BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2754c Length=250 Score E Sequences producing significant alignments: (Bits) Value gi|308369848|ref|ZP_07419275.2| thymidylate synthase thyX [Mycob... 512 2e-143 gi|15609891|ref|NP_217270.1| FAD-dependent thymidylate synthase ... 510 6e-143 gi|228312358|pdb|3GWC|A Chain A, Crystal Structure Of Mycobacter... 509 1e-142 gi|340627755|ref|YP_004746207.1| putative thymidylate synthase T... 504 3e-141 gi|78101336|pdb|2AF6|A Chain A, Crystal Structure Of Mycobacteri... 499 2e-139 gi|296171679|ref|ZP_06852893.1| thymidylate synthase (FAD) [Myco... 483 1e-134 gi|183981975|ref|YP_001850266.1| thymidylate synthase ThyX [Myco... 477 7e-133 gi|118617728|ref|YP_906060.1| FAD-dependent thymidylate synthase... 477 7e-133 gi|240171169|ref|ZP_04749828.1| FAD-dependent thymidylate syntha... 474 7e-132 gi|342858380|ref|ZP_08715035.1| FAD-dependent thymidylate syntha... 465 3e-129 gi|254821240|ref|ZP_05226241.1| FAD-dependent thymidylate syntha... 465 3e-129 gi|336458927|gb|EGO37882.1| thymidylate synthase, flavin-depende... 462 2e-128 gi|41408963|ref|NP_961799.1| FAD-dependent thymidylate synthase ... 462 3e-128 gi|120403377|ref|YP_953206.1| FAD-dependent thymidylate synthase... 447 5e-124 gi|118473148|ref|YP_887018.1| FAD-dependent thymidylate synthase... 447 5e-124 gi|145224582|ref|YP_001135260.1| FAD-dependent thymidylate synth... 436 1e-120 gi|315444913|ref|YP_004077792.1| thymidylate synthase (FAD) [Myc... 434 6e-120 gi|15827798|ref|NP_302061.1| FAD-dependent thymidylate synthase ... 426 2e-117 gi|169630168|ref|YP_001703817.1| FAD-dependent thymidylate synth... 421 7e-116 gi|333991144|ref|YP_004523758.1| thymidylate synthase ThyX [Myco... 419 2e-115 gi|108799082|ref|YP_639279.1| FAD-dependent thymidylate synthase... 414 5e-114 gi|126434688|ref|YP_001070379.1| FAD-dependent thymidylate synth... 413 1e-113 gi|262202122|ref|YP_003273330.1| thymidylate synthase, flavin-de... 409 2e-112 gi|343927023|ref|ZP_08766511.1| thymidylate synthase ThyX [Gordo... 404 9e-111 gi|333919314|ref|YP_004492895.1| Thymidylate synthase thyX [Amyc... 394 5e-108 gi|326384513|ref|ZP_08206193.1| FAD-dependent thymidylate syntha... 387 6e-106 gi|257056517|ref|YP_003134349.1| FAD-dependent thymidylate synth... 387 8e-106 gi|331698416|ref|YP_004334655.1| Thymidylate synthase thyX [Pseu... 383 1e-104 gi|111023704|ref|YP_706676.1| FAD-dependent thymidylate synthase... 383 2e-104 gi|325002561|ref|ZP_08123673.1| FAD-dependent thymidylate syntha... 382 3e-104 gi|226366141|ref|YP_002783924.1| FAD-dependent thymidylate synth... 382 3e-104 gi|134102349|ref|YP_001108010.1| FAD-dependent thymidylate synth... 378 5e-103 gi|319949592|ref|ZP_08023636.1| FAD-dependent thymidylate syntha... 372 3e-101 gi|226306218|ref|YP_002766178.1| FAD-dependent thymidylate synth... 372 4e-101 gi|229490913|ref|ZP_04384748.1| thymidylate synthase, flavin-dep... 371 6e-101 gi|238063402|ref|ZP_04608111.1| thymidylate synthase, flavin-dep... 371 6e-101 gi|300788150|ref|YP_003768441.1| FAD-dependent thymidylate synth... 370 7e-101 gi|302528513|ref|ZP_07280855.1| thymidylate synthase, flavin-dep... 369 2e-100 gi|302865989|ref|YP_003834626.1| thymidylate synthase, flavin-de... 369 2e-100 gi|256379809|ref|YP_003103469.1| FAD-dependent thymidylate synth... 369 3e-100 gi|291301738|ref|YP_003513016.1| thymidylate synthase flavin-dep... 367 1e-99 gi|330466381|ref|YP_004404124.1| FAD-dependent thymidylate synth... 366 2e-99 gi|325672768|ref|ZP_08152464.1| thymidylate synthase ThyX [Rhodo... 364 8e-99 gi|312139352|ref|YP_004006688.1| thymidylate synthase (fad) thyx... 363 2e-98 gi|111225102|ref|YP_715896.1| FAD-dependent thymidylate synthase... 360 1e-97 gi|288921713|ref|ZP_06415980.1| thymidylate synthase, flavin-dep... 359 3e-97 gi|312194997|ref|YP_004015058.1| thymidylate synthase, flavin-de... 356 2e-96 gi|86742228|ref|YP_482628.1| FAD-dependent thymidylate synthase ... 356 2e-96 gi|336179452|ref|YP_004584827.1| Thymidylate synthase thyX [Fran... 352 4e-95 gi|213964687|ref|ZP_03392887.1| thymidylate synthase, flavin-dep... 349 2e-94 >gi|308369848|ref|ZP_07419275.2| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu002] gi|308378089|ref|ZP_07481478.2| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu009] gi|308380464|ref|ZP_07490029.2| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu011] gi|308405962|ref|ZP_07494563.2| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu012] gi|308326195|gb|EFP15046.1| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu002] gi|308353569|gb|EFP42420.1| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu009] gi|308361365|gb|EFP50216.1| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu011] gi|308364974|gb|EFP53825.1| thymidylate synthase thyX [Mycobacterium tuberculosis SUMu012] Length=253 Score = 512 bits (1318), Expect = 2e-143, Method: Compositional matrix adjust. Identities = 250/250 (100%), Positives = 250/250 (100%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 4 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 63 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP Sbjct 64 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 123 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE Sbjct 124 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 183 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE Sbjct 184 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 243 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 244 VATSPLATEA 253 >gi|15609891|ref|NP_217270.1| FAD-dependent thymidylate synthase [Mycobacterium tuberculosis H37Rv] gi|15842292|ref|NP_337329.1| FAD-dependent thymidylate synthase [Mycobacterium tuberculosis CDC1551] gi|31793928|ref|NP_856421.1| FAD-dependent thymidylate synthase [Mycobacterium bovis AF2122/97] 73 more sequence titles Length=250 Score = 510 bits (1314), Expect = 6e-143, Method: Compositional matrix adjust. Identities = 249/250 (99%), Positives = 250/250 (100%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP Sbjct 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE Sbjct 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|228312358|pdb|3GWC|A Chain A, Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Synthase X Bound To Fdump And Fad gi|228312359|pdb|3GWC|B Chain B, Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Synthase X Bound To Fdump And Fad gi|228312360|pdb|3GWC|C Chain C, Crystal Structure Of Mycobacterium Tuberculosis Thymidylate Synthase X Bound To Fdump And Fad 9 more sequence titles Length=258 Score = 509 bits (1312), Expect = 1e-142, Method: Compositional matrix adjust. Identities = 249/250 (99%), Positives = 250/250 (100%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP Sbjct 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE Sbjct 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|340627755|ref|YP_004746207.1| putative thymidylate synthase THYX [Mycobacterium canettii CIPT 140010059] gi|340005945|emb|CCC45112.1| putative thymidylate synthase THYX (TS) (TSase) [Mycobacterium canettii CIPT 140010059] Length=250 Score = 504 bits (1299), Expect = 3e-141, Method: Compositional matrix adjust. Identities = 247/250 (99%), Positives = 248/250 (99%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP Sbjct 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQA QAARAVLPNATE Sbjct 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQACQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTL DGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLDDGTE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|78101336|pdb|2AF6|A Chain A, Crystal Structure Of Mycobacterium Tuberculosis Flavin Dependent Thymidylate Synthase (Mtb Thyx) In The Presence Of Co-Factor Fad And Substrate Analog 5-Bromo-2'- Deoxyuridine-5'-Monophosphate (Brdump) gi|78101337|pdb|2AF6|B Chain B, Crystal Structure Of Mycobacterium