BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2625c Length=393 Score E Sequences producing significant alignments: (Bits) Value gi|15609762|ref|NP_217141.1| hypothetical protein Rv2625c [Mycob... 760 0.0 gi|340627645|ref|YP_004746097.1| hypothetical protein MCAN_26701... 758 0.0 gi|118618612|ref|YP_906944.1| hypothetical protein MUL_3269 [Myc... 586 2e-165 gi|183982089|ref|YP_001850380.1| hypothetical protein MMAR_2075 ... 584 8e-165 gi|240170639|ref|ZP_04749298.1| hypothetical protein MkanA1_1509... 578 4e-163 gi|296170900|ref|ZP_06852437.1| peptidase M50 [Mycobacterium par... 559 2e-157 gi|120402423|ref|YP_952252.1| peptidase M50 [Mycobacterium vanba... 348 7e-94 gi|330469516|ref|YP_004407259.1| peptidase M50 [Verrucosispora m... 296 4e-78 gi|302869201|ref|YP_003837838.1| peptidase M50 [Micromonospora a... 286 5e-75 gi|134098999|ref|YP_001104660.1| peptidase M50 [Saccharopolyspor... 284 1e-74 gi|315504322|ref|YP_004083209.1| peptidase m50 [Micromonospora s... 276 5e-72 gi|238060469|ref|ZP_04605178.1| peptidase M50 [Micromonospora sp... 267 3e-69 gi|159039184|ref|YP_001538437.1| peptidase M50 [Salinispora aren... 263 4e-68 gi|257055198|ref|YP_003133030.1| Zn-dependent protease [Saccharo... 261 2e-67 gi|145595913|ref|YP_001160210.1| peptidase M50 [Salinispora trop... 259 7e-67 gi|269124430|ref|YP_003297800.1| peptidase M50 [Thermomonospora ... 258 9e-67 gi|345016148|ref|YP_004818502.1| peptidase M50 [Streptomyces vio... 243 5e-62 gi|86743169|ref|YP_483569.1| peptidase M50 [Frankia sp. CcI3] >g... 237 2e-60 gi|284990848|ref|YP_003409402.1| peptidase M50 [Geodermatophilus... 236 5e-60 gi|333919806|ref|YP_004493387.1| peptidase M50 [Amycolicicoccus ... 231 2e-58 gi|119510923|ref|ZP_01630046.1| protease family protein [Nodular... 231 2e-58 gi|296270589|ref|YP_003653221.1| peptidase M50 [Thermobispora bi... 230 3e-58 gi|254380696|ref|ZP_04996062.1| peptidase M50 [Streptomyces sp. ... 228 1e-57 gi|297159306|gb|ADI09018.1| peptidase M50 [Streptomyces bingchen... 224 2e-56 gi|291006839|ref|ZP_06564812.1| peptidase M50 [Saccharopolyspora... 223 4e-56 gi|337769503|emb|CCB78216.1| Zn-dependent protease [Streptomyces... 220 3e-55 gi|134099062|ref|YP_001104723.1| peptidase M50 [Saccharopolyspor... 217 2e-54 gi|302544335|ref|ZP_07296677.1| putative membrane protein [Strep... 214 2e-53 gi|91202292|emb|CAJ75352.1| conserved hypothetical protein [Cand... 213 6e-53 gi|332702988|ref|ZP_08423076.1| peptidase M50 [Desulfovibrio afr... 201 1e-49 gi|269836755|ref|YP_003318983.1| CBS domain-containing protein [... 201 2e-49 gi|57234442|ref|YP_181501.1| protease family protein [Dehalococc... 201 2e-49 gi|300087970|ref|YP_003758492.1| peptidase M50 [Dehalogenimonas ... 200 3e-49 gi|270308082|ref|YP_003330140.1| protease [Dehalococcoides sp. V... 199 6e-49 gi|206889277|ref|YP_002248414.1| peptidase, M50 family protein [... 198 1e-48 gi|134099210|ref|YP_001104871.1| peptidase M50 [Saccharopolyspor... 197 2e-48 gi|116749915|ref|YP_846602.1| peptidase M50 [Syntrophobacter fum... 193 4e-47 gi|254467670|ref|ZP_05081078.1| peptidase, M50 family protein [R... 192 6e-47 gi|298528325|ref|ZP_07015729.1| peptidase M50 [Desulfonatronospi... 191 2e-46 gi|85860795|ref|YP_462997.1| M50 family membrane endopeptidase [... 189 7e-46 gi|225849662|ref|YP_002729896.1| zinc metalloprotease Sll0528 [P... 189 8e-46 gi|73748579|ref|YP_307818.1| M50 family metallopeptidase [Dehalo... 189 1e-45 gi|21227420|ref|NP_633342.1| hypothetical protein MM_1318 [Metha... 187 2e-45 gi|332710745|ref|ZP_08430686.1| Zn-dependent protease [Lyngbya m... 187 3e-45 gi|254410553|ref|ZP_05024332.1| peptidase, M50 family protein [M... 187 3e-45 gi|188586364|ref|YP_001917909.1| peptidase M50 [Natranaerobius t... 186 8e-45 gi|334120955|ref|ZP_08495031.1| peptidase M50 [Microcoleus vagin... 185 1e-44 gi|126654899|ref|ZP_01726433.1| hypothetical protein CY0110_1069... 184 3e-44 gi|67920031|ref|ZP_00513551.1| Peptidase M50 [Crocosphaera watso... 183 4e-44 gi|20088906|ref|NP_614981.1| hypothetical protein MA0007 [Methan... 182 1e-43 >gi|15609762|ref|NP_217141.1| hypothetical protein Rv2625c [Mycobacterium tuberculosis H37Rv] gi|15842165|ref|NP_337202.1| hypothetical protein MT2700 [Mycobacterium tuberculosis CDC1551] gi|31793811|ref|NP_856304.1| hypothetical protein Mb2658c [Mycobacterium bovis AF2122/97] 78 more sequence titles Length=393 Score = 760 bits (1962), Expect = 0.0, Method: Compositional matrix adjust. Identities = 393/393 (100%), Positives = 393/393 (100%), Gaps = 0/393 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL Sbjct 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS Sbjct 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 Query 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD Sbjct 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ Sbjct 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD Sbjct 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP Sbjct 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 Query 361 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG 393 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG Sbjct 361 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG 393 >gi|340627645|ref|YP_004746097.1| hypothetical protein MCAN_26701 [Mycobacterium canettii CIPT 140010059] gi|340005835|emb|CCC45001.1| putative conserved transmembrane alanine and leucine rich protein [Mycobacterium canettii CIPT 140010059] Length=393 Score = 758 bits (1956), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 0/393 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 MRDAIPLGRIAGF VNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL Sbjct 1 MRDAIPLGRIAGFAVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS Sbjct 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 Query 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD Sbjct 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ Sbjct 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD Sbjct 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 VAPSRRSTTSVGDIALPLHS+PTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP Sbjct 301 VAPSRRSTTSVGDIALPLHSLPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 Query 361 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG 393 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG Sbjct 361 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG 393 >gi|118618612|ref|YP_906944.1| hypothetical protein MUL_3269 [Mycobacterium ulcerans Agy99] gi|118570722|gb|ABL05473.1| conserved transmembrane alanine and leucine rich protein [Mycobacterium ulcerans Agy99] Length=392 Score = 586 bits (1511), Expect = 2e-165, Method: Compositional matrix adjust. Identities = 311/393 (80%), Positives = 341/393 (87%), Gaps = 1/393 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 M D IPLGRIAGF V VHWSVLVILWLFTWSLAT LP T GY AVVYW+ G GA++LL Sbjct 1 MSDEIPLGRIAGFAVKVHWSVLVILWLFTWSLATTLPETAKGYGAVVYWIAGGCGALVLL 60 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 ASLLAHELAHA+ ARRAGV V +VTLWLFGGVT LGGEAKTPKAAFRIAFAGPATSLALS Sbjct 61 ASLLAHELAHAIAARRAGVPVGNVTLWLFGGVTTLGGEAKTPKAAFRIAFAGPATSLALS 120 Query 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 A F A+A+ LA VRTP +V+SV WWLA VNL+LGLFNLLPGAPLDGGRLVRAYLWRRHGD Sbjct 121 AMFTAVAVALAMVRTPDLVVSVVWWLAAVNLMLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 VRAGIGAARAGRVVALVLI LGLAEFVAGGLVGGVWL FIGWFIFAAAREEETRISTQQ Sbjct 181 IVRAGIGAARAGRVVALVLIILGLAEFVAGGLVGGVWLVFIGWFIFAAAREEETRISTQQ 240 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 LF G+RVADAMTA PHTAPGWI+V++FI RYVLG+RHSAYPV +RDGSITGLV LRQLR+ Sbjct 241 LFTGLRVADAMTAHPHTAPGWIDVDEFIARYVLGDRHSAYPVTERDGSITGLVTLRQLRE 300 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 +AP RR +T+V +IALPLH VPTA PQEPLT LLERMAP G SRALV +G AVVGIV Sbjct 301 LAPERRGSTTVREIALPLHDVPTATPQEPLTTLLERMAPAGRGSRALVLDGGAVVGIVAA 360 Query 361 SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG 393 SD+ARLI+VYRLA P T ++ Q +++S+AG Sbjct 361 SDIARLINVYRLAGPGATADSADQH-EKYSNAG 392 >gi|183982089|ref|YP_001850380.1| hypothetical protein MMAR_2075 [Mycobacterium marinum M] gi|183175415|gb|ACC40525.1| conserved transmembrane alanine and leucine rich protein [Mycobacterium marinum M] Length=410 Score = 584 bits (1506), Expect = 8e-165, Method: Compositional matrix adjust. Identities = 309/391 (80%), Positives = 340/391 (87%), Gaps = 1/391 (0%) Query 3 DAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLLAS 62 D IPLGRIAGF V VHWSVLVILWLFTWSLAT LP T GY AVVYW+ G GA++LLAS Sbjct 21 DEIPLGRIAGFAVKVHWSVLVILWLFTWSLATTLPETAKGYGAVVYWIAGGCGALVLLAS 80 Query 63 LLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSAT 122 LLAHELAHA+ ARRAGV V +VTLWLFGGVT LGGEAKTPKAAFRIAFAGPATSLALSA Sbjct 81 LLAHELAHAIAARRAGVPVGNVTLWLFGGVTTLGGEAKTPKAAFRIAFAGPATSLALSAM 140 Query 123 FGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSV 182 F A+A+ LA VRTP +V+SV WWLA VNL+LGLFNLLPGAPLDGGRLVRAYLWRRHGD V Sbjct 141 FTAVAVALAMVRTPDLVVSVVWWLAAVNLMLGLFNLLPGAPLDGGRLVRAYLWRRHGDIV 200 Query 183 RAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLF 242 RAGIGAARAGRVVAL+LI LGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLF Sbjct 201 RAGIGAARAGRVVALILIILGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLF 260 Query 243 AGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVA 302 G+RVADAMTA PHTAPGWI+V++FI RYVLG+RHSAYPV +RDGSITGLV LRQLR++A Sbjct 261 TGLRVADAMTAHPHTAPGWIDVDEFIARYVLGDRHSAYPVTERDGSITGLVTLRQLRELA 320 Query 303 PSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSD 362 P RR +T+V +IALPLH VPTA PQEPLT LLERMAP G SRALV +G VVGIV SD Sbjct 321 PERRGSTTVREIALPLHDVPTATPQEPLTTLLERMAPAGRGSRALVLDGGGVVGIVAASD 380 Query 363 VARLIDVYRLAQPEPTFTTSPQDADRFSDAG 393 +ARLI+VYRLA P T ++ Q +++S+AG Sbjct 381 IARLINVYRLAGPGATADSADQH-EKYSNAG 410 >gi|240170639|ref|ZP_04749298.1| hypothetical protein MkanA1_15095 [Mycobacterium kansasii ATCC 12478] Length=385 Score = 578 bits (1491), Expect = 4e-163, Method: Compositional matrix adjust. Identities = 319/384 (84%), Positives = 342/384 (90%), Gaps = 3/384 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 M D IPLGRIAGF V VHWSVLVILWLFTWSLAT LPG V GY V YWL GAGGA +LL Sbjct 1 MHDEIPLGRIAGFSVKVHWSVLVILWLFTWSLATTLPGAVKGYAPVAYWLAGAGGAAVLL 60 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 ASLLAHELAHA+VARR GV VE+VTLWLFGGVT LGGEAKTPKAAFRIAFAGPATSLALS Sbjct 61 ASLLAHELAHAIVARRCGVPVENVTLWLFGGVTTLGGEAKTPKAAFRIAFAGPATSLALS 120 Query 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 ATFG LA+ LA +RTP IV+SVAWWLA VNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD Sbjct 121 ATFGTLAVALAVIRTPPIVVSVAWWLAGVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 VRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRIST+Q Sbjct 181 IVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTRQ 240 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 LF+GV VADAMT QPHTAPGWI VE+FIQRYVLG+RHSAYPVA++DGSI GLV LRQLR+ Sbjct 241 LFSGVTVADAMTPQPHTAPGWITVEEFIQRYVLGDRHSAYPVAEQDGSIMGLVTLRQLRE 300 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 + P+RR TTSV DIA+PL VPTA P+EPL+ALLE+MAP GPRSRALV + AVVGIVT Sbjct 301 LPPARRGTTSVRDIAVPLQEVPTAAPREPLSALLEQMAPAGPRSRALVVDAGAVVGIVTA 360 Query 361 SDVARLIDVYRLAQPEPTFTTSPQ 384 SD+ARL+DVYRLAQP P +PQ Sbjct 361 SDIARLVDVYRLAQPAP---ATPQ 381 >gi|296170900|ref|ZP_06852437.1| peptidase M50 [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894449|gb|EFG74193.1| peptidase M50 [Mycobacterium parascrofulaceum ATCC BAA-614] Length=386 Score = 559 bits (1441), Expect = 2e-157, Method: Compositional matrix adjust. Identities = 297/385 (78%), Positives = 330/385 (86%), Gaps = 0/385 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 MRDAIP+GRIAGF VNVHWSVLVILWLFTWSLA+ LPG+V GY YWL GA GA++LL Sbjct 1 MRDAIPIGRIAGFPVNVHWSVLVILWLFTWSLASTLPGSVKGYSHGAYWLAGACGALVLL 60 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 ASL+AHELAHAVVARRAGVSV SVTLWLFGGVT LGGEAKTPKAAFRIA AGPATSLAL+ Sbjct 61 ASLVAHELAHAVVARRAGVSVGSVTLWLFGGVTTLGGEAKTPKAAFRIAIAGPATSLALA 120 Query 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 A FG L L+ V IV+ VA WLA +NLLLGLFNLLPGAPLDGGR++RA+LWRRHGD Sbjct 121 AIFGGLVAALSTVGAAPIVVGVASWLAGINLLLGLFNLLPGAPLDGGRVLRAFLWRRHGD 180 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 SVRA IGAA AGRVVA +LI LGLAEF+ GG+VGGVWLAFIGWFIFAA+REEETRISTQQ Sbjct 181 SVRASIGAAHAGRVVAFILIGLGLAEFLLGGMVGGVWLAFIGWFIFAASREEETRISTQQ 240 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 +F+GVRV DAMTA+PHTAPGWI V+DF+QRYVLG+RHSAYPV D G++TGL+ LRQLRD Sbjct 241 MFSGVRVTDAMTARPHTAPGWITVDDFVQRYVLGDRHSAYPVVDPSGAVTGLITLRQLRD 300 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 VAP RR+TT+V ++A PLH VP+ PQEPLTALLERMAP GPRSRALV EG VVGIVTP Sbjct 301 VAPGRRATTTVAEVAQPLHEVPSGAPQEPLTALLERMAPAGPRSRALVFEGGQVVGIVTP 360 Query 361 SDVARLIDVYRLAQPEPTFTTSPQD 385 +DVARLI+VYRLA P S Q Sbjct 361 TDVARLIEVYRLAHPGDAKPASTQS 385 >gi|120402423|ref|YP_952252.1| peptidase M50 [Mycobacterium vanbaalenii PYR-1] gi|119955241|gb|ABM12246.1| peptidase M50 [Mycobacterium vanbaalenii PYR-1] Length=383 Score = 348 bits (894), Expect = 7e-94, Method: Compositional matrix adjust. Identities = 211/373 (57%), Positives = 259/373 (70%), Gaps = 1/373 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL 60 M + LGR+ G V VHWSV+VI+WLF WSLA+ LPG+ GYP VYW+ G GA + Sbjct 1 MEHGVALGRMRGLTVTVHWSVVVIVWLFAWSLASTLPGSAPGYPDAVYWVAGFCGAALFA 60 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 A LLAHELAHAVVARR+G+ V +TLWLFGGV L GEAKTP+ FR+A AGPA SLALS Sbjct 61 AGLLAHELAHAVVARRSGIPVPEITLWLFGGVARLAGEAKTPRDEFRMAAAGPALSLALS 120 Query 121 ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 A F A+A LAG + VA WLA N +L +FNLLPGAPLDGGR++RAYLW RHGD Sbjct 121 AVFAAVAAGLAGTGISPLATEVAAWLAAANAVLAVFNLLPGAPLDGGRILRAYLWHRHGD 180 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 VRA IGAARAGRVVA +LI LGL EF+ G L+GG WLAFIGWF+ AAR+E + + Sbjct 181 PVRAAIGAARAGRVVAYLLIGLGLVEFLLGSLIGGAWLAFIGWFLLTAARDENAAVRARA 240 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 AGVRVA MT P T P ++V+ FI ++LG+RHSAYPV DG+ TGLV L Q+R Sbjct 241 SLAGVRVAAVMTPNPRTVPESLSVQRFIDDHLLGDRHSAYPVTHPDGTCTGLVTLAQVRV 300 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP 360 V P R TT + DIA+P + + TA P EPL +++R+ +R +V +G+VT Sbjct 301 VPPVERDTTRLADIAIPRNRMATADPGEPLVEVVQRL-DRSTGNRIVVMAADRAIGVVTA 359 Query 361 SDVARLIDVYRLA 373 +DVAR+IDV LA Sbjct 360 ADVARMIDVRNLA 372 >gi|330469516|ref|YP_004407259.1| peptidase M50 [Verrucosispora maris AB-18-032] gi|328812487|gb|AEB46659.1| peptidase M50 [Verrucosispora maris AB-18-032] Length=379 Score = 296 bits (758), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 172/369 (47%), Positives = 226/369 (62%), Gaps = 3/369 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSL-ATMLPGTVGGYPAVVYWLLGAGGAVML 59 MR + LGRIAG V V+WSVLVI L W L A + P + G V Y G AV+ Sbjct 1 MRASFGLGRIAGVPVGVNWSVLVIFALIWWGLSANLFPVSYPGRSVVAYVFAGLAAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LLAHE++HAVVA+R G+ V+ +TLWLFGGV L GEA+TP A RIA GP SL + Sbjct 61 FLGLLAHEVSHAVVAKRNGLGVQGITLWLFGGVAELRGEARTPGAELRIAGVGPLVSLII 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 A FG +A+ L +++ V WLA +NLLL LFN+LP APLDGGRL+RA +W+ G Sbjct 121 GAFFGVIAMVLGVAGVHGLLLGVMAWLAGINLLLALFNVLPAAPLDGGRLLRAAVWKATG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D RA + AARAG V+ +VLI LGL F++G GG+WLA IGWF+ AA EE + Sbjct 181 DRTRASVVAARAGWVLGVVLIGLGLWRFLSGAGFGGLWLALIGWFLIGAASMEERQARMG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 G+RV + MT QP TA G + V DF+ Y+ RH+A P+ + DG GLV L ++R Sbjct 241 SALRGIRVGEVMTPQPQTASGELTVADFVDNYLFAYRHTALPLTE-DGRPVGLVTLDRVR 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V +RS+T++ +A + A P E LT LL R++ RALV +VGIV+ Sbjct 300 GVPSEQRSSTTLEAVACRADDLVLASPDEQLTDLLPRLSECAD-GRALVVANGNLVGIVS 358 Query 360 PSDVARLID 368 PSD++R + Sbjct 359 PSDISRAVQ 367 >gi|302869201|ref|YP_003837838.1| peptidase M50 [Micromonospora aurantiaca ATCC 27029] gi|302572060|gb|ADL48262.1| peptidase M50 [Micromonospora aurantiaca ATCC 27029] Length=379 Score = 286 bits (731), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 174/378 (47%), Positives = 229/378 (61%), Gaps = 3/378 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSL-ATMLPGTVGGYPAVVYWLLGAGGAVML 59 MR + LGRIAG V V+WSVLVI L W+L A++ P + G+ V Y G AV+ Sbjct 1 MRASFRLGRIAGVPVGVNWSVLVIFVLIAWALSASLFPSSYPGHSPVAYIAAGLAAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LLAHE+AHAVVA+R G+ VE +TLWLFGGV L GEAK P A RIA GP SL + Sbjct 61 FLGLLAHEVAHAVVAKRNGIEVEGITLWLFGGVAELKGEAKNPGAELRIAGVGPLVSLII 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 F A+A+ +A +++ WLA +N+LL +FN+LP APLDGGRL+RA +W+ G Sbjct 121 GVVFAAIAVAVAVTAGDGLLLGALSWLAGINVLLAIFNVLPAAPLDGGRLLRAAVWKFTG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +A + AARAG V+ +VLI LGL F G GG+WLA IGWF+ AA +EE Sbjct 181 DRTKASVVAARAGWVLGVVLIGLGLWRFFTGAGFGGLWLALIGWFLLGAAGQEERAARMG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 G+RV D MT QP TA G + V DF+ Y+ RHSA P+ DG GLV L ++R Sbjct 241 DALRGIRVGDVMTPQPQTASGDVTVADFVDHYLFAYRHSALPLT-VDGRPVGLVTLDRVR 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 +A RR++T++ +++ + ARP E LT LL R+ RALV +VGIV+ Sbjct 300 GIAADRRASTTLAEVSCRADELVLARPDEQLTDLLPRLNEC-TDGRALVVVDDQLVGIVS 358 Query 360 PSDVARLIDVYRLAQPEP 377 PSD++R + L Q P Sbjct 359 PSDISRAVQRGSLRQQVP 376 >gi|134098999|ref|YP_001104660.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] gi|291006761|ref|ZP_06564734.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] gi|133911622|emb|CAM01735.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] Length=402 Score = 284 bits (727), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 174/368 (48%), Positives = 232/368 (64%), Gaps = 4/368 (1%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M D I LGR+AG V +HWSV+ I+ L LA LP G+ AV Y L G AV+L Sbjct 1 MNDTIALGRVAGLRVGLHWSVVGIVVLVVVGLAGYTLPLLYPGHSAVGYVLSGVAAAVLL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 +ASLLAHE++HAVVARR GV+V+ +TLWL GGV L GEA +P A IA GPA SL L Sbjct 61 VASLLAHEVSHAVVARRNGVAVDGITLWLLGGVARLRGEAGSPGAELVIAVVGPAASLVL 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 + FG +A +A + T +V +V +LA +NL++ +FN++P APLDGGR++RA LWR G Sbjct 121 AVLFG-VAWWVADLMTAELVAAVLGYLALLNLVIAVFNMVPAAPLDGGRVLRAVLWRLGG 179 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +A + +ARAGR + VL+ALG E +A G VGG+W +GWFI + A EE + Sbjct 180 DRYKAAVWSARAGRGLGFVLVALGFVELLARG-VGGIWWVLLGWFIISVASAEEQQARVS 238 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 AGVRV D M++ TA G +VE+F+Q+ VL HS +P+ D G GLV LRQLR Sbjct 239 MALAGVRVRDVMSSPVETADGRRSVEEFVQKVVLDRPHSTFPLTDDSGRFNGLVTLRQLR 298 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V R +TSV +A+P VP A P EPL +L R++ R +V +VGIV+ Sbjct 299 SVPARERRSTSVAALAVPPERVPAAEPDEPLATVLPRLSA-DTGGRIVVLRADELVGIVS 357 Query 360 PSDVARLI 367 PSD++R + Sbjct 358 PSDISRAV 365 >gi|315504322|ref|YP_004083209.1| peptidase m50 [Micromonospora sp. L5] gi|315410941|gb|ADU09058.1| peptidase M50 [Micromonospora sp. L5] Length=379 Score = 276 bits (705), Expect = 5e-72, Method: Compositional matrix adjust. Identities = 174/379 (46%), Positives = 229/379 (61%), Gaps = 3/379 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSL-ATMLPGTVGGYPAVVYWLLGAGGAVML 59 MR + LGRIAG V V+WSVLVI L W+L A++ P + G+ V Y G AV+ Sbjct 1 MRASFRLGRIAGVPVGVNWSVLVIFVLIAWALSASLFPSSYPGHSPVAYIAAGLAAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LLAHE+AHAVVA+R G+ VE +TLWLFGGV L GEAK P A RIA GP SL + Sbjct 61 FLGLLAHEVAHAVVAKRNGIEVEGITLWLFGGVAELKGEAKDPGAELRIAGVGPLVSLII 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 F A+A+ +A +++ WLA +N+LL +FN+LP APLDGGRL+RA +W+ G Sbjct 121 GVVFAAIAVAVAAAGGHGLLLGALAWLAGINVLLAIFNVLPAAPLDGGRLLRAAVWKFTG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +A + AARAG V+ +VLI LGL F G GG+WLA IGWF+ AA +EE Sbjct 181 DRTKASVVAARAGWVLGVVLIGLGLWRFFTGAGFGGLWLALIGWFLLGAAGQEERAARMG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 G+RV D MT QP TA G + V DF+ Y+ RHSA P+ DG GLV L ++R Sbjct 241 DALRGIRVGDVMTPQPQTASGDLTVADFVDHYLFAYRHSALPLT-VDGRPVGLVTLDRVR 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 +A RR++T++ +++ + ARP E LT LL R+ RALV +VGIV+ Sbjct 300 GIAADRRASTTLAEVSCRADELVLARPDEQLTDLLPRLNECSD-GRALVVVDDQLVGIVS 358 Query 360 PSDVARLIDVYRLAQPEPT 378 PSD++R + L Q P Sbjct 359 PSDISRAVQRGSLRQQVPV 377 >gi|238060469|ref|ZP_04605178.1| peptidase M50 [Micromonospora sp. ATCC 39149] gi|237882280|gb|EEP71108.1| peptidase M50 [Micromonospora sp. ATCC 39149] Length=380 Score = 267 bits (682), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 170/369 (47%), Positives = 219/369 (60%), Gaps = 3/369 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 MR + +GRIAG V V+WSVLVI L W LA + P + P Y L G AV+ Sbjct 1 MRASFRIGRIAGVPVGVNWSVLVIFGLIAWGLAASQFPRSYPDQPTWAYVLAGLSAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LLAHE++HAVVA+R G+ V +TLWLFGGV L GEA+ P A RIA GP SL + Sbjct 61 FLGLLAHEVSHAVVAKRNGLEVSGITLWLFGGVAELRGEARDPGAELRIAGVGPLVSLVI 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 FG A+ LA +++ WLA +N+LL +FN+LP APLDGGRL+RA +W+ G Sbjct 121 GFFFGGFAVLLALTGVGGLLLGALAWLAGINILLAVFNVLPAAPLDGGRLLRAAVWKATG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D RA + AARAG V+ +LI LGL +FV G G+WLA IGWF+ AA EE Sbjct 181 DRTRASVVAARAGWVLGALLIGLGLWQFVRGAGFSGLWLALIGWFLIGAAGMEERHARMG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 GVRVAD MT QP TA G + V DF+ Y+ RHSA P+ D DG GLV L ++R Sbjct 241 SALRGVRVADVMTPQPQTASGDMTVADFVDHYLFAYRHSALPLTD-DGRPVGLVTLDRVR 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 + RS T++ ++A + A P E L LL R++ RALV G +VGIV+ Sbjct 300 GIPAEARSATTLAEVACRADQLVLADPDEQLNDLLPRLSECAD-GRALVVAGGRLVGIVS 358 Query 360 PSDVARLID 368 PSD++R + Sbjct 359 PSDISRAVQ 367 >gi|159039184|ref|YP_001538437.1| peptidase M50 [Salinispora arenicola CNS-205] gi|157918019|gb|ABV99446.1| peptidase M50 [Salinispora arenicola CNS-205] Length=381 Score = 263 bits (672), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 167/366 (46%), Positives = 216/366 (60%), Gaps = 3/366 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSL-ATMLPGTVGGYPAVVYWLLGAGGAVML 59 MR + LGRI G V V+WSVLVI L W+L A P T P Y L G AV+ Sbjct 1 MRASFRLGRIVGVPVGVNWSVLVIFLLIAWALSANQFPRTYPDRPGFAYVLAGLAAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LLAHE++HAVVA+R G+ V +TLWLFGGV L GEA P A RIA GP SL + Sbjct 61 FLGLLAHEVSHAVVAKRNGLEVGGITLWLFGGVAELKGEAPNPGAELRIAGIGPLVSLLI 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 A FG +A LA + + WLA +N+LL +FN+LP APLDGGRL+RA +W+ G Sbjct 121 GAFFGVIAAGLAMTGYNGLWLGALAWLAGINVLLAVFNVLPAAPLDGGRLLRAAVWKATG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +A + AARAG V+ +LI LG +F AGG GG+WL IGWF+ AA EE + Sbjct 181 DRTKASVVAARAGWVLGALLIGLGFWQFFAGGGFGGLWLILIGWFLIGAAGMEERQARMG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 G+RVAD MT QP TA G + V DF+ Y+ RHSA P+ + D + GLV L ++R Sbjct 241 SALHGLRVADVMTPQPQTASGDMTVADFVGHYLFAYRHSALPLVEDDRPV-GLVTLDRVR 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V +R T++ ++A + A P E L LL R++ RALV +VGIV+ Sbjct 300 GVPADQRYGTTLAEVACRADDLVLASPDESLNELLPRLSECAD-GRALVVVDGRLVGIVS 358 Query 360 PSDVAR 365 PSD++R Sbjct 359 PSDISR 364 >gi|257055198|ref|YP_003133030.1| Zn-dependent protease [Saccharomonospora viridis DSM 43017] gi|256585070|gb|ACU96203.1| Zn-dependent protease [Saccharomonospora viridis DSM 43017] Length=388 Score = 261 bits (666), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 169/368 (46%), Positives = 218/368 (60%), Gaps = 2/368 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M I LG I G + VHWSVL IL + +L P V GYPA Y L AV+ Sbjct 1 MSPTITLGTIFGVRIGVHWSVLGILAILLVALGFRSWPVLVPGYPAGAYVLAALAAAVLF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LASLLAHELAHAVVARR G+ V+ +TLWL GGV +L EA+TP A RIA AGP TS+ Sbjct 61 LASLLAHELAHAVVARRQGIEVKDITLWLLGGVASLRSEARTPGAELRIAAAGPLTSVLA 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 +A FGALA V P +V+ + +LA N ++ +FNL+P +PLDGGR++RA LW G Sbjct 121 AAVFGALAWLFVAVDAPTLVVLLFTYLAVFNTVIAVFNLIPASPLDGGRILRAGLWAWKG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D RA + +ARAG+ + LI G + + G G+W IG FI A A EE + Sbjct 181 DRARAAVWSARAGQGFGIFLILAGAWQLLFIGTGNGLWWILIGLFIAAVASAEEQQARLG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 A RV + MT P T ++V DF+ VL RH+A+PV D DG + GLV L ++R Sbjct 241 STLADTRVFEVMTPDPDTTDADLSVNDFLHDVVLTRRHAAFPVVDADGRVEGLVTLNRMR 300 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V +R +V +IA PL VPT +P PLT LL R+ P RALV + +VGIVT Sbjct 301 SVPSEKREHLTVREIASPLTEVPTTKPDTPLTDLLPRLNE-APDGRALVFDEDRLVGIVT 359 Query 360 PSDVARLI 367 P+DV+R + Sbjct 360 PTDVSRAV 367 >gi|145595913|ref|YP_001160210.1| peptidase M50 [Salinispora tropica CNB-440] gi|145305250|gb|ABP55832.1| peptidase M50 [Salinispora tropica CNB-440] Length=381 Score = 259 bits (661), Expect = 7e-67, Method: Compositional matrix adjust. Identities = 166/366 (46%), Positives = 218/366 (60%), Gaps = 3/366 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSL-ATMLPGTVGGYPAVVYWLLGAGGAVML 59 MR + LGRI G V V+WSVLVI L W L A P T P + Y L G AV+ Sbjct 1 MRASFRLGRIVGVPVGVNWSVLVIFLLIAWLLSANQFPRTYPDQPGIAYLLAGLAAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LLAHE++HAV+A+R G+ V +TLWLFGGV L GEA P A RIA GP SL + Sbjct 61 FLGLLAHEVSHAVIAKRNGLEVGGITLWLFGGVAELKGEAPNPGAELRIAGIGPLVSLLI 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 FGA+A LA + + WLA +N+LL +FN+LP APLDGGRL+RA +W+ G Sbjct 121 GVFFGAIAAGLAMTGYDGLWLGALAWLAGINVLLAVFNVLPAAPLDGGRLLRAAVWKATG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +A + AARAG V+ +LI LG +F AGG GG+WL IGWF+ AA EE + Sbjct 181 DRTKASVVAARAGWVLGALLIGLGFWQFFAGGGFGGLWLILIGWFLIGAATMEERQARMG 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 +G+R+A+ MT QP TA G + V DFI+ Y+ R+SA P+ D + GLV L ++R Sbjct 241 SALSGIRIAEVMTPQPQTAAGDMTVADFIEHYLFAYRYSALPLVADDRPV-GLVTLDRIR 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V RRS T++ ++A + A P E L LL R+ RALV + +VGIV+ Sbjct 300 RVPADRRSATTLAEVACRTDELVLASPDESLNELLPRLTDCAD-GRALVVDDGQLVGIVS 358 Query 360 PSDVAR 365 PSD++R Sbjct 359 PSDISR 364 >gi|269124430|ref|YP_003297800.1| peptidase M50 [Thermomonospora curvata DSM 43183] gi|268309388|gb|ACY95762.1| peptidase M50 [Thermomonospora curvata DSM 43183] Length=392 Score = 258 bits (660), Expect = 9e-67, Method: Compositional matrix adjust. Identities = 176/376 (47%), Positives = 229/376 (61%), Gaps = 1/376 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M +++ LGRIAG V ++ SVLVI+ + LA + P + GY Y L A+ Sbjct 1 MNESVRLGRIAGIPVGLNVSVLVIVVILVVGLAFGLFPESFAGYSTAAYLLAALLAALAF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LASLLAHELAHAVVA+R GV VE +TLWL GGV L GE +TP+A F IA GP TS+AL Sbjct 61 LASLLAHELAHAVVAKRHGVEVEGITLWLLGGVARLHGEPRTPRADFLIAVVGPLTSVAL 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 A F LA+ + + + +LA +N++L +FNL+P APLDGGR++RA LWR G Sbjct 121 GAVFWLLALAVGWATGSPLAVGTLVYLALLNVVLAVFNLIPAAPLDGGRVLRAALWRWRG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D A I AARAGR VLI LGL + V G V G+WLA IGWF+ AA EE + Q Sbjct 181 DRHAAAISAARAGRAFGFVLITLGLLQVVTGMGVNGLWLALIGWFLVNAAAAEEQQTRVQ 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 + GVRV D MT P TA V DFI + VL R S YP+ D G + GLV L ++R Sbjct 241 TVLGGVRVGDVMTPHPLTAHPDETVADFIHQVVLARRFSTYPLVDELGRLDGLVTLNRIR 300 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 DV + R+TT++ +IA PL +P RP++PLT LL M+ +++ V+G+VT Sbjct 301 DVPAALRATTTLREIACPLEGIPLGRPEQPLTELLANMSGCTDGRAVVLSPDRRVIGLVT 360 Query 360 PSDVARLIDVYRLAQP 375 PSD++R I V L P Sbjct 361 PSDISRAIQVGELTGP 376 >gi|345016148|ref|YP_004818502.1| peptidase M50 [Streptomyces violaceusniger Tu 4113] gi|344042497|gb|AEM88222.1| peptidase M50 [Streptomyces violaceusniger Tu 4113] Length=383 Score = 243 bits (619), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 163/394 (42%), Positives = 211/394 (54%), Gaps = 18/394 (4%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M ++ +GR+ G + +HWSV V++ L + L LP G VY L GAV+L Sbjct 1 MNGSVRVGRVLGVPLRMHWSVPVLIVLLAYGLGHKTLPAWTPGRTGTVYALASVVGAVLL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSL-- 117 + SLL HE AHAV ARR GVSVE VTLW GG+T +G +T AF +A GP TSL Sbjct 61 MGSLLLHEAAHAVAARRKGVSVEDVTLWALGGMTKMG-RPRTAGVAFWVAVIGPLTSLVI 119 Query 118 ---ALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYL 174 L A G +T GV T ++ WL NLLLG+FNLLP APLDGGR+V+A + Sbjct 120 GGVTLGAGIGVHTLTGWGVPTAVLI-----WLGWANLLLGVFNLLPAAPLDGGRVVQAAI 174 Query 175 WRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEET 234 W R GD RA A R+G+++ + LIA+G F+ G GG+WL+ IG F+ A E Sbjct 175 WWRTGDRERADRAAGRSGQILGMALIAIGWISFLRGN-TGGLWLSLIGLFMVIIANAERQ 233 Query 235 RISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVA 294 R GVRVADAM+A W+ V FI RHS P+ D +G +G V Sbjct 234 RAGINTALRGVRVADAMSAPVAAGADWLTVGRFIDDVAAHSRHSVMPLLDFEGQPSGAVR 293 Query 295 LRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAV 354 LR L V R T V D+A PL A P E L+ +LER P G LV + + Sbjct 294 LRALAAVPTEARETQRVRDVATPLSRCTVAEPGELLSEVLERARPGGGGMPVLVVDHGQL 353 Query 355 VGIVTPSDVARLIDVYRLAQPEPTFTTSPQDADR 388 GI+T DV RL ++ L TT+P ++ R Sbjct 354 EGIITMHDVNRLFQLHGLG-----ITTAPPESTR 382 >gi|86743169|ref|YP_483569.1| peptidase M50 [Frankia sp. CcI3] gi|86570031|gb|ABD13840.1| peptidase M50 [Frankia sp. CcI3] Length=381 Score = 237 bits (605), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 171/378 (46%), Positives = 222/378 (59%), Gaps = 2/378 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVML 59 MR +GRIAG + VHWSVL+I + + LA LP G+ VVYW+ AV+ Sbjct 1 MRATFVVGRIAGVRIGVHWSVLLIFGIIAFGLAQGRLPQAYPGHALVVYWVAALAAAVVF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 ASLLAHE+AHAVVA+R GV+V+ + LWL GGV L EA +P A RIA GP SL L Sbjct 61 FASLLAHEVAHAVVAQRNGVAVDDIVLWLLGGVARLKSEASSPAAELRIAGVGPLVSLLL 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 F A LA P ++I V WLA +NLLL +FN P APLDGGRL+RA+LW R G Sbjct 121 GGLFVLGAWLLALASAPELLIEVVAWLAGINLLLAVFNAFPAAPLDGGRLLRAFLWWRTG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +RA GA AGRV+ +L+ LGL F+ GG G +WLA IG F+ AAA E + + Sbjct 