BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2763c Length=159 Score E Sequences producing significant alignments: (Bits) Value gi|254232861|ref|ZP_04926188.1| dihydrofolate reductase dfrA (te... 321 2e-86 gi|253798155|ref|YP_003031156.1| dihydrofolate reductase dfrA [M... 321 2e-86 gi|15609900|ref|NP_217279.1| dihydrofolate reductase DFRA (DHFR)... 321 3e-86 gi|99031974|pdb|2CIG|A Chain A, Dihydrofolate Reductase From Myc... 319 1e-85 gi|289762935|ref|ZP_06522313.1| dihydrofolate reductase dfrA (te... 293 4e-78 gi|118617726|ref|YP_906058.1| dihydrofolate reductase DfrA [Myco... 237 5e-61 gi|240171164|ref|ZP_04749823.1| putative dihydrofolate reductase... 235 2e-60 gi|15827800|ref|NP_302063.1| dihydrofolate reductase [Mycobacter... 230 4e-59 gi|333991149|ref|YP_004523763.1| dihydrofolate reductase DfrA [M... 227 3e-58 gi|296171673|ref|ZP_06852887.1| dihydrofolate reductase [Mycobac... 224 4e-57 gi|342858375|ref|ZP_08715030.1| dihydrofolate reductase [Mycobac... 224 4e-57 gi|254776087|ref|ZP_05217603.1| DfrA [Mycobacterium avium subsp.... 221 3e-56 gi|145224586|ref|YP_001135264.1| dihydrofolate reductase [Mycoba... 221 3e-56 gi|2586159|gb|AAC45841.1| dihydrofolate reductase [Mycobacterium... 221 3e-56 gi|41408966|ref|NP_961802.1| DfrA [Mycobacterium avium subsp. pa... 221 3e-56 gi|108799080|ref|YP_639277.1| dihydrofolate reductase [Mycobacte... 220 4e-56 gi|268612134|pdb|2W3V|A Chain A, Mycobacterium Avium Dihydrofola... 220 4e-56 gi|119868195|ref|YP_938147.1| dihydrofolate reductase [Mycobacte... 220 5e-56 gi|118466885|ref|YP_882828.1| dihydrofolate reductase [Mycobacte... 219 8e-56 gi|126434686|ref|YP_001070377.1| dihydrofolate reductase [Mycoba... 219 8e-56 gi|254821237|ref|ZP_05226238.1| dihydrofolate reductase [Mycobac... 219 1e-55 gi|120403372|ref|YP_953201.1| dihydrofolate reductase [Mycobacte... 217 5e-55 gi|118474019|ref|YP_887008.1| dihydrofolate reductase [Mycobacte... 204 4e-51 gi|169630172|ref|YP_001703821.1| dihydrofolate reductase DfrA [M... 181 4e-44 gi|302556751|ref|ZP_07309093.1| dihydrofolate reductase [Strepto... 168 2e-40 gi|332670063|ref|YP_004453071.1| dihydrofolate reductase region ... 168 3e-40 gi|226361377|ref|YP_002779155.1| dihydrofolate reductase [Rhodoc... 167 4e-40 gi|54026997|ref|YP_121239.1| putative dihydrofolate reductase [N... 166 1e-39 gi|296129375|ref|YP_003636625.1| Dihydrofolate reductase [Cellul... 163 7e-39 gi|325676380|ref|ZP_08156059.1| dihydrofolate reductase [Rhodoco... 163 1e-38 gi|111019242|ref|YP_702214.1| dihydrofolate reductase [Rhodococc... 162 1e-38 gi|229495093|ref|ZP_04388839.1| dihydrofolate reductase [Rhodoco... 162 1e-38 gi|229821346|ref|YP_002882872.1| Dihydrofolate reductase [Beuten... 162 1e-38 gi|50954681|ref|YP_061969.1| dihydrofolate reductase [Leifsonia ... 162 2e-38 gi|226307949|ref|YP_002767909.1| dihydrofolate reductase [Rhodoc... 161 4e-38 gi|312138556|ref|YP_004005892.1| dihydrofolate reductase [Rhodoc... 161 4e-38 gi|271966277|ref|YP_003340473.1| dihydrofolate reductase [Strept... 160 4e-38 gi|296139475|ref|YP_003646718.1| dihydrofolate reductase [Tsukam... 160 5e-38 gi|334338010|ref|YP_004543162.1| dihydrofolate reductase [Isopte... 159 1e-37 gi|317508367|ref|ZP_07966040.1| dihydrofolate reductase [Segnili... 157 6e-37 gi|222110328|ref|YP_002552592.1| dihydrofolate reductase [Acidov... 154 3e-36 gi|330824058|ref|YP_004387361.1| dihydrofolate reductase [Alicyc... 154 4e-36 gi|319763677|ref|YP_004127614.1| dihydrofolate reductase [Alicyc... 154 4e-36 gi|152968377|ref|YP_001364161.1| dihydrofolate reductase [Kineoc... 154 6e-36 gi|326384523|ref|ZP_08206203.1| dihydrofolate reductase region [... 153 7e-36 gi|336287822|gb|AEI30195.1| dihydrofolate reductase [uncultured ... 153 7e-36 gi|319792494|ref|YP_004154134.1| dihydrofolate reductase region ... 152 2e-35 gi|337279087|ref|YP_004618558.1| dihydrofolate reductase [Ramlib... 151 3e-35 gi|91787701|ref|YP_548653.1| dihydrofolate reductase [Polaromona... 151 3e-35 gi|296394395|ref|YP_003659279.1| dihydrofolate reductase region ... 151 3e-35 >gi|254232861|ref|ZP_04926188.1| dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase) [Mycobacterium tuberculosis C] gi|124601920|gb|EAY60930.1| dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase) [Mycobacterium tuberculosis C] Length=164 Score = 321 bits (822), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 159/159 (100%), Positives = 159/159 (100%), Gaps = 0/159 (0%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR Sbjct 6 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 65 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP Sbjct 66 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 125 Query 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS Sbjct 126 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 164 >gi|253798155|ref|YP_003031156.1| dihydrofolate reductase dfrA [Mycobacterium tuberculosis KZN 1435] gi|254365414|ref|ZP_04981459.1| dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase) [Mycobacterium tuberculosis str. Haarlem] gi|254551822|ref|ZP_05142269.1| dihydrofolate reductase dfrA [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] 9 more sequence titles Length=161 Score = 321 bits (822), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 159/159 (100%), Positives = 159/159 (100%), Gaps = 0/159 (0%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR Sbjct 3 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 62 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP Sbjct 63 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 122 Query 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS Sbjct 123 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 161 >gi|15609900|ref|NP_217279.1| dihydrofolate reductase DFRA (DHFR) (tetrahydrofolate dehydrogenase) [Mycobacterium tuberculosis