BLASTP 2.2.25+


Reference:
Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database
search programs", Nucleic Acids Res. 25:3389-3402.



Reference for composition-based statistics:
Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei
Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and
Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST
protein database searches with composition-based statistics and
other refinements", Nucleic Acids Res. 29:2994-3005.



Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
           15,229,318 sequences; 5,219,829,388 total letters



Query= Rv2683

Length=165
                                                                      Score     E
Sequences producing significant alignments:                          (Bits)  Value

gi|15609820|ref|NP_217199.1|  hypothetical protein Rv2683 [Mycoba...   326    9e-88
gi|31793855|ref|NP_856348.1|  hypothetical protein Mb2702 [Mycoba...   324    3e-87
gi|340627684|ref|YP_004746136.1|  hypothetical protein MCAN_27091...   323    6e-87
gi|308369827|ref|ZP_07419202.2|  hypothetical protein TMBG_02820 ...   288    2e-76
gi|254821713|ref|ZP_05226714.1|  hypothetical protein MintA_17397...   258    1e-67
gi|118618649|ref|YP_906981.1|  hypothetical protein MUL_3320 [Myc...   244    3e-63
gi|342858446|ref|ZP_08715101.1|  CBS domain-containing protein [M...   243    5e-63
gi|240169719|ref|ZP_04748378.1|  hypothetical protein MkanA1_1042...   243    6e-63
gi|41408902|ref|NP_961738.1|  hypothetical protein MAP2804 [Mycob...   238    2e-61
gi|183982045|ref|YP_001850336.1|  hypothetical protein MMAR_2031 ...   237    4e-61
gi|118464939|ref|YP_882755.1|  CBS domain-containing protein [Myc...   236    6e-61
gi|336458817|gb|EGO37774.1|  CBS domain-containing protein [Mycob...   236    8e-61
gi|15827502|ref|NP_301765.1|  hypothetical protein ML1037 [Mycoba...   234    2e-60
gi|333991069|ref|YP_004523683.1|  hypothetical protein JDM601_242...   218    3e-55
gi|300785626|ref|YP_003765917.1|  hypothetical protein AMED_3736 ...   196    1e-48
gi|300787610|ref|YP_003767901.1|  hypothetical protein AMED_5750 ...   184    3e-45
gi|294994224|ref|ZP_06799915.1|  hypothetical protein Mtub2_06848...   173    7e-42
gi|300788418|ref|YP_003768709.1|  hypothetical protein AMED_6580 ...   168    3e-40
gi|340530020|gb|AEK45225.1|  hypothetical protein RAM_33760 [Amyc...   166    1e-39
gi|284028455|ref|YP_003378386.1|  putative signal transduction pr...   163    7e-39
gi|302527271|ref|ZP_07279613.1|  CBS domain-containing protein [S...   159    1e-37
gi|345008134|ref|YP_004810488.1|  sodium/hydrogen exchanger [Stre...   132    1e-29
gi|291298032|ref|YP_003509310.1|  CBS domain-containing protein [...   131    3e-29
gi|296268014|ref|YP_003650646.1|  CBS domain-containing protein [...   126    9e-28
gi|269125949|ref|YP_003299319.1|  CBS domain containing protein [...   102    2e-20
gi|336120134|ref|YP_004574912.1|  hypothetical protein MLP_44950 ...  99.4    2e-19
gi|302543782|ref|ZP_07296124.1|  CBS domain protein [Streptomyces...  98.2    3e-19
gi|269128359|ref|YP_003301729.1|  CBS domain containing protein [...  88.2    3e-16
gi|118467949|ref|YP_885255.1|  CBS domain-containing protein [Myc...  86.3    1e-15
gi|108797568|ref|YP_637765.1|  signal transduction protein [Mycob...  83.2    1e-14
gi|119866654|ref|YP_936606.1|  signal transduction protein [Mycob...  83.2    1e-14
gi|297195954|ref|ZP_06913352.1|  CBS domain-containing protein [S...  75.5    3e-12
gi|188584946|ref|YP_001916491.1|  CBS domain containing membrane ...  49.7    2e-04
gi|328952455|ref|YP_004369789.1|  hypothetical protein [Desulfoba...  48.1    5e-04
gi|115523746|ref|YP_780657.1|  signal-transduction protein [Rhodo...  47.4    7e-04
gi|313672485|ref|YP_004050596.1|  cbs domain containing protein [...  46.6    0.001
gi|90425526|ref|YP_533896.1|  signal-transduction protein [Rhodop...  46.6    0.001
gi|91200743|emb|CAJ73795.1|  hypothetical protein kuste3040 [Cand...  45.8    0.002
gi|108803862|ref|YP_643799.1|  CBS domain-containing protein [Rub...  45.4    0.003
gi|289523028|ref|ZP_06439882.1|  putative CBS domain pair [Anaero...  44.7    0.005
gi|330507501|ref|YP_004383929.1|  CBS domain-containing protein [...  44.3    0.005
gi|78357089|ref|YP_388538.1|  hypothetical protein Dde_2046 [Desu...  44.3    0.006
gi|13542143|ref|NP_111831.1|  CBS domain-containing protein [Ther...  43.1    0.014
gi|296132180|ref|YP_003639427.1|  CBS domain containing membrane ...  43.1    0.014
gi|85710518|ref|ZP_01041582.1|  glycerol-3-phosphate dehydrogenas...  42.7    0.017
gi|338740852|ref|YP_004677814.1|  hypothetical protein HYPMC_4039...  42.0    0.030
gi|261403128|ref|YP_003247352.1|  putative signal transduction pr...  42.0    0.033
gi|218779499|ref|YP_002430817.1|  hypothetical protein Dalk_1651 ...  41.6    0.038
gi|86748490|ref|YP_484986.1|  signal-transduction protein [Rhodop...  41.2    0.048
gi|333911316|ref|YP_004485049.1|  putative signal transduction pr...  41.2    0.057


>gi|15609820|ref|NP_217199.1| hypothetical protein Rv2683 [Mycobacterium tuberculosis H37Rv]
 gi|15842221|ref|NP_337258.1| CBS domain-containing protein [Mycobacterium tuberculosis CDC1551]
 gi|148662524|ref|YP_001284047.1| hypothetical protein MRA_2711 [Mycobacterium tuberculosis H37Ra]
 42 more sequence titles
 Length=165

 Score =  326 bits (835),  Expect = 9e-88, Method: Compositional matrix adjust.
 Identities = 165/165 (100%), Positives = 165/165 (100%), Gaps = 0/165 (0%)

Query  1    MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60
            MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK
Sbjct  1    MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60

Query  61   QYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120
            QYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA
Sbjct  61   QYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120

Query  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT  165
            NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT
Sbjct  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT  165


>gi|31793855|ref|NP_856348.1| hypothetical protein Mb2702 [Mycobacterium bovis AF2122/97]
 gi|121638558|ref|YP_978782.1| hypothetical protein BCG_2696 [Mycobacterium bovis BCG str. Pasteur 
1173P2]
 gi|224991050|ref|YP_002645739.1| hypothetical protein JTY_2690 [Mycobacterium bovis BCG str. Tokyo 
172]
 18 more sequence titles
 Length=165

 Score =  324 bits (830),  Expect = 3e-87, Method: Compositional matrix adjust.
 Identities = 164/165 (99%), Positives = 164/165 (99%), Gaps = 0/165 (0%)

Query  1    MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60
            MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK
Sbjct  1    MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60

Query  61   QYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120
            QYAVLPASQVVRFIVPRYVQDDP LAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA
Sbjct  61   QYAVLPASQVVRFIVPRYVQDDPSLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120

Query  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT  165
            NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT
Sbjct  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT  165


>gi|340627684|ref|YP_004746136.1| hypothetical protein MCAN_27091 [Mycobacterium canettii CIPT 
140010059]
 gi|340005874|emb|CCC45040.1| conserved hypothetical protein [Mycobacterium canettii CIPT 140010059]
Length=165

 Score =  323 bits (828),  Expect = 6e-87, Method: Compositional matrix adjust.
 Identities = 163/165 (99%), Positives = 164/165 (99%), Gaps = 0/165 (0%)

Query  1    MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60
            MKVN+DPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK
Sbjct  1    MKVNVDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60

