BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2847c Length=405 Score E Sequences producing significant alignments: (Bits) Value gi|15842388|ref|NP_337425.1| uroporphyrinogen III methyltransfer... 788 0.0 gi|339632856|ref|YP_004724498.1| multifunctional enzyme siroheme... 786 0.0 gi|289758967|ref|ZP_06518345.1| uroporphyrinogen III methyltrans... 694 0.0 gi|308232263|ref|ZP_07415468.2| multifunctional siroheme synthas... 690 0.0 gi|339295688|gb|AEJ47799.1| multifunctional siroheme synthase cy... 674 0.0 gi|240172752|ref|ZP_04751411.1| uroporphyrin-III C-methyltransfe... 661 0.0 gi|41409014|ref|NP_961850.1| CysG2 [Mycobacterium avium subsp. p... 650 0.0 gi|254776133|ref|ZP_05217649.1| uroporphyrin-III C-methyltransfe... 649 0.0 gi|254819682|ref|ZP_05224683.1| uroporphyrin-III C-methyltransfe... 648 0.0 gi|342858321|ref|ZP_08714976.1| uroporphyrin-III C-methyltransfe... 647 0.0 gi|183981899|ref|YP_001850190.1| multifunctional enzyme siroheme... 647 0.0 gi|296171594|ref|ZP_06852834.1| uroporphyrinogen-III C-methyltra... 646 0.0 gi|118617674|ref|YP_906006.1| multifunctional enzyme siroheme sy... 643 0.0 gi|108799041|ref|YP_639238.1| uroporphyrinogen-III C-methyltrans... 640 0.0 gi|145224627|ref|YP_001135305.1| uroporphyrin-III C-methyltransf... 623 2e-176 gi|333991211|ref|YP_004523825.1| multifunctional enzyme siroheme... 617 1e-174 gi|120403296|ref|YP_953125.1| uroporphyrin-III C-methyltransfera... 613 1e-173 gi|118472829|ref|YP_886955.1| uroporphyrin-III C-methyltransfera... 608 6e-172 gi|289571035|ref|ZP_06451262.1| multifunctional siroheme synthas... 583 1e-164 gi|169630225|ref|YP_001703874.1| multifunctional siroheme syntha... 579 2e-163 gi|229491428|ref|ZP_04385252.1| uroporphyrin-III C-methyltransfe... 534 1e-149 gi|312139292|ref|YP_004006628.1| uroporphyrinogen-III C-methyltr... 533 2e-149 gi|226306097|ref|YP_002766057.1| siroheme synthase CysG [Rhodoco... 533 3e-149 gi|333919282|ref|YP_004492863.1| Siroheme synthase CysG [Amycoli... 530 2e-148 gi|325673402|ref|ZP_08153093.1| uroporphyrinogen-III C-methyltra... 529 4e-148 gi|111023576|ref|YP_706548.1| uroporphyrin-III C-methyltransfera... 520 2e-145 gi|226366062|ref|YP_002783845.1| siroheme synthase CysG [Rhodoco... 517 1e-144 gi|324999818|ref|ZP_08120930.1| uroporphyrinogen-iii c-methyltra... 487 1e-135 gi|54026048|ref|YP_120290.1| putative uroporphyrinogen III methy... 483 3e-134 gi|296139417|ref|YP_003646660.1| uroporphyrin-III C-methyltransf... 480 2e-133 gi|331696542|ref|YP_004332781.1| uroporphyrin-III C-methyltransf... 477 2e-132 gi|298526315|ref|ZP_07013724.1| conserved hypothetical protein [... 474 1e-131 gi|329939003|ref|ZP_08288377.1| uroporphyrin-III methyltransfera... 463 3e-128 gi|300786876|ref|YP_003767167.1| uroporphyrin-III C-methyltransf... 461 9e-128 gi|297155856|gb|ADI05568.1| uroporphyrin-III methyltransferase [... 452 6e-125 gi|302527613|ref|ZP_07279955.1| uroporphyrin-III C-methyltransfe... 447 2e-123 gi|302550201|ref|ZP_07302543.1| uroporphyrin-III methyltransfera... 446 4e-123 gi|262202077|ref|YP_003273285.1| uroporphyrin-III C-methyltransf... 444 1e-122 gi|302541205|ref|ZP_07293547.1| uroporphyrinogen-III C-methyltra... 443 2e-122 gi|29833338|ref|NP_827972.1| uroporphyrin-III methyltransferase ... 442 4e-122 gi|302533438|ref|ZP_07285780.1| uroporphyrin-III methyltransfera... 441 9e-122 gi|345010602|ref|YP_004812956.1| uroporphyrin-III C-methyltransf... 441 1e-121 gi|343926760|ref|ZP_08766257.1| siroheme synthase CysG [Gordonia... 438 6e-121 gi|289751509|ref|ZP_06510887.1| multifunctional siroheme synthas... 437 1e-120 gi|294811613|ref|ZP_06770256.1| Putative uroporphyrin-III methyl... 437 2e-120 gi|302561651|ref|ZP_07313993.1| uroporphyrinogen-III C-methyltra... 436 3e-120 gi|291440727|ref|ZP_06580117.1| uroporphyrin-III methyltransfera... 436 4e-120 gi|326382930|ref|ZP_08204620.1| uroporphyrin-III C-methyltransfe... 436 4e-120 gi|337769247|emb|CCB77960.1| putative uroporphyrin-III methyltra... 434 1e-119 gi|328881200|emb|CCA54439.1| Siroheme synthase or Precorrin-2 ox... 431 1e-118 >gi|15842388|ref|NP_337425.1| uroporphyrinogen III methyltransferase [Mycobacterium tuberculosis CDC1551] gi|31794024|ref|NP_856517.1| multifunctional uroporphyrinogen III methylase/precorrin-2 oxidase/ferrochelatase [Mycobacterium bovis AF2122/97] gi|57117027|ref|NP_215025.2| multifunctional uroporphyrinogen III methylase/precorrin-2 oxidase/ferrochelatase [Mycobacterium tuberculosis H37Rv] 53 more sequence titles Length=405 Score = 788 bits (2034), Expect = 0.0, Method: Compositional matrix adjust. Identities = 404/405 (99%), Positives = 405/405 (100%), Gaps = 0/405 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS Sbjct 1 MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG Sbjct 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV Sbjct 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV Sbjct 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT Sbjct 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 Query 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS Sbjct 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 >gi|339632856|ref|YP_004724498.1| multifunctional enzyme siroheme synthase CYSG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase [Mycobacterium africanum GM041182] gi|339332212|emb|CCC27922.1| putative multifunctional enzyme siroheme synthase CYSG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase [Mycobacterium africanum GM041182] Length=405 Score = 786 bits (2031), Expect = 0.0, Method: Compositional matrix adjust. Identities = 403/405 (99%), Positives = 405/405 (100%), Gaps = 0/405 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS Sbjct 1 MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG Sbjct 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV Sbjct 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDPFVFARGYEE+LACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV Sbjct 241 VRLKGGDPFVFARGYEEMLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT Sbjct 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 Query 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS Sbjct 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 >gi|289758967|ref|ZP_06518345.1| uroporphyrinogen III methyltransferase [Mycobacterium tuberculosis T85] gi|289714531|gb|EFD78543.1| uroporphyrinogen III methyltransferase [Mycobacterium tuberculosis T85] Length=388 Score = 694 bits (1792), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/357 (99%), Positives = 357/357 (100%), Gaps = 0/357 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS Sbjct 1 MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG Sbjct 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV Sbjct 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV Sbjct 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH Sbjct 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 >gi|308232263|ref|ZP_07415468.2| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis SUMu001] gi|308371155|ref|ZP_07423997.2| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis SUMu003] gi|308372273|ref|ZP_07428037.2| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis SUMu004] 11 more sequence titles Length=352 Score = 690 bits (1780), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/352 (100%), Positives = 352/352 (100%), Gaps = 0/352 (0%) Query 54 MDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTP 113 MDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTP Sbjct 1 MDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTP 60 Query 114 ASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPE 173 ASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPE Sbjct 61 ASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPE 120 Query 174 LITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIER 233 LITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIER Sbjct 121 LITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIER 180 Query 234 ARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAM 293 ARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAM Sbjct 181 ARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAM 240 Query 294 THEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVL 353 THEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVL Sbjct 241 THEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVL 300 Query 354 VVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 VVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS Sbjct 301 VVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 352 >gi|339295688|gb|AEJ47799.1| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis CCDC5079] gi|339299303|gb|AEJ51413.1| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis CCDC5180] Length=345 Score = 674 bits (1738), Expect = 0.0, Method: Compositional matrix adjust. Identities = 344/345 (99%), Positives = 345/345 (100%), Gaps = 0/345 (0%) Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +RDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG Sbjct 1 MRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 60 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR Sbjct 61 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 120 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV Sbjct 121 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 180 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV Sbjct 181 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 240 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT Sbjct 241 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 300 Query 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS Sbjct 301 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 345 >gi|240172752|ref|ZP_04751411.1| uroporphyrin-III C-methyltransferase [Mycobacterium kansasii ATCC 12478] Length=411 Score = 661 bits (1705), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/411 (86%), Positives = 377/411 (92%), Gaps = 6/411 (1%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+PYLVGLR+AGKKVVVVGGG+VAQRRLPLLI+SGADVHVI S T AVEAM+ ITLS Sbjct 1 MTESPYLVGLRMAGKKVVVVGGGSVAQRRLPLLISSGADVHVITRSATRAVEAMEGITLS 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDL+GAWYAIAATDDA VN VVAEA+ R+IFCVRAD+AVEG+AVTPA+FSYAG Sbjct 61 LREYRDGDLEGAWYAIAATDDAEVNATVVAEADSRQIFCVRADVAVEGSAVTPATFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQS------SDVLSGGVALVGGGPGDPEL 