BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv2527

Length=133
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|167967328|ref|ZP_02549605.1|  hypothetical protein MtubH3_0454...   272    1e-71
gi|15609664|ref|NP_217043.1|  hypothetical protein Rv2527 [Mycoba...   271    2e-71
gi|340627542|ref|YP_004745994.1|  hypothetical protein MCAN_25671...   269    1e-70
gi|333992736|ref|YP_004525350.1|  hypothetical protein JDM601_409...   192    1e-47
gi|336120115|ref|YP_004574893.1|  hypothetical protein MLP_44760 ...   160    6e-38
gi|302536099|ref|ZP_07288441.1|  conserved hypothetical protein [...  72.8    2e-11
gi|254383838|ref|ZP_04999186.1|  conserved hypothetical protein [...  68.2    4e-10
gi|315504329|ref|YP_004083216.1|  pilt protein domain-containing ...  66.2    2e-09
gi|302869194|ref|YP_003837831.1|  PilT protein domain-containing ...  64.7    4e-09
gi|311897824|dbj|BAJ30232.1|  hypothetical protein KSE_44490 [Kit...  64.3    5e-09
gi|15842082|ref|NP_337119.1|  hypothetical protein MT2622 [Mycoba...  62.8    2e-08
gi|167968845|ref|ZP_02551122.1|  hypothetical protein MtubH3_1276...  62.8    2e-08
gi|15609683|ref|NP_217062.1|  hypothetical protein Rv2546 [Mycoba...  62.8    2e-08
gi|339295424|gb|AEJ47535.1|  hypothetical protein CCDC5079_2345 [...  62.8    2e-08
gi|306780585|ref|ZP_07418922.1|  toxin [Mycobacterium tuberculosi...  61.6    3e-08
gi|294629978|ref|ZP_06708538.1|  PIN family toxin-antitoxin syste...  61.6    4e-08
gi|297160784|gb|ADI10496.1|  hypothetical protein SBI_07376 [Stre...  60.8    6e-08
gi|302559325|ref|ZP_07311667.1|  PIN family toxin-antitoxin syste...  60.5    7e-08
gi|345013748|ref|YP_004816102.1|  PilT protein domain-containing ...  59.7    1e-07
gi|291452355|ref|ZP_06591745.1|  conserved hypothetical protein [...  59.7    1e-07
gi|340627758|ref|YP_004746210.1|  hypothetical protein MCAN_27841...  58.2    4e-07
gi|290958509|ref|YP_003489691.1|  hypothetical protein SCAB_40681...  57.8    6e-07
gi|239988547|ref|ZP_04709211.1|  hypothetical protein SrosN1_1465...  57.0    9e-07
gi|343479040|gb|AEM44209.1|  hypothetical protein [uncultured bac...  56.6    1e-06
gi|297154824|gb|ADI04536.1|  hypothetical protein SBI_01415 [Stre...  55.8    2e-06
gi|308378090|ref|ZP_07668665.1|  putative type I restriction-modi...  55.8    2e-06
gi|302544584|ref|ZP_07296926.1|  PIN family toxin-antitoxin syste...  55.1    4e-06
gi|15609894|ref|NP_217273.1|  hypothetical protein Rv2757c [Mycob...  54.7    4e-06
gi|328882585|emb|CCA55824.1|  hypothetical protein SVEN_2538 [Str...  53.9    8e-06
gi|284045212|ref|YP_003395552.1|  PilT protein domain protein [Co...  53.1    1e-05
gi|284991226|ref|YP_003409780.1|  PilT protein domain-containing ...  52.8    2e-05
gi|302557955|ref|ZP_07310297.1|  PIN family toxin-antitoxin syste...  52.0    3e-05
gi|302534504|ref|ZP_07286846.1|  predicted protein [Streptomyces ...  49.3    2e-04
gi|315446124|ref|YP_004079003.1|  nucleic acid-binding protein, c...  48.5    3e-04
gi|292491388|ref|YP_003526827.1|  PilT protein domain protein [Ni...  48.5    3e-04
gi|145225766|ref|YP_001136444.1|  PilT domain-containing protein ...  48.1    4e-04
gi|336119997|ref|YP_004574775.1|  hypothetical protein MLP_43580 ...  47.0    0.001
gi|254388989|ref|ZP_05004220.1|  conserved membrane protein [Stre...  46.2    0.002
gi|302552928|ref|ZP_07305270.1|  conserved hypothetical protein [...  45.4    0.002
gi|289748705|ref|ZP_06508083.1|  LOW QUALITY PROTEIN: conserved m...  44.7    0.005
gi|302559520|ref|ZP_07311862.1|  PIN family toxin-antitoxin syste...  44.7    0.005
gi|29832237|ref|NP_826871.1|  hypothetical protein SAV_5694 [Stre...  44.3    0.007
gi|289572808|ref|ZP_06453035.1|  toxin [Mycobacterium tuberculosi...  44.3    0.007
gi|167968774|ref|ZP_02551051.1|  hypothetical protein MtubH3_1235...  43.9    0.008
gi|15607370|ref|NP_214743.1|  hypothetical protein Rv0229c [Mycob...  43.9    0.008
gi|239990082|ref|ZP_04710746.1|  hypothetical protein SrosN1_2244...  43.1    0.014
gi|295840079|ref|ZP_06827012.1|  PIN family toxin-antitoxin syste...  43.1    0.015
gi|289445761|ref|ZP_06435505.1|  toxin [Mycobacterium tuberculosi...  42.0    0.029
gi|315441643|ref|YP_004074520.1|  nucleic acid-binding protein, c...  42.0    0.035
gi|297199892|ref|ZP_06917289.1|  conserved hypothetical protein [...  41.6    0.043


>gi|167967328|ref|ZP_02549605.1| hypothetical protein MtubH3_04542 [Mycobacterium tuberculosis 
H37Ra]
 gi|254551575|ref|ZP_05142022.1| toxin [Mycobacterium tuberculosis '98-R604 INH-RIF-EM']
 gi|308232164|ref|ZP_07415137.2| toxin [Mycobacterium tuberculosis SUMu001]
 21 more sequence titles
 Length=135

 Score =  272 bits (695),  Expect = 1e-71, Method: Compositional matrix adjust.
 Identities = 133/133 (100%), Positives = 133/133 (100%), Gaps = 0/133 (0%)

Query  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ
Sbjct  3    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ  62

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
            ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV
Sbjct  63   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  122

Query  121  RPGFQACELSRGR  133
            RPGFQACELSRGR
Sbjct  123  RPGFQACELSRGR  135


>gi|15609664|ref|NP_217043.1| hypothetical protein Rv2527 [Mycobacterium tuberculosis H37Rv]
 gi|15842061|ref|NP_337098.1| hypothetical protein MT2602 [Mycobacterium tuberculosis CDC1551]
 gi|31793708|ref|NP_856201.1| hypothetical protein Mb2556 [Mycobacterium bovis AF2122/97]
 53 more sequence titles
 Length=133

 Score =  271 bits (693),  Expect = 2e-71, Method: Compositional matrix adjust.
 Identities = 133/133 (100%), Positives = 133/133 (100%), Gaps = 0/133 (0%)

Query  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ
Sbjct  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
            ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV
Sbjct  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120

Query  121  RPGFQACELSRGR  133
            RPGFQACELSRGR
Sbjct  121  RPGFQACELSRGR  133


>gi|340627542|ref|YP_004745994.1| hypothetical protein MCAN_25671 [Mycobacterium canettii CIPT 
140010059]
 gi|340005732|emb|CCC44898.1| conserved hypothetical protein [Mycobacterium canettii CIPT 140010059]
Length=133