Query  61   QYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120
            QYAVLPASQVVRFIVPRYVQDDP LAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA
Sbjct  61   QYAVLPASQVVRFIVPRYVQDDPSLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120

Query  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT  165
            NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT
Sbjct  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALKT  165


>gi|308369827|ref|ZP_07419202.2| hypothetical protein TMBG_02820 [Mycobacterium tuberculosis SUMu002]
 gi|308371098|ref|ZP_07423811.2| hypothetical protein TMCG_01930 [Mycobacterium tuberculosis SUMu003]
 gi|308372368|ref|ZP_07428408.2| hypothetical protein TMDG_00397 [Mycobacterium tuberculosis SUMu004]
 11 more sequence titles
 Length=147

 Score =  288 bits (736),  Expect = 2e-76, Method: Compositional matrix adjust.
 Identities = 147/147 (100%), Positives = 147/147 (100%), Gaps = 0/147 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY
Sbjct  1    MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS
Sbjct  61   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALKT  165
            PLLAVVKDGSLLGVVTASRLLAAALKT
Sbjct  121  PLLAVVKDGSLLGVVTASRLLAAALKT  147


>gi|254821713|ref|ZP_05226714.1| hypothetical protein MintA_17397 [Mycobacterium intracellulare 
ATCC 13950]
Length=147

 Score =  258 bits (660),  Expect = 1e-67, Method: Compositional matrix adjust.
 Identities = 129/147 (88%), Positives = 143/147 (98%), Gaps = 0/147 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRAEQ+AED+PVVSID+DAL+AARMLAEHRLPGLLVT G+G+ YAVLPASQVVRFIVPRY
Sbjct  1    MRAEQIAEDFPVVSIDADALEAARMLAEHRLPGLLVTDGSGRPYAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNESTADRCAE+LSGKKVRDVLPDHLV+VPPA+ADDTIIEVAA+MARLRS
Sbjct  61   VQDDPSLAGVLNESTADRCAEKLSGKKVRDVLPDHLVDVPPAHADDTIIEVAALMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALKT  165
            PL+AVVKDG L+GV+TASR+LAAALKT
Sbjct  121  PLVAVVKDGGLVGVITASRVLAAALKT  147


>gi|118618649|ref|YP_906981.1| hypothetical protein MUL_3320 [Mycobacterium ulcerans Agy99]
 gi|118570759|gb|ABL05510.1| conserved protein [Mycobacterium ulcerans Agy99]
Length=164

 Score =  244 bits (624),  Expect = 3e-63, Method: Compositional matrix adjust.
 Identities = 125/157 (80%), Positives = 135/157 (86%), Gaps = 0/157 (0%)

Query  8    TAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPA  67
            T  T ATY   MRAE +AE+YPV+SIDSDAL+AAR LAEHRLPGLLVT   G  YAVLPA
Sbjct  7    TLTTPATYGHHMRAEDIAEEYPVISIDSDALEAARTLAEHRLPGLLVTKKTGSPYAVLPA  66

Query  68   SQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTII  127
            SQVVRFIVPRYVQDDP LAGVLNES ADRCAE+L GKKV DVLPDHL +VPP NADDTII
Sbjct  67   SQVVRFIVPRYVQDDPSLAGVLNESMADRCAEKLRGKKVSDVLPDHLNDVPPVNADDTII  126

Query  128  EVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALK  164
            EVAA+MARLRSPLLAVVK+G L GV+TASRLL AAL+
Sbjct  127  EVAALMARLRSPLLAVVKNGKLHGVITASRLLGAALR  163


>gi|342858446|ref|ZP_08715101.1| CBS domain-containing protein [Mycobacterium colombiense CECT 
3035]
 gi|342134150|gb|EGT87330.1| CBS domain-containing protein [Mycobacterium colombiense CECT 
3035]
Length=147

 Score =  243 bits (621),  Expect = 5e-63, Method: Compositional matrix adjust.
 Identities = 121/145 (84%), Positives = 135/145 (94%), Gaps = 0/145 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRAEQ+AED+PVVSI++DALDAARMLAEHRLPGLLVT  +G+ YAVLPASQVVRFIVPRY
Sbjct  1    MRAEQIAEDFPVVSIEADALDAARMLAEHRLPGLLVTDSSGRPYAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNES ADRCAE+LSGK VRDVLPDHLV++PPANADDTIIEVAA+MARLRS
Sbjct  61   VQDDPSLAGVLNESMADRCAEKLSGKTVRDVLPDHLVDIPPANADDTIIEVAALMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAAL  163
            PL+AV K G L+GV+TASR+L AAL
Sbjct  121  PLVAVAKQGRLIGVITASRVLEAAL  145


>gi|240169719|ref|ZP_04748378.1| hypothetical protein MkanA1_10427 [Mycobacterium kansasii ATCC 
12478]
Length=147

 Score =  243 bits (620),  Expect = 6e-63, Method: Compositional matrix adjust.
 Identities = 124/146 (85%), Positives = 133/146 (92%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRAE +AED+PVV ++S ALDAARMLAEHRLPGLLVT  +GK YAVLPASQVVRFIVPRY
Sbjct  1    MRAEDIAEDFPVVDVNSSALDAARMLAEHRLPGLLVTKPSGKPYAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNES ADRCAE+LSGK VRDVLPDHLV+VPP NADDTIIEVAA+MARLRS
Sbjct  61   VQDDPSLAGVLNESMADRCAEKLSGKTVRDVLPDHLVDVPPVNADDTIIEVAAIMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PLL VVKD  LLGV+TASRLLAAALK
Sbjct  121  PLLPVVKDRRLLGVITASRLLAAALK  146


>gi|41408902|ref|NP_961738.1| hypothetical protein MAP2804 [Mycobacterium avium subsp. paratuberculosis 
K-10]
 gi|41397261|gb|AAS05121.1| hypothetical protein MAP_2804 [Mycobacterium avium subsp. paratuberculosis 
K-10]
Length=160

 Score =  238 bits (607),  Expect = 2e-61, Method: Compositional matrix adjust.
 Identities = 117/146 (81%), Positives = 135/146 (93%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA ++AED+PVVS+DSDALDA R+LAEHRLPG++VT  +GK +AVLPASQVVRFIVPRY
Sbjct  14   MRAAELAEDFPVVSVDSDALDATRLLAEHRLPGIVVTDASGKPFAVLPASQVVRFIVPRY  73

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNES ADRCAE+L GK VRDVLPDHLV+VPPA+ADDTIIEVAA+MARLRS
Sbjct  74   VQDDPSLAGVLNESVADRCAEKLRGKTVRDVLPDHLVDVPPADADDTIIEVAALMARLRS  133

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PL+AVVKDG L+GV+TASR+L AAL+
Sbjct  134  PLVAVVKDGRLIGVITASRVLGAALR  159


>gi|183982045|ref|YP_001850336.1| hypothetical protein MMAR_2031 [Mycobacterium marinum M]
 gi|183175371|gb|ACC40481.1| conserved protein [Mycobacterium marinum M]
Length=147

 Score =  237 bits (605),  Expect = 4e-61, Method: Compositional matrix adjust.
 Identities = 120/146 (83%), Positives = 130/146 (90%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRAE +AE+YPV+SIDSDAL+AAR LAEHRLPGLLVT   G  YAVLPASQVVRFIVPRY
Sbjct  1    MRAEDIAEEYPVISIDSDALEAARTLAEHRLPGLLVTKKTGSPYAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNES ADRCAE+L GKKV DVLPDHL +VPP NADDTIIEVAA+MARLRS
Sbjct  61   VQDDPSLAGVLNESMADRCAEKLRGKKVSDVLPDHLNDVPPVNADDTIIEVAALMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PLLAVVK+G L GV+TASRLL AAL+
Sbjct  121  PLLAVVKNGKLHGVITASRLLGAALR  146


>gi|118464939|ref|YP_882755.1| CBS domain-containing protein [Mycobacterium avium 104]
 gi|254776019|ref|ZP_05217535.1| CBS domain-containing protein [Mycobacterium avium subsp. avium 
ATCC 25291]
 gi|118166226|gb|ABK67123.1| CBS domain protein [Mycobacterium avium 104]
Length=147