174 LSVGVLAGGEHRRSAAIRSAIREALQ G+IT +S SDV+ GGVALVGGGPGDPEL Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQTGLITPESPEGPVSSDVVHGGVALVGGGPGDPEL 180 Query 175 ITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERA 234 ITVRGRRLLA ADVV+ADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAI+A +IERA Sbjct 181 ITVRGRRLLAHADVVIADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIHAAMIERA 240 Query 235 RSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMT 294 +SG+FVVRLKGGDPFVFARGYEEVLACA AGIPVTVVPGVTSAIAVPA AGVPVTHRA Sbjct 241 KSGSFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIAVPASAGVPVTHRATN 300 Query 295 HEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLV 354 HEFVVVSGHL PGHPESLVNW+ALAAL+GTIVLLMAVERIELFVD LLKGGR A TPVLV Sbjct 301 HEFVVVSGHLPPGHPESLVNWNALAALSGTIVLLMAVERIELFVDALLKGGRPAKTPVLV 360 Query 355 VQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 VQ GTT AQ TLRATLADTPEKVRA GIRPPAI+VIGAV GL GVRGLN+S Sbjct 361 VQQGTTPAQHTLRATLADTPEKVRAEGIRPPAIVVIGAVAGLGGVRGLNDS 411 >gi|41409014|ref|NP_961850.1| CysG2 [Mycobacterium avium subsp. paratuberculosis K-10] gi|118462961|ref|YP_882880.1| uroporphyrin-III C-methyltransferase [Mycobacterium avium 104] gi|41397373|gb|AAS05233.1| CysG2 [Mycobacterium avium subsp. paratuberculosis K-10] gi|118164248|gb|ABK65145.1| uroporphyrin-III C-methyltransferase [Mycobacterium avium 104] gi|336458988|gb|EGO37940.1| uroporphyrin-III C-methyltransferase [Mycobacterium avium subsp. paratuberculosis S397] Length=401 Score = 650 bits (1677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/396 (89%), Positives = 367/396 (93%), Gaps = 3/396 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+ YLVGLRL GKKVVVVGGGTVAQRRLPLLIASGADVHVI+ S T +VEAM ITL Sbjct 1 MTESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQ 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDLDGAWYAIAATDD RVN AVVAEAERRRIFCVRAD+AV GTAVTPASFSYAG Sbjct 61 LREYRDGDLDGAWYAIAATDDPRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQS---SDVLSGGVALVGGGPGDPELITV 177 LSVGVLAGGEHRRSAAIRSAIREALQ GVIT + SD + GGVAL+GGGPGDPELITV Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDAVKGGVALIGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+IERAR+G Sbjct 181 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 +FVVRLKGGDPFVFARGYEEVLACA AGIPVTVVPGVTSAI VPA+AGVPVTHRA+ HEF Sbjct 241 SFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGHL PGHPESLVNWDALAALTGTIVLLMAVERIELF + LLKGGR ADTPVLVVQH Sbjct 301 VVVSGHLPPGHPESLVNWDALAALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 GTTAAQ TLRATLADTPEK+RA GIRPPAIIVIGAV Sbjct 361 GTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAV 396 >gi|254776133|ref|ZP_05217649.1| uroporphyrin-III C-methyltransferase [Mycobacterium avium subsp. avium ATCC 25291] Length=401 Score = 649 bits (1675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/396 (89%), Positives = 366/396 (93%), Gaps = 3/396 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+ YLVGLRL GKKVVVVGGGTVAQRRLPLLIASGADVHVI+ S T +VEAM ITL Sbjct 1 MTESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLQ 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDLDGAWYAIAATDD RVN AVVAEAERRRIFCVRAD+AV GTAVTPASFSYAG Sbjct 61 LREYRDGDLDGAWYAIAATDDPRVNEAVVAEAERRRIFCVRADVAVAGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQS---SDVLSGGVALVGGGPGDPELITV 177 LSVGVLAGGEHRRSAAIRSAIREALQ G IT + SD + GGVAL+GGGPGDPELITV Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQTGAITPEGPVGSDAVKGGVALIGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+IERAR+G Sbjct 181 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 +FVVRLKGGDPFVFARGYEEVLACA AGIPVTVVPGVTSAI VPA+AGVPVTHRA+ HEF Sbjct 241 SFVVRLKGGDPFVFARGYEEVLACADAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGHL PGHPESLVNWDALAALTGTIVLLMAVERIELF + LLKGGR ADTPVLVVQH Sbjct 301 VVVSGHLPPGHPESLVNWDALAALTGTIVLLMAVERIELFAEALLKGGRPADTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 GTTAAQ TLRATLADTPEK+RA GIRPPAIIVIGAV Sbjct 361 GTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAV 396 >gi|254819682|ref|ZP_05224683.1| uroporphyrin-III C-methyltransferase [Mycobacterium intracellulare ATCC 13950] Length=401 Score = 648 bits (1671), Expect = 0.0, Method: Compositional matrix adjust. Identities = 347/396 (88%), Positives = 367/396 (93%), Gaps = 3/396 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+ YLVGLRL GKKVVVVGGGTVAQRRLPLLIASGADVHVI+ S T +VEAM ITL+ Sbjct 1 MTESAYLVGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEAMTGITLA 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDLDGAWYAIAATDD RVN AVVAEAE R+IFCVRADIAVEGTAVTPASFSYAG Sbjct 61 LREYRDGDLDGAWYAIAATDDPRVNEAVVAEAESRQIFCVRADIAVEGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQS---SDVLSGGVALVGGGPGDPELITV 177 LSVGVLAGGEHRRSAAIRSAIREALQ GVIT + SD + GGVAL+GGGPGDPELITV Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQTGVITPEGPVGSDAVKGGVALIGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+IERAR+G Sbjct 181 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 +FVVRLKGGDPFVFARGYEEVLACA AGIPVTVVPGVTSAI VPA+AGVPVTHRA+ HEF Sbjct 241 SFVVRLKGGDPFVFARGYEEVLACAEAGIPVTVVPGVTSAIGVPALAGVPVTHRAINHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGHL PGHPESLVNWDALAA++GTIVLLMAVERIELF + LL GGR ADTPVLVVQH Sbjct 301 VVVSGHLPPGHPESLVNWDALAAMSGTIVLLMAVERIELFAEALLAGGRPADTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 GTTAAQ TLRATLADTPEK+RA GIRPPAIIVIGAV Sbjct 361 GTTAAQHTLRATLADTPEKIRAEGIRPPAIIVIGAV 396 >gi|342858321|ref|ZP_08714976.1| uroporphyrin-III C-methyltransferase [Mycobacterium colombiense CECT 3035] gi|342134025|gb|EGT87205.1| uroporphyrin-III C-methyltransferase [Mycobacterium colombiense CECT 3035] Length=401 Score = 647 bits (1670), Expect = 0.0, Method: Compositional matrix adjust. Identities = 347/396 (88%), Positives = 366/396 (93%), Gaps = 3/396 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+ YL GLRL GKKVVVVGGGTVAQRRLPLLIASGADVHVI+ S T +VE M ITL+ Sbjct 1 MTESAYLAGLRLTGKKVVVVGGGTVAQRRLPLLIASGADVHVISRSATRSVEVMTGITLA 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDLDGAWYAIAATDDARVN AVVAEAE RRIFCVRADIAVEGTAVTPASF YAG Sbjct 61 LREYRDGDLDGAWYAIAATDDARVNEAVVAEAESRRIFCVRADIAVEGTAVTPASFDYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQS---SDVLSGGVALVGGGPGDPELITV 177 LSVGVLAGG+HRRSAAIRSAIREALQ G+IT S SDV+ GGVALVGGGPGDPELITV Sbjct 121 LSVGVLAGGDHRRSAAIRSAIREALQTGLITPDSPVGSDVVKGGVALVGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+IERAR+G Sbjct 181 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERARAG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 +FVVRLKGGDPFVFARGYEEVLAC AGIPVTVVPGVTSAI VPA+AGVPVTHRA+ HEF Sbjct 241 SFVVRLKGGDPFVFARGYEEVLACVEAGIPVTVVPGVTSAIGVPALAGVPVTHRAINHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGHL PGHPESLVNWDALAA++GTIVLLMAVERIELF D LLKGGR ADTPVLVVQH Sbjct 301 VVVSGHLPPGHPESLVNWDALAAMSGTIVLLMAVERIELFADALLKGGRPADTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 GTTAAQ TLRATLADTPEK+RA GIRPPAI+VIGAV Sbjct 361 GTTAAQHTLRATLADTPEKIRAEGIRPPAIVVIGAV 396 >gi|183981899|ref|YP_001850190.1| multifunctional enzyme siroheme synthase CysG [Mycobacterium marinum M] gi|183175225|gb|ACC40335.1| multifunctional enzyme siroheme synthase CysG [Mycobacterium marinum M] Length=401 Score = 647 bits (1669), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/399 (85%), Positives = 368/399 (93%), Gaps = 3/399 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+PYLVGLRL G+KVVVVGGGTVAQRRLPLLIASGADV VI+ S T +VE MD+ITL+ Sbjct 1 MTESPYLVGLRLTGRKVVVVGGGTVAQRRLPLLIASGADVQVISRSATRSVEVMDKITLT 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDL+GAWYAIAATDD VN A+VAEA+RR+IFCVRADIAVEGTAVTPA+F++AG Sbjct 61 LREYRDGDLEGAWYAIAATDDPAVNAAIVAEADRRQIFCVRADIAVEGTAVTPATFNHAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITA---QSSDVLSGGVALVGGGPGDPELITV 177 LSVGVLA G+HRRSAAIRSAIREALQ G++T+ QSSDV+ GGVAL+GGGPGDPELITV Sbjct 121 LSVGVLASGDHRRSAAIRSAIREALQNGLVTSTSYQSSDVIRGGVALIGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+IERA++G Sbjct 181 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERAKAG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 FVVRLKGGDPFVFARGYEEVLAC AGIPV VVPGVTSAIAVPA+AGVPVTHRA HEF Sbjct 241 RFVVRLKGGDPFVFARGYEEVLACTEAGIPVIVVPGVTSAIAVPALAGVPVTHRATNHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGH+AP HPESLVNW+ALAA++GTIVLLMAVERIELFV+ LLKGGR ADTPVLVVQH Sbjct 301 VVVSGHIAPDHPESLVNWNALAAMSGTIVLLMAVERIELFVEALLKGGRPADTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGL 396 GTT AQ TLRATLADTPEKVRA GIRPPAIIVIGAV Sbjct 361 GTTPAQHTLRATLADTPEKVRAEGIRPPAIIVIGAVAAF 399 >gi|296171594|ref|ZP_06852834.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894049|gb|EFG73811.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=401 Score = 646 bits (1667), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/396 (87%), Positives = 364/396 (92%), Gaps = 3/396 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TEN YL GLRLAGKKVVVVGGG+VAQRRLPLLIASGADVHVI+ S T +VEAMD ITLS Sbjct 1 MTENAYLAGLRLAGKKVVVVGGGSVAQRRLPLLIASGADVHVISRSATRSVEAMDGITLS 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDLDGAWYAIAATDD +VN A+VAEAERR +FCVRAD+AVEGTAVTPASF YAG Sbjct 61 LREYRDGDLDGAWYAIAATDDPQVNAAIVAEAERRHLFCVRADVAVEGTAVTPASFGYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVIT---AQSSDVLSGGVALVGGGPGDPELITV 177 LSVGVLAGGEHRRSAAIRSAIREALQ GVIT A S DV+ GGVALVGGGPGDPELITV Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQTGVITPDSATSPDVVRGGVALVGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLA ADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+I+RARSG Sbjct 181 RGRRLLAHADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIDRARSG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 FVVRLKGGDPFVFARGYEEV AC AGIPVTVVPGVTSAI VPA+AGVPVTHRA+ HEF Sbjct 241 KFVVRLKGGDPFVFARGYEEVQACVDAGIPVTVVPGVTSAIGVPALAGVPVTHRAVNHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGHL PGHPESLVNW+AL A++GTIVLLMAVERIELF D L+KGGR ADTPVLVVQH Sbjct 301 VVVSGHLPPGHPESLVNWNALGAMSGTIVLLMAVERIELFADALIKGGRPADTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 GTTA+QQTLRATLADTPEK+RA GIRPPAIIVIG V Sbjct 361 GTTASQQTLRATLADTPEKIRAEGIRPPAIIVIGPV 396 >gi|118617674|ref|YP_906006.1| multifunctional enzyme siroheme synthase CysG [Mycobacterium ulcerans Agy99] gi|118569784|gb|ABL04535.1| multifunctional enzyme siroheme synthase CysG [Mycobacterium ulcerans Agy99] Length=401 Score = 643 bits (1659), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/396 (85%), Positives = 367/396 (93%), Gaps = 3/396 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TE+PYLVGLRL G+KVVVVGGGTVAQRRLPLLIASGADV VI+ S T +VE MD+ITL+ Sbjct 1 MTESPYLVGLRLTGRKVVVVGGGTVAQRRLPLLIASGADVQVISRSATRSVEVMDKITLT 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R+YRDGDL+GAWYAIAATDD VN A+VAEA+RR+IFCVRADIAVEGTAVTPA+F++AG Sbjct 61 LREYRDGDLEGAWYAIAATDDPAVNAAIVAEADRRQIFCVRADIAVEGTAVTPATFNHAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITA---QSSDVLSGGVALVGGGPGDPELITV 177 LSVGVLA G+HRRSAAIRSAIREALQ G++T+ QSSDV+ GGVAL+GGGPGDPELITV Sbjct 121 LSVGVLASGDHRRSAAIRSAIREALQNGLVTSTSYQSSDVIRGGVALIGGGPGDPELITV 180 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAIN V+IERA++G Sbjct 181 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINDVMIERAKAG 240 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 FVVRLKGGDPFVFARGYEEVLAC AGIPV VVPGVTSAIAVPA+AGVPVTHRA HEF Sbjct 241 RFVVRLKGGDPFVFARGYEEVLACTEAGIPVIVVPGVTSAIAVPALAGVPVTHRATNHEF 300 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGH+AP HPESLVNW+ALAA++GTIVLLMAVERIELFV+ LLKGGR A TPVLVVQH Sbjct 301 VVVSGHIAPDHPESLVNWNALAAMSGTIVLLMAVERIELFVEALLKGGRPAYTPVLVVQH 360 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 GTT AQ TLRATLADTPEKVRA GIRPPAIIVIGAV Sbjct 361 GTTPAQHTLRATLADTPEKVRAEGIRPPAIIVIGAV 396 >gi|108799041|ref|YP_639238.