 Score =  269 bits (687),  Expect = 1e-70, Method: Compositional matrix adjust.
 Identities = 131/133 (99%), Positives = 132/133 (99%), Gaps = 0/133 (0%)

Query  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ
Sbjct  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
            ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETA+HHRAGVLHHDRDYKRIA V
Sbjct  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETAIHHRAGVLHHDRDYKRIAAV  120

Query  121  RPGFQACELSRGR  133
            RPGFQACELSRGR
Sbjct  121  RPGFQACELSRGR  133


>gi|333992736|ref|YP_004525350.1| hypothetical protein JDM601_4096 [Mycobacterium sp. JDM601]
 gi|333488704|gb|AEF38096.1| conserved hypothetical protein [Mycobacterium sp. JDM601]
Length=131

 Score =  192 bits (488),  Expect = 1e-47, Method: Compositional matrix adjust.
 Identities = 96/130 (74%), Positives = 106/130 (82%), Gaps = 1/130 (0%)

Query  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLR-AY  59
            MT W+LDKSAHVRLV GA  P  IDL D+A+C++ ELEWLYSARS  DYDSQ  ++R AY
Sbjct  1    MTRWLLDKSAHVRLVGGAALPDDIDLADVALCEMSELEWLYSARSGADYDSQSAAVRDAY  60

Query  60   QILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAV  119
             +L AP+DIFDRVR LQRDLAHHRGMWHRTPLPDLFIAETALHH AGVLH DRDY+RI  
Sbjct  61   PVLPAPADIFDRVRRLQRDLAHHRGMWHRTPLPDLFIAETALHHGAGVLHRDRDYQRIRK  120

Query  120  VRPGFQACEL  129
            VR  FQ  EL
Sbjct  121  VRSDFQVREL  130


>gi|336120115|ref|YP_004574893.1| hypothetical protein MLP_44760 [Microlunatus phosphovorus NM-1]
 gi|334687905|dbj|BAK37490.1| hypothetical protein MLP_44760 [Microlunatus phosphovorus NM-1]
Length=132

 Score =  160 bits (405),  Expect = 6e-38, Method: Compositional matrix adjust.
 Identities = 79/125 (64%), Positives = 93/125 (75%), Gaps = 1/125 (0%)

Query  1    MTTWILDKSAHVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLR-AY  59
            +  WI+DKSAHVRL+ G+  PAGI    LAIC++G LEWLYSARSA DYD+Q T LR  +
Sbjct  3    LNLWIIDKSAHVRLIGGSPLPAGISPARLAICEMGLLEWLYSARSALDYDTQHTELREMF  62

Query  60   QILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAV  119
             I+ AP++IFDRV  LQ DLAHHR MWHR  L DLFIAETAL H+AGVLH D D++ I  
Sbjct  63   HIVEAPANIFDRVLQLQADLAHHRSMWHRRALGDLFIAETALAHQAGVLHADSDFELIQQ  122

Query  120  VRPGF  124
            VRP  
Sbjct  123  VRPNL  127


>gi|302536099|ref|ZP_07288441.1| conserved hypothetical protein [Streptomyces sp. C]
 gi|302444994|gb|EFL16810.1| conserved hypothetical protein [Streptomyces sp. C]
Length=138

 Score = 72.8 bits (177),  Expect = 2e-11, Method: Compositional matrix adjust.
 Identities = 42/92 (46%), Positives = 51/92 (56%), Gaps = 1/92 (1%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            L +C   ELE LYSARS  D D  +  L A+  L  P +++DR   +Q+ L    G W  
Sbjct  33   LGVCGAVELEVLYSARSKGDADRVRAGLGAFAWLSTPDEVWDRALDVQKQLIVA-GNWKA  91

Query  89   TPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              LPDL IA TA  H A VLH+D DY  IA V
Sbjct  92   VSLPDLVIAATAERHGATVLHYDGDYDMIAEV  123


>gi|254383838|ref|ZP_04999186.1| conserved hypothetical protein [Streptomyces sp. Mg1]
 gi|194342731|gb|EDX23697.1| conserved hypothetical protein [Streptomyces sp. Mg1]
Length=138

 Score = 68.2 bits (165),  Expect = 4e-10, Method: Compositional matrix adjust.
 Identities = 40/92 (44%), Positives = 49/92 (54%), Gaps = 1/92 (1%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            LA+C   ELE +YSARS  D    +  + A+  L  P + +DR   +Q D     G W  
Sbjct  33   LAVCGAVELEVMYSARSKADARRVREGMAAFDWLPTPDEAWDRALEVQ-DALIGEGNWKA  91

Query  89   TPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              LPDL IA TA  H A VLH+D DY  IA V
Sbjct  92   VSLPDLIIAATAERHGATVLHYDGDYDMIAAV  123


>gi|315504329|ref|YP_004083216.1| pilt protein domain-containing protein [Micromonospora sp. L5]
 gi|315410948|gb|ADU09065.1| PilT protein domain protein [Micromonospora sp. L5]
Length=139

 Score = 66.2 bits (160),  Expect = 2e-09, Method: Compositional matrix adjust.
 Identities = 46/120 (39%), Positives = 63/120 (53%), Gaps = 4/120 (3%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            ++LDKSA  R    A  P   +L+D   LA+C   E+E ++SARSA D    +  LR + 
Sbjct  6    YLLDKSALARWPKPAVAPVLDELSDRGLLAVCGAIEIEVVHSARSAKDAKRARWLLRGFD  65

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
             L  P DI+DR   +Q   A H+G      + DL IA TA  H   VLH+D D+  I  +
Sbjct  66   WLAMPDDIWDRAIDIQVQ-ALHKGNHRALSMADLLIAATAERHGVTVLHYDGDFDLITAI  124


>gi|302869194|ref|YP_003837831.1| PilT protein domain-containing protein [Micromonospora aurantiaca 
ATCC 27029]
 gi|302572053|gb|ADL48255.1| PilT protein domain protein [Micromonospora aurantiaca ATCC 27029]
Length=139

 Score = 64.7 bits (156),  Expect = 4e-09, Method: Compositional matrix adjust.
 Identities = 45/120 (38%), Positives = 62/120 (52%), Gaps = 4/120 (3%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            ++LDKSA  R    A  P   +L+D   LA+C   E+E ++SARSA D    +  LR + 
Sbjct  6    YLLDKSALARWPKPAVAPVLDELSDRGLLAVCGAIEIEVIHSARSAKDAKRARWLLRGFD  65

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
             L  P DI+DR   +Q     H+G      + DL IA TA  H   VLH+D D+  I  +
Sbjct  66   WLAMPDDIWDRAIDIQVQ-TLHKGNHRALSMADLLIAATAERHGVTVLHYDGDFDLITAI  124


>gi|311897824|dbj|BAJ30232.1| hypothetical protein KSE_44490 [Kitasatospora setae KM-6054]
Length=139

 Score = 64.3 bits (155),  Expect = 5e-09, Method: Compositional matrix adjust.
 Identities = 44/120 (37%), Positives = 63/120 (53%), Gaps = 4/120 (3%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            +++DKSA  R    A  P   DL+    LAI    E+E LYSAR+  + +  +  LR + 
Sbjct  6    FLIDKSALARWGKPAVRPVLDDLSQRALLAISPTVEMEVLYSARTLAEAERLRHLLRGFD  65

