BLASTP 2.2.25+
Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
15,229,318 sequences; 5,219,829,388 total letters
Query= Rv2381c
Length=1004
Score E
Sequences producing significant alignments: (Bits) Value
gi|15609518|ref|NP_216897.1| polyketide synthetase MBTD (polyket... 1999 0.0
gi|15841893|ref|NP_336930.1| polyketide synthase, putative [Myco... 1999 0.0
gi|340627392|ref|YP_004745844.1| polyketide synthetase MBTD [Myc... 1998 0.0
gi|289762547|ref|ZP_06521925.1| polyketide synthetase mbtD [Myco... 1658 0.0
gi|126436056|ref|YP_001071747.1| acyl transferase domain-contain... 941 0.0
gi|108800433|ref|YP_640630.1| acyl transferase region [Mycobacte... 940 0.0
gi|120404804|ref|YP_954633.1| acyl transferase domain-containing... 834 0.0
gi|240169031|ref|ZP_04747690.1| MbtD protein [Mycobacterium kans... 775 0.0
gi|118465281|ref|YP_881231.1| MbtD protein [Mycobacterium avium ... 739 0.0
gi|342857510|ref|ZP_08714166.1| MbtD protein [Mycobacterium colo... 736 0.0
gi|254774737|ref|ZP_05216253.1| MbtD protein [Mycobacterium aviu... 731 0.0
gi|41408272|ref|NP_961108.1| MbtD [Mycobacterium avium subsp. pa... 729 0.0
gi|336458166|gb|EGO37149.1| acyltransferase family protein,phosp... 728 0.0
gi|315443742|ref|YP_004076621.1| acyltransferase family protein ... 721 0.0
gi|118473284|ref|YP_888784.1| polyketide synthetase mbtd [Mycoba... 721 0.0
gi|145223282|ref|YP_001133960.1| acyl transferase region [Mycoba... 719 0.0
gi|254819402|ref|ZP_05224403.1| MbtD protein [Mycobacterium intr... 716 0.0
gi|296170583|ref|ZP_06852166.1| mycobactin biosynthesis enzyme M... 687 0.0
gi|333990181|ref|YP_004522795.1| polyketide synthase MbtD [Mycob... 583 4e-164
gi|289746159|ref|ZP_06505537.1| polyketide synthetase mbtD [Myco... 436 8e-120
gi|54022732|ref|YP_116974.1| putative polyketide synthase [Nocar... 427 3e-117
gi|183983675|ref|YP_001851966.1| polyketide synthase MbtD [Mycob... 420 9e-115
gi|262200641|ref|YP_003271849.1| acyl transferase [Gordonia bron... 411 3e-112
gi|118618910|ref|YP_907242.1| polyketide synthase MbtD [Mycobact... 410 8e-112
gi|169629205|ref|YP_001702854.1| putative polyketide synthase Mb... 405 2e-110
gi|326383358|ref|ZP_08205045.1| putative polyketide synthase [Go... 384 7e-104
gi|317506260|ref|ZP_07964078.1| acyl transferase domain-containi... 358 3e-96
gi|152695|gb|AAA26495.1| ORF3 encoding modules 5 & 6 for 6-deoxy... 304 6e-80
gi|134097330|ref|YP_001102991.1| EryAIII erythromycin polyketide... 303 8e-80
gi|291009650|ref|ZP_06567623.1| EryAIII erythromycin polyketide ... 303 9e-80
gi|54778587|gb|AAV39552.1| EryAIII (morphed) [synthetic construct] 301 3e-79
gi|2506137|sp|Q03133.4|ERYA3_SACER RecName: Full=Erythronolide s... 288 3e-75
gi|10179854|gb|AAG13919.1|AF263245_15 megalomicin 6-deoxyerythro... 280 1e-72
gi|30313904|gb|AAO49807.1| polyketide synthase [Mycobacterium sm... 274 7e-71
gi|46976|emb|CAA39583.1| 6-deoxyerythronolide B synthase [Saccha... 267 6e-69
gi|227367|prf||1702361A polyketide synthase 267 7e-69
gi|291434986|ref|ZP_06574376.1| type I modular polyketide syntha... 260 8e-67
gi|296141979|ref|YP_003649221.1| Acyl transferase [Tsukamurella ... 256 1e-65
gi|45934795|gb|AAS79459.1| polyketide synthase subunit [Streptom... 249 2e-63
gi|10179852|gb|AAG13917.1|AF263245_13 megalomicin 6-deoxyerythro... 246 2e-62
gi|345012879|ref|YP_004815233.1| beta-ketoacyl synthase [Strepto... 244 6e-62
gi|59723044|gb|AAU93805.2| polyketide synthase modules 5 and 6 [... 244 7e-62
gi|326780641|ref|ZP_08239906.1| Mycocerosate synthase., 6-deoxye... 243 1e-61
gi|59723045|gb|AAU93807.2| polyketide synthase modules 1 and 2 [... 243 2e-61
gi|54778585|gb|AAV39550.1| EryAI (morphed) [synthetic construct] 242 2e-61
gi|134097327|ref|YP_001102988.1| EryAI erythromycin polyketide s... 241 6e-61
gi|291010105|ref|ZP_06568078.1| EryAI erythromycin polyketide sy... 241 6e-61
gi|416965|sp|Q03131.1|ERYA1_SACER RecName: Full=Erythronolide sy... 241 7e-61
gi|43336421|gb|AAS46345.1| NlmA7 [Streptomyces nanchangensis] 238 4e-60
gi|291009294|ref|ZP_06567267.1| EryAIII erythromycin polyketide ... 234 5e-59
>gi|15609518|ref|NP_216897.1| polyketide synthetase MBTD (polyketide synthase) [Mycobacterium
tuberculosis H37Rv]
gi|31793558|ref|NP_856051.1| polyketide synthetase MBTD (polyketide synthase) [Mycobacterium
bovis AF2122/97]
gi|121638260|ref|YP_978484.1| polyketide synthetase mbtD [Mycobacterium bovis BCG str. Pasteur
1173P2]
54 more sequence titles
Length=1004
Score = 1999 bits (5180), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1004/1004 (100%), Positives = 1004/1004 (100%), Gaps = 0/1004 (0%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA
Sbjct 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP
Sbjct 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC
Sbjct 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS
Sbjct 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
Query 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES
Sbjct 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
Query 301 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 360
LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC
Sbjct 301 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 360
Query 361 GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD 420
GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD
Sbjct 361 GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD 420
Query 421 PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP
Sbjct 421 PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
Query 481 VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA 540
VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA
Sbjct 481 VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA 540
Query 541 GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH 600
GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH
Sbjct 541 GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH 600
Query 601 PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS 660
PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS
Sbjct 601 PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS 660
Query 661 LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS 720
LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS
Sbjct 661 LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS 720
Query 721 PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM 780
PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM
Sbjct 721 PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM 780
Query 781 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 840
IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ
Sbjct 781 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 840
Query 841 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD 900
APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD
Sbjct 841 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD 900
Query 901 SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL
Sbjct 901 SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
Query 961 KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD
Sbjct 961 KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
>gi|15841893|ref|NP_336930.1| polyketide synthase, putative [Mycobacterium tuberculosis CDC1551]
gi|254232519|ref|ZP_04925846.1| polyketide synthetase mbtD [Mycobacterium tuberculosis C]
gi|308232116|ref|ZP_07414983.2| polyketide synthetase mbtD [Mycobacterium tuberculosis SUMu001]
17 more sequence titles
Length=1009
Score = 1999 bits (5179), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1004/1004 (100%), Positives = 1004/1004 (100%), Gaps = 0/1004 (0%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA
Sbjct 6 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 65
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP
Sbjct 66 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 125
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC
Sbjct 126 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 185
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS
Sbjct 186 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 245
Query 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES
Sbjct 246 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 305
Query 301 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 360
LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC
Sbjct 306 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 365
Query 361 GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD 420
GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD
Sbjct 366 GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD 425
Query 421 PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP
Sbjct 426 PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 485
Query 481 VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA 540
VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA
Sbjct 486 VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA 545
Query 541 GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH 600
GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH
Sbjct 546 GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH 605
Query 601 PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS 660
PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS
Sbjct 606 PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS 665
Query 661 LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS 720
LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS
Sbjct 666 LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS 725
Query 721 PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM 780
PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM
Sbjct 726 PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM 785
Query 781 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 840
IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ
Sbjct 786 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 845
Query 841 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD 900
APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD
Sbjct 846 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD 905
Query 901 SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL
Sbjct 906 SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 965
Query 961 KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD
Sbjct 966 KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1009
>gi|340627392|ref|YP_004745844.1| polyketide synthetase MBTD [Mycobacterium canettii CIPT 140010059]
gi|340005582|emb|CCC44744.1| polyketide synthetase MBTD (polyketide synthase) [Mycobacterium
canettii CIPT 140010059]
Length=1004
Score = 1998 bits (5177), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 1003/1004 (99%), Positives = 1004/1004 (100%), Gaps = 0/1004 (0%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA
Sbjct 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP
Sbjct 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC
Sbjct 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS
Sbjct 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
Query 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES
Sbjct 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
Query 301 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 360
LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC
Sbjct 301 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 360
Query 361 GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD 420
GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD
Sbjct 361 GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD 420
Query 421 PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP
Sbjct 421 PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
Query 481 VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA 540
VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELIL+IAPDFEHTDAVRAA
Sbjct 481 VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILLIAPDFEHTDAVRAA 540
Query 541 GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH 600
GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH
Sbjct 541 GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH 600
Query 601 PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS 660
PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS
Sbjct 601 PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS 660
Query 661 LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS 720
LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS
Sbjct 661 LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS 720
Query 721 PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM 780
PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM
Sbjct 721 PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM 780
Query 781 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 840
IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ
Sbjct 781 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 840
Query 841 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD 900
APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD
Sbjct 841 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD 900
Query 901 SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL
Sbjct 901 SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
Query 961 KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD
Sbjct 961 KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
>gi|289762547|ref|ZP_06521925.1| polyketide synthetase mbtD [Mycobacterium tuberculosis GM 1503]
gi|289710053|gb|EFD74069.1| polyketide synthetase mbtD [Mycobacterium tuberculosis GM 1503]
Length=853
Score = 1658 bits (4294), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 831/831 (100%), Positives = 831/831 (100%), Gaps = 0/831 (0%)
Query 174 AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG 233
AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG
Sbjct 23 AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG 82
Query 234 IGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPV 293
IGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPV
Sbjct 83 IGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPV 142
Query 294 HTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRA 353
HTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRA
Sbjct 143 HTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRA 202
Query 354 VESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANI 413
VESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANI
Sbjct 203 VESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANI 262
Query 414 VSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWE 473
VSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWE
Sbjct 263 VSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWE 322
Query 474 RMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEH 533
RMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEH
Sbjct 323 RMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEH 382
Query 534 TDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMH 593
TDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMH
Sbjct 383 TDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMH 442
Query 594 RSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADA 653
RSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADA
Sbjct 443 RSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADA 502
Query 654 PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ 713
PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ
Sbjct 503 PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ 562
Query 714 HGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAK 773
HGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAK
Sbjct 563 HGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAK 622
Query 774 VLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVA 833
VLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVA
Sbjct 623 VLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVA 682
Query 834 VKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAA 893
VKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAA
Sbjct 683 VKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAA 742
Query 894 RLQMLLDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLA 953
RLQMLLDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLA
Sbjct 743 RLQMLLDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLA 802
Query 954 LDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
LDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD
Sbjct 803 LDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 853
>gi|126436056|ref|YP_001071747.1| acyl transferase domain-containing protein [Mycobacterium sp.
JLS]
gi|126235856|gb|ABN99256.1| acyl transferase domain protein [Mycobacterium sp. JLS]
Length=978
Score = 941 bits (2433), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 560/1014 (56%), Positives = 683/1014 (68%), Gaps = 51/1014 (5%)
Query 3 PKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
P + PDGR+ VLLSAHA +L+ DARA+ YL+ PA +V +VA L TRRVRRHR V+
Sbjct 4 PNRWPDGRIPVLLSAHAGDLVAEDARAVLGYLDHDPAASVADVAGHLLTTRRVRRHRTVV 63
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTY 122
RA DR ELA+GLRA+A G EHPL+A S+ GS R AFVFPGQG WP MG AY ELP Y
Sbjct 64 RAGDRDELADGLRAVAEGAEHPLVACSAEGSPSRIAFVFPGQGTQWPSMGTQAYEELPQY 123
Query 123 RTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGV 182
R A D CA AF AAG SP+ YL P GT E F E EIEGAQF HAVALA VWRS GV
Sbjct 124 RAAADACAEAFTAAGAASPMRYLTTP-GTAEE--FSEAEIEGAQFTHAVALAHVWRSYGV 180
Query 183 LPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASAL 242
LPD+TVGHSLGE+ AAYLAG+ITL+DAVAVV ARA VV RL G +AVA LG+ + A +
Sbjct 181 LPDITVGHSLGEIGAAYLAGAITLADAVAVVIARAEVVDRLSGDHAVAVLGVDPETAQQV 240
Query 243 IATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLR 302
IA T GWLELSVVNA+++VAVSG+R+AV+A V VR G FAR ITVGFPVHTS+LE LR
Sbjct 241 IAATPGWLELSVVNAATSVAVSGDRRAVSAAVALVREQGRFAREITVGFPVHTSILEPLR 300
Query 303 DELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGA 362
D+ +QLP + F + PVQFIGG TGDVV G FGDYWYANLR VRFD A ESA RCGA
Sbjct 301 DDFVKQLPQAVFADTPVQFIGGATGDVVPAGAMFGDYWYANLRTMVRFDHAFESARRCGA 360
Query 363 RAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPG 422
F+E+SAHP LLFA+G L D A LVGS RR +ALS N+ AA++DPG
Sbjct 361 TTFVELSAHPQLLFAMGD------LLGDTTATLVGSGRRDTPITEALSDNLAVAAISDPG 414
Query 423 YPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVA 482
+ W D +P L GFPNAPMRA P+WA PEPL + +T+A E W+ + TP A
Sbjct 415 HGWRD-AVEPTAH--RLRGFPNAPMRATPLWAQPEPLSETADITVAQEVWQPIDDVTPSA 471
Query 483 GRHRHLA-----VLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV 537
H A VL+LGA + L A+D+HP L A++++V+AP DA
Sbjct 472 ----HTAPVTVTVLELGATGPFGERLRTAVDAHPGMALGTPDTADVMVVVAPQPGGADAK 527
Query 538 RAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIG 597
A + DLVG+G L YP G RC+ + LVT GAE+V + + AA+AAMHRS+G
Sbjct 528 TAVTTVTDLVGSGALRYPASAGPRCRDIWLVTAGAERVRTGEP-QALSAAAIAAMHRSLG 586
Query 598 FEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVP 657
E+PE F HLDLP+ DP + +V+ +L G GE A+RG +G L+ RT+ADAP P
Sbjct 587 LENPELGFHHLDLPA---DPTIDTAVVDTLLTGAGERAIRGG-DGPVLYRRTVADAPVAP 642
Query 658 NWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTV 717
WSLDSG+LD+VV+TGGAG IG+HYAR+LAE GARRIVLLSRRA D A +A L GT
Sbjct 643 AWSLDSGILDEVVITGGAGRIGLHYARHLAERGARRIVLLSRRAVDPAVLAELTAARGTE 702
Query 718 IVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGL 777
+VS PCD+TD + A ++ G+GASL++HAAG+ + + +AA V+ AKV GL
Sbjct 703 VVSVPCDLTDRESIR-TATDFAGIGASLVIHAAGAATFASGDRLDAAAAVNTLGAKVTGL 761
Query 778 AQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWG 837
A + +LWPL PD R +LCSSV G+WGGHG YSAANR+LD MA +LRA G CV+V+WG
Sbjct 762 AHLADLWPLHPDARIVLCSSVSGLWGGHGHAVYSAANRMLDAMAGRLRADGHRCVSVRWG 821
Query 838 LWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQM 897
LW++ +GE GI A AR+ERSGLR MAP AIEASL + TVDPLVF+AD R+QM
Sbjct 822 LWRS-DSGE---GIVGAAETARIERSGLRPMAPLPAIEASLCDHTVDPLVFSADPHRMQM 877
Query 898 L-------LDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDS 950
D + E P D DAVR +LAAVL I G ++L SLFDLGVDS
Sbjct 878 FSAATEPVRDPQTAETTAAPVD----TADAVRAELAAVLKITDPGGIDLDASLFDLGVDS 933
Query 951 MLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
+LALDLR R +R +G TV LATL+G +TG LVA+L+ +KV+I RD
Sbjct 934 LLALDLRKRFRRVLGRTVPLATLLGGVTGAELVAELD---------EKVEIPRD 978
>gi|108800433|ref|YP_640630.1| acyl transferase region [Mycobacterium sp. MCS]
gi|119869562|ref|YP_939514.1| acyl transferase domain-containing protein [Mycobacterium sp.
KMS]
gi|108770852|gb|ABG09574.1| acyl transferase region [Mycobacterium sp. MCS]
gi|119695651|gb|ABL92724.1| acyl transferase domain protein [Mycobacterium sp. KMS]
Length=978
Score = 940 bits (2430), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 561/1014 (56%), Positives = 682/1014 (68%), Gaps = 51/1014 (5%)
Query 3 PKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
P + PDGR+ VLLSAHA +L+ DARA+ YL+ PA +V +VA L TRRVRRHR V+
Sbjct 4 PNRWPDGRIPVLLSAHAGDLVAEDARAVLGYLDHDPAASVADVAGHLLTTRRVRRHRTVV 63
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTY 122
RA DR ELA+GLRA+A G EHPL+ARS+ GS R AFVFPGQG WP MG AY ELP Y
Sbjct 64 RAGDRDELADGLRAVAHGAEHPLVARSAEGSPSRIAFVFPGQGTQWPSMGTQAYEELPQY 123
Query 123 RTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGV 182
R A D CA AF AAG SP+ YL P GT E F E EIEGAQF HAVALA VWRS GV
Sbjct 124 RAAADACAEAFTAAGAASPMRYLTTP-GTAE--GFSEAEIEGAQFTHAVALAHVWRSYGV 180
Query 183 LPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASAL 242
LPD+TVGHSLGE+ AAYLAG+ITL+DAVAVV ARA VV RL G +AVA LG+ + A +
Sbjct 181 LPDITVGHSLGEIGAAYLAGAITLADAVAVVIARAEVVDRLSGDHAVAVLGVDPETAQQV 240
Query 243 IATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLR 302
IA T GWLELSVVNA+++VAVSG+R+AV+A V VR G FAR ITVGFPVHTS+LE LR
Sbjct 241 IAATPGWLELSVVNAATSVAVSGDRRAVSAAVARVREQGRFAREITVGFPVHTSILEPLR 300
Query 303 DELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGA 362
D+ +QLP + F ++PVQFIGG TGDVV G FGDYWYANLR VRFDRA ESA RCGA
Sbjct 301 DDFVKQLPQAVFADSPVQFIGGATGDVVPAGAMFGDYWYANLRTMVRFDRAFESARRCGA 360
Query 363 RAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPG 422
F+E+SAHP LLFA+G L D A LVGS RR +ALS N+ AAV+DPG
Sbjct 361 TTFVELSAHPQLLFAMGD------LLGDTTATLVGSGRRDTPITEALSDNLAVAAVSDPG 414
Query 423 YPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVA 482
+ W D L GFPNAPMRA P+WA PEPL + +T+A E W+ + TP A
Sbjct 415 HGWRDAVERTAH---RLRGFPNAPMRATPLWAQPEPLSETADITVAQEVWQPIDDVTPSA 471
Query 483 GRHRHLA-----VLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV 537
H A VL+LGA + L A+D+HP L A++++V+AP DA
Sbjct 472 ----HTAPVTVTVLELGATGPFGERLRTAVDAHPGMALGTPDTADVMVVVAPQPGGADAK 527
Query 538 RAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIG 597
A + DLVG+G L YP G RC+ + LVT GAE+V A + + AA+AAMHRS+G
Sbjct 528 TAVTTVTDLVGSGALRYPASAGPRCRDIWLVTAGAERVRAGEP-QALSAAAIAAMHRSLG 586
Query 598 FEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVP 657
E+PE F HLDLP+ DP + +V+ +L G GE A+RG +G L+ RT+ADAP P
Sbjct 587 LENPELGFHHLDLPA---DPTIDTAVVDTLLTGAGELAIRGG-DGPVLYRRTVADAPVAP 642
Query 658 NWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTV 717
WSL SG+LD+VV+TGGAG IG+HYAR+LAE GARRIVLLSRRA D A +A L GT
Sbjct 643 AWSLGSGILDEVVITGGAGRIGLHYARHLAERGARRIVLLSRRAVDPAVLAELTAPRGTE 702
Query 718 IVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGL 777
+VS PCD+TD + A ++ G+GASL++HAAG+ + +AA V+ AKV GL
Sbjct 703 VVSVPCDLTDRESIR-TATDFAGIGASLVIHAAGAATFAEGDRLDAAAAVNTLGAKVTGL 761
Query 778 AQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWG 837
A + +LWPL PD R +LCSSV G+WGGHG YSAANR+LD MA +LRA G CV+V+WG
Sbjct 762 AHLADLWPLHPDARIVLCSSVSGLWGGHGHAVYSAANRMLDAMAGRLRADGHRCVSVRWG 821
Query 838 LWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQM 897
LW++ +GE GI A AR+ERSGLR MAP AIEASL + TVDPLVF+AD R+QM
Sbjct 822 LWRS-DSGE---GIVGAAETARIERSGLRPMAPLPAIEASLCDHTVDPLVFSADPHRMQM 877
Query 898 L-------LDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDS 950
D + E P D DAVR +LAAVL I G ++L SLFDLGVDS
Sbjct 878 FSAATEPVRDPQTAETTAAPVD----TADAVRAELAAVLKITDPGGIDLDASLFDLGVDS 933
Query 951 MLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
+LALDL R +R +G TV LATL+G +TG LVA+L+ +KV+I RD
Sbjct 934 LLALDLGKRFRRVLGRTVPLATLLGGVTGAELVAELD---------EKVEIPRD 978
>gi|120404804|ref|YP_954633.1| acyl transferase domain-containing protein [Mycobacterium vanbaalenii
PYR-1]
gi|119957622|gb|ABM14627.1| acyl transferase domain protein [Mycobacterium vanbaalenii PYR-1]
Length=972
Score = 834 bits (2154), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 524/1012 (52%), Positives = 665/1012 (66%), Gaps = 48/1012 (4%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
M+ +LPDGRVAV LSAH E L+ AR I +L+R P+ +VA QL +TRR+RRHRA
Sbjct 1 MSAGRLPDGRVAVPLSAHHEALVSATARDILGHLQRNPSEP-GQVAAQLVRTRRLRRHRA 59
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
++RA DR ELA GL+A+A R+HPL+ARS+ + R AFVFPGQG WPGMG AYR LP
Sbjct 60 IVRAGDRDELAAGLQAVADDRDHPLVARSAGRAGARTAFVFPGQGSQWPGMGGEAYRLLP 119
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
YR D AF AAG+ SPLP+L A + + + +++ AQFVH+VALA VWRSC
Sbjct 120 VYRAEADRLTEAFLAAGLTSPLPFLTA---DTDGEPVSQYDLQAAQFVHSVALAAVWRSC 176
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
G++PDLTVGHSLGEVAAAY+A ++TL DAV V+AARA + +PG VA LG+ +A+
Sbjct 177 GIVPDLTVGHSLGEVAAAYVAETVTLVDAVTVLAARAAAIEAIPGDNGVAVLGVDATEAA 236
Query 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
LIA TGGWLELS VNA ++VAVSGER AVAAI R+ G FA+ + + FP HT+ +E+
Sbjct 237 ELIAATGGWLELSAVNAQNSVAVSGERSAVAAIAAAARARGRFAKELAMSFPAHTTAMET 296
Query 301 LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC 360
R++L +LP S F ++PVQF+G TG +V GT FG YWYANLR+T+RFD+AV++AI
Sbjct 297 QREQLVRRLPTSVFADSPVQFVGSATGQLVRAGTEFGAYWYANLRNTIRFDQAVQTAIGL 356
Query 361 GARAFIEISAHPALLFAIGQNCE--GAANLPDGPAVLVGSARRGERFVDALSANIVSAAV 418
GA ++E+SAHP+LLFA+ E GAA AVLVGS R E D LSANIV+AA
Sbjct 357 GAGVYVELSAHPSLLFAVEDGIERVGAAA-----AVLVGSGHRDESVPDRLSANIVTAAA 411
Query 419 ADPGYPWGDLGGDPLDGDVD-LSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVP 477
ADP Y WGDL L G+ + L GFP APMRA +WA PEPLP GLT+ E W + P
Sbjct 412 ADPAYRWGDL----LTGEPEPLFGFPGAPMRAEHLWAEPEPLPVAPGLTVTTETWRQRRP 467
Query 478 STPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV 537
A R +AV++ G+ A++++L AID D ++ A DA+L +V+AP F DA
Sbjct 468 RRVSAKVSRRVAVIESGSGTAISRSLRQAIDRRADLSVAGAADADLAIVVAPTFAGADAA 527
Query 538 RAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIG 597
L+ + GLL Y G RC+ V LVTVGAE V A D P GQA +AA+HR IG
Sbjct 528 GCVNELSGAIDTGLLGYADTFGPRCRDVWLVTVGAENVTAEDPAPDLGQAGVAALHRCIG 587
Query 598 FEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLA-DAPAV 656
FEHP+Q+F HLDLP+ D + V V+ + G GE ALR ++ERTL D
Sbjct 588 FEHPDQSFHHLDLPAGATDALGAVDVM---VDGAGELALR---RDGQVYERTLGDDTSTA 641
Query 657 PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGT 716
P W L SG LD+VV+TGG+GAIG+ +AR+LA GARRIVLLSRR A A + L G
Sbjct 642 PPWDLSSGTLDNVVITGGSGAIGLSFARFLAARGARRIVLLSRRGAGPAPLDNL----GA 697
Query 717 VIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLG 776
I++P CD+ DP QL+A AE+ G ASLI+HAAG+ +T AA+ D AK++G
Sbjct 698 EIIAPACDLRDPRQLAATVAEFAGGPASLIIHAAGTATFANRADITGAALADMAGAKIIG 757
Query 777 LAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKW 836
L + WP+R D R LLCSSV GVWGG GV Y+AANR+LDVMAA+L A GR+C AV++
Sbjct 758 LEALTRTWPIRDDARILLCSSVTGVWGGKGVGGYAAANRMLDVMAARLGADGRNCTAVRF 817
Query 837 GLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQ 896
GLW+ GI DA IARVER+GLRQM P+ A+EASL +F DPLV AAD R++
Sbjct 818 GLWE-------GSGIVDAAEIARVERTGLRQMKPELAVEASLCDFPRDPLVLAADRDRMR 870
Query 897 MLLDSRQFER----YEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSML 952
M + E+ G ++ DAVRTQLAAVL + A ++L LFDLGVDS+L
Sbjct 871 MFFGEKPVEKPGEADTGAGPASMAPPDAVRTQLAAVLDV-DAAALDLDSPLFDLGVDSLL 929
Query 953 ALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD 1004
ALDLR RLKR G TV LATL+G ITG L+A L ++KV+ S D
Sbjct 930 ALDLRKRLKRLTGHTVPLATLLGGITGADLIAGL---------SEKVNTSSD 972
>gi|240169031|ref|ZP_04747690.1| MbtD protein [Mycobacterium kansasii ATCC 12478]
Length=1038
Score = 775 bits (2000), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 510/1031 (50%), Positives = 640/1031 (63%), Gaps = 71/1031 (6%)
Query 2 APKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTE-----VARQLRKTRRVR 56
A +LPD RV VLLSAH EELIG DA AI DYLE T+ VA L +TRRVR
Sbjct 3 ATHRLPDNRVPVLLSAHEEELIGQDAAAILDYLEHLATQPGTDDVTPAVAATLLRTRRVR 62
Query 57 RHRAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAY 116
RHRAV+RAADR +L GLRALAAG HPL+ARSS + R AF FPGQG WP MGA AY
Sbjct 63 RHRAVVRAADRADLESGLRALAAGERHPLVARSSENANTRTAFAFPGQGNQWPSMGAQAY 122
Query 117 RELPTYRTATDTCAAAFAAAGVDSPLPYLIA--PPGTDER--QAFCEIEIEGAQFVHAVA 172
+ LP YR D CA AFAAAG+ SPLPYL+ P G+ + +I+I+GAQF HA +
Sbjct 123 QCLPAYRAEADRCAQAFAAAGLPSPLPYLLGELPAGSSAHTDHGWSQIDIQGAQFTHAAS 182
Query 173 LAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAAL 232
LA++WRSCGVLPDL++GHSLGE AAAY+AG+ITL+DAVAVVAARA VVGRL GRY +A L
Sbjct 183 LAQLWRSCGVLPDLSIGHSLGEAAAAYVAGTITLADAVAVVAARATVVGRLSGRYGMAVL 242
Query 233 GIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFP 292
+G A LIA T GWLE+S VN+ S+ VSG+R AVAAIV G FAR +TV +P
Sbjct 243 SMGADRAERLIAETPGWLEVSAVNSPSSSVVSGDRDAVAAIVGRAEKDGIFARELTVDYP 302
Query 293 VHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDR 352
HTS LESLRD L E LP S+F++APV+F+ GDVV P T F DYWY NLR+TVRFD+
Sbjct 303 GHTSKLESLRDTLRELLPASKFLDAPVEFVSSARGDVVTPDTDFTDYWYQNLRNTVRFDQ 362
Query 353 AVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSAN 412
A +A + GA F+E+SAHP+L +A+ + E A+++GS RR E V+ LSA+
Sbjct 363 AAVTARQRGAGTFVEMSAHPSLRYALAELAED--------ALILGSGRRDEPVVEHLSAS 414
Query 413 IVSAAVADPGYPWGDLGG---DPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSG--LTI 467
I +AAVA+PGY W D+ G PL L GFP APMRAV +WA PEPLPP G L +
Sbjct 415 IAAAAVANPGYRWSDVAGVGDQPL-----LRGFPTAPMRAVHLWATPEPLPPAPGSALVV 469
Query 468 AVERWERM------------VPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTEL 515
A ERWE++ P+T VA + D R LA+ L A+ +HP L
Sbjct 470 AYERWEQLPAHDQGQHGAADRPATAVA-----IVTPDSAGDR-LARRLTEAVRAHPACAL 523
Query 516 SAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQV 575
+ +AE+ ++IAP DAV AAG L GA LDY +G RC+ V LVT+ EQV
Sbjct 524 TGPAEAEIAVIIAPALLQPDAVAAAGQLRS--GAKQLDYHQAVGPRCRRVWLVTMCGEQV 581
Query 576 DAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETA 635
DA + QAALAAMHRS+GFE P+QTF+HLD+P ++D I +L E A
Sbjct 582 DARAPLALPAQAALAAMHRSVGFEFPDQTFAHLDVPGREIDEATARRCIDVLLDDHTEVA 641
Query 636 LRGSVNGYTL--FERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARR 693
+R +G L F RTL + +D+ LD VV+TGG G IG+ YAR+ EHGARR
Sbjct 642 VRAHDSGTGLDSFVRTLRQSAESAPEGVDAAALDHVVITGGNGTIGLRYARHCVEHGARR 701
Query 694 IVLLSRRAADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSV 753
+ LLSR + D+ + L + + +P CDITD LSA+A EY G GASL++HAAG+
Sbjct 702 VTLLSRNSVDRDELDRLTAGYPAQVHAPACDITDADALSAVAGEYAGDGASLLIHAAGAA 761
Query 754 ISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAA 813
+ D F+AKV GL +M + WPLRPD R LLCSSV GVWGG+G Y+A+
Sbjct 762 RFAPHDQLGGLEWADVFSAKVTGLVRMTDAWPLRPDARILLCSSVSGVWGGYGHAGYAAS 821
Query 814 NRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQA 873
NR+LD +AAQLR G +C++V+WGLWQ IA A +AR+ERSGL M P A
Sbjct 822 NRMLDTVAAQLRGNGLNCMSVRWGLWQGTT-------IAGADDVARIERSGLIAMDPDAA 874
Query 874 IEASLHEFTVDPLVFAADAARLQMLLDSR-------QFERYEGPTDP--------NLTIV 918
I L DPL+ AAD RL++ +S+ E D I
Sbjct 875 ITTGLGCRQGDPLILAADFDRLRVFFESQGAAMPFTSTTTAESDDDSAADSRSPDQRPIS 934
Query 919 DAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDIT 978
+ VR ++AA + V+L +L DLG DSMLALDLR+RL+R G +V A L+G IT
Sbjct 935 ELVRAEIAAAFSLDGPAAVDLNVALVDLGADSMLALDLRDRLRRWTGQSVPAARLLGGIT 994
Query 979 GDGLVAKLEDA 989
G L+A L+ A
Sbjct 995 GAELIAILQSA 1005
>gi|118465281|ref|YP_881231.1| MbtD protein [Mycobacterium avium 104]
gi|118166568|gb|ABK67465.1| MbtD protein [Mycobacterium avium 104]
Length=1013
Score = 739 bits (1908), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 473/1006 (48%), Positives = 606/1006 (61%), Gaps = 48/1006 (4%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATT--VTEVARQLRKTRRVRRH 58
M LPDGR+ VLLS+H ELI DA AI +YL+R +T VA L + RRVRRH
Sbjct 2 MPTHGLPDGRIPVLLSSHDPELIRRDAAAILEYLDRIGESTEATGAVAATLLRLRRVRRH 61
Query 59 RAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRE 118
RA+LRAADR ELA GL A+A G EH LI RS+ + PR AFVFPGQG W MGA AYR
Sbjct 62 RALLRAADRAELAAGLAAIARGEEHALITRSARTTPPRIAFVFPGQGNQWQAMGADAYRR 121
Query 119 LPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWR 178
LP YR A D CA AF AAG SPLPYL++P + Q++ EI+GAQF HAVALAE WR
Sbjct 122 LPAYREAADRCAQAFVAAGFPSPLPYLVSP----DEQSWTRPEIQGAQFTHAVALAEAWR 177
Query 179 SCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQD 238
GVLP++ +GHSLGEVAAAY+A +I+L DAVA+V ARA VV RL GRYA+A LG G D
Sbjct 178 CFGVLPEMAIGHSLGEVAAAYVAEAISLPDAVALVVARATVVDRLTGRYAMAVLGAGAAD 237
Query 239 ASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVL 298
A +L+ATT GW+E+S VN ++ V+G+ AVAA V + FA + V +P HTS L
Sbjct 238 AESLLATTPGWVEVSAVNGPASTVVAGDHDAVAAAVRLAQQREIFAHQLFVDYPGHTSAL 297
Query 299 ESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAI 358
LR L E P S F ++P++FIG T G VA T + YWY NL TVRFD AV+ A
Sbjct 298 RPLRAALAELTPQSAFRDSPIRFIGSTRGAEVAATTDYASYWYENLCSTVRFDLAVQCAR 357
Query 359 RCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAV 418
CGA AF+E+SAHP+LL+ + + + D AV+VGS R ++LSA++ + A
Sbjct 358 SCGADAFVELSAHPSLLYPL------SGIIDDESAVIVGSGHRDRPITESLSASMAAVAT 411
Query 419 ADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLP---PVSGLTIAVERWERM 475
ADPGY W + P L GFPNAPMRA +WA P+ + P LT+AVE W
Sbjct 412 ADPGYRWSETV--PTRNQPALHGFPNAPMRATHLWAAPDRVTEAAPRPRLTVAVEDWRHT 469
Query 476 VPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTD 535
T A GAH + + L A + + A +AE++ ++AP+ + D
Sbjct 470 TSPTTPTAADLGFA----GAH-PMTRRLADAAAAQGGCRVVAPGEAEIVAIVAPELDQLD 524
Query 536 AVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRS 595
AV A + AGL DY IG RC++V L+TV AE VD D QAALAAMHRS
Sbjct 525 AVAAVEQIGAREDAGLPDYRGLIGPRCRAVWLLTVRAEHVDGDDDQACVAQAALAAMHRS 584
Query 596 IGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPA 655