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. MCS] gi|119868156|ref|YP_938108.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. KMS] gi|126434644|ref|YP_001070335.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. JLS] gi|108769460|gb|ABG08182.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. MCS] gi|119694245|gb|ABL91318.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. KMS] gi|126234444|gb|ABN97844.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. JLS] Length=398 Score = 640 bits (1650), Expect = 0.0, Method: Compositional matrix adjust. Identities = 328/398 (83%), Positives = 354/398 (89%), Gaps = 0/398 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +T+N YLVGLRLAG+KVV+VGGGTVAQRRLPLLIA+GADVHVIA + TPAVEAM ITL+ Sbjct 1 MTDNAYLVGLRLAGRKVVIVGGGTVAQRRLPLLIANGADVHVIARAATPAVEAMTGITLT 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +RD+R GDLDGAWY IAATDD VN AVVAEAERR +FCVRAD+A EGTAVTPASF Y G Sbjct 61 LRDFRVGDLDGAWYVIAATDDPDVNAAVVAEAERRHVFCVRADVAREGTAVTPASFEYEG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 LSVGVLAGGEHRRSAAIRSAI EAL G+I+ D ++ GVALVGGGPGDPELITVRGR Sbjct 121 LSVGVLAGGEHRRSAAIRSAIHEALASGLISGDDPDTVTTGVALVGGGPGDPELITVRGR 180 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 RLLAQADVVVADRLAP ELLAELPPHVEVIDAAKIPYGRAMAQDAIN VLI+RA +G FV Sbjct 181 RLLAQADVVVADRLAPQELLAELPPHVEVIDAAKIPYGRAMAQDAINQVLIDRASAGKFV 240 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDPFVFARGYEEVLAC AGIPVTVVPGVTSAI VPA+AGVPVTHR +THEFVVV Sbjct 241 VRLKGGDPFVFARGYEEVLACVDAGIPVTVVPGVTSAIGVPALAGVPVTHRHVTHEFVVV 300 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 SGH+AP HPESLVNWDALAALTGTIVLLMAVERIELF VL++GGR A+TPVLVVQHGTT Sbjct 301 SGHVAPDHPESLVNWDALAALTGTIVLLMAVERIELFTKVLIEGGRPAETPVLVVQHGTT 360 Query 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSG 398 AQ+TLRATLAD PE++ A GIRPPAIIVIG V G Sbjct 361 TAQRTLRATLADAPERMSAEGIRPPAIIVIGPVAAFGG 398 >gi|145224627|ref|YP_001135305.1| uroporphyrin-III C-methyltransferase [Mycobacterium gilvum PYR-GCK] gi|315444959|ref|YP_004077838.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. Spyr1] gi|145217113|gb|ABP46517.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium gilvum PYR-GCK] gi|315263262|gb|ADU00004.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium sp. Spyr1] Length=403 Score = 623 bits (1607), Expect = 2e-176, Method: Compositional matrix adjust. Identities = 325/397 (82%), Positives = 362/397 (92%), Gaps = 3/397 (0%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVR 62 +N YLVGLRL+GKKVVVVGGGTVAQRRLPLL+++GADVHV+ + TPAVEA+D ITL++R Sbjct 5 DNAYLVGLRLSGKKVVVVGGGTVAQRRLPLLVSNGADVHVVTKAATPAVEAIDGITLTLR 64 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 ++RD DLDGAWY IAATDD VN A+VA AERRRIFCVRADIAVEGTAVTPA+F Y GL Sbjct 65 EFRDEDLDGAWYVIAATDDPAVNAAIVAGAERRRIFCVRADIAVEGTAVTPATFEYEGLE 124 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSD---VLSGGVALVGGGPGDPELITVRG 179 VGVLAGGEHRRSAAIR+AIREALQQGV+T +S D V+ GGVALVGGGPGDPELITVRG Sbjct 125 VGVLAGGEHRRSAAIRTAIREALQQGVVTDESGDAPGVVKGGVALVGGGPGDPELITVRG 184 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA ADVVVADRLAP ELLAEL P VEVIDA+KIPYGRAMAQDAINAVL++RA++G F Sbjct 185 RRLLAHADVVVADRLAPQELLAELSPEVEVIDASKIPYGRAMAQDAINAVLVDRAKAGKF 244 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDPFVFARGYEEV+ACA AGIPVTVVPGVTSAIAVPA+AGVPVTHR +THEFVV Sbjct 245 VVRLKGGDPFVFARGYEEVIACAEAGIPVTVVPGVTSAIAVPALAGVPVTHRGLTHEFVV 304 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGHLAP HPESLVNWDALAA++GTIVLLMAVERIELFV VLLKGGR ADTPVLVVQHGT Sbjct 305 VSGHLAPDHPESLVNWDALAAMSGTIVLLMAVERIELFVKVLLKGGRPADTPVLVVQHGT 364 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGL 396 T++Q+TLRA L++ PE++R+ GIRPPAI+VIGAV G Sbjct 365 TSSQRTLRAGLSEVPERIRSDGIRPPAIVVIGAVAGF 401 >gi|333991211|ref|YP_004523825.1| multifunctional enzyme siroheme synthase CysG [Mycobacterium sp. JDM601] gi|333487179|gb|AEF36571.1| multifunctional enzyme siroheme synthase CysG [Mycobacterium sp. JDM601] Length=405 Score = 617 bits (1591), Expect = 1e-174, Method: Compositional matrix adjust. Identities = 331/403 (83%), Positives = 353/403 (88%), Gaps = 7/403 (1%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQ---- 56 +TENPYLVGLRLAG+KVVVVG G VAQRRLPLL+ SGA V VIAP TP+VEA+ + Sbjct 1 MTENPYLVGLRLAGRKVVVVGAGGVAQRRLPLLVDSGAQVVVIAPGATPSVEALGERKPG 60 Query 57 ITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASF 116 ITL R YRDGDL AWYAIAATDD VN AVVAEA+RRRIFCVRAD+AVEG+AVTPASF Sbjct 61 ITLVSRAYRDGDLTDAWYAIAATDDPDVNAAVVAEADRRRIFCVRADLAVEGSAVTPASF 120 Query 117 SYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQ---SSDVLSGGVALVGGGPGDPE 173 SYAGLSVGVLAGGEH RSAAIRSAIREALQ G+I +SDV+ GGVALVGGGPGDPE Sbjct 121 SYAGLSVGVLAGGEHSRSAAIRSAIREALQSGLIAMDVEATSDVVRGGVALVGGGPGDPE 180 Query 174 LITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIER 233 LITVRGRR+L+ ADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINA++IER Sbjct 181 LITVRGRRMLSHADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINALMIER 240 Query 234 ARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAM 293 A +G FVVRLKGGDPFVFARGYEEVLAC AGIPVTVVPGVTSAIAVPA AGVPVTHRA+ Sbjct 241 AAAGKFVVRLKGGDPFVFARGYEEVLACTDAGIPVTVVPGVTSAIAVPAQAGVPVTHRAV 300 Query 294 THEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVL 353 HEFVVVSGH+AP PESLVNWDALAA+ GTIVLLMAVERIE F VL KGGR ADTPVL Sbjct 301 NHEFVVVSGHIAPDDPESLVNWDALAAMRGTIVLLMAVERIEQFSAVLQKGGRPADTPVL 360 Query 354 VVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGL 396 VVQHGTT AQ TLRATLAD PEK+RA GIRPPAI+VIGAV G Sbjct 361 VVQHGTTPAQHTLRATLADAPEKIRAEGIRPPAIVVIGAVAGF 403 >gi|120403296|ref|YP_953125.1| uroporphyrin-III C-methyltransferase [Mycobacterium vanbaalenii PYR-1] gi|119956114|gb|ABM13119.1| uroporphyrinogen-III C-methyltransferase [Mycobacterium vanbaalenii PYR-1] Length=402 Score = 613 bits (1582), Expect = 1e-173, Method: Compositional matrix adjust. Identities = 323/398 (82%), Positives = 356/398 (90%), Gaps = 3/398 (0%) Query 2 TENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSV 61 +EN YLVGLRLAGKKVVVVGGGTVAQRRLPLL+ASGADVHVI + TPAVEA+D ITL++ Sbjct 3 SENAYLVGLRLAGKKVVVVGGGTVAQRRLPLLVASGADVHVITRAATPAVEAIDGITLTM 62 Query 62 RDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGL 121 RD+R GDL+GAWY IAATDD VN A+VAEAE RR+FCVRAD+AVEGTAVTPA+F Y GL Sbjct 63 RDFRAGDLEGAWYVIAATDDPEVNAAIVAEAESRRVFCVRADVAVEGTAVTPATFEYEGL 122 Query 122 SVGVLAGGEHRRSAAIRSAIREALQQGVITAQSS---DVLSGGVALVGGGPGDPELITVR 178 SVGVLAGGEHRRSA IR+AIREALQ+G+I SS V G VALVGGGPGDPEL+TVR Sbjct 123 SVGVLAGGEHRRSAGIRTAIREALQRGLIGVDSSAAPGVAKGTVALVGGGPGDPELVTVR 182 Query 179 GRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGN 238 GRRLLA ADVVVADRLAP +LL+EL P VEVIDAAKIPYGRAMAQDAIN VLI RAR G Sbjct 183 GRRLLAHADVVVADRLAPQDLLSELSPEVEVIDAAKIPYGRAMAQDAINEVLIARAREGK 242 Query 239 FVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFV 298 FVVRLKGGDPFVFARGYEEV+ACA AGIPVTVVPGVTSAIAVPA+AGVPVTHR +THEFV Sbjct 243 FVVRLKGGDPFVFARGYEEVIACAEAGIPVTVVPGVTSAIAVPALAGVPVTHRGLTHEFV 302 Query 299 VVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHG 358 VVSGH+AP HPESLVNWDALAA+ GTIVLLMAVERIELFV +LL+GGR ADTPVLVVQHG Sbjct 303 VVSGHVAPDHPESLVNWDALAAMNGTIVLLMAVERIELFVKILLRGGRPADTPVLVVQHG 362 Query 359 TTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGL 396 TT++Q+TLRATL++ PE++R+ GIRPPAIIVIGAV G Sbjct 363 TTSSQRTLRATLSEAPERIRSDGIRPPAIIVIGAVAGF 400 >gi|118472829|ref|YP_886955.1| uroporphyrin-III C-methyltransferase [Mycobacterium smegmatis str. MC2 155] gi|118174116|gb|ABK75012.1| uroporphyrin-III C-methyltransferase [Mycobacterium smegmatis str. MC2 155] Length=402 Score = 608 bits (1567), Expect = 6e-172, Method: Compositional matrix adjust. Identities = 324/402 (81%), Positives = 356/402 (89%), Gaps = 4/402 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQ---- 56 +TE+ YLVGLRL+GKKVVVVGGGTVAQRRLPLL+A+GADVHVI + TP VEA+ + Sbjct 1 MTEDAYLVGLRLSGKKVVVVGGGTVAQRRLPLLLANGADVHVITRAATPVVEALQKDDPG 60 Query 57 ITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASF 116 ITL +RD+R GDL+GAWY IAATDD VN A+ AEA+ RRIFCVRADIA EG+AVTPA+F Sbjct 61 ITLELRDFRPGDLEGAWYVIAATDDPVVNAAIAAEADERRIFCVRADIAREGSAVTPATF 120 Query 117 SYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELIT 176 + GLSVGVLAGGEHRRSAAIRSAI EALQQG++T L+ GVALVGGGPGDPELIT Sbjct 121 EHDGLSVGVLAGGEHRRSAAIRSAIHEALQQGLVTEDMPGELTSGVALVGGGPGDPELIT 180 Query 177 VRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARS 236 VRGRRLLA+ADVVVADRLAP ELLAEL PHVEVIDAAKIPYGRAMAQ+AINAVLIERAR+ Sbjct 181 VRGRRLLARADVVVADRLAPQELLAELGPHVEVIDAAKIPYGRAMAQEAINAVLIERARA 240 Query 237 GNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHE 296 G FVVRLKGGDPFVFARGYEEVLAC+ AGIPVTVVPGVTSAIAVPA+AGVPVTHR MTHE Sbjct 241 GKFVVRLKGGDPFVFARGYEEVLACSEAGIPVTVVPGVTSAIAVPALAGVPVTHRGMTHE 300 Query 297 FVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQ 356 FVVVSGH+APGHPESLVNWDALAA+ GTIVLLMAVERIE F VLL+GGR ADTPVLVVQ Sbjct 301 FVVVSGHVAPGHPESLVNWDALAAMRGTIVLLMAVERIEQFAKVLLEGGRPADTPVLVVQ 360 Query 357 HGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSG 398 HGTT AQ+TL ATLAD PE++R+ GIRPPAIIVIG V G +G Sbjct 361 HGTTMAQRTLHATLADAPERIRSEGIRPPAIIVIGPVAGFAG 402 >gi|289571035|ref|ZP_06451262.1| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis T17] gi|289544789|gb|EFD48437.1| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis T17] Length=300 Score = 583 bits (1504), Expect = 1e-164, Method: Compositional matrix adjust. Identities = 299/300 (99%), Positives = 300/300 (100%), Gaps = 0/300 (0%) Query 106 VEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALV 165 +EGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALV Sbjct 1 MEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALV 60 Query 166 GGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDA 225 GGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDA Sbjct 61 GGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDA 120 Query 226 INAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAG 285 INAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAG Sbjct 121 INAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAG 180 Query 286 VPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGG 345 VPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGG Sbjct 181 VPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGG 240 Query 346 RTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 405 RTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS Sbjct 241 RTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS 300 >gi|169630225|ref|YP_001703874.1| multifunctional siroheme synthase CysG/uroporphyrin-III C-methyltransferase-like protein [Mycobacterium abscessus ATCC 19977] gi|169242192|emb|CAM63220.1| Possible multifunctional enzyme siroheme synthase CysG/Uroporphyrin-III C-methyltransferase-like [Mycobacterium abscessus] Length=398 Score = 579 bits (1493), Expect = 2e-163, Method: Compositional matrix adjust. Identities = 309/393 (79%), Positives = 341/393 (87%), Gaps = 1/393 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +T + YLVGLRLAG+KVVVVG G+VAQRRL LLIASGADVHVIAP TPAVE M I L Sbjct 1 MTHDAYLVGLRLAGRKVVVVGAGSVAQRRLGLLIASGADVHVIAPHATPAVEGMASINLQ 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 +R Y+DGDLDGAWYAIA TDD VN AVV EAERR IFCVRAD A +GTAVTPASF++ G Sbjct 61 LRPYQDGDLDGAWYAIACTDDPAVNAAVVDEAERRHIFCVRADSARDGTAVTPASFNHDG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 ++VGVL GG+H+RSAA+RSAI EALQ+G+IT +++DV GVALVGGGPGDP+LITVRGR Sbjct 121 IAVGVLTGGQHKRSAALRSAIHEALQRGLIT-ETADVKPEGVALVGGGPGDPDLITVRGR 179 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 RLLAQADVVVADRLAP ELLA+L PHVEVIDAAKIPYGRAMAQ IN VLIERA+ G FV Sbjct 180 RLLAQADVVVADRLAPAELLADLGPHVEVIDAAKIPYGRAMAQQEINRVLIERAQEGKFV 239 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDPFVFARGYEEVLACA AG+ VTVVPGVTSAI+VPA AGVPVTHRA+ HEFVVV Sbjct 240 VRLKGGDPFVFARGYEEVLACAEAGVQVTVVPGVTSAISVPAAAGVPVTHRAVNHEFVVV 299 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 SGH+APGHPESLVNWDALAAL GTIVLLMAVERIE F VL++GGR A TPVLVVQHGTT Sbjct 300 SGHVAPGHPESLVNWDALAALNGTIVLLMAVERIEQFARVLIEGGRPAHTPVLVVQHGTT 359 Query 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAV 393 Q+ LRA LA PE++R+ GIRPPAIIVIG V Sbjct 360 DEQRVLRADLATAPERIRSQGIRPPAIIVIGPV 392 >gi|229491428|ref|ZP_04385252.1| uroporphyrin-III C-methyltransferase [Rhodococcus erythropolis SK121] gi|229321713|gb|EEN87510.1| uroporphyrin-III C-methyltransferase [Rhodococcus erythropolis SK121] Length=408 Score = 534 bits (1375), Expect = 1e-149, Method: Compositional matrix adjust. Identities = 276/398 (70%), Positives = 323/398 (82%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL L ++VVV GGGTVAQRRL LL+ASGA VHVI+ + TPAVE M QIT+ Sbjct 8 ETNYLVGLNLTDRRVVVFGGGTVAQRRLGLLVASGARVHVISRAFTPAVEGMATAGQITV 67 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 R Y DGDL+GAWYAIA+TD+ N A+VAEAERR IFCVRAD A GTAVTPAS Y Sbjct 68 EERPYADGDLEGAWYAIASTDEPETNAAIVAEAERRHIFCVRADNAKHGTAVTPASAEYD 127 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 G+S+G+LAGG+HRRSAA+R+A+ E LQ GV+ A +++ + GVALVGGGPGDP+LITVRG Sbjct 128 GMSIGILAGGDHRRSAAVRTAVVEGLQSGVL-ADTAEPAAAGVALVGGGPGDPDLITVRG 186 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRLAPPELLAEL P VEVIDAAKIPYGRAMAQ+AINA LI+ A++G F Sbjct 187 RRLLARADVVVADRLAPPELLAELGPDVEVIDAAKIPYGRAMAQEAINAALIDNAKAGKF 246 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP+VF RGYEE+ ACA AG+PVTVVPG+TSAI+VP+ AG+PVTHR +THEFVV Sbjct 247 VVRLKGGDPYVFGRGYEELEACAAAGVPVTVVPGITSAISVPSAAGIPVTHRGVTHEFVV 306 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP HP+SLV+W ALA L GTIVLLMAVERI+ F L+ GGR A TPV V+Q GT Sbjct 307 VSGHVAPDHPDSLVDWSALAKLRGTIVLLMAVERIDQFAKSLVDGGRPATTPVTVIQEGT 366 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ LRA LA ++V+ I+PPAIIVIG V G S Sbjct 367 LRTQRELRADLATVAQRVKDEEIKPPAIIVIGPVAGFS 404 >gi|312139292|ref|YP_004006628.1| uroporphyrinogen-III C-methyltransferase [Rhodococcus equi 103S] gi|311888631|emb|CBH47943.1| uroporphyrinogen-III C-methyltransferase CysG [Rhodococcus equi 103S] Length=408 Score = 533 bits (1372), Expect = 2e-149, Method: Compositional matrix adjust. Identities = 284/398 (72%), Positives = 330/398 (83%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL L ++VVVVGGGTVAQRRL LL+ASGADVHV++ VTPAVE M QITL Sbjct 8 ETSYLVGLNLTDRRVVVVGGGTVAQRRLGLLVASGADVHVVSREVTPAVEGMATSGQITL 67 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 +RDYRDGDLDGAWYAIA+TD+ N A+VAEAER RIFCVRAD A +GTAVTPA+ S+ Sbjct 68 ELRDYRDGDLDGAWYAIASTDEPDTNAAIVAEAERGRIFCVRADSARDGTAVTPATGSFD 127 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 GLS+GVLAGG HRRSAA+R+A+ EALQ G +T + + + GVALVGGGPGDP+LITVRG Sbjct 128 GLSLGVLAGGAHRRSAAVRTALIEALQSGAVT-DTDEAPAPGVALVGGGPGDPDLITVRG 186 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRLAPPELLAEL PHVEV+DAAKIPYGRAMAQ+AINA L++ A++G F Sbjct 187 RRLLARADVVVADRLAPPELLAELGPHVEVVDAAKIPYGRAMAQEAINAALVDNAKAGKF 246 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP+VF RG+EE+ ACA AG+PVTVVPG+TSAI+VP+ AG+PVTHR +THEFVV Sbjct 247 VVRLKGGDPYVFGRGFEELEACAAAGVPVTVVPGITSAISVPSAAGIPVTHRGVTHEFVV 306 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP HP+SLV+W ALA L GTIVLLMAVERIE F VL+ GGR A+TPV V+Q GT Sbjct 307 VSGHVAPDHPDSLVDWAALAKLRGTIVLLMAVERIEQFAAVLVAGGRPAETPVTVIQEGT 366 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ LRA LA +VR IRPPAI+VIG V G S Sbjct 367 LRTQRVLRADLATVAARVREENIRPPAIVVIGTVAGFS 404 >gi|226306097|ref|YP_002766057.1| siroheme synthase CysG [Rhodococcus erythropolis PR4] gi|226185214|dbj|BAH33318.1| siroheme synthase CysG [Rhodococcus erythropolis PR4] Length=408 Score = 533 bits (1372), Expect = 3e-149, Method: Compositional matrix adjust. Identities = 275/398 (70%), Positives = 323/398 (82%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL L ++VVV GGGTVAQRRL LL+ASGA VHVI+ + TPAVE M QIT+ Sbjct 8 ETNYLVGLNLTDRRVVVFGGGTVAQRRLGLLVASGARVHVISRAFTPAVEGMATAGQITV 67 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 R Y DGDL+GAWYAIA+TD+ N A+VAEAERR IFCVRAD A GTAVTPAS Y Sbjct 68 EERPYADGDLEGAWYAIASTDEPETNAAIVAEAERRHIFCVRADNAKHGTAVTPASAEYD 127 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 G+S+G+LAGG+HRRSAA+R+A+ E LQ GV+ A +++ + GVALVGGGPGDP+LITVRG Sbjct 128 GMSIGILAGGDHRRSAAVRTAVVEGLQSGVL-ADTAEPAAAGVALVGGGPGDPDLITVRG 186 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRLAPPELLAEL P VEVIDAAKIPYGRAMAQ+AINA LI+ A++G F Sbjct 187 RRLLARADVVVADRLAPPELLAELGPDVEVIDAAKIPYGRAMAQEAINAALIDNAKAGKF 246 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP+VF RGYEE+ ACA AG+PVTVVPG+TSAI+VP+ AG+PVTHR +THEFVV Sbjct 247 VVRLKGGDPYVFGRGYEELEACAAAGVPVTVVPGITSAISVPSAAGIPVTHRGVTHEFVV 306 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP HP+SLV+W ALA L GTIVLLMAVERI+ F L+ GGR + TPV V+Q GT Sbjct 307 VSGHVAPDHPDSLVDWSALAKLRGTIVLLMAVERIDQFARALVDGGRPSTTPVTVIQEGT 366 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ LRA LA ++V+ I+PPAIIVIG V G S Sbjct 367 LRTQRELRADLATVAQRVKDEEIKPPAIIVIGPVAGFS 404 >gi|333919282|ref|YP_004492863.1| Siroheme synthase CysG [Amycolicicoccus subflavus DQS3-9A1] gi|333481503|gb|AEF40063.1| Siroheme synthase CysG [Amycolicicoccus subflavus DQS3-9A1] Length=416 Score = 530 bits (1365), Expect = 2e-148, Method: Compositional matrix adjust. Identities = 280/400 (70%), Positives = 318/400 (80%), Gaps = 5/400 (1%) Query 3 ENP-YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQIT 58 +NP YL GL LAG++VVV+GGG+VAQRR+PLL++ GA+V VI T AVE M IT Sbjct 4 DNPVYLAGLALAGRRVVVIGGGSVAQRRVPLLVSVGAEVEVITREATAAVEGMAASGHIT 63 Query 59 LSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSY 118 L++RDY GDL AWYAIA+T+D VN A+VAEAE RIFCVRAD A EGTAVTPAS SY Sbjct 64 LTLRDYAPGDLSDAWYAIASTNDPEVNAAIVAEAEELRIFCVRADNAREGTAVTPASMSY 123 Query 119 AGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSD-VLSGGVALVGGGPGDPELITV 177 GL+VGV+AGG+HRRSA+IRSAI EALQ GVI D GVALVGGGPGDP+LITV Sbjct 124 EGLNVGVVAGGDHRRSASIRSAILEALQSGVIDDHPEDGARRSGVALVGGGPGDPDLITV 183 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLAQADVVVADRLAPPELLAEL PHVEVIDA+KIPYGRAMAQ+AIN LI RAR+G Sbjct 184 RGRRLLAQADVVVADRLAPPELLAELGPHVEVIDASKIPYGRAMAQEAINDTLIARARAG 243 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 FVVRLKGGDP+VF RGYEE+LACA AGI VTVVPG+TSAIAVPA AGVPVTHR ++HEF Sbjct 244 KFVVRLKGGDPYVFGRGYEELLACAEAGISVTVVPGITSAIAVPAAAGVPVTHRGVSHEF 303 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGH+ PGHP+SLV+W AL + GTIVLLM VERI+ F L+ GGR TPV V+Q Sbjct 304 VVVSGHVPPGHPQSLVDWPALGRMKGTIVLLMGVERIDQFAAALIGGGRVETTPVTVIQE 363 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 GTT Q+ A L + E V+ IRPPAIIVIG V GL+ Sbjct 364 GTTRTQRVAHALLGNVAETVKQEEIRPPAIIVIGPVAGLA 403 >gi|325673402|ref|ZP_08153093.1| uroporphyrinogen-III C-methyltransferase [Rhodococcus equi ATCC 33707] gi|325555423|gb|EGD25094.1| uroporphyrinogen-III C-methyltransferase [Rhodococcus equi ATCC 33707] Length=408 Score = 529 bits (1362), Expect = 4e-148, Method: Compositional matrix adjust. Identities = 283/398 (72%), Positives = 329/398 (83%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL L ++VVVVGGGTVAQRRL LL+ASGADVHV++ VTPAVE M QITL Sbjct 8 ETSYLVGLNLTDRRVVVVGGGTVAQRRLGLLVASGADVHVVSREVTPAVEGMATSGQITL 67 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 +RDYRDGDLDGAWYAIA+TD+ N A+VAEAER RIFCVRAD A +GTAVTPA+ S+ Sbjct 68 ELRDYRDGDLDGAWYAIASTDEPDTNAAIVAEAERGRIFCVRADSARDGTAVTPATGSFD 127 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 GLS+GVLAGG HRRSAA+R+A+ EALQ G +T + + + GVALVGGGPGDP+LITVRG Sbjct 128 GLSLGVLAGGAHRRSAAVRTALIEALQSGAVT-DTDEAPAPGVALVGGGPGDPDLITVRG 186 