BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2458 Length=302 Score E Sequences producing significant alignments: (Bits) Value gi|15609595|ref|NP_216974.1| homocysteine methyltransferase [Myc... 595 2e-168 gi|31793639|ref|NP_856132.1| homocysteine methyltransferase [Myc... 592 3e-167 gi|15841982|ref|NP_337019.1| homocysteine methyltransferase [Myc... 590 7e-167 gi|298525936|ref|ZP_07013345.1| homocysteine methyltransferase [... 588 2e-166 gi|240170930|ref|ZP_04749589.1| homocysteine methyltransferase [... 462 4e-128 gi|15827776|ref|NP_302039.1| homocysteine methyltransferase [Myc... 447 8e-124 gi|342857855|ref|ZP_08714511.1| homocysteine methyltransferase [... 421 5e-116 gi|336458287|gb|EGO37267.1| homocysteine/selenocysteine methylas... 420 2e-115 gi|254774531|ref|ZP_05216047.1| homocysteine methyltransferase [... 419 3e-115 gi|41408377|ref|NP_961213.1| homocysteine methyltransferase [Myc... 418 5e-115 gi|254821426|ref|ZP_05226427.1| homocysteine methyltransferase [... 406 2e-111 gi|118466904|ref|YP_880942.1| homocysteine methyltransferase [My... 382 2e-104 gi|257057675|ref|YP_003135507.1| homocysteine methyltransferase ... 378 8e-103 gi|333990089|ref|YP_004522703.1| homocysteine methyltransferase ... 354 8e-96 gi|333919400|ref|YP_004492981.1| homocysteine methyltransferase ... 350 2e-94 gi|134100425|ref|YP_001106086.1| homocysteine methyltransferase ... 342 3e-92 gi|337768639|emb|CCB77352.1| Homocysteine S-methyltransferase 4 ... 326 2e-87 gi|297203247|ref|ZP_06920644.1| homocysteine methyltransferase [... 322 4e-86 gi|290956464|ref|YP_003487646.1| transferase [Streptomyces scabi... 320 2e-85 gi|345009879|ref|YP_004812233.1| homocysteine S-methyltransferas... 316 3e-84 gi|345002614|ref|YP_004805468.1| homocysteine S-methyltransferas... 314 1e-83 gi|302557562|ref|ZP_07309904.1| homocysteine S-methyltransferase... 313 1e-83 gi|32141288|ref|NP_733689.1| homocysteine methyltransferase [Str... 313 2e-83 gi|320007976|gb|ADW02826.1| homocysteine S-methyltransferase [St... 313 3e-83 gi|289768223|ref|ZP_06527601.1| homocysteine methyltransferase [... 311 6e-83 gi|297191400|ref|ZP_06908798.1| homocysteine methyltransferase [... 310 1e-82 gi|291454931|ref|ZP_06594321.1| homocysteine methyltransferase [... 308 8e-82 gi|291436474|ref|ZP_06575864.1| homocysteine methyltransferase [... 306 3e-81 gi|239991425|ref|ZP_04712089.1| homocysteine methyltransferase [... 305 5e-81 gi|291448422|ref|ZP_06587812.1| homocysteine methyltransferase [... 305 6e-81 gi|302555024|ref|ZP_07307366.1| homocysteine methyltransferase [... 303 3e-80 gi|328885829|emb|CCA59068.1| Homocysteine S-methyltransferase [S... 303 3e-80 gi|302541970|ref|ZP_07294312.1| homocysteine S-methyltransferase... 301 6e-80 gi|29828653|ref|NP_823287.1| homocysteine methyltransferase [Str... 299 4e-79 gi|297156629|gb|ADI06341.1| homocysteine methyltransferase [Stre... 293 2e-77 gi|148274014|ref|YP_001223575.1| homocysteine methyltransferase ... 293 2e-77 gi|258654689|ref|YP_003203845.1| homocysteine methyltransferase ... 290 2e-76 gi|329940276|ref|ZP_08289558.1| homocysteine methyltransferase [... 290 2e-76 gi|170783269|ref|YP_001711603.1| homocysteine methyltransferase ... 289 4e-76 gi|311894980|dbj|BAJ27388.1| putative homocysteine S-methyltrans... 286 2e-75 gi|182435369|ref|YP_001823088.1| homocysteine methyltransferase ... 279 3e-73 gi|254390558|ref|ZP_05005773.1| homocysteine methyltransferase [... 275 8e-72 gi|326776008|ref|ZP_08235273.1| Homocysteine S-methyltransferase... 274 1e-71 gi|295835182|ref|ZP_06822115.1| homocysteine S-methyltransferase... 271 7e-71 gi|326333481|ref|ZP_08199723.1| homocysteine S-methyltransferase... 271 1e-70 gi|302523430|ref|ZP_07275772.1| homocysteine methyltransferase [... 270 2e-70 gi|332529802|ref|ZP_08405756.1| homocysteine methyltransferase [... 270 2e-70 gi|336120795|ref|YP_004575581.1| homocysteine S-methyltransferas... 268 9e-70 gi|318058173|ref|ZP_07976896.1| homocysteine methyltransferase [... 266 3e-69 gi|261822177|ref|YP_003260283.1| homocysteine methyltransferase ... 265 6e-69 >gi|15609595|ref|NP_216974.1| homocysteine methyltransferase [Mycobacterium tuberculosis H37Rv] gi|148662293|ref|YP_001283816.1| homocysteine methyltransferase [Mycobacterium tuberculosis H37Ra] gi|167969783|ref|ZP_02552060.1| homocysteine methyltransferase [Mycobacterium tuberculosis H37Ra] 10 more sequence titles Length=302 Score = 595 bits (1535), Expect = 2e-168, Method: Compositional matrix adjust. Identities = 301/302 (99%), Positives = 302/302 (100%), Gaps = 0/302 (0%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 +ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT Sbjct 1 MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS Sbjct 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS Sbjct 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN Sbjct 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP Sbjct 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 Query 301 RG 302 RG Sbjct 301 RG 302 >gi|31793639|ref|NP_856132.1| homocysteine methyltransferase [Mycobacterium bovis AF2122/97] gi|121638341|ref|YP_978565.1| homocysteine methyltransferase [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|148823658|ref|YP_001288412.1| homocysteine methyltransferase [Mycobacterium tuberculosis F11] 56 more sequence titles Length=302 Score = 592 bits (1525), Expect = 3e-167, Method: Compositional matrix adjust. Identities = 300/302 (99%), Positives = 301/302 (99%), Gaps = 0/302 (0%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 +ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT Sbjct 1 MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS Sbjct 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS Sbjct 121 EYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN Sbjct 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP Sbjct 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 Query 301 RG 302 RG Sbjct 301 RG 302 >gi|15841982|ref|NP_337019.1| homocysteine methyltransferase [Mycobacterium tuberculosis CDC1551] gi|254232592|ref|ZP_04925919.1| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis C] gi|254365234|ref|ZP_04981280.1| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis str. Haarlem] gi|13882256|gb|AAK46833.1| homocysteine S-methyltransferase [Mycobacterium tuberculosis CDC1551] gi|124601651|gb|EAY60661.1| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis C] gi|134150748|gb|EBA42793.1| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis str. Haarlem] gi|323718964|gb|EGB28114.1| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis CDC1551A] Length=302 Score = 590 bits (1522), Expect = 7e-167, Method: Compositional matrix adjust. Identities = 299/302 (99%), Positives = 301/302 (99%), Gaps = 0/302 (0%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 +ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT Sbjct 1 MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS Sbjct 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YGLSVAALMKWHLPRLEVLVDAGADMLAL+TIPDIDEAEALVNLVRRLATPAWLS Sbjct 121 EYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALKTIPDIDEAEALVNLVRRLATPAWLS 180 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN Sbjct 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP Sbjct 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 Query 301 RG 302 RG Sbjct 301 RG 302 >gi|298525936|ref|ZP_07013345.1| homocysteine methyltransferase [Mycobacterium tuberculosis 94_M4241A] gi|308377015|ref|ZP_07440877.2| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis SUMu008] gi|298495730|gb|EFI31024.1| homocysteine methyltransferase [Mycobacterium tuberculosis 94_M4241A] gi|308349196|gb|EFP38047.1| homocysteine S-methyltransferase mmuM [Mycobacterium tuberculosis SUMu008] Length=300 Score = 588 bits (1517), Expect = 2e-166, Method: Compositional matrix adjust. Identities = 298/300 (99%), Positives = 299/300 (99%), Gaps = 0/300 (0%) Query 3 LVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS 62 +VSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS Sbjct 1 MVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS 60 Query 63 YQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEY 122 YQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEY Sbjct 61 YQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEY 120 Query 123 RGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYT 182 RG YGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYT Sbjct 121 RGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYT 180 Query 183 INGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSG 242 INGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSG Sbjct 181 INGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSG 240 Query 243 EGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG 302 EGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG Sbjct 241 EGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG 300 >gi|240170930|ref|ZP_04749589.1| homocysteine methyltransferase [Mycobacterium kansasii ATCC 12478] Length=292 Score = 462 bits (1188), Expect = 4e-128, Method: Compositional matrix adjust. Identities = 241/295 (82%), Positives = 253/295 (86%), Gaps = 5/295 (1%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 + L +DSV+ISDGGLATELEARGHDL+D LWSARLL DAP ITAVH AYFRAGA IATT Sbjct 1 MRLAADSVVISDGGLATELEARGHDLTDRLWSARLLTDAPQEITAVHAAYFRAGATIATT 60 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 ASYQASFEGFAA IGHD A LLRRSVELA ARDEVG GL VAASVGPYGAALADGS Sbjct 61 ASYQASFEGFAAHRIGHDKAVALLRRSVELAANARDEVGAAGLLVAASVGPYGAALADGS 120 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YGLSV AL KWH PRLEVL AGAD+LA+ETIPD+DEAEALVNLVR++ PAWLS Sbjct 121 EYRGRYGLSVRALTKWHRPRLEVLAAAGADVLAVETIPDVDEAEALVNLVRQVGVPAWLS 180 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 YTI GTRTRAGQPL DAFAVAAGVPEIVAVGVNCCAPDDVL AI A A GKPVIVYPN Sbjct 181 YTIEGTRTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLAAI--ACADVGKPVIVYPN 238 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 SGE WD RRRAWVGPRRF SG+LAR+WVAAGARIVGGCCRV P DIAEI RA+ Sbjct 239 SGEHWDSRRRAWVGPRRF---SGELARQWVAAGARIVGGCCRVGPADIAEIRRAV 290 >gi|15827776|ref|NP_302039.1| homocysteine methyltransferase [Mycobacterium leprae TN] gi|221230253|ref|YP_002503669.1| homocysteine methyltransferase [Mycobacterium leprae Br4923] gi|13093328|emb|CAC30428.1| possible transferase [Mycobacterium leprae] gi|219933360|emb|CAR71572.1| possible transferase [Mycobacterium leprae Br4923] Length=293 Score = 447 bits (1151), Expect = 8e-124, Method: Compositional matrix adjust. Identities = 231/293 (79%), Positives = 249/293 (85%), Gaps = 7/293 (2%) Query 5 SDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQ 64 S+SVLI+DGGLATELEARG+DLSDPLWSARLL DAP I AVH AYFRAGA IATT SYQ Sbjct 7 SESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIATTVSYQ 66 Query 65 ASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRG 124 ASFEGFAARGIG D A L+RRSV LA AARDE+ GGL VAASVGPYGAALADGSEYRG Sbjct 67 ASFEGFAARGIGRDQAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALADGSEYRG 126 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSVAAL +WH PRLEVL DAGAD+LALETIPDIDEAEALV+LVR + PAWLSYTIN Sbjct 127 RYGLSVAALARWHRPRLEVLADAGADVLALETIPDIDEAEALVDLVRSVGVPAWLSYTIN 186 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 GTRTRAGQPL +AFAVAAGVP+IVAVGVNCCAPDDVL AI +A+ GKP+IVYPNSGE Sbjct 187 GTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAI--QIANIGKPIIVYPNSGER 244 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTT 297 WD R W GPRRF S QLA +W AAGARIVGGCCRVRP DIAE+ +AL + Sbjct 245 WD--YRTWTGPRRF---SAQLALQWTAAGARIVGGCCRVRPADIAELTKALAS 292 >gi|342857855|ref|ZP_08714511.1| homocysteine methyltransferase [Mycobacterium colombiense CECT 3035] gi|342135188|gb|EGT88354.1| homocysteine methyltransferase [Mycobacterium colombiense CECT 3035] Length=294 Score = 421 bits (1083), Expect = 5e-116, Method: Compositional matrix adjust. Identities = 218/289 (76%), Positives = 236/289 (82%), Gaps = 4/289 (1%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGLATELEARGHDLSDPLWSA LL DAP I AVH AYFRAGA+IATTASYQ SFE Sbjct 1 MLLDGGLATELEARGHDLSDPLWSAGLLADAPRDIAAVHAAYFRAGARIATTASYQGSFE 60 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGL 128 GFAARG + LLRRSVELAQAARDE G GL VAAS+GPYGAALADGSEYRG YGL Sbjct 61 GFAARGFDRRETAGLLRRSVELAQAARDEAGGAGLLVAASIGPYGAALADGSEYRGRYGL 120 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 SVAAL +WH PRLE+L DAGAD+LA ET+PD+DEA+ALV LVR + PAWLSYTI+G RT Sbjct 121 SVAALARWHRPRLEILADAGADLLACETVPDVDEAQALVELVRSVGKPAWLSYTIDGDRT 180 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQPL DAFAVAAGV EIVA+GVNCCAP DVLPAIA A A GKPVI YPNSGE WDG Sbjct 181 RAGQPLADAFAVAAGVDEIVAIGVNCCAPGDVLPAIARAAA-VGKPVIAYPNSGERWDGL 239 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTT 297 R W+GP RF S QLA++W AAGARIVGGCCRV P +IAEI RA Sbjct 240 RHTWIGPSRF---SAQLAKQWTAAGARIVGGCCRVGPAEIAEIRRACNQ 285 >gi|336458287|gb|EGO37267.1| homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Mycobacterium avium subsp. paratuberculosis S397] Length=306 Score = 420 bits (1079), Expect = 2e-115, Method: Compositional matrix adjust. Identities = 223/292 (77%), Positives = 235/292 (81%), Gaps = 6/292 (2%) Query 5 SDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQ 64 SD VL+ DGGLATELEARGHDLSDPLWSARLL DAP I AVH AYFRAGA IATTASYQ Sbjct 11 SDPVLL-DGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGAMIATTASYQ 69 Query 65 ASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRG 124 ASFEGFAARGI D LLRRSVELA+AARDE GV G VAASVGPYGAALADGSEYRG Sbjct 70 ASFEGFAARGISRSDTAGLLRRSVELAKAARDEAGVAG-HVAASVGPYGAALADGSEYRG 128 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YG+SV L WH PRLEVL A AD+LA+ETIPD+DEAEALVNLVR L PAWLSYTI+ Sbjct 129 RYGISVRQLEDWHRPRLEVLAGADADVLAVETIPDVDEAEALVNLVRSLGVPAWLSYTID 188 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G TRAGQPL DAFAVAAGVPEIVAVGVNCCAPDDVLP I A A GKPVIVYPNSGE Sbjct 189 GAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAA-IGKPVIVYPNSGEH 247 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 WD R W GP RFS LA W++AGARIVGGCC+VRP DIA + RA + Sbjct 248 WDALRHNWTGPSRFSAP---LAARWISAGARIVGGCCQVRPTDIAAVRRACS 296 >gi|254774531|ref|ZP_05216047.1| homocysteine methyltransferase [Mycobacterium avium subsp. avium ATCC 25291] Length=291 Score = 419 bits (1076), Expect = 3e-115, Method: Compositional matrix adjust. Identities = 222/288 (78%), Positives = 236/288 (82%), Gaps = 7/288 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGLATELEARGHDLSDPLWSARLL DAP I AVH AYFRAGA IATTASYQASFE Sbjct 1 MLLDGGLATELEARGHDLSDPLWSARLLADAPQEIGAVHAAYFRAGAMIATTASYQASFE 60 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGL 128 GFAARGI D LLRRSVELA+AARDE GV G VAASVGPYGAALADGSEYRG YGL Sbjct 61 GFAARGISRSDTAGLLRRSVELAKAARDEAGVAGY-VAASVGPYGAALADGSEYRGRYGL 119 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 SV L WH PRLEVL DA AD+LA+ETIPD+DEAEALVNLVR L PAWLSYTI+G T Sbjct 120 SVRQLEDWHRPRLEVLADADADVLAVETIPDVDEAEALVNLVRSLGVPAWLSYTIDGAHT 179 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQPL DAFAVAAGVPEIVAVGVNCCAPDDVLPAI A A GKPVIVYPNSGE WDG Sbjct 180 RAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPAIGPARA-VGKPVIVYPNSGEHWDG- 237 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 R W G +F S +LA +W++AGARIVGGCCRVRP DIA + RA + Sbjct 238 -RVWTGRSKF---SAELASQWISAGARIVGGCCRVRPTDIAAVRRACS 281 >gi|41408377|ref|NP_961213.1| homocysteine methyltransferase [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396733|gb|AAS04596.1| hypothetical protein MAP_2279 [Mycobacterium avium subsp. paratuberculosis K-10] Length=306 Score = 418 bits (1075), Expect = 5e-115, Method: Compositional matrix adjust. Identities = 222/292 (77%), Positives = 235/292 (81%), Gaps = 6/292 (2%) Query 5 SDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQ 64 SD VL+ DGGLATELEARGHDLSDPLWSARLL DAP I AVH AYFRAGA IATTASYQ Sbjct 11 SDPVLL-DGGLATELEARGHDLSDPLWSARLLADAPQEIVAVHAAYFRAGAMIATTASYQ 69 Query 65 ASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRG 124 ASFEGFAARGI D LLRRSVELA+AARDE GV G VAASVGPYGAALADGSEYRG Sbjct 70 ASFEGFAARGISRSDTAGLLRRSVELAKAARDEAGVAG-HVAASVGPYGAALADGSEYRG 128 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YG+SV L WH PRLEVL A AD+LA+ETIPD+DEAEALVNLVR L PAWLSYTI+ Sbjct 129 RYGISVRQLEDWHRPRLEVLAGADADVLAVETIPDVDEAEALVNLVRSLGVPAWLSYTID 188 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G TRAGQPL DAFAVAAGVPEIVAVGVNCCAPDDVLP I A A GKPVIVYPNSGE Sbjct 189 GAHTRAGQPLADAFAVAAGVPEIVAVGVNCCAPDDVLPTIEIAAA-IGKPVIVYPNSGEH 247 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 W+ R W GP RF S LA W++AGARIVGGCC+VRP DIA + RA + Sbjct 248 WNALRHNWTGPSRF---SAPLAARWISAGARIVGGCCQVRPTDIAAVRRACS 296 >gi|254821426|ref|ZP_05226427.1| homocysteine methyltransferase [Mycobacterium intracellulare ATCC 13950] Length=308 Score = 406 bits (1044), Expect = 2e-111, Method: Compositional matrix adjust. Identities = 221/287 (78%), Positives = 242/287 (85%), Gaps = 7/287 (2%) Query 5 SDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQ 64 S +VL+ DGGLATELEARGHDLSD LWSARLL DAP I AVH AYFRAGA IATTASYQ Sbjct 11 SGTVLL-DGGLATELEARGHDLSDRLWSARLLADAPREIVAVHAAYFRAGATIATTASYQ 69 Query 65 ASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRG 124 ASFEGFAARG+ + +LLRRSVELA+AARDE G GL VAASVGPYGAALADGSEYRG Sbjct 70 ASFEGFAARGLDRRETDLLLRRSVELAKAARDEAGAAGLLVAASVGPYGAALADGSEYRG 129 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSV AL +WH PRLE L DAGAD+LA ET+PD+DEAEALV++VR + PAWLSYTI+ Sbjct 130 RYGLSVGALARWHRPRLETLADAGADVLACETVPDVDEAEALVDVVRSVGMPAWLSYTID 189 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQPLT+AFAVAAGV EIVAVGVNCCAPDDVLPAIA A + GKPVIVYPNSGE Sbjct 190 GARTRAGQPLTEAFAVAAGVDEIVAVGVNCCAPDDVLPAIASA-SEIGKPVIVYPNSGER 248 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 WDG RAWVGPR F+ LA +WV+AGARIVGGCCRV P+DIAE+ Sbjct 249 WDG--RAWVGPRTFATG---LAAQWVSAGARIVGGCCRVGPVDIAEL 290 >gi|118466904|ref|YP_880942.1| homocysteine methyltransferase [Mycobacterium avium 104] gi|118168191|gb|ABK69088.1| homocysteine S-methyltransferase [Mycobacterium avium 104] Length=291 Score = 382 bits (982), Expect = 2e-104, Method: Compositional matrix adjust. Identities = 221/288 (77%), Positives = 234/288 (82%), Gaps = 7/288 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGLATELEARGHDLSDPLWSARLL DAP I AVH AYFRAGA IATTASYQASFE Sbjct 1 MLLDGGLATELEARGHDLSDPLWSARLLADAPQEIGAVHAAYFRAGAMIATTASYQASFE 60 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGL 128 GFAARGI D LLRRSVELA+AARDE GV G VAASVGPYGAALADGSEYRG YGL Sbjct 61 GFAARGISRSDTAGLLRRSVELAKAARDEAGVAGY-VAASVGPYGAALADGSEYRGRYGL 119 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 SV L WH PRLEVL DA AD+LA ETIPD+DEAEALVNLVR L PAWLSYTI+G T Sbjct 120 SVRQLEDWHRPRLEVLADADADVLAAETIPDVDEAEALVNLVRSLGVPAWLSYTIDGAHT 179 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQPL DAFAVAAG PEIVA GVNCCAPDDVLPAI A A GKPVIVYPNSGE WDG Sbjct 180 RAGQPLADAFAVAAGAPEIVAFGVNCCAPDDVLPAIGPARA-VGKPVIVYPNSGEHWDG- 237 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 RAW G +F S +LA +W++AGARIVGGCCRVRP DIA + RA + Sbjct 238 -RAWTGRSKF---SAELASQWISAGARIVGGCCRVRPTDIAAVRRACS 281 >gi|257057675|ref|YP_003135507.1| homocysteine methyltransferase [Saccharomonospora viridis DSM 43017] gi|256587547|gb|ACU98680.1| homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Saccharomonospora viridis DSM 43017] Length=295 Score = 378 bits (970), Expect = 8e-103, Method: Compositional matrix adjust. Identities = 199/289 (69%), Positives = 220/289 (77%), Gaps = 5/289 (1%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+SDGGLATELEARGHDL D LWSARLL+DAP I AVH A++ AGA IATTASYQASF Sbjct 10 LVSDGGLATELEARGHDLGDALWSARLLLDAPDEIVAVHRAFYEAGAVIATTASYQASFS 69 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS--VAASVGPYGAALADGSEYRGYY 126 GFA RGI D AT LLRRSVELA+ ARDE G VAASVGPYGAALADGSEYRG Y Sbjct 70 GFAERGIDRDTATTLLRRSVELARRARDEAPDDGRRRFVAASVGPYGAALADGSEYRGRY 129 Query 127 GLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGT 186 GLSVA L +WH PRLEVL + D+LALET+PDIDEAEALV V L PAWL+YT++G Sbjct 130 GLSVARLRRWHRPRLEVLAETSPDILALETVPDIDEAEALVEAVAGLGVPAWLTYTVDGE 189 Query 187 RTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWD 246 RTRAGQPLT+AFAVA P+IVAVGVNCC PDDV A+A A T KP++VYPNSGE WD Sbjct 190 RTRAGQPLTEAFAVAQSSPDIVAVGVNCCTPDDVSTALALAREVTTKPLVVYPNSGENWD 249 Query 247 GRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 RR W GP R+ S +LAR W A GA +VGGCCRV P DIA + L Sbjct 250 PVRRTWWGPSRY---SPELARRWTAEGAHVVGGCCRVGPADIARVADVL 295 >gi|333990089|ref|YP_004522703.1| homocysteine methyltransferase [Mycobacterium sp. JDM601] gi|333486057|gb|AEF35449.1| homocysteine methyltransferase [Mycobacterium sp. JDM601] Length=312 Score = 354 bits (909), Expect = 8e-96, Method: Compositional matrix adjust. Identities = 208/287 (73%), Positives = 227/287 (80%), Gaps = 11/287 (3%) Query 6 DSVLISDGGLATELEARGHDLS----DPLWSARLLVDAPHAITAVHTAYFRAGAQIATTA 61 D+V+++DGGLATELEARG DLS DPLWSARLL+DAP + AVH A+F AGA IATTA Sbjct 11 DTVIVADGGLATELEARGFDLSGDLSDPLWSARLLLDAPDDVAAVHAAFFAAGAAIATTA 70 Query 62 SYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSE 121 SYQASF+GFAARGI A LLRRSV+LA+ A G G VAASVGPYGAA ADGSE Sbjct 71 SYQASFDGFAARGIDRRTAERLLRRSVDLARLAGG--GARGHRVAASVGPYGAARADGSE 128 Query 122 YRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSY 181 Y G YGLSV+ L WH PRLEVL DAGAD+LALET+PD+DEAEAL+ LV PAWLSY Sbjct 129 YVGRYGLSVSELTAWHRPRLEVLADAGADVLALETVPDVDEAEALMRLVSEAGVPAWLSY 188 Query 182 TINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNS 241 TI GT TRAGQPLTDAFAVAAGVP+IVAVGVNCCAPDDVLPAI A TGKPVIVYPNS Sbjct 189 TIEGTSTRAGQPLTDAFAVAAGVPQIVAVGVNCCAPDDVLPAIEIAREITGKPVIVYPNS 248 Query 242 GEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDI 288 GE WDG R WVGP+ F S + A +WVAAGARIVGGCCRV P DI Sbjct 249 GESWDGHR--WVGPKTF---SARFAAQWVAAGARIVGGCCRVGPADI 290 >gi|333919400|ref|YP_004492981.1| homocysteine methyltransferase [Amycolicicoccus subflavus DQS3-9A1] gi|333481621|gb|AEF40181.1| homocysteine methyltransferase [Amycolicicoccus subflavus DQS3-9A1] Length=297 Score = 350 bits (897), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 184/288 (64%), Positives = 211/288 (74%), Gaps = 6/288 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGLAT LEARGH+L+ LWSARLL+D P I AVH A+F AGA IA TASYQASF Sbjct 13 LVCDGGLATALEARGHNLAGGLWSARLLLDTPDEIAAVHRAFFAAGADIAITASYQASFR 72 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGL 128 GFA GIG LLRRSV +A RDE G G VAAS+GPYGAA ADGSEY+G YGL Sbjct 73 GFANCGIGRRGTERLLRRSVRIAADVRDEFGRG--FVAASIGPYGAAAADGSEYKGRYGL 130 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 SV L WH PR E+L D GAD+LA+ETIPD+DEAEAL +L+ PAWLSYTI G RT Sbjct 131 SVRELRAWHRPRFEILADTGADVLAVETIPDLDEAEALASLISEFRVPAWLSYTIAGART 190 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQP++DAF VA+ + IVAVGVNCCAP DV+P I A H+GKPVIVYPNSGEGWD Sbjct 191 RAGQPVSDAFEVASEIDSIVAVGVNCCAPADVIPTIDTA-QHSGKPVIVYPNSGEGWDAE 249 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 W G F S +LAR+W AAGA+I+GGCCRV DIA++ AL+ Sbjct 250 AGRWTGKSEF---SVKLARQWAAAGAQIIGGCCRVGAGDIAQVASALS 294 >gi|134100425|ref|YP_001106086.1| homocysteine methyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|291007321|ref|ZP_06565294.1| homocysteine methyltransferase [Saccharopolyspora erythraea NRRL 2338] gi|133913048|emb|CAM03161.1| homocysteine S-methyltransferase [Saccharopolyspora erythraea NRRL 2338] Length=297 Score = 342 bits (878), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 185/295 (63%), Positives = 214/295 (73%), Gaps = 4/295 (1%) Query 2 ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTA 61 +L S + L+ DGGLATELEARGHDLSD LWSARLL DAP I A H A+FRAGA IATTA Sbjct 5 DLCSSAPLVLDGGLATELEARGHDLSDELWSARLLHDAPEEIVAAHEAFFRAGAVIATTA 64 Query 62 SYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS-VAASVGPYGAALADGS 120 SYQASF GF ARGIG DA L+RRSVELA+ A + + VAASVGPYGA LADGS Sbjct 65 SYQASFPGFGARGIGRGDAAALMRRSVELARQAAERLEPDRPRWVAASVGPYGATLADGS 124 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YGL+V+ L+ +H PRLEVL AG D+LALET+PD+DEA ALV V + PAWLS Sbjct 125 EYRGRYGLTVSDLVGFHRPRLEVLAGAGPDVLALETVPDLDEAIALVEAVDGIGVPAWLS 184 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 YT+ RTRAGQPL +AF VA +IVAVGVNCC+P +V PA+A A TGKPV+ YPN Sbjct 185 YTVADGRTRAGQPLAEAFEVARDHEDIVAVGVNCCSPAEVAPALAIARQVTGKPVVAYPN 244 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 SGE WD R W G RF G++ A W GA ++GGCCRVRP DIA++ L Sbjct 245 SGEDWDAHCRTWTGASRFPGTA---ASAWAHEGAAVIGGCCRVRPDDIADLAATL 296 >gi|337768639|emb|CCB77352.1| Homocysteine S-methyltransferase 4 [Streptomyces cattleya NRRL 8057] Length=302 Score = 326 bits (836), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 176/294 (60%), Positives = 208/294 (71%), Gaps = 11/294 (3%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ +L +G DLSD LWSARLL DAP I A H AY RAGA++ T+SYQA++E Sbjct 15 VVLDGGLSNQLADQGCDLSDALWSARLLADAPEQIEAAHAAYLRAGARVLITSSYQATYE 74 Query 69 GFAARGIGHDDATVLLRRSVELAQAA---RDEVGVGGLSVAASVGPYGAALADGSEYRGY 125 GFA RG+ A LLRRSV LA+ A RD+V VAASVGPYGA LADGSEYRG Sbjct 75 GFARRGLERRAAGELLRRSVRLARRAAGGRDDV-----WVAASVGPYGAMLADGSEYRGR 129 Query 126 YGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTING 185 YGLSVA L ++H PR+E L +A D+LALET+PD DEAEAL+ V P WLSYT+ G Sbjct 130 YGLSVAELTRFHRPRIETLAEAAPDVLALETVPDADEAEALLRAVEGTGVPVWLSYTVAG 189 Query 186 TRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGW 245 RTRAGQPL DAFA+AAGVP+++AVGVNCC+ +D PA+A A TGKPV+VYPNSGE W Sbjct 190 DRTRAGQPLADAFALAAGVPQVIAVGVNCCSAEDAGPAVALARQVTGKPVVVYPNSGERW 249 Query 246 DGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAP 299 D RAW G F S W AAGAR++GGCCRV P IAE+ AL AP Sbjct 250 DAEARAWRGGATFDPSR---VEGWTAAGARLIGGCCRVGPRRIAELASALRPAP 300 >gi|297203247|ref|ZP_06920644.1| homocysteine methyltransferase [Streptomyces sviceus ATCC 29083] gi|197711333|gb|EDY55367.1| homocysteine