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
             L  P +++DR + +Q+  A  RG      + DL IA TA  H   VLH+D DY  IA +
Sbjct  66   YLSCPDEVWDRAKQVQQQ-ALFRGNHRALSMADLLIAATAERHGVTVLHYDGDYDMIAAI  124


>gi|15842082|ref|NP_337119.1| hypothetical protein MT2622 [Mycobacterium tuberculosis CDC1551]
 gi|254551596|ref|ZP_05142043.1| hypothetical protein Mtube_14247 [Mycobacterium tuberculosis 
'98-R604 INH-RIF-EM']
 gi|289746329|ref|ZP_06505707.1| conserved hypothetical protein [Mycobacterium tuberculosis 02_1987]
 7 more sequence titles
 Length=138

 Score = 62.8 bits (151),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 1/100 (1%)

Query  22   AGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAH  81
            A +    + ICD   LE LYSA SATDYD+    L     +   ++ F R   +QR+LAH
Sbjct  25   AALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRELAH  84

Query  82   HRGMWHRT-PLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              G+ HR+  + DL IA  A      V H+D +Y R+A +
Sbjct  85   VAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAI  124


>gi|167968845|ref|ZP_02551122.1| hypothetical protein MtubH3_12760 [Mycobacterium tuberculosis 
H37Ra]
Length=136

 Score = 62.8 bits (151),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 1/100 (1%)

Query  22   AGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAH  81
            A +    + ICD   LE LYSA SATDYD+    L     +   ++ F R   +QR+LAH
Sbjct  23   AALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRELAH  82

Query  82   HRGMWHRT-PLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              G+ HR+  + DL IA  A      V H+D +Y R+A +
Sbjct  83   VAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAI  122


>gi|15609683|ref|NP_217062.1| hypothetical protein Rv2546 [Mycobacterium tuberculosis H37Rv]
 gi|31793729|ref|NP_856222.1| hypothetical protein Mb2576 [Mycobacterium bovis AF2122/97]
 gi|121638431|ref|YP_978655.1| hypothetical protein BCG_2569 [Mycobacterium bovis BCG str. Pasteur 
1173P2]
 55 more sequence titles
 Length=137

 Score = 62.8 bits (151),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 38/100 (38%), Positives = 53/100 (53%), Gaps = 1/100 (1%)

Query  22   AGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAH  81
            A +    + ICD   LE LYSA SATDYD+    L     +   ++ F R   +QR+LAH
Sbjct  24   AALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRELAH  83

Query  82   HRGMWHRT-PLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              G+ HR+  + DL IA  A      V H+D +Y R+A +
Sbjct  84   VAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAI  123


>gi|339295424|gb|AEJ47535.1| hypothetical protein CCDC5079_2345 [Mycobacterium tuberculosis 
CCDC5079]
Length=112

 Score = 62.8 bits (151),  Expect = 2e-08, Method: Compositional matrix adjust.
 Identities = 37/93 (40%), Positives = 51/93 (55%), Gaps = 1/93 (1%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            + ICD   LE LYSA SATDYD+    L     +   ++ F R   +QR+LAH  G+ HR
Sbjct  6    IGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRELAHVAGLHHR  65

Query  89   T-PLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
            +  + DL IA  A      V H+D +Y R+A +
Sbjct  66   SVKIADLVIAAAAELSGTIVWHYDENYDRVAAI  98


>gi|306780585|ref|ZP_07418922.1| toxin [Mycobacterium tuberculosis SUMu002]
 gi|306785348|ref|ZP_07423670.1| toxin [Mycobacterium tuberculosis SUMu003]
 gi|306789947|ref|ZP_07428269.1| toxin [Mycobacterium tuberculosis SUMu004]
 13 more sequence titles
 Length=137

 Score = 61.6 bits (148),  Expect = 3e-08, Method: Compositional matrix adjust.
 Identities = 38/100 (38%), Positives = 52/100 (52%), Gaps = 1/100 (1%)

Query  22   AGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAH  81
            A +    + ICD   LE LYSA SATDYD+    L     +   +  F R   +QR+LAH
Sbjct  24   AALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAKTFTRACQVQRELAH  83

Query  82   HRGMWHRT-PLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              G+ HR+  + DL IA  A      V H+D +Y R+A +
Sbjct  84   VAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAI  123


>gi|294629978|ref|ZP_06708538.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
sp. e14]
 gi|292833311|gb|EFF91660.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
sp. e14]
Length=134

 Score = 61.6 bits (148),  Expect = 4e-08, Method: Compositional matrix adjust.
 Identities = 53/129 (42%), Positives = 69/129 (54%), Gaps = 11/129 (8%)

Query  3    TWILDKSAHVRLVAG--ATP-PAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSL-RA  58
            T++ D SA  RL+ G   +P P       LAIC   E E +   RS  DY+   T L + 
Sbjct  2    TYLADTSAVWRLLRGQLGSPWPDRAARGLLAICPPVEAELMPGLRSDRDYEPFFTVLSQT  61

Query  59   YQILRAPSDIFDRVRHLQRDLA---HHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYK  115
            +  + AP D + +V  +QRDLA   HHRG    +P+ D+ IA TA HH   VLH D D+ 
Sbjct  62   FGRVPAPDDPWQKVLGVQRDLARIGHHRG---PSPM-DILIALTAEHHHLTVLHVDDDFA  117

Query  116  RIAVVRPGF  124
             IA VRPG 
Sbjct  118  AIAKVRPGI  126


>gi|297160784|gb|ADI10496.1| hypothetical protein SBI_07376 [Streptomyces bingchenggensis 
BCW-1]
Length=138

 Score = 60.8 bits (146),  Expect = 6e-08, Method: Compositional matrix adjust.
 Identities = 37/92 (41%), Positives = 48/92 (53%), Gaps = 1/92 (1%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            LA+C   ELE L+SARS  D +  +  +R +  L  P + +DR   +Q  L    G W  
Sbjct  33   LAVCGAVELEVLHSARSKGDAERIRDEMRGFDWLPTPDEAWDRALEVQTQLIAA-GNWKA  91

Query  89   TPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              + DL IA TA  H   VLH+D DY  IA V
Sbjct  92   LSVSDLVIAATAERHSVIVLHYDGDYDMIAAV  123


>gi|302559325|ref|ZP_07311667.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
griseoflavus Tu4000]
 gi|302476943|gb|EFL40036.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
griseoflavus Tu4000]
Length=139

 Score = 60.5 bits (145),  Expect = 7e-08, Method: Compositional matrix adjust.
 Identities = 47/132 (36%), Positives = 64/132 (49%), Gaps = 13/132 (9%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            +++DKSA  R    +       L +   LA+C   E E ++SAR +++     T L A+ 
Sbjct  5    YLIDKSALARWTKPSVKEVLKPLHERYLLAVCQPTEYEMIHSARDSSEATRISTWLHAFD  64

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA--  118
             LR   D+F R   +QR  A + G      LPDL IA TA  HR  VLH+D D+  IA  
Sbjct  65   YLRTDDDVFTRALEIQRH-ALNAGFHRALSLPDLLIAATAELHRRTVLHYDGDFDMIASL  123

Query  119  -------VVRPG  123
                   VV PG
Sbjct  124  TGQPAEWVVAPG  135


>gi|345013748|ref|YP_004816102.1| PilT protein domain-containing protein [Streptomyces violaceusniger 
Tu 4113]
 gi|344040097|gb|AEM85822.1| PilT protein domain protein [Streptomyces violaceusniger Tu 4113]
Length=139