IGFE P+Q F H+DLP D+D ++I +L E ALRG + RT
Sbjct 585 IGFEFPDQAFGHVDLPHRDVDAATAYAIIEVLLAEPAEVALRGEQSPRRHV-RTFRAHHE 643
Query 656 VPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHG 715
+ LD L+ VV+TGG+GAIG+HYARY + GAR + LLSR + A + L H
Sbjct 644 SADRPLDDAALEHVVITGGSGAIGLHYARYCLQRGARNLTLLSRNGIEAAVLRELTGSHD 703
Query 716 TVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVL 775
+ +P CDITD ++ AA Y G GA+L++H AG + + +T A V AAKV
Sbjct 704 ARVSAPRCDITDRAAVTEAAARYAGSGATLLIHTAGIAQARSRTDLTGADVAAVCAAKVR 763
Query 776 GLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVK 835
GLA M ++WPLRPD R L CSSV GVWGG+ AY+A+NR+LDV+A QLRA+G C A++
Sbjct 764 GLALMADVWPLRPDCRILACSSVFGVWGGYHHAAYAASNRMLDVLATQLRARGLDCTAIR 823
Query 836 WGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARL 895
WGLWQ G+ IAR ERSGL M P++A++ASLH + DPL+F AD RL
Sbjct 824 WGLWQDA-------GVVAGSEIARTERSGLVAMDPRRALQASLHRYESDPLIFDADFERL 876
Query 896 QMLLDS------------RQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESL 943
Q+ +S R E P L V VR +LAA L + + ++ SL
Sbjct 877 QVFFESQGMPMPFSDTPTRDDEAAAAPAGKPLAEV--VRAELAATLHLGDSVSIDPSASL 934
Query 944 FDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA 989
DLGVDS+LALDLR RL+R++G +V +A ++G IT VA+L DA
Sbjct 935 IDLGVDSLLALDLRKRLRRTVGNSVPVARMLGGIT----VAELVDA 976
>gi|342857510|ref|ZP_08714166.1| MbtD protein [Mycobacterium colombiense CECT 3035]
gi|342134843|gb|EGT88009.1| MbtD protein [Mycobacterium colombiense CECT 3035]
Length=1014
Score = 736 bits (1900), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 476/1003 (48%), Positives = 609/1003 (61%), Gaps = 52/1003 (5%)
Query 6 LPDGRVAVLLSAHAEELIGPDARAIADYLERF--PATTVTEVARQLRKTRRVRRHRAVLR 63
LPDGRV V LSAH ELI DA AIADY+ R A VA L + RR+RRHRAVLR
Sbjct 6 LPDGRVPVTLSAHDPELIRRDAAAIADYVGRIDDSADPTAAVASTLLRLRRMRRHRAVLR 65
Query 64 AADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYR 123
AADR EL L A+A G EH L++RS+ + PR AFVFPGQG W MGA AYR LP YR
Sbjct 66 AADRTELVAALSAIARGDEHQLVSRSAKTTPPRIAFVFPGQGNQWQAMGAEAYRRLPAYR 125
Query 124 TATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVL 183
A D CA AF + G SPLPYL+ D + + EI+GAQF HAV+LAE WRSCG+L
Sbjct 126 EAADRCAQAFTSGGFPSPLPYLVG----DGERVWSRPEIQGAQFTHAVSLAEAWRSCGLL 181
Query 184 PDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALI 243
PD+T+GHSLGEVAAAY+A +I+L DAVA+V ARA+VV +L GRYA+A LG G A AL+
Sbjct 182 PDMTIGHSLGEVAAAYVAEAISLPDAVALVVARASVVDQLTGRYAMAVLGTGLDIAEALL 241
Query 244 ATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRD 303
A T GWLE+S VN S+ V+G+ +AVAA + G F++ ++V +P HTS L LR
Sbjct 242 ADTPGWLEVSAVNGPSSTVVAGDHEAVAAAAALAQQRGIFSQQLSVDYPGHTSALRPLRA 301
Query 304 ELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGAR 363
L P S F + PV+FIG T G + GT F YWY NL TVRFD AV+ A GA
Sbjct 302 ALAALTPKSVFRDGPVRFIGSTLGTELGDGTDFSAYWYENLCGTVRFDLAVQHARARGAD 361
Query 364 AFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGY 423
F+E+SAHP+LL+ +G + D V+VGS R D+LSA+IV+ A ADPG
Sbjct 362 TFVELSAHPSLLYPLGDIVD------DESIVIVGSGHRDRPITDSLSASIVAVAAADPGC 415
Query 424 PWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPE---PLPPVSGLTIAVERWERMV-PST 479
W D P+ L GFPNAPMRAV +WA PE P LT+AVE W+ P T
Sbjct 416 RWAD--ALPMADRAALRGFPNAPMRAVHLWAAPEQPNEPAPTPALTVAVEDWQPAAEPIT 473
Query 480 PVAGRHRHLAVLDLG--AHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV 537
P A + +D+G A Q L A+ + L + +AE+++VIAP+ + DA
Sbjct 474 PSA------SPVDVGFFGEGAPTQRLVDAVAAQDGCRLVSPSEAEVLVVIAPELDQLDAT 527
Query 538 RAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIG 597
A +A AGL DYP IG RC++V L+TVGAEQVD DA S QAALA MHRS+G
Sbjct 528 AAIEQIAGRPDAGLADYPALIGPRCRAVWLLTVGAEQVDGHDASVSPAQAALAGMHRSVG 587
Query 598 FEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLAD-APAV 656
FE P+Q F HLDL D+D +V+ +L E ALRG+ + A PA
Sbjct 588 FEFPDQAFGHLDLARRDVDAATAQAVVEVLLGEPAEVALRGNESPRRHLRTFRASRVPAT 647
Query 657 PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGT 716
P LD+ + DVV+TGG+GAIG+ YARY E GAR + LLSR D + L ++
Sbjct 648 PR-PLDAAAMADVVITGGSGAIGLQYARYCLERGARAVTLLSRNGVDPTVLRQLADRYRA 706
Query 717 VIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLG 776
+ +P CDITD L+A+AAE+ GASL++H AG + + +T + V AAKV G
Sbjct 707 EVRAPQCDITDRAALAAVAAEHPA-GASLLIHTAGIAQARSRAELTGSDVAAVCAAKVRG 765
Query 777 LAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKW 836
LA + ++WPLRPD R L CSSV GVWGG+ AY+A+NR+LDV+AAQLRA GR C A++W
Sbjct 766 LAMLADVWPLRPDCRILACSSVFGVWGGYTHAAYAASNRMLDVLAAQLRATGRDCTAIRW 825
Query 837 GLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQ 896
GLW G+ I R ERSGL M PQ+AIEASL+ + DPL+F AD RLQ
Sbjct 826 GLWHGA-------GVVVGNEITRTERSGLVAMEPQRAIEASLYRYEGDPLIFDADFERLQ 878
Query 897 MLLDSRQF-------------ERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESL 943
+ +S+ +R P + D VR +LAA L + + ++ L
Sbjct 879 VFFESQGMPMPFAVTRADDAGDREGAAAKP---LADIVRAELAATLHLGDSPAIDPGTPL 935
Query 944 FDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKL 986
DLGVDS+LALDLR RL+R++G +V ++ ++G IT L+ L
Sbjct 936 IDLGVDSLLALDLRKRLRRTVGNSVPVSRMLGGITMAELIDAL 978
>gi|254774737|ref|ZP_05216253.1| MbtD protein [Mycobacterium avium subsp. avium ATCC 25291]
Length=1015
Score = 731 bits (1886), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 478/1015 (48%), Positives = 607/1015 (60%), Gaps = 64/1015 (6%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTE-VARQLRKTRRVRRHR 59
M LPDGR+ VLLS+H ELI DA AI DYL R + T +A L + RR RRHR
Sbjct 1 MLSHHLPDGRIPVLLSSHDPELIRRDAAAILDYLGRIDSPNATAAIASTLLRLRRPRRHR 60
Query 60 AVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL 119
AVLRAAD ELA GL A+A G EH L+ S+ + PR AFVFPGQG W MGA AYREL
Sbjct 61 AVLRAADAAELAAGLAAIARGEEHELVTHSAKTTPPRIAFVFPGQGNQWQAMGAGAYREL 120
Query 120 PTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRS 179
P YR A D CA F AG SPLPYL+ +E +++ EI+GAQF HAV+LAE WR
Sbjct 121 PAYREAADRCAEEFVVAGFASPLPYLVG----EEERSWSRPEIQGAQFTHAVSLAEAWRC 176
Query 180 CGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDA 239
CGVLPD+T+GHSLGEVAAAY+A +I+L DAVA+V ARA VVGRL GRYA+A LG G A
Sbjct 177 CGVLPDITIGHSLGEVAAAYVAEAISLPDAVALVVARATVVGRLTGRYAMAVLGAGLDAA 236
Query 240 SALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLE 299
+L+A GW+E+S VN S+ V+G+ AVAA V + F ++V +P HTS L
Sbjct 237 ESLLAEAPGWVEVSAVNGPSSTVVAGDHDAVAAAVRLAQQRDVFTHQLSVDYPGHTSALR 296
Query 300 SLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIR 359
LR L E P S F + PV+F+G T G + GT F DYWY NL TVRFD AV+ A
Sbjct 297 PLRASLAELTPRSAFRDGPVRFVGSTRGAELGEGTDFSDYWYENLCGTVRFDLAVQYARA 356
Query 360 CGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVA 419
CGA F+E+SAHP+LL+ +G ++ +V+VGS R ++LSA+I + A A
Sbjct 357 CGADTFVELSAHPSLLYPLG-------DIVGDESVVVGSGHRERPVTESLSASIAAVAAA 409
Query 420 DPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPL-----PPVSGLTIAVERWER 474
DPG W D P L GFPNAPMRAV +WA PE + PP T+AVE W+
Sbjct 410 DPGCRWAD--AVPNADQPPLRGFPNAPMRAVHLWAAPERVTEAASPPAP--TVAVEDWQH 465
Query 475 MVPSTPVAGRHRHLAVLDLG--AHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFE 532
T VA R D+G ALA++L A+ + D + A AE++ ++AP +
Sbjct 466 ATLHT-VATRP------DIGFFGTDALARSLADAVAAQGDCRVVAPNQAEVLAIVAPRLD 518
Query 533 HTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAM 592
DA A +A AGL DYP IG RC++V L+TVGAEQVD D S QAALAAM
Sbjct 519 EHDATAAIEQIAARPDAGLPDYPALIGPRCRAVWLLTVGAEQVDRDDTHVSPAQAALAAM 578
Query 593 HRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGS----------VNG 642
HRS+GFE P+Q F HLDL D+D +V + E ALRG V
Sbjct 579 HRSVGFEFPDQAFGHLDLERADVDAATARAVADVLSGEAAEVALRGGEPPLSHVRSHVRS 638
Query 643 YTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAA 702
+ T P LD+ LDDVV+TGG+GAIG+ YARY E GAR + LLSR
Sbjct 639 FRECRETATSRP------LDAAALDDVVITGGSGAIGLQYARYCLERGARTVTLLSRTGV 692
Query 703 DQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVT 762
D A + L HG + +P CDITD L+++AA + G GASL++H AG + + +T
Sbjct 693 DPAALRELADGHGAEVRAPQCDITDRAALASVAATHAGSGASLLIHTAGIAQARSRADLT 752
Query 763 SAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAA 822
V AKV GLA M E+WPLRPD R L CSSV G WGG+G AY+A+NR+LDV+AA
Sbjct 753 GVDVAAVCDAKVRGLALMAEVWPLRPDCRILACSSVFGTWGGYGHAAYAASNRMLDVLAA 812
Query 823 QLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFT 882
QLRA GR C A++WGLWQ G+ I R ERSGL M P+ AIEASLH +
Sbjct 813 QLRADGRDCTAIRWGLWQGA-------GVVVGNEITRTERSGLVAMEPEAAIEASLHRYD 865
Query 883 VDPLVFAADAARLQMLLDSRQF-------ERYEGPTDPNLTI----VDAVRTQLAAVLGI 931
DPL+F AD RLQ+ +S+ +G ++ + + VR +LAA L +
Sbjct 866 GDPLIFDADFDRLQVFFESQGMPMPFSASHSGDGGAQEDVAVAKPLAEVVRAELAATLHL 925
Query 932 PQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKL 986
+ ++ SL DLGVDS+LALDLR RL+R++G +V +A ++G IT + L+ L
Sbjct 926 GDSLSIDPGTSLIDLGVDSLLALDLRKRLRRTVGNSVPVARMLGGITVNELIDAL 980
>gi|41408272|ref|NP_961108.1| MbtD [Mycobacterium avium subsp. paratuberculosis K-10]
gi|41396627|gb|AAS04491.1| MbtD [Mycobacterium avium subsp. paratuberculosis K-10]
Length=1013
Score = 729 bits (1883), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 472/1004 (48%), Positives = 608/1004 (61%), Gaps = 44/1004 (4%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATT--VTEVARQLRKTRRVRRH 58
M LPDGR+ VLLS+H ELI DA AI +YL+R +T VA L + RRVRRH
Sbjct 2 MPTHGLPDGRIPVLLSSHDPELIRRDAAAILEYLDRIGESTEATGAVAATLLRLRRVRRH 61
Query 59 RAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRE 118
RA+LRAADR ELA GL A+A G EH LI RS+ + PR AFVFPGQG W MGA AYR
Sbjct 62 RALLRAADRAELAAGLGAIARGEEHALITRSARTTPPRIAFVFPGQGNQWQAMGADAYRL 121
Query 119 LPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWR 178
LP YR A D CA AF +AG SPLPYL++P + Q++ EI+GAQF HAVALAE WR
Sbjct 122 LPAYREAADRCAQAFVSAGFPSPLPYLVSP----DEQSWTRPEIQGAQFTHAVALAEAWR 177
Query 179 SCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQD 238
GVLP++T+GHSLGEVAAAY+A +I+L DAVA+V ARA VV RL GRYA+A LG G D
Sbjct 178 CFGVLPEITIGHSLGEVAAAYVAEAISLPDAVALVVARATVVDRLTGRYAMAVLGTGAAD 237
Query 239 ASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVL 298
A +L+ATT GW+E+S VN ++ V+G+ AVAA V R FA + V +P HTS L
Sbjct 238 AESLLATTPGWVEVSAVNGPASTVVAGDHDAVAAAVRLARQREIFAHQLFVDYPGHTSAL 297
Query 299 ESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAI 358
LR L E P S F ++P++FIG T G VA T + YWY NL TVRFD AV+ A
Sbjct 298 RPLRAALAELTPQSAFRDSPIRFIGSTRGAEVAATTDYASYWYENLCSTVRFDLAVQCAR 357
Query 359 RCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAV 418
CGA AF+E+SAHP+LL+ + + + D AV+VGS R ++LSA++ + A
Sbjct 358 SCGADAFVELSAHPSLLYPL------SGIIDDESAVIVGSGHRDRPITESLSASMAAVAT 411
Query 419 ADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLP---PVSGLTIAVERWERM 475
ADPGY W + P L GFPNAPMRA +WA P+ + P LT+AVE W
Sbjct 412 ADPGYRWSETV--PTPNQPALHGFPNAPMRATHLWAAPDRVTEAAPRPRLTVAVEDWRHT 469
Query 476 VPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTD 535
T A GAH L + L A + + A +AE++ ++AP+ + D
Sbjct 470 TSPTTPTAADLGFA----GAH-PLTRRLADAAAAQGGCRVVAPGEAEILAIVAPELDQLD 524
Query 536 AVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRS 595
AV A + AGL DY IG RC++V L+TV AE VD D QAALAAMHRS
Sbjct 525 AVAAVEQIGAREDAGLPDYRGLIGPRCRAVWLLTVRAEHVDGDDDQACVAQAALAAMHRS 584
Query 596 IGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPA 655
IGFE P+Q F HLDLP D+D ++I +L E ALRG + RT
Sbjct 585 IGFEFPDQAFGHLDLPHRDVDAATAHAIIEVLLAEPAEVALRGEQSPRRHV-RTFRAHNE 643
Query 656 VPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHG 715
+ LD L+ VV+TGG+GAIG+HYARY + G R + LLSR + A + L H
Sbjct 644 SADRPLDDAALEHVVITGGSGAIGLHYARYCLQRGTRNLTLLSRNGIEAAVLRELTGSHD 703
Query 716 TVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVL 775
+ +P CDITD ++ AA Y G GA+L++H AG + + +T A V AAKV
Sbjct 704 ARVSAPRCDITDRAAVTQAAARYAGSGATLLIHTAGIAQARSRTDLTGADVAAVCAAKVR 763
Query 776 GLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVK 835
GLA M ++WPLRPD R L CSSV GVWGG+ AY+A+NR+LDV+A QLRA+G C A++
Sbjct 764 GLALMADVWPLRPDCRILACSSVFGVWGGYHHAAYAASNRMLDVLATQLRARGLDCTAIR 823
Query 836 WGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARL 895
WGLWQ G+ IAR ERSGL M P++A++ASLH + DPL+F AD RL
Sbjct 824 WGLWQDA-------GVVAGSEIARTERSGLVAMDPRRALQASLHRYESDPLIFDADFERL 876
Query 896 QMLLDSRQFER--YEGPTDPN--------LTIVDAVRTQLAAVLGIPQAGEVNLQESLFD 945
Q+ +S+ + PT + + + VR +LAA L + + ++ SL D
Sbjct 877 QVFFESQGMPMPFSDTPTRDDEAAAAPAGKPLAELVRAELAATLHLGDSVSIDPSASLID 936
Query 946 LGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA 989
LGVDS+LALDLR RL+R++G +V +A ++G IT VA+L DA
Sbjct 937 LGVDSLLALDLRKRLRRTVGNSVPVARMLGGIT----VAELVDA 976
>gi|336458166|gb|EGO37149.1| acyltransferase family protein,phosphopantetheine-containing
protein [Mycobacterium avium subsp. paratuberculosis S397]
Length=1012
Score = 728 bits (1879), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 472/1004 (48%), Positives = 608/1004 (61%), Gaps = 44/1004 (4%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATT--VTEVARQLRKTRRVRRH 58
M LPDGR+ VLLS+H ELI DA AI +YL+R +T VA L + RRVRRH
Sbjct 1 MPTHGLPDGRIPVLLSSHDPELIRRDAAAILEYLDRIGESTEATGAVAATLLRLRRVRRH 60
Query 59 RAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRE 118
RA+LRAADR ELA GL A+A G EH LI RS+ + PR AFVFPGQG W MGA AYR
Sbjct 61 RALLRAADRAELAAGLGAIARGEEHALITRSARTTPPRIAFVFPGQGNQWQAMGADAYRL 120
Query 119 LPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWR 178
LP YR A D CA AF +AG SPLPYL++P + Q++ EI+GAQF HAVALAE WR
Sbjct 121 LPAYREAADRCAQAFVSAGFPSPLPYLVSP----DEQSWTRPEIQGAQFTHAVALAEAWR 176
Query 179 SCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQD 238
GVLP++T+GHSLGEVAAAY+A +I+L DAVA+V ARA VV RL GRYA+A LG G D
Sbjct 177 CFGVLPEITIGHSLGEVAAAYVAEAISLPDAVALVVARATVVDRLTGRYAMAVLGTGAAD 236
Query 239 ASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVL 298
A +L+ATT GW+E+S VN ++ V+G+ AVAA V R FA + V +P HTS L
Sbjct 237 AESLLATTPGWVEVSAVNGPASTVVAGDHDAVAAAVRLARQREIFAHQLFVDYPGHTSAL 296
Query 299 ESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAI 358
LR L E P S F ++P++FIG T G VA T + YWY NL TVR D AV+ A
Sbjct 297 RPLRAALAELTPQSAFRDSPIRFIGSTRGAEVAATTDYASYWYENLCSTVRLDLAVQCAR 356
Query 359 RCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAV 418
CGA AF+E+SAHP+LL+ + + + D AV+VGS R ++LSA++ + A
Sbjct 357 SCGADAFVELSAHPSLLYPL------SGIIDDESAVIVGSGHRDRPITESLSASMAAVAT 410
Query 419 ADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLP---PVSGLTIAVERWERM 475
ADPGY W + P L GFPNAPMRA +WA P+ + P LT+AVE W
Sbjct 411 ADPGYRWSETV--PTPNQPALHGFPNAPMRATHLWAAPDRVTEAAPRPRLTVAVEDWRHT 468
Query 476 VPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTD 535
T A GAH L + L A + + A +AE++ ++AP+ + D
Sbjct 469 TSPTTPTAADLGFA----GAH-PLTRRLADAAAAQGGCRVVAPGEAEILAIVAPELDQLD 523
Query 536 AVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRS 595
AV A + AGL DY IG RC++V L+TV AE VD D QAALAAMHRS
Sbjct 524 AVAAVEQIGAREDAGLPDYRGLIGPRCRAVWLLTVRAEHVDGDDDQACVAQAALAAMHRS 583
Query 596 IGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPA 655
IGFE P+Q F HLDLP D+D ++I +L E ALRG + RT
Sbjct 584 IGFEFPDQAFGHLDLPHRDVDAATAHAIIEVLLAEPAEVALRGEQSPRRHV-RTFRAHNE 642
Query 656 VPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHG 715
+ LD L+ VV+TGG+GAIG+HYARY + GAR + LLSR + A + L H
Sbjct 643 SADRPLDDAALEHVVITGGSGAIGLHYARYCLQRGARNLTLLSRNGIEAAVLRELTGSHD 702
Query 716 TVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVL 775
+ +P CDITD ++ AA Y G GA+L++H AG + + +T A V AAKV
Sbjct 703 ARVSAPRCDITDRAAVTQAAARYAGSGATLLIHTAGIAQARSRTDLTGADVAAVCAAKVR 762
Query 776 GLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVK 835
GLA M ++WPLRPD R L CSSV GVWGG+ AY+A+NR+LDV+A QLRA+G C A++
Sbjct 763 GLALMADVWPLRPDCRILACSSVFGVWGGYHHAAYAASNRMLDVLATQLRARGLDCTAIR 822
Query 836 WGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARL 895
WGLWQ G+ IAR ERSGL M P++A++ASLH + DPL+F AD RL
Sbjct 823 WGLWQDA-------GVVAGSEIARTERSGLVAMDPRRALQASLHRYESDPLIFDADFERL 875
Query 896 QMLLDSRQFER--YEGPTDPN--------LTIVDAVRTQLAAVLGIPQAGEVNLQESLFD 945
Q+ +S+ + PT + + + VR +LAA L + + ++ SL D
Sbjct 876 QVFFESQGMPMPFSDTPTRDDEAAAAPAGKPLAELVRAELAATLHLGDSVSIDPSASLID 935
Query 946 LGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA 989
LGVDS+LALDLR RL+R++G +V +A ++G IT VA+L DA
Sbjct 936 LGVDSLLALDLRKRLRRTVGNSVPVARMLGGIT----VAELVDA 975
>gi|315443742|ref|YP_004076621.1| acyltransferase family protein [Mycobacterium sp. Spyr1]
gi|315262045|gb|ADT98786.1| acyltransferase family protein [Mycobacterium sp. Spyr1]
Length=960
Score = 721 bits (1861), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 479/996 (49%), Positives = 617/996 (62%), Gaps = 47/996 (4%)
Query 6 LPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAA 65
LPDGR+ VLLSAHAEELIG DAR + +L+ P V VA L + RR RHRAV+RAA
Sbjct 2 LPDGRIPVLLSAHAEELIGEDARRLLGFLDSAP--EVDAVAATLLRVRRRNRHRAVVRAA 59
Query 66 DRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTA 125
DR ELA+ L ALAAG+EHPL++RS+ A R+AFV+PGQG WP MGA AYR L YR A
Sbjct 60 DRSELADALSALAAGQEHPLVSRSAEPDAHRRAFVYPGQGNQWPAMGAEAYRTLRDYRQA 119
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
D CAAAF AAG SPL YL Q +E + AQF HAVAL VWR+ GV PD
Sbjct 120 ADVCAAAFTAAGAPSPLRYLTDAAAVTGSQ----VEAQAAQFTHAVALTAVWRAHGVAPD 175
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
+TVGHSLGEVAAA++AG+ITL++A AVV ARA V+ L Y +A LG+ +DA +LI +
Sbjct 176 MTVGHSLGEVAAAHVAGAITLAEAAAVVIARATVLEGLADGYGMAVLGLTPEDAQSLIES 235
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
GWLEL+VVNA+S+V VSGER AV A++ S G FAR +T+ FP HTS+L+ LR +
Sbjct 236 VPGWLELAVVNAASSVGVSGERDAVDALLAQASSRGVFARSVTMAFPAHTSLLDGLRADF 295
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
LP + F + + F+G TG+ V P T F DYW+ANLR+TVRFDRA +A+R GA F
Sbjct 296 VRLLPPARFQQTAIPFLGSATGEAVPPETDFADYWFANLRNTVRFDRAAAAAVRAGANLF 355
Query 366 IEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPW 425
+E+SAHPALLF++GQ+ G A+ VGS RR V L+A I + A D +PW
Sbjct 356 VEMSAHPALLFSLGQSA--------GDALTVGSGRRDAPLVKTLAAGIATVAAHDAEFPW 407
Query 426 GDLGGDPLDGDVD-----LSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
D+ +D L GFPNAPMR+V +WA P+PLP LT+A E WE P+
Sbjct 408 HDV--------IDTTRPALRGFPNAPMRSVHLWALPQPLPAPPSLTLATEAWEPHRPAER 459
Query 481 VAGRHRHLAVLDLGAHR-ALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRA 539
R AVLD+ R L L A+D HP + DA+L+L +AP+ D +
Sbjct 460 GLAL-RRTAVLDIAGPRGGLGDLLRDAVDHHPGMVSTPVHDADLVLAVAPNLGDPDVRES 518
Query 540 AGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFE 599
AL L+ GLL YP +G C+ + LVT AEQ+ D P QAALAAMHRSIGFE
Sbjct 519 VAALTALIDDGLLRYPDDVGTDCRDLWLVTTAAEQL-TGDPTPRPAQAALAAMHRSIGFE 577
Query 600 HPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVP-N 658
+P++ F HLDLP LD + + AVL G + ALR +F RT + P +
Sbjct 578 YPDRAFRHLDLPPVVLDEAAASAALDAVLGGGDDLALRDIDGMPAVFARTEHETVTTPES 637
Query 659 WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVI 718
W+ D G LD VV+TGG+G +G HYAR+LAE GARRI LLSR A + G +
Sbjct 638 WADDPGALDHVVITGGSGTVGQHYARHLAERGARRITLLSRHGAKGSAAG------GPGV 691
Query 719 VSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLA 778
+ CD+TDP L+ AAE+GG GA+L++HAAG+ +++AA D AAKV GL
Sbjct 692 QTVCCDVTDPVALAVAAAEFGGDGATLVIHAAGTAQFAEHDTLSAAAFADTAAAKVEGLF 751
Query 779 QMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGL 838
++ E WP RP R LLCSSV G+WGG G AY+AANRL+DV AAQ+RA+G C AV++GL
Sbjct 752 RIAEAWPRRPGARMLLCSSVSGLWGGRGHAAYAAANRLVDVTAAQMRAEGIRCAAVRFGL 811
Query 839 WQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQML 898
+ GI D ++ + RSGL + P A+ ASL + DP+V++AD ARLQ+
Sbjct 812 F--------GTGIVDEESVNLIGRSGLVPLDPDDAVAASLRDLPGDPIVYSADRARLQIF 863
Query 899 LDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRN 958
D P T V +L +VLGI AG V+L SL D+GVDS+LALDLR
Sbjct 864 RDDPAPPTATSPASGGDTTA-VVLAELTSVLGIEPAG-VDLDASLLDMGVDSLLALDLRK 921
Query 959 RLKRSIGATVSLATLMGDITGDGLVAKLEDADERSH 994
RL+R+ G +V LA ++G +TG L+ L+D +R+
Sbjct 922 RLRRATGRSVPLAPMLGGMTGAELITGLDDEPQRNE 957
>gi|118473284|ref|YP_888784.1| polyketide synthetase mbtd [Mycobacterium smegmatis str. MC2
155]
gi|118174571|gb|ABK75467.1| polyketide synthetase mbtd [Mycobacterium smegmatis str. MC2
155]
Length=997
Score = 721 bits (1861), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 506/1020 (50%), Positives = 637/1020 (63%), Gaps = 51/1020 (5%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
M L D RV V+LSAHAE+LI DA AI YL+ T ++VA L +TRR+RRHRA
Sbjct 2 MTDGTLCDHRVPVVLSAHAEDLIAHDATAILRYLDGRTDTAPSDVAYTLLRTRRLRRHRA 61
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSL---GSAPRQAFVFPGQGGHWPGMGAVAYR 117
V+RA EL GLRALA G +HPL+ R++ GS R AFVFPGQG WP MG AYR
Sbjct 62 VIRAGGLDELTAGLRALADGDDHPLVTRAAAPQPGSRRRVAFVFPGQGSQWPSMGVEAYR 121
Query 118 ELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTD-ERQAFCEIEIEGAQFVHAVALAEV 176
L YR D CAAAF AAG SPL YL+A P + F +++I+GAQFVH VALA V
Sbjct 122 -LDDYRAEVDRCAAAFEAAGAASPLDYLLAHPDSGVSTNDFSQVQIQGAQFVHGVALARV 180
Query 177 WRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGE 236
WRS GV+PD+TVGHSLGE+ AAY+AG+ITL +AVA+V ARA V+ RL G Y VA LGI
Sbjct 181 WRSHGVVPDITVGHSLGEIGAAYVAGAITLPEAVAIVIARATVLDRLTGPYRVAVLGITP 240
Query 237 QDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTS 296
+ A+ +IA T GWLELSVVN+ S+VAVSGE AVAA V TV + G FA+ I + FP HT+
Sbjct 241 EQAAEVIAETPGWLELSVVNSPSSVAVSGETGAVAAAVRTVAARGAFAKEIEMWFPAHTT 300
Query 297 VLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVES 356
L+ +R +L LP F E PVQFIG T DVV GT F DYWY NLR TVRFD+AV
Sbjct 301 ALDGVRADLDALLPAGRFAETPVQFIGSATADVVTTGTDFADYWYTNLRTTVRFDQAVAR 360
Query 357 AIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSA 416
A R GAR F+E+SAHPALLF +G+ E + VLVGS RR E + L+ N+++
Sbjct 361 AARRGARIFVELSAHPALLFNMGELLESTRGV-----VLVGSGRRDEPLPERLADNVITV 415
Query 417 AVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERM- 475
A+AD GY W D G D L FP APMRA +WA P+PLPPV+GLT+A E+W ++
Sbjct 416 ALADAGYRWRDQLG---DCHAVLPDFPFAPMRAEHLWAQPDPLPPVTGLTVAAEQWHQVA 472
Query 476 VPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTD 535
VP V+G HR +AV+ L + A+A L A + E+ A A+ +LV+AP D
Sbjct 473 VPE--VSGHHR-IAVVGLDSECAVAGHLRDAAERIEGVEVVAPAAADTLLVVAPMISEND 529
Query 536 AVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQ--VDAADAVPSAGQAALAAMH 593
V A L + GLL YP + + V LVT E VD ++P AA+AAMH
Sbjct 530 PVLAGEELGRRIDEGLLRYPDLLTETTRDVWLVTGRGEHVPVDRDGSLPVG--AAVAAMH 587
Query 594 RSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVN---GYTLFERTL 650
RSI FEHP+Q F LD+P LD V+ + A++ G + ALR V G TL+ R +
Sbjct 588 RSIAFEHPDQNFRQLDVPM-GLDTEAAVTAVAAMVTGTTDLALRCDVADGPGTTLWRRGM 646
Query 651 ADAPAVPN-WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAM 709
DA A W +GVLDDVV+TGG GA+G+ +AR LA GARRIVLLSR + V
Sbjct 647 RDASAAAAPWP--TGVLDDVVITGGTGAVGLQFARRLAALGARRIVLLSRNGIEGNRVDE 704
Query 710 LRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDN 769
L G IV+P CD+TD ++ +AAE+GG GASLIVHAA + +T AA
Sbjct 705 L--PLGVEIVAPRCDLTDIPRVRDVAAEFGGQGASLIVHAAATATIAAGSALTGAAAQAT 762
Query 770 FAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGR 829
F AK+ G+ ++ WP+RPD R LLCSSV G+WGGHG AY+AANRLLDVMA +LR++GR
Sbjct 763 FTAKLAGIENVLAAWPVRPDARILLCSSVSGLWGGHGHAAYAAANRLLDVMAERLRSEGR 822
Query 830 HCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFA 889
C AV+WGLW P GI DA I RVERSGLR MAP +A++ +L +F DPLVF+
Sbjct 823 RCTAVRWGLW-------PGAGIIDADEITRVERSGLRAMAPDRAVDTALQDFAGDPLVFS 875
Query 890 ADAARLQMLLDSR-------------QFERYEGPTD-PNLTIVDAVRTQLAAVLGIPQAG 935
ADA RL + L + Q P D + AVR LAAVL +
Sbjct 876 ADAQRLALFLGTDADTGTGREATHAAQHRDAGPPADAEHHDTGAAVRIALAAVLKLADTT 935
Query 936 EVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDADERSHT 995
++L SL DLGVDS+LALDLR +LK++ G +V LATL+G +T L+ LE ++ + +
Sbjct 936 GLDLDASLLDLGVDSLLALDLRKKLKKTTGRSVPLATLLGGVTATELIEHLERPEKETFS 995
>gi|145223282|ref|YP_001133960.1| acyl transferase region [Mycobacterium gilvum PYR-GCK]
gi|145215768|gb|ABP45172.1| acyl transferase region [Mycobacterium gilvum PYR-GCK]
Length=960
Score = 719 bits (1857), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 479/996 (49%), Positives = 617/996 (62%), Gaps = 47/996 (4%)
Query 6 LPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAA 65
LPDGR+ VLLSAHAEELIG DAR + +L+ P V VA L + RR RHRAV+RAA
Sbjct 2 LPDGRIPVLLSAHAEELIGEDARRLLGFLDSAP--EVDAVAATLLRVRRRNRHRAVVRAA 59
Query 66 DRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTA 125
DR ELA+ L ALAAG+EHPL++RS+ A R+AFV+PGQG WP MGA AYR L YR A
Sbjct 60 DRSELADALSALAAGQEHPLVSRSAEPDAHRRAFVYPGQGNQWPAMGAEAYRTLRDYRQA 119
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
D CAAAF AAG SPL YL Q +E + AQF HAVAL VWR+ GV PD
Sbjct 120 ADVCAAAFTAAGAPSPLRYLTDAAAVTGSQ----VEAQAAQFTHAVALTAVWRAHGVAPD 175
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
+TVGHSLGEVAAA++AG+ITL++A AVV ARA V+ L Y +A LG+ +DA +LI +
Sbjct 176 MTVGHSLGEVAAAHVAGAITLAEAAAVVIARATVLEGLADGYRMAVLGLTPEDAQSLIES 235
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
GWLEL+VVNA+S+V VSGER AV A++ S G FAR +T+ FP HTS+L+ LR +
Sbjct 236 VPGWLELAVVNAASSVGVSGERDAVDALLAQASSRGVFARSVTMAFPAHTSLLDGLRADF 295
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
L + F + + F+G TG+ V P T F DYW+ANLR+TVRFDRA +A+R GA F
Sbjct 296 VRLLAPARFQQTAIPFLGSATGEAVPPETDFADYWFANLRNTVRFDRAAAAAVRAGANLF 355
Query 366 IEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPW 425
+E+SAHPALLF++GQ+ G A+ VGS RR V+ LSA I + A D +PW
Sbjct 356 VEMSAHPALLFSLGQSA--------GDALTVGSGRRDAPLVETLSAGIATVAAHDAEFPW 407
Query 426 GDLGGDPLDGDVD-----LSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP 480
D+ +D L GFPNAPMR+V +WA P+PLP LT+A E WE P+
Sbjct 408 HDV--------IDTTRPALRGFPNAPMRSVHLWALPQPLPAPPSLTLATEAWEPHRPAER 459
Query 481 VAGRHRHLAVLDLGAHR-ALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRA 539
R AVLDL R L L A+D HP + DA+L+L +AP+ D +
Sbjct 460 GLAL-RRTAVLDLAGPRGGLGDLLRDAVDHHPGMVSTPVHDADLVLAVAPNLGDPDVRES 518
Query 540 AGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFE 599
AL L+ GLL YP +G C+ + LVT AEQ+ D P QAALAAMHRSIGFE
Sbjct 519 VAALTALIDDGLLRYPDDVGTDCRDLWLVTTAAEQL-TGDPTPRPAQAALAAMHRSIGFE 577
Query 600 HPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVP-N 658
+P++ F HLDLP LD + + AVL G + ALR +F RT + P +
Sbjct 578 YPDRAFRHLDLPPVVLDEAAASAALDAVLGGGDDLALRDIDGMPAVFARTEHETVTTPES 637
Query 659 WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVI 718
W+ D G LD VV+TGG+G +G HYAR+LAE GARRI LLSR A + G +
Sbjct 638 WADDPGALDHVVITGGSGTVGQHYARHLAERGARRITLLSRHGAKGSAAG------GPGV 691
Query 719 VSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLA 778
+ CD+TDP L+ AAE+GG GA+L++HAAG+ +++AA D AAKV GL
Sbjct 692 QTVCCDVTDPVALAVAAAEFGGDGATLVIHAAGTAQFAEHDTLSAAAFADTAAAKVEGLF 751
Query 779 QMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGL 838
++ E WP RP R L+CSSV G+WGG G AY+AANRL+DV AAQ+RA+G C AV++GL
Sbjct 752 RIAEAWPRRPGARMLVCSSVSGLWGGRGHAAYAAANRLVDVTAAQMRAEGIRCAAVRFGL 811
Query 839 WQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQML 898
+ GI D ++ + RSGL + P A+ ASL + DP+V++AD ARLQ+
Sbjct 812 F--------GTGIVDEESVNLIGRSGLVPLDPDDAVAASLRDLPGDPIVYSADRARLQIF 863
Query 899 LDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRN 958
D P T V +L +VLGI AG V+L SL D+GVDS+LALDLR
Sbjct 864 RDDPAPPTATSPASGGDTTA-VVLAELTSVLGIEPAG-VDLDASLLDMGVDSLLALDLRK 921
Query 959 RLKRSIGATVSLATLMGDITGDGLVAKLEDADERSH 994
RL+R+ G +V LA ++G +TG L+ L+D +R+
Sbjct 922 RLRRATGRSVPLAAMLGGMTGAELITGLDDEPQRNE 957
>gi|254819402|ref|ZP_05224403.1| MbtD protein [Mycobacterium intracellulare ATCC 13950]
Length=934
Score = 716 bits (1849), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 430/925 (47%), Positives = 559/925 (61%), Gaps = 47/925 (5%)
Query 82 EHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSP 141
EH L+ S+ + PR AFVFPGQG W MGA AYRELP YR A D CA F AG SP
Sbjct 2 EHELVTHSAKTTPPRIAFVFPGQGNQWQAMGAGAYRELPAYREAADRCAEEFVVAGFASP 61
Query 142 LPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLA 201
LPYL+ +E +++ EI+GAQF HAV+LAE WR CGVLPD+T+GHSLGEVAAAY+A
Sbjct 62 LPYLVG----EEERSWSRPEIQGAQFTHAVSLAEAWRCCGVLPDITIGHSLGEVAAAYVA 117
Query 202 GSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTV 261
+I+L DAVA+V ARA VVGRL GRYA+A LG G A +L+A GW+E+S VN S+
Sbjct 118 EAISLPDAVALVVARATVVGRLTGRYAMAVLGAGLDVAESLLAEAPGWVEVSAVNGPSST 177
Query 262 AVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQF 321
V+G+ AVAA V + F ++V +P HTS L LR L E P S F + PV+F
Sbjct 178 VVAGDHDAVAAAVRLAQQRDVFTHQLSVDYPGHTSALRPLRASLAELTPRSAFRDGPVRF 237
Query 322 IGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQN 381
+G T G + GT F DYWY NL TVRFD AV+ A CGA F+E+SAHP+LL+ +G
Sbjct 238 VGSTRGAELGEGTDFSDYWYENLCGTVRFDLAVQYARACGADTFVELSAHPSLLYPLG-- 295
Query 382 CEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSG 441
++ +V+VGS R ++LSA+I + A ADPG W D P L G
Sbjct 296 -----DIVGDESVVVGSGHRERPVTESLSASIAAVATADPGCRWAD--AVPNADQPPLRG 348
Query 442 FPNAPMRAVPMWAHPEPLPPV---SGLTIAVERWERMVPSTPVAGRHRHLAVLDLG--AH 496
FPNAPMRAV +WA PE + S T+AVE W+ T VA R D+G
Sbjct 349 FPNAPMRAVHLWAAPERVTEAASPSAPTVAVEDWQHATSHT-VATRP------DIGFFGT 401
Query 497 RALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPM 556
ALA++L A+ + D + A +AE++ ++AP + DA A +A AGL DYP
Sbjct 402 DALARSLADAVAAQGDCRVVAPNEAEVLAIVAPRLDEHDATAAIEQIAARPDAGLPDYPA 461
Query 557 HIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLD 616
IG RC++V L+TVGAEQVD D S QAALAAMHRS+GFE P+Q F HLDL D+D
Sbjct 462 LIGPRCRAVWLLTVGAEQVDRDDTNLSPAQAALAAMHRSVGFEFPDQAFGHLDLERADVD 521
Query 617 PVLGVSVITAVLRGFGETALRGS---VNGYTLFERTLADA-PAVPNWSLDSGVLDDVVVT 672
+V + E ALRG ++ RT + + + +LD+ LDDVV+T
Sbjct 522 AATARAVADVLSGDAAEVALRGGEPPLSHVRSHVRTFRECGESATSRALDAAALDDVVIT 581
Query 673 GGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVSPPCDITDPTQLS 732
GG+GAIG+ YARY E GAR + LLSR D A + L HG + +P CDITD L+
Sbjct 582 GGSGAIGLQYARYCLERGARTVTLLSRTGVDPAALRELADGHGAEVRAPQCDITDRAALA 641
Query 733 AIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRT 792
++AA + G GASL++H AG + + +T V AKV GLA M E+WPLRPD R
Sbjct 642 SVAATHAGSGASLLIHTAGIAQARSRADLTGVDVAAVCDAKVRGLALMAEVWPLRPDCRI 701
Query 793 LLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIA 852
L CSSV G WGG+G AY+A+NR+LDV+AAQLRA GR C A++WGLWQ G+
Sbjct 702 LACSSVFGTWGGYGHAAYAASNRMLDVLAAQLRADGRDCTAIRWGLWQGA-------GVV 754
Query 853 DAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQF-------E 905
I R ERSGL M P+ AIEASLH + DPL+F AD RLQ+ +S+
Sbjct 755 VGNEITRTERSGLVAMEPEAAIEASLHRYDGDPLIFDADFDRLQVFFESQGMPMPFSASH 814
Query 906 RYEGPTDPNLTI----VDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLK 961
+G ++ + + VR +LAA L + + ++ SL DLGVDS+LALDLR RL+
Sbjct 815 SGDGGAKEDVAVAKPLAEVVRAELAATLHLGDSLSIDPGTSLIDLGVDSLLALDLRKRLR 874
Query 962 RSIGATVSLATLMGDITGDGLVAKL 986
R++G +V +A ++G IT + L+ L
Sbjct 875 RTVGNSVPVARMLGGITVNELIDAL 899
>gi|296170583|ref|ZP_06852166.1| mycobactin biosynthesis enzyme MbtD [Mycobacterium parascrofulaceum
ATCC BAA-614]
gi|295894747|gb|EFG74473.1| mycobactin biosynthesis enzyme MbtD [Mycobacterium parascrofulaceum
ATCC BAA-614]
Length=957
Score = 687 bits (1774), Expect = 0.0, Method: Compositional matrix adjust.
Identities = 441/937 (48%), Positives = 563/937 (61%), Gaps = 39/937 (4%)
Query 66 DRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTA 125
DR ELA GL AL G EHPL+ RSSLG+AP AFVFPGQG W MGA AY+ LP YR
Sbjct 20 DRAELAAGLSALTRGEEHPLVHRSSLGAAPCIAFVFPGQGNQWQAMGAQAYQRLPAYRAE 79
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
+ CA F AG+ SPLPYL G +R + E++GAQF HAV+LA WR GVLP
Sbjct 80 AERCAREFRTAGLPSPLPYLT---GVRDRD-WSRTEVQGAQFTHAVSLAHEWRCHGVLPA 135
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
+TVGHSLGEVAAAY+AG+++L DAVA+V ARA ++ +L GRYA+A G +A +LIA
Sbjct 136 MTVGHSLGEVAAAYVAGTVSLPDAVALVGARAAIIDQLSGRYAMAVFGADMGEAESLIAE 195
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
T GWLE+S VN S+ VSG+ +AVAA V R G F ++V +P HTSVL LR L
Sbjct 196 TAGWLEVSAVNGPSSTVVSGDHEAVAAAVRLARQRGMFTHQLSVDYPGHTSVLRQLRARL 255
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
E +P+S F ++PV+F+G T G V P F DYWY NL +TVRFDRAVESA + GA AF
Sbjct 256 VELIPESAFRDSPVRFVGSTFGAQVGPDADFADYWYENLCNTVRFDRAVESARKLGASAF 315
Query 366 IEISAHPALLFAIGQNCEGAANLPDG-PAVLVGSARRGERFVDALSANIVSAAVADPGYP 424
+E+SAHP+LL+ + A+L D V+VGS R + L+ANI + A ADPG
Sbjct 316 VEMSAHPSLLYPL-------ADLVDERTTVVVGSGHRDGAVTEVLAANIAAVAAADPGCR 368
Query 425 WGDLGGDPLDGDVDLSGFPNAPMRAVPMW---AHPEPLPPVSGLTIAVERWERMVPSTPV 481
W + P L GFPNAPMR V +W P PP LT AVE W + +PS
Sbjct 369 WAN--AIPGGARPPLRGFPNAPMRTVHLWAAPEPPIEAPPGPALTAAVEHWRQAIPSE-A 425
Query 482 AGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAG 541
G + +D A L L A+++ D L + DAE++ ++AP + DA A
Sbjct 426 TGADIGIVAID-PADGPLPHRLTEAVEARRDCRLVSPHDAEILAIVAPALDTADATAAID 484
Query 542 ALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHP 601
LA AGL DY IG RC++V L+T AE V DA QAALAAMHRS+GFE
Sbjct 485 QLAARPDAGLPDYAALIGPRCRAVWLLTARAETVGPGDADAWPAQAALAAMHRSVGFEFA 544
Query 602 EQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVN--GYTLFERTLADAPAVPNW 659
+Q F HLDL D D +V+ A+L GE ALRG Y R D A P
Sbjct 545 DQAFGHLDLAGRDADARTASAVVDALLGEPGEVALRGGATPRAYVRTFRDCRDTAAGP-- 602
Query 660 SLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIV 719
LD+ L+ VV+TGG+GAIG+ YARY E GAR + LLSR + + L + HG +
Sbjct 603 PLDAAALEHVVITGGSGAIGLQYARYCIERGARTVTLLSRNGIGRDALRRLTENHGADVH 662
Query 720 SPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQ 779
+P CDITDP + A+AA + G GASL++H AG + + +T V AAKV GLA
Sbjct 663 APRCDITDPAAVRAVAARHAGTGASLLIHTAGIAEAHSRSDLTGEGVAAVCAAKVRGLAL 722
Query 780 MIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLW 839
+ WPLRPD R L CSSV GVWGGHG AY+A+NR+LDV+AAQLR GR C A++WGLW
Sbjct 723 LAGSWPLRPDCRILACSSVFGVWGGHGHAAYAASNRMLDVLAAQLRGTGRDCTAIRWGLW 782
Query 840 QAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLL 899
QA G+ A IAR ERSGL M P +AIEA L+ + DPL+F AD RL +
Sbjct 783 QAA-------GVVAADEIARTERSGLIAMVPARAIEAGLYRYDGDPLIFDADPDRLGVFF 835
Query 900 DSRQF-------ERYEGPTD--PNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDS 950
+S+ +G D P + + VR +LAA L + + ++ L DLGVDS
Sbjct 836 ESQGMAMPFDVPRGDDGGADGRPAKPLAEVVRDELAATLHLGDSLSIDTSAPLIDLGVDS 895
Query 951 MLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLE 987
+LALDLR RL+R++G++V +A ++G IT D L+ L
Sbjct 896 LLALDLRKRLRRTVGSSVPVARMLGGITLDELIDALR 932
>gi|333990181|ref|YP_004522795.1| polyketide synthase MbtD [Mycobacterium sp. JDM601]
gi|333486149|gb|AEF35541.1| polyketide synthase MbtD [Mycobacterium sp. JDM601]
Length=976
Score = 583 bits (1504), Expect = 4e-164, Method: Compositional matrix adjust.