H37Rv] gi|15842301|ref|NP_337338.1| dihydrofolate reductase [Mycobacterium tuberculosis CDC1551] gi|31793938|ref|NP_856431.1| dihydrofolate reductase [Mycobacterium bovis AF2122/97] 70 more sequence titles Length=159 Score = 321 bits (822), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 159/159 (100%), Positives = 159/159 (100%), Gaps = 0/159 (0%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR Sbjct 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP Sbjct 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 Query 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS Sbjct 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 >gi|99031974|pdb|2CIG|A Chain A, Dihydrofolate Reductase From Mycobacterium Tuberculosis Inhibited By The Acyclic 4r Isomer Of Inh-Nadp A Derivative Of The Prodrug Isoniazid. Length=159 Score = 319 bits (817), Expect = 1e-85, Method: Compositional matrix adjust. Identities = 158/159 (99%), Positives = 158/159 (99%), Gaps = 0/159 (0%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRR WDSLPAKVRPLPGR Sbjct 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRVWDSLPAKVRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP Sbjct 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 Query 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS Sbjct 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 >gi|289762935|ref|ZP_06522313.1| dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase) [Mycobacterium tuberculosis GM 1503] gi|289710441|gb|EFD74457.1| dihydrofolate reductase dfrA (tetrahydrofolate dehydrogenase) [Mycobacterium tuberculosis GM 1503] Length=146 Score = 293 bits (751), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 146/146 (100%), Positives = 146/146 (100%), Gaps = 0/146 (0%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR Sbjct 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP Sbjct 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 Query 121 REAGDALAPVLDETWRGETGEWRFSR 146 REAGDALAPVLDETWRGETGEWRFSR Sbjct 121 REAGDALAPVLDETWRGETGEWRFSR 146 >gi|118617726|ref|YP_906058.1| dihydrofolate reductase DfrA [Mycobacterium ulcerans Agy99] gi|183981971|ref|YP_001850262.1| dihydrofolate reductase DfrA [Mycobacterium marinum M] gi|118569836|gb|ABL04587.1| dihydrofolate reductase DfrA [Mycobacterium ulcerans Agy99] gi|183175297|gb|ACC40407.1| dihydrofolate reductase DfrA [Mycobacterium marinum M] Length=165 Score = 237 bits (604), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 117/161 (73%), Positives = 132/161 (82%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGLIWAQ+TSGVIGR G IPWRLPED AHF+ +TMGHT+VMGRRTWDSLPA RPLPGRR Sbjct 4 VGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSLPAAHRPLPGRR 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALT----SPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVV++RQ +A GA+VVGSLE+AL ETWVIGG Q+YALALP A RCEVTEVD+ Sbjct 64 NVVVTRQTGLVAHGAQVVGSLEQALCPAEPDAETWVIGGAQIYALALPLANRCEVTEVDV 123 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 LP E DALAPVLD+TW G +GEW SRSGLRYR++SY R Sbjct 124 DLPPEDEDALAPVLDQTWAGTSGEWLVSRSGLRYRMHSYRR 164 >gi|240171164|ref|ZP_04749823.1| putative dihydrofolate reductase [Mycobacterium kansasii ATCC 12478] Length=158 Score = 235 bits (599), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 122/158 (78%), Positives = 138/158 (88%), Gaps = 1/158 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GLIWAQ+TSGVIGRGGDIPWR+PED +HF+ ITMGHT+VMGRRTWDSLPA RPLPGRR Sbjct 1 MGLIWAQSTSGVIGRGGDIPWRVPEDLSHFKRITMGHTVVMGRRTWDSLPASARPLPGRR 60 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPE-TWVIGGGQVYALALPYATRCEVTEVDIGLP 120 NVVLSRQ F+A GAEVVGSLE+ALT PE TWVIGG Q+Y LALP A RCEVTEVD+ LP Sbjct 61 NVVLSRQPGFVAEGAEVVGSLEDALTGPEDTWVIGGEQIYTLALPRAIRCEVTEVDVDLP 120 Query 121 REAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 R+ DALAP LDETW+G+ GEW+ SRSGLRYR +SY+R Sbjct 121 RDDDDALAPPLDETWQGDVGEWQVSRSGLRYRFHSYYR 158 >gi|15827800|ref|NP_302063.1| dihydrofolate reductase [Mycobacterium leprae TN] gi|221230277|ref|YP_002503693.1| dihydrofolate reductase [Mycobacterium leprae Br4923] gi|18202766|sp|Q9CBW1.1|DYR_MYCLE RecName: Full=Dihydrofolate reductase gi|13093352|emb|CAC30469.1| dihydrofolate reductase [Mycobacterium leprae] gi|219933384|emb|CAR71613.1| dihydrofolate reductase [Mycobacterium leprae Br4923] Length=165 Score = 230 bits (587), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 115/163 (71%), Positives = 129/163 (80%), Gaps = 4/163 (2%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 +VGLIWAQ+T+GVIGR G +PWR+PED F+++TMGH +VMGRRTWDSLP VRPLPGR Sbjct 3 VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62 Query 61 RNVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVD 116 RN+VLSRQ DFMA GAEV GSLEE + T PE WVIGG Q+Y LALP ATRC VTEVD Sbjct 63 RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122 Query 117 IGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 L E D LAPVLD+TW G TGEW S SGLRYRL+SYHRS Sbjct 123 TYLLHEDDDVLAPVLDDTWVGVTGEWLVSCSGLRYRLHSYHRS 165 >gi|333991149|ref|YP_004523763.1| dihydrofolate reductase DfrA [Mycobacterium sp. JDM601] gi|333487117|gb|AEF36509.1| dihydrofolate reductase DfrA [Mycobacterium sp. JDM601] Length=160 Score = 227 bits (579), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 111/157 (71%), Positives = 129/157 (83%), Gaps = 0/157 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GLIWAQ+TSGVIGR G IPWRLPEDQA F+E+T+GH +VMGR TW+SLPA VRPLPGR Sbjct 4 LGLIWAQSTSGVIGRDGGIPWRLPEDQARFKELTLGHRVVMGRLTWESLPAGVRPLPGRA 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPR 121 NVV+SR++D+ A GAEVV +L+ ALT ETWVIGG Q+YALALP A RCEVTEV+I LPR Sbjct 64 NVVVSRRSDYRAVGAEVVPTLDAALTDAETWVIGGAQIYALALPLADRCEVTEVEIDLPR 123 Query 122 EAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 + DA+APVLDE+WRG G W S GLRYR SYHR Sbjct 124 QDEDAVAPVLDESWRGTAGPWLTSARGLRYRFCSYHR 160 >gi|296171673|ref|ZP_06852887.1| dihydrofolate reductase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894034|gb|EFG73797.1| dihydrofolate reductase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=165 Score = 224 bits (571), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 117/162 (73%), Positives = 139/162 (86%), Gaps = 4/162 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ+TSG+IGRGGDIPWR+PED A F+++TMGHT++MGRRTW+SLPA VRPLPGR+ Sbjct 4 VGLVWAQSTSGIIGRGGDIPWRVPEDLARFKQVTMGHTVIMGRRTWESLPAAVRPLPGRK 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALTS----PETWVIGGGQVYALALPYATRCEVTEVDI 117 NVVLSR+ DF+A GA+VVGSLE AL PE WVIGG QVY LALP+ATRCEVTEVD+ Sbjct 64 NVVLSRRGDFVADGAQVVGSLEAALADCEGEPEAWVIGGEQVYLLALPHATRCEVTEVDV 123 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 L R+ DALAPVLD+ W GETGEW+ SR+GLRYRL+SY R+ Sbjct 124 DLRRDDDDALAPVLDDAWLGETGEWQVSRTGLRYRLHSYRRA 165 >gi|342858375|ref|ZP_08715030.1| dihydrofolate reductase [Mycobacterium colombiense CECT 3035] gi|342134079|gb|EGT87259.1| dihydrofolate reductase [Mycobacterium colombiense CECT 3035] Length=174 Score = 224 bits (570), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 114/161 (71%), Positives = 134/161 (84%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ+TSGVIGRGGDIPW +PED + F+E+T+GH ++MGRRTWDSLPAKVRPLPGRR Sbjct 4 VGLVWAQSTSGVIGRGGDIPWNVPEDLSRFKEVTIGHPVIMGRRTWDSLPAKVRPLPGRR 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALTS----PETWVIGGGQVYALALPYATRCEVTEVDI 117 N+VLSR A F+A GA+V G+L+EAL PE WVIGG Q+Y LALPYATRCEVTE++I Sbjct 64 NIVLSRDAGFVADGAQVAGTLDEALAHGADGPEAWVIGGEQIYLLALPYATRCEVTEIEI 123 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD+TW GETGEW SRSGLRYR +SY R Sbjct 124 DLRRDDDDALAPTLDDTWVGETGEWLASRSGLRYRFHSYRR 164 >gi|254776087|ref|ZP_05217603.1| DfrA [Mycobacterium avium subsp. avium ATCC 25291] Length=181 Score = 221 bits (563), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 113/161 (71%), Positives = 133/161 (83%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ+TSGVIGRGGDIPW +PED F+E+TMGHT++MGRRTW+SLPAKVRPLPGRR Sbjct 6 VGLVWAQSTSGVIGRGGDIPWNVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVV+SR+ DF+A GA V GSLE AL + P WVIGG Q+Y LALP+ATRCEVTE++I Sbjct 66 NVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 125 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD++W GETGEW SRSGLRYR +SY R Sbjct 126 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 166 >gi|145224586|ref|YP_001135264.1| dihydrofolate reductase [Mycobacterium gilvum PYR-GCK] gi|315444917|ref|YP_004077796.1| dihydrofolate reductase [Mycobacterium sp. Spyr1] gi|145217072|gb|ABP46476.1| Dihydrofolate reductase [Mycobacterium gilvum PYR-GCK] gi|315263220|gb|ADT99961.1| dihydrofolate reductase [Mycobacterium sp. Spyr1] Length=160 Score = 221 bits (563), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 107/158 (68%), Positives = 127/158 (81%), Gaps = 1/158 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 + LIWAQ++SGVIGR G IPW +PED A F+E+TMGHT++MGR+TW+SLP K RPLPGRR Sbjct 4 LNLIWAQSSSGVIGRDGGIPWHVPEDMARFKELTMGHTVIMGRQTWESLPEKFRPLPGRR 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPR 121 NVVL+RQAD++A GAEVV +LE+A + WVIGG QVY LALP ATRCE+TEVD+ L R Sbjct 64 NVVLTRQADYVAEGAEVVTALEDAPLD-DAWVIGGSQVYGLALPLATRCEITEVDLDLHR 122 Query 122 EAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 + DALAP+LDE W G GEWR S SGLRYR YSY R Sbjct 123 QDEDALAPLLDEAWVGTEGEWRDSASGLRYRFYSYVRK 160 >gi|2586159|gb|AAC45841.1| dihydrofolate reductase [Mycobacterium avium] Length=181 Score = 221 bits (562), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 113/161 (71%), Positives = 133/161 (83%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ+TSGVIGRGGDIPW +PED F+E+TMGHT++MGRRTW+SLPAKVRPLPGRR Sbjct 6 VGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVV+SR+ DF+A GA V GSLE AL + P WVIGG Q+Y LALP+ATRCEVTE++I Sbjct 66 NVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 125 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD++W GETGEW SRSGLRYR +SY R Sbjct 126 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 166 >gi|41408966|ref|NP_961802.1| DfrA [Mycobacterium avium subsp. paratuberculosis K-10] gi|41397325|gb|AAS05185.1| DfrA [Mycobacterium avium subsp. paratuberculosis K-10] gi|336458978|gb|EGO37932.1| dihydrofolate reductase [Mycobacterium avium subsp. paratuberculosis S397] Length=181 Score = 221 bits (562), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 113/161 (71%), Positives = 133/161 (83%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ+TSGVIGRGGDIPW +PED F+E+TMGHT++MGRRTW+SLPAKVRPLPGRR Sbjct 6 VGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVV+SR+ DF+A GA V GSLE AL + P WVIGG Q+Y LALP+ATRCEVTE++I Sbjct 66 NVVVSRRPDFVAEGARVAGSLEAALAHAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 125 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD++W GETGEW SRSGLRYR +SY R Sbjct 126 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 166 >gi|108799080|ref|YP_639277.1| dihydrofolate reductase [Mycobacterium sp. MCS] gi|108769499|gb|ABG08221.1| Dihydrofolate reductase [Mycobacterium sp. MCS] Length=167 Score = 220 bits (561), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 110/158 (70%), Positives = 127/158 (81%), Gaps = 0/158 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGLIWAQ+TSGVIGR G IPW LPED A F+EIT+GH +VMGR TW+SLP KVRPLPGR+ Sbjct 10 VGLIWAQSTSGVIGRDGGIPWHLPEDLARFKEITLGHPVVMGRLTWESLPPKVRPLPGRK 69 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPR 121 NVVL+RQAD+MA GAEVV SL++AL ETWVIGG +VY LAL ATRCEVTEV+I L R Sbjct 70 NVVLTRQADYMAEGAEVVTSLDDALGDEETWVIGGERVYTLALGRATRCEVTEVEIELHR 129 Query 122 EAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 + DA+APVL E W G G+W S SGLRYR +SY R+ Sbjct 130 QDADAVAPVLGEAWVGTAGDWLTSVSGLRYRFHSYQRA 167 >gi|268612134|pdb|2W3V|A Chain A, Mycobacterium Avium Dihydrofolate Reductase