 Score =  236 bits (603),  Expect = 6e-61, Method: Compositional matrix adjust.
 Identities = 116/146 (80%), Positives = 135/146 (93%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA ++AED+PVVS+DSDALDA R+LAEHRLPG++VT  +GK +AVLPASQVVRFIVPRY
Sbjct  1    MRAAELAEDFPVVSVDSDALDATRLLAEHRLPGIVVTDASGKPFAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNES ADRCAE+L GK VRDVLPDHLV+VPPA+ADDTIIEVAA+MARLRS
Sbjct  61   VQDDPSLAGVLNESVADRCAEKLRGKTVRDVLPDHLVDVPPADADDTIIEVAALMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PL+AVVK+G L+GV+TASR+L AAL+
Sbjct  121  PLVAVVKEGRLIGVITASRVLGAALR  146


>gi|336458817|gb|EGO37774.1| CBS domain-containing protein [Mycobacterium avium subsp. paratuberculosis 
S397]
Length=147

 Score =  236 bits (602),  Expect = 8e-61, Method: Compositional matrix adjust.
 Identities = 116/146 (80%), Positives = 134/146 (92%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA ++AED+PVVS+DSDALDA R+LAEHRLPG++VT  +GK +AVLPASQVVRFIVPRY
Sbjct  1    MRAAELAEDFPVVSVDSDALDATRLLAEHRLPGIVVTDASGKPFAVLPASQVVRFIVPRY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVLNES ADRCAE+L GK VRDVLPDHLV+VPP +ADDTIIEVAA+MARLRS
Sbjct  61   VQDDPSLAGVLNESVADRCAEKLRGKTVRDVLPDHLVDVPPVDADDTIIEVAALMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PL+AVVKDG L+GV+TASR+L AAL+
Sbjct  121  PLVAVVKDGRLIGVITASRVLGAALR  146


>gi|15827502|ref|NP_301765.1| hypothetical protein ML1037 [Mycobacterium leprae TN]
 gi|221229979|ref|YP_002503395.1| hypothetical protein MLBr_01037 [Mycobacterium leprae Br4923]
 gi|699165|gb|AAA62930.1| u1764q [Mycobacterium leprae]
 gi|13093052|emb|CAC31418.1| conserved hypothetical protein [Mycobacterium leprae]
 gi|219933086|emb|CAR71132.1| conserved hypothetical protein [Mycobacterium leprae Br4923]
Length=184

 Score =  234 bits (598),  Expect = 2e-60, Method: Compositional matrix adjust.
 Identities = 121/164 (74%), Positives = 136/164 (83%), Gaps = 0/164 (0%)

Query  1    MKVNIDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGK  60
            +++++  T  T  TYR  M AE +AED+P +SI+S ALDAARMLAEH LPGLLVT  + K
Sbjct  20   VRLDVAHTPRTTQTYRHSMLAEDIAEDFPAISINSSALDAARMLAEHGLPGLLVTDMSDK  79

Query  61   QYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPA  120
             YAVLPASQVVRFIVPRY+QDDP LAGVLNESTAD+ AE+LS KKVRDVLPDHLV V P 
Sbjct  80   PYAVLPASQVVRFIVPRYIQDDPSLAGVLNESTADQAAEKLSSKKVRDVLPDHLVNVSPV  139

Query  121  NADDTIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAALK  164
            NADDTIIEVAA M+R RSPLLAVVK G LLGV+TASRLL AALK
Sbjct  140  NADDTIIEVAATMSRQRSPLLAVVKGGQLLGVITASRLLRAALK  183


>gi|333991069|ref|YP_004523683.1| hypothetical protein JDM601_2429 [Mycobacterium sp. JDM601]
 gi|333487037|gb|AEF36429.1| conserved hypothetical protein [Mycobacterium sp. JDM601]
Length=147

 Score =  218 bits (555),  Expect = 3e-55, Method: Compositional matrix adjust.
 Identities = 110/146 (76%), Positives = 129/146 (89%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRAE++AE++PVV+IDSDA+DAAR+LAEHRLPG++V   AG+ +AVLPASQVVRFIVP Y
Sbjct  1    MRAEEIAEEFPVVAIDSDAVDAARLLAEHRLPGIVVVDAAGQPHAVLPASQVVRFIVPGY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LAGVL+ES ADR AE+L GK VRDVLP+HL E+P A A  T+IEVA+ MARLRS
Sbjct  61   VQDDPSLAGVLSESAADRAAEKLRGKAVRDVLPEHLPELPTAGATHTLIEVASTMARLRS  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PL+AVVKDG LLGV+TASRLLAAALK
Sbjct  121  PLIAVVKDGKLLGVITASRLLAAALK  146


>gi|300785626|ref|YP_003765917.1| hypothetical protein AMED_3736 [Amycolatopsis mediterranei U32]
 gi|299795140|gb|ADJ45515.1| conserved hypothetical protein [Amycolatopsis mediterranei U32]
 gi|340527086|gb|AEK42291.1| hypothetical protein RAM_19025 [Amycolatopsis mediterranei S699]
Length=172

 Score =  196 bits (497),  Expect = 1e-48, Method: Compositional matrix adjust.
 Identities = 99/159 (63%), Positives = 127/159 (80%), Gaps = 0/159 (0%)

Query  5    IDPTAPTFATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAV  64
            ++P +P   +Y   M A +MAE+YPVV +DSDALDAAR+LAE RLPGL+VT  AG   +V
Sbjct  11   VNPASPVGTSYAGTMHAVEMAEEYPVVELDSDALDAARLLAERRLPGLVVTDKAGCPQSV  70

Query  65   LPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADD  124
            LPASQVVRF+VP YV+DDP LAGVLNES ADR A++L G+ VR +LP+ + E+P  N+DD
Sbjct  71   LPASQVVRFLVPSYVRDDPSLAGVLNESMADRVADKLGGRTVRSLLPEEVTELPRVNSDD  130

Query  125  TIIEVAAVMARLRSPLLAVVKDGSLLGVVTASRLLAAAL  163
            TI+EVAA+MARLR PL+AV++D +L GV++ASRLL  AL
Sbjct  131  TIVEVAAMMARLRCPLVAVMEDRTLNGVISASRLLQLAL  169


>gi|300787610|ref|YP_003767901.1| hypothetical protein AMED_5750 [Amycolatopsis mediterranei U32]
 gi|299797124|gb|ADJ47499.1| conserved hypothetical protein [Amycolatopsis mediterranei U32]
 gi|340529146|gb|AEK44351.1| hypothetical protein RAM_29380 [Amycolatopsis mediterranei S699]
Length=148

 Score =  184 bits (468),  Expect = 3e-45, Method: Compositional matrix adjust.
 Identities = 94/145 (65%), Positives = 119/145 (83%), Gaps = 0/145 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M A +MAE+YPVV +DSDALDAAR+LAE RLPGL+VT   G   +VLPASQVV+F++P Y
Sbjct  1    MHAAEMAEEYPVVELDSDALDAARLLAERRLPGLVVTDKTGCPQSVLPASQVVQFLIPNY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            V+DDP LAGVLNES ADR A++L+GK VR +LP+   E+P  ++DDTI+EVAA+MARLR 
Sbjct  61   VRDDPSLAGVLNESMADRVADKLAGKTVRSLLPEKATELPRVSSDDTIVEVAAMMARLRC  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAAL  163
            PL+AV++  +LLGVV+ASRLL  AL
Sbjct  121  PLVAVMEGKTLLGVVSASRLLELAL  145


>gi|294994224|ref|ZP_06799915.1| hypothetical protein Mtub2_06848 [Mycobacterium tuberculosis 
210]
Length=89

 Score =  173 bits (439),  Expect = 7e-42, Method: Compositional matrix adjust.
 Identities = 89/89 (100%), Positives = 89/89 (100%), Gaps = 0/89 (0%)

Query  77   RYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARL  136
            RYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARL
Sbjct  1    RYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARL  60

Query  137  RSPLLAVVKDGSLLGVVTASRLLAAALKT  165
            RSPLLAVVKDGSLLGVVTASRLLAAALKT
Sbjct  61   RSPLLAVVKDGSLLGVVTASRLLAAALKT  89