181 DRLRATAGATAAGRVLGWLLVVLGLLVFMRGGGFGWLWLALIGSFLIAAATAEGRQAQLR 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 + AGV V DAMT +P T P + V D + + RHSA+PV +G+ GLV L + Sbjct 241 GVLAGVPVHDAMTTKPLTVPAALTVADLLAGPLYRYRHSAFPVTGENGAPVGLVTLDGAK 300 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V P + T +V ++ +PL A P +PL LL RM P G R LV + +VGI++ Sbjct 301 QVPPEKSGTVTVSEVMVPLSRTTIAGPDDPLADLLPRMEP-GAEHRVLVMDQGRLVGILS 359 Query 360 PSDVARLIDVYRLAQPEP 377 SD++R + A P P Sbjct 360 LSDISRTVTWLMNAAPGP 377 >gi|284990848|ref|YP_003409402.1| peptidase M50 [Geodermatophilus obscurus DSM 43160] gi|284064093|gb|ADB75031.1| peptidase M50 [Geodermatophilus obscurus DSM 43160] Length=396 Score = 236 bits (602), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 172/374 (46%), Positives = 216/374 (58%), Gaps = 2/374 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M + LGRIAG V V+ SVLVI+ + LA P + G A Y G AV Sbjct 1 MSETFSLGRIAGIRVGVNASVLVIVLIIAGGLAFGRFPLVLPGRGAAAYVAAGVAAAVAF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 LASLLAHELAHA+VARR GV VE +TLWL GGV L A+TP A FRIA GP TSL L Sbjct 61 LASLLAHELAHALVARRNGVEVEGITLWLLGGVARLRSGARTPGAEFRIAGVGPLTSLVL 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 A A+ + ++V +LA +N+ L +FNL+P APLDGGRL+RA LWR G Sbjct 121 GVLLAAGAVLARLAGADGLPVAVLDYLAGINVALAVFNLVPAAPLDGGRLLRALLWRLRG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D+ + + AARAGR LIALG + V G GG+WLA +G F+ AA EE Sbjct 181 DAWSSAVTAARAGRFFGFALIALGFLQLVTGRGFGGLWLALVGLFVVNAATAEEQHAQVS 240 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 G+ V M+ A + VE F+ L R S YP+ D G++ GLV L +LR Sbjct 241 SRLGGLTVGAVMSGPALVADPDLTVERFLHEVALVRRFSTYPLVDPSGALVGLVTLNRLR 300 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V P+ R+TT + D+A P +P ARP EPLT LL RM RA+V +GS VVG+V+ Sbjct 301 SVPPAARATTRLRDVACPPAEIPVARPGEPLTELLPRMEGCS-DGRAVVLDGSRVVGVVS 359 Query 360 PSDVARLIDVYRLA 373 PSDVAR + + LA Sbjct 360 PSDVARTLQLADLA 373 >gi|333919806|ref|YP_004493387.1| peptidase M50 [Amycolicicoccus subflavus DQS3-9A1] gi|333482027|gb|AEF40587.1| Peptidase M50 [Amycolicicoccus subflavus DQS3-9A1] Length=372 Score = 231 bits (588), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 143/366 (40%), Positives = 205/366 (57%), Gaps = 5/366 (1%) Query 2 RDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLL 60 R + +G + G + HWSVL I L T LAT +LP V G Y + GAV+ L Sbjct 3 RGRVSMGTVRGIPIGAHWSVLAIFGLITIILATSILPAAVPGRSGAAYVPIAIVGAVVFL 62 Query 61 ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS 120 ASLLAHELAHAVVA++ V V+ +TLWL GGV L + +A FRIA GP S+ ++ Sbjct 63 ASLLAHELAHAVVAQKHDVRVKRITLWLLGGVAELEENPRDARAEFRIAIVGPVASMGIA 122 Query 121 -ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 FGA +T + + ++++ WL VN ++ +FN+LPGAPLDGGR++RA+LWRR G Sbjct 123 IMAFGAAYLTRSWL--DPLMLAAMIWLGLVNAIVAVFNMLPGAPLDGGRVLRAFLWRRTG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D +A + AA GR++ IALGL + + G GG+WL IGWF+ AA E + + Sbjct 181 DRAQASLKAAGIGRILGFSFIALGLIQTILGS-PGGLWLVLIGWFMLMAASAERATETAR 239 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 F G+R D M+ AP W V+ F+ R R S +PV DG G+V+ +L Sbjct 240 AQFTGIRTGDVMSQVFDVAPEWWYVDAFLARTPHTSRGSVFPVVRYDGEPVGVVSGAELW 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 +++ R T+VG +A PL L +++ R + +V +GSA+ G++T Sbjct 300 NISEKDRLNTTVGQVARPLAPGSVVGIDADLGSVVTRTPLQAGQDIVVVMDGSAIAGVLT 359 Query 360 PSDVAR 365 DV R Sbjct 360 AEDVLR 365 >gi|119510923|ref|ZP_01630046.1| protease family protein [Nodularia spumigena CCY9414] gi|119464451|gb|EAW45365.1| protease family protein [Nodularia spumigena CCY9414] Length=375 Score = 231 bits (588), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 128/366 (35%), Positives = 204/366 (56%), Gaps = 3/366 (0%) Query 7 LGRIAGFVVNVHWSVLVILWLFTWSL-ATMLPGTVGGYPAVVYWLLGAGGAVMLLASLLA 65 LG I GF + V S +I +L W+L A + P + G+ Y+ +G ++ ASLLA Sbjct 6 LGSIFGFEIRVDLSWFLIFFLVLWTLSAGIFPTSYPGFGNATYFGMGIVATLLFFASLLA 65 Query 66 HELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGA 125 HEL+H VAR G+ VE +TL++FGGV+ +A+TP F+IA GP SL L+ FG Sbjct 66 HELSHTFVARAKGIPVEGITLFIFGGVSRTRMDAETPGDEFQIAGVGPLVSLLLAGFFGL 125 Query 126 LAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSVRAG 185 + + + +LA +NL L +FN+LPG PLDGGR+ R+ +W+ G+ +A Sbjct 126 IWYVGINAGWSVVFTGIFAYLAVINLALAIFNMLPGFPLDGGRVFRSMIWKYTGNIKKAT 185 Query 186 IGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLFAGV 245 A+ G+ +A +LIA G E AG ++GG+WL IGWF++ AA + + GV Sbjct 186 KIASTGGKWLAYLLIAFGALEMFAGAILGGLWLILIGWFLYNAAETSYEELLLRTSLKGV 245 Query 246 RVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAPSR 305 + + MT P T +N+++ + Y L R+ ++PV +D G++ L Q++D+ Sbjct 246 KAREIMTPHPETVSPEMNLQELVDTYFLSRRYHSFPVT-QDSHPVGIITLNQVKDIPREE 304 Query 306 RSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVAR 365 +V D +P+ + TARP+E ++ +L++M G R R LV + + GI+T D+A Sbjct 305 WKYRTVKDTMIPVENRVTARPEEQMSQVLQKMQDSGVR-RVLVIQNDLLRGIITAHDLAN 363 Query 366 LIDVYR 371 + R Sbjct 364 WLQRQR 369 >gi|296270589|ref|YP_003653221.1| peptidase M50 [Thermobispora bispora DSM 43833] gi|296093376|gb|ADG89328.1| peptidase M50 [Thermobispora bispora DSM 43833] Length=405 Score = 230 bits (587), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 164/391 (42%), Positives = 219/391 (57%), Gaps = 9/391 (2%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVML 59 MR ++ LGRI G V ++WSVLVI+ + + LA P G P+ Y L G A++ Sbjct 1 MRSSVHLGRIFGVPVGINWSVLVIIAILVFGLAFGRFPFDYPGLPSWAYLLAGVVAALLF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 L SLLAHELAHAV+A+R G+ V +TLWL GGV L GE++TP A +IA GP TS+A Sbjct 61 LGSLLAHELAHAVMAKRHGIEVAGITLWLLGGVAELRGESRTPAADLKIAGIGPLTSIAA 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 FG + P ++ + +LA VN++L +FNL+P APLDGGR++RA LWR G Sbjct 121 GVVFGIAWWLVDSFGGPPLLAGMFGYLAVVNVILAVFNLIPAAPLDGGRVLRAALWRLWG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAG-GLVGGVWLAFIGWFIFAA-AREEETRIS 237 D VRA + AARAGR LI LG E G G G + + + AA A E++TR+ Sbjct 181 DRVRAAVAAARAGRAFGYGLITLGFIEIFFGVGFQGLWLILLGLFLVHAASAEEQQTRLG 240 Query 238 TQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQ 297 GVR AD M+ P A V + I R VL R S YP+ D G GL+ L + Sbjct 241 AS--LHGVRAADVMSEHPIVAHPDETVAELIDRLVLRHRMSTYPLVDERGVFQGLLTLNR 298 Query 298 LRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSA-VVG 356 +R V +TT +GDIA P VP ARP E T LL RM P RA+V + ++G Sbjct 299 IRQVPRPAWTTTRLGDIACPAPEVPQARPDELFTDLLARMNG-APDGRAVVLDAEHRLIG 357 Query 357 IVTPSDVARLIDVYRLAQPEPTFTTSPQDAD 387 ++TP D++ +I L P +P+ AD Sbjct 358 LITPRDISHMIQTVDLRSAHPYH--APRGAD 386 >gi|254380696|ref|ZP_04996062.1| peptidase M50 [Streptomyces sp. Mg1] gi|194339607|gb|EDX20573.1| peptidase M50 [Streptomyces sp. Mg1] Length=391 Score = 228 bits (581), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 166/371 (45%), Positives = 204/371 (55%), Gaps = 4/371 (1%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVML 59 M+ LGRIAG V VHWS+LVI L LA LP G VYWL+G A + Sbjct 1 MKPTFVLGRIAGVRVGVHWSILVIFMLIALGLAEGRLPDAYPGRSWWVYWLVGLLAAALF 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 ASLLAHELAHAVVARR V+V+ + LWL GGV L EA TP A RIA GP SLAL Sbjct 61 FASLLAHELAHAVVARRNKVTVDDIVLWLLGGVARLRSEASTPAAELRIAGVGPLVSLAL 120 Query 120 SATFGALAITLAGVRT-PAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRH 178 F ALA L G P + WLA +NLLL LFN +P APLDGGRL+RA+LW R Sbjct 121 GVGF-ALAGWLVGTAAGPGLASEALMWLAVINLLLALFNSVPAAPLDGGRLLRAFLWWRT 179 Query 179 GDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRIST 238 GD RA GAA AGR L+ GL F G +VGG+WL I WF+ AAA E + Sbjct 180 GDRARATAGAAAAGRGFGWFLLLFGLLLFARGDVVGGLWLVMIAWFLIAAATAEGQQAQL 239 Query 239 QQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDG-SITGLVALRQ 297 + + AGV V AMT P T P + + + HSA+PV DG S GL+ L Sbjct 240 RAVLAGVAVRQAMTPSPVTVPAGLTIAALLADPRYRYHHSAFPVTGDDGRSPVGLLTLSA 299 Query 298 LRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGI 357 VA +R T V ++ +P V P + L +L +M G + +V E ++VGI Sbjct 300 AGRVAERQRGVTRVREVMVPRSDVTVVGPDDQLAEVLPQMLAGGGQRALVVDESGSLVGI 359 Query 358 VTPSDVARLID 368 V SD++R + Sbjct 360 VASSDISRTVS 370 >gi|297159306|gb|ADI09018.1| peptidase M50 [Streptomyces bingchenggensis BCW-1] Length=383 Score = 224 bits (572), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 148/384 (39%), Positives = 201/384 (53%), Gaps = 3/384 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M ++ +G + G + +HWSV V++ L + L LP G+ VVY GA +L Sbjct 1 MNGSMRVGHVLGVPLRMHWSVPVLVALLAYGLGHETLPAWTPGHSNVVYAAASVIGAALL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 + SLL HE AHAV AR+ GV+V+ VTLW GG+T +G +T A +A +GP TSL + Sbjct 61 MGSLLLHEAAHAVAARKKGVAVQDVTLWALGGMTQMG-RPRTAGVALLVAVSGPITSLVI 119 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 I G+ I ++ WL NLLLG+FNLLP APLDGGR+V+A LW R G Sbjct 120 GGVAIGAGIGAHGLIGWGIPAALLLWLGWANLLLGVFNLLPAAPLDGGRVVQAVLWWRTG 179 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D RA A R+G++ + +IA G F+ G GG+W A IG F+ A E + Sbjct 180 DRERAERAAGRSGQIFGMAMIAFGWVAFIRGS-TGGLWFALIGLFMVIIANAERQHATLT 238 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 + GVRVADAM+ W+ V+ FI RHS PV D +G +GLV+LR L Sbjct 239 ETLRGVRVADAMSHPVAAGADWLTVDRFIDEVAAPARHSVLPVLDFEGRPSGLVSLRGLA 298 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V R V D+A PL A P + L ++ER A G LV + + GIVT Sbjct 299 AVPSGNRGMQRVRDVATPLSRCTLAVPGDLLNEVMERGARPGAGMPILVVDHGHLEGIVT 358 Query 360 PSDVARLIDVYRLAQPEPTFTTSP 383 DV RL ++ L ++P Sbjct 359 AHDVTRLFQLHALGATAAPPKSTP 382 >gi|291006839|ref|ZP_06564812.