BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2447c Length=487 Score E Sequences producing significant alignments: (Bits) Value gi|15609584|ref|NP_216963.1| folylpolyglutamate synthase protein... 962 0.0 gi|254551497|ref|ZP_05141944.1| folylpolyglutamate synthase folC... 961 0.0 gi|340627461|ref|YP_004745913.1| putative folylpolyglutamate syn... 960 0.0 gi|344220276|gb|AEN00907.1| folylpolyglutamate synthase protein ... 960 0.0 gi|298525926|ref|ZP_07013335.1| folylpolyglutamate synthase prot... 959 0.0 gi|193506586|pdb|2VOS|A Chain A, Mycobacterium Tuberculosis Foly... 941 0.0 gi|308232135|ref|ZP_07415055.2| folylpolyglutamate synthase folC... 927 0.0 gi|308375894|ref|ZP_07445438.2| folylpolyglutamate synthase folC... 854 0.0 gi|342857845|ref|ZP_08714501.1| folylpolyglutamate synthase prot... 755 0.0 gi|254821842|ref|ZP_05226843.1| FolC protein [Mycobacterium intr... 746 0.0 gi|296170486|ref|ZP_06852073.1| tetrahydrofolate synthase [Mycob... 741 0.0 gi|15827773|ref|NP_302036.1| folylpolyglutamate synthase [Mycoba... 728 0.0 gi|41408368|ref|NP_961204.1| hypothetical protein MAP2270c [Myco... 721 0.0 gi|118464061|ref|YP_880952.1| FolC protein [Mycobacterium avium ... 720 0.0 gi|254774540|ref|ZP_05216056.1| FolC protein [Mycobacterium aviu... 716 0.0 gi|333990100|ref|YP_004522714.1| folylpolyglutamate synthase pro... 703 0.0 gi|240170919|ref|ZP_04749578.1| folylpolyglutamate synthase prot... 703 0.0 gi|183983751|ref|YP_001852042.1| folylpolyglutamate synthase pro... 683 0.0 gi|118618979|ref|YP_907311.1| folylpolyglutamate synthase protei... 679 0.0 gi|169628694|ref|YP_001702343.1| folylpolyglutamate synthase Fol... 659 0.0 gi|120404904|ref|YP_954733.1| FolC bifunctional protein [Mycobac... 654 0.0 gi|126436139|ref|YP_001071830.1| FolC bifunctional protein [Myco... 638 0.0 gi|108800523|ref|YP_640720.1| FolC bifunctional protein [Mycobac... 638 0.0 gi|145223218|ref|YP_001133896.1| FolC bifunctional protein [Myco... 633 2e-179 gi|54023316|ref|YP_117558.1| putative folylpolyglutamate synthet... 610 2e-172 gi|312140348|ref|YP_004007684.1| dihydrofolate synthetase/folylp... 595 5e-168 gi|333918790|ref|YP_004492371.1| putative folylpolyglutamate syn... 595 6e-168 gi|325677075|ref|ZP_08156744.1| tetrahydrofolate synthase [Rhodo... 594 1e-167 gi|226360453|ref|YP_002778231.1| folylpolyglutamate synthase [Rh... 592 7e-167 gi|111018327|ref|YP_701299.1| tetrahydrofolylpolyglutamate synth... 585 4e-165 gi|325048882|dbj|BAJ79308.1| putative FolC bifunctional protein ... 582 4e-164 gi|229493122|ref|ZP_04386914.1| FolC bifunctional protein [Rhodo... 578 6e-163 gi|296139192|ref|YP_003646435.1| FolC bifunctional protein [Tsuk... 578 9e-163 gi|226307286|ref|YP_002767246.1| folylpolyglutamate synthase [Rh... 577 1e-162 gi|262201991|ref|YP_003273199.1| FolC bifunctional protein [Gord... 575 4e-162 gi|334564151|ref|ZP_08517142.1| dihydrofolate synthase / folylpo... 573 2e-161 gi|343925348|ref|ZP_08764873.1| folylpolyglutamate synthase [Gor... 568 8e-160 gi|336325189|ref|YP_004605155.1| dihydrofolate synthase / folylp... 535 7e-150 gi|260578307|ref|ZP_05846223.1| tetrahydrofolate synthase [Coryn... 534 1e-149 gi|68535623|ref|YP_250328.1| dihydrofolate synthase / folylpolyg... 532 4e-149 gi|326382835|ref|ZP_08204525.1| FolC bifunctional protein [Gordo... 525 1e-146 gi|340793876|ref|YP_004759339.1| dihydrofolate synthase / folylp... 524 2e-146 gi|172041054|ref|YP_001800768.1| dihydrofolate synthase / folylp... 523 3e-146 gi|337291358|ref|YP_004630379.1| dihydrofolate synthase / folylp... 518 8e-145 gi|257055281|ref|YP_003133113.1| folylpolyglutamate synthase/dih... 516 3e-144 gi|334697408|gb|AEG82205.1| dihydrofolate synthase / folylpolygl... 516 4e-144 gi|225021675|ref|ZP_03710867.1| hypothetical protein CORMATOL_01... 510 2e-142 gi|213966174|ref|ZP_03394360.1| FolC bifunctional protein [Coryn... 508 9e-142 gi|305680780|ref|ZP_07403587.1| bifunctional protein FolC [Coryn... 506 3e-141 gi|256375307|ref|YP_003098967.1| FolC bifunctional protein [Acti... 504 1e-140 >gi|15609584|ref|NP_216963.1| folylpolyglutamate synthase protein FolC [Mycobacterium tuberculosis H37Rv] gi|15841971|ref|NP_337008.1| folylpolyglutamate synthase [Mycobacterium tuberculosis CDC1551] gi|31793628|ref|NP_856121.1| folylpolyglutamate synthase protein FolC [Mycobacterium bovis AF2122/97] 53 more sequence titles Length=487 Score = 962 bits (2487), Expect = 0.0, Method: Compositional matrix adjust. Identities = 487/487 (100%), Positives = 487/487 (100%), Gaps = 0/487 (0%) Query 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP Sbjct 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 Query 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY Sbjct 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 Query 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR Sbjct 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 Query 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK Sbjct 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 Query 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH Sbjct 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 Query 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS Sbjct 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 Query 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA Sbjct 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 Query 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART Sbjct 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 Query 481 LFGRDPQ 487 LFGRDPQ Sbjct 481 LFGRDPQ 487 >gi|254551497|ref|ZP_05141944.1| folylpolyglutamate synthase folC [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=487 Score = 961 bits (2483), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/487 (99%), Positives = 487/487 (100%), Gaps = 0/487 (0%) Query 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLT+ISALMDLLGSP Sbjct 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTQISALMDLLGSP 60 Query 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY Sbjct 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 Query 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR Sbjct 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 Query 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK Sbjct 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 Query 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH Sbjct 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 Query 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS Sbjct 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 Query 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA Sbjct 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 Query 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART Sbjct 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 Query 481 LFGRDPQ 487 LFGRDPQ Sbjct 481 LFGRDPQ 487 >gi|340627461|ref|YP_004745913.1| putative folylpolyglutamate synthase protein FOLC [Mycobacterium canettii CIPT 140010059] gi|340005651|emb|CCC44817.1| putative folylpolyglutamate synthase protein FOLC (folylpoly-gamma-glutamate synthetase) (FPGS) [Mycobacterium canettii CIPT 140010059] Length=487 Score = 960 bits (2482), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/487 (99%), Positives = 486/487 (99%), Gaps = 0/487 (0%) Query 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP Sbjct 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 Query 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY Sbjct 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 Query 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 VATYREIEPLV LIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR Sbjct 121 VATYREIEPLVQLIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 Query 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK Sbjct 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 Query 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH Sbjct 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 Query 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS Sbjct 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 Query 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA Sbjct 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 Query 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART Sbjct 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 Query 481 LFGRDPQ 487 LFGRDPQ Sbjct 481 LFGRDPQ 487 >gi|344220276|gb|AEN00907.1| folylpolyglutamate synthase protein FolC [Mycobacterium tuberculosis CTRI-2] Length=487 Score = 960 bits (2482), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/487 (99%), Positives = 486/487 (99%), Gaps = 0/487 (0%) Query 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP Sbjct 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 Query 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY Sbjct 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 Query 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR Sbjct 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 Query 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK Sbjct 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 Query 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH Sbjct 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 Query 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS Sbjct 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 Query 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALAL Sbjct 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALV 420 Query 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART Sbjct 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 Query 481 LFGRDPQ 487 LFGRDPQ Sbjct 481 LFGRDPQ 487 >gi|298525926|ref|ZP_07013335.1| folylpolyglutamate synthase protein folC [Mycobacterium tuberculosis 94_M4241A] gi|298495720|gb|EFI31014.1| folylpolyglutamate synthase protein folC [Mycobacterium tuberculosis 94_M4241A] Length=487 Score = 959 bits (2479), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/487 (99%), Positives = 486/487 (99%), Gaps = 0/487 (0%) Query 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP Sbjct 1 MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP 60 Query 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY Sbjct 61 QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY 120 Query 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR Sbjct 121 VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR 180 Query 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK Sbjct 181 WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK 240 Query 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH Sbjct 241 VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH 300 Query 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS 360 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPT FIDAAHNPAGAS Sbjct 301 NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTGFIDAAHNPAGAS 360 Query 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA Sbjct 361 ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA 420 Query 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART Sbjct 421 AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART 480 Query 481 LFGRDPQ 487 LFGRDPQ Sbjct 481 LFGRDPQ 487 >gi|193506586|pdb|2VOS|A Chain A, Mycobacterium Tuberculosis Folylpolyglutamate Synthase Complexed With Adp Length=487 Score = 941 bits (2431), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/486 (99%), Positives = 479/486 (99%), Gaps = 0/486 (0%) Query 2 NSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQ 61 NSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISAL DLLGSPQ Sbjct 2 NSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALXDLLGSPQ 61 Query 62 RSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYV 121 RSYPSIHIAGTNGKTSVAR VDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYV Sbjct 62 RSYPSIHIAGTNGKTSVARXVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYV 121 Query 122 ATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRW 181 ATYREIEPLVALIDQQSQASAGKGGPA SKFEVLTA AFAAFADAPVDVAVVEVG GGRW Sbjct 122 ATYREIEPLVALIDQQSQASAGKGGPAXSKFEVLTAXAFAAFADAPVDVAVVEVGXGGRW 181 Query 182 DATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKV 241 DATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKV Sbjct 182 DATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKV 241 Query 242 MEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHN 301 EVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHN Sbjct 242 XEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHN 301 Query 302 AVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASA 361 AVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLER RSAPTVFIDAAHNPAGASA Sbjct 302 AVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERXRSAPTVFIDAAHNPAGASA 361 Query 362 LAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAA 421 LAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAA Sbjct 362 LAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAA 421 Query 422 GERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTL 481 GERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTL Sbjct 422 GERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTL 481 Query 482 FGRDPQ 487 FGRDPQ Sbjct 482 FGRDPQ 487 >gi|308232135|ref|ZP_07415055.2| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu001] gi|308369722|ref|ZP_07418829.2| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu002] gi|308371017|ref|ZP_07423566.2| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu003] 15 more sequence titles Length=470 Score = 927 bits (2395), Expect = 0.0, Method: Compositional matrix adjust. Identities = 469/470 (99%), Positives = 470/470 (100%), Gaps = 0/470 (0%) Query 18 VPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTS 77 +PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTS Sbjct 1 MPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTS 60 Query 78 VARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQ 137 VARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQ Sbjct 61 VARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQ 120 Query 138 SQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPI 197 SQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPI Sbjct 121 SQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPI 180 Query 198 SIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVA 257 SIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVA Sbjct 181 SIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVA 240 Query 258 REDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGA 317 REDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGA Sbjct 241 REDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGA 300 Query 318 QRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVG 377 QRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVG Sbjct 301 QRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVG 360 Query 378 VLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLR 437 VLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLR Sbjct 361 VLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLR 420 Query 438 DAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 DAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ Sbjct 421 DAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 470 >gi|308375894|ref|ZP_07445438.2| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu007] gi|308377013|ref|ZP_07440867.2| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu008] gi|308344877|gb|EFP33728.1| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu007] gi|308349187|gb|EFP38038.1| folylpolyglutamate synthase folC [Mycobacterium tuberculosis SUMu008] Length=434 Score = 854 bits (2207), Expect = 0.0, Method: Compositional matrix adjust. Identities = 434/434 (100%), Positives = 434/434 (100%), Gaps = 0/434 (0%) Query 54 MDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGK 113 MDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGK Sbjct 1 MDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGK 60 Query 114 PISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVV 173 PISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVV Sbjct 61 PISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVV 120 Query 174 EVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAV 233 EVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAV Sbjct 121 EVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAV 180 Query 234 IGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPL 293 IGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPL Sbjct 181 IGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPL 240 Query 294 HGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAA 353 HGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAA Sbjct 241 HGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAA 300 Query 354 HNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALD 413 HNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALD Sbjct 301 HNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALD 360 Query 414 VEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVV 473 VEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVV Sbjct 361 VEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVV 420 Query 474 TAGAARTLFGRDPQ 487 TAGAARTLFGRDPQ Sbjct 421 TAGAARTLFGRDPQ 434 >gi|342857845|ref|ZP_08714501.1| folylpolyglutamate synthase protein FolC [Mycobacterium colombiense CECT 3035] gi|342135178|gb|EGT88344.1| folylpolyglutamate synthase protein FolC [Mycobacterium colombiense CECT 3035] Length=494 Score = 755 bits (1950), Expect = 0.0, Method: Compositional matrix adjust. Identities = 407/471 (87%), Positives = 441/471 (94%), Gaps = 5/471 (1%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 PTPDEIASLLQVEHLLDQRWPET+I+PSLTRISALMDLLGSPQ +YPSIH+AGTNGKTSV Sbjct 27 PTPDEIASLLQVEHLLDQRWPETKIEPSLTRISALMDLLGSPQLAYPSIHVAGTNGKTSV 86 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 ARM+DAL+TALHRRTGRTTSPHLQS +ERISID KPISPAQYVATYREIEP V ++D QS Sbjct 87 ARMIDALITALHRRTGRTTSPHLQSAIERISIDSKPISPAQYVATYREIEPFVQMVDAQS 146 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 QA GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS Sbjct 147 QAD---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 203 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAR 258 IDHV+YLG D+A IAGEKAGIITRAP+G+PDTVAVIGRQ P+ MEVLL+++VRADA+VAR Sbjct 204 IDHVEYLGDDLAAIAGEKAGIITRAPEGAPDTVAVIGRQAPEAMEVLLSQTVRADAAVAR 263 Query 259 EDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQ 318 EDSEFAVL RQ+A+GGQVLQLQGLGGVYSD+YLPLHGEHQAHNA LALA+VEAFFGAGAQ Sbjct 264 EDSEFAVLGRQVAIGGQVLQLQGLGGVYSDVYLPLHGEHQAHNAALALAAVEAFFGAGAQ 323 Query 319 RQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGV 378 RQLD +AVRAGFAAV SPGRLERMRSAPTVF+DAAHNPAGA+ALA+TLA EFDFR+LVGV Sbjct 324 RQLDVEAVRAGFAAVASPGRLERMRSAPTVFLDAAHNPAGAAALARTLADEFDFRYLVGV 383 Query 379 LSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRD 438 LSVL DKDVDGILAAL+PVFD+VVVTHNGSPRALDVE+LALAA ERFGPDRV TAENLRD Sbjct 384 LSVLADKDVDGILAALQPVFDAVVVTHNGSPRALDVESLALAARERFGPDRVSTAENLRD 443 Query 439 AIDVATSLVDDAAAD--PDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 AIDVAT+LVDDA D D + +AFS TGIV+TGSVVTAGAARTLFGRDPQ Sbjct 444 AIDVATALVDDAGRDGVADGSAEAFSGTGIVVTGSVVTAGAARTLFGRDPQ 494 >gi|254821842|ref|ZP_05226843.1| FolC protein [Mycobacterium intracellulare ATCC 13950] Length=489 Score = 746 bits (1926), Expect = 0.0, Method: Compositional matrix adjust. Identities = 403/471 (86%), Positives = 436/471 (93%), Gaps = 5/471 (1%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 PTPDEIA+LLQVEHLLDQRWPET+I+PSLTRISALMDLLGSPQ +YPSIH+AGTNGKTSV Sbjct 22 PTPDEIAALLQVEHLLDQRWPETKIEPSLTRISALMDLLGSPQLAYPSIHVAGTNGKTSV 81 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 ARM+DAL+TALHRRTGRTTSPHLQS VERISID KPISPAQYVATYREIEP V ++D QS Sbjct 82 ARMIDALITALHRRTGRTTSPHLQSAVERISIDAKPISPAQYVATYREIEPFVQMVDAQS 141 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 QA+ GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVA ITPI+ Sbjct 142 QAA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAAITPIA 198 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAR 258 +DHVDYLG D+AGIAGEKAGIITRAP+G+PDTVAVI RQ P+ MEVLLA++V+ADA+VAR Sbjct 199 LDHVDYLGDDLAGIAGEKAGIITRAPEGAPDTVAVIARQAPEAMEVLLAQTVQADAAVAR 258 Query 259 EDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQ 318 EDSEFAVL RQ+A+GGQVLQLQGLGGVYSD+YLPLHGEHQAHNA LALA+VEAFFGAGAQ Sbjct 259 EDSEFAVLGRQVAIGGQVLQLQGLGGVYSDVYLPLHGEHQAHNAALALAAVEAFFGAGAQ 318 Query 319 RQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGV 378 RQLD +AVRAGFAAV SPGRLERMRSAPTVFIDAAHNPAGA+ALAQTLA EFDFR+LVGV Sbjct 319 RQLDVEAVRAGFAAVVSPGRLERMRSAPTVFIDAAHNPAGAAALAQTLAGEFDFRYLVGV 378 Query 379 LSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRD 438 LSVL DKDVDGILAAL+PVFD+VVVTHNGSPRA+DVE+LALAA E FGPDRV TAENLRD Sbjct 379 LSVLADKDVDGILAALQPVFDAVVVTHNGSPRAVDVESLALAARETFGPDRVSTAENLRD 438 Query 439 AIDVATSLVDDAAADPDVAGDA--FSRTGIVITGSVVTAGAARTLFGRDPQ 487 AIDVAT+LVD + G A FS TGIVITGSVVTAGAARTLFGRDPQ Sbjct 439 AIDVATALVDSEVEGAALDGHAEDFSGTGIVITGSVVTAGAARTLFGRDPQ 489 >gi|296170486|ref|ZP_06852073.1| tetrahydrofolate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894838|gb|EFG74560.1| tetrahydrofolate synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=485 Score = 741 bits (1914), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/477 (84%), Positives = 437/477 (92%), Gaps = 5/477 (1%) Query 11 SGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIA 70 +G A + PTPDEIASLLQVEHLLDQRWPET+I+PSLTRISALMDLLGSPQ +YP IHIA Sbjct 14 NGEAVSLAPTPDEIASLLQVEHLLDQRWPETKIEPSLTRISALMDLLGSPQLAYPCIHIA 73 Query 71 GTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPL 130 GTNGKTSVARMVDALVTALHRRTGRTTSPHLQS VERI+IDG+PISPAQYVATYREIEP Sbjct 74 GTNGKTSVARMVDALVTALHRRTGRTTSPHLQSAVERIAIDGRPISPAQYVATYREIEPF 133 Query 131 VALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAP 190 V +ID QSQ + GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNV+NAP Sbjct 134 VQMIDAQSQDA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVVNAP 190 Query 191 VAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESV 250 VAVITP+ IDHV+YLG D+ IAGEKAGIIT+A +G+PDTVAVI RQ P+ M VLLA++V Sbjct 191 VAVITPVGIDHVEYLGDDLPAIAGEKAGIITKAAEGAPDTVAVIARQAPEAMGVLLAQTV 250 Query 251 RADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVE 310 RADA+VAREDSEFAVL RQ+A+GGQVL+LQGLGGVYSDIYLPLHGEHQAHNAV+ALA+VE Sbjct 251 RADAAVAREDSEFAVLGRQVAIGGQVLELQGLGGVYSDIYLPLHGEHQAHNAVVALAAVE 310 Query 311 AFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEF 370 AFFGAGAQRQLD +AVRAGFA+VTSPGRLERMRSAPTVFIDAAHNP GA+ALAQTL+ EF Sbjct 311 AFFGAGAQRQLDVEAVRAGFASVTSPGRLERMRSAPTVFIDAAHNPGGAAALAQTLSDEF 370 Query 371 DFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRV 430 DFR+LVGVLSVL DKD +GILAALEPV D+VVVTHNGSPRALDV +LALAA ERFGPDRV Sbjct 371 DFRYLVGVLSVLADKDANGILAALEPVLDAVVVTHNGSPRALDVGSLALAAEERFGPDRV 430 Query 431 RTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 +A+NLRDAID AT+LVDDAA + + +AFS TGIVITGSVVTAGAARTLFGRDP+ Sbjct 431 ISADNLRDAIDAATALVDDAALEGE--AEAFSGTGIVITGSVVTAGAARTLFGRDPE 485 >gi|15827773|ref|NP_302036.1| folylpolyglutamate synthase [Mycobacterium leprae TN] gi|221230250|ref|YP_002503666.1| folylpolyglutamate synthase [Mycobacterium leprae Br4923] gi|13093325|emb|CAC30421.1| folylpolyglutamate synthase [Mycobacterium leprae] gi|219933357|emb|CAR71565.1| folylpolyglutamate synthase [Mycobacterium leprae Br4923] Length=485 Score = 728 bits (1880), Expect = 0.0, Method: Compositional matrix adjust. Identities = 380/483 (79%), Positives = 424/483 (88%), Gaps = 7/483 (1%) Query 9 PDSGSA---TGVVP-TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 PD GS T V TPD++ASLLQVEHLLDQRWPET I+PSLTRISALMD+LGSPQ SY Sbjct 6 PDWGSGRLETNVAALTPDKVASLLQVEHLLDQRWPETCIEPSLTRISALMDVLGSPQLSY 65 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PSIH+AGTNGKTSV RMVDAL+TALH+RTGR TSPHLQS VERI+ID KPISPAQYVATY Sbjct 66 PSIHVAGTNGKTSVTRMVDALLTALHQRTGRFTSPHLQSVVERIAIDSKPISPAQYVATY 125 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 RE+EP V +ID QSQ+S GGPA+SKFEV+TAMAFAAFA+APVD+AVVEVG+GGRWDAT Sbjct 126 REVEPFVQMIDAQSQSS---GGPALSKFEVVTAMAFAAFANAPVDIAVVEVGLGGRWDAT 182 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEV 244 NVINA VAVITP+SIDHV+YLG D+A IA EKAGIIT+AP+G+PDTV VIGRQVP M V Sbjct 183 NVINASVAVITPVSIDHVEYLGNDVAAIAREKAGIITKAPEGAPDTVVVIGRQVPAAMGV 242 Query 245 LLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVL 304 LLA+S A A V R+DSEFAVL RQ+A+GGQVLQLQGLGGVY+DIYLPLHGEHQAHNAVL Sbjct 243 LLAQSAHAGARVVRQDSEFAVLDRQVAIGGQVLQLQGLGGVYNDIYLPLHGEHQAHNAVL 302 Query 305 ALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQ 364 LA+VEAF+GAG QRQLD +AVR+GFAAV SPGRLERMRSAPTVFIDAAHNPAGA+ALA+ Sbjct 303 VLAAVEAFYGAGVQRQLDVEAVRSGFAAVISPGRLERMRSAPTVFIDAAHNPAGANALAR 362 Query 365 TLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGER 424 TL+ EF+FR LVGVLSVL +KDVDGILAALE V D +VVT NGSPRALDVE+LAL A ER Sbjct 363 TLSDEFNFRTLVGVLSVLANKDVDGILAALELVLDYIVVTDNGSPRALDVESLALVARER 422 Query 425 FGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGR 484 FGPDRV +A NLRDAID AT+LVDDAAA+ ++ G S GIVITGSV+TAG ARTLFGR Sbjct 423 FGPDRVISAANLRDAIDAATALVDDAAANEEIEGLGVSGRGIVITGSVITAGIARTLFGR 482 Query 485 DPQ 487 DPQ Sbjct 483 DPQ 485 >gi|41408368|ref|NP_961204.1| hypothetical protein MAP2270c [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396724|gb|AAS04587.1| FolC [Mycobacterium avium subsp. paratuberculosis K-10] Length=485 Score = 721 bits (1860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 413/487 (85%), Positives = 444/487 (92%), Gaps = 8/487 (1%) Query 6 SGPPDSGSATGV---VPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQR 62 S PPD V VPTPDEIA+LLQVEHLLDQRWPET+I+PSLTRISAL+DLLGSPQR Sbjct 2 SEPPDWAPEHDVPDPVPTPDEIAALLQVEHLLDQRWPETKIEPSLTRISALLDLLGSPQR 61 Query 63 SYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVA 122 +YPSIH+AGTNGKTSVARM+DALVTALHRRTGRTTSPHLQS VERISID KPISPA+YV Sbjct 62 AYPSIHVAGTNGKTSVARMIDALVTALHRRTGRTTSPHLQSAVERISIDAKPISPARYVD 121 Query 123 TYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWD 182 TYREIEP V ++DQQSQA+ GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWD Sbjct 122 TYREIEPFVQMVDQQSQAA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWD 178 Query 183 ATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVM 242 ATNV+NAPVAVITPISIDHVDYLG D+AGIAGEKAGIITRAP G+PDTVAVI +Q P+VM Sbjct 179 ATNVVNAPVAVITPISIDHVDYLGHDLAGIAGEKAGIITRAPAGAPDTVAVIAQQPPEVM 238 Query 243 EVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNA 302 EVLLA+ V+ADA+VAR SEFAVL RQ+A+GGQ+LQLQGLGGVYSD+YLPLHGEHQAHNA Sbjct 239 EVLLAQCVQADAAVARAGSEFAVLGRQVAIGGQLLQLQGLGGVYSDVYLPLHGEHQAHNA 298 Query 303 VLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASAL 362 LALA+VEAFFGAGAQRQLD DAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGA+AL Sbjct 299 ALALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAAAL 358 Query 363 AQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAG 422 A+TLA EFDFRFLVGVLSVL DKDVDGILAAL+PVF SVVVTHNGSPRALDVE+LALAA Sbjct 359 ARTLADEFDFRFLVGVLSVLADKDVDGILAALQPVFHSVVVTHNGSPRALDVESLALAAR 418 Query 423 ERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDA--FSRTGIVITGSVVTAGAART 480 E+FGPDRV TAENL DAIDVAT+LVDDA D V G A F+ TGIVITGSVVTAGAART Sbjct 419 EQFGPDRVSTAENLSDAIDVATALVDDAVRDGLVDGQAEDFAGTGIVITGSVVTAGAART 478 Query 481 LFGRDPQ 487 LFGRDPQ Sbjct 479 LFGRDPQ 485 >gi|118464061|ref|YP_880952.1| FolC protein [Mycobacterium avium 104] gi|118165348|gb|ABK66245.1| FolC protein [Mycobacterium avium 104] gi|336458194|gb|EGO37175.1| folylpolyglutamate synthase/dihydrofolate synthase [Mycobacterium avium subsp. paratuberculosis S397] Length=485 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 412/485 (85%), Positives = 443/485 (92%), Gaps = 8/485 (1%) Query 8 PPDSGSATGV---VPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 PPD V VPTPDEIA+LLQVEHLLDQRWPET+I+PSLTRISAL+DLLGSPQR+Y Sbjct 4 PPDWAPEHDVPDPVPTPDEIAALLQVEHLLDQRWPETKIEPSLTRISALLDLLGSPQRAY 63 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PSIH+AGTNGKTSVARM+DALVTALHRRTGRTTSPHLQS VERISID KPISPA+YV TY Sbjct 64 PSIHVAGTNGKTSVARMIDALVTALHRRTGRTTSPHLQSAVERISIDAKPISPARYVDTY 123 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V ++DQQSQA+ GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT Sbjct 124 REIEPFVQMVDQQSQAA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 180 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEV 244 NV+NAPVAVITPISIDHVDYLG D+AGIAGEKAGIITRAP G+PDTVAVI +Q P+VMEV Sbjct 181 NVVNAPVAVITPISIDHVDYLGHDLAGIAGEKAGIITRAPAGAPDTVAVIAQQPPEVMEV 240 Query 245 LLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVL 304 LLA+ V+ADA+VAR SEFAVL RQ+A+GGQ+LQLQGLGGVYSD+YLPLHGEHQAHNA L Sbjct 241 LLAQCVQADAAVARAGSEFAVLGRQVAIGGQLLQLQGLGGVYSDVYLPLHGEHQAHNAAL 300 Query 305 ALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQ 364 ALA+VEAFFGAGAQRQLD DAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGA+ALA+ Sbjct 301 ALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAAALAR 360 Query 365 TLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGER 424 TLA EFDFRFLVGVLSVL DKDVDGILAAL+PVF SVVVTHNGSPRALDVE+LALAA E+ Sbjct 361 TLADEFDFRFLVGVLSVLADKDVDGILAALQPVFHSVVVTHNGSPRALDVESLALAAREQ 420 Query 425 FGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDA--FSRTGIVITGSVVTAGAARTLF 482 FGPDRV TAENL DAIDVAT+LVDDA D V G A F+ TGIVITGSVVTAGAARTLF Sbjct 421 FGPDRVSTAENLSDAIDVATALVDDAVRDGLVDGQAEDFAGTGIVITGSVVTAGAARTLF 480 Query 483 GRDPQ 487 GRDPQ Sbjct 481 GRDPQ 485 >gi|254774540|ref|ZP_05216056.1| FolC protein [Mycobacterium avium subsp. avium ATCC 25291] Length=485 Score = 716 bits (1849), Expect = 0.0, Method: Compositional matrix adjust. Identities = 410/485 (85%), Positives = 441/485 (91%), Gaps = 8/485 (1%) Query 8 PPDSGSATGV---VPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 PPD V VPTPDEIA+LLQVEHLLDQRWPET+I+PSLTRISAL+DLLGSPQR+Y Sbjct 4 PPDWAPEHDVPDPVPTPDEIAALLQVEHLLDQRWPETKIEPSLTRISALLDLLGSPQRAY 63 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PSIH+AGTNGKTSVARM+DALVTALHRRTGRTTSPHLQS VERISID KPISPA+YV TY Sbjct 64 PSIHVAGTNGKTSVARMIDALVTALHRRTGRTTSPHLQSAVERISIDAKPISPARYVDTY 123 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V ++DQQSQA+ GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT Sbjct 124 REIEPFVQMVDQQSQAA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 180 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEV 244 NV+NAPVAVITPISIDHVDYLG D+AGIAGEKAGIITRAP G+PDTVAVI +Q P+VMEV Sbjct 181 NVVNAPVAVITPISIDHVDYLGHDLAGIAGEKAGIITRAPAGAPDTVAVIAQQPPEVMEV 240 Query 245 LLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVL 304 LLA+ V+ADA+VAR SEFAVL RQ+A+GGQ+LQLQGLGGVYSD+YLPLHGEHQ HNA L Sbjct 241 LLAQCVQADAAVARAGSEFAVLGRQVAIGGQLLQLQGLGGVYSDVYLPLHGEHQVHNAAL 300 Query 305 ALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQ 364 ALA+VEAFFGAGAQRQLD DAVRAGFAAVTSPGRLERMR APTVFIDAAHNPAGA+ALA+ Sbjct 301 ALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRLERMRRAPTVFIDAAHNPAGAAALAR 360 Query 365 TLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGER 424 TLA EFDFRFLVGVLSVL DKDVDGILAAL+PVF SVVVTHNGSPRALDVE+LALAA E+ Sbjct 361 TLADEFDFRFLVGVLSVLADKDVDGILAALQPVFHSVVVTHNGSPRALDVESLALAAREQ 420 Query 425 FGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDA--FSRTGIVITGSVVTAGAARTLF 482 FGPDRV TAENL DAIDVAT+LVDDA D V G A F+ TGIVITGSVVTAGAARTLF Sbjct 421 FGPDRVSTAENLSDAIDVATALVDDAVRDGLVDGQAEDFAGTGIVITGSVVTAGAARTLF 480 Query 483 GRDPQ 487 GRDPQ Sbjct 481 GRDPQ 485 >gi|333990100|ref|YP_004522714.1| folylpolyglutamate synthase protein FolC [Mycobacterium sp. JDM601] gi|333486068|gb|AEF35460.1| folylpolyglutamate synthase protein FolC [Mycobacterium sp. JDM601] Length=470 Score = 703 bits (1815), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/471 (78%), Positives = 402/471 (86%), Gaps = 8/471 (1%) Query 16 GVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGK 75 G PTPDEIA+LLQVEHLLDQRW ET+I PSLTRI+AL++LLGSPQR YPSIH+AGTNGK Sbjct 7 GAEPTPDEIAALLQVEHLLDQRWGETKIQPSLTRINALLELLGSPQRGYPSIHVAGTNGK 66 Query 76 TSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALID 135 TSV RM+DAL+TA RRTGRTTSPHLQS VERI IDG PISPA+YV TY EIEP V ++D Sbjct 67 TSVVRMIDALLTAFSRRTGRTTSPHLQSAVERIGIDGVPISPAKYVETYAEIEPFVHMVD 126 Query 136 QQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVIT 195 SQA + GPAMSKFEVLT MAFAAFADAPVDVAVVEVGMGGRWDATNV+ APVAVIT Sbjct 127 ASSQA---ENGPAMSKFEVLTGMAFAAFADAPVDVAVVEVGMGGRWDATNVVGAPVAVIT 183 Query 196 PISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADAS 255 PI +DHVDYLG DIAGIA EKAGII R+ D DTVAVI RQ P+VMEVLL +SVRADA+ Sbjct 184 PIGVDHVDYLGDDIAGIAAEKAGIIHRSSDELTDTVAVIARQAPEVMEVLLTQSVRADAA 243 Query 256 VAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGA 315 VARE+SEFAV RQ+A+GGQ+L+LQGLGGVYSDI+LPLHGEHQAHNAVLALA+VEAFFGA Sbjct 244 VARENSEFAVRSRQLAIGGQLLELQGLGGVYSDIFLPLHGEHQAHNAVLALAAVEAFFGA 303 Query 316 GAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFL 375 GA+RQLD D VRAGFAAV SPGRLERMRS+PTVFIDAAHNPAGA+ LAQ L +F FRFL Sbjct 304 GAERQLDADTVRAGFAAVRSPGRLERMRSSPTVFIDAAHNPAGAAVLAQALTEDFGFRFL 363 Query 376 VGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAEN 435 VGV+SVLGDKD DGILAALEPVFD +VVTHNGSPRA+DVE L A FG DRV T + Sbjct 364 VGVVSVLGDKDADGILAALEPVFDRIVVTHNGSPRAVDVETLTAVAVRWFGEDRVVTTDT 423 Query 436 LRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 L DAID AT+LVD+ +D D G TGIVITGSVVTAGAARTLFG+DP Sbjct 424 LEDAIDTATALVDEFDSDGDTTG-----TGIVITGSVVTAGAARTLFGKDP 469 >gi|240170919|ref|ZP_04749578.1| folylpolyglutamate synthase protein FolC [Mycobacterium kansasii ATCC 12478] Length=480 Score = 703 bits (1814), Expect = 0.0, Method: Compositional matrix adjust. Identities = 406/474 (86%), Positives = 437/474 (93%), Gaps = 3/474 (0%) Query 14 ATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTN 73 +TG+ PTPDEIASLLQVEHLLDQRWPETRI+PSLTRISAL+DLLGSPQ SYPSIHIAGTN Sbjct 10 STGMAPTPDEIASLLQVEHLLDQRWPETRIEPSLTRISALLDLLGSPQLSYPSIHIAGTN 69 Query 74 GKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVAL 133 GKTSVARMVDALVTALH+RTGRTTSPHLQS VERISIDGKPISPAQYVATYREIEP V + Sbjct 70 GKTSVARMVDALVTALHQRTGRTTSPHLQSVVERISIDGKPISPAQYVATYREIEPFVQM 129 Query 134 IDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAV 193 ID+QSQ + GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAV Sbjct 130 IDEQSQNA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAV 186 Query 194 ITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRAD 253 ITPIS DHVDYLG DIAGIAGEKAGII +A +GSPDTVAVI RQ P+VMEVLL ++VRAD Sbjct 187 ITPISKDHVDYLGDDIAGIAGEKAGIIHQAAEGSPDTVAVIARQRPEVMEVLLGQAVRAD 246 Query 254 ASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFF 313 A+VARE+SEFAVL RQ+AVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAV+ALA+VEAFF Sbjct 247 AAVAREESEFAVLGRQVAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVVALAAVEAFF 306 Query 314 GAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFR 373 GAGAQRQLD +AVRAGFAA TSPGRLERMRSAPTVFIDAAHNPAGA+ALA+TLA EFDFR Sbjct 307 GAGAQRQLDVEAVRAGFAAATSPGRLERMRSAPTVFIDAAHNPAGAAALARTLAAEFDFR 366 Query 374 FLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTA 433 LVGV+SVL DKDVDGIL A+EPVFDSVVVTHNGSPRALDVE+LA AA ERFGPDRV +A Sbjct 367 TLVGVVSVLADKDVDGILQAVEPVFDSVVVTHNGSPRALDVESLAAAARERFGPDRVLSA 426 Query 434 ENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 NL DAID AT+LVD+AAA G +F +GIV+TGSVVTAGAARTLFGR+PQ Sbjct 427 ANLSDAIDTATALVDEAAAQQGAEGGSFPGSGIVVTGSVVTAGAARTLFGRNPQ 480 >gi|183983751|ref|YP_001852042.1| folylpolyglutamate synthase protein FolC [Mycobacterium marinum M] gi|183177077|gb|ACC42187.1| folylpolyglutamate synthase protein FolC [Mycobacterium marinum M] Length=484 Score = 683 bits (1763), Expect = 0.0, Method: Compositional matrix adjust. Identities = 407/483 (85%), Positives = 443/483 (92%), Gaps = 6/483 (1%) Query 8 PPD-SGSATG--VVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 PPD +G A G PTPDE+ASLLQVEHLLDQRWPETRI+PSLTRISALMDLLGSPQ SY Sbjct 5 PPDWTGLAQGSDAEPTPDELASLLQVEHLLDQRWPETRIEPSLTRISALMDLLGSPQLSY 64 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PSIHI GTNGKTSVARMVDAL+TALH+RTGRTTSPHLQS VERISIDGKPI+PAQYV TY Sbjct 65 PSIHIGGTNGKTSVARMVDALITALHQRTGRTTSPHLQSAVERISIDGKPITPAQYVQTY 124 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V +IDQQSQA+ GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVG+GGRWDAT Sbjct 125 REIEPFVQMIDQQSQAA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGLGGRWDAT 181 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEV 244 NVINAPVAVITPISIDHVDYLG DIA IAGEKAGII +A DGSPDTVAVIGRQ+P+ MEV Sbjct 182 NVINAPVAVITPISIDHVDYLGDDIASIAGEKAGIIHKAADGSPDTVAVIGRQLPEAMEV 241 Query 245 LLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVL 304 LLA++VRADA+VAREDSEFAVL RQ+AVGGQ+LQLQGLGGVYSDIYLPLHGEHQAHNAV+ Sbjct 242 LLAQAVRADAAVAREDSEFAVLGRQVAVGGQLLQLQGLGGVYSDIYLPLHGEHQAHNAVV 301 Query 305 ALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQ 364 ALA+VEAFFGAGAQRQLD DAVRAGFAAVTSPGRLER+RS+PTVFIDAAHNPAGA+ALAQ Sbjct 302 ALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRLERLRSSPTVFIDAAHNPAGAAALAQ 361 Query 365 TLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGER 424 +L EFDFR LVGV++V+ DKDV+GILAALEP FDS+VVTHNGSPRALDV +LALAA + Sbjct 362 SLVAEFDFRSLVGVIAVMADKDVNGILAALEPAFDSIVVTHNGSPRALDVASLALAAEQY 421 Query 425 FGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGR 484 FGPDRV TAENLRDA+D AT+LVD++A D + G + S TGIVITGSVVTAGAARTLFGR Sbjct 422 FGPDRVITAENLRDAVDAATALVDESAIDWEAQGGSLSGTGIVITGSVVTAGAARTLFGR 481 Query 485 DPQ 487 DPQ Sbjct 482 DPQ 484 >gi|118618979|ref|YP_907311.1| folylpolyglutamate synthase protein FolC [Mycobacterium ulcerans Agy99] gi|118571089|gb|ABL05840.1| folylpolyglutamate synthase protein FolC [Mycobacterium ulcerans Agy99] Length=484 Score = 679 bits (1752), Expect = 0.0, Method: Compositional matrix adjust. Identities = 405/483 (84%), Positives = 441/483 (92%), Gaps = 6/483 (1%) Query 8 PPD-SGSATG--VVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 PPD +G A G PTPDE+ASLLQVEHLLDQRWPETRI+PSLTRISALMDLLGSPQ SY Sbjct 5 PPDWTGLAQGSDAEPTPDELASLLQVEHLLDQRWPETRIEPSLTRISALMDLLGSPQLSY 64 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PSIHI GTNGKTSVARM DAL+TALH+RTGRTTSPHLQS VERISIDGKPI+PAQYV TY Sbjct 65 PSIHIGGTNGKTSVARMFDALITALHQRTGRTTSPHLQSAVERISIDGKPITPAQYVQTY 124 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V +IDQQSQA+ GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVG+GGRWDAT Sbjct 125 REIEPFVQMIDQQSQAA---GGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGLGGRWDAT 181 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEV 244 NVINAPVAVITPISIDHVDYLG DIA IAGEKAGII +A DGSPDTVAVIGRQ+P+ MEV Sbjct 182 NVINAPVAVITPISIDHVDYLGDDIASIAGEKAGIIHKAADGSPDTVAVIGRQLPEAMEV 241 Query 245 LLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVL 304 LLA++VRADA+VAREDSEFAVL RQ+AVGGQ+LQLQGLGGVYSDIYLPLHGEHQAHNAV+ Sbjct 242 LLAQAVRADAAVAREDSEFAVLGRQVAVGGQLLQLQGLGGVYSDIYLPLHGEHQAHNAVV 301 Query 305 ALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQ 364 ALA+VEAFFGAGAQRQLD DAVRAGFAAVTSPGRLER+RS+PTVFIDAAHNPAGA+ALAQ Sbjct 302 ALAAVEAFFGAGAQRQLDVDAVRAGFAAVTSPGRLERLRSSPTVFIDAAHNPAGAAALAQ 361 Query 365 TLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGER 424 +L EFDFR LVGV++V+ DKDV+GILAALEP FDS+VVTHNGSPRALDV +LALAA + Sbjct 362 SLVAEFDFRSLVGVVAVMADKDVNGILAALEPAFDSIVVTHNGSPRALDVASLALAAEQY 421 Query 425 FGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGR 484 FGPDRV TAENLRDA+D AT+LVD++A D + G + S TGIVITGSVVTAGAA TLFGR Sbjct 422 FGPDRVITAENLRDAVDAATALVDESAIDWEAQGGSLSGTGIVITGSVVTAGAAHTLFGR 481 Query 485 DPQ 487 DPQ Sbjct 482 DPQ 484 >gi|169628694|ref|YP_001702343.1| folylpolyglutamate synthase FolC [Mycobacterium abscessus ATCC 19977] gi|169240661|emb|CAM61689.1| Probable folylpolyglutamate synthase FolC [Mycobacterium abscessus] Length=478 Score = 659 bits (1701), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/475 (72%), Positives = 400/475 (85%), Gaps = 11/475 (2%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 P+PDEIA+LLQ+E+LLDQRWPET+I+PS RI ALM+LLGSPQR+YP IH+AGTNGKTSV Sbjct 9 PSPDEIAALLQIEYLLDQRWPETKIEPSTDRIVALMELLGSPQRAYPCIHVAGTNGKTSV 68 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 RM+DAL+TALHRRTGRTTSPHLQS VERI+IDG+PISPA+YV Y EIEP V L+D+QS Sbjct 69 TRMIDALLTALHRRTGRTTSPHLQSAVERIAIDGQPISPAKYVEIYSEIEPFVELVDKQS 128 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 Q +GGPAMSKFEVL AMAF AFADAPVD+AVVEVG+GGRWDATN+I+APVAV+TPI Sbjct 129 QE---QGGPAMSKFEVLVAMAFVAFADAPVDIAVVEVGLGGRWDATNIIDAPVAVVTPIG 185 Query 199 IDHVDYLGADIAGIAGEKAGIITRAP------DGSPDTVAVIGRQVPKVMEVLLAESVRA 252 IDHV++LG D+A IA EKAGII R + DTVAVI +Q P+ MEVLL ++V A Sbjct 186 IDHVEFLGPDLASIANEKAGIIKRHKLDAMTGEAGADTVAVIAQQQPEAMEVLLRQTVEA 245 Query 253 DASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAF 312 DA+VARE SEFAVL RQ+AVGGQ+L+LQGLGGVY +I+LPLHGEHQAHNA +ALA+VEAF Sbjct 246 DAAVAREGSEFAVLSRQVAVGGQLLELQGLGGVYPEIFLPLHGEHQAHNAAVALAAVEAF 305 Query 313 FGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDF 372 FGAGA RQLD +A+R+GFA+V PGRLER+RSAP VF+DAAHNP GA+ALA+TL EFDF Sbjct 306 FGAGADRQLDIEAIRSGFASVIIPGRLERVRSAPAVFLDAAHNPHGAAALAETLQSEFDF 365 Query 373 RFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRT 432 R LVGV+SV+GDKDV GIL ALEP FD +VVTHNGSPRA++ +ALA A E FG DRV Sbjct 366 RRLVGVISVMGDKDVAGILGALEPAFDEIVVTHNGSPRAMETDALAGIALEIFGEDRVVV 425 Query 433 AENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 A L DA++ AT++V++AA D G FS TGIVITGSVVTAGAARTLFG+DPQ Sbjct 426 APTLLDAVETATAMVEEAAEDGGAEG--FSGTGIVITGSVVTAGAARTLFGKDPQ 478 >gi|120404904|ref|YP_954733.1| FolC bifunctional protein [Mycobacterium vanbaalenii PYR-1] gi|119957722|gb|ABM14727.1| FolC bifunctional protein [Mycobacterium vanbaalenii PYR-1] Length=471 Score = 654 bits (1686), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/470 (78%), Positives = 406/470 (87%), Gaps = 7/470 (1%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 P PDEIA+LLQVEHLLDQRWPET+I+PS RISALM+LLGSPQ YPSIHI GTNGKTSV Sbjct 6 PKPDEIAALLQVEHLLDQRWPETKIEPSTARISALMELLGSPQLGYPSIHIGGTNGKTSV 65 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 ARMVD+L+TALHRRTGRT SPHLQS VERISIDG+PISPA YV TYREIEP V L+DQQS Sbjct 66 ARMVDSLLTALHRRTGRTISPHLQSAVERISIDGRPISPAAYVDTYREIEPFVELVDQQS 125 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 QA+ GGP MSKFEV+TAMAFAAFADAPVDVAVVEVG+GGRWDATNVINAPVAV+TPI Sbjct 126 QAA---GGPRMSKFEVVTAMAFAAFADAPVDVAVVEVGLGGRWDATNVINAPVAVVTPIG 182 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEVLLAESVRADASV 256 IDH DYLG IA IAGEKAGIITR D DTVAV+ RQVP+ MEVLLA++VR DA+V Sbjct 183 IDHADYLGDTIAEIAGEKAGIITRQDDDLVPTDTVAVLARQVPEAMEVLLAQAVRCDAAV 242 Query 257 AREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAG 316 AREDSEF VL RQ+A+GGQ+L+LQGLGGVY DI+LPLHGEHQAHNAVLALA+VEAFFGAG Sbjct 243 AREDSEFTVLGRQVAIGGQLLELQGLGGVYPDIFLPLHGEHQAHNAVLALAAVEAFFGAG 302 Query 317 AQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLV 376 AQRQLD DAVRAGFAAVTSPGRLER+RSAPTVFIDAAHNPAGA+AL + L EFDFR+LV Sbjct 303 AQRQLDVDAVRAGFAAVTSPGRLERLRSAPTVFIDAAHNPAGAAALVEALRDEFDFRYLV 362 Query 377 GVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENL 436 GV+SV+GDKDVDGILAALE FD +VVTHNGSPRAL+V ALA+ A E FGP+RV TA L Sbjct 363 GVVSVMGDKDVDGILAALETAFDQIVVTHNGSPRALEVVALAVKAEEIFGPERVVTASTL 422 Query 437 RDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 DAI+ AT+LV+++ + GIVITGSVVTAGAARTLFG+DP Sbjct 423 PDAIETATALVEESGS--AGDAAGMGGAGIVITGSVVTAGAARTLFGKDP 470 >gi|126436139|ref|YP_001071830.1| FolC bifunctional protein [Mycobacterium sp. JLS] gi|126235939|gb|ABN99339.1| FolC bifunctional protein [Mycobacterium sp. JLS] Length=467 Score = 638 bits (1646), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/471 (78%), Positives = 413/471 (88%), Gaps = 11/471 (2%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 PTPDEIA+LLQVEHLLD RWPET+I+PS RISAL+++LG+PQR YPSIHIAGTNGKTSV Sbjct 6 PTPDEIAALLQVEHLLDARWPETKIEPSTARISALLEMLGNPQRGYPSIHIAGTNGKTSV 65 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 ARMVDAL+TAL RRTGRTTSPHLQS VERI+IDG+PISPA+YV YREIEP V ++D++S Sbjct 66 ARMVDALLTALSRRTGRTTSPHLQSAVERIAIDGEPISPARYVEVYREIEPFVLMVDERS 125 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 + + GGP +SKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNV+NAPVAVITPI Sbjct 126 EEA---GGPRLSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVVNAPVAVITPIG 182 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEVLLAESVRADASV 256 IDH DYLG IA IAGEKAGIITR PD DTVAVIGRQ P+ MEVLLA++VRADA+V Sbjct 183 IDHADYLGDTIAEIAGEKAGIITRQPDDLVPTDTVAVIGRQAPEAMEVLLAQAVRADAAV 242 Query 257 AREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAG 316 AREDSEFAVL RQ+AVGGQ+L+LQGLGGVY +I+LPLHGEHQAHNA+LALA+VEAFFGAG Sbjct 243 AREDSEFAVLSRQVAVGGQLLELQGLGGVYPEIFLPLHGEHQAHNAILALAAVEAFFGAG 302 Query 317 AQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLV 376 A+RQLD DAVRAGFAA SPGRLER+RSAPTVFIDAAHNPAGA+ALA L EFDFRFLV Sbjct 303 AERQLDIDAVRAGFAAAASPGRLERLRSAPTVFIDAAHNPAGAAALADALQTEFDFRFLV 362 Query 377 GVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENL 436 GV+SV+GDKDVDGILAALEP FD +VVTHNGSPRALDVEALA+ A ERFGP+RV A L Sbjct 363 GVVSVMGDKDVDGILAALEPAFDQIVVTHNGSPRALDVEALAVRAEERFGPERVIRAATL 422 Query 437 RDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 DAI+ AT++V+D+ G+ + G+VITGSVVTAGAARTLFGRDPQ Sbjct 423 PDAIETATAVVEDS------GGEGLAGAGMVITGSVVTAGAARTLFGRDPQ 467 >gi|108800523|ref|YP_640720.1| FolC bifunctional protein [Mycobacterium sp. MCS] gi|119869662|ref|YP_939614.1| FolC bifunctional protein [Mycobacterium sp. KMS] gi|108770942|gb|ABG09664.1| FolC bifunctional protein [Mycobacterium sp. MCS] gi|119695751|gb|ABL92824.1| FolC bifunctional protein [Mycobacterium sp. KMS] Length=467 Score = 638 bits (1645), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/471 (78%), Positives = 413/471 (88%), Gaps = 11/471 (2%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 PTPDEIA+LLQVEHLLD RWPET+I+PS RISAL+++LG+PQR YPSIHIAGTNGKTSV Sbjct 6 PTPDEIAALLQVEHLLDARWPETKIEPSTARISALLEMLGNPQRGYPSIHIAGTNGKTSV 65 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 ARMVDAL+TAL RRTGRTTSPHLQS VER++IDG+PISPA+YV YREIEP V ++D++S Sbjct 66 ARMVDALLTALSRRTGRTTSPHLQSAVERVAIDGEPISPARYVEVYREIEPFVLMVDERS 125 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 + + GGP +SKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNV+NAPVAVITPI Sbjct 126 EEA---GGPRLSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVVNAPVAVITPIG 182 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEVLLAESVRADASV 256 IDH DYLG IA IAGEKAGIITR PD DTVAVIGRQ P+ MEVLLA++VRADA+V Sbjct 183 IDHADYLGDTIAEIAGEKAGIITRQPDDLVPTDTVAVIGRQAPEAMEVLLAQAVRADAAV 242 Query 257 AREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAG 316 AREDSEFAVL RQ+AVGGQ+L+LQGLGGVY +I+LPLHGEHQAHNA+LALA+VEAFFGAG Sbjct 243 AREDSEFAVLSRQVAVGGQLLELQGLGGVYPEIFLPLHGEHQAHNAILALAAVEAFFGAG 302 Query 317 AQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLV 376 A+RQLD DAVRAGFAA SPGRLER+RSAPTVFIDAAHNPAGA+ALA L EFDFRFLV Sbjct 303 AERQLDIDAVRAGFAAAASPGRLERLRSAPTVFIDAAHNPAGAAALADALQTEFDFRFLV 362 Query 377 GVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENL 436 GV+SV+GDKDVDGILAALEP FD +VVTHNGSPRALDVEALA+ A ERFGP+RV A L Sbjct 363 GVVSVMGDKDVDGILAALEPAFDQIVVTHNGSPRALDVEALAVRAEERFGPERVIRAATL 422 Query 437 RDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 DAI+ AT++V+D+ G+ + G+VITGSVVTAGAARTLFGRDPQ Sbjct 423 PDAIETATAVVEDS------GGEGLAGAGMVITGSVVTAGAARTLFGRDPQ 467 >gi|145223218|ref|YP_001133896.1| FolC bifunctional protein [Mycobacterium gilvum PYR-GCK] gi|315443676|ref|YP_004076555.1| folylpolyglutamate synthase/dihydrofolate synthase [Mycobacterium sp. Spyr1] gi|145215704|gb|ABP45108.1| FolC bifunctional protein [Mycobacterium gilvum PYR-GCK] gi|315261979|gb|ADT98720.1| folylpolyglutamate synthase/dihydrofolate synthase [Mycobacterium sp. Spyr1] Length=471 Score = 633 bits (1633), Expect = 2e-179, Method: Compositional matrix adjust. Identities = 364/470 (78%), Positives = 411/470 (88%), Gaps = 7/470 (1%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 PTPDEIA+LLQVEHLLDQRWPET+I+P RISAL+++LGSPQ+ YPSIHI GTNGKTSV Sbjct 6 PTPDEIAALLQVEHLLDQRWPETKIEPGTGRISALLEMLGSPQQGYPSIHIGGTNGKTSV 65 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 ARMVDAL+TA RRTGRTTSPHLQS VERISIDG PISPA YV TYREIEP V L+DQQS Sbjct 66 ARMVDALLTAFSRRTGRTTSPHLQSAVERISIDGVPISPAAYVDTYREIEPFVELVDQQS 125 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 +++ GGP MSKFEV+TAMAFAAFADAPVDVAVVEVG+GGRWDATNV+NAPVAVITPI Sbjct 126 ESA---GGPKMSKFEVVTAMAFAAFADAPVDVAVVEVGLGGRWDATNVVNAPVAVITPIG 182 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEVLLAESVRADASV 256 +DHVDYLG IA IAGEKAGIITR D DTVAV+ RQVP+ MEVLLAE+VRADA+V Sbjct 183 VDHVDYLGGTIAEIAGEKAGIITRQADDLVPTDTVAVLARQVPEAMEVLLAEAVRADAAV 242 Query 257 AREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAG 316 AREDSEFA+L RQ+A+GGQ+L+LQGLGGVY+DI+LPLHGEHQAHNAV+ALA+VEAFFGAG Sbjct 243 AREDSEFAILGRQVAIGGQLLELQGLGGVYTDIFLPLHGEHQAHNAVVALAAVEAFFGAG 302 Query 317 AQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLV 376 RQLD D VRAGFAAVTSPGRLERMR+APTVFIDAAHNPAGA+AL++ L EFDFR+LV Sbjct 303 TDRQLDVDTVRAGFAAVTSPGRLERMRNAPTVFIDAAHNPAGAAALSEALRDEFDFRYLV 362 Query 377 GVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENL 436 GV+SV+GDKDVDGILAALEP D +VVTHNGSPRAL+ ALA+ A E FGP+RV TA L Sbjct 363 GVVSVMGDKDVDGILAALEPALDQIVVTHNGSPRALEAAALAVKAEEIFGPERVITAATL 422 Query 437 RDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 DAI+ AT++V+D+ +D D AG S GIVITGSVVTAGAARTLFG+DP Sbjct 423 PDAIETATAVVEDSGSDGDAAG--MSGAGIVITGSVVTAGAARTLFGKDP 470 >gi|54023316|ref|YP_117558.1| putative folylpolyglutamate synthetase [Nocardia farcinica IFM 10152] gi|54014824|dbj|BAD56194.1| putative folylpolyglutamate synthetase [Nocardia farcinica IFM 10152] Length=493 Score = 610 bits (1573), Expect = 2e-172, Method: Compositional matrix adjust. Identities = 330/478 (70%), Positives = 389/478 (82%), Gaps = 9/478 (1%) Query 11 SGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIA 70 +G+ G P+P E+A + VE LDQRWPET+I+PSLTRI+ LMDLLGSPQ++YP+IHIA Sbjct 22 TGARLGSGPSPVELAEMALVEAELDQRWPETKIEPSLTRIATLMDLLGSPQQAYPAIHIA 81 Query 71 GTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPL 130 GTNGKTSV RM+DAL+TALHRRTGR SPHLQ ERISID PISPA+YV TYREI+P Sbjct 82 GTNGKTSVTRMIDALLTALHRRTGRIISPHLQLATERISIDNAPISPAKYVETYREIQPY 141 Query 131 VALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAP 190 V +IDQQS A GGPAMSKFEVLT MA+AAFA+ PVDVAVVE GMGG WDATNVI+ Sbjct 142 VEMIDQQS---AAVGGPAMSKFEVLTGMAYAAFAETPVDVAVVETGMGGTWDATNVIDGQ 198 Query 191 VAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEVLLAE 248 VAVITPI +DH +YLG D+A IAGEKAGII RAP+ DTVAVI +Q P+ MEVLL Sbjct 199 VAVITPIGLDHTEYLGPDLASIAGEKAGIIKRAPESLVPRDTVAVIAQQEPEAMEVLLRR 258 Query 249 SVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALAS 308 +V DA+VARE +EF VL R+IAVGGQ L+LQGLGGVY +I+LPLHGEHQA NAVLALA+ Sbjct 259 AVEVDAAVAREGAEFTVLSRRIAVGGQQLELQGLGGVYDEIFLPLHGEHQARNAVLALAA 318 Query 309 VEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAH 368 VEAFFGAGAQRQLD +AVRAGFAAV SPGR+ERMRSAP++F+DAAHNPAGA ALA T++ Sbjct 319 VEAFFGAGAQRQLDVEAVRAGFAAVASPGRMERMRSAPSIFVDAAHNPAGARALATTIST 378 Query 369 EFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPD 428 EFDFR LVGV++VLGDKD GIL ALEPVFD +VVT NGSPRAL+++ALA A +RFG + Sbjct 379 EFDFRKLVGVIAVLGDKDAAGILEALEPVFDEIVVTTNGSPRALEIDALADLAVQRFGDE 438 Query 429 RVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 RV TA+ L DA++ A +L ++ +G+ S G+V+TGSVVTAGAAR LFG+DP Sbjct 439 RVVTAQTLPDALETAIALAEEVGE----SGEMVSGAGVVVTGSVVTAGAARALFGKDP 492 >gi|312140348|ref|YP_004007684.1| dihydrofolate synthetase/folylpolyglutamate synthetase folc [Rhodococcus equi 103S] gi|311889687|emb|CBH49004.1| dihydrofolate synthetase/folylpolyglutamate synthetase FolC [Rhodococcus equi 103S] Length=476 Score = 595 bits (1535), Expect = 5e-168, Method: Compositional matrix adjust. Identities = 332/474 (71%), Positives = 387/474 (82%), Gaps = 13/474 (2%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 P P ++A L VE LDQRWPET+I+PSLTRISALMDLLGSPQ SYP+IH+AGTNGKTSV Sbjct 9 PDPVDLAELALVEAELDQRWPETKIEPSLTRISALMDLLGSPQHSYPAIHVAGTNGKTSV 68 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 RM+DAL+T LHRRTGRTTSPHLQ ERISIDG PIS YV TYREIEP + +IDQQS Sbjct 69 TRMIDALMTHLHRRTGRTTSPHLQLATERISIDGSPISVRTYVDTYREIEPYIRMIDQQS 128 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 +A+ GGPAMSKFEV TAMA+AAFA+APVDVAVVE G+GG+WDATNVI+A VAVITPI Sbjct 129 EAA---GGPAMSKFEVTTAMAYAAFAEAPVDVAVVETGLGGKWDATNVIDAQVAVITPIG 185 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDG-----SP-DTVAVIGRQVPKVMEVLLAESVRA 252 +DH+DYLG D+A IAGEKAGII + + +P DTVA+I Q P+VM+VLL +V Sbjct 186 LDHMDYLGPDLASIAGEKAGIIKKGRESGVEGVAPVDTVAIIAEQAPEVMDVLLRRAVEV 245 Query 253 DASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAF 312 DA+VARE SEF VLRRQIA+GGQ L+LQGLGGVY DI+LPLHGEHQA NA LALA+VEAF Sbjct 246 DAAVAREGSEFRVLRRQIAIGGQQLELQGLGGVYEDIFLPLHGEHQARNASLALAAVEAF 305 Query 313 FGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDF 372 FGAG RQLD DA+RAGFA+V +PGRLER+R+APTVF+DAAHNP GA ALA L+ EFDF Sbjct 306 FGAGPDRQLDADAIRAGFASVVNPGRLERVRNAPTVFLDAAHNPHGAQALAAALSAEFDF 365 Query 373 RFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRT 432 R LVGV+SV+GDKDVDGIL+ALEPVFD +VVTHNGSPRA+DVE LA A RFG +RV Sbjct 366 RKLVGVVSVMGDKDVDGILSALEPVFDEIVVTHNGSPRAMDVEDLANRAVARFGDERVVV 425 Query 433 AENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 A L DA++ A L ++ A+P G+A S G+V+TGSVVTAG AR+LFG+DP Sbjct 426 ASTLPDALETAIGLAEE-VAEP---GEAVSGAGVVVTGSVVTAGVARSLFGKDP 475 >gi|333918790|ref|YP_004492371.1| putative folylpolyglutamate synthetase [Amycolicicoccus subflavus DQS3-9A1] gi|333481011|gb|AEF39571.1| Putative folylpolyglutamate synthetase [Amycolicicoccus subflavus DQS3-9A1] Length=495 Score = 595 bits (1534), Expect = 6e-168, Method: Compositional matrix adjust. Identities = 306/482 (64%), Positives = 374/482 (78%), Gaps = 9/482 (1%) Query 7 GPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPS 66 GP + PT ++A L VE LDQRWPET+I+PSL RISALMD+LG+PQ S+PS Sbjct 20 GPETPDTPLDDTPTAADLAELAAVEAELDQRWPETKIEPSLARISALMDVLGTPQHSFPS 79 Query 67 IHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYRE 126 IHIAGTNGKTSV+RM+DAL+T L +RTGRTTSPHLQ ERIS+D PI+P +YV TY E Sbjct 80 IHIAGTNGKTSVSRMIDALLTRLGQRTGRTTSPHLQIVTERISVDNAPIAPRRYVDTYVE 139 Query 127 IEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNV 186 ++P + +ID QSQAS GGP MSKFEVLTA+AF+AFADAP+DV ++EVG+GG WDATNV Sbjct 140 LKPYIEMIDAQSQAS---GGPRMSKFEVLTAIAFSAFADAPIDVGIIEVGLGGTWDATNV 196 Query 187 INAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEV 244 +N VAVITPIS DH++YLG D+A IAGEKAGII +AP+ DTVAV+ +Q P+ MEV Sbjct 197 VNGQVAVITPISTDHIEYLGPDLASIAGEKAGIIKKAPEKLIPTDTVAVVAQQEPEAMEV 256 Query 245 LLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVL 304 ++ +V ADA+VARE SEF V RQ+AVGGQ L LQGLGGVY DI+LPLHGEHQA NA + Sbjct 257 VMRRAVEADAAVAREGSEFQVTLRQVAVGGQQLTLQGLGGVYDDIFLPLHGEHQARNASV 316 Query 305 ALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQ 364 ALA+VEAFFGAG RQLD +AVR FA+V SPGRLER+R+APTVF+DAAHNP GA ALA Sbjct 317 ALAAVEAFFGAGRDRQLDVEAVRDAFASVASPGRLERVRAAPTVFLDAAHNPHGAKALAS 376 Query 365 TLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGER 424 L+ EFDFR L+G+++V+ DKD GI+ ALEPVFD +VVT NGS RA+ + LA A + Sbjct 377 ALSSEFDFRRLIGIVAVMADKDASGIVEALEPVFDEIVVTTNGSSRAMHPDELAAVALPK 436 Query 425 FGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGR 484 FG DRV + +L DAI++A + +D +P G+ S GIVITGSVVTAG ARTLFG+ Sbjct 437 FGEDRVIVSPDLADAIEIAVARAED-TREP---GEHVSGAGIVITGSVVTAGVARTLFGK 492 Query 485 DP 486 +P Sbjct 493 EP 494 >gi|325677075|ref|ZP_08156744.1| tetrahydrofolate synthase [Rhodococcus equi ATCC 33707] gi|325552060|gb|EGD21753.1| tetrahydrofolate synthase [Rhodococcus equi ATCC 33707] Length=476 Score = 594 bits (1531), Expect = 1e-167, Method: Compositional matrix adjust. Identities = 331/474 (70%), Positives = 387/474 (82%), Gaps = 13/474 (2%) Query 19 PTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSV 78 P P ++A L VE LDQRWPET+I+PSLTRISALMDLLGSPQ SYP+IH+AGTNGKTSV Sbjct 9 PDPVDLAELALVEAELDQRWPETKIEPSLTRISALMDLLGSPQHSYPAIHVAGTNGKTSV 68 Query 79 ARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQS 138 RM+DAL+T LHRRTGRTTSPHLQ ERISIDG PIS YV TYREIEP + +ID+QS Sbjct 69 TRMIDALMTHLHRRTGRTTSPHLQLATERISIDGSPISVRTYVDTYREIEPYIRMIDEQS 128 Query 139 QASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPIS 198 +A+ GGPAMSKFEV TAMA+AAFA+APVDVAVVE G+GG+WDATNVI+A VAVITPI Sbjct 129 EAA---GGPAMSKFEVTTAMAYAAFAEAPVDVAVVETGLGGKWDATNVIDAQVAVITPIG 185 Query 199 IDHVDYLGADIAGIAGEKAGIITRAPDG-----SP-DTVAVIGRQVPKVMEVLLAESVRA 252 +DH+DYLG D+A IAGEKAGII + + +P DTVA+I Q P+VM+VLL +V Sbjct 186 LDHMDYLGPDLASIAGEKAGIIKKGRESGVEGVAPVDTVAIIAEQAPEVMDVLLRRAVEV 245 Query 253 DASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAF 312 DA+VARE SEF VLRRQIA+GGQ L+LQGLGGVY DI+LPLHGEHQA NA LALA+VEAF Sbjct 246 DAAVAREGSEFRVLRRQIAIGGQQLELQGLGGVYEDIFLPLHGEHQARNASLALAAVEAF 305 Query 313 FGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDF 372 FGAG RQLD DA+RAGFA+V +PGRLER+R+APTVF+DAAHNP GA ALA L+ EFDF Sbjct 306 FGAGPDRQLDADAIRAGFASVVNPGRLERVRNAPTVFLDAAHNPHGAQALAAALSAEFDF 365 Query 373 RFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRT 432 R LVGV+SV+GDKDVDGIL+ALEPVFD +VVTHNGSPRA+DVE LA A RFG +RV Sbjct 366 RKLVGVVSVMGDKDVDGILSALEPVFDEIVVTHNGSPRAMDVEDLANRAVARFGDERVVV 425 Query 433 AENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 A L DA++ A L ++ A+P G+A S G+V+TGSVVTAG AR+LFG+DP Sbjct 426 ASTLPDALETAIGLAEE-VAEP---GEAVSGAGVVVTGSVVTAGVARSLFGKDP 475 >gi|226360453|ref|YP_002778231.1| folylpolyglutamate synthase [Rhodococcus opacus B4] gi|226238938|dbj|BAH49286.1| folylpolyglutamate synthase [Rhodococcus opacus B4] Length=475 Score = 592 bits (1525), Expect = 7e-167, Method: Compositional matrix adjust. Identities = 325/470 (70%), Positives = 388/470 (83%), Gaps = 10/470 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 +P ++A L VE LD+RWPET+I+PSL+RI+ALMD+LGSPQ YP+IH+ GTNGKTSV Sbjct 12 SPVDLAELTLVEAELDRRWPETKIEPSLSRIAALMDILGSPQHGYPAIHVTGTNGKTSVT 71 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+DAL+TALHRRTGRTTSPHLQ ERISIDG+P+SP +YV TYREIEP V +IDQQSQ Sbjct 72 RMIDALLTALHRRTGRTTSPHLQLATERISIDGRPVSPRRYVDTYREIEPYVQMIDQQSQ 131 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A+ GGPAMSKFEVLTAMA+AAFA+APVDVAVVEVG+GGRWDATNVI+ +AVITPIS+ Sbjct 132 AA---GGPAMSKFEVLTAMAYAAFAEAPVDVAVVEVGLGGRWDATNVIDGQIAVITPISL 188 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS---PDTVAVIGRQVPKVMEVLLAESVRADASV 256 DH +YLG D+AGIA EKAGII + + + DTVA++ Q P+VM+VLL +V DA+V Sbjct 189 DHAEYLGDDLAGIAQEKAGIIKKGREDALVPRDTVAILAEQTPEVMDVLLRRAVEVDAAV 248 Query 257 AREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAG 316 ARE SEF VL RQIAVGGQ L+LQGLGG+Y+DI+LPLHGEHQA NA LALA+VEAFFGAG Sbjct 249 AREGSEFTVLARQIAVGGQQLELQGLGGIYTDIFLPLHGEHQARNASLALAAVEAFFGAG 308 Query 317 AQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLV 376 +RQLD DA+R GFA+V +PGRLER+R+APTVF+DAAHNP GA ALA L EFDFR LV Sbjct 309 PERQLDQDAIREGFASVVNPGRLERVRNAPTVFLDAAHNPDGARALAAALTAEFDFRKLV 368 Query 377 GVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENL 436 GV+SV+GDKDVDGIL+ALEPVFD +VVTHNGS RA+DVE LA A +FG +RV A L Sbjct 369 GVVSVMGDKDVDGILSALEPVFDELVVTHNGSARAMDVEDLANLAVAKFGDERVVVAPTL 428 Query 437 RDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 DA++ A L ++ A+P G+A S G+V+TGSVVTAGAARTLFG+DP Sbjct 429 ADALETAIGLAEE-VAEP---GEAVSGAGVVVTGSVVTAGAARTLFGKDP 474 >gi|111018327|ref|YP_701299.1| tetrahydrofolylpolyglutamate synthase [Rhodococcus jostii RHA1] gi|110817857|gb|ABG93141.1| probable tetrahydrofolylpolyglutamate synthase [Rhodococcus jostii RHA1] Length=475 Score = 585 bits (1509), Expect = 4e-165, Method: Compositional matrix adjust. Identities = 323/470 (69%), Positives = 386/470 (83%), Gaps = 10/470 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 +P ++A L VE LD+RWPET+I+PSLTRI+ALMD+LGSPQ YP+IH+ GTNGKTSV Sbjct 12 SPVDLAELTLVEAELDKRWPETKIEPSLTRIAALMDVLGSPQHGYPAIHVTGTNGKTSVT 71 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+DAL+TALHRRTGRTTSPHLQ ERIS+DG+P+SP +YV TYREIEP V +IDQQSQ Sbjct 72 RMIDALLTALHRRTGRTTSPHLQLATERISLDGRPVSPRRYVDTYREIEPYVQMIDQQSQ 131 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A+ GGPAMSKFEVLTAMA+AAFA+APVDVAVVEVG+GGRWDATNVI+ +AVITPIS+ Sbjct 132 AA---GGPAMSKFEVLTAMAYAAFAEAPVDVAVVEVGLGGRWDATNVIDGEIAVITPISL 188 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS---PDTVAVIGRQVPKVMEVLLAESVRADASV 256 DH +YLG D+AGIA EKAGII + + + D VA++ Q P+VMEVLL +V DA+V Sbjct 189 DHAEYLGDDLAGIAEEKAGIIKKGREDALVPRDAVAILAEQTPEVMEVLLRRAVEVDAAV 248 Query 257 AREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAG 316 ARE SEF VL RQIAVGGQ L+LQGLGGVY+DI+LPLHGEHQA NA LALA+VEAFFGAG Sbjct 249 AREGSEFTVLARQIAVGGQQLELQGLGGVYTDIFLPLHGEHQARNASLALAAVEAFFGAG 308 Query 317 AQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLV 376 +RQLD +A+R FA+V +PGRLER+RSAPTVF+DAAHNP GA ALA L EFDFR LV Sbjct 309 PERQLDQEAIREAFASVVNPGRLERVRSAPTVFLDAAHNPDGARALAAALTAEFDFRKLV 368 Query 377 GVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENL 436 GV+SV+GDKDVDGIL+ALEPVFD +VVT+NGS RA+DV+ LA A +FG +RV A L Sbjct 369 GVVSVMGDKDVDGILSALEPVFDELVVTNNGSARAMDVDDLANLAVAKFGDERVVVAPTL 428 Query 437 RDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 DA++ A L ++ A+P G+A S G+V+TGSVVTAGAARTLFG+DP Sbjct 429 ADALETAIGLAEE-VAEP---GEAVSGAGVVVTGSVVTAGAARTLFGKDP 474 >gi|325048882|dbj|BAJ79308.1| putative FolC bifunctional protein [Rhodococcus erythropolis] Length=479 Score = 582 bits (1500), Expect = 4e-164, Method: Compositional matrix adjust. Identities = 333/484 (69%), Positives = 386/484 (80%), Gaps = 9/484 (1%) Query 5 NSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 +S P A VPTP +IA L VE LD+RWPET+I+PSLTRI ALMD+LGSPQ +Y Sbjct 2 SSYEPSQFDAQSSVPTPVDIAELALVEAELDKRWPETKIEPSLTRIEALMDVLGSPQHNY 61 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PS+H+ GTNGKTSV RM+D+L+TALHRRTGRTTSPHLQ ERISIDG PISP YV T+ Sbjct 62 PSVHVTGTNGKTSVTRMIDSLMTALHRRTGRTTSPHLQIATERISIDGHPISPRLYVDTF 121 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V +ID QS+ + GGPAMSKFEVLTAMA+AAFA+APVDVAVVEVG+GGRWDAT Sbjct 122 REIEPYVQMIDAQSEEA---GGPAMSKFEVLTAMAYAAFAEAPVDVAVVEVGLGGRWDAT 178 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRA-PDGSP-DTVAVIGRQVPKVM 242 NVI+ VAVITPIS+DH +YLG D+AGIA EKAGII + D P DTVA+I Q P+VM Sbjct 179 NVIDGQVAVITPISLDHAEYLGTDLAGIAEEKAGIIKKGREDLVPVDTVAIIAEQTPEVM 238 Query 243 EVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNA 302 EVLL +V +A+VARE SEF VL RQIAVGGQ L+LQGL GVY+DI+LPLHGEHQAHNA Sbjct 239 EVLLRRAVEVEAAVAREGSEFKVLARQIAVGGQQLELQGLSGVYTDIFLPLHGEHQAHNA 298 Query 303 VLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASAL 362 LALA+VEAFFGAG RQLD DA+R GFA+V +PGRLER+RSAPTVF+DAAHNP GA AL Sbjct 299 ALALAAVEAFFGAGPDRQLDQDAIRNGFASVVNPGRLERVRSAPTVFLDAAHNPDGARAL 358 Query 363 AQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAG 422 A LA EFDFR LVGV+SV+ DKDVD IL A E VFD +VVTHNGSPRA+DVE LA A Sbjct 359 AAALAAEFDFRKLVGVVSVMADKDVDAILTAFESVFDEIVVTHNGSPRAMDVEELANIAV 418 Query 423 ERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLF 482 +FG +RV A L DA++VA + + A+P G+A S G+V+TGSVVTAGAARTLF Sbjct 419 AKFGDERVVVAPVLADALEVAIEIAEQ-VAEP---GEAVSGAGVVVTGSVVTAGAARTLF 474 Query 483 GRDP 486 G+DP Sbjct 475 GKDP 478 >gi|229493122|ref|ZP_04386914.1| FolC bifunctional protein [Rhodococcus erythropolis SK121] gi|229319853|gb|EEN85682.1| FolC bifunctional protein [Rhodococcus erythropolis SK121] Length=479 Score = 578 bits (1491), Expect = 6e-163, Method: Compositional matrix adjust. Identities = 331/484 (69%), Positives = 385/484 (80%), Gaps = 9/484 (1%) Query 5 NSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 +S P A VPTP +IA L VE LD+RWPET+I+PSLTRI ALMD+LGSPQ +Y Sbjct 2 SSYEPSQFDAQSSVPTPVDIAELALVEAELDKRWPETKIEPSLTRIEALMDVLGSPQHNY 61 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PS+H+ GTNGKTSV RM+D+L+TALHRRTGRTTSPHLQ ERISIDG PISP YV T+ Sbjct 62 PSVHVTGTNGKTSVTRMIDSLMTALHRRTGRTTSPHLQIATERISIDGHPISPRLYVDTF 121 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V +ID QS+ + GGPAMSKFEVLTAMA+AAFA+APVDVAVVEVG+GGRWDAT Sbjct 122 REIEPYVQMIDAQSEEA---GGPAMSKFEVLTAMAYAAFAEAPVDVAVVEVGLGGRWDAT 178 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRA-PDGSP-DTVAVIGRQVPKVM 242 NVI+ VAVITPIS+DH +YLG D+AGIA EKAGII + D P DTVA+I Q P+VM Sbjct 179 NVIDGQVAVITPISLDHAEYLGTDLAGIAEEKAGIIKKGREDLVPVDTVAIIAEQTPEVM 238 Query 243 EVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNA 302 EVLL +V +A+VARE SEF VL RQIAVGGQ L+LQGL GVY+DI+LPLHGEHQA NA Sbjct 239 EVLLRRAVEVEAAVAREGSEFKVLARQIAVGGQQLELQGLSGVYTDIFLPLHGEHQARNA 298 Query 303 VLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASAL 362 LALA+VEAFFGAG RQLD DA+R GFA++ +PGRLER+RSAPTVF+DAAHNP GA AL Sbjct 299 ALALAAVEAFFGAGPDRQLDQDAIRNGFASIVNPGRLERVRSAPTVFLDAAHNPDGARAL 358 Query 363 AQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAG 422 A LA EFDFR LVGV+SV+ DKDVD IL A E VFD +VVTHNGSPRA+DVE LA A Sbjct 359 AAALAAEFDFRKLVGVVSVMADKDVDAILTAFESVFDEIVVTHNGSPRAMDVEELANIAV 418 Query 423 ERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLF 482 +FG +RV A L DA++VA + + A+P G+A S G+V+TGSVVTAGAARTLF Sbjct 419 AKFGDERVVVAPVLADALEVAIEIAEQ-VAEP---GEAVSGAGVVVTGSVVTAGAARTLF 474 Query 483 GRDP 486 G+DP Sbjct 475 GKDP 478 >gi|296139192|ref|YP_003646435.1| FolC bifunctional protein [Tsukamurella paurometabola DSM 20162] gi|296027326|gb|ADG78096.1| FolC bifunctional protein [Tsukamurella paurometabola DSM 20162] Length=471 Score = 578 bits (1489), Expect = 9e-163, Method: Compositional matrix adjust. Identities = 314/469 (67%), Positives = 372/469 (80%), Gaps = 9/469 (1%) Query 21 PDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVAR 80 PD++A L QVE LDQRWPET+I+PSL RISALM LLGSPQ +YPSI IAGTNGK+S AR Sbjct 10 PDDLADLAQVEAELDQRWPETKIEPSLARISALMQLLGSPQDAYPSIQIAGTNGKSSTAR 69 Query 81 MVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQA 140 M+D+L+ A RRTGR TSPHLQ ERI+IDG P++ QYV TYRE+EP + L+DQQS+A Sbjct 70 MIDSLLLAFSRRTGRITSPHLQLATERIAIDGVPLTAKQYVETYRELEPYIELVDQQSEA 129 Query 141 SAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISID 200 + GP MSKFEVLTAMAFAAFA+APVDVAVVEVG+GG WDATNV+ A VAVITPI +D Sbjct 130 A---DGPRMSKFEVLTAMAFAAFAEAPVDVAVVEVGLGGTWDATNVVTAEVAVITPIGLD 186 Query 201 HVDYLGADIAGIAGEKAGIITRAPDG--SPDTVAVIGRQVPKVMEVLLAESVRADASVAR 258 HV+ LG D+ IAGEKAGI+ RAP+ DTV ++G+Q P M+VLL ++V DA+VAR Sbjct 187 HVEILGPDLTSIAGEKAGIVKRAPERLIPKDTVMIVGKQEPAAMDVLLHKAVETDAAVAR 246 Query 259 EDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQ 318 E SEFAV+ R++AVGGQ L LQGLGGVY DI+LPLHGEHQA+NA ALA+VEAFFGAGA Sbjct 247 EGSEFAVIERRMAVGGQQLSLQGLGGVYEDIFLPLHGEHQANNAATALAAVEAFFGAGAD 306 Query 319 RQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGV 378 +QLD D VR GFA V SPGRLER+R+APTVFIDAAHNP GA ALA+T+ EFDFR L+GV Sbjct 307 QQLDVDTVREGFATVISPGRLERVRTAPTVFIDAAHNPHGAQALARTVQSEFDFRTLIGV 366 Query 379 LSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRD 438 +SV DKD GIL +EPV D+VVVTHNGSPRAL+VE LA A E FG DRV TA + D Sbjct 367 VSVFADKDAVGILTEIEPVLDTVVVTHNGSPRALEVERLAAIAEEIFGEDRVVTAPTMVD 426 Query 439 AIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 A++ A +L D + D D A S G++ITGSVVTAGAAR+LFG++PQ Sbjct 427 AVETAVALADQESDDEDPA----SGVGVLITGSVVTAGAARSLFGKEPQ 471 >gi|226307286|ref|YP_002767246.1| folylpolyglutamate synthase [Rhodococcus erythropolis PR4] gi|226186403|dbj|BAH34507.1| folylpolyglutamate synthase [Rhodococcus erythropolis PR4] Length=479 Score = 577 bits (1488), Expect = 1e-162, Method: Compositional matrix adjust. Identities = 331/484 (69%), Positives = 384/484 (80%), Gaps = 9/484 (1%) Query 5 NSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSY 64 +S P A VPTP +IA L VE LD+RWPET+I+PSLTRI ALMD+LGSPQ +Y Sbjct 2 SSYEPSQFDAQSSVPTPVDIAELALVEAELDKRWPETKIEPSLTRIEALMDVLGSPQHNY 61 Query 65 PSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATY 124 PS+H+ GTNGKTSV RM+D+L++ALHRRTGRTTSPHLQ ERISIDG PISP YV T+ Sbjct 62 PSVHVTGTNGKTSVTRMIDSLMSALHRRTGRTTSPHLQIATERISIDGHPISPRLYVDTF 121 Query 125 REIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDAT 184 REIEP V +ID QSQ + GGPAMSKFEVLTAMA+AAFA+APVDVAVVEVG+GGRWDAT Sbjct 122 REIEPYVQMIDAQSQEA---GGPAMSKFEVLTAMAYAAFAEAPVDVAVVEVGLGGRWDAT 178 Query 185 NVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRA-PDGSP-DTVAVIGRQVPKVM 242 NVI+ VAVITPIS+DH +YLG D+AGIA EKAGII D P DTVA+I Q P+VM Sbjct 179 NVIDGQVAVITPISLDHAEYLGTDLAGIAEEKAGIIKEGREDLVPVDTVAIIAEQTPEVM 238 Query 243 EVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNA 302 EVLL +V +A+VARE SEF VL RQIAVGGQ L+LQGL GVY+DI+LPLHGEHQA NA Sbjct 239 EVLLRRAVEVEAAVAREGSEFKVLARQIAVGGQQLELQGLSGVYTDIFLPLHGEHQARNA 298 Query 303 VLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASAL 362 LALA+VEAFFGAG RQLD DA+R GFA++ +PGRLER+RSAPTVF+DAAHNP GA AL Sbjct 299 ALALAAVEAFFGAGPDRQLDQDAIRNGFASIVNPGRLERVRSAPTVFLDAAHNPDGARAL 358 Query 363 AQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAG 422 A LA EFDFR LVGV+SV+ DKDVD IL A E VFD +VVTHNGSPRA+DVE LA A Sbjct 359 AAALAAEFDFRKLVGVVSVMADKDVDAILTAFESVFDEIVVTHNGSPRAMDVEELANIAV 418 Query 423 ERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLF 482 +FG +RV A L DA++VA + + A+P G+A S G+V+TGSVVTAGAARTLF Sbjct 419 AKFGDERVVVAPVLADALEVAIEIAEQ-VAEP---GEAVSGAGVVVTGSVVTAGAARTLF 474 Query 483 GRDP 486 G+DP Sbjct 475 GKDP 478 >gi|262201991|ref|YP_003273199.1| FolC bifunctional protein [Gordonia bronchialis DSM 43247] gi|262085338|gb|ACY21306.1| FolC bifunctional protein [Gordonia bronchialis DSM 43247] Length=508 Score = 575 bits (1483), Expect = 4e-162, Method: Compositional matrix adjust. Identities = 312/476 (66%), Positives = 361/476 (76%), Gaps = 15/476 (3%) Query 18 VPTPD---EIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNG 74 VPT D ++A L +VE LD RWPET+I+PSLTRIS LMDLLGSPQ YP IH+AGTNG Sbjct 42 VPTADSVEDLAELAEVEADLDTRWPETKIEPSLTRISTLMDLLGSPQHGYPVIHVAGTNG 101 Query 75 KTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALI 134 KTSV RM+DAL+ ALHRRTGR TSPHLQ ERIS+DGKPI YV TYRE+EP + ++ Sbjct 102 KTSVTRMIDALLVALHRRTGRITSPHLQRVTERISLDGKPIPARTYVDTYRELEPYITMV 161 Query 135 DQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVI 194 D S A+ GGP MSKFEVLTAMA+A FA+APVDVAVVE GMGGRWDATNV+++ VAVI Sbjct 162 DDSSTAA---GGPRMSKFEVLTAMAYAVFAEAPVDVAVVETGMGGRWDATNVVDSAVAVI 218 Query 195 TPISIDHVDYLGADIAGIAGEKAGIITRA-PDG--SPDTVAVIGRQVPKVMEVLLAESVR 251 TPI++DH DYLG + IAGEKAGII A PD D + VI Q P+VM+VLL +V Sbjct 219 TPIAMDHADYLGDTLTAIAGEKAGIIKAADPDALVPVDPITVIAPQDPEVMDVLLRATVD 278 Query 252 ADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEA 311 A VAR SEF VL AVGGQ+L L+GLGGVY +++LPLHG HQA NA LALA+VEA Sbjct 279 AGTVVARAGSEFTVLESVTAVGGQMLTLRGLGGVYDEVFLPLHGAHQAGNAALALAAVEA 338 Query 312 FFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFD 371 FFGAGAQRQLD DAVRAGFA SPGRLER+RSAPTVF DAAHNP GA+ALAQ L EFD Sbjct 339 FFGAGAQRQLDIDAVRAGFAEAASPGRLERLRSAPTVFADAAHNPHGATALAQALVEEFD 398 Query 372 FRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVR 431 FR LVGV+ VLGDKD G+L ALEPVFD VV+T+NGSPRALD LA A E FG +RV Sbjct 399 FRRLVGVVGVLGDKDARGLLEALEPVFDVVVLTNNGSPRALDTSTLADYATEIFGEERVV 458 Query 432 TAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 L DA++ A +L + +V G+ S G+VITGSVVTAGAARTLFG++P+ Sbjct 459 VKPFLPDAVEAAIALAE------EVDGEPVSGAGVVITGSVVTAGAARTLFGKEPR 508 >gi|334564151|ref|ZP_08517142.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium bovis DSM 20582] Length=549 Score = 573 bits (1477), Expect = 2e-161, Method: Compositional matrix adjust. Identities = 310/489 (64%), Positives = 364/489 (75%), Gaps = 23/489 (4%) Query 13 SATGVVPTPD----------EIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQR 62 S TGV PD ++ L +VE L RWPETRIDP+L RISALMDLLGSPQR Sbjct 68 SGTGVADDPDARPPRPVTAADLEELREVEAELTARWPETRIDPTLDRISALMDLLGSPQR 127 Query 63 SYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVA 122 SY SIH+AGTNGKTSV RM+++L+ A HRRTGRTTSPHLQ P ERI++DG P+ P YVA Sbjct 128 SYQSIHVAGTNGKTSVVRMIESLLRAFHRRTGRTTSPHLQLPTERIAVDGVPLHPRDYVA 187 Query 123 TYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWD 182 T+REI+P V ++D +S+A+ GGP MS FEVL MA+AAFADAPVDVAVVEVGMGGRWD Sbjct 188 TWREIQPFVEMVDARSEAA---GGPRMSTFEVLVGMAYAAFADAPVDVAVVEVGMGGRWD 244 Query 183 ATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPD-----GSPDTVAVIGRQ 237 ATNVI+A V+VITP+ +DH DYLG IA IAGEKAGII+ D PDTVAV+ Q Sbjct 245 ATNVIDADVSVITPVGLDHTDYLGDTIAAIAGEKAGIISSPWDTDDLLSPPDTVAVVAEQ 304 Query 238 VPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEH 297 P+ MEV+L ++V ADA+VARE SEF V+ +AVGGQ L L+GLGG Y+DI LPL GEH Sbjct 305 EPEAMEVILRQAVEADAAVAREGSEFGVVESTVAVGGQQLTLRGLGGTYTDIVLPLSGEH 364 Query 298 QAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPA 357 QA NA LALA+VEAFFGAGA RQLD D VR GFA V SPGRLER+RSAP+VFIDA HNP Sbjct 365 QARNAALALAAVEAFFGAGANRQLDVDTVRRGFAQVRSPGRLERVRSAPSVFIDATHNPH 424 Query 358 GASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEAL 417 GA ALA+ + +F FR LVGV+ VL DKD GILA LEPV D VVVT + SPRALDVE L Sbjct 425 GARALAKAVDRDFSFRRLVGVVGVLSDKDARGILAELEPVMDEVVVTQSTSPRALDVETL 484 Query 418 ALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGA 477 A A + FG +RV A L A+++AT L +D D V+G G++ITGSVVTAG Sbjct 485 AEYARDAFGEERVHVAPLLPGAVELATQLAEDDGGDGMVSG-----AGVLITGSVVTAGE 539 Query 478 ARTLFGRDP 486 ARTLFG++P Sbjct 540 ARTLFGKEP 548 >gi|343925348|ref|ZP_08764873.1| folylpolyglutamate synthase [Gordonia alkanivorans NBRC 16433] gi|343764787|dbj|GAA11799.1| folylpolyglutamate synthase [Gordonia alkanivorans NBRC 16433] Length=508 Score = 568 bits (1464), Expect = 8e-160, Method: Compositional matrix adjust. Identities = 310/468 (67%), Positives = 364/468 (78%), Gaps = 12/468 (2%) Query 22 DEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARM 81 D++A L +VE LD RWPETRI+PSLTRI+ALMDLLGSPQ SYP+IH+AGTNGKTSV RM Sbjct 49 DDLAELAEVEAELDTRWPETRIEPSLTRIAALMDLLGSPQHSYPAIHVAGTNGKTSVTRM 108 Query 82 VDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQAS 141 +DAL+TALHRRTGR TSPHLQ ERIS+DGKPI Y+ TYRE+EP + ++D S A+ Sbjct 109 IDALMTALHRRTGRITSPHLQRVTERISVDGKPIRARTYIDTYRELEPYITMVDDSSTAA 168 Query 142 AGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDH 201 GGP MSKFEVLTAMA+A FA+APVDVAVVE GMGGRWDATNVI+ V+VITPI++DH Sbjct 169 ---GGPRMSKFEVLTAMAYAVFAEAPVDVAVVETGMGGRWDATNVIDGIVSVITPIAMDH 225 Query 202 VDYLGADIAGIAGEKAGIITRA-PD--GSPDTVAVIGRQVPKVMEVLLAESVRADASVAR 258 DYLG ++ IAGEKAGII PD G+ D V +I Q P+VMEVLL +V A VAR Sbjct 226 ADYLGDTLSAIAGEKAGIIKPGEPDAVGAVDPVTIIAEQNPEVMEVLLRAAVDAGTVVAR 285 Query 259 EDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQ 318 + SEFAVL AVGGQ+L +QGLGGVY +++LPLHG HQA NA LALA+VEAFFGAG Sbjct 286 QGSEFAVLGSATAVGGQMLTIQGLGGVYDEVFLPLHGAHQAANASLALAAVEAFFGAGQD 345 Query 319 RQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGV 378 RQLD DA+R+GFA V +PGRLER+RSAPTVF DAAHNP GA+ALAQ LA EFDFR L+GV Sbjct 346 RQLDIDAIRSGFATVGNPGRLERLRSAPTVFADAAHNPHGANALAQALAEEFDFRRLIGV 405 Query 379 LSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRD 438 + VLGDKD G+L ALEPV D+VVVT+NGSPRALD E LA A E FG +RV L D Sbjct 406 VGVLGDKDARGLLEALEPVLDTVVVTNNGSPRALDAETLAEYATEVFGEERVVVQPFLPD 465 Query 439 AIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 A++ A +L ++A G S G+VITGSVVTAGAARTLFG++P Sbjct 466 AVEEAIALAEEA------EGQRVSGAGVVITGSVVTAGAARTLFGKEP 507 >gi|336325189|ref|YP_004605155.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium resistens DSM 45100] gi|336101171|gb|AEI08991.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium resistens DSM 45100] Length=529 Score = 535 bits (1378), Expect = 7e-150, Method: Compositional matrix adjust. Identities = 302/489 (62%), Positives = 357/489 (74%), Gaps = 17/489 (3%) Query 7 GPPDSGSATGVVP----TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQR 62 GP VVP T ++A L +VE LDQRWPET+IDP+L R+ LMDLLG+P+R Sbjct 48 GPLRDADGEQVVPPRPITTQDMAELAEVEAELDQRWPETKIDPTLERVQLLMDLLGNPER 107 Query 63 SYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVA 122 ++P IH+AGTNGKTS RM+++L+ A HRRTGRTTSPHLQ ERI+IDG+PI P YVA Sbjct 108 AFPVIHVAGTNGKTSTVRMIESLMRAFHRRTGRTTSPHLQIVTERIAIDGEPIHPQDYVA 167 Query 123 TYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWD 182 +REI+P V ++D +S A KGGP MSKFEVL AMA+A+FADAPVDVAVVE GMGGRWD Sbjct 168 AWREIKPYVEMVDAKS---AEKGGPQMSKFEVLVAMAYASFADAPVDVAVVETGMGGRWD 224 Query 183 ATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGS-----PDTVAVIGRQ 237 ATNV+NA VAVITPI +DH DYLG I IAGEKAGII D PD V VI Q Sbjct 225 ATNVVNADVAVITPIGLDHTDYLGDTIEEIAGEKAGIIKSRWDADDLLTPPDNVTVIAEQ 284 Query 238 VPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEH 297 P M V+LAE+V D++VAR EF VL QIAVGGQ + L+GLGG Y DI+LPL GEH Sbjct 285 DPDAMRVVLAEAVDKDSAVARAGVEFGVLDAQIAVGGQQVTLKGLGGTYEDIFLPLSGEH 344 Query 298 QAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPA 357 QA NA +ALA+ EAFFGAG+ RQLD +AVR GFA VTSPGRLER+RSAP+VFIDA+HNP Sbjct 345 QARNAAVALAAAEAFFGAGSGRQLDIEAVREGFAKVTSPGRLERVRSAPSVFIDASHNPH 404 Query 358 GASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEAL 417 GA ALA +A +F FR LVGV+ VLGDKD GILAALEP+FD VV+T SPRALD E L Sbjct 405 GAEALAAAVARDFSFRRLVGVVGVLGDKDARGILAALEPIFDEVVITRTQSPRALDEETL 464 Query 418 ALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGA 477 A A + FG +RV NL A+++A L +D + V+G G++ITGSVVTAG Sbjct 465 AEYARDAFGEERVHVTTNLPGAVELAIELAEDDGDEGMVSG-----AGVLITGSVVTAGE 519 Query 478 ARTLFGRDP 486 ARTLFGR P Sbjct 520 ARTLFGRQP 528 >gi|260578307|ref|ZP_05846223.1| tetrahydrofolate synthase [Corynebacterium jeikeium ATCC 43734] gi|258603609|gb|EEW16870.1| tetrahydrofolate synthase [Corynebacterium jeikeium ATCC 43734] Length=507 Score = 534 bits (1376), Expect = 1e-149, Method: Compositional matrix adjust. Identities = 294/472 (63%), Positives = 359/472 (77%), Gaps = 14/472 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 TPD++A+L +V+ L+QRWPET+IDP+L R+ LMDLLG P+R++P IH+AGTNGKTSV Sbjct 44 TPDDLAALAEVDAELNQRWPETKIDPTLERVEMLMDLLGHPERAFPVIHVAGTNGKTSVV 103 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+++L+ A HRRTGRTTSPHLQ ERI+IDGKP+ P YV T+R+I+P+V ++D +SQ Sbjct 104 RMIESLMRAFHRRTGRTTSPHLQIVTERIAIDGKPLHPRDYVDTWRDIQPMVEMVDAKSQ 163 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A +GGP MSKFEVL AMA+AAFADAPVDVAVVE GMGGRWDATNV+N+ VAVITPI + Sbjct 164 A---EGGPQMSKFEVLVAMAYAAFADAPVDVAVVETGMGGRWDATNVVNSDVAVITPIGL 220 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS-----PDTVAVIGRQVPKVMEVLLAESVRADA 254 DH DYLG + IAGEKAGII D PD V ++ Q P+ M VLL E+V D+ Sbjct 221 DHTDYLGDTLEEIAGEKAGIIKARWDADDLLTPPDNVTIVAEQEPEAMRVLLEEAVAKDS 280 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 +VAR SEF V+ QIAVGGQ + ++GL G Y+DI+LPL GEHQA NA +ALA+VEAFFG Sbjct 281 AVARAGSEFGVVSSQIAVGGQTVTIRGLAGEYTDIFLPLSGEHQARNAAVALAAVEAFFG 340 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA+RQLD D VR GFA+V SPGRLER+RS P+VFIDA+HNP GA ALA + +F+FR Sbjct 341 AGAERQLDVDTVREGFASVASPGRLERVRSTPSVFIDASHNPHGAKALAAAIDRDFEFRR 400 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 LVGV+ VLGDKD GILAALEPV D VVVT SPRAL V+ LA A + FG +RV A Sbjct 401 LVGVVGVLGDKDARGILAALEPVMDEVVVTEVNSPRALPVDVLAEYAQDAFGEERVHVAV 460 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 NL A++VAT L +D D D S G++ITGSVVTAG ARTLFG++P Sbjct 461 NLPGAVEVATQLAED---DED---GVLSGAGVLITGSVVTAGEARTLFGKEP 506 >gi|68535623|ref|YP_250328.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium jeikeium K411] gi|68263222|emb|CAI36710.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium jeikeium K411] Length=512 Score = 532 bits (1371), Expect = 4e-149, Method: Compositional matrix adjust. Identities = 291/472 (62%), Positives = 359/472 (77%), Gaps = 14/472 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 TP+++A+L +V+ L+QRWPET+IDP+L R+ LMDLLG P+R++P IH+AGTNGKTSV Sbjct 49 TPEDLAALAEVDAELNQRWPETKIDPTLERVEMLMDLLGHPERAFPVIHVAGTNGKTSVV 108 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+++L+ A HRRTGRTTSPHLQ ERI+IDGKP+ P YV T+R+I+P+V ++D +SQ Sbjct 109 RMIESLMRAFHRRTGRTTSPHLQIVTERIAIDGKPLHPRDYVDTWRDIQPMVEMVDAKSQ 168 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A +GGP MSKFEVL AMA+AAFADAPVDVAVVE GMGGRWDATNV+N+ VAVITPI + Sbjct 169 A---EGGPQMSKFEVLVAMAYAAFADAPVDVAVVETGMGGRWDATNVVNSDVAVITPIGL 225 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS-----PDTVAVIGRQVPKVMEVLLAESVRADA 254 DH DYLG + IAGEKAGII D PD V ++ Q P+ M VLL E+V D+ Sbjct 226 DHTDYLGDTLEEIAGEKAGIIKARWDADDLLTPPDNVTIVAEQEPEAMRVLLEEAVAKDS 285 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 +VAR SEF V+ QIAVGGQ + ++GL G Y+DI+LPL GEHQA NA +ALA+VEAFFG Sbjct 286 AVARAGSEFGVVSSQIAVGGQTVTIRGLAGEYTDIFLPLSGEHQARNAAVALAAVEAFFG 345 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA+RQLD D VR GFA+V SPGRLER+RS P+VFIDA+HNP GA ALA + +F+FR Sbjct 346 AGAERQLDVDTVREGFASVASPGRLERVRSTPSVFIDASHNPHGAKALAAAIDRDFEFRR 405 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 LVGV+ VLGDKD GILAALEPV D +VVT SPRAL V+ LA A + FG +RV A Sbjct 406 LVGVVGVLGDKDARGILAALEPVMDEIVVTEVNSPRALPVDVLAEYARDAFGEERVHVAA 465 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 NL A+++AT L +D D D S G++ITGSVVTAG ARTLFG++P Sbjct 466 NLPGAVEIATQLAED---DED---GVLSGAGVLITGSVVTAGEARTLFGKEP 511 >gi|326382835|ref|ZP_08204525.1| FolC bifunctional protein [Gordonia neofelifaecis NRRL B-59395] gi|326198425|gb|EGD55609.1| FolC bifunctional protein [Gordonia neofelifaecis NRRL B-59395] Length=468 Score = 525 bits (1351), Expect = 1e-146, Method: Compositional matrix adjust. Identities = 300/476 (64%), Positives = 359/476 (76%), Gaps = 15/476 (3%) Query 17 VVPTPD---EIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTN 73 + P+PD ++A L +E LD RWPET+I+PSLTRI+ALM+LLG+PQ +YPSIH+AGTN Sbjct 1 MTPSPDSADDLAELQALEAELDTRWPETKIEPSLTRITALMELLGNPQHAYPSIHVAGTN 60 Query 74 GKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVAL 133 GKTSV RM+D+L+ A HRRTGR TSPHLQ ERI+IDG+PIS YV TYR+IEP V + Sbjct 61 GKTSVTRMIDSLLRAFHRRTGRITSPHLQLVTERIAIDGEPISARTYVDTYRDIEPYVTM 120 Query 134 IDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAV 193 +D S A GGP MSKFEVLTA+A+AAFA+AP++VAVVE GMGGRWDATNVI+ V V Sbjct 121 VDDSSTAG---GGPRMSKFEVLTAIAYAAFAEAPIEVAVVETGMGGRWDATNVIDGQVTV 177 Query 194 ITPISIDHVDYLGADIAGIAGEKAGIITRAPDGS---PDTVAVIGRQVPKVMEVLLAESV 250 ITPI+ DH DYLG + IAGEKAGII P + D + VI Q P+V +VLL SV Sbjct 178 ITPIAFDHADYLGDTLTAIAGEKAGIIKPGPSDAVIPMDPITVIAPQEPEVADVLLRASV 237 Query 251 RADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVE 310 A VAR+DSEF VL AVGGQ+L ++GLGGVY +++LPLHG HQA NA LALA+VE Sbjct 238 EAGTIVARQDSEFTVLEAATAVGGQLLSIRGLGGVYDEVFLPLHGAHQAQNAALALAAVE 297 Query 311 AFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEF 370 AFFGAGA RQLD +AVR GFA V SPGRLER+RSAP+VF+DAAHNP GA ALAQ L EF Sbjct 298 AFFGAGADRQLDVEAVREGFATVDSPGRLERVRSAPSVFVDAAHNPHGARALAQALVSEF 357 Query 371 DFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRV 430 DFR LVGV+ VLGDKD G+LA LEPV D VV+T+NGSPRALD +ALA A E FG DRV Sbjct 358 DFRRLVGVIGVLGDKDARGLLAELEPVLDVVVLTNNGSPRALDTDALADIANEVFGEDRV 417 Query 431 RTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 L +A++ A +L +D D G + S G++ITGSVVTAGA RTLFG++P Sbjct 418 VVEPFLPEAVEAAVALAED-----DDQG-SMSGAGVIITGSVVTAGAGRTLFGKEP 467 >gi|340793876|ref|YP_004759339.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium variabile DSM 44702] gi|340533786|gb|AEK36266.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium variabile DSM 44702] Length=468 Score = 524 bits (1349), Expect = 2e-146, Method: Compositional matrix adjust. Identities = 294/472 (63%), Positives = 351/472 (75%), Gaps = 11/472 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 TP+++A+L QVE L++RW ET IDP+L RI LMDLLG+PQR+Y SIHIAGTNGKTS Sbjct 2 TPEDLAALAQVEAELNERWNETHIDPTLDRIRELMDLLGNPQRAYQSIHIAGTNGKTSTV 61 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RMV++L+ A HRRTGRTTSPHLQ ER++IDG+P+ PA YV +REIEP V ++D S+ Sbjct 62 RMVESLLRAFHRRTGRTTSPHLQIATERVAIDGQPMHPADYVRIWREIEPYVDMVDAASE 121 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A KGGP MSKFEVL AMA+AAFADAPVDVAVVEVGMGGRWDATNVI+A V+VI PI + Sbjct 122 A---KGGPRMSKFEVLVAMAYAAFADAPVDVAVVEVGMGGRWDATNVIDADVSVIMPIGL 178 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS-----PDTVAVIGRQVPKVMEVLLAESVRADA 254 DH DYLG IA IA EKAGII + PD V V+ Q P+ MEV+L +V D+ Sbjct 179 DHTDYLGDTIAEIAAEKAGIIKSRWNRDDLLTPPDNVTVVSEQEPEAMEVILRRAVEVDS 238 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 SVAR +EF V+ IAVGGQ L ++GLGG Y +I+LPL G HQA NA +ALA+VEAFFG Sbjct 239 SVARAGAEFGVVESGIAVGGQTLTIRGLGGTYDNIFLPLSGAHQARNAAVALAAVEAFFG 298 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA RQLD + VR GFA V SPGRLER+R+ P++FIDA HNP GA ALA+ + +F FR Sbjct 299 AGAGRQLDIETVRRGFAQVQSPGRLERVRATPSIFIDATHNPHGAKALAEAVDRDFSFRR 358 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 LVGVL +LGDKD GILAALEPV D VVVT NGSPRAL+VE LA A + FG +RV A Sbjct 359 LVGVLGILGDKDARGILAALEPVLDEVVVTRNGSPRALEVETLAEYARDAFGEERVHVAA 418 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 L A+++A L +D D G S G++ITGSVVTAG ARTLFG+DP Sbjct 419 ALPGAVELAVELAED---DGGFDGGMVSGAGVLITGSVVTAGEARTLFGKDP 467 >gi|172041054|ref|YP_001800768.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium urealyticum DSM 7109] gi|171852358|emb|CAQ05334.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium urealyticum DSM 7109] Length=545 Score = 523 bits (1347), Expect = 3e-146, Method: Compositional matrix adjust. Identities = 276/473 (59%), Positives = 349/473 (74%), Gaps = 14/473 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 T +++A L VE L+QRWPET+IDPSL RI LMDLLG+P+RS+ +I +AGTNGKTSV Sbjct 82 TEEDLADLAAVEAELNQRWPETKIDPSLERIEMLMDLLGNPERSFATIQVAGTNGKTSVV 141 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+++L+ A HRRTGRTTSPHLQ ERI++DG+PI P Y+ +REI+P+V ++D +S Sbjct 142 RMIESLLRAFHRRTGRTTSPHLQLVTERIAVDGEPIHPQDYIRMWREIQPMVEMVDAKST 201 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A +GGP MSKFEVL A+A++AFADAPVDVAV+E GMGG WDATNV+N+ V+VITPI + Sbjct 202 A---EGGPQMSKFEVLVALAYSAFADAPVDVAVIETGMGGTWDATNVVNSDVSVITPIGM 258 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS-----PDTVAVIGRQVPKVMEVLLAESVRADA 254 DH D+LG + IAGEKAGII D P+ +A+I Q P+ M VLL +V DA Sbjct 259 DHTDFLGDTLTEIAGEKAGIIKSRWDREDLLTPPENIAIISEQEPEAMRVLLERAVEVDA 318 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 +VAR +EF + +AVGGQ L ++GL G Y DI+LPL GEHQA NA ALA+VEAFFG Sbjct 319 AVARAGAEFGAVESTVAVGGQRLTIKGLAGTYDDIFLPLSGEHQARNAATALAAVEAFFG 378 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AG RQLD D VR GFA VTSPGRLER+R+ P+VFIDA+HNP GA+ALA+ + +FDFR Sbjct 379 AGGDRQLDVDKVREGFATVTSPGRLERVRATPSVFIDASHNPHGAAALAKAVDRDFDFRR 438 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 L+GV++VLGDKD GILAALEPV D VV+T SPRAL V+ LA A + FG +RV AE Sbjct 439 LIGVVAVLGDKDARGILAALEPVLDDVVITEVQSPRALPVDVLAEYARDAFGEERVHVAE 498 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 L A++ A L +D +D +AG G+++TGSVVTAG ARTLF + P+ Sbjct 499 QLPTAVETAIQLAED-DSDGMLAG-----AGVLVTGSVVTAGEARTLFAKKPE 545 >gi|337291358|ref|YP_004630379.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium ulcerans BR-AD22] gi|334699664|gb|AEG84460.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium ulcerans BR-AD22] Length=520 Score = 518 bits (1335), Expect = 8e-145, Method: Compositional matrix adjust. Identities = 286/472 (61%), Positives = 347/472 (74%), Gaps = 16/472 (3%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 TP+++ASL VE LDQRW E +IDP+L R+ LMDLLG+P+R++ +IH+AGTNGKTS Sbjct 59 TPEDLASLALVEAELDQRWSEVKIDPTLDRVELLMDLLGNPERAFNTIHVAGTNGKTSTV 118 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM++AL+ A HRRTGRTTSPHLQ ERI+IDG PI P +YV + EI+P V ++D +S+ Sbjct 119 RMIEALMRAFHRRTGRTTSPHLQLVTERIAIDGAPIHPREYVRIWEEIKPYVEMVDAKSE 178 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 AS GGP MSKFEVLTAMA+AAFADAPVDVAVVEVGMGGRWDATNVINA VAV+ P+ + Sbjct 179 AS---GGPKMSKFEVLTAMAYAAFADAPVDVAVVEVGMGGRWDATNVINADVAVVMPVGL 235 Query 200 DHVDYLGADIAGIAGEKAGIITRAPD-----GSPDTVAVIGRQVPKVMEVLLAESVRADA 254 DH D+LG I IA EKAGII D PD VA++ Q PK M ++L ++V DA Sbjct 236 DHTDFLGESIEEIAAEKAGIIKSRWDVDDLLTPPDNVAIVAEQDPKAMNIILEQAVSVDA 295 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 SVAR +EF V+ IAVGGQ L ++GLGG Y+DI+LPL GEHQA NA ALA+VEAFFG Sbjct 296 SVARAGAEFGVIESTIAVGGQQLSIRGLGGDYTDIFLPLSGEHQARNAACALAAVEAFFG 355 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA RQLD D VR GFA+V SPGRLER+R+APTVFIDAAHNP GA+AL L +FDF Sbjct 356 AGAGRQLDQDTVREGFASVQSPGRLERVRTAPTVFIDAAHNPHGAAALGVALDRDFDFSR 415 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 L+GV++VL DKD G+L +LEP +VVT N SPRALD E LA A FG +RV A Sbjct 416 LIGVVAVLSDKDYRGVLRSLEPYLSEIVVTTNSSPRALDAEELADEARNIFGEERVHVAY 475 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 NL A+++A L +D D S G++ITGSVVTAG ARTLFG++P Sbjct 476 NLPGAVELAVELAEDT--------DIQSGAGVIITGSVVTAGEARTLFGKEP 519 >gi|257055281|ref|YP_003133113.1| folylpolyglutamate synthase/dihydrofolate synthase [Saccharomonospora viridis DSM 43017] gi|256585153|gb|ACU96286.1| folylpolyglutamate synthase/dihydrofolate synthase [Saccharomonospora viridis DSM 43017] Length=470 Score = 516 bits (1329), Expect = 3e-144, Method: Compositional matrix adjust. Identities = 276/460 (60%), Positives = 330/460 (72%), Gaps = 14/460 (3%) Query 27 LLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALV 86 L+ VE L++RWPET+I+PSLTRIS L +LLG PQR+YP IHIAGTNGK+S ARM++ L Sbjct 24 LISVEAELNRRWPETKIEPSLTRISTLANLLGDPQRAYPVIHIAGTNGKSSTARMIETLF 83 Query 87 TALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGG 146 + R GR TSPHLQ ERISIDG PISP YV TYR++EP VA++D + G Sbjct 84 MHMGLRVGRYTSPHLQLVTERISIDGVPISPETYVKTYRDVEPFVAMVDN----ATGPNE 139 Query 147 PAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLG 206 PAMSKFEVLT MAFAAFADAPV+VAV+E GMGGRWDATN+ +A ++VITPI IDH +YLG Sbjct 140 PAMSKFEVLTGMAFAAFADAPVEVAVLETGMGGRWDATNIADAQISVITPIGIDHTEYLG 199 Query 207 ADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVL 266 D IA EKAGII P +AV+ Q LL +V DA+VAR SEF VL Sbjct 200 EDRRSIATEKAGII------KPGGIAVLAEQPADAERALLERAVEVDATVARAGSEFGVL 253 Query 267 RRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAV 326 R IAVGGQ+L LQGLGGVY +I+LPLHG HQA NA LALA+VEAFFGAG +RQL+ + V Sbjct 254 NRDIAVGGQLLSLQGLGGVYDEIFLPLHGRHQADNAALALAAVEAFFGAGKERQLEVEVV 313 Query 327 RAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKD 386 R FAAV +PGRLER++++PTV IDAAHNP GA ALA T+ EF FR LV V+ VLGDKD Sbjct 314 REAFAAVQTPGRLERVKASPTVLIDAAHNPHGALALANTVDEEFAFRKLVAVVGVLGDKD 373 Query 387 VDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSL 446 G+L ALEPV +VVT N SPRAL + LA A FG +RV L AID A +L Sbjct 374 ATGVLEALEPVVSEIVVTQNSSPRALSADELATLALPIFGEERVTVEPRLDSAIDAAVTL 433 Query 447 VDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 V+ DP+ + S G+++TGSVVTAG ARTLFG++P Sbjct 434 VEQ-TDDPE---EPLSGGGVLVTGSVVTAGEARTLFGKEP 469 >gi|334697408|gb|AEG82205.1| dihydrofolate synthase / folylpolyglutamate synthase [Corynebacterium ulcerans 809] Length=520 Score = 516 bits (1329), Expect = 4e-144, Method: Compositional matrix adjust. Identities = 285/472 (61%), Positives = 346/472 (74%), Gaps = 16/472 (3%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 TP+++ASL VE LDQRW E +IDP+L R+ LMDLLG+P+R++ +IH+AGTNGKTS Sbjct 59 TPEDLASLALVEAELDQRWSEAKIDPTLDRVELLMDLLGNPERAFNTIHVAGTNGKTSTV 118 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM++AL+ A HRRTGRTTSPHLQ ERI+IDG PI P +YV + EI+P V ++D +S+ Sbjct 119 RMIEALMRAFHRRTGRTTSPHLQLVTERIAIDGAPIHPREYVRIWEEIKPYVEMVDAKSE 178 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 AS GP MSKFEVLTAMA+AAFADAPVDVAVVEVGMGGRWDATNVINA VAV+ P+ + Sbjct 179 AS---DGPKMSKFEVLTAMAYAAFADAPVDVAVVEVGMGGRWDATNVINADVAVVMPVGL 235 Query 200 DHVDYLGADIAGIAGEKAGIITRAPD-----GSPDTVAVIGRQVPKVMEVLLAESVRADA 254 DH D+LG I IA EKAGII D PD VA++ Q PK M ++L ++V DA Sbjct 236 DHTDFLGESIEEIAAEKAGIIKSRWDVDDLLTPPDNVAIVAEQDPKAMNIILEQAVSVDA 295 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 SVAR +EF V+ IAVGGQ L ++GLGG Y+DI+LPL GEHQA NA ALA+VEAFFG Sbjct 296 SVARSGAEFGVIESTIAVGGQQLSIRGLGGDYTDIFLPLSGEHQARNAACALAAVEAFFG 355 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA RQLD D VR GFA+V SPGRLER+R+APTVFIDAAHNP GA+AL L +FDF Sbjct 356 AGAGRQLDQDTVREGFASVQSPGRLERVRTAPTVFIDAAHNPHGAAALGVALDRDFDFSR 415 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 L+GV++VL DKD G+L +LEP +VVT N SPRALD E LA A FG +RV A Sbjct 416 LIGVVAVLSDKDYRGVLRSLEPYLSEIVVTTNSSPRALDAEELADEARNIFGEERVHVAY 475 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 NL A+++A L +D D S G++ITGSVVTAG ARTLFG++P Sbjct 476 NLPGAVELAVELAEDT--------DIQSGAGVIITGSVVTAGEARTLFGKEP 519 >gi|225021675|ref|ZP_03710867.1| hypothetical protein CORMATOL_01703 [Corynebacterium matruchotii ATCC 33806] gi|224945666|gb|EEG26875.1| hypothetical protein CORMATOL_01703 [Corynebacterium matruchotii ATCC 33806] Length=494 Score = 510 bits (1313), Expect = 2e-142, Method: Compositional matrix adjust. Identities = 292/472 (62%), Positives = 349/472 (74%), Gaps = 16/472 (3%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 T ++A+L +VE LDQRW ET IDP+L+R+ LMDLLG+P+RS+ +IH+AGTNGKTS Sbjct 33 TAADMAALAEVEAELDQRWNETTIDPTLSRMELLMDLLGNPERSFATIHVAGTNGKTSTV 92 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+++L+ A HRRTGRTTSPHLQ ERI+IDG+P+ P YV +REI+P V + D +S Sbjct 93 RMIESLMRAFHRRTGRTTSPHLQLVTERIAIDGRPLHPQDYVRIWREIQPYVEMADAES- 151 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A +GGP +SKFEVLTAMA+AAFADAPVDVAVVEVG+GGRWDATNVINA VAVITPI + Sbjct 152 --AKQGGPRLSKFEVLTAMAYAAFADAPVDVAVVEVGLGGRWDATNVINADVAVITPIGL 209 Query 200 DHVDYLGADIAGIAGEKAGIITRAPD-----GSPDTVAVIGRQVPKVMEVLLAESVRADA 254 DH+DYLG IA IA EKAGII + D PD VAVIG Q P + V+L +V DA Sbjct 210 DHMDYLGDTIAEIAAEKAGIIKQRWDLDDLLTPPDNVAVIGEQDPAALTVVLERAVATDA 269 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 +VAR EF V+ IAVGGQ + L+GLGG Y DI+LPL G HQAHNA +ALA+VEAFFG Sbjct 270 AVARYGMEFGVVESSIAVGGQQVTLRGLGGEYPDIFLPLSGAHQAHNAAVALAAVEAFFG 329 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA R LD D VR GFAAV SPGRLER+RSAPTVF+DAAHNP GA ALAQ L +FDF Sbjct 330 AGAGRSLDIDVVREGFAAVESPGRLERVRSAPTVFLDAAHNPHGARALAQALERDFDFTR 389 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 LVGV+SVLGDKDV GIL LEP +VVT N SPR L E LA A E FG +RV A+ Sbjct 390 LVGVVSVLGDKDVRGILRELEPCLHELVVTQNTSPRVLPAEELADIAREIFGEERVHVAQ 449 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 +L A+++A L +D + S G++ITGSVVTAG ARTLFG++P Sbjct 450 DLPGAVELAVELAEDT--------EVQSGAGVIITGSVVTAGEARTLFGKEP 493 >gi|213966174|ref|ZP_03394360.1| FolC bifunctional protein [Corynebacterium amycolatum SK46] gi|213951189|gb|EEB62585.1| FolC bifunctional protein [Corynebacterium amycolatum SK46] Length=572 Score = 508 bits (1308), Expect = 9e-142, Method: Compositional matrix adjust. Identities = 287/473 (61%), Positives = 344/473 (73%), Gaps = 12/473 (2%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 T +E+ L +VE LDQRWPET+IDPSL RI LMD+LG P+R+ P IH+AGTNGKTS Sbjct 107 TAEELRELAEVEAELDQRWPETKIDPSLERIEMLMDILGHPERATPVIHVAGTNGKTSTV 166 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+++LV AL RRTGRTTSPHLQ ERI+IDG+PI P YV +REI+P V ++D +S Sbjct 167 RMIESLVRALGRRTGRTTSPHLQLVTERIAIDGQPIHPRDYVRIWREIQPYVEMVDAKS- 225 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 A KGGP MSKFEVLTAMA+AAFADAPVDVAVVEVGMGG WDATNV+ A VAVI PI + Sbjct 226 --AEKGGPQMSKFEVLTAMAYAAFADAPVDVAVVEVGMGGTWDATNVVEADVAVICPIGL 283 Query 200 DHVDYLGADIAGIAGEKAGIITRAPDGS-----PDTVAVIGRQVPKVMEVLLAESVRADA 254 DH +YLG +A IA EKAGII + PD VA++G Q P+ M+V+L +V DA Sbjct 284 DHTEYLGDTLAEIASEKAGIIKSRWNKDDLLTPPDNVAIVGEQEPEAMDVVLRRAVEMDA 343 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 SVAR E+ V+ Q+AVGGQ L L+GL G Y DI+LPLHG HQA NA ALA+VEAFFG Sbjct 344 SVARAGVEYGVVSHQLAVGGQNLTLKGLVGEYDDIHLPLHGPHQARNAATALAAVEAFFG 403 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AG R L+ DAVR GFA V SPGRLER+RS PTVFIDAAHNP GA AL L+ EFDFR Sbjct 404 AGPGRPLNIDAVREGFATVASPGRLERVRSTPTVFIDAAHNPHGARALRTALSAEFDFRR 463 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 ++GVLSVLG+KD G+L LEP F+ VV+T N SPRAL + LA A E FG +RV Sbjct 464 VIGVLSVLGEKDARGLLVELEPYFEEVVITQNTSPRALHYDDLADLAEEIFGEERVHRVP 523 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ 487 L A+++A +L A + D S +G+++TGSVVTAG ARTLFG+DPQ Sbjct 524 TLPSAVELAVAL----AEETDTGDGIVSGSGVIVTGSVVTAGEARTLFGKDPQ 572 >gi|305680780|ref|ZP_07403587.1| bifunctional protein FolC [Corynebacterium matruchotii ATCC 14266] gi|305658985|gb|EFM48485.1| bifunctional protein FolC [Corynebacterium matruchotii ATCC 14266] Length=493 Score = 506 bits (1303), Expect = 3e-141, Method: Compositional matrix adjust. Identities = 291/472 (62%), Positives = 347/472 (74%), Gaps = 16/472 (3%) Query 20 TPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVA 79 T ++A+L +VE LDQRW ET IDP+L+R+ LMDLLG+P+RS+ +IH+AGTNGKTS Sbjct 32 TAADMAALAEVEAELDQRWNETTIDPTLSRMELLMDLLGNPERSFATIHVAGTNGKTSTV 91 Query 80 RMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQ 139 RM+++L+ A HRRTGRTTSPHLQ ERI+IDG+P+ P YV +REI+P V + D +S Sbjct 92 RMIESLMRAFHRRTGRTTSPHLQLVTERIAIDGRPLHPQDYVRIWREIQPYVEMADAES- 150 Query 140 ASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISI 199 +GGP +SKFEVLTAMA+AAFADAPVDVAVVEVG+GGRWDATNVINA VAVITPI + Sbjct 151 --VKQGGPRLSKFEVLTAMAYAAFADAPVDVAVVEVGLGGRWDATNVINADVAVITPIGL 208 Query 200 DHVDYLGADIAGIAGEKAGIITRAPD-----GSPDTVAVIGRQVPKVMEVLLAESVRADA 254 DH+DYLG IA IA EKAGII + D PD VAVIG Q P + V+L +V DA Sbjct 209 DHMDYLGDTIAEIAAEKAGIIKQRWDLDDLLTPPDNVAVIGEQDPAALTVVLERAVATDA 268 Query 255 SVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFG 314 +VAR EF V+ IAVGGQ + L+GLGG Y DI+LPL G HQAHNA +ALA+VEAFFG Sbjct 269 AVARYGMEFGVVESSIAVGGQQVTLRGLGGEYPDIFLPLSGAHQAHNAAVALAAVEAFFG 328 Query 315 AGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRF 374 AGA R LD D VR GFAAV SPGRLER+RSAPTVF+DAAHNP GA ALAQ L +FDF Sbjct 329 AGAGRSLDLDVVREGFAAVESPGRLERVRSAPTVFLDAAHNPHGARALAQALERDFDFTR 388 Query 375 LVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAE 434 LVGV+SVLGDKDV GIL LEP +VVT N SPR L E LA A E FG +RV A+ Sbjct 389 LVGVVSVLGDKDVRGILRELEPCLHELVVTQNTSPRVLPAEELADIAREIFGEERVHVAQ 448 Query 435 NLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 +L A+ +A L +D + S G++ITGSVVTAG ARTLFG++P Sbjct 449 DLPGAVALAVELAEDT--------EVQSGAGVIITGSVVTAGEARTLFGKEP 492 >gi|256375307|ref|YP_003098967.1| FolC bifunctional protein [Actinosynnema mirum DSM 43827] gi|255919610|gb|ACU35121.1| FolC bifunctional protein [Actinosynnema mirum DSM 43827] Length=452 Score = 504 bits (1298), Expect = 1e-140, Method: Compositional matrix adjust. Identities = 274/466 (59%), Positives = 335/466 (72%), Gaps = 19/466 (4%) Query 21 PDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVAR 80 P + L VE LD+RWPET+I+PSL RI AL+D+LG PQ++YP IH+ GTNGKTS AR Sbjct 5 PGALGILSVVEAELDKRWPETKIEPSLDRIRALVDVLGEPQKAYPVIHVGGTNGKTSTAR 64 Query 81 MVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQA 140 MV+AL+T + RTGR TSPHLQ ERIS+DG PISP QYV YR+++P V+++D Sbjct 65 MVEALLTRVGLRTGRYTSPHLQLATERISVDGAPISPEQYVEAYRDVKPYVSIVDS---- 120 Query 141 SAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISID 200 +G MSKFEVLT MAFAAFA+ PVDVAVVEVG+GG WDATNV + VAVITPI ID Sbjct 121 ---RGDVPMSKFEVLTGMAFAAFAETPVDVAVVEVGLGGSWDATNVADGRVAVITPIGID 177 Query 201 HVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVARED 260 HV++LG D+AGIA EKAGII P + V+ +Q P+ + LL DA+VAR+ Sbjct 178 HVEFLGDDLAGIAEEKAGII------KPGSTVVLAQQRPEAEQALLRRVAEVDATVARQG 231 Query 261 SEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQ 320 SEF VLRR +AVGGQ+L+LQGLGGVY +++LPLHG HQA NA LALA+VEAFFGAG QRQ Sbjct 232 SEFLVLRRDVAVGGQMLRLQGLGGVYDEVFLPLHGAHQAANASLALAAVEAFFGAGPQRQ 291 Query 321 LDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLS 380 LD +AVR FA V SPGRLER+R+AP V +DAAHNP GA ALA+ L EF FR L+ V+ Sbjct 292 LDVEAVREAFAGVESPGRLERLRAAPAVLVDAAHNPHGAEALAKALDEEFGFRRLIAVVG 351 Query 381 VLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAI 440 V+ DKD GIL ALEP VV+T N SPRA+D + LA A FG DR+ NL DAI Sbjct 352 VMSDKDAVGILTALEPRVAEVVLTQNSSPRAMDADHLAGVALPIFGEDRIVVQPNLADAI 411 Query 441 DVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDP 486 + A + +D D V+G G+++TGSVVTAG AR LFG++P Sbjct 412 EDAVRMAED-TEDGLVSGG-----GVIVTGSVVTAGQARALFGKEP 451 Lambda K H 0.317 0.133 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 1038195005428 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40