>gi|300788418|ref|YP_003768709.1| hypothetical protein AMED_6580 [Amycolatopsis mediterranei U32]
 gi|299797932|gb|ADJ48307.1| conserved hypothetical protein [Amycolatopsis mediterranei U32]
Length=148

 Score =  168 bits (425),  Expect = 3e-40, Method: Compositional matrix adjust.
 Identities = 89/146 (61%), Positives = 112/146 (77%), Gaps = 0/146 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M A +MAE+ PVV +DS+ALDA RMLA  RLPG++VT  AG   ++LPAS VVR +VP Y
Sbjct  1    MHAVEMAEECPVVELDSNALDAVRMLAARRLPGIVVTDRAGCPQSILPASHVVRLLVPSY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            V+DDP  AGVL+ES ADR A++L GK VR +LP+   E+P   ADDTI+EVAA+MARLR 
Sbjct  61   VRDDPSPAGVLDESMADRVADKLGGKTVRTLLPEKPSELPRVQADDTIVEVAAIMARLRC  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAALK  164
            PL+AV++D  LLGV++ASRLL  AL 
Sbjct  121  PLVAVMEDKRLLGVISASRLLELALS  146


>gi|340530020|gb|AEK45225.1| hypothetical protein RAM_33760 [Amycolatopsis mediterranei S699]
Length=145

 Score =  166 bits (420),  Expect = 1e-39, Method: Compositional matrix adjust.
 Identities = 87/141 (62%), Positives = 110/141 (79%), Gaps = 0/141 (0%)

Query  23   QMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQDD  82
            +MAE+ PVV +DS+ALDA RMLA  RLPG++VT  AG   ++LPAS VVR +VP YV+DD
Sbjct  2    EMAEECPVVELDSNALDAVRMLAARRLPGIVVTDRAGCPQSILPASHVVRLLVPSYVRDD  61

Query  83   PLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLA  142
            P  AGVL+ES ADR A++L GK VR +LP+   E+P   ADDTI+EVAA+MARLR PL+A
Sbjct  62   PSPAGVLDESMADRVADKLGGKTVRTLLPEKPSELPRVQADDTIVEVAAIMARLRCPLVA  121

Query  143  VVKDGSLLGVVTASRLLAAAL  163
            V++D  LLGV++ASRLL  AL
Sbjct  122  VMEDKRLLGVISASRLLELAL  142


>gi|284028455|ref|YP_003378386.1| putative signal transduction protein with CBS domains [Kribbella 
flavida DSM 17836]
 gi|283807748|gb|ADB29587.1| putative signal transduction protein with CBS domains [Kribbella 
flavida DSM 17836]
Length=148

 Score =  163 bits (413),  Expect = 7e-39, Method: Compositional matrix adjust.
 Identities = 82/141 (59%), Positives = 106/141 (76%), Gaps = 0/141 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M  EQMAE +PVV +DSDA +A  +LA  RLPGL+V    G  ++VLPASQVVRF+VP Y
Sbjct  1    MHGEQMAEQFPVVGLDSDAREAVELLASRRLPGLIVVDEKGSPHSVLPASQVVRFLVPSY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            VQDDP LA V++ES AD+ A++L+G  VR +LP    E+P    DDT++EVAA+MARLR 
Sbjct  61   VQDDPSLARVIDESLADQVADKLAGVTVRKLLPSQPAELPVVKHDDTVLEVAAIMARLRC  120

Query  139  PLLAVVKDGSLLGVVTASRLL  159
            PL+AVVK+  ++G +TASRLL
Sbjct  121  PLVAVVKNKEIIGAITASRLL  141


>gi|302527271|ref|ZP_07279613.1| CBS domain-containing protein [Streptomyces sp. AA4]
 gi|302436166|gb|EFL07982.1| CBS domain-containing protein [Streptomyces sp. AA4]
Length=148

 Score =  159 bits (402),  Expect = 1e-37, Method: Compositional matrix adjust.
 Identities = 93/145 (65%), Positives = 119/145 (83%), Gaps = 0/145 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA  +AE++PVV +D+DAL AAR+LAEHRLPGL+VT  +G  + VLPAS VV+F+VP Y
Sbjct  1    MRAADLAEEFPVVDLDADALAAARLLAEHRLPGLVVTEASGCPHTVLPASDVVQFLVPPY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            V+DDP LAGVL+ES ADR A++L G+ VR++LPD   E+P  +ADDTI+EVAA MARLR 
Sbjct  61   VRDDPSLAGVLSESMADRVADKLGGRTVRELLPDEPRELPRVDADDTIVEVAATMARLRC  120

Query  139  PLLAVVKDGSLLGVVTASRLLAAAL  163
            PL+AV++D +LLGVV+ASRLL  AL
Sbjct  121  PLVAVMRDRTLLGVVSASRLLEHAL  145


>gi|345008134|ref|YP_004810488.1| sodium/hydrogen exchanger [Streptomyces violaceusniger Tu 4113]
 gi|344034483|gb|AEM80208.1| sodium/hydrogen exchanger [Streptomyces violaceusniger Tu 4113]
Length=580

 Score =  132 bits (333),  Expect = 1e-29, Method: Compositional matrix adjust.
 Identities = 78/145 (54%), Positives = 102/145 (71%), Gaps = 4/145 (2%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA  +A  Y  V +D DAL+AAR++AEH+LPGLLV    G+  A+LPASQV++ +VP Y
Sbjct  425  MRARDLAMAYESVRVDDDALEAARLMAEHQLPGLLVLDRDGEPKAILPASQVIKALVPAY  484

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            V +DP LA V++E  ADR  E L G++V D+L D     P A+ DDT +EVAA+MA+ RS
Sbjct  485  VIEDPALAAVIDEKHADRLCEALRGRRVGDLLSDKATRPPIADPDDTALEVAALMAQARS  544

Query  139  PLLAVV---KDG-SLLGVVTASRLL  159
            PL+AV    K G  LLGV+TAS+LL
Sbjct  545  PLVAVARRDKAGLHLLGVITASQLL  569


>gi|291298032|ref|YP_003509310.1| CBS domain-containing protein [Stackebrandtia nassauensis DSM 
44728]
 gi|290567252|gb|ADD40217.1| CBS domain containing protein [Stackebrandtia nassauensis DSM 
44728]
Length=159

 Score =  131 bits (329),  Expect = 3e-29, Method: Compositional matrix adjust.
 Identities = 68/147 (47%), Positives = 100/147 (69%), Gaps = 0/147 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M A  +A+D+P V++D+ AL+AA+++A + LPGL+V    G  Y VL  +QV+R  VP Y
Sbjct  13   MHAGALAKDFPTVTLDTSALEAAKLMAGNDLPGLIVLGSNGCPYTVLGGTQVLRMSVPLY  72

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            +QDDP LAGV++E+ AD     L  K VR++LP+   ++P   A  T++EVAA+MAR+R 
Sbjct  73   IQDDPTLAGVVDEAAADTFVAGLGNKTVRELLPEEPFDLPVVGARATLLEVAALMARVRI  132

Query  139  PLLAVVKDGSLLGVVTASRLLAAALKT  165
            P++AVV + +LLG +T   LL  AL T
Sbjct  133  PVVAVVDNDTLLGAITVDSLLDHALGT  159


>gi|296268014|ref|YP_003650646.1| CBS domain-containing protein [Thermobispora bispora DSM 43833]
 gi|296090801|gb|ADG86753.1| CBS domain containing protein [Thermobispora bispora DSM 43833]
Length=147

 Score =  126 bits (317),  Expect = 9e-28, Method: Compositional matrix adjust.
 Identities = 67/141 (48%), Positives = 95/141 (68%), Gaps = 0/141 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA  +    P VS+DS  +DAA ++ E +LPGL+V    G  Y++L  +QV+R  +P+Y
Sbjct  1    MRARDLMVPSPAVSLDSPVIDAANLMIESKLPGLIVLDERGTPYSILSGTQVLRLAIPQY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
             Q+DP LA V++E+ ADR AE LS + VR VLPD   E+P A+ D T++E+AA+MAR R 
Sbjct  61   CQEDPALARVIDEAHADRFAEALSRRTVRQVLPDRPSELPIADPDATLLELAALMARTRC  120