Tuberculosis Flavin Dependent Thymidylate Synthase (Mtb Thyx) In The Presence Of Co-Factor Fad And Substrate Analog 5-Bromo-2'- Deoxyuridine-5'-Monophosphate (Brdump) gi|78101338|pdb|2AF6|C Chain C, Crystal Structure Of Mycobacterium Tuberculosis Flavin Dependent Thymidylate Synthase (Mtb Thyx) In The Presence Of Co-Factor Fad And Substrate Analog 5-Bromo-2'- Deoxyuridine-5'-Monophosphate (Brdump) 9 more sequence titles Length=258 Score = 499 bits (1284), Expect = 2e-139, Method: Compositional matrix adjust. Identities = 245/249 (99%), Positives = 245/249 (99%), Gaps = 0/249 (0%) Query 2 AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYL 61 AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYL Sbjct 2 AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYL 61 Query 62 RHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPG 121 RHI DVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPG Sbjct 62 RHIXDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPG 121 Query 122 MEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATET 181 EDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAV PNATET Sbjct 122 XEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVXPNATET 181 Query 182 RIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEV 241 RIVVTGNYRAWRHFIA RASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEV Sbjct 182 RIVVTGNYRAWRHFIAXRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEV 241 Query 242 ATSPLATEA 250 ATSPLATEA Sbjct 242 ATSPLATEA 250 >gi|296171679|ref|ZP_06852893.1| thymidylate synthase (FAD) [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894040|gb|EFG73803.1| thymidylate synthase (FAD) [Mycobacterium parascrofulaceum ATCC BAA-614] Length=253 Score = 483 bits (1243), Expect = 1e-134, Method: Compositional matrix adjust. Identities = 232/250 (93%), Positives = 243/250 (98%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 VAETAPLRVQLIAKT+FLAPPDVPWTTDA+GGPAL EFAGRACYQSWSKPNPKTATNAGY Sbjct 4 VAETAPLRVQLIAKTEFLAPPDVPWTTDAEGGPALTEFAGRACYQSWSKPNPKTATNAGY 63 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 ++HIIDVGHFSVLEHASVSFYITGISRS THELIRHRHFSYSQLSQRYVPE DSRVVVPP Sbjct 64 IKHIIDVGHFSVLEHASVSFYITGISRSLTHELIRHRHFSYSQLSQRYVPEGDSRVVVPP 123 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDD D+R ILTEAADA+RATY+ELLA+LEAKFADQPNA+LRRKQARQAARAVLPNATE Sbjct 124 GMEDDPDVRRILTEAADASRATYAELLARLEAKFADQPNAVLRRKQARQAARAVLPNATE 183 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLA APAVFADFE++TLADGTE Sbjct 184 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAEAAPAVFADFEISTLADGTE 243 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 244 VATSPLATEA 253 >gi|183981975|ref|YP_001850266.1| thymidylate synthase ThyX [Mycobacterium marinum M] gi|254788966|sp|B2HKZ0.1|THYX_MYCMM RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|183175301|gb|ACC40411.1| thymidylate synthase ThyX [Mycobacterium marinum M] Length=250 Score = 477 bits (1228), Expect = 7e-133, Method: Compositional matrix adjust. Identities = 229/249 (92%), Positives = 241/249 (97%), Gaps = 0/249 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPLRVQLIAKT+FLAPPDVPWTTDADGG ALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAETAPLRVQLIAKTEFLAPPDVPWTTDADGGEALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGHF+VLEHASVSFYI+GISRSCTHELIRHRHFSYSQLSQRYVPE DSRVVVPP Sbjct 61 LRHIIDVGHFAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEGDSRVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G+EDD +LR IL AADA+RATY+ELL KLEA+FADQPNA+LRRKQARQAARAVLPNATE Sbjct 121 GLEDDPELREILIAAADASRATYTELLTKLEARFADQPNAVLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVV+GNYRAWRHFIAMRASEHADVEIRRLAIECLRQL AVAPAVFADFEVTTLADG+E Sbjct 181 TRIVVSGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLVAVAPAVFADFEVTTLADGSE 240 Query 241 VATSPLATE 249 VATSPLATE Sbjct 241 VATSPLATE 249 >gi|118617728|ref|YP_906060.1| FAD-dependent thymidylate synthase [Mycobacterium ulcerans Agy99] gi|118569838|gb|ABL04589.1| thymidylate synthase ThyX [Mycobacterium ulcerans Agy99] Length=253 Score = 477 bits (1227), Expect = 7e-133, Method: Compositional matrix adjust. Identities = 230/249 (93%), Positives = 240/249 (97%), Gaps = 0/249 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 VAETAPLRVQLIAKT+FLAPPDVPWTTDADGG ALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 4 VAETAPLRVQLIAKTEFLAPPDVPWTTDADGGEALVEFAGRACYQSWSKPNPKTATNAGY 63 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGHF+VLEHASVSFYI+GISRSCTHELIRHRHFSYSQLSQRYVPE DSRVVVPP Sbjct 64 LRHIIDVGHFAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEGDSRVVVPP 123 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G+EDD +LR IL AADA+RATY ELL KLEA+FADQPNA+LRRKQARQAARAVLPNATE Sbjct 124 GLEDDPELREILIAAADASRATYIELLTKLEARFADQPNAVLRRKQARQAARAVLPNATE 183 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVV+GNYRAWRHFIAMRASEHADVEIRRLAIECLRQL AVAPAVFADFEVTTLADG+E Sbjct 184 TRIVVSGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLVAVAPAVFADFEVTTLADGSE 243 Query 241 VATSPLATE 249 VATSPLATE Sbjct 244 VATSPLATE 252 >gi|240171169|ref|ZP_04749828.1| FAD-dependent thymidylate synthase [Mycobacterium kansasii ATCC 12478] Length=250 Score = 474 bits (1219), Expect = 7e-132, Method: Compositional matrix adjust. Identities = 228/250 (92%), Positives = 239/250 (96%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +A+TAPLRV LIAKT+FL PPDVPWTTDADGG ALVEFAGRACYQSWSKPNP+TATNAGY Sbjct 1 MAQTAPLRVHLIAKTEFLTPPDVPWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 L+HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPE DS+VVVPP Sbjct 61 LKHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEGDSQVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDD +L+ ILT AADA RATY+ELL KLEAKFADQPNA+LRRKQARQAARAVLPNATE Sbjct 121 GMEDDPELQQILTAAADAGRATYTELLTKLEAKFADQPNAVLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLA APAVFADFEVTTLADG+E Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLADSAPAVFADFEVTTLADGSE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|342858380|ref|ZP_08715035.1| FAD-dependent thymidylate synthase [Mycobacterium colombiense CECT 3035] gi|342134084|gb|EGT87264.1| FAD-dependent thymidylate synthase [Mycobacterium colombiense CECT 3035] Length=250 Score = 465 bits (1196), Expect = 3e-129, Method: Compositional matrix adjust. Identities = 228/250 (92%), Positives = 241/250 (97%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKTDFLAPPDVPW+TDADGGPALVEFAGRACYQSWSKPNP+TATNAGY Sbjct 1 MAEIAPLRVQLIAKTDFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPRTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 ++HIIDVGHFSVLEHAS SFYITG+SRS THELIRHRHFSYSQLSQRYVPEKDS VVVPP Sbjct 61 IKHIIDVGHFSVLEHASASFYITGVSRSLTHELIRHRHFSYSQLSQRYVPEKDSHVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDD +L+ IL AADA+RATY+ELLAKLEAKFADQPNA+LRRKQARQAARAVLPNATE Sbjct 121 GMEDDPELQQILAAAADASRATYTELLAKLEAKFADQPNAVLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLA VAPAVFADFE++TLADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAGVAPAVFADFEISTLADGTE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|254821240|ref|ZP_05226241.1| FAD-dependent thymidylate synthase [Mycobacterium intracellulare ATCC 13950] Length=250 Score = 465 bits (1196), Expect = 3e-129, Method: Compositional matrix adjust. Identities = 228/250 (92%), Positives = 240/250 (96%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKT+FLAPPDVPW+TDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAEIAPLRVQLIAKTEFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 ++HIIDVGHFSVLEHASVSFYITG+SRSCTHELIRHRHFSYSQLSQRYVPE DS VVVPP Sbjct 61 IKHIIDVGHFSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPETDSHVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 GMEDD +LR IL AADA+RATY+ELLAKLEAKFADQPNA+LRRKQARQAARAVLPNATE Sbjct 121 GMEDDPELRQILAAAADASRATYTELLAKLEAKFADQPNAVLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLA APAVFADFE++ LADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAGAAPAVFADFEISALADGTE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|336458927|gb|EGO37882.1| thymidylate synthase, flavin-dependent [Mycobacterium avium subsp. paratuberculosis S397] Length=251 Score = 462 bits (1190), Expect = 2e-128, Method: Compositional matrix adjust. Identities = 228/250 (92%), Positives = 242/250 (97%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 VAE APLRVQLIAKTDFLAPPDVPW+TDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 2 VAEIAPLRVQLIAKTDFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 61 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 ++HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPE DSRVVVPP Sbjct 62 IKHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSRVVVPP 121 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G++DD +L+ IL AADA+RATY+ELLA+LEAKFADQP+A+LRRKQARQAARAVLPNATE Sbjct 122 GLDDDPELQQILAAAADASRATYTELLARLEAKFADQPSAVLRRKQARQAARAVLPNATE 181 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLR+LA VAPAVFADFE+ TLADGTE Sbjct 182 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLADVAPAVFADFEIATLADGTE 241 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 242 VATSPLATEA 251 >gi|41408963|ref|NP_961799.1| FAD-dependent thymidylate synthase [Mycobacterium avium subsp. paratuberculosis K-10] gi|118464679|ref|YP_882822.1| FAD-dependent thymidylate synthase [Mycobacterium avium 104] gi|254776084|ref|ZP_05217600.1| FAD-dependent thymidylate synthase [Mycobacterium avium subsp. avium ATCC 25291] gi|62901339|sp|Q73VZ6.1|THYX_MYCPA RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|254788960|sp|A0QIT4.1|THYX_MYCA1 RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|41397322|gb|AAS05182.1| hypothetical protein MAP_2865c [Mycobacterium avium subsp. paratuberculosis K-10] gi|118165966|gb|ABK66863.1| thymidylate synthase, flavin-dependent [Mycobacterium avium 104] Length=250 Score = 462 bits (1188), Expect = 3e-128, Method: Compositional matrix adjust. Identities = 227/250 (91%), Positives = 242/250 (97%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKTDFLAPPDVPW+TDADGGPALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAEIAPLRVQLIAKTDFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 ++HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPE DSRVVVPP Sbjct 61 IKHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSRVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G++DD +L+ IL AADA+RATY+ELLA+LEAKFADQP+A+LRRKQARQAARAVLPNATE Sbjct 121 GLDDDPELQQILAAAADASRATYTELLARLEAKFADQPSAVLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLR+LA VAPAVFADFE+ TLADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLADVAPAVFADFEIATLADGTE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|120403377|ref|YP_953206.1| FAD-dependent thymidylate synthase [Mycobacterium vanbaalenii PYR-1] gi|254788971|sp|A1T7Q0.1|THYX_MYCVP RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|119956195|gb|ABM13200.1| thymidylate synthase (FAD) [Mycobacterium vanbaalenii PYR-1] Length=250 Score = 447 bits (1151), Expect = 5e-124, Method: Compositional matrix adjust. Identities = 214/249 (86%), Positives = 228/249 (92%), Gaps = 0/249 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKT+F APPDVPW+TDADGG ALVEFAGRACYQSW KPNP+TATNAGY Sbjct 1 MAEIAPLRVQLIAKTEFSAPPDVPWSTDADGGAALVEFAGRACYQSWDKPNPRTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 +RHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPE DS+VV PP Sbjct 61 VRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEHDSQVVAPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G+EDD +L I TEAADA RA Y+ELL +LEA+ ADQPNA LRRKQARQAARAVLPNATE Sbjct 121 GIEDDPELLEIFTEAADAGRAAYTELLTRLEARLADQPNATLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHAD+EIRRLAIECLRQL AP VF+DFE+ LADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIECLRQLVDAAPQVFSDFEIVVLADGTE 240 Query 241 VATSPLATE 249 VATSPLATE Sbjct 241 VATSPLATE 249 >gi|118473148|ref|YP_887018.1| FAD-dependent thymidylate synthase [Mycobacterium smegmatis str. MC2 155] gi|254788967|sp|A0QVT0.1|THYX_MYCS2 RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|118174435|gb|ABK75331.1| thymidylate synthase, flavin-dependent [Mycobacterium smegmatis str. MC2 155] Length=250 Score = 447 bits (1151), Expect = 5e-124, Method: Compositional matrix adjust. Identities = 214/250 (86%), Positives = 229/250 (92%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKT+F+APP VPW TDADGG AL EFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAEIAPLRVQLIAKTEFMAPPGVPWETDADGGEALTEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 + HIIDVGHFSVLEHASVSFYI+GISRS THELIRHRHFSYSQLSQRYVPE DS VVVPP Sbjct 61 ISHIIDVGHFSVLEHASVSFYISGISRSATHELIRHRHFSYSQLSQRYVPEHDSEVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G EDD +L I T A DA+RATY+ELL +LEAKFADQPNA+LRRKQARQAARAVLPNATE Sbjct 121 GFEDDPELVEIFTSAVDASRATYTELLKRLEAKFADQPNAVLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAI CLR+L VAPAVF+DF ++TLADG+E Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRELVTVAPAVFSDFVISTLADGSE 240 Query 241 VATSPLATEA 250 VATSPLATEA Sbjct 241 VATSPLATEA 250 >gi|145224582|ref|YP_001135260.1| FAD-dependent thymidylate synthase [Mycobacterium gilvum PYR-GCK] gi|254788964|sp|A4TCJ4.1|THYX_MYCGI RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|145217068|gb|ABP46472.1| thymidylate synthase (FAD) [Mycobacterium gilvum PYR-GCK] Length=250 Score = 436 bits (1122), Expect = 1e-120, Method: Compositional matrix adjust. Identities = 209/249 (84%), Positives = 226/249 (91%), Gaps = 0/249 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKT+F APPDV W+TDADGG ALVEFAGRACYQSWSKPNP+TATNA Y Sbjct 1 MAEIAPLRVQLIAKTEFSAPPDVEWSTDADGGAALVEFAGRACYQSWSKPNPRTATNATY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 +RHIIDVGHFSVLEHASVSFYITG+SRSCTHELIRHRHFSYSQLSQRYVPE D+ VV PP Sbjct 61 VRHIIDVGHFSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPENDAEVVAPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G+EDD +L + T A DA+RA Y+ELL +LEAK ADQ + LRRKQARQAARAVLPNATE Sbjct 121 GIEDDPELLALFTAATDASRAAYTELLNRLEAKLADQGTSTLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLR+L AVAP VF+DFE+T LADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLVAVAPQVFSDFEITALADGTE 240 Query 241 VATSPLATE 249 VATSPLATE Sbjct 241 VATSPLATE 249 >gi|315444913|ref|YP_004077792.1| thymidylate synthase (FAD) [Mycobacterium sp. Spyr1] gi|315263216|gb|ADT99957.1| thymidylate synthase (FAD) [Mycobacterium sp. Spyr1] Length=250 Score = 434 bits (1116), Expect = 6e-120, Method: Compositional matrix adjust. Identities = 208/249 (84%), Positives = 225/249 (91%), Gaps = 0/249 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE APLRVQLIAKT+F APPDV W+TDADGG ALVEFAGRACYQSWSKPNP+TATNA Y Sbjct 1 MAEIAPLRVQLIAKTEFSAPPDVEWSTDADGGAALVEFAGRACYQSWSKPNPRTATNATY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 +RHIIDVGHFSVLEHASVSFYITG+SRSCTHELIRHRHFSYSQLSQRYVPE D+ VV PP Sbjct 61 VRHIIDVGHFSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPENDAEVVAPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 G+EDD +L + T A DA+RA Y+ELL +LEAK ADQ + LRRKQARQAARAVLPNATE Sbjct 121 GIEDDPELLALFTAATDASRAAYTELLNRLEAKLADQGTSTLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLR+L VAP VF+DFE+T LADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLVEVAPQVFSDFEITALADGTE 240 Query 241 VATSPLATE 249 VATSPLATE Sbjct 241 VATSPLATE 249 >gi|15827798|ref|NP_302061.1| FAD-dependent thymidylate synthase [Mycobacterium leprae TN] gi|221230275|ref|YP_002503691.1| FAD-dependent thymidylate synthase [Mycobacterium leprae Br4923] gi|14916924|sp|Q9CBW3.1|THYX_MYCLE RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|254788965|sp|B8ZRR4.1|THYX_MYCLB RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|13093350|emb|CAC30465.1| putative mycobacteriophage protein [Mycobacterium