR ++ ++G IN + Sbjct 3754 NDFARNHGITLNTLFQGAWALLLSRLTGQRDVTFGITVSGRPAELPGVEHMVGLLINTLP 3813 Query 1317 LRNDLRGNPTLREVL--QRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHV 1374 LR L + L L + RQ L Y + L Q + NPLFD ++ V Sbjct 3814 LRISLPSDQPLAAWLGALQARQAGLLDYGYLGLTEIQRIAG-------GFNPLFDTLL-V 3865 Query 1375 REQMPQDHVIDTGPDGDTTLRVLEPT-FDAAQADLSVNFFACGDEYRGHVIYRTELYERA 1433 E P D G + L+V DA LS+ A G++ + + L++ Sbjct 3866 FENYPIDRAAIK--QGISDLKVTHIAGHDATHYPLSL-MVAPGEQLELRLEFDPALFDDE 3922 Query 1434 TAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKP 1493 Q+ LVR++E +PD PL +M++ + R +L+ NA A +P Sbjct 3923 KGQQLGQRLVRLIEQAVAQPDAPLYRYDMLTPEERHTLLEGFNATA------------QP 3970 Query 1494 VPVGVVGDVY 1503 +P + +++ Sbjct 3971 IPAATLPELF 3980 Score = 87.8 bits (216), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/141 (40%), Positives = 74/141 (53%), Gaps = 12/141 (8%) Query 1419 YRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAG 1478 + G TEL R T Q W V V+ + P + +V +AQ L+ S Sbjct 2708 FSGGEALSTELTRRLTEQ----WQVEVINLYG--PTETTIQVTHYAAQ--DNALNGSTTP 2759 Query 1479 AG----TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPG 1534 G R+YLLD AL+PVPVGV G++Y G L RP+ TA RFVADPF+ G Sbjct 2760 IGAPIWNTRIYLLDQALEPVPVGVAGELYIAGAGLARGYLNRPALTAERFVADPFSPLVG 2819 Query 1535 SRLYRNGERGVWKADGQLELL 1555 +R+YR+G+ W+ DG LE L Sbjct 2820 ARMYRSGDLARWRDDGNLEFL 2840 Score = 82.0 bits (201), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 38/73 (53%), Positives = 49/73 (68%), Gaps = 0/73 (0%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R+YLLD L+PVPVGV G++Y G L RP+ TA RFVADPF+ G+R+YR+G+ Sbjct 1696 RIYLLDATLEPVPVGVAGELYIAGAGLARGYLNRPALTAERFVADPFSPMSGARMYRSGD 1755 Query 1543 RGVWKADGQLELL 1555 W+ DG LE L Sbjct 1756 LARWRDDGNLEFL 1768 Score = 81.3 bits (199), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 38/73 (53%), Positives = 49/73 (68%), Gaps = 0/73 (0%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 R+YLLD L+PVPVGV G++Y G L RP+ TA RFVADPF+ G+R+YR+G+ Sbjct 4308 RIYLLDQTLEPVPVGVAGELYIAGAGLARGYLNRPALTAERFVADPFSPVVGARMYRSGD 4367 Query 1543 RGVWKADGQLELL 1555 W+ DG LE L Sbjct 4368 LARWRDDGNLEFL 4380 Score = 63.2 bits (152), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 31/77 (41%), Positives = 44/77 (58%), Gaps = 3/77 (3%) Query 1484 VYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGER 1543 VY+LD +P P+GV G++Y GG L RP T +F+A+PF A RLY+ G+ Sbjct 7062 VYILDALQQPAPIGVAGELYIGGVGVARGYLNRPELTEEKFIANPFGA---GRLYKTGDL 7118 Query 1544 GVWKADGQLELLAEIER 1560 W DG +E L I++ Sbjct 7119 TRWLPDGNIEYLGRIDQ 7135 Score = 57.8 bits (138), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/93 (38%), Positives = 51/93 (55%), Gaps = 2/93 (2%) Query 1561 LPTAQAAPVPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD 1620 LP + V P ++ E LAA+ +VL + V D FF LGGDSIL+ Q+ +RAR Sbjct 2938 LPAPERGGVLFVPPSSQEETLLAALFGEVLGLERVSVDDSFFALGGDSILSIQLVSRARR 2997 Query 1621 GGIPLTARMVFEHPVLCELAAAVDAKPHVEAEP 1653 G+ + R +FE P + LA+ A+P +P Sbjct 2998 AGLEIRPRDIFERPTVAGLASI--ARPVANNKP 3028 Score = 50.8 bits (120), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/62 (42%), Positives = 39/62 (63%), Gaps = 1/62 (1%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHPVLC 1637 E LAA+ +VL + V D FF LGGDS+LATQ+ +R R+ + L +M+F+ P + Sbjct 819 EELLAALFGEVLGLDSVSVDDSFFALGGDSLLATQLVSRVREAFALELPTKMLFDAPTVA 878 Query 1638 EL 1639 +L Sbjct 879 QL 880 Score = 50.1 bits (118), Expect = 0.004, Method: Compositional matrix adjust. Identities = 27/69 (40%), Positives = 41/69 (60%), Gaps = 1/69 (1%) Query 1573 PADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVF 1631 P ++ E LAA+ +VL + V D FF LGG S+LAT++ +R R+ + L R +F Sbjct 1881 PPSSQEETLLAALFGEVLGLDRVSVADSFFALGGHSLLATRLVSRVREAFALELPIRALF 1940 Query 1632 EHPVLCELA 1640 E P + +LA Sbjct 1941 EAPTVAQLA 1949 Score = 49.3 bits (116), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/71 (44%), Positives = 39/71 (55%), Gaps = 1/71 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T TE ALA + VL V VGR D+FF LGG S+L TQ+ G+ + R +F P Sbjct 7245 TLTESALAEVWRKVLNVERVGRQDNFFELGGHSLLLTQLIYHIEAALGVLPSMRDLFSFP 7304 Query 1635 VLCELAAAVDA 1645 L AA +DA Sbjct 7305 TLSAQAAHLDA 7315 Score = 47.0 bits (110), Expect = 0.031, Method: Compositional matrix adjust. Identities = 27/69 (40%), Positives = 40/69 (58%), Gaps = 1/69 (1%) Query 1573 PADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVF 1631 P + E LAA+ +VL + V D FF LGG S+LAT++ +R R+ + L R +F Sbjct 4490 PPSSPEEALLAALFGEVLGLERVSIADSFFALGGHSLLATRLVSRVREAFALELPIRALF 4549 Query 1632 EHPVLCELA 1640 E P + +LA Sbjct 4550 EAPTVEQLA 4558 >gi|226305326|ref|YP_002765284.1| non-ribosomal peptide synthetase [Rhodococcus erythropolis PR4] gi|226184441|dbj|BAH32545.1| putative non-ribosomal peptide synthetase [Rhodococcus erythropolis PR4] Length=9583 Score = 851 bits (2198), Expect = 0.0, Method: Compositional matrix adjust. Identities = 540/1525 (36%), Positives = 807/1525 (53%), Gaps = 79/1525 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D S A NI ++ R+ GD+D++ L A++ V RH LRT YP DG Q Sbjct 7978 MWFLNRFDGSAAAYNIPMALRLQGDLDVSALSAAISDVIGRHESLRTVYPEIGDGPVQV- 8036 Query 61 VHADLRP--GWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 ++P W+ ++ L E++A F+++R+ P+RI + + A+DE+ Sbjct 8037 ----VKPVSSWSD-EIVAEPTGVDELEGELVALA--STRFDVTREIPIRIRLFQLASDEY 8089 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGP 166 VL + HHI+ D S F D+ AY+ G AD R S Sbjct 8090 VLGVAIHHISADGSSMAPFARDVVTAYASRVAGYTPSWAPLDVQYADYSLWQREVLGSEE 8149 Query 167 DT---TEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D + YW +A P+ L LP S+R + A+ AR++ +A+ Sbjct 8150 DAGSIASQQIAYWSNALAGLPDQLALPADRPRPATQSFRGGYLHFDIDAELHARLSGLAR 8209 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGA-GTEDAIGYFGNTVAMRLRPQS 282 T +M+ AF L+ R + ++D V P+ RG +D IG F NT+ R + S Sbjct 8210 ANNSTLFMLTHTAFAMLLARLSGTEDIAVGTPIAGRGERALDDLIGMFVNTLVFRTQIDS 8269 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 F +LL R+ AFAH + +R+V LNP R + +V F F+ + GG Sbjct 8270 GAPFLDLLGRVRETDLQAFAHSDVPFERLVEVLNPPRSTARHPLYQVGFLFQNMETGGLE 8329 Query 343 PPGIECERYDLRSNITQLPLGFMVEFDR-------AGVLVEAEHLVEILEPALAKQMLRH 395 PG+ + D+ + + Q L +V DR AG+ + ++ + + + Sbjct 8330 LPGLTVKGVDIDNGVAQFDLQLIVS-DRYDANGSAAGITSMFSYAHDLFDESTVQDFADR 8388 Query 396 FGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPV--KTLVDLVNEQTTRTP 453 F LL + P T+ ALMD ++ R+ ++R D PV TLV+L +EQ P Sbjct 8389 FVRLLAEIASDPSLTVGDFALMDSSESDRI--LNRWNDTDHPVPGATLVELFDEQVGSNP 8446 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 A A+V TY + + NRL LI G+G E VA+ +++S +L+V VVK+G Sbjct 8447 GAVALVAGNTSLTYAEFDARVNRLARHLIATGVGPESLVALAIERSVELLVAMYAVVKAG 8506 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTPVR----------------ELAGYRSDDPT 557 YVP+DP++P DR++++L D VL T +LA Y T Sbjct 8507 GGYVPIDPNHPADRIEYVLTMADPVCVLTTSTTAKNPAFGDSVIEMDTIDLASYADAMVT 8566 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 D DR PLR DNTAY+I+TSG+TG PKGVA+ HR V +W + +Y +D +D ++ + Sbjct 8567 DGDRSAPLRADNTAYVIFTSGSTGRPKGVAISHRAVVNQILWKRDQYGLDRSDAMVLKTA 8626 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLP 677 +FD+S+ E + L GAR+VI P G D YL L+ E +T +H VPS+L + S Sbjct 8627 ATFDLSVWEFWSALTSGARLVIAEPEGHKDPSYLLDLMTREKVTTLHVVPSMLAMLQSAS 8686 Query 678 GVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRI 737 +L++V GE LP A +F DA L N YGPTE ++ + VVG T Sbjct 8687 ENGLPESLRQVLAIGEALPAATATEFAELSDAQLVNLYGPTEAAVSVTA-HVVGSDDTTS 8745 Query 738 VPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NP 796 VPIG P+ NT + +LD L PVP GV GE+Y+ G +A GYH RA LT+ERFVA+ F + Sbjct 8746 VPIGAPEWNTQVFVLDTRLHPVPVGVTGELYLAGAQLARGYHGRADLTSERFVANVFGDA 8805 Query 797 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 856 GSR+YR+GDL R +G++++V RAD QVKIRG+RIELG++ A + +V AVVV Sbjct 8806 GSRLYRTGDLVRWTQNGELDYVERADFQVKIRGYRIELGEIEALLRKQASVDSAVVVAKS 8865 Query 857 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 916 R G LVGYV P +G +D++ ++ + A LP YM+PAA +VLDE+P+ +G Sbjct 8866 DARTGDRLVGYVVPQSGE------SIDVETLKRTLVAELPSYMVPAALMVLDELPLNING 8919 Query 917 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 976 K+DR ALP+P+ + TEFRAP E +A +F ++LG RVG DD FF+LGG+SL+AT+ Sbjct 8920 KVDRKALPDPEFEA-TEFRAPTNPVEEIVAGVFADVLGVARVGLDDDFFELGGNSLVATQ 8978 Query 977 LVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMR 1036 +V+ + A + VR IFE +TV ALA + RP L + LS +Q R Sbjct 8979 VVSRLGEALDAQIPVRVIFEASTVGALASRVLEHAGSGGRPPLVAQVRPHEIPLSLAQQR 9038 Query 1037 SWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQII 1096 W +FD + NIP A L G D +A +A++D++ RHE+LRTVY + G P Q+I Sbjct 9039 MWVLNQFDKTSGAYNIPVAIRLSGALDVDALHSAVSDLIERHEVLRTVYPDQGNGPVQMI 9098 Query 1097 QPPAEVPVRCAA-GSDAAWLRAELNNERGYVFDLETDWPIRAALLSTPE-QTVLSLVVHH 1154 P + V +D A + ++ + FD+ T P+R L E + VL +V+HH Sbjct 9099 LPRSAATVGLEVIATDEASVAEQVADTVREGFDVTTAVPLRIRLFEVDESERVLVVVIHH 9158 Query 1155 IAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGP 1211 I+GD +S L D + AY AR+ G+ P WAPL VQYADY++WQ +L +D +G Sbjct 9159 ISGDGFSMAPLIRDTMVAYTARTGGETPEWAPLEVQYADYTLWQRDVLGSPEDADSQLGR 9218 Query 1212 QRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFM 1271 Q YW+ +L G L D PRPA S G EF + + D+LA ++R+ T FM Sbjct 9219 QLAYWVNELKGTPELLELPTDRPRPARASMRGAEFEFAVDSETTDRLATIAREQNSTVFM 9278 Query 1272 LLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVL 1331 ++ A+AV+L K G D+ IG P+AGR E LD L+G F+N +VLR ++ T ++L Sbjct 9279 VVHTALAVLLAKMSGSNDIAIGTPIAGRGERALDDLVGMFVNTLVLRTEIAPASTFVDLL 9338 Query 1332 QRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGD 1391 + + L+A+A+ D+PF+++V+ + +RS + +PLF +++ Q+ + T Sbjct 9339 GQVKDKDLSAFANADVPFERLVDELGRERSHAYSPLFQVMLTF-----QNMALGTFQLPG 9393 Query 1392 TTLRVLEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYERATAQRFADWLVRV 1445 L ++ FD A DL + D+ R Y T+L++ +T FA RV Sbjct 9394 LELSAVDSGFDQAMFDLQLTGIEQFDDAGVLSGLRMRFTYATDLFDESTIALFAARFGRV 9453 Query 1446 VEAFADRPDQPLREVEMVSAQARRR 1470 +E P +R +++V+ Q R Sbjct 9454 LEELVTDPGVVIRTIDIVTDQEREE 9478 Score = 822 bits (2122), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/1553 (36%), Positives = 811/1553 (53%), Gaps = 110/1553 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + A+ N+ V+ R+TG +DLA L AV+ V RH +LRT YP DG+ Sbjct 4279 MWFLNRFDTASAVNNVPVAVRLTGALDLAALNSAVHDVIGRHEVLRTVYP-EVDGIGYQK 4337 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 + L G DL ++R R++ F F+++ + P+R + + A D+ VL Sbjct 4338 I---LSAGDVSIDLG--AERVTDDRIQAELYSFFAQGFDVTVEVPMRAKMFQVADDDFVL 4392 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------AD--------LGPEHRP 160 V HHI+ D S D+ AY G AD LG E P