Query  139  PLLAVVKDGSLLGVVTASRLL  159
            PL+A+V+ G LLG V    L+
Sbjct  121  PLVAIVEKGRLLGAVALHPLM  141


>gi|269125949|ref|YP_003299319.1| CBS domain containing protein [Thermomonospora curvata DSM 43183]
 gi|268310907|gb|ACY97281.1| CBS domain containing protein [Thermomonospora curvata DSM 43183]
Length=153

 Score =  102 bits (253),  Expect = 2e-20, Method: Compositional matrix adjust.
 Identities = 63/150 (42%), Positives = 92/150 (62%), Gaps = 5/150 (3%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M A ++A  YP +  DS+AL  AR++ E RLPGL+V        A+LP SQ++ F +P Y
Sbjct  1    MLARELARPYPHIDPDSEALSVARLVIEQRLPGLIVLDDLQHPLAILPTSQILWFAIPPY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            V++DP LA V +E  ADR  ER+ G+ +RD+LP      P    D  ++EVA +MA+  S
Sbjct  61   VREDPALARVYSERQADRMCERMRGRSLRDLLPPEPRRPPMVTGDANVLEVATLMAQAHS  120

Query  139  PLLAVV--KDG---SLLGVVTASRLLAAAL  163
            PL+AVV  K+G    ++GV++ + LL   L
Sbjct  121  PLVAVVESKNGPRPPMIGVISVADLLGRLL  150


>gi|336120134|ref|YP_004574912.1| hypothetical protein MLP_44950 [Microlunatus phosphovorus NM-1]
 gi|334687924|dbj|BAK37509.1| hypothetical protein MLP_44950 [Microlunatus phosphovorus NM-1]
Length=152

 Score = 99.4 bits (246),  Expect = 2e-19, Method: Compositional matrix adjust.
 Identities = 61/142 (43%), Positives = 85/142 (60%), Gaps = 1/142 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M+A  +A + P V++D     A +++A+ +LPGL+V   A    AVLP SQV+R IV + 
Sbjct  1    MQASDIAVEVPTVTLDDPVTRAVKIMADRQLPGLIVVDRASHPRAVLPGSQVLRMIVAQT  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
             Q DP LA  ++E+ AD   + L  + V D LP    +     AD T++EVA VMAR+ S
Sbjct  61   YQRDPALARTIDEAHADLFWQELEHRTVSDCLPPQPSKKVAVQADATLLEVAGVMARMHS  120

Query  139  PLLAVVK-DGSLLGVVTASRLL  159
            PL+AVV  DG L G +T S LL
Sbjct  121  PLVAVVAPDGRLSGCITLSALL  142


>gi|302543782|ref|ZP_07296124.1| CBS domain protein [Streptomyces hygroscopicus ATCC 53653]
 gi|302461400|gb|EFL24493.1| CBS domain protein [Streptomyces himastatinicus ATCC 53653]
Length=137

 Score = 98.2 bits (243),  Expect = 3e-19, Method: Compositional matrix adjust.
 Identities = 66/120 (55%), Positives = 85/120 (71%), Gaps = 0/120 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M A  +A +Y  VS+D DAL AAR+LAE +LPGLLV  G G+  A+LPASQVV+ +VP Y
Sbjct  1    MCARDLAVEYESVSVDDDALAAARLLAERQLPGLLVLDGDGEPKAILPASQVVKALVPGY  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            V +DP LA V++E+ ADR  E L G++V D+L D     P A  DDT +EVAA+MAR+RS
Sbjct  61   VVEDPALAAVVDENHADRLCEALRGRRVGDLLSDEAARPPIAAPDDTALEVAALMARVRS  120


>gi|269128359|ref|YP_003301729.1| CBS domain containing protein [Thermomonospora curvata DSM 43183]
 gi|268313317|gb|ACY99691.1| CBS domain containing protein [Thermomonospora curvata DSM 43183]
Length=152

 Score = 88.2 bits (217),  Expect = 3e-16, Method: Compositional matrix adjust.
 Identities = 54/144 (38%), Positives = 79/144 (55%), Gaps = 1/144 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            MRA  +A   P V++        R++A  RLPGL+V     +   V+P +Q++R +VPR 
Sbjct  1    MRARDIAIQVPTVAVGDSVTRTVRVMALGRLPGLIVVDERRRPRMVVPGTQILRMLVPRS  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
             Q+DP LA  ++E  AD     L    + D L D          D T++E AA+MAR R+
Sbjct  61   YQEDPALARTVDEPHADLFWRELGELTIGDFLHDQDFRPVTVREDATLLEAAALMARRRT  120

Query  139  PLLAVV-KDGSLLGVVTASRLLAA  161
            PL+ VV +DG++ G VT  RLL +
Sbjct  121  PLVVVVDRDGTMTGAVTLDRLLGS  144


>gi|118467949|ref|YP_885255.1| CBS domain-containing protein [Mycobacterium smegmatis str. MC2 
155]
 gi|118169236|gb|ABK70132.1| CBS domain protein [Mycobacterium smegmatis str. MC2 155]
Length=152

 Score = 86.3 bits (212),  Expect = 1e-15, Method: Compositional matrix adjust.
 Identities = 54/144 (38%), Positives = 79/144 (55%), Gaps = 1/144 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M+A ++A   P V ID     A +++  +RLPGL+V     +  AVLP +QV++  +P  
Sbjct  1    MQAHEIAVHPPTVRIDDPVSKAVQLMVVNRLPGLVVVDDLDRPVAVLPGTQVLKLAIPES  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
             +DDP L   ++E  AD          V D LP+ +        D T++E+A +MA  RS
Sbjct  61   YRDDPALVRTVDEIHADLFWHGPGKLTVGDCLPNPVATPATVAPDATLLEIATIMANKRS  120

Query  139  PLLAVV-KDGSLLGVVTASRLLAA  161
            PL+AVV +DG L G VT  RLL +
Sbjct  121  PLIAVVDRDGKLTGAVTLERLLTS  144


>gi|108797568|ref|YP_637765.1| signal transduction protein [Mycobacterium sp. MCS]
 gi|108767987|gb|ABG06709.1| putative signal transduction protein with CBS domains [Mycobacterium 
sp. MCS]
Length=234

 Score = 83.2 bits (204),  Expect = 1e-14, Method: Compositional matrix adjust.
 Identities = 55/144 (39%), Positives = 77/144 (54%), Gaps = 1/144 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M+A ++A   P V +D     A +++  +RLPGL+V   A    AVLP +QV+R  +P  
Sbjct  83   MQAHEIAVSPPTVRMDDPVSKAVQLMVVNRLPGLVVVDDADHPIAVLPGTQVLRLTIPET  142

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
             +DDP L   ++E  AD          V D LP  + +      D T++EVA VMA  RS
Sbjct  143  YRDDPALVRTVDEIHADLFWHGPGRLTVGDCLPSPVAKPATVAPDATLLEVATVMATKRS  202

Query  139  PLLAVVKD-GSLLGVVTASRLLAA  161
            PL+A+V   G L G VT  RLL +
Sbjct  203  PLIAIVDGAGRLTGAVTLERLLTS  226


>gi|119866654|ref|YP_936606.1| signal transduction protein [Mycobacterium sp. KMS]
 gi|126433190|ref|YP_001068881.1| signal transduction protein [Mycobacterium sp. JLS]
 gi|119692743|gb|ABL89816.1| putative signal transduction protein with CBS domains [Mycobacterium 
sp. KMS]
 gi|126232990|gb|ABN96390.1| putative signal transduction protein with CBS domains [Mycobacterium 
sp. JLS]
Length=152

 Score = 83.2 bits (204),  Expect = 1e-14, Method: Compositional matrix adjust.
 Identities = 55/144 (39%), Positives = 77/144 (54%), Gaps = 1/144 (0%)

Query  19   MRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRY  78
            M+A ++A   P V +D     A +++  +RLPGL+V   A    AVLP +QV+R  +P  
Sbjct  1    MQAHEIAVSPPTVRMDDPVSKAVQLMVVNRLPGLVVVDDADHPIAVLPGTQVLRLTIPET  60