Complexed With Nadph And Trimethoprim gi|268612135|pdb|2W3W|A Chain A, Mycobacterium Avium Dihydrofolate Reductase Complexed With Nadph And A Lipophilic Antifolate Selective For M. Avium Dhfr, 6-((2,5-Diethoxyphenyl)aminomethyl)-2,4-Diamino-5- Methylpyrido(2,3-D)pyrimidine (Sri-8686) Length=167 Score = 220 bits (561), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 113/161 (71%), Positives = 133/161 (83%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ+TSGVIGRGGDIPW +PED F+E+TMGHT++MGRRTW+SLPAKVRPLPGRR Sbjct 6 VGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVV+SR+ DF+A GA V GSLE AL + P WVIGG Q+Y LALP+ATRCEVTE++I Sbjct 66 NVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 125 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD++W GETGEW SRSGLRYR +SY R Sbjct 126 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 166 >gi|119868195|ref|YP_938147.1| dihydrofolate reductase [Mycobacterium sp. KMS] gi|119694284|gb|ABL91357.1| Dihydrofolate reductase [Mycobacterium sp. KMS] Length=161 Score = 220 bits (560), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 110/158 (70%), Positives = 127/158 (81%), Gaps = 0/158 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGLIWAQ+TSGVIGR G IPW LPED A F+EIT+GH +VMGR TW+SLP KVRPLPGR+ Sbjct 4 VGLIWAQSTSGVIGRDGGIPWHLPEDLARFKEITLGHPVVMGRLTWESLPPKVRPLPGRK 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPR 121 NVVL+RQAD+MA GAEVV SL++AL ETWVIGG +VY LAL ATRCEVTEV+I L R Sbjct 64 NVVLTRQADYMAEGAEVVTSLDDALGDEETWVIGGERVYTLALGRATRCEVTEVEIELHR 123 Query 122 EAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 + DA+APVL E W G G+W S SGLRYR +SY R+ Sbjct 124 QDADAVAPVLGEAWVGTAGDWLTSVSGLRYRFHSYQRA 161 >gi|118466885|ref|YP_882828.1| dihydrofolate reductase [Mycobacterium avium 104] gi|118168172|gb|ABK69069.1| dihydrofolate reductase [Mycobacterium avium 104] Length=176 Score = 219 bits (559), Expect = 8e-56, Method: Compositional matrix adjust. Identities = 112/161 (70%), Positives = 133/161 (83%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GL+WAQ+TSGVIGRGGDIPW +PED F+E+TMGHT++MGRRTW+SLPAKVRPLPGRR Sbjct 1 MGLVWAQSTSGVIGRGGDIPWNVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRPLPGRR 60 Query 62 NVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVV+SR+ DF+A GA V GSLE AL + P WVIGG Q+Y LALP+ATRCEVTE++I Sbjct 61 NVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEVTEIEI 120 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD++W GETGEW SRSGLRYR +SY R Sbjct 121 DLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRR 161 >gi|126434686|ref|YP_001070377.1| dihydrofolate reductase [Mycobacterium sp. JLS] gi|126234486|gb|ABN97886.1| Dihydrofolate reductase [Mycobacterium sp. JLS] Length=161 Score = 219 bits (559), Expect = 8e-56, Method: Compositional matrix adjust. Identities = 109/158 (69%), Positives = 127/158 (81%), Gaps = 0/158 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGLIWAQ+TSGVIGR G IPW LPED A F+EIT+GH +VMGR TW+SLP KVRPLPGR+ Sbjct 4 VGLIWAQSTSGVIGRDGGIPWHLPEDLARFKEITLGHPVVMGRLTWESLPPKVRPLPGRK 63 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPR 121 NVVL+RQAD+MA GAEVV SL++AL ETWVIGG ++Y LAL ATRCEVTEV+I L R Sbjct 64 NVVLTRQADYMAEGAEVVTSLDDALGDEETWVIGGERIYTLALGRATRCEVTEVEIELHR 123 Query 122 EAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 + DA+APVL E W G G+W S SGLRYR +SY R+ Sbjct 124 QDADAVAPVLGEAWVGTAGDWLTSVSGLRYRFHSYQRA 161 >gi|254821237|ref|ZP_05226238.1| dihydrofolate reductase [Mycobacterium intracellulare ATCC 13950] Length=161 Score = 219 bits (558), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 114/161 (71%), Positives = 132/161 (82%), Gaps = 4/161 (2%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GL+WAQ+TSGVIGRGG IPW +PED A F+E+T+GHT+VMGRRTWDSLPAKVRPLPGRR Sbjct 1 MGLVWAQSTSGVIGRGGGIPWNVPEDLARFKEVTIGHTVVMGRRTWDSLPAKVRPLPGRR 60 Query 62 NVVLSRQADFMASGAEVVGSLEEALT----SPETWVIGGGQVYALALPYATRCEVTEVDI 117 NVVLSR+ F A GA+VVGSL+ A P WVIGGGQVY ALPYATRCEVTE+++ Sbjct 61 NVVLSREDGFAADGAQVVGSLDAAFAGAEGEPAVWVIGGGQVYLAALPYATRCEVTEIEL 120 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 L R+ DALAP LD+TW GETGEW+ SRSGLRYR +SY R Sbjct 121 DLRRDDDDALAPALDDTWVGETGEWQASRSGLRYRFHSYRR 161 >gi|120403372|ref|YP_953201.1| dihydrofolate reductase [Mycobacterium vanbaalenii PYR-1] gi|119956190|gb|ABM13195.1| Dihydrofolate reductase [Mycobacterium vanbaalenii PYR-1] Length=162 Score = 217 bits (552), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 104/158 (66%), Positives = 124/158 (79%), Gaps = 1/158 (0%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 + ++WAQ++SGVIGRG IPW +PED A F+E+TMGHT++MGR TW+SLPAK RPLPGRR Sbjct 6 LNMVWAQSSSGVIGRGDAIPWHVPEDMARFKELTMGHTVIMGRLTWESLPAKFRPLPGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPR 121 NVV++RQA + A GAEVV S E+A + WVIGG Q+Y LALP ATRCE+TEVDI L R Sbjct 66 NVVVTRQAGYQADGAEVVTSFEDAPLD-DAWVIGGSQIYGLALPLATRCEITEVDIDLRR 124 Query 122 EAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 E DALAPVLDE W G G+WR S SGLRYR YS+ R Sbjct 125 EDDDALAPVLDEAWVGTEGDWRDSSSGLRYRFYSFVRK 162 >gi|118474019|ref|YP_887008.1| dihydrofolate reductase [Mycobacterium smegmatis str. MC2 155] gi|118175306|gb|ABK76202.1| dihydrofolate reductase [Mycobacterium smegmatis str. MC2 155] Length=154 Score = 204 bits (519), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 100/155 (65%), Positives = 118/155 (77%), Gaps = 3/155 (1%) Query 4 LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV 63 LIWAQ+TSG+IGR IPWRLPED A F+E+TMGH +VMGR TW+SLPA VRPLPGRRN+ Sbjct 3 LIWAQSTSGIIGRDNSIPWRLPEDLARFKEMTMGHPVVMGRLTWESLPASVRPLPGRRNI 62 Query 64 VLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREA 123 V++R AD+ A GAEVV L + P+ WVIGG Q+YA+AL A RCEVTEVDI L Sbjct 63 VVTRDADYRAEGAEVVTDLPD---EPDAWVIGGAQIYAMALARADRCEVTEVDIALTPLD 119 Query 124 GDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 GDA APVLD++W TGEW+ S SGLR+R SY R Sbjct 120 GDARAPVLDDSWVATTGEWQTSTSGLRFRFCSYRR 154 >gi|169630172|ref|YP_001703821.1| dihydrofolate reductase DfrA [Mycobacterium abscessus ATCC 19977] gi|169242139|emb|CAM63167.1| Dihydrofolate reductase DfrA [Mycobacterium abscessus] Length=163 Score = 181 bits (458), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 92/159 (58%), Positives = 112/159 (71%), Gaps = 5/159 (3%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GLIWAQ +GVIG G IPWRLPEDQA F+ ITMGHT++MGR+TW+SLP VRPLPGR Sbjct 5 IGLIWAQTRAGVIGADGAIPWRLPEDQARFKRITMGHTVIMGRKTWESLPGSVRPLPGRP 64 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPET--WVIGGGQVYALALPYATRCEVTEVDIGL 119 N+VL+R A F GA VG + AL + + WVIGGG++Y L LP A RCEVT V+ + Sbjct 65 NIVLTRDALFEPDGALAVGCADAALAASDEAPWVIGGGEIYRLFLPLAQRCEVTVVEADV 124 Query 120 PREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 P GDALAP L E W E +W+ S SGLRY+ SY + Sbjct 125 P---GDALAPELGEGWVVEENDWQTSESGLRYQFLSYRK 160 >gi|302556751|ref|ZP_07309093.1| dihydrofolate reductase [Streptomyces griseoflavus Tu4000] gi|302474369|gb|EFL37462.1| dihydrofolate reductase [Streptomyces griseoflavus Tu4000] Length=168 Score = 168 bits (426), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 92/169 (55%), Positives = 110/169 (66%), Gaps = 15/169 (8%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGL+WAQ GVIG G IPWRLPED AHF+ +T+GH +VMGRRTWDSLP + RPLPGRR Sbjct 3 VGLVWAQTPDGVIGAGNAIPWRLPEDMAHFKAVTLGHPVVMGRRTWDSLPPRFRPLPGRR 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALT----SPE-------TWVIGGGQVYALALPYATRC 110 N+V++R + A GA GS+ EAL +PE WVIGGG++Y ALPYAT Sbjct 63 NIVVTRDPGWAAEGAVRAGSVAEALELASRTPEPAAPAGTAWVIGGGEIYRAALPYATTL 122 Query 111 EVTEVDIGLPREAGDALAPVLDETWR-GETGEWRFSRSGLRYRLYSYHR 158 VTEVD + +GD APV D W+ E R S SGLRYR+ Y R Sbjct 123 SVTEVDTPV---SGDTYAPVPDAEWKVAEDSGPRISTSGLRYRIRRYTR 168 >gi|332670063|ref|YP_004453071.1| dihydrofolate reductase region [Cellulomonas fimi ATCC 484] gi|332339101|gb|AEE45684.1| dihydrofolate reductase region [Cellulomonas fimi ATCC 484] Length=167 Score = 168 bits (425), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 95/165 (58%), Positives = 113/165 (69%), Gaps = 13/165 (7%) Query 4 LIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNV 63 L+WAQ +GVIG +PW +PEDQA FR +T GH +VMGR TW+SLP + RPLPGRRNV Sbjct 5 LVWAQTPAGVIGVDNTLPWHVPEDQARFRRLTTGHPVVMGRATWESLPERFRPLPGRRNV 64 Query 64 VLSRQADFMASGAEVVGSLEEALT---SPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 VLSR A + A GAEVVGSL+EAL ETWV+GGG VYALALP A R EVT VD +P Sbjct 65 VLSRDAAYDAPGAEVVGSLDEALALVGEAETWVVGGGAVYALALPLAERVEVTFVDRDVP 124 Query 121 REAGDALAPVLDET-WRGET-----GEWRFSRSGL-RYRLYSYHR 158 GD APVLD WR + G+W+ SR G+ RYR ++ R Sbjct 125 ---GDTYAPVLDAADWREQDPDDGPGDWQVSRDGVTRYRFRTWVR 166 >gi|226361377|ref|YP_002779155.1| dihydrofolate reductase [Rhodococcus opacus B4] gi|226239862|dbj|BAH50210.1| dihydrofolate reductase [Rhodococcus opacus B4] Length=163 Score = 167 bits (424), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 83/162 (52%), Positives = 114/162 (71%), Gaps = 7/162 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V L+WAQ + GVIGR IPW +PED A+F+++T GH ++MGRRTWDSLP + RPLPGRR Sbjct 5 VKLVWAQGSGGVIGRDNTIPWHVPEDMAYFKKVTQGHPVIMGRRTWDSLPPRFRPLPGRR 64 Query 62 NVVLSRQADFMASGAEVVGSLEE--ALTSPETWVIGGGQVYALALPYATRCEVTEVDIGL 119 N+V+SRQ D+ A GAE + ALT + VIGGGQ+Y A+P+AT+ V+E+D+ + Sbjct 65 NIVISRQPDWAAEGAESADGIASALALTDEDVCVIGGGQIYTAAMPFATQLLVSEIDVSI 124 Query 120 PREAGDALAPVLDETWRGE-TGEWRFS-RSGLRYRLYSYHRS 159 GDA AP +D++W + TGEW S ++G RYR +Y R+ Sbjct 125 ---DGDAWAPPIDDSWHAQDTGEWLTSEKNGTRYRWITYTRA 163 >gi|54026997|ref|YP_121239.1| putative dihydrofolate reductase [Nocardia farcinica IFM 10152] gi|54018505|dbj|BAD59875.1| putative dihydrofolate reductase [Nocardia farcinica IFM 10152] Length=171 Score = 166 bits (419), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 89/161 (56%), Positives = 110/161 (69%), Gaps = 7/161 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GLIWAQ T GVIG IPWR+PED A+FR +T GH ++MGRRTWDSLP K RPL GRR Sbjct 10 IGLIWAQTTDGVIGFENTIPWRVPEDMANFRTVTWGHPVIMGRRTWDSLPPKFRPLAGRR 69 Query 62 NVVLSRQADFMASGAEVVGSLEE--ALTSPET-WVIGGGQVYALALPYATRCEVTEVDIG 118 NVV++RQ D+ A GAE GSL E ALT PE+ W+ GG Q+Y A+ +AT VTEV + Sbjct 70 NVVVTRQPDWSAPGAERAGSLTEALALTEPESVWIAGGAQIYETAMDFATELLVTEVQVS 129 Query 119 LPREAGDALAPVLDETWR-GETGEWRFSRSGLRYRLYSYHR 158 + GDA APV+ WR E G R S +GL++R+ Y R Sbjct 130 V---QGDAHAPVIGAQWRLAEAGPERTSTTGLKFRINRYVR 167 >gi|296129375|ref|YP_003636625.1| Dihydrofolate reductase [Cellulomonas flavigena DSM 20109] gi|296021190|gb|ADG74426.1| Dihydrofolate reductase [Cellulomonas flavigena DSM 20109] Length=168 Score = 163 bits (413), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 91/163 (56%), Positives = 106/163 (66%), Gaps = 8/163 (4%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+GL+WAQ GVIG G IPW +PED AHFRE+T G T+VMGR TW+SLP + RPLPGR Sbjct 1 MIGLVWAQTPEGVIGDAGAIPWHVPEDMAHFREVTAGGTVVMGRATWESLPQRFRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPE-TWVIGGGQVYALALPYATRCEVTEVDIGL 119 RNVVLSR A + A GA V+ LE AL S E WVIGGG VYA L A R EVT VD+ + Sbjct 61 RNVVLSRDAAYDAPGATVLDDLETALHSAEDVWVIGGGAVYAATLDRADRLEVTVVDLDV 120 Query 120 PREAGDALAPVLDETWRGETG----EWRFSRSGLRYRLYSYHR 158 P GD AP + WR +G W SR+ RYR S+ R Sbjct 121 P---GDTRAPTIGPGWRRASGGPDTPWLVSRTATRYRFDSWVR 160 >gi|325676380|ref|ZP_08156059.1| dihydrofolate reductase [Rhodococcus equi ATCC 33707] gi|325552941|gb|EGD22624.1| dihydrofolate reductase [Rhodococcus equi ATCC 33707] Length=160 Score = 163 bits (412), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 84/162 (52%), Positives = 107/162 (67%), Gaps = 7/162 (4%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+GLIWAQ TSGVIGR IPWR+PED A F++ TMGH +VMGR TW+SLP K RPL GR Sbjct 1 MIGLIWAQTTSGVIGRDNTIPWRVPEDMARFKDTTMGHPVVMGRLTWESLPPKFRPLAGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEAL--TSPETWVIGGGQVYALALPYATRCEVTEVDIG 