Sbjct 4393 SFVVHHISTDGFSMSPLTRDVMTAYFARSQGQAPVWTPLPVQYADYALWQREVLGFEDDP 4452 Query 161 SAASGPDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVAT 220 + +NYW +AD PE L+LP + + A T + A A V Sbjct 4453 QS-----IIAQQINYWSDALADLPEQLDLPSDRTRPEIATGQGANHTFTIDAQLWADVEA 4507 Query 221 MAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLR 279 + TG TP+MV+ +A L+ R + + D + APV RG A +D IG F NT+ +R Sbjct 4508 TGQATGATPFMVVHSALAVLLARLSATTDIAIGAPVAGRGEAQLDDLIGMFVNTLVLRTE 4567 Query 280 PQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGG 339 +MSF +LL + R++ AFAH + +R+V L+P R + +V+ F+ Sbjct 4568 VDPSMSFTDLLASAREVDLQAFAHADVPFERIVEALDPVRSQAHHPLFQVALTFQNLGQS 4627 Query 340 GFNPPGIECERYDLRSNITQLPLGFMVE-FDRAGVLVEAEHLVEILEPALAKQMLRHFGV 398 PG+ + + + + L F +E AG+ + ++ + + A + F Sbjct 4628 ALELPGLTAAAVEFDAALAKFDLQFTLEDAADAGMSGTLTYATDLFDASTAAEFADRFVS 4687 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPV-----KTLVDLVNEQTTRTP 453 +L +A P + + ++ + R+ S DT V TL ++ R Sbjct 4688 VLRGVVANPTAAVGDVDVLTAGELDRVLSWS-----DTGVDRGVDSTLSAWFDDAAARFG 4742 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 D AV + G+ +Y +L+ +NRL LI QG G E VAV L +S DL+V L VVKSG Sbjct 4743 DRVAVRFGGESLSYGELSVRANRLARRLIAQGCGPESLVAVALPRSADLVVALLAVVKSG 4802 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTPVREL----------------AGYRSDDPT 557 A Y+PVDPSYP DR++F+LAD + REL + + T Sbjct 4803 AGYLPVDPSYPADRVEFMLADAAPVAAISWSGRELVLPAGLPVVDIDAVDVSEFDGSVVT 4862 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 DADR+ PLR N AY+IYTSG+TG PKGV VPH VA+ F + Y D++D S Sbjct 4863 DADRVAPLRSSNVAYVIYTSGSTGRPKGVQVPHFTVAKLFANTESVYGFDESDVWTMFHS 4922 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA--------LLRDEGITAMHFVPSL 669 +FD S+ E++G L G +V+ + Y+T+ LL E +T ++ PS Sbjct 4923 YAFDFSVWELWGPLLYGGTLVV--------VDYVTSRSPEQFLELLAAERVTVLNQTPSA 4974 Query 670 L------GLFLSLPGVSQWRTLQRVPIGGEPLP-GEVADKFHATFDA--LLHNFYGPTET 720 S G + +L+ V GGE L ++D + D+ L N YG TET Sbjct 4975 FYQLAEADRLASESGQAAELSLRWVVFGGEALELRRLSDWYGRRGDSAPTLVNMYGITET 5034 Query 721 VINASR--FKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGY 778 ++ S +G+ + +LD L PVP GV GE+Y+ G +A GY Sbjct 5035 TVHVSHRVLDAAMAADASASVVGQAISGLQVFVLDTRLAPVPVGVAGEMYVSGVQLARGY 5094 Query 779 HRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVA 838 +AGLT+ RFVA PF G +YR+GD+A N+ GD+E++GRAD+QVKIRGFRIE+G++ Sbjct 5095 LGQAGLTSTRFVASPFTAGEVLYRTGDVASWNSAGDLEYLGRADDQVKIRGFRIEIGEIE 5154 Query 839 AAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEY 898 +A+ D +V Q VVV + + LV YV AAG V V +D +R V + LPEY Sbjct 5155 SAVLADVSVAQTAVVVREDSPGDQRLVAYVVSAAG------VSVSVDDLRVSVGSLLPEY 5208 Query 899 MLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRV 958 M+P+A+VVLD IP+T +GK+DR ALP P + FRAP + E +AQ F ++LG +RV Sbjct 5209 MVPSAFVVLDSIPLTVNGKLDRRALPVPSLQVAV-FRAPTSVVEEVVAQTFADVLGVERV 5267 Query 959 GADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPR 1018 G DD FF LGG+SL+AT++ + + A V VRE+FE +TV LA + + +R Sbjct 5268 GLDDDFFALGGNSLIATQVTSRLGQALDASVSVRELFEASTVEGLAARLGSRVGGGSRAA 5327 Query 1019 LTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARH 1078 LT V LS +Q R WF + D +A NN+P A L G D + A++DVV RH Sbjct 5328 LTAQVRPAQVPLSLAQQRMWFLNQLDTNSAGNNVPVAITLTGKLDVSGLEQAVSDVVGRH 5387 Query 1079 EILRTVYREIGGVPHQIIQPPAEVPVRCAAG--SDAAWLRAELNNERGYVFDLETDWPIR 1136 E+LRTVY E+ G+ +Q I PA+V V AA SD+ + +E+ N FD+ T+ P+R Sbjct 5388 EVLRTVYPEVDGIGYQKIVAPADVGVNLAATLVSDSE-IVSEVTNFVATGFDVTTEVPLR 5446 Query 1137 AALLSTP-EQTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYS 1195 A L T ++ VL VVHHI+ D +S G L D++TAY AR+ GQ P+W PLPVQYADY+ Sbjct 5447 ARLFQTKADEHVLVFVVHHISTDGFSMGPLTRDIMTAYYARTNGQAPTWTPLPVQYADYA 5506 Query 1196 VWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGA 1252 +WQ +L DD I+ Q YW + L G+ + L D RPA+ SG G EF +G Sbjct 5507 LWQREVLGSEDDPQSIIAQQITYWAQALDGVPEQLNLPGDRARPAVFSGQGATFEFSIGQ 5566 Query 1253 AIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFI 1312 + ++L V R+ + FM++ +A+A +L + G D+ IGAP+AGR E+ LD LIG F+ Sbjct 5567 ELHERLIGVGREHNASMFMVVHSALASLLARLSGTTDITIGAPMAGRGESELDDLIGMFV 5626 Query 1313 NIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVV 1372 N +VLR ++ + +L R+ L A+AH DLPF+++VE ++P RS + +PLF + + Sbjct 5627 NTLVLRTEVDPSAPFTTLLSSARETDLQAFAHSDLPFERLVEVLDPVRSRAHHPLFQVAL 5686 Query 1373 HVREQMPQDHVIDTGPDGDTTLRVLEPTFD--AAQADLSVNFFACGDEYRGHVIYRTELY 1430 + + Q+ + G L E D A+ DL + + Y T+L+ Sbjct 5687 AF-QNLGQNSLALPG------LTAAEFAIDETVAKFDLQLTISEVSEGLSATFTYATDLF 5739 Query 1431 ERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTAR 1483 + +T + FA L+R++ A P + ++E++ + + R +L A +G A+ Sbjct 5740 DESTVRGFAARLMRILNGIATDPATSVGDIEILDS-SEREVLTSQRASSGVAQ 5791 Score = 764 bits (1973), Expect = 0.0, Method: Compositional matrix adjust. Identities = 544/1555 (35%), Positives = 795/1555 (52%), Gaps = 117/1555 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYP-VGDDGVAQP 59 MWF+ +P+ A+ N+ + RI+G +D+A L AV V RH LRT YP V G Sbjct 3207 MWFLNRFEPASAVNNVPAAIRISGALDVAALDAAVIDVVGRHESLRTVYPDVDGVGYQDV 3266 Query 60 TVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 D+ + +T+ A L + F+++ + PLR + + E+V Sbjct 3267 LDVQDVVVDLSPVSITEDRLAAGIAELATVG-------FDVTSEVPLRAKLFKVGDSEYV 3319 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAY---SRADL---------GADLGPEHRPSAASGPD 167 L+ V HHI+ D S D+ AY +RA + AD R S D Sbjct 3320 LVFVVHHISTDGFSMGPLTRDVMVAYEARTRASVPAWTPLPVQYADYSLWQREVLGSEDD 3379 Query 168 ---TTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 + +W +AD PE L+LP S R A + A V ++A + Sbjct 3380 PRSVIAKQIAFWSDALADLPEQLDLPADRPRPEVASGRGAEVEFDIDATLHEAVNSIAHS 3439 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSA 283 + TP+MV+ AA ++ R + + D + P+ RG A +D IG F NT+ +R + Sbjct 3440 SNSTPFMVVHAALTVVLSRLSATTDIAIGTPIAGRGEAQLDDLIGMFVNTLVLRTEVDPS 3499 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 MSF +LL + R++ AFAH + +RVV L+P R + +V+ F+ + Sbjct 3500 MSFTDLLASAREVDLQAFAHADVPFERVVEVLDPVRSQARHPLFQVALTFQNHEQTTLEL 3559 Query 344 PGIECE---------RYDLRSNITQ------LPLGFMVEFDRAGVLVEAEHLVEILEPAL 388 +E ++DL+ +T+ P G A L + +VE Sbjct 3560 GDLEVSIESADLALAKFDLQLTLTERTDEAGAPAGMSASLTYATDLFDESTVVE-----F 3614 Query 389 AKQMLRHF-GVLLDNALAAPDNTLSGLALMD-ERDAARLREVSRGERFDTPVKTLVDLVN 446 +++R F V D +A D + L+D ER+ L S G+ TL + Sbjct 3615 GDRLVRTFRAVTADPTVAVGDVDI----LVDGERNL--LSRFSAGQIDRGVDSTLSAWFD 3668 Query 447 EQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTA 506 + R D AV + G+ TY +L+ SNRL LI QG G E VAV L +S DL+V Sbjct 3669 DAAARFGDRIAVRFGGESLTYAELSVRSNRLARRLIAQGCGPESLVAVALPRSADLVVAL 3728 Query 507 LGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRTPVREL----------------AG 550 L VVKSGA Y+PVDPSYP DR++F+LAD + REL + Sbjct 3729 LAVVKSGAGYLPVDPSYPADRVEFMLADAAPVAAISWSGRELVLPAGLPVVDIDAVDVSE 3788 Query 551 YRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTD 610 + TDADR+ PLR N AY+IYTSG+TG PKGV VPH VA+ F + Y D++D Sbjct 3789 FDGSVVTDADRVAPLRSSNVAYVIYTSGSTGRPKGVQVPHFTVAKLFANTESVYGFDESD 3848 Query 611 RLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTA--------LLRDEGITA 662 S +FD S+ E++G L G +V+ + Y+T+ LL E +T Sbjct 3849 VWTMFHSYAFDFSVWELWGPLLYGGTLVV--------VDYVTSRSPEQFLELLAAERVTV 3900 Query 663 MHFVPSLL------GLFLSLPGVSQWRTLQRVPIGGEPLP-GEVADKFHATFDA--LLHN 713 ++ PS S G + +L+ V GGE L ++D + D+ L N Sbjct 3901 LNQTPSAFYQLAEADRLASESGQAAELSLRWVVFGGEALELRRLSDWYGRRGDSAPTLVN 3960 Query 714 FYGPTETVINASR--FKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGG 771 YG TET ++ S +G+ + +LD L PVP GV GE+Y+ G Sbjct 3961 MYGITETTVHVSHRVLDAAMAADASASVVGQAISGLQVFVLDTRLAPVPVGVAGEMYVSG 4020 Query 772 THVAYGYHRRAGLTAERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFR 831 +A GY +AGLT+ RFVA PF G +YR+GD+A N+ GD+E++GRAD+QVKIRGFR Sbjct 4021 VQLARGYLGQAGLTSTRFVASPFAAGEVLYRTGDVASWNSAGDLEYLGRADDQVKIRGFR 4080 Query 832 IELGDVAAAIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARV 891 IE+G++ +A+ D +V Q VVV + + LV YV AAG V V +D +R V Sbjct 4081 IEIGEIESAVLADVSVAQTAVVVREDSPGDQRLVAYVVSAAG------VSVSVDDLRVSV 4134 Query 892 AAALPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGE 951 + LPEYM+P+A+VVLD IP+T +GK+DR ALP P + FRAP + E +AQ F + Sbjct 4135 GSLLPEYMVPSAFVVLDSIPLTVNGKLDRRALPVPSLQVAV-FRAPTSVVEEVVAQTFAD 4193 Query 952 LLGRDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLD 1011 +LG +RVG DD FF LGG+SL+AT++ + + A V VRE+FE +TV LA + + Sbjct 4194 VLGVERVGLDDDFFALGGNSLIATQVTSRLGQALDASVSVRELFEASTVEGLAARLGSRV 4253 Query 1012 SDSARPRLTRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAI 1071 +R LT V LS +Q R WF RFD +AVNN+P A L G D A +A+ Sbjct 4254 GGGSRAALTAQVRPAQVPLSLAQQRMWFLNRFDTASAVNNVPVAVRLTGALDLAALNSAV 4313 Query 1072 TDVVARHEILRTVYREIGGVPHQIIQPPAEVPVRCAAGSDA-AWLRAELNNERGYVFDLE 1130 DV+ RHE+LRTVY E+ G+ +Q I +V + A ++AEL + FD+ Sbjct 4314 HDVIGRHEVLRTVYPEVDGIGYQKILSAGDVSIDLGAERVTDDRIQAELYSFFAQGFDVT 4373 Query 1131 TDWPIRAALLSTPEQT-VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + P+RA + + VLS VVHHI+ D +S L D++TAY ARS GQ P W PLPV Sbjct 4374 VEVPMRAKMFQVADDDFVLSFVVHHISTDGFSMSPLTRDVMTAYFARSQGQAPVWTPLPV 4433 Query 1190 QYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV 1246 QYADY++WQ +L DD I+ Q +YW L L + L D RP + +G G Sbjct 4434 QYADYALWQREVLGFEDDPQSIIAQQINYWSDALADLPEQLDLPSDRTRPEIATGQGANH 4493 Query 1247 EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQ 1306 F + A + + A + G T FM++ +A+AV+L + D+ IGAPVAGR EA LD Sbjct 4494 TFTIDAQLWADVEATGQATGATPFMVVHSALAVLLARLSATTDIAIGAPVAGRGEAQLDD 4553 Query 1307 LIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNP 1366 LIG F+N +VLR ++ + + ++L R++ L A+AH D+PF+++VEA++P RS + +P Sbjct 4554 LIGMFVNTLVLRTEVDPSMSFTDLLASAREVDLQAFAHADVPFERIVEALDPVRSQAHHP 4613 Query 1367 LFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFF---ACGDEYRGHV 1423 LF + + + + Q + G L FDAA A + F A G + Sbjct 4614 LFQVALTF-QNLGQSALELPG------LTAAAVEFDAALAKFDLQFTLEDAADAGMSGTL 4666 Query 1424 IYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAG 1478 Y T+L++ +TA FAD V V+ P + +V++++A R+L S+ G Sbjct 4667 TYATDLFDASTAAEFADRFVSVLRGVVANPTAAVGDVDVLTAGELDRVLSWSDTG 4721 Score = 727 bits (1876), Expect = 0.0, Method: Compositional matrix adjust. Identities = 526/1552 (34%), Positives = 780/1552 (51%), Gaps = 128/1552 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ DPS N+ + R+TG +D + L AV + RH LRT YP DG AQ Sbjct 1087 MWFINRLDPSTPAYNLPFTVRLTGSVDPSALHAAVMDLLERHESLRTIYP-DVDGTAQQL 1145 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEV--LAQREFCAPFELSRDAPLRITVVRTAADEH 118 V L +L + R L + +A R F E+ P+R+ + + ++ Sbjct 1146 V---LPVDRAAVELNPVKIRNSHLDAALFDVASRGFDVTLEI----PVRVALFEVSPTDY 1198 