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
             +DDP L   ++E  AD          V D LP  + +      D T++EVA VMA  RS
Sbjct  61   YRDDPALVRTVDEIHADLFWHGPGRLTVGDCLPSPVAKPATVAPDATLLEVATVMATKRS  120

Query  139  PLLAVVKD-GSLLGVVTASRLLAA  161
            PL+A+V   G L G VT  RLL +
Sbjct  121  PLIAIVDGAGRLTGAVTLERLLTS  144


>gi|297195954|ref|ZP_06913352.1| CBS domain-containing protein [Streptomyces pristinaespiralis 
ATCC 25486]
 gi|297153006|gb|EDY62756.2| CBS domain-containing protein [Streptomyces pristinaespiralis 
ATCC 25486]
Length=108

 Score = 75.5 bits (184),  Expect = 3e-12, Method: Compositional matrix adjust.
 Identities = 36/68 (53%), Positives = 49/68 (73%), Gaps = 0/68 (0%)

Query  24  MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQDDP  83
           +AE YP V+ D  A+DAAR+LAE  LP LLV    G  YA++P SQ+VR ++P Y+ +DP
Sbjct  32  LAETYPFVTTDDSAMDAARLLAERALPALLVLDADGHPYAIVPGSQLVRQLLPHYIVEDP  91

Query  84  LLAGVLNE  91
           LLA V++E
Sbjct  92  LLAAVVDE  99


>gi|188584946|ref|YP_001916491.1| CBS domain containing membrane protein [Natranaerobius thermophilus 
JW/NM-WN-LF]
 gi|179349633|gb|ACB83903.1| CBS domain containing membrane protein [Natranaerobius thermophilus 
JW/NM-WN-LF]
Length=147

 Score = 49.7 bits (117),  Expect = 2e-04, Method: Compositional matrix adjust.
 Identities = 43/153 (29%), Positives = 74/153 (49%), Gaps = 14/153 (9%)

Query  19   MRAEQ-MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVV----RF  73
            MRA+  M+ D   VS +S   +AA+++A+  + G+ V         ++    ++    R 
Sbjct  1    MRAKDIMSTDIVTVSPESTVEEAAKLMADREISGIPVINSQNDLVGIITEGDLLGKHKRI  60

Query  74   IVPRYVQDDPLLAGVLNESTADRCAERLS---GKKVRDVLPDHLVEVPPANADDTIIEVA  130
              P Y++    L G++   + D   E+L      +V+D++ D +V V P      I E+A
Sbjct  61   SPPGYIE---FLGGIVFTESQDEFFEQLRKYVATQVKDLMSDQVVTVGPEAG---IEEIA  114

Query  131  AVMARLRSPLLAVVKDGSLLGVVTASRLLAAAL  163
              M +     L VV +G LLG+V+ + LL A L
Sbjct  115  TTMDQKNVKRLPVVGEGKLLGIVSRADLLKALL  147


>gi|328952455|ref|YP_004369789.1| hypothetical protein [Desulfobacca acetoxidans DSM 11109]
 gi|328452779|gb|AEB08608.1| CBS domain containing membrane protein [Desulfobacca acetoxidans 
DSM 11109]
Length=151

 Score = 48.1 bits (113),  Expect = 5e-04, Method: Compositional matrix adjust.
 Identities = 37/134 (28%), Positives = 67/134 (50%), Gaps = 7/134 (5%)

Query  24   MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVV----RFIVPRYV  79
            M +    V+  +  LD AR+LA+H++ G  V    G+   V+  + ++    +F +P  V
Sbjct  8    MTKTVITVTPQTSVLDLARLLAQHKINGTPVVDDDGRLVGVITQTDLIDRAKKFQLPHVV  67

Query  80   QDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSP  139
                    +   ST  +  E++ G +V DV+    + + P  + D   EVA +MA   + 
Sbjct  68   TILDAHFYLERPSTFRKNLEKMLGNQVADVMTAPAITITPELSVD---EVATIMAHRNAH  124

Query  140  LLAVVKDGSLLGVV  153
             L V++DG+L+GV+
Sbjct  125  TLPVLQDGNLVGVI  138


>gi|115523746|ref|YP_780657.1| signal-transduction protein [Rhodopseudomonas palustris BisA53]
 gi|115517693|gb|ABJ05677.1| putative signal-transduction protein with CBS domains [Rhodopseudomonas 
palustris BisA53]
Length=242

 Score = 47.4 bits (111),  Expect = 7e-04, Method: Compositional matrix adjust.
 Identities = 44/151 (30%), Positives = 71/151 (48%), Gaps = 17/151 (11%)

Query  19   MRAEQ-MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIV--  75
            MRA Q M  D   V  ++  +DAA ++ +  + GL V   AG+   V+     +R     
Sbjct  1    MRAHQIMTHDVVTVGPEASIVDAANIMLKQHVSGLPVVNDAGELIGVISEGDFIRRTEIG  60

Query  76   -----PRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVA  130
                  R+++   LL G   +S +D   E   G+KV +++  H   V    AD T+ E+ 
Sbjct  61   TERKRGRWLR---LLLGP-GQSASDFVHEH--GRKVSEIMTSHPHTV---QADATVSEIV  111

Query  131  AVMARLRSPLLAVVKDGSLLGVVTASRLLAA  161
              M +     L V++DG ++G+VT   LL A
Sbjct  112  KTMEKYHVKRLPVLQDGRMVGIVTRKNLLKA  142


>gi|313672485|ref|YP_004050596.1| cbs domain containing protein [Calditerrivibrio nitroreducens 
DSM 19672]
 gi|312939241|gb|ADR18433.1| CBS domain containing protein [Calditerrivibrio nitroreducens 
DSM 19672]
Length=165

 Score = 46.6 bits (109),  Expect = 0.001, Method: Compositional matrix adjust.
 Identities = 30/105 (29%), Positives = 55/105 (53%), Gaps = 6/105 (5%)

Query  49   LPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRD  108
            + G+LV  G  K    L    V+R ++P Y+  +PLL+    E      A R+  KKV++
Sbjct  40   VKGMLVMNGD-KVVGTLSMEDVLRSVIPFYI--NPLLSDFTWEGMLLNMASRMCNKKVKE  96

Query  109  VLPDHLVEVPPANADDTIIEVAAVMARLRSPLLAVVKDGSLLGVV  153
            ++  +L+    A  DD+++E A  + +     L VV+ G ++G++
Sbjct  97   IMNKNLI---FAEQDDSLMECAEKLIKYNLQRLPVVEKGKVVGII  138


>gi|90425526|ref|YP_533896.1| signal-transduction protein [Rhodopseudomonas palustris BisB18]
 gi|90107540|gb|ABD89577.1| putative signal-transduction protein with CBS domains [Rhodopseudomonas 
palustris BisB18]
Length=242

 Score = 46.6 bits (109),  Expect = 0.001, Method: Compositional matrix adjust.
 Identities = 44/151 (30%), Positives = 71/151 (48%), Gaps = 17/151 (11%)

Query  19   MRAEQ-MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIV--  75
            MRA Q M      VS D+  +DAA ++    + GL V   AG+   ++     +R     
Sbjct  1    MRAHQIMTRQVVTVSPDASIVDAANIMLSQHVSGLPVVNAAGELIGIISEGDFIRRAEIG  60

Query  76   -----PRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVA  130
                  R+++   LL G   +S +D   E   G+KV +++  H   V   NA+ T+ E+ 
Sbjct  61   TERKRGRWLR---LLLG-PGQSASDFVHEH--GRKVGEIMTTHPHTV---NAEATVAEIV  111

Query  131  AVMARLRSPLLAVVKDGSLLGVVTASRLLAA  161
              M +     L V++DG ++G+VT   LL A
Sbjct  112  KAMEKHHVKRLPVMQDGRMVGIVTRKNLLQA  142


>gi|91200743|emb|CAJ73795.1| hypothetical protein kuste3040 [Candidatus Kuenenia stuttgartiensis]
Length=151

 Score = 45.8 bits (107),  Expect = 0.002, Method: Compositional matrix adjust.
 Identities = 37/141 (27%), Positives = 66/141 (47%), Gaps = 11/141 (7%)