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRLAPPELLAEL PHVEV+DAAKIPYGRAMAQ+AINA L++ A++G F Sbjct 187 RRLLARADVVVADRLAPPELLAELGPHVEVVDAAKIPYGRAMAQEAINAALVDNAKAGKF 246 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP+VF RG+EE+ ACA AG+PVTVVPG+TSAI+VP+ AG+PVTHR +THEFVV Sbjct 247 VVRLKGGDPYVFGRGFEELEACAAAGVPVTVVPGITSAISVPSAAGIPVTHRGVTHEFVV 306 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP HP+SLV+W ALA L GTIVLLMAVERIE F VL+ GGR A+T V V+Q GT Sbjct 307 VSGHVAPDHPDSLVDWAALAKLRGTIVLLMAVERIEQFAAVLVDGGRPAETLVTVIQEGT 366 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ LRA LA +VR IRPPAI+VIG V G S Sbjct 367 LRTQRVLRADLATVAARVREENIRPPAIVVIGTVAGFS 404 >gi|111023576|ref|YP_706548.1| uroporphyrin-III C-methyltransferase [Rhodococcus jostii RHA1] gi|110823106|gb|ABG98390.1| uroporphyrin-III C-methyltransferase [Rhodococcus jostii RHA1] Length=408 Score = 520 bits (1340), Expect = 2e-145, Method: Compositional matrix adjust. Identities = 281/398 (71%), Positives = 326/398 (82%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL LA ++VVVVGGGTVAQRRL LLIASGA VH+I+ +VTPAVE M QITL Sbjct 8 ETNYLVGLNLADRRVVVVGGGTVAQRRLGLLIASGARVHLISRAVTPAVEGMATAGQITL 67 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 +R+YRDGDL AWYAIA TD+ N A+VAEAER R+FCVRAD A GTAVTPAS SY Sbjct 68 ELREYRDGDLADAWYAIACTDEPDTNAAIVAEAERNRVFCVRADNARYGTAVTPASASYD 127 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 G+S+GVLAGG+HRRSAA+R+A+ E LQ G + A ++D + GVALVGGGPGDP+LITVRG Sbjct 128 GMSIGVLAGGDHRRSAAVRTALVEGLQSGAV-ADTADHPAAGVALVGGGPGDPDLITVRG 186 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRLAPPELLAEL VEVIDAAKIPYGRAMAQ+AINA LI+ A++G F Sbjct 187 RRLLARADVVVADRLAPPELLAELGSDVEVIDAAKIPYGRAMAQEAINAALIDGAKAGKF 246 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP+VF RGYEE+ ACA AG+PVTVVPG+TSAI+VP+ AG+PVTHR +THEFVV Sbjct 247 VVRLKGGDPYVFGRGYEELEACAAAGVPVTVVPGITSAISVPSAAGIPVTHRGVTHEFVV 306 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP HP+SLV+W ALA L GTIVLLMAVERIE F VL++GGR DTPV V+Q GT Sbjct 307 VSGHVAPDHPDSLVDWSALARLKGTIVLLMAVERIEAFATVLMEGGRPVDTPVTVIQEGT 366 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+T+RA L +V+ IRPPAI+VIG V G S Sbjct 367 LRTQRTVRADLQTVAARVKEEQIRPPAIVVIGPVAGFS 404 >gi|226366062|ref|YP_002783845.1| siroheme synthase CysG [Rhodococcus opacus B4] gi|226244552|dbj|BAH54900.1| siroheme synthase CysG [Rhodococcus opacus B4] Length=408 Score = 517 bits (1332), Expect = 1e-144, Method: Compositional matrix adjust. Identities = 279/398 (71%), Positives = 324/398 (82%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL LA ++VVVVGGGTVAQRRL LLIASGA VH+I+ VTPAVE M QIT+ Sbjct 8 ETNYLVGLNLADRRVVVVGGGTVAQRRLGLLIASGARVHLISREVTPAVEGMATAGQITV 67 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 +R+YRDGDL AWYAIA TD+ N A+VAEAER R+FCVRAD A GTAVTPAS SY Sbjct 68 DLREYRDGDLADAWYAIACTDEPDTNAAIVAEAERNRVFCVRADNARYGTAVTPASASYD 127 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 G+S+GVLAGG+HRRSAA+R+A+ E LQ G + A +++ + GVALVGGGPGDP+LITVRG Sbjct 128 GMSIGVLAGGDHRRSAAVRTALVEGLQSGAV-ADTAEPPAAGVALVGGGPGDPDLITVRG 186 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRLAPPELLAEL VEVIDAAKIPYGRAMAQ+AINA L++ A++G F Sbjct 187 RRLLARADVVVADRLAPPELLAELGSDVEVIDAAKIPYGRAMAQEAINAALVDGAKAGKF 246 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP+VF RGYEE+ ACA AG+PVTVVPG+TSAI+VP+ AG+PVTHR +THEFVV Sbjct 247 VVRLKGGDPYVFGRGYEELEACAAAGVPVTVVPGITSAISVPSAAGIPVTHRGVTHEFVV 306 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP HP+SLV+W ALA L GTIVLLMAVERIE F VL+ GGR DTPV V+Q GT Sbjct 307 VSGHVAPDHPDSLVDWSALARLKGTIVLLMAVERIEAFATVLMDGGRPVDTPVTVIQEGT 366 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+TLRA L +V+ IRPPAI+VIG V G S Sbjct 367 LRTQRTLRADLQTVAARVKEEQIRPPAIVVIGPVAGFS 404 >gi|324999818|ref|ZP_08120930.1| uroporphyrinogen-iii c-methyltransferase cysg [Pseudonocardia sp. P1] Length=406 Score = 487 bits (1254), Expect = 1e-135, Method: Compositional matrix adjust. Identities = 270/396 (69%), Positives = 315/396 (80%), Gaps = 6/396 (1%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 YLVGL L+G++VVVVGGG VAQRR LIA+GA V V++P VTPAVE M +IT S R Sbjct 8 YLVGLDLSGRRVVVVGGGQVAQRRTARLIAAGAVVEVVSPEVTPAVEGMVSAGEITWSAR 67 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y DGDLDGAWYAIAATDDA VN AV AEAERRR+FCVRAD GTAVTPA+ + GL+ Sbjct 68 GYADGDLDGAWYAIAATDDASVNTAVTAEAERRRVFCVRADDGSRGTAVTPATGLHDGLT 127 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 VGVLA G HRRSAA+R+A+ EALQ GV+ + +++ GVALVGGGPGDPELITVRGRRL Sbjct 128 VGVLARGAHRRSAAVRTALVEALQSGVVD-EDAELPQAGVALVGGGPGDPELITVRGRRL 186 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 L++A VVVADRL P +L+ ELPP VEVIDA+KIPYGRAMAQ+ IN +L+E AR+G FVVR Sbjct 187 LSRAQVVVADRLGPRDLMDELPPDVEVIDASKIPYGRAMAQEKINELLVENARAGRFVVR 246 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDPFV+ RG+EEV ACA AG+PVTVVPG+TSA A PA+AG PVTHR + HE VVVSG Sbjct 247 LKGGDPFVYGRGFEEVQACAAAGVPVTVVPGITSAFAAPAVAGTPVTHRGVAHEIVVVSG 306 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+AP P SL +W AL +TGTIVL+MAVER+ F D L+ GR ADTPVL+VQ GTT Sbjct 307 HVAPDDPRSLTDWTALGRMTGTIVLMMAVERLGRFADALITHGRAADTPVLIVQDGTTRI 366 Query 363 QQTLRATLADTPEKVRA-AGIRPPAIIVIGAVVGLS 397 Q+T+RATL +T EKV A A + PPAIIVIG V GL Sbjct 367 QRTVRATL-ETAEKVAAEAEVSPPAIIVIGPVAGLE 401 >gi|54026048|ref|YP_120290.1| putative uroporphyrinogen III methylase [Nocardia farcinica IFM 10152] gi|54017556|dbj|BAD58926.1| putative uroporphyrinogen III methyltransferase [Nocardia farcinica IFM 10152] Length=423 Score = 483 bits (1242), Expect = 3e-134, Method: Compositional matrix adjust. Identities = 284/410 (70%), Positives = 323/410 (79%), Gaps = 6/410 (1%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQI 57 V E YLVGL L G++VVVVGGGTVA RRL LLIA+GADVHVI+ VTP VE M QI Sbjct 12 VAEPHYLVGLDLRGRRVVVVGGGTVAARRLGLLIAAGADVHVISREVTPTVEGMASSGQI 71 Query 58 TLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFS 117 +++R Y DGDL AWYAIA TD+ N AVVAEAERRR+FCVRAD A GTAVTPA+ Sbjct 72 RVTLRPYADGDLAEAWYAIACTDEPETNAAVVAEAERRRVFCVRADNARLGTAVTPATAR 131 Query 118 YAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITV 177 Y GL++GVLA G HRRSAA+R+ + EALQ GV+ A S ++ GVALVGGGPGDP+LITV Sbjct 132 YEGLTLGVLARGAHRRSAAVRTGLLEALQSGVV-ADDSVPVTPGVALVGGGPGDPDLITV 190 Query 178 RGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSG 237 RGRRLLA+AD+VVADRLAPPELLAEL PHVEV+DAAKIPYGRAMAQ+AIN L+E AR+G Sbjct 191 RGRRLLARADMVVADRLAPPELLAELGPHVEVVDAAKIPYGRAMAQEAINTALVEGARAG 250 Query 238 NFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEF 297 FVVRLKGGDP+VF RGYEEV AC AG+PVTVVPGVTS I+VPA AG+PVTHR +THEF Sbjct 251 KFVVRLKGGDPYVFGRGYEEVQACVAAGVPVTVVPGVTSPISVPAAAGIPVTHRGVTHEF 310 Query 298 VVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQH 357 VVVSGH+AP HP+SLV+W ALA L GT+VL+MAVERIE F D LL GGR ADTP VVQ Sbjct 311 VVVSGHVAPDHPDSLVDWSALARLRGTLVLMMAVERIEQFADALLAGGRPADTPAAVVQE 370 Query 358 GTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIG--AVVGLSGVRGLNNS 405 GT Q+ LRA L +VRA GIRPPAIIVIG A L+ + L S Sbjct 371 GTLRTQRVLRADLGTVAARVRAEGIRPPAIIVIGPTAAFALADIGALTGS 420 >gi|296139417|ref|YP_003646660.1| uroporphyrin-III C-methyltransferase [Tsukamurella paurometabola DSM 20162] gi|296027551|gb|ADG78321.1| uroporphyrin-III C-methyltransferase [Tsukamurella paurometabola DSM 20162] Length=411 Score = 480 bits (1235), Expect = 2e-133, Method: Compositional matrix adjust. Identities = 260/397 (66%), Positives = 306/397 (78%), Gaps = 2/397 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 V +PYLVGL L G++VV+VG GTV QRRLP L+A+GADVHVIAP TPAVE+ IT Sbjct 6 VARDPYLVGLDLRGRRVVLVGAGTVVQRRLPPLLAAGADVHVIAPEATPAVESTVGITWH 65 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 R+Y DGDL GAWYA+AATDD VN VVAEA+ +R FCVRAD+A EGTAVTPA+ + G Sbjct 66 RREYADGDLAGAWYALAATDDPAVNARVVAEAQAQRTFCVRADLAREGTAVTPATVATDG 125 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 L VGVLA G+HRRSAA+R+A+ L A GVALVGGGPGDP+LITVRGR Sbjct 126 LQVGVLAAGDHRRSAAVRNALGAVLTGD--EAARPTRKPEGVALVGGGPGDPDLITVRGR 183 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFV 240 LLA ADVVVADRLAPP LLAEL PHVEVIDAAK+PYGRAMAQ AIN VLI+RAR G FV Sbjct 184 ALLAVADVVVADRLAPPRLLAELAPHVEVIDAAKVPYGRAMAQQAINQVLIDRAREGKFV 243 Query 241 VRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVV 300 VRLKGGDP+VF RGYEE+ A A GIPVTVVPG+TS+IA P+ AG+PVTHR +THEFVVV Sbjct 244 VRLKGGDPYVFGRGYEELEALAAEGIPVTVVPGITSSIAAPSAAGIPVTHRGVTHEFVVV 303 Query 301 SGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTT 360 SGH+APGHP+SLV+WDAL L GT+V+LMAVER+ + + L+ GGR +DTP VV+ TT Sbjct 304 SGHVAPGHPDSLVDWDALGRLRGTVVVLMAVERLGVIAEALIAGGRPSDTPAAVVESATT 363 Query 361 AAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+T+R TL AA + PPA++V+G V G + Sbjct 364 GGQRTVRGTLTTIAADSAAAEVAPPAVLVVGPVAGFT 400 >gi|331696542|ref|YP_004332781.1| uroporphyrin-III C-methyltransferase [Pseudonocardia dioxanivorans CB1190] gi|326951231|gb|AEA24928.1| uroporphyrin-III C-methyltransferase [Pseudonocardia dioxanivorans CB1190] Length=403 Score = 477 bits (1227), Expect = 2e-132, Method: Compositional matrix adjust. Identities = 264/398 (67%), Positives = 311/398 (79%), Gaps = 4/398 (1%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITL 59 E YLVGL LAG++VVVVGGG VAQRRLP LIASGA + V++P VTPAVE M +I+ Sbjct 3 EEHYLVGLDLAGRRVVVVGGGQVAQRRLPRLIASGAAIEVVSPQVTPAVEGMVSAGEISW 62 Query 60 SVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYA 119 + R Y DGDLDGAWYA+A TDD VN AV +EA+RRR+FCVRAD GTAVTPA+ + Sbjct 63 TERGYADGDLDGAWYAVACTDDPAVNRAVGSEAQRRRVFCVRADDGSAGTAVTPATGDHD 122 Query 120 GLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRG 179 GL+VGVLAGG HRRSAA+R+A+ EALQ GV+ + VL G VALVGGGPGDPELITVRG Sbjct 123 GLTVGVLAGGRHRRSAAVRTALVEALQAGVVDDAAGPVLPG-VALVGGGPGDPELITVRG 181 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLLA+ADVVVADRL P +LL +L PHVEV+DA+KIPYGRAMAQ IN +L+E A++G F Sbjct 182 RRLLARADVVVADRLGPRDLLDDLAPHVEVVDASKIPYGRAMAQQKINELLVEHAKAGRF 241 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDPFV+ RGYEEV AC AG+PVTVVPG+TSA A PA+AGVPV+HR + HE VV Sbjct 242 VVRLKGGDPFVYGRGYEEVQACTAAGVPVTVVPGITSAFAAPAVAGVPVSHRGVAHEIVV 301 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP P SL +W AL + GT+VL+MAVERI LF D L+ GR ADTPV V+Q GT Sbjct 302 VSGHVAPDDPRSLTDWAALGRMRGTVVLMMAVERIALFADALVTHGRPADTPVAVIQDGT 361 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 T Q++LR TL D +R I PPAI+V+G V GLS Sbjct 362 TRIQRSLRTTLRDVAADIREQEISPPAIVVVGPVAGLS 399 >gi|298526315|ref|ZP_07013724.