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYS-RADLGA-----------DLGPEHRPSAASGP 166 VL++V HHIA D S+R DL AYS R++ A D R + S Sbjct 1199 VLVMVLHHIAADGLSFRPLARDLLVAYSARSEKSAPAWTPLPIQYADYALWQREALGSDE 1258 Query 167 D---TTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 D + +N+WR +AD P+ L+LP S A+ ++ T ++ +A+ Sbjct 1259 DPRSESSRQINFWRRALADLPDQLDLPTDRPRPAIASNHGAKHHFQISERTTRKLNELAR 1318 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 + + +MVL AA+ L+ R + + D + AP+ RG D IG F NT+ +R Sbjct 1319 SRSVSLFMVLQAAYATLLSRLSGTSDIAIGAPIGGRGDQALNDVIGMFVNTLVLRTEVDP 1378 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSF-----GFREPD 337 F ELL R+ A+ H + +R+V L+P R + +V+ G RE + Sbjct 1379 NERFEELLARVRESGLSAYGHADVPFERLVEVLSPARSQARHPLFQVALTAEISGRRELE 1438 Query 338 GGGFNPPGIECE----RYDLRSNITQLPLGFMVEFDRAGVLVEA-EHLVEILEPALAKQM 392 G E E ++DL +++ P G + A VL + ++ +PA Sbjct 1439 FSGVKAVAAELEVPVAKFDLELMVSENPEGT----EDADVLSATFTYATDLFDPATVNTF 1494 Query 393 LRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRT 452 F +LD P+ + + L+ + L V+ + P ++LVD+ T Sbjct 1495 ATRFVRILDAVATRPETIVGDIDLLSRSERTDLTVVA--ADYTMPRQSLVDIFLSGTAEA 1552 Query 453 PDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKS 512 D+ AV +EG+ TY +L+E S++L LI +G G E VA+ +S +++ V KS Sbjct 1553 -DSVAVRFEGRSITYRELDEQSSKLARVLIGRGAGPETIVALAFPRSYEMVCAVWAVAKS 1611 Query 513 GAVYVPVDPSYPQDRLDFILADCDA-------KLVLRTPVR-------------ELAGYR 552 GA YVPVDPSYP+DR+ +LAD A + V + P EL+ Sbjct 1612 GAAYVPVDPSYPEDRVRHMLADSSAAIGLTSGQFVDKLPAVTEWLVLDGQALNGELSTQS 1671 Query 553 SDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRL 612 S TD DRI P+ + AY+IYTSG+TG PKGV+V H + + Y+V+ + R Sbjct 1672 SAPVTDEDRIAPIHSSHVAYVIYTSGSTGKPKGVSVTHGGLRGVRDAAQRRYEVEQSSRF 1731 Query 613 LQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGL 672 L + SPSFD S+ E + GA +VI P + L+ LL E +T P++LG Sbjct 1732 LHICSPSFDPSVLEWMVAFSAGATLVIV-PSTIIGGHELSDLLHSEKVTHAIITPAVLGT 1790 Query 673 F--LSLPGVSQWRTLQRVPIGGEPLPGEVADKF---HATFDALLHNFYGPTETVINASRF 727 LP L+ V +GG+ E+ K+ A F N YGPTET I +S Sbjct 1791 MEPAELP------ELRVVSVGGDVTTPELLAKWAPGRAYF-----NGYGPTETTIISSFG 1839 Query 728 KV-VGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTA 786 + +G R + IGRP + +LD+ L PVP G GE+Y G +A GYH R GL+A Sbjct 1840 DLAIG----RSIDIGRPVEGMSALVLDERLHPVPVGTRGELYFAGAALARGYHERRGLSA 1895 Query 787 ERFVADPFNP-GSRMYRSGDLAR------RNADGDIEFVGRADEQVKIRGFRIELGDVAA 839 ERFVA+P++P G RMYR+GD+ R R G +E+VGR+D QVK+RGFRIELG++ A Sbjct 1896 ERFVANPYSPDGERMYRTGDVVRWTGGDARGDAGVLEYVGRSDFQVKVRGFRIELGEIDA 1955 Query 840 AIAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYM 899 ++ +V AV V S+ +LV YV A G D D + + VA ALP YM Sbjct 1956 VLSSHESVRFAVTVGSEGAAGVTTLVSYVELADGS------SFDRDVLASFVAEALPSYM 2009 Query 900 LPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVG 959 +P+ + L E+P+T GK+DR ALPEP + EFRAP T E +AQ+ ++LG +RVG Sbjct 2010 VPSVIMELAEVPLTPVGKLDRRALPEP-VFEVREFRAPTTPVEEIVAQVIADVLGVERVG 2068 Query 960 ADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRL 1019 DD FF+LGG+SL+AT++ + + A V VR +F+ +TV ALA HI++ + L Sbjct 2069 LDDDFFELGGNSLVATQVTSRLGRALDTTVPVRTLFDVSTVEALAAHIESHVGSGGQKAL 2128 Query 1020 TRVDHDGPVRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHE 1079 + LS +Q R WF RFD +A NI FA L G DT A A+ DV+ARHE Sbjct 2129 VAQVRPAEIPLSLAQQRMWFLNRFDTDSAAYNITFALHLTGHLDTAAMEMALEDVLARHE 2188 Query 1080 ILRTVYREIGGVPHQIIQPPAEV--PVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRA 1137 +LRTVY + P Q I +E + + SD L + + D+ D PIR Sbjct 2189 VLRTVYPDGASGPKQSILSLSEAFGGLTVESVSDQDELESRVAAIGSSAIDVTVDVPIRV 2248 Query 1138 ALLSTPE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSV 1196 LL+ + + L++VVHHIA D WS L D++ AY AR G P+W PL VQYADYS+ Sbjct 2249 RLLTVSDTEHTLAIVVHHIAADGWSMAPLARDVMIAYSARKDGIAPAWQPLTVQYADYSL 2308 Query 1197 WQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAA 1253 WQ +L DD ++ Q YW L L L D RP + S G+ F + Sbjct 2309 WQREVLGSEDDSESLISQQISYWTETLADLPDVIELPSDRSRPDVASMRGERFAFEISGD 2368 Query 1254 IRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFIN 1313 + +L A++R+ T FM L +A+AV++ + G D+ +G PVAGR + LD L+G F+N Sbjct 2369 VHRRLDALARENNATLFMALHSALAVLMARLSGTSDIAVGTPVAGRGDEALDDLVGMFVN 2428 Query 1314 IVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVH 1373 +VLR ++ ++L AL A+AH D+PF+++V+ + P RS +R+PLF +V+ Sbjct 2429 TLVLRTEVDQAQAFTDLLAAASDSALGAFAHSDVPFERLVDVLAPARSQARHPLFQVVLS 2488 Query 1374 VRE------QMP-----QDHVIDTGPDGDTTLRVLEPT-FDAAQADLSVNFFACGDEYRG 1421 ++ ++P + T D L V E D Q LS F Sbjct 2489 LQNLAQTALELPGLAIKAAEIDTTTAKFDLELAVTESIGEDGIQQGLSAEF--------- 2539 Query 1422 HVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILD 1473 + +L++ +T + FA LVR++E P + +++++ A R + D Sbjct 2540 --TFAADLFDVSTVEGFARRLVRILETVVSVPSIVVGDIDILGATERGVLAD 2589 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 513/1546 (34%), Positives = 754/1546 (49%), Gaps = 106/1546 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D A NI + +TG +D A + A+ V RH +LRT YP G G Q Sbjct 2146 MWFLNRFDTDSAAYNITFALHLTGHLDTAAMEMALEDVLARHEVLRTVYPDGASGPKQSI 2205 Query 61 VH-ADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHV 119 + ++ G T ++D + LE + +++ D P+R+ ++ + EH Sbjct 2206 LSLSEAFGGLTVESVSDQDE------LESRVAAIGSSAIDVTVDVPIRVRLLTVSDTEHT 2259 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGPD 167 L +V HHIA D S D+ AYS G AD R S D Sbjct 2260 LAIVVHHIAADGWSMAPLARDVMIAYSARKDGIAPAWQPLTVQYADYSLWQREVLGSEDD 2319 Query 168 T---TEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 + ++YW +AD P+ +ELP S R R + D R+ +A+ Sbjct 2320 SESLISQQISYWTETLADLPDVIELPSDRSRPDVASMRGERFAFEISGDVHRRLDALARE 2379 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSA 283 T +M L +A L+ R + + D V PV RG +D +G F NT+ +R A Sbjct 2380 NNATLFMALHSALAVLMARLSGTSDIAVGTPVAGRGDEALDDLVGMFVNTLVLRTEVDQA 2439 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 +F +LL A D A GAFAH + +R+V L P R + +V + Sbjct 2440 QAFTDLLAAASDSALGAFAHSDVPFERLVDVLAPARSQARHPLFQVVLSLQNLAQTALEL 2499 Query 344 PGIECERYDLRSNITQLPLGFMVEFD------RAGVLVEAEHLVEILEPALAKQMLRHFG 397 PG+ + ++ + + L V + G+ E ++ + + + R Sbjct 2500 PGLAIKAAEIDTTTAKFDLELAVTESIGEDGIQQGLSAEFTFAADLFDVSTVEGFARRLV 2559 Query 398 VLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATA 457 +L+ ++ P + + ++ + L +V G+ TLV+++ P A A Sbjct 2560 RILETVVSVPSIVVGDIDILGATERGVLADVHGGQSVS---GTLVEILTAAAAVDPSADA 2616 Query 458 VVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYV 517 + ++G+ +Y +L+E S+RL LI +G+G EDRVA+ + +S D ++ V K+GA +V Sbjct 2617 IRFDGESISYRELDERSSRLARVLIAKGVGPEDRVAIAIPRSADSVLALWAVAKTGAAFV 2676 Query 518 PVDPSYPQDRLDFILADCDAKLVL--------------------RTPVRELAGYRSDDPT 557 PVDP+YP DR+ +++D A L L V A + Sbjct 2677 PVDPTYPVDRIAHMISDSGAVLGLALSDVEAGLPSALTWVVLDDEKTVAACAAESCAPVS 2736 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 D+DR + AY+IYTSGTTGLPKGV V + VA + Y + R L AS Sbjct 2737 DSDRRSAIDERQPAYVIYTSGTTGLPKGVVVTNAGVANFCAEQVERYALTADARTLHFAS 2796 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLP 677 PSFD S+ E+ + MVI P + L +L EG+T P+ L Sbjct 2797 PSFDASVLELLMAFGSASTMVIA-PTTVYGGAELAEILCSEGVTHAFVTPAALASV---- 2851 Query 678 GVSQWRTLQRVPIGGEPLPGEVADKFHATF-DALLHNF---YGPTETVINASRFKVVGPQ 733 S L+ V +GGE + K+ D + F YGPTE+ + AS Sbjct 2852 DPSGLDALRVVVVGGEASSRSLVAKWAVPLPDGGVRGFFNAYGPTESTV-ASNISDTLTA 2910 Query 734 GTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADP 793 R+ IG P +LD LQPVP GV GE+Y+ G VA GY + LTA RFVADP Sbjct 2911 FDRM-NIGGPIRGMAARILDGRLQPVPVGVAGELYVSGVQVARGYLGQPALTAGRFVADP 2969 Query 794 FN-PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVV 852 F PG R+YR+GDL R G +E+VGR+D QVKIRGFRIELG++ AA+ V QAV Sbjct 2970 FGAPGERLYRTGDLVRWIDGGAVEYVGRSDFQVKIRGFRIELGEIEAALTRCAGVAQAVA 3029 Query 853 VVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPI 912 +V G LV YV P AG + VD ++ V+ L YM+P + +VLD IP+ Sbjct 3030 LVRSDDHFGDRLVAYVVPQAGAE------VDPAQVIESVSTFLTGYMVPDSVLVLDSIPL 3083 Query 913 TAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSL 972 T GK D ALP P S ++AP T E +AQ+F E+LG +VG DD FF+LGG+SL Sbjct 3084 TTAGKTDIKALPSPVFESKV-YQAPITTVEETVAQVFSEVLGVAQVGRDDDFFELGGNSL 3142 Query 973 LATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSS 1032 +AT++ A + A V VR +FE +TV +LA ++ A L + LS Sbjct 3143 IATRVAARLGEALDTSVPVRALFEASTVQSLALRLELHAGSGATAPLIPQSRPARIPLSL 3202 Query 1033 SQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVP 1092 +Q R WF RF+ +AVNN+P A + G D A AA+ DVV RHE LRTVY ++ GV Sbjct 3203 AQQRMWFLNRFEPASAVNNVPAAIRISGALDVAALDAAVIDVVGRHESLRTVYPDVDGVG 3262 Query 1093 H----------QIIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST 1142 + + P + R AAG AEL FD+ ++ P+RA L Sbjct 3263 YQDVLDVQDVVVDLSPVSITEDRLAAGI------AELAT---VGFDVTSEVPLRAKLFKV 3313 Query 1143 PE-QTVLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSAL 1201 + + VL VVHHI+ D +S G L D++ AY AR+ P+W PLPVQYADYS+WQ + Sbjct 3314 GDSEYVLVFVVHHISTDGFSMGPLTRDVMVAYEARTRASVPAWTPLPVQYADYSLWQREV 3373 Query 1202 L---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKL 1258 L DD ++ Q +W L L + L D PRP + SG G VEF + A + + + Sbjct 3374 LGSEDDPRSVIAKQIAFWSDALADLPEQLDLPADRPRPEVASGRGAEVEFDIDATLHEAV 3433 Query 1259 AAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLR 1318 +++ T FM++ AA+ VVL + D+ IG P+AGR EA LD LIG F+N +VLR Sbjct 3434 NSIAHSSNSTPFMVVHAALTVVLSRLSATTDIAIGTPIAGRGEAQLDDLIGMFVNTLVLR 3493 Query 1319 NDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQM 1378 ++ + + ++L R++ L A+AH D+PF++VVE ++P RS +R+PLF + + Sbjct 3494 TEVDPSMSFTDLLASAREVDLQAFAHADVPFERVVEVLDPVRSQARHPLFQVALTF---- 3549 Query 1379 PQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYER 1432 Q+H T GD + + A+ DL + DE + Y T+L++ Sbjct 3550 -QNHEQTTLELGDLEVSIESADLALAKFDLQLTLTERTDEAGAPAGMSASLTYATDLFDE 3608 Query 1433 ATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAG 1478 +T F D LVR A P + +V+++ R +L R +AG Sbjct 3609 STVVEFGDRLVRTFRAVTADPTVAVGDVDIL-VDGERNLLSRFSAG 3653 Score = 704 bits (1816), Expect = 0.0, Method: Compositional matrix adjust. Identities = 513/1523 (34%), Positives = 743/1523 (49%), Gaps = 93/1523 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAV--------NAVARRHRILRTTYPVG 52 MWF Q DP+ +NI + G ++L LR A +A R I Y + Sbjct 40 MWFAQHLDPA-VPVNIAQYVELRGALELDALRQACADAGREIGSAFVRIFEIDAQPYQII 98 Query 53 DDGVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVR 112 D + + DLR +D RA R R P ++ D + T++R Sbjct 99 DPTLDDSVGYVDLRSEDDSHDAAMRWMRADRSR-----------PIDMLTDRLISATILR 147 Query 113 TAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASG------- 165 + + HH D F T + + YS G D PE PS AS Sbjct 148 LGENRYYWYTRVHHTILDGFGASTFVTRVAELYSARVEGRD--PE--PSEASDLRNVYEV 203 Query 166 ------PDTTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVA 219 E D YW + + E L G + P S + A R Sbjct 204 DNKYRQSSRFETDRKYWADKIENLDEISSLAGRSAAPAPVSRIDSAALSNHVEALLGRFL 263 Query 220 TMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGT-EDAIGYFGNTVAMRL 278 + T +V AAF A + + T +D ++ PV R + G N V +RL Sbjct 264 ERIEKTTVAGTVV--AAFAAYLAQMTGREDVSLSLPVSGRTTAVLRRSGGMVSNVVPLRL 321 Query 279 RPQSAMSFRELLTATRDIASGAFAHQRI-NLDRVVRELNPDRRHGAERMTRVSFGFREPD 337 + + +ELL R+ SGA HQR + D V P R + E Sbjct 322 TVTADTTVQELLDDVRNEMSGALRHQRYRHEDMVRGGDGPGRGGFFGPWINIMMFSTEL- 380 Query 338 GGGFNPPGIECERYDLRSNITQ-LPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHF 396 F P + E + L + + + L + ++ E + PA A++ F Sbjct 381 --AFGP--LVGELHILSTGLIEDLGVNLYQSVGDTRTHIDFESNPNLYAPADAQRNHSRF 436 Query 397 GVLLDNALAAPDNTLSG---LALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTP 453 L+ ++A + +A +ER+ L + F +T+ + Q RTP Sbjct 437 VEFLEKFVSAETSRKVWDLPVATDEERNKVALWNRTG---FHVASQTITEAFERQVERTP 493 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 DATAVV+EG TY + + +N L LI G+G E V + + +S DL+V + K+G Sbjct 494 DATAVVFEGASLTYAEFDSRANGLARQLIAMGVGPESLVGLSIRRSLDLMVGLYAIAKAG 553 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLRTPVREL---AGYR-------------SDDPT 557 +VPVDP +P +R +IL VL T ++ +G R S Sbjct 554 GAWVPVDPDHPAERTAYILESAQPTCVLTTARDDVDLPSGTRVIEIDTLDYGQLDSRPIV 613 Query 558 DADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVAS 617 +ADR+ PL NTAY+IYTSG+TG PKGVAV H + W EY + +D LQ + Sbjct 614 NADRLSPLHFSNTAYVIYTSGSTGRPKGVAVTHAAINNQLQWMNAEYGLSASDIYLQKTA 673 Query 618 PSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLP 677 +FDVS+ F L GA +V+ P G D Y+ + + G+T FVPS+L LF + Sbjct 674 TTFDVSLWGFFMPLQVGATLVVATPDGHRDPIYVANKIAELGVTITDFVPSMLTLFTANA 733 Query 678 GVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRI 737 +L+ V + GE LP E + F A LHN YGPTE ++ + ++ V T Sbjct 734 PAGSCDSLRHVFVIGEALPPETSSAFLELCGAGLHNLYGPTEAAVSVTYYEAVATDTTS- 792 Query 738 VPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPF-NP 796 VPIG P+ NT H+LD L+P P G GE+Y+ G +A GY R L+++RFVA+P+ Sbjct 793 VPIGMPQWNTQAHVLDGQLRPTPIGQPGELYLAGVQLARGYVGRPDLSSDRFVANPYGTA 852 Query 797 GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSD 856 G RMYR+GDL RR DG+++++GR D QVK RG RIELG++ + P V QAVV+V+ Sbjct 853 GERMYRTGDLVRRREDGNLDYIGRTDFQVKFRGQRIELGEIETVLLAHPDVSQAVVLVTV 912 Query 857 LPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHG 916 P G LVGYV P G + A V L R +LP YM+PAA +VLD +P+ G Sbjct 913 TPT-GDQLVGYVVPGPGRNIDAAV---LSEFAGR---SLPSYMVPAALMVLDALPLNTSG 965 Query 917 KIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATK 976 K+DRA LPEP AS ++R P+T ER +A +F ++LG +RVG DD FF+LGG+SL+AT+ Sbjct 966 KLDRAGLPEPVFASAKQYREPRTEIERVVADVFADVLGVERVGIDDDFFELGGNSLVATQ 1025 Query 977 LVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGP--VRLSSSQ 1034 LV V +A GV +GVRE+FE TV LA +++ + +AR + P V LS +Q Sbjct 1026 LVTRVGSALGVQLGVRELFESTTVATLAARAESV-AGNARQLTPLIAKPRPQVVPLSLAQ 1084 Query 1035 MRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQ 1094 R WF R D N+PF L G D +A AA+ D++ RHE LRT+Y ++ G Q Sbjct 1085 QRMWFINRLDPSTPAYNLPFTVRLTGSVDPSALHAAVMDLLERHESLRTIYPDVDGTAQQ 1144 Query 1095 IIQPPAEVPVRCA-AGSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLVV 1152 ++ P V + L A L + FD+ + P+R AL +P VL +V+ Sbjct 1145 LVLPVDRAAVELNPVKIRNSHLDAALFDVASRGFDVTLEIPVRVALFEVSPTDYVLVMVL 1204 Query 1153 HHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIV 1209 HHIA D S L DLL AY ARS P+W PLP+QYADY++WQ L +D Sbjct 1205 HHIAADGLSFRPLARDLLVAYSARSEKSAPAWTPLPIQYADYALWQREALGSDEDPRSES 1264 Query 1210 GPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTE 1269 Q ++W R L L + L D PRPA+ S G F++ KL ++R V+ Sbjct 1265 SRQINFWRRALADLPDQLDLPTDRPRPAIASNHGAKHHFQISERTTRKLNELARSRSVSL 1324 Query 1270 FMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLRE 1329 FM+LQAA A +L + G D+ IGAP+ GR + L+ +IG F+N +VLR ++ N E Sbjct 1325 FMVLQAAYATLLSRLSGTSDIAIGAPIGGRGDQALNDVIGMFVNTLVLRTEVDPNERFEE 1384 Query 1330 VLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPD 1389 +L R R+ L+AY H D+PF+++VE ++P RS +R+PLF + + ++ Sbjct 1385 LLARVRESGLSAYGHADVPFERLVEVLSPARSQARHPLFQVALTAEISGRRELEFSGVKA 1444 Query 1390 GDTTLRVLEPTFDAAQADLSVNFFACGDE----YRGHVIYRTELYERATAQRFADWLVRV 1445 L V FD +L V+ G E Y T+L++ AT FA VR+ Sbjct 1445 VAAELEVPVAKFD---LELMVSENPEGTEDADVLSATFTYATDLFDPATVNTFATRFVRI 1501 Query 1446 VEAFADRPDQPLREVEMVSAQAR 1468 ++A A RP+ + +++++S R Sbjct 1502 LDAVATRPETIVGDIDLLSRSER 1524 Score = 684 bits (1765), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/1533 (33%), Positives = 759/1533 (50%), Gaps = 88/1533 (5%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 ++ +A+ S L ++ + ++G +D RLR A + R+ LRT + DDG Sbjct 6922 LFHAMLAESSVDLYSVQMILTLSGKVDADRLRTAAQGIIDRYANLRTAFTADDDGTPVQI 6981 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V D+ W DL+D++ + L+ + + F+++ +R T V A ++ L Sbjct 6982 VLEDVAVPWRNIDLSDIAAVDREAALDEVLTADQATHFDMASPPLIRFTFVTMAEGDYRL 7041 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGAD-LGPEHRPSAASGPDTTEAD----LNY 175 ++ HHI D W V A G D + P R + D L Sbjct 7042 VVANHHIILD--GWSVPLLLQNLLALYATRGDDSILPRVRSYRNYLAWLVDQDRDRSLTA 7099 Query 176 WRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLA 235 W ++ EP L G T+ + + + + ++T A + +A G T ++ + Sbjct 7100 WADALSGVEEPTLLAQVTGGQEFTAL-SQKLNVSMSSETTAALTALAARLGVTANTIVQS 7158 Query 236 AFGALVHRYTHSDDFLVAAPVLNRG---AGTEDAIGYFGNTVAMRLRPQSAMSFRELLTA 292 A+ L+ T +DD + A V R G E +G F NT+ +R+R +A S EL+ Sbjct 7159 AWAVLLGALTGTDDVVFGATVSGRPPALTGVESMVGLFINTLPVRVRLDAAESVEELVAR 7218 Query 293 TRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPPGIECERY- 351 + + H + L V + + G T V F D G + Sbjct 7219 VQIEQARMLDHHYLGLTDVQKAADV----GTLFDTLVVFESYPVDREGLAAQADVLDGMM 7274 Query 352 --DLRSN-ITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNALAAPD 408 D+ S+ T PL ++ D + + +L + + A +L LL + P Sbjct 7275 IDDIASDDSTNYPLTLLIALDEQ-LHLTLRYLPDFFDADYATALLDRVLRLLSSVATDPS 7333 Query 409 NTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAVVYEGQHFTYH 468 + + ++D + + + E +++D + Q +P A A+ +EGQ +Y Sbjct 7334 VRVGDVDILDSVERSLVLEGWNDTARVVSGVSVLDGFDAQVAASPGAVALSFEGQSLSYA 7393 Query 469 DLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVDPSYPQDRL 528 + + NR +L+ G+G E V V + +S DL+V GV+++G YVPVDP P +R Sbjct 7394 EFDARVNRFARYLVSVGVGPESLVGVAVRRSVDLLVAVYGVLRAGGGYVPVDPDQPAERN 7453 Query 529 DFILADCDAKLVLRTP---------------VRELAGYRSDDPTDADRIRPLRPDNTAYL 573 ++LA V+ T V +++G+ +D DR+ PLR NTAY+ Sbjct 7454 GYVLAAASPVCVVSTSDVGFDAGVVPVVEVDVVDVSGFSGAPVSDVDRVAPLRSGNTAYV 7513 Query 574 IYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLAC 633 I+TSG+TG PKGVAV HR V W Y V +D +L +FDVS+ E+F LA Sbjct 7514 IFTSGSTGRPKGVAVSHRSVVNQVSWLAERYAVSGSDVVLFKTPVTFDVSVWELFVPLAV 7573 Query 634 GARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLF-----------LSLPGVSQW 682 GAR+V+ G D GYL +++ E ++ + FVPS+L +F +S G + Sbjct 7574 GARLVVATHDGHRDPGYLASVVAAESVSMVSFVPSMLEVFVDQVVDTSEATISRLGGAGL 7633 Query 683 RTLQRVPIGGEPLPGEVADKFHATFDAL-LHNFYGPTETVINASRFKVVGPQGTRIVPIG 741 +L+ + GE LP V + + ++ +HN YGPTE ++A+ + G +VP+G Sbjct 7634 GSLRVIFAAGEALPASVVGRVLSVLPSVEVHNLYGPTEFTVHATAAGPLDGVGV-VVPMG 7692 Query 742 RPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP-GSRM 800 P N+++ +LD L+PVP GV GE+Y+ G VA GY R L+AERFVA+PF GSRM Sbjct 7693 APVWNSSVLVLDSRLRPVPVGVAGELYLSGVQVARGYFGRVDLSAERFVANPFGGVGSRM 7752 Query 801 YRSGDLARR-NADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPR 859 YR+GD+ R G++E+VGR+D QVK+RG RIELG++ +A+ Q V + Sbjct 7753 YRTGDVVRWIGVSGELEYVGRSDFQVKLRGQRIELGEIESAVR-----DQVGVGSVVVVV 7807 Query 860 LGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKID 919 LV YVT A G DV R L YM+P+ +VVLD +P+ A GK+D Sbjct 7808 WRDQLVAYVTAAVGSSVDVDVVKVGVGER------LASYMVPSQFVVLDALPLNASGKLD 7861 Query 920 RAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVA 979 R LPEP + FRAP TA E +A +F E+LG DRVG DD FF+LGG+SL AT+ + Sbjct 7862 RKLLPEP-VFEVAVFRAPVTAMEEIVASVFAEVLGVDRVGLDDDFFELGGNSLNATRTIK 7920 Query 980 AVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWF 1039 + +A ++ VR +FE +TV LA H ++ R LT V+ + LS +Q R WF Sbjct 7921 RIADALDTELSVRVLFEASTVQDLAAHAESRTGSGGRVALTAVERPERIPLSLAQQRMWF 7980 Query 1040 NYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQIIQPP 1099 RFDG A NIP A L G D +A +AAI+DV+ RHE LRTVY EIG P Q+++P Sbjct 7981 LNRFDGSAAAYNIPMALRLQGDLDVSALSAAISDVIGRHESLRTVYPEIGDGPVQVVKPV 8040 Query 1100 AEVPVRCAA---GSDAAWLRAELNNERGYVFDLETDWPIRAALLS-TPEQTVLSLVVHHI 1155 + A G D L EL FD+ + PIR L ++ VL + +HHI Sbjct 8041 SSWSDEIVAEPTGVDE--LEGELVALASTRFDVTREIPIRIRLFQLASDEYVLGVAIHHI 8098 Query 1156 AGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGPQ 1212 + D S D++TAY +R G PSWAPL VQYADYS+WQ +L +D I Q Sbjct 8099 SADGSSMAPFARDVVTAYASRVAGYTPSWAPLDVQYADYSLWQREVLGSEEDAGSIASQQ 8158 Query 1213 RDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFML 1272 YW L GL + L D PRPA S G + F + A + +L+ ++R T FML Sbjct 8159 IAYWSNALAGLPDQLALPADRPRPATQSFRGGYLHFDIDAELHARLSGLARANNSTLFML 8218 Query 1273 LQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQ 1332 A A++L + G D+ +G P+AGR E LD LIG F+N +V R + ++L Sbjct 8219 THTAFAMLLARLSGTEDIAVGTPIAGRGERALDDLIGMFVNTLVFRTQIDSGAPFLDLLG 8278 Query 1333 RTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDT 1392 R R+ L A+AH D+PF+++VE +NP RS +R+PL+ V + + M + G Sbjct 8279 RVRETDLQAFAHSDVPFERLVEVLNPPRSTARHPLYQ-VGFLFQNMETGGLELPG----L 8333 Query 1393 TLRVLEPTFDAAQADLSVNFFACGDEYRGH---------VIYRTELYERATAQRFADWLV 1443 T++ ++ AQ DL D Y + Y +L++ +T Q FAD V Sbjct 8334 TVKGVDIDNGVAQFDLQ---LIVSDRYDANGSAAGITSMFSYAHDLFDESTVQDFADRFV 8390 Query 1444 RVVEAFADRPDQPLREVEMVSAQARRRILDRSN 1476 R++ A P + + ++ + RIL+R N Sbjct 8391 RLLAEIASDPSLTVGDFALMDSSESDRILNRWN 8423 Score = 456 bits (1172), Expect = 2e-125, Method: Compositional matrix adjust. Identities = 341/1064 (33%), Positives = 514/1064 (49%), Gaps = 86/1064 (8%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ D + A N+ V+ +TG +D++ L AV+ V RH +LRT YP DG+ Sbjct 5346 MWFLNQLDTNSAGNNVPVAITLTGKLDVSGLEQAVSDVVGRHEVLRTVYP-EVDGIGYQK 5404 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAP-FELSRDAPLRITVVRTAADEHV 119 + A P +L + EV F A F+++ + PLR + +T ADEHV Sbjct 5405 IVA---PADVGVNLAATLVSDSEIVSEV---TNFVATGFDVTTEVPLRARLFQTKADEHV 5458 Query 120 LLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGPD 167 L+ V HHI+ D S D+ AY G AD R S D Sbjct 5459 LVFVVHHISTDGFSMGPLTRDIMTAYYARTNGQAPTWTPLPVQYADYALWQREVLGSEDD 5518 Query 168 ---TTEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKN 224 + YW + PE L LPG S + A + + R+ + + Sbjct 5519 