 Score = 59.7 bits (143),  Expect = 1e-07, Method: Compositional matrix adjust.
 Identities = 34/92 (37%), Positives = 49/92 (54%), Gaps = 1/92 (1%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            LA+C   E+E +YSAR+  D       L  +  L  P +++DR + +QR  A  +G    
Sbjct  33   LAVCGPVEMEVMYSARNDNDAKRLHWFLSGFDYLPMPDEVWDRAKDIQRQ-AITKGNHRA  91

Query  89   TPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              +PDL IA  A  H   VLH+D+DY  IA +
Sbjct  92   LSMPDLLIAAAAERHAVTVLHYDQDYDMIAAI  123


>gi|291452355|ref|ZP_06591745.1| conserved hypothetical protein [Streptomyces albus J1074]
 gi|291355304|gb|EFE82206.1| conserved hypothetical protein [Streptomyces albus J1074]
Length=135

 Score = 59.7 bits (143),  Expect = 1e-07, Method: Compositional matrix adjust.
 Identities = 41/122 (34%), Positives = 63/122 (52%), Gaps = 12/122 (9%)

Query  4    WILDKSAHVRLVAGATP-------PAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSL  56
            +++D SA VR++    P        AG+    +++CD+ ELE LYSARS +D D+ +  L
Sbjct  6    YLIDTSALVRVLQRRVPREWEHRIGAGL----VSLCDLTELELLYSARSTSDRDAIRDRL  61

Query  57   RAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKR  116
              +     P  +F R R +Q  L   +G        DL +A TA      +LHHDRD++ 
Sbjct  62   SLFTWCPMPDGVFRRARTVQA-LLTDKGEHRSAGAVDLLLAATAEQSGLTLLHHDRDFET  120

Query  117  IA  118
            +A
Sbjct  121  VA  122


>gi|340627758|ref|YP_004746210.1| hypothetical protein MCAN_27841 [Mycobacterium canettii CIPT 
140010059]
 gi|340005948|emb|CCC45115.1| conserved hypothetical protein [Mycobacterium canettii CIPT 140010059]
Length=138

 Score = 58.2 bits (139),  Expect = 4e-07, Method: Compositional matrix adjust.
 Identities = 46/126 (37%), Positives = 68/126 (54%), Gaps = 8/126 (6%)

Query  1    MTT-WILDKSA----HVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTS  55
            MTT ++LDKSA    H+  V     P  ++   LA C I +LE+  SARS  D+ +  T 
Sbjct  1    MTTRYLLDKSAAYRAHLPAVRHRLEPL-MERGLLARCGITDLEFGVSARSREDHRTLGTY  59

Query  56   LR-AYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDY  114
             R A + +  P  ++DR   +Q  L   +G      +PDL IA  A HH   V+H+D+D+
Sbjct  60   RRDALEYVNTPDTVWDRAWEIQEALTD-KGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDF  118

Query  115  KRIAVV  120
            +RIA +
Sbjct  119  ERIAAI  124


>gi|290958509|ref|YP_003489691.1| hypothetical protein SCAB_40681 [Streptomyces scabiei 87.22]
 gi|260648035|emb|CBG71143.1| conserved hypothetical protein [Streptomyces scabiei 87.22]
Length=139

 Score = 57.8 bits (138),  Expect = 6e-07, Method: Compositional matrix adjust.
 Identities = 46/132 (35%), Positives = 63/132 (48%), Gaps = 13/132 (9%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            +++DKSA  R    +       L +   LA+C   E E ++SAR +++     T L A+ 
Sbjct  5    YLIDKSALARWTKPSVKEVLKPLHERYLLAVCQPTEFEMIHSARDSSEATRISTWLHAFD  64

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA--  118
             LR   D F R   +QR  A + G      LPDL IA TA  +R  VLH+D D+  IA  
Sbjct  65   YLRTDDDTFTRALEIQRH-ALNAGFHRALSLPDLLIAATAELNRRTVLHYDGDFDMIASL  123

Query  119  -------VVRPG  123
                   VV PG
Sbjct  124  TGQPTEWVVPPG  135


>gi|239988547|ref|ZP_04709211.1| hypothetical protein SrosN1_14659 [Streptomyces roseosporus NRRL 
11379]
 gi|291445528|ref|ZP_06584918.1| PilT protein domain-containing protein [Streptomyces roseosporus 
NRRL 15998]
 gi|291348475|gb|EFE75379.1| PilT protein domain-containing protein [Streptomyces roseosporus 
NRRL 15998]
Length=135

 Score = 57.0 bits (136),  Expect = 9e-07, Method: Compositional matrix adjust.
 Identities = 36/91 (40%), Positives = 48/91 (53%), Gaps = 3/91 (3%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            +A+CD+ ELE LYSARS  D +  +  L  Y     P  +F R R +Q  L       HR
Sbjct  34   VALCDLTELELLYSARSTEDREKVRERLALYTWCPMPDGVFRRARTVQDQLTAKGE--HR  91

Query  89   TPLP-DLFIAETALHHRAGVLHHDRDYKRIA  118
               P DL +A TA      +LH+DRD++ IA
Sbjct  92   NAGPVDLLLAATAEQSGLTLLHYDRDFETIA  122


>gi|343479040|gb|AEM44209.1| hypothetical protein [uncultured bacterium]
Length=139

 Score = 56.6 bits (135),  Expect = 1e-06, Method: Compositional matrix adjust.
 Identities = 46/132 (35%), Positives = 62/132 (47%), Gaps = 13/132 (9%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            +++DKSA  R    +       L +   LA+C   E E ++SAR  ++     T L A+ 
Sbjct  5    YLIDKSALARWTKPSVKEVLKPLHERYLLAVCQPTEFEMIHSARDGSEATRISTWLHAFD  64

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA--  118
             LR   D F R   +QR  A + G      LPDL IA TA  +R  VLH+D D+  IA  
Sbjct  65   YLRTDDDTFIRALEIQRH-ALNAGFHRALSLPDLLIAATAELNRRTVLHYDGDFDMIASL  123

Query  119  -------VVRPG  123
                   VV PG
Sbjct  124  TGQPTEWVVPPG  135


>gi|297154824|gb|ADI04536.1| hypothetical protein SBI_01415 [Streptomyces bingchenggensis 
BCW-1]
Length=139

 Score = 55.8 bits (133),  Expect = 2e-06, Method: Compositional matrix adjust.
 Identities = 33/92 (36%), Positives = 48/92 (53%), Gaps = 1/92 (1%)

Query  29   LAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHR  88
            LA+C   E+E +YSAR+  D       L  +  L    +++DR + +QR  A  +G    
Sbjct  33   LAVCGPVEIEVMYSARNENDAKRLHWFLAGFDYLPMTDEVWDRAKDVQRQ-AIAKGNHRA  91

Query  89   TPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
              +PDL IA  A  H   VLH+D+DY  IA +
Sbjct  92   LSMPDLLIAAAAERHVVTVLHYDQDYDMIAAI  123


>gi|308378090|ref|ZP_07668665.1| putative type I restriction-modification system, M subunit [Mycobacterium 
tuberculosis SUMu009]
 gi|308353571|gb|EFP42422.1| putative type I restriction-modification system, M subunit [Mycobacterium 
tuberculosis SUMu009]
Length=718

 Score = 55.8 bits (133),  Expect = 2e-06, Method: Compositional matrix adjust.
 Identities = 45/126 (36%), Positives = 67/126 (54%), Gaps = 8/126 (6%)

