BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2848c Length=457 Score E Sequences producing significant alignments: (Bits) Value gi|15609985|ref|NP_217364.1| cobyrinic acid a,c-diamide synthase... 899 0.0 gi|254551912|ref|ZP_05142359.1| cobyrinic acid a,c-diamide synth... 899 0.0 gi|340627841|ref|YP_004746293.1| putative cobyrinic acid A,C-dia... 897 0.0 gi|294994062|ref|ZP_06799753.1| cobyrinic acid a,c-diamide synth... 866 0.0 gi|326904461|gb|EGE51394.1| LOW QUALITY PROTEIN: cobyrinic acid ... 866 0.0 gi|339295689|gb|AEJ47800.1| cobyrinic acid a,c-diamide synthase ... 865 0.0 gi|289746646|ref|ZP_06506024.1| cobyrinic acid a,c-diamide synth... 863 0.0 gi|183981898|ref|YP_001850189.1| cobyrinic acid a,C-diamide synt... 711 0.0 gi|118617673|ref|YP_906005.1| cobyrinic acid a,c-diamide synthas... 709 0.0 gi|240172751|ref|ZP_04751410.1| cobyrinic acid a,c-diamide synth... 706 0.0 gi|296171568|ref|ZP_06852832.1| cobyrinic Acid a,c-diamide synth... 689 0.0 gi|289758968|ref|ZP_06518346.1| cobyrinic acid a,c-diamide synth... 684 0.0 gi|342858320|ref|ZP_08714975.1| cobyrinic acid a,c-diamide synth... 673 0.0 gi|254776134|ref|ZP_05217650.1| cobyrinic acid a,c-diamide synth... 651 0.0 gi|118462227|ref|YP_882881.1| cobyrinic acid a,c-diamide synthas... 648 0.0 gi|41409015|ref|NP_961851.1| cobyrinic acid a,c-diamide synthase... 644 0.0 gi|336458987|gb|EGO37939.1| cobyrinic acid a,c-diamide synthase ... 642 0.0 gi|118468399|ref|YP_886954.1| cobyrinic acid a,c-diamide synthas... 631 7e-179 gi|119868155|ref|YP_938107.1| cobyrinic acid a,c-diamide synthas... 627 1e-177 gi|108799040|ref|YP_639237.1| cobyrinic acid a,c-diamide synthas... 626 3e-177 gi|120403295|ref|YP_953124.1| cobyrinic acid a,c-diamide synthas... 612 3e-173 gi|145224628|ref|YP_001135306.1| cobyrinic acid a,c-diamide synt... 610 1e-172 gi|315444960|ref|YP_004077839.1| hydrogenobyrinic acid a,c-diami... 605 6e-171 gi|226366060|ref|YP_002783843.1| cobyrinic acid a,c-diamide synt... 539 3e-151 gi|111023575|ref|YP_706547.1| cobyrinic acid a,c-diamide synthas... 536 3e-150 gi|325673404|ref|ZP_08153095.1| cobyrinic Acid a,c-diamide synth... 534 1e-149 gi|312139290|ref|YP_004006626.1| cobyrinate-a,c-diamine synthase... 532 6e-149 gi|226306095|ref|YP_002766055.1| cobyrinic acid a,c-diamide synt... 521 8e-146 gi|229491361|ref|ZP_04385185.1| cobyrinic Acid a,c-diamide synth... 516 2e-144 gi|54026052|ref|YP_120294.1| cobyrinic acid a,c-diamide synthase... 513 3e-143 gi|169630237|ref|YP_001703886.1| cobyrinic acid A,C-diamide synt... 501 1e-139 gi|256379854|ref|YP_003103514.1| cobyrinic acid a,c-diamide synt... 490 2e-136 gi|134102409|ref|YP_001108070.1| cobyrinic acid a,c-diamide synt... 489 3e-136 gi|333919279|ref|YP_004492860.1| Cobyrinic acid a,c-diamide synt... 480 2e-133 gi|262202070|ref|YP_003273278.1| cobyrinic acid a,c-diamide synt... 479 4e-133 gi|296139416|ref|YP_003646659.1| cobyrinic acid a,c-diamide synt... 478 1e-132 gi|326382926|ref|ZP_08204616.1| cobyrinic acid a,c-diamide synth... 477 2e-132 gi|343926755|ref|ZP_08766252.1| cobyrinic acid A,C-diamide synth... 474 9e-132 gi|334697120|gb|AEG81917.1| Cobyrinic acid a,c-diamide synthase ... 457 2e-126 gi|213964519|ref|ZP_03392719.1| cobyrinic Acid a,c-diamide synth... 455 7e-126 gi|337291006|ref|YP_004630027.1| Cobyrinic acid a,c-diamide synt... 454 1e-125 gi|325001453|ref|ZP_08122565.1| cobyrinic acid a,c-diamide synth... 447 2e-123 gi|300858709|ref|YP_003783692.1| cobyrinic acid a,c-diamide synt... 445 1e-122 gi|239986817|ref|ZP_04707481.1| cobyrinic acid a,c-diamide synth... 443 3e-122 gi|291443768|ref|ZP_06583158.1| cobyrinic acid a,c-diamide synth... 441 9e-122 gi|326780098|ref|ZP_08239363.1| Cobyrinic acid A,C-diamide synth... 440 3e-121 gi|182439434|ref|YP_001827153.1| cobyrinic acid a,c-diamide synt... 439 4e-121 gi|289772428|ref|ZP_06531806.1| cobyrinic acid a,c-diamide synth... 437 2e-120 gi|21220341|ref|NP_626120.1| cobyrinic acid a,c-diamide synthase... 437 2e-120 gi|161598673|ref|NP_939836.2| cobyrinic acid a,c-diamide synthas... 435 8e-120 >gi|15609985|ref|NP_217364.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis H37Rv] gi|15842389|ref|NP_337426.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis CDC1551] gi|31794025|ref|NP_856518.1| cobyrinic acid a,c-diamide synthase [Mycobacterium bovis AF2122/97] 68 more sequence titles Length=457 Score = 899 bits (2324), Expect = 0.0, Method: Compositional matrix adjust. Identities = 457/457 (100%), Positives = 457/457 (100%), Gaps = 0/457 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA Sbjct 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 Query 421 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA 457 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA Sbjct 421 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA 457 >gi|254551912|ref|ZP_05142359.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] gi|297635461|ref|ZP_06953241.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis KZN 4207] gi|297732460|ref|ZP_06961578.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis KZN R506] gi|313659792|ref|ZP_07816672.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis KZN V2475] Length=459 Score = 899 bits (2323), Expect = 0.0, Method: Compositional matrix adjust. Identities = 457/457 (100%), Positives = 457/457 (100%), Gaps = 0/457 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 3 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 62 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 63 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 122 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 123 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 182 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 183 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 242 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 243 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 302 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA Sbjct 303 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 362 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 363 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 422 Query 421 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA 457 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA Sbjct 423 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA 459 >gi|340627841|ref|YP_004746293.1| putative cobyrinic acid A,C-diamide synthase COBB [Mycobacterium canettii CIPT 140010059] gi|340006031|emb|CCC45201.1| putative cobyrinic acid A,C-diamide synthase COBB [Mycobacterium canettii CIPT 140010059] Length=457 Score = 897 bits (2317), Expect = 0.0, Method: Compositional matrix adjust. Identities = 455/457 (99%), Positives = 456/457 (99%), Gaps = 0/457 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGV+AGSA Sbjct 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVLAGSA 360 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDS LYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 361 RFTQHLKLGYRDAVAVVDSVLYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 Query 421 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA 457 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA Sbjct 421 GAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA 457 >gi|294994062|ref|ZP_06799753.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis 210] Length=553 Score = 866 bits (2237), Expect = 0.0, Method: Compositional matrix adjust. Identities = 440/440 (100%), Positives = 440/440 (100%), Gaps = 0/440 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 3 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 62 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 63 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 122 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 123 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 182 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 183 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 242 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 243 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 302 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA Sbjct 303 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 362 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 363 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 422 Query 421 GAVHSGVHASYLHTHPAATP 440 GAVHSGVHASYLHTHPAATP Sbjct 423 GAVHSGVHASYLHTHPAATP 442 >gi|326904461|gb|EGE51394.1| LOW QUALITY PROTEIN: cobyrinic acid a,c-diamide synthase cobB [Mycobacterium tuberculosis W-148] Length=458 Score = 866 bits (2237), Expect = 0.0, Method: Compositional matrix adjust. Identities = 440/440 (100%), Positives = 440/440 (100%), Gaps = 0/440 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA Sbjct 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 Query 421 GAVHSGVHASYLHTHPAATP 440 GAVHSGVHASYLHTHPAATP Sbjct 421 GAVHSGVHASYLHTHPAATP 440 >gi|339295689|gb|AEJ47800.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis CCDC5079] gi|339299304|gb|AEJ51414.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis CCDC5180] Length=613 Score = 865 bits (2234), Expect = 0.0, Method: Compositional matrix adjust. Identities = 440/440 (100%), Positives = 440/440 (100%), Gaps = 0/440 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 2 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 61 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 62 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 121 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 122 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 181 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 182 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 241 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 242 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 301 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA Sbjct 302 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 361 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 362 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 421 Query 421 GAVHSGVHASYLHTHPAATP 440 GAVHSGVHASYLHTHPAATP Sbjct 422 GAVHSGVHASYLHTHPAATP 441 >gi|289746646|ref|ZP_06506024.1| cobyrinic acid a,c-diamide synthase cobB [Mycobacterium tuberculosis 02_1987] gi|289687174|gb|EFD54662.1| cobyrinic acid a,c-diamide synthase cobB [Mycobacterium tuberculosis 02_1987] Length=578 Score = 863 bits (2229), Expect = 0.0, Method: Compositional matrix adjust. Identities = 440/440 (100%), Positives = 440/440 (100%), Gaps = 0/440 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 3 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 62 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 63 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 122 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 123 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 182 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 183 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 242 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 243 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 302 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA Sbjct 303 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 362 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD Sbjct 363 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 422 Query 421 GAVHSGVHASYLHTHPAATP 440 GAVHSGVHASYLHTHPAATP Sbjct 423 GAVHSGVHASYLHTHPAATP 442 >gi|183981898|ref|YP_001850189.1| cobyrinic acid a,C-diamide synthase CobB [Mycobacterium marinum M] gi|183175224|gb|ACC40334.1| cobyrinic acid a,C-diamide synthase CobB [Mycobacterium marinum M] Length=458 Score = 711 bits (1834), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/449 (80%), Positives = 392/449 (88%), Gaps = 0/449 (0%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 + V +AAPASGSGKTT+ATGLIGALRQAG VAPFKVGPDFIDPGYHALAAGRPGRNLD Sbjct 4 IPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDFIDPGYHALAAGRPGRNLD 63 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 PVLVGERLIGPLYAHG GADIAV+EGV+GLFDGRI A PA GS+AHVA LLG PVI Sbjct 64 PVLVGERLIGPLYAHGAQGADIAVVEGVMGLFDGRIEHAVAGPATGSSAHVANLLGTPVI 123 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDARGQSHS+AALLHGFSTFD+ TRIAGVILNRVGSARHE VLRQAC+QAGV V+GAI Sbjct 124 LVVDARGQSHSIAALLHGFSTFDSKTRIAGVILNRVGSARHEHVLRQACEQAGVPVVGAI 183 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP 242 PR+AELELPTRYLGLVTAVEYGRRARLAV+AMTA++ARHVD+ AV+A AGS PWDP Sbjct 184 PRSAELELPTRYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP 243 Query 243 VIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLP 302 V A+G AT+A+AAG+AF+F YAEHAE+LRAAGA+VVEFDPL E LP + V+LP Sbjct 244 VTAIGGAPAGHATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLGEPLPADSTGVLLP 303 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPEQFTAELSAND VRRQI +LA AGAP+HAECAGL+YL SELDG+PMC V+AGSARF Sbjct 304 GGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAGLIYLASELDGYPMCDVLAGSARF 363 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGA 422 T HL LGYRDAVAV DSALY+ G RVVGHEFHRT VTF+D Y+PAWVY+G D VRDG Sbjct 364 TPHLTLGYRDAVAVADSALYAAGHRVVGHEFHRTTVTFSDRYEPAWVYRGNDAAAVRDGV 423 Query 423 VHSGVHASYLHTHPAATPGAVARFVAHAA 451 VH+GVHASYLHTHPA+TP AVARFVAHAA Sbjct 424 VHAGVHASYLHTHPASTPDAVARFVAHAA 452 >gi|118617673|ref|YP_906005.1| cobyrinic acid a,c-diamide synthase [Mycobacterium ulcerans Agy99] gi|118569783|gb|ABL04534.1| cobyrinic acid a,C-diamide synthase CobB [Mycobacterium ulcerans Agy99] Length=458 Score = 709 bits (1829), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/449 (80%), Positives = 391/449 (88%), Gaps = 0/449 (0%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 + V +AAPASGSGKTT+ATGLIGALRQAG VAPFKVGPDFIDPGYHALAAGRPGRNLD Sbjct 4 IPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDFIDPGYHALAAGRPGRNLD 63 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 PVLVGERLIGPLYAHG GADIAV+EGV+GLFDGRI A PA GS+AHVA LLG PVI Sbjct 64 PVLVGERLIGPLYAHGAQGADIAVVEGVMGLFDGRIEHAVAGPATGSSAHVANLLGTPVI 123 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDARGQSHS+AALLHGFSTFD+ TRIAGVILNRVGSARHE VLRQAC+QAGV V+GAI Sbjct 124 LVVDARGQSHSIAALLHGFSTFDSKTRIAGVILNRVGSARHEHVLRQACEQAGVPVVGAI 183 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP 242 PR+AELELPTRYLGLVTAVEYGRRARLAV+AMTA++ARHVD+ AV+A AGS PWDP Sbjct 184 PRSAELELPTRYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP 243 Query 243 VIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLP 302 V A+G AT+A+AAG+AF+F YAEHAE+LRAAGA+VVEFDPL E LP + V+LP Sbjct 244 VTAIGGAPAGHATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLGEPLPADSTGVLLP 303 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPEQFTAELSAND VRRQI +LA AGAP+HAECAGL+YL SELDG+PMC V+AGSARF Sbjct 304 GGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAGLIYLASELDGYPMCDVLAGSARF 363 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGA 422 T HL LGYRDAVAV DSALY+ G RVVGHEFHRT VTF+D Y+PAWVY+G D VRDG Sbjct 364 TPHLTLGYRDAVAVADSALYAAGHRVVGHEFHRTTVTFSDRYEPAWVYRGNDAAAVRDGV 423 Query 423 VHSGVHASYLHTHPAATPGAVARFVAHAA 451 VH+GVH SYLHTHPA+TP AVARFVAHAA Sbjct 424 VHAGVHVSYLHTHPASTPDAVARFVAHAA 452 >gi|240172751|ref|ZP_04751410.1| cobyrinic acid a,c-diamide synthase [Mycobacterium kansasii ATCC 12478] Length=457 Score = 706 bits (1823), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/452 (79%), Positives = 395/452 (88%), Gaps = 2/452 (0%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 A+ +AAPASGSGKTT+ATGL+GAL Q GH VAPFKVGPDFIDPGYH LA+ R GRNLDPV Sbjct 6 ALVIAAPASGSGKTTVATGLMGALCQGGHRVAPFKVGPDFIDPGYHTLASRRVGRNLDPV 65 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILV 124 LVGE+LIGPLYAHG GADIAVIEGV+GLFDGRI A PAAGSTAHVA LLGAPV+LV Sbjct 66 LVGEQLIGPLYAHGTVGADIAVIEGVMGLFDGRIDEAVSGPAAGSTAHVAGLLGAPVVLV 125 Query 125 VDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPR 184 VDARGQSHSVAALLHGF+TFD+ATRIAGVILNRVG+ARHE VLRQAC+QAGV VLGAIPR Sbjct 126 VDARGQSHSVAALLHGFTTFDSATRIAGVILNRVGTARHEHVLRQACEQAGVPVLGAIPR 185 Query 185 TAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVI 244 TAELELPTRYLGLVTAVEYGRRARLAV+AMTA+VARH+DL+A++A A S+ PPWDPV Sbjct 186 TAELELPTRYLGLVTAVEYGRRARLAVEAMTALVARHIDLSAIVAAAASRVGAPPWDPVT 245 Query 245 AVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGG 304 AVG TVA+AAG+AF+F YAEHAE+LRA GA+VVEFDPL++ LPEGT+AV+LPGG Sbjct 246 AVGGPVGGRPTVAMAAGKAFSFAYAEHAELLRAVGADVVEFDPLTQALPEGTNAVLLPGG 305 Query 305 FPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQ 364 FPEQF AELSAN+ VR Q+ +AAAG PVHAECAGL+YLVSELDG+PMCGV+AGSARFTQ Sbjct 306 FPEQFAAELSANELVRGQLQHMAAAGVPVHAECAGLIYLVSELDGYPMCGVLAGSARFTQ 365 Query 365 HLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDD--VRDGA 422 L LGYRDAVAV DS LYSVG RV GHEFHRT VTF DSYQPAWVY+ + DD +RDG Sbjct 366 RLTLGYRDAVAVADSPLYSVGRRVAGHEFHRTTVTFTDSYQPAWVYRSRGHDDHPLRDGV 425 Query 423 VHSGVHASYLHTHPAATPGAVARFVAHAACNT 454 VH GVHASYLHTHPAATP AVARFVAHA+ + Sbjct 426 VHGGVHASYLHTHPAATPEAVARFVAHASARS 457 >gi|296171568|ref|ZP_06852832.1| cobyrinic Acid a,c-diamide synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894130|gb|EFG73891.1| cobyrinic Acid a,c-diamide synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=452 Score = 689 bits (1777), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/439 (82%), Positives = 387/439 (89%), Gaps = 1/439 (0%) Query 14 GSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIGP 73 GSGKTT+ATGLIGALR+AGH VAPFKVGPDFIDPGYH LAAGRPGRNLDPVLVGE L+GP Sbjct 15 GSGKTTVATGLIGALRRAGHAVAPFKVGPDFIDPGYHGLAAGRPGRNLDPVLVGEELVGP 74 Query 74 LYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHS 133 LYAHG AGADIAVIEGV+GLFDGRIG A PA GSTAHVA LLGAPVILVVDARGQSHS Sbjct 75 LYAHGAAGADIAVIEGVMGLFDGRIGSAVAGPAEGSTAHVAGLLGAPVILVVDARGQSHS 134 Query 134 VAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPTR 193 +AALLHGFSTFD ATR+ GVILNRVGSARHE LRQAC+QAGVAVLGAIPR AELELPTR Sbjct 135 IAALLHGFSTFDAATRVRGVILNRVGSARHEHALRQACEQAGVAVLGAIPRRAELELPTR 194 Query 194 YLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTARQP 253 YLGLVTAVEYGRRAR AV+AMT +VA HVDL AV A A S+ P WDP AVG TA Sbjct 195 YLGLVTAVEYGRRARAAVEAMTDLVAGHVDLPAVAAVAASRPG-PVWDPATAVGETAGGR 253 Query 254 ATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQFTAEL 313 ATVA+AAG+AF+F YAEH E+LRAAGA+VVEFDPL++ LP+GTDAV+LPGGFPEQFTAEL Sbjct 254 ATVAMAAGKAFSFAYAEHVELLRAAGADVVEFDPLADQLPDGTDAVLLPGGFPEQFTAEL 313 Query 314 SANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDA 373 SAND VRRQ+NELAAAGAP+HAECAGL+YL +ELDGHPMCGV+AGSARFT HL L YRDA Sbjct 314 SANDIVRRQLNELAAAGAPIHAECAGLIYLATELDGHPMCGVLAGSARFTPHLTLAYRDA 373 Query 374 VAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHASYLH 433 VAV DS LYS G+R VGHEFHRTAVTF++SYQPAWVY+G + D VRDG V +GVHASYLH Sbjct 374 VAVADSPLYSAGQRAVGHEFHRTAVTFSESYQPAWVYRGNEADPVRDGVVRAGVHASYLH 433 Query 434 THPAATPGAVARFVAHAAC 452 THPAA P AVARFVAHAA Sbjct 434 THPAAAPRAVARFVAHAAS 452 >gi|289758968|ref|ZP_06518346.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis T85] gi|289714532|gb|EFD78544.1| cobyrinic acid a,c-diamide synthase [Mycobacterium tuberculosis T85] Length=400 Score = 684 bits (1765), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/396 (96%), Positives = 382/396 (97%), Gaps = 2/396 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 3 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 62 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP Sbjct 63 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 122 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG Sbjct 123 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 182 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW Sbjct 183 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 242 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV Sbjct 243 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 302 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMC V Sbjct 303 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMC-VCGRIG 361 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRT 396 FTQHLKLGYRDA + DSALYSVGERV+ +R+ Sbjct 362 AFTQHLKLGYRDA-SRCDSALYSVGERVLDMITNRS 396 >gi|342858320|ref|ZP_08714975.1| cobyrinic acid a,c-diamide synthase [Mycobacterium colombiense CECT 3035] gi|342134024|gb|EGT87204.1| cobyrinic acid a,c-diamide synthase [Mycobacterium colombiense CECT 3035] Length=435 Score = 673 bits (1736), Expect = 0.0, Method: Compositional matrix adjust. Identities = 339/430 (79%), Positives = 371/430 (87%), Gaps = 4/430 (0%) Query 32 GHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVL 91 GHTVAPFKVGPDFIDPGYH LAAGRPGRNLDPVLVGE LIGPLYAHG GADIAVIEGV+ Sbjct 2 GHTVAPFKVGPDFIDPGYHGLAAGRPGRNLDPVLVGENLIGPLYAHGARGADIAVIEGVM 61 Query 92 GLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTFDTATRIA 151 GLFDGRIGPA PAAGSTAHVA LLGAPV+LVVDARGQS S+AALLHGFSTFD ATRIA Sbjct 62 GLFDGRIGPAATTPAAGSTAHVAGLLGAPVVLVVDARGQSQSIAALLHGFSTFDAATRIA 121 Query 152 GVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAV 211 GVILNR+GS RHEQVLRQAC+QAGV VLGAIPR AELELPTRYLGL+TAVEYG+RAR AV Sbjct 122 GVILNRIGSDRHEQVLRQACEQAGVPVLGAIPRAAELELPTRYLGLITAVEYGQRAREAV 181 Query 212 QAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTARQPATVAIAAGRAFTFGYAEH 271 AMT +VARHVDLAA+ A AG + A P W+PV AVG T+ ATVA+AAG+AF+FGYAEH Sbjct 182 AAMTELVARHVDLAAMAAVAGGRVAQPAWNPVTAVGETSGGRATVAVAAGKAFSFGYAEH 241 Query 272 AEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGA 331 +E+L AAGA+VVEFDPL++ LP+GTDAV+LPGGFPEQFTAELSAN VRRQIN+LAA GA Sbjct 242 SELLAAAGADVVEFDPLADALPDGTDAVLLPGGFPEQFTAELSANAVVRRQINQLAATGA 301 Query 332 PVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGH 391 P+HAECAGL+YLVSELDGHPMCGV+AG ARFT L L YRDAVAV DS+LY+ G+R VGH Sbjct 302 PIHAECAGLIYLVSELDGHPMCGVLAGRARFTPRLTLAYRDAVAVADSSLYAAGQRAVGH 361 Query 392 EFHRTAVTFADSYQPAWVYQGQDVDD----VRDGAVHSGVHASYLHTHPAATPGAVARFV 447 EFHRTAVTF D YQPAW+Y+ D D VRDG VH+GVHASYLHTHPAA P AV RFV Sbjct 362 EFHRTAVTFTDDYQPAWMYRTHDGDRQGGPVRDGVVHAGVHASYLHTHPAAAPEAVTRFV 421 Query 448 AHAACNTPRA 457 AHA RA Sbjct 422 AHAGARLRRA 431 >gi|254776134|ref|ZP_05217650.1| cobyrinic acid a,c-diamide synthase [Mycobacterium avium subsp. avium ATCC 25291] Length=469 Score = 651 bits (1679), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/438 (81%), Positives = 386/438 (89%), Gaps = 4/438 (0%) Query 13 SGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIG 72 SGSGKTT+ATGLIGALR+AG VA FKVGPDFIDPGYH LAAGRPGRNLDPVLVGE LIG Sbjct 13 SGSGKTTVATGLIGALRRAGRRVAAFKVGPDFIDPGYHGLAAGRPGRNLDPVLVGENLIG 72 Query 73 PLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSH 132 PLYAHG AGADIAV+EGV+GLFDGRIGP+G +PAAGSTAHVAALLGAPV+LVVDARGQS Sbjct 73 PLYAHGAAGADIAVVEGVMGLFDGRIGPSGASPAAGSTAHVAALLGAPVVLVVDARGQSQ 132 Query 133 SVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT 192 S+AALLHGFSTFD ATR+AGVILNRVGSARHEQVLRQAC+QAGV VLGAIPR+AELELPT Sbjct 133 SIAALLHGFSTFDAATRVAGVILNRVGSARHEQVLRQACEQAGVPVLGAIPRSAELELPT 192 Query 193 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGN---T 249 RYLGLVTAVEYGRRARLAV+AMTA+VARHVDLAAV A A ++ PWDP AVG+ Sbjct 193 RYLGLVTAVEYGRRARLAVEAMTALVARHVDLAAVAAVAAARPVTTPWDPAAAVGDPGGC 252 Query 250 ARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQF 309 + ATVA+A G+AF+FGYAEHAE+L AAGA V EFDPL + LP+GTDA++LPGGFPEQF Sbjct 253 GGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLVDALPDGTDALLLPGGFPEQF 312 Query 310 TAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLG 369 TAELSAN+ VRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGV+AG ARFT L L Sbjct 313 TAELSANEVVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVLAGQARFTPQLTLA 372 Query 370 YRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHA 429 YRDAVAVVDS LY+ G+R VGHEFHRT VTF+D Y PAW+Y+ Q+ RDGAV +GVHA Sbjct 373 YRDAVAVVDSPLYAAGQRAVGHEFHRTTVTFSDDYPPAWMYRTQESGH-RDGAVRAGVHA 431 Query 430 SYLHTHPAATPGAVARFV 447 SYLHTHPAA P AVARFV Sbjct 432 SYLHTHPAAAPAAVARFV 449 >gi|118462227|ref|YP_882881.1| cobyrinic acid a,c-diamide synthase [Mycobacterium avium 104] gi|118163514|gb|ABK64411.1| cobyrinic Acid a,c-diamide synthase [Mycobacterium avium 104] Length=470 Score = 648 bits (1671), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/438 (80%), Positives = 386/438 (89%), Gaps = 4/438 (0%) Query 13 SGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIG 72 SGSGKTT+ATGLIGALR+AG VA FKVGPDFIDPGYH LAAGRPGRNLDPVLVGE LIG Sbjct 14 SGSGKTTVATGLIGALRRAGRRVAAFKVGPDFIDPGYHGLAAGRPGRNLDPVLVGENLIG 73 Query 73 PLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSH 132 PLYAHG AGADIAV+EGV+GLFDGRIGP+G +PA+GSTAHVAALLGAPV+LVVDARGQS Sbjct 74 PLYAHGAAGADIAVVEGVMGLFDGRIGPSGASPASGSTAHVAALLGAPVVLVVDARGQSQ 133 Query 133 SVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT 192 S+AALLHGFSTFD ATR+AGVILNRVGSARHEQVLRQAC+QAGV VLGAIPR+AELELPT Sbjct 134 SIAALLHGFSTFDAATRVAGVILNRVGSARHEQVLRQACEQAGVPVLGAIPRSAELELPT 193 Query 193 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGN---T 249 RYLGLVTAVEYGRRARLAV+AMTA+VARH+DLAAV A A ++ PWDP AVG+ Sbjct 194 RYLGLVTAVEYGRRARLAVEAMTALVARHLDLAAVAAVAAARPVATPWDPAAAVGDPGGR 253 Query 250 ARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQF 309 + ATVA+A G+AF+FGYAEHAE+L AAGA V EFDPL + LP+GT+A++LPGGFPEQF Sbjct 254 GGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLVDALPDGTNALLLPGGFPEQF 313 Query 310 TAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLG 369 TAELSAN+ VRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGV+AG ARFT L L Sbjct 314 TAELSANEVVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVLAGQARFTPQLTLA 373 Query 370 YRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHA 429 YRDAVAVVDS LY+ G+R VGHEFHRT VTF+D Y PAW+Y+ Q+ RDGAV +GVHA Sbjct 374 YRDAVAVVDSPLYAAGQRAVGHEFHRTTVTFSDDYLPAWMYRTQESGH-RDGAVRAGVHA 432 Query 430 SYLHTHPAATPGAVARFV 447 SYLHTHPAA P AVARFV Sbjct 433 SYLHTHPAAAPAAVARFV 450 >gi|41409015|ref|NP_961851.1| cobyrinic acid a,c-diamide synthase [Mycobacterium avium subsp. paratuberculosis K-10] gi|41397374|gb|AAS05234.1| CobB [Mycobacterium avium subsp. paratuberculosis K-10] Length=470 Score = 644 bits (1662), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/438 (80%), Positives = 382/438 (88%), Gaps = 4/438 (0%) Query 13 SGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIG 72 SGSGKTT+ATGLIGALR AG VA FKVGPDFIDPGYH L AGRPGRNLDPVLVGE LIG Sbjct 14 SGSGKTTVATGLIGALRGAGRRVAAFKVGPDFIDPGYHGLTAGRPGRNLDPVLVGENLIG 73 Query 73 PLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSH 132 PLYAHG AGADIAV+EGV+GLFDGRIGP+G +PAAGSTAHVAALLGAPV+LVVDARGQS Sbjct 74 PLYAHGAAGADIAVVEGVMGLFDGRIGPSGASPAAGSTAHVAALLGAPVVLVVDARGQSQ 133 Query 133 SVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT 192 S+AALLHGFSTFD ATR+AGVILNRVGSARHEQVLRQA +QAGV VLGAIPR+AELELPT Sbjct 134 SIAALLHGFSTFDAATRVAGVILNRVGSARHEQVLRQASEQAGVPVLGAIPRSAELELPT 193 Query 193 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGN---T 249 RYLGLVTAVEYGRRARLAV+AMTA+VARHVDLAAV A A ++ PWDP AVG+ Sbjct 194 RYLGLVTAVEYGRRARLAVEAMTALVARHVDLAAVAAVAAARPVTTPWDPAAAVGDPGGC 253 Query 250 ARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQF 309 + ATVA+A G+AF+FGYAEHAE+L AAGA V EFDPL + LP+GTDA++LPGGFPEQF Sbjct 254 GGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLVDALPDGTDALLLPGGFPEQF 313 Query 310 TAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLG 369 TAELSAN+ VRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGV+AG ARFT L L Sbjct 314 TAELSANEVVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVLAGQARFTPQLTLA 373 Query 370 YRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHA 429 YRDAVAVVDS LY+ G+R VGHEFHRT VTF+D Y PAW+Y+ Q+ RDGAV GVHA Sbjct 374 YRDAVAVVDSPLYAAGQRAVGHEFHRTTVTFSDDYPPAWMYRTQESGH-RDGAVRGGVHA 432 Query 430 SYLHTHPAATPGAVARFV 447 SYLHTHPAA P AVARFV Sbjct 433 SYLHTHPAAAPAAVARFV 450 >gi|336458987|gb|EGO37939.1| cobyrinic acid a,c-diamide synthase [Mycobacterium avium subsp. paratuberculosis S397] Length=470 Score = 642 bits (1655), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/438 (80%), Positives = 381/438 (87%), Gaps = 4/438 (0%) Query 13 SGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIG 72 SGSGKTT+ATGLIGALR AG VA FKVGPDFIDPGYH LAAGRPGRNLDPVLVGE LIG Sbjct 14 SGSGKTTVATGLIGALRGAGRRVAAFKVGPDFIDPGYHGLAAGRPGRNLDPVLVGENLIG 73 Query 73 PLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSH 132 PLYAHG AGADIAV+EGV+GLFDGRIGP+G +PAAGSTAHVAALLGAPV+LVVDARGQS Sbjct 74 PLYAHGAAGADIAVVEGVMGLFDGRIGPSGASPAAGSTAHVAALLGAPVVLVVDARGQSQ 133 Query 133 SVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT 192 S+AALLHGFSTFD ATR+AGVILNRVGSARHEQVLRQA +QAGV VLGAIPR+AELELPT Sbjct 134 SIAALLHGFSTFDAATRVAGVILNRVGSARHEQVLRQASEQAGVPVLGAIPRSAELELPT 193 Query 193 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGN---T 249 RYLGLVTAVEYGRRARLAV+AMTA+V RHVDLAAV A A ++ PWDP AVG+ Sbjct 194 RYLGLVTAVEYGRRARLAVEAMTALVVRHVDLAAVAAVAAARPVTTPWDPAAAVGDPGGC 253 Query 250 ARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQF 309 + ATVA+A G+AF+FGYAEHAE+L AAGA V EFDPL + LP+GTDA++LPGGFPEQF Sbjct 254 GGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLVDALPDGTDALLLPGGFPEQF 313 Query 310 TAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLG 369 TAELSAN+ VRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGV+AG ARFT L L Sbjct 314 TAELSANEVVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVLAGQARFTPQLTLA 373 Query 370 YRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHA 429 YRDAVAVVDS LY+ G+R VGHEFH T VTF+D Y PAW+Y+ Q+ RDGAV GVHA Sbjct 374 YRDAVAVVDSPLYAAGQRAVGHEFHHTTVTFSDDYPPAWMYRTQESGH-RDGAVRGGVHA 432 Query 430 SYLHTHPAATPGAVARFV 447 SYLHTHPAA P AVARFV Sbjct 433 SYLHTHPAAAPAAVARFV 450 >gi|118468399|ref|YP_886954.1| cobyrinic acid a,c-diamide synthase [Mycobacterium smegmatis str. MC2 155] gi|118169686|gb|ABK70582.1| cobyrinic Acid a,c-diamide synthase [Mycobacterium smegmatis str. MC2 155] Length=458 Score = 631 bits (1628), Expect = 7e-179, Method: Compositional matrix adjust. Identities = 322/448 (72%), Positives = 368/448 (83%), Gaps = 2/448 (0%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 AV +AAPASGSGKTT++TGLIGALR AGHTVAPFKVGPDFIDPGYHA+AAGRPGRNLDPV Sbjct 7 AVVIAAPASGSGKTTVSTGLIGALRAAGHTVAPFKVGPDFIDPGYHAVAAGRPGRNLDPV 66 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILV 124 LVGE LIGPLYAHG AGADIAV+EGV+GLFDGRI GS A VA+LLGAPVILV Sbjct 67 LVGEDLIGPLYAHGSAGADIAVVEGVMGLFDGRICDQMTGTPQGSAAQVASLLGAPVILV 126 Query 125 VDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPR 184 VDARGQS S+AALLHGF+TFD+A +AGVILNRVGS RHE VLRQAC+ AGVAVLGAIPR Sbjct 127 VDARGQSQSIAALLHGFTTFDSAVHVAGVILNRVGSPRHEAVLRQACEHAGVAVLGAIPR 186 Query 185 TAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVI 244 EL +P+R+LGL+TAVE+GR+AR AV AMT +V RHVDLAAV+ACA ++ + PW P + Sbjct 187 ADELSVPSRHLGLITAVEHGRQARDAVAAMTELVGRHVDLAAVMACASARVSAQPWSPCV 246 Query 245 AVGNTARQPA--TVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLP 302 A TVA+A+G+AF+FGYAEHAE+LR GA V EFDPL + LP+G DA+VLP Sbjct 247 ETSFPVADVAGVTVALASGKAFSFGYAEHAELLRGTGATVAEFDPLVDPLPDGADALVLP 306 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPEQFTAELSAND VR+QI+ELA GAP+HAECAGL YLV +LDG PMCGV+ GSA+F Sbjct 307 GGFPEQFTAELSANDLVRQQISELARRGAPIHAECAGLTYLVDDLDGAPMCGVLRGSAKF 366 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGA 422 T+ L LGYRDAVAVVDS++++ GERVVGHEFHRT VTF D PAW + G+ RDGA Sbjct 367 TERLTLGYRDAVAVVDSSMHAAGERVVGHEFHRTTVTFDDDLPPAWAFAGRGGAPARDGA 426 Query 423 VHSGVHASYLHTHPAATPGAVARFVAHA 450 V GVHA YLHTHPAA P A+ARFVA A Sbjct 427 VLRGVHAGYLHTHPAAHPQAIARFVASA 454 >gi|119868155|ref|YP_938107.1| cobyrinic acid a,c-diamide synthase [Mycobacterium sp. KMS] gi|126434643|ref|YP_001070334.1| cobyrinic acid a,c-diamide synthase [Mycobacterium sp. JLS] gi|119694244|gb|ABL91317.1| cobyrinate a,c-diamide synthase [Mycobacterium sp. KMS] gi|126234443|gb|ABN97843.1| hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) / cobyrinate a,c-diamide synthase [Mycobacterium sp. JLS] Length=455 Score = 627 bits (1618), Expect = 1e-177, Method: Compositional matrix adjust. Identities = 321/451 (72%), Positives = 368/451 (82%), Gaps = 2/451 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 M + AV VAAPASGSGKTT+ATGL+GALR+AGH VAPFKVGPDFIDPGYHALAAGRPGRN Sbjct 1 MVIPAVVVAAPASGSGKTTVATGLMGALRRAGHVVAPFKVGPDFIDPGYHALAAGRPGRN 60 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGE LIG LYAHG AGADIAV+EGV+GLFDGRI PA GSTAHVAALLGAP Sbjct 61 LDPVLVGEHLIGALYAHGTAGADIAVVEGVMGLFDGRIADQMSGPATGSTAHVAALLGAP 120 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 V+LVVDARGQSHS+AALLHGFSTFD TRIAGV+LNRVGS RHE+VLRQAC+ AG+ V G Sbjct 121 VVLVVDARGQSHSIAALLHGFSTFDPQTRIAGVVLNRVGSPRHEEVLRQACEHAGLPVFG 180 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 +IPRT L +P+R+LGLVTAVE+GR AR A+ AMT ++ARHVDL AV+A A + PW Sbjct 181 SIPRTEALSVPSRHLGLVTAVEHGRAARDAITAMTDLIARHVDLDAVVAHARATVTDAPW 240 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 DP V + A TVA+AAG+AFTFGY EH E+LRAAGAEVVEFDP+++ LP T A+V Sbjct 241 DP--GVPDPAAPGVTVALAAGKAFTFGYPEHGELLRAAGAEVVEFDPMTDELPADTSALV 298 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 +PGGFPEQ A+LSAN VR+QI +LAA GAP+HAECAGL YLV +LDG PMCGV++G+A Sbjct 299 IPGGFPEQHAADLSANAPVRQQIAQLAALGAPIHAECAGLTYLVDDLDGRPMCGVLSGAA 358 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 RFT+ L LGYR A+A+ DS L+ GERV GHEFHRTAVTF+ Y+ AW + G V D Sbjct 359 RFTERLTLGYRQAIAITDSPLHRAGERVTGHEFHRTAVTFSHRYEAAWHFGGGSTGTVAD 418 Query 421 GAVHSGVHASYLHTHPAATPGAVARFVAHAA 451 GAVH GVHA YLHTHPAA P A+ARFVA AA Sbjct 419 GAVHRGVHAGYLHTHPAAHPDAIARFVASAA 449 >gi|108799040|ref|YP_639237.1| cobyrinic acid a,c-diamide synthase [Mycobacterium sp. MCS] gi|108769459|gb|ABG08181.1| hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) / cobyrinate a,c-diamide synthase [Mycobacterium sp. MCS] Length=454 Score = 626 bits (1614), Expect = 3e-177, Method: Compositional matrix adjust. Identities = 320/449 (72%), Positives = 367/449 (82%), Gaps = 2/449 (0%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 + AV VAAPASGSGKTT+ATGL+GALR+AGH VAPFKVGPDFIDPGYHALAAGRPGRNLD Sbjct 2 IPAVVVAAPASGSGKTTVATGLMGALRRAGHVVAPFKVGPDFIDPGYHALAAGRPGRNLD 61 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 PVLVGE LIG LYAHG AGADIAV+EGV+GLFDGRI PA GSTAHVAALLGAPV+ Sbjct 62 PVLVGEHLIGALYAHGTAGADIAVVEGVMGLFDGRIADQMSGPATGSTAHVAALLGAPVV 121 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDARGQSHS+AALLHGFSTFD TRIAGV+LNRVGS RHE+VLRQAC+ AG+ V G+I Sbjct 122 LVVDARGQSHSIAALLHGFSTFDPQTRIAGVVLNRVGSPRHEEVLRQACEHAGLPVFGSI 181 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP 242 PRT L +P+R+LGLVTAVE+GR AR A+ AMT ++ARHVDL AV+A A + PWDP Sbjct 182 PRTEALSVPSRHLGLVTAVEHGRAARDAITAMTDLIARHVDLDAVVAHARATVTDAPWDP 241 Query 243 VIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLP 302 V + A TVA+AAG+AFTFGY EH E+LRAAGAEVVEFDP+++ LP T A+V+P Sbjct 242 --GVPDPAAPGVTVALAAGKAFTFGYPEHGELLRAAGAEVVEFDPMTDELPADTSALVIP 299 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPEQ A+LSAN VR+QI +LAA GAP+HAECAGL YLV +LDG PMCGV++G+ARF Sbjct 300 GGFPEQHAADLSANAPVRQQIAQLAALGAPIHAECAGLTYLVDDLDGRPMCGVLSGAARF 359 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGA 422 T+ L LGYR A+A+ DS L+ GERV GHEFHRTAVTF+ Y+ AW + G V DGA Sbjct 360 TERLTLGYRQAIAITDSPLHRAGERVTGHEFHRTAVTFSHRYEAAWHFGGGSTGTVADGA 419 Query 423 VHSGVHASYLHTHPAATPGAVARFVAHAA 451 VH GVHA YLHTHPAA P A+ARFVA AA Sbjct 420 VHRGVHAGYLHTHPAAHPDAIARFVASAA 448 >gi|120403295|ref|YP_953124.1| cobyrinic acid a,c-diamide synthase [Mycobacterium vanbaalenii PYR-1] gi|119956113|gb|ABM13118.1| cobyrinate a,c-diamide synthase / hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) [Mycobacterium vanbaalenii PYR-1] Length=460 Score = 612 bits (1579), Expect = 3e-173, Method: Compositional matrix adjust. Identities = 315/440 (72%), Positives = 356/440 (81%), Gaps = 3/440 (0%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 + AV +AAPASGSGKTT+ATGL+GALR AGH VAPFKVGPDFIDPGYHALA RPGRN Sbjct 7 LSTPAVVIAAPASGSGKTTVATGLMGALRLAGHRVAPFKVGPDFIDPGYHALATARPGRN 66 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGE LIGPLY HG ADIAV+EGV+GLFDGRI A PA GSTAHVA+LLGAP Sbjct 67 LDPVLVGESLIGPLYRHGSDDADIAVVEGVMGLFDGRISDAAVGPAQGSTAHVASLLGAP 126 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 V+LVVDARGQSHSVAALLHGF+TFD++ R+AGVILNRVGSARHEQVLRQAC+QAG VLG Sbjct 127 VVLVVDARGQSHSVAALLHGFATFDSSVRLAGVILNRVGSARHEQVLRQACEQAGAVVLG 186 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 +IPR EL +P+R+LGLVTAVE+GRRA AVQAMT +VARHVDLAAV + A S+ PW Sbjct 187 SIPRADELAVPSRHLGLVTAVEHGRRATAAVQAMTELVARHVDLAAVASVASSRVDDAPW 246 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 P T+ TVA+AAGRAF+FGYAEH E+L A+GA+VVEFDPL + LP A+V Sbjct 247 TPPP---RTSPARVTVALAAGRAFSFGYAEHRELLCASGADVVEFDPLCDPLPPDAAALV 303 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPE+F ELSAN+ VR QI LAA GAPV AECAGL YLV +LDGHPMCGV++GSA Sbjct 304 LPGGFPEEFGTELSANEVVREQIRALAAGGAPVQAECAGLTYLVDDLDGHPMCGVLSGSA 363 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRD 420 FT+ L LGYRDAVAV DS L+++G+RVVGHEFHRT V F D+ QPAW Y G+ V D Sbjct 364 SFTESLTLGYRDAVAVADSPLHNIGDRVVGHEFHRTTVHFVDARQPAWRYSGRGAKMVED 423 Query 421 GAVHSGVHASYLHTHPAATP 440 GAV GVHA YLHTHPAA P Sbjct 424 GAVLGGVHAGYLHTHPAAHP 443 >gi|145224628|ref|YP_001135306.1| cobyrinic acid a,c-diamide synthase [Mycobacterium gilvum PYR-GCK] gi|145217114|gb|ABP46518.1| hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) / cobyrinate a,c-diamide synthase [Mycobacterium gilvum PYR-GCK] Length=454 Score = 610 bits (1574), Expect = 1e-172, Method: Compositional matrix adjust. Identities = 319/441 (73%), Positives = 355/441 (81%), Gaps = 5/441 (1%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 M AV +AAP+SGSGKTT+ATGL+GALR+AGH VAPFKVGPDFIDPGYHALA GRPGRN Sbjct 1 MSTPAVVIAAPSSGSGKTTVATGLMGALRRAGHRVAPFKVGPDFIDPGYHALATGRPGRN 60 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVLVGE LIGPLY HG ADIA++EGV+GLFDGRI G PA GSTAHVA LLGAP Sbjct 61 LDPVLVGEPLIGPLYRHGSDDADIAIVEGVMGLFDGRISDGGAGPARGSTAHVAGLLGAP 120 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 V+LVVDARGQSHSVAALLHGF+TFD R+AGVILNRVGS+RH++VLRQACD AGVAVLG Sbjct 121 VVLVVDARGQSHSVAALLHGFATFDQTVRLAGVILNRVGSSRHDEVLRQACDHAGVAVLG 180 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 +IPR EL +P+R+LGLVTA E+GR A AV AMT +VARHVDLAAV A AG A PW Sbjct 181 SIPRADELAVPSRHLGLVTAEEHGRHATAAVAAMTELVARHVDLAAVTAVAGGDVADAPW 240 Query 241 DPV-IAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAV 299 P A G T ATVA+AAG+AFTFGYAEH E+L AAGA+VV FDPL + LP T A+ Sbjct 241 TPAQFAAGPT----ATVALAAGKAFTFGYAEHREILCAAGADVVTFDPLCDPLPAHTSAL 296 Query 300 VLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGS 359 VLPGGFPE+F ELSAN+ VR QI LAAAGAP+HAECAGL YLV ELDGHPMCGV+AGS Sbjct 297 VLPGGFPEEFVTELSANEPVRSQIRALAAAGAPIHAECAGLTYLVDELDGHPMCGVLAGS 356 Query 360 ARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVR 419 A FT L LGYRDAVAV +S+L++VGERV GHEFHRTAV FA Q AW Y+G+ V Sbjct 357 ASFTPSLTLGYRDAVAVAESSLHAVGERVTGHEFHRTAVQFASDRQAAWQYRGRGGAAVE 416 Query 420 DGAVHSGVHASYLHTHPAATP 440 DGAV GVHA YLHTH AA P Sbjct 417 DGAVLGGVHAGYLHTHAAAHP 437 >gi|315444960|ref|YP_004077839.1| hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) ;cobyrinate a,c-diamide synthase [Mycobacterium sp. Spyr1] gi|315263263|gb|ADU00005.1| hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) ;cobyrinate a,c-diamide synthase [Mycobacterium sp. Spyr1] Length=449 Score = 605 bits (1560), Expect = 6e-171, Method: Compositional matrix adjust. Identities = 316/436 (73%), Positives = 353/436 (81%), Gaps = 5/436 (1%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 + +AAP+SGSGKTT+ATGL+GALR+AGH VAPFKVGPDFIDPGYHALA GRPGRNLDPVL Sbjct 1 MVIAAPSSGSGKTTVATGLMGALRRAGHRVAPFKVGPDFIDPGYHALATGRPGRNLDPVL 60 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVV 125 VGE LIGPLY HG ADIA++EGV+GLFDGRI G PA GSTAHVA LLGAPV+LVV Sbjct 61 VGEPLIGPLYRHGSDDADIAIVEGVMGLFDGRISDGGAGPARGSTAHVAGLLGAPVVLVV 120 Query 126 DARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRT 185 DARGQSHSVAALLHGF+TFD R+AGVILNRVGS+RH++VLRQACDQAGVAVLG+IPR Sbjct 121 DARGQSHSVAALLHGFATFDQTVRLAGVILNRVGSSRHDEVLRQACDQAGVAVLGSIPRA 180 Query 186 AELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPV-I 244 EL +P+R+LGLVTA E+GR A AV AMT +V RHVDLAAV A AG A PW P Sbjct 181 DELAVPSRHLGLVTAEEHGRHATAAVAAMTELVTRHVDLAAVTAVAGGDVADAPWTPTQF 240 Query 245 AVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGG 304 A G T ATVA+AAG+AFTFGYAEH E+L AAGA+VV FDPL + LP T A+VLPGG Sbjct 241 AAGPT----ATVALAAGKAFTFGYAEHREILCAAGADVVTFDPLCDPLPVHTSALVLPGG 296 Query 305 FPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQ 364 FPE+F ELSAN+ VR QI LAAAGAP+HAECAGL YLV ELDGHPMCGV+AGSA FT Sbjct 297 FPEEFVTELSANEPVRSQIRALAAAGAPIHAECAGLTYLVDELDGHPMCGVLAGSASFTP 356 Query 365 HLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVH 424 L LGYRDAVAV +S+L++VGERV GHEFHRTAV FA Q AW Y+G+ V DGAV Sbjct 357 SLTLGYRDAVAVAESSLHAVGERVTGHEFHRTAVQFAGDRQAAWQYRGRGGAAVEDGAVL 416 Query 425 SGVHASYLHTHPAATP 440 GVHA YLHTH AA P Sbjct 417 GGVHAGYLHTHAAAHP 432 >gi|226366060|ref|YP_002783843.1| cobyrinic acid a,c-diamide synthase [Rhodococcus opacus B4] gi|226244550|dbj|BAH54898.1| cobyrinic acid a,c-diamide synthase [Rhodococcus opacus B4] Length=465 Score = 539 bits (1389), Expect = 3e-151, Method: Compositional matrix adjust. Identities = 294/458 (65%), Positives = 341/458 (75%), Gaps = 4/458 (0%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V AV +AAPASGSGKTT+ATGL+GALR++G VAPFKVGPD+IDPGYH LAAGRPGRNLD Sbjct 7 VPAVVIAAPASGSGKTTVATGLVGALRESGCAVAPFKVGPDYIDPGYHGLAAGRPGRNLD 66 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPV 121 PV+VG I PLY HG +G+D+AV+EGV+GLFDG+I A P+A GSTA VAALLGAPV Sbjct 67 PVMVGAERIAPLYRHGSSGSDLAVVEGVMGLFDGKIDAASHEPSAEGSTAQVAALLGAPV 126 Query 122 ILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGA 181 +LVVDARG S S+AA+LHGFST+D+ RI GVILNRVGSARHEQVLRQAC++ G+ VLGA Sbjct 127 VLVVDARGHSQSLAAVLHGFSTYDSGVRIGGVILNRVGSARHEQVLRQACERVGLPVLGA 186 Query 182 IPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWD 241 +PR AELE+P+R+LGL+ A E+G A AV AMT + ARH+DL A+ A A S P WD Sbjct 187 VPRMAELEVPSRHLGLIPAAEHGADAVNAVDAMTRLAARHLDLPAIRALAASAVDGPVWD 246 Query 242 PVIAVGNTARQPA-TVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 P VG P TVAIA GRAFTFGYAEH E+L AAGA+V FDPL + LP GT VV Sbjct 247 PAAEVGPPPPGPRPTVAIAGGRAFTFGYAEHRELLGAAGADVTTFDPLHDPLPPGTSGVV 306 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 LPGGFPE+ L+ N + QI ELA AGAP+HAECAGLLYL LDGH M VV A Sbjct 307 LPGGFPEEHAVALAGNAALLAQIRELATAGAPIHAECAGLLYLARSLDGHAMASVVGVDA 366 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRT--AVTFADSYQPAWVYQGQDVDDV 418 F L LGYR+AVAV DSAL++ GERVVGHEFHRT A AD + PAW ++ D Sbjct 367 AFGSRLTLGYREAVAVTDSALFAAGERVVGHEFHRTFLAAAEADGFAPAWGWRPWDGAPA 426 Query 419 RDGAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPR 456 R+G V GVHASYLHTHPA P A+ RFVA A + R Sbjct 427 REGFVRGGVHASYLHTHPAGHPRAITRFVAAARTFSAR 464 >gi|111023575|ref|YP_706547.1| cobyrinic acid a,c-diamide synthase [Rhodococcus jostii RHA1] gi|110823105|gb|ABG98389.1| cobyrinic acid a,c-diamide synthase [Rhodococcus jostii RHA1] Length=465 Score = 536 bits (1381), Expect = 3e-150, Method: Compositional matrix adjust. Identities = 284/442 (65%), Positives = 329/442 (75%), Gaps = 4/442 (0%) Query 13 SGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIG 72 SGSGKTT+ATGL+GALR +G TVAPFKVGPD+IDPGYH LAAGRPGRNLDPV+VG + IG Sbjct 17 SGSGKTTVATGLVGALRASGCTVAPFKVGPDYIDPGYHGLAAGRPGRNLDPVMVGAQRIG 76 Query 73 PLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPVILVVDARGQS 131 PLY HG +G D+AV+EGV+GLFDG+I A P+A GSTA VAALLGAPV+LVVDARG S Sbjct 77 PLYRHGSSGCDLAVVEGVMGLFDGKIDAASQEPSAEGSTAQVAALLGAPVVLVVDARGHS 136 Query 132 HSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELP 191 S+AA+LHGFST+D+ RI GVILNRVGS RHEQVLRQAC++ G+ VLGA+PR AELE+P Sbjct 137 QSLAAILHGFSTYDSGVRIGGVILNRVGSPRHEQVLRQACERVGLPVLGAVPRMAELEVP 196 Query 192 TRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTAR 251 +R+LGL+ A E+G A AV AMT + ARH+DL A+ A A S P WDP G Sbjct 197 SRHLGLIPAAEHGADAVDAVDAMTRLAARHLDLPAIRALASSAVDGPVWDPAAEAGPILP 256 Query 252 QP-ATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQFT 310 P VAIA GRAFTFGYAEH E+L AAGA+V+ FDPL + LP GT VVLPGGFPE+ Sbjct 257 GPRPVVAIAGGRAFTFGYAEHRELLGAAGADVITFDPLHDGLPPGTSGVVLPGGFPEEHA 316 Query 311 AELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGY 370 L+ N + QI ELA AGAP+HAECAGLLYL LDGH M VV A F L LGY Sbjct 317 VALAENSVLLTQIRELATAGAPIHAECAGLLYLARSLDGHAMASVVGVDASFGSRLTLGY 376 Query 371 RDAVAVVDSALYSVGERVVGHEFHRT--AVTFADSYQPAWVYQGQDVDDVRDGAVHSGVH 428 R+AVAV DS L++ GERVVGHEFHRT A AD + PAW ++ D R+G V GVH Sbjct 377 REAVAVTDSVLFAAGERVVGHEFHRTSLAAAEADGFAPAWGWRPWDGHPAREGFVRGGVH 436 Query 429 ASYLHTHPAATPGAVARFVAHA 450 ASYLHTHPA P A+ RFVA A Sbjct 437 ASYLHTHPAGHPEAITRFVAAA 458 >gi|325673404|ref|ZP_08153095.1| cobyrinic Acid a,c-diamide synthase [Rhodococcus equi ATCC 33707] gi|325555425|gb|EGD25096.1| cobyrinic Acid a,c-diamide synthase [Rhodococcus equi ATCC 33707] Length=460 Score = 534 bits (1376), Expect = 1e-149, Method: Compositional matrix adjust. Identities = 282/447 (64%), Positives = 332/447 (75%), Gaps = 4/447 (0%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 AV +AAPASGSGKTT+ATGL+GALR AG VAPFKVGPD+IDPGYHALAAG PGRNLD V Sbjct 9 AVVIAAPASGSGKTTVATGLVGALRAAGDRVAPFKVGPDYIDPGYHALAAGLPGRNLDSV 68 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPVIL 123 LVG IGPL+ HG DIAV+EGV+GLFDG+I P+ AP+A GSTA VAA LGAPV+L Sbjct 69 LVGADRIGPLFRHGGDDCDIAVVEGVMGLFDGKIDPSSSAPSAEGSTAQVAAALGAPVVL 128 Query 124 VVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIP 183 V+DARG S S+AA+LHGFST+D+A RI GVILNRVGSARHEQVLRQAC++ G+ VLGA+P Sbjct 129 VIDARGHSQSLAAVLHGFSTYDSAVRIGGVILNRVGSARHEQVLRQACERVGLPVLGAVP 188 Query 184 RTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPV 243 R AELE+P+R+LGLV AVE+GR A AV AMT + A H+DL A+ A S WDP Sbjct 189 RLAELEVPSRHLGLVPAVEHGRAALDAVAAMTELAAAHLDLDAIRGLAHSSVGDVAWDPA 248 Query 244 IAVGNTARQP-ATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLP 302 +G P +A+A G AFTFGYAEH E+L AAGA+VV FDPL + LP GT +VLP Sbjct 249 AEIGPVPSGPRPVIALAGGVAFTFGYAEHRELLDAAGADVVVFDPLHDELPAGTAGLVLP 308 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPE+ LSAN + +Q+ +LAA GAP+HAECAGLLYL LDGH M GV+ ARF Sbjct 309 GGFPEEHAVALSANRVLLQQVRQLAADGAPIHAECAGLLYLTRSLDGHAMAGVIDVDARF 368 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVT--FADSYQPAWVYQGQDVDDVRD 420 + L LGYR+AVAV DS L+ G RV GHEFHRTA+ AD + PAW ++ D R+ Sbjct 369 GKRLTLGYREAVAVTDSVLFGAGTRVTGHEFHRTALDAGVADGFGPAWGWRAWDAGATRE 428 Query 421 GAVHSGVHASYLHTHPAATPGAVARFV 447 G VHASYLHTHPA P A+ RFV Sbjct 429 GFTAGSVHASYLHTHPAGNPDAIRRFV 455 >gi|312139290|ref|YP_004006626.1| cobyrinate-a,c-diamine synthase cobb [Rhodococcus equi 103S] gi|311888629|emb|CBH47941.1| cobyrinate-a,c-diamine synthase CobB [Rhodococcus equi 103S] Length=459 Score = 532 bits (1370), Expect = 6e-149, Method: Compositional matrix adjust. Identities = 280/447 (63%), Positives = 330/447 (74%), Gaps = 4/447 (0%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 AV +AAPASGSGKTT+ATGL+GALR G VAPFKVGPD+IDPGYHALAAG PGRNLD V Sbjct 8 AVVIAAPASGSGKTTVATGLVGALRATGDRVAPFKVGPDYIDPGYHALAAGLPGRNLDSV 67 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPVIL 123 LVG IGPL+ HG DIAV+EGV+GLFDG+I P+ P+A GSTA VAA LGAPV+L Sbjct 68 LVGADRIGPLFRHGSDDCDIAVVEGVMGLFDGKIDPSSSVPSAEGSTAQVAAALGAPVVL 127 Query 124 VVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIP 183 V+DARG S S+AA+LHGFST+D+A RI GVILNRVGSARHEQVLRQAC++ G+ VLGA+P Sbjct 128 VIDARGHSQSLAAVLHGFSTYDSAVRIGGVILNRVGSARHEQVLRQACERVGLPVLGAVP 187 Query 184 RTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPV 243 R AELE+P+R+LGLV AVE+GR A AV AMT + A H+DL A+ A S WDP Sbjct 188 RLAELEVPSRHLGLVPAVEHGRAALDAVAAMTELAAAHLDLDAIRGLAHSSVGDVAWDPA 247 Query 244 IAVGNTARQP-ATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLP 302 +G P +A+A G AFTFGYAEH E+L AAGA+VV FDPL + LP GT +VLP Sbjct 248 AEIGPVPSGPRPVIALAGGVAFTFGYAEHRELLDAAGADVVVFDPLHDELPTGTAGLVLP 307 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPE+ LSAN + +Q+ +LAA GAP+HAECAGLLYL LDGH M GV+ ARF Sbjct 308 GGFPEEHAVALSANRVLLQQVRQLAADGAPIHAECAGLLYLTRSLDGHAMVGVIDVDARF 367 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVT--FADSYQPAWVYQGQDVDDVRD 420 + L LGYR+AVAV DS L+ G RV GHEFHRTA+ AD + PAW ++ D R+ Sbjct 368 GKRLTLGYREAVAVTDSVLFGAGTRVTGHEFHRTALDAGVADGFGPAWGWRAWDAGATRE 427 Query 421 GAVHSGVHASYLHTHPAATPGAVARFV 447 G VHASYLHTHPA P A+ RFV Sbjct 428 GFTAGSVHASYLHTHPAGNPDAIRRFV 454 >gi|226306095|ref|YP_002766055.1| cobyrinic acid a,c-diamide synthase [Rhodococcus erythropolis PR4] gi|226185212|dbj|BAH33316.1| cobyrinic acid a,c-diamide synthase [Rhodococcus erythropolis PR4] Length=458 Score = 521 bits (1343), Expect = 8e-146, Method: Compositional matrix adjust. Identities = 277/446 (63%), Positives = 334/446 (75%), Gaps = 3/446 (0%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 AV +AAPASGSGKTT+ATGLIGALR++G +VAPFKVGPD+IDPGYH LAAGRPGRNLD V Sbjct 8 AVVIAAPASGSGKTTVATGLIGALRRSGSSVAPFKVGPDYIDPGYHGLAAGRPGRNLDTV 67 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPVIL 123 LVG IGPLY HG AG DIAV+EGV+GLFDG+I A P+A GSTA VA++LG+PV+L Sbjct 68 LVGPDRIGPLYRHGTAGCDIAVVEGVMGLFDGKIDEANSQPSAEGSTAQVASILGSPVVL 127 Query 124 VVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIP 183 V+DARG S S+AA+LHGF+T+D RI GVILNRVGSARHEQVLR ACD+ GVAVLG +P Sbjct 128 VIDARGHSQSLAAVLHGFATYDAGVRIGGVILNRVGSARHEQVLRHACDKVGVAVLGVVP 187 Query 184 RTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPV 243 R ELE+P+R+LGL+ A E+G A AV AM+ ++A HV+L AV A A S WDPV Sbjct 188 RLTELEVPSRHLGLIPAAEHGAAAVAAVDAMSDLIASHVELDAVRALAASNVGAAAWDPV 247 Query 244 IAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPG 303 VG A VA+A G AFTFGYAEH E+L AAGA+V FDPL + LP GT A+VLPG Sbjct 248 AEVGAHAESRPVVAMAGGPAFTFGYAEHRELLTAAGADVQVFDPLRDELPAGTAALVLPG 307 Query 304 GFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFT 363 GFPE+ +L+AN + +Q+ +LA GAP+HAECAGLLYL LDGH M GVV A F Sbjct 308 GFPEEHAVDLAANTVLLQQVRDLADGGAPIHAECAGLLYLARSLDGHSMAGVVGVDATFG 367 Query 364 QHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADS--YQPAWVYQGQDVDDVRDG 421 + L LGYR+AVA+ DS+L+ G RV GHEFHRT++ AD+ AW ++ D VR+G Sbjct 368 KRLTLGYREAVAISDSSLFEAGFRVTGHEFHRTSLVSADADGCGSAWGWRPWDGGSVREG 427 Query 422 AVHSGVHASYLHTHPAATPGAVARFV 447 V GVHASYLHTHP P ++A+FV Sbjct 428 FVRGGVHASYLHTHPVGQPESIAKFV 453 >gi|229491361|ref|ZP_04385185.1| cobyrinic Acid a,c-diamide synthase [Rhodococcus erythropolis SK121] gi|229321646|gb|EEN87443.1| cobyrinic Acid a,c-diamide synthase [Rhodococcus erythropolis SK121] Length=450 Score = 516 bits (1330), Expect = 2e-144, Method: Compositional matrix adjust. Identities = 276/445 (63%), Positives = 334/445 (76%), Gaps = 3/445 (0%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 + +AAPASGSGKTT+ATGLIGALR++G +VAPFKVGPD+IDPGYH LAAGRPGRNLD VL Sbjct 1 MVIAAPASGSGKTTVATGLIGALRRSGSSVAPFKVGPDYIDPGYHGLAAGRPGRNLDTVL 60 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPVILV 124 VG IGPLY HG AG DIAV+EGV+GLFDG+I A P+A GSTA VA++LG+PV+LV Sbjct 61 VGPDRIGPLYRHGTAGCDIAVVEGVMGLFDGKIDEANSQPSAEGSTAQVASILGSPVVLV 120 Query 125 VDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPR 184 +DARG S S+AA+LHGF+T+D RI GVILNRVGSARHEQVLR ACD+ GVAVLG +PR Sbjct 121 IDARGHSQSLAAVLHGFATYDAGVRIGGVILNRVGSARHEQVLRHACDKVGVAVLGVVPR 180 Query 185 TAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVI 244 ELE+P+R+LGL+ A E+G A AV AM+ ++A HVDL AV A A S + WDPV Sbjct 181 LTELEVPSRHLGLIPAAEHGAAAVAAVDAMSDLIASHVDLGAVRALAASNLSAAAWDPVA 240 Query 245 AVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGG 304 VG A VA+A G AFTFGYAEH E+L AAGA+V FDPL + LP GT A+VLPGG Sbjct 241 EVGAHAESRPVVAMAGGPAFTFGYAEHRELLTAAGADVQVFDPLRDELPAGTAALVLPGG 300 Query 305 FPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQ 364 FPE+ +L+AN + +Q+ +LA GAP+HAECAGLLYL LDGH M GVV A F + Sbjct 301 FPEEHAVDLAANTVLLQQVRDLADGGAPIHAECAGLLYLARRLDGHSMAGVVGVDATFGK 360 Query 365 HLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADS--YQPAWVYQGQDVDDVRDGA 422 L LGYR+AVA+ DS+L+ G RV GHEFHRT++ AD+ AW ++ D VR+G Sbjct 361 RLTLGYREAVAISDSSLFEAGSRVTGHEFHRTSLVSADADGCGSAWGWRPWDGGSVREGF 420 Query 423 VHSGVHASYLHTHPAATPGAVARFV 447 V GVHASYLHTHP P ++A+FV Sbjct 421 VRGGVHASYLHTHPVGQPESIAKFV 445 >gi|54026052|ref|YP_120294.1| cobyrinic acid a,c-diamide synthase [Nocardia farcinica IFM 10152] gi|54017560|dbj|BAD58930.1| putative cobyrinic acid a,c-diamide synthase [Nocardia farcinica IFM 10152] Length=474 Score = 513 bits (1320), Expect = 3e-143, Method: Compositional matrix adjust. Identities = 278/449 (62%), Positives = 319/449 (72%), Gaps = 14/449 (3%) Query 13 SGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIG 72 SGSGKTT+ATGLIGALR+AGH VAPFKVGPD+IDPGYH LAAGRPGRNLDPVLVG I Sbjct 15 SGSGKTTLATGLIGALRRAGHRVAPFKVGPDYIDPGYHGLAAGRPGRNLDPVLVGAERIA 74 Query 73 PLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA-GSTAHVAALLGAPVILVVDARGQS 131 PLY HG G D+AV+EGV+GLFDGRI AP A GSTA VA LLGAPV+LVVDARG S Sbjct 75 PLYRHGTVGCDLAVVEGVMGLFDGRIDEGDPAPVAEGSTAQVAGLLGAPVVLVVDARGHS 134 Query 132 HSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELP 191 S+AALLHGF+TFD+ R+ GVILNRVGS RHEQVLR AC + G+ VLGA+PR LE+P Sbjct 135 QSLAALLHGFATFDSGVRLGGVILNRVGSERHEQVLRAACARVGLPVLGALPRMGALEVP 194 Query 192 TRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAV----- 246 +R+LGL+ AVE+GR A AV AMT +VA HVDL AV A A A P WDP V Sbjct 195 SRHLGLIPAVEHGRAATDAVAAMTDLVAAHVDLGAVAALARCTVAEPAWDPADVVRTAPA 254 Query 247 ---GNTARQPA-----TVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDA 298 G T QPA +A+A G AFTFGYAEH E+L AAGA VV FDPL + LP G Sbjct 255 DHRGTTDAQPAAADGPVIAMAGGPAFTFGYAEHRELLAAAGARVVVFDPLRDELPTGAAG 314 Query 299 VVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAG 358 +VLPGGFPE+ A L+AN + ++ E AAAG P+HAECAGLLYL LDGH + GVV Sbjct 315 LVLPGGFPEEHAAALAANTPLLTEVRERAAAGLPIHAECAGLLYLTRSLDGHALAGVVDA 374 Query 359 SARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDV 418 A F L LGYR+AVA+ DS L+ GERV GHEFHRT + A +PAW ++ V Sbjct 375 EAEFGPRLTLGYREAVALADSPLWQAGERVRGHEFHRTRLITAVVDRPAWGWRDPAGATV 434 Query 419 RDGAVHSGVHASYLHTHPAATPGAVARFV 447 R+G + VHASYLHTHPA P A RFV Sbjct 435 REGLLTRRVHASYLHTHPAGNPSATVRFV 463 >gi|169630237|ref|YP_001703886.1| cobyrinic acid A,C-diamide synthase CobB [Mycobacterium abscessus ATCC 19977] gi|169242204|emb|CAM63232.1| Probable cobyrinic acid A,C-diamide synthase (CobB) [Mycobacterium abscessus] Length=453 Score = 501 bits (1289), Expect = 1e-139, Method: Compositional matrix adjust. Identities = 275/453 (61%), Positives = 332/453 (74%), Gaps = 14/453 (3%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 + +AAPASGSGKTT+ATGL+GALR AGH VAPFKVGPD+IDPGYHALA GRPGRNLD VL Sbjct 1 MVIAAPASGSGKTTVATGLMGALRHAGHRVAPFKVGPDYIDPGYHALATGRPGRNLDSVL 60 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVV 125 VG+ LIGPL+ HG ADIAV+EGV+GLFDGR+G A GSTA +AALLGAPV+LVV Sbjct 61 VGDDLIGPLFRHGSRNADIAVVEGVMGLFDGRVGDA-----KGSTAEIAALLGAPVVLVV 115 Query 126 DARGQSHSVAALLHGFSTF--DTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIP 183 DA+G S S++ALLHGF + RIAGVILNRVGSARH +L A D+AG+ V GA+P Sbjct 116 DAKGYSQSLSALLHGFVAHAAEAGIRIAGVILNRVGSARHRDILTAAADRAGLRVFGALP 175 Query 184 RTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPV 243 RT EL +P+R+LGLVTAVE+G+ A A+ AM +VA HV++ A+ A A S P W+P Sbjct 176 RTDELSVPSRHLGLVTAVEHGQAALGAISAMAQLVATHVNVGAIAAAAHSDVTSPIWEPA 235 Query 244 IAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPG 303 AVG + VA+AAG+AFTFGYAEH E+L AAGA V EFDP S++LP T A+V+PG Sbjct 236 EAVGAPTDREPVVALAAGQAFTFGYAEHRELLAAAGALVAEFDPRSDSLPAETAALVIPG 295 Query 304 GFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFT 363 GFPEQF +LSAN T+R+Q+ E+ P+HAECAGL YL +LDG PMCGV+ ARFT Sbjct 296 GFPEQFATDLSANATLRQQVGEMV---GPIHAECAGLTYLCRDLDGVPMCGVLDARARFT 352 Query 364 QHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGA 422 L LGYR+AVA+ S L+ GER+ GHEFHRT V + + P AW ++ D R+G Sbjct 353 DSLTLGYREAVALTGSVLFEEGERLSGHEFHRTTVDYPEDGAPRAWAWRTAD-GVRREGT 411 Query 423 V--HSGVHASYLHTHPAATPGAVARFVAHAACN 453 V +HASYLHTHPAA P A ARFVA AA Sbjct 412 VVGEGRIHASYLHTHPAAHPSATARFVARAAAT 444 >gi|256379854|ref|YP_003103514.1| cobyrinic acid a,c-diamide synthase [Actinosynnema mirum DSM 43827] gi|255924157|gb|ACU39668.1| cobyrinic acid a,c-diamide synthase [Actinosynnema mirum DSM 43827] Length=465 Score = 490 bits (1262), Expect = 2e-136, Method: Compositional matrix adjust. Identities = 280/463 (61%), Positives = 324/463 (70%), Gaps = 19/463 (4%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 +SA+ VAAPASGSGKTT+ATGL+ ALR+AG VAPFKVGPD+IDPGYHALA GRPGRNLD Sbjct 1 MSALVVAAPASGSGKTTVATGLMAALRRAGDAVAPFKVGPDYIDPGYHALATGRPGRNLD 60 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 PV+VGE + L+AHG GAD+AV+EGV+GLFDGRI G GSTAHVA LLGAPV+ Sbjct 61 PVMVGEHRVPELFAHGARGADLAVVEGVMGLFDGRIDTDG----VGSTAHVAKLLGAPVL 116 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 VVDARGQS S+AALLHGF +D R+ GV+LN+VGS RHEQVLR AC G+ VLG + Sbjct 117 FVVDARGQSRSLAALLHGFRGYDPGVRLGGVVLNQVGSPRHEQVLRSACADVGLDVLGVL 176 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAG--SQAAHPPW 240 PR LP+R+LGLVTA E+G A AV+A+ V HVDLAA+ A A + A W Sbjct 177 PRDDRFALPSRHLGLVTAAEHGHEAVAAVEAVADAVGAHVDLAAIRALAATANPVAARAW 236 Query 241 DP------VIAVGNTARQPA----TVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPL-S 289 DP V+ + R P +A+A G AFTFGYAEH E+LRAAGA+VV FDPL Sbjct 237 DPDAEIAAVVESSSAPRVPVGSRPVIAVAGGPAFTFGYAEHPELLRAAGADVVVFDPLRD 296 Query 290 ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDG 349 ETLP T ++LPGGFPEQ AELSAN+ +R I LA AGAPVHAEC GLLYL LDG Sbjct 297 ETLPANTSGLLLPGGFPEQHAAELSANEPLRATITALARAGAPVHAECGGLLYLAKSLDG 356 Query 350 HPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWV 409 PMCGVV A T L LGYRDAVA VDS L VG RV GHEFHRTA++ PAW Sbjct 357 APMCGVVDSEAAMTPRLVLGYRDAVAPVDSVLLPVGARVTGHEFHRTALSTPHGADPAWR 416 Query 410 YQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHAAC 452 ++G D +G V VHASYLHTHPA+ P + RF AAC Sbjct 417 WRGHDGRPAAEGFVLGNVHASYLHTHPASIPESAHRFT--AAC 457 >gi|134102409|ref|YP_001108070.1| cobyrinic acid a,c-diamide synthase [Saccharopolyspora erythraea NRRL 2338] gi|291004206|ref|ZP_06562179.1| cobyrinic acid a,c-diamide synthase [Saccharopolyspora erythraea NRRL 2338] gi|133915032|emb|CAM05145.1| cobyrinic acid a,c-diamide synthase [Saccharopolyspora erythraea NRRL 2338] Length=469 Score = 489 bits (1260), Expect = 3e-136, Method: Compositional matrix adjust. Identities = 275/444 (62%), Positives = 316/444 (72%), Gaps = 6/444 (1%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 V VAAP SG GKTT+ATGL+ ALR+ VAPFKVGPD+IDPGYH +AAGR RNLDPVL Sbjct 14 VVVAAPGSGHGKTTVATGLLAALRRRSAAVAPFKVGPDYIDPGYHRVAAGRAARNLDPVL 73 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVV 125 VGE+ I PL+ HG AGA ++V+EGV+GLFDGRIG G PA GSTAHVA LL APV+LVV Sbjct 74 VGEQRIVPLFKHGAAGAGLSVVEGVMGLFDGRIGTGGDGPAFGSTAHVAGLLDAPVVLVV 133 Query 126 DARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRT 185 DA GQS S+AALLHGF TF RI GVILNRVGSARHE+VLR+A + AG+ V GA+PRT Sbjct 134 DASGQSQSLAALLHGFRTFQPGVRIGGVILNRVGSARHEEVLREAAEVAGLPVFGALPRT 193 Query 186 AELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAA--HPPWDPV 243 L +P+R+LGLVTA E+G A V AM VV + VDL +V A A S A W P Sbjct 194 EGLRVPSRHLGLVTAAEHGGEATRVVSAMADVVEQSVDLDSVAALAESAPALTGDVWSPE 253 Query 244 IAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPL-SETLPEGTDAVVLP 302 V P VA+A G AFTFGYAEH E+L AAGAEVV DP E LP GT +VLP Sbjct 254 EEVRRVGGSP-VVAVAGGPAFTFGYAEHVELLAAAGAEVVVVDPTRDERLPGGTAGLVLP 312 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPEQ AELSAN +R+ I + AA+G PVHAEC GLLYLV ELDGHPMCGV+ A Sbjct 313 GGFPEQHVAELSANSLLRKDIADFAASGGPVHAECGGLLYLVDELDGHPMCGVLRARAAM 372 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGA 422 + L LGYRDAVA DS L++ GER+ GHEFHRT + +PAW ++ V +G Sbjct 373 SPKLTLGYRDAVAATDSVLFAEGERISGHEFHRTVLEPGAGERPAWRWRAGGV--TAEGF 430 Query 423 VHSGVHASYLHTHPAATPGAVARF 446 VHSGVHASYLHTHPA P AV RF Sbjct 431 VHSGVHASYLHTHPAGGPDAVFRF 454 >gi|333919279|ref|YP_004492860.1| Cobyrinic acid a,c-diamide synthase [Amycolicicoccus subflavus DQS3-9A1] gi|333481500|gb|AEF40060.1| Cobyrinic acid a,c-diamide synthase [Amycolicicoccus subflavus DQS3-9A1] Length=467 Score = 480 bits (1236), Expect = 2e-133, Method: Compositional matrix adjust. Identities = 256/447 (58%), Positives = 318/447 (72%), Gaps = 8/447 (1%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 M V AV +AAP+SGSGKTT+ATG++ ALR +G VAPFKVGPD+IDPGYH+LA GRPGRN Sbjct 1 MTVPAVVLAAPSSGSGKTTLATGIMAALRASGLRVAPFKVGPDYIDPGYHSLATGRPGRN 60 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LDPVL L+GPL+ HG AG DIA++EGV+GLFDGRIG A A GSTA VAALLGAP Sbjct 61 LDPVLTSPELVGPLFQHGSAGCDIAIVEGVMGLFDGRIGSA--ELAEGSTAQVAALLGAP 118 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 V+LVVD RG S S+AALLHGF+TFD RIAGVILN+VGS RHE VLR+ACD+AG+ VLG Sbjct 119 VVLVVDVRGHSQSLAALLHGFATFDPRVRIAGVILNQVGSDRHEHVLREACDRAGMPVLG 178 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 +PR + LP+R+LGLVTA E+G A A++AM + +DL + A S W Sbjct 179 VVPRDGNVSLPSRHLGLVTAAEHGGAADAAIRAMGELARSCIDLPGLRQIARSAVLAEAW 238 Query 241 DPVIAVGNTA-----RQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEG 295 P A+G ++ R+P +A+A+G AFTF YAEH E+LRAAGA++ FDPLS+ LPEG Sbjct 239 SPGGALGESSGAGYQRRP-VIAVASGPAFTFRYAEHDELLRAAGADIAVFDPLSDGLPEG 297 Query 296 TDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGV 355 T +VLPGGFPE + A L+ N + Q+ + AAA P+ AECAGLLYL ++D +PM GV Sbjct 298 TTGIVLPGGFPELYAAALAENVALLSQVRDAAAAEVPIVAECAGLLYLSRKVDLYPMAGV 357 Query 356 VAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDV 415 +A A F + L LGYRDA A+ DS + GERV GHEFHRT + + AW ++ Sbjct 358 IAADAVFGKRLVLGYRDAAALSDSVAFRAGERVTGHEFHRTHLLENERTDAAWGWRDHAG 417 Query 416 DDVRDGAVHSGVHASYLHTHPAATPGA 442 VR+G V + VHASYLHTHPA P + Sbjct 418 ALVREGFVGNSVHASYLHTHPAGHPSS 444 >gi|262202070|ref|YP_003273278.1| cobyrinic acid a,c-diamide synthase [Gordonia bronchialis DSM 43247] gi|262085417|gb|ACY21385.1| cobyrinic acid a,c-diamide synthase [Gordonia bronchialis DSM 43247] Length=476 Score = 479 bits (1233), Expect = 4e-133, Method: Compositional matrix adjust. Identities = 268/448 (60%), Positives = 309/448 (69%), Gaps = 8/448 (1%) Query 12 ASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLI 71 +SGSGKTT+ TGLIGALR AGH VAPFKVGPD+IDPGYHA+AAGR GRNLD LVG I Sbjct 13 SSGSGKTTVTTGLIGALRAAGHRVAPFKVGPDYIDPGYHAVAAGRVGRNLDSNLVGAEQI 72 Query 72 GPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPA--AGSTAHVAALLGAPVILVVDARG 129 L+A G AGADIAV+EGV+GLFDGRI A + GSTAHVA L+GAPVILVVDA G Sbjct 73 PALFAAGSAGADIAVVEGVMGLFDGRITDDADADSLGTGSTAHVATLIGAPVILVVDAAG 132 Query 130 QSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELE 189 S S+AA+LHGF ++ + RIAGV+LNRVGS RHEQVLRQAC + GV V G + R L Sbjct 133 HSQSLAAVLHGFLGYEPSVRIAGVVLNRVGSPRHEQVLRQACARVGVPVFGVLRRDPSLA 192 Query 190 LPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAH--PPW---DPVI 244 +P+R+LGL+ A E A LAV AMTA V +DL A++A A S P W D + Sbjct 193 VPSRHLGLIPAAERTTEAVLAVDAMTAGVGAALDLPAIVAAASSSTRRMAPAWSASDALN 252 Query 245 AVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGG 304 A G +A+AAG AFTFGYAEH EMLRAAGA+VVEFDPL++ LP G VV+ GG Sbjct 253 AQGPPPENRPLIAVAAGAAFTFGYAEHTEMLRAAGADVVEFDPLADRLPVGCAGVVIGGG 312 Query 305 FPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQ 364 FPE+ LSAND++RR + EL G PVHAECAGLLYL + LDGHPM GV+ F Sbjct 313 FPEEHAEALSANDSLRRDLRELTTRGGPVHAECAGLLYLAARLDGHPMSGVLDVDGHFGP 372 Query 365 HLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVT-FADSYQPAWVYQGQDVDDVRDGAV 423 L LGYRDAVAV DS LY G+RV GHEFHR+ VT A S PAW + G D G Sbjct 373 TLTLGYRDAVAVTDSVLYRSGDRVTGHEFHRSQVTARAASLPPAWGWSGADGRPSVHGVA 432 Query 424 HSGVHASYLHTHPAATPGAVARFVAHAA 451 VHASYLH HP A P A+ RFV AA Sbjct 433 TGSVHASYLHVHPVAVPAAIRRFVHRAA 460 >gi|296139416|ref|YP_003646659.1| cobyrinic acid a,c-diamide synthase [Tsukamurella paurometabola DSM 20162] gi|296027550|gb|ADG78320.1| cobyrinic acid a,c-diamide synthase [Tsukamurella paurometabola DSM 20162] Length=441 Score = 478 bits (1229), Expect = 1e-132, Method: Compositional matrix adjust. Identities = 266/442 (61%), Positives = 309/442 (70%), Gaps = 5/442 (1%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 + +AAP+SGSGKTTIATGL+GAL + G TVAPFKVGPD+IDPGYHALA GR GRNLDPVL Sbjct 1 MVIAAPSSGSGKTTIATGLMGALARTG-TVAPFKVGPDYIDPGYHALATGRSGRNLDPVL 59 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVV 125 G+ I PLY HG A AD+AV+EGV+GL+DGRI G GSTA VA LGAPVILVV Sbjct 60 CGDHRIAPLYRHGAAEADVAVVEGVMGLYDGRITADGRTQGIGSTADVAESLGAPVILVV 119 Query 126 DARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRT 185 D RG S S+AALL GF+T+ +AGVILNRV S RHE+VLR AC Q G+ LGA+P Sbjct 120 DVRGHSQSLAALLAGFATYRPGIAVAGVILNRVSSPRHERVLRDACAQVGLEALGAVPGA 179 Query 186 AELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIA 245 AELE+P R+LGL+ A E G A AV AMT +VARHVD+ + A A P WDP Sbjct 180 AELEVPARHLGLIPAAERGAAAVDAVAAMTDLVARHVDVDRIRDLARPVPAGPAWDPSAE 239 Query 246 VGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGF 305 V TVA+A G AF+FGYAEH ++L AAGA V FDPL++ LP G AVVLPGGF Sbjct 240 VARVGGP--TVALAGGPAFSFGYAEHEDLLTAAGARVQRFDPLTDELPGGAAAVVLPGGF 297 Query 306 PEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQH 365 PE + +L+AN +R QI L A G VHAECAGLLYL LDG PMCGVV G+A FT Sbjct 298 PEVYAEKLAANTALREQIRRLVADGGLVHAECAGLLYLAESLDGVPMCGVVPGAASFTPR 357 Query 366 LKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHS 425 L+LGYRDAVA+ +L++VGERV GHEFHRTA A S PAW ++ D V DG V Sbjct 358 LRLGYRDAVALTAGSLFAVGERVTGHEFHRTA--LAPSGTPAWGWRDGDGAPVTDGHVAP 415 Query 426 GVHASYLHTHPAATPGAVARFV 447 GVH+SYLH HPA P R V Sbjct 416 GVHSSYLHVHPAGYPEVAERLV 437 >gi|326382926|ref|ZP_08204616.1| cobyrinic acid a,c-diamide synthase [Gordonia neofelifaecis NRRL B-59395] gi|326198516|gb|EGD55700.1| cobyrinic acid a,c-diamide synthase [Gordonia neofelifaecis NRRL B-59395] Length=464 Score = 477 bits (1227), Expect = 2e-132, Method: Compositional matrix adjust. Identities = 267/446 (60%), Positives = 316/446 (71%), Gaps = 8/446 (1%) Query 8 VAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVG 67 +AAPASGSGKTT+ TGLIGAL AGH VAPFKVGPD+IDPGYH +AAGR GRNLDP LVG Sbjct 2 IAAPASGSGKTTVTTGLIGALVAAGHRVAPFKVGPDYIDPGYHGVAAGRVGRNLDPNLVG 61 Query 68 ERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDA 127 LI PLYA A ADIAV+EGV+GLFDGRI GSTAHVA L+GAPV+LVVDA Sbjct 62 ADLIAPLYAAATADADIAVVEGVMGLFDGRITDDPDPLGVGSTAHVATLIGAPVVLVVDA 121 Query 128 RGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAE 187 G S S+AA+LHGF +++ R+AGVILNRVGS RHEQVLRQAC++ G+ VLG + R A+ Sbjct 122 GGHSQSLAAVLHGFLGYESRVRVAGVILNRVGSPRHEQVLRQACERVGLPVLGVVARDAD 181 Query 188 LELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHP---PWDPVI 244 L +P+R+LGL+ A E A +V A+ V +D+ A++ A ++A P PW Sbjct 182 LSVPSRHLGLIPAAERQHEAVESVAAIVGKVGAALDIPAIVRIA-NEARPPVVEPWSATT 240 Query 245 AVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVL 301 AVG R T+A+A G AFTFGYAEHAE+LRAAGAEVV FDPL + LP GTDAVV+ Sbjct 241 AVGVDRPAGRARPTIAVAQGAAFTFGYAEHAELLRAAGAEVVGFDPLRDRLPAGTDAVVI 300 Query 302 PGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSAR 361 GGFPE +L+AN +R + AAG PVHAECAGLLYL+S LDG PM G + G+ Sbjct 301 GGGFPEAHAEDLAANADLRSDLRAHVAAGRPVHAECAGLLYLLSTLDGVPMVGALDGTGT 360 Query 362 FTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDG 421 F L LGYRDAVA+ DS +Y GERV GHEFHR+ V A S PAW ++ V DG Sbjct 361 FGPRLTLGYRDAVALADSTMYRAGERVTGHEFHRSTVHLAGSASPAWAWRADGASAV-DG 419 Query 422 AVHSGVHASYLHTHPAATPGAVARFV 447 VH+GVHASYLH HPA P AVARFV Sbjct 420 VVHAGVHASYLHVHPAGRPRAVARFV 445 >gi|343926755|ref|ZP_08766252.1| cobyrinic acid A,C-diamide synthase [Gordonia alkanivorans NBRC 16433] gi|343763354|dbj|GAA13178.1| cobyrinic acid A,C-diamide synthase [Gordonia alkanivorans NBRC 16433] Length=486 Score = 474 bits (1221), Expect = 9e-132, Method: Compositional matrix adjust. Identities = 265/465 (57%), Positives = 320/465 (69%), Gaps = 16/465 (3%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 AV +AAP+SGSGKTT+ TGLIGALR AGH VAPFKVGPD+IDPGYHA+AAGRPGRNLDP Sbjct 10 AVVIAAPSSGSGKTTVTTGLIGALRAAGHRVAPFKVGPDYIDPGYHAVAAGRPGRNLDPN 69 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAA------GSTAHVAALLG 118 LVGE+LI PL+AHG AGADIAV+EGV+GLFDGRI A GSTAHVA+++G Sbjct 70 LVGEKLIAPLFAHGSAGADIAVVEGVMGLFDGRITSDDPDAADTDALGIGSTAHVASIIG 129 Query 119 APVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAV 178 APV+LVVDA G S S+AA+LHGF ++DT+ IAGVILNRVGS RHE VLRQAC + GV V Sbjct 130 APVVLVVDAGGHSQSLAAVLHGFLSYDTSVHIAGVILNRVGSPRHEMVLRQACARVGVPV 189 Query 179 LGAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHP 238 G + R L +P+R+LGL+ A E A AV +MT + +DL A++A A Q P Sbjct 190 FGVLRRDPSLTVPSRHLGLIPAAERSADAVAAVASMTDHLRDALDLPAIVAAA-RQRRIP 248 Query 239 ---PWDPVIAVG---NTARQPAT---VAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS 289 PW A+ + A P++ +A+A G AFTFGYAEH EMLRAAGAEVV FDPL Sbjct 249 DAAPWSAAEALAPYVDGAPAPSSRPVIAVAGGAAFTFGYAEHTEMLRAAGAEVVAFDPLC 308 Query 290 ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDG 349 + LP T VV+ GGFPE+ EL AN +R + AAAG P+HAECAGL+YL LD Sbjct 309 DRLPPDTAGVVIGGGFPEEHAEELGANHELRADLRAHAAAGRPIHAECAGLVYLADRLDN 368 Query 350 HPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWV 409 PM GV+ + F L LGYRDAVA+ DS L+ GERV GHEFHR+ V D+ PAW Sbjct 369 RPMSGVLDIAGSFGPTLTLGYRDAVALGDSVLFRAGERVTGHEFHRSTVHVGDASTPAWA 428 Query 410 YQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHAACNT 454 ++ + DG V VHASYLH HPAA P A+ RFV+ ++ Sbjct 429 WRDVEGRPATDGVVTDAVHASYLHVHPAAIPEALNRFVSRVGSSS 473 >gi|334697120|gb|AEG81917.1| Cobyrinic acid a,c-diamide synthase [Corynebacterium ulcerans 809] Length=457 Score = 457 bits (1176), Expect = 2e-126, Method: Compositional matrix adjust. Identities = 250/453 (56%), Positives = 311/453 (69%), Gaps = 12/453 (2%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V V +AA +SGSGKTTIATGL+ AL Q VAPFKVGPD+ID GYH +AAGR GRNLD Sbjct 5 VPGVVIAATSSGSGKTTIATGLMAALAQR-MVVAPFKVGPDYIDTGYHGMAAGRVGRNLD 63 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGG---APAAGSTAHVAALLGA 119 V+ G +GPLYAHG GADIAV+EGV+GLFDGRI A A GSTA +AA LG Sbjct 64 SVMCGRSALGPLYAHGAQGADIAVVEGVMGLFDGRITEGSNTADARAQGSTAEIAAELGL 123 Query 120 PVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVL 179 PVILVVD RG S SV A++HGF+T D A R+AGVILN+VG+ RH V R++ + GV VL Sbjct 124 PVILVVDVRGMSQSVGAVVHGFATADDAVRVAGVILNKVGTDRHAAVCRESVEAVGVPVL 183 Query 180 GAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPP 239 GAIPR + E+P+R+LGLVT+ E +AR V M A+V +HVDL AVI+ A Sbjct 184 GAIPRVDDAEVPSRHLGLVTSTEL-LQARSVVAEMAAMVEQHVDLDAVISLARCTFTGAA 242 Query 240 WDPVIAVGNTA---RQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGT 296 WDP++AVG+ R P +A+A G AF+F YAEH E+L AAGAEV+ FDPL + LP+ Sbjct 243 WDPMVAVGDRVGGFRSP-RIALAGGPAFSFTYAEHVELLEAAGAEVLAFDPLIDDLPD-C 300 Query 297 DAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVV 356 D +++PGGFPE++ L+ ++R I G PVHAECAGLL+L+ LDGH M GV+ Sbjct 301 DGLIIPGGFPEEYCEVLAKRKDLQRSIVSRIEQGMPVHAECAGLLWLLDTLDGHRMLGVI 360 Query 357 AGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADS--YQPAWVYQGQD 414 + A + L LGYRDAVA+ DS +Y GERV GHEFH TA+ AD+ ++ AW ++ D Sbjct 361 SAQAAMGRRLTLGYRDAVALSDSVMYRAGERVTGHEFHHTALVKADASGWESAWGWRTWD 420 Query 415 VDDVRDGAVHSGVHASYLHTHPAATPGAVARFV 447 R+G V VHASYLH HPA+ P AV RFV Sbjct 421 GVAAREGFVRGNVHASYLHVHPASVPRAVRRFV 453 >gi|213964519|ref|ZP_03392719.1| cobyrinic Acid a,c-diamide synthase [Corynebacterium amycolatum SK46] gi|213952712|gb|EEB64094.1| cobyrinic Acid a,c-diamide synthase [Corynebacterium amycolatum SK46] Length=458 Score = 455 bits (1171), Expect = 7e-126, Method: Compositional matrix adjust. Identities = 244/461 (53%), Positives = 315/461 (69%), Gaps = 14/461 (3%) Query 1 MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRN 60 M + +AA ASG+GKTTI+TGL+ AL + H VAPFKVGPD+IDPGYH +AAGRPGRN Sbjct 1 MVAPGIVIAATASGTGKTTISTGLMRALSRR-HAVAPFKVGPDYIDPGYHGVAAGRPGRN 59 Query 61 LDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAP 120 LD + +IGPLYAHG A +DIAV+EGV+GLFDGRIG GSTA +A+LLG P Sbjct 60 LDSFMCSPEMIGPLYAHGAADSDIAVVEGVMGLFDGRIGD-DPLSVVGSTAEIASLLGLP 118 Query 121 VILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLG 180 V+LV+DAR S S AA++HGFST T R++GVI+N+VGS RH ++ ++ + GV VLG Sbjct 119 VVLVIDARHMSQSAAAVVHGFSTLRTDVRVSGVIINQVGSPRHADIITRSVEAMGVEVLG 178 Query 181 AIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPW 240 AIPR ++E+P+R+LGLVTAVE G + +++M +V ++D+ +I A PW Sbjct 179 AIPRVTDIEVPSRHLGLVTAVEQGEQLETVIESMANLVETYIDIDRIIQLARQPYPAEPW 238 Query 241 DPVIAVGNTARQ-PATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAV 299 DP V A Q VA+AAG AF+F YAEH E+LRAAGAEVV+FDPL + LPE + Sbjct 239 DPARFVAPLATQRRVRVAVAAGPAFSFTYAEHRELLRAAGAEVVDFDPLVDELPE-AEGY 297 Query 300 VLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGS 359 ++PGGFPE+ LS D +RR + + A GA +H ECAGLL+L+ +L G MCG++ G Sbjct 298 IVPGGFPEEHADALSVRDDIRRDLRQAADDGALIHGECAGLLWLLEDLGGRRMCGIIPGR 357 Query 360 ARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVT-------FADSYQPAWVYQG 412 A + LKLGYR+AVA+ DSAL VG RV GHEFH+TA+T A +QPAW ++G Sbjct 358 AHMAR-LKLGYREAVALTDSALCPVGTRVRGHEFHKTALTDDTASVAAAAGWQPAWGWRG 416 Query 413 QDVDDVRDGAVHSG--VHASYLHTHPAATPGAVARFVAHAA 451 + VRDG V +HA YLH HPA PG V+RFVA A Sbjct 417 YQGETVRDGFVSESGRIHAGYLHVHPAGAPGNVSRFVASCA 457 >gi|337291006|ref|YP_004630027.1| Cobyrinic acid a,c-diamide synthase [Corynebacterium ulcerans BR-AD22] gi|334699312|gb|AEG84108.1| Cobyrinic acid a,c-diamide synthase [Corynebacterium ulcerans BR-AD22] Length=457 Score = 454 bits (1168), Expect = 1e-125, Method: Compositional matrix adjust. Identities = 249/453 (55%), Positives = 310/453 (69%), Gaps = 12/453 (2%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V V +AA +SGSGKTTIATGL+ AL Q VAPFKVGPD+ID GYH +AAGR GRNLD Sbjct 5 VPGVVIAATSSGSGKTTIATGLMAALAQR-MVVAPFKVGPDYIDTGYHGMAAGRVGRNLD 63 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGG---APAAGSTAHVAALLGA 119 V+ G +GPLYAHG GADIAV+EGV+GLFDGRI A A GSTA +AA LG Sbjct 64 SVMCGRSALGPLYAHGAQGADIAVVEGVMGLFDGRITEGSNTADARAQGSTAEIAAELGL 123 Query 120 PVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVL 179 PVILVVD RG S SV A++HGF+T D A R+AGVILN+VG+ RH V R++ + GV VL Sbjct 124 PVILVVDVRGMSQSVGAVVHGFATADDAVRVAGVILNKVGTDRHAAVCRESVEAVGVPVL 183 Query 180 GAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPP 239 GAIPR + E+P+R+LGLVT+ E +AR V M A+V +HVDL AVI+ A Sbjct 184 GAIPRVDDAEVPSRHLGLVTSTEL-LQARSVVAEMAAMVEQHVDLDAVISLARCTFTGAA 242 Query 240 WDPVIAVGNTA---RQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGT 296 WDP++AVG+ R P +A+A G AF+F YAEH E+L AAGAEV+ FDPL + LP+ Sbjct 243 WDPMVAVGDRVGGFRSP-RIALAGGPAFSFTYAEHVELLEAAGAEVLAFDPLIDDLPD-C 300 Query 297 DAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVV 356 D +++PGGFPE++ L+ ++ I G PVHAECAGLL+L+ LDGH M GV+ Sbjct 301 DGLIIPGGFPEEYCEVLAKRKDLQCSIVSRIEQGMPVHAECAGLLWLLDTLDGHRMLGVI 360 Query 357 AGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADS--YQPAWVYQGQD 414 + A + L LGYRDAVA+ DS +Y GERV GHEFH TA+ AD+ ++ AW ++ D Sbjct 361 SAQAAMGRRLTLGYRDAVALSDSVMYRAGERVTGHEFHHTALVKADASGWESAWGWRTWD 420 Query 415 VDDVRDGAVHSGVHASYLHTHPAATPGAVARFV 447 R+G V VHASYLH HPA+ P AV RFV Sbjct 421 GVTAREGFVRGNVHASYLHVHPASVPRAVRRFV 453 >gi|325001453|ref|ZP_08122565.1| cobyrinic acid a,c-diamide synthase [Pseudonocardia sp. P1] Length=448 Score = 447 bits (1150), Expect = 2e-123, Method: Compositional matrix adjust. Identities = 271/451 (61%), Positives = 319/451 (71%), Gaps = 17/451 (3%) Query 5 AVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPV 64 AV VAAP+SGSGKTT++TGL+ AL + G VAPFKVGPD+IDPGYH LAAGRPGRNLD V Sbjct 7 AVVVAAPSSGSGKTTVSTGLMAALSRRGTRVAPFKVGPDYIDPGYHTLAAGRPGRNLDVV 66 Query 65 LVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILV 124 L G + PL HG AGAD+AV+EGV+GLFDGRI A AGSTA VA+ LGAPV+LV Sbjct 67 LQGTHRLAPLARHGAAGADVAVVEGVMGLFDGRI-----ADGAGSTAQVASALGAPVVLV 121 Query 125 VDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPR 184 VD RGQS S+AALLHGF +FD + ++AGVILNRVGS RH +V R A D+ G+ VLGA+PR Sbjct 122 VDVRGQSRSLAALLHGFRSFDPSVQVAGVILNRVGSDRHTEVCRAAADEVGLPVLGAVPR 181 Query 185 TAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVI 244 AEL +P+R+LGLVTA E+G A AV AM +VA HVDL AV+A A P WDP Sbjct 182 RAELAVPSRHLGLVTAAEHGSAATAAVDAMAELVAAHVDLDAVLALARPLPDGPAWDPAA 241 Query 245 A------VGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSE-TLPEGTD 297 V + +P VA+A G AF FGYAEHAE+L AAGAEV DPL + +LP+ T Sbjct 242 ETAAAGPVPDAGERP-VVALAGGPAFGFGYAEHAELLAAAGAEVAVVDPLRDPSLPDRTA 300 Query 298 AVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVA 357 A+VLPGGFPE+ L N ++R + LAA+GAPVHAEC GLLYL +LDG PMCGV+ Sbjct 301 ALVLPGGFPEEHVGALGENASLRSGVARLAASGAPVHAECGGLLYLCRDLDGTPMCGVLD 360 Query 358 GSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDD 417 SA T L LGYRDAVAV SA + G RV HEFHR AVT PAWV++G + Sbjct 361 ASAAMTPRLTLGYRDAVAVSGSAPFPAGARVGAHEFHRCAVTPRAGAAPAWVWRGGE