PQSIIAQQITYWAQALDGVPEQLNLPGDRARPAVFSGQGATFEFSIGQELHERLIGVGRE 5578 Query 225 TGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGT-EDAIGYFGNTVAMRLRPQSA 283 + +MV+ +A +L+ R + + D + AP+ RG +D IG F NT+ +R + Sbjct 5579 HNASMFMVVHSALASLLARLSGTTDITIGAPMAGRGESELDDLIGMFVNTLVLRTEVDPS 5638 Query 284 MSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNP 343 F LL++ R+ AFAH + +R+V L+P R + +V+ F+ Sbjct 5639 APFTTLLSSARETDLQAFAHSDLPFERLVEVLDPVRSRAHHPLFQVALAFQNLGQNSLAL 5698 Query 344 PGIECERYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDNA 403 PG+ + + + + L + G+ + ++ + + + +L+ Sbjct 5699 PGLTAAEFAIDETVAKFDLQLTISEVSEGLSATFTYATDLFDESTVRGFAARLMRILNGI 5758 Query 404 LAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKT--LVDLVNEQTTRTPDATAVVY- 460 P ++ + ++D + REV +R + V L +++ + R PD A+ Y Sbjct 5759 ATDPATSVGDIEILDSSE----REVLTSQRASSGVAQAPLAEILADAAARYPDNVALRYP 5814 Query 461 ------EGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGA 514 G+ TY +++E S++L LI +G+G+ED VAV + +S + ++ V K+GA Sbjct 5815 GTAQAAAGRSMTYREVDEWSSKLARVLINRGLGAEDLVAVSIPRSVESVLAVWAVSKTGA 5874 Query 515 VYVPVDPSYPQDRLDFILADCDAKLVLRTPVR-------------------ELAGYRSDD 555 VP+DP YP DR+ +L+D AK+ L V ++ S Sbjct 5875 AVVPIDPHYPADRIAHMLSDSGAKVGLTLDVERPNLTDDVEWLVVDGPRGEQMTAGVSAA 5934 Query 556 PTDAD-RIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQ 614 P DA+ R+RPL + A++IYTSGTTGLPKGV + +A + V Y V T R L Sbjct 5935 PIDAEERVRPLTTAHPAWVIYTSGTTGLPKGVVATNAGLASFSVTQAAHYLVKPTSRTLH 5994 Query 615 VASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFL 674 ASPSFD S+ E+F +A GA MVI P G+ L + R E +T P+ L Sbjct 5995 FASPSFDASMLELFLAVATGATMVIVPP-GVYGGDELAEVFRSERVTHAFITPAALASM- 6052 Query 675 SLPGVSQWRTLQRVPIGGEPLPGEVADKF--------HATFDALLHNFYGPTETVINASR 726 S L V +GGE E+ K+ A+ N YGPTET I + Sbjct 6053 ---DPSGLDDLTVVGVGGEAYSPELISKWTTGDGSTASASAPRTFLNVYGPTETTI-VTN 6108 Query 727 FKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTA 786 V G R+ IG + +LD L PVP GV GE+Y+ G V GYHRR GL+A Sbjct 6109 VSVPLLPGDRM-DIGATIGDMAAFVLDTRLNPVPLGVSGELYLSGPQVTRGYHRRPGLSA 6167 Query 787 ERFVADPF-NPGSRMYRSGDLARRNADG-----DIEFVGRADEQVKIRGFRIELGDVAAA 840 +RFVA+P NPG RMYR+GD+ R A +E+VGR D QVKIRGFRIELG++ A+ Sbjct 6168 DRFVANPHGNPGERMYRTGDVVRWVAGTAPSTYAVEYVGRNDFQVKIRGFRIELGEIDAS 6227 Query 841 IAVDPTVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYML 900 + P V A + + LP +LV YV G + +L +R LP +M+ Sbjct 6228 LTAHPEVEFAATMGTTLPSGAPALVSYVFT---GKNASVTSAELIEFVSRT---LPAHMV 6281 Query 901 PAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGA 960 PA+ +V ++P++ GK+DR ALP P + EFRAP T E+ L+++F ++LG DR+G Sbjct 6282 PASIMVSSDMPLSPAGKLDRKALPAP-VFETKEFRAPVTEMEQVLSEIFADVLGLDRIGT 6340 Query 961 DDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALA 1004 DDSFF GG S+++ +LV+ + A GV ++FE TV ALA Sbjct 6341 DDSFFAQGGDSIMSIQLVSRAK-ARGVVFAPSDVFESKTVAALA 6383 Score = 72.8 bits (177), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 118/464 (26%), Positives = 180/464 (39%), Gaps = 62/464 (13%) Query 1030 LSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYR--E 1087 LS++Q+ WF D P NI L G + +A A D A EI R E Sbjct 33 LSAAQLGMWFAQHLD-PAVPVNIAQYVELRGALELDALRQACAD--AGREIGSAFVRIFE 89 Query 1088 IGGVPHQIIQPPAE-----VPVRCAAGS-DAA--WLRAELNNERGYVFDLETDWPIRAAL 1139 I P+QII P + V +R S DAA W+RA+ R D+ TD I A + Sbjct 90 IDAQPYQIIDPTLDDSVGYVDLRSEDDSHDAAMRWMRAD----RSRPIDMLTDRLISATI 145 Query 1140 LSTPEQTVLSLV-VHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADY-SVW 1197 L E VHH D + A T + Y AR G+ P P + +D +V+ Sbjct 146 LRLGENRYYWYTRVHHTILDGFGASTFVTRVAELYSARVEGRDPE----PSEASDLRNVY 201 Query 1198 QSALLDDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDK 1257 + + R YW ++ L + L PA +S A A+ + Sbjct 202 EVDNKYRQSSRFETDRKYWADKIENLDEISSLAGRSAAPAPVSRIDSAALSNHVEALLGR 261 Query 1258 LAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVL 1317 + R T + AA A L + G DV + PV+GR+ A L + G N+V L Sbjct 262 F--LERIEKTTVAGTVVAAFAAYLAQMTGREDVSLSLPVSGRTTAVLRRSGGMVSNVVPL 319 Query 1318 RNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQ 1377 R + + T++E+L R A HQ + +V + + ++ + Sbjct 320 RLTVTADTTVQELLDDVRNEMSGALRHQRYRHEDMVRGGDGPGRGGFFGPWINIMMFSTE 379 Query 1378 MP------QDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVIYRT--EL 1429 + + H++ TG ++E DL VN + + R H+ + + L Sbjct 380 LAFGPLVGELHILSTG--------LIE--------DLGVNLYQSVGDTRTHIDFESNPNL 423 Query 1430 YERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILD 1473 Y A AQR V +E F VSA+ R++ D Sbjct 424 YAPADAQRNHSRFVEFLEKF-------------VSAETSRKVWD 454 Score = 64.3 bits (155), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 40/85 (48%), Positives = 48/85 (57%), Gaps = 5/85 (5%) Query 1472 LDRSNAGA---GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADP 1528 DR N G G A +LD L+PVPVGV G++Y G L +P+ TA RFVADP Sbjct 2911 FDRMNIGGPIRGMA-ARILDGRLQPVPVGVAGELYVSGVQVARGYLGQPALTAGRFVADP 2969 Query 1529 FAAQPGSRLYRNGERGVWKADGQLE 1553 F A PG RLYR G+ W G +E Sbjct 2970 FGA-PGERLYRTGDLVRWIDGGAVE 2993 Score = 62.8 bits (151), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 34/73 (47%), Positives = 43/73 (59%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVPVGV G++Y G L + T+TRFVA PFAA G LYR G+ Sbjct 3997 QVFVLDTRLAPVPVGVAGEMYVSGVQLARGYLGQAGLTSTRFVASPFAA--GEVLYRTGD 4054 Query 1543 RGVWKADGQLELL 1555 W + G LE L Sbjct 4055 VASWNSAGDLEYL 4067 Score = 61.2 bits (147), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/73 (46%), Positives = 42/73 (58%), Gaps = 2/73 (2%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVPVGV G++Y G L + T+TRFVA PF A G LYR G+ Sbjct 5064 QVFVLDTRLAPVPVGVAGEMYVSGVQLARGYLGQAGLTSTRFVASPFTA--GEVLYRTGD 5121 Query 1543 RGVWKADGQLELL 1555 W + G LE L Sbjct 5122 VASWNSAGDLEYL 5134 Score = 56.6 bits (135), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/71 (43%), Positives = 41/71 (58%), Gaps = 1/71 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +V++LD L PVPVGV G++Y G R T+ RFVA+ F GSRLYR G+ Sbjct 8756 QVFVLDTRLHPVPVGVTGELYLAGAQLARGYHGRADLTSERFVANVF-GDAGSRLYRTGD 8814 Query 1543 RGVWKADGQLE 1553 W +G+L+ Sbjct 8815 LVRWTQNGELD 8825 Score = 56.6 bits (135), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/67 (48%), Positives = 41/67 (62%), Gaps = 1/67 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 TE ER +A + ADVL V VG DDFF LGG+S++ATQ+ R G+ L R +FE Sbjct 988 TEIERVVADVFADVLGVERVGIDDDFFELGGNSLVATQLVTRVGSALGVQLGVRELFEST 1047 Query 1635 VLCELAA 1641 + LAA Sbjct 1048 TVATLAA 1054 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/76 (40%), Positives = 41/76 (54%), Gaps = 0/76 (0%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTARMVFEHPV 1635 TE E+ L+ I ADVL + +G D FF GGDSI++ Q+ +RA+ G+ VFE Sbjct 6319 TEMEQVLSEIFADVLGLDRIGTDDSFFAQGGDSIMSIQLVSRAKARGVVFAPSDVFESKT 6378 Query 1636 LCELAAAVDAKPHVEA 1651 + LA VEA Sbjct 6379 VAALAEVAKYAADVEA 6394 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 31/74 (42%), Positives = 41/74 (56%), Gaps = 2/74 (2%) Query 1481 TARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRN 1540 + V +LD L+PVPVGV G++Y G R +A RFVA+PF GSR+YR Sbjct 7697 NSSVLVLDSRLRPVPVGVAGELYLSGVQVARGYFGRVDLSAERFVANPFGGV-GSRMYRT 7755 Query 1541 GERGVW-KADGQLE 1553 G+ W G+LE Sbjct 7756 GDVVRWIGVSGELE 7769 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/78 (42%), Positives = 42/78 (54%), Gaps = 3/78 (3%) Query 1473 DRSNAGA--GTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFA 1530 DR + GA G ++LD L PVP+GV G++Y G RP +A RFVA+P Sbjct 6117 DRMDIGATIGDMAAFVLDTRLNPVPLGVSGELYLSGPQVTRGYHRRPGLSADRFVANPH- 6175 Query 1531 AQPGSRLYRNGERGVWKA 1548 PG R+YR G+ W A Sbjct 6176 GNPGERMYRTGDVVRWVA 6193 Score = 54.3 bits (129), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 31/68 (46%), Positives = 44/68 (65%), Gaps = 5/68 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFE 1632 T E +A + ++VL V +VGR DDFF LGG+S++AT+VAAR A D +P+ R +FE Sbjct 3109 TTVEETVAQVFSEVLGVAQVGRDDDFFELGGNSLIATRVAARLGEALDTSVPV--RALFE 3166 Query 1633 HPVLCELA 1640 + LA Sbjct 3167 ASTVQSLA 3174 Score = 53.5 bits (127), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/68 (48%), Positives = 43/68 (64%), Gaps = 5/68 (7%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFEHPV 1635 E +A + ADVL V VG DDFF LGG+S++ATQV +R A D IP+ R++FE Sbjct 8944 EEIVAGVFADVLGVARVGLDDDFFELGGNSLVATQVVSRLGEALDAQIPV--RVIFEAST 9001 Query 1636 LCELAAAV 1643 + LA+ V Sbjct 9002 VGALASRV 9009 Score = 50.4 bits (119), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/73 (43%), Positives = 46/73 (64%), Gaps = 5/73 (6%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAA---RARDGGIPLTARMVFE 1632 T E +A ++ADVL V VG DDFF LGG+S++ATQV + RA D +P+ R +F+ Sbjct 2048 TPVEEIVAQVIADVLGVERVGLDDDFFELGGNSLVATQVTSRLGRALDTTVPV--RTLFD 2105 Query 1633 HPVLCELAAAVDA 1645 + LAA +++ Sbjct 2106 VSTVEALAAHIES 2118 Score = 48.5 bits (114), Expect = 0.012, Method: Compositional matrix adjust. Identities = 24/73 (33%), Positives = 41/73 (57%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 + ++LD L+P P+G G++Y G + RP ++ RFVA+P+ G R+YR G+ Sbjct 803 QAHVLDGQLRPTPIGQPGELYLAGVQLARGYVGRPDLSSDRFVANPYGTA-GERMYRTGD 861 Query 1543 RGVWKADGQLELL 1555 + DG L+ + Sbjct 862 LVRRREDGNLDYI 874 Score = 48.1 bits (113), Expect = 0.013, Method: Compositional matrix adjust. Identities = 28/72 (39%), Positives = 43/72 (60%), Gaps = 1/72 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHP 1634 T E +A++ A+VL V VG DDFF LGG+S+ AT+ R D L+ R++FE Sbjct 7880 TAMEEIVASVFAEVLGVDRVGLDDDFFELGGNSLNATRTIKRIADALDTELSVRVLFEAS 7939 Query 1635 VLCELAAAVDAK 1646 + +LAA +++ Sbjct 7940 TVQDLAAHAESR 7951 Score = 46.6 bits (109), Expect = 0.038, Method: Compositional matrix adjust. Identities = 24/61 (40%), Positives = 35/61 (58%), Gaps = 1/61 (1%) Query 1486 LLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGERGV 1545 +LD+ L PVPVG G++Y+ G R +A RFVA+P++ G R+YR G+ Sbjct 1860 VLDERLHPVPVGTRGELYFAGAALARGYHERRGLSAERFVANPYSPD-GERMYRTGDVVR 1918 Query 1546 W 1546 W Sbjct 1919 W 1919 Score = 45.8 bits (107), Expect = 0.062, Method: Compositional matrix adjust. Identities = 30/71 (43%), Positives = 42/71 (60%), Gaps = 5/71 (7%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFEHPV 1635 E +A ADVL V VG DDFF LGG+S++ATQV +R A D + + R +FE Sbjct 4184 EEVVAQTFADVLGVERVGLDDDFFALGGNSLIATQVTSRLGQALDASV--SVRELFEAST 4241 Query 1636 LCELAAAVDAK 1646 + LAA + ++ Sbjct 4242 VEGLAARLGSR 4252 Score = 45.8 bits (107), Expect = 0.062, Method: Compositional matrix adjust. Identities = 30/71 (43%), Positives = 42/71 (60%), Gaps = 5/71 (7%) Query 1579 ERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAAR---ARDGGIPLTARMVFEHPV 