Query  1    MTT-WILDKSA----HVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTS  55
            MTT ++LDKSA    H+  V     P  ++   LA C I +LE+  SARS  D+ +  T 
Sbjct  11   MTTRYLLDKSAAYRAHLPAVRHRLEPL-MERGLLARCGITDLEFGVSARSREDHRTLGTY  69

Query  56   LR-AYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDY  114
             R A + +  P  ++ R   +Q  L   +G      +PDL IA  A HH   V+H+D+D+
Sbjct  70   RRDALEYVNTPDTVWVRAWEIQEALTD-KGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDF  128

Query  115  KRIAVV  120
            +RIA +
Sbjct  129  ERIAAI  134


>gi|302544584|ref|ZP_07296926.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
hygroscopicus ATCC 53653]
 gi|302462202|gb|EFL25295.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
himastatinicus ATCC 53653]
Length=138

 Score = 55.1 bits (131),  Expect = 4e-06, Method: Compositional matrix adjust.
 Identities = 44/123 (36%), Positives = 61/123 (50%), Gaps = 10/123 (8%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTDL----AICDIG--ELEWLYSARSATDYDSQQTSLR  57
            +++DKSA  R    A P     L  L     +C  G  E+E LYSAR+A + D     L 
Sbjct  5    YLIDKSALAR---SARPAVRETLNPLHERGLLCVTGAVEVEILYSARNANEADRLGRWLT  61

Query  58   AYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRI  117
             +  L  P +++D    +QR  A  +G      + DL IA TA  H A VLH+D DY +I
Sbjct  62   GFDYLPCPDEVWDAALDIQRQ-AIAKGNHRAFSMADLLIAATAQRHGATVLHYDGDYDQI  120

Query  118  AVV  120
            A +
Sbjct  121  AAI  123


>gi|15609894|ref|NP_217273.1| hypothetical protein Rv2757c [Mycobacterium tuberculosis H37Rv]
 gi|15842295|ref|NP_337332.1| hypothetical protein MT2827 [Mycobacterium tuberculosis CDC1551]
 gi|31793931|ref|NP_856424.1| hypothetical protein Mb2778c [Mycobacterium bovis AF2122/97]
 77 more sequence titles
 Length=138

 Score = 54.7 bits (130),  Expect = 4e-06, Method: Compositional matrix adjust.
 Identities = 45/126 (36%), Positives = 67/126 (54%), Gaps = 8/126 (6%)

Query  1    MTT-WILDKSA----HVRLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTS  55
            MTT ++LDKSA    H+  V     P  ++   LA C I +LE+  SARS  D+ +  T 
Sbjct  1    MTTRYLLDKSAAYRAHLPAVRHRLEPL-MERGLLARCGITDLEFGVSARSREDHRTLGTY  59

Query  56   LR-AYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDY  114
             R A + +  P  ++ R   +Q  L   +G      +PDL IA  A HH   V+H+D+D+
Sbjct  60   RRDALEYVNTPDTVWVRAWEIQEALTD-KGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDF  118

Query  115  KRIAVV  120
            +RIA +
Sbjct  119  ERIAAI  124


>gi|328882585|emb|CCA55824.1| hypothetical protein SVEN_2538 [Streptomyces venezuelae ATCC 
10712]
Length=138

 Score = 53.9 bits (128),  Expect = 8e-06, Method: Compositional matrix adjust.
 Identities = 41/127 (33%), Positives = 62/127 (49%), Gaps = 10/127 (7%)

Query  1    MTTWILDKSAHVRLVAGATPPAG------IDLTDLAICDIGELEWLYSARSATDYDSQQT  54
            M T+++D SA+V L  G  P A       I+   + +C+    E L+SA +A D ++ + 
Sbjct  1    MITYLVDTSAYVHL--GTDPAAQRRWDAEIETGAIGMCEATRTELLFSAVNADDREAIEE  58

Query  55   SLRA-YQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRD  113
             L A +  +R P D +  V   Q  L   +G      + DL I  TA+HH   VLH D D
Sbjct  59   DLAAMFAPVRVPKDAWRWVESAQYKLTQ-KGQHRAAGVIDLLICATAVHHGLTVLHRDND  117

Query  114  YKRIAVV  120
            +  +A V
Sbjct  118  FATVARV  124


>gi|284045212|ref|YP_003395552.1| PilT protein domain protein [Conexibacter woesei DSM 14684]
 gi|283949433|gb|ADB52177.1| PilT protein domain protein [Conexibacter woesei DSM 14684]
Length=148

 Score = 53.1 bits (126),  Expect = 1e-05, Method: Compositional matrix adjust.
 Identities = 35/119 (30%), Positives = 57/119 (48%), Gaps = 3/119 (2%)

Query  5    ILDKSAHVRLVAGATPPA---GIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAYQI  61
            I D SA +R  +G         +    +  C + +LE  ++AR A   ++ +   RA++ 
Sbjct  15   IADTSARLRARSGIVVAQWQRAVSARQITTCPVVKLELFHTARDANAVEAIEVEERAFRS  74

Query  62   LRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
            +     + +      R+LA   G +HR  LPD+ IA  A    A VLH+DR + R+A V
Sbjct  75   IPITRSVQNAAIGAVRELARRGGGYHRVSLPDVLIAAAAQDVGADVLHYDRHFDRLAEV  133


>gi|284991226|ref|YP_003409780.1| PilT protein domain-containing protein [Geodermatophilus obscurus 
DSM 43160]
 gi|284064471|gb|ADB75409.1| PilT protein domain protein [Geodermatophilus obscurus DSM 43160]
Length=141

 Score = 52.8 bits (125),  Expect = 2e-05, Method: Compositional matrix adjust.
 Identities = 43/121 (36%), Positives = 57/121 (48%), Gaps = 5/121 (4%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLR-AY  59
            ++LD SA  R+ A       + L     LA C   +LE LYSARS  +Y   +   R AY
Sbjct  7    YLLDTSAAARVPAPQVADRVVPLLSAGLLATCAALDLEALYSARSPREYREVRADRRLAY  66

Query  60   QILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAV  119
            + L      + R   +Q  LA   G W    L DL I+  A  HR  VLH+D D+  +A 
Sbjct  67   EYLPTEDGDWQRALQVQAALADA-GRWRGVGLADLVISAVAERHRVTVLHYDGDFDGVAA  125

Query  120  V  120
            V
Sbjct  126  V  126


>gi|302557955|ref|ZP_07310297.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
griseoflavus Tu4000]
 gi|302475573|gb|EFL38666.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
griseoflavus Tu4000]
Length=136

 Score = 52.0 bits (123),  Expect = 3e-05, Method: Compositional matrix adjust.
 Identities = 41/122 (34%), Positives = 60/122 (50%), Gaps = 12/122 (9%)

Query  4    WILDKSAHVR----LVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRAY  59
            +++DKSA  R     V G   P  I    LA+    E+E LYSAR+  +    +  L  +
Sbjct  3    YLIDKSALARRAKPAVRGVLDPL-IQRGLLAVTGAVEMEILYSARNPAEAGKLRYWLAGF  61

Query  60   QILRAPSDIFDRVRHLQRD---LAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKR  116
              L  P + +DR + +Q       +HR +     + DL IA TA  H   VLH+D DY++
Sbjct  62   DYLPCPDECWDRAKDVQAQATRTGNHRAL----SMADLLIAATAERHGVRVLHYDEDYEQ  117

Query  117  IA  118
            IA
Sbjct  118  IA  119


>gi|302534504|ref|ZP_07286846.1| predicted protein [Streptomyces sp. C]
 gi|302443399|gb|EFL15215.1| predicted protein [Streptomyces sp. C]
Length=140