methyltransferase [Streptomyces sviceus ATCC 29083] Length=313 Score = 322 bits (826), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 173/291 (60%), Positives = 205/291 (71%), Gaps = 7/291 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGG++ +LE+ GHDLSD LWSARLL + P AIT H AY+ AGA +A T+SYQA+FE Sbjct 25 VVLDGGMSNQLESAGHDLSDELWSARLLAERPEAITEAHLAYYEAGADVAITSSYQATFE 84 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGG----LSVAASVGPYGAALADGSEYRG 124 GFA RGIG + A LL SV LAQ A + G L VAASVGPYGA LADGSEYRG Sbjct 85 GFAKRGIGRERAAELLALSVGLAQEATRQAQAKGVRRPLYVAASVGPYGAMLADGSEYRG 144 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSVA L +H PRLEVL AG D+LALETIPD DEA+AL+ VR L PAWLSY++ Sbjct 145 RYGLSVAELEAFHRPRLEVLAAAGPDVLALETIPDSDEAQALLRAVRGLGVPAWLSYSVA 204 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQPL +AFA+AA V E++AVGVNCC P+DV AI A TGKPV+VYPNSGE Sbjct 205 GDRTRAGQPLEEAFALAADVDEVIAVGVNCCVPEDVDNAIETAARVTGKPVVVYPNSGET 264 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 W+ R W G F+ W A+GAR++GGCCRV P I+ I A+ Sbjct 265 WNAGARRWEGRSSFTSDE---VMGWRASGARLIGGCCRVGPEAISGIAGAV 312 >gi|290956464|ref|YP_003487646.1| transferase [Streptomyces scabiei 87.22] gi|260645990|emb|CBG69081.1| putative transferase [Streptomyces scabiei 87.22] Length=317 Score = 320 bits (819), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 176/287 (62%), Positives = 203/287 (71%), Gaps = 7/287 (2%) Query 13 GGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFEGFAA 72 GG++ +LE+ GHDLSD LWSARLL ++P AIT H AYF AGA +A TASYQA+F+GFA Sbjct 33 GGMSNQLESAGHDLSDELWSARLLAESPKAITEAHLAYFEAGANVAITASYQATFDGFAK 92 Query 73 RGIGHDDATVLLRRSVELAQAARDEVGVGG----LSVAASVGPYGAALADGSEYRGYYGL 128 RGI D A L+ S+ LA A E G G L VAASVGPYGA LADGSEYRG YGL Sbjct 93 RGIDGDRAAELMALSIGLAADAAAEAGTRGEARPLLVAASVGPYGAMLADGSEYRGRYGL 152 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 VA L ++H PRLEVL A D+LALETIPD DEAEAL+ VR L PAWLSYT+ G RT Sbjct 153 GVAELERFHRPRLEVLAAARPDVLALETIPDTDEAEALLRAVRGLDVPAWLSYTVAGDRT 212 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQPL +AFA+AA EIVAVGVNCCA +DV AI AV TGKPV+VYPNSGE WD Sbjct 213 RAGQPLEEAFALAADAEEIVAVGVNCCASEDVDGAIETAVRVTGKPVVVYPNSGETWDAA 272 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 R+W G F + + W AAGAR++GGCCRV P ++ I R L Sbjct 273 ARSWTGRSTF---TTEQVLGWRAAGARLIGGCCRVGPEAVSAIARTL 316 >gi|345009879|ref|YP_004812233.1| homocysteine S-methyltransferase [Streptomyces violaceusniger Tu 4113] gi|344036228|gb|AEM81953.1| homocysteine S-methyltransferase [Streptomyces violaceusniger Tu 4113] Length=329 Score = 316 bits (809), Expect = 3e-84, Method: Compositional matrix adjust. Identities = 175/309 (57%), Positives = 213/309 (69%), Gaps = 29/309 (9%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL+ +LEA+G DLSD LWSARLL D P I A HTAY RAGA++ T+SYQA++E Sbjct 17 LVLDGGLSNQLEAQGCDLSDELWSARLLADDPGQIEAAHTAYARAGARVLITSSYQATYE 76 Query 69 GFAARGIGHDDATVLLRRSVELAQA-----------ARDEVG----VGG----------- 102 GFA RG+GH+ AT LLRRSVELA+ ARD+ VGG Sbjct 77 GFAHRGVGHEQATALLRRSVELARTGAERAATERATARDQAAGDRAVGGDRAADDRAAEP 136 Query 103 LSVAASVGPYGAALADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDE 162 + VAASVGPYGA LADGSEYRG YGLSVA L+++H PR+E L AG D+LALET+PD DE Sbjct 137 VWVAASVGPYGAMLADGSEYRGRYGLSVAELVRFHRPRIEALAAAGPDVLALETVPDADE 196 Query 163 AEALVNLVRRLATPAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLP 222 A AL++ V P WLSY+I G TRAGQPL +AFA+AAGV +++AVGVNCC P D Sbjct 197 AAALLSAVEGCGVPVWLSYSIAGETTRAGQPLREAFALAAGVDQVIAVGVNCCEPGDADR 256 Query 223 AIAFAVAHTGKPVIVYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCR 282 A+ A TGKPV+VYPNSGE WD R+W G R + G++ + W AGAR++GGCCR Sbjct 257 AVEIAADITGKPVVVYPNSGEEWDATARSWRG--RATFDPGRV-KAWRDAGARLIGGCCR 313 Query 283 VRPIDIAEI 291 V P IAE+ Sbjct 314 VGPERIAEL 322 >gi|345002614|ref|YP_004805468.1| homocysteine S-methyltransferase [Streptomyces sp. SirexAA-E] gi|344318240|gb|AEN12928.1| homocysteine S-methyltransferase [Streptomyces sp. SirexAA-E] Length=308 Score = 314 bits (804), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 171/298 (58%), Positives = 203/298 (69%), Gaps = 4/298 (1%) Query 3 LVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS 62 L + L+ DGGL+ +L A+G DLSD LWSARLL DAP I A H AY RAGAQ+ TAS Sbjct 15 LAAGETLVLDGGLSNQLRAQGCDLSDALWSARLLADAPQQIEAAHAAYVRAGAQVLITAS 74 Query 63 YQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEY 122 YQA+F+GF RGIG + A L+ SVELA+ A G + VAASVGPYGA LADGSEY Sbjct 75 YQATFDGFERRGIGREGAAELMAGSVELARRAAGRSGRE-VWVAASVGPYGAMLADGSEY 133 Query 123 RGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYT 182 RG YGL+V L ++H PR+E L +A D LALET+PD DEAEA++ VR P WLSYT Sbjct 134 RGRYGLTVRELERFHRPRIEALAEAAPDALALETVPDTDEAEAMLGAVRGCGLPVWLSYT 193 Query 183 INGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSG 242 + G RTRAGQPL DAFA+AAG ++VAVGVNCC P D A+ A A TGKPV+VYPNSG Sbjct 194 VAGERTRAGQPLADAFALAAGEDQVVAVGVNCCDPADADRAVEVAAAVTGKPVVVYPNSG 253 Query 243 EGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP 300 E WD R W G F + A W AGAR+VGGCCRV P I+ + AL ++ P Sbjct 254 EIWDAAARGWAGQGTFDAAR---AGGWRRAGARLVGGCCRVGPSGISGLAAALASSGP 308 >gi|302557562|ref|ZP_07309904.1| homocysteine S-methyltransferase [Streptomyces griseoflavus Tu4000] gi|302475180|gb|EFL38273.1| homocysteine S-methyltransferase [Streptomyces griseoflavus Tu4000] Length=312 Score = 313 bits (803), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 178/294 (61%), Positives = 211/294 (72%), Gaps = 4/294 (1%) Query 3 LVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS 62 L VL+ DGG++ +L A GHDLSD LWSARLL + P A+TA H AYF AGA +A TAS Sbjct 19 LADGRVLVLDGGMSNQLAAAGHDLSDELWSARLLAEDPEAVTAAHLAYFEAGADVAITAS 78 Query 63 YQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGG-LSVAASVGPYGAALADGSE 121 YQA+FEGFA RGIG ++A LL SVE A+ A V L VAASVGPYGA LADGSE Sbjct 79 YQATFEGFARRGIGREEAGRLLALSVECARTAARRARVSRPLWVAASVGPYGAMLADGSE 138 Query 122 YRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSY 181 YRG YGL+VA L ++H PR+EVL AG D+LALETIPD DEAEAL+ +R L PAWLSY Sbjct 139 YRGRYGLNVAELERFHRPRMEVLAAAGPDVLALETIPDADEAEALLRALRGLGVPAWLSY 198 Query 182 TINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNS 241 +++G RTRAGQPL +A A+AA E++AVGVNCC PDD AIA A TGKPV+VYPNS Sbjct 199 SVSGDRTRAGQPLEEALALAARADEVIAVGVNCCTPDDADHAIALAARVTGKPVVVYPNS 258 Query 242 GEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 GE WD RAW G F S+GQ+ + W +GAR++GGCCRV P IA + L Sbjct 259 GETWDAGARAWTGRATF--SAGQV-KGWRESGARLIGGCCRVGPGTIASVASVL 309 >gi|32141288|ref|NP_733689.1| homocysteine methyltransferase [Streptomyces coelicolor A3(2)] gi|24413901|emb|CAD55372.1| putative transferase [Streptomyces coelicolor A3(2)] Length=304 Score = 313 bits (802), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 174/291 (60%), Positives = 202/291 (70%), Gaps = 7/291 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL+ +LEA GHDL D LWSARLL + P AIT H AYF AGA++A T+SYQA+FE Sbjct 14 LVLDGGLSNQLEAAGHDLGDALWSARLLAEDPEAITRAHLAYFEAGAEVAITSSYQATFE 73 Query 69 GFAARGIGHDDATVLLRRSV----ELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRG 124 GFA RGIG + A LL SV E A+ AR L VAAS GPYGA LADGSEYRG Sbjct 74 GFARRGIGRERAAELLALSVASAREAARRARTARPERALWVAASAGPYGAMLADGSEYRG 133 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGL AL ++H PRLEVL A D+LALET+PD DEA AL+ VR L PAWLSYT+ Sbjct 134 RYGLGRGALERFHRPRLEVLAAARPDVLALETVPDTDEAAALLRAVRGLDVPAWLSYTVA 193 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQPL +AFA+AA V E++AVGVNCCAP+DV A+ A TGKPV+ YPNSGE Sbjct 194 GDRTRAGQPLDEAFALAADVDEVIAVGVNCCAPEDVSGAVETAARVTGKPVVAYPNSGET 253 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 WD + R W G S + + R+W GAR+VGGCCRV P I I RAL Sbjct 254 WDAKSRGWRGR---SSYTAERVRDWRERGARLVGGCCRVGPETITSIARAL 301 >gi|320007976|gb|ADW02826.1| homocysteine S-methyltransferase [Streptomyces flavogriseus ATCC 33331] Length=311 Score = 313 bits (801), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 169/296 (58%), Positives = 207/296 (70%), Gaps = 4/296 (1%) Query 2 ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTA 61 + +++ ++ DGGL+ +LEA+G DLSD LWSA LL D P I A H AY RAGAQ+ TA Sbjct 17 QALAEGTVLLDGGLSNQLEAQGCDLSDALWSAGLLSDEPRQIEAAHRAYARAGAQVLITA 76 Query 62 SYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSE 121 SYQA+FEGFA RGIG A L+ SVELA+ A + G VAASVGPYGA LADGSE Sbjct 77 SYQATFEGFARRGIGRARAAELMAGSVELARRAGADTGRESW-VAASVGPYGAMLADGSE 135 Query 122 YRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSY 181 YRG YG++V L+++H PR+E L AG D+LALET+PD DEAEAL+ V+ L P WLSY Sbjct 136 YRGRYGMTVRELVRFHRPRVETLAAAGPDVLALETVPDADEAEALLRAVQDLDVPVWLSY 195 Query 182 TINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNS 241 ++ G RTRAGQPL +AF +AAG+ ++VAVGVNCC P D A+ A A TGKPV+VYPNS Sbjct 196 SVAGDRTRAGQPLAEAFGLAAGIDQVVAVGVNCCDPADADRAVEVAAAATGKPVVVYPNS 255 Query 242 GEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTT 297 GE WD R W G F G++ R W AGAR+VGGCCRV P +I +G L T Sbjct 256 GEEWDADGRDWTGRSTF--EPGRV-RHWRNAGARLVGGCCRVGPSNIEALGARLRT 308 >gi|289768223|ref|ZP_06527601.1| homocysteine methyltransferase [Streptomyces lividans TK24] gi|289698422|gb|EFD65851.1| homocysteine methyltransferase [Streptomyces lividans TK24] Length=304 Score = 311 bits (798), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 174/291 (60%), Positives = 201/291 (70%), Gaps = 7/291 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL+ +LEA GHDL D LWSARLL + P AIT H AYF AGA++A T+SYQA+FE Sbjct 14 LVLDGGLSNQLEAAGHDLGDALWSARLLAEDPEAITRAHLAYFEAGAEVAITSSYQATFE 73 Query 69 GFAARGIGHDDATVLLRRSV----ELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRG 124 GFA RGIG + A LL SV E A+ AR L VAAS GPYGA LADGSEYRG Sbjct 74 GFARRGIGRERAAELLALSVASAREAARRARTARPERALWVAASAGPYGAMLADGSEYRG 133 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGL AL ++H PRLEVL A D+LALET+PD DEA AL+ VR L PAWLSYT+ Sbjct 134 RYGLGRGALERFHRPRLEVLAAARPDVLALETVPDTDEAAALLRAVRGLDVPAWLSYTVA 193 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQPL +AFA+AA E++AVGVNCCAP+DV A+ A TGKPV+ YPNSGE Sbjct 194 GDRTRAGQPLDEAFALAADADEVIAVGVNCCAPEDVSGAVETAARVTGKPVVAYPNSGET 253 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 WD R R W G S + + R+W GAR+VGGCCRV P I I RAL Sbjct 254 WDARSRGWRGR---SSYTAERVRDWWERGARLVGGCCRVGPETITSIARAL 301 >gi|297191400|ref|ZP_06908798.1| homocysteine methyltransferase [Streptomyces pristinaespiralis ATCC 25486] gi|197722332|gb|EDY66240.1| homocysteine methyltransferase [Streptomyces pristinaespiralis ATCC 25486] Length=300 Score = 310 bits (795), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 167/294 (57%), Positives = 202/294 (69%), Gaps = 4/294 (1%) Query 4 VSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASY 63 + + +++ DGGL+ +L+A+G DLS LWSARLL D P I A HTAY RAGAQ+ T+SY Sbjct 11 LEEGIVVLDGGLSNQLQAQGCDLSGGLWSARLLADDPEQIRAAHTAYVRAGAQVLITSSY 70 Query 64 QASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYR 123 QA+FEGFA RG G A LL RSV LA++A D G + VAASVGPYGA LADGSEYR Sbjct 71 QATFEGFARRGTGRAQAAGLLGRSVGLARSAADAAG-HEVWVAASVGPYGAMLADGSEYR 129 Query 124 GYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTI 183 G YGL V L ++H PR+E L AG D+LALET+PD DEA+AL+ P WLSYT+ Sbjct 130 GRYGLGVRELERFHRPRIEALAAAGPDVLALETVPDTDEAQALLEAAEGCGVPLWLSYTV 189 Query 184 NGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGE 243 RTRAGQPL +AFA+AAG E++AVGVNCC P + A+A A TGKP +VYPNSGE Sbjct 190 AEGRTRAGQPLAEAFALAAGRDEVIAVGVNCCDPREATAAVALATEITGKPAVVYPNSGE 249 Query 244 GWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTT 297 WD +W G SG REW AAGAR+ GGCCRV P +IAE+ R L + Sbjct 250 RWDAASSSWQGG---SGYDPVRVREWRAAGARLAGGCCRVGPREIAELARLLHS 300 >gi|291454931|ref|ZP_06594321.1| homocysteine methyltransferase [Streptomyces albus J1074] gi|291357880|gb|EFE84782.1| homocysteine methyltransferase [Streptomyces albus J1074] Length=306 Score = 308 bits (788), Expect = 8e-82, Method: Compositional matrix adjust. Identities = 180/297 (61%), Positives = 211/297 (72%), Gaps = 10/297 (3%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 V + + ++ DGGL+ +L ARG+DLSD LWSARLL DAP + A H AY+ AGA++A T Sbjct 8 VAALGERAVVVDGGLSEQLAARGNDLSDALWSARLLADAPEEVVAAHRAYYAAGAEVAIT 67 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEV----GVGG-LSVAASVGPYGAA 115 ASYQA+FEGFA RG+G A LL SV LA+ A DE GV G L VAAS GPYGA Sbjct 68 ASYQATFEGFARRGVGRVAAARLLGDSVGLARRAADEAREADGVTGPLWVAASAGPYGAM 127 Query 116 LADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLAT 175 LADGSEYRG YGLSVA L ++H PRLEVL AG D+LALET+PD DEA AL+ VR L Sbjct 128 LADGSEYRGRYGLSVAELERFHRPRLEVLAAAGPDVLALETVPDADEARALLRAVRGLGV 187 Query 176 PAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPV 235 PAWLSY++ G RTRAG L DAFA+AA PE+VAVGVNCC P +V PA+ A TGKPV Sbjct 188 PAWLSYSVAGGRTRAGDRLADAFALAADAPEVVAVGVNCCDPREVEPAVRLAAHVTGKPV 247 Query 236 IVYPNSGEGWDGRRRAWVGPRR-FSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 + YPNSGE WD RAW GP + +G LA EWVAAGAR+VGGCCRV + E+ Sbjct 248 VAYPNSGERWDAAARAWRGPAQPLAG----LAGEWVAAGARLVGGCCRVGAQAVREV 300 >gi|291436474|ref|ZP_06575864.1| homocysteine methyltransferase [Streptomyces ghanaensis ATCC 14672] gi|291339369|gb|EFE66325.1| homocysteine methyltransferase [Streptomyces ghanaensis ATCC 14672] Length=304 Score = 306 bits (784), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 175/293 (60%), Positives = 210/293 (72%), Gaps = 4/293 (1%) Query 4 VSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASY 63 ++D ++ DGG++ +L + GHDLSD LWSARLL + P A+TA H AYF AGA +A TASY Sbjct 12 LADGTVVLDGGMSNQLASAGHDLSDELWSARLLAEDPEAVTAAHLAYFEAGADVAITASY 71 Query 64 QASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGG-LSVAASVGPYGAALADGSEY 122 QA+FEGFA RGIG A LL SVE A+ A L VAASVGPYGA LADGSEY Sbjct 72 QATFEGFARRGIGRGRAAELLALSVECAREAARRARAARPLWVAASVGPYGAMLADGSEY 131 Query 123 RGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYT 182 RG YGLSVA L ++H PR EVL A D+LALETIPD DEAEAL+ ++R L TPAWLSY+ Sbjct 132 RGRYGLSVAELERFHRPRTEVLAAARPDVLALETIPDTDEAEALLRVLRGLGTPAWLSYS 191 Query 183 INGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSG 242 G RTRAGQPL DAFA+AA E++AVGVNCC P+D A+A A TGKPV+VYPNSG Sbjct 192 AAGDRTRAGQPLEDAFALAADADEVIAVGVNCCTPEDADRAVALAARVTGKPVVVYPNSG 251 Query 243 EGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 E WD RAW G F ++G++A W +GAR+VGGCCRV P I+ I +A+ Sbjct 252 ETWDTGARAWTGRPTF--TAGRVA-GWRESGARLVGGCCRVGPETISAIAKAV 301 >gi|239991425|ref|ZP_04712089.1| homocysteine methyltransferase [Streptomyces roseosporus NRRL 11379] Length=325 Score = 305 bits (781), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 166/287 (58%), Positives = 195/287 (68%), Gaps = 7/287 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ +LEA+G DLSD LWSARLL DAP I A H AY RAGA++ TASYQA+FE Sbjct 18 VLLDGGLSNQLEAQGCDLSDALWSARLLADAPEQIEAAHLAYLRAGARVLITASYQATFE 77 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS----VAASVGPYGAALADGSEYRG 124 GF G+ L RSVELA++A D G VAASVGPYGA LADGSEYRG Sbjct 78 GFGRYGLDRSGTEALFARSVELARSAADAARRAGPGRKTWVAASVGPYGAMLADGSEYRG 137 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSV L ++H PR+ L AG D+LALET+PD+DEAEALV + P WLSY++ Sbjct 138 RYGLSVGELERFHRPRVAALAAAGPDVLALETVPDLDEAEALVRVAEETGLPYWLSYSVA 197 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQPL +AFAVAAG ++AVGVNCC PD+ A+ AVA TG+P +VYPNSGEG Sbjct 198 GGRTRAGQPLEEAFAVAAGRESVLAVGVNCCDPDEAQAAVELAVAVTGRPAVVYPNSGEG 257 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 WD R W G F R W AGAR+VGGCCRV P IAE+ Sbjct 258 WDAGARGWTGRSTFDPDR---VRAWTRAGARLVGGCCRVGPDLIAEL 301 >gi|291448422|ref|ZP_06587812.1| homocysteine methyltransferase [Streptomyces roseosporus NRRL 15998] gi|291351369|gb|EFE78273.1| homocysteine methyltransferase [Streptomyces roseosporus NRRL 15998] Length=323 Score = 305 bits (781), Expect = 6e-81, Method: Compositional matrix adjust. Identities = 166/287 (58%), Positives = 195/287 (68%), Gaps = 7/287 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ +LEA+G DLSD LWSARLL DAP I A H AY RAGA++ TASYQA+FE Sbjct 16 VLLDGGLSNQLEAQGCDLSDALWSARLLADAPEQIEAAHLAYLRAGARVLITASYQATFE 75 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS----VAASVGPYGAALADGSEYRG 124 GF G+ L RSVELA++A D G VAASVGPYGA LADGSEYRG Sbjct 76 GFGRYGLDRSGTEALFARSVELARSAADAARRAGPGRKTWVAASVGPYGAMLADGSEYRG 135 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSV L ++H PR+ L AG D+LALET+PD+DEAEALV + P WLSY++ Sbjct 136 RYGLSVGELERFHRPRVAALAAAGPDVLALETVPDLDEAEALVRVAEETGLPYWLSYSVA 195 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQPL +AFAVAAG ++AVGVNCC PD+ A+ AVA TG+P +VYPNSGEG Sbjct 196 GGRTRAGQPLEEAFAVAAGRESVLAVGVNCCDPDEAQAAVELAVAVTGRPAVVYPNSGEG 255 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 WD R W G F R W AGAR+VGGCCRV P IAE+ Sbjct 256 WDAGARGWTGRSTFDPDR---VRAWTRAGARLVGGCCRVGPDLIAEL 299 >gi|302555024|ref|ZP_07307366.1| homocysteine methyltransferase [Streptomyces viridochromogenes DSM 40736] gi|302472642|gb|EFL35735.1| homocysteine methyltransferase [Streptomyces viridochromogenes DSM 40736] Length=303 Score = 303 bits (775), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 167/298 (57%), Positives = 205/298 (69%), Gaps = 4/298 (1%) Query 2 ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTA 61 E ++ ++ DGG++ +LE+ GHDLSD LWSARLL + P A+T H AYFRAGA +A TA Sbjct 9 EALAAGTVVLDGGMSNQLESAGHDLSDELWSARLLAEQPEAVTEAHLAYFRAGADVAITA 68 Query 62 SYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVG-GLSVAASVGPYGAALADGS 120 SYQA+FEGF RGI A L+ SVE A+ A + GV L VAASVGPYGA LADGS Sbjct 69 SYQATFEGFGKRGINPGRAAELMALSVESAREAAGQAGVSRPLWVAASVGPYGAMLADGS 128 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YGL+V L ++H PR+E L A D+LALET+PD +EA AL+ VR L PAWL+ Sbjct 129 EYRGRYGLTVDELERFHRPRMEALAAARPDVLALETVPDAEEAAALLRAVRGLGVPAWLT 188 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 Y+I G TRAGQPL +AFA+AA V E++AVGVNCCAP+DV A A A TGKPV++YPN Sbjct 189 YSIAGGSTRAGQPLEEAFALAADVDEVIAVGVNCCAPEDVDGAAATAARVTGKPVVIYPN 248 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTA 298 SGE W+ RAW G F+ + W AGAR++GGCCRV P I+ I L A Sbjct 249 SGETWNAEARAWTGRSTFTPDQ---VKGWQQAGARLIGGCCRVGPEAISGIAGTLGAA 303 >gi|328885829|emb|CCA59068.1| Homocysteine S-methyltransferase [Streptomyces venezuelae ATCC 10712] Length=307 Score = 303 bits (775), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 174/299 (59%), Positives = 204/299 (69%), Gaps = 12/299 (4%) Query 2 ELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTA 61 E + D L+ DGGL+ +LEA+G DLSD LWSARLL D P I A H AY RAGA++ T+ Sbjct 9 EALGDGALVLDGGLSNQLEAQGCDLSDALWSARLLADGPEQIEAAHAAYVRAGARVLITS 68 Query 62 SYQASFEGFAARGIGHDDATVLLRRSVELAQAA----RDEVGVGGLSVAASVGPYGAALA 117 SYQA+ EGFA RG+G A LL RSVELA+AA R+EV VAASVGPYGA LA Sbjct 69 SYQATVEGFARRGVGRAAAERLLARSVELARAAARGVREEV-----WVAASVGPYGAMLA 123 Query 118 DGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPA 177 DGSEYRG YGLSV L +H PR+EVL A D+LALET+PD +EAEAL+ P Sbjct 124 DGSEYRGRYGLSVRELEAFHRPRIEVLAAAEPDVLALETVPDAEEAEALLRAAEGCGVPV 183 Query 178 WLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIV 237 WLSYT+ G RTRAGQ L +AFAVAAG ++VAVGVNCC P + A+A A A TG+P +V Sbjct 184 WLSYTVEGGRTRAGQDLAEAFAVAAGNDQVVAVGVNCCDPAEAGAAVALAAAVTGRPGVV 243 Query 238 YPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 YPNSGE WD R R W G F + LA W A+GAR+VGGCCRV P IA + LT Sbjct 244 YPNSGERWDARARGWRGAVAFDPA---LATGWAASGARLVGGCCRVGPETIAALATTLT 299 >gi|302541970|ref|ZP_07294312.1| homocysteine S-methyltransferase [Streptomyces hygroscopicus ATCC 53653] gi|302459588|gb|EFL22681.1| homocysteine S-methyltransferase [Streptomyces himastatinicus ATCC 53653] Length=306 Score = 301 bits (772), Expect = 6e-80, Method: Compositional matrix adjust. Identities = 163/285 (58%), Positives = 196/285 (69%), Gaps = 5/285 (1%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL+ +LEA+G DLSD LWSARLL D P I A H AY RAGA++ T+SYQA++E Sbjct 18 LVLDGGLSNQLEAQGCDLSDELWSARLLADDPGQIEAAHAAYVRAGARVLITSSYQATYE 77 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAA--SVGPYGAALADGSEYRGYY 126 GFA RG+ +DAT LL RSVELA+ A V SVGPYGA LADGSEYRG Y Sbjct 78 GFAHRGVAREDATALLGRSVELARGAARGAAAPAAPVWVAASVGPYGAMLADGSEYRGRY 137 Query 127 GLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGT 186 GLSVA L ++H PR+E LV AG D+LALET+PD DEA A++ V P WLSY+I G Sbjct 138 GLSVAELERFHRPRIEALVAAGPDVLALETVPDADEAAAMLRAVEGSGVPVWLSYSIAGE 197 Query 187 RTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWD 246 TRAGQPL +AFAVAAG +++AVG+NCC P D A+ A TGKPV+VYPNSGE WD Sbjct 198 ATRAGQPLREAFAVAAGNEQVIAVGINCCEPGDADRAVEIAAETTGKPVVVYPNSGEEWD 257 Query 247 GRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 R+W G F + + W AGAR++GGCCRV P IAE+ Sbjct 258 ATARSWRGRSTFDPAR---VKGWRDAGARLIGGCCRVGPDRIAEL 299 >gi|29828653|ref|NP_823287.1| homocysteine methyltransferase [Streptomyces avermitilis MA-4680] gi|29605757|dbj|BAC69822.1| putative homocysteine S-methyltransferase [Streptomyces avermitilis MA-4680] Length=313 Score = 299 bits (766), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 171/291 (59%), Positives = 202/291 (70%), Gaps = 7/291 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ +LE+ GHDLSD LWSARLL + P AIT H AYF AGA +A T+SYQA+FE Sbjct 16 VVLDGGLSNQLESAGHDLSDELWSARLLAERPEAITEAHLAYFEAGADVAITSSYQATFE 75 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS----VAASVGPYGAALADGSEYRG 124 GFA RGI + A LL SV LA+ A G++ VAASVGPYGA LADGSEYRG Sbjct 76 GFAKRGIPEERAAELLGLSVGLAREAAVRARADGVTRPLWVAASVGPYGAMLADGSEYRG 135 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGL+VA L +H PRLEVL AG D+LALET+PD DEAEAL+ VR L PAWLSY+++ Sbjct 136 RYGLTVAELEAFHRPRLEVLAAAGPDVLALETVPDADEAEALLRAVRGLGVPAWLSYSVS 195 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 G RTRAGQ L +AFA AA E++AVGVNCCAP+DV A+ A TGKPV+VYPNSGE Sbjct 196 GDRTRAGQSLEEAFAPAAEADEVIAVGVNCCAPEDVDGAVETAARVTGKPVVVYPNSGET 255 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 WD RAW G F + + W AGAR++GGCCRV P I I L Sbjct 256 WDAGARAWSGRSTF---TAEQVTGWRRAGARLIGGCCRVGPAAITSIAGTL 303 >gi|297156629|gb|ADI06341.1| homocysteine methyltransferase [Streptomyces bingchenggensis BCW-1] Length=308 Score = 293 bits (751), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 166/288 (58%), Positives = 200/288 (70%), Gaps = 10/288 (3%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL+ +LEA+G DLSD LWSARLL D P I H AY RAGA++ T+SYQA++E Sbjct 17 LVLDGGLSNQLEAQGCDLSDELWSARLLADDPRQIEEAHAAYARAGARVLITSSYQATYE 76 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGG-----LSVAASVGPYGAALADGSEYR 123 GFA RG+ +AT LL RSVELA+ A + G GG + VAASVGPYGA LADGSEYR Sbjct 77 GFARRGVLEKEATALLERSVELARRAAE--GAGGTVDRPVWVAASVGPYGAMLADGSEYR 134 Query 124 GYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTI 183 G YGLSV L ++H PR+E L AG D+LALET+PD DEAEAL+ V P WLSY+I Sbjct 135 GRYGLSVGELERFHRPRIEALAAAGPDVLALETVPDADEAEALLRAVEGCGIPVWLSYSI 194 Query 184 NGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGE 243 G TRAGQPL +AFA+AAG +++AVGVNCC P D A+ A TGKPV+VYPNSGE Sbjct 195 AGEHTRAGQPLREAFALAAGNDQVLAVGVNCCEPGDADRAVEVAATTTGKPVVVYPNSGE 254 Query 244 GWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 WD + R W G F + + W AGAR++GGCCRV P IAE+ Sbjct 255 EWDAKARGWRGRATFDPAR---VKAWRDAGARLIGGCCRVGPDRIAEL 299 >gi|148274014|ref|YP_001223575.1| homocysteine methyltransferase [Clavibacter michiganensis subsp. michiganensis NCPPB 382] gi|147831944|emb|CAN02915.1| putative homocysteine S-methyltransferase [Clavibacter michiganensis subsp. michiganensis NCPPB 382] Length=301 Score = 293 bits (750), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 162/299 (55%), Positives = 195/299 (66%), Gaps = 12/299 (4%) Query 4 VSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASY 63 + D L+ DGGL T LEARGHDLSDPLWSAR+L D P A+ A H +FRAGA +A TASY Sbjct 7 LPDRPLVLDGGLGTLLEARGHDLSDPLWSARVLADEPDAVRAAHAEFFRAGADVAITASY 66 Query 64 QASFEGFAARGIGHDDATVLLRRSVELAQAARDEV------GVG-GLSVAASVGPYGAAL 116 Q FE FAARG+G D LLR SV LA ARDEV G G +AASVGPYGA L Sbjct 67 QVGFEAFAARGLGTADTEALLRASVRLAAEARDEVAREDAAGAGRDRWIAASVGPYGATL 126 Query 117 ADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATP 176 DGSEY G GL+ L +WH PR VL DAGAD+LA ETIP +DE ALV+L R Sbjct 127 GDGSEYAGSSGLTRDELRRWHAPRFAVLADAGADLLACETIPSLDEGRALVDLARGSGAS 186 Query 177 AWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVI 236 AWL++T+ G R R+G+P+ + FA+A E+VAVG+NC P++V AIA A + T +PV+ Sbjct 187 AWLAFTVEGGRLRSGEPMAEGFALADEADEVVAVGINCAHPEEVPAAIAAARSVTDRPVV 246 Query 237 VYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 VYPNSGE WD RAW G W+ AGA +VGGCC+V P +IA + AL Sbjct 247 VYPNSGERWDAVARAWGGDPALPAVDA-----WIRAGASLVGGCCQVGPDEIARMRDAL 300 >gi|258654689|ref|YP_003203845.1| homocysteine methyltransferase [Nakamurella multipartita DSM 44233] gi|258557914|gb|ACV80856.1| homocysteine S-methyltransferase [Nakamurella multipartita DSM 44233] Length=320 Score = 290 bits (742), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 166/296 (57%), Positives = 199/296 (68%), Gaps = 10/296 (3%) Query 6 DSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQA 65 D L+ DGGLAT LEA GHDL+ LWSA+LLV P AITA H YFRAGAQ+A TASYQA Sbjct 13 DRPLVLDGGLATLLEAHGHDLTSALWSAQLLVQNPGAITAAHREYFRAGAQVAITASYQA 72 Query 66 SFEGFAARGIGHDDATVLLRRSVELAQ-AARDEV------GVGGLSVAASVGPYGAALAD 118 S G AA G+G +A LRRSV+LA+ AA D V G G VA SVGPYGAALAD Sbjct 73 SLPGLAAIGLGRVEAEQALRRSVDLARTAAADGVNEATAPGSGPRWVATSVGPYGAALAD 132 Query 119 GSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAW 178 GSEYRG YGL+V L WH PRLE+L DAG D+LA+ETIP E EAL+ ++ L PAW Sbjct 133 GSEYRGDYGLTVRQLRDWHRPRLEILADAGGDVLAIETIPCAAEVEALLTEIQALDAPAW 192 Query 179 LSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVY 238 LS T RTRAG+ + + FA+AAGV +++AVGVNC + +A A ++GKP +VY Sbjct 193 LSLTCQDGRTRAGERVDEVFAMAAGVDQVIAVGVNCVESAEAADLVAAAAENSGKPAVVY 252 Query 239 PNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRA 294 PNSGE WD + RAW G F + WVA+GAR+VGGCCRV P I + R+ Sbjct 253 PNSGEDWDAQARAWAGRATFGPEHAAV---WVASGARLVGGCCRVGPQAIRRLARS 305 >gi|329940276|ref|ZP_08289558.1| homocysteine methyltransferase [Streptomyces griseoaurantiacus M045] gi|329301102|gb|EGG44998.1| homocysteine