1635 E +A ADVL V VG DDFF LGG+S++ATQV +R A D + + R +FE Sbjct 5251 EEVVAQTFADVLGVERVGLDDDFFALGGNSLIATQVTSRLGQALDASV--SVRELFEAST 5308 Query 1636 LCELAAAVDAK 1646 + LAA + ++ Sbjct 5309 VEGLAARLGSR 5319 >gi|327179725|gb|AEA30273.1| peptide synthetase [Streptomyces sp. Acta 2897] Length=4728 Score = 850 bits (2195), Expect = 0.0, Method: Compositional matrix adjust. Identities = 556/1541 (37%), Positives = 804/1541 (53%), Gaps = 93/1541 (6%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + N+ ++ R+TG +D+ LR A+ VA RH +LRT +P D Q Sbjct 1058 LWFINQFEGPSTAYNVPMAARLTGPLDVDALRAALADVAGRHELLRTVFPDRDGTPCQVV 1117 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVL 120 V A + + D+ LE F+L+ + P+R ++R A+EHVL Sbjct 1118 VDAT-----PELPVADVDPAG----LEAALTEAASGGFDLTAEPPVRARLLRLGAEEHVL 1168 Query 121 LLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRP--------------SAASGP 166 L++ HHI D+ S F DL+ AY G + E P + P Sbjct 1169 LVLMHHIVMDEWSAVPFGRDLSVAYDARCDGDEPAFEPLPVQYADFALWQHDVLGSEDDP 1228 Query 167 DT-TEADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAKNT 225 D+ L++WR +A P+ L LP ++R R+ + R+ +++N Sbjct 1229 DSPVSRQLDFWRGTLAGLPDELNLPVDRPRPAVATYRGGTVGFRINQEVHQRLVALSRNC 1288 Query 226 GCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQSAM 284 + +M L A L++R D V P+ R +D +G+F NT+ +R Sbjct 1289 QASVFMTLQAGLAVLLNRLGAGTDIPVGTPIAGRSDESLDDLVGFFINTLVLRTDLSQDP 1348 Query 285 SFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFNPP 344 FR LL R+ A+AHQ + +R+V +NPDR + +V F Sbjct 1349 DFRTLLGQVREADLAAYAHQEVPFERLVEVINPDRSMSRHPLFQVMLTLHNNPSAPFRLS 1408 Query 345 GIECERYDLRSNITQLPLGFMVEFDRA------GVLVEAEHLVEILEPALAKQMLRHFGV 398 G+E + + + + L F + + GV E+ ++ + A+++ + Sbjct 1409 GVEVGTQRVDTQVAKFDLLFSLRESYSADGRPGGVEGFVEYSKDLFDETTAERVAAAYVR 1468 Query 399 LLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDTPVKTLVDLVNEQTTRTPDATAV 458 +L+N LA P + + ++D L + P +L L ++ P A A+ Sbjct 1469 VLENVLAEPGRPVGRIEVLDPVARHELLVARNDTEHEVPATSLPALFQDRVAAHPGAPAL 1528 Query 459 VYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVP 518 VY + +Y LNE +NRL L+ +G G E V + L +S DL+V L V+KSGA Y+P Sbjct 1529 VYGDEELSYAGLNERANRLARLLMARGAGPERVVGLALPRSTDLVVALLAVLKSGAGYLP 1588 Query 519 VDPSYPQDRLDFILADCDAKLVLRTP------------------VR-ELAGYRSDDPTDA 559 +DP YP +R+ F+LAD +VL T VR ELAG DP D Sbjct 1589 LDPEYPAERISFMLADAAPDVVLTTTDVAGRLPAGPMLALDDPQVRAELAGLTPTDPRDD 1648 Query 560 DRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPS 619 +R PLRP + AYLIYTSG+TG PKGV +P + W + R+ Q + S Sbjct 1649 ERTSPLRPQHPAYLIYTSGSTGRPKGVVLPSGALINLMAWHAATLPGEPGARVAQFTAIS 1708 Query 620 FDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSL----LGLFLS 675 FDVS EI L G +V+P D A L + IT + + P++ LG ++ Sbjct 1709 FDVSAQEILSALLDGKTLVMPEEDTRRDPARFAAWLAERDITEL-YAPTMMLDALGEAVA 1767 Query 676 LPGVSQWRTLQRVPIGGEPLP--GEVADKFHATFDALLHNFYGPTETVINASRFKVVGP- 732 G ++ L+ V GE L G V D A LHN YGP+ET + + GP Sbjct 1768 EHG-TELPALRHVAQAGEALTLGGRVRDLCDAP-GRTLHNHYGPSETHVVTAHTLSDGPS 1825 Query 733 -QGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVA 791 + PIGRP NT +++LD +L+PVP GV GE+YI G +A GYH R GLTAERF A Sbjct 1826 DRARNAAPIGRPVWNTQVYVLDAALRPVPDGVTGELYIAGAQLARGYHHRPGLTAERFTA 1885 Query 792 DPFN-PGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQA 850 DPF PG RMYR+GDL R N+DG++++ GRAD QVK+RGFRIELG++ A + P V QA Sbjct 1886 DPFGAPGGRMYRTGDLVRWNSDGELDYAGRADHQVKVRGFRIELGEIEAVLRTHPGVAQA 1945 Query 851 VVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEI 910 VV + PR G+ LVGY PAAG PA+ ++A VAA LP+YM+P A+V+L E Sbjct 1946 AVVAQEDPRGGRRLVGYAVPAAGAVRPAE-------LKAHVAAGLPDYMVPGAFVLLAEF 1998 Query 911 PITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGH 970 P+ GK+DRAALP P+ R P+ E L LF E+L VG DD FF LGGH Sbjct 1999 PLLPSGKLDRAALPVPETEVRPAGRGPRGPREEILCGLFAEVLQLPSVGVDDDFFTLGGH 2058 Query 971 SLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRL 1030 SLLATKLV+ VR A GV++ VR++FE TV ALA + + +AR + +D V L Sbjct 2059 SLLATKLVSRVRGALGVELAVRDVFEAPTVAALAPKVT--GASAARAAVRPMDRTELVPL 2116 Query 1031 SSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGG 1090 S +Q R WF +R +GP++ N+P AA L+GP D A A+ DVVARHE LRT + EI G Sbjct 2117 SFAQRRLWFLHRLEGPSSTYNLPLAARLNGPIDVAALREALGDVVARHESLRTTFPEIDG 2176 Query 1091 VPHQIIQPPAEV-PVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVL 1148 +P Q I P P D A L + + FDL + P+RA L ++ VL Sbjct 2177 IPRQSIAAPGRTAPELVLRDVDEAGLNIAMEEAAFHGFDLAAELPMRAHLYRLGADRHVL 2236 Query 1149 SLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGI 1208 +V+HHIAGD S + DL AY AR G+ P WAPLP+QYADY++WQ +L Sbjct 2237 LIVMHHIAGDGLSMAPMARDLAEAYTARLEGRAPGWAPLPIQYADYTLWQREVLGSETET 2296 Query 1209 ---VGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDL 1265 + Q +YW L GL E L D PRP + S G V F + A + ++A ++R Sbjct 2297 DSEIARQLEYWRTTLAGLPEELRLPTDRPRPPVASHKGSTVPFAVPAELHLRMAELARRT 2356 Query 1266 GVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNP 1325 + FM+ QAA+A +L + G G D+ +G PVAGR++ LD L+GFF+N +VLR D G+P Sbjct 2357 RTSLFMVGQAALAALLTRIGAGTDIALGTPVAGRNDEALDDLVGFFVNTLVLRTDTSGDP 2416 Query 1326 TLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVI- 1384 + E+L+R R+ LAAYAHQ++PF+++VE +NP+RSL+R+PLF + ++++ + + Sbjct 2417 SFTELLERVREDDLAAYAHQEVPFERLVEVLNPERSLARHPLFQVWLNLQNTADIEISLP 2476 Query 1385 --DTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDE------YRGHVIYRTELYERATAQ 1436 + GP G AA+ DL+ + DE G V Y +L++ AT Sbjct 2477 GTEVGPQGV--------GIGAAKFDLAFSLRERYDEQGRPAGMTGLVEYSDDLFDPATVS 2528 Query 1437 RFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNA 1477 R AD L+R+++ PD P+ V+++S RR++ NA Sbjct 2529 RMADRLLRLLDGVCADPDLPVARVDVLSPAERRQVTAGFNA 2569 Score = 766 bits (1977), Expect = 0.0, Method: Compositional matrix adjust. Identities = 565/1567 (37%), Positives = 794/1567 (51%), Gaps = 113/1567 (7%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 +WF+ + + N+ ++ R+ G ID+A LR+A+ V RH LRTT+P DG+ + + Sbjct 2123 LWFLHRLEGPSSTYNLPLAARLNGPIDVAALREALGDVVARHESLRTTFP-EIDGIPRQS 2181 Query 61 VHADLRPGWTQYDLT--DLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEH 118 + A PG T +L D+ + + +E A F +L+ + P+R + R AD H Sbjct 2182 IAA---PGRTAPELVLRDVDEAGLNIAMEEAAFHGF----DLAAELPMRAHLYRLGADRH 2234 Query 119 VLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLG------------ADLGPEHRPSAASGP 166 VLL+V HHIA D S DL +AY+ G AD R S Sbjct 2235 VLLIVMHHIAGDGLSMAPMARDLAEAYTARLEGRAPGWAPLPIQYADYTLWQREVLGSET 2294 Query 167 DTTEA---DLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVATMAK 223 +T L YWR +A PE L LP S + + +PA+ R+A +A+ Sbjct 2295 ETDSEIARQLEYWRTTLAGLPEELRLPTDRPRPPVASHKGSTVPFAVPAELHLRMAELAR 2354 Query 224 NTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRLRPQS 282 T + +MV AA AL+ R D + PV R +D +G+F NT+ +R Sbjct 2355 RTRTSLFMVGQAALAALLTRIGAGTDIALGTPVAGRNDEALDDLVGFFVNTLVLRTDTSG 2414 Query 283 AMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDGGGFN 342 SF ELL R+ A+AHQ + +R+V LNP+R + +V + + Sbjct 2415 DPSFTELLERVREDDLAAYAHQEVPFERLVEVLNPERSLARHPLFQVWLNLQNTADIEIS 2474 Query 343 PPGIECERYDLRSNITQLPLGFMVE--FDRAGVLVEAEHLVE----ILEPALAKQMLRHF 396 PG E + + L F + +D G LVE + +PA +M Sbjct 2475 LPGTEVGPQGVGIGAAKFDLAFSLRERYDEQGRPAGMTGLVEYSDDLFDPATVSRMADRL 2534 Query 397 GVLLDNALAAPDNTLSGLALMDERDAARLREVSRGER---FDTPVKTLVDLVNEQTTRTP 453 LLD A PD + A +D A R+V+ G +D P T L Q TP Sbjct 2535 LRLLDGVCADPDLPV---ARVDVLSPAERRQVTAGFNATGYDVPRGTFAALFAHQAAATP 2591 Query 454 DATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSG 513 + A+ Y+G +Y L+ + L L +G+G ED VAV L ++P L+V L V K+G Sbjct 2592 GSVAISYDGSELSYAQLDAEVDGLARLLTRRGVGPEDVVAVALPRTPRLVVALLAVAKAG 2651 Query 514 AVYVPVDPSYPQDRLDFILADCDAKLVLR------------TPVRELAGYRSDD-PTDAD 560 AVY+PVDP YP +R+ FILAD L++ P L G +DD P + Sbjct 2652 AVYLPVDPQYPAERVSFILADARPALLVTDGPAAAGLPGSDVPRLLLDGPSADDGPAGSQ 2711 Query 561 RIRP-----LRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQV 615 P P N AY+IYTSG+TG PKGV V H + F + ++ +D + R+LQ Sbjct 2712 DTAPGTARRAGPANAAYMIYTSGSTGTPKGVVVTHEGIGS-FGAIRKQFGLDASSRMLQF 2770 Query 616 ASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLS 675 AS SFD +I EI L G +V+ L L ALL E +T + P+ L + Sbjct 2771 ASSSFDAAIWEILAPLLVGGALVMAPSDDLAVGEPLIALLARERVTHANIPPAALAV--- 2827 Query 676 LPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGT 735 LP + + + G P +A + L N YGPTE + + + + P T Sbjct 2828 LPQGALPDGMNVILAGEASAPDLIA---RWSDGRRLLNAYGPTEATVCVTVSEPLTPGTT 2884 Query 736 RIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFN 795 PIGRP N + +LD++LQPVP G GE Y+ G +A GY R GLTAERFVADP Sbjct 2885 P--PIGRPLWNVRVFVLDEALQPVPVGTPGEAYLAGDGLARGYAGRPGLTAERFVADPHG 2942 Query 796 P-GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVV 854 P GSRMYR+GDL R DG++EFVGRAD+QVKIRG RIE G+V + + V QA VV Sbjct 2943 PAGSRMYRTGDLVRWLPDGNLEFVGRADDQVKIRGHRIEPGEVESLLVSHEGVAQAAVVA 3002 Query 855 SDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITA 914 + + LV YV A G P+ +R VAA LPEYM+P+A V L +P+T Sbjct 3003 REDEPGDRRLVAYVVAAPDGAAPSAA-----ELREHVAARLPEYMVPSAVVTLPVLPLTP 3057 Query 915 HGKIDRAALPEPQI-ASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLL 973 +GKIDR ALP P+ A + R P+ TE RL ++F E+L + V + +FF+LGGHSL Sbjct 3058 NGKIDRRALPAPETTAPGPDGREPRNETESRLRRIFEEVLHSEDVDVEANFFELGGHSLQ 3117 Query 974 ATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSS 1033 ATKLV+ +R+ F ++ +R+ FE V LA I ++ AR + R + + LS + Sbjct 3118 ATKLVSRIRSEFDAELPLRDFFEHPNVAGLAVLIG--GAEEARESVVRQERPEHIPLSFA 3175 Query 1034 QMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPH 1093 Q R WF R +GP+ NIP + L GP D A AA+ DVVARHE LRT + E G P Sbjct 3176 QRRMWFLNRLEGPSPTYNIPLSMRLTGPLDARALQAALGDVVARHESLRTTFPETDGKPR 3235 Query 1094 Q-IIQPPAEVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLV 1151 Q I+ P A L A + Y FDL + P+R L + P VL + Sbjct 3236 QEILDAATATPRLRIADVTPDELDAAVAGAVAYGFDLGAELPVRVHLFTVGPRDHVLVFL 3295 Query 1152 VHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGI 1208 VHHIA D WS G L DL AYRAR G+ P W PL VQYADY++WQ LL DD Sbjct 3296 VHHIASDGWSLGPLLRDLSDAYRARVAGRAPRWTPLAVQYADYAIWQRDLLGSEDDQDSR 3355 Query 1209 VGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVT 1268 + + YW QL G+ E L D PRPA S G+ V RL L +++ G + Sbjct 3356 LSAELSYWRAQLAGMPEELALPTDLPRPARPSHRGELVRLRLRPEPHRALVDLAKATGAS 3415 Query 1269 EFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLR 1328 FM+LQAA+A +L + G G D+P+G VAGR++ LD+L+GFF+N +VLR D G+PT R Sbjct 3416 PFMVLQAALAALLTRLGAGTDIPVGTTVAGRTDDALDELVGFFVNTLVLRTDTSGDPTFR 3475 Query 1329 EVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMP------QDH 1382 E+++R R +AAY +Q++PF+++VE +NP RS+SR+PL +++++ P +D Sbjct 3476 ELVERARVTDVAAYENQNVPFERLVEVLNPSRSMSRHPLLQVMLNLLNTPPAELSLGEDL 