Identities = 424/1004 (43%), Positives = 561/1004 (56%), Gaps = 70/1004 (6%)
Query 3 PKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
P LPDGR VL+SAHA +L+ +A A+A YL PA V VA+ LR TR +RR+R V+
Sbjct 6 PATLPDGRTPVLISAHARDLVQAEAGALARYLRNRPAG-VGAVAQTLRATRPIRRYRTVI 64
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTY 122
RA D EL GL A+ EHPL+ARS A R AFVFPGQG WPGMGA + E+ Y
Sbjct 65 RARDTDELISGLEAVYHDVEHPLVARSHRQEAARIAFVFPGQGNQWPGMGADLF-EIAAY 123
Query 123 RTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGV 182
D C AF AG SPL YL G D+ + ++ AQF HA ALA WR GV
Sbjct 124 CAEADRCEHAFRRAGHASPLTYLR---GADDPD---PVVVQAAQFTHAAALAATWRHFGV 177
Query 183 LPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLP----GRYAVAALGIGEQD 238
LPD+TVGHSLGE+AAAY AG++ L A AVV ARA + L GR+ +A + + D
Sbjct 178 LPDITVGHSLGELAAAYTAGAVDLDAAAAVVIARAELTDLLADNAAGRFGMAMIALAADD 237
Query 239 ASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVL 298
A+ LIA GWLELSV+N +V VSGE AV I++ G FAR + V +P HTSVL
Sbjct 238 AAELIAGISGWLELSVINGPESVVVSGEWAAVQQILERADRRGVFARELAVRYPAHTSVL 297
Query 299 ESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAI 358
E LRD + +LPD++F APV+FIG G + PG TF YW+ NLR VRFD A +A+
Sbjct 298 EPLRDRMTARLPDAQFHGAPVEFIGSVYGGPIPPGKTFRQYWFDNLRQQVRFDLAAAAAV 357
Query 359 RCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAV 418
G FIE+SAHP LL +G G A ++ S R + +AL+ANI +AA+
Sbjct 358 ARGVTNFIEMSAHPTLLVPLGDVA--------GTAQVLASTDRDQPAGEALAANIAAAAI 409
Query 419 ADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAV-ERWERM-V 476
DPGY W D L FP+APM +WA + P L + + E+W+ + V
Sbjct 410 TDPGYRWRDFAA---PAAAPLRHFPHAPMHTTRLWAGRKTPAPRHRLPVVMSEQWQSIEV 466
Query 477 PSTPVAGRHRHLAVLDL-GAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTD 535
P AG +AV+D G LA L AA+ + P + A +L+LV P D
Sbjct 467 PEDRPAG----MAVIDYTGQSPELAAELIAAMGADP---VDPAHAEQLVLVAPP----AD 515
Query 536 AVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRS 595
+ G + P +G C+ V L+T GAEQ+D D P AALAA+HRS
Sbjct 516 DIEITAVATAFTGPAVAQAPPALGVHCRRVWLITAGAEQLD-GDLPPRPQAAALAALHRS 574
Query 596 IGFEHPEQTFSHLDLPSWDLDPV---LGVSVITAVLRGFGETALRGSVNGYTLFERTLAD 652
GF HP+QTF+HLDLP +DP +G +V L E A+R R+ A
Sbjct 575 TGFAHPDQTFAHLDLP---VDPTADDIGAAVAALSLTD-TEVAVRAGRLSVRRLVRSDA- 629
Query 653 APAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQAT---VAM 709
APAVP + ++VV++GG GAIGM +A + A+HGAR I LLSR AT +A
Sbjct 630 APAVP------AIPENVVISGGTGAIGMAFAAFCADHGARDISLLSRSGDTDATADRLAA 683
Query 710 LRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDN 769
LR + G I + CDITD L+A+ AE+ A L+VH A S + A +T AAV D
Sbjct 684 LRMRTGARITAIRCDITDDAALAALIAEHHPAPAGLVVHTA-SAEAVAAEQITEAAVRDA 742
Query 770 FAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGR 829
AKV+GL ++ WP R D + L+CSSV+ +WGG G Y+AANR+ D + ++LRAQGR
Sbjct 743 LGAKVIGLDNLVRHWPQRADAQVLVCSSVLALWGGSGHGLYAAANRMADTLVSRLRAQGR 802
Query 830 HCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFA 889
+++WGLWQ + + R+ R+GL MAP+ AI L DP + A
Sbjct 803 SANSIRWGLWQ-------SVAVVSGEEKNRIARTGLTPMAPEAAITTGLSATPNDPAILA 855
Query 890 ADAARLQMLLDSR----QFERYEGPTDP---NLTIVDAVRTQLAAVLGIPQAGEVNLQES 942
AD RL + DS+ F+ P + + D V +LAAVLG+ + ++++ +
Sbjct 856 ADFDRLGVFFDSQGVPSPFDVTAAPASAISGDRPVGDVVVGELAAVLGLDRTDDIDMHRA 915
Query 943 LFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKL 986
L DLG+DS+LALDLR RL R+ G V+L L+ +T L A L
Sbjct 916 LVDLGMDSLLALDLRKRLARTTGRRVALGPLLAGMTAAQLTATL 959
>gi|289746159|ref|ZP_06505537.1| polyketide synthetase mbtD [Mycobacterium tuberculosis 02_1987]
gi|289686687|gb|EFD54175.1| polyketide synthetase mbtD [Mycobacterium tuberculosis 02_1987]
Length=235
Score = 436 bits (1122), Expect = 8e-120, Method: Compositional matrix adjust.
Identities = 222/223 (99%), Positives = 222/223 (99%), Gaps = 0/223 (0%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA
Sbjct 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP
Sbjct 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC
Sbjct 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRL 223
GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVG L
Sbjct 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGPL 223
>gi|54022732|ref|YP_116974.1| putative polyketide synthase [Nocardia farcinica IFM 10152]
gi|54014240|dbj|BAD55610.1| putative polyketide synthase [Nocardia farcinica IFM 10152]
Length=1028
Score = 427 bits (1099), Expect = 3e-117, Method: Compositional matrix adjust.
Identities = 352/1054 (34%), Positives = 502/1054 (48%), Gaps = 99/1054 (9%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
M+ LPDG V VL+S+ + + +A A+ YL+ P + VA L +TR RR+RA
Sbjct 1 MSSYLLPDGTVPVLISSDTADGVRAEAAAVLAYLDEHPRVSPERVAEMLFRTRVARRYRA 60
Query 61 VLRAADRLELAEGLRALAAGR-EHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL 119
+ R EL +GLRA+ A ++ SA R FVFPGQG PGMG + Y
Sbjct 61 LAMVRTREELLDGLRAVVADTPSRVVVTGDGAASARRIGFVFPGQGSQRPGMGRLYYDVS 120
Query 120 PTYRTATDTCAAAFAAAGV-DSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWR 178
YR A D CAA D PL YL+ G + R E++ A H LA +WR
Sbjct 121 DAYRAAVDACAAIHRERFEHDQPLHYLL---GDEGRYQDTVWEVQPALMFHMYGLAAMWR 177
Query 179 SCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGR-YAVAALGIGEQ 237
+ GV P TVGHS GE+AA ++ +TL D+V V RA +V R+ R Y++A LG+ +
Sbjct 178 AAGVEPAATVGHSQGELAAGAVSAVMTLRDSVLAVTHRARLVERISPRGYSMAVLGMDRE 237
Query 238 DASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSV 297
+ AL+A GW ELSVVNA +A+SG+R + +V+ + G FAR I V +P HTS+
Sbjct 238 ECEALLARHSGWAELSVVNAPHILAISGDRDTIVDMVELATARGQFAREIKVSYPAHTSI 297
Query 298 LESLRDELCEQLPDSE----FMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRA 353
+ LR+ L D F + + G T G + P T DYWY NLR+ VRFDRA
Sbjct 298 VAELREHFMSFLGDEMSGECFTASEIPCYGATLGAAITPDLTHRDYWYWNLRNRVRFDRA 357
Query 354 VESAIRCGARAFIEISAHPALLFAIGQNCE--GAANLPDGPAVLV-GSARRGERFVDALS 410
V +A+ G IE++ HP L A+ +N LP G V V G++ R + +
Sbjct 358 VVAAVTDGVDTLIEVAEHPVLQLALQENLTLVPREKLPLGRDVKVLGTSLRTAEGLAEFT 417
Query 411 ANIVSAAVADPGYPWGDLGGDPLDGDVD---LSGFPNAPMRAVPMWAHPEPLPPVSGLTI 467
N+ + AV D Y W L D DG L FP+ M +WA P+ LP
Sbjct 418 RNLATIAVHDLDYRWDALRTD--DGAAPRPPLRDFPHTIMHPRRLWAGPD-LPAAEPQPD 474
Query 468 AVERWERMVPS-TPVAGRH----RHLAVLD---------------LGAHRALAQTLCAAI 507
A ER+V + P+ R R LAV+D H A A L AA
Sbjct 475 AAPAPERLVETWIPLDKRSMLAPRTLAVVDHTGRCAELADALVAAADRHGATATVLDAAA 534
Query 508 DSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADLVGAGL----LDYPMHIGARCQ 563
+ E A +V+ P+ TD A A LD + G +C
Sbjct 535 LAGDLPEFDTA------VVLLPELPDTDGAAALDDFAAFFADRTWVPALDR-LGPGGQC- 586
Query 564 SVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSV 623
LVT G E V A D VP A+AA +RS G E P HLDL + P +
Sbjct 587 --WLVTTGGESVLADDPVPHLFHGAVAAGYRSAGIERPGILLRHLDLAA-GAGPDQAARI 643
Query 624 ITAV-LRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHY 682
+TAV G E ALRG L+ + L PA + D+ L V++ GG G +G+ +
Sbjct 644 VTAVHTAGECELALRGG----KLYVKRLVVDPATDASAADTD-LSHVLIVGGTGQLGLRF 698
Query 683 ARYLAEHGARRIVLLSRRAADQ---ATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYG 739
+ A GA R+ L+SR + + LR+ GT IV CD++D + AA
Sbjct 699 CEHFAHAGAGRVTLVSRSGETERVAGELNRLRRLGGTEIVVEACDVSDAEAVKRFAATIE 758
Query 740 GVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVM 799
SL++HAA + + P +T+ V + +KVLGL ++++ P R LLCSS
Sbjct 759 SAPVSLLIHAAVNYVDAELPDITAEMVTEAAGSKVLGLGTVLDIVPFTEQQRILLCSSTA 818
Query 800 GVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIAR 859
G G + Y+ NR+LD++A +LRAQGR ++++WGLW G D AR
Sbjct 819 ATLSGRGQILYAVTNRMLDILARRLRAQGRDAISIEWGLWSVA-------GPLDEAGFAR 871
Query 860 VERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQFER------------- 906
V +G+ MAP+ AI A L D ++ +AD A L+ +LD+ F +
Sbjct 872 VADAGVHPMAPRDAITAGLAGPWGDAMIMSADWAFLREVLDT--FGQGSVLPEIATPAAA 929
Query 907 ------------YEGPTDP--NLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSML 952
E P P + + + + TQL V+G + ++ L LG+DS+
Sbjct 930 SAPEPDVAEPVVTEQPAAPAADRPLAERMLTQLHKVMGTDGSESIDGSVPLVALGLDSLQ 989
Query 953 ALDLRNRLKRSIGATVSLATLMGDITGDGLVAKL 986
ALD R R+K + + +A ++G + D +VA +
Sbjct 990 ALDFRKRVKAELDRDLPVAAILGGASLDDVVALM 1023
>gi|183983675|ref|YP_001851966.1| polyketide synthase MbtD [Mycobacterium marinum M]
gi|183177001|gb|ACC42111.1| polyketide synthase MbtD [Mycobacterium marinum M]
Length=1024
Score = 420 bits (1079), Expect = 9e-115, Method: Compositional matrix adjust.
Identities = 339/1047 (33%), Positives = 508/1047 (49%), Gaps = 91/1047 (8%)
Query 2 APKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAV 61
A +LPDG + VLLSA EL+ +A A+ D++ P T ++ L +TR RRHRA+
Sbjct 4 AAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAHPDLTPGPISAMLFRTRAARRHRAL 63
Query 62 LRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQ-AFVFPGQGGHWPGMGAVAYRELP 120
R EL + L+A+ EHP + R+ + R+ +VFPGQGG PGMG + Y +P
Sbjct 64 AMVRTRAELIDALQAMIDRYEHPALIRTDPAAIRRRIGYVFPGQGGQRPGMGQLFYESVP 123
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
+R D CA AF A SP YL+ D+ A ++ A F ALA +WRS
Sbjct 124 AFRAEVDRCAQAFEAQSCGSPRNYLLDKNFQDDGSAGI---VQPALFTQMAALAAMWRSF 180
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
G+ P++T+GHS GEVAAAY++G+ITL DAV V+ RA+ A+ +++
Sbjct 181 GIAPNVTIGHSQGEVAAAYVSGTITLEDAVRVIGIRAHAADEFAAADYAMAIVAADRETC 240
Query 241 A-LIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVL- 298
L+A GW +LSVVN+ V +SGER+ V IVDT+ G FAR I V +P HTS++
Sbjct 241 EDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTEGGTFARVIRVRYPAHTSLIH 300
Query 299 ---ESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVE 355
+ LR + +QL F++ + +G T G + GDYW+ NLR+ VRFD+A+
Sbjct 301 DGADKLRAAIQDQLQHPSFVDTDIDCLGATLGAPITSELPVGDYWFWNLRNIVRFDKAIA 360
Query 356 SAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDG-PAVLVGSARRGERFVDALSANIV 414
+A++ F+E++ HP L AI +N + D PA++VG++ R + + N+
Sbjct 361 AAVQRDVETFVELAEHPTLQLAIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLA 420
Query 415 SAAVADPGYPWGDLGGDPLDGD--VDLSGFPNAPMRAVPMW-----AHPEPLPPVSGLTI 467
AV D YPW L +P DG + L FPN M + +W P PP +
Sbjct 421 QLAVHDLNYPWECLRAEP-DGAQALPLLDFPNTRMNEIRLWLPYDEVLPRRQPPSVSVAP 479
Query 468 A-----------------VERWERMVPSTPVAGRHRHLAVLD-LGAHRALAQTLCAA--- 506
A VE W R+ S R + ++D GA LA + AA
Sbjct 480 AAPSVPDATADTTPARLLVEEWVRL--SQRSLTPPRVVGIVDPTGACAQLATAMTAAAHQ 537
Query 507 -------IDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIG 559
++ D D ++++ P+ D RAA A + +P +
Sbjct 538 AGATARVVNGEND---GTGADVNTLVILLPETPKLDG-RAAAAEVGGFFSNRAWWP-GVD 592
Query 560 ARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPS------W 613
LVTVG E AAD P AA +A RSIG EHP F HLDLP+ W
Sbjct 593 TGVTDCWLVTVGGEAATAADGPPDPVHAAASAGFRSIGAEHPGVGFRHLDLPAGATAQDW 652
Query 614 DLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTG 673
I A L E L +G +R +A AV + + + V++ G
Sbjct 653 -------AHPIVAALHTANEPEL-AYRDGAFYAKRIVAGEGAVVHGA--GACPEHVLIIG 702
Query 674 GAGAIGMHYARYLAEHGARRIVLLSRRAADQAT---VAMLRKQHGTVIVSPPCDITDPTQ 730
G G +G+ + + A GARRI L+SR A +A LR I CD+ DP
Sbjct 703 GTGNLGLEFCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTRCDVGDPAA 762
Query 731 LSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDV 790
+S +AA++ A LI+HAA + S +T+ + AKV+G+ Q+++ +P
Sbjct 763 VSRLAAQHRSTPADLIIHAAVAYASVEFSDITTDDADNALYAKVVGIGQVLDAFPRTDGC 822
Query 791 RTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARG 850
R +LCSS GG G V Y+AANR+LD MA +LRA+G CV+V+WG W
Sbjct 823 RIVLCSSARATIGGRGQVMYAAANRMLDAMAHRLRAEGLDCVSVQWGQWT-------VHF 875
Query 851 IADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQF------ 904
DA ++A++ G+ M P +AI + + +V A D R + +L++ +
Sbjct 876 DLDASSMAQLAAIGVIPMPPAEAIALGMQRLGRNAIVAAFDFDRARPVLETFGYGPLVSE 935
Query 905 -----ERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNR 959
P +P + + LAA +G +A ++ + LG+DS+ AL+LR R
Sbjct 936 LLSPVSETAAPAEPA-DLPGRLSNLLAAAIGAERAERIDTSVPMVALGLDSLQALELRRR 994
Query 960 LKRSIGATVSLATLMGDITGDGLVAKL 986
+K + ++ L+G + ++A+L
Sbjct 995 VKAEFDHELEVSDLLGGASIADVLAQL 1021
>gi|262200641|ref|YP_003271849.1| acyl transferase [Gordonia bronchialis DSM 43247]
gi|262083988|gb|ACY19956.1| Acyl transferase [Gordonia bronchialis DSM 43247]
Length=1560
Score = 411 bits (1057), Expect = 3e-112, Method: Compositional matrix adjust.
Identities = 358/1087 (33%), Positives = 520/1087 (48%), Gaps = 141/1087 (12%)
Query 1 MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA 60
MA +LPDG V++SA L+ + ++ADYL R P + +++R L ++R VRR RA
Sbjct 1 MATLRLPDGTSPVVVSADTPALLRAEGASLADYLTRAPHVSPDQLSRMLFRSRPVRRFRA 60
Query 61 VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQ--AFVFPGQGGHWPGMGAVAYRE 118
++ A D L EGLRA+A G +HP + RS G A R A VFPGQGG PGMGA+ +R
Sbjct 61 LVSARDAAALVEGLRAVATGTDHPAVVRSD-GPARRSRIALVFPGQGGQRPGMGALYHRH 119
Query 119 LPTYRTATDTCAAAFAAAGVDSPLPYLIAP-PGTDERQAFCEIEIEGAQFVHAVALAEVW 177
+ + A F SP YL+ P D I+ A F+ ALA +W
Sbjct 120 SAAFAAEVERLHAVFEEVAGCSPRSYLLDDDPDRDTSADDTAALIQPALFMQMAALAAMW 179
Query 178 RSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGR-YAVAALGIGE 236
RS GV+P++ VGHS GE+AA Y+AG + L DA+ V+ RA V + Y++A L
Sbjct 180 RSFGVVPEIVVGHSQGEIAACYVAGVMDLHDAITVLTTRARSVDTTASQQYSMAVLDTDR 239
Query 237 QDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTS 296
+A +L+A GW E+SV+N+ VSG+ + ++VD + +G F+R I V +P HT+
Sbjct 240 AEAESLLARRSGWAEISVINSPRMTGVSGDTPIITSVVDQLAEAGRFSRVIAVRYPAHTA 299
Query 297 VLE----SLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDR 352
V+ ++ D E+L D F P+ IG T G+ + P G+YW+ NLR+ VRFD+
Sbjct 300 VMHEVARTILDATGERLSDKGFTATPITCIGSTLGEEITPDLPLGEYWFWNLRNVVRFDK 359
Query 353 AVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSAN 412
AV A+ GA F+E+S HP L IG+ E A D A +VG++RR + ++ N
Sbjct 360 AVARAVALGANTFVELSEHPTLQLPIGETLESIA---DATATVVGTSRRQAEDMSVIARN 416
Query 413 IVSAAVADPGYPWGDL--GGDPLDGD--VDLSGFPNAPMRAVPMWA-----HPEPLPPVS 463
+V AV D + W L D G + L FP+ +W PE PP +
Sbjct 417 LVLIAVGDLDFDWTSLLVEDDTARGSAALPLPDFPHTITNDSFLWMTYATNRPEVSPPHA 476
Query 464 G--------------LTIAVERWERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDS 509
G +T+A +RW R+ + VA + + ++DLGA LA A ++
Sbjct 477 GTSAPATPAAVPDPTMTVA-QRWVRIPRRSMVA--PQTMGIVDLGALPGLAD---AIVEH 530
Query 510 HPDTELSAAR---------DAEL------ILVIAP--------DFEHTDAVRAAGALADL 546
PD +A R DA L ++V+ P D +A+ G AD
Sbjct 531 APDFGAAARRIDVAAESSDDATLLDGVDTVVVLGPAGAREPRADARTREAI---GQAADF 587
Query 547 VGA----GLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPE 602
G D P + LVTVG E V ++ P G A +AA R +G E+P
Sbjct 588 FGERRWWSAADPP-------RDHWLVTVGGEAVTDNES-PEIGAAGIAAGFRCLGAEYPN 639
Query 603 QTFSHLDL-----PSWDLDPVLGVSVITAV-LRGFGETALRGSVNGYTLFERTLADAPAV 656
+F HLDL + +D + ++ A+ + + ALRG LF + L PA
Sbjct 640 ASFGHLDLDPALLETGTVDAAVADKIVAALHIAREPDIALRGK----DLFVKRLT--PAD 693
Query 657 PNWSLDS-GVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD---QATVAMLRK 712
+ ++ V++TGG G +G+ +A + A G R+ L+SRR A Q + LR+
Sbjct 694 DTATAETPAAGRHVLITGGTGKVGLEFADHFAAQGVTRLTLVSRRGATPEVQRRLDALRR 753
Query 713 QHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTA----PGVTSAAVVD 768
+GT +V CDITD Q+ A+ + +HAA + GT +T V
Sbjct 754 -NGTEVVVQRCDITDDAQVRALGESLADAPVDVAIHAAADLPPGTGGIGLEDITGDVVSR 812
Query 769 NFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQG 828
AKV G+ +++ P DVR LLCSS GG G + YSAANR+LD +A LRA G
Sbjct 813 LCDAKVAGVHRILGAVPTSDDVRVLLCSSFAATIGGRGTIVYSAANRMLDAVATALRADG 872
Query 829 RHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVF 888
C +V+WG W A G ADA T+A V G R M + AI A L + +V
Sbjct 873 VDCASVQWGQW----AVHDGSGAADAATLAAV---GYRTMPSESAIRAGL-AVRHNAIVA 924
Query 889 AADAARLQMLLDSRQF-------------------------ERYEGPTDPNLTIVDAVRT 923
A D R +L R F + GP P V +RT
Sbjct 925 AFDWQRGHEVL--RDFGYGPLLSDLASAEPAPPRPSTRPAADSTPGPAAPQ--PVRDLRT 980
Query 924 Q----LAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITG 979
+A V+G ++ L LG+DS+ ALDLR ++ G + + L+G +
Sbjct 981 AALAVVADVIGAADVDAIDTTRPLVALGLDSLQALDLRRKVTEQFGYELPVTELVGGASL 1040
Query 980 DGLVAKL 986
D + A L
Sbjct 1041 DDVTALL 1047
>gi|118618910|ref|YP_907242.1| polyketide synthase MbtD [Mycobacterium ulcerans Agy99]
gi|118571020|gb|ABL05771.1| polyketide synthase MbtD [Mycobacterium ulcerans Agy99]
Length=1024
Score = 410 bits (1053), Expect = 8e-112, Method: Compositional matrix adjust.
Identities = 336/1047 (33%), Positives = 507/1047 (49%), Gaps = 91/1047 (8%)
Query 2 APKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAV 61
A +LPDG + VLLSA EL+ +A A+ D++ P T ++ L +TR RRHRA+
Sbjct 4 AAYRLPDGTIPVLLSADTPELLDSEATALRDHVAAHPDLTPGPISAMLFRTRAARRHRAL 63
Query 62 LRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQ-AFVFPGQGGHWPGMGAVAYRELP 120
R EL + L+A+ EHP + R+ + R+ +VFPGQGG PGMG + Y +P
Sbjct 64 AMVRTRAELIDALQAMIDRYEHPALIRTDPAAIRRRIGYVFPGQGGQRPGMGQLFYESVP 123
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC 180
+R D CA AF A SP YL+ D+ A ++ A F ALA +WRS
Sbjct 124 AFRAEVDRCAQAFEAQACGSPRNYLLDKNFQDDGSAGI---VQPALFTQMAALAAMWRSF 180
Query 181 GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS 240
+ P++T+GHS GEVAAAY++G+ITL DAV V+ RA+ A+ +++A
Sbjct 181 DIPPNVTIGHSQGEVAAAYVSGTITLEDAVRVIGIRAHAADEFAAADYAMAIVAADREAC 240
Query 241 A-LIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVL- 298
L+A GW +LSVVN+ V +SGER+ V IVDT+ G FAR I V +P HTS++
Sbjct 241 EDLLARCSGWAQLSVVNSPRMVGISGERETVQGIVDTLTEGGTFARVIRVRYPAHTSLIH 300
Query 299 ---ESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVE 355
+ LR + +QL F++ + +G T G + GDY + NLR+ VRFD+A+
Sbjct 301 DGADKLRAAIQDQLQHPSFVDTDIDCLGATLGAPITSELPVGDYCFWNLRNIVRFDKAIA 360
Query 356 SAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDG-PAVLVGSARRGERFVDALSANIV 414
+A++ F+E++ HP L AI +N + D PA++VG++ R + + N+
Sbjct 361 AAVQRDVETFVELAEHPTLQLAIHENLAALRDEADDRPAMVVGTSERTATDLGEFTRNLA 420
Query 415 SAAVADPGYPWGDLGGDPLDGD--VDLSGFPNAPMRAVPMW-----AHPEPLPPVSGLTI 467
AV D YPW L +P DG + + FPN M + +W P PP +
Sbjct 421 QLAVHDLNYPWECLRAEP-DGAQALPMLDFPNTRMNEIRLWLPYDEVLPRRQPPSVSVAP 479
Query 468 A-----------------VERWERMVPSTPVAGRHRHLAVLD-LGAHRALAQTLCAA--- 506
A VE W R+ S R + ++D GA LA + AA
Sbjct 480 AAPSVPDATADTTPARLLVEEWVRL--SQRSLTPPRVVGIVDPTGACAQLATAMTAAAHQ 537
Query 507 -------IDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIG 559
++ D D ++++ P+ D RAA A + +P +
Sbjct 538 AGATARVVNGEND---GTGADVNTLVILLPETPKLDG-RAAAAEVGGFFSNRAWWP-GVD 592
Query 560 ARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPS------W 613
LVTVG E AAD P AA +A RSIG EHP+ F HLDLP+ W
Sbjct 593 TGVTDCWLVTVGGEAATAADGPPDPVHAAASAGFRSIGAEHPDVGFRHLDLPAGATAQDW 652
Query 614 DLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTG 673
I A L E L +G +R +A AV + + + V++ G
Sbjct 653 -------AHPIVAALHTANEPEL-AYRDGAFYAKRIVAGEGAVVHGA--GACPEHVLIIG 702
Query 674 GAGAIGMHYARYLAEHGARRIVLLSRRAADQAT---VAMLRKQHGTVIVSPPCDITDPTQ 730
G G +G+ + A GARRI L+SR A +A LR I CD+ DP
Sbjct 703 GTGNLGLESCDHFAHRGARRITLVSRSGESAAVAERLAQLRSATAAQIAVTRCDVGDPAA 762
Query 731 LSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDV 790
+S +AA++ A LI+HAA + S +T+ + AKV+G+ Q+++ +P
Sbjct 763 VSRLAAQHRSTPADLIIHAAVAYASVEFSDITTDDADNALYAKVVGIGQVLDAFPRTDGC 822
Query 791 RTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARG 850
R +LCSS GG G V Y+AANR+LD MA +LRA+G CV+V+WG W
Sbjct 823 RIVLCSSARATIGGRGQVMYAAANRMLDAMAHRLRAEGLDCVSVQWGQWT-------VHF 875
Query 851 IADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQF------ 904
DA ++A++ G+ M P +AI + + +V A + R + +L++ +
Sbjct 876 DLDASSMAQLAAIGVIPMPPAEAIALGMQRLGRNAIVAAFNFDRARPVLETFGYGPLVSE 935
Query 905 -----ERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNR 959
P +P + + LAA +G +A ++ + LG+DS+ AL+LR R
Sbjct 936 LLSPVSETAAPAEPA-DLPGRLSNLLAAAIGAERAERIDTSVPMVALGLDSLQALELRRR 994
Query 960 LKRSIGATVSLATLMGDITGDGLVAKL 986
+K + ++ L+G + ++A+L
Sbjct 995 VKAEFDHELEVSDLLGGASIADVLAQL 1021
>gi|169629205|ref|YP_001702854.1| putative polyketide synthase MbtD [Mycobacterium abscessus ATCC
19977]
gi|169241172|emb|CAM62200.1| Putative polyketide synthase MbtD [Mycobacterium abscessus]
Length=1010
Score = 405 bits (1041), Expect = 2e-110, Method: Compositional matrix adjust.
Identities = 323/1025 (32%), Positives = 478/1025 (47%), Gaps = 88/1025 (8%)
Query 26 DARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPL 85
+A A+ Y+ P +A + +TR RR+RA+ + +L LR + AG EHPL
Sbjct 5 EASALLAYVADHPRIAPNRIAGMIFRTRVARRYRALATVENHDQLVAALRTVVAGTEHPL 64
Query 86 IARSSL-GSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPY 144
+ R+S +A R FVFPGQGG PGMG + Y P++R + CA F SPL Y
Sbjct 65 VVRNSEPATARRHGFVFPGQGGQRPGMGRLFYDAFPSFRAEVERCADLFDKQFGRSPLSY 124
Query 145 LIAP--PGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAG 202
L+ P D ++ A F V LA +WR+ GV P VGHS GE+A AY++G
Sbjct 125 LLDDQLPTNDSATV-----VQPALFTQMVGLAALWRTVGVTPRAVVGHSQGEIAGAYVSG 179
Query 203 SITLSDAVAVVAARANVVGRLPGR-YAVAALGIGEQDASALIATTGGWLELSVVNASSTV 261
++L DAV VV RA + P YA+A + L+A GW ELSV+N+ S V
Sbjct 180 VMSLDDAVTVVGTRAGIADEFPADDYAMAVIATDRDTCEELLARNSGWAELSVINSPSMV 239
Query 262 AVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESL----RDELCEQLPDSEFMEA 317
+SG+R+ V IV+ + G FAR I V +P HTS++ S+ R L E L EF +
Sbjct 240 GISGQRETVHQIVEHLIEDGVFARVIPVRYPAHTSMIASIGAQIRHALTENLDAGEFTVS 299
Query 318 PVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFA 377
+ IG T G ++P YW+ NLR+ VRFDRAV +A F+E++ HP L A
Sbjct 300 EIDCIGATLGTAISPEMPVDQYWFWNLRNAVRFDRAVATAAAAHVDTFVELAEHPTLQLA 359
Query 378 IGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWGDLGGDPLDG-D 436
+ +N AA + A +VG++ R + +AN+ AV D Y W L + D
Sbjct 360 LRENL--AALGSERTACVVGTSHRNATDLGEFTANLAKIAVHDLDYNWDALRTEAPDRVS 417
Query 437 VDLSGFPNAPMRAVPMWAHPE--------PLPPVSGLTIAVERWERMVPSTPVAGR---- 484
+ L FPN +P+W P P+ +T ER M + R
Sbjct 418 LPLRDFPNVQNNDIPLWLSYRADTSGVAVPKQPI--VTPEAERRVEMGNDSRAYPRLLRE 475
Query 485 ------------HRHLAVLD-LGAHRALAQTLCAAIDSHPD----------TELSAARDA 521
R A +D G AL + L DS P+ T+ S DA
Sbjct 476 AWAKVTRRSMMPPRSYAFIDGTGDAGALVEALR---DSAPNFGSSARIVTGTDESGIGDA 532
Query 522 ELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAV 581
+ ++++ P D AA A+A G +P + + LVTVG EQ A D
Sbjct 533 DTVVIVLPSPALLDDHEAADAVARFFGNRTW-WP-RLSSTVTGCWLVTVGGEQAIADDGP 590
Query 582 PSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVN 641
AA+AA R +G EHP F HLDL S D+ I A L+ GE+ L +
Sbjct 591 AHPVHAAIAAGFRCMGTEHPGIAFRHLDLTS-DIASPDKADNILAALQSAGESELALRAD 649
Query 642 GYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA 701
G ++ + + D + S VV+TGG G +G + + A G R+I L+SR
Sbjct 650 G--MYAKRVLDIDQDGDESSRVVAPAHVVITGGTGKLGQEFCEHYARMGTRQITLISRSG 707
Query 702 ADQATVAML---RKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTA 758
A L R+ G + + PCD+TD ++A+A + A LIVHAA
Sbjct 708 ETDAVTGRLDAIRRSTGAKVRALPCDVTDTAAVTALADQLRDTPADLIVHAAVDYSDTPL 767
Query 759 PGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLD 818
VT+ D AKV+G++ +++ P R +LCSS+ GG G + Y+A NR+LD
Sbjct 768 SEVTTNKFQDALRAKVIGISNVLDTVPRTDSCRVMLCSSLAATIGGKGQLMYAAGNRMLD 827
Query 819 VMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASL 878
V+A+ RA G C +++WG W + DA IA++ +G+ M P A+ +
Sbjct 828 VLASTRRASGLDCTSIQWGQWTV------HLDLGDA-GIAKLAAAGVHPMRPADALAVGM 880
Query 879 HEFTVDPLVFAADAARLQMLLDS-------RQFERYEGPTDPNLT-----IVDAVRTQ-- 924
+ LV A D + + +L + E GP P T +V R+
Sbjct 881 GHHHGNTLVGAFDLTQARAMLGVFGYGPLLSELEDNGGPVAPAETTRPAPVVSENRSGHL 940
Query 925 ---LAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDG 981
LA V+G A ++ + +G+DS+ AL+ R R++ + + + L+G + D
Sbjct 941 VQLLAEVIGADHADSIDTAMPMVAMGLDSLQALEFRRRVQAELDFELPVQDLLGGASVDH 1000
Query 982 LVAKL 986
++ L
Sbjct 1001 VIDAL 1005
>gi|326383358|ref|ZP_08205045.1| putative polyketide synthase [Gordonia neofelifaecis NRRL B-59395]
gi|326197764|gb|EGD54951.1| putative polyketide synthase [Gordonia neofelifaecis NRRL B-59395]
Length=1030
Score = 384 bits (985), Expect = 7e-104, Method: Compositional matrix adjust.
Identities = 357/1067 (34%), Positives = 500/1067 (47%), Gaps = 134/1067 (12%)
Query 6 LPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAA 65
LPDG V V++SA AE+ +G A ++A YL P V VA L R VRRHRAV A
Sbjct 14 LPDGLVPVVVSADAEDRLGRYAASVAGYLREHPDVDVDRVAAYLLDARPVRRHRAVAAVA 73
Query 66 DRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTA 125
DR L + L A+A GR HP + R S S R A+V+PGQG PGMGAV YR YRTA
Sbjct 74 DRDALLDALDAVADGRPHPDVVRGSAASH-RFAYVYPGQGSQRPGMGAVDYRCSAAYRTA 132
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCG 181
D C A SP+ Y++ R A E + ++ A F+H + L +W + G
Sbjct 133 VDDCHEASMELFGTSPIDYVLG------RDAAVETDDVTVVQPALFMHMLGLTAMWDAAG 186
Query 182 VLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRL-PGRYAVAALGIGEQDAS 240
V P +TVGHS GE+AAA +G +L +A+ VV RA V + P Y +A LG+ +A
Sbjct 187 VRPAMTVGHSQGEIAAAVRSGVASLREALVVVTMRARAVDAIAPRGYTMAVLGVSLDEAE 246
Query 241 ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES 300
AL+A GW+ELSVVN++ + VSGER AV ++ + + G FA+ I V +P HTS++
Sbjct 247 ALLARNSGWIELSVVNSAHILCVSGERPAVLGLIAALEADGKFAKEIRVAYPAHTSIVSK 306
Query 301 LRDELCEQLPD----SEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVES 356
E F + IG T G+ + T DYW+ NLR+ VRFDRAV +
Sbjct 307 FAAEFVTAFDSFGLGERFSTPRIPCIGATLGEAIDETMTLRDYWFWNLRNRVRFDRAVAT 366
Query 357 AIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSA 416
A GA FIEI+ HP L+ A+ + ++G+ RR + N+++
Sbjct 367 AATDGADTFIEIAEHPTLVLAMSETLAETTG-----TTILGTRRRECTDHSLFTKNVLAV 421
Query 417 AVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAH-------PEPLP------PVS 463
AVAD + W + L GFPN+ MR +WA P P P
Sbjct 422 AVADSAFDWSRWAVPGRTRHLPLEGFPNSTMRKTRLWARFDAGATDPVNRPGWATTTPDH 481
Query 464 GLTIAVERWERMVPSTPVAGRHRHLAVLD-LGAHRALAQTLCAAIDSH-------PDTEL 515
+ + W+R PS+ + +AVL GA R A T+C SH PD
Sbjct 482 DVRVLRTEWQR--PSSRKLVAPQRIAVLTPAGADRGFAATICETAPSHGAVAWQLPDGGA 539
Query 516 SAAR-DAELILVIAPDFEHTDAVRA--AGALADLVG-AGLLDYPMHIGARCQSVCLVTVG 571
DA L+L+ A TD V A AG LAD GL + P + + T G
Sbjct 540 EIGEVDAALLLLPA----GTDDVEADLAGLLADEAWRGGLTELP-------AVLWVATTG 588
Query 572 AEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGF 631
E V D AA AA R + E + LDL PV G + VL
Sbjct 589 GETV-GPDEAADPFHAAAAAALRCLAVEQTGARVAQLDL------PVEGTASADDVLSAI 641
Query 632 ---GETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAE 688
GE+AL ++ + + L A + LD L V+++GG G +G+ A A
Sbjct 642 HVGGESAL--ALRDGVIHVKRLVPAEVPASHDLD---LAHVLISGGTGRVGLAMAERFAR 696
Query 689 HGARRIVLLSRRAAD---QATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGV-GAS 744
GARR+ LLSR D + TVA L ++ G + D+TD A+A GG+ +
Sbjct 697 DGARRLTLLSRSGGDDEARRTVARLTRRFGVSVDVVRIDLTDAV---AVADVLGGLRTVT 753
Query 745 LIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGG 804
VHAA + + +A V AKV GL ++++ P R L+CSS+ GG
Sbjct 754 TAVHAALDYVDRPLSAIDAADVHRALDAKVGGLGRILDALDESP--RVLVCSSLAATLGG 811
Query 805 HGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSG 864
Y+AANRLL+V AA+LRA G AV WGLW +G DA +ARV +G
Sbjct 812 RDQALYAAANRLLEVEAARLRAVGVDAAAVGWGLWA-------VQGPLDADGLARVTATG 864
Query 865 LRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLL------------------------D 900
+ MAPQ A++A L D V AA L+ LL D
Sbjct 865 VVPMAPQAALDAGLGIRGFDAQVMAASWPDLRALLAMTGTAALVSDVLDLVAGAPEVAED 924
Query 901 SRQFE------------RYE------GPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQES 942
R + YE GP + + D V +LA + +P + +++
Sbjct 925 PRPLDAPPAEVAEPETAEYETVAEQPGPAESGDLMTDLV-AELAVAMDLPTS-DIDPGAP 982
Query 943 LFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA 989
L LG+DS+ ALD R R++ S+ + + ++G + + +VA ++ A
Sbjct 983 LVALGMDSLQALDFRKRVQASLACDLPVEAILGGASLNEVVALMDTA 1029
>gi|317506260|ref|ZP_07964078.1| acyl transferase domain-containing protein [Segniliparus rugosus
ATCC BAA-974]
gi|316255438|gb|EFV14690.1| acyl transferase domain-containing protein [Segniliparus rugosus
ATCC BAA-974]
Length=909
Score = 358 bits (919), Expect = 3e-96, Method: Compositional matrix adjust.