 Score = 49.3 bits (116),  Expect = 2e-04, Method: Compositional matrix adjust.
 Identities = 43/136 (32%), Positives = 66/136 (49%), Gaps = 17/136 (12%)

Query  3    TWILDKSAHVRLVAGATPPAG----IDLTDLAICDIGELEWLYSARSATDYDSQQTSL-R  57
            T+++D SA VR++            +    + IC++ ELE L+SA+S  D   ++  L  
Sbjct  5    TYLIDTSAVVRVLTNEDVRKAWRDHLAEGVIGICEVTELEILFSAKSLADRLEKEALLGE  64

Query  58   AYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLP-DLFIAETALHHRAGVLHHDRDYKR  116
             +     P  ++ R R +QR L   RG  HR+  P DL +A TA      +LH+D+D+  
Sbjct  65   LFNWTPVPESVYVRARAVQR-LLTGRGE-HRSAGPVDLLVAATAELTGLTLLHYDKDFDA  122

Query  117  IA---------VVRPG  123
            IA         V RPG
Sbjct  123  IARATGQPTRWVARPG  138


>gi|315446124|ref|YP_004079003.1| nucleic acid-binding protein, contains PIN domain [Mycobacterium 
sp. Spyr1]
 gi|315264427|gb|ADU01169.1| predicted nucleic acid-binding protein, contains PIN domain [Mycobacterium 
sp. Spyr1]
Length=137

 Score = 48.5 bits (114),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 43/121 (36%), Positives = 58/121 (48%), Gaps = 8/121 (6%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTS--LRA  58
            W++DKSA+ RL         ++  D   + I  +  LE  YS R+A    S+  S  L  
Sbjct  6    WLIDKSAYTRLAVSPDVELWMERIDRGLVRISTVTRLEIGYSFRTAAQARSEVASPPLTL  65

Query  59   YQILRAPSDIFDRVRHLQRDLAHHRGMWHRTP-LPDLFIAETALHHRAGVLHHDRDYKRI  117
              I      + DR R +Q  LA  RGM HR P +PDL +A TA      VLH  +D+  I
Sbjct  66   MPIEYMTPTVEDRAREIQLTLAD-RGM-HRAPSIPDLLVAATAEQAGLTVLHLHKDFDLI  123

Query  118  A  118
            A
Sbjct  124  A  124


>gi|292491388|ref|YP_003526827.1| PilT protein domain protein [Nitrosococcus halophilus Nc4]
 gi|291579983|gb|ADE14440.1| PilT protein domain protein [Nitrosococcus halophilus Nc4]
Length=133

 Score = 48.5 bits (114),  Expect = 3e-04, Method: Compositional matrix adjust.
 Identities = 33/91 (37%), Positives = 46/91 (51%), Gaps = 2/91 (2%)

Query  28   DLAICDIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWH  87
            DLA+C +   E L   R    +   QT L    +L     +F +   + R L   +GM  
Sbjct  33   DLALCGVILTEILQGIRDDQTFSRTQTRLEPLLLLPMTQSVFIQAAIIYRGL-RAKGMTI  91

Query  88   RTPLPDLFIAETALHHRAGVLHHDRDYKRIA  118
            R P+ D  IA TAL H A +LH+DRD++ IA
Sbjct  92   RKPV-DCMIAATALEHGAWLLHNDRDFEAIA  121


>gi|145225766|ref|YP_001136444.1| PilT domain-containing protein [Mycobacterium gilvum PYR-GCK]
 gi|145218252|gb|ABP47656.1| PilT protein domain protein [Mycobacterium gilvum PYR-GCK]
Length=137

 Score = 48.1 bits (113),  Expect = 4e-04, Method: Compositional matrix adjust.
 Identities = 43/121 (36%), Positives = 58/121 (48%), Gaps = 8/121 (6%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTS--LRA  58
            W++DKSA+ RL         ++  D   + I  +  LE  YS R+A    S+  S  L  
Sbjct  6    WLIDKSAYTRLAVSPDVELWMERIDRGLVRISTVTRLEIGYSFRTAEQARSEVASPPLTL  65

Query  59   YQILRAPSDIFDRVRHLQRDLAHHRGMWHRTP-LPDLFIAETALHHRAGVLHHDRDYKRI  117
              I      + DR R +Q  LA  RGM HR P +PDL +A TA      VLH  +D+  I
Sbjct  66   MPIEYMTPTVEDRAREVQLTLAD-RGM-HRAPSIPDLLVAATAEQAGLTVLHLHKDFDLI  123

Query  118  A  118
            A
Sbjct  124  A  124


>gi|336119997|ref|YP_004574775.1| hypothetical protein MLP_43580 [Microlunatus phosphovorus NM-1]
 gi|334687787|dbj|BAK37372.1| hypothetical protein MLP_43580 [Microlunatus phosphovorus NM-1]
Length=139

 Score = 47.0 bits (110),  Expect = 0.001, Method: Compositional matrix adjust.
 Identities = 46/128 (36%), Positives = 61/128 (48%), Gaps = 10/128 (7%)

Query  1    MTTWILDKSAHV-----RLVAGATPPAGIDLTDLAICDIGELEWLYSARSATDYDS--QQ  53
            +T+W+LDKSA V     ++V        ID   + I  I  LE  YSAR+  D     ++
Sbjct  3    VTSWLLDKSAFVGLQLDQVVDAEVWKTRIDRGLVRISPITRLELGYSARTGVDGREGFRR  62

Query  54   TSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTP-LPDLFIAETALHHRAGVLHHDR  112
              +    + R    I DR   +Q  LA  RG  HR P +PDL IA TA      VL  D+
Sbjct  63   PPVSLMPVERITPAIEDRAEEVQMLLAD-RGQ-HRAPSIPDLLIAATAEKAGLTVLAVDK  120

Query  113  DYKRIAVV  120
            D+  IA V
Sbjct  121  DFDLIAEV  128


>gi|254388989|ref|ZP_05004220.1| conserved membrane protein [Streptomyces clavuligerus ATCC 27064]
 gi|294814925|ref|ZP_06773568.1| toxin [Streptomyces clavuligerus ATCC 27064]
 gi|326443296|ref|ZP_08218030.1| PilT protein domain-containing protein [Streptomyces clavuligerus 
ATCC 27064]
 gi|197702707|gb|EDY48519.1| conserved membrane protein [Streptomyces clavuligerus ATCC 27064]
 gi|294327524|gb|EFG09167.1| toxin [Streptomyces clavuligerus ATCC 27064]
Length=139

 Score = 46.2 bits (108),  Expect = 0.002, Method: Compositional matrix adjust.
 Identities = 31/99 (32%), Positives = 47/99 (48%), Gaps = 1/99 (1%)

Query  34   IGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPD  93
            I +LE L+SAR+A DY+      +A++      +I  R   +Q      +G      +PD
Sbjct  39   IIDLELLFSARNADDYERMLGRRQAFEWFPTTDEIVARAIEVQ-GFCARKGNHRALSIPD  97

Query  94   LFIAETALHHRAGVLHHDRDYKRIAVVRPGFQACELSRG  132
            L +A TA  H   +LH+D D+  IA V        + RG
Sbjct  98   LLVAATAERHGLTLLHYDGDFDLIAEVTGQLTEWIVPRG  136


>gi|302552928|ref|ZP_07305270.1| conserved hypothetical protein [Streptomyces viridochromogenes 
DSM 40736]
 gi|302470546|gb|EFL33639.1| conserved hypothetical protein [Streptomyces viridochromogenes 
DSM 40736]
Length=136