3535 Query 1383 VIDTGPDGDTTLRVLEPTFDAAQADLSVNFFACGDEYRGHVI------YRTELYERATAQ 1436 I P+G LRV A+ DL+ N D G Y T+L+ T Q Sbjct 3536 TIAQQPNG---LRV-------AKFDLAFNLAETVDAAGGPDGVVGVVEYSTDLFTHDTVQ 3585 Query 1437 RFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDRSNAGAGTARVYLLDDALKPVPV 1496 AD L+ ++E PD+P E ++++ R +L GTA PVP Sbjct 3586 LLADRLITLLERMLAEPDRPTGEHDLLTGDERELLL---GEWGGTA---------APVPA 3633 Query 1497 GVVGDVY 1503 G +++ Sbjct 3634 GTFAELF 3640 Score = 734 bits (1896), Expect = 0.0, Method: Compositional matrix adjust. Identities = 542/1529 (36%), Positives = 774/1529 (51%), Gaps = 133/1529 (8%) Query 16 ICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPTVHADLRPGWTQYDLT 75 IC+ + GD+D+A +R +V ++ RH LR + + ++ W ++DL Sbjct 37 ICLD--LEGDLDVAAMRASVASLLERHPNLRAAFRYERLSRPVQLIPREVALPWQEFDLR 94 Query 76 DLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTAADEHVLLLVAHHIAWDDGSWR 135 DL + Q RLE E F+L+R L T++ H L+L HHI D S Sbjct 95 DLPEEQQAERLEEHTAAESERTFDLTRPPLLHFTLIHHGEGRHRLILAHHHILLDGWSVG 154 Query 136 VFFTDLTQAYSRA-------------DLGADLGPEHRPSAASGPDTTEADLNYWRAIMAD 182 TDL Y+ D A L + RP+A WR ++A Sbjct 155 RLMTDLFTLYAAGGDASGLPAVTPYRDYLAWLARQDRPAAEEA----------WRTVLAG 204 Query 183 PPEPLEL--PGPAGTCVPTSWRAARATLRLPADTAARVATMAKNTGCTPYMVLLAAFGAL 240 EP L GP P R + +PA+ + + A+ T V A+ + Sbjct 205 VEEPTRLVPEGPEAAVAPE-----RLLVEVPAELSRALTETARRHDLTLNTVFQGAWAVV 259 Query 241 VHRYTHSDDFLVAAPVLNRGA---GTEDAIGYFGNTVAMRLRPQSAMSFRELLTATRDIA 297 + R T DD + V R A G ED IG F NT+ +R+R A E+L + Sbjct 260 LGRLTGRDDVVFGGTVSGRPADIPGVEDVIGLFINTLPVRVRLDPAEPVGEMLARFQRQQ 319 Query 298 SGAFAHQRINLDRVVR------ELNPDRRHGAERMTRVSFGFREPDGGGFNPP-GIECER 350 +G AHQ +NL + EL D E GFRE G G + Sbjct 320 AGLMAHQHLNLPDIHALAGAPGELF-DTITVTENYPFDEKGFRELAGLTIAAAHGADANH 378 Query 351 YDLRSNITQLP-------LGFMVE-FDRAGVLVEAEHLVEILEPALAKQMLRHFGVLLDN 402 Y L ++ LP G+ + F A V LV +LE A+ ++ R G L Sbjct 379 YPL--SVAALPGETLRFRFGYRPDVFGAADVEAIGARLVRVLE-AVVREPGRPVGRL--- 432 Query 403 ALAAPDNTLSGLALMDERDAARLREV--SRGERFDTPVKTLVDLVNEQTTRTPDATAVVY 460 + L+G A E+ +R +T+ +L E+ PD AVV+ Sbjct 433 ------DVLAG---------AEREEILHTRNATGAASPRTVPELFAERVALAPDDPAVVF 477 Query 461 EGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKSPDLIVTALGVVKSGAVYVPVD 520 EG + Y +L+ +NRL H L+ G+ ED VA+ L +S DL V L V K+GA Y+PVD Sbjct 478 EGTTYAYAELDRRANRLAHHLVSAGVRPEDFVALALPRSADLAVAVLAVHKAGAAYLPVD 537 Query 521 PSYPQDRLDFILADCDAKLVLRTPVRE---LAGYRS-----DDPTDADRIRPLRP----- 567 P YP +R+ ++L D +VL T +G R+ DDP A + Sbjct 538 PDYPAERIAYMLDDARPGVVLTTTALADTLPSGDRAARIVLDDPATAALVAAAPGDAAPA 597 Query 568 -----DNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYDVDDTDRLLQVASPSFDV 622 D+ AYLIYTSG+TG PKGV V HR V+ ++V R+LQ AS SFD Sbjct 598 VTASVDSPAYLIYTSGSTGRPKGVVVTHRGVSSLVASQVERFEVGPGSRVLQFASISFDA 657 Query 623 SIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHFVPSLLGLFLSLPGVSQW 682 + E+ L GA +V+ L L L+ ++G+T P+ L + L + + Sbjct 658 AFWELVMGLLSGAALVLAPADRLNPGRPLADLVAEQGVTHATIPPAALAV-LEPDALPEG 716 Query 683 RTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINASRFKVVGPQGTRIVPIGR 742 TL + GE E+ ++ A + N YGP+ET + A+ + G + PIG Sbjct 717 ITLV---VAGEATSPELVGRWSAGRRMI--NAYGPSETTVCATMSAPL--SGEAVPPIGG 769 Query 743 PKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLTAERFVADPFNP-GSRMY 801 P T +++LD +L+PV GV GE+Y+ G+ +A GY R L+AERFVADPF P GSRMY Sbjct 770 PITGTRVYVLDAALRPVLPGVRGELYVAGSGLARGYLDRPALSAERFVADPFGPAGSRMY 829 Query 802 RSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDPTVGQAVVVVSDLPRLG 861 R+GD+A G ++F GRAD QVKIRGFRIELG++ +A+ + QA VV+ + Sbjct 830 RTGDVATWTDAGQLDFNGRADHQVKIRGFRIELGEIESALLAHDGIAQAAVVIREDRPGD 889 Query 862 KSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYVVLDEIPITAHGKIDRA 921 + LV Y+ G D P +R R+ +LP+YM+PAA+V LDE+P+T +GK+D+ Sbjct 890 RRLVAYLVARPGADRPTAA-----LLRTRLGESLPDYMVPAAFVTLDELPVTPNGKLDKR 944 Query 922 ALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFFDLGGHSLLATKLVAAV 981 ALP P + RAP+T E L LF E+LG V DDSFF+LGGHSLLAT+LV + Sbjct 945 ALPAPDFSGVASGRAPRTPQEEILCGLFAEILGASVVSIDDSFFELGGHSLLATRLVTRI 1004 Query 982 RNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHDGPVRLSSSQMRSWFNY 1041 R+ FGV +R +FE +V LA + T D + R R+ V+ V LS Q R WF Sbjct 1005 RSVFGVQFSLRSLFEDPSVAGLAQQLTT-DGTATR-RVEAVERPADVPLSLQQTRLWFIN 1062 Query 1042 RFDGPNAVNNIPFAAALHGPCDTNAFAAAITDVVARHEILRTVYREIGGVPHQII-QPPA 1100 +F+GP+ N+P AA L GP D +A AA+ DV RHE+LRTV+ + G P Q++ Sbjct 1063 QFEGPSTAYNVPMAARLTGPLDVDALRAALADVAGRHELLRTVFPDRDGTPCQVVVDATP 1122 Query 1101 EVPVRCAAGSDAAWLRAELNNERGYVFDLETDWPIRAALLST-PEQTVLSLVVHHIAGDH 1159 E+PV A D A L A L FDL + P+RA LL E+ VL +++HHI D Sbjct 1123 ELPV---ADVDPAGLEAALTEAASGGFDLTAEPPVRARLLRLGAEEHVLLVLMHHIVMDE 1179 Query 1160 WSAGVLFTDLLTAYRARSTGQRPSWAPLPVQYADYSVWQSALL---DDGAGIVGPQRDYW 1216 WSA DL AY AR G P++ PLPVQYAD+++WQ +L DD V Q D+W Sbjct 1180 WSAVPFGRDLSVAYDARCDGDEPAFEPLPVQYADFALWQHDVLGSEDDPDSPVSRQLDFW 1239 Query 1217 IRQLGGLAGETGLRPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAA 1276 L GL E L D PRPA+ + G V FR+ + +L A+SR+ + FM LQA Sbjct 1240 RGTLAGLPDELNLPVDRPRPAVATYRGGTVGFRINQEVHQRLVALSRNCQASVFMTLQAG 1299 Query 1277 VAVVLHKAGGGVDVPIGAPVAGRSEANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQ 1336 +AV+L++ G G D+P+G P+AGRS+ +LD L+GFFIN +VLR DL +P R +L + R+ Sbjct 1300 LAVLLNRLGAGTDIPVGTPIAGRSDESLDDLVGFFINTLVLRTDLSQDPDFRTLLGQVRE 1359 Query 1337 MALAAYAHQDLPFDQVVEAVNPQRSLSRNPLFDIVVHVREQMPQDHVIDTGPDGDTTLRV 1396 LAAYAHQ++PF+++VE +NP RS+SR+PLF +++ + H + P + + V Sbjct 1360 ADLAAYAHQEVPFERLVEVINPDRSMSRHPLFQVMLTL-------HNNPSAPFRLSGVEV 1412 Query 1397 LEPTFDAAQADLSVNFFACGDEY---------RGHVIYRTELYERATAQRFADWLVRVVE 1447 D A + F+ + Y G V Y +L++ TA+R A VRV+E Sbjct 1413 GTQRVDTQVAKFDL-LFSLRESYSADGRPGGVEGFVEYSKDLFDETTAERVAAAYVRVLE 1471 Query 1448 AFADRPDQPLREVEMVSAQARRRILDRSN 1476 P +P+ +E++ AR +L N Sbjct 1472 NVLAEPGRPVGRIEVLDPVARHELLVARN 1500 Score = 481 bits (1237), Expect = 7e-133, Method: Compositional matrix adjust. Identities = 429/1281 (34%), Positives = 584/1281 (46%), Gaps = 154/1281 (12%) Query 1 MWFVQMADPSGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDDGVAQPT 60 MWF+ + NI +S R+TG +D L+ A+ V RH LRTT+P D Sbjct 3179 MWFLNRLEGPSPTYNIPLSMRLTGPLDARALQAALGDVVARHESLRTTFPETD------- 3231 Query 61 VHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREF--------CAPFELSRDAPLRITVVR 112 G + ++ D + RLR+ + E F+L + P+R+ + Sbjct 3232 -------GKPRQEILDAATATPRLRIADVTPDELDAAVAGAVAYGFDLGAELPVRVHLFT 3284 Query 113 TAADEHVLLLVAHHIAWDDGSWRVFFTDLTQAYSRADLGADLGPEHRPSAASGPDTT--- 169 +HVL+ + HHIA D S DL+ AY RA + A P P A D Sbjct 3285 VGPRDHVLVFLVHHIASDGWSLGPLLRDLSDAY-RARV-AGRAPRWTPLAVQYADYAIWQ 3342 Query 170 --------------EADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTA 215 A+L+YWRA +A PE L LP S R LRL + Sbjct 3343 RDLLGSEDDQDSRLSAELSYWRAQLAGMPEELALPTDLPRPARPSHRGELVRLRLRPEPH 3402 Query 216 ARVATMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRGAGTEDA----IGYFG 271 + +AK TG +P+MVL AA AL+ R D V V R T+DA +G+F Sbjct 3403 RALVDLAKATGASPFMVLQAALAALLTRLGAGTDIPVGTTVAGR---TDDALDELVGFFV 3459 Query 272 NTVAMRLRPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSF 331 NT+ +R +FREL+ R A+ +Q + +R+V LNP R + +V Sbjct 3460 NTLVLRTDTSGDPTFRELVERARVTDVAAYENQNVPFERLVEVLNPSRSMSRHPLLQVML 3519 Query 332 GFREPDGGGFNPPGIECERYDLRSNITQLPLGFMV-EFDRAGVLVEA------------- 377 PP DL I Q P G V +FD A L E Sbjct 3520 NLLN------TPPAELSLGEDL--TIAQQPNGLRVAKFDLAFNLAETVDAAGGPDGVVGV 3571 Query 378 -EHLVEILEPALAKQMLRHFGVLLDNALAAPDNTLSGLALMDERDAARLREVSRGERFDT 436 E+ ++ + + LL+ LA PD L+ + L G Sbjct 3572 VEYSTDLFTHDTVQLLADRLITLLERMLAEPDRPTGEHDLLTGDERELLLGEWGGTAAPV 3631 Query 437 PVKTLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLL 496 P T +L Q TPDATA+ EG+ Y +L+ +NRL H L +GIG VAV + Sbjct 3632 PAGTFAELFEAQVEHTPDATALWCEGESIAYAELDRRANRLAHELTARGIGRGQVVAVAV 3691 Query 497 DKSPDLIVTALGVVKSGAVYVPVDPSYPQDRLDFILADCDAKLVLRT------------- 543 +SP + L V K+GAVY+PVDP YP +R+ ++L D +L T Sbjct 3692 PRSPQQVTAFLAVTKAGAVYLPVDPEYPAERVAYMLDDAAPAALLVTDAARGELPDEPAV 3751 Query 544 PVREL------AGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYF 597 PV L A + T P + AY+IYTSG+TG PKGV V H +A + Sbjct 3752 PVWALDDEAFAASVAARPATGPAGPGRPGPLSPAYVIYTSGSTGRPKGVLVSHTGLAPFV 3811 Query 598 VWFKGEYDVDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRD 657 + DR+LQV S +FDVS+ ++ TL GA + +P P L L Sbjct 3812 HSHVERLGLRTGDRVLQVVSTNFDVSVGDLAMTLLSGAALALPGPSRELVGDGLADALEA 3871 Query 658 EGITAMHFVPSLLGLFLSLPGVSQWRTLQRVPIGGEPL-PGEVADKFHATFDALLHNFYG 716 G T + LLG +LP L+ V GGE L PG VA ++ A + N YG Sbjct 3872 SGATHVMLPAPLLG---TLPEERPLPRLRCVVSGGEALSPGLVA-RWSAGRTVI--NAYG 3925 Query 717 PTETVINASRFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAY 776 PTET + A+ + P T PIGRP T + +LDD L+PVP GV GE++I G VA Sbjct 3926 PTETTVAATLSDPLSPDTTP--PIGRPVAGTRVLVLDDRLRPVPVGVAGELHIAGPGVAL 3983 Query 777 GYHRRAGLTAERFVADPFNP-GSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELG 835 GY R GLTAERFVADPF P GSRMYRSGDL R G +EFVGRAD+QVKIRGFR+E G Sbjct 3984 GYLGRPGLTAERFVADPFGPAGSRMYRSGDLVRWTTGGRLEFVGRADQQVKIRGFRVEPG 4043 Query 836 DVAAAIAVDPTVGQAVVVV-SDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAA 894 ++ + + QA V+V D P L + LV YV P +G P V +R VA A Sbjct 4044 EIETVLLARAGLAQAAVIVREDQPGL-RQLVAYVVPDSGAQMPEPV-----VLRKDVATA 4097 Query 895 LPEYMLPAAYVVLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLG 954 LP+YM+PAA+V LD +P+T++GK+DRAALP P+ + R P T E L ++F ELLG Sbjct 4098 LPDYMVPAAFVTLDALPLTSNGKLDRAALPVPEFDTGVPGRDPATEREETLCRIFAELLG 4157 Query 955 RDRVGADDSFFDLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDS 1014 R VG DDSFFDLGG S+++ +LV+ R A G+++ V ++FE T A + Sbjct 4158 RTAVGVDDSFFDLGGDSIVSIQLVSRARTA-GIELSVADVFEHRTPAA------LAEIAE 4210 Query 1015 ARPRLTRVDHDGPV-RLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITD 1073 A R D D + L + + W+ GP + AA D + A+ Sbjct 4211 AATRTLAEDPDAGIGELPLTPIVHWWR-EHGGPIDGFHQSMAAQTPAALDLDGLTTAVQA 4269 Query 1074 VVARHEILRT-VYREIGGVPHQIIQPPAEVP----------VRCAAGSDAAWLRA----- 1117 V+ RH+ LR + R ++P EV AA D RA Sbjct 4270 VIDRHDALRMRLTRGDADDWRTEVRPRGEVRAADLVHRVDFAEAAASGDTEAQRALVVEH 4329 Query 1118 ------ELNNERGYV-----FDLETDWPIRAALLSTPEQTVLSLVVHHIAGDHWSAGVLF 1166 L E G + FD D P +L VHH+ D S +L Sbjct 4330 GQAASRRLTPESGTLAQVVWFDAGPDRP-----------GLLLFAVHHLVVDGVSWRILL 4378 Query 1167 TDLLTAYRARSTGQRPSWAPL 1187 DL +A+ + G P P+ Sbjct 4379 PDLASAWSQVAAGDEPGLEPV 4399 Score = 93.6 bits (231), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 121/446 (28%), Positives = 177/446 (40%), Gaps = 48/446 (10%) Query 1058 LHGPCDTNAFAAAITDVVARHEILRTVYR------EIGGVPHQIIQPPAEVPVR-CAAGS 