methyltransferase [Streptomyces griseoaurantiacus M045] Length=308 Score = 290 bits (741), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 168/299 (57%), Positives = 196/299 (66%), Gaps = 7/299 (2%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 E ++ L+ DGGL+ +LEA GHDL D LWSARLL +AP A+ H AYF AGA +A T Sbjct 10 TEALAAGTLVLDGGLSNQLEAAGHDLGDALWSARLLAEAPEAVVEAHLAYFEAGANVAIT 69 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGG----LSVAASVGPYGAAL 116 ASYQA+FEGFA G+ LL SVE A+ A G L AAS GPYGA L Sbjct 70 ASYQATFEGFARYGLTRARTAELLAYSVESAREAARRARERGVARPLWTAASAGPYGAML 129 Query 117 ADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATP 176 ADGSEYRG YGLSV L +H PRLE L A D+LALET+PD +EA AL+ VR L P Sbjct 130 ADGSEYRGRYGLSVDELADFHRPRLEALAAARPDVLALETVPDTEEARALLRAVRGLGVP 189 Query 177 AWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVI 236 AWLSYT+ G+RTRAGQPL +AFA+AA EIVAVGVNCCAP DV PA+A A TGKPV+ Sbjct 190 AWLSYTVAGSRTRAGQPLEEAFALAAEAEEIVAVGVNCCAPKDVEPAVALAAQVTGKPVV 249 Query 237 VYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 YPNSGE W W GP F + + R W AGAR++GGCCRV P + + AL Sbjct 250 AYPNSGETWHADTAGWTGPVTF---TPEAVRNWRRAGARLIGGCCRVGPTGVRGVAEAL 305 >gi|170783269|ref|YP_001711603.1| homocysteine methyltransferase [Clavibacter michiganensis subsp. sepedonicus] gi|169157839|emb|CAQ03045.1| homocysteine s-methyltransferase [Clavibacter michiganensis subsp. sepedonicus] Length=301 Score = 289 bits (739), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 161/294 (55%), Positives = 190/294 (65%), Gaps = 12/294 (4%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL T LEARGHDLSDPLWSAR+L D P A+ A H YFRAGA +A TASYQ FE Sbjct 12 LVLDGGLGTLLEARGHDLSDPLWSARVLADEPDAVRAAHAEYFRAGADVAITASYQVGFE 71 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEV------GVG-GLSVAASVGPYGAALADGSE 121 FAARG+ + LLR SV LA ARDEV G G +AASVGPYGA L DGSE Sbjct 72 AFAARGLSAAETEELLRASVRLAAEARDEVAQDDAPGAGRDRWIAASVGPYGATLGDGSE 131 Query 122 YRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSY 181 Y GL+ A L +WH PR VL D+GAD+LA ET+P +DE ALV+L R AWL++ Sbjct 132 YAASSGLTRAELRRWHAPRFAVLADSGADLLACETVPSLDEGRALVDLARGSGASAWLAF 191 Query 182 TINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNS 241 T+ G R R+G+P+ + F +A G EIVAVG+NC P++V AIA A T +PV VYPNS Sbjct 192 TVQGGRLRSGEPMAEGFRLANGADEIVAVGINCAHPEEVPAAIAAARGVTDRPVAVYPNS 251 Query 242 GEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRAL 295 GE WD RAW G W+AAGA IVGGCCRV P +I + AL Sbjct 252 GERWDAVARAWGGDPALPSVDA-----WIAAGASIVGGCCRVGPDEIRRMRDAL 300 >gi|311894980|dbj|BAJ27388.1| putative homocysteine S-methyltransferase [Kitasatospora setae KM-6054] Length=312 Score = 286 bits (733), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 161/288 (56%), Positives = 194/288 (68%), Gaps = 8/288 (2%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 V ++D ++ DGGL+ L +G DLSD LWSARLL+D P + A H AYF AGAQ+ATT Sbjct 14 VAAMADGPVLLDGGLSNRLAEQGCDLSDGLWSARLLLDEPGQLLAAHRAYFAAGAQVATT 73 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEV----GVGGLS-VAASVGPYGAA 115 ASYQAS GFAARG+ LL SVE+A+ A +EV G G VAASVGPYGA Sbjct 74 ASYQASRAGFAARGVDAAKTDRLLALSVEVARLAAEEVSAELGDGRPRWVAASVGPYGAV 133 Query 116 LADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLAT 175 LADGSEYRG+YGLS A L ++H PRLE L AG D+LA+ET+PD+ EA L + VR L Sbjct 134 LADGSEYRGHYGLSAAELAEFHRPRLEALAAAGPDVLAVETVPDLLEAAVLADCVRGLGV 193 Query 176 PAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPV 235 P W S+ TR G+PL++ FA+ A VPE +AVGVNCCAP +V A+A A TG P Sbjct 194 PVWFSFGAADGLTRGGEPLSEVFALVAEVPETIAVGVNCCAPREVDAAVALAAEVTGLPA 253 Query 236 IVYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRV 283 + YPNSGEGWD R W G F + LA +WVAAGAR+VGGCCRV Sbjct 254 VAYPNSGEGWDAAARDWTGEAAFDPA---LAADWVAAGARLVGGCCRV 298 >gi|182435369|ref|YP_001823088.1| homocysteine methyltransferase [Streptomyces griseus subsp. griseus NBRC 13350] gi|178463885|dbj|BAG18405.1| putative homocysteine S-methyltransferase [Streptomyces griseus subsp. griseus NBRC 13350] Length=307 Score = 279 bits (714), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 164/287 (58%), Positives = 193/287 (68%), Gaps = 7/287 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ +LEA+G DLSD LWSARLL DAP I A H AY RAGA++ TASYQA+FE Sbjct 18 VLLDGGLSNQLEAQGCDLSDALWSARLLADAPEQIEAAHLAYLRAGARVLITASYQATFE 77 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS----VAASVGPYGAALADGSEYRG 124 GF G+ LL RSVELA+ A + VAASVGPYGA LADGSEYRG Sbjct 78 GFGRYGLDRAATGALLARSVELARRAAEAARRADPGRETWVAASVGPYGAMLADGSEYRG 137 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSV L ++H PR+ L AG D LALET+PD+DEAEALV + P WLSY++ Sbjct 138 RYGLSVRELERFHRPRVAALAAAGPDALALETVPDLDEAEALVRVAEETGLPYWLSYSVA 197 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 RTRAGQPL +AFAVAAG ++AVGVNCC P + A+ AVA TG+P +VYPNSGEG Sbjct 198 DGRTRAGQPLQEAFAVAAGRDSVLAVGVNCCDPQEARGAVEQAVAVTGRPAVVYPNSGEG 257 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 WD R W G F GQ+ R W AGAR+VGGCCRV P I E+ Sbjct 258 WDAGARGWTGHGTF--DPGQV-RAWTRAGARLVGGCCRVGPDLITEL 301 >gi|254390558|ref|ZP_05005773.1| homocysteine methyltransferase [Streptomyces clavuligerus ATCC 27064] gi|294815640|ref|ZP_06774283.1| Homocysteine methyltransferase [Streptomyces clavuligerus ATCC 27064] gi|326443989|ref|ZP_08218723.1| homocysteine methyltransferase [Streptomyces clavuligerus ATCC 27064] gi|197704260|gb|EDY50072.1| homocysteine methyltransferase [Streptomyces clavuligerus ATCC 27064] gi|294328239|gb|EFG09882.1| Homocysteine methyltransferase [Streptomyces clavuligerus ATCC 27064] Length=306 Score = 275 bits (702), Expect = 8e-72, Method: Compositional matrix adjust. Identities = 167/294 (57%), Positives = 203/294 (70%), Gaps = 4/294 (1%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 L+ DGGL+ +L A+G DLSDPLW+ARLL D P + A HTAY AGAQ+ +ASYQAS E Sbjct 16 LVLDGGLSNQLAAQGCDLSDPLWTARLLKDGPEQLAAAHTAYADAGAQVLISASYQASHE 75 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGL 128 GF G+G +++ LL RSVELA+AA D + VAASVGPYGA LADGSEYRG YGL Sbjct 76 GFRRAGLGGAESSALLARSVELARAAADAAPAE-VWVAASVGPYGAVLADGSEYRGRYGL 134 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 +V L ++H PR+E L AG D+LALET+PD DEA+AL+ P WLSYT +G RT Sbjct 135 TVRELERFHRPRIEALAAAGPDVLALETVPDTDEAKALLAAAADCGVPVWLSYTADGDRT 194 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQPL DAFA+AA +++A GVNCCAP D PA+A A + TG+PV+VYPNSGE WD Sbjct 195 RAGQPLADAFALAAEHEQVIATGVNCCAPRDAAPAVARAASVTGRPVVVYPNSGEDWDPA 254 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG 302 W GP R+ + A WV AGAR++GGCCRV P IAE+ L P G Sbjct 255 AHTWRGPVRYDPAQ---APAWVTAGARLIGGCCRVGPATIAELASFLWLGSPPG 305 >gi|326776008|ref|ZP_08235273.1| Homocysteine S-methyltransferase [Streptomyces cf. griseus XylebKG-1] gi|326656341|gb|EGE41187.1| Homocysteine S-methyltransferase [Streptomyces griseus XylebKG-1] Length=305 Score = 274 bits (701), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 162/287 (57%), Positives = 189/287 (66%), Gaps = 7/287 (2%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ +LEA+G DLSD LWSARLL DAP I A H AY RAGA++ TASYQA+FE Sbjct 16 VLLDGGLSNQLEAQGCDLSDALWSARLLADAPEQIEAAHLAYLRAGARVLITASYQATFE 75 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS----VAASVGPYGAALADGSEYRG 124 GF G+ LL RSVELA+ A D VAASVGPYGA LADGSEYRG Sbjct 76 GFGRYGLDRAATGALLARSVELARGAADAARRADPGREAWVAASVGPYGAMLADGSEYRG 135 Query 125 YYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTIN 184 YGLSV L ++H PR+ L AG D LALET+PD+DEAEALV + P WLSY++ Sbjct 136 RYGLSVRELERFHRPRVAALAAAGPDALALETVPDLDEAEALVRVAEETGLPYWLSYSVA 195 Query 185 GTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEG 244 RTRAGQPL +AFAVAAG ++AVGVNCC P + A+ AVA TG+P +VYPNSGEG Sbjct 196 DGRTRAGQPLQEAFAVAAGRDSVLAVGVNCCDPQEAQGAVEQAVAVTGRPAVVYPNSGEG 255 Query 245 WDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEI 291 WD R W G F R W AGA +VGGCCRV P I E+ Sbjct 256 WDAGARGWTGHGTFDPGR---VRAWTRAGAGLVGGCCRVGPDLITEL 299 >gi|295835182|ref|ZP_06822115.1| homocysteine S-methyltransferase [Streptomyces sp. SPB74] gi|197697892|gb|EDY44825.1| homocysteine S-methyltransferase [Streptomyces sp. SPB74] Length=304 Score = 271 bits (694), Expect = 7e-71, Method: Compositional matrix adjust. Identities = 159/280 (57%), Positives = 187/280 (67%), Gaps = 9/280 (3%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL+ ELEA GH L+D LWSARLL D P A+TA H AY AGA++ATTASYQASFE Sbjct 23 VVLDGGLSNELEAAGHGLADALWSARLLRDGPAALTAAHRAYASAGAEVATTASYQASFE 82 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYGL 128 GFA I LL SV A+A+ G VAASVGPYGA LADGSEYRG YG+ Sbjct 83 GFARHRIDAARTRELLALSVAAARAS------GSRWVAASVGPYGAMLADGSEYRGRYGV 136 Query 129 SVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTRT 188 A L ++H PR+E L+ AG D+LALET+PD +EA AL+ +VR P WLSY++ T Sbjct 137 GRAELERFHGPRVEALLAAGPDVLALETVPDTEEARALLAVVRGCGVPVWLSYSVADGAT 196 Query 189 RAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWDGR 248 RAGQPL AF +AA EIVAVGVNCCAP +V A+ AVA GKP + YPNSGE WD Sbjct 197 RAGQPLDAAFGLAAEAEEIVAVGVNCCAPGEVADAVRRAVAAGGKPGVAYPNSGERWDAH 256 Query 249 RRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDI 288 R W F LA W AAGAR++GGCCRV P +I Sbjct 257 ARGWRSDPSFVPG---LAARWYAAGARLIGGCCRVGPGEI 293 >gi|326333481|ref|ZP_08199723.1| homocysteine S-methyltransferase [Nocardioidaceae bacterium Broad-1] gi|325948726|gb|EGD40824.1| homocysteine S-methyltransferase [Nocardioidaceae bacterium Broad-1] Length=287 Score = 271 bits (692), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 164/290 (57%), Positives = 197/290 (68%), Gaps = 10/290 (3%) Query 8 VLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASF 67 V I DGGL+ LEARGHD+S LW+ARLL ++P I AVH AY+ AGA +ATTASYQAS Sbjct 2 VTILDGGLSNALEARGHDVSGALWTARLLDESPAEIAAVHRAYYAAGADVATTASYQASV 61 Query 68 EGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGYYG 127 GF G+ AT LLRRSV +A+ E G G L VAASVGPYGA LADGSEYRG YG Sbjct 62 PGFVEAGMTETYATELLRRSVRIAREVAAE-GPGRL-VAASVGPYGAYLADGSEYRGRYG 119 Query 128 LSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTINGTR 187 +S A L +H PRL +L D++A+ETIPDI+EAE LV+L+ + P W SY+ GTR Sbjct 120 VSAATLRDFHAPRLALLETEDPDLIAVETIPDIEEAEVLVDLLDDIGLPVWFSYSCAGTR 179 Query 188 TRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGW-D 246 TRAGQPL DA A+AAG+ +VAVGVNCC P DV A+ A A TG+P +VYPN+GE + D Sbjct 180 TRAGQPLADALALAAGIRSVVAVGVNCCDPADVPAAVQLATA-TGEPAVVYPNTGETYAD 238 Query 247 GRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALT 296 G AW G F A WV++GA VGGCCRV P +IA I L+ Sbjct 239 G---AWTGTPHFRPGE---ALSWVSSGAAYVGGCCRVGPAEIALIAAELS 282 >gi|302523430|ref|ZP_07275772.1| homocysteine methyltransferase [Streptomyces sp. SPB78] gi|302432325|gb|EFL04141.1| homocysteine methyltransferase [Streptomyces sp. SPB78] Length=304 Score = 270 bits (691), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 161/288 (56%), Positives = 191/288 (67%), Gaps = 9/288 (3%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 V + + ++ DGGL+ ELEA GH L+D LWSARLL D P A+T H AY AGA++ATT Sbjct 15 VRALGERAVVLDGGLSNELEAAGHGLADALWSARLLRDEPAALTEAHRAYAEAGAEVATT 74 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 ASYQASFEGFA GI LL SV A+AA G VAASVGPYGA LADGS Sbjct 75 ASYQASFEGFARHGIDAARTRELLALSVTAARAA------GSRWVAASVGPYGAMLADGS 128 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YG+ AAL ++H PR+E L+ AG D+LALET+PD +EA AL+ +VR P WLS Sbjct 129 EYRGRYGVGRAALERFHGPRVEALLAAGPDVLALETVPDAEEARALLAVVRGCGVPVWLS 188 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 Y++ RT AGQPL AF +AA E+VAVGVNCC P +V A+ AVA +GKP + YPN Sbjct 189 YSVADGRTWAGQPLDAAFGLAAEAEEVVAVGVNCCEPLEVADAVRRAVAVSGKPGVAYPN 248 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDI 288 SGE WD R W F +LA W AAGAR+VGGCCRV P I Sbjct 249 SGERWDAHARGWRSDPSF---VPELAARWYAAGARLVGGCCRVGPDGI 293 >gi|332529802|ref|ZP_08405756.1| homocysteine methyltransferase [Hylemonella gracilis ATCC 19624] gi|332040823|gb|EGI77195.1| homocysteine methyltransferase [Hylemonella gracilis ATCC 19624] Length=322 Score = 270 bits (690), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 151/302 (50%), Positives = 192/302 (64%), Gaps = 11/302 (3%) Query 3 LVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS 62 L + + DG LATELE RG DL DPLWSA+LL++ P I VH YF AGA ++TTAS Sbjct 12 LDEQGLFVLDGALATELERRGADLKDPLWSAKLLIEQPDLIRQVHLDYFVAGADVSTTAS 71 Query 63 YQASFEGFAARGIGHDDATVLLRRSVELAQAARD--------EVGVGGLSVAASVGPYGA 114 YQA+FE FA RG+GHD+A L+RRSV+LA ARD G VAASVGPYGA Sbjct 72 YQATFEAFARRGLGHDEAADLMRRSVQLACEARDAFWSDPKHRAGRRKPLVAASVGPYGA 131 Query 115 ALADGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRL- 173 LADGSEYRGY G+S AAL +H PRL+VL +GAD+LA ET+P + EA A+ +L+ Sbjct 132 MLADGSEYRGYPGVSRAALAAFHRPRLQVLAHSGADLLACETLPCLAEALAITDLLPEFP 191 Query 174 ATPAWLSYTI-NGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTG 232 AW+S++ +G G+PL D A VP++ AVGVNC AP+ V + A A T Sbjct 192 GVQAWISFSCRDGEHNSQGEPLADCVAALDPVPQVAAVGVNCTAPEFVPSLVERARARTS 251 Query 233 KPVIVYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIG 292 KP++VYPNSGE +D + W G + + Q R W GAR++GGCCR P DI + Sbjct 252 KPIVVYPNSGEHYDAVGKVWQGEGQAHDFAAQAMR-WHNRGARLIGGCCRTGPDDIRALR 310 Query 293 RA 294 +A Sbjct 311 QA 312 >gi|336120795|ref|YP_004575581.1| homocysteine S-methyltransferase [Microlunatus phosphovorus NM-1] gi|334688593|dbj|BAK38178.1| homocysteine S-methyltransferase [Microlunatus phosphovorus NM-1] Length=310 Score = 268 bits (684), Expect = 9e-70, Method: Compositional matrix adjust. Identities = 151/292 (52%), Positives = 198/292 (68%), Gaps = 5/292 (1%) Query 9 LISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFE 68 ++ DGGL TELE+ G D++ LWS +LL+DAP + A H +F AGAQ+A + SYQ SFE Sbjct 17 VLMDGGLGTELESSGCDVTGILWSGQLLLDAPEVVEAAHRRFFAAGAQVAISGSYQLSFE 76 Query 69 GFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLS-VAASVGPYGAALADGSEYRGYYG 127 G AA G+ A +LRRSV +A AAR+ + VAASVGPYGA LADGSE+RG YG Sbjct 77 GLAAVGVDRAAAETMLRRSVAVASAAREAAVDPDQTWVAASVGPYGATLADGSEFRGTYG 136 Query 128 LSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLSYTI-NGT 186 +V L +WH PRL VL +AGAD+LA+ETIP + E EAL+ + P+WLS T + T Sbjct 137 KTVTELQQWHRPRLTVLAEAGADVLAIETIPCLAEVEALLRDIDGSGVPSWLSLTCASAT 196 Query 187 RTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPNSGEGWD 246 TRAG+P+ +AFA+AA V E++AVGVNC P D +A A +GKPV+VYPNSGE WD Sbjct 197 TTRAGEPVAEAFAMAADVAEVIAVGVNCLPPGDARDLVATAARSSGKPVVVYPNSGEEWD 256 Query 247 GRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTA 298 ++W G +G++A W+A GAR+VGGCCRVRP +I ++ L+ A Sbjct 257 AVHKSWYGDGSL--LAGEIAG-WLADGARLVGGCCRVRPAEIEKLAAELSAA 305 >gi|318058173|ref|ZP_07976896.1| homocysteine methyltransferase [Streptomyces sp. SA3_actG] gi|318078928|ref|ZP_07986260.1| homocysteine methyltransferase [Streptomyces sp. SA3_actF] Length=304 Score = 266 bits (679), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 161/288 (56%), Positives = 193/288 (68%), Gaps = 9/288 (3%) Query 1 VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT 60 V + + ++ DGGL+ ELEA GH L+D LWSARLL D P A+T H AY AGA++ATT Sbjct 15 VRALGERAVVLDGGLSNELEAAGHGLADALWSARLLRDEPAALTGAHRAYAEAGAEVATT 74 Query 61 ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS 120 ASYQASFEGFA GI LL SV A+AA G VAASVGPYGA LADGS Sbjct 75 ASYQASFEGFARHGIDAARTRELLALSVTAARAA------GSRWVAASVGPYGAMLADGS 128 Query 121 EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS 180 EYRG YG+ AAL ++H PR++ L+ AG D+LALET+PD +EA AL+ +VR P WLS Sbjct 129 EYRGRYGVGRAALERFHGPRVDALLAAGPDVLALETVPDAEEARALLAVVRGCGVPVWLS 188 Query 181 YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN 240 Y++ RTRAGQPL AF +AA E+VAVGVNCC P +V A+ AVA +GKP + YPN Sbjct 189 YSVADGRTRAGQPLDAAFGLAAEAEEVVAVGVNCCEPLEVADAVRRAVAASGKPGVAYPN 248 Query 241 SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDI 288 SGE WD R W F +LA +W AAGAR+VGGCCRV P I Sbjct 249 SGERWDAHARGWRSDPSF---VPELAAQWYAAGARLVGGCCRVGPDGI 293 >gi|261822177|ref|YP_003260283.1| homocysteine methyltransferase [Pectobacterium wasabiae WPP163] gi|261606190|gb|ACX88676.1| homocysteine S-methyltransferase [Pectobacterium wasabiae WPP163] Length=313 Score = 265 bits (677), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 143/298 (48%), Positives = 184/298 (62%), Gaps = 7/298 (2%) Query 3 LVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTAS 62 L + S ++ DG LATELEARG DL+DPLWSA++LV+ P I VH YF AGAQ A TAS Sbjct 10 LATASTIVLDGALATELEARGCDLTDPLWSAKVLVENPALIYQVHLDYFNAGAQCAITAS 69 Query 63 YQASFEGFAARGIGHDDATVLLRRSVELAQAARDEV-----GVGGLSVAASVGPYGAALA 117 YQA+ +GF ARG ++ L+ +SV+LA ARD+ G L VA SVGPYGA LA Sbjct 70 YQATPQGFKARGYSEAESLTLIAKSVQLAAQARDDYRRDNSQAGVLLVAGSVGPYGAYLA 129 Query 118 DGSEYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRL-ATP 176 DGSEYRG Y L A +M +H PR+ L +AGAD+LA ET+P E EAL+ L+ Sbjct 130 DGSEYRGDYQLPQAEMMAFHRPRIAALHEAGADLLACETLPSFAEVEALIALLAEFPQAQ 189 Query 177 AWLSYTINGTRTRA-GQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPV 235 AW S+T+ + + G PL P++VAVG+NC A ++V PA+ + T P+ Sbjct 190 AWFSFTLRDSEHLSDGTPLHTVLERVNACPQVVAVGINCIALENVTPALTYLSLLTNLPL 249 Query 236 IVYPNSGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGR 293 +VYPNSGE +D + W + S EW AAGAR++GGCCR P DIA I R Sbjct 250 VVYPNSGEQYDAVTKTWSSAHDAACSLAAYLPEWQAAGARLIGGCCRTTPADIAGIAR 307 Lambda K H 0.320 0.135 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 505781532318 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40