leprae] gi|219933382|emb|CAR71609.1| putative mycobacteriophage protein [Mycobacterium leprae Br4923] Length=254 Score = 426 bits (1094), Expect = 2e-117, Method: Compositional matrix adjust. Identities = 207/254 (82%), Positives = 225/254 (89%), Gaps = 4/254 (1%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +A+ APLRVQLIAKT+FLAPPDV WTTDADGG ALVEFAGRACYQSWSKPNP+TATNA Y Sbjct 1 MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 ++HIIDVGH +VLEHASVSFYI+GISRSCTHELIRHRHFSYSQLSQRYVPEKD++VVVPP Sbjct 61 IKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFA----DQPNAILRRKQARQAARAVLP 176 MEDD +L+ IL A +A+RATY+ELL KL AK A+LRRKQARQAA AVLP Sbjct 121 DMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLP 180 Query 177 NATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLA 236 NA ETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAI CLR+L VAPAVFADFE+T LA Sbjct 181 NANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALA 240 Query 237 DGTEVATSPLATEA 250 DGTEVATSPLATEA Sbjct 241 DGTEVATSPLATEA 254 >gi|169630168|ref|YP_001703817.1| FAD-dependent thymidylate synthase [Mycobacterium abscessus ATCC 19977] gi|254788961|sp|B1MD42.1|THYX_MYCA9 RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|169242135|emb|CAM63163.1| Thymidylate synthase ThyX [Mycobacterium abscessus] Length=250 Score = 421 bits (1081), Expect = 7e-116, Method: Compositional matrix adjust. Identities = 197/250 (79%), Positives = 221/250 (89%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AE PLRVQLIAKTDF+APPD+ W+TDADGGPALVEFAGRACYQSWSKPNP+TATN Y Sbjct 1 MAEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRH+I+VGH SVLEHAS +FYITGISRSCTHELIRHRHFSYSQLSQR+VPE DS VV+PP Sbjct 61 LRHVIEVGHLSVLEHASATFYITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 +EDD +L ++ +A DA+RA Y ELL KLE+ AD PNA+LRRKQARQAAR+VLPNATE Sbjct 121 AVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNAVLRRKQARQAARSVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAI CLRQLA +AP++F DF++ TLADGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTE 240 Query 241 VATSPLATEA 250 VA SPL E Sbjct 241 VAISPLVYEG 250 >gi|333991144|ref|YP_004523758.1| thymidylate synthase ThyX [Mycobacterium sp. JDM601] gi|333487112|gb|AEF36504.1| thymidylate synthase ThyX [Mycobacterium sp. JDM601] Length=254 Score = 419 bits (1078), Expect = 2e-115, Method: Compositional matrix adjust. Identities = 213/253 (85%), Positives = 231/253 (92%), Gaps = 4/253 (1%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPL VQLIAKT+FL PPDV W+TDA+GG ALVEFAGRACYQSWSKPNP+TATNA Y Sbjct 1 MAETAPLGVQLIAKTEFLPPPDVAWSTDAEGGQALVEFAGRACYQSWSKPNPRTATNAAY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 L+HIIDVGHFSVLEHA VSFYITGISRS THELIRHRHFS+SQLSQRYVPE DSR+VVPP Sbjct 61 LKHIIDVGHFSVLEHAGVSFYITGISRSATHELIRHRHFSFSQLSQRYVPEPDSRIVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKF-ADQPN---AILRRKQARQAARAVLP 176 GM+DD +L+ IL EAADA+RA Y+ELLA+LEAKF ADQP A+LRRKQARQAARAVLP Sbjct 121 GMDDDPELQQILAEAADASRAAYAELLARLEAKFTADQPGEKMAVLRRKQARQAARAVLP 180 Query 177 NATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLA 236 NATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLA+ECLRQL +APA F DFE+T LA Sbjct 181 NATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAVECLRQLIGLAPAAFGDFEITALA 240 Query 237 DGTEVATSPLATE 249 DGTEVATSPLATE Sbjct 241 DGTEVATSPLATE 253 >gi|108799082|ref|YP_639279.1| FAD-dependent thymidylate synthase [Mycobacterium sp. MCS] gi|119868197|ref|YP_938149.1| FAD-dependent thymidylate synthase [Mycobacterium sp. KMS] gi|122382277|sp|Q1BA61.1|THYX_MYCSS RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|254788969|sp|A1UEV1.1|THYX_MYCSK RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|108769501|gb|ABG08223.1| thymidylate synthase (FAD) [Mycobacterium sp. MCS] gi|119694286|gb|ABL91359.1| thymidylate synthase (FAD) [Mycobacterium sp. KMS] Length=254 Score = 414 bits (1065), Expect = 5e-114, Method: Compositional matrix adjust. Identities = 211/254 (84%), Positives = 228/254 (90%), Gaps = 4/254 (1%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPLRVQLIA+T+F PPDVPW TDA+GG ALVEFAGRACYQSWSKPNP+TATNA Y Sbjct 1 MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHIIDVGH SVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPE DS+VVVPP Sbjct 61 LRHIIDVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKF-ADQP---NAILRRKQARQAARAVLP 176 G+E DA+L + T AADA+RA Y+ELLAKLEAK D+P A LRRKQARQAAR+VLP Sbjct 121 GIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLP 180 Query 177 NATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLA 236 NATETRIVVTGNYRAWRHFIAMRASEHAD+EIRRLAI CLR+L AVAPAVFADFE+ LA Sbjct 181 NATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLA 240 Query 237 DGTEVATSPLATEA 250 DGTEVAT+PL TEA Sbjct 241 DGTEVATTPLVTEA 254 >gi|126434688|ref|YP_001070379.1| FAD-dependent thymidylate synthase [Mycobacterium sp. JLS] gi|254788968|sp|A3PYB1.1|THYX_MYCSJ RecName: Full=Thymidylate synthase thyX; Short=TS; Short=TSase gi|126234488|gb|ABN97888.1| thymidylate synthase (FAD) [Mycobacterium sp. JLS] Length=254 Score = 413 bits (1061), Expect = 1e-113, Method: Compositional matrix adjust. Identities = 210/254 (83%), Positives = 228/254 (90%), Gaps = 4/254 (1%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AETAPLRVQLIA+T+F PPDVPW TDA+GG ALVEFAGRACYQSWSKPNP+TATNA Y Sbjct 1 MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHII+VGH SVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPE DS+VVVPP Sbjct 61 LRHIIEVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKF-ADQP---NAILRRKQARQAARAVLP 176 G+E DA+L + T AADA+RA Y+ELLAKLEAK D+P A LRRKQARQAAR+VLP Sbjct 121 GIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLP 180 Query 177 NATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLA 236 NATETRIVVTGNYRAWRHFIAMRASEHAD+EIRRLAI CLR+L AVAPAVFADFE+ LA Sbjct 181 NATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLA 240 Query 237 DGTEVATSPLATEA 250 DGTEVAT+PL TEA Sbjct 241 DGTEVATTPLVTEA 254 >gi|262202122|ref|YP_003273330.1| thymidylate synthase, flavin-dependent [Gordonia bronchialis DSM 43247] gi|262085469|gb|ACY21437.1| thymidylate synthase, flavin-dependent [Gordonia bronchialis DSM 43247] Length=250 Score = 409 bits (1051), Expect = 2e-112, Method: Compositional matrix adjust. Identities = 190/250 (76%), Positives = 215/250 (86%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 ++E PL+VQ++A T F P DVPW+TDADGG ALVEFAGRACYQSW KPNP+TATNAGY Sbjct 1 MSELVPLKVQMVAMTQFTPPADVPWSTDADGGEALVEFAGRACYQSWDKPNPRTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHI++VGH S+LEHASV+FYI+GISRSCTHELIRHRHFSYSQLSQR+VPE DS VV PP Sbjct 61 LRHILEVGHLSLLEHASVTFYISGISRSCTHELIRHRHFSYSQLSQRFVPEHDSNVVAPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + D +L + T A DA+RA Y+ELLA LEAKFAD PNAILRRKQARQAAR+VLPNATE Sbjct 121 AIVGDPELEAMFTAATDASRAAYTELLAALEAKFADVPNAILRRKQARQAARSVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 T+IVVTGNYRAWRHF+ MRA+EHADVEIR+LA+ECLRQL VAP VF DFE+ TLADGTE Sbjct 181 TKIVVTGNYRAWRHFVGMRATEHADVEIRQLAVECLRQLMRVAPTVFGDFEIGTLADGTE 240 Query 241 VATSPLATEA 250 VATSP E Sbjct 241 VATSPFVLEG 250 >gi|343927023|ref|ZP_08766511.1| thymidylate synthase ThyX [Gordonia alkanivorans NBRC 16433] gi|343763081|dbj|GAA13437.1| thymidylate synthase ThyX [Gordonia alkanivorans NBRC 16433] Length=250 Score = 404 bits (1037), Expect = 9e-111, Method: Compositional matrix adjust. Identities = 187/250 (75%), Positives = 212/250 (85%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 ++E PL+VQ++A T F P DVPW+TDA+GG ALVEFAGRACYQSW KPNP+TATNAGY Sbjct 1 MSELVPLKVQMVAMTQFTPPEDVPWSTDAEGGEALVEFAGRACYQSWDKPNPRTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHI++VGH S+LEHASV+FYI+GISRSCTHELIRHRHFSYSQLSQR+VPE DS VV PP Sbjct 61 LRHILEVGHLSLLEHASVTFYISGISRSCTHELIRHRHFSYSQLSQRFVPEHDSNVVAPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + D L + T A DA+R Y+ELL LEAKFAD PNAILRRKQARQAAR+VLPNATE