 Score = 45.4 bits (106),  Expect = 0.002, Method: Compositional matrix adjust.
 Identities = 39/120 (33%), Positives = 53/120 (45%), Gaps = 6/120 (5%)

Query  4    WILDKSAHVRLVAGATPPAG----IDLTDLAICDIGELEWLYSARSATDYDS-QQTSLRA  58
            ++LD S  VRL+            ID   +A C +   E+LYSAR+  +YD   +     
Sbjct  3    YLLDTSGLVRLLRDPKLQTAWYDAIDAGAIASCYVQRAEFLYSARNGREYDEIAEMFTDI  62

Query  59   YQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA  118
            Y     P +    +  +Q  +A   G        DL IA TA HH   VLH D DY+ IA
Sbjct  63   YPDAAVPKNAGRWISSVQHRMAQ-AGEHRSASAVDLVIAATAAHHGLAVLHDDADYRAIA  121


>gi|289748705|ref|ZP_06508083.1| LOW QUALITY PROTEIN: conserved membrane protein [Mycobacterium 
tuberculosis T92]
 gi|289689292|gb|EFD56721.1| LOW QUALITY PROTEIN: conserved membrane protein [Mycobacterium 
tuberculosis T92]
Length=126

 Score = 44.7 bits (104),  Expect = 0.005, Method: Compositional matrix adjust.
 Identities = 34/107 (32%), Positives = 50/107 (47%), Gaps = 8/107 (7%)

Query  20   PPAGIDLTDLAIC------DIGELEWLYSARSATDYDSQQTSLRAYQILRAPSDIFDRVR  73
            PP G  +  LA         I +LE  YSAR+ T++     +L A+ ++ + +    R  
Sbjct  7    PPCGGAVEPLAEAGAVARTQITDLEVGYSARNETEWQRLMVALSAFDLIESTASHHRRAL  66

Query  74   HLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
             +QR LA       +  +PDL IA     H   VLH+D D+  IA V
Sbjct  67   GIQRLLAARSQRGRK--IPDLLIAAAGEEHGLVVLHYDADFDLIAAV  111


>gi|302559520|ref|ZP_07311862.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
griseoflavus Tu4000]
 gi|302477138|gb|EFL40231.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
griseoflavus Tu4000]
Length=127

 Score = 44.7 bits (104),  Expect = 0.005, Method: Compositional matrix adjust.
 Identities = 34/98 (35%), Positives = 48/98 (49%), Gaps = 4/98 (4%)

Query  23   GIDLTDLAICDIGELEWLYSARSATDYDS-QQTSLRAYQILRAPSDIFDRVRHLQRDLAH  81
             ID   +A C +   E+L+SAR+  +YD   +     Y  +  P +    +  +Q  +A 
Sbjct  17   AIDAGAIASCYVQRAEFLHSARNGREYDEITEMFTDLYPDVSVPKNAGRWIGAMQHRMA-  75

Query  82   HRGMWHRTPLP-DLFIAETALHHRAGVLHHDRDYKRIA  118
             R   HR+    DL IA TA HH   VLH D DY+ IA
Sbjct  76   -RAGEHRSASAVDLLIAATAAHHGLAVLHDDADYRAIA  112


>gi|29832237|ref|NP_826871.1| hypothetical protein SAV_5694 [Streptomyces avermitilis MA-4680]
 gi|29609355|dbj|BAC73406.1| hypothetical protein [Streptomyces avermitilis MA-4680]
Length=135

 Score = 44.3 bits (103),  Expect = 0.007, Method: Compositional matrix adjust.
 Identities = 42/130 (33%), Positives = 56/130 (44%), Gaps = 6/130 (4%)

Query  1    MTTWILDKSA--HVRLVAGATPP--AGIDLTDLAICDIGELEWLYSARSATDYDSQQTSL  56
            M T++LD SA  H+    GA  P    I      +C+    E+LYSA S T  D     L
Sbjct  1    MITYLLDTSALWHLFRTPGALAPWEGHIAAGVFHLCEPTRAEFLYSATSPTHRDELAEEL  60

Query  57   RAYQILR-APSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYK  115
             A  +L   P + +  V   Q  L   +G        DL +  TA+HH   VLH D D+ 
Sbjct  61   DALCLLSPVPKNAWRWVDTAQYKLTQ-QGQHRAAGAIDLLVCATAVHHGHTVLHVDNDFA  119

Query  116  RIAVVRPGFQ  125
             +A V    Q
Sbjct  120  TVAGVLKELQ  129


>gi|289572808|ref|ZP_06453035.1| toxin [Mycobacterium tuberculosis K85]
 gi|289537239|gb|EFD41817.1| toxin [Mycobacterium tuberculosis K85]
Length=547

 Score = 44.3 bits (103),  Expect = 0.007, Method: Compositional matrix adjust.
 Identities = 40/128 (32%), Positives = 60/128 (47%), Gaps = 7/128 (5%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            ++LD S   RL   A   A   L +   +A   I +LE  YSAR+ T++     +L A+ 
Sbjct  415  YLLDTSVIKRLSRPAVRRAVEPLAEAGAVARTQITDLEVGYSARNETEWQRLMVALSAFD  474

Query  61   ILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIAVV  120
            ++ + +    R   +QR LA       +  +PDL IA     H   VLH+D D+  IA V
Sbjct  475  LIESTASHHRRALGIQRLLAARSQRGRK--IPDLLIAAAGEEHGLVVLHYDADFDLIAAV  532

Query  121  RPGFQACE  128
                Q C+
Sbjct  533  T--GQPCQ  538


>gi|167968774|ref|ZP_02551051.1| hypothetical protein MtubH3_12355 [Mycobacterium tuberculosis 
H37Ra]
 gi|253797151|ref|YP_003030152.1| toxin [Mycobacterium tuberculosis KZN 1435]
 gi|308231499|ref|ZP_07412656.2| toxin [Mycobacterium tuberculosis SUMu001]
 27 more sequence titles
 Length=137

 Score = 43.9 bits (102),  Expect = 0.008, Method: Compositional matrix adjust.
 Identities = 40/122 (33%), Positives = 58/122 (48%), Gaps = 9/122 (7%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            ++LD S   RL   A   A   L +   +A   I +LE  YSAR+ T++     +L A+ 
Sbjct  5    YLLDTSVIKRLSRPAVRRAVEPLAEAGAVARTQITDLEVGYSARNETEWQRLMVALSAFD  64

Query  61   ILRAPSDIFDRVRHLQRDLA--HHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA  118
            ++ + +    R   +QR LA    RG      +PDL IA     H   VLH+D D+  IA
Sbjct  65   LIESTASHHRRALGIQRLLAARSQRG----RKIPDLLIAAAGEEHGLVVLHYDADFDLIA  120

Query  119  VV  120
             V
Sbjct  121  AV  122


>gi|15607370|ref|NP_214743.1| hypothetical protein Rv0229c [Mycobacterium tuberculosis H37Rv]
 gi|15839609|ref|NP_334646.1| hypothetical protein MT0239 [Mycobacterium tuberculosis CDC1551]
 gi|31791406|ref|NP_853899.1| hypothetical protein Mb0234c [Mycobacterium bovis AF2122/97]
 42 more sequence titles
 Length=226