Query  24   MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQDDP  83
            M  D  VV       +   ML + R   + V     K   V+  + +++ ++P+Y+  D 
Sbjct  7    MVTDPTVVPASGTFYNLMEMLGKIRFHVIFVVDDKEKLVGVVTETDLLKVLMPKYLNSDD  66

Query  84   LLAGVLNESTAD-RCAERLSGKKVRDVLPDHLVEVP----PANADDTIIEVAAVMARLRS  138
             L  ++ E   D RC E       +D+    ++  P     A+ +DTII+VAA M   + 
Sbjct  67   ALFSIMGEDYFDKRCLE------CKDMDITEIMSKPILAATASENDTIIKVAAAMLNRKI  120

Query  139  PLLAVVKDGSLLGVVTASRLL  159
              + V++DG ++G+V+   LL
Sbjct  121  HAVPVLRDGKVVGIVSRLVLL  141


>gi|108803862|ref|YP_643799.1| CBS domain-containing protein [Rubrobacter xylanophilus DSM 9941]
 gi|108765105|gb|ABG03987.1| CBS domain containing membrane protein [Rubrobacter xylanophilus 
DSM 9941]
Length=159

 Score = 45.4 bits (106),  Expect = 0.003, Method: Compositional matrix adjust.
 Identities = 43/152 (29%), Positives = 72/152 (48%), Gaps = 8/152 (5%)

Query  13   ATYRRDMRAEQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVR  72
             + R D+    +      VS D+ A +A R+L EHR+PGL V  G G+    +    ++ 
Sbjct  6    GSGREDLSLRDLVRPSASVSPDAPAREALRLLLEHRVPGLPVVDGEGRPVGFVSDGNLLA  65

Query  73   FIVPRYVQDDPLLAGVLNESTADRCAERL---SGKKVRDVLPDHLVEVPPANADDTIIEV  129
              +PRY+     L+ V    T D     L   + + VR+V+ + +  V   +AD + +E 
Sbjct  66   SALPRYLTMMEDLSFV--RETGDEWVHYLAEAADRPVREVMSEKVATV---DADTSELEA  120

Query  130  AAVMARLRSPLLAVVKDGSLLGVVTASRLLAA  161
            A  M       + V ++G ++GVV+   L AA
Sbjct  121  AREMVVEGVSSVVVTENGRMIGVVSRLDLYAA  152


>gi|289523028|ref|ZP_06439882.1| putative CBS domain pair [Anaerobaculum hydrogeniformans ATCC 
BAA-1850]
 gi|289503571|gb|EFD24735.1| putative CBS domain pair [Anaerobaculum hydrogeniformans ATCC 
BAA-1850]
Length=155

 Score = 44.7 bits (104),  Expect = 0.005, Method: Compositional matrix adjust.
 Identities = 33/138 (24%), Positives = 66/138 (48%), Gaps = 7/138 (5%)

Query  22   EQMAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQ-  80
            E M +D  V+S D   +DA +M   H++ G+ V  G       +  S +++  +P Y++ 
Sbjct  7    EVMQKDLTVLSKDDLVIDAVKMFYIHKVTGVPVIEGNWYLVGFISESDILKAALPTYLET  66

Query  81   --DDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
                  L+     S  D+  + +  ++V + +   ++ V P+    +++ +A +M R R 
Sbjct  67   ITSSTFLSNNGELSLFDKIHD-IGLRRVEEFMTREVISVDPSA---SLMSIADMMIRKRI  122

Query  139  PLLAVVKDGSLLGVVTAS  156
              L V KDG  +G++  S
Sbjct  123  KRLPVAKDGKYIGIIDRS  140


>gi|330507501|ref|YP_004383929.1| CBS domain-containing protein [Methanosaeta concilii GP6]
 gi|328928309|gb|AEB68111.1| CBS domain protein [Methanosaeta concilii GP6]
Length=160

 Score = 44.3 bits (103),  Expect = 0.005, Method: Compositional matrix adjust.
 Identities = 39/136 (29%), Positives = 67/136 (50%), Gaps = 18/136 (13%)

Query  39   DAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIV-------------PRYVQDDPLL  85
            +AAR+L E+++ G+ V  G  +   ++  S ++R +              P  + + P  
Sbjct  22   EAARLLKENKISGMPVLDGE-RLVGIVSESDLLRLLSVEDESEGSLWLPSPFEIFEVPFR  80

Query  86   AGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLAVVK  145
              V  E       E +  K+V DV+  +L E+ P   DD+I E A++M R R   L VV+
Sbjct  81   DLVKWERMRSSLKE-IPEKEVADVMSRNLHEIGP---DDSIEEAASIMTRHRINRLPVVE  136

Query  146  DGSLLGVVTASRLLAA  161
            DG L+G+VT   +++ 
Sbjct  137  DGRLVGIVTRGDIISG  152


>gi|78357089|ref|YP_388538.1| hypothetical protein Dde_2046 [Desulfovibrio alaskensis G20]
 gi|78219494|gb|ABB38843.1| CBS domain containing membrane protein [Desulfovibrio alaskensis 
G20]
Length=150

 Score = 44.3 bits (103),  Expect = 0.006, Method: Compositional matrix adjust.
 Identities = 43/143 (31%), Positives = 69/143 (49%), Gaps = 13/143 (9%)

Query  24   MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVV----RFIVPRYV  79
            M+ D   V+ D D ++A +++ E++  GL V   AGK   VL  S +V    +  +P   
Sbjct  8    MSADPVTVAPDMDIIEATKLMLEYKFNGLPVVDDAGKLVGVLCQSDLVAQQKKVNLPSLF  67

Query  80   QDDPLLAGVL---NESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARL  136
                +L G +   + S  D    +++  +V D + D+   V P   D  + EVA +M   
Sbjct  68   T---ILDGFIPLKSLSDMDSEMRKVAATRVSDAMTDNPATVTP---DTPLDEVATLMVDS  121

Query  137  RSPLLAVVKDGSLLGVVTASRLL  159
            +   L VVKDG L+GVV    +L
Sbjct  122  KYYTLPVVKDGILVGVVGKEDVL  144


>gi|13542143|ref|NP_111831.1| CBS domain-containing protein [Thermoplasma volcanium GSS1]
Length=176

 Score = 43.1 bits (100),  Expect = 0.014, Method: Compositional matrix adjust.
 Identities = 28/102 (28%), Positives = 47/102 (47%), Gaps = 22/102 (21%)

Query  19   MRAEQ-MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPR  77
            MR E+ M  +Y  V+ +S   DA +++ E+RL GL+V    GK   ++    +++  +PR
Sbjct  1    MRVEKIMNTNYRSVNENSSVFDAVKIMNENRLYGLIVKDNEGKDVGLISERSIIKRFIPR  60

Query  78   ----------YVQDDPL-----------LAGVLNESTADRCA  98
                      YV   P+            A  L+E+  +RCA
Sbjct  61   NKKPDEVQIKYVMRKPIPKVPSSYDVRDAAAYLSENGLERCA  102


>gi|296132180|ref|YP_003639427.1| CBS domain containing membrane protein [Thermincola sp. JR]
 gi|296030758|gb|ADG81526.1| CBS domain containing membrane protein [Thermincola potens JR]
Length=150

 Score = 43.1 bits (100),  Expect = 0.014, Method: Compositional matrix adjust.
 Identities = 38/133 (29%), Positives = 67/133 (51%), Gaps = 13/133 (9%)

Query  39   DAARMLAEHRLPGLLVTAGAGKQYAVLPAS----QVVRFIVPRYVQDDPLLAGVLNESTA  94
            + A++LA+ ++ G+ V   AGK   ++  +    Q  +  VP YVQ   LL G++   + 
Sbjct  22   EVAKILADKKISGVPVVDEAGKIVGIVTEADLLVQTQKLKVPSYVQ---LLGGIIYLDSV  78

Query  95   DRCAERLSGK---KVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLAVVKDGSLLG  151
                E L      +V+D++   +V V     D  I ++A  MA      L VV+DG+L+G
Sbjct  79   KEFEEDLRKAVAVQVKDIMTTDVVTV---EEDAEIEDIATTMADEGINRLPVVRDGALVG  135