Identities = 300/934 (33%), Positives = 432/934 (47%), Gaps = 94/934 (10%)
Query 111 MGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHA 170
MG V Y + P YR D CA AF A SPL YL+ ++ +A + A F
Sbjct 1 MGRVFYEQSPAYRAEADRCAQAFEAQLGMSPLDYLVREDAPEDDRARV---AQPALFTQM 57
Query 171 VALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPG-RYAV 229
LA +WR+ GV P T+GHS GE+AAAY++G +TL DAV+ V R+ G YA+
Sbjct 58 AGLAAMWRAAGVEPAFTIGHSQGEIAAAYVSGMVTLHDAVSAVGVRSAFADDFAGGDYAM 117
Query 230 AALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITV 289
A + ++A + GW +LSVVN+ + + VSG+R+ + VD + FAR I V
Sbjct 118 AVAAVSRDVCEEVLARSSGWAQLSVVNSPNMIGVSGDRETLQGFVDALAERDVFARMIRV 177
Query 290 GFPVHTSVLESLRDELCEQ----LPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLR 345
FP HTS + L + L F EA V +G T G + P G+YW+ NLR
Sbjct 178 RFPAHTSEIARLDERFAAAIDGALDHRVFAEAAVACVGSTFGGPITPEFQPGEYWFRNLR 237
Query 346 HTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERF 405
+TVRFD+AV SA + GA F+E++AHP L AI +N A D AV VG++ R
Sbjct 238 NTVRFDKAVASAAQLGADVFVELAAHPTLRMAIHENLGERAG--DEGAV-VGTSSRTAVG 294
Query 406 VDALSANIVSAAVADPGYPWGDLGGD-PLDGDVDLSGFPNAPMRAVPMW----------- 453
+D N+ + AV D Y W L + P L+ FPNAPMR + +W
Sbjct 295 LDEFVRNLATLAVRDLRYRWDRLREEVPGPPPAPLADFPNAPMRRLRLWLPYRTAGQQPV 354
Query 454 AHPEPLPPV----------SGLTIAVERWERMVPSTPVAGRHRHLAVLDLGAHRALAQTL 503
A P P + S + E W R+ S R + ++D H
Sbjct 355 AAPAQSPALAAEARREADGSDARLLAESWVRL--SQRSMTRPSAIGLID---HTGKCAAS 409
Query 504 CAAIDSHPDTELSAARDAE---------LILVIAPDFEHTDAVRAAGALADLVGAGLLDY 554
AA+ + + + AR E ++V+ P +A A A G D
Sbjct 410 AAALLAAAENYGATARVIEPSDDTAGLDTLVVLLPAASDEEAATAVADTASFFG----DR 465
Query 555 PMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWD 614
A ++ CLVT+G E V AD PS AA +A RS+G E P +F H+DL
Sbjct 466 AWWPEAGARACCLVTIGGESVTEADRPPSLAHAAASAGFRSVGVERPGVSFRHVDLDCEP 525
Query 615 LDPVLGVSVITAV-LRGFGETALRGS-VNGYTLFERTLADAPAVPNWSLDSGVLDDVVVT 672
L P ++I A+ G E ALRGS V L E + A+ P G D VV+T
Sbjct 526 LQPGAASALIAALHTAGEPELALRGSEVYAKRLVETSHAEQPV--------GRPDHVVIT 577
Query 673 GGAGAIGMHYARYLAEHGARRIVLLSRR--AADQATVAMLRKQHGTVIVSPPCDITDPTQ 730
GG G +G+ + + A GA+RI L+SR AA + +R I CD++D
Sbjct 578 GGTGKLGVEFCEHFAALGAKRISLVSRSGAAAGSDRLDRIRAATSARIELVACDVSDKDS 637
Query 731 LSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDV 790
+S +A L+VHAA +T+ AKVLG A E P D
Sbjct 638 VSQLARTLQDAPVDLLVHAAVDYADIELEDITTEKARRVLDAKVLGAAWACEALPRARDF 697
Query 791 RTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARG 850
R +LCSSV GG G Y+AANR+LD +A +LRA G C +V+WG W+
Sbjct 698 RVVLCSSVAATIGGRGQAVYAAANRMLDALATRLRADGTACASVQWGQWETHMD------ 751
Query 851 IADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGP 910
A + ++ SG+R + P QA+ + + +V A D + + +L+ + GP
Sbjct 752 -LGAHGLKKLAGSGIRPLRPAQALALGMSGSAANFIVAALDLDQARFVLEPYGY----GP 806
Query 911 TDPNLTIV--------------------DAVRTQLAAVLGIPQAGEVNLQESLFDLGVDS 950
L +++ A V+G AG +N+ + LG+DS
Sbjct 807 LLSGLVATAAPAQAAETGQAGPAKGGGPESLLAIFADVVGDGSAGSINVDAPMVALGLDS 866
Query 951 MLALDLRNRLKRSIGATVSLATLMGDITGDGLVA 984
+ AL+LR R+K +G +S+A ++ + L+A
Sbjct 867 LQALELRRRVKTELGHDLSIADMLAGASVKDLMA 900
>gi|152695|gb|AAA26495.1| ORF3 encoding modules 5 & 6 for 6-deoxyerythronolide B formation;
putative [Saccharopolyspora erythraea]
Length=3170
Score = 304 bits (778), Expect = 6e-80, Method: Compositional matrix adjust.
Identities = 320/1018 (32%), Positives = 451/1018 (45%), Gaps = 115/1018 (11%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L R P ++ + L R HRAV+ DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLAREPRNSLRDTGFTLATRRSAWEHRAVV-VGDRD 524
Query 69 ELAEGLRALAAGREHPLIARSSLGSAPRQ---AFVFPGQGGHWPGMGAVAYRELPTYRTA 125
+ GLRA+A GR + R++ G A + A VFPGQG W GM RE + +
Sbjct 525 DALAGLRAVADGR---IADRTATGQARTRRGVAMVFPGQGAQWQGMARDLLRESQVFADS 581
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 582 IRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEPA 636
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 637 AVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLARLGGQGGMASFGLGTEQAAERIGR 696
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
G L ++ VN +V V+GE + ++ + G AR I V + H+ +ESLR+EL
Sbjct 697 FAGALSIASVNGPRSVVVAGESGPLDELIAECEAEGITARRIPVDYASHSPQVESLREEL 756
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
+L + A V TTG + T YWYANLR VRF A G AF
Sbjct 757 LTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAF 816
Query 366 IEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYP 424
+E+S HP L I + A LP D A +VG+ RR + + A
Sbjct 817 VEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVD 874
Query 425 WGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMV-------P 477
W P D P P + W P+P + W V
Sbjct 875 W-----SPAFADARPVELPVYPFQRQRYWL---PIPTGGRARDEDDDWRYQVVWREAEWE 926
Query 478 STPVAGR----------HRHLAVLDLGAHRALAQTLCAAIDSHPD--TELSAARDAELIL 525
S +AGR + G ++ A L ++S T L AA L
Sbjct 927 SASLAGRVLLVTGPGVPSELSDAIRSGLEQSGATVLTCDVESRSTIGTALEAADTDALST 986
Query 526 VI---APDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVP 582
V+ + D E D A AL +GA ++ P+ + +T A QV + V
Sbjct 987 VVSLLSRDGEAVDPSLDALALVQALGAAGVEAPLWV---------LTRNAVQVADGELVD 1037
Query 583 SAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNG 642
A QA + + R +G E P + +DL D + ++ + A RG + A+R +G
Sbjct 1038 PA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSLAAVLADPRGEEQVAIR--ADG 1094
Query 643 YTLFERTLADAPAV-PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA 701
+ A A A WS VL VTGG G IG H AR+LA GA +VLL RR
Sbjct 1095 IKVARLVPAPARAARTRWSPRGTVL----VTGGTGGIGAHVARWLARSGAEHLVLLGRRG 1150
Query 702 ADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAI-AAEYG-GVGASLIVHAAGSVISG 756
AD + LR++ GT + CD+ D +L A+ AAE G S ++HAAG S
Sbjct 1151 ADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAERAEGRTVSAVMHAAGVSTST 1210
Query 757 TAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANR 815
+T A + KV G + EL PD+ L SS GVWG G+ +Y+AAN
Sbjct 1211 PLDDLTEAEFTEIADVKVRGTVNLDELC---PDLDAFVLFSSNAGVWGSPGLASYAAANA 1267
Query 816 LLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIE 875
LD A + R++G ++ WGLW AG+ G + GLR M P +A+E
Sbjct 1268 FLDGFARRRRSEGAPVTSIAWGLW----AGQNMAGDEGGEYL---RSQGLRAMDPDRAVE 1320
Query 876 ASLHEFTVD--------------PLVFAADAARLQMLLD--------SRQFERYEGP--- 910
LH T+D V AAR + L D +RQ E EGP
Sbjct 1321 -ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFDEIAGARAEARQSE--EGPALA 1376
Query 911 --------TDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
+ + +R ++AAVLG ++ + DLG DSM A+DLRNRL
Sbjct 1377 QRLAALSTAERREHLAHLIRAEVAAVLGHGDDAAIDRDRAFRDLGFDSMTAVDLRNRL 1434
Score = 239 bits (610), Expect = 2e-60, Method: Compositional matrix adjust.
Identities = 304/1005 (31%), Positives = 442/1005 (44%), Gaps = 120/1005 (11%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 1933 VPVLLSARTETALAAQARLLESAVD--DSVPLTALASALATGRAHLPRRAALLAGDHEQL 1990
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 1991 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 2048
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A S + A ++R +E ++ F V+LA +W +CGV P
Sbjct 2049 AVL------SEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 2102
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 2103 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 2162
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 2163 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 2222
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ YWY NLR VRFD AV +A+ G F+
Sbjct 2223 ADLDGISARRAAIPLYSTLHGERRDGADMGPRYWYDNLRSQVRFDEAVSAAVADGHATFV 2282
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 2283 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 2333
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 2334 NV--FPAAPPVALPNYPFEPQR---YWLAPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 2386
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVR-----AAG 541
L H + ++L +A+ E + R ++ V + D E + A+R AG
Sbjct 2387 FL------VHGSAPESLTSAV------EKAGGR---VVPVASADREASAALREVPGEVAG 2431
Query 542 ALADLVGAGL-LDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGFE 599
L+ GA L +G L V + V ++ P QA + + R +G E
Sbjct 2432 VLSVHTGAATHLALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGLE 2491
Query 600 HPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---AV 656
PE+ +DLP+ +P G G + ++ + + R L AP
Sbjct 2492 TPERWGGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTRE 2548
Query 657 PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ--- 713
+W L VTGG GA+G H AR+LA G +VL+SRR D A L +
Sbjct 2549 SSWEPAGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPGAAELEAELVA 2604
Query 714 HGTVIVSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNFA 771
G CD+ D QLS + E G G + +VH AG + + P + A
Sbjct 2605 LGAKTTITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVCA 2662
Query 772 AKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRH 830
AKV G + EL PD T L SS GVWG + AYSAAN LD +A + RA+GR
Sbjct 2663 AKVTGARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGRA 2719
Query 831 CVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLVF 888
+V WG W AGE G+A + + R GLR MAP++AI A LH+ D V
Sbjct 2720 ATSVAWGAW----AGE---GMATG-DLEGLTRRGLRPMAPERAIRA-LHQALDNGDTCVS 2770
Query 889 AAD-----------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVDA 920
AD AAR + LLD R+ E +++
Sbjct 2771 IADVDWEAFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLEF 2822
Query 921 VRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
+ +AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 2823 THSHVAAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 2867
>gi|134097330|ref|YP_001102991.1| EryAIII erythromycin polyketide synthase modules 5 and 6 [Saccharopolyspora
erythraea NRRL 2338]
gi|55419417|gb|AAV51822.1| EryAIII [Saccharopolyspora erythraea]
gi|133909953|emb|CAM00065.1| EryAIII Erythromycin polyketide synthase modules 5 and 6 [Saccharopolyspora
erythraea NRRL 2338]
Length=3171
Score = 303 bits (777), Expect = 8e-80, Method: Compositional matrix adjust.
Identities = 320/1018 (32%), Positives = 451/1018 (45%), Gaps = 115/1018 (11%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L R P ++ + L R HRAV+ DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLAREPRNSLRDTGFTLATRRSAWEHRAVV-VGDRD 524
Query 69 ELAEGLRALAAGREHPLIARSSLGSAPRQ---AFVFPGQGGHWPGMGAVAYRELPTYRTA 125
+ GLRA+A GR + R++ G A + A VFPGQG W GM RE + +
Sbjct 525 DALAGLRAVADGR---IADRTATGQARTRRGVAMVFPGQGAQWQGMARDLLRESQVFADS 581
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 582 IRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEPA 636
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 637 AVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIGR 696
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
G L ++ VN +V V+GE + ++ + G AR I V + H+ +ESLR+EL
Sbjct 697 FAGALSIASVNGPRSVVVAGESGPLDELIAECEAEGITARRIPVDYASHSPQVESLREEL 756
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
+L + A V TTG + T YWYANLR VRF A G AF
Sbjct 757 LTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAF 816
Query 366 IEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYP 424
+E+S HP L I + A LP D A +VG+ RR + + A
Sbjct 817 VEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVD 874
Query 425 WGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMV-------P 477
W P D P P + W P+P + W V
Sbjct 875 W-----SPAFADARPVELPVYPFQRQRYWL---PIPTGGRARDEDDDWRYQVVWREAEWE 926
Query 478 STPVAGR----------HRHLAVLDLGAHRALAQTLCAAIDSHPD--TELSAARDAELIL 525
S +AGR + G ++ A L ++S T L AA L
Sbjct 927 SASLAGRVLLVTGPGVPSELSDAIRSGLEQSGATVLTCDVESRSTIGTALEAADTDALST 986
Query 526 VI---APDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVP 582
V+ + D E D A AL +GA ++ P+ + +T A QV + V
Sbjct 987 VVSLLSRDGEAVDPSLDALALVQALGAAGVEAPLWV---------LTRNAVQVADGELVD 1037
Query 583 SAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNG 642
A QA + + R +G E P + +DL D + ++ + A RG + A+R +G
Sbjct 1038 PA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSLAAVLADPRGEEQVAIR--ADG 1094
Query 643 YTLFERTLADAPAV-PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA 701
+ A A A WS VL VTGG G IG H AR+LA GA +VLL RR
Sbjct 1095 IKVARLVPAPARAARTRWSPRGTVL----VTGGTGGIGAHVARWLARSGAEHLVLLGRRG 1150
Query 702 ADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAI-AAEYG-GVGASLIVHAAGSVISG 756
AD + LR++ GT + CD+ D +L A+ AAE G S ++HAAG S
Sbjct 1151 ADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAERAEGRTVSAVMHAAGVSTST 1210
Query 757 TAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANR 815
+T A + KV G + EL PD+ L SS GVWG G+ +Y+AAN
Sbjct 1211 PLDDLTEAEFTEIADVKVRGTVNLDELC---PDLDAFVLFSSNAGVWGSPGLASYAAANA 1267
Query 816 LLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIE 875
LD A + R++G ++ WGLW AG+ G + GLR M P +A+E
Sbjct 1268 FLDGFARRRRSEGAPVTSIAWGLW----AGQNMAGDEGGEYL---RSQGLRAMDPDRAVE 1320
Query 876 ASLHEFTVD--------------PLVFAADAARLQMLLD--------SRQFERYEGP--- 910
LH T+D V AAR + L D +RQ E EGP
Sbjct 1321 -ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFDEIAGARAEARQSE--EGPALA 1376
Query 911 --------TDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
+ + +R ++AAVLG ++ + DLG DSM A+DLRNRL
Sbjct 1377 QRLAALSTAERREHLAHLIRAEVAAVLGHGDDAAIDRDRAFRDLGFDSMTAVDLRNRL 1434
Score = 235 bits (599), Expect = 3e-59, Method: Compositional matrix adjust.
Identities = 303/1006 (31%), Positives = 439/1006 (44%), Gaps = 121/1006 (12%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 1933 VPVLLSARTETALAAQARLLESAVD--DSVPLTALASALATGRAHLPRRAALLAGDHEQL 1990
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 1991 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 2048
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A S + A ++R +E ++ F V+LA +W +CGV P
Sbjct 2049 AVL------SEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 2102
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 2103 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 2162
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 2163 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 2222
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ YWY NLR VRFD AV +A+ G F+
Sbjct 2223 ADLDGISARRAAIPLYSTLHGERRDGADMGPRYWYDNLRSQVRFDEAVSAAVADGHATFV 2282
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 2283 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 2333
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 2334 NV--FPAAPPVALPNYPFEPQR---YWLAPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 2386
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV------RAA 540
L H + ++L +A+ E + R ++ V + D E A A
Sbjct 2387 FL------VHGSAPESLTSAV------EKAGGR---VVPVASADREALAAALREVPGEVA 2431
Query 541 GALADLVGAGL-LDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGF 598
G L+ GA L +G L V + V ++ P QA + + R +G
Sbjct 2432 GVLSVHTGAATHLALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGL 2491
Query 599 EHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---A 655
E PE+ +DLP+ +P G G + ++ + + R L AP
Sbjct 2492 ETPERWGGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTR 2548
Query 656 VPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ-- 713
+W L VTGG GA+G H AR+LA G +VL+SRR D A L +
Sbjct 2549 ESSWEPAGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPGAAELEAELV 2604
Query 714 -HGTVIVSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNF 770
G CD+ D QLS + E G G + +VH AG + + P +
Sbjct 2605 ALGAKTTITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVC 2662
Query 771 AAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGR 829
AAKV G + EL PD T L SS GVWG + AYSAAN LD +A + RA+GR
Sbjct 2663 AAKVTGARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGR 2719
Query 830 HCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLV 887
+V WG W AGE G+A + + R GLR MAP++AI A LH+ D V
Sbjct 2720 AATSVAWGAW----AGE---GMATG-DLEGLTRRGLRPMAPERAIRA-LHQALDNGDTCV 2770
Query 888 FAAD-----------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVD 919
AD AAR + LLD R+ E +++
Sbjct 2771 SIADVDWERFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLE 2822
Query 920 AVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
+ +AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 2823 FTHSHVAAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 2868
>gi|291009650|ref|ZP_06567623.1| EryAIII erythromycin polyketide synthase modules 5 and 6 [Saccharopolyspora
erythraea NRRL 2338]
Length=1787
Score = 303 bits (777), Expect = 9e-80, Method: Compositional matrix adjust.
Identities = 320/1018 (32%), Positives = 451/1018 (45%), Gaps = 115/1018 (11%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L R P ++ + L R HRAV+ DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLAREPRNSLRDTGFTLATRRSAWEHRAVV-VGDRD 524
Query 69 ELAEGLRALAAGREHPLIARSSLGSAPRQ---AFVFPGQGGHWPGMGAVAYRELPTYRTA 125
+ GLRA+A GR + R++ G A + A VFPGQG W GM RE + +
Sbjct 525 DALAGLRAVADGR---IADRTATGQARTRRGVAMVFPGQGAQWQGMARDLLRESQVFADS 581
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 582 IRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEPA 636
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 637 AVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIGR 696
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
G L ++ VN +V V+GE + ++ + G AR I V + H+ +ESLR+EL
Sbjct 697 FAGALSIASVNGPRSVVVAGESGPLDELIAECEAEGITARRIPVDYASHSPQVESLREEL 756
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
+L + A V TTG + T YWYANLR VRF A G AF
Sbjct 757 LTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAF 816
Query 366 IEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARRGERFVDALSANIVSAAVADPGYP 424
+E+S HP L I + A LP D A +VG+ RR + + A
Sbjct 817 VEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVD 874
Query 425 WGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMV-------P 477
W P D P P + W P+P + W V
Sbjct 875 W-----SPAFADARPVELPVYPFQRQRYWL---PIPTGGRARDEDDDWRYQVVWREAEWE 926
Query 478 STPVAGR----------HRHLAVLDLGAHRALAQTLCAAIDSHPD--TELSAARDAELIL 525
S +AGR + G ++ A L ++S T L AA L
Sbjct 927 SASLAGRVLLVTGPGVPSELSDAIRSGLEQSGATVLTCDVESRSTIGTALEAADTDALST 986
Query 526 VI---APDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVP 582
V+ + D E D A AL +GA ++ P+ + +T A QV + V
Sbjct 987 VVSLLSRDGEAVDPSLDALALVQALGAAGVEAPLWV---------LTRNAVQVADGELVD 1037
Query 583 SAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNG 642
A QA + + R +G E P + +DL D + ++ + A RG + A+R +G
Sbjct 1038 PA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSLAAVLADPRGEEQVAIR--ADG 1094
Query 643 YTLFERTLADAPAV-PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA 701
+ A A A WS VL VTGG G IG H AR+LA GA +VLL RR
Sbjct 1095 IKVARLVPAPARAARTRWSPRGTVL----VTGGTGGIGAHVARWLARSGAEHLVLLGRRG 1150
Query 702 ADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAI-AAEYG-GVGASLIVHAAGSVISG 756
AD + LR++ GT + CD+ D +L A+ AAE G S ++HAAG S
Sbjct 1151 ADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAERAEGRTVSAVMHAAGVSTST 1210
Query 757 TAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANR 815
+T A + KV G + EL PD+ L SS GVWG G+ +Y+AAN
Sbjct 1211 PLDDLTEAEFTEIADVKVRGTVNLDELC---PDLDAFVLFSSNAGVWGSPGLASYAAANA 1267
Query 816 LLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIE 875
LD A + R++G ++ WGLW AG+ G + GLR M P +A+E
Sbjct 1268 FLDGFARRRRSEGAPVTSIAWGLW----AGQNMAGDEGGEYL---RSQGLRAMDPDRAVE 1320
Query 876 ASLHEFTVD--------------PLVFAADAARLQMLLD--------SRQFERYEGP--- 910
LH T+D V AAR + L D +RQ E EGP
Sbjct 1321 -ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFDEIAGARAEARQSE--EGPALA 1376
Query 911 --------TDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
+ + +R ++AAVLG ++ + DLG DSM A+DLRNRL
Sbjct 1377 QRLAALSTAERREHLAHLIRAEVAAVLGHGDDAAIDRDRAFRDLGFDSMTAVDLRNRL 1434
>gi|54778587|gb|AAV39552.1| EryAIII (morphed) [synthetic construct]
Length=3177
Score = 301 bits (772), Expect = 3e-79, Method: Compositional matrix adjust.
Identities = 329/1037 (32%), Positives = 460/1037 (45%), Gaps = 153/1037 (14%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L R P ++ + L R HRAV+ DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLAREPRNSLRDTGFTLATRRSAWEHRAVV-VGDRD 524
Query 69 ELAEGLRALAAGREHPLIARSSLGSAPRQ---AFVFPGQGGHWPGMGAVAYRELPTYRTA 125
+ GLRA+A GR + R++ G A + A VFPGQG W GM RE + +
Sbjct 525 DALAGLRAVADGR---IADRTATGQARTRRGVAMVFPGQGAQWQGMARDLLRESQVFADS 581
Query 126 TDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPD 185
C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 582 IRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEPA 636
Query 186 LTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT 245
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 637 AVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIGR 696
Query 246 TGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDEL 305
G L ++ VN +V V+GE + ++ + G AR I V + H+ +ESLR+EL
Sbjct 697 FAGALSIASVNGPRSVVVAGESGPLDELIAECEAEGITARRIPVDYASHSPQVESLREEL 756
Query 306 CEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAF 365
+L + A V TTG + T YWYANLR VRF A G AF
Sbjct 757 LTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFDAF 816
Query 366 IEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARR------------GERFVDALSAN 412
+E+S HP L I + A LP D A +VG+ RR GE + + +
Sbjct 817 VEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVEVD 874
Query 413 IVSAAVAD------PGYP------WGDL--GGDPLDGDVDLSGFPNAPMRAVPMWAHPEP 458
S A AD P YP W + GG D D D R +W E
Sbjct 875 W-SPAFADARPVELPVYPFQRQRYWLQIPTGGRARDEDDD--------WRYQVVWREAE- 924
Query 459 LPPVSGLTIAVERWERMVPSTPVAGR----------HRHLAVLDLGAHRALAQTLCAAID 508
WE S +AGR + G ++ A L ++
Sbjct 925 -------------WE----SASLAGRVLLVTGPGVPSELSDAIRSGLEQSGATVLTCDVE 967
Query 509 SHPD--TELSAARDAELILVI---APDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQ 563
S T L AA L V+ + D E D A AL +GA ++ P+ +
Sbjct 968 SRSTIGTALEAADTDALSTVVSLLSRDGEAVDPSLDALALVQALGAAGVEAPLWV----- 1022
Query 564 SVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSV 623
+T A QV + V A QA + + R +G E P + +DL D + ++
Sbjct 1023 ----LTRNAVQVADGELVDPA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSLAA 1077
Query 624 ITAVLRGFGETALRGSVNGYTLFERTLADAPAV-PNWSLDSGVLDDVVVTGGAGAIGMHY 682
+ A RG + A+R +G + A A A WS VL VTGG G IG H
Sbjct 1078 VLADPRGEEQVAIR--ADGIKVARLVPAPARAARTRWSPRGTVL----VTGGTGGIGAHV 1131
Query 683 ARYLAEHGARRIVLLSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAI-AAEY 738
AR+LA GA +VLL RR AD + LR++ GT + CD+ D +L A+ AAE
Sbjct 1132 ARWLARSGAEHLVLLGRRGADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAER 1191
Query 739 G-GVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL-LCS 796
G S ++HAAG S +T A + KV G + EL PD+ L S
Sbjct 1192 AEGRTVSAVMHAAGVSTSTPLDDLTEAEFTEIADVKVRGTVNLDELC---PDLDAFVLFS 1248
Query 797 SVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVT 856
S GVWG G+ +Y+AAN LD A + R++G ++ WGLW AG+ G
Sbjct 1249 SNAGVWGSPGLASYAAANAFLDGFARRRRSEGAPVTSIAWGLW----AGQNMAGDEGGEY 1304
Query 857 IARVERSGLRQMAPQQAIEASLHEFTVD--------------PLVFAADAARLQMLLD-- 900
+ GLR M P +A+E LH T+D V AAR + L D
Sbjct 1305 L---RSQGLRAMDPDRAVE-ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFDEI 1359
Query 901 ------SRQFERYEGP-----------TDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESL 943
+RQ E EGP + + +R ++AAVLG ++ +
Sbjct 1360 AGARAEARQSE--EGPALAQRLAALSTAERREHLAHLIRAEVAAVLGHGDDAAIDRDRAF 1417
Query 944 FDLGVDSMLALDLRNRL 960
DLG DSM A+DLRNRL
Sbjct 1418 RDLGFDSMTAVDLRNRL 1434
Score = 236 bits (601), Expect = 2e-59, Method: Compositional matrix adjust.
Identities = 303/1006 (31%), Positives = 439/1006 (44%), Gaps = 121/1006 (12%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 1933 VPVLLSARTETALAAQARLLESAVD--DSVPLTALASALATGRAHLPRRAALLAGDHEQL 1990
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 1991 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 2048
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A S + A ++R +E ++ F V+LA +W +CGV P
Sbjct 2049 AVL------SEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 2102
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 2103 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 2162
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 2163 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 2222
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ YWY NLR VRFD AV +A+ G F+
Sbjct 2223 ADLDGISARRAAIPLYSTLHGERRDGADMGPRYWYDNLRSQVRFDEAVSAAVADGHATFV 2282
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 2283 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 2333
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 2334 NV--FPAAPPVALPNYPFEPQR---YWLQPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 2386
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV------RAA 540
L H + ++L +A+ E + R ++ V + D E A A
Sbjct 2387 FL------VHGSAPESLTSAV------EKAGGR---VVPVASADREALAAALREVPGEVA 2431
Query 541 GALADLVGAGL-LDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGF 598
G L+ GA L +G L V + V ++ P QA + + R +G
Sbjct 2432 GVLSVHTGAATHLALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGL 2491
Query 599 EHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---A 655
E PE+ +DLP+ +P G G + ++ + + R L AP
Sbjct 2492 ETPERWGGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTR 2548
Query 656 VPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ-- 713
+W L VTGG GA+G H AR+LA G +VL+SRR D A L +
Sbjct 2549 ESSWEPAGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPGAAELEAELV 2604
Query 714 -HGTVIVSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNF 770
G CD+ D QLS + E G G + +VH AG + + P +
Sbjct 2605 ALGAKTTITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVC 2662
Query 771 AAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGR 829
AAKV G + EL PD T L SS GVWG + AYSAAN LD +A + RA+GR
Sbjct 2663 AAKVTGARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGR 2719
Query 830 HCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLV 887
+V WG W AGE G+A + + R GLR MAP++AI A LH+ D V
Sbjct 2720 AATSVAWGAW----AGE---GMATG-DLEGLTRRGLRPMAPERAIRA-LHQALDNGDTCV 2770
Query 888 FAAD-----------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVD 919
AD AAR + LLD R+ E +++
Sbjct 2771 SIADVDWERFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLE 2822
Query 920 AVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
+ +AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 2823 FTHSHVAAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 2868
>gi|2506137|sp|Q03133.4|ERYA3_SACER RecName: Full=Erythronolide synthase, modules 5 and 6; AltName:
Full=6-deoxyerythronolide B synthase III; AltName: Full=DEBS
3; AltName: Full=ORF 3
gi|46979|emb|CAA44449.1| 6-deoxyerythronolide B synthase III [Saccharopolyspora erythraea
NRRL 2338]
Length=3172
Score = 288 bits (737), Expect = 3e-75, Method: Compositional matrix adjust.
Identities = 322/1045 (31%), Positives = 454/1045 (44%), Gaps = 156/1045 (14%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L P ++ + L HRAV+ DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLAPEPRNSLRDTGFTLATRASAMEHRAVV-VGDRD 524
Query 69 ELAEGLRALAAGREHPLIARSSLGSAP----RQAFVFPGQGGHWPGMGAVAYRELPTYRT 124
E GLRA+A R + R++ G P R A VFPGQG W GM RE +
Sbjct 525 EALAGLRAVADRR---IADRTATGQGPNSPRRVAMVFPGQGAQWQGMARDLLRESQVFAD 581
Query 125 ATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLP 184
+ C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 582 SIRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEP 636
Query 185 DLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIA 244
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 637 AAVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIG 696
Query 245 TTGGWLELSVVNA-SSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRD 303
G L ++ VN S V V+GE + ++ + H AR I V + H+ +ESLR+
Sbjct 697 RFAGALSIASVNGPRSVVVVAGESGPLDELIAECEAEAHKARRIPVDYASHSPQVESLRE 756
Query 304 ELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGAR 363
EL +L + A V TTG + T YWYANLR VRF A G
Sbjct 757 ELLTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFD 816
Query 364 AFIEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARR------------GERFVDALS 410
AF+E+S HP L I + A LP D A +VG+ RR GE + +
Sbjct 817 AFVEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVE 874
Query 411 ANIVSAAVAD------PGYPWGDL------GGDPLDGDVDLSGFPNAPMRAVPMWAHPEP 458
+ S A AD P YP+ GG D D D R +W E
Sbjct 875 VDW-SPAFADARPVELPVYPFQRYWLPIPTGGRARDEDDD--------WRYQVVWREAE- 924
Query 459 LPPVSGLTIAVERWERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAA 518
WE S +AGR L V G L+ + + ++ T L+
Sbjct 925 -------------WE----SASLAGRV--LLVTGPGVPSELSDAIRSGLEQSGATVLTCD 965
Query 519 RDAELILVIAPDFEHTDAVRAAG-----------------ALADLVGAGLLDYPMHIGAR 561
++ + A + TDA+ G AL +GA ++ P+ +
Sbjct 966 VESRSTIGTALEAADTDALSTVGVAAVPHGEAVDPSLDALALVQALGAAGVEAPLWV--- 1022
Query 562 CQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGV 621
+T A QV + V A QA + + R +G E P + +DL D + +
Sbjct 1023 ------LTRNAVQVADGELVDPA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRSL 1075
Query 622 SVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMH 681
+ + A RG + A+R +G + L APA + V+VTGG G IG H
Sbjct 1076 AAVLADPRGEEQVAIR--ADGIKVAR--LVPAPARARTHPLEPLAGTVLVTGGTGGIGAH 1131
Query 682 YARYLAEHGARRIVLLSRRAADQATVAMLRKQH---GTVIVSPPCDITDPTQLSAIAAEY 738
AR+LA GA +VLL RR AD + LR++ GT + CD+ D +L A+ A
Sbjct 1132 LARWLARSGAEHLVLLGRRGADAPGASELREELTALGTGVTIAACDVADRARLEAVLAAE 1191
Query 739 G---GVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL-L 794
G S ++HAAG S +T A + KV G + EL P D+ L
Sbjct 1192 AAAEGRTVSAVMHAAGVSTSTPLDDLTEAEFTEIADVKVRGTVNLDELCP---DLDAFVL 1248
Query 795 CSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADA 854
SS GVWG G+ +Y+AAN LD A R++G ++ WGLW AG+ G
Sbjct 1249 FSSNAGVWGSPGLASYAAANAFLDGFARAARSEGAPVTSIAWGLW----AGQNMAGDEGG 1304
Query 855 VTIARVERSGLRQMAPQQAIEASLHEFTVDP--------------LVFAADAARLQMLLD 900
+ GLR M P +A+E LH T+D V AAR + L D
Sbjct 1305 EYL---RSQGLRAMDPDRAVE-ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLFD 1359
Query 901 --------SRQFERYEGPTDPNLT------------IVDAVRTQLAAVLGIPQAGEVNLQ 940
+RQ E EGP + +R ++AAVLG ++
Sbjct 1360 EIAGARAEARQSE--EGPALAQRLAALLCDGREREHLAHLIRAEVAAVLGHGDDAAIDRD 1417
Query 941 ESLFDLGVDSMLALDLRNRLKRSIG 965
+ DLG DSM A+DLRNRL G
Sbjct 1418 RAFRDLGFDSMTAVDLRNRLAAVTG 1442
Score = 227 bits (579), Expect = 7e-57, Method: Compositional matrix adjust.
Identities = 299/1000 (30%), Positives = 433/1000 (44%), Gaps = 113/1000 (11%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 1938 VPVLLSARTETALAAQARLLESAVDD--SVPLTALASALATGRAHLPRRAALLAGDHEQL 1995
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 1996 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 2053
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A S + A ++R +E ++ F V+LA +W +CGV P
Sbjct 2054 AVL------SEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 2107
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 2108 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 2167
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 2168 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 2227
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ G YWY NLR VRFD AV + G F+
Sbjct 2228 ADLDGISARRAAIPLYSTLHGERRDMGPR---YWYDNLRSQVRFDEAVSAQSPDGHATFV 2284
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 2285 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 2335
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 2336 NV--FPAAPPVALPNYPFEPQR---YWLAPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 2388
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADL 546
L H + ++L +A++ A+ D E + + AG L+
Sbjct 2389 FL------VHGSAPESLTSAVEKAGGVVPVASADREALAAALREVPG----EVAGVLSVH 2438
Query 547 VG-AGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGFEHPEQT 604
G A L +G L V + V ++ P QA + + R +G E PE+
Sbjct 2439 TGAANALALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGLETPERW 2498
Query 605 FSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---AVPNWSL 661
+DLP+ +P G G + ++ + + R L AP +W
Sbjct 2499 GGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTRESSWEP 2555
Query 662 DSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD---QATVAMLRKQHGTVI 718
L VTGG GA+G H AR+LA G +VL+SRR D A + G
Sbjct 2556 AGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPAAAELEAELVALGPKT 2611
Query 719 VSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNFAAKVLG 776
CD+ D QLS + E G G + +VH AG + + P + AAKV G
Sbjct 2612 TITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVCAAKVTG 2669
Query 777 LAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVK 835
+ EL PD T L SS GVWG + AYSAAN LD +A + RA+GR +V
Sbjct 2670 ARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGRAATSVA 2726
Query 836 WGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLVFAAD-- 891
WG W AGE G+A + + R GLR MAP +AI A LH+ D V AD
Sbjct 2727 WGAW----AGE---GMATG-DLEGLTRRGLRPMAPDRAIRA-LHQALDNGDTCVSIADVD 2777
Query 892 ---------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVDAVRTQL 925
AAR + LLD R+ E +++ + +
Sbjct 2778 WEAFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLEFTHSHV 2829
Query 926 AAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 2830 AAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 2869
>gi|10179854|gb|AAG13919.1|AF263245_15 megalomicin 6-deoxyerythronolide B synthase 3 [Micromonospora
megalomicea subsp. nigra]
Length=3201
Score = 280 bits (715), Expect = 1e-72, Method: Compositional matrix adjust.
Identities = 325/1044 (32%), Positives = 454/1044 (44%), Gaps = 122/1044 (11%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
VA++ SA E + A +AD L PA ++ + A L R HRAV+ E+
Sbjct 488 VALVFSARDERALRAQAARLADRLTDDPAPSLRDTAFTLVTRRATWEHRAVVVGGGE-EV 546
Query 71 AEGLRALAAGR--EHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDT 128
GLRA+A GR + + R+ G R VFPGQG W GM R+ PT+ + D
Sbjct 547 LAGLRAVAGGRPVDGAVSGRARAGR--RVVLVFPGQGAQWQGMARDLLRQSPTFAESIDA 604
Query 129 CAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEI-EGAQFVHAVALAEVWRSCGVLPDLT 187
C A A VD L ++ D Q+ +++ + F V+LA +W+S GV P
Sbjct 605 CERALAPH-VDWSLREVL-----DGEQSLDPVDVVQPVLFAVMVSLARLWQSYGVTPGAV 658
Query 188 VGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTG 247
VGHS GE+AAA++AG+++L+DA VVA R+ V+ RL G +A+ G+ A+ IA
Sbjct 659 VGHSQGEIAAAHVAGALSLADAARVVALRSRVLRRLGGHGGMASFGLHPDQAAERIARFA 718
Query 248 GWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCE 307
G L ++ VN +V ++GE + ++ + G AR I V + H+ +ESLR+EL
Sbjct 719 GALTVASVNGPRSVVLAGENGPLDELIAECEAEGVTARRIPVDYASHSPQVESLREELLA 778
Query 308 QLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIE 367
L + A + TG V+ T DYW+ANLR VRF A G AF+E
Sbjct 779 ALAGVRPVSAGIPLYSTLTGQVIETATMDADYWFANLREPVRFQDATRQLAEAGFDAFVE 838
Query 368 ISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPGY 423
+S HP L + E A PD + G+ RR +F AL+ D
Sbjct 839 VSPHPVLTVGVEATLE-AVLPPDADPCVTGTLRRERGGLAQFHTALAEAYTRGVEVDWRT 897
Query 424 PWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLP-PVSGLTIAVERWERMVPSTPVA 482
G+ G P+D P P + W LP P+ + + W + PV
Sbjct 898 AVGE--GRPVD-------LPVYPFQRQNFW-----LPVPLGRVPDTGDEWRYQLAWHPVD 943
Query 483 GRHRHLA------------------VLDLGAHRALAQTLC---------AAIDSHPDTEL 515
LA V D R LC AA+D+ T L
Sbjct 944 LGRSSLAGRVLVVTGAAVPPAWTDVVRDGLEQRGATVVLCTAQSRARIGAALDAVDGTAL 1003
Query 516 SAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQV 575
S +L +A D AL +GA +D P+ + R VTVG + V
Sbjct 1004 STVVS---LLALAEGGAVDDPSLDTLALVQALGAAGIDVPLWLVTR--DAAAVTVG-DDV 1057
Query 576 DAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETA 635
D A QA + + R +G E P + +DL D D ++ I A RG + A
Sbjct 1058 DPA-------QAMVGGLGRVVGVESPARWGGLVDLREADADSARSLAAILADPRGEEQFA 1110
Query 636 LRGSVNGYTLFERTLADAPAV-PNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRI 694
+R +G T+ A A A W+ VL VTGG G IG H AR+LA GA +
Sbjct 1111 IR--PDGVTVARLVPAPARAAGTRWTPRGTVL----VTGGTGGIGAHLARWLAGAGAEHL 1164
Query 695 VLLSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAI--AAEYGGVGASLIVHA 749
VLL+RR A+ A A LR + GT + CD+ D +L+A+ AA G + + HA
Sbjct 1165 VLLNRRGAEAAGAADLRDELVALGTGVTITACDVADRDRLAAVLDAARAQGRVVTAVFHA 1224
Query 750 AGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVA 809
AG S +T + + AKV G A + EL P + +L SS VWG G+ +
Sbjct 1225 AGISRSTAVQELTESEFTEITDAKVRGTANLAELCPELDAL--VLFSSNAAVWGSPGLAS 1282
Query 810 YSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMA 869
Y+A N LD A + R G ++ WGLW AG+ G + GLR M
Sbjct 1283 YAAGNAFLDAFARRGRRSGLPVTSIAWGLW----AGQNMAGTEGGDYL---RSQGLRAMD 1335
Query 870 PQQAIEASLHEFTV-DPLVFAAD-----------AARLQMLLDSRQFER---YEGPTDPN 914
PQ+AIE DP V D AAR + L D R E + +
Sbjct 1336 PQRAIEELRTTLDAGDPWVSVVDLDRERFVELFTAARRRPLFDELGGVRAGAEETGQESD 1395
Query 915 LT--------------IVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
L + VR ++AAVLG + + DLG DSM A+DLRNRL
Sbjct 1396 LARRLASMPEAERHEHVARLVRAEVAAVLGHGTPTVIERDVAFRDLGFDSMTAVDLRNRL 1455
Query 961 KRSIGATVSLATLMGDITGDGLVA 984
G V+ + T D L A
Sbjct 1456 AAVTGVRVATTIVFDHPTVDRLTA 1479
Score = 247 bits (630), Expect = 9e-63, Method: Compositional matrix adjust.
Identities = 315/1040 (31%), Positives = 450/1040 (44%), Gaps = 134/1040 (12%)
Query 15 LSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGL 74
LSA E + AR + D ++ A + VA L R +RA L A D EL + L
Sbjct 1964 LSAKTETALTELARRLHDAVDDTVA--LPAVAATLATGRAHLPYRAALLARDHDELRDRL 2021
Query 75 RALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFA 134
RA G P + S + S FVFPGQGG W GM A +P + + C A +
Sbjct 2022 RAFTTGSAAPGVV-SGVASGGGVVFVFPGQGGQWVGM-ARGLLSVPVFVESVVECDAVVS 2079
Query 135 AAGVDSPLPYLIAPPGTDERQAFCEIEI-EGAQFVHAVALAEVWRSCGVLPDLTVGHSLG 193
+ S L L G + +++ + FV V+LA +WR CGV+P VGHS G
Sbjct 2080 SVVGFSVLGVLEGRSGA---PSLDRVDVVQPVLFVVMVSLARLWRWCGVVPAAVVGHSQG 2136
Query 194 EVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELS 253
E+AAA +AG +++ D VVA RA + L G + +L + + A LIA + ++
Sbjct 2137 EIAAAVVAGVLSVGDGARVVALRARALRALAGHGGMVSLAVSAERARELIAPWSDRISVA 2196
Query 254 VVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSE 313
VN+ ++V VSG+ QA+AA+V +G A+ + V + H++ +E +RD + L D
Sbjct 2197 AVNSPTSVVVSGDPQALAALVAHCAETGERAKTLPVDYASHSAHVEQIRDTILTDLADVT 2256
Query 314 FMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPA 373
V G A YWY NLR VRFD AVE+A+ G R F+E+S HP
Sbjct 2257 ARRPDVALYSTLHGARGAGTDMDARYWYDNLRSPVRFDEAVEAAVADGYRVFVEMSPHPV 2316
Query 374 LLFAIGQNCEGAANLPDGPAVLVGSARR--GERFVDALSANIVSAAVADPGYPWGDLGGD 431
L A+ + D V +GS R GER L A + A V G
Sbjct 2317 LTAAVQEI--------DDETVAIGSLHRDTGERH---LVAELARAHVH----------GV 2355
Query 432 PLDGDVDLSG-----FPNAPMRAVPMWAHPEPLPPVSGLTIAVERWE---RMVPSTPVAG 483
P+D L PN P A W L P + +A R+ R + +TP
Sbjct 2356 PVDWRAILPATHPVPLPNYPFEATRYW-----LAPTAADQVADHRYRVDWRPLATTPAEL 2410
Query 484 RHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV--RAAG 541
+L D +TL +++ L+ V APD E AAG
Sbjct 2411 SGSYLVFGD------APETLGHSVEKA---------GGLLVPVAAPDRESLAVALDEAAG 2455
Query 542 ALADLVGAGLLDYPMHIGARCQ---------SVCLVTVGAEQVDAADAVPSAGQAALAAM 592
LA ++ D H+ AR + + LVT G +D D + QA + +
Sbjct 2456 RLAGVLSFA-ADTATHL-ARHRLLGEADVEAPLWLVTSGGVALDDHDPI-DCDQAMVWGI 2512
Query 593 HRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLAD 652
R +G E P + +D+ ++P V+ A L + + ++ R L
Sbjct 2513 GRVMGLETPHRWGGLVDV---TVEPTAEDGVVFAALLAADDHEDQVALRDGIRHGRRLVR 2569
Query 653 APAVP---NWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAM 709
AP W+ L VTGG GA+G H ARYLA G +VLLSR D A
Sbjct 2570 APLTTRNARWTPAGTAL----VTGGTGALGGHVARYLARSGVTDLVLLSRSGPDAPGAAE 2625
Query 710 LRKQHGTVIVSP---PCDITDPTQLSAIAAEYGGVG--ASLIVHAAGSVISGTAPGVTSA 764
L + + P CD+TD +L A+ E ++VH AG + + P
Sbjct 2626 LAAELADLGAEPRVEACDVTDGPRLRALVQELREQDRPVRIVVHTAG--VPDSRPLDRID 2683
Query 765 AVVDNFAAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQ 823
+ AAKV G + EL PD T L SS GVWG + AY+AAN LD +A +
Sbjct 2684 ELESVSAAKVTGARLLDELC---PDADTFVLFSSGAGVWGSANLGAYAAANAYLDALAHR 2740
Query 824 LRAQGRHCVAVKWGLWQAPKAGEP-ARGIADAVTIARVERSGLRQMAPQQAIEASLHEFT 882
R GR +V WG W AG+ A G D +T R GLR MAP +A+ A +T
Sbjct 2741 RRQAGRAATSVAWGAW----AGDGMATGDLDGLT-----RRGLRAMAPDRALRACTRRWT 2791
Query 883 V-DPLVFAAD-----------AARLQMLLDSRQFERYEGPTDPNLT---------IVDAV 921
D V AD AAR + L+D ++
Sbjct 2792 THDTCVSVADVDWDRFAVGFTAARPRPLIDELVTSAPVAAPTAAAAPVPAMTADQLLQFT 2851
Query 922 RTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDG 981
R+ +AA+LG V L + +LG DS+ A+ LRN+L+++ G T+ A + T
Sbjct 2852 RSHVAAILGHQDPDAVGLDQPFTELGFDSLTAVGLRNQLQQATGRTLPAALVFQHPT--- 2908
Query 982 LVAKLEDADERSHTAQKVDI 1001
V +L D H AQ++D+
Sbjct 2909 -VRRLAD-----HLAQQLDV 2922
>gi|30313904|gb|AAO49807.1| polyketide synthase [Mycobacterium smegmatis]
Length=360
Score = 274 bits (700), Expect = 7e-71, Method: Compositional matrix adjust.