 Score = 43.9 bits (102),  Expect = 0.008, Method: Compositional matrix adjust.
 Identities = 40/122 (33%), Positives = 58/122 (48%), Gaps = 9/122 (7%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            ++LD S   RL   A   A   L +   +A   I +LE  YSAR+ T++     +L A+ 
Sbjct  94   YLLDTSVIKRLSRPAVRRAVEPLAEAGAVARTQITDLEVGYSARNETEWQRLMVALSAFD  153

Query  61   ILRAPSDIFDRVRHLQRDLA--HHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA  118
            ++ + +    R   +QR LA    RG      +PDL IA     H   VLH+D D+  IA
Sbjct  154  LIESTASHHRRALGIQRLLAARSQRG----RKIPDLLIAAAGEEHGLVVLHYDADFDLIA  209

Query  119  VV  120
             V
Sbjct  210  AV  211


>gi|239990082|ref|ZP_04710746.1| hypothetical protein SrosN1_22440 [Streptomyces roseosporus NRRL 
11379]
 gi|291447096|ref|ZP_06586486.1| conserved hypothetical protein [Streptomyces roseosporus NRRL 
15998]
 gi|291350043|gb|EFE76947.1| conserved hypothetical protein [Streptomyces roseosporus NRRL 
15998]
Length=136

 Score = 43.1 bits (100),  Expect = 0.014, Method: Compositional matrix adjust.
 Identities = 40/125 (32%), Positives = 57/125 (46%), Gaps = 8/125 (6%)

Query  4    WILDKSAHVRLVAGATPPAG----IDLTDLAICDIGELEWLYSARSATDYDS-QQTSLRA  58
            ++LD S  VRL++     A     I+   +A C     E+LY AR+A +YD   +     
Sbjct  3    YLLDTSGLVRLLSDPALQAAWSDAIEAGAIASCYPQRAEFLYGARNAREYDEIVEMFTDL  62

Query  59   YQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLP-DLFIAETALHHRAGVLHHDRDYKRI  117
            Y  +  P      +  +Q  +A  R   HR+    DL IA TA HH   VLH   DY+ +
Sbjct  63   YPDVSVPKSAGRWITSVQHRMA--RAGQHRSASAVDLIIAATAAHHGLTVLHDGFDYRTV  120

Query  118  AVVRP  122
            A   P
Sbjct  121  ARYAP  125


>gi|295840079|ref|ZP_06827012.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
sp. SPB74]
 gi|197697029|gb|EDY43962.1| PIN family toxin-antitoxin system, toxin component [Streptomyces 
sp. SPB74]
Length=139

 Score = 43.1 bits (100),  Expect = 0.015, Method: Compositional matrix adjust.
 Identities = 44/136 (33%), Positives = 61/136 (45%), Gaps = 10/136 (7%)

Query  1    MTTWILDKSAHVRLVAGA-TPPAGIDLT---DLAICDIGELEWLYSARSATDYDS--QQT  54
            M  +++D SA VR        PA  D     ++ I    E E  YSA+ A D D   Q+ 
Sbjct  1    MINYLIDTSAVVRFFKSPDLFPAWKDCIVRGEVGIIPPIEFEICYSAQKARDRDELLQKL  60

Query  55   SLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTPLP-DLFIAETALHHRAGVLHHDRD  113
             L    +   P+  +D  R +Q  L  H    HR+  P DL +A TA      VLH D+D
Sbjct  61   GLLFSAVTPTPA-AYDAGRDMQEALTKHGA--HRSCGPVDLLLAGTAHVESLTVLHVDKD  117

Query  114  YKRIAVVRPGFQACEL  129
            Y  +A + P F+   L
Sbjct  118  YVTLARLWPSFRQVRL  133


>gi|289445761|ref|ZP_06435505.1| toxin [Mycobacterium tuberculosis CPHL_A]
 gi|289418719|gb|EFD15920.1| toxin [Mycobacterium tuberculosis CPHL_A]
Length=226

 Score = 42.0 bits (97),  Expect = 0.029, Method: Compositional matrix adjust.
 Identities = 39/122 (32%), Positives = 57/122 (47%), Gaps = 9/122 (7%)

Query  4    WILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQTSLRAYQ  60
            ++LD S   RL   A   A   L +   +A   I +LE  Y AR+ T++     +L A+ 
Sbjct  94   YLLDTSVIKRLSRPAVRRAVEPLAEAGAVARTQITDLEVGYPARNETEWQRLMVALSAFD  153

Query  61   ILRAPSDIFDRVRHLQRDLA--HHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRIA  118
            ++ + +    R   +QR LA    RG      +PDL IA     H   VLH+D D+  IA
Sbjct  154  LIESTASHHRRALGIQRLLAARSQRG----RKIPDLLIAAAGEEHGLVVLHYDADFDLIA  209

Query  119  VV  120
             V
Sbjct  210  AV  211


>gi|315441643|ref|YP_004074520.1| nucleic acid-binding protein, contains PIN domain [Mycobacterium 
sp. Spyr1]
 gi|315265298|gb|ADU02039.1| predicted nucleic acid-binding protein, contains PIN domain [Mycobacterium 
sp. Spyr1]
Length=134

 Score = 42.0 bits (97),  Expect = 0.035, Method: Compositional matrix adjust.
 Identities = 40/128 (32%), Positives = 63/128 (50%), Gaps = 12/128 (9%)

Query  1    MTTWILDKSAHVRLVAGATPPAGIDLTD---LAICDIGELEWLYSARSATDYDSQQ----  53
            MT W++DKSA+ +LVA     A ++  +   + +  +  L+  YS R+ +   S+     
Sbjct  1    MTNWLIDKSAYTQLVASPDAQAWVERIERGLVRMSTVTRLQIGYSFRNGSQARSESGAPP  60

Query  54   TSLRAYQILRAPSDIFDRVRHLQRDLAHHRGMWHRTP-LPDLFIAETALHHRAGVLHHDR  112
             +L   + L   ++  DR   +Q  LA  RG+ HR P +PDL +A  A      VL  D 
Sbjct  61   LALMPLEYLTPAAE--DRAVGVQLQLA-DRGL-HRAPAIPDLLVAAVAEMAGLTVLALDT  116

Query  113  DYKRIAVV  120
            D+  IA V
Sbjct  117  DFDLIAQV  124


>gi|297199892|ref|ZP_06917289.1| conserved hypothetical protein [Streptomyces sviceus ATCC 29083]
 gi|197710357|gb|EDY54391.1| conserved hypothetical protein [Streptomyces sviceus ATCC 29083]
Length=139

 Score = 41.6 bits (96),  Expect = 0.043, Method: Compositional matrix adjust.
 Identities = 37/123 (31%), Positives = 58/123 (48%), Gaps = 5/123 (4%)

Query  2    TTWILDKSAHVRLVAGATPP---AGIDLTDLAICDIGELEWLYSARSATDYDSQQTSLRA  58
            T +++D SA VR++     P     ++   ++ C + E+E+LYSAR+A D       L A
Sbjct  4    TAYLIDTSALVRILKHPARPRWEKPLEEGLISRCPMTEVEFLYSARNAEDRSELVQDLDA  63

Query  59   YQILRAPSD-IFDRVRHLQRDLAHHRGMWHRTPLPDLFIAETALHHRAGVLHHDRDYKRI  117
                    D    R   +QR+L   +G        DL +A TA      +LH+D D++ I
Sbjct  64   LFGWTPLDDRAVSRAWDVQRELTE-KGQHRSAGAVDLLVAATAELQGLTMLHYDNDFETI  122

Query  118  AVV  120
            A V
Sbjct  123  ASV  125



Lambda     K      H
   0.325    0.138    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 130457467840


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40