118 N+V++RQ + A GA +E+AL WV+GG Q+YA A+P+A VTE+D Sbjct 61 TNIVVTRQDGWSADGARTAHGIEQALEVAGDTAWVMGGSQIYAAAMPFADLLSVTEIDAD 120 Query 119 LPREAGDALAPVLDETWR-GETGEWRFS-RSGLRYRLYSYHR 158 + GDA AP + W G+ G+W S +SGLRYR +Y R Sbjct 121 I---EGDAFAPTIGNEWVIGDEGDWHISEKSGLRYRFLTYVR 159 >gi|111019242|ref|YP_702214.1| dihydrofolate reductase [Rhodococcus jostii RHA1] gi|110818772|gb|ABG94056.1| dihydrofolate reductase [Rhodococcus jostii RHA1] Length=168 Score = 162 bits (410), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 82/162 (51%), Positives = 111/162 (69%), Gaps = 7/162 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V L+WAQ GVIG IPW +PED A+F+++T GH ++MGRRTWDSLP + RPLPGRR Sbjct 6 VKLVWAQGVGGVIGLDNTIPWHVPEDMAYFKQVTQGHPVIMGRRTWDSLPPRFRPLPGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEE--ALTSPETWVIGGGQVYALALPYATRCEVTEVDIGL 119 N+V+SRQ D+ A GAE L ALT + VIGG Q+Y A+P+AT+ V+E+D+ + Sbjct 66 NIVISRQPDWTAEGAESADGLGSALALTDEDVCVIGGAQIYTAAMPFATQLLVSEIDVTI 125 Query 120 PREAGDALAPVLDETWRGE-TGEWRFS-RSGLRYRLYSYHRS 159 GDA AP +D++W + TGEW S ++G RYR +Y R+ Sbjct 126 ---DGDAWAPPIDDSWHAQDTGEWLTSAKNGTRYRWITYTRA 164 >gi|229495093|ref|ZP_04388839.1| dihydrofolate reductase [Rhodococcus erythropolis SK121] gi|229318024|gb|EEN83899.1| dihydrofolate reductase [Rhodococcus erythropolis SK121] Length=163 Score = 162 bits (410), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 84/161 (53%), Positives = 113/161 (71%), Gaps = 7/161 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V LIWAQA GVIG IPWR+ ED A+F+ +TMGH ++MGRRTWDS+P+K RP GRR Sbjct 6 VTLIWAQAHGGVIGADNSIPWRVSEDMAYFKRVTMGHPVIMGRRTWDSIPSKFRPFSGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSP--ETWVIGGGQVYALALPYATRCEVTEVDIGL 119 N+V++R + A GAEVV SL++AL P + +V+GGGQ+Y+ ALP+AT VTE+D+ + Sbjct 66 NIVVTRDPQWHAEGAEVVRSLDDALALPDGDVFVVGGGQIYSAALPFATHLLVTEIDLDI 125 Query 120 PREAGDALAPVLDETWRGETGE-WRFS-RSGLRYRLYSYHR 158 AGDA AP + W ++ E W+ S +SGLR+R Y R Sbjct 126 ---AGDAFAPEIGPEWNLKSDEPWQTSEKSGLRFRWLEYTR 163 >gi|229821346|ref|YP_002882872.1| Dihydrofolate reductase [Beutenbergia cavernae DSM 12333] gi|229567259|gb|ACQ81110.1| Dihydrofolate reductase [Beutenbergia cavernae DSM 12333] Length=169 Score = 162 bits (410), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 83/169 (50%), Positives = 113/169 (67%), Gaps = 10/169 (5%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+G+IWAQA GVIG G +PW +PED AHF+ T GH +VMGR TWDSLP + RP+P R Sbjct 1 MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEAL----TSPETWVIGGGQVYALALPYATRCEVTEVD 116 RNVV++RQ D+ A GAE GS+ +AL PETW++GG Q+YA A+PYA VT++D Sbjct 61 RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120 Query 117 IGLPREAGDAL--APVLDETWRGET----GEWRFSRSGLRYRLYSYHRS 159 + L E + AP + WR T G W+ SR+G+R++++ Y R+ Sbjct 121 LALDVEGAPDVVHAPPIGPEWRIATDTWDGTWQTSRTGVRWQVHQYVRA 169 >gi|50954681|ref|YP_061969.1| dihydrofolate reductase [Leifsonia xyli subsp. xyli str. CTCB07] gi|50951163|gb|AAT88864.1| dihydrofolate reductase [Leifsonia xyli subsp. xyli str. CTCB07] Length=159 Score = 162 bits (410), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 84/160 (53%), Positives = 107/160 (67%), Gaps = 6/160 (3%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 + LIWAQA + VIG GG +PWRLPED HFRE+T G +VMGRRTW+SLP + RPLPGRR Sbjct 3 IALIWAQARNRVIGAGGTMPWRLPEDLRHFRELTGGEPVVMGRRTWESLPDRFRPLPGRR 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPE---TWVIGGGQVYALALPYATRCEVTEVDIG 118 N+V++RQ + A GAEV +L AL++ WVIGGG++Y ALP A R EVTE+D+ Sbjct 63 NIVVTRQEGWNAPGAEVAHALPGALSAASDDTVWVIGGGELYRQALPLADRVEVTEIDLA 122 Query 119 LPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 + AGD AP L W + W + +G+RYR Y R Sbjct 123 V---AGDTPAPALGPEWHAQPTPWLTAENGMRYRFLRYLR 159 >gi|226307949|ref|YP_002767909.1| dihydrofolate reductase [Rhodococcus erythropolis PR4] gi|226187066|dbj|BAH35170.1| dihydrofolate reductase [Rhodococcus erythropolis PR4] Length=163 Score = 161 bits (407), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 84/161 (53%), Positives = 111/161 (69%), Gaps = 7/161 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V LIWAQA GVIG IPWR+ ED A+F+ +TMGH ++MGRRTWDS+P K RP GRR Sbjct 6 VTLIWAQAHDGVIGVDNTIPWRVSEDMAYFKRVTMGHPVIMGRRTWDSIPLKFRPFSGRR 65 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSP--ETWVIGGGQVYALALPYATRCEVTEVDIGL 119 N+V++R + A GAEVV L++AL P + +V+GGGQ+Y+ ALP+AT VTEVD+ + Sbjct 66 NIVITRDPQWQAEGAEVVHRLDDALALPDGDVFVVGGGQIYSAALPFATHLLVTEVDLDI 125 Query 120 PREAGDALAPVLDETWRGETGE-WRFS-RSGLRYRLYSYHR 158 AGDA AP + W ++ E W+ S +SGLR+R Y R Sbjct 126 ---AGDAFAPEIGPEWNLKSDEPWQTSEKSGLRFRWLEYTR 163 >gi|312138556|ref|YP_004005892.1| dihydrofolate reductase [Rhodococcus equi 103S] gi|311887895|emb|CBH47207.1| putative dihydrofolate reductase [Rhodococcus equi 103S] Length=160 Score = 161 bits (407), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 83/162 (52%), Positives = 105/162 (65%), Gaps = 7/162 (4%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+GLIWAQ TSGVIGR IPWR+PED A F++ TMGH +VMGR TW+SLP K RPL GR Sbjct 1 MIGLIWAQTTSGVIGRDNTIPWRVPEDMARFKDTTMGHPVVMGRLTWESLPPKFRPLAGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEAL--TSPETWVIGGGQVYALALPYATRCEVTEVDIG 118 N+V++RQ + A GA +E+AL WV+GG Q+Y A+P+A VTE+D Sbjct 61 TNIVVTRQDGWSADGARTAHGIEQALEVAGDTAWVMGGSQIYTAAMPFADLLSVTEIDAD 120 Query 119 LPREAGDALAPVLDETWR-GETGEWRFS-RSGLRYRLYSYHR 158 + GDA AP + W G G+W S +SGLRYR +Y R Sbjct 121 I---EGDAFAPTIGNEWVIGNEGDWHISEKSGLRYRFLTYVR 159 >gi|271966277|ref|YP_003340473.1| dihydrofolate reductase [Streptosporangium roseum DSM 43021] gi|270509452|gb|ACZ87730.1| Dihydrofolate reductase [Streptosporangium roseum DSM 43021] Length=167 Score = 160 bits (406), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 86/168 (52%), Positives = 106/168 (64%), Gaps = 14/168 (8%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VGLIWAQ +GVIG IPWRLPED AHF+ T+GH +VMGR+TWDSLP + RPL RR Sbjct 3 VGLIWAQTLNGVIGADNGIPWRLPEDMAHFKATTLGHPVVMGRKTWDSLPPRFRPLSDRR 62 Query 62 NVVLSRQADFMASGAEVVGSLEEAL----------TSPETWVIGGGQVYALALPYATRCE 111 N+V++R ++ GAE GS+ +AL WVIGGG++Y AL YAT Sbjct 63 NIVVTRDPHWVVEGAERAGSIAQALELAAEPSETAAPAAVWVIGGGEIYRAALGYATMLS 122 Query 112 VTEVDIGLPREAGDALAPVLDETWR-GETGEWRFSRSGLRYRLYSYHR 158 VTEVD+ + GD AP LD TW+ E W+ S SGLRYR+ Y R Sbjct 123 VTEVDLTV---NGDTYAPTLDSTWKVAEDRGWQSSTSGLRYRIRRYTR 167 >gi|296139475|ref|YP_003646718.1| dihydrofolate reductase [Tsukamurella paurometabola DSM 20162] gi|296027609|gb|ADG78379.1| Dihydrofolate reductase [Tsukamurella paurometabola DSM 20162] Length=158 Score = 160 bits (406), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 88/160 (55%), Positives = 106/160 (67%), Gaps = 6/160 (3%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+GLIWAQA SGVIG GG IPW +PED FRE T G T+VMGR+TWDSLPA+ RPLPGR Sbjct 1 MIGLIWAQARSGVIGDGGGIPWHIPEDMKFFRETTAGATVVMGRKTWDSLPARFRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLP 120 N+V++R D+ A GA V E L + WVIGGG++YA ALP A VTEVD +P Sbjct 61 TNIVVTRDRDWSADGAVV--HHELVLPEGDVWVIGGGEIYAAALPSADLLAVTEVDADIP 118 Query 121 REAGDALAPVLDETWRG-ETGEWRFSRSGLRYRLYSYHRS 159 GD AP + + + E WR S SGLRYR +Y R+ Sbjct 119 ---GDTYAPSIPDGFTATEDTGWRESTSGLRYRHLTYRRT 155 >gi|334338010|ref|YP_004543162.1| dihydrofolate reductase [Isoptericola variabilis 225] gi|334108378|gb|AEG45268.1| Dihydrofolate reductase [Isoptericola variabilis 225] Length=177 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 94/174 (55%), Positives = 109/174 (63%), Gaps = 18/174 (10%) Query 1 MVGLIWAQATSG----VIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRP 56 M+GLIWAQA VIG GG IPWR+PED AHFR T GH +VMGR TW+SLP + RP Sbjct 1 MIGLIWAQAHDDAGRPVIGAGGQIPWRIPEDFAHFRRTTTGHPVVMGRLTWESLPPRFRP 60 Query 57 LPGRRNVVLSRQADFMASGAEVVGSLEE--------ALTSPETWVIGGGQVYALALPYAT 108 LPGR NVV++RQAD+ A GA V SLEE + E WVIGG QVYA ALP A Sbjct 61 LPGRTNVVVTRQADWTAEGAVVAPSLEEGLAAAGYAPGGAQEVWVIGGAQVYAQALPLAD 120 Query 109 RCEVTEVDIGLPREAGDALAPVLDETWR-GETGEWRFSR--SGLRYRLYSYHRS 159 C VTEVD+ + GDA APVL W + G W S LRYR+ +Y R+ Sbjct 121 TCVVTEVDLEV---EGDAFAPVLGLDWTPADDGAWATSSGPGALRYRIRTYTRA 171 >gi|317508367|ref|ZP_07966040.1| dihydrofolate reductase [Segniliparus rugosus ATCC BAA-974] gi|316253324|gb|EFV12721.1| dihydrofolate reductase [Segniliparus rugosus ATCC BAA-974] Length=162 Score = 157 bits (396), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 85/164 (52%), Positives = 110/164 (68%), Gaps = 10/164 (6%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VG++WAQ +GVIG G++PW +PED FR++T+GHT+VMGRRTWDSLP + RPLP R Sbjct 3 VGVVWAQGRNGVIGIDGELPWSIPEDMRRFRQLTVGHTVVMGRRTWDSLPEQFRPLPKRT 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSP-----ETWVIGGGQVYALALPYATRCEVTEVD 116 NVVLSR F A GA+V + A T+P WVIGGG+VYA A+ A+ E+TEVD Sbjct 63 NVVLSRDRAFSAEGAQVEHDIVSA-TAPGRAGETVWVIGGGEVYAKAVHLASVAEITEVD 121 Query 117 IGLPREAGDALAPVLDETWR-GETGEWRFSRSGLRYRLYSYHRS 159 + GDA AP L WR + G W++S SGLRYR ++ R+ Sbjct 122 FEV---EGDAYAPQLAVGWRVVKEGPWQYSESGLRYRFTTFQRA 162 >gi|222110328|ref|YP_002552592.1| dihydrofolate reductase [Acidovorax ebreus TPSY] gi|221729772|gb|ACM32592.1| Dihydrofolate reductase [Acidovorax ebreus TPSY] Length=164 Score = 154 bits (390), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 81/163 (50%), Positives = 101/163 (62%), Gaps = 9/163 (5%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V LI+A+A +GVIG+ G +PW LPED AHF+ +T GH ++MGR+TWDSLP + RPLPGR Sbjct 3 VNLIYARAANGVIGKNGTMPWHLPEDLAHFKALTQGHPVIMGRKTWDSLPPRFRPLPGRA 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALT------SPETWVIGGGQVYALALPYATRCEVTEV 115 N+V++RQAD+ SGA+ SL EAL S WVIGG Q+YA ALP ATR EVTE+ Sbjct 63 NIVVTRQADWQESGAQRASSLPEALALAQQSGSTTAWVIGGAQIYAQALPLATRVEVTEI 122 Query 116 DIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 GDA AP L W GL Y ++ R Sbjct 123 AQDY---EGDAYAPALGPEWVETARSNHVGAGGLPYAFVTFER 162 >gi|330824058|ref|YP_004387361.1| dihydrofolate reductase [Alicycliphilus denitrificans K601] gi|329309430|gb|AEB83845.1| Dihydrofolate reductase [Alicycliphilus denitrificans K601] Length=164 Score = 154 bits (389), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 81/162 (50%), Positives = 103/162 (64%), Gaps = 8/162 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V LI+A+A +GVIG+ G +PW LPED AHF+ +T GH ++MGR+TWDSLPA+ RPLPGR Sbjct 3 VHLIYARAANGVIGKDGAMPWHLPEDLAHFKRLTQGHPVIMGRKTWDSLPARFRPLPGRA 62 Query 62 NVVLSRQADFMASGAEVVGSLEEAL-----TSPETWVIGGGQVYALALPYATRCEVTEVD 116 N+V++RQAD+ GA+ SL EAL T E W+IGG Q+YA ALP ATR EVTE+ Sbjct 63 NIVVTRQADWNEIGAQRASSLREALSVAEQTGSEAWIIGGAQIYAQALPLATRIEVTEIG 122 Query 117 IGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 GDA AP L W+ GL + +Y R Sbjct 123 RDF---DGDAHAPQLGPEWQEVARSRHVGSGGLPFSFVTYER 161 >gi|319763677|ref|YP_004127614.1| dihydrofolate reductase [Alicycliphilus denitrificans BC] gi|317118238|gb|ADV00727.1| Dihydrofolate reductase [Alicycliphilus denitrificans BC] Length=165 Score = 154 bits (389), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 81/162 (50%), Positives = 103/162 (64%), Gaps = 8/162 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 V LI+A+A +GVIG+ G +PW LPED AHF+ +T GH ++MGR+TWDSLPA+ RPLPGR Sbjct 4 VHLIYARAANGVIGKDGAMPWHLPEDLAHFKRLTQGHPVIMGRKTWDSLPARFRPLPGRA 63 Query 62 NVVLSRQADFMASGAEVVGSLEEAL-----TSPETWVIGGGQVYALALPYATRCEVTEVD 116 N+V++RQAD+ GA+ SL EAL T E W+IGG Q+YA ALP ATR EVTE+ Sbjct 64 NIVVTRQADWNEIGAQRASSLREALSVAEQTGSEAWIIGGAQIYAQALPLATRIEVTEIG 123 Query 117 IGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 GDA AP L W+ GL + +Y R Sbjct 124 RDF---DGDAHAPQLGPEWQEVARSRHVGSGGLPFSFVTYER 162 >gi|152968377|ref|YP_001364161.1| dihydrofolate reductase [Kineococcus radiotolerans SRS30216] gi|151362894|gb|ABS05897.1| Dihydrofolate reductase [Kineococcus radiotolerans SRS30216] Length=171 Score = 154 bits (388), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 86/161 (54%), Positives = 108/161 (68%), Gaps = 5/161 (3%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+GL+WAQ+ +GVIG GG IPWR+PED AHF +T G T+VMGR TW+SLPA+ RPLPGR Sbjct 1 MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALT-SPETWVIGGGQVYALALPYATRCEVTEVDIGL 119 RN+VLSR + A GAEVV L AL + + WVIGG VY AL +A VTEVD+ + Sbjct 61 RNLVLSRDPGYAAEGAEVVHDLPGALAGAGDVWVIGGSAVYRAALEHADVLVVTEVDLVV 120 Query 120 PREAGDALAPVLDETW-RGETGEWRFSRSGLRYRLYSYHRS 159 GD AP + W R E G+W S G R+R+ ++ RS Sbjct 121 ---EGDTRAPEVGPGWERVEVGDWATSTGGPRFRIGTWRRS 158 >gi|326384523|ref|ZP_08206203.1| dihydrofolate reductase region [Gordonia neofelifaecis NRRL B-59395] gi|326196868|gb|EGD54062.1| dihydrofolate reductase region [Gordonia neofelifaecis NRRL B-59395] Length=164 Score = 153 bits (387), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 80/161 (50%), Positives = 108/161 (68%), Gaps = 6/161 (3%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 + L+WAQ +G IGRGG IPWR+PED F+E+T G T++MGR+TW+SLPA VRPLPGRR Sbjct 3 ITLVWAQDRAGAIGRGGTIPWRVPEDMRRFKELTGGGTVIMGRKTWESLPASVRPLPGRR 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSP--ETWVIGGGQVYALALPYATRCEVTEVDIGL 119 N+V++R + A GA+VV L+ AL + VIGGG++YA + AT VTE+D+ + Sbjct 63 NIVVTRAVGYRAEGADVVNGLDAALDAAGHVAAVIGGGEIYAAVMDRATSLRVTEIDVLV 122 Query 120 PREAGDALAPVLD-ETWR-GETGEWRFSRSGLRYRLYSYHR 158 + DA AP +D + W ETGEW +S +G YR Y R Sbjct 123 --DGADAFAPAVDPDRWESAETGEWLYSSTGTLYRFVDYVR 161 >gi|336287822|gb|AEI30195.1| dihydrofolate reductase [uncultured bacterium] Length=164 Score = 153 bits (387), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 90/166 (55%), Positives = 108/166 (66%), Gaps = 13/166 (7%) Query 1 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGR 60 M+GL+WAQA +GVIGR G +PW+LPED A F+ +T G T+VMGR TWDSLPA VRPLPGR Sbjct 1 MIGLVWAQAANGVIGRDGTLPWQLPEDLARFKALTTGATVVMGRATWDSLPASVRPLPGR 60 Query 61 RNVVLSRQADFMASGAEVVGSLEEALTSP-ETWVIGGGQVYALALPYATRCEVTEVDIGL 119 RNVVL+RQ + A GA V GSL E L + WVIGG VY ALPYA VTE+D + Sbjct 61 RNVVLTRQDGWRADGAVVAGSLAEGLDQDGDVWVIGGATVYRAALPYADVLVVTELDRAV 120 Query 120 PREAGDALAPVLDETWRGETGE------WRFSRSGLRYRLYSY-HR 158 GD +AP + W E E SRSGL YR+ ++ HR Sbjct 121 ---EGDTVAPAIGPEW--EVAEVDPPTGLHPSRSGLGYRVVTWRHR 161 >gi|319792494|ref|YP_004154134.1| dihydrofolate reductase region [Variovorax paradoxus EPS] gi|315594957|gb|ADU36023.1| dihydrofolate reductase region [Variovorax paradoxus EPS] Length=173 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 84/165 (51%), Positives = 107/165 (65%), Gaps = 11/165 (6%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 + LI+A+A +GVIG G IPW LPED AHF++ T G ++MGR+TWDSLP + RPLPGR+ Sbjct 6 INLIYARAANGVIGVNGTIPWHLPEDMAHFKQKTAGAPVIMGRKTWDSLPPRFRPLPGRQ 65 Query 62 NVVLSRQADFMASGAEVVGSLEEALT------SPETWVIGGGQVYALALPYATRCEVTEV 115 N+V++RQAD+ A GA VG+L +AL+ SPE WVIGG Q+YA A P A R VTE+ Sbjct 66 NIVVTRQADWRAEGALPVGNLRDALSLCAEAASPEVWVIGGAQIYAEAEPLAQRAVVTEI 125 Query 116 DIGLPREAGDALAPVLD-ETWRGETGEWRFS-RSGLRYRLYSYHR 158 GDA APVLD WR E S + GL + +Y R Sbjct 126 ARDY---EGDAHAPVLDGAAWRETQRESHVSAKDGLGFSFVTYER 167 >gi|337279087|ref|YP_004618558.1| dihydrofolate reductase [Ramlibacter tataouinensis TTB310] gi|334730163|gb|AEG92539.1| candidate dihydrofolate reductase [Ramlibacter tataouinensis TTB310] Length=163 Score = 151 bits (382), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 80/162 (50%), Positives = 106/162 (66%), Gaps = 7/162 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 +GLI+A+A +GVIGR G +PW LPED AHF+++T+G ++MGR+TWDSLP + RPLPGRR Sbjct 3 LGLIFARAANGVIGRHGGLPWHLPEDLAHFKQVTLGCPVIMGRKTWDSLPPRFRPLPGRR 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSPE----TWVIGGGQVYALALPYATRCEVTEVDI 117 N+V++RQ + A GA+ GSL EAL E WVIGG ++Y LALP+A E TE+ Sbjct 63 NIVVTRQPGWQAEGAQRAGSLREALALCEGQRQAWVIGGAELYRLALPHAQVVEATEIGA 122 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 159 GDA AP L W E S +GL + +YHR+ Sbjct 123 ---EYDGDAYAPDLGPAWLEVARERHQSPAGLPFDFVTYHRA 161 >gi|91787701|ref|YP_548653.1| dihydrofolate reductase [Polaromonas sp. JS666] gi|91696926|gb|ABE43755.1| dihydrofolate reductase [Polaromonas sp. JS666] Length=164 Score = 151 bits (381), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 76/161 (48%), Positives = 100/161 (63%), Gaps = 7/161 (4%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 + +I+A+A +GVIG +PW LPED AHF+ +T G ++MGR+TWDSLP K RPLPGR Sbjct 3 INMIFARAANGVIGNNNRMPWHLPEDMAHFKRLTQGWPVIMGRKTWDSLPPKFRPLPGRT 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALT----SPETWVIGGGQVYALALPYATRCEVTEVDI 117 N+V++RQ D+ GAE SL +AL+ S E WVIGG Q+YA A P A R EVTE+ Sbjct 63 NIVITRQQDWKEDGAEPAASLADALSLCGQSEEVWVIGGAQIYAQAKPLAQRIEVTEIAQ 122 Query 118 GLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHR 158 GDA AP L W E S +GL++ +Y + Sbjct 123 DF---EGDAFAPPLGSEWIEAAREDHISSNGLKFSFITYDK 160 >gi|296394395|ref|YP_003659279.1| dihydrofolate reductase region [Segniliparus rotundus DSM 44985] gi|296181542|gb|ADG98448.1| dihydrofolate reductase region [Segniliparus rotundus DSM 44985] Length=162 Score = 151 bits (381), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 83/164 (51%), Positives = 107/164 (66%), Gaps = 10/164 (6%) Query 2 VGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRR 61 VG++WAQ +GVIG G++PW +PED FR++T+GHT+VMGR+TWDSLPA+ RPLP R Sbjct 3 VGVLWAQGRNGVIGIDGELPWSIPEDMRRFRQLTVGHTVVMGRKTWDSLPARFRPLPERT 62 Query 62 NVVLSRQADFMASGAEVVGSLEEALTSP-----ETWVIGGGQVYALALPYATRCEVTEVD 116 NVVLSR + A GA+V + A T+P WVIGGG+VYA A+ A E+TEVD Sbjct 63 NVVLSRDRGYTAQGAQVAHDVVTA-TAPGRAGETVWVIGGGEVYAKAVHLAAIAEITEVD 121 Query 117 IGLPREAGDALAPVLDETWR-GETGEWRFSRSGLRYRLYSYHRS 159 + GD AP L WR G W+ S SGLRYR ++ R+ Sbjct 122 FEV---EGDVYAPQLGVGWRVAAEGPWQRSESGLRYRFTTFRRA 162 Lambda K H 0.320 0.137 0.435 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 128329112580 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40