Query  152  VVTASRLLAAALK  164
            +V+ + ++ A  K
Sbjct  136  IVSRADIVKALAK  148


>gi|85710518|ref|ZP_01041582.1| glycerol-3-phosphate dehydrogenase [Erythrobacter sp. NAP1]
 gi|85687696|gb|EAQ27701.1| glycerol-3-phosphate dehydrogenase [Erythrobacter sp. NAP1]
Length=493

 Score = 42.7 bits (99),  Expect = 0.017, Method: Compositional matrix adjust.
 Identities = 36/105 (35%), Positives = 52/105 (50%), Gaps = 3/105 (2%)

Query  9    APTFATYRRDMRAEQMAEDYP-VVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPA  67
            A + +T  RD + E + ED P ++SI    L   R LAEH L  + +  G+    AVLP 
Sbjct  326  AASNSTVTRDYQFE-LEEDGPKLLSIFGGKLTTYRKLAEHALERIGIDGGSWTADAVLPG  384

Query  68   SQVVRFIVPRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPD  112
             ++      R+V D   L   L+E T  R A R  G ++ D+L D
Sbjct  385  GEIDPIYFDRFVGDQAALFPWLDEKTVLRLA-RAYGTRMIDLLGD  428


>gi|338740852|ref|YP_004677814.1| hypothetical protein HYPMC_4039 [Hyphomicrobium sp. MC1]
 gi|337761415|emb|CCB67248.1| conserved protein of unknown function [Hyphomicrobium sp. MC1]
Length=242

 Score = 42.0 bits (97),  Expect = 0.030, Method: Compositional matrix adjust.
 Identities = 42/137 (31%), Positives = 69/137 (51%), Gaps = 14/137 (10%)

Query  30   VVSIDSDAL--DAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFI-----VPRYVQDD  82
            V+SI  DA   +  + + +HR+ GL V +  GK   V+     +R       V R    D
Sbjct  11   VISIRPDATLSEMIKKMLDHRISGLPVVSEDGKLVGVVTEGDCLRRAETGTEVKRSFWRD  70

Query  83   PLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLA  142
             +L G  +E+ A+    R  G+KV +V+    + V P   D  + EV  VM + R   + 
Sbjct  71   -MLTG--SETLANEYI-RTHGRKVSEVMTRDPISVSP---DTELSEVIHVMEKNRIKRVP  123

Query  143  VVKDGSLLGVVTASRLL  159
            VVKDG+++G+++ + LL
Sbjct  124  VVKDGAVVGILSRANLL  140


>gi|261403128|ref|YP_003247352.1| putative signal transduction protein with CBS domains [Methanocaldococcus 
vulcanius M7]
 gi|261370121|gb|ACX72870.1| putative signal transduction protein with CBS domains [Methanocaldococcus 
vulcanius M7]
Length=194

 Score = 42.0 bits (97),  Expect = 0.033, Method: Compositional matrix adjust.
 Identities = 33/137 (25%), Positives = 63/137 (46%), Gaps = 26/137 (18%)

Query  28   YPVVSIDSD--ALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIVPRYVQDDPLL  85
            +PV++   D    D A ++ EH + G +V     K   +L    +V+ +V + ++   +L
Sbjct  15   FPVITAKKDMSVYDIANIMTEHNI-GAVVIVEDNKPVGILTERDIVKRVVSKNLKPKEVL  73

Query  86   AGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLAVVK  145
            A            E +  KK+  +           + + +I E A +MA+     L VVK
Sbjct  74   A------------EEVMSKKIITI-----------HQNASITEAAKIMAKYGVKRLPVVK  110

Query  146  DGSLLGVVTASRLLAAA  162
            DG+L+G++T S ++  +
Sbjct  111  DGNLMGIITQSDIIKIS  127


>gi|218779499|ref|YP_002430817.1| hypothetical protein Dalk_1651 [Desulfatibacillum alkenivorans 
AK-01]
 gi|218760883|gb|ACL03349.1| CBS domain containing membrane protein [Desulfatibacillum alkenivorans 
AK-01]
Length=149

 Score = 41.6 bits (96),  Expect = 0.038, Method: Compositional matrix adjust.
 Identities = 40/133 (31%), Positives = 65/133 (49%), Gaps = 13/133 (9%)

Query  34   DSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVV----RFIVPRYVQDDPLLAGVL  89
            D+D  +AA+ L E+R+ G  V    GK   +L  S ++    RF VP +     LL  V+
Sbjct  18   DTDISEAAKQLLENRINGAPVVDEDGKVVGILCQSDLIVQQKRFPVPSFFT---LLDSVI  74

Query  90   ---NESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRSPLLAVVKD  146
               ++   ++  E+++  KV   + +  V V P   D  + +VAA+M   +   L VV  
Sbjct  75   PLVSQKHFEKEMEKMAAFKVSQAMTEKPVVVSP---DTPLEDVAALMVDKKLHTLPVVDS  131

Query  147  GSLLGVVTASRLL  159
            G L+GVV    +L
Sbjct  132  GKLVGVVGKEDIL  144


>gi|86748490|ref|YP_484986.1| signal-transduction protein [Rhodopseudomonas palustris HaA2]
 gi|86571518|gb|ABD06075.1| putative signal-transduction protein with CBS domains [Rhodopseudomonas 
palustris HaA2]
Length=243

 Score = 41.2 bits (95),  Expect = 0.048, Method: Compositional matrix adjust.
 Identities = 43/152 (29%), Positives = 68/152 (45%), Gaps = 19/152 (12%)

Query  19   MRAEQ-MAEDYPVVSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIV--  75
            MRA Q M  +   +  ++  +DAA  + EH + GL V  G G+   ++     +R     
Sbjct  1    MRANQIMTANLVTIGPEASIVDAANAMLEHHVSGLPVVDGGGRLIGIISEGDFIRRAELG  60

Query  76   -----PRYVQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIE-V  129
                  R+++   LL G      AD   E   G+KV +V+  H    P   ++DT IE +
Sbjct  61   TQRKRSRWLR---LLLGP-GTCAADFVHEH--GRKVGEVMTHH----PHTISEDTSIEAI  110

Query  130  AAVMARLRSPLLAVVKDGSLLGVVTASRLLAA  161
               M +     L V++   L+G+VT   LL A
Sbjct  111  VRTMEKHHVKRLPVMRGDQLVGIVTRKNLLRA  142


>gi|333911316|ref|YP_004485049.1| putative signal transduction protein with CBS domains [Methanotorris 
igneus Kol 5]
 gi|333751905|gb|AEF96984.1| putative signal transduction protein with CBS domains [Methanotorris 
igneus Kol 5]
Length=153

 Score = 41.2 bits (95),  Expect = 0.057, Method: Compositional matrix adjust.
 Identities = 39/143 (28%), Positives = 65/143 (46%), Gaps = 17/143 (11%)

Query  31   VSIDSDALDAARMLAEHRLPGLLVTAGAGKQYAVLPASQVVRFIV------------PRY  78
            V+ D D  D  R+  EH++ G  V    GK   ++  S +V+ I             P  
Sbjct  14   VNPDDDIRDVIRLFREHKISGAPVVED-GKLVGIISESDIVKTITTHNESIGLILPSPLD  72

Query  79   VQDDPLLAGVLNESTADRCAERLSGKKVRDVLPDHLVEVPPANADDTIIEVAAVMARLRS  138
            + + PL   +  E   +   + L  K V+DV+   ++ + P   D+TI + A +M     
Sbjct  73   LIELPLKTTLKIEEFKEDIKKALKTK-VKDVMTKDVITISP---DETINDAAKLMIENNI  128

Query  139  PLLAVVKDGSLLGVVTASRLLAA  161
              L VV++G L+G+VT   L+ A
Sbjct  129  KRLPVVENGKLVGIVTRGDLIEA  151



Lambda     K      H
   0.319    0.134    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 

Effective search space used: 128736477480


  Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF
excluding environmental samples from WGS projects
    Posted date:  Sep 5, 2011  4:36 AM
  Number of letters in database: 5,219,829,388
  Number of sequences in database:  15,229,318



Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Neighboring words threshold: 11
Window for multiple hits: 40