Sbjct 121 AIVGDEHLEELFTAATDASREAYTELLDALEAKFADVPNAILRRKQARQAARSVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 T+IVVTGNYRAWRHF+ MRA+EHADVEIR+LA+ECLRQL VAP VF DFE+ TLADGTE Sbjct 181 TKIVVTGNYRAWRHFVGMRATEHADVEIRQLAVECLRQLMQVAPTVFGDFEIGTLADGTE 240 Query 241 VATSPLATEA 250 VATSP E Sbjct 241 VATSPFVLEG 250 >gi|333919314|ref|YP_004492895.1| Thymidylate synthase thyX [Amycolicicoccus subflavus DQS3-9A1] gi|333481535|gb|AEF40095.1| Thymidylate synthase thyX [Amycolicicoccus subflavus DQS3-9A1] Length=250 Score = 394 bits (1013), Expect = 5e-108, Method: Compositional matrix adjust. Identities = 180/248 (73%), Positives = 208/248 (84%), Gaps = 0/248 (0%) Query 3 ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLR 62 E PL+VQLIAKT+F AP D+PW TDADGG AL EFAGRACYQSW+KPNP+TATN GYLR Sbjct 3 EIVPLKVQLIAKTEFFAPSDIPWETDADGGEALAEFAGRACYQSWNKPNPRTATNLGYLR 62 Query 63 HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGM 122 HI++VGH SVLEH S +FYITGISRSCTHELIRHRHFSYSQLSQR+V E D+ +V PP + Sbjct 63 HILEVGHLSVLEHGSATFYITGISRSCTHELIRHRHFSYSQLSQRFVHEDDANIVAPPAI 122 Query 123 EDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETR 182 D +L +L++AA+ R Y ELL L+ KFA+ PNA+LRRKQARQAAR+VLPNATETR Sbjct 123 AGDPELEALLSKAAEVTREAYVELLEALQQKFAEMPNALLRRKQARQAARSVLPNATETR 182 Query 183 IVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVA 242 IVVTGNYRAWRHFI MRA+EHADVEIR LAIECLRQL +AP +F DF++ TL+DG+EVA Sbjct 183 IVVTGNYRAWRHFIGMRATEHADVEIRELAIECLRQLQKIAPNIFGDFDIGTLSDGSEVA 242 Query 243 TSPLATEA 250 TSP TE Sbjct 243 TSPFVTEG 250 >gi|326384513|ref|ZP_08206193.1| FAD-dependent thymidylate synthase [Gordonia neofelifaecis NRRL B-59395] gi|326196858|gb|EGD54052.1| FAD-dependent thymidylate synthase [Gordonia neofelifaecis NRRL B-59395] Length=249 Score = 387 bits (995), Expect = 6e-106, Method: Compositional matrix adjust. Identities = 182/250 (73%), Positives = 207/250 (83%), Gaps = 1/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 ++E PL+VQL+A T F AP +V W TD DGG AL+EFAGRACY+SW KPNP+TATNAGY Sbjct 1 MSELVPLKVQLVAATQFTAP-EVDWETDVDGGEALIEFAGRACYESWHKPNPRTATNAGY 59 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRH+++VGH S+ EHA+ +FYITGISRSCTHELIRHRHFSYSQLSQR+VPE DS VV PP Sbjct 60 LRHVLEVGHTSLFEHATCTFYITGISRSCTHELIRHRHFSYSQLSQRFVPEHDSNVVAPP 119 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + DA L + +A DAAR Y ELLA+LEAKF+D PNAILR KQARQAAR+VLPNATE Sbjct 120 AIRGDARLEELFVQATDAARKAYGELLAELEAKFSDVPNAILRHKQARQAARSVLPNATE 179 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFI MRA+EHADVEIR+LA+ECLRQL VAP F DFE+ LADGTE Sbjct 180 TRIVVTGNYRAWRHFIGMRATEHADVEIRQLAVECLRQLREVAPTAFGDFEIGELADGTE 239 Query 241 VATSPLATEA 250 VATSP E Sbjct 240 VATSPFVFEG 249 >gi|257056517|ref|YP_003134349.1| FAD-dependent thymidylate synthase [Saccharomonospora viridis DSM 43017] gi|256586389|gb|ACU97522.1| thymidylate synthase (FAD) [Saccharomonospora viridis DSM 43017] Length=250 Score = 387 bits (994), Expect = 8e-106, Method: Compositional matrix adjust. Identities = 189/250 (76%), Positives = 208/250 (84%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +AET +V+LIAKT+F P DVPWTTDADGG ALVEFAGRACYQSWSKPNPKTATNAGY Sbjct 1 MAETVAPKVRLIAKTEFFPPEDVPWTTDADGGQALVEFAGRACYQSWSKPNPKTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 L HII+VGH SVLEHASVSFYITGISRS THELIRHRHFSYSQLSQRYVPE+D+ V P Sbjct 61 LDHIIEVGHLSVLEHASVSFYITGISRSLTHELIRHRHFSYSQLSQRYVPERDAAFVEPD 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + +D +L A A+ Y+ELLAKLE KFAD PNA LRRKQARQAAR+VLPNATE Sbjct 121 VIANDPELHEKFLAATQASVDAYTELLAKLEEKFADAPNATLRRKQARQAARSVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRA+EHADVEIR LA+ECLRQL VA FADF ++TL DGTE Sbjct 181 TRIVVTGNYRAWRHFIAMRATEHADVEIRALAVECLRQLQKVAENAFADFTISTLPDGTE 240 Query 241 VATSPLATEA 250 VA+SP E+ Sbjct 241 VASSPKVAES 250 >gi|331698416|ref|YP_004334655.1| Thymidylate synthase thyX [Pseudonocardia dioxanivorans CB1190] gi|326953105|gb|AEA26802.1| Thymidylate synthase thyX [Pseudonocardia dioxanivorans CB1190] Length=250 Score = 383 bits (984), Expect = 1e-104, Method: Compositional matrix adjust. Identities = 179/248 (73%), Positives = 206/248 (84%), Gaps = 0/248 (0%) Query 3 ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLR 62 E PL VQL+AKT+F P DVPW+TDADGG AL EFAGRACYQSW+KPNP TATNAGYLR Sbjct 3 EIVPLGVQLVAKTEFFPPSDVPWSTDADGGQALAEFAGRACYQSWAKPNPATATNAGYLR 62 Query 63 HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGM 122 HI++VGH SVLEH +VSFY+TG+SRS THELIRHRHFSYSQLSQRYVPE+D+ +V P + Sbjct 63 HILEVGHLSVLEHGTVSFYLTGVSRSLTHELIRHRHFSYSQLSQRYVPERDAAMVEPAAI 122 Query 123 EDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETR 182 +D +L + EAA+A+ Y++LLA LE +FAD PNA LRRKQARQAARA+LPNATETR Sbjct 123 AEDPELHALFEEAAEASVKAYTDLLAGLEKRFADVPNATLRRKQARQAARAILPNATETR 182 Query 183 IVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVA 242 IVVTGNYRAWRHFIAMRASEHADVEIR LA+ECLRQL P VF DF++ L DGTE+A Sbjct 183 IVVTGNYRAWRHFIAMRASEHADVEIRELAVECLRQLQREVPNVFNDFDIQKLEDGTEIA 242 Query 243 TSPLATEA 250 +SP TE Sbjct 243 SSPYVTEG 250 >gi|111023704|ref|YP_706676.1| FAD-dependent thymidylate synthase [Rhodococcus jostii RHA1] gi|110823234|gb|ABG98518.1| thymidylate synthase (FAD) [Rhodococcus jostii RHA1] Length=250 Score = 383 bits (983), Expect = 2e-104, Method: Compositional matrix adjust. Identities = 179/248 (73%), Positives = 203/248 (82%), Gaps = 0/248 (0%) Query 3 ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLR 62 +T PLRVQL+AKT+F P D+PW TDADGG AL EFAGRACYQSWSKPNP+TATNAGYLR Sbjct 3 QTVPLRVQLVAKTEFFPPADIPWETDADGGEALAEFAGRACYQSWSKPNPRTATNAGYLR 62 Query 63 HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGM 122 H+++VGH SVLEH +VSFYITGISRSCTHELIRHRHFSYSQLSQR+V E D VVVPP + Sbjct 63 HLLEVGHESVLEHGTVSFYITGISRSCTHELIRHRHFSYSQLSQRFVRENDGNVVVPPAI 122 Query 123 EDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETR 182 D +L + +A DA+RA Y ELL LE K AD + LR KQARQAARAVLPNATETR Sbjct 123 AGDPELEELFAKATDASRAAYGELLEALETKLADTSSVPLRNKQARQAARAVLPNATETR 182 Query 183 IVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVA 242 +VVTGNYRAWRHF++MRA+EHADVEIRR+A+ECLRQL A AP VF DFEV DGTEVA Sbjct 183 VVVTGNYRAWRHFVSMRATEHADVEIRRVAVECLRQLQAAAPNVFGDFEVLVWGDGTEVA 242 Query 243 TSPLATEA 250 S + +A Sbjct 243 RSTFSADA 250 >gi|325002561|ref|ZP_08123673.1| FAD-dependent thymidylate synthase [Pseudonocardia sp. P1] Length=270 Score = 382 bits (981), Expect = 3e-104, Method: Compositional matrix adjust. Identities = 178/248 (72%), Positives = 206/248 (84%), Gaps = 0/248 (0%) Query 3 ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLR 62 +T PL VQL+AKT+F P DVPW+TDADGG AL EFAGRACYQSWSKPNP+TATNAGY+R Sbjct 23 QTVPLTVQLVAKTEFTPPADVPWSTDADGGQALAEFAGRACYQSWSKPNPRTATNAGYVR 82 Query 63 HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGM 122 HI++VGH SVLEH SVSFY+TGISRS THELIRHRHFSYSQLSQRYVPE+D+ +V P + Sbjct 83 HILEVGHLSVLEHGSVSFYLTGISRSLTHELIRHRHFSYSQLSQRYVPERDAAMVEPDVI 142 Query 123 EDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETR 182 DD +L + +A+ A + Y +LL LE +FAD PN LRRKQARQAAR+VLPNATET+ Sbjct 143 ADDPELHELFLQASADALSAYQKLLEGLEKRFADVPNGTLRRKQARQAARSVLPNATETK 202 Query 183 IVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVA 242 IVVTGNYRAWRHF+AMRASEHADVEIR LA+ECLRQL P VFADFE+ L DGTE+A Sbjct 203 IVVTGNYRAWRHFVAMRASEHADVEIRNLAVECLRQLQREVPNVFADFEIQKLDDGTEIA 262 Query 243 TSPLATEA 250 +SPL +E Sbjct 263 SSPLVSEG 270 >gi|226366141|ref|YP_002783924.1| FAD-dependent thymidylate synthase [Rhodococcus opacus B4] gi|226244631|dbj|BAH54979.1| FAD-dependent thymidylate synthase ThyX [Rhodococcus opacus B4] Length=250 Score = 382 bits (981), Expect = 3e-104, Method: Compositional matrix adjust. Identities = 178/248 (72%), Positives = 203/248 (82%), Gaps = 0/248 (0%) Query 3 ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLR 62 +T PLRVQL+AKT+F P D+PW TDADGG AL EFAGRACYQSWSKPNP+TATNAGYLR Sbjct 3 QTVPLRVQLVAKTEFFPPADIPWETDADGGEALAEFAGRACYQSWSKPNPRTATNAGYLR 62 