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] Length=399 Score = 223 bits (569), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 160/383 (42%), Positives = 219/383 (58%), Gaps = 4/383 (1%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATM-LPGTVGGYPAVVYWLLGAGGAVML 59 M IPLGRIAG V +HWSV I+ + ++LA P G+ + Y + G + +L Sbjct 1 MNANIPLGRIAGIRVGLHWSVAGIVVVIVFALAGYRFPAVYPGHSQIAYTVAGIAASGLL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 + SLL HELAHAVVARR GV+VE +TLWL GGV L EA++P A RIA GP S AL Sbjct 61 VCSLLGHELAHAVVARRNGVAVEGITLWLLGGVARLRDEARSPGADLRIAIVGPTASAAL 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 + FGALA + V P +V++V ++ +NLLL LFNLLP APLDGGR++RA LWR G Sbjct 121 AVAFGALAWSAYVVGAPELVMAVLGYMTLLNLLLALFNLLPAAPLDGGRVLRAVLWRWRG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D RA + +ARAG ++ +L+ G+ + + G+W +G FI AAA EE + Sbjct 181 DRYRAALWSARAGLGLSYLLVLGGIVQLIIES-TAGLWWVLLGMFIAAAAMTEERQARAG 239 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 AG+RV D M+ G + +E F+ R + PV D G I G++A R + Sbjct 240 AALAGIRVRDVMSHPVAAVDGNLTIEQFL-RTAPSRSRTICPVLDPTGRIGGVIAGRDIS 298 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V TT++ +A P + TA P+EPLTALL R++ R LV +VGIV Sbjct 299 AVPQPEWGTTALHRVARPTECIATAAPEEPLTALLPRLSEEA-EGRVLVLAEDELVGIVA 357 Query 360 PSDVARLIDVYRLAQPEPTFTTS 382 PSD++R + L P P +T+ Sbjct 358 PSDISRAAEERGLHLPVPGASTA 380 >gi|337769503|emb|CCB78216.1| Zn-dependent protease [Streptomyces cattleya NRRL 8057] Length=370 Score = 220 bits (561), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 154/367 (42%), Positives = 217/367 (60%), Gaps = 14/367 (3%) Query 7 LGRIAGFVVNVHWSVLVILWLFTWSLATM-LPGTVGGYPAVVYWLLGAGGAVMLLASLLA 65 +GR+ G + +HWS ++L +F +SL LP V G+ Y + G GAV+LL SLL Sbjct 7 MGRLFGVPLRLHWSAPLLLLVFGYSLGRQTLPVWVPGHSRAAYAVGGVAGAVLLLGSLLL 66 Query 66 HELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGA 125 HE AHA+ ARRAGV VE +TLW GG+T +G A++P+AA IA +GP SLA FG Sbjct 67 HESAHALTARRAGVKVEDMTLWALGGMTRMG-RAESPRAALAIAVSGPLVSLA----FGG 121 Query 126 LAITLA-GVRT-PAIVI--SVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDS 181 A+ +A GV T PA+++ +V WLA N+LLG+FNLLP APLDGGR++R+ +W D Sbjct 122 AALGVARGVATAPALLLPAAVLTWLAWANVLLGVFNLLPAAPLDGGRVLRSAVWWWGKDR 181 Query 182 VRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQL 241 RA A R+GRV+ + L+A+G F+ G GG+WL +G+F+ + A E R + Sbjct 182 ERADQVAGRSGRVIGVALVAVGGIGFLR-GWGGGLWLVLVGFFVSSTATAELRRSMLESA 240 Query 242 FAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDV 301 GV V M+A P W V+ F++R RHSA+ + D DG +G+V LR+L V Sbjct 241 LRGVTVGRTMSAPVVFGPDWFTVDRFLERMAEAPRHSAFALVDFDGRPSGIVTLRRLAMV 300 Query 302 APSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPS 361 AP+RR V D+A+ + P ARP E L ++ R+ +V E + GIVT Sbjct 301 APARRDEVRVRDVAV---ACPVARPDEQLLDVMGRLGTASGARILVVDEEGRLAGIVTAH 357 Query 362 DVARLID 368 D+ RL+ Sbjct 358 DITRLLQ 364 >gi|134099062|ref|YP_001104723.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] gi|133911685|emb|CAM01798.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] Length=393 Score = 217 bits (553), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 156/377 (42%), Positives = 216/377 (58%), Gaps = 4/377 (1%) Query 7 LGRIAGFVVNVHWSVLVILWLFTWSLATM-LPGTVGGYPAVVYWLLGAGGAVMLLASLLA 65 +GRIAG V +HWSV I+ + ++LA P G+ + Y + G + +L+ SLL Sbjct 1 MGRIAGIRVGLHWSVAGIVVVIVFALAGYRFPAVYPGHSQIAYTVAGIAASGLLVCSLLG 60 Query 66 HELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGA 125 HELAHAVVARR GV+VE +TLWL GGV L EA++P A RIA GP S AL+ FGA Sbjct 61 HELAHAVVARRNGVAVEGITLWLLGGVARLRDEARSPGADLRIAIVGPTASAALAVAFGA 120 Query 126 LAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSVRAG 185 LA + V P +V++V ++ +NLLL LFNLLP APLDGGR++RA LWR GD RA Sbjct 121 LAWSAYVVGAPELVMAVLGYMTLLNLLLALFNLLPAAPLDGGRVLRAVLWRWRGDRYRAA 180 Query 186 IGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLFAGV 245 + +ARAG ++ +L+ G+ + + G+W +G FI AAA EE + AG+ Sbjct 181 LWSARAGLGLSYLLVLGGIVQLIIES-TAGLWWVLLGMFIAAAAMTEERQARAGAALAGI 239 Query 246 RVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAPSR 305 RV D M+ G + +E F+ R + PV D G I G++A R + V Sbjct 240 RVRDVMSHPVAAVDGNLTIEQFL-RTAPSRSRTICPVLDPTGRIGGVIAGRDISAVPQPE 298 Query 306 RSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVAR 365 TT++ +A P + TA P+EPLTALL R++ R LV +VGIV PSD++R Sbjct 299 WGTTALHRVARPTECIATAAPEEPLTALLPRLSEEA-EGRVLVLAEDELVGIVAPSDISR 357 Query 366 LIDVYRLAQPEPTFTTS 382 + L P P +T+ Sbjct 358 AAEERGLHLPVPGASTA 374 >gi|302544335|ref|ZP_07296677.1| putative membrane protein [Streptomyces hygroscopicus ATCC 53653] gi|302461953|gb|EFL25046.1| putative membrane protein [Streptomyces himastatinicus ATCC 53653] Length=383 Score = 214 bits (545), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 155/390 (40%), Positives = 207/390 (54%), Gaps = 14/390 (3%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLA-TMLPGTVGGYPAVVYWLLGAGGAVML 59 M ++ +G + G + +HWS V++ L + L LP G +VY + GA++L Sbjct 1 MNGSVRVGHVLGVPLRMHWSAPVLIVLLAYGLGRETLPAWTPGRTGLVYAVASVIGALLL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 + SLL HE AHAV AR GVSVE VTLW GG+T +G +T A +A +GP TSLA+ Sbjct 61 MGSLLLHEAAHAVTARGKGVSVEDVTLWALGGMTQMG-RPRTAGIALLVAISGPLTSLAI 119 Query 120 SATFGALAI---TLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWR 176 I LAG PA V+ WL NLLLG+FNLLP APLDGGR+V+A LW Sbjct 120 GGVAVGAGIGANALAGWGVPAAVLI---WLGWANLLLGVFNLLPAAPLDGGRVVQAVLWW 176 Query 177 RHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRI 236 R GD RA A R+G++ ++LIALG FV G GG+W+A +G F+ A E R Sbjct 177 RTGDRDRAERAAGRSGQIFGILLIALGWFSFVRGE-GGGLWIALVGLFMLVIANAERQRA 235 Query 237 STQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALR 296 GVR DAM++ T W+ V FI RHS P+ D +G ++G+V LR Sbjct 236 GINTALRGVRAGDAMSSPVATGADWLPVGRFIDEVAAHSRHSVMPLLDFEGRVSGVVELR 295 Query 297 QLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVG 356 L V R V ++A PL A E L+ +LER P LV + + G Sbjct 296 ALAAVPAGMREERRVREVATPLSRCTVATSDELLSEVLERARPGAGGMPVLVVDDGHLEG 355 Query 357 IVTPSDVARLIDVYRLAQPEPTFTTSPQDA 386 IVT DV+RL ++ L TT+P +A Sbjct 356 IVTSHDVSRLFQLHSLG-----ITTAPPEA 380 >gi|91202292|emb|CAJ75352.1| conserved hypothetical protein [Candidatus Kuenenia stuttgartiensis] Length=369 Score = 213 bits (541), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 124/370 (34%), Positives = 205/370 (56%), Gaps = 9/370 (2%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATM-LPGTVGGYPAVVYWLLGAGGAVML 59 ++ A +G + G + VH++ ++ L TWSL+T+ P P YWL GA A++L Sbjct 5 LQGAWKIGTVMGIPIRVHFTWFIVFGLITWSLSTLYFPKAAPDLPVTSYWLKGALAALLL 64 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 AS+ HELAH +VA+R +S+ES+TL++FGGV+ + E P+A F IA AGP +S L Sbjct 65 FASVAFHELAHCIVAKRYKISIESITLFIFGGVSRMKSEPPHPRAEFNIAIAGPLSSFFL 124 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 A F +++ ++G + +LA +NL++G+FNL+PG PLDGGR++RA LW ++ Sbjct 125 YALFYFISMGVSGSMKTLFI-----YLAQINLIIGIFNLIPGFPLDGGRVLRAILWSKNK 179 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 + A AA GR +AL + GL G+ GG+WL IGWF+F AA+ + + Q Sbjct 180 NFFSATQKAAGVGRKIALFFVFFGLFSLFT-GVPGGLWLMLIGWFLFTAAQASYQQSALQ 238 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 + GV+V D M T +++E+ + Y L + +PV + DG G++ L++++ Sbjct 239 EYLFGVKVKDLMVRDLITVSPSLSLEEVVNGYFLKYGYGGFPVVE-DGKYLGIITLKEIK 297 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 + + T V ++ L +E LE M R +V +G+ + G++T Sbjct 298 GIPKNAFEDTRVREVYLKHKKQWEISAEEEAIKALESMLR-EDTGRLVVKKGAFIQGLIT 356 Query 360 PSDVARLIDV 369 + +AR + + Sbjct 357 RNGIARYVQI 366 >gi|332702988|ref|ZP_08423076.1| peptidase M50 [Desulfovibrio africanus str. Walvis Bay] gi|332553137|gb|EGJ50181.1| peptidase M50 [Desulfovibrio africanus str. Walvis Bay] Length=375 Score = 201 bits (512), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 131/366 (36%), Positives = 193/366 (53%), Gaps = 3/366 (0%) Query 5 IPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLASL 63 I L + GF V++ S ++I+ L TWSLA P YW + A GA+ L AS+ Sbjct 6 IKLFTLFGFEVSIDASWIIIVVLVTWSLAVGFFPSYYPRLDVPTYWAMAAVGALGLFASI 65 Query 64 LAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATF 123 + HE H+VVARR G+ + +TL+LFGGV+ + E ++ + +A AGP +S+ L F Sbjct 66 IFHEFWHSVVARRMGLPMRGITLFLFGGVSEMTEEPRSARTELWMAAAGPFSSILLGFAF 125 Query 124 GALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSVR 183 + V PA V+ V +LA +N +L FNLLP PLDGGR++R+ LWR D Sbjct 126 WGVYRWGDSVGWPAPVLGVTAYLAFINFILAAFNLLPAFPLDGGRIIRSLLWRWKKDLTW 185 Query 184 AGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLFA 243 A AA G ++ +LI LGL +AG LVGG+W IG F+ +AA+ ++ +Q Sbjct 186 ATRIAASLGAIIGAILIGLGLLNMLAGALVGGLWYLVIGIFLRSAAQSSYRQVVVRQRLQ 245 Query 244 GVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAP 303 G RV D M P T + + +F++ ++ H YPV D +G + G V ++ +R V Sbjct 246 GERVRDLMVRDPVTVAPDLLLTEFVEDFIYKHHHDMYPVLD-NGRLVGAVRIKDVRTVPR 304 Query 304 SRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDV 363 R V D+ P + P L L+RM G SR LV E + G++T DV Sbjct 305 EERGWRKVADVLSPFTAELVLPPDMDLGEALDRMTTSG-NSRFLVVEEGRLAGLITLKDV 363 Query 364 ARLIDV 369 + + V Sbjct 364 STAVSV 369 >gi|269836755|ref|YP_003318983.1| CBS domain-containing protein [Sphaerobacter thermophilus DSM 20745] gi|269786018|gb|ACZ38161.1| CBS domain containing protein [Sphaerobacter thermophilus DSM 20745] Length=393 Score = 201 bits (512), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 133/377 (36%), Positives = 203/377 (54%), Gaps = 7/377 (1%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVML 59 M +I LGR+ G V+ +H++ L++ L T+SLA P + YWL GA ++L Sbjct 1 MEASIRLGRVRGIVIGIHYTWLIVFGLLTYSLAVGFFPSLYEAWSTTRYWLAGALATILL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 AS+LAHEL HA+VA+ G+ V S+TL++FGGV L E++T FRIA AGPA SL + Sbjct 61 FASVLAHELGHALVAQSRGIPVRSITLFIFGGVAQLSQESETAGDEFRIAIAGPAVSLVI 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 AL + GV T A ++ ++L N++L FNL+PG PLDGGR+ RA +W Sbjct 121 GLGSLALWWLVRGVNTFA--AAILFYLGVANVILVAFNLIPGFPLDGGRVFRAIVWGITN 178 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 RA AA G ++ + I G+ +V + G+WL IGWF+ +AA + ++ + Sbjct 179 SLERATKIAATVGVIIGYLFIVAGIF-YVFASPIQGIWLIAIGWFLQSAAEQSYRQMRLE 237 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 + F+GVRV M P + ++D + RYVL PV D +G + G++ L LR Sbjct 238 RAFSGVRVGTIMDPNPVVVRPEVTLDDLVDRYVLARNVRGLPVVD-NGYLVGIITLTDLR 296 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 ++ +V + P + T P LT L+ ++ + V EG+ +VG++T Sbjct 297 EIPREDWGHITVRERMTPRQELITLGPDSELTDALKALSA-KDIHQIPVIEGNTLVGLLT 355 Query 360 PSDVARLIDVYRLAQPE 376 S V R + + R PE Sbjct 356 RSAVIRYMQL-RDELPE 371 >gi|57234442|ref|YP_181501.1| protease family protein [Dehalococcoides