Identities = 171/366 (47%), Positives = 223/366 (61%), Gaps = 31/366 (8%)
Query 652 DAPAVPNWS--------LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD 703
D P P ++ + +GVLDDVV+TGG GA+G+ +AR LA GARRIVLLSR +
Sbjct 2 DNPVAPRYARRVGRGSAVATGVLDDVVITGGTGAVGLQFARRLAGLGARRIVLLSRNGIE 61
Query 704 QATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTS 763
V L G IV+P CD+TD ++ +AAE+GG GASLIVHAA + +T
Sbjct 62 GNRVDEL--PLGVEIVAPRCDLTDIPRVRDVAAEFGGQGASLIVHAAATATIAAGSALTG 119
Query 764 AAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQ 823
AA F AK+ G+ ++ WP+RPD R LLCSSV G+WGGHG A +AANRLLDVMA +
Sbjct 120 AAAQATFTAKLAGIENVLAAWPVRPDARILLCSSVSGLWGGHGHAARTAANRLLDVMAER 179
Query 824 LRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTV 883
LR++GR C AV+WGLW P GI DA I RVERSGLR MAP +A++ +L +F
Sbjct 180 LRSEGRRCTAVRWGLW-------PGAGIIDADEITRVERSGLRAMAPDRAVDTALQDFRG 232
Query 884 DPLVFAADAARLQMLLDSR-------------QFERYEGPTD-PNLTIVDAVRTQLAAVL 929
DPLVF+ADA RL + L + Q P D + AVR LAAVL
Sbjct 233 DPLVFSADAQRLALFLGTDPDTGTGREATHAAQHRDAGPPADAEHHDTGAAVRIALAAVL 292
Query 930 GIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLEDA 989
+ ++L SL DLGVDS+LALDLR +LK++ G +V LATL+G +T L+ LE
Sbjct 293 KLADTTGLDLDASLLDLGVDSLLALDLRKKLKKTTGRSVPLATLLGGVTATELIEHLERP 352
Query 990 DERSHT 995
++ + +
Sbjct 353 EKETFS 358
>gi|46976|emb|CAA39583.1| 6-deoxyerythronolide B synthase [Saccharopolyspora erythraea
NRRL 2338]
Length=3178
Score = 267 bits (683), Expect = 6e-69, Method: Compositional matrix adjust.
Identities = 315/1046 (31%), Positives = 449/1046 (43%), Gaps = 152/1046 (14%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L A+ T A + + + DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLA---ASRGTRCATPVSRWPPAAAPWEQVVVGDRD 522
Query 69 ELAEGLRALAAGREHPLIARSSLGSAP----RQAFVFPGQGGHWPGMGAVAYRELPTYRT 124
E GLRA+A R + R++ G P R A VFPGQG W GM RE +
Sbjct 523 EALAGLRAVADRR---IADRTATGQGPNSPRRVAMVFPGQGAQWQGMARDLLRESQVFAD 579
Query 125 ATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLP 184
+ C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 580 SIRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEP 634
Query 185 DLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIA 244
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 635 AAVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIG 694
Query 245 TTGGWLELSVVNA-SSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRD 303
G L ++ VN S V V+GE + ++ + H AR I V + H+ +ESLR+
Sbjct 695 RFAGALSIASVNGPRSVVVVAGESGPLDELIAECEAEAHKARRIPVDYASHSPQVESLRE 754
Query 304 ELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGAR 363
EL +L + A V TTG + T YWYANLR VRF A G
Sbjct 755 ELLTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFD 814
Query 364 AFIEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARR------------GERFVDALS 410
AF+E+S HP L I + A LP D A +VG+ RR GE + +
Sbjct 815 AFVEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVE 872
Query 411 ANIVSAAVAD------PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSG 464
+ S A AD P YP+ P P + W P+P
Sbjct 873 VDW-SPAFADARPVELPVYPF-------------QRELPVYPFQRQRYWL---PIPTGGR 915
Query 465 LTIAVERWERMV-------PSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSA 517
+ W V S +AGR L V G L+ + + ++ T L+
Sbjct 916 ARDEDDDWRYQVVWREAEWESASLAGRV--LLVTGPGVPSELSDAIRSGLEQSGATVLTC 973
Query 518 ARDAELILVIAPDFEHTDAVRAAG-----------------ALADLVGAGLLDYPMHIGA 560
++ + A + TDA+ G AL +GA ++ P+ +
Sbjct 974 DVESRSTIGTALEAADTDALSTVGVAAVPHGEAVDPSLDALALVQALGAAGVEAPLWV-- 1031
Query 561 RCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLG 620
+T A QV + V A QA + + R +G E P + +DL D +
Sbjct 1032 -------LTRNAVQVADGELVDPA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRS 1083
Query 621 VSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGM 680
++ + A RG + A+R +G + L APA + V+VTGG IG
Sbjct 1084 LAAVLADPRGEEQVAIR--ADGIKVAR--LVPAPARARTHPLEPLAGTVLVTGG---IGA 1136
Query 681 HYARYLAEHGARRIVLLSRRAADQATVAMLRKQH---GTVIVSPPCDITDPTQLSAIAAE 737
H AR+LA GA +VLL RR AD + LR++ GT + CD+ D +L A+ A
Sbjct 1137 HLARWLARSGAEHLVLLGRRGADAPGASELREELTALGTGVTIAACDVADRARLEAVLAA 1196
Query 738 YG---GVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL- 793
G S ++HAAG S +T A + KV G + EL P D+
Sbjct 1197 EAAAEGRTVSAVMHAAGVSTSTPLDDLTEAEFTEIADVKVRGTVNLDELCP---DLDAFV 1253
Query 794 LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIAD 853
L SS GVWG G+ +Y+AAN LD A R++G ++ WGLW AG+ G
Sbjct 1254 LFSSNAGVWGSPGLASYAAANAFLDGFARAARSEGAPVTSIAWGLW----AGQNMAGDEG 1309
Query 854 AVTIARVERSGLRQMAPQQAIEASLHEFTVDP--------------LVFAADAARLQMLL 899
+ GLR M P +A+E LH T+D V AAR + L
Sbjct 1310 GEYL---RSQGLRAMDPDRAVE-ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLF 1364
Query 900 D--------SRQFERYEGPTDPNLT------------IVDAVRTQLAAVLGIPQAGEVNL 939
D +RQ E EGP + +R ++AAVLG ++
Sbjct 1365 DEIAGARAEARQSE--EGPALAQRLAALLCDGREREHLAHLIRAEVAAVLGHGDDAAIDR 1422
Query 940 QESLFDLGVDSMLALDLRNRLKRSIG 965
+ DLG DSM A+DLRNRL G
Sbjct 1423 DRAFRDLGFDSMTAVDLRNRLAAVTG 1448
Score = 216 bits (550), Expect = 2e-53, Method: Compositional matrix adjust.
Identities = 295/1000 (30%), Positives = 429/1000 (43%), Gaps = 113/1000 (11%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 1944 VPVLLSARTETALAAQARLLESAVDD--SVPLTALASALATGRAHLPRRAALLAGDHEQL 2001
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 2002 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 2059
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A S + A ++R +E ++ F V+LA +W +CGV P
Sbjct 2060 AVL------SEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 2113
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 2114 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 2173
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 2174 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 2233
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ G YWY NLR VRFD AV + G F+
Sbjct 2234 ADLDGISARRAAIPLYSTLHGERRDMGPR---YWYDNLRSQVRFDEAVSAQSPDGHATFV 2290
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 2291 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 2341
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 2342 NV--FPAAPPVALPNYPFEPQR---YWLAPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 2394
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADL 546
L H + ++L +A++ A+ D E + + AG L+
Sbjct 2395 FL------VHGSAPESLTSAVEKAGGVVPVASADREALAAALREVPG----EVAGVLSVH 2444
Query 547 VG-AGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGFEHPEQT 604
G A L +G L V + V ++ P QA + + R +G E PE+
Sbjct 2445 TGAANALALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGLETPERW 2504
Query 605 FSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---AVPNWSL 661
+DLP+ +P G G + ++ + + R L AP +W
Sbjct 2505 GGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTRESSWEP 2561
Query 662 DSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD---QATVAMLRKQHGTVI 718
L VTGG GA+G H AR+LA G +VL+SRR D A + G
Sbjct 2562 AGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPAAAELEAELVALGPKT 2617
Query 719 VSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNFAAKVLG 776
CD+ D QLS + E G G + +VH AG + + P + AAKV G
Sbjct 2618 TITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVCAAKVTG 2675
Query 777 LAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVK 835
+ EL PD T L SS GVWG + AYSAAN LD +A + + +V
Sbjct 2676 ARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRAVRKAVRRTSVA 2732
Query 836 WGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLVFAAD-- 891
WG W AGE G+A + + R GLR MAP +AI A LH+ D V AD
Sbjct 2733 WGAW----AGE---GMATG-DLEGLTRRGLRPMAPDRAIRA-LHQALDNGDTCVSIADVD 2783
Query 892 ---------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVDAVRTQL 925
AAR + LLD R+ E +++ + +
Sbjct 2784 WEAFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLEFTHSHV 2835
Query 926 AAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 2836 AAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 2875
>gi|227367|prf||1702361A polyketide synthase
Length=3177
Score = 267 bits (683), Expect = 7e-69, Method: Compositional matrix adjust.
Identities = 315/1046 (31%), Positives = 449/1046 (43%), Gaps = 152/1046 (14%)
Query 9 GRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRL 68
G V ++LS E+ + A +AD+L A+ T A + + + DR
Sbjct 466 GPVPLVLSGRDEQAMRAQAGRLADHLA---ASRGTRCATPVSRWPPAAAPWEQVVVGDRD 522
Query 69 ELAEGLRALAAGREHPLIARSSLGSAP----RQAFVFPGQGGHWPGMGAVAYRELPTYRT 124
E GLRA+A R + R++ G P R A VFPGQG W GM RE +
Sbjct 523 EALAGLRAVADRR---IADRTATGQGPNSPRRVAMVFPGQGAQWQGMARDLLRESQVFAD 579
Query 125 ATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLP 184
+ C A A VD L L++ +R ++ A F V+LA +WRS GV P
Sbjct 580 SIRDCERALAPH-VDWSLTDLLSGARPLDRVDV----VQPALFAVMVSLAALWRSHGVEP 634
Query 185 DLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIA 244
VGHS GE+AAA++AG++TL DA +VA R+ V+ RL G+ +A+ G+G + A+ I
Sbjct 635 AAVVGHSQGEIAAAHVAGALTLEDAAKLVAVRSRVLRRLGGQGGMASFGLGTEQAAERIG 694
Query 245 TTGGWLELSVVNA-SSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRD 303
G L ++ VN S V V+GE + ++ + H AR I V + H+ +ESLR+
Sbjct 695 RFAGALSIASVNGPRSVVVVAGESGPLDELIAECEAEAHKARRIPVDYASHSPQVESLRE 754
Query 304 ELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGAR 363
EL +L + A V TTG + T YWYANLR VRF A G
Sbjct 755 ELLTELAGISPVSADVALYSTTTGQPIDTATMDTAYWYANLREQVRFQDATRQLAEAGFD 814
Query 364 AFIEISAHPALLFAIGQNCEGAANLP-DGPAVLVGSARR------------GERFVDALS 410
AF+E+S HP L I + A LP D A +VG+ RR GE + +
Sbjct 815 AFVEVSPHPVLTVGIEATLDSA--LPADAGACVVGTLRRDRGGLADFHTALGEAYAQGVE 872
Query 411 ANIVSAAVAD------PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSG 464
+ S A AD P YP+ P P + W P+P
Sbjct 873 VDW-SPAFADARPVELPVYPF-------------QRELPVYPFQRQRYWL---PIPTGGR 915
Query 465 LTIAVERWERMV-------PSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSA 517
+ W V S +AG R L V G L+ + + ++ T L+
Sbjct 916 ARDEDDDWRYQVVWREAEWESASLAG--RVLLVTGPGVPSELSDAIRSGLEQSGATVLTC 973
Query 518 ARDAELILVIAPDFEHTDAVRAAG-----------------ALADLVGAGLLDYPMHIGA 560
++ + A + TDA+ G AL +GA ++ P+ +
Sbjct 974 DVESRSTIGTALEAADTDALSTVGVAAVPHGEAVDPSLDALALVQALGAAGVEAPLWV-- 1031
Query 561 RCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLG 620
+T A QV + V A QA + + R +G E P + +DL D +
Sbjct 1032 -------LTRNAVQVADGELVDPA-QAMVGGLGRVVGIEQPGRWGGLVDLVDADAASIRS 1083
Query 621 VSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGM 680
++ + A RG + A+R +G + L APA + V+VTGG IG
Sbjct 1084 LAAVLADPRGEEQVAIR--ADGIKVAR--LVPAPARARTHPLEPLAGTVLVTGG---IGA 1136
Query 681 HYARYLAEHGARRIVLLSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQ---LSAI 734
H AR+LA GA +VLL RR AD + LR++ GT + CD+ D + + A
Sbjct 1137 HLARWLARSGAEHLVLLGRRGADAPGASELREELTALGTGVTIAACDVADRARLEAVLAA 1196
Query 735 AAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL- 793
A G S ++HAAG S +T A + KV G + EL PD+
Sbjct 1197 EAAAEGRTVSAVMHAAGVSTSTPLDDLTEAEFTEIADVKVRGTVNLDELC---PDLDAFV 1253
Query 794 LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIAD 853
L SS GVWG G+ +Y+AAN LD A R++G ++ WGLW AG+ G
Sbjct 1254 LFSSNAGVWGSPGLASYAAANAFLDGFARAARSEGAPVTSIAWGLW----AGQNMAGDEG 1309
Query 854 AVTIARVERSGLRQMAPQQAIEASLHEFTVDP--------------LVFAADAARLQMLL 899
+ GLR M P +A+E LH T+D V AAR + L
Sbjct 1310 GEYL---RSQGLRAMDPDRAVE-ELH-ITLDHGQTSVSVVDMDRRRFVELFTAARHRPLF 1364
Query 900 D--------SRQFERYEGPTDPNLT------------IVDAVRTQLAAVLGIPQAGEVNL 939
D +RQ E EGP L + +R ++AAVLG ++
Sbjct 1365 DEIAGARAEARQSE--EGPALAQLRAALLCDGREREHLAHLIRAEVAAVLGHGDDAAIDR 1422
Query 940 QESLFDLGVDSMLALDLRNRLKRSIG 965
+ DLG DSM A+DLRNRL G
Sbjct 1423 DRAFRDLGFDSMTAVDLRNRLAAVTG 1448
Score = 216 bits (550), Expect = 2e-53, Method: Compositional matrix adjust.
Identities = 295/1000 (30%), Positives = 429/1000 (43%), Gaps = 113/1000 (11%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 1944 VPVLLSARTETALAAQARLLESAVDD--SVPLTALASALATGRAHLPRRAALLAGDHEQL 2001
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 2002 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 2059
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A S + A ++R +E ++ F V+LA +W +CGV P
Sbjct 2060 AVL------SEVAGFSASEVLEQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 2113
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 2114 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 2173
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 2174 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 2233
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ G YWY NLR VRFD AV + G F+
Sbjct 2234 ADLDGISARRAAIPLYSTLHGERRDMGPR---YWYDNLRSQVRFDEAVSAQSPDGHATFV 2290
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 2291 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 2341
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 2342 NV--FPAAPPVALPNYPFEPQR---YWLAPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 2394
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGALADL 546
L H + ++L +A++ A+ D E + + AG L+
Sbjct 2395 FL------VHGSAPESLTSAVEKAGGVVPVASADREALAAALREVPG----EVAGVLSVH 2444
Query 547 VG-AGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGFEHPEQT 604
G A L +G L V + V ++ P QA + + R +G E PE+
Sbjct 2445 TGAANALALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGLETPERW 2504
Query 605 FSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---AVPNWSL 661
+DLP+ +P G G + ++ + + R L AP +W
Sbjct 2505 GGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTRESSWEP 2561
Query 662 DSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD---QATVAMLRKQHGTVI 718
L VTGG GA+G H AR+LA G +VL+SRR D A + G
Sbjct 2562 AGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPAAAELEAELVALGPKT 2617
Query 719 VSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNFAAKVLG 776
CD+ D QLS + E G G + +VH AG + + P + AAKV G
Sbjct 2618 TITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVCAAKVTG 2675
Query 777 LAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVK 835
+ EL PD T L SS GVWG + AYSAAN LD +A + + +V
Sbjct 2676 ARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRAVRKAVRRTSVA 2732
Query 836 WGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLVFAAD-- 891
WG W AGE G+A + + R GLR MAP +AI A LH+ D V AD
Sbjct 2733 WGAW----AGE---GMATG-DLEGLTRRGLRPMAPDRAIRA-LHQALDNGDTCVSIADVD 2783
Query 892 ---------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVDAVRTQL 925
AAR + LLD R+ E +++ + +
Sbjct 2784 WEAFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLEFTHSHV 2835
Query 926 AAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 2836 AAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 2875
>gi|291434986|ref|ZP_06574376.1| type I modular polyketide synthase [Streptomyces ghanaensis ATCC
14672]
gi|291337881|gb|EFE64837.1| type I modular polyketide synthase [Streptomyces ghanaensis ATCC
14672]
Length=4652
Score = 260 bits (665), Expect = 8e-67, Method: Compositional matrix adjust.
Identities = 308/1014 (31%), Positives = 432/1014 (43%), Gaps = 145/1014 (14%)
Query 29 AIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPLIAR 88
A+A+ L +V L TR +R+V+ D + GL AG + P+ A
Sbjct 1926 ALAERLRPLAGENPVDVGHTL-ATRTAFEYRSVVVGQDAEDWTAGL----AGLDRPVAA- 1979
Query 89 SSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAP 148
R FVFPGQG WPGM P + C A A VD LP ++
Sbjct 1980 ----GVGRTVFVFPGQGSQWPGMAVELLESSPVFAARFAQCERALAPF-VDWSLPEVLRS 2034
Query 149 PGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSD 208
D ++ + V+LA +W + GV PD GHS GE+AAA +AG+++L D
Sbjct 2035 GDYDRVDV-----VQPVLWAVMVSLAALWEAAGVRPDAVAGHSQGEIAAAVVAGALSLED 2089
Query 209 AVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQ 268
VVA R+ + L GR + ++ + + AL+ + ++ VN S+V V+G+
Sbjct 2090 GARVVALRSRAITVLAGRGGMVSVPLPADEVRALLPEG---VAVAAVNGPSSVVVAGD-- 2144
Query 269 AVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGD 328
A ++TV +S AR I V + H++ +E +R ++ + L A V F T
Sbjct 2145 --VAGLETVLASVQRARRIPVDYASHSAHVEEIRRQILDLLAPVSPRTASVPFF-STVDA 2201
Query 329 VVAPGTTF-GDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAAN 387
A GT YWY NLR TV F+ AV G AFIE+S HP L I + E +
Sbjct 2202 QWADGTGLDAGYWYRNLRRTVEFEAAVRKLADAGFGAFIEVSPHPVLTMPIEETAE---D 2258
Query 388 LPDGPAVL-VGSARRGE----RFVDALSANIVSAAVADPG--YPWGDLGGDPLDGDVDLS 440
+ PA+L VG+ RR + RF+ +L D YP G L
Sbjct 2259 IGGDPALLAVGTLRRDQGGLRRFMTSLGTAWAHGVDVDTAALYPGG-----------RLV 2307
Query 441 GFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR-----HLAVLD--- 492
P P + W P P P VS + W V P A R LAV+
Sbjct 2308 ALPTYPFQRERYWLAP-PSPEVS-----TDSWRYRVTWRPAAPEARPLPGTWLAVVPEGH 2361
Query 493 ------LGAHRALAQTLCAAIDSH--------------------PDTELSAARDAELILV 526
+GA RAL + A ++ + P+ LS AEL
Sbjct 2362 REDAWVVGALRALTER-GARVEEYVVPAGTRRQELAAALADRARPEGVLSLLALAEL--- 2417
Query 527 IAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQ 586
PD EH G A L +L +H + +T GA + Q
Sbjct 2418 --PDPEHP------GLTAGLALTTVLTQALHDTGWTAPLWCLTRGATSAAGEGDLRHPAQ 2469
Query 587 AALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLF 646
AA+ + R IG EHPE +DLP+ D D + + VL G G+ + V G T
Sbjct 2470 AAVWGLGRVIGLEHPEFWGGLVDLPA-DHDE-RSAAELCDVLAGGGDED-QWVVRGGTTL 2526
Query 647 ERTLADA-----PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA 701
R L A PA W VL VTG GA+G + AR+LA GA +VL RR
Sbjct 2527 VRRLTRAPRDGRPARRAWHPRGTVL----VTGATGAVGPYIARWLAAAGAEHLVLAGRRG 2582
Query 702 ADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISG 756
AD A L + GT + CD+TD T ++A+ A G + +VHAA +
Sbjct 2583 ADVPGAAELTAELAGSGTRLEYTVCDVTDRTAVAALVARLDAAGTPVRAVVHAAALIQIA 2642
Query 757 TAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRT-LLCSSVMGVWGGHGVVAYSAANR 815
+ + D AKV G + EL PD+ T LL SS+ GVWG AY+AAN
Sbjct 2643 SLADTSLTEFEDVVHAKVAGAVHLAELL---PDLDTFLLFSSIAGVWGSGDHGAYAAANA 2699
Query 816 LLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIE 875
LD A LR +G ++ WG+W P E A + RV R GL + P+ A+
Sbjct 2700 FLDAFAEHLRGRGTPATSIAWGIWNTPNLVESA-AMPGGPDTDRVRRQGLPFIDPEAAV- 2757
Query 876 ASLHEFTVDPLVFAADA-------------ARLQMLLD--------SRQFERYEGPTDPN 914
A+L D F A A AR + LLD +++ P
Sbjct 2758 AALQRAMDDDETFLAVADVDWSRFAPVFTSARPRPLLDEIPEVAEQAQEETSAAAPVAAQ 2817
Query 915 LT---IVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
L+ +V VR Q+A+VLG A V+ + + D+G DS+ A++LRNRL + G
Sbjct 2818 LSEAELVTLVREQVASVLGHSGADAVDPRRAFRDIGFDSLTAVELRNRLNSATG 2871
Score = 139 bits (349), Expect = 3e-30, Method: Compositional matrix adjust.
Identities = 121/353 (35%), Positives = 170/353 (49%), Gaps = 19/353 (5%)
Query 53 RRVRRHRAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMG 112
R V HRAV+ ELA GLRA+AAG A R FVFPGQG WPGM
Sbjct 3386 RPVFEHRAVVVGGAAGELAAGLRAVAAGEPLTGTAAGVAAGVGRTVFVFPGQGSQWPGMA 3445
Query 113 AVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVA 172
P + C A A VD LP ++ D ++ + V+
Sbjct 3446 VELLESSPVFAARFAQCERALAPF-VDWSLPEVLRSGDYDRVDV-----VQPVLWAVMVS 3499
Query 173 LAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAAL 232
LA +W + GV PD GHS GE+AAA +AG+++L D VVA R+ + L GR + ++
Sbjct 3500 LAALWEAAGVRPDAVAGHSQGEIAAAVVAGALSLEDGARVVALRSRAITVLAGRGGMVSV 3559
Query 233 GIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFP 292
+ + AL+ + ++ VN S+V V+G+ A ++TV +S AR I V +
Sbjct 3560 PLPADEVRALLPEG---VAVAAVNGPSSVVVAGD----VAGLETVLASVQRARRIPVDYA 3612
Query 293 VHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTF-GDYWYANLRHTVRFD 351
H++ +E +R ++ + L A V F T A GT YWY NLR TV F+
Sbjct 3613 SHSAHVEEIRRQILDLLAPVSPRTASVPFF-STVDAQWADGTGLDAGYWYRNLRRTVEFE 3671
Query 352 RAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVL-VGSARRGE 403
AV G AFIE+S HP L I + E ++ PA+L VG+ RR +
Sbjct 3672 AAVRKLADAGFGAFIEVSPHPVLTMPIEETAE---DIGGDPALLAVGTLRRDQ 3721
Score = 137 bits (345), Expect = 9e-30, Method: Compositional matrix adjust.
Identities = 101/310 (33%), Positives = 146/310 (48%), Gaps = 18/310 (5%)
Query 96 RQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQ 155
R FVFPGQG WPGM P + C A VD L ++ D
Sbjct 11 RTVFVFPGQGSQWPGMAVELLESSPVFAARFAQCERALTPF-VDWSLTEVLRSGDFDRVD 69
Query 156 AFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAA 215
++ F V+LA +W+ GV PD VGHS GE+AAA +AG+++L D VVA
Sbjct 70 V-----VQPVLFAVMVSLAALWQVAGVRPDAVVGHSQGEIAAAVVAGALSLEDGARVVAL 124
Query 216 RANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAI-- 273
R+ + L GR +A++ + Q+A I G L ++ VN S+V V+G+ A+ +
Sbjct 125 RSKALNALAGRGGMASVALSAQEARRRI---GPGLSVAAVNGPSSVVVAGDTDALDTLDT 181
Query 274 VDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPG 333
D VR R + V + H++ +E +R+EL L A + F TG ++
Sbjct 182 WDDVR-----VRRVPVDYASHSAHVEEIREELLTTLAGLTPRSAEIPFYSTVTGGLLDTA 236
Query 334 TTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPA 393
DYWY NLR TV + V + G F+E+S HP L AI + E D
Sbjct 237 ALDADYWYRNLRRTVELETTVRALGAAGHDVFVEVSPHPVLTSAIEETVEDIGG--DIAV 294
Query 394 VLVGSARRGE 403
+ VG+ RR +
Sbjct 295 LAVGTLRRDQ 304
Score = 84.7 bits (208), Expect = 9e-14, Method: Compositional matrix adjust.
Identities = 101/362 (28%), Positives = 157/362 (44%), Gaps = 65/362 (17%)
Query 669 VVVTGGAGAIGMHYARYL-AEHGARRIVLLSRRAADQATVAMLRKQHGTVIVSPPCDITD 727
V+ TGG+G + A +L AEHG R +V+LSR A G + S CD++D
Sbjct 1117 VLFTGGSGVLAGLVAEHLVAEHGIRHLVMLSRSGAAPQIA-------GADVRSVACDVSD 1169
Query 728 PTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLR 787
L+ + + +VH AG + G +T + F AKV + EL +
Sbjct 1170 RDALAEVLNTLDRP-LTAVVHTAGVLDDGVLADLTPERLDRVFRAKVDAALHLHELTRDQ 1228
Query 788 PDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEP 847
+L SS G +G G Y+AAN LD +A RA+G ++ WG+W + ++G
Sbjct 1229 DLAAFVLFSSAAGSFGAPGQANYAAANAFLDGLAQHRRAEGLPAQSMAWGMW-SQRSGLT 1287
Query 848 ARGIADAVTIARVERSGLRQMAPQQ-------------------------------AIEA 876
AR D +AR+ RSG+ ++ +Q A+
Sbjct 1288 AR--LDDGDVARMARSGMTPLSSEQGLALFDAALATDLAAPVMVRVDHDALRRQEEALSP 1345
Query 877 SLHEFTVDPLVFAADAARLQMLLDSR-------QFERYEGPTDPNLTIVDAVRTQLAAVL 929
L P+ AA A L R + +RY ++D VR+ A VL
Sbjct 1346 VLRGLVRAPVRRAATGAGAGSSLGDRLAAMPEPERQRY---------VLDLVRSAAAVVL 1396
Query 930 GIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGD-----ITGDGLVA 984
G V ++ +LG DS+ A++LRNRL ++ G +S+ TL+ D + G L+A
Sbjct 1397 GHVSPDLVEAGKTFRELGFDSLTAVELRNRLTKATGLKLSV-TLVFDYPTPAVLGAHLLA 1455
Query 985 KL 986
+L
Sbjct 1456 EL 1457
Score = 68.6 bits (166), Expect = 5e-09, Method: Compositional matrix adjust.
Identities = 126/464 (28%), Positives = 193/464 (42%), Gaps = 62/464 (13%)
Query 563 QSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDL-PSWDLDPVLGV 621
+ + VT GA DAV A++ + R+ EHP Q F +DL P D+ L V
Sbjct 4128 RRLVFVTRGAAGPGVRDAV----HASVWGLVRAAQIEHPNQ-FVLMDLGPDDDVTQWLPV 4182
Query 622 SVITAVLRGFGETALRGSVNGYTLFERTLADAPA--VPNWSLDSGVLDDVVVTGGAGAIG 679
AV G + A+R +G L R + AP P W + VL +TG +G +G
Sbjct 4183 ----AVAGGEPQVAVR---DGAVLAARLVRAAPTGEEPKWDPNGTVL----ITGASGVLG 4231
Query 680 MHYARYLAE-HGARRIVLLSRRAADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEY 738
AR+L + H R +VL++R D V L V CD D T ++ + A
Sbjct 4232 GLTARHLVDRHNVRDLVLVARSGPDPELVEELTAAGARVAAVR-CDAADRTAMAEVIA-- 4288
Query 739 GGVGA----SLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLL 794
G+ A + +VHAAG + +T V K + EL +L
Sbjct 4289 -GIPADRPLTGVVHAAGVLDDAPVTSLTPEQVDRVLRPKADAALLLDELTRGLQLSAFVL 4347
Query 795 CSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADA 854
SS +G G Y+AAN LD +A + RA G ++ WG W+ A G+ D
Sbjct 4348 FSSASATFGAAGQANYAAANAFLDALAERRRAAGLPAQSLGWGFWEQRSA--MTGGLGDR 4405
Query 855 VTIARVERSGLR---------------------------QMAPQQAIEASLHEFTVDPLV 887
+AR+ G+R ++P+ L V P V
Sbjct 4406 -EVARLASGGVRPIGSADGLALFDVASAMDDAVLVPIHLDLSPRGGEVPPLLRHLVRPAV 4464
Query 888 FAADAARLQMLLDSRQF-ERYEG-PTDPNL-TIVDAVRTQLAAVLGIPQAGEVNLQESLF 944
A + D+ F +R EG P + +++D VR+ +A V+ V+ +
Sbjct 4465 RRTQAV-AEGSADATTFRQRLEGLPEEAQRESLLDLVRSAVAGVVAYDGPASVDPDMTFM 4523
Query 945 DLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLED 988
+LG DS++A++LRNRL ++G ++ + T GL L D
Sbjct 4524 NLGFDSLMAVELRNRLSAAVGTRLTPTLVFDYPTASGLAGYLYD 4567
>gi|296141979|ref|YP_003649221.1| Acyl transferase [Tsukamurella paurometabola DSM 20162]
gi|296030113|gb|ADG80882.1| Acyl transferase [Tsukamurella paurometabola DSM 20162]
Length=1042
Score = 256 bits (655), Expect = 1e-65, Method: Compositional matrix adjust.
Identities = 333/1049 (32%), Positives = 473/1049 (46%), Gaps = 117/1049 (11%)
Query 6 LPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAA 65
LPDG A +LSA + + A + YL P + VA L TR +RRHRA++
Sbjct 25 LPDGLPAFVLSADGADSLAAAAAQLRRYLTEHPQVPLPAVAAALVATRDLRRHRAIVHTD 84
Query 66 DRLELAEGLRALAAGREHPLIA-----RSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP 120
DR EL L ALAA P+ + + +A AFVFPGQG GMGA+ +RE
Sbjct 85 DRGELVTALDALAADPVRPVGTAVPGLHTGVAAAGAPAFVFPGQGSQRRGMGALFHRESA 144
Query 121 TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDE-RQAFCEIEIEGAQ---FVHAVALAEV 176
YR + A S YL+ GT E Q + +E Q F+ A+ LA +
Sbjct 145 VYRDTVEKIHAIALEVFGSSARDYLL---GTGEWEQGGRPVPVEVVQPAIFMQALGLAAM 201
Query 177 WRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVV-GRLPGRYAVAALGIG 235
WR+ G+ P + VGHS GE+AAA AG++ L+D + +V RA V P +++A LG
Sbjct 202 WRAAGIEPRIHVGHSQGEIAAAVAAGTVGLADGLRLVTRRALAVRDNAPTGHSMAVLGTD 261
Query 236 EQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHT 295
+ +A++A T G+ ELSVVN++ + VSGER VA +V G FAR I V +P HT
Sbjct 262 RERCAAMLARTVGFAELSVVNSAHVLCVSGERDVVAGLVAQATERGIFAREIRVEYPAHT 321
Query 296 SVLES---LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDR 352
S++ S LR++ + F+ IGGT G+ V T F DYW+ NL++ VRFD
Sbjct 322 SLVGSMWHLREKWMGVMDHPAFLPTEHLLIGGTLGEAVPADTDFLDYWFWNLKNPVRFDL 381
Query 353 AVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSAN 412
A +A+ GA IE++ HP L A+ +N A A + GS+RR DA +
Sbjct 382 ATRAALDAGADRLIELAEHPTLQLALHENIADAGAR----ATVTGSSRR-----DATDLS 432
Query 413 IVSAAVADPGYPWGDLGGDPLDGDVDLS--------GFPNAPMRAVPMWA----HPEPLP 460
S+AVAD L D DV + GFP AP+ +WA P
Sbjct 433 EFSSAVADV------LVTHARDLDVQRTLVAEELPPGFPAAPLSRQRLWAALPGRPATAG 486
Query 461 PVSGLTIAVER-WERMVPSTPVAGRHRHLAVLD-LGAHRALAQTLCAAIDSH--PDTELS 516
PV T ++ W + PV+ R LA++D GAH LA L A + P
Sbjct 487 PVRPRTRVLDTVWTDL--DAPVSAPPRPLAIIDPTGAHADLAAALLDAAARYGTPARRSD 544
Query 517 AARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGAR-CQSVCLVTVGAEQV 575
A D E+ +V+ P TD AA VG L D G + + VT GA
Sbjct 545 RAGDDEIAVVLVPGSAETDTTIAA------VGELLADRRWWAGVQPAAGIAAVTAGAVVA 598
Query 576 DAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAV-LRGFGET 634
D AD P AA+A R+ G + P HLDL + I A+ + G
Sbjct 599 DPADPGPDGAAAAIAVGFRAFGADLPGVEVRHLDLDPRADAAAQAGTAIHALHVAGEPRL 658
Query 635 ALRGSVNGYTLFERTLADAPAVPNWSLDSGVLD---DVVVTGGAGAIGMHYARYLAEHGA 691
ALR +G ER + P +G+L+ +VV++GG G +G+ +A + A HGA
Sbjct 659 ALR---SGAVRAERWVDAEPTETGTEPPAGLLETARNVVISGGTGHLGLAFAAHAAAHGA 715
Query 692 RRIVLLSRRAAD----QATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIV 747
+ LLSR A + R+ + PCD+TDP ++ A G L+V
Sbjct 716 ASVTLLSRSGGGTTVRHALARIARRHPACAVTVVPCDVTDPAAVATALAGAGR-AIDLVV 774
Query 748 HAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGV 807
HAA A + ++ AAKV GL + + PD L CSS G G
Sbjct 775 HAAVGYRRCAATDLDASDFTAAAAAKVGGLRTLAQA---VPDATLLTCSSAAAALPGAGQ 831
Query 808 VAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQ 867
Y+A+N L + AA LR GR AV+WGLW+ G D A V +G+
Sbjct 832 AWYAASNTLAEAEAAALRRAGRRAAAVRWGLWEQ-------AGPLDEAGFAAVTAAGVIP 884
Query 868 MAPQQAIEASLHEFTVDPLVFAADAARLQ----------MLLDSRQFERYEGP------- 910
+A A+ A +P++ A D RL+ +L D + P
Sbjct 885 LAAPDALAALARSTGPEPVITAVDLPRLRDVAAAFGAAALLTDLTEDTTPAVPAPSDAVP 944
Query 911 -TDPN--------------------LTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVD 949
T P+ + +R LA L +P A ++ +L LG+D
Sbjct 945 GTAPDAPATVTVTTDAAPGPAPGGGADVAAVLRHHLARALAVP-ADTLDPDVALVALGLD 1003
Query 950 SMLALDLRNRLKRSIGATVSLATLMGDIT 978
S+ AL+LR ++ + A + L ++G T
Sbjct 1004 SLQALELRTAVRDELDAELPLEAILGGAT 1032
>gi|45934795|gb|AAS79459.1| polyketide synthase subunit [Streptomyces bikiniensis]
Length=4441
Score = 249 bits (635), Expect = 2e-63, Method: Compositional matrix adjust.
Identities = 292/1012 (29%), Positives = 410/1012 (41%), Gaps = 126/1012 (12%)
Query 52 TRRVRRHRAVLRAADRLELAEGLRALAAGREHP-LIARSSLGSAPRQAFVFPGQGGHWPG 110
+R V HR+V+ A D EL GL ALAA P L++ + G R FVFPGQG W G
Sbjct 1544 SRSVFEHRSVVLAGDSAELNAGLDALAADGVSPVLVSGVASGEGGRSVFVFPGQGTQWAG 1603
Query 111 MGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHA 170
M + E + + C AAFA V+ L ++ ER ++ A F
Sbjct 1604 MALGLWAESAVFAESMARCEAAFAGL-VEWRLADVLGDGSALERVDV----VQPASFAVM 1658
Query 171 VALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGR-LPGRYAV 229
V+LAE+WRS GV+PD VGHS GE+AAA +AG ++L D VV RA ++GR L GR +
Sbjct 1659 VSLAELWRSLGVVPDAVVGHSQGEIAAAVVAGGLSLEDGARVVVLRARLIGRELAGRGGM 1718
Query 230 AALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITV 289
A++ + +A G L ++VVN S V+G+ AV V G AR + V
Sbjct 1719 ASVALPVAVVEERLAGWAGRLGVAVVNGPSATVVAGDVDAVGEFVTACEVEGVRARVLPV 1778
Query 290 GFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVR 349
+ H++ +E L+ EL + L + + F + + YW+ NLR VR
Sbjct 1779 DYASHSAHVEDLKAELEQILAGIGPVTGGIPFYSTSEAAQIDTAGLDAGYWFGNLRRPVR 1838
Query 350 FDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDAL 409
F VE + G R F+E AHP L A+ + E VGS RR E +
Sbjct 1839 FQETVERLLADGFRVFVECGAHPVLTGAVQETAESTGR----QVCAVGSLRRDEGGLRRF 1894
Query 410 SANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPV------S 463
+ A V G W L VDL P P + W P V
Sbjct 1895 LTSAAEAFVQGVGVSWPALFDGTGARTVDL---PTYPFQRRRYWLESRPPAAVVPSGVQD 1951
Query 464 GLTIAV--------------ERWERMVPSTPVAGRHR--HLAVLDLGAHRALAQTLCAAI 507
GL+ V RW +VP T A R H L H A + +
Sbjct 1952 GLSYEVVWKSLPVRESSRLDGRWLLVVPETLDADGTRIAHDLQHALTTHGATVSRVSVDV 2011
Query 508 DSHPDTELSA------ARDAELILVIAPDFEHTDAVRAAG-----------ALADLVGAG 550
+ +LSA A D E + + + VRA G AL VG
Sbjct 2012 TTIDRADLSARLTTSAAEDQEPLGRVVSLLGWAEGVRAHGPNVPTSVAASLALVQAVGDA 2071
Query 551 LLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDL 610
P V VT GA V + VP A L A+ R G E P++ +DL
Sbjct 2072 GFGVP---------VWAVTRGAVSVVPGE-VPETAGAQLWALGRVAGLELPDRWGGLIDL 2121
Query 611 PSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP------AVPNWSLDSG 664
P+ D D + A+ G + + +V + R + A A W
Sbjct 2122 PA-DADARTAGLAVRALAAGIADGEDQVAVRPSGAYGRRVVQAAHREPSGAKTEWRPRGT 2180
Query 665 VLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLR---KQHGTVIVSP 721
VL VTGG GAIG AR+LA +GA +VL RR A L + G +
Sbjct 2181 VL----VTGGMGAIGTRVARWLARNGAEHLVLTGRRGAGTPGADELAGELRASGVQVTLA 2236
Query 722 PCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMI 781
CD++D L+A+ + + + H AG + GT +T A + + K +
Sbjct 2237 ACDVSDRAALAALLDAHP---PTAVFHTAGVLNDGTVDTLTPAHLDGVLSPKATAAVHLH 2293
Query 782 ELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQA 841
EL +L +SV GVWG G Y+ AN LD +A Q RA G ++ WGLW
Sbjct 2294 ELTAHLDLDAFVLFASVTGVWGNGGQAGYAMANAALDALAEQRRAGGLAATSISWGLWGG 2353
Query 842 PKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFT----------VDPLVFA-- 889
E ++ + R G+R + P IEA VD FA
Sbjct 2354 GGMAEGDGEVS-------LNRRGIRALEPATGIEALQRTLDQGATCRTVVDVDWGQFAPR 2406
Query 890 ----------ADAARLQMLLDSRQFERYE-GPTDPNLTI----------------VDAVR 922
AD ++ +L+S R + G +P + V+ VR
Sbjct 2407 TAALRRGRLFADLPEVRRVLESEGVAREDAGTVEPGAVLAERLASRSEAEQRRMLVELVR 2466
Query 923 TQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLM 974
+ AAVL + + S D G DS+ AL+LRNRL + G + + +
Sbjct 2467 AEAAAVLRHDTTDLLAPRRSFKDAGFDSLTALELRNRLNTATGVVLPVTVVF 2518
Score = 167 bits (423), Expect = 1e-38, Method: Compositional matrix adjust.