Query 63 HIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGM 122 H+++VGH SVLEH +VSFYITGISRSCTHELIRHRHFSYSQLSQR+V E + VVVPP + Sbjct 63 HLLEVGHESVLEHGTVSFYITGISRSCTHELIRHRHFSYSQLSQRFVRENEGNVVVPPAI 122 Query 123 EDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETR 182 D +L + +A DA+R Y ELL LE+K AD N LR KQARQAARAVLPNATETR Sbjct 123 AGDPELEELFAKATDASRTAYGELLEALESKLADTSNVPLRNKQARQAARAVLPNATETR 182 Query 183 IVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVA 242 +VVTGNYRAWRHF++MRA+EHADVEIRR+A+ECLRQL A AP VF DFEV DGTEVA Sbjct 183 VVVTGNYRAWRHFVSMRATEHADVEIRRVAVECLRQLQASAPNVFGDFEVVDWGDGTEVA 242 Query 243 TSPLATEA 250 S + +A Sbjct 243 RSTFSADA 250 >gi|134102349|ref|YP_001108010.1| FAD-dependent thymidylate synthase [Saccharopolyspora erythraea NRRL 2338] gi|291003688|ref|ZP_06561661.1| FAD-dependent thymidylate synthase [Saccharopolyspora erythraea NRRL 2338] gi|133914972|emb|CAM05085.1| thymidylate synthase (TSase) [Saccharopolyspora erythraea NRRL 2338] Length=250 Score = 378 bits (970), Expect = 5e-103, Method: Compositional matrix adjust. Identities = 177/250 (71%), Positives = 204/250 (82%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 + E P +VQLI KT+F P DV W+TDADGG AL EFAGRACYQSW KPNP TATNAGY Sbjct 1 MTEIVPPKVQLIGKTEFFPPADVDWSTDADGGQALAEFAGRACYQSWRKPNPATATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHI++VGH SVLEH +V+FY++G+SRS THELIRHRHFSYSQLSQRYVPE+D+ +V P Sbjct 61 LRHILEVGHLSVLEHGTVTFYLSGMSRSLTHELIRHRHFSYSQLSQRYVPERDAAMVEPD 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + +D +L +A +A+ A YSELL L+ KFAD+P A LRRKQARQAAR+VLPNATE Sbjct 121 VIAEDPELHEKFVKATEASVAAYSELLEALQEKFADEPKATLRRKQARQAARSVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIR LAIECLRQL P VF DFE+T+L DG+E Sbjct 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRALAIECLRQLQKAVPNVFGDFEITSLKDGSE 240 Query 241 VATSPLATEA 250 VA+SP TE Sbjct 241 VASSPFVTEG 250 >gi|319949592|ref|ZP_08023636.1| FAD-dependent thymidylate synthase [Dietzia cinnamea P4] gi|319436743|gb|EFV91819.1| FAD-dependent thymidylate synthase [Dietzia cinnamea P4] Length=250 Score = 372 bits (955), Expect = 3e-101, Method: Compositional matrix adjust. Identities = 174/250 (70%), Positives = 205/250 (82%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 ++E +V+++A T+FL P +V W TDA+GG AL EFAGRACYQSW KPNP+TATNAGY Sbjct 1 MSELVRRQVRMVAHTEFLPPDEVGWETDAEGGSALAEFAGRACYQSWDKPNPRTATNAGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHI++VGH SV EHASV+FYITGISRSCTHELIRHRHFSYSQLSQR+VPE DS+VV PP Sbjct 61 LRHILEVGHLSVFEHASVTFYITGISRSCTHELIRHRHFSYSQLSQRFVPEHDSKVVPPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + DD +L I A DA+R Y+E+LA+LE +FAD PN +LR KQARQAAR+VLPNATE Sbjct 121 AIADDPELVEIFRRATDASRDAYAEMLARLEERFADVPNPMLRHKQARQAARSVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYR+WRHFI MRA+EHAD EIR LAI+ LRQL APAVF+DFE+ TL DG+E Sbjct 181 TRIVVTGNYRSWRHFIGMRATEHADTEIRGLAIDVLRQLREAAPAVFSDFEIATLEDGSE 240 Query 241 VATSPLATEA 250 +A SP E Sbjct 241 IAVSPYVLEG 250 >gi|226306218|ref|YP_002766178.1| FAD-dependent thymidylate synthase ThyX [Rhodococcus erythropolis PR4] gi|226185335|dbj|BAH33439.1| putative FAD-dependent thymidylate synthase ThyX [Rhodococcus erythropolis PR4] Length=250 Score = 372 bits (954), Expect = 4e-101, Method: Compositional matrix adjust. Identities = 172/247 (70%), Positives = 201/247 (82%), Gaps = 0/247 (0%) Query 4 TAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRH 63 T L+VQL+AK++F P D+PW TDADGG ALVEF+GRACYQSWSKPNP+TATNAGYLRH Sbjct 4 TVSLKVQLVAKSEFFPPEDIPWETDADGGEALVEFSGRACYQSWSKPNPRTATNAGYLRH 63 Query 64 IIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGME 123 +++VGH SVLEHA+VSFYITGISRSCTHELIRHRHFSYSQLSQR+V E D+ VVVPP +E Sbjct 64 LLEVGHVSVLEHATVSFYITGISRSCTHELIRHRHFSYSQLSQRFVRENDANVVVPPAVE 123 Query 124 DDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRI 183 D +L + A D +R Y ELL LE K P A +R KQARQAAR+VLPNATETR+ Sbjct 124 GDPELEALFLSATDESRRAYGELLTALEGKLQSVPGAPMRGKQARQAARSVLPNATETRL 183 Query 184 VVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVAT 243 VVTGNYRAWRHF+ MRA+EHADVEIRR+AIECLRQL VAP VF D+E+ +DG+E+A Sbjct 184 VVTGNYRAWRHFVEMRATEHADVEIRRVAIECLRQLRDVAPNVFGDYEILRGSDGSEIAV 243 Query 244 SPLATEA 250 S A E+ Sbjct 244 SAFAAES 250 >gi|229490913|ref|ZP_04384748.1| thymidylate synthase, flavin-dependent [Rhodococcus erythropolis SK121] gi|229322303|gb|EEN88089.1| thymidylate synthase, flavin-dependent [Rhodococcus erythropolis SK121] Length=250 Score = 371 bits (952), Expect = 6e-101, Method: Compositional matrix adjust. Identities = 171/247 (70%), Positives = 201/247 (82%), Gaps = 0/247 (0%) Query 4 TAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRH 63 T L+VQL+AK++F P D+PW TDADGG ALVEF+GRACYQSWSKPNP+TATNAGYLRH Sbjct 4 TVSLKVQLVAKSEFFPPEDIPWETDADGGEALVEFSGRACYQSWSKPNPRTATNAGYLRH 63 Query 64 IIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGME 123 +++VGH SVLEHA+VSFYITGISRSCTHELIRHRHFSYSQLSQR+V E D+ VVVPP +E Sbjct 64 LLEVGHVSVLEHATVSFYITGISRSCTHELIRHRHFSYSQLSQRFVRENDANVVVPPAVE 123 Query 124 DDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRI 183 D +L + A D +R Y ELL LE K P A +R KQARQAAR+VLPNATETR+ Sbjct 124 GDPELEALFLNATDESRRAYGELLTALEGKLQSVPGAPMRGKQARQAARSVLPNATETRL 183 Query 184 VVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVAT 243 VVTGNYRAWRHF+ MRA+EHADVEIRR+A+ECLRQL VAP VF D+E+ +DG+E+A Sbjct 184 VVTGNYRAWRHFVEMRATEHADVEIRRVAVECLRQLRDVAPNVFGDYEILRGSDGSEIAV 243 Query 244 SPLATEA 250 S A E+ Sbjct 244 SAFAAES 250 >gi|238063402|ref|ZP_04608111.1| thymidylate synthase, flavin-dependent [Micromonospora sp. ATCC 39149] gi|237885213|gb|EEP74041.1| thymidylate synthase, flavin-dependent [Micromonospora sp. ATCC 39149] Length=247 Score = 371 bits (952), Expect = 6e-101, Method: Compositional matrix adjust. Identities = 178/240 (75%), Positives = 200/240 (84%), Gaps = 0/240 (0%) Query 8 RVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDV 67 +V+L+A T F AP DVPW+TDA+GG AL EFAGRACYQSWSKPNP TATNAGYL HI+ V Sbjct 5 QVKLVAWTQFQAPEDVPWSTDAEGGQALAEFAGRACYQSWSKPNPATATNAGYLAHILQV 64 Query 68 GHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDAD 127 GH SVLEH SVSFY TG+SRS THELIRHRH SYSQLSQRYVPE+D+ +V P + +D + Sbjct 65 GHLSVLEHGSVSFYFTGVSRSFTHELIRHRHLSYSQLSQRYVPERDAAMVEPRVIAEDPE 124 Query 128 LRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTG 187 L EAADA+ Y+ELL LE +FAD+PN LRRKQARQAARAVLPNATETRIVVTG Sbjct 125 LHKRFVEAADASVRAYTELLEGLEQRFADEPNPTLRRKQARQAARAVLPNATETRIVVTG 184 Query 188 NYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLA 247 NYRAWRHF+AMRA+EHADVEIR LA+ECLRQL VAP VFADF ++TL DGTEVA SPLA Sbjct 185 NYRAWRHFVAMRATEHADVEIRELAVECLRQLQRVAPNVFADFVISTLPDGTEVAASPLA 244 >gi|300788150|ref|YP_003768441.1| FAD-dependent thymidylate synthase [Amycolatopsis mediterranei U32] gi|299797664|gb|ADJ48039.1| FAD-dependent thymidylate synthase [Amycolatopsis mediterranei U32] gi|340529735|gb|AEK44940.1| FAD-dependent thymidylate synthase [Amycolatopsis mediterranei S699] Length=250 Score = 370 bits (951), Expect = 7e-101, Method: Compositional matrix adjust. Identities = 180/243 (75%), Positives = 196/243 (81%), Gaps = 0/243 (0%) Query 8 RVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDV 67 RVQLIAKT+F P DVPW+TDADGG AL EFAGRACYQSW KPNP TATNAGYL HIIDV Sbjct 8 RVQLIAKTEFFPPGDVPWSTDADGGEALAEFAGRACYQSWKKPNPATATNAGYLEHIIDV 67 Query 68 GHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDAD 127 GH SVLEH SV+FYITGISRS THELIRHRHFSYSQLSQRYVPE D+ V P + +D Sbjct 68 GHLSVLEHGSVTFYITGISRSLTHELIRHRHFSYSQLSQRYVPECDAEFVEPEIIANDPV 127 Query 128 LRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTG 187 L A A+ Y+ELL+ LE KFAD P+A LRRKQARQAARAVLPNATETRIVVTG Sbjct 128 LHEKFLAATRASVEAYTELLSGLEEKFADVPSATLRRKQARQAARAVLPNATETRIVVTG 187 Query 188 NYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLA 247 NYRAWRHF+AMRA+EHADVEIR LA+ECLRQL A VFADF ++TL DGTE+ATSP Sbjct 188 NYRAWRHFVAMRATEHADVEIRELAVECLRQLQKAAANVFADFTISTLPDGTEIATSPKV 