1110 L G D A A++ ++ RH LR +R + +P ++ P E +R Sbjct 41 LEGDLDVAAMRASVASLLERHPNLRAAFRYERLSRPVQLIPREVALPWQEFDLRDLPEEQ 100 Query 1111 DAAWLRAELNNERGYVFDLETDWPIRAALLSTPE-QTVLSLVVHHIAGDHWSAGVLFTDL 1169 A L E FDL + L+ E + L L HHI D WS G L TDL Sbjct 101 QAERLEEHTAAESERTFDLTRPPLLHFTLIHHGEGRHRLILAHHHILLDGWSVGRLMTDL 160 Query 1170 LTAYRARSTGQRPSWAPLPVQYADYSVWQSALLDDGAGIVGPQRDYWIRQLGGLAGETGL 1229 T Y A G S P Y DY W + A + W L G+ T L Sbjct 161 FTLYAA---GGDASGLPAVTPYRDYLAWLARQDRPAA------EEAWRTVLAGVEEPTRL 211 Query 1230 RPDFPRPALLSGAGDAVEFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVD 1289 P+ P A+ A + + + A + L +R +T + Q A AVVL + G D Sbjct 212 VPEGPEAAV---APERLLVEVPAELSRALTETARRHDLTLNTVFQGAWAVVLGRLTGRDD 268 Query 1290 VPIGAPVAGRSE--ANLDQLIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDL 1347 V G V+GR ++ +IG FIN + +R L + E+L R ++ AHQ L Sbjct 269 VVFGGTVSGRPADIPGVEDVIGLFINTLPVRVRLDPAEPVGEMLARFQRQQAGLMAHQHL 328 Query 1348 PFDQVVEAVNPQRSLSRNP--LFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQ 1405 + +L+ P LFD + V E P D + R L AA Sbjct 329 NLPDI-------HALAGAPGELFDTIT-VTENYPFD---------EKGFRELAGLTIAAA 371 Query 1406 ADLSVNFFAC------GDEYRGHVIYRTELYERATAQRFADWLVRVVEAFADRPDQPLRE 1459 N + G+ R YR +++ A + LVRV+EA P +P+ Sbjct 372 HGADANHYPLSVAALPGETLRFRFGYRPDVFGAADVEAIGARLVRVLEAVVREPGRPVGR 431 Query 1460 VEMVSAQARRRILDRSNA-GAGTARV 1484 +++++ R IL NA GA + R Sbjct 432 LDVLAGAEREEILHTRNATGAASPRT 457 Score = 69.3 bits (168), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 44/100 (44%), Positives = 58/100 (58%), Gaps = 4/100 (4%) Query 1479 AGTARVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLY 1538 AGT RV +LDD L+PVPVGV G+++ G L RP TA RFVADPF GSR+Y Sbjct 3952 AGT-RVLVLDDRLRPVPVGVAGELHIAGPGVALGYLGRPGLTAERFVADPFGPA-GSRMY 4009 Query 1539 RNGERGVWKADGQLELLAEIERLPTAQAAPVPAEPADTET 1578 R+G+ W G+LE + ++ + V EP + ET Sbjct 4010 RSGDLVRWTTGGRLEFVGRADQQVKIRGFRV--EPGEIET 4047 Score = 68.9 bits (167), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 35/71 (50%), Positives = 45/71 (64%), Gaps = 1/71 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 +VY+LD AL+PVP GV G++Y G RP TA RF ADPF A PG R+YR G+ Sbjct 1842 QVYVLDAALRPVPDGVTGELYIAGAQLARGYHHRPGLTAERFTADPFGA-PGGRMYRTGD 1900 Query 1543 RGVWKADGQLE 1553 W +DG+L+ Sbjct 1901 LVRWNSDGELD 1911 Score = 65.1 bits (157), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 35/73 (48%), Positives = 43/73 (59%), Gaps = 1/73 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RV++LD+AL+PVPVG G+ Y G RP TA RFVADP GSR+YR G+ Sbjct 2895 RVFVLDEALQPVPVGTPGEAYLAGDGLARGYAGRPGLTAERFVADPHGPA-GSRMYRTGD 2953 Query 1543 RGVWKADGQLELL 1555 W DG LE + Sbjct 2954 LVRWLPDGNLEFV 2966 Score = 64.7 bits (156), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 35/72 (49%), Positives = 44/72 (62%), Gaps = 1/72 (1%) Query 1483 RVYLLDDALKPVPVGVVGDVYYGGGPAVGARLARPSETATRFVADPFAAQPGSRLYRNGE 1542 RVY+LD AL+PV GV G++Y G L RP+ +A RFVADPF GSR+YR G+ Sbjct 775 RVYVLDAALRPVLPGVRGELYVAGSGLARGYLDRPALSAERFVADPFGPA-GSRMYRTGD 833 Query 1543 RGVWKADGQLEL 1554 W GQL+ Sbjct 834 VATWTDAGQLDF 845 Score = 57.4 bits (137), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/106 (41%), Positives = 55/106 (52%), Gaps = 12/106 (11%) Query 1550 GQLELLAEIERLPTAQ----AAPVP---AEPADT----ETERALAAILADVLEVGEVGRY 1598 G LLAE LP+ + A PVP PA E L + A+VL++ VG Sbjct 1990 GAFVLLAEFPLLPSGKLDRAALPVPETEVRPAGRGPRGPREEILCGLFAEVLQLPSVGVD 2049 Query 1599 DDFFNLGGDSILATQVAARARDG-GIPLTARMVFEHPVLCELAAAV 1643 DDFF LGG S+LAT++ +R R G+ L R VFE P + LA V Sbjct 2050 DDFFTLGGHSLLATKLVSRVRGALGVELAVRDVFEAPTVAALAPKV 2095 Score = 56.6 bits (135), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 31/65 (48%), Positives = 39/65 (60%), Gaps = 0/65 (0%) Query 1569 VPAEPADTETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARDGGIPLTAR 1628 VP TE E L I A++L VG D FF+LGGDSI++ Q+ +RAR GI L+ Sbjct 4135 VPGRDPATEREETLCRIFAELLGRTAVGVDDSFFDLGGDSIVSIQLVSRARTAGIELSVA 4194 Query 1629 MVFEH 1633 VFEH Sbjct 4195 DVFEH 4199 Score = 43.1 bits (100), Expect = 0.50, Method: Compositional matrix adjust. Identities = 25/66 (38%), Positives = 35/66 (54%), Gaps = 1/66 (1%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARARD-GGIPLTARMVFEHP 1634 T E L + A++L V D FF LGG S+LAT++ R R G+ + R +FE P Sbjct 962 TPQEEILCGLFAEILGASVVSIDDSFFELGGHSLLATRLVTRIRSVFGVQFSLRSLFEDP 1021 Query 1635 VLCELA 1640 + LA Sbjct 1022 SVAGLA 1027 Score = 42.0 bits (97), Expect = 1.1, Method: Compositional matrix adjust. Identities = 28/71 (40%), Positives = 38/71 (54%), Gaps = 5/71 (7%) Query 1576 TETERALAAILADVLEVGEVGRYDDFFNLGGDSILATQVAARAR---DGGIPLTARMVFE 1632 ETE L I +VL +V +FF LGG S+ AT++ +R R D +PL R FE Sbjct 3083 NETESRLRRIFEEVLHSEDVDVEANFFELGGHSLQATKLVSRIRSEFDAELPL--RDFFE 3140 Query 1633 HPVLCELAAAV 1643 HP + LA + Sbjct 3141 HPNVAGLAVLI 3151 >gi|54027007|ref|YP_121249.1| putative non-ribosomal peptide synthetase [Nocardia farcinica IFM 10152] gi|54018515|dbj|BAD59885.1| putative non-ribosomal peptide synthetase [Nocardia farcinica IFM 10152] Length=14474 Score = 848 bits (2190), Expect = 0.0, Method: Compositional matrix adjust. Identities = 572/1563 (37%), Positives = 808/1563 (52%), Gaps = 108/1563 (6%) Query 1 MWFVQMADP------SGALLNICVSYRITGDIDLARLRDAVNAVARRHRILRTTYPVGDD 54 MWF+ D + + NI + R+ G +D+A LR AV V RH LRT YP + Sbjct 3192 MWFLNRFDTGPDAGGAASTYNIPAAVRLRGLLDVAALRGAVADVVARHETLRTVYP-SHE 3250 Query 55 GVAQPTVHADLRPGWTQYDLTDLSQRAQRLRLEVLAQREFCAPFELSRDAPLRITVVRTA 114 GVA V R + D+ + +++ RL A F+++ + P+R+ + Sbjct 3251 GVAYQRVLPAAR-AIPEVDVVETAEQDLLGRLYDFVN----AGFDVTAEPPVRLRIYELG 3305 Query 115 ADEHVLLLVAHHIAWDDGSWRVFFTDLTQAY-----------SRADLG-ADLGPEHRPSA 162 ++VL LV HHIA D S R DL AY S D+ D R + Sbjct 3306 ERDYVLALVVHHIAADGFSMRPLVRDLMTAYVARTGNTEPGWSPLDVQYIDFALWQRETL 3365 Query 163 ASGPDTTE---ADLNYWRAIMADPPEPLELPGPAGTCVPTSWRAARATLRLPADTAARVA 219 D T L+YWR +AD P+ L L V S+RA R+P + R+ Sbjct 3366 GDEDDPTSLIAQQLDYWRTALADLPDELRLVHKPRPNV-ASYRAGTHRFRVPGELIDRLN 3424 Query 220 TMAKNTGCTPYMVLLAAFGALVHRYTHSDDFLVAAPVLNRG-AGTEDAIGYFGNTVAMRL 278 +A G T +MV+ AF L+ R + +DD + PV RG +D +G F NT+ +R Sbjct 3425 RVAHANGTTLFMVVHGAFATLLSRLSGADDIAIGIPVAGRGEQALDDLVGMFVNTLVLRT 3484 Query 279 RPQSAMSFRELLTATRDIASGAFAHQRINLDRVVRELNPDRRHGAERMTRVSFGFREPDG 338 + +A F +LL R+ AFAH + +R+V LNP R + +V F+ Sbjct 3485 QVDTATPFTDLLAQVRERDLAAFAHADVPFERLVEVLNPARSQARHPLFQVMLSFQNLGR 3544 Query 339 GGFNPPGIECE---------RYDLRSNITQLPLGFMVEFDRAGVLVEAEHLVEILEPALA 389 PG+ E ++DL+ ++++P G E D E + ++ + A Sbjct 3545 TSLELPGLTVEELGIDPPTAKFDLQLTLSEIP-GAEAEMD-----AELVYATDLFDAGYA 3598 Query 390 KQMLRHFGVLLDNALAAPDNTLSGLALMD--ERDAARLR----EVSRGERFDTPV----K 439 F +L AAP + + L+D ER+ R E + +PV Sbjct 3599 DAFAARFLRVLHGVAAAPTAAVGDIELLDTAERELVLRRWNDTEFAVDAALTSPVGDSAA 3658 Query 440 TLVDLVNEQTTRTPDATAVVYEGQHFTYHDLNEASNRLGHWLIEQGIGSEDRVAVLLDKS 499 TLV L Q RTPDA A+ +EG TY + +RL WL + G+G E VA+ + +S Sbjct 3659 TLVALFEAQVARTPDAVALTFEGTSLTYAEFASRVHRLARWLKDNGVGPESYVALGIRRS 3718 Query 500 PDLIVTALGVVKSGAVYVPVDPSYPQDRLDFIL----------ADCDAKLVLRTPVR--- 546 DL+V + +G YVP+DP P +R++ IL + D + L VR Sbjct 3719 LDLLVGMYAISAAGGAYVPIDPDNPAERIEHILETAGPVCVLTSGSDLDVTLSRQVRIDR 3778 Query 547 -ELAGYRSDDPTDADRIRPLRPDNTAYLIYTSGTTGLPKGVAVPHRPVAEYFVWFKGEYD 605 +L+GY TDADR RPLR NTAY+I+TSG+TG PKGVAV H + VW +Y Sbjct 3779 LDLSGYSDAPLTDADRHRPLRTGNTAYVIFTSGSTGRPKGVAVSHAAIVNRLVWGHAQYG 3838 Query 606 VDDTDRLLQVASPSFDVSIAEIFGTLACGARMVIPRPGGLTDIGYLTALLRDEGITAMHF 665 + D +LQ +FDVS+ E F L GAR+VI +P G D YL L+ DE IT HF Sbjct 3839 LAADDVVLQKTPATFDVSVWEFFWPLQVGARLVIAKPDGHRDPSYLAQLIIDEHITTAHF 3898 Query 666 VPSLLGLFLSLPGVSQWRTLQRVPIGGEPLPGEVADKFHATFDALLHNFYGPTETVINAS 725 VPS++ LF+ P ++ L+ V GE LP A + A LHN YGPTE + + Sbjct 3899 VPSMMSLFVVEPRAAECTGLRNVFASGEGLPAVTAQRLRELTGARLHNLYGPTEAGVEVT 3958 Query 726 RFKVVGPQGTRIVPIGRPKINTTMHLLDDSLQPVPTGVIGEIYIGGTHVAYGYHRRAGLT 785 F V T VPIG P NT +++LD L+PVP GV GE+Y+ G +AYGY R LT Sbjct 3959 -FHEVTDADTVTVPIGAPVFNTQVYVLDSRLRPVPVGVPGELYLAGAQLAYGYVTRPDLT 4017 Query 786 AERFVADPFNPGSRMYRSGDLARRNADGDIEFVGRADEQVKIRGFRIELGDVAAAIAVDP 845 ERFVADPF G RMYR+GDL ADG++E++GR D QVK+RG RIELG++ A+ P Sbjct 4018 TERFVADPFGHGVRMYRTGDLVAWTADGELEYLGRTDFQVKLRGLRIELGEIEGALTALP 4077 Query 846 TVGQAVVVVSDLPRLGKSLVGYVTPAAGGDGPADVGVDLDRIRARVAAALPEYMLPAAYV 905 V Q+VVVV R G LV Y+ + +D+D ++A ++ LP YM+PAA+V Sbjct 4078 AVSQSVVVVRHDERTGDQLVAYLI------AEPNYTIDVDAVKAALSTQLPAYMVPAAFV 4131 Query 906 VLDEIPITAHGKIDRAALPEPQIASDTEFRAPQTATERRLAQLFGELLGRDRVGADDSFF 965 VLD P+ A GK+DR ALPEP + T F+AP T ++ +A FG++LG DRVG DD FF Sbjct 4132 VLDAFPLNASGKLDRKALPEPTFEAKT-FQAPVTPVQQIVASAFGDVLGIDRVGLDDDFF 4190 Query 966 DLGGHSLLATKLVAAVRNAFGVDVGVREIFEFATVTALAGHIDTLDSDSARPRLTRVDHD 1025 LGG+SL+AT+L A + A + +R +FE +TV ALA +++ R LT + Sbjct 4191 ALGGNSLVATQLTARLGAALDTQIPLRTLFEASTVAALAAKVESATGQGGRAPLTAQERP 4250 Query 1026 GP-----------VRLSSSQMRSWFNYRFDGPNAVNNIPFAAALHGPCDTNAFAAAITDV 1074 P V LS +Q R WF RFD VNNIP A L G D A AAI DV Sbjct 4251 APVPLPDGQTAQLVPLSPAQQRMWFLNRFDNRTGVNNIPVAVRLTGALDAAALQAAIRDV 4310 Query 1075 VARHEILRTVYREIGGVPHQIIQPPAEVPVRCAA----GSDAAWLRAELNNERGYVFDLE 1130 VARHE LRTVY E+ G +Q + P E PV S+A EL + FD+ Sbjct 4311 VARHETLRTVYPEVDGEGYQRVLPADEAPVDLVTEWVPASEAPRRVVELASTW---FDVT 4367 Query 1131 TDWPIRAALLSTPEQT-VLSLVVHHIAGDHWSAGVLFTDLLTAYRARSTGQRPSWAPLPV 1189 + P RA LL+ E++ +L LV+HHI+ D +S L D++ AY R G+ P+WAPL V Sbjct 4368 AEIPFRATLLTLDERSNLLVLVMHHISADGFSLRPLLRDIVVAYTERVGGEAPNWAPLEV 4427 Query 1190 QYADYSVWQSALL---DDGAGIVGPQRDYWIRQLGGLAGETGLRPDFPRPALLSGAGDAV 1246 QYADY++WQ +L DD + Q YWI QL L + L D PRP + S AG Sbjct 4428 QYADYTLWQRGVLGAEDDPESVAAAQIAYWIEQLRDLPDQIELPADRPRPEVASNAGALH 4487 Query 1247 EFRLGAAIRDKLAAVSRDLGVTEFMLLQAAVAVVLHKAGGGVDVPIGAPVAGRSEANLDQ 1306 F + A + L V+R GVT FM++ AA+A + D+ IG P+AGR E LD Sbjct 4488 HFTVDAQLHRALEDVARAHGVTLFMVVHAALATWAARLSNSTDIAIGTPIAGRGERALDD 4547 Query 1307 LIGFFINIVVLRNDLRGNPTLREVLQRTRQMALAAYAHQDLPFDQVVEAVNPQRSLSRNP 1366 L+G F+N +VLRN++ ++L++ R+ LAA+AH D+PF+++V+ ++P RS + +P Sbjct 4548 LVGMFVNTLVLRNEIDLGAKFSDLLEQVRRTDLAAFAHADVPFERLVDVLSPARSQAHHP 4607 Query 1367 LFDIVVHVREQMPQDHVIDTGPDGDTTLRVLEPTFDAAQADLSVNFF---ACGDEYRGHV 1423 LF + + + + P D L +++ FDA A V A G Sbjct 4608 LFQVGLTFEAASATEAGTVSLPGLD--LDIVD--FDAGTAKFDVQLTVGEAAGGALAMSW 4663 Query 1424 IYRTELYERATAQRFADWLVRVVEAFADRPDQPLREVEMVSAQARRRILDR---SNAGAG 1480 Y TEL++ T FAD LVR++ + A+ P + +++++ R + R + A G Sbjct 4664 NYATELFDPETVAAFADRLVRILRSVAEDPAVVVGDIDLLGEPERLDVAQRWVSAGADGG 4723 Query 1481 TAR 1483 AR Sbjct 4724 AAR 4726 Lambda K H 0.321 0.138 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 4392258027648 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40