Identities = 121/354 (35%), Positives = 172/354 (49%), Gaps = 12/354 (3%)
Query 52 TRRVRRHRAVLRAADRLELAEGLRALAAGREHPLIAR--SSLGSAPRQAFVFPGQGGHWP 109
+R V HR+V+ A D EL+ GL ALAA P++ +S+G R FVFPG G W
Sbjct 3045 SRSVFEHRSVVLAGDSAELSAGLDALAADGVSPVLVSGVASVGGG-RSVFVFPGAGVKWA 3103
Query 110 GMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVH 169
GM + E + + C AAFA V+ L ++ ER+ ++ A F
Sbjct 3104 GMALGLWAESAVFAESMARCEAAFAGL-VEWRLADVLGDGAALEREDV----VQPASFAV 3158
Query 170 AVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAV 229
V+LA +WRS GV+PD VGHS GE+AAA +AG ++L D VV RA V + +
Sbjct 3159 MVSLAALWRSLGVVPDAVVGHSQGEIAAAVVAGGLSLEDGARVVVLRARVAEEVLSGGGI 3218
Query 230 AALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITV 289
A++ + + +A GG L ++VVNA S+ V+GE + V + G AR +
Sbjct 3219 ASVRLSRAEVEERLAGGGGGLSVAVVNAPSSTVVAGELGELDRFVAACEAEGVRARRLEF 3278
Query 290 GFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVR 349
G+ H+ +E +R+ L E L D + + F +YW+ NLR VR
Sbjct 3279 GYASHSRFVEPVRERLLEGLADVRPVRGRIPFYSTVEAGEFDTAGLDAEYWFGNLRRPVR 3338
Query 350 FDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE 403
F VE + G R F+E AHP L A+ + E A VGS RR E
Sbjct 3339 FQETVERLLADGFRVFVECGAHPVLTGAVQETAETAGR----EVCAVGSLRRDE 3388
Score = 166 bits (419), Expect = 3e-38, Method: Compositional matrix adjust.
Identities = 121/354 (35%), Positives = 172/354 (49%), Gaps = 12/354 (3%)
Query 52 TRRVRRHRAVLRAADRLELAEGLRALAAGREHPLIAR--SSLGSAPRQAFVFPGQGGHWP 109
+R V HR+V+ A D EL+ GL ALAA P++ +S+G R FVFPG G W
Sbjct 533 SRSVFEHRSVVLAGDSAELSAGLDALAADGVSPVLVSGVASVGGG-RSVFVFPGAGVKWA 591
Query 110 GMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVH 169
GM + E + + C AAFA V+ L ++ ER+ ++ A F
Sbjct 592 GMALGLWAESAVFAESMARCEAAFAGL-VEWRLADVLGDGAALEREDV----VQPASFAV 646
Query 170 AVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAV 229
V+LA +WRS GV+PD VGHS GE+AAA +AG ++L D VV RA V + +
Sbjct 647 MVSLAALWRSLGVVPDAVVGHSQGEIAAAVVAGGLSLEDGARVVVLRARVAEEVLSGGGI 706
Query 230 AALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITV 289
A++ + + +A GG L ++VVNA S+ V+GE + V + G AR +
Sbjct 707 ASVRLSRAEVEERLAGGGGGLSVAVVNAPSSTVVAGELGDLDRFVAACEAEGVRARRLEF 766
Query 290 GFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVR 349
G+ H+ +E +R+ L E L D + + F +YW+ NLR VR
Sbjct 767 GYASHSRFVEPVRERLLEGLADVRPVRGRIPFYSTVEAAEFDTAGLDAEYWFGNLRRPVR 826
Query 350 FDRAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE 403
F VE + G R F+E AHP L A+ + E A VGS RR E
Sbjct 827 FQETVERLLADGFRVFVECGAHPVLTGAVQETAETAGR----EICSVGSLRRDE 876
Score = 75.1 bits (183), Expect = 6e-11, Method: Compositional matrix adjust.
Identities = 103/354 (30%), Positives = 145/354 (41%), Gaps = 73/354 (20%)
Query 669 VVVTGGAGAIGMHYARYLAE-HGARRIVLLSRRAADQATVAMLRK---QHGTVIVSPPCD 724
V+VTG G +G AR+L HG R ++LLSR + A A L + Q G CD
Sbjct 3974 VLVTGATGTLGSLLARHLVTAHGVRHLLLLSRSGREAAGAAELERELRQRGAEFQLLSCD 4033
Query 725 ITDPTQLS-AIAAEYGGVGASLIVHAAGSVISGTAPGVTSAA---VVDNFAAKVLGLAQM 780
TD L A+A + ++H AG + G +T V+ A L L +
Sbjct 4034 ATDRAALKEALATVPAAHPLTAVIHTAGVLDDGVVEALTPERLDRVLRPKADAALNLHDL 4093
Query 781 IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ 840
E PL+ V L S +G+ GG G Y+AAN LD +A AQG V++ WGLW
Sbjct 4094 TEGMPLKAFV---LYSGAVGLLGGAGQANYAAANAFLDGLAQHRHAQGLPAVSLAWGLWS 4150
Query 841 APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQML-L 899
A G D + R+ERSG+ + +Q + + L A DA +L ++ L
Sbjct 4151 ATSTFTDHLGEVD---LRRMERSGITPLTDEQGL-----DLFDRALGAAVDAPQLCVMGL 4202
Query 900 DSRQFERY---EGPTD----------------------------------------PNLT 916
D+ R GPT LT
Sbjct 4203 DTAALRRQAAEHGPTSMPPLLRTLAAPPVRRGAGRSGRGGRAASATDAPSRAQALRERLT 4262
Query 917 IVDAV----------RTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL 960
+DA + QLA VLG V+ S ++G+DS+ A++LRNRL
Sbjct 4263 GLDAAARRDELLVLSQAQLADVLGFADKTAVDPVRSFREIGLDSLTAVELRNRL 4316
>gi|10179852|gb|AAG13917.1|AF263245_13 megalomicin 6-deoxyerythronolide B synthase 1 [Micromonospora
megalomicea subsp. nigra]
Length=3546
Score = 246 bits (628), Expect = 2e-62, Method: Compositional matrix adjust.
Identities = 318/1011 (32%), Positives = 434/1011 (43%), Gaps = 116/1011 (11%)
Query 16 SAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLR 75
SA E + AR +AD+LE P +T+V L + R+ RAVL AADR + E LR
Sbjct 2485 SAKTETALHAQARRLADHLETHPDVPMTDVVWTLTQARQRFDRRAVLLAADRTQAVERLR 2544
Query 76 ALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAA 135
LA G + S + S FVFPGQGG W GM A +P + + C A ++
Sbjct 2545 GLAGGEPGTGVV-SGVASGGGVVFVFPGQGGQWVGM-ARGLLSVPVFVESVVECDAVVSS 2602
Query 136 AGVDSPLPYLIAPPGTDERQAFCEIEI-EGAQFVHAVALAEVWRSCGVLPDLTVGHSLGE 194
S L L G + +++ + FV V+LA +WR CGV+P VGHS GE
Sbjct 2603 VVGFSVLGVLEGRSGA---PSLDRVDVVQPVLFVVMVSLARLWRWCGVVPAAVVGHSQGE 2659
Query 195 VAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGW---LE 251
+AAA +AG +++ D VVA RA + L G +A++ G D L+ +G W LE
Sbjct 2660 IAAAVVAGVLSVGDGARVVALRARALRALAGHGGMASVRRGRDDVQKLL-DSGPWTGKLE 2718
Query 252 LSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPD 311
++ VN V VSG+ +AV +V+ G AR I V + H++ +ESLR+EL L
Sbjct 2719 IAAVNGPDAVVVSGDPRAVTELVEHCDGIGVRARTIPVDYASHSAQVESLREELLSVLAG 2778
Query 312 SEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAH 371
E A V F TG V DYWY NLRH VRF AVE+ F+E+S H
Sbjct 2779 IEGRPATVPFYSTLTGGFVDGTELDADYWYRNLRHPVRFHAAVEALAARDLTTFVEVSPH 2838
Query 372 PALLFAIGQNCEGAANLPDGPAVLVGSARRG----ERFVDALSANIVSAAVADPGYPWGD 427
P L A+G+ + AV VG+ R ERF+ +L+ V D W
Sbjct 2839 PVLSMAVGETLADVES-----AVTVGTLERDTDDVERFLTSLAEAHVHGVPVD----WAA 2889
Query 428 -LGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
LG L VDL P P + W HP+ G V W V T A
Sbjct 2890 VLGSGTL---VDL---PTYPFQGRRFWLHPD-----RGPRDDVADWFHRVDWTATATD-- 2936
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPD----TELSAAR---DAELILVIAPDFE----HTD 535
G+ R + L + + D E+ AA AE ++ + +D
Sbjct 2937 -------GSARLDGRWLVVVPEGYTDDGWVVEVRAALAAGGAEPVVTTVEEVTDRVGDSD 2989
Query 536 AVRAAGALADLVGAGLLDYPMHIGARCQSVCL--VTVGAEQVDAADAVPSAGQAALAAMH 593
AV + LAD A L + A+ + L VTVGA V A V QA + +
Sbjct 2990 AVVSMLGLADDGAAETLALLRRLDAQASTTPLWVVTVGA--VAPAGPVQRPEQATVWGLA 3047
Query 594 RSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADA 653
E + LDLP DP L ++ A+ + A+R + R +
Sbjct 3048 LVASLERGHRWTGLLDLPQ-TPDPQLRPRLVEALAGAEDQVAVRAD----AVHARRIVPT 3102
Query 654 PAVPN--WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLR 711
P ++ G ++VTGG +G AR+LAE GA + L+SRR A V +
Sbjct 3103 PVTGAGPYTAPGGT---ILVTGGTAGLGAVTARWLAERGAEHLALVSRRGPGTAGVDEVV 3159
Query 712 KQ---HGTVIVSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAV 766
+ G + CD+ D + A+ E G + +VHAAG + A +
Sbjct 3160 RDLTGLGVRVSVHSCDVGDRESVGALVQELTAAGDVVRGVVHAAGLPQQVPLTDMDPADL 3219
Query 767 VDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRA 826
D A KV G + +L P LL SS GVWG AY+A N LD A R
Sbjct 3220 ADVVAVKVDGAVHLADLCPEAELF--LLFSSGAGVWGSARQGAYAAGNAFLDAFARHRRD 3277
Query 827 QGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFT---- 882
+G +V WGLW A G +AV+ R ER G+R M+ +A+EA T
Sbjct 3278 RGLPATSVAWGLWAAGG----MTGDQEAVSFLR-ER-GVRPMSVPRALEALERVLTAGET 3331
Query 883 ------VDPLVFAAD--AARLQMLLD------SRQFERYEGPTDPNL------------- 915
VD FA +AR + LL + ER E P + L
Sbjct 3332 AVVVADVDWAAFAESYTSARPRPLLHRLVTPAAAVGERDE-PREQTLRDRLAALPRAERS 3390
Query 916 -TIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
+V VR AAVLG A V DLG DS+ A+ RNRL G
Sbjct 3391 AELVRLVRRDAAAVLG-SDAKAVPATTPFKDLGFDSLAAVRFRNRLAAHTG 3440
Score = 233 bits (594), Expect = 2e-58, Method: Compositional matrix adjust.
Identities = 298/1043 (29%), Positives = 421/1043 (41%), Gaps = 131/1043 (12%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
+LSA E + A +A +L P + +VA L R +R+ AD
Sbjct 1000 VLSASTGEALRARAARLAGHLREHPDQDLDDVAYSLATGRAALAYRSGFVPADASTALRI 1059
Query 74 LRALAAGREHPLIARSSLGSAP-RQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA 132
L LAAG + + AP R FVFPGQG W GM P + + CA A
Sbjct 1060 LDELAAGGSGDAV--TGTARAPQRVVFVFPGQGWQWAGMAVDLLDGDPVFASVLRECADA 1117
Query 133 FAAAGVDSPLPYLIAPPGT---DERQAFCEIEI-EGAQFVHAVALAEVWRSCGVLPDLTV 188
+P+L A D + +++ + F V+LA WR+ GV P +
Sbjct 1118 LEPYLDFEIVPFLRAEAQRRTPDHTLSTDRVDVVQPVLFAVMVSLAARWRAYGVEPAAVI 1177
Query 189 GHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGG 248
GHS GE+AAA +AG+++L DA VA R+ V+ +PG A+A++ + +A I G
Sbjct 1178 GHSQGEIAAACVAGALSLDDAARAVALRSRVIATMPGNGAMASIAASVDEVAARI---DG 1234
Query 249 WLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQ 308
+E++ VN V VSG+R + +V + G A+ + V + H+S +E++RD L +
Sbjct 1235 RVEIAAVNGPRAVVVSGDRDDLDRLVASCTVEGVRAKRLPVDYASHSSHVEAVRDALHAE 1294
Query 309 LPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEI 368
L + + V F TG V P YW+ NLRH VRF AV S G F+E+
Sbjct 1295 LGEFRPLPGFVPFYSTVTGRWVEPAELDAGYWFRNLRHRVRFADAVRSLADQGYTTFLEV 1354
Query 369 SAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPGYP 424
SAHP L AI + E G V V S RRG F AL+ V+ D
Sbjct 1355 SAHPVLTTAIEEIGEDRG----GDLVAVHSLRRGAGGPVDFGSALARAFVAGVAVDWESA 1410
Query 425 WGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPL------PPVSGLTIAVERWERMVPS 478
+ G + P P + W P P VS L +E W P
Sbjct 1411 YQGAGARRVP-------LPTYPFQRERFWLEPNPARRVADSDDVSSLRYRIE-WHPTDPG 1462
Query 479 TPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELI-------LVIAPDF 531
P GR LD L A D + AAR A LV+ P
Sbjct 1463 EP--GR------LD-------GTWLLATYPGRADDRVEAARQALESAGARVEDLVVEPRT 1507
Query 532 EHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQ----- 586
D VR A+ + G L + + A S VT ++ +D AV +G+
Sbjct 1508 GRVDLVRRLDAVGPVAGV-LCLFAVAEPAAEHSPLAVTSLSDTLDLTQAVAGSGRECPIW 1566
Query 587 --------------------AALAAMHRSIGFEHPEQTFSHLDLPSW---DLDPVLGVSV 623
AL A+ R + E+P +D+PS +L LG +
Sbjct 1567 VVTENAVAVGPFERLRDPAHGALWALGRVVALENPAVWGGLVDVPSGSVAELSRHLGTT- 1625
Query 624 ITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYA 683
L G GE + +G A A W VL +G H A
Sbjct 1626 ----LSGAGEDQVALRPDGTYARRWCRAGAGGTGRWQPRGTVLVTGGTG----GVGRHVA 1677
Query 684 RYLAEHGARRIVLLSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIAAEYGG 740
R+LA G +VL SRR D V L + GT CD+TD QL A+ A
Sbjct 1678 RWLARQGTPCLVLASRRGPDADGVEELLTELADLGTRATVTACDVTDREQLRALLATVDD 1737
Query 741 VGA-SLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVM 799
S + H A ++ GT +T + AKVLG + EL +L SS
Sbjct 1738 EHPLSAVFHVAATLDDGTVETLTGDRIERANRAKVLGARNLHELTRDADLDAFVLFSSST 1797
Query 800 GVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIAR 859
+G G+ Y N LD +A Q R++G +V WG W G+A+ R
Sbjct 1798 AAFGAPGLGGYVPGNAYLDGLAQQRRSEGLPATSVAWGTWA-------GSGMAEGPVADR 1850
Query 860 VERSGLRQMAPQQAIEA---SLHEFTVDPLV---------FAADAARLQMLLDSRQFERY 907
R G+ +M P QA+E +L + V P+V A A R L D+ R
Sbjct 1851 FRRHGVMEMHPDQAVEGLRVALVQGEVAPIVVDIRWDRFLLAYTAQRPTRLFDTLDEARR 1910
Query 908 EGP----------------TDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSM 951
P + ++D VRT AAVLG A +V + + +LGVDS+
Sbjct 1911 AAPGPDAGPGVAALAGLPVGEREKAVLDLVRTHAAAVLGHASAEQVPVDRAFAELGVDSL 1970
Query 952 LALDLRNRLKRSIGATVSLATLM 974
AL+LRNRL + G ++ T+
Sbjct 1971 SALELRNRLTTATGVRLATTTVF 1993
Score = 121 bits (303), Expect = 7e-25, Method: Compositional matrix adjust.
Identities = 116/412 (29%), Positives = 184/412 (45%), Gaps = 15/412 (3%)
Query 15 LSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRR--HRAVLRAADRLELAE 72
L H E + AR + YLE V V L + R + HRAV+ A+ EL
Sbjct 24 LCGHNEPELRARARQLHAYLEGISEDDVVAVGAALARETRAQDGPHRAVVVASSVTELTA 83
Query 73 GLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA 132
L ALA GR HP + R FV PGQG WPGM E P + A C A
Sbjct 84 ALAALAQGRPHPSVVRGVARPTAPVVFVLPGQGAQWPGMATRLLAESPVFAAAMRACERA 143
Query 133 FAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSL 192
F D L ++ P E E+ ++ A F +LA +WRS GV PD +GHS+
Sbjct 144 FDEV-TDWSLTEVLDSP---EHLRRVEV-VQPALFAVQTSLAALWRSFGVRPDAVLGHSI 198
Query 193 GEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLEL 252
GE+AAA + G++ + A A + + L GR +AA+ + + +A + +
Sbjct 199 GELAAAEVCGAVDVEAAARAAALWSREMVPLVGRGDMAAVALSPAELAARVERWDDDVVP 258
Query 253 SVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDS 312
+ VN +V ++G + +A V + + G A+ + V H++ ++++ + + L
Sbjct 259 AGVNGPRSVLLTGAPEPIARRVAELAAQGVRAQVVNVSMAAHSAQVDAVAEGMRSALTWF 318
Query 313 EFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHP 372
++ V + G TG + D+W + R VRFD A + + FIE S HP
Sbjct 319 APGDSDVPYYAGLTGGRLDTRELGADHWPRSFRLPVRFDEATRAVLELQPGTFIESSPHP 378
Query 373 ALLFAIGQNCEGAANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVAD 420
L ++ Q + + PA +V + +R + RF+ A++ D
Sbjct 379 VLAASLQQTLDEVGS----PAAIVPTLQRDQGGLRRFLLAVAQAYTGGVTVD 426
>gi|345012879|ref|YP_004815233.1| beta-ketoacyl synthase [Streptomyces violaceusniger Tu 4113]
gi|344039228|gb|AEM84953.1| Beta-ketoacyl synthase [Streptomyces violaceusniger Tu 4113]
Length=5676
Score = 244 bits (623), Expect = 6e-62, Method: Compositional matrix adjust.
Identities = 305/1039 (30%), Positives = 425/1039 (41%), Gaps = 129/1039 (12%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
VA +LS E + A + +L R P T EV L TR HRAV+ AD EL
Sbjct 1461 VAWVLSGQGEAGLRAQAERLRAFLARGPRPTPAEVGWSLASTRTTLSHRAVVVGADCDEL 1520
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
G+ A+A G P + R + G++ FVFPGQG W GM + CA
Sbjct 1521 LRGVDAVAEGIPAPGVVRGT-GASGDVVFVFPGQGSQWVGMALELLESSSVFAGRMAECA 1579
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGH 190
A VD L ++A DER ++ + V+LAE+WRS GV+P VGH
Sbjct 1580 DVLAPL-VDWSLFDVLA----DERALGRVDVVQPVLWAVMVSLAELWRSFGVVPSAVVGH 1634
Query 191 SLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWL 250
S GE+AAA +AG ++L D VV R+ + L GR + ++ + A L G L
Sbjct 1635 SQGEIAAACVAGGLSLVDGARVVVLRSKALLALSGRGGMVSVPV---SADRLRDRPG--L 1689
Query 251 ELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLP 310
++ VN ++ VSG + ++D V + A+ I V + H+ +E +R+EL E L
Sbjct 1690 SVAAVNGPASTVVSGADE----VLDAVLAEFPEAKRIPVDYASHSVQVEEIREELAEALA 1745
Query 311 DSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISA 370
E V F TG ++ YWY NLR TV F VE+ IR G F+E S
Sbjct 1746 GVEPRGGQVPFYSTVTGRLMDTAELDAGYWYRNLRETVEFQGTVETLIRQGHTVFVEASP 1805
Query 371 HPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWGDLGG 430
HP L I + V+VGS RR + + L +++ V W
Sbjct 1806 HPVLTIGIQDTADATDTDTAIDTVVVGSLRRDDGTIQRLLSHLAELHVRGVRIDW----- 1860
Query 431 DPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVER-WERMVPSTPVAG------ 483
PL V P + W +G + E W + P+ G
Sbjct 1861 RPLLAGVSPVELPTYAFQRERFWLG-------AGTAESAESAWRYRIAWRPLPGMDTPTL 1913
Query 484 RHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGAL 543
R L V+ G RA+A + A E AR L + D E G L
Sbjct 1914 RGTWLVVVPEGDERAMAGSRALA-------EQGGAR--VRTLQVPYDAERQGLT---GLL 1961
Query 544 ADLVG----AGLLDY--------PMH----IGARCQSVCLVTVGAEQVDA---------- 577
D+VG +G++ + P H +G L + A +V+A
Sbjct 1962 TDVVGSDDISGVVSFLALDERPHPTHAALSLGMAHTVELLCALTAAEVEAPLWCVTRSAV 2021
Query 578 ----ADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPS-WDLDPVLGVSVITAVLRGFG 632
D+ P+ QAA+ R G E +DLP+ WD + + A G
Sbjct 2022 AALPGDSEPNPAQAAVWGFGRVAGLERSGHWGGLIDLPTQWDAQVLRRFVAVLAETVGED 2081
Query 633 ETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGAR 692
+ A+R S E PA W VL +TGG GA+G H AR+LA+ GA
Sbjct 2082 QVAVRPSATLGRRLEPAATTGPA-DAWRPHGTVL----ITGGTGALGAHVARWLAQAGAE 2136
Query 693 RIVLLSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHA 749
+VLL RR A L + G + + CD+TD L+ + A + A +VH
Sbjct 2137 HLVLLGRRGPQAPGAAALEDELTALGIRVTTTACDVTDRAALAEVLASVPDLTA--VVHL 2194
Query 750 AGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVA 809
AG+V G + G F AKV G + EL +L SS VWGG G
Sbjct 2195 AGTVRFGGSIGAALDEYAAVFDAKVTGALHLDELLDHASLEAFVLFSSAAAVWGGAGQAG 2254
Query 810 YSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMA 869
Y+AAN LLD +A + RA+G ++ WG W A E R+ R GLR M
Sbjct 2255 YAAANALLDGLAQRRRARGLPATSIGWGTWGGSLAPEDEE---------RLNRIGLRPMR 2305
Query 870 PQQAIEASLHEFTVD-PLVFAAD-----------AARLQMLLDSR-QFERYEG------- 909
P+ A+ A H D P AD A R LL + + G
Sbjct 2306 PESAVAALRHVVGSDEPCPVIADVGWETFGPAFMAGRPSPLLSELPKLRKNSGAPAVAGD 2365
Query 910 ------------PTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLR 957
D + +VD VR Q A +LG ++ LG DS+ A++LR
Sbjct 2366 RAGLRRRLAGVPAADQDRMLVDLVREQAAELLGHRHPAAIDPTVPFRQLGFDSLTAVELR 2425
Query 958 NRLKRSIGATVSLATLMGD 976
RL S G + ATL+ D
Sbjct 2426 TRLNTSTGLRLP-ATLLFD 2443
Score = 130 bits (328), Expect = 9e-28, Method: Compositional matrix adjust.
Identities = 115/389 (30%), Positives = 170/389 (44%), Gaps = 28/389 (7%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
+LS +E + + +++ PA + +V L TR + +R V+ D L G
Sbjct 2924 VLSGASEAGLRAQIEQLRTFVDDNPALDLADVGWSLASTRALLPYRTVVVGTDLAALRRG 2983
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
L A+ ++G+ FVFPGQG W GM + CA
Sbjct 2984 LDAVEV--------TGAVGADRGVVFVFPGQGSQWVGMALELAESSAVFAGRLGECADVL 3035
Query 134 AAAGVDSPLPYLIAPPGTDERQAFCEIEI-EGAQFVHAVALAEVWRSCGVLPDLTVGHSL 192
A PL + A +++ + + V+LAE+WRS GV+P VGHS
Sbjct 3036 A------PLVEWSLWDVLSDEAALGRVDVVQPVLWAVMVSLAELWRSFGVVPSAVVGHSQ 3089
Query 193 GEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLEL 252
GE+AAA +AG ++L D VV R+ + L GR + ++ + A L G L +
Sbjct 3090 GEIAAACVAGGLSLEDGARVVVLRSKALLALSGRGGMVSVPV---SADRLRDRPG--LSV 3144
Query 253 SVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDS 312
+ VN ++ VSG ++D V + A+ I V + H+ +E +R+EL E L
Sbjct 3145 AAVNGPASTVVSG----AVDVLDAVLAEFPDAKRIPVDYASHSVQVEEIREELAEALAGV 3200
Query 313 EFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHP 372
E V F TG ++ YWY NLR TV F VE + G F+E S HP
Sbjct 3201 EPCSGRVPFYSAVTGRLMDTTELDARYWYRNLRETVEFQSTVEGLLELGHTVFVEASPHP 3260
Query 373 ALLFAIGQNCEGAANLPDGPAVLVGSARR 401
L I + A+ D VL GS RR
Sbjct 3261 VLTIGI----QDTADAVDTDIVLTGSLRR 3285
Score = 114 bits (285), Expect = 1e-22, Method: Compositional matrix adjust.
Identities = 116/398 (30%), Positives = 181/398 (46%), Gaps = 25/398 (6%)
Query 586 QAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGE--TALRGSVNGY 643
QA + + R IG EHP++ +DLP +D +G + + G GE A+R +
Sbjct 5185 QAGVWGLGRVIGLEHPDRWGGLIDLPP-VVDEGVGSWLCRVLSGGTGEDQVAVRAAGAWG 5243
Query 644 TLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD 703
R A W L VTGG GA+G H AR+LA G +RIVL SRR A+
Sbjct 5244 ARLTRLAPAADTSAEWRGRGAAL----VTGGTGALGGHVARWLAGAGVQRIVLASRRGAE 5299
Query 704 QATVAML---RKQHGTVIVSPPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPG 760
VA L ++ G V+ CD+ D +++A+ A G ++VH AG + G
Sbjct 5300 APGVAELVAGLEELGAVVSVVGCDVADRGEVAALVA--GIADLRVVVHTAGVLDDGVLES 5357
Query 761 VTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVM 820
+TS + + KV G + EL R +L SS G G G +Y+AAN +LD +
Sbjct 5358 LTSERIREVMRVKVAGARYLDELTRGRDLDAFVLFSSAAGTMGNAGQGSYAAANAVLDGL 5417
Query 821 AAQLRAQGRHCVAVKWGLWQAPKAGEPAR---GIADAVTIARVERSGLRQMAPQQAIEAS 877
A + RA+G ++ WG W G R G+ + IA +++S + +
Sbjct 5418 AQRRRAEGLVATSLAWGAWADSGMGAAQRQLPGMPPDLAIAALQQSLVADETTMMIADVE 5477
Query 878 LHEFTV-------DPLVFAADAARLQMLLDSRQF-ERYEGPT--DPNLTIVDAVRTQLAA 927
F PL+ + +F R G + + + +++ VRT +A
Sbjct 5478 WSSFGSRFTAVRPSPLLSELLTIATPPMEPVEEFATRLRGMSRIERDRAVLELVRTHVAV 5537
Query 928 VLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
VLG + V+ + ++G DS+ A++LRNRL + G
Sbjct 5538 VLGHAKPASVDPSRTFQEVGFDSLTAVELRNRLATATG 5575
Score = 103 bits (256), Expect = 2e-19, Method: Compositional matrix adjust.
Identities = 119/407 (30%), Positives = 176/407 (44%), Gaps = 25/407 (6%)
Query 27 ARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEGLRALAAGREHPLI 86
AR + YLER P +T++A L R HRAVL A + A GL LA G P +
Sbjct 466 ARRLRPYLERSP--NLTDLAFSLATIRTTFEHRAVLIAGAATDAAPGLDTLAEGGTAPGL 523
Query 87 ARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLI 146
+ A R AF F GQG GMG P + A D A A +D PL +I
Sbjct 524 V-TGTARAGRLAFAFAGQGSQRLGMGRELSAAFPVFADALDAVCTALDAH-LDRPLRDVI 581
Query 147 APPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITL 206
G D + + F VAL + G++PD+ +GHSLGEV+AA++AG ++L
Sbjct 582 H--GDDAELLDQTVYAQAGLFAVEVALFRLLEDFGLVPDVLIGHSLGEVSAAHVAGVLSL 639
Query 207 SDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIAT-----TGGWLELSVVNASSTV 261
+DA A VAAR ++ + A+ L E + + + T + ++ VN +
Sbjct 640 ADAAAFVAARGRLMQAVTEPGAMVLLEASEDEVTRTLMTGEASDDSARICVAAVNGPAAT 699
Query 262 AVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQF 321
+SG+ +AV + G + + H+ L+ + DEL + +
Sbjct 700 VISGDERAVLHLATEWSHRGRRTKRLRTSHAFHSPHLDPVLDELRHIAESLTYRPPRIPL 759
Query 322 IGGTTGD-VVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQ 380
I TG A +YW ++R TVRF + + G +E+ AL + +
Sbjct 760 ISNVTGSRATAEELCSPEYWVRHVRRTVRFLDGIRALEGEGVTTIVELGPDKALT-TLAR 818
Query 381 NCEGAANLPDGPAVLVGSARRGER----FVDALSANIVSAA--VADP 421
+C P LVG+ RR V AL+ VS A V DP
Sbjct 819 DCL------TRPGTLVGTLRRDRSEPLALVTALAELYVSGAEVVWDP 859
Score = 72.0 bits (175), Expect = 6e-10, Method: Compositional matrix adjust.
Identities = 89/326 (28%), Positives = 134/326 (42%), Gaps = 56/326 (17%)
Query 683 ARYLAE-HGARRIVLLSRRAADQATVAMLRKQH---GTVIVSPPCDITDPTQLSAIAAEY 738
AR+L +G +VL+ RR V L + G + CD+ D A+A
Sbjct 3800 ARHLVSVYGVGEVVLVGRRGWGAPGVGGLVGELEGLGARVRVVACDVGD---RGAVAELV 3856
Query 739 GGV-GASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSS 797
G V G S++VHAAG V G + +V K LG + EL +L SS
Sbjct 3857 GSVEGLSVVVHAAGVVDDGVVGSLDGGRLVGVLGPKALGAWYLHELTCGLDLSAFVLFSS 3916
Query 798 VMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTI 857
GV G G +Y+AAN LD +AA RAQG V++ WG W+ + E +A+ V +
Sbjct 3917 AAGVLGNAGQGSYAAANGFLDALAAHRRAQGLPGVSIAWGFWE--ERSELTIDLAE-VQL 3973
Query 858 ARVERS---------------------------------GLRQMAPQQAIEASLHEFTVD 884
+R+ RS LR+ A + + L
Sbjct 3974 SRISRSVGTSISSEQGLALFDAALVADEAMVLATPLNMPALREQAAAGTLPSILSGLVTA 4033
Query 885 PLVFAAD-----AARLQMLLDSRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNL 939
P+ AA A L + + ER +V V+ +A VLG A ++
Sbjct 4034 PVRRAAGTGGTPAGLRHQLAGATEAEREH-------RVVGLVQEHVAGVLGHVSAESIDT 4086
Query 940 QESLFDLGVDSMLALDLRNRLKRSIG 965
+ ++G DS+ A++LRNR+ + G
Sbjct 4087 SRTFQEIGFDSLTAVELRNRISAATG 4112
>gi|59723044|gb|AAU93805.2| polyketide synthase modules 5 and 6 [Aeromicrobium erythreum]
Length=3195
Score = 244 bits (622), Expect = 7e-62, Method: Compositional matrix adjust.
Identities = 318/1014 (32%), Positives = 428/1014 (43%), Gaps = 104/1014 (10%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V ++LSA + + AR + D V VA L R HRAV+ A D
Sbjct 476 VPLMLSARTPQALRAQARRLLDADVLAADAPVVPVAASLLHRRSRLEHRAVVVADDAGSA 535
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
L LA G+ + R AFVFPGQG W GMGA + C
Sbjct 536 RVALGRLADGQPSRDVLLGRGRDRRRPAFVFPGQGAQWVGMGADLLEHSTVFAEVMRECD 595
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGH 190
A A S L L + D ++ A F V+LAEVWR GV P VGH
Sbjct 596 RALAGHLDVSVLETLRSGSPLDRVDL-----VQPALFAVMVSLAEVWRDSGVQPSAVVGH 650
Query 191 SLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWL 250
S GE+AAA++AG++ L A VVA R+ V+ + GR + +L DAS IA G L
Sbjct 651 SQGEIAAAHVAGALDLETAARVVALRSRVLRGIAGRGGMVSLATTPDDASRRIAPFGDAL 710
Query 251 ELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLP 310
++ VN+ V V+G+ A+ ++ + G AR I V + HT+ +ESLRD++ +L
Sbjct 711 AVASVNSPRAVVVAGDPSALDDLLAQCEADGLRARRIPVDYASHTAHVESLRDDVLRELR 770
Query 311 DSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISA 370
V TG + T DYW+ NLR VRF A S + G A +E+S
Sbjct 771 GVGATTGRVPLHSSLTGAPIDTSTMDADYWFRNLRGQVRFAEAARSLLAEGTDALVEVSP 830
Query 371 HPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWGDLGG 430
HP L A+ Q E A D A ++G+ RRGE L + A VA W
Sbjct 831 HPVLTMALEQVVEDA----DADAAVLGTLRRGEGGAPDLVRALAEAHVAGLPVDW----S 882
Query 431 DPLDGDVDLSGFPNAPMRAVPMWAHPEPLP------PVSGLTIAVERWERM-VPSTPVAG 483
L + P P + W PL P V+ WER V PVAG
Sbjct 883 RELPREAATVELPTYPFQHERFWLE-TPLAGARTGGPADDWRYTVQ-WERTEVADVPVAG 940
Query 484 RHRHLAVLDLGAH------RALAQTLCAAIDSHP-DTELSAARDA-----ELILVIAP-D 530
R L D AH RA+ Q P D E S R L +V P D
Sbjct 941 RV-LLVASDSAAHEVDAVQRAVEQRGGLVEVVRPDDVEASWGRSGVDGSPTLGVVALPHD 999
Query 531 FEHTDAVRAAGALADLV--GAGLLD-YPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQA 587
+ D + A AL LV +G D P+ + R S G VD A Q+
Sbjct 1000 GDERDPLAATEALGALVRSWSGAQDPAPLWVVTRRAS----DAGGSTVDPA-------QS 1048
Query 588 ALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFE 647
A+A + R +G EHP+ H+D+ D D V+ A A+RG+
Sbjct 1049 AVAGLARVVGLEHPQGWGGHVDVDDLDDDAAGVVAAAVAAAGPEDVLAVRGT---DVWAG 1105
Query 648 RTLAD-APAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQAT 706
R AD P P SG V+VTGG GA+G H AR+LA GA +VLL R
Sbjct 1106 RLTADPVPQEPRPWTPSGT---VLVTGGLGAVGRHVARWLARSGAEHLVLLGRGGERGEA 1162
Query 707 VAMLRKQHGTVIVSPP---CDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGV 761
A LR + G + V CD+ D L+A+ A G ++ + HAAG+ + +
Sbjct 1163 AAELRAELGALGVGVSVHACDVADHDALAAVVAAERAEGRTVAAVFHAAGTSTTTPVVAL 1222
Query 762 TSAAVVDNFAAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVM 820
A + AAKV G + +L + TL L SS GVWG G+ AY+AAN LD
Sbjct 1223 EPAELRRVAAAKVQGTLNLADLC---DEASTLVLFSSNAGVWGSPGLGAYAAANAFLDGF 1279
Query 821 AAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEA---- 876
A R G +V WGLW AGE G+ + + G+R M P+ AI
Sbjct 1280 ARSRRGTG--VTSVAWGLW----AGETMAGVEGNTYL---KGQGVRAMRPEHAIAGLETA 1330
Query 877 --------SLHEFTVDPLVFAADAARLQMLLD--------------SRQFERYEGPTDPN 914
S+ + +D V AAR + LD + + G T P
Sbjct 1331 LTRGDTCVSVVDLDLDRFVDVFSAARRRPFLDRLAPAAPKAPQAADAPAADLLVGATTPE 1390
Query 915 ---LTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
+ V ++ VLG+ + V+ + DLG DSM A++LRNRL G
Sbjct 1391 ERRRRLEVVVHREVVGVLGLDEHAAVDRHVAFRDLGFDSMTAVELRNRLAEVTG 1444
Score = 189 bits (479), Expect = 3e-45, Method: Compositional matrix adjust.
Identities = 302/1004 (31%), Positives = 415/1004 (42%), Gaps = 109/1004 (10%)
Query 6 LPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAA 65
L G V ++LSA + A + D L A T+ EVA L R + RAVL
Sbjct 1952 LAGGVVPLVLSARTPRALARQAARLRDALAGTDALTLPEVAWTLATGRAHLQRRAVLLPR 2011
Query 66 DRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGM--GAVAYRELPTYR 123
D + L LA GR + + +A VFPGQG W GM G + +
Sbjct 2012 DVVHARALLDDLAEGRTSSEVVVADARTA-EPVMVFPGQGAQWVGMASGLLGVEVFASAL 2070
Query 124 TATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVL 183
D V L P D + ++ A F V+LA W S GV
Sbjct 2071 AEVDVALGEVLGFSVREVLEGREGAPSLDRVEV-----VQPALFAVMVSLARWWESVGVR 2125
Query 184 PDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALI 243
P VGHS GE+AAA +AG ++++D VVA RA + L G A+A++ + + A +
Sbjct 2126 PAAVVGHSQGEIAAAVVAGVLSVADGARVVARRALALRALSGGGAMASVALPVERVRAWV 2185
Query 244 ATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRD 303
GG LE++ VNA + V V+G+ AV A+V+ R G R + V + H+ +E +R+
Sbjct 2186 EQVGG-LEVAAVNAPAQVVVAGDVAAVEALVEQGRREGVRVRRLAVDYASHSVHVERVRE 2244
Query 304 ELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGAR 363
L +L + V G V G YWY NLR TVRFD AV +A+ G
Sbjct 2245 ALVGELGVVQGRAGRVPVFSSLRGARVEGPELDGAYWYENLRGTVRFDAAVRAAMDEGHE 2304
Query 364 AFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGY 423
F+E+S HP L A+ + PDG + R E + L+ V D
Sbjct 2305 VFLEVSPHPVLAAAVQETA------PDGLVLGSLHRERDEHLLHELARAHVHGVEVD--- 2355
Query 424 PWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAG 483
W L LD + + P V W PEP G + PS P G
Sbjct 2356 -WTAL----LDRTLP-ARLPTTAFEPVRYWLAPEPADRSVGDRYGIVWRTVAEPSVPDPG 2409
Query 484 RHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAAGAL 543
+L LG A + + + + R L L + D AAG L
Sbjct 2410 ---AATLLTLGEPPADLEKVLQGVGT---------RFVPLDLA-----DPQDVAGAAGVL 2452
Query 544 ADLVGAG-LLDYPMHIGARCQSVCLVTVGAEQVDAA-DAVPSAGQAALAAMHRSIGFEHP 601
+ GA LD A V L V V AA D + A + + R +G E P
Sbjct 2453 SFGGGAAEQLDRVQRFLACDVDVPLWCVTRGAVAAAEDDLVDPDAAMVWGLGRVVGLERP 2512
Query 602 EQTFSHLDLPSW-DLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPN-- 658
E+ LDLP+ D + + A+R G L R +A APA +
Sbjct 2513 ERWGGLLDLPAEVTADDTGALLAALLGDDLEDQVAVR---QGRRLCRRLMA-APADRSRR 2568
Query 659 --WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRA--AD--QATVAMLRK 712
W D L VTGG GA+G H AR+L G R +VLLSRR AD Q V LR
Sbjct 2569 RWWPGDGTAL----VTGGTGALGAHVARFLVAQGVRDLVLLSRRGPHADGAQELVEELRA 2624
Query 713 QHGTVIVSPPCDITDPTQLSAIAAEYGGVG--ASLIVHAAGSVISGTAPGVTSAAVVDN- 769
V CD+ D QL+++ G ++VHAAG AP VD
Sbjct 2625 AGADATVV-ACDVADRGQLTSVLDRLRSEGRRVEVVVHAAG------APDARRLEDVDRP 2677
Query 770 ---FAAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLR 825
+ AKV G + EL PDV + L SS WG G+ AY+A N LD +A + R
Sbjct 2678 EEVWRAKVEGARLLDELL---PDVSSFVLFSSGAATWGSAGLGAYAAGNAFLDGLAQRRR 2734
Query 826 AQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEA---SLHEFT 882
++GR +V G A G + + R G+R M P++A+E +L +
Sbjct 2735 SEGRAGTSV--------AWGAWAGGGMAGADLDGLRRRGIRPMRPERALEGLRRALEQDD 2786
Query 883 VDPLVFAADAARLQMLLDS---RQFERYEGPTDPNLTI------------------VDAV 921
V V D AR + + R P DP L V V
Sbjct 2787 VCVSVADVDWARFAVGFTAARPRPLVADLVPDDPELPTSRTAAPAAQAAPTTAEEAVHLV 2846
Query 922 RTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
R Q+A VLG +A +V + + +LG DS+ A+ LRN L+R+ G
Sbjct 2847 RAQMARVLGHARADDVPADQPIGELGFDSLSAVGLRNELQRATG 2890
>gi|326780641|ref|ZP_08239906.1| Mycocerosate synthase., 6-deoxyerythronolide-B synthase [Streptomyces
cf. griseus XylebKG-1]
gi|326660974|gb|EGE45820.1| Mycocerosate synthase., 6-deoxyerythronolide-B synthase [Streptomyces
griseus XylebKG-1]
Length=5188
Score = 243 bits (621), Expect = 1e-61, Method: Compositional matrix adjust.