247 Query 248 TEA 250 E Sbjct 248 LEG 250 >gi|302528513|ref|ZP_07280855.1| thymidylate synthase, flavin-dependent [Streptomyces sp. AA4] gi|302437408|gb|EFL09224.1| thymidylate synthase, flavin-dependent [Streptomyces sp. AA4] Length=246 Score = 369 bits (948), Expect = 2e-100, Method: Compositional matrix adjust. Identities = 179/245 (74%), Positives = 197/245 (81%), Gaps = 0/245 (0%) Query 6 PLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHII 65 P +VQLIAKT+F P DVPW+TDADGG AL EFAGRACYQSW KPNP TATNAGYL H+I Sbjct 2 PPKVQLIAKTEFFPPEDVPWSTDADGGEALAEFAGRACYQSWEKPNPATATNAGYLEHVI 61 Query 66 DVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDD 125 DVGH +VLEH SV+FY TGISRS THELIRHRHFSYSQLS+RYVPE D+ V P + +D Sbjct 62 DVGHLAVLEHGSVTFYFTGISRSLTHELIRHRHFSYSQLSRRYVPEADAEFVEPDVIAED 121 Query 126 ADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVV 185 L +A A+ A Y ELLA LE KFAD P+A LRRKQARQAARAVLPNATETRIVV Sbjct 122 PVLHEKFVKATQASAAAYDELLAGLEEKFADAPSATLRRKQARQAARAVLPNATETRIVV 181 Query 186 TGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSP 245 TGNYRAWRHFIAMRA+EHADVEIR LAIECLRQL A VFADF ++TL DGTE+A+SP Sbjct 182 TGNYRAWRHFIAMRATEHADVEIRSLAIECLRQLHKAAANVFADFTISTLPDGTEIASSP 241 Query 246 LATEA 250 E Sbjct 242 KVLEG 246 >gi|302865989|ref|YP_003834626.1| thymidylate synthase, flavin-dependent [Micromonospora aurantiaca ATCC 27029] gi|315502549|ref|YP_004081436.1| thymidylate synthase, flavin-dependent [Micromonospora sp. L5] gi|302568848|gb|ADL45050.1| thymidylate synthase, flavin-dependent [Micromonospora aurantiaca ATCC 27029] gi|315409168|gb|ADU07285.1| thymidylate synthase, flavin-dependent [Micromonospora sp. L5] Length=245 Score = 369 bits (947), Expect = 2e-100, Method: Compositional matrix adjust. Identities = 176/240 (74%), Positives = 198/240 (83%), Gaps = 0/240 (0%) Query 8 RVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDV 67 +V+LIA T F AP +VPW+TDADGG AL EFAGRACYQSW KPNP TATNAGYL HI++V Sbjct 5 QVKLIAWTQFQAPEEVPWSTDADGGQALAEFAGRACYQSWKKPNPATATNAGYLAHILEV 64 Query 68 GHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDAD 127 GH SVLEH SVSFY +G+SRS THELIRHRHFSYSQLSQRYVPE+D+ +V P + DD + Sbjct 65 GHLSVLEHGSVSFYFSGVSRSFTHELIRHRHFSYSQLSQRYVPERDAAMVEPSVIADDPE 124 Query 128 LRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTG 187 L EA DAA Y+ELL LEA+F D+PN LRRKQARQAARAVLPNATETRIVVTG Sbjct 125 LHKKFVEATDAAVRAYTELLEGLEARFTDEPNPTLRRKQARQAARAVLPNATETRIVVTG 184 Query 188 NYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLA 247 NYRAWRHF+ MRA+EHADVEIR LA+ECLRQL VAP VFADF ++TL DG+EVA SP A Sbjct 185 NYRAWRHFVKMRATEHADVEIRELAVECLRQLKGVAPNVFADFVISTLPDGSEVAASPHA 244 >gi|256379809|ref|YP_003103469.1| FAD-dependent thymidylate synthase [Actinosynnema mirum DSM 43827] gi|255924112|gb|ACU39623.1| thymidylate synthase, flavin-dependent [Actinosynnema mirum DSM 43827] Length=250 Score = 369 bits (947), Expect = 3e-100, Method: Compositional matrix adjust. Identities = 182/250 (73%), Positives = 205/250 (82%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 +A+T VQLIAKT+F P DVPW+TDA+GG AL EFAGRACYQSWSKPNP TATN Y Sbjct 1 MAQTVSPHVQLIAKTEFFPPSDVPWSTDAEGGEALAEFAGRACYQSWSKPNPATATNEAY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHII+VGH SVLEH SVSFYITGISRS THELIRHRHFSYSQLSQRYVPE+D+ +V P Sbjct 61 LRHIIEVGHLSVLEHGSVSFYITGISRSLTHELIRHRHFSYSQLSQRYVPERDAAMVEPE 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + +D +L AA+A+ A Y++LL LE KF+D P+A LRRKQARQAARAVLPNATE Sbjct 121 VIANDPELHARFLAAAEASVAAYNDLLKGLEEKFSDVPSATLRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TR+VVTGNYRAWRHFIAMRA+EHADVEIR LAIECLR L AP FADF +T+LADGTE Sbjct 181 TRLVVTGNYRAWRHFIAMRATEHADVEIRALAIECLRHLQKAAPGAFADFAITSLADGTE 240 Query 241 VATSPLATEA 250 VA+SPL E Sbjct 241 VASSPLVAEG 250 >gi|291301738|ref|YP_003513016.1| thymidylate synthase flavin-dependent [Stackebrandtia nassauensis DSM 44728] gi|290570958|gb|ADD43923.1| thymidylate synthase, flavin-dependent [Stackebrandtia nassauensis DSM 44728] Length=250 Score = 367 bits (941), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 176/243 (73%), Positives = 200/243 (83%), Gaps = 0/243 (0%) Query 8 RVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDV 67 +V +IA T F AP DVPW+TDADGG AL EFAGRACYQSW+KPNPKTATNAGYL HI+ V Sbjct 8 QVTIIAWTHFEAPEDVPWSTDADGGQALAEFAGRACYQSWNKPNPKTATNAGYLDHILQV 67 Query 68 GHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDAD 127 GH SVLEH SVSFY+TGISRS THELIRHRHFSYSQLSQRYVPE+D+++V P + D D Sbjct 68 GHLSVLEHGSVSFYLTGISRSLTHELIRHRHFSYSQLSQRYVPERDAQMVEPDVIAADPD 127 Query 128 LRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTG 187 L AADA++ Y+ELL LE KFA++PNA LRRKQARQAARAVLPNATETRIVVTG Sbjct 128 LHEKFLAAADASQRAYTELLEGLEKKFAEEPNATLRRKQARQAARAVLPNATETRIVVTG 187 Query 188 NYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLA 247 NYRAWRHFIAMRASEHADVEIR LA+ CL++L P V ADF +++L+DGTEVA+SP Sbjct 188 NYRAWRHFIAMRASEHADVEIRALAVTCLKRLKEKVPNVVADFSISSLSDGTEVASSPYV 247 Query 248 TEA 250 E Sbjct 248 HEG 250 >gi|330466381|ref|YP_004404124.1| FAD-dependent thymidylate synthase [Verrucosispora maris AB-18-032] gi|328809352|gb|AEB43524.1| FAD-dependent thymidylate synthase [Verrucosispora maris AB-18-032] Length=250 Score = 366 bits (939), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 177/243 (73%), Positives = 200/243 (83%), Gaps = 0/243 (0%) Query 8 RVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDV 67 +V+LIA T F P DVPW+TDADGG AL EFAGRACYQSW KPNP TATNAGYL HI++V Sbjct 8 QVRLIAWTHFEPPQDVPWSTDADGGQALAEFAGRACYQSWKKPNPATATNAGYLAHILEV 67 Query 68 GHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDAD 127 GH SVLEH SVSFY TG+SRS THELIRHRHFSYSQLSQRYVPE+D+ +V P + +D + Sbjct 68 GHLSVLEHGSVSFYFTGVSRSFTHELIRHRHFSYSQLSQRYVPERDAAMVEPRVIAEDPE 127 Query 128 LRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTG 187 L EAA+A+ Y+ELL LE F D+PN LRRKQARQAARAVLPNATETRIVV+G Sbjct 128 LHKRFVEAAEASVRAYNELLEGLERHFVDEPNPTLRRKQARQAARAVLPNATETRIVVSG 187 Query 188 NYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLA 247 NYRAWRHFIAMRA+EHADVEIR LA+ECLRQL VAP VFADF ++TL DGTEVA SPLA Sbjct 188 NYRAWRHFIAMRATEHADVEIRELAVECLRQLQRVAPNVFADFVISTLPDGTEVAASPLA 247 Query 248 TEA 250 ++ Sbjct 248 EQS 250 >gi|325672768|ref|ZP_08152464.1| thymidylate synthase ThyX [Rhodococcus equi ATCC 33707] gi|325556645|gb|EGD26311.1| thymidylate synthase ThyX [Rhodococcus equi ATCC 33707] Length=250 Score = 364 bits (934), Expect = 8e-99, Method: Compositional matrix adjust. Identities = 175/242 (73%), Positives = 203/242 (84%), Gaps = 0/242 (0%) Query 6 PLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHII 65 PL+VQL+AKT+F P D+PW TDADGG AL EFAGRACYQSWSKPNP+TATNAGYLRH++ Sbjct 6 PLKVQLVAKTEFFPPSDIPWQTDADGGEALAEFAGRACYQSWSKPNPRTATNAGYLRHLL 65 Query 66 DVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDD 125 +VGH SVLEH SVSFYI+GISRSCTHELIRHRHFSYSQLSQR+V E D+ VV+PP + D Sbjct 66 EVGHLSVLEHGSVSFYISGISRSCTHELIRHRHFSYSQLSQRFVRENDANVVIPPAIAGD 125 Query 126 ADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVV 185 A L + ++A +A+R Y+ELL LE K AD+PN +R KQARQAAR+VLPNATETR+VV Sbjct 126 ARLEALFSKATEASRGAYAELLEALEEKLADEPNGPVRNKQARQAARSVLPNATETRVVV 185 Query 186 TGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSP 245 TGNYRAWRHF+ MRA+EHADVEIR +AIECLRQL AP VF DFE+ TL DG+EVATS Sbjct 186 TGNYRAWRHFVEMRATEHADVEIRHVAIECLRQLQVAAPNVFGDFEIVTLPDGSEVATSE 245 Query 246 LA 247 A Sbjct 246 FA 247 >gi|312139352|ref|YP_004006688.1| thymidylate synthase (fad) thyx [Rhodococcus equi 103S] gi|311888691|emb|CBH48003.1| putative thymidylate synthase (FAD) ThyX [Rhodococcus equi 103S] Length=250 Score = 363 bits (931), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 175/242 (73%), Positives = 202/242 (84%), Gaps = 0/242 (0%) Query 6 PLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHII 65 PL+VQL+AKT+F P D+PW TDADGG AL EFAGRACYQSWSKPNP+TATNAGYLRH++ Sbjct 6 