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|298496109|gb|EFI31403.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] Length=244 Score = 474 bits (1219), Expect = 1e-131, Method: Compositional matrix adjust. Identities = 242/244 (99%), Positives = 243/244 (99%), Gaps = 0/244 (0%) Query 162 VALVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAM 221 +ALVGGGP DPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAM Sbjct 1 MALVGGGPRDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAM 60 Query 222 AQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVP 281 AQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVP Sbjct 61 AQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVP 120 Query 282 AMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVL 341 AMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVL Sbjct 121 AMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVL 180 Query 342 LKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRG 401 LKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRG Sbjct 181 LKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRG 240 Query 402 LNNS 405 LNNS Sbjct 241 LNNS 244 >gi|329939003|ref|ZP_08288377.1| uroporphyrin-III methyltransferase [Streptomyces griseoaurantiacus M045] gi|329301888|gb|EGG45781.1| uroporphyrin-III methyltransferase [Streptomyces griseoaurantiacus M045] Length=410 Score = 463 bits (1191), Expect = 3e-128, Method: Compositional matrix adjust. Identities = 250/409 (62%), Positives = 304/409 (75%), Gaps = 8/409 (1%) Query 1 VTENP-YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQ 56 + E+P Y VGLRLAG++VVV+GGG VAQRRLP LIA+GADVH+I+P+ TP+VEAM + Sbjct 1 MAEHPAYPVGLRLAGRRVVVLGGGQVAQRRLPALIAAGADVHLISPAATPSVEAMADTGE 60 Query 57 ITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASF 116 IT S R YR+GDLD AWYA+ AT D N A AEAERRR++CVR+D A TA TPA+ Sbjct 61 ITWSRRPYREGDLDEAWYALIATSDHEANTAASAEAERRRVWCVRSDDADAATAWTPATG 120 Query 117 SYAGLSVGVLA----GGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDP 172 G++V VL G + R +AA+R A+ E L+ G + A + GVALVGGGPGDP Sbjct 121 HSEGVTVAVLTTSARGRDPRHTAAVRDAVVEGLRDGTLVAPHHRTRTPGVALVGGGPGDP 180 Query 173 ELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIE 232 +LITVRGRRLLA+ADVV+ADRL P +LLAELPPHVEVIDAAKIPYGR MAQ+AIN LIE Sbjct 181 DLITVRGRRLLAEADVVIADRLGPRDLLAELPPHVEVIDAAKIPYGRYMAQEAINNALIE 240 Query 233 RARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRA 292 AR G VVRLKGGDP+VF RG EEV A A AGI TVVPG++S+I+VP AGVPVTHR Sbjct 241 HARQGKSVVRLKGGDPYVFGRGMEEVRALAEAGIACTVVPGISSSISVPGAAGVPVTHRG 300 Query 293 MTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPV 352 + HEF VVSGH+APG SLV+W ALA LTGT+V+LM V++I D L+ G+ TPV Sbjct 301 VAHEFTVVSGHVAPGDARSLVDWPALARLTGTLVILMGVDKIGRIADTLVAHGKDPGTPV 360 Query 353 LVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRG 401 ++Q GTTAAQ+ + ATLA E VR A ++PPA+IVIG VV + +G Sbjct 361 ALIQEGTTAAQRRVDATLATVEETVRTADVKPPAVIVIGPVVHVGPEKG 409 >gi|300786876|ref|YP_003767167.1| uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase [Amycolatopsis mediterranei U32] gi|299796390|gb|ADJ46765.1| uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase [Amycolatopsis mediterranei U32] gi|340528363|gb|AEK43568.1| uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase [Amycolatopsis mediterranei S699] Length=406 Score = 461 bits (1187), Expect = 9e-128, Method: Compositional matrix adjust. Identities = 241/400 (61%), Positives = 295/400 (74%), Gaps = 6/400 (1%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 YL GL+L G++VV++GGGTVAQRRLP LI +GA V +++P TP+V+ M ++ R Sbjct 6 YLSGLQLTGRRVVMIGGGTVAQRRLPRLIGAGARVELVSPHTTPSVQGMVDAGELVWHER 65 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y GDL AWYA+A T+D VN AV AEAER R+FCVRAD G+AVTPAS + GL Sbjct 66 PYAPGDLRDAWYALACTNDPEVNAAVCAEAERERVFCVRADEGESGSAVTPASGRHGGLL 125 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSG---GVALVGGGPGDPELITVRG 179 GVL+GGE RSAA+R ++ + L G I G GVALVGGGPGDPELITVRG Sbjct 126 FGVLSGGEPLRSAAVRDSMLDGLHNGTIEDGRQPHPEGTLPGVALVGGGPGDPELITVRG 185 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLL++ADVVV DRLAP ELL EL P VE++DAAKIPYGRA +QD IN+ LIERA+ G F Sbjct 186 RRLLSRADVVVVDRLAPRELLDELAPEVEIVDAAKIPYGRAASQDVINSTLIERAKEGKF 245 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP++F RG+EEVLACA AG+PVT+VPG+TSA AVPA+A VPVTHR + HE VV Sbjct 246 VVRLKGGDPYLFGRGFEEVLACAEAGVPVTMVPGITSAFAVPAVADVPVTHRGVAHEVVV 305 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+AP SLV+W+ LA + GTIVL+M VER+ F LL GGR ADTPV +++ GT Sbjct 306 VSGHVAPDDDRSLVDWELLARMKGTIVLMMGVERLPQFAKALLDGGRPADTPVAIIEDGT 365 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGV 399 Q++LR+TL A+G+RPPA+IVIG V GL+ V Sbjct 366 MRTQRSLRSTLDTVVTDAAASGVRPPAVIVIGPVAGLAPV 405 >gi|297155856|gb|ADI05568.1| uroporphyrin-III methyltransferase [Streptomyces bingchenggensis BCW-1] Length=406 Score = 452 bits (1162), Expect = 6e-125, Method: Compositional matrix adjust. Identities = 247/395 (63%), Positives = 296/395 (75%), Gaps = 3/395 (0%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 Y VGLRL+G++VVV+G G VAQRRLP LIA+GAD+ +I+PS T +VEAM ++ R Sbjct 7 YPVGLRLSGRRVVVLGAGQVAQRRLPALIAAGADIVLISPSATASVEAMAEAGEVRWERR 66 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y+DGD DGAWYA+ TDD + N A AEAE RR++CVR+D A TA TPA+ G++ Sbjct 67 KYQDGDFDGAWYALITTDDPQANAAASAEAEARRVWCVRSDDAEASTAWTPATGRSEGVT 126 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 V VL G + RRSAA+R A+ E L+ G + A VALVGGGPGDP+LITVRGRRL Sbjct 127 VAVLTGRDPRRSAAVRDAVVEGLRDGTLAAPRHRARGPHVALVGGGPGDPDLITVRGRRL 186 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 LA+ADVVVADRL P +LL ELPPHVEVIDAAKIPYGR MAQ+AIN LIE A++G VVR Sbjct 187 LAEADVVVADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINNALIEHAKAGKSVVR 246 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDPFVF RG EE A A AGIP TVVPGVTSAI+VPA+AG+PVTHR + HEF VVSG Sbjct 247 LKGGDPFVFGRGMEEAHALAEAGIPCTVVPGVTSAISVPAVAGIPVTHRGVAHEFTVVSG 306 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+AP P SLV+W ALA L GT+VLLMAVE+I L++ GR A+TPV VVQ GTTA Sbjct 307 HVAPDDPSSLVDWAALAKLRGTLVLLMAVEKIGSISATLIEHGRAANTPVAVVQEGTTAT 366 Query 363 QQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ + ATLA E+V A G+RPPA++VIG V L+ Sbjct 367 QRRVDATLATVAERVAAEGVRPPAVVVIGEVTALA 401 >gi|302527613|ref|ZP_07279955.1| uroporphyrin-III C-methyltransferase [Streptomyces sp. AA4] gi|302436508|gb|EFL08324.1| uroporphyrin-III C-methyltransferase [Streptomyces sp. AA4] Length=408 Score = 447 bits (1149), Expect = 2e-123, Method: Compositional matrix adjust. Identities = 237/398 (60%), Positives = 289/398 (73%), Gaps = 6/398 (1%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 YL GL L G++VVV GGG+VAQRRLP LI++GA V V++P TP+V+ M ++ R Sbjct 6 YLSGLNLTGRRVVVFGGGSVAQRRLPRLISAGARVEVVSPHTTPSVQGMADAGELVWHQR 65 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y +GDL AWYA+A T+D N A+ AEAER R+FCVRAD G+AVTPA+ + GL Sbjct 66 RYAEGDLREAWYALACTNDPEANAAICAEAERERVFCVRADEGESGSAVTPATGRHGGLL 125 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSG---GVALVGGGPGDPELITVRG 179 GVL+GGE RSAA+R ++ + L G I G GVALVGGGPGDP+LITVR Sbjct 126 FGVLSGGEPLRSAAVRDSMLDGLHAGTIEDGRQPHPEGTLPGVALVGGGPGDPDLITVRA 185 Query 180 RRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNF 239 RRLL++ADVVV DRL P +LL EL P VEVIDAAKIPYGRA +QD IN LIE+A+ G F Sbjct 186 RRLLSRADVVVVDRLGPRDLLDELAPEVEVIDAAKIPYGRAASQDVINRTLIEKAKEGKF 245 Query 240 VVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVV 299 VVRLKGGDP++F RG+EEV ACA AG+PVT+VPG+TSA AVPA+A VPVTHR + HE VV Sbjct 246 VVRLKGGDPYLFGRGFEEVQACAEAGVPVTMVPGITSAFAVPAVADVPVTHRGVAHEVVV 305 Query 300 VSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGT 359 VSGH+APG SLV+W LA + GTIVL+M VER+ F LL+GGR DTPV V++ GT Sbjct 306 VSGHVAPGDERSLVDWSLLARMRGTIVLMMGVERLPKFAAALLEGGRPGDTPVAVIEDGT 365 Query 360 TAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ LR+TLA E+ AAG+RPPA+IV G V GL Sbjct 366 MRTQRVLRSTLASVAEEAAAAGVRPPAVIVFGPVAGLD 403 >gi|302550201|ref|ZP_07302543.1| uroporphyrin-III methyltransferase [Streptomyces viridochromogenes DSM 40736] gi|302467819|gb|EFL30912.1| uroporphyrin-III methyltransferase [Streptomyces viridochromogenes DSM 40736] Length=413 Score = 446 bits (1147), Expect = 4e-123, Method: Compositional matrix adjust. Identities = 238/400 (60%), Positives = 295/400 (74%), Gaps = 8/400 (2%) Query 3 ENP-YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQIT 58 E+P Y VGLRL G++VVV+GGG VAQRRLP LIA+GAD+ +++P VTP+V+AM +IT Sbjct 3 EHPAYPVGLRLTGRRVVVLGGGQVAQRRLPALIAAGADILLVSPEVTPSVQAMADAGEIT 62 Query 59 LSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSY 118 R Y +GDL AWYA+ AT D N AEAERRR++CVR+D A E TA TPA+ Sbjct 63 WRRRPYEEGDLTDAWYALIATGDVDANTRASAEAERRRVWCVRSDDADEATAWTPATGHS 122 Query 119 AGLSVGVLA----GGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPEL 174 G++V VL G + R +AAIR A+ E L+ G + A + GVALVGGGPGDP+L Sbjct 123 EGVTVAVLTTDARGRDPRHTAAIRDAVVEGLRDGTLVAPHHRTRTPGVALVGGGPGDPDL 182 Query 175 ITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERA 234 ITVRGRRLLA+ADVV+ADRL P +LLAELPPHVEVIDAAKIPYGR MAQ+AIN LIE A Sbjct 183 ITVRGRRLLAEADVVIADRLGPRDLLAELPPHVEVIDAAKIPYGRFMAQEAINNALIEHA 242 Query 235 RSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMT 294 + G VVRLKGGDP+VF RG EE+ A A GIP TVVPG++S+I+VP+ G+PVTHR + Sbjct 243 KQGKSVVRLKGGDPYVFGRGMEELQALAEVGIPCTVVPGISSSISVPSAVGIPVTHRGVA 302 Query 295 HEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLV 354 HEF VVSGH+AP SLV+W +LA LTGT+V+LM V++I + L+ G+ ADTPV + Sbjct 303 HEFTVVSGHVAPDDERSLVDWPSLARLTGTLVILMGVDKIGRIAETLVAHGKPADTPVAL 362 Query 355 VQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVV 394 VQ GTTAAQ+ + ATLA E VR ++PPA+IVIG VV Sbjct 363 VQEGTTAAQRRVDATLATVAETVRTEDVKPPAVIVIGEVV 402 >gi|262202077|ref|YP_003273285.1| uroporphyrin-III C-methyltransferase [Gordonia bronchialis DSM 43247] gi|262085424|gb|ACY21392.1| uroporphyrin-III C-methyltransferase [Gordonia bronchialis DSM 43247] Length=413 Score = 444 bits (1143), Expect = 1e-122, Method: Compositional matrix adjust. Identities = 255/399 (64%), Positives = 305/399 (77%), Gaps = 0/399 (0%) Query 3 ENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVR 62 E YLVGL LAG+KVVVVGGG+VAQRRLP L++SGA VHVIA TPAVE+ + + R Sbjct 15 EGHYLVGLDLAGRKVVVVGGGSVAQRRLPNLVSSGAQVHVIAIDPTPAVESFAGVHVHQR 74 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y DGDLDGAWYA+A TDD VN AVVAEAERR FCVRAD A GTAVTPAS + + Sbjct 75 AYADGDLDGAWYAMACTDDPAVNAAVVAEAERRHTFCVRADDARFGTAVTPASGRHRDVR 