ethenogenes 195] gi|57224890|gb|AAW39947.1| protease family protein [Dehalococcoides ethenogenes 195] Length=380 Score = 201 bits (511), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 131/392 (34%), Positives = 205/392 (53%), Gaps = 33/392 (8%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAV-------VYWLLGA 53 M+ + LGRI G + +H S L+I L +WSLA V YPA+ W+LG Sbjct 1 MKSSFKLGRILGIEIGIHVSWLIIFALLSWSLA------VAYYPAIDENISPLTAWVLGI 54 Query 54 GGAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGP 113 ++L S+LAHEL H++VA R G+ V+S+TL++FGGV+ L E P A FR+A +GP Sbjct 55 TSCLLLFGSVLAHELGHSIVAIRHGIPVKSITLFIFGGVSNLTKEPDNPGAEFRMAISGP 114 Query 114 ATSL-------ALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDG 166 A S+ A A F AL TLA V +LA +N +L +FNL+PG PLDG Sbjct 115 AVSIILALVFWAFEAVFSALDATLAS--------GVFLYLAQINAMLAIFNLIPGFPLDG 166 Query 167 GRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIF 226 GR++RA +W +A AAR G A +LI G+A G + G+WLA IGWF+ Sbjct 167 GRVLRAIIWNASNSIKKATRIAARVGLGFAYLLIFGGIAIAFLGIGISGLWLALIGWFMA 226 Query 227 AAAREEETRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRD 286 AA+ + ++ + V V+ M + T + + Y+L A PV + + Sbjct 227 TAAQGSYQQTVISEILSAVNVSRVMRREFKTIDPDKTLYQTLHEYILPLNQRALPVFE-N 285 Query 287 GSITGLVALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRA 346 G +TGL++L ++ + + T V + PL + T P+E L++++ + Sbjct 286 GQLTGLISLSDIKKIPTDKLGQTYVRQVMTPLEKLQTVAPEENLSSVVNMLQSKDINQLP 345 Query 347 LVTEGSAVVGIVTPSDVARLIDVYRLAQPEPT 378 ++++G +VGI++ + LI+ ++ Q T Sbjct 346 VLSDGK-LVGIISRTS---LIEYLQMRQEMET 373 >gi|300087970|ref|YP_003758492.1| peptidase M50 [Dehalogenimonas lykanthroporepellens BL-DC-9] gi|299527703|gb|ADJ26171.1| peptidase M50 [Dehalogenimonas lykanthroporepellens BL-DC-9] Length=372 Score = 200 bits (508), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 133/376 (36%), Positives = 203/376 (54%), Gaps = 15/376 (3%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGT--VGGYPAVVYWLLGAGGAV 57 M+ + LGRI G + +H+S IL +WSLA P + G YW+LG ++ Sbjct 1 MKASFVLGRIFGIEIRIHYSWFFILIFLSWSLAVAYFPQSDITSGLSVTSYWILGIVASL 60 Query 58 MLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSL 117 L S+LAHEL H++VARR G+ V ++TL+LFGG + EA++ A FR+A GP S Sbjct 61 SLFLSVLAHELGHSIVARRNGIPVSNITLFLFGGSANITREAQSSGAEFRMAVTGPMVSF 120 Query 118 ALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRR 177 L+ F + L GV + ++ +LA VNL+LG+FNLLPG PLDGGR+ +A +W+ Sbjct 121 GLAGLFFTIYAGLGGVSGG--LTAIMLYLAQVNLILGIFNLLPGFPLDGGRVFKAIVWQL 178 Query 178 HGDSVRAGIGAARAGRVVALVLIALGLA-EFVAGGLVGGVWLAFIGWFIFAAAREEETRI 236 + +A AA +G+V+A ++I G+A FV G + G+WLA IGWF+ +AA + Sbjct 179 TKNEKQATRIAASSGQVMAYMMIFGGVALAFVVG--ISGLWLALIGWFLASAATASYQQT 236 Query 237 STQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHS--AYPVADRDGSITGLVA 294 ++ +GVRV D I+ E Q RHS A PV G + GL+ Sbjct 237 IVSEVISGVRVRDVANQAVINVGPEISGE---QALAAMSRHSQRALPVVI-GGRLVGLIT 292 Query 295 LRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAV 354 L L+ ++ S+ +V I PL + T P + ++ L+ + G ++ EG V Sbjct 293 LADLKHISLHDGSSVTVEQIMTPLEKLSTLNPDDDMSKALQILTESGYNQLPVIEEGR-V 351 Query 355 VGIVTPSDVARLIDVY 370 G++T SD+ I ++ Sbjct 352 SGLLTRSDIINFIQIH 367 >gi|270308082|ref|YP_003330140.1| protease [Dehalococcoides sp. VS] gi|270153974|gb|ACZ61812.1| protease [Dehalococcoides sp. VS] Length=380 Score = 199 bits (506), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 126/385 (33%), Positives = 205/385 (54%), Gaps = 19/385 (4%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAV-------VYWLLGA 53 M+ + LG+I G + +H S L+I L +WSLA V YPA+ W+LG Sbjct 1 MKSSFKLGQILGIEIGIHVSWLIIFALLSWSLA------VAYYPAIDENISPLTAWVLGI 54 Query 54 GGAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGP 113 ++L S+LAHEL H++VA R G+ V+S+TL++FGGV+ L E P A FR+A +GP Sbjct 55 TSCLLLFGSVLAHELGHSIVAIRHGIPVKSITLFIFGGVSNLTKEPDNPGAEFRMAISGP 114 Query 114 ATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAY 173 A S+ L+ F A + + +V V +LA +N +L +FNL+PG PLDGGR++RA Sbjct 115 AVSIILALVFWAFQAAFSALDA-TLVSGVFLYLAQINAMLAIFNLIPGFPLDGGRVLRAI 173 Query 174 LWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEE 233 +W +A AAR G A +LI G+A G + G+WLA IGWF+ AA+ Sbjct 174 IWNASNSIKKATRIAARVGLGFAYLLIFGGIAIAFLGIGISGLWLALIGWFMATAAQGSY 233 Query 234 TRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLV 293 + ++ + V V+ M + T + + Y+L A PV + +G +TGL+ Sbjct 234 QQTVISEILSAVNVSRVMRREFKTIDPDKTLYQTLHEYILPLNQRALPVFE-NGQLTGLI 292 Query 294 ALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSA 353 +L ++ + + T V + PL + T P+E L++++ + ++++G Sbjct 293 SLSDIKRIPTDKLGQTYVRQVMTPLEKLQTVAPEENLSSVVNMLQSKDINQLPVLSDGK- 351 Query 354 VVGIVTPSDVARLIDVYRLAQPEPT 378 +VGI++ + LI+ ++ Q T Sbjct 352 LVGIISRTS---LIEYLQMRQEMET 373 >gi|206889277|ref|YP_002248414.1| peptidase, M50 family protein [Thermodesulfovibrio yellowstonii DSM 11347] gi|206741215|gb|ACI20272.1| peptidase, M50 family protein [Thermodesulfovibrio yellowstonii DSM 11347] Length=376 Score = 198 bits (504), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 115/367 (32%), Positives = 198/367 (54%), Gaps = 8/367 (2%) Query 7 LGRIAGFVVNVHWSVLVILWLFTWSLATM-LPGTVGGYPAVVYWLLGAGGAVMLLASLLA 65 +G++ G + +H++ L++ L TWSL+T P P YW+ G A +L S+ Sbjct 11 IGKVFGIPIRIHYTWLIVFGLITWSLSTFYFPKVAPQLPVASYWINGVVAAFLLFFSVAI 70 Query 66 HELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGA 125 HELAH++VA+R +++ES+TL++FGGV + GE + KA FRIA AGP TS L+A F Sbjct 71 HELAHSLVAKRYKLTIESITLFIFGGVAQMKGEPPSAKAEFRIAIAGPLTSFFLAAFFFL 130 Query 126 LAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSVRAG 185 ++ + S+ ++ +NL+LG FNL+PG P+DGGR++RAYLW + D + A Sbjct 131 FSLKTTNIGFK----SLFSYVYQLNLILGFFNLIPGFPMDGGRVLRAYLWSKKKDYLYAT 186 Query 186 IGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLFAGV 245 A++ G+ +A+ + G+ G+ G+WL IGWF+++AA + + + L V Sbjct 187 QKASKIGQNIAIFFMIFGVFSLFM-GIPTGLWLILIGWFLYSAAYGSYQQSTLEALLHNV 245 Query 246 RVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAPSR 305 +V D M T +++++ I Y L ++ +PV +G G++ALR ++ + Sbjct 246 KVKDLMVKDLVTVSPSMSIQEVINNYFLKYGYTGFPVIS-EGKYLGILALRDIKSIPEED 304 Query 306 RSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVAR 365 R V + PQ+ LE+M R ++ E + G++T + +AR Sbjct 305 RPLREVSEFYGRHKPQWEISPQDNALNALEKMLR-EDVGRLVILEDGKITGMITRNGIAR 363 Query 366 LIDVYRL 372 +++ + Sbjct 364 YLEIKKF 370 >gi|134099210|ref|YP_001104871.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] gi|133911833|emb|CAM01946.1| peptidase M50 [Saccharopolyspora erythraea NRRL 2338] Length=400 Score = 197 bits (502), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 155/368 (43%), Positives = 210/368 (58%), Gaps = 3/368 (0%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVML 59 M IP GRIAG V +HWSV I+ + LA LP G+ + Y + G + +L Sbjct 1 MHGTIPPGRIAGVRVGLHWSVAGIVVVVAAGLAAYQLPAVYPGHSRIAYAVAGVAASGLL 60 Query 60 LASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLAL 119 + SLL HELAHAVVARR GV+VE +TLWL GGV L EA++P A RIA GP S AL Sbjct 61 VCSLLGHELAHAVVARRNGVAVEGITLWLLGGVARLRDEARSPGADLRIATVGPTASAAL 120 Query 120 SATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHG 179 + FGALA T +VI+V +LA +N+LL LFNLLP APLDGGR++RA LWR G Sbjct 121 AVAFGALAWTSNLAGAGELVIAVLGYLALLNVLLALFNLLPAAPLDGGRVLRAALWRWRG 180 Query 180 DSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQ 239 D RA + +ARAG ++ +L+ G+ + V GG+W +G FI AAA EE R Sbjct 181 DRHRAALWSARAGLGLSYLLVIGGIVQLVIQS-TGGLWWVLLGMFIAAAAIAEERRARAS 239 Query 240 QLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLR 299 AG+RV D M+ + VE F++ H+ PV G + G++ +R + Sbjct 240 AALAGIRVRDVMSPHVDAVDADLTVEQFLRADATPGGHAVRPVLGPAGRVEGVITVRDVN 299 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 + R T+++ D+A PL + TA P+E LTALL R+ LV +GIV+ Sbjct 300 AIPEQERPTSTLSDVAWPLERIATAAPEEALTALLPRLDEAA-EGHVLVFAEHDRLGIVS 358 Query 360 PSDVARLI 367 PSD++R + Sbjct 359 PSDISRTV 366 >gi|116749915|ref|YP_846602.1| peptidase M50 [Syntrophobacter fumaroxidans MPOB] gi|116698979|gb|ABK18167.1| peptidase M50 [Syntrophobacter fumaroxidans MPOB] Length=383 Score = 193 bits (491), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 112/366 (31%), Positives = 190/366 (52%), Gaps = 3/366 (0%) Query 5 IPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLASL 63 I L R+ G +++ +S VI L WSL+ P A YW G ++ S+ Sbjct 14 INLFRVGGIRISIDFSWFVIFVLILWSLSVGYFPREFPAQNAYSYWGAGIVATLLFFLSV 73 Query 64 LAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATF 123 + HELAH+++A R+G+ + +TL++FGG++ L +AK F+IA GP +S L+ F Sbjct 74 IFHELAHSLIAIRSGLQIPEITLFIFGGISKLSEDAKDAADEFKIAVVGPLSSFVLAVVF 133 Query 124 GALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSVR 183 L ++ P + + +L +N L +FNL+PG PLDGGR++RA+LW + G Sbjct 134 MFLEKAARSMQLPMTAV-IFGYLTWINFALAVFNLIPGFPLDGGRILRAFLWWKTGSLTN 192 Query 184 AGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLFA 243 A A+ G+ +A+ ++ LG + G L+GG+WL FIG F+ A + +Q Sbjct 193 ATKYASDVGKGLAVAMMILGGIQIFGGMLIGGLWLIFIGAFLRGVAEGSYQEVLMRQSLE 252 Query 244 GVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAP 303 GV+V + M + P + V I Y+L + YPV +R G G+V + ++D+ Sbjct 253 GVKVDEVMVREVIGVPPDLPVSRLISAYLLRYGYKGYPVMERAGEPIGIVEIFHIKDIHE 312 Query 304 SRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDV 363 R + +V ++ P++ P PL L+++ R LV + +VG++T S + Sbjct 313 EDRQSRTVAEVMEPINPDLVVEPDLPLIDALKKIGD-SDLGRLLVIQDKQMVGLITKSGL 371 Query 364 ARLIDV 369 R +++ Sbjct 372 NRFLEI 377 >gi|254467670|ref|ZP_05081078.1| peptidase, M50 family protein [Rhodobacterales bacterium Y4I] gi|206684244|gb|EDZ44729.1| peptidase, M50 family protein [Rhodobacterales bacterium Y4I] Length=383 Score = 192 bits (489), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 137/375 (37%), Positives = 196/375 (53%), Gaps = 7/375 (1%) Query 3 DAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLA 61 +A+ + R+ GF + V S L+I L TWSLAT P + G VY +L + A Sbjct 4 NAVRIARLQGFDIKVDPSWLLIAALITWSLATQFFPMSYPGAGQAVYLMLAVLAMLGFFA 63 Query 62 SLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSA 121 SL+ HE++H+VVARR GV ++ +TL++FGGV LG E KT + F IA AGP S AL+ Sbjct 64 