PLKVQLVAKTEFFPPSDIPWETDADGGEALAEFAGRACYQSWSKPNPRTATNAGYLRHLL 65 Query 66 DVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDD 125 +VGH SVLEH SVSFYI+GISRSCTHELIRHRHFSYSQLSQR+V E D+ VV+PP + D Sbjct 66 EVGHLSVLEHGSVSFYISGISRSCTHELIRHRHFSYSQLSQRFVRENDANVVIPPAIAGD 125 Query 126 ADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVV 185 A L + +A +A+R Y+ELL LE K AD+PN +R KQARQAAR+VLPNATETR+VV Sbjct 126 ARLEALFAKATEASRGAYAELLEALEEKLADEPNGPVRNKQARQAARSVLPNATETRVVV 185 Query 186 TGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSP 245 TGNYRAWRHF+ MRA+EHADVEIR +AIECLRQL AP VF DFE+ TL DG+EVATS Sbjct 186 TGNYRAWRHFVEMRATEHADVEIRHVAIECLRQLQVAAPNVFGDFEIVTLPDGSEVATSE 245 Query 246 LA 247 A Sbjct 246 FA 247 >gi|111225102|ref|YP_715896.1| FAD-dependent thymidylate synthase [Frankia alni ACN14a] gi|111152634|emb|CAJ64375.1| Thymidylate synthase (TSase) [Frankia alni ACN14a] Length=257 Score = 360 bits (923), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 174/244 (72%), Positives = 198/244 (82%), Gaps = 0/244 (0%) Query 7 LRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIID 66 LRVQ+IAKT+FL P DVPW+TDADGG AL EFAGRACYQSWSKPNP TATNAGYLRHI+D Sbjct 14 LRVQVIAKTEFLPPADVPWSTDADGGQALAEFAGRACYQSWSKPNPATATNAGYLRHILD 73 Query 67 VGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDA 126 VGH SVLEH +VS Y+TG+SRS THEL+RHRHFSYSQLSQRYVPE+D+ +V P + D Sbjct 74 VGHLSVLEHGTVSLYLTGVSRSLTHELVRHRHFSYSQLSQRYVPERDAAIVEPEVVAGDP 133 Query 127 DLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVT 186 +L + +AA A+ Y LL LE +FAD RRKQARQAAR+VL NATETRIVVT Sbjct 134 ELHALFEQAAAASLEAYGRLLEGLEKRFADIAAPTSRRKQARQAARSVLLNATETRIVVT 193 Query 187 GNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPL 246 GNYRAWRHFIAMRASEHADVEIR LA+ LR+L AVAP VF+DF ++TL DGTEVA+SPL Sbjct 194 GNYRAWRHFIAMRASEHADVEIRGLAVAILRELHAVAPNVFSDFRISTLDDGTEVASSPL 253 Query 247 ATEA 250 E Sbjct 254 VGEG 257 >gi|288921713|ref|ZP_06415980.1| thymidylate synthase, flavin-dependent [Frankia sp. EUN1f] gi|288346885|gb|EFC81195.1| thymidylate synthase, flavin-dependent [Frankia sp. EUN1f] Length=278 Score = 359 bits (921), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 182/250 (73%), Positives = 201/250 (81%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 V A LRVQ+IA+T+FL P DVPW+TDADGG AL EFAGRACYQSWSKPNP TATNAGY Sbjct 29 VPAAARLRVQVIARTEFLPPSDVPWSTDADGGQALAEFAGRACYQSWSKPNPATATNAGY 88 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRHI+DVGH SVLEH SVS YITG+SRS THEL+RHRHFSYSQLSQRYVPE D+ +V P Sbjct 89 LRHILDVGHLSVLEHGSVSLYITGVSRSLTHELVRHRHFSYSQLSQRYVPEHDAALVEPE 148 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + DD +L + TEAA A+ Y+ LL LE +FAD RRKQARQAAR+VL NATE Sbjct 149 VIADDPELHELFTEAAAASMEAYARLLEGLEKRFADVSAPTSRRKQARQAARSVLMNATE 208 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGNYRAWRHFIAMRASEHADVEIR LA+ LR L VAP VFADF+V TL DGTE Sbjct 209 TRIVVTGNYRAWRHFIAMRASEHADVEIRGLAVAILRALREVAPNVFADFQVRTLDDGTE 268 Query 241 VATSPLATEA 250 VA+SPLA E Sbjct 269 VASSPLAGEG 278 >gi|312194997|ref|YP_004015058.1| thymidylate synthase, flavin-dependent [Frankia sp. EuI1c] gi|311226333|gb|ADP79188.1| thymidylate synthase, flavin-dependent [Frankia sp. EuI1c] Length=244 Score = 356 bits (914), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 174/244 (72%), Positives = 197/244 (81%), Gaps = 0/244 (0%) Query 7 LRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIID 66 +RVQ+IA+T+FL P DVPW TDADGG AL EFAGRACYQSW+KPNP TATNAGYLRHI+D Sbjct 1 MRVQVIARTEFLPPADVPWETDADGGQALAEFAGRACYQSWNKPNPATATNAGYLRHILD 60 Query 67 VGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDA 126 VGH SVLEH +V+ YITG+SRS THEL+RHRHFSYSQLSQRYVPE+D+ +V P + D Sbjct 61 VGHLSVLEHGTVTLYITGVSRSLTHELVRHRHFSYSQLSQRYVPERDAEMVEPEVVAADP 120 Query 127 DLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVT 186 +L + EAA A+ YS+LL LE FA+ RRKQARQAAR+VLPNATETRIVVT Sbjct 121 ELHALFQEAAAASLEAYSKLLEGLEKHFAEVAAPTSRRKQARQAARSVLPNATETRIVVT 180 Query 187 GNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPL 246 GNYRAWRHFIAMRASE ADVEIR LAI LR L VAP VFADF V+TL DGTEVA+SPL Sbjct 181 GNYRAWRHFIAMRASESADVEIRGLAILALRALQDVAPNVFADFRVSTLDDGTEVASSPL 240 Query 247 ATEA 250 +E Sbjct 241 VSEG 244 >gi|86742228|ref|YP_482628.1| FAD-dependent thymidylate synthase [Frankia sp. CcI3] gi|86569090|gb|ABD12899.1| thymidylate synthase (FAD) [Frankia sp. CcI3] Length=265 Score = 356 bits (914), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 172/244 (71%), Positives = 196/244 (81%), Gaps = 0/244 (0%) Query 7 LRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIID 66 LRVQ+IAKT+F+ P DV W+TDADGG AL EFAGRACYQSW+KPNP TATNAGYLRHI+D Sbjct 22 LRVQVIAKTEFIPPDDVAWSTDADGGQALAEFAGRACYQSWNKPNPATATNAGYLRHILD 81 Query 67 VGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDA 126 VGH SVLEH +VS Y+TG+SRS THEL+RHRHFSYSQLSQRYVPE+D+ VV P + D Sbjct 82 VGHLSVLEHGTVSLYLTGVSRSLTHELVRHRHFSYSQLSQRYVPERDAAVVEPEVIAADP 141 Query 127 DLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVT 186 +L + +AA A+ Y LL LE +FAD I RRKQARQAAR+VL NATETRIVVT Sbjct 142 ELHALFQQAAAASLEAYGRLLEGLEKRFADVSAPISRRKQARQAARSVLMNATETRIVVT 201 Query 187 GNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPL 246 GNYRAWRHFI MRASEHADVEIR LA+ LR+L VAP VFADF ++TL DGTEVA+SPL Sbjct 202 GNYRAWRHFIGMRASEHADVEIRGLAVAVLRELLRVAPNVFADFRISTLDDGTEVASSPL 261 Query 247 ATEA 250 E Sbjct 262 VGEG 265 >gi|336179452|ref|YP_004584827.1| Thymidylate synthase thyX [Frankia symbiont of Datisca glomerata] gi|334860432|gb|AEH10906.1| Thymidylate synthase thyX [Frankia symbiont of Datisca glomerata] Length=244 Score = 352 bits (902), Expect = 4e-95, Method: Compositional matrix adjust. Identities = 171/241 (71%), Positives = 194/241 (81%), Gaps = 0/241 (0%) Query 7 LRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIID 66 +RVQ+IA+T F+ P DV W+TDADGG AL EFAGRACYQSWSKPNP TATNAGYLRHI+D Sbjct 3 MRVQIIAQTQFVPPDDVDWSTDADGGQALAEFAGRACYQSWSKPNPATATNAGYLRHILD 62 Query 67 VGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDA 126 VGH SVLEHA+VS YITG+SRS THEL+RHRHFSYSQLSQRYVPE+D+ V+ P + +D Sbjct 63 VGHLSVLEHATVSVYITGVSRSLTHELVRHRHFSYSQLSQRYVPERDAAVIEPDVIAEDP 122 Query 127 DLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVT 186 L + TEA A+ Y +LL LE +FAD RRK ARQAAR+VLPNATETRIVVT Sbjct 123 RLHELFTEATAASLEAYGKLLEGLEKRFADVATPTSRRKLARQAARSVLPNATETRIVVT 182 Query 187 GNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPL 246 GNYRAWRHFIAMRASE ADVEIR LA+ LR+L +AP VF DF+VT L DGTEVA SPL Sbjct 183 GNYRAWRHFIAMRASEAADVEIRALAVAVLRELQRLAPNVFGDFQVTALDDGTEVAASPL 242 Query 247 A 247 A Sbjct 243 A 243 >gi|213964687|ref|ZP_03392887.1| thymidylate synthase, flavin-dependent [Corynebacterium amycolatum SK46] gi|213952880|gb|EEB64262.1| thymidylate synthase, flavin-dependent [Corynebacterium amycolatum SK46] Length=250 Score = 349 bits (895), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 159/250 (64%), Positives = 195/250 (78%), Gaps = 0/250 (0%) Query 1 VAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGY 60 ++E L+ QLIA T+F P D+ + TDADGG AL+EF+GRACY++W KPNP+TATN GY Sbjct 1 MSENVTLKAQLIAATNFFPPEDIDFDTDADGGEALIEFSGRACYETWDKPNPRTATNRGY 60 Query 61 LRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPP 120 LRH+++VGH S+ EHA+ S Y+ G+SRSC HEL RHRHFS+SQLSQR+VP + VVVPP Sbjct 61 LRHVLEVGHTSLFEHANASIYVRGLSRSCAHELTRHRHFSFSQLSQRFVPASSNNVVVPP 120 Query 121 GMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATE 180 + +D DL + A D +R Y ELL LE K+AD+PNAILRRKQARQAARAVLPNATE Sbjct 121 AIGEDPDLLRVFESAVDQSRFAYGELLDALEEKWADEPNAILRRKQARQAARAVLPNATE 180 Query 181 TRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTE 240 TRIVVTGN+R+WRHFI+MRA+EHAD EIR LA+ CLR+L AP F DFE+ TL DG+ Sbjct 181 TRIVVTGNFRSWRHFISMRATEHADAEIRELAVACLRELQRCAPVAFGDFEINTLKDGSV 240 Query 241 VATSPLATEA 250 VA+SP A E Sbjct 241 VASSPYAFEG 250 Lambda K H 0.320 0.131 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 358945203960 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40