134 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 GVLAGG+HR SAA+R+AI AL G +T + GVALVGGGPGDP+LITVRG+RL Sbjct 135 FGVLAGGDHRLSAALRAAISRALADGSLTVEDDTRRPAGVALVGGGPGDPDLITVRGQRL 194 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 LA ADVVVADRLAPPELLA L P VE+IDAAK+PYGRAM Q+AIN VL+ +AR G FVVR Sbjct 195 LADADVVVADRLAPPELLAALGPQVEIIDAAKVPYGRAMKQEAINDVLVAKAREGKFVVR 254 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDP+V+ RG+EE+ AC AG+PVTVVPG++S+IA PA AG+PVTHR +THE V+ SG Sbjct 255 LKGGDPYVYGRGFEELQACVAAGVPVTVVPGISSSIAAPASAGIPVTHRGVTHEVVIASG 314 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+ PGHP+SL++W ALA L GT+VL+MAVER+E+F D LL GGR TPV ++++G+ Sbjct 315 HVPPGHPDSLIDWAALAKLRGTLVLMMAVERVEVFADALLDGGRPPATPVAMIENGSLPT 374 Query 363 QQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRG 401 Q+ LR LA E G+RPPAI+VIG V G + G Sbjct 375 QRVLRTDLAHAGEVAAQEGLRPPAIVVIGEVAGFTDAAG 413 >gi|302541205|ref|ZP_07293547.1| uroporphyrinogen-III C-methyltransferase [Streptomyces hygroscopicus ATCC 53653] gi|302458823|gb|EFL21916.1| uroporphyrinogen-III C-methyltransferase [Streptomyces himastatinicus ATCC 53653] Length=413 Score = 443 bits (1140), Expect = 2e-122, Method: Compositional matrix adjust. Identities = 248/404 (62%), Positives = 301/404 (75%), Gaps = 4/404 (0%) Query 1 VTEN-PYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQ 56 ++EN Y VGLRL G++VVV+G G VAQRRLP LIA+GAD+ +I+PS TP+VEAM + Sbjct 9 MSENFAYPVGLRLTGRRVVVLGAGQVAQRRLPALIAAGADILLISPSATPSVEAMAEAGE 68 Query 57 ITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASF 116 + R YRDGD +GAWYA+ TDD N A AEAE RR++CVR+D A +A TPA+ Sbjct 69 VRWERRRYRDGDFEGAWYALITTDDPAANAAASAEAEARRVWCVRSDDAEAASAWTPATG 128 Query 117 SYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELIT 176 G++V VL G + RRSAA+R A+ E L+ G + A VALVGGGPGDP+LIT Sbjct 129 RSEGVTVAVLTGQDPRRSAAVRDAVVEGLRDGTLAAPRHRTRGPHVALVGGGPGDPDLIT 188 Query 177 VRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARS 236 VRGRRLLA+ADVVVADRL P +LL ELPPHVEVIDAAKIPYGR MAQ+AIN LIE A++ Sbjct 189 VRGRRLLAEADVVVADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINNALIEHAKA 248 Query 237 GNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHE 296 G VVRLKGGDPFVF RG EE A A AGIP TVVPG++S+I+VPA AG+PVTHR + HE Sbjct 249 GKSVVRLKGGDPFVFGRGMEEAEALAEAGIPCTVVPGISSSISVPASAGIPVTHRGVAHE 308 Query 297 FVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQ 356 F VVSGH+AP P SLV+W ALA+L GT+VLLMAVE+I L++ GR+ADTPV V+Q Sbjct 309 FTVVSGHVAPDDPRSLVDWSALASLRGTLVLLMAVEKIGAIAAALIQHGRSADTPVAVIQ 368 Query 357 HGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVR 400 GTTAAQ+ + ATLA + V A G+RPPA+IVIG VV + R Sbjct 369 EGTTAAQRRVDATLATVGDTVTAEGVRPPAVIVIGEVVAVGSRR 412 >gi|29833338|ref|NP_827972.1| uroporphyrin-III methyltransferase [Streptomyces avermitilis MA-4680] gi|29610461|dbj|BAC74507.1| putative uroporphyrin-III methyltransferase [Streptomyces avermitilis MA-4680] Length=410 Score = 442 bits (1137), Expect = 4e-122, Method: Compositional matrix adjust. Identities = 248/402 (62%), Positives = 297/402 (74%), Gaps = 8/402 (1%) Query 1 VTENP-YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQ 56 + E+P Y VGLRL G++VVV+GGG VAQRRLP LIA+GA VH+++P TP+VEAM + Sbjct 1 MAEHPAYPVGLRLTGRRVVVLGGGQVAQRRLPALIAAGAKVHLVSPEATPSVEAMADTGE 60 Query 57 ITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASF 116 IT S R Y DGDL AWYA+ AT DA NVA AEAER R++CVR+D A TA TPA+ Sbjct 61 ITWSRRRYEDGDLAEAWYALIATSDAAANVAASAEAERLRVWCVRSDDADAATAWTPATG 120 Query 117 SYAGLSVGVLA----GGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDP 172 G++V VL G + R +AAIR A+ E L+ G + A V + GVALVGGGPGDP Sbjct 121 HSEGVTVAVLTTNAKGRDPRHTAAIRDAVVEGLRDGTLVAPHHRVRTPGVALVGGGPGDP 180 Query 173 ELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIE 232 +LITVRGRRLLA+ADVV+ADRL P +LLAELPPHVEVIDAAKIPYGR MAQ+AIN LIE Sbjct 181 DLITVRGRRLLAEADVVIADRLGPRDLLAELPPHVEVIDAAKIPYGRFMAQEAINNALIE 240 Query 233 RARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRA 292 AR G VVRLKGGDPFVF RG EE A A GIP TVVPG++S+I+VP AG+PVTHR Sbjct 241 HARQGKSVVRLKGGDPFVFGRGMEEAQALAEVGIPCTVVPGISSSISVPGAAGIPVTHRG 300 Query 293 MTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPV 352 + HEF VVSGH+AP SLV+W ALA L GT+V+LM V++I D L+ G+ A TPV Sbjct 301 VAHEFTVVSGHVAPDDERSLVDWPALAKLRGTLVILMGVDKIGKIADTLVAHGKPAGTPV 360 Query 353 LVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVV 394 +VQ GTTAAQ+ + ATLA E VRA ++PPA+IVIGAVV Sbjct 361 ALVQEGTTAAQRRVDATLATVAETVRAQDVKPPAVIVIGAVV 402 >gi|302533438|ref|ZP_07285780.1| uroporphyrin-III methyltransferase [Streptomyces sp. C] gi|302442333|gb|EFL14149.1| uroporphyrin-III methyltransferase [Streptomyces sp. C] Length=407 Score = 441 bits (1135), Expect = 9e-122, Method: Compositional matrix adjust. Identities = 246/392 (63%), Positives = 300/392 (77%), Gaps = 5/392 (1%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 Y VGLRLAG++VVV+GGG VAQRRLP L+A+GADV +++PS TP+V+AM +I R Sbjct 9 YPVGLRLAGRRVVVIGGGQVAQRRLPALVAAGADVLLVSPSATPSVDAMAETGEIRWERR 68 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y+DGDLDGAWYA+ AT D N A AEAE RR++CVRAD A TA TPA+ G++ Sbjct 69 RYQDGDLDGAWYALIATRDRAANDAASAEAEARRVWCVRADDADAATAWTPATGRVEGVT 128 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 V VL+G + RRSAA+R A+ E L+ G +TA V GVALVGGGPGDP+LITVRGRRL Sbjct 129 VAVLSGNDPRRSAAVRDAVVEGLRDGSLTAARPRV--PGVALVGGGPGDPDLITVRGRRL 186 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 LA+ADVV+ADRL P +LL ELPPHVEVIDAAKIPYGR MAQ+AIN LIE A++G VVR Sbjct 187 LAEADVVIADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINNALIEHAKAGKAVVR 246 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDP+VF RG EE+ A A GI TVVPG++S+I+VP+ AG+PVTHR + HEF VVSG Sbjct 247 LKGGDPYVFGRGMEELQALAAEGIACTVVPGISSSISVPSAAGIPVTHRGVAHEFTVVSG 306 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+ P P SLV+W ALA LTGTIV+LM V++I L + L++ GR+ADTPV VVQ GTTA Sbjct 307 HVGPDDPRSLVDWAALAKLTGTIVILMGVDKIGLIAEALVRHGRSADTPVAVVQEGTTAT 366 Query 363 QQTLRATLADTPEKVRAAGIRPPAIIVIGAVV 394 Q+ + ATLA E V+A +RPPA+IVIG VV Sbjct 367 QRRVDATLATVGETVKAQEVRPPAVIVIGDVV 398 >gi|345010602|ref|YP_004812956.1| uroporphyrin-III C-methyltransferase [Streptomyces violaceusniger Tu 4113] gi|344036951|gb|AEM82676.1| uroporphyrin-III C-methyltransferase [Streptomyces violaceusniger Tu 4113] Length=406 Score = 441 bits (1134), Expect = 1e-121, Method: Compositional matrix adjust. Identities = 241/395 (62%), Positives = 289/395 (74%), Gaps = 3/395 (0%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 Y VGLRL+G++VVV+G G VAQRRLP LIA+GAD+ +I+PS T +VEAM ++ R Sbjct 7 YPVGLRLSGRRVVVLGAGQVAQRRLPALIAAGADILLISPSATASVEAMAEAGEVRWERR 66 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y++GD +GAWY + TDD N AEAE RRI+CVR+D A +A TPA+ G++ Sbjct 67 RYQEGDFEGAWYVLITTDDPEANATASAEAEARRIWCVRSDDAEAASAWTPATGRSEGVT 126 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 V VL G + RRSAA+R A+ E L+ G + A VALVGGGPGDP+LITVRGRRL Sbjct 127 VAVLTGQDPRRSAAVRDAVVEGLRDGTLAAPRHRSRGPRVALVGGGPGDPDLITVRGRRL 186 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 LA+ADVVVADRL P +LL ELPPHVEVIDAAKIPYGR MAQ+AIN LIE A++G VVR Sbjct 187 LAEADVVVADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINNALIEHAKAGKSVVR 246 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDPFVF RG EE A A AGIP TVVPG++S+I+VP AG+PVTHR + HEF VVSG Sbjct 247 LKGGDPFVFGRGMEEAEALAEAGIPCTVVPGISSSISVPGAAGIPVTHRGVAHEFTVVSG 306 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+AP P SLV+W ALA L GT+VLLMAVE+I L+ GR ADTPV VVQ GTT A Sbjct 307 HVAPDDPSSLVDWAALARLRGTLVLLMAVEKIGAIAATLVAHGRAADTPVAVVQEGTTPA 366 Query 363 QQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 Q+ + ATLA EK G+RPPA++VIG VV LS Sbjct 367 QRRVDATLATVGEKAATEGVRPPAVVVIGDVVALS 401 >gi|343926760|ref|ZP_08766257.1| siroheme synthase CysG [Gordonia alkanivorans NBRC 16433] gi|343763359|dbj|GAA13183.1| siroheme synthase CysG [Gordonia alkanivorans NBRC 16433] Length=403 Score = 438 bits (1127), Expect = 6e-121, Method: Compositional matrix adjust. Identities = 250/392 (64%), Positives = 309/392 (79%), Gaps = 0/392 (0%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVRDYR 65 YLVGL LAG++VVVVGGG+VAQRRLP LIA+GADVHVIA TPAVE+ IT++ R Y Sbjct 9 YLVGLDLAGRRVVVVGGGSVAQRRLPNLIAAGADVHVIAIDPTPAVESFQGITVTRRAYA 68 Query 66 DGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGV 125 DGDL+GAWYA+A TDD VN AVVAEAERR FCVRAD A GTAVTPAS + + GV Sbjct 69 DGDLEGAWYAMACTDDPAVNAAVVAEAERRHTFCVRADDAQYGTAVTPASARHRDVQFGV 128 Query 126 LAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRLLAQ 185 LAGG+H+ SAA+R+AI AL +G ++ + + GVALVGGGPGDP+LITVRG+RLLA+ Sbjct 129 LAGGDHKLSAALRAAISRALAEGSLSVDDVEPHAPGVALVGGGPGDPDLITVRGQRLLAE 188 Query 186 ADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLKG 245 ADVVVADRLAP ELL L P VE+IDAAK+PYGRAM Q+AIN VL+ RA+ G FVVRLKG Sbjct 189 ADVVVADRLAPAELLESLGPQVEIIDAAKVPYGRAMKQEAINDVLVARAKEGKFVVRLKG 248 Query 246 GDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSGHLA 305 GDP+V+ RG+EE+ AC AG+PVTVVPG++S+IA PA AG+PVTHR +THE V+ SGH+ Sbjct 249 GDPYVYGRGFEELQACVAAGVPVTVVPGISSSIAAPASAGIPVTHRGVTHEVVIASGHVP 308 Query 306 PGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAAQQT 365 PGHP+SL++W A+ L GT+VL+MAVER+++F D LL+GGR ADTPV ++++G+ Q+ Sbjct 309 PGHPDSLIDWSAMGKLRGTLVLMMAVERVDVFADALLEGGRPADTPVAMIENGSLPTQRL 368 Query 366 LRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 LR LA E A G+RPPAI+VIG V + Sbjct 369 LRTDLAHAAEVAEAEGLRPPAIVVIGQVAAFT 400 >gi|289751509|ref|ZP_06510887.1| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis T92] gi|289692096|gb|EFD59525.1| multifunctional siroheme synthase cysG [Mycobacterium tuberculosis T92] Length=226 Score = 437 bits (1124), Expect = 1e-120, Method: Compositional matrix adjust. Identities = 225/226 (99%), Positives = 226/226 (100%), Gaps = 0/226 (0%) Query 1 VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 +TENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS Sbjct 1 MTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLS 60 Query 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG Sbjct 61 VRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAG 120 Query 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR Sbjct 121 LSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGR 180 Query 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAI 226 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAI Sbjct 181 RLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAI 226 >gi|294811613|ref|ZP_06770256.1| Putative uroporphyrin-III methyltransferase [Streptomyces clavuligerus ATCC 27064] gi|326440199|ref|ZP_08214933.1| uroporphyrin-III methyltransferase [Streptomyces clavuligerus ATCC 27064] gi|294324212|gb|EFG05855.1| Putative uroporphyrin-III methyltransferase [Streptomyces clavuligerus ATCC 27064] Length=412 Score = 437 bits (1124), Expect = 2e-120, Method: Compositional matrix adjust. Identities = 245/400 (62%), Positives = 292/400 (73%), Gaps = 7/400 (1%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 Y VGLRLAG++VVV+GGG VAQRRLP L+A+GAD+ +++PS TP+VEAM +I R Sbjct 7 YPVGLRLAGRRVVVLGGGQVAQRRLPALLAAGADIVLVSPSATPSVEAMATSGEIHWERR 66 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y +GDL GAWYA+ AT D N AEAER R++CVRAD A TA TPA+ G++ Sbjct 67 RYAEGDLAGAWYALIATTDPEANTRASAEAERSRVWCVRADDAHAATAWTPATGRSEGVT 126 Query 123 VGVLA----GGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVR 178 V VL G + RRSAA+R AI E L+ G ++A GVALVGGGPGDP+LITVR Sbjct 127 VAVLTTEPEGRDPRRSAALRDAIVEGLRDGTLSAPQHRTRVPGVALVGGGPGDPDLITVR 186 Query 179 GRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGN 238 GRRLLA+ADVVVADRL P +LLAELPPHVEVIDAAKIPYGR MAQ+AINA LIE AR+G Sbjct 187 GRRLLAEADVVVADRLGPRDLLAELPPHVEVIDAAKIPYGRFMAQEAINAALIEHARAGR 246 Query 239 FVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFV 298 VVRLKGGDPFVF RG EE A A AGIP TVVPG++S+I+VP G+PVTHR + HEF Sbjct 247 AVVRLKGGDPFVFGRGMEEAEALAEAGIPCTVVPGISSSISVPGAVGIPVTHRGVAHEFA 306 Query 299 VVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHG 358 VVSGH+AP SLV+W ALA L GT+V+LM V++I L+ GR TPV ++Q G Sbjct 307 VVSGHVAPDDDRSLVDWPALARLRGTLVVLMGVDKIGAIAQTLVANGREPHTPVALIQEG 366 Query 359 TTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSG 398 TTAAQ+ + ATLA + V A GIRPPA+IVIG VV L G Sbjct 367 TTAAQRRVDATLATVADTVVAEGIRPPAVIVIGEVVALGG 406 >gi|302561651|ref|ZP_07313993.1| uroporphyrinogen-III C-methyltransferase [Streptomyces griseoflavus Tu4000] gi|302479269|gb|EFL42362.1| uroporphyrinogen-III C-methyltransferase [Streptomyces griseoflavus Tu4000] Length=410 Score = 436 bits (1121), Expect = 3e-120, Method: Compositional matrix adjust. Identities = 233/392 (60%), Positives = 287/392 (74%), Gaps = 8/392 (2%) Query 3 ENP-YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQIT 58 ENP Y VGLRL G++VVV+GGG VAQRRLP LIA+GAD+H+++P TP+VEAM +IT Sbjct 3 ENPAYPVGLRLTGRRVVVLGGGQVAQRRLPALIAAGADIHLVSPEATPSVEAMAEAGEIT 62 Query 59 LSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSY 118 R Y +GDL AWYA+ AT D N AEAE R++CVR+D A TA TPA+ S Sbjct 63 WHRRGYTEGDLATAWYALIATSDTDANTRASAEAEAHRVWCVRSDDADAATAWTPATGSS 122 Query 119 AGLSVGVLA----GGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPEL 174 G++V VL G + R +AAIR A+ E L+ G + A + GVALVGGGPGDP+L Sbjct 123 EGVTVAVLTTEARGRDPRHTAAIRDAVVEGLRDGTLVAPHHRTRTPGVALVGGGPGDPDL 182 Query 175 ITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERA 234 ITVRGRRLLA+ADVV+ADRL P +LLAELPPHVEVIDAAKIPYGR MAQ+AIN LIE A Sbjct 183 ITVRGRRLLAEADVVIADRLGPRDLLAELPPHVEVIDAAKIPYGRFMAQEAINDALIEHA 242 Query 235 RSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMT 294 + G VVRLKGGDP+VF RG EE+ A A AGIP TVVPG++S+I+VP AG+PVTHR + Sbjct 243 QRGKSVVRLKGGDPYVFGRGMEELQALAEAGIPCTVVPGISSSISVPGAAGIPVTHRGVA 302 Query 295 HEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLV 354 HEF VVSGH+AP SLV+W +LA LTGT+V+LM V++I + L+ G++ DTPV + Sbjct 303 HEFTVVSGHVAPDDERSLVDWPSLAKLTGTLVVLMGVDKIGRIAETLVANGKSPDTPVAL 362 Query 355 VQHGTTAAQQTLRATLADTPEKVRAAGIRPPA 386 VQ GTTAAQ+ + ATLA E V A ++PPA Sbjct 363 VQEGTTAAQRRVDATLATVAETVVAQDVKPPA 394 >gi|291440727|ref|ZP_06580117.1| uroporphyrin-III methyltransferase [Streptomyces ghanaensis ATCC 14672] gi|291343622|gb|EFE70578.1| uroporphyrin-III methyltransferase [Streptomyces ghanaensis ATCC 14672] Length=410 Score = 436 bits (1120), Expect = 4e-120, Method: Compositional matrix adjust. Identities = 235/394 (60%), Positives = 288/394 (74%), Gaps = 8/394 (2%) Query 1 VTENP-YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQ 56 + E+P Y VGLRL G++VVV+GGG VAQRRLP LIA+GAD+ +I+P TP+VEAM + Sbjct 1 MAEHPAYPVGLRLTGRRVVVLGGGQVAQRRLPALIAAGADLLLISPEATPSVEAMADTGE 60 Query 57 ITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASF 116 IT R Y +GDL GAWYA+ AT D N AEAER R++CVR+D A TA TPA+ Sbjct 61 ITWERRGYTEGDLAGAWYALIATSDPDANERASAEAERNRVWCVRSDDADRATAWTPATG 120 Query 117 SYAGLSVGVLA----GGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDP 172 G++V VL G + R +AA+R A+ E L+ G + A + GVALVGGGPGDP Sbjct 121 HSEGVTVAVLTTDAKGRDPRHTAAVRDAVVEGLRDGTLVAPHHRTRTPGVALVGGGPGDP 180 Query 173 ELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIE 232 +LITVRGRRLLA+ADVV+ADRL P +LLAELPPHVEVIDAAKIPYGR MAQ+AIN LIE Sbjct 181 DLITVRGRRLLAEADVVIADRLGPRDLLAELPPHVEVIDAAKIPYGRFMAQEAINNALIE 240 Query 233 RARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRA 292 AR G VVRLKGGDP+VF RG EE+ A A AG+P TVVPG++S+I+VP AG+PVTHR Sbjct 241 HARQGKSVVRLKGGDPYVFGRGMEELQALAEAGVPCTVVPGISSSISVPGAAGIPVTHRG 300 Query 293 MTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPV 352 + HEF VVSGH+AP SLV+W ALA LTGT+V+LM V++I + L+ GR+ DTPV Sbjct 301 VAHEFTVVSGHVAPDDERSLVDWPALAKLTGTLVVLMGVDKIGRIAETLMAHGRSPDTPV 360 Query 353 LVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPA 386 +VQ GTTAAQ+ + ATLA E V A +RPPA Sbjct 361 ALVQEGTTAAQRRVDATLATVAETVVAREVRPPA 394 >gi|326382930|ref|ZP_08204620.1| uroporphyrin-III C-methyltransferase [Gordonia neofelifaecis NRRL B-59395] gi|326198520|gb|EGD55704.1| uroporphyrin-III C-methyltransferase [Gordonia neofelifaecis NRRL B-59395] Length=405 Score = 436 bits (1120), Expect = 4e-120, Method: Compositional matrix adjust. Identities = 246/393 (63%), Positives = 299/393 (77%), Gaps = 1/393 (0%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVRDYR 65 YL GL L G+KVVVVGGG+VAQRRLP L+A+GADVHV+A TPAVE+ IT+ R Y Sbjct 5 YLAGLDLHGRKVVVVGGGSVAQRRLPNLVAAGADVHVVAVDPTPAVESEVAITVHRRAYA 64 Query 66 DGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGV 125 DGDLDGAWYA+A TDD VN AVVAEAERRR+FCVRAD A +GTAVTPA+ + L GV Sbjct 65 DGDLDGAWYAMACTDDPAVNAAVVAEAERRRVFCVRADDARQGTAVTPATGVHRDLHFGV 124 Query 126 LAGGEHRRSAAIRSAIREALQQGVITAQSSDVL-SGGVALVGGGPGDPELITVRGRRLLA 184 LA G+HRRSAA+R+AI EAL G + D + GVALVGGGPGD +LITVRGR+LLA Sbjct 125 LAAGDHRRSAAVRAAITEALADGTSLRITDDRRHAAGVALVGGGPGDADLITVRGRKLLA 184 Query 185 QADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLK 244 +ADVVVADRLAP LL EL P VEVIDAAK+PYGRAM Q+ IN +L++RA++G FVVRLK Sbjct 185 EADVVVADRLAPIALLDELGPQVEVIDAAKVPYGRAMRQEQINEILVDRAKAGKFVVRLK 244 Query 245 GGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSGHL 304 GGDP+V+ RG+EE+ AC AG+PVTVVPG++S IA P +AG+PVTHR +THE V+VSGH+ Sbjct 245 GGDPYVYGRGFEELQACVAAGVPVTVVPGISSPIAGPELAGIPVTHRGVTHEVVIVSGHV 304 Query 305 APGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAAQQ 364 AP HP+SL NW ALA + GT+VL+MAV+RI+ F LL GGR ADTPV +++ + Q+ Sbjct 305 APDHPDSLTNWQALAQMRGTVVLMMAVKRIDEFATALLDGGRAADTPVAFIENASRPDQR 364 Query 365 TLRATLADTPEKVRAAGIRPPAIIVIGAVVGLS 397 LR LA + + PAI VIG V G + Sbjct 365 LLRTDLAHAAQTAVEQELIAPAIAVIGPVAGFT 397 >gi|337769247|emb|CCB77960.1| putative uroporphyrin-III methyltransferase [Streptomyces cattleya NRRL 8057] Length=407 Score = 434 bits (1116), Expect = 1e-119, Method: Compositional matrix adjust. Identities = 252/398 (64%), Positives = 296/398 (75%), Gaps = 3/398 (0%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 Y VGLRLAG++VVV+GGG VAQRRLP L+A+GADV +++PS TPAVEAM ++ R Sbjct 9 YPVGLRLAGRRVVVLGGGQVAQRRLPGLVAAGADVLLVSPSATPAVEAMADAGEVRWERR 68 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y GDL GAWYA+ ATDDA N A AEAE RR++CVR+D A TA TPA+ G++ Sbjct 69 RYTPGDLAGAWYAVVATDDAAANAAASAEAEERRVWCVRSDDAEAATAWTPATGRDEGVT 128 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 V VL G + RRSAA+R A+ E L+ G + A + GVALVGGGPGDP+LITVRGRRL Sbjct 129 VAVLTGRDPRRSAAVRDAVVEGLRDGTLVAPRHRARTPGVALVGGGPGDPDLITVRGRRL 188 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 LA+ADVVVADRL P +LL ELPPHVEVIDAAKIPYGRAMAQ+AIN LI+ AR+G VVR Sbjct 189 LAEADVVVADRLGPRDLLDELPPHVEVIDAAKIPYGRAMAQEAINDALIQHARAGKAVVR 248 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDPFVF RG EEV A A AGI TVVPG++S+I+VP AG+PVTHR + HEF VVSG Sbjct 249 LKGGDPFVFGRGMEEVQALAEAGIACTVVPGISSSISVPGAAGIPVTHRGVAHEFTVVSG 308 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+AP P SLV+W ALA L GT+VLLMAVERI L++ GR TPV VVQ GTTAA Sbjct 309 HVAPEDPRSLVDWAALARLRGTLVLLMAVERIGAIARALVEHGRDPQTPVAVVQEGTTAA 368 Query 363 QQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVR 400 Q+ + ATLA V A G+RPPA+IVIG VV L R Sbjct 369 QRRVDATLATVGATVAAEGVRPPAVIVIGDVVALEAGR 406 >gi|328881200|emb|CCA54439.1| Siroheme synthase or Precorrin-2 oxidase or Sirohydrochlorin ferrochelatase or Uroporphyrinogen-III methyltransferase [Streptomyces venezuelae ATCC 10712] Length=453 Score = 431 bits (1107), Expect = 1e-118, Method: Compositional matrix adjust. Identities = 238/392 (61%), Positives = 288/392 (74%), Gaps = 3/392 (0%) Query 6 YLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVR 62 Y VGLRLAG++VVV+GGG VAQRRLP LIA+GAD+ +I+PS TP+VEAM +IT R Sbjct 51 YPVGLRLAGRRVVVLGGGQVAQRRLPALIAAGADITLISPSATPSVEAMAEAGEITWVKR 110 Query 63 DYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLS 122 Y DGDL AWYA+ AT D N A AEAER R +CVR+D A TA TPA+ G++ Sbjct 111 RYEDGDLADAWYALVATTDPASNAAASAEAERTRTWCVRSDDAEAATAWTPATGRGEGVT 170 Query 123 VGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRL 182 V VL G + RRSAA+R AI E L+ G I A + VALVGGGPGDP+LITVRGRRL Sbjct 171 VAVLTGHDPRRSAAVRDAILEGLRDGSIAAPQHRARTPFVALVGGGPGDPDLITVRGRRL 230 Query 183 LAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVR 242 LA+ADVV+ADRL P +LL ELPPHVEVIDAAKIPYGR MAQ+AIN LIE A++G VVR Sbjct 231 LAEADVVIADRLGPRDLLDELPPHVEVIDAAKIPYGRFMAQEAINNALIEHAKAGRSVVR 290 Query 243 LKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSG 302 LKGGDPFVF RG EE A A GI TVVPG++S+I+VP AG+PVTHR + HEF VVSG Sbjct 291 LKGGDPFVFGRGMEEAQALAAEGIACTVVPGISSSISVPGAAGIPVTHRGVAHEFTVVSG 350 Query 303 HLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAA 362 H+AP P SLV+W +LA LTGT+V+LM V++I + L+ G+ TP+ +VQ GTTA+ Sbjct 351 HVAPDDPRSLVDWASLAKLTGTLVILMGVDKIGKIAEALVAHGKDPRTPLALVQEGTTAS 410 Query 363 QQTLRATLADTPEKVRAAGIRPPAIIVIGAVV 394 Q+ + ATL E V+A +RPPA+IVIG VV Sbjct 411 QRRVDATLETVAETVKAQEVRPPAVIVIGDVV 442 Lambda K H 0.320 0.136 0.388 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 804061019016 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40