SLILHEMSHSVVARRFGVEIKGITLFIFGGVAELGSEPKTAVSEFWIAIAGPLMSFALAF 123 Query 122 TFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDS 181 F LA + + V +LA +NL+L +FNL+P PLDGGR++RA+LW R D Sbjct 124 GFWLLAQIGWALAPGGALNPVLGYLALINLVLAVFNLVPAFPLDGGRILRAWLWSRSRDL 183 Query 182 VRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQL 241 + A A R A LI GL +G V +W IG F+ +AA+ Sbjct 184 LAATRTATRISSYFAYALIFYGLIGLFSGNPVAALWQVLIGVFVLSAAKGTYAHQLQTAA 243 Query 242 FAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDV 301 F G VAD MT P TA I+++ + +L ER S PV + G + G + L V Sbjct 244 FKGKTVADLMTRDPVTAGPEISLQALAHQVLLPERKSFVPVV-QQGVLLGCTDTQDLARV 302 Query 302 APSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPS 361 R + T V D+ P + P AL+ +++ G R + LVTE ++G++T + Sbjct 303 PQERWAQTPVDDVYQPPDGSNSVAPDMQADALMRKISETG-RRKFLVTEQGRLLGVITLT 361 Query 362 D----VARLIDVYRL 372 D +A L +V RL Sbjct 362 DLTGYIALLQEVRRL 376 >gi|298528325|ref|ZP_07015729.1| peptidase M50 [Desulfonatronospira thiodismutans ASO3-1] gi|298511977|gb|EFI35879.1| peptidase M50 [Desulfonatronospira thiodismutans ASO3-1] Length=380 Score = 191 bits (485), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 119/362 (33%), Positives = 187/362 (52%), Gaps = 4/362 (1%) Query 3 DAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLA 61 ++ L +I GF + V S L+I L TWSLA P + + YW+LG GA+ L Sbjct 4 KSLNLFKIFGFQIKVDVSWLIIAVLVTWSLAVGFFPHFIEDLSPMGYWILGVIGALGLFF 63 Query 62 SLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSA 121 S+L HE H+ VAR GV + +TL++FGGV + + ++PK+ F IA AGP S+ L+ Sbjct 64 SILFHEFWHSWVARNYGVPIRGITLFIFGGVAEMEDDPQSPKSEFWIAIAGPLASIFLAL 123 Query 122 TFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDS 181 F L + A I + +LA +N +L +FNL+P P+DGGR++RA LW+ GD Sbjct 124 VFFVLYNAAQFMELGAAGIILFMYLALINTILAVFNLIPAFPMDGGRILRAVLWKWKGDQ 183 Query 182 VRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQL 241 A AA G + LVLI +G+ + G +VGG+W IG FI A+ ++ + Sbjct 184 RWATRIAANMGSMFGLVLIGIGILNMLTGNVVGGLWYFVIGIFIRYVAQNAYRQMMIKSA 243 Query 242 FAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDV 301 AG RV M + +P I + ++ Y+ +PV D+ G + G + RQ+ + Sbjct 244 VAGARVRSLMKRPVYVSPD-ITLARLVEEYIYQFHFKMFPVVDQ-GKLLGCITTRQIGSI 301 Query 302 APSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPS 361 + T V + +P T P + L RM G +SR +V + ++G+++ Sbjct 302 DRHQWGDTLVRHVYIPCSDNNTIHPNTDILYALNRMNQEG-QSRMMVVDNGILMGMISLK 360 Query 362 DV 363 D+ Sbjct 361 DI 362 >gi|85860795|ref|YP_462997.1| M50 family membrane endopeptidase [Syntrophus aciditrophicus SB] gi|85723886|gb|ABC78829.1| membrane endopeptidase, M50 family [Syntrophus aciditrophicus SB] Length=377 Score = 189 bits (480), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 123/368 (34%), Positives = 192/368 (53%), Gaps = 4/368 (1%) Query 3 DAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLA 61 + I L ++ GF V + S L++ L TWSLA + PG+ + YW +G GA+ L Sbjct 4 NRITLFKLLGFEVRIDASWLLLALLVTWSLAKGVFPGSYKAAEST-YWAMGVFGALGLFL 62 Query 62 SLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSA 121 S++ HEL H++VA R G+ ++ +TL++FGGV + E + KA F +A AGP +SLAL Sbjct 63 SIIFHELCHSLVATRYGIPMKGITLFIFGGVAEMDDEPPSAKAEFLMAIAGPLSSLALGL 122 Query 122 TFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDS 181 TF + + P + +V +L +N +L FNLLP PLDGGR++R+ LW G+ Sbjct 123 TFHGVTYAGRNLGWPGSISTVTSYLGLINFVLAGFNLLPAFPLDGGRVLRSMLWGWKGNL 182 Query 182 VRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQL 241 A ++ G ++LI +G+ G +GG+W IG F+ AA+ T++ +++ Sbjct 183 RWATRISSSIGSTFGILLIVMGIFGLFRGNFIGGLWWLMIGLFLRNAAQMSYTQVLARKV 242 Query 242 FAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDV 301 G +V M P T + +E+F+ YV +PV D + G + +RQ +V Sbjct 243 LEGEKVRRFMVPDPITVSRALTLEEFVNDYVYRYHFKMFPVVSFD-RLVGCITVRQAAEV 301 Query 302 APSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPS 361 +VG+IA T P E L +M+ SR LV EG +VGIVT Sbjct 302 PREEWREHTVGEIAGACTPDITVGPDEDAVRALAKMSRT-TNSRLLVVEGDRLVGIVTLK 360 Query 362 DVARLIDV 369 D+ R + + Sbjct 361 DMLRFLSL 368 >gi|225849662|ref|YP_002729896.1| zinc metalloprotease Sll0528 [Persephonella marina EX-H1] gi|225645889|gb|ACO04075.1| putative zinc metalloprotease Sll0528 [Persephonella marina EX-H1] Length=367 Score = 189 bits (479), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 120/364 (33%), Positives = 189/364 (52%), Gaps = 14/364 (3%) Query 3 DAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLA 61 + IPL ++ G +N+ +S I +L T++LA P GY +VYW++G+ AV+L Sbjct 2 NPIPLFKVFGIQINLDFSWFFIFFLVTFTLAEGFFPHFYPGYSFIVYWIVGSISAVLLFV 61 Query 62 SLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSA 121 S+L HEL+H+V A G+ V+S+ L++FGGV + EA PK F +A AGP S L Sbjct 62 SVLLHELSHSVTALHFGIPVKSINLFIFGGVAMIEEEAPNPKVEFLVAAAGPLCSFTL-- 119 Query 122 TFGALAITLAGVR-TPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD 180 G L T+A ++ + +L VN LGLFNL+P PLDGGR++RA +W + D Sbjct 120 --GILFFTMAYFYPVDDLLNGIINYLMYVNFALGLFNLVPAFPLDGGRILRAIIWTKK-D 176 Query 181 SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ 240 + A ++ +G + A L+ +G+ + G + G+W IG F+ A++ + Sbjct 177 LLTATRISSLSGTIFAYFLMFVGVISILQGNFINGMWYGLIGLFLRQASKTSYEQTKFSV 236 Query 241 LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD 300 + +G +V + M P V DFI Y R S YPV RDG I ++ + +++ Sbjct 237 ILSGYKVENFMQTVKPLLPDE-TVLDFINFYYPFYRSSIYPVIGRDGQIY-VINIEDIKN 294 Query 301 VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRAL-VTEGSAVVGIVT 359 + R S V DIA PL + P + L L+ M R + V G+ ++GI+ Sbjct 295 IPEERWSVVHVIDIAKPL--IAYVSPYDSLYKALKLMNKY--RLEEIPVVYGNTILGILR 350 Query 360 PSDV 363 S + Sbjct 351 KSSI 354 >gi|73748579|ref|YP_307818.1| M50 family metallopeptidase [Dehalococcoides sp. CBDB1] gi|289432605|ref|YP_003462478.1| peptidase M50 [Dehalococcoides sp. GT] gi|73660295|emb|CAI82902.1| metallopeptidase, M50 family [Dehalococcoides sp. CBDB1] gi|288946325|gb|ADC74022.1| peptidase M50 [Dehalococcoides sp. GT] Length=379 Score = 189 bits (479), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 121/385 (32%), Positives = 200/385 (52%), Gaps = 20/385 (5%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAV-------VYWLLGA 53 M+ + LGRI G + +H S +I L +WSL +V YP++ W LG Sbjct 1 MKSSFKLGRILGIEIGIHASWFIIFALLSWSL------SVAYYPSIDENISPFTGWTLGI 54 Query 54 GGAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGP 113 +++L S+LAHEL H+ +A R G+ V+S+ L++FGGV+ L E P A FR+A +GP Sbjct 55 LSSLLLFGSVLAHELGHSFIAIRQGIPVKSIDLFIFGGVSNLTKEPDNPAAEFRMAISGP 114 Query 114 ATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAY 173 A S+ L+ F I + A + V +LA +N +L +FNL+PG PLDGGR++RA Sbjct 115 AVSIVLALVFWVFQIVFSS--QNATLAGVFLYLAQINAMLAIFNLIPGFPLDGGRVLRAI 172 Query 174 LWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEE 233 +W D RA +A G A +LI G+A G + G+WLA IGWF+ +AA+ Sbjct 173 IWNASNDIRRATRISAGVGLGFAYLLIFGGIAAAFLGIGISGLWLALIGWFLASAAQGSF 232 Query 234 TRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLV 293 + ++ V ++ M + T + + Y+L A PV + +G + GL+ Sbjct 233 QQTVISEILREVNISRVMKREFKTIEPDNTLYQALHEYILPLNQRALPVFE-NGKLAGLI 291 Query 294 ALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSA 353 +L ++ + ++ + TSV P + T P+E L +L + +++EG Sbjct 292 SLSDIKKIPTNQLNQTSVRQAMTPFEKLRTVGPEEHLGNVLNLLQSEDINQLPVLSEGK- 350 Query 354 VVGIVTPSDVARLIDVYRLAQPEPT 378 ++G+++ +D LI+ ++ Q T Sbjct 351 LIGLISRTD---LIEYLQMRQEIET 372 >gi|21227420|ref|NP_633342.1| hypothetical protein MM_1318 [Methanosarcina mazei Go1] gi|20905786|gb|AAM31014.1| conserved protein [Methanosarcina mazei Go1] Length=364 Score = 187 bits (476), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 122/381 (33%), Positives = 208/381 (55%), Gaps = 32/381 (8%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGY---PAVVYWLLGAGGAV 57 M+ ++ +G + G + +H + L+IL +F + A + P G PA ++L + A+ Sbjct 1 MKSSLKIGSVLGIPIKLHITFLLILPVFAYIFA-INPYPYGFQEVEPASTKYMLSSLTAI 59 Query 58 MLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSL 117 +L AS+L HELAH+ +A++ GV++ES+TL+LFGGV+++ + P ++AFAGP TSL Sbjct 60 LLFASILLHELAHSYLAKQYGVNIESITLFLFGGVSSMEEIPRDPGQEAKMAFAGPFTSL 119 Query 118 ALSATFGALAITLAG---VRTPAI----VISVAWWLATVNLLLGLFNLLPGAPLDGGRLV 170 + G++ + L + PA+ V W L +NL+LG+FNLLP P+DGGR++ Sbjct 120 VI----GSICLLLYRYIILSNPALSENPVYLTIWILGAMNLVLGIFNLLPAFPMDGGRVL 175 Query 171 RAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAR 230 R++ RR V+A AA G+ A+++ G+ L+G +W I FI+A A Sbjct 176 RSFYARRMS-YVKATKSAAAVGKFFAILMAIFGI-------LIGNLWFPLIALFIYAGAS 227 Query 231 EEETRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSIT 290 EEE + V D MT + + P +NVED IQ ++ ++H YPV + G++ Sbjct 228 EEERSTQASVSLENILVKDIMTKEVVSVPPSMNVEDLIQ-FMFEKKHMGYPVVE-SGNLK 285 Query 291 GLVALRQLRDVAPSRRSTTSVGDIAL-PLHSVPT-ARPQEPLTALLERMAPLGPRSRALV 348 G+V ++ V R V DI + SVP+ A+ + L + + R LV Sbjct 286 GIVTFTDIQRVPTIDRPVMRVSDIMTRDIISVPSDAQASDVLKLVTSKNI-----GRVLV 340 Query 349 TEGSAVVGIVTPSDVARLIDV 369 + ++VG+++ +D+ R++ + Sbjct 341 IDNGSLVGVLSRTDLVRILKL 361 >gi|332710745|ref|ZP_08430686.1| Zn-dependent protease [Lyngbya majuscula 3L] gi|332350522|gb|EGJ30121.1| Zn-dependent protease [Lyngbya majuscula 3L] Length=403 Score = 187 bits (475), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 110/343 (33%), Positives = 179/343 (53%), Gaps = 6/343 (1%) Query 26 WLFTWSLATMLPGTV--GGYPAVVYWLLGAGGAVMLLASLLAHELAHAVVARRAGVSVES 83 W F L TM+ +++ W+ G A++L +S+L HEL H++ A G+ V S Sbjct 21 WFFILLLVTMINAREFDSSLGSILAWVAGLAMALLLFSSVLLHELGHSLAALSQGIKVNS 80 Query 84 VTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGALAITLAGVRTPAIVISVA 143 +TL++FGG+ ++ E+KTP AF++A AGP S L F L +TL T A ++A Sbjct 81 ITLFIFGGIASIDRESKTPGEAFQVAIAGPLVSFILFGLFYVLTLTLP---TSAWAYTIA 137 Query 144 WWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALG 203 +A +NL+L LFNL+PG PLDGG++++A +W+ GD AAR G+ L+ ++LG Sbjct 138 NEIARINLVLALFNLIPGLPLDGGQVLKAAVWKLTGDLFTGVRWAARTGKGFGLIALSLG 197 Query 204 LAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQLFAGVRVADAMTAQPHTAPGWIN 263 L + G + +W IGWFIF A + + Q++ + ++AMT Sbjct 198 LGMTLLTGTLAFIWPTLIGWFIFRNASAYDQLTTLQEVLLKLMASNAMTRDFRVVEANQT 257 Query 264 