Identities = 307/1012 (31%), Positives = 437/1012 (44%), Gaps = 139/1012 (13%)
Query 53 RRVRRHRAVLRAADRLELAEGLRALA-AGREHPLIARSSLGSAPRQAFVFPGQGGHWPGM 111
R RAV+ A+ EL L ALA GR P R + + P FVFPGQGG W GM
Sbjct 4128 RSALEQRAVVLGANVHELLADLDALAETGRPSP---RRT--TDPGVVFVFPGQGGQWIGM 4182
Query 112 GAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEI-EGAQFVHA 170
G P + C A VD L +++ ER+ +++ + +
Sbjct 4183 GRELLPACPVFADRLAECERALDPF-VDWSLREVLS---GGEREWLGRVDVVQPVLWAVM 4238
Query 171 VALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVA 230
V+LAEVWR+ GV PD VGHS GE+AAA +AG +++ D VVA R+ + L G+ A+A
Sbjct 4239 VSLAEVWRAAGVEPDAVVGHSQGEIAAAVVAGRLSVEDGARVVALRSRALLGLSGQGAMA 4298
Query 231 ALGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVG 290
++ + D + + G + ++ VNA V VSG VA + + G AR I V
Sbjct 4299 SVAL---DVAEVEGVLPGSVTVAAVNAPGQVVVSGPPDEVAELCVRLDGQGVRARRIEVD 4355
Query 291 FPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRF 350
+ H + +E++ +EL L + V TG+ V YWY NLR VRF
Sbjct 4356 YASHHAQVEAIEEELRAGLEGLSSRGSEVMMWSTVTGEPVRDEELDASYWYRNLREPVRF 4415
Query 351 DRAVESAIRCGARAFIEISAHPALLFAIGQNC-EGAANLPDGPAVLVGSARRGERFVDAL 409
+ AV +A G F+E+ HP L A+ EG + DG ++ + RR + L
Sbjct 4416 ETAVRAAHDHGRGVFVEVGPHPVLGLALSTVLGEGES---DGEGRVLHTLRRDQSETAQL 4472
Query 410 SANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAV 469
++ A A W DL P A A+P +A + IAV
Sbjct 4473 LTSLGEAWAAGLPVAWRDL-------------LPAAEPVALPTYAFQRQRYWLDAPAIAV 4519
Query 470 ER-----------WERMVPSTPVAGR-----HRHLAVL---DLGAH---RALAQ------ 501
+ W V TP+A + HR +L + AH +AL Q
Sbjct 4520 DAAQPVGASPSDAWRYRVGWTPLAAQQADRLHRRWLLLCHEEADAHEVQQALEQAGAKVD 4579
Query 502 --TLCAAIDSHPDTELSAA----RDAELI--LVIAPDFEHTDAVRAAGALADLVGAGLLD 553
L AA D+ P+ + + R AE I L D H D LA L+ +
Sbjct 4580 VRVLPAAADAAPEIDRAGVAELLRGAEHIAYLPAGLDRSHPDHPGLPVGLAALLTV-VQA 4638
Query 554 YPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPS- 612
GAR + ++T GA P AA+ + R G EHP+ +DLP+
Sbjct 4639 VVEQEGAR---LWVLTRGAVNAPGTGGAPDPAAAAVWGLGRVFGLEHPDHYGGLIDLPAL 4695
Query 613 WDLDPVLGVSVITAVLRGF-GETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVV 671
W P G + A+ + ALR F R L APA P + ++
Sbjct 4696 WQ--PRTGGQLAAALAEPVEDQIALRAD----GTFARRLQHAPAPPRGDQEWKPRGTALI 4749
Query 672 TGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ---HGTVIVSPPCDITDP 728
TGG GA+G H AR+LA +GA RI+L+SR D L ++ GT CDI DP
Sbjct 4750 TGGTGALGAHLARWLARNGAERILLVSRTGPDAPGADDLARELTDQGTPTTVVACDIADP 4809
Query 729 TQLSAIAAEYGGVG---ASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWP 785
Q++A+ GG G + ++HAAG T AA + AKV G ++
Sbjct 4810 QQVAALFD--GGDGHPPVTTVIHAAGVPQRTTLQESDPAAFAELLRAKVTGTHHLLAALD 4867
Query 786 LRPDVRTLLCSSVMGVWGG--HGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPK 843
P +L SS GVWG HG AY+AAN LD +A Q R QGR ++V WGLW
Sbjct 4868 EHPADELVLFSSNSGVWGSGLHG--AYAAANAYLDAVAEQQREQGRRAISVAWGLWGGGG 4925
Query 844 AGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHE-FTVDP-LVFAAD---------- 891
A+ + R G+R MAP A+ A+LHE T+D V AD
Sbjct 4926 M-------AEGDGEEYLSRVGIRPMAPDLAV-AALHEALTLDETFVAVADVDWERFVPTY 4977
Query 892 --AARLQMLLDSRQFERYEGPTD------PN-------------------LTIVDAVRTQ 924
A R ++ D + R G D P+ ++ V+ +
Sbjct 4978 TVARRRPLIEDLPEVRRLAGARDTATADAPDDEAQSLRGRLAGLNADDQYAELLAIVQRE 5037
Query 925 LAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGD 976
A VL + V Q + +LG DS++A+++RNRL+R G + ATL+ D
Sbjct 5038 AAKVLELRDPEAVAEQSAFRELGFDSVMAVEVRNRLRRLSGRQLP-ATLVFD 5088
Score = 149 bits (377), Expect = 2e-33, Method: Compositional matrix adjust.
Identities = 138/429 (33%), Positives = 194/429 (46%), Gaps = 14/429 (3%)
Query 58 HRAVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYR 117
RAV+ AD L GL A+ AG + FVFPGQGG W GMG
Sbjct 2606 QRAVVTGADVEALLSGLDAVGAGELAEGVTTGPATPGSGVVFVFPGQGGQWVGMGRELLD 2665
Query 118 ELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVW 177
P + C A VD L ++ G+DE+ ++ + V+LAEVW
Sbjct 2666 SWPVFADRLAVCERALDPF-VDWSLREVLT--GSDEKWLGRVDVVQPVLWAVMVSLAEVW 2722
Query 178 RSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQ 237
R+ GV PD VGHS GE+AAA +AG +++ D VVA R+ + RL G+ A+A++ +
Sbjct 2723 RAAGVEPDAVVGHSQGEIAAAVVAGRLSVEDGARVVALRSRALLRLSGQGAMASVAL--- 2779
Query 238 DASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSV 297
DA + G + ++ VNA V VSG VA + + G AR I V + H +
Sbjct 2780 DAVEVEGVLPGSVTVAAVNAPGQVVVSGPPDEVAELCVRLDGQGVRARRIEVDYASHHAQ 2839
Query 298 LESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESA 357
+E++ +EL L + V TG+ V YWY NLR VRFD AV +A
Sbjct 2840 VEAIEEELRAGLEGLSSRGSEVTMWSTVTGEPVGDEELDASYWYRNLREPVRFDAAVRAA 2899
Query 358 IRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAA 417
FIE+S HP L A+ ++ DG ++ S RRG+ L ++ A
Sbjct 2900 QAHRHAHFIELSPHPVLALALSTVLADGSD--DGYGRVLHSLRRGQAERAQLLRSLGEAW 2957
Query 418 VADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAH-PEPLPPVSGLTIAVERWERMV 476
A G P G G P+ V+ P + W P P+ V V+ W V
Sbjct 2958 AA--GLPVGWRGLLPV---VEPVALPTYAFQRERYWLDAPPPVAAVGAAGSGVDGWRYRV 3012
Query 477 PSTPVAGRH 485
TP+A +H
Sbjct 3013 GWTPLAVQH 3021
Score = 100 bits (248), Expect = 2e-18, Method: Compositional matrix adjust.
Identities = 86/294 (30%), Positives = 136/294 (47%), Gaps = 24/294 (8%)
Query 96 RQAFVFPGQGGHWPGMGAVAYRELPTYRTATD-TCAAAFAAAGVDSPLPYLIAP------ 148
+ A +F GQG + GMG Y + D CA A D LP + P
Sbjct 561 KSAVLFTGQGSQFAGMGVELYGRFGVFAGVVDEVCAVA------DGLLPEPLRPVLFGEG 614
Query 149 --PGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITL 206
G +R F ++ + + V L V CGV D+ VGHS+GEV+AA +G ++L
Sbjct 615 GRGGLIDRTVFAQVGLVALE----VGLWRVLVECGVRADVLVGHSVGEVSAAVASGVLSL 670
Query 207 SDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLELSVVNASSTVAVSGE 266
+DAV +V R ++ +P + ++ E+ + G + ++ VNA +V ++GE
Sbjct 671 ADAVRLVCVRGRLMEEVPAGGVMVSVAAPEEVVRGRVVGVAG-VWVAAVNAPGSVVLAGE 729
Query 267 RQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTT 326
AV +VD + + G R + VG HT +++ + +E ++ F + + T
Sbjct 730 EGAVRGVVDGLVAEGVRTRWLPVGHAFHTPLMDPVLEEFSREIAGLAFEAPRIPVVSTVT 789
Query 327 GDVVAPGTTFGD--YWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAI 378
G+V G FG YW + R VRF AV A G R + E+ PAL A+
Sbjct 790 GEVA--GADFGSAAYWVEHARRPVRFADAVGVARGLGVRVWAEVGPQPALSAAL 841
Score = 99.4 bits (246), Expect = 3e-18, Method: Compositional matrix adjust.
Identities = 134/440 (31%), Positives = 196/440 (45%), Gaps = 49/440 (11%)
Query 565 VCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPS-WDLDPVLGVSV 623
+ +VT GA V +VP AA+ + R G EH +D+P W G +
Sbjct 3148 LWVVTRGAVSVSGGGSVPDPVLAAVWGLGRVFGLEHAGHYGGLVDVPVVWGAG--TGGLL 3205
Query 624 ITAVLRGFGETALRGSVNGYTLFERTLADAPA-VPNWSLDSGVLDDVVVTGGAGAIGMHY 682
+TA+ + E L +G +F R L APA + + V+VTGG G +G H
Sbjct 3206 VTALAQSV-EDQLAVGADG--VFVRRLRRAPASLSGRGVGWRPGGTVLVTGGTGGLGSHL 3262
Query 683 ARYLAEHGARRIVLLSR---RAADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYG 739
AR+LA GA +VL+SR RA +A GT CDITD TQL+ +
Sbjct 3263 ARWLARSGAEHVVLVSRSGRRAEGAVALAEELAAAGTPTTVRACDITDATQLAEVLGCTD 3322
Query 740 GVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPL-RPDVRTLLCSSV 798
+ ++HAA ++ T + AK G A + +L PDVR +L SS+
Sbjct 3323 HPPITTVIHAAATIELAHLRDATPEHLSTVLDAKCTGAAHLADLLGAHHPDVRLVLFSSI 3382
Query 799 MGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIA 858
G+WG AY+AAN LD + A+ RA + +V WG+W E A G D +
Sbjct 3383 AGIWGSGVHGAYAAANAYLDAL-AESRAATQPITSVAWGIWDT----ELALGRVDPDQMY 3437
Query 859 R-----VER----SGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLL----DSRQFE 905
R ++R L Q+ ++ ++ E V AAR + LL D R E
Sbjct 3438 RQGLPFLDRDRALDALAQVLAEEETVLAIAEVDWPTFVPVFTAARPRPLLSELPDVRALE 3497
Query 906 RYE----GPT----------------DPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFD 945
E PT + + ++D VRT+ A+VLG ++ +L D
Sbjct 3498 SAEQESTAPTASSSALVERLATATEAERDAALLDMVRTEAASVLGHTGLDDIGPHRALRD 3557
Query 946 LGVDSMLALDLRNRLKRSIG 965
+G DS+ A+DLRNRL +G
Sbjct 3558 VGFDSLTAVDLRNRLGAKLG 3577
Score = 55.8 bits (133), Expect = 4e-05, Method: Compositional matrix adjust.
Identities = 65/226 (29%), Positives = 101/226 (45%), Gaps = 39/226 (17%)
Query 793 LLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKA--GEPARG 850
L+ SS+ GV G G Y+AAN LD + RA+G +V WGLW GE R
Sbjct 1863 LVFSSLAGVVGSPGQANYAAANGFLDGLMQWRRARGLVGQSVAWGLWDVTSGMTGELTRS 1922
Query 851 IADAVTIARVERSGLRQMAPQQ--AIEASLHEFTVDPLVFAA--------DAARLQMLL- 899
+AR+ R G+ ++ + A+ + E D L+ AA AA + LL
Sbjct 1923 -----DVARMSRGGVTGLSAAEGTALLGAAREMP-DALMMAARWDWQAWDSAATVPQLLR 1976
Query 900 -----DSRQFERYEGPTDPNL--------------TIVDAVRTQLAAVLGIPQAGEVNLQ 940
S + R GP + + D +R ++A+VLG +V +
Sbjct 1977 GLVRDGSPRNHRGRGPATVDARRRLNRLSRSEALSAVSDEIRGEVASVLGFGSVVDVPVG 2036
Query 941 ESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKL 986
+ ++G DS+ A++LRNRL G +S AT++ D G +A+
Sbjct 2037 LAFREMGFDSLTAVELRNRLGVLFGVRLS-ATVVFDYPSVGALAEF 2081
>gi|59723045|gb|AAU93807.2| polyketide synthase modules 1 and 2 [Aeromicrobium erythreum]
Length=3528
Score = 243 bits (619), Expect = 2e-61, Method: Compositional matrix adjust.
Identities = 305/1057 (29%), Positives = 449/1057 (43%), Gaps = 113/1057 (10%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
+LS +E + A +AD+LE P +VA L R HR L + +AE
Sbjct 954 VLSGASESAVATQAARLADHLEARPDLDPLDVAHALATGRSPLGHRVGLVPSRDDAVAE- 1012
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
LR +A G AR + + R FVFPGQG W GM P + CA A
Sbjct 1013 LRRVADGTSQ--AARGVVEAPLRPVFVFPGQGWQWAGMAVELLDSSPVFARTMRECARAL 1070
Query 134 AAAGVDSPLPYLI-----APPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTV 188
+ +L A PG + ++ F V+LA WR+ GV P V
Sbjct 1071 RPHLDLDVVAFLREEAARATPGGALSTERVD-HVQPVMFAVMVSLAATWRAQGVEPSAVV 1129
Query 189 GHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGG 248
GHS GE+AAA +AG +TL DA +VA R+ + + R A+ ++ + I G
Sbjct 1130 GHSQGEIAAACVAGLLTLEDAARIVARRSVAIAGMTRRGAMVSVAAPVEQVRERI---GD 1186
Query 249 WLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQ 308
L+++ VN+ ++V V+G+ A+ +V + G A + V + H+ ++ + + E
Sbjct 1187 GLDVASVNSPTSVVVAGDADALERLVAECAADGVRATRLPVDYASHSRHVDDVERAVLEG 1246
Query 309 L-PDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIE 367
L P + V + TG V PG YW+ NLR TVRF AVE+ + G AF+E
Sbjct 1247 LSPAPRPLPGAVPMLSTVTGRWVGPGELGPQYWFDNLRSTVRFSDAVETLVESGRTAFVE 1306
Query 368 ISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWGD 427
+SAHP LL + Q E L RR D L+A++ A V
Sbjct 1307 VSAHPILLAPVEQTAEAVGVDVVTVGTL----RRASGGPDELAASLARAFV--------- 1353
Query 428 LGGDPLDGDVDLSG-------FPNAPMRAVPMWAHP---------EPLP---PVSGLTIA 468
GG P+D G P P +W P EP P +S +A
Sbjct 1354 -GGVPVDWQETFRGSGATPVELPTYPFERRRIWWSPPDRRVSVGGEPDPRAYRISWRPVA 1412
Query 469 VERWERMVPSTPVAGRHRHLAVLDLGAHRALA------QTLCAA-------IDSHPDTEL 515
+ R+ + V R H A L G + L+ + LC A + + D L
Sbjct 1413 ADPGARLTGTWWVLHRPDHDAGLLAGVEQELSRRGAQVERLCVAPGGAAHDVATRLDQGL 1472
Query 516 SAARDAELILVIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQV 575
A L+ V AP E T A + A+ DL+ G++ + GA + C VT GA
Sbjct 1473 DVAGVLSLLAVDAP--EDTSAPLDSDAVRDLL--GVVQSVVAAGATTRVWC-VTSGAVAT 1527
Query 576 DAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVL---RGFG 632
+AV + G AL + R +G E+P +DLP+ D V VS + AVL G
Sbjct 1528 GPHEAVRTLGGGALWGLGRVVGLENPAVWGGLVDLPADVGDDV--VSQLGAVLATDDGED 1585
Query 633 ETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGAR 692
+ ALRG+ + R APA W VL VTG G +G H AR+LA GAR
Sbjct 1586 QVALRGTGPWARRWVRVA--APATQQWRPQGTVL----VTGATGGVGRHVARWLAGRGAR 1639
Query 693 RIVLLSRR---AADQATVAMLRKQHGTVIVSPPCDITDPTQLSAIAAEYG-GVGASLIVH 748
R+VLLSRR A D A + ++ G + CD+TD L+A+ + G + + + H
Sbjct 1640 RLVLLSRRGPQAPDAAALVRDLEEAGAEVDLRACDVTDRDALAAVLSYIGDDMPLTSVFH 1699
Query 749 AAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVV 808
AA ++ +T+ + + AKV G + L +L SS +G G+
Sbjct 1700 AAATLDDAVVTELTAERIERSSRAKVQGALHLDALTRAGDLDDFVLFSSFASAFGAPGLG 1759
Query 809 AYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQM 868
Y+ N +LD +A + R G +V WG W G+A+ R R G+ M
Sbjct 1760 GYAPGNAVLDAIAHERRRAGLPATSVSWGTWA-------GGGMAEGPVAERFRRHGVLLM 1812
Query 869 APQQA---IEASLHEFTVDPLVFAADAARL----QMLLDSRQFERYE------------- 908
P A + ++L P+V R L +R F+
Sbjct 1813 DPDAATASLVSALDRADPAPIVMDVQWRRFLAAYTALRPTRLFDELSDAAEPPAHPVRGS 1872
Query 909 ---GPTDPNLT--IVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRS 963
GP P + VR ++A VLG + V++ + LGVDS+ AL+LRN L +
Sbjct 1873 EPAGPGRPQDVGALAALVRDRVATVLGHESSDAVDVDQPFSRLGVDSLSALELRNVLGTA 1932
Query 964 IGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVD 1000
+G + + T L A L A+E + Q V+
Sbjct 1933 LGLRLPTTIVFDHPTTRRLTAHL--AEETGLSEQAVE 1967
Score = 114 bits (284), Expect = 1e-22, Method: Compositional matrix adjust.
Identities = 103/351 (30%), Positives = 154/351 (44%), Gaps = 36/351 (10%)
Query 52 TRRVRRHRAVL---RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQ-----AFVFPG 103
T R HR+V+ AA +L E L A+ AGR H + APR+ AFVFPG
Sbjct 17 TSRTDGHRSVVVLDDAASASDLVEVLDAVVAGRPHARLVEG----APRRDPGMTAFVFPG 72
Query 104 QGGHWPGMGAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIE 163
QG WPGMGA E + A C A PG E E +
Sbjct 73 QGAQWPGMGARLREESSIFDEAMTRCLAVLGEE-----------LPGWSEDALHSEAALR 121
Query 164 GAQFVH------AVALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARA 217
+ V +LA +W++ GV D+ VGHS+GE+AAA +AG+ + D + +
Sbjct 122 AVEVVQPALYAVQTSLAALWQAHGVRADVVVGHSIGELAAARVAGAFSHDDGARGASRWS 181
Query 218 NVVGRLPGRYAVAALGIGEQDASALIATTGGW----LELSVVNASSTVAVSGERQAVAAI 273
+ L G +A++G+ + AL+ W +EL+ VN +V ++G AV
Sbjct 182 RAMMPLVGVGDMASVGLSLDEVLALLER---WQDPDVELAGVNGPGSVLLAGAPDAVRRR 238
Query 274 VDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPG 333
V +++ G A+ I V H+ ++++ +L + F+ V
Sbjct 239 VAELQAEGVRAQVIAVEMAAHSRQVDAVAADLAGAFDGLAPASLALPFVSSVAAGHVDGP 298
Query 334 TTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHPALLFAIGQNCEG 384
G +W R VR+D+AV A+ G R F+E+S HP L Q EG
Sbjct 299 DLVGAHWARCFREPVRYDQAVAVALADGVRTFVEVSPHPVLTAVTRQTIEG 349
Score = 105 bits (261), Expect = 5e-20, Method: Compositional matrix adjust.
Identities = 126/391 (33%), Positives = 180/391 (47%), Gaps = 21/391 (5%)
Query 2 APKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAV 61
AP L V ++LSA + + A+A D L A + + A L R HRAV
Sbjct 2412 APGGLGGDLVPLVLSARTPQALARLAKATVDRLAGDDAPDLADAAWTLATGRARLPHRAV 2471
Query 62 LRAADRLE-------LAEGLRALAAGREHPLIARSSLG-SAPRQAFVFPGQGGHWPGM-- 111
+ ADR +AEGL ++ P +R + G + P VFPGQG W GM
Sbjct 2472 V-TADRASAVTRLGAVAEGLPSVHVATTDP--SRPAAGVTGP--VMVFPGQGAQWVGMAS 2526
Query 112 GAVAYRELPTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAV 171
G + + D V L P D + ++ A F V
Sbjct 2527 GLLGVEVFASALAEVDVALGEVLGFSVREVLEGREGAPSLDRVEV-----VQPALFAVMV 2581
Query 172 ALAEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAA 231
+LA W S GV P VGHS GE+AAA +AG ++++D VVA RA + L G A+A+
Sbjct 2582 SLARWWESVGVRPAAVVGHSQGEIAAAVVAGVLSVADGARVVARRALALRALSGGGAMAS 2641
Query 232 LGIGEQDASALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGF 291
+ + + A + GG LE++ VNA + V V+G+ AV A+V+ R G R + V +
Sbjct 2642 VALPVERVRAWVEQVGG-LEVAAVNAPAQVVVAGDVAAVEALVEQGRREGVRVRRLAVDY 2700
Query 292 PVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFD 351
H+ +E +R+ L +L + V G V G YWY NLR TVRFD
Sbjct 2701 ASHSVHVERVREALVGELGVVQGRAGRVPVFSSLRGARVEGPELDGAYWYENLRGTVRFD 2760
Query 352 RAVESAIRCGARAFIEISAHPALLFAIGQNC 382
AV +A+ G F+E+S HP L A+ +
Sbjct 2761 AAVRAAMDEGHEVFLEVSPHPVLAAAVQETA 2791
Score = 59.7 bits (143), Expect = 3e-06, Method: Compositional matrix adjust.
Identities = 107/347 (31%), Positives = 147/347 (43%), Gaps = 64/347 (18%)
Query 678 IGMHYARYLAEHGARRIVLLSRRAAD----QATVAMLRKQHGTVIVSPPCDITDPTQLSA 733
+G AR+L GAR + LLSRR + VA LR V V CD+TD L A
Sbjct 3086 LGAVTARWLIGRGARSLALLSRRGPGTPGVEQLVAELRDAGAEVTVQA-CDVTDRASLRA 3144
Query 734 IAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRT- 792
+ + V + +VHAAG + A++ K G A + EL PD
Sbjct 3145 ALSVHDDV--TGVVHAAGLPQHQALADMDEASLRRVLDVKATGAALLDEL---VPDAGLF 3199
Query 793 LLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIA 852
LL SS VWG +G AY+A N LD +A + A GR +V WGLW+ +
Sbjct 3200 LLFSSGAAVWGSNGQAAYAAGNAALDALARRRHAAGRAATSVAWGLWETGGMTQ------ 3253
Query 853 DAVTIARVERSGLRQMAPQQAIEASLHEFTV----------DPLVFAAD--AARLQMLLD 900
D + + G+ MA + A+ A V D FAA AAR + LLD
Sbjct 3254 DQAAVDYLRDRGVTPMASEAALSALERVLAVGVPNAVVAHIDWPTFAAAYCAARPRPLLD 3313
Query 901 SRQFERYEGPTD-----------------PNL--------------TIVDAVRTQLAAVL 929
R PT+ P L ++ VR AAVL
Sbjct 3314 ---LLRGGTPTEGAQHEPEPAEETGAEAAPGLGDELAGLPAVERRARLLRLVRVHAAAVL 3370
Query 930 GIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGATVSLATLMGD 976
G + ++S DLG DS+ AL LR+ L+++ G T+S +TL+ D
Sbjct 3371 GHDDPATIRPRDSFKDLGFDSLAALRLRDGLQKASGLTLS-STLVYD 3416
>gi|54778585|gb|AAV39550.1| EryAI (morphed) [synthetic construct]
Length=3554
Score = 242 bits (618), Expect = 2e-61, Method: Compositional matrix adjust.
Identities = 313/1047 (30%), Positives = 436/1047 (42%), Gaps = 106/1047 (10%)
Query 4 KQLP-DGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
+ LP G V V+LSA + A +AD+L P +V+ + + R+ RA +
Sbjct 2468 RMLPATGVVPVVLSARTGAALRAQAGRLADHLAAHPGIAPADVSWTMARARQHFEERAAV 2527
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL--- 119
AAD E LRA+A G P + S S FVFPGQG W GM REL
Sbjct 2528 LAADTAEAVHRLRAVADGAVVPGVVTGS-ASDGGSVFVFPGQGAQWEGMA----RELLPV 2582
Query 120 PTYRTATDTC------AAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVAL 173
P + + C A F+ + V P P + D Q F V+L
Sbjct 2583 PVFAESIAECDAVLSEVAGFSVSEVLEPRPDAPSLERVDVVQPVL--------FAVMVSL 2634
Query 174 AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG 233
A +WR+CG +P +GHS GE+AAA +AG+++L D + VVA R+ V + GR ++ ++
Sbjct 2635 ARLWRACGAVPSAVIGHSQGEIAAAVVAGALSLEDGMRVVARRSRAVRAVAGRGSMLSVR 2694
Query 234 IGEQDASALIATTG--GWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGF 291
G D L+A G LE++ VN V V+G+ QA ++ G AR I V +
Sbjct 2695 GGRSDVEKLLADDSWTGRLEVAAVNGPDAVVVAGDAQAAREFLEYCEGVGIRARAIPVDY 2754
Query 292 PVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFD 351
HT+ +E +RDEL + L A V F TGD + YWY NLRH V F
Sbjct 2755 ASHTAHVEPVRDELVQALAGITPRRAEVPFFSTLTGDFLDGTELDAGYWYRNLRHPVEFH 2814
Query 352 RAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARR----GERFVD 407
AV++ G FIE+S HP L ++ + + A + A ++G+ R +RF+
Sbjct 2815 SAVQALTDQGYATFIEVSPHPVLASSVQETLDDA----ESDAAVLGTLERDAGDADRFLT 2870
Query 408 ALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTI 467
AL+ D W + G G VDL G+P R W P+ P L
Sbjct 2871 ALADAHTRGVAVD----WEAVLGRA--GLVDLPGYPFQGKR---FWLQPDRTTPRDELDG 2921
Query 468 AVER--WERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELIL 525
R W + S P A R R L V+ G + + E R ++
Sbjct 2922 WFYRVDWTEVPRSEPAALRGRWLVVVPEGHEEDGWTVEVRSALAEAGAEPEVTRGVGGLV 2981
Query 526 VIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAG 585
A+ GA+ LV LD A L TV VDA V
Sbjct 2982 GDCAGVVSLLALEGDGAVQTLVLVRELD------AEGIDAPLWTVTFGAVDAGSPVARPD 3035
Query 586 QAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTL 645
QA L + + E + +DLP DP L +TAVL G + +V +
Sbjct 3036 QAKLWGLGQVASLERGPRWTGLVDLPHMP-DPEL-RGRLTAVLAGSEDQV---AVRADAV 3090
Query 646 FERTLADA--PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD 703
R L+ A A +++ G ++VTGG +G AR+LA GA + L+SRR D
Sbjct 3091 RARRLSPAHVTATSEYAVPGGT---ILVTGGTAGLGAEVARWLAGRGAEHLALVSRRGPD 3147
Query 704 QATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIA---AEYGGVGASLIVHAAGSVISGT 757
V L + G + CD++ + + E G V +VHAAG
Sbjct 3148 TEGVGDLTAELTRLGARVSVHACDVSSREPVRELVHGLIEQGDV-VRGVVHAAGLPQQVA 3206
Query 758 APGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLL 817
+ AA + AAK G + EL LL SS GVWG AY+A N L
Sbjct 3207 INDMDEAAFDEVVAAKAGGAVHLDEL--CSDAELFLLFSSGAGVWGSARQGAYAAGNAFL 3264
Query 818 DVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAI--- 874
D A R +G +V WGLW A G +AV+ R ER G+R M +A+
Sbjct 3265 DAFARHRRGRGLPATSVAWGLWAAGG----MTGDEEAVSFLR-ER-GVRAMPVPRALAAL 3318
Query 875 -------EASLHEFTVDPLVFAAD--AARLQMLLD----SRQFERYEGPTDPNL------ 915
E ++ VD FA AAR + LLD + ER P +L
Sbjct 3319 DRVLASGETAVVVTDVDWPAFAESYTAARPRPLLDRIVTTAPSERAGEPETESLRDRLAG 3378
Query 916 --------TIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGAT 967
+V VRT A VLG V +LG DS+ A+ LRN L + G
Sbjct 3379 LPRAERTAELVRLVRTSTATVLGHDDPKAVRATTPFKELGFDSLAAVRLRNLLNAATGLR 3438
Query 968 VSLATLMGDITGDGLVAKLEDADERSH 994
+ +TL+ D VA DA+ S
Sbjct 3439 LP-STLVFDHPNASAVAGFLDAELSSE 3464
Score = 217 bits (553), Expect = 8e-54, Method: Compositional matrix adjust.
Identities = 283/1033 (28%), Positives = 425/1033 (42%), Gaps = 107/1033 (10%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
+LSA + E + A +A +L P ++A L R HRA D
Sbjct 1001 VLSASSAEGLRAQAARLAAHLREHPGQDPRDIAYSLATGRAALPHRAAFAPVDESAALRV 1060
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
L LA G +S R FVFPGQG W GM P + A CA A
Sbjct 1061 LDGLATGNADGAAVGTSRAQQ-RAVFVFPGQGWQWAGMAVDLLDTSPVFAAALRECADAL 1119
Query 134 AAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDLTVG 189
+P+L A E+ A E ++ F V+LA +WR+ GV P +G
Sbjct 1120 EPHLDFEVIPFLRAEAARREQDAALSTERVDVVQPVMFAVMVSLASMWRAHGVEPAAVIG 1179
Query 190 HSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGW 249
HS GE+AAA +AG+++L DA VVA R+ V+ +PG +A++ + A I G
Sbjct 1180 HSQGEIAAACVAGALSLDDAARVVALRSRVIATMPGNKGMASIAAPAGEVRARI---GDR 1236
Query 250 LELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQL 309
+E++ VN +V V+G+ + +V + + A+ + V + H+S +E++RD L +L
Sbjct 1237 VEIAAVNGPRSVVVAGDSDELDRLVASCTTECIRAKRLAVDYASHSSHVETIRDALHAEL 1296
Query 310 PDSEFMEAP--VQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIE 367
+ +F P V F TG P YWY NLR TVRF AV + G R F+E
Sbjct 1297 GE-DFHPLPGFVPFFSTVTGRWTQPDELDAGYWYRNLRRTVRFADAVRALAEQGYRTFLE 1355
Query 368 ISAHPALLFAIGQNCEGA-ANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPG 422
+SAHP L AI + +G+ A+L + S RRG+ F +ALS + D
Sbjct 1356 VSAHPILTAAIEEIGDGSGADLS-----AIHSLRRGDGSLADFGEALSRAFAAGVAVD-- 1408
Query 423 YPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPV- 481
W + L P P + +W P+P+ S V + P
Sbjct 1409 --WESVH---LGTGARRVPLPTYPFQRERVWLQPKPVARRSTEVDEVSALRYRIEWRPTG 1463
Query 482 AGRHRHLAVLDLGAHRA--LAQTLCAAIDSHPDTELSAARDAELIL-VIAPDFEHTDAVR 538
AG L L A A +T AA ++ E + AR EL++ E + +R
Sbjct 1464 AGEPARLDGTWLVAKYAGTADETSTAAREA---LESAGARVRELVVDARCGRDELAERLR 1520
Query 539 AAGALADLVGAGLLDY------PMHIGARCQSVCL---------------VTVGAEQVDA 577
+ G +A ++ +D P+ + + ++ L VT A
Sbjct 1521 SVGEVAGVLSLLAVDEAEPEEAPLALASLADTLSLVQAMVSAELGCPLWTVTESAVATGP 1580
Query 578 ADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALR 637
+ V +A AL + R I E+P +D+P+ + L + V G GE L
Sbjct 1581 FERVRNAAHGALWGVGRVIALENPAVWGGLVDVPAGSVAE-LARHLAAVVSGGAGEDQLA 1639
Query 638 GSVNGYTLFERTLADAPAVPN-WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVL 696
+G A APA + W VL G G I AR+LA GA ++L
Sbjct 1640 LRADGVYGRRWVRAAAPATDDEWKPTGTVLVTGGTGGVGGQI----ARWLARRGAPHLLL 1695
Query 697 LSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIAAEYGGVG----ASLIVHA 749
+SR D L + G CD+TD + + GG+G S + HA
Sbjct 1696 VSRSGPDADGAGELVAELEALGARTTVAACDVTDRESVREL---LGGIGDDVPLSAVFHA 1752
Query 750 AGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVA 809
A ++ GT +T + AKVLG + EL +L SS +G G+
Sbjct 1753 AATLDDGTVDTLTGERIERASRAKVLGARNLHELTRELDLTAFVLFSSFASAFGAPGLGG 1812
Query 810 YSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMA 869
Y+ N LD +A Q R+ G AV WG W G+A+ R R G+ +M
Sbjct 1813 YAPGNAYLDGLAQQRRSDGLPATAVAWGTWA-------GSGMAEGPVADRFRRHGVIEMP 1865
Query 870 PQ---QAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGPTDP------------- 913
P+ +A++ +L V P+V R + +++ R D
Sbjct 1866 PETACRALQNALDRAEVCPIVIDVRWDRFLLAYTAQRPTRLFDEIDDARRAAPQAAAEPR 1925
Query 914 ------------NLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLK 961
+ + VR+ AAVLG A V ++ +LGVDS+ AL+LRNRL
Sbjct 1926 VGALASLPAPEREKALFELVRSHAAAVLGHASAERVPADQAFAELGVDSLSALELRNRLG 1985
Query 962 RSIGATVSLATLM 974
+ G + T+
Sbjct 1986 AATGVRLPTTTVF 1998
Score = 130 bits (328), Expect = 8e-28, Method: Compositional matrix adjust.
Identities = 132/428 (31%), Positives = 194/428 (46%), Gaps = 23/428 (5%)
Query 15 LSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRR--HRAVLRAADRLELAE 72
LS E + AR + +L+RFP V V L + HRAV+ A+ EL +
Sbjct 24 LSGCNESALRARARQLRAHLDRFPDAGVEGVGAALAHDEQADAGPHRAVVVASSTSELLD 83
Query 73 GLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA 132
GL A+A GR H + R + FVFPGQG W GM E + A D CA A
Sbjct 84 GLAAVADGRPHASVVRGVARPSAPVVFVFPGQGAQWAGMAGELLGESRVFAAAMDACARA 143
Query 133 FAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSL 192
F D L ++ P E+ E+ ++ A F +LA +WRS GV PD VGHS+
Sbjct 144 FEPV-TDWTLAQVLDSP---EQSRRVEV-VQPALFAVQTSLAALWRSFGVTPDAVVGHSI 198
Query 193 GEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLEL 252
GE+AAA++ G+ +DA A + + L G +AA+ + + IA + L
Sbjct 199 GELAAAHVCGAAGAADAARAAALWSREMIPLVGNGDMAAVALSADEIEPRIARWDDDVVL 258
Query 253 SVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTS----VLESLRDELCEQ 308
+ VN +V ++G + VA V + + G A+ I V H++ + E +R L
Sbjct 259 AGVNGPRSVLLTGSPEPVARRVQELSAEGVRAQVINVSMAAHSAQVDDIAEGMRSALAWF 318
Query 309 LPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEI 368
P + V F TG V DYW + R VRFD A+ SA+ G F+E
Sbjct 319 APGG----SEVPFYASLTGGAVDTRELVADYWRRSFRLPVRFDEAIRSALEVGPGTFVEA 374
Query 369 SAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPGYP 424
S HP L A+ Q + + A +V + +RG+ RF+ A + D
Sbjct 375 SPHPVLAAALQQTLDAEGS----SAAVVPTLQRGQGGMRRFLLAAAQAFTGGVAVDWTAA 430
Query 425 WGDLGGDP 432
+ D+G +P
Sbjct 431 YDDVGAEP 438
>gi|134097327|ref|YP_001102988.1| EryAI erythromycin polyketide synthase modules 1 and 2 [Saccharopolyspora
erythraea NRRL 2338]
gi|55419415|gb|AAV51820.1| EryAI [Saccharopolyspora erythraea]
gi|133909950|emb|CAM00062.1| EryAI Erythromycin polyketide synthase modules 1 and 2 [Saccharopolyspora
erythraea NRRL 2338]
Length=3545
Score = 241 bits (614), Expect = 6e-61, Method: Compositional matrix adjust.
Identities = 313/1044 (30%), Positives = 437/1044 (42%), Gaps = 108/1044 (10%)
Query 4 KQLP-DGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
+ LP G V V+LSA + A +AD+L P +V+ + + R+ RA +
Sbjct 2468 RMLPATGVVPVVLSARTGAALRAQAGRLADHLAAHPGIAPADVSWTMARARQHFEERAAV 2527
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL--- 119
AAD E LRA+A G P + S S FVFPGQG W GM REL
Sbjct 2528 LAADTAEAVHRLRAVADGAVVPGVVTGS-ASDGGSVFVFPGQGAQWEGMA----RELLPV 2582
Query 120 PTYRTATDTC------AAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVAL 173
P + + C A F+ + V P P + D Q F V+L
Sbjct 2583 PVFAESIAECDAVLSEVAGFSVSEVLEPRPDAPSLERVDVVQPVL--------FAVMVSL 2634
Query 174 AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG 233
A +WR+CG +P +GHS GE+AAA +AG+++L D + VVA R+ V + GR ++ ++
Sbjct 2635 ARLWRACGAVPSAVIGHSQGEIAAAVVAGALSLEDGMRVVARRSRAVRAVAGRGSMLSVR 2694
Query 234 IGEQDASALIA--TTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGF 291
G D L+A + G LE++ VN V V+G+ QA ++ G AR I V +
Sbjct 2695 GGRSDVEKLLADDSWTGRLEVAAVNGPDAVVVAGDAQAAREFLEYCEGVGIRARAIPVDY 2754
Query 292 PVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFD 351
HT+ +E +RDEL + L A V F TGD + YWY NLRH V F
Sbjct 2755 ASHTAHVEPVRDELVQALAGITPRRAEVPFFSTLTGDFLDGTELDAGYWYRNLRHPVEFH 2814
Query 352 RAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARR----GERFVD 407
AV++ G FIE+S HP L ++ + + A + A ++G+ R +RF+
Sbjct 2815 SAVQALTDQGYATFIEVSPHPVLASSVQETLDDA----ESDAAVLGTLERDAGDADRFLT 2870
Query 408 ALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTI 467
AL+ D W + G G VDL G+P R W P+ P L
Sbjct 2871 ALADAHTRGVAVD----WEAVLGRA--GLVDLPGYPFQGKR---FWLLPDRTTPRDELDG 2921
Query 468 AVER--WERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELIL 525
R W + S P A R R L V+ G + + E R ++
Sbjct 2922 WFYRVDWTEVPRSEPAALRGRWLVVVPEGHEEDGWTVEVRSALAEAGAEPEVTRGVGGLV 2981
Query 526 VIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAG 585
A+ GA+ LV LD A L TV VDA V
Sbjct 2982 GDCAGVVSLLALEGDGAVQTLVLVRELD------AEGIDAPLWTVTFGAVDAGSPVARPD 3035
Query 586 QAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTL 645
QA L + + E + +DLP DP L +TAVL G + +V +
Sbjct 3036 QAKLWGLGQVASLERGPRWTGLVDLPHMP-DPEL-RGRLTAVLAGSEDQV---AVRADAV 3090
Query 646 FERTLADA--PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD 703
R L+ A A +++ G ++VTGG +G AR+LA GA + L+SRR D
Sbjct 3091 RARRLSPAHVTATSEYAVPGGT---ILVTGGTAGLGAEVARWLAGRGAEHLALVSRRGPD 3147
Query 704 QATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIA---AEYGGVGASLIVHAAGSVISGT 757
V L + G + CD++ + + E G V +VHAAG
Sbjct 3148 TEGVGDLTAELTRLGARVSVHACDVSSREPVRELVHGLIEQGDV-VRGVVHAAGLPQQVA 3206
Query 758 APGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRT-LLCSSVMGVWGGHGVVAYSAANRL 816
+ AA + AAK G + EL D LL SS GVWG AY+A N
Sbjct 3207 INDMDEAAFDEVVAAKAGGAVHLDELC---SDAELFLLFSSGAGVWGSARQGAYAAGNAF 3263
Query 817 LDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAI-- 874
LD A R +G +V WGLW A G +AV+ R ER G+R M +A+
Sbjct 3264 LDAFARHRRGRGLPATSVAWGLWAAGG----MTGDEEAVSFLR-ER-GVRAMPVPRALAA 3317
Query 875 --------EASLHEFTVDPLVFAAD--AARLQMLLD----SRQFERYEGPTDPNL----- 915
E ++ VD FA AAR + LLD + ER P +L
Sbjct 3318 LDRVLASGETAVVVTDVDWPAFAESYTAARPRPLLDRIVTTAPSERAGEPETESLRDRLA 3377
Query 916 ---------TIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGA 966
+V VRT A VLG V +LG DS+ A+ LRN L + G
Sbjct 3378 GLPRAERTAELVRLVRTSTATVLGHDDPKAVRATTPFKELGFDSLAAVRLRNLLNAATGL 3437
Query 967 TVSLATLMGDITGDGLVAKLEDAD 990
+ +TL+ D VA DA+
Sbjct 3438 RLP-STLVFDHPNASAVAGFLDAE 3460
Score = 217 bits (552), Expect = 1e-53, Method: Compositional matrix adjust.
Identities = 283/1033 (28%), Positives = 425/1033 (42%), Gaps = 107/1033 (10%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
+LSA + E + A +A +L P ++A L R HRA D
Sbjct 1001 VLSASSAEGLRAQAARLAAHLREHPGQDPRDIAYSLATGRAALPHRAAFAPVDESAALRV 1060
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
L LA G +S R FVFPGQG W GM P + A CA A
Sbjct 1061 LDGLATGNADGAAVGTSRAQQ-RAVFVFPGQGWQWAGMAVDLLDTSPVFAAALRECADAL 1119
Query 134 AAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDLTVG 189
+P+L A E+ A E ++ F V+LA +WR+ GV P +G
Sbjct 1120 EPHLDFEVIPFLRAEAARREQDAALSTERVDVVQPVMFAVMVSLASMWRAHGVEPAAVIG 1179
Query 190 HSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGW 249
HS GE+AAA +AG+++L DA VVA R+ V+ +PG +A++ + A I G
Sbjct 1180 HSQGEIAAACVAGALSLDDAARVVALRSRVIATMPGNKGMASIAAPAGEVRARI---GDR 1236
Query 250 LELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQL 309
+E++ VN +V V+G+ + +V + + A+ + V + H+S +E++RD L +L
Sbjct 1237 VEIAAVNGPRSVVVAGDSDELDRLVASCTTECIRAKRLAVDYASHSSHVETIRDALHAEL 1296
Query 310 PDSEFMEAP--VQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIE 367
+ +F P V F TG P YWY NLR TVRF AV + G R F+E
Sbjct 1297 GE-DFHPLPGFVPFFSTVTGRWTQPDELDAGYWYRNLRRTVRFADAVRALAEQGYRTFLE 1355
Query 368 ISAHPALLFAIGQNCEGA-ANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPG 422
+SAHP L AI + +G+ A+L + S RRG+ F +ALS + D
Sbjct 1356 VSAHPILTAAIEEIGDGSGADLS-----AIHSLRRGDGSLADFGEALSRAFAAGVAVD-- 1408
Query 423 YPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPV- 481
W + L P P + +W P+P+ S V + P
Sbjct 1409 --WESVH---LGTGARRVPLPTYPFQRERVWLEPKPVARRSTEVDEVSALRYRIEWRPTG 1463
Query 482 AGRHRHLAVLDLGAHRA--LAQTLCAAIDSHPDTELSAARDAELIL-VIAPDFEHTDAVR 538
AG L L A A +T AA ++ E + AR EL++ E + +R
Sbjct 1464 AGEPARLDGTWLVAKYAGTADETSTAAREA---LESAGARVRELVVDARCGRDELAERLR 1520
Query 539 AAGALADLVGAGLLDY------PMHIGARCQSVCL---------------VTVGAEQVDA 577
+ G +A ++ +D P+ + + ++ L VT A
Sbjct 1521 SVGEVAGVLSLLAVDEAEPEEAPLALASLADTLSLVQAMVSAELGCPLWTVTESAVATGP 1580
Query 578 ADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALR 637
+ V +A AL + R I E+P +D+P+ + L + V G GE L
Sbjct 1581 FERVRNAAHGALWGVGRVIALENPAVWGGLVDVPAGSVAE-LARHLAAVVSGGAGEDQLA 1639
Query 638 GSVNGYTLFERTLADAPAVPN-WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVL 696
+G A APA + W VL G G I AR+LA GA ++L
Sbjct 1640 LRADGVYGRRWVRAAAPATDDEWKPTGTVLVTGGTGGVGGQI----ARWLARRGAPHLLL 1695
Query 697 LSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIAAEYGGVG----ASLIVHA 749
+SR D L + G CD+TD + + GG+G S + HA
Sbjct 1696 VSRSGPDADGAGELVAELEALGARTTVAACDVTDRESVREL---LGGIGDDVPLSAVFHA 1752
Query 750 AGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVA 809
A ++ GT +T + AKVLG + EL +L SS +G G+
Sbjct 1753 AATLDDGTVDTLTGERIERASRAKVLGARNLHELTRELDLTAFVLFSSFASAFGAPGLGG 1812
Query 810 YSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMA 869
Y+ N LD +A Q R+ G AV WG W G+A+ R R G+ +M
Sbjct 1813 YAPGNAYLDGLAQQRRSDGLPATAVAWGTWA-------GSGMAEGPVADRFRRHGVIEMP 1865
Query 870 PQ---QAIEASLHEFTVDPLVFAADAARLQMLLDSRQFERYEGPTDP------------- 913
P+ +A++ +L V P+V R + +++ R D
Sbjct 1866 PETACRALQNALDRAEVCPIVIDVRWDRFLLAYTAQRPTRLFDEIDDARRAAPQAAAEPR 1925
Query 914 ------------NLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLK 961
+ + VR+ AAVLG A V ++ +LGVDS+ AL+LRNRL
Sbjct 1926 VGALASLPAPEREKALFELVRSHAAAVLGHASAERVPADQAFAELGVDSLSALELRNRLG 1985
Query 962 RSIGATVSLATLM 974
+ G + T+
Sbjct 1986 AATGVRLPTTTVF 1998
Score = 130 bits (328), Expect = 9e-28, Method: Compositional matrix adjust.
Identities = 132/428 (31%), Positives = 194/428 (46%), Gaps = 23/428 (5%)
Query 15 LSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRR--HRAVLRAADRLELAE 72
LS E + AR + +L+RFP V V L + HRAV+ A+ EL +
Sbjct 24 LSGCNESALRARARQLRAHLDRFPDAGVEGVGAALAHDEQADAGPHRAVVVASSTSELLD 83
Query 73 GLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAA 132
GL A+A GR H + R + FVFPGQG W GM E + A D CA A
Sbjct 84 GLAAVADGRPHASVVRGVARPSAPVVFVFPGQGAQWAGMAGELLGESRVFAAAMDACARA 143
Query 133 FAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSL 192
F D L ++ P E+ E+ ++ A F +LA +WRS GV PD VGHS+
Sbjct 144 FEPV-TDWTLAQVLDSP---EQSRRVEV-VQPALFAVQTSLAALWRSFGVTPDAVVGHSI 198
Query 193 GEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLEL 252
GE+AAA++ G+ +DA A + + L G +AA+ + + IA + L
Sbjct 199 GELAAAHVCGAAGAADAARAAALWSREMIPLVGNGDMAAVALSADEIEPRIARWDDDVVL 258
Query 253 SVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTS----VLESLRDELCEQ 308
+ VN +V ++G + VA V + + G A+ I V H++ + E +R L
Sbjct 259 AGVNGPRSVLLTGSPEPVARRVQELSAEGVRAQVINVSMAAHSAQVDDIAEGMRSALAWF 318
Query 309 LPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEI 368
P + V F TG V DYW + R VRFD A+ SA+ G F+E
Sbjct 319 APGG----SEVPFYASLTGGAVDTRELVADYWRRSFRLPVRFDEAIRSALEVGPGTFVEA 374
Query 369 SAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPGYP 424
S HP L A+ Q + + A +V + +RG+ RF+ A + D
Sbjct 375 SPHPVLAAALQQTLDAEGS----SAAVVPTLQRGQGGMRRFLLAAAQAFTGGVAVDWTAA 430
Query 425 WGDLGGDP 432
+ D+G +P
Sbjct 431 YDDVGAEP 438
>gi|291010105|ref|ZP_06568078.1| EryAI erythromycin polyketide synthase modules 1 and 2 [Saccharopolyspora
erythraea NRRL 2338]
Length=1182
Score = 241 bits (614), Expect = 6e-61, Method: Compositional matrix adjust.
Identities = 313/1044 (30%), Positives = 437/1044 (42%), Gaps = 108/1044 (10%)
Query 4 KQLP-DGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
+ LP G V V+LSA + A +AD+L P +V+ + + R+ RA +
Sbjct 105 RMLPATGVVPVVLSARTGAALRAQAGRLADHLAAHPGIAPADVSWTMARARQHFEERAAV 164
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL--- 119
AAD E LRA+A G P + S S FVFPGQG W GM REL
Sbjct 165 LAADTAEAVHRLRAVADGAVVPGVVTGS-ASDGGSVFVFPGQGAQWEGMA----RELLPV 219
Query 120 PTYRTATDTC------AAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVAL 173
P + + C A F+ + V P P + D Q F V+L
Sbjct 220 PVFAESIAECDAVLSEVAGFSVSEVLEPRPDAPSLERVDVVQPVL--------FAVMVSL 271
Query 174 AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG 233
A +WR+CG +P +GHS GE+AAA +AG+++L D + VVA R+ V + GR ++ ++
Sbjct 272 ARLWRACGAVPSAVIGHSQGEIAAAVVAGALSLEDGMRVVARRSRAVRAVAGRGSMLSVR 331
Query 234 IGEQDASALIA--TTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGF 291
G D L+A + G LE++ VN V V+G+ QA ++ G AR I V +
Sbjct 332 GGRSDVEKLLADDSWTGRLEVAAVNGPDAVVVAGDAQAAREFLEYCEGVGIRARAIPVDY 391
Query 292 PVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFD 351
HT+ +E +RDEL + L A V F TGD + YWY NLRH V F
Sbjct 392 ASHTAHVEPVRDELVQALAGITPRRAEVPFFSTLTGDFLDGTELDAGYWYRNLRHPVEFH 451
Query 352 RAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARR----GERFVD 407
AV++ G FIE+S HP L ++ + + A + A ++G+ R +RF+
Sbjct 452 SAVQALTDQGYATFIEVSPHPVLASSVQETLDDA----ESDAAVLGTLERDAGDADRFLT 507
Query 408 ALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTI 467
AL+ D W + G G VDL G+P R W P+ P L
Sbjct 508 ALADAHTRGVAVD----WEAVLGRA--GLVDLPGYPFQGKR---FWLLPDRTTPRDELDG 558
Query 468 AVER--WERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELIL 525
R W + S P A R R L V+ G + + E R ++
Sbjct 559 WFYRVDWTEVPRSEPAALRGRWLVVVPEGHEEDGWTVEVRSALAEAGAEPEVTRGVGGLV 618
Query 526 VIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAG 585
A+ GA+ LV LD A L TV VDA V
Sbjct 619 GDCAGVVSLLALEGDGAVQTLVLVRELD------AEGIDAPLWTVTFGAVDAGSPVARPD 672
Query 586 QAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTL 645
QA L + + E + +DLP DP L +TAVL G + +V +
Sbjct 673 QAKLWGLGQVASLERGPRWTGLVDLPHMP-DPEL-RGRLTAVLAGSEDQV---AVRADAV 727
Query 646 FERTLADA--PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD 703
R L+ A A +++ G ++VTGG +G AR+LA GA + L+SRR D
Sbjct 728 RARRLSPAHVTATSEYAVPGGT---ILVTGGTAGLGAEVARWLAGRGAEHLALVSRRGPD 784
Query 704 QATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIA---AEYGGVGASLIVHAAGSVISGT 757
V L + G + CD++ + + E G V +VHAAG
Sbjct 785 TEGVGDLTAELTRLGARVSVHACDVSSREPVRELVHGLIEQGDV-VRGVVHAAGLPQQVA 843
Query 758 APGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRT-LLCSSVMGVWGGHGVVAYSAANRL 816
+ AA + AAK G + EL D LL SS GVWG AY+A N
Sbjct 844 INDMDEAAFDEVVAAKAGGAVHLDELC---SDAELFLLFSSGAGVWGSARQGAYAAGNAF 900
Query 817 LDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAI-- 874
LD A R +G +V WGLW A G +AV+ R ER G+R M +A+
Sbjct 901 LDAFARHRRGRGLPATSVAWGLWAAGG----MTGDEEAVSFLR-ER-GVRAMPVPRALAA 954
Query 875 --------EASLHEFTVDPLVFAAD--AARLQMLLD----SRQFERYEGPTDPNL----- 915
E ++ VD FA AAR + LLD + ER P +L
Sbjct 955 LDRVLASGETAVVVTDVDWPAFAESYTAARPRPLLDRIVTTAPSERAGEPETESLRDRLA 1014
Query 916 ---------TIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGA 966
+V VRT A VLG V +LG DS+ A+ LRN L + G
Sbjct 1015 GLPRAERTAELVRLVRTSTATVLGHDDPKAVRATTPFKELGFDSLAAVRLRNLLNAATGL 1074
Query 967 TVSLATLMGDITGDGLVAKLEDAD 990
+ +TL+ D VA DA+
Sbjct 1075 RLP-STLVFDHPNASAVAGFLDAE 1097
>gi|416965|sp|Q03131.1|ERYA1_SACER RecName: Full=Erythronolide synthase, modules 1 and 2; AltName:
Full=6-deoxyerythronolide B synthase I; AltName: Full=DEBS
1; AltName: Full=ORF 1
gi|7264827|gb|AAA26493.2| EryA [Saccharopolyspora erythraea]
Length=3491
Score = 241 bits (614), Expect = 7e-61, Method: Compositional matrix adjust.
Identities = 313/1044 (30%), Positives = 437/1044 (42%), Gaps = 108/1044 (10%)
Query 4 KQLP-DGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVL 62
+ LP G V V+LSA + A +AD+L P +V+ + + R+ RA +
Sbjct 2414 RMLPATGVVPVVLSARTGAALRAQAGRLADHLAAHPGIAPADVSWTMARARQHFEERAAV 2473
Query 63 RAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL--- 119
AAD E LRA+A G P + S S FVFPGQG W GM REL
Sbjct 2474 LAADTAEAVHRLRAVADGAVVPGVVTGS-ASDGGSVFVFPGQGAQWEGMA----RELLPV 2528
Query 120 PTYRTATDTC------AAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVAL 173
P + + C A F+ + V P P + D Q F V+L
Sbjct 2529 PVFAESIAECDAVLSEVAGFSVSEVLEPRPDAPSLERVDVVQPVL--------FAVMVSL 2580
Query 174 AEVWRSCGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALG 233
A +WR+CG +P +GHS GE+AAA +AG+++L D + VVA R+ V + GR ++ ++
Sbjct 2581 ARLWRACGAVPSAVIGHSQGEIAAAVVAGALSLEDGMRVVARRSRAVRAVAGRGSMLSVR 2640
Query 234 IGEQDASALIA--TTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGF 291
G D L+A + G LE++ VN V V+G+ QA ++ G AR I V +
Sbjct 2641 GGRSDVEKLLADDSWTGRLEVAAVNGPDAVVVAGDAQAAREFLEYCEGVGIRARAIPVDY 2700
Query 292 PVHTSVLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFD 351
HT+ +E +RDEL + L A V F TGD + YWY NLRH V F
Sbjct 2701 ASHTAHVEPVRDELVQALAGITPRRAEVPFFSTLTGDFLDGTELDAGYWYRNLRHPVEFH 2760
Query 352 RAVESAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARR----GERFVD 407
AV++ G FIE+S HP L ++ + + A + A ++G+ R +RF+
Sbjct 2761 SAVQALTDQGYATFIEVSPHPVLASSVQETLDDA----ESDAAVLGTLERDAGDADRFLT 2816
Query 408 ALSANIVSAAVADPGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTI 467
AL+ D W + G G VDL G+P R W P+ P L
Sbjct 2817 ALADAHTRGVAVD----WEAVLGRA--GLVDLPGYPFQGKR---FWLLPDRTTPRDELDG 2867
Query 468 AVER--WERMVPSTPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELIL 525
R W + S P A R R L V+ G + + E R ++
Sbjct 2868 WFYRVDWTEVPRSEPAALRGRWLVVVPEGHEEDGWTVEVRSALAEAGAEPEVTRGVGGLV 2927
Query 526 VIAPDFEHTDAVRAAGALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAG 585
A+ GA+ LV LD A L TV VDA V
Sbjct 2928 GDCAGVVSLLALEGDGAVQTLVLVRELD------AEGIDAPLWTVTFGAVDAGSPVARPD 2981
Query 586 QAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTL 645
QA L + + E + +DLP DP L +TAVL G + +V +
Sbjct 2982 QAKLWGLGQVASLERGPRWTGLVDLPHMP-DPEL-RGRLTAVLAGSEDQV---AVRADAV 3036
Query 646 FERTLADA--PAVPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAAD 703
R L+ A A +++ G ++VTGG +G AR+LA GA + L+SRR D
Sbjct 3037 RARRLSPAHVTATSEYAVPGGT---ILVTGGTAGLGAEVARWLAGRGAEHLALVSRRGPD 3093
Query 704 QATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIA---AEYGGVGASLIVHAAGSVISGT 757
V L + G + CD++ + + E G V +VHAAG
Sbjct 3094 TEGVGDLTAELTRLGARVSVHACDVSSREPVRELVHGLIEQGDV-VRGVVHAAGLPQQVA 3152
Query 758 APGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRT-LLCSSVMGVWGGHGVVAYSAANRL 816
+ AA + AAK G + EL D LL SS GVWG AY+A N
Sbjct 3153 INDMDEAAFDEVVAAKAGGAVHLDELC---SDAELFLLFSSGAGVWGSARQGAYAAGNAF 3209
Query 817 LDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAI-- 874
LD A R +G +V WGLW A G +AV+ R ER G+R M +A+
Sbjct 3210 LDAFARHRRGRGLPATSVAWGLWAAGG----MTGDEEAVSFLR-ER-GVRAMPVPRALAA 3263
Query 875 --------EASLHEFTVDPLVFAAD--AARLQMLLD----SRQFERYEGPTDPNL----- 915
E ++ VD FA AAR + LLD + ER P +L
Sbjct 3264 LDRVLASGETAVVVTDVDWPAFAESYTAARPRPLLDRIVTTAPSERAGEPETESLRDRLA 3323
Query 916 ---------TIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIGA 966
+V VRT A VLG V +LG DS+ A+ LRN L + G
Sbjct 3324 GLPRAERTAELVRLVRTSTATVLGHDDPKAVRATTPFKELGFDSLAAVRLRNLLNAATGL 3383
Query 967 TVSLATLMGDITGDGLVAKLEDAD 990
+ +TL+ D VA DA+
Sbjct 3384 RLP-STLVFDHPNASAVAGFLDAE 3406
Score = 218 bits (555), Expect = 4e-54, Method: Compositional matrix adjust.
Identities = 286/1033 (28%), Positives = 429/1033 (42%), Gaps = 107/1033 (10%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
+LSA + E + A +A +L P ++A L R HRA D
Sbjct 948 VLSASSAEGLRAQAARLAAHLREHPGQDPRDIAYSLATGRAALPHRAAFAPVDESAALRV 1007
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
L LA G +S R FVFPGQG W GM P + A CA A
Sbjct 1008 LDGLATGNADGAAVGTSRAQQ-RAVFVFPGQGWQWAGMAVDLLDTSPVFAAALRECADAL 1066
Query 134 AAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDLTVG 189
+P+L A E+ A E ++ F V+LA +WR+ GV P +G
Sbjct 1067 EPHLDFEVIPFLRAEAARREQDAALSTERVDVVQPVMFAVMVSLASMWRAHGVEPAAVIG 1126
Query 190 HSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGW 249
HS GE+AAA +AG+++L DA VVA R+ V+ +PG +A++ + A I G
Sbjct 1127 HSQGEIAAACVAGALSLDDAARVVALRSRVIATMPGNKGMASIAAPAGEVRARI---GDR 1183
Query 250 LELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQL 309
+E++ VN +V V+G+ + +V + + A+ + V + H+S +E++RD L +L
Sbjct 1184 VEIAAVNGPRSVVVAGDSDELDRLVASCTTECIRAKRLAVDYASHSSHVETIRDALHAEL 1243
Query 310 PDSEFMEAP--VQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIE 367
+ +F P V F TG P YWY NLR TVRF AV + G R F+E
Sbjct 1244 GE-DFHPLPGFVPFFSTVTGRWTQPDELDAGYWYRNLRRTVRFADAVRALAEQGYRTFLE 1302
Query 368 ISAHPALLFAIGQNCEGA-ANLPDGPAVLVGSARRGE----RFVDALSANIVSAAVADPG 422
+SAHP L AI + +G+ A+L + S RRG+ F +ALS + D
Sbjct 1303 VSAHPILTAAIEEIGDGSGADLS-----AIHSLRRGDGSLADFGEALSRAFAAGVAVD-- 1355
Query 423 YPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPV- 481
W + L P P + +W P+P+ S V + P
Sbjct 1356 --WESVH---LGTGARRVPLPTYPFQRERVWLEPKPVARRSTEVDEVSALRYRIEWRPTG 1410
Query 482 AGRHRHLAVLDLGAHRA--LAQTLCAAIDSHPDTELSAARDAELIL-VIAPDFEHTDAVR 538
AG L L A A +T AA ++ E + AR EL++ E + +R
Sbjct 1411 AGEPARLDGTWLVAKYAGTADETSTAAREA---LESAGARVRELVVDARCGRDELAERLR 1467
Query 539 AAGALADLVGAGLLDY------PMHIGARCQSVCL---------------VTVGAEQVDA 577
+ G +A ++ +D P+ + + ++ L VT A
Sbjct 1468 SVGEVAGVLSLLAVDEAEPEEAPLALASLADTLSLVQAMVSAELGCPLWTVTESAVATGP 1527
Query 578 ADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALR 637
+ V +A AL + R I E+P +D+P+ + L + V G GE L
Sbjct 1528 FERVRNAAHGALWGVGRVIALENPAVWGGLVDVPAGSVAE-LARHLAAVVSGGAGEDQLA 1586
Query 638 GSVNGYTLFERTLADAPAVPN-WSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVL 696
+G A APA + W VL G G I AR+LA GA ++L
Sbjct 1587 LRADGVYGRRWVRAAAPATDDEWKPTGTVLVTGGTGGVGGQI----ARWLARRGAPHLLL 1642
Query 697 LSRRAADQATVAMLRKQ---HGTVIVSPPCDITDPTQLSAIAAEYGGVG----ASLIVHA 749
+SR D L + G CD+TD + + GG+G S + HA
Sbjct 1643 VSRSGPDADGAGELVAELEALGARTTVAACDVTDRESVREL---LGGIGDDVPLSAVFHA 1699
Query 750 AGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCSSVMGVWGGHGVVA 809
A ++ GT +T + AKVLG + EL +L SS +G G+
Sbjct 1700 AATLDDGTVDTLTGERIERASRAKVLGARNLHELTRELDLTAFVLFSSFASAFGAPGLGG 1759
Query 810 YSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMA 869
Y+ N LD +A Q R+ G AV WG W G+A+ R R G+ +M
Sbjct 1760 YAPGNAYLDGLAQQRRSDGLPATAVAWGTWA-------GSGMAEGAVADRFRRHGVIEMP 1812
Query 870 PQ---QAIEASLHEFTVDPLVF------------AADAARLQMLLDSRQFERYEGPTDPN 914
P+ +A++ +L V P+V A RL +D + + P +P
Sbjct 1813 PETACRALQNALDRAEVCPIVIDVRWDRFLLAYTAQRPTRLFDEIDDARRAAPQAPAEPR 1872
Query 915 L-------------TIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLK 961
+ + + VR+ AAVLG A V ++ +LGVDS+ AL+LRNRL
Sbjct 1873 VGALASLPAPEREEALFELVRSHAAAVLGHASAERVPADQAFAELGVDSLSALELRNRLG 1932
Query 962 RSIGATVSLATLM 974
+ G + T+
Sbjct 1933 AATGVRLPTTTVF 1945
Score = 118 bits (295), Expect = 6e-24, Method: Compositional matrix adjust.
Identities = 118/381 (31%), Positives = 175/381 (46%), Gaps = 21/381 (5%)
Query 60 AVLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYREL 119
AV+ A+ EL +GL A+A GR H + R + FVFPGQG W GM E
Sbjct 19 AVVVASSTSELLDGLAAVADGRPHASVVRGVARPSAPVVFVFPGQGAQWAGMAGELLGES 78
Query 120 PTYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRS 179
+ A D CA AF D L ++ P E+ E+ ++ A F +LA +WRS
Sbjct 79 RVFAAAMDACARAFEPV-TDWTLAQVLDSP---EQSRRVEV-VQPALFAVQTSLAALWRS 133
Query 180 CGVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDA 239
GV PD VGHS+GE+AAA++ G+ +DA A + + L G +AA+ + +
Sbjct 134 FGVTPDAVVGHSIGELAAAHVCGAAGAADAARAAALWSREMIPLVGNGDMAAVALSADEI 193
Query 240 SALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTS--- 296
IA + L+ VN +V ++G + VA V + + G A+ I V H++
Sbjct 194 EPRIARWDDDVVLAGVNGPRSVLLTGSPEPVARRVQELSAEGVRAQVINVSMAAHSAQVD 253
Query 297 -VLESLRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVE 355
+ E +R L P + V F TG V DYW + R VRFD A+
Sbjct 254 DIAEGMRSALAWFAPGG----SEVPFYASLTGGAVDTRELVADYWRRSFRLPVRFDEAIR 309
Query 356 SAIRCGARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGE----RFVDALSA 411
SA+ G F+E S HP L A+ Q + + A +V + +RG+ RF+ A +
Sbjct 310 SALEVGPGTFVEASPHPVLAAALQQTLDAEGS----SAAVVPTLQRGQGGMRRFLLAAAQ 365
Query 412 NIVSAAVADPGYPWGDLGGDP 432
D + D+G +P
Sbjct 366 AFTGGVAVDWTAAYDDVGPNP 386
>gi|43336421|gb|AAS46345.1| NlmA7 [Streptomyces nanchangensis]
Length=3593
Score = 238 bits (607), Expect = 4e-60, Method: Compositional matrix adjust.
Identities = 313/1071 (30%), Positives = 447/1071 (42%), Gaps = 163/1071 (15%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
L+S + E + A + +L P ++ L +R HRAVL +
Sbjct 488 LISGNTEAALREQAARLRAHLNAHPGLAAADIGHSLLTSRTRFAHRAVLLTEQDGDRRTA 547
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
L ALA G + P + R + + FVFPGQG W GMG + + + C A
Sbjct 548 LTALADGLDAPGLIRGTGDTGAGVVFVFPGQGSQWVGMGRELWEVSSVFAESMVACERAL 607
Query 134 AAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSLG 193
A V L ++ G + ++ ++ + V+LA VWRS GV P VGHS G
Sbjct 608 APF-VGWSLRDVVFEGGGEGLWGRVDV-VQPVLWAVMVSLAAVWRSFGVEPVGVVGHSQG 665
Query 194 EVAAAYLAGSITLSDAVAVVAARANVVG-RLPGRYAVAALGIGEQDASALIATTGGWLEL 252
EVAAA +AG ++L D VVA R+ +VG RL GR + ++ + +A +GG + +
Sbjct 666 EVAAACVAGGLSLEDGARVVAVRSRLVGERLSGRGGMVSVTLPVAQVEEWLAGSGGRVGV 725
Query 253 SVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDS 312
+ VN S+V VSGE +A+ ++ + +G AR I V + H++ +++L D+L L D
Sbjct 726 AAVNGPSSVVVSGEVEALDGLLVELDGAGVRARRIAVDYASHSAQVDALNDDLLAGLADI 785
Query 313 EFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHP 372
+ +PV F TG+ + YW ANLR V F+ V + + F+E S HP
Sbjct 786 RPVSSPVAFYSTVTGERMDTAGLDAAYWAANLRERVLFEPVVRTLAELEHQVFVESSPHP 845
Query 373 ALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWGDLGGDP 432
L A+ + E A+ G VGS RR + A++ A VA W L
Sbjct 846 VLAMAVQETLESAS----GAGAAVGSLRRDDGGAGRFLASLAEAYVAGAPVDWSVLFEGT 901
Query 433 LDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTI--------AVER------------- 471
VDL P + W P G+ AVER
Sbjct 902 GTRRVDL---PTYAFQHQRYWLEDASAPGAEGVVDPVDAAFWGAVERADVQGVAALVDGS 958
Query 472 ----WERMVP--STPVAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELIL 525
WE +VP S GR +VLD +R T A T LS + L
Sbjct 959 VPGVWEPVVPVLSAWRKGREER-SVLDSWRYR----TTWRAFSLPSGTRLSG-----MWL 1008
Query 526 VI-----APDFEHTDAVRAAGA----LADLVGAGLLDYPMHI--------GARCQSVCLV 568
V+ AP E A+ AAGA ADL GA L + A +V LV
Sbjct 1009 VVASGGDAPVDEVRQALEAAGAEVCVRADLDGAALAGVSGVVSLLAWDEGSAVVSTVGLV 1068
Query 569 --------------TVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPS-W 613
T GA V D V SA Q+ + A+ + +G E P +D+P W
Sbjct 1069 QACGGGGEVPLWVLTRGAAVVGVDDPV-SAVQSQVWALGQVVGLEQPGGWGGLVDVPGVW 1127
Query 614 DLDPVLGVSVITAVLRGFGETALRGS-VNGYTLFERTLADAPA-VPNWSLDSGVLDDVVV 671
D ++ + A G + A+R S G L L +P V WS L V
Sbjct 1128 DERVASLLAGVLAAGGGEDQVAVRSSGAYGRRLVRAPLGASPVRVREWSPSGTAL----V 1183
Query 672 TGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTV---IVSPPCDITDP 728
TGG G IG H AR+LA G ++L+SRR + VA L ++ G + + CD+TD
Sbjct 1184 TGGTGGIGGHLARWLAREGVGHLLLVSRRGPEAEGVAELVEELGGLGVEVTVVACDVTDR 1243
Query 729 TQ----LSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELW 784
L+ I AEY + + HAAG G + +A + AAK LG + EL
Sbjct 1244 AALAELLATIPAEY---PLTSVFHAAGIAGYGLVRELDAAGLDAEMAAKTLGARHLDELT 1300
Query 785 -PLRPDVRTLLC-SSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAP 842
L D+ + SS VWG G Y+AAN LD +A + RA+G +V WG W+
Sbjct 1301 AELGLDLDAFVVFSSGAAVWGSAGSGGYAAANAYLDGLARERRARGLVATSVSWGNWK-- 1358
Query 843 KAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVD------------------ 884
G+A T ++ R G+R M P+ A+ A D
Sbjct 1359 -----NTGLATDTTAEQLTRIGVRPMEPELAVRALRQALEQDEVSMTVADMDWSLFTPGY 1413
Query 885 ------PLV---------FAADAA---------------RLQMLLDSRQFERYEGPTDPN 914
PL+ + D+A L L +S Q ER
Sbjct 1414 ALARRRPLIEEIPEAARALSEDSADPANDTVGGDSPLRQSLAALTESEQHER-------- 1465
Query 915 LTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
++ AVRT+ AAVL E+ + DLG DS+ A++LRNRL + G
Sbjct 1466 --LLGAVRTEAAAVLTHSTTDEITAGKPFRDLGFDSLTAMELRNRLNAATG 1514
Score = 119 bits (298), Expect = 3e-24, Method: Compositional matrix adjust.
Identities = 106/362 (30%), Positives = 163/362 (46%), Gaps = 20/362 (5%)
Query 14 LLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLELAEG 73
++SA +E+ + AR +A +L V +V L TR HRAVL + E
Sbjct 2000 VISARSEQALREQARRLAGHLRAHDLRPV-DVGFSLATTRAGLEHRAVLVGRETSEFLAQ 2058
Query 74 LRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCAAAF 133
L +A + P+ S AF+F GQG GMG Y P + A D
Sbjct 2059 LETVAG--DGPV-------SEGGTAFLFSGQGSQRAGMGRELYEAYPVFAAAFDEVCGHL 2109
Query 134 AAAGVDSPLPYLIAPPGTD-ERQAFCEIEIEGAQFVHAVALAEVWRSCGVLPDLTVGHSL 192
++ P+ ++ G +R F + + F VAL E+ S GV D+ +GHS+
Sbjct 2110 DVL-LERPVKEVVFAGGKALDRTVFTQAGL----FALEVALFELVGSWGVRADVLLGHSI 2164
Query 193 GEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATTGGWLEL 252
GE+AAAY AG +L DA VVAAR ++ LP + A+ E++ L A + +
Sbjct 2165 GELAAAYAAGVWSLEDACRVVAARGRLMQALPEGGVMVAVEAAEEELPQLPAG----VSV 2220
Query 253 SVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELCEQLPDS 312
+ VN ++ +SG+ + V A+ T G R +TV H++ +E + + E L
Sbjct 2221 AAVNGPRSLVLSGDDEPVTALAQTFAGQGRRTRRLTVSHAFHSAWMEPMLADFAEVLGSV 2280
Query 313 EFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFIEISAHP 372
EF + + TG V DYW ++R VRF V + + G F+E+
Sbjct 2281 EFRAPRIPVVSNVTGQVAGEELATPDYWVRHVREAVRFADGVTTVLGRGVDKFLELGPGG 2340
Query 373 AL 374
AL
Sbjct 2341 AL 2342
Score = 92.4 bits (228), Expect = 3e-16, Method: Compositional matrix adjust.
Identities = 131/464 (29%), Positives = 189/464 (41%), Gaps = 54/464 (11%)
Query 565 VCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEHPEQTFSHLDLPSWDLDPVLGVSVI 624
+ L+T GA D + +A+ + R+ EHP++ +DL D DP ++
Sbjct 2833 LVLLTRGAVPAVDTDRIEDLAASAVWGLVRAAQSEHPDRIV-LIDL---DDDPTSYRALP 2888
Query 625 TAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWSLDSGVLDDVVVTGGAGAIGMHYAR 684
A+ G + ALR R P + D VL VTGG GA+G AR
Sbjct 2889 AALGTGEPQLALRTGAASAPRLARHTGAPEVTPGFGPDGTVL----VTGGTGALGAVVAR 2944
Query 685 YLAE-HGARRIVLLSRRAADQATVAMLR---KQHGTVIVSPPCDITD----PTQLSAIAA 736
+LA HG R +VL SR A+ + L + G CD++D L AI A
Sbjct 2945 HLAAAHGVRHLVLASRSGAEASGADALLADLTELGADATIVACDVSDRAALAALLDAIPA 3004
Query 737 EYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQMIELWPLRPDVRTLLCS 796
E G +VH AG + GT +T AK + EL L P +L S
Sbjct 3005 ERPLTG---VVHTAGVLADGTVESLTPDQADTVLRAKADAAWHLHELTALTPVREFVLFS 3061
Query 797 SVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQAPKAGEPARGIADAVT 856
S G+ G G Y+AAN LD +AA RA G ++ WG W P G A+
Sbjct 3062 SAAGLLGSQGQGNYAAANAFLDALAAHRRAAGLAGTSLAWGWWDLPGGMAADLGRAER-- 3119
Query 857 IARVERSGLRQMAPQQAIEASLHEFT--VDPLVF----------AADAARLQMLLD---- 900
AR+ R GL + ++A +PL+ A+ ++ +L
Sbjct 3120 -ARMARGGLTPFTAETGMDAFDQTLAAGTEPLLVPMRMNTAVARASAGQQIPSVLRGLVR 3178
Query 901 --------------SRQFERYEGPT-DPNLTIV-DAVRTQLAAVLGIPQAGEVNLQESLF 944
SR ER G D L ++ + VR + A VLG A V S
Sbjct 3179 APRRRAVRSDEGSASRLRERLAGANADERLAMLTELVRVEAAQVLGHSGAEAVEDGSSFA 3238
Query 945 DLGVDSMLALDLRNRLKRSIGATVSLATLMGDITGDGLVAKLED 988
+LG DS+ +++LRNR+ G ++ + T L A+L D
Sbjct 3239 ELGFDSLTSVELRNRIGERTGLRLASTVVFDHPTPAALAAELGD 3282
>gi|291009294|ref|ZP_06567267.1| EryAIII erythromycin polyketide synthase modules 5 and 6 [Saccharopolyspora
erythraea NRRL 2338]
Length=1339
Score = 234 bits (598), Expect = 5e-59, Method: Compositional matrix adjust.
Identities = 301/1006 (30%), Positives = 437/1006 (44%), Gaps = 121/1006 (12%)
Query 11 VAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRAVLRAADRLEL 70
V VLLSA E + AR + ++ + +T +A L R RA L A D +L
Sbjct 101 VPVLLSARTETALAAQARLLESAVDD--SVPLTALASALATGRAHLPRRAALLAGDHEQL 158
Query 71 AEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELPTYRTATDTCA 130
LRA+A G P A + SA FVFPGQG W GM A +P + + C
Sbjct 159 RGQLRAVAEGVAAP-GATTGTASAGGVVFVFPGQGAQWEGM-ARGLLSVPVFAESIAECD 216
Query 131 AAFAAAGVDSPLPYLIAPPGTDERQAFCEIE----IEGAQFVHAVALAEVWRSCGVLPDL 186
A + S L ++R +E ++ F V+LA +W +CGV P
Sbjct 217 AVLSEVAGFSASEVL------EQRPDAPSLERVDVVQPVLFSVMVSLARLWGACGVSPSA 270
Query 187 TVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDASALIATT 246
+GHS GE+AAA +AG ++L D V VVA RA + L G+ + +L + A ALIA
Sbjct 271 VIGHSQGEIAAAVVAGVLSLEDGVRVVALRAKALRALAGKGGMVSLAAPGERARALIAPW 330
Query 247 GGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLESLRDELC 306
+ ++ VN+ S+V VSG+ +A+A +V G A+ + V + H+ +E +R+ +
Sbjct 331 EDRISVAAVNSPSSVVVSGDPEALAELVARCEDEGVRAKTLPVDYASHSRHVEEIRETIL 390
Query 307 EQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRCGARAFI 366
L A + G+ YWY NLR VRFD AV +A+ G F+
Sbjct 391 ADLDGISARRAAIPLYSTLHGERRDGADMGPRYWYDNLRSQVRFDEAVSAAVADGHATFV 450
Query 367 EISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVADPGYPWG 426
E+S HP L A+ E AA+ AV +GS R + + L A + A V W
Sbjct 451 EMSPHPVLTAAV---QEIAAD-----AVAIGSLHR-DTAEEHLIAELARAHVHGVAVDWR 501
Query 427 DLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTPVAGRHR 486
++ P V L +P P R W PE ++ V+ W R + +TPV
Sbjct 502 NV--FPAAPPVALPNYPFEPQR---YWLAPEVSDQLADSRYRVD-W-RPLATTPVDLEGG 554
Query 487 HLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAV------RAA 540
L H + ++L +A++ ++ V + D E A A
Sbjct 555 FL------VHGSAPESLTSAVEK---------AGGRVVPVASADREALAAALREVPGEVA 599
Query 541 GALADLVGAGL-LDYPMHIGARCQSVCLVTVGAEQVDAADAVP-SAGQAALAAMHRSIGF 598
G L+ GA L +G L V + V ++ P QA + + R +G
Sbjct 600 GVLSVHTGAATHLALHQSLGEAGVRAPLWLVTSRAVALGESEPVDPEQAMVWGLGRVMGL 659
Query 599 EHPEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAP---A 655
E PE+ +DLP+ +P G G + ++ + + R L AP
Sbjct 660 ETPERWGGLVDLPA---EPAPGDGEAFVACLGADGHEDQVAIRDHARYGRRLVRAPLGTR 716
Query 656 VPNWSLDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQ-- 713
+W L VTGG GA+G H AR+LA G +VL+SRR D A L +
Sbjct 717 ESSWEPAGTAL----VTGGTGALGGHVARHLARCGVEDLVLVSRRGVDAPGAAELEAELV 772
Query 714 -HGTVIVSPPCDITDPTQLSAIAAEYGGVGASL--IVHAAGSVISGTAPGVTSAAVVDNF 770
G CD+ D QLS + E G G + +VH AG + + P +
Sbjct 773 ALGAKTTITACDVADREQLSKLLEELRGQGRPVRTVVHTAG--VPESRPLHEIGELESVC 830
Query 771 AAKVLGLAQMIELWPLRPDVRTL-LCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGR 829
AAKV G + EL PD T L SS GVWG + AYSAAN LD +A + RA+GR
Sbjct 831 AAKVTGARLLDELC---PDAETFVLFSSGAGVWGSANLGAYSAANAYLDALAHRRRAEGR 887
Query 830 HCVAVKWGLWQAPKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEF--TVDPLV 887
+V WG W AGE G+A + + R GLR MAP++AI A LH+ D V
Sbjct 888 AATSVAWGAW----AGE---GMATG-DLEGLTRRGLRPMAPERAIRA-LHQALDNGDTCV 938
Query 888 FAAD-----------AARLQMLLDS-----------------RQFERYEGPTDPNLTIVD 919
AD AAR + LLD R+ E +++
Sbjct 939 SIADVDWERFAVGFTAARPRPLLDELVTPAVGAVPAVQAAPAREMTSQE--------LLE 990
Query 920 AVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRLKRSIG 965
+ +AA+LG V + +LG DS+ A+ LRN+L+++ G
Sbjct 991 FTHSHVAAILGHSSPDAVGQDQPFTELGFDSLTAVGLRNQLQQATG 1036
Lambda K H
0.320 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Effective search space used: 2506858661552
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
Posted date: Sep 5, 2011 4:36 AM
Number of letters in database: 5,219,829,388
Number of sequences in database: 15,229,318
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40