VEDFIQRYVLGERHSAYP-VADRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHSVP 322 + F Y+L +R + P A +G GLV + L V SR T ++ I PL +P Sbjct 258 LRSFADEYILTDRQNPMPYYAATNGRYRGLVKIEDLHFVERSRWDTETLETIVRPLSEIP 317 Query 323 TARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVAR 365 T + PL ++ + L + ++++ V G++ D+ R Sbjct 318 TVEEKTPLVEVINSLEELNIKRVSVLSPAETVAGVIDRGDIVR 360 >gi|254410553|ref|ZP_05024332.1| peptidase, M50 family protein [Microcoleus chthonoplastes PCC 7420] gi|196182759|gb|EDX77744.1| peptidase, M50 family protein [Microcoleus chthonoplastes PCC 7420] Length=373 Score = 187 bits (474), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 118/379 (32%), Positives = 205/379 (55%), Gaps = 11/379 (2%) Query 1 MRDAIPLGRIAG--FVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVM 58 M +I +G + G F VN W ++L L T+ L G G ++ W+LG GA++ Sbjct 1 MNGSIRVGNLLGIPFYVNPSW--FLVLALVTFEFGGYL-GGFAGLTGILPWVLGFVGALL 57 Query 59 LLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLA 118 L AS+LAHEL H++VA R G+ V+S+TL+LFGG+ +L E++TP AF +A AGP SLA Sbjct 58 LFASVLAHELGHSLVAIRQGIEVKSITLFLFGGLASLEKESQTPADAFWVAIAGPLVSLA 117 Query 119 LSATFGALAITLAGVRTP-AIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRR 177 L A F + ++ +GV P A ++S+ LA++NL+L LFNL+PG PLDGG ++++ +W+ Sbjct 118 LFALFTGIGVS-SGVSGPLAAILSL---LASINLVLALFNLIPGLPLDGGNILKSVVWKI 173 Query 178 HGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRIS 237 G+ R + A+R G+VV + I++G+ + G +W IG F+ A + Sbjct 174 TGNPYRGVVFASRVGQVVGWMGISIGILSVLGLSNFGSIWTLLIGVFLLQNAGMSAQSAT 233 Query 238 TQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERH-SAYPVADRDGSITGLVALR 296 Q+ ++ DA+ + +++ DF Y++G++ + V D G + G +A+ Sbjct 234 LQEKLQDLKAEDAVIPESPIISADLSLRDFANNYIIGKKEWRKFLVTDEQGQLIGAIAVD 293 Query 297 QLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVG 356 L+ + S +TT V ++ P+ + + L ++ + +V E +VG Sbjct 294 DLKTIPTSNWTTTPVSELIQPVDLDAIVKSDQSLLEVITLLEQGKFTQLPVVRENGVLVG 353 Query 357 IVTPSDVARLIDVYRLAQP 375 ++ + + L++ P Sbjct 354 LLEKASIVSLLEKRTQTNP 372 >gi|188586364|ref|YP_001917909.1| peptidase M50 [Natranaerobius thermophilus JW/NM-WN-LF] gi|179351051|gb|ACB85321.1| peptidase M50 [Natranaerobius thermophilus JW/NM-WN-LF] Length=370 Score = 186 bits (471), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 111/376 (30%), Positives = 194/376 (52%), Gaps = 12/376 (3%) Query 3 DAIPLGRIAGFVVNVHWSVLVILWLFTWSLAT-MLPGTVGGYPAVVYWLLGAGGAVMLLA 61 +++ + R G V + +S LVI +F++SL+T P + ++YWL G +ML Sbjct 4 NSLRIARFFGIDVELDFSWLVIFMVFSFSLSTNYFPNVLAEKTDLIYWLAGVTATIMLFI 63 Query 62 SLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSA 121 S+L HE AH++ A + G ++ +TL++FGGV L E +T + +I GP +SLAL+A Sbjct 64 SVLIHEFAHSLTALKEGHDIKKITLFIFGGVAQLDEEPRTSVSELKITIVGPVSSLALAA 123 Query 122 TFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGDS 181 FG +++ + + ++LA VNL +G+ NL+P PLDGGR++RA +W D Sbjct 124 IFGPISLLFT---EGHFLGEILFFLARVNLTIGILNLIPAFPLDGGRILRAAIWYFKKDL 180 Query 182 VRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQL 241 + A + AG +A +L+ +G V V G+W F+GW ++ A + T+++ + Sbjct 181 LLATKISVLAGSALAFLLMGMGFMITVTVS-VMGLWYIFMGWLLYQAGQNSYTQVTLKNT 239 Query 242 FAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHS--AYPVADRDGSITGLVALRQLR 299 +G +V D MT + ++ ++ + RH A+PV ++ GLV + Q++ Sbjct 240 LSGYQVQDVMTDNVLVVSTELTIDRLVEEFY---RHKVGAFPVVG-GSAVLGLVTMNQVK 295 Query 300 DVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVT 359 V V +I + P+E + +MA R LV + +VGI++ Sbjct 296 TVNQDEWEVKKVREIMTAIDECIIMEPEEEAVEAMMKMARHNA-GRVLVMDAGRLVGILS 354 Query 360 PSDVARLIDVYRLAQP 375 +D+ RLI + L + Sbjct 355 NTDMMRLIKMKTLFEK 370 >gi|334120955|ref|ZP_08495031.1| peptidase M50 [Microcoleus vaginatus FGP-2] gi|333455674|gb|EGK84317.1| peptidase M50 [Microcoleus vaginatus FGP-2] Length=367 Score = 185 bits (470), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 126/385 (33%), Positives = 204/385 (53%), Gaps = 27/385 (7%) Query 1 MRDAIPLGRIAG--FVVNVHWSVLVILWLFTW----SLATMLPGTVGGYPAVVYWLLGAG 54 M +G + G F VN W ++L L TW +LA + P T+G V W+LG Sbjct 1 MNGTFRVGNLFGIPFFVNASW--FLVLGLVTWQYGGALAALFP-TLG---PVAPWMLGLF 54 Query 55 GAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPA 114 A++L AS+LAHEL H+ VA + G+ V+S++L+LFGG+ L E+KTP AF +A AGP Sbjct 55 TALLLFASVLAHELGHSWVAIKQGIGVKSISLFLFGGLANLERESKTPAEAFWVAIAGPL 114 Query 115 TSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYL 174 SL LS A+ I AG+ PA ++ LA++NL+L LFNL+PG PLDGG +++A + Sbjct 115 VSLFLSGLLTAIGIG-AGLTGPA--AAIVGLLASINLVLALFNLIPGLPLDGGNILKAIV 171 Query 175 WRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEET 234 W+ G+ + I A+R G+++ + IA G+ G +W IGWF+ A + Sbjct 172 WKITGNPYKGVIFASRVGQIIGWIAIAT--------GVFGNIWNLVIGWFLLQNAGQSAQ 223 Query 235 RISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHS--AYPVADRDGSITGL 292 + Q AG+ ADA+T + +++ +F YV+G + + D G + G Sbjct 224 YATVQNKLAGLTAADAVTPESPIVSQDLSLREFANNYVIGSTQTWRRFLATDDAGQLVGA 283 Query 293 VALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGS 352 + L L+ + V ++ P+ T +P+ L ++ + L + ++ E Sbjct 284 IDLDDLKTIPTGTWPQVLVKELLKPIEFSTTVKPELSLLEVVTLLEQLKVQELPVIRENG 343 Query 353 AVVGIVTPSDVARLIDVYRLAQPEP 377 +VG+V +++ARL+ R A+ P Sbjct 344 VLVGLVEKAEIARLLQ--RQAEANP 366 >gi|126654899|ref|ZP_01726433.1| hypothetical protein CY0110_10697 [Cyanothece sp. CCY0110] gi|126623634|gb|EAZ94338.1| hypothetical protein CY0110_10697 [Cyanothece sp. CCY0110] Length=373 Score = 184 bits (466), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 111/377 (30%), Positives = 196/377 (52%), Gaps = 9/377 (2%) Query 1 MRDAIPLGRIAG--FVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVM 58 M + I +G + G F VN W ++L L T+S L ++ WLLG A++ Sbjct 1 MNNNIRVGNLFGIPFYVNPSW--FLVLGLVTFSYGGQL-AYFQELNGIIPWLLGFVAAIL 57 Query 59 LLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLA 118 L AS+LAHEL H+ VA G+ V+S+TL+LFGG+ +L E+ TP AF +A AGP SL Sbjct 58 LFASVLAHELGHSFVAISQGIDVKSITLFLFGGLASLEKESDTPLEAFLVAIAGPVVSLL 117 Query 119 LSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRH 178 L+A L I V PA + ++ LA++NL+LGLFNL+PG PLDGG ++++ +W+ Sbjct 118 LAAI---LFIVAFNVSFPAPIEAIIELLASINLVLGLFNLIPGLPLDGGNILKSLVWKIT 174 Query 179 GDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRIST 238 G+ + I A+R G+V + +A+G + G W IG+F+ A Sbjct 175 GNPNKGIIFASRVGQVFGWLAVAVGGLSILGIIQFGNFWTLLIGFFLLQNAGVSAQSAQV 234 Query 239 QQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERH-SAYPVADRDGSITGLVALRQ 297 Q+ G DA+ G + + +F+ YV+G+ + + + +G+++G++ + Sbjct 235 QETLNGYTAEDAVIPDSPIVSGELTIREFVNNYVIGKNQWRKFLIVNEEGNLSGVLEVES 294 Query 298 LRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGI 357 L+ V S + ++ P+ + T + E L +++ + + ++ V+G+ Sbjct 295 LKKVPTSEWIDIKLFEVMEPIKDLITIKSDETLLEVVKMLEDDPQKQLTVIGNNGQVLGL 354 Query 358 VTPSDVARLIDVYRLAQ 374 + + + +L++ + Q Sbjct 355 LEKNSIIKLLEKDKQTQ 371 >gi|67920031|ref|ZP_00513551.1| Peptidase M50 [Crocosphaera watsonii WH 8501] gi|67857515|gb|EAM52754.1| Peptidase M50 [Crocosphaera watsonii WH 8501] Length=421 Score = 183 bits (465), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 107/351 (31%), Positives = 186/351 (53%), Gaps = 13/351 (3%) Query 49 WLLGAGGAVMLLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRI 108 W+ G A+ L S+L HEL H++VA G++V S+TL+LFGGV A+ E+ P AF + Sbjct 49 WIAGLILALFLFISVLLHELGHSLVALTQGINVNSITLFLFGGVAAMEKESDNPTEAFWV 108 Query 109 AFAGPATSLALSATFGALAITLAGVRTPAIVISVAWWL----ATVNLLLGLFNLLPGAPL 164 A AGP SL LS ++ +L + + ++ A +NL+LG+FNL+PG PL Sbjct 109 ASAGPLVSLGLSILLFTVSYSLRSSNNSDTIGRLLVYMTEDTARINLVLGIFNLIPGLPL 168 Query 165 DGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWF 224 DGG++++A +W+ GD AA +G+++ + I+ GL + G + G+W+ FIGWF Sbjct 169 DGGQVLKAIVWKIKGDRFTGVRWAAASGQLIGWLGISFGLLIILLTGSLSGLWIVFIGWF 228 Query 225 IFAAAREEETRISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAY-PVA 283 + A + Q+ + ++ M + +N+ F Q Y+L E H A Sbjct 229 VRRNAENYKNITELQESLLSITASEIMEREFRVVNTHLNLLQFAQNYLLSELHDHMVYFA 288 Query 284 DRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPR 343 +G GL+ + L+++ S+ T ++ D+ PL+++P+ + PL ++E++ + R Sbjct 289 ASEGRYRGLIVVEDLQNIERSQWDTVTLWDVVRPLNTIPSVGEKTPLVTVIEKLEAIHER 348 Query 344 SRALVTEGSAVVGIVTPSDVARLIDV-YRLAQPEPTFTTSPQDADRFSDAG 393 S ++++ AV GI+ D+ + I ++L PE + R D G Sbjct 349 SLSVLSPAGAVAGIIDRGDIVKAIATHHQLPIPET-------EIKRIKDEG 392 >gi|20088906|ref|NP_614981.1| hypothetical protein MA0007 [Methanosarcina acetivorans C2A] gi|19913749|gb|AAM03461.1| conserved hypothetical protein [Methanosarcina acetivorans C2A] Length=364 Score = 182 bits (461), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 120/373 (33%), Positives = 198/373 (54%), Gaps = 24/373 (6%) Query 1 MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATM-LP-GTVGGYPAVVYWLLGAGGAVM 58 M+ A+ +G + G + +H + L+IL +F + A P G G P + + L A++ Sbjct 1 MKSALKIGSVMGIPIRLHITFLLILPIFAYVFAINPYPYGFQGVEPPAIKYALSTLTAIL 60 Query 59 LLASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLA 118 L AS+L HELAH+ +A R GV++ES+TL+LFGGV+++ + P ++A AGP TSL Sbjct 61 LFASILVHELAHSYLAMRYGVNIESITLFLFGGVSSMEEMPRDPGQEAKMASAGPLTSLL 120 Query 119 LSAT----FGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYL 174 + +G + + + + +++ W L +N++LG+FNLLP P+DGGR++RA+ Sbjct 121 IGGVCLLIYGYIIAPNSALSANPVFLTI-WILGAMNIILGIFNLLPAFPMDGGRVLRAFY 179 Query 175 WRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEET 234 RR ++A AA G+ A++L G+ LVG +W I FI+ A EEE Sbjct 180 ARRM-SYIKATQSAAAVGKFFAILLAIFGI-------LVGNLWFPLIALFIYVGASEEER 231 Query 235 RISTQQLFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVA 294 V V D MT T P +N+++ +Q ++ ++H YPV D GS+ G+V Sbjct 232 STQASVTLENVLVKDIMTKNVVTVPSSMNIDELVQ-FMFEKKHMGYPVVD-GGSLKGIVT 289 Query 295 LRQLRDVAPSRRSTTSVGDIAL-PLHSVPT-ARPQEPLTALLERMAPLGPRSRALVTEGS 352 ++ V+ R T V DI + SV + A+ + L + R R LV + Sbjct 290 FTDIQRVSTLDRPVTRVSDIMTRDIISVTSGAQASDALKLVTARNI-----GRVLVIDNG 344 Query 353 AVVGIVTPSDVAR 365 +VG+++ +D+ R Sbjct 345 ELVGVLSRTDLVR 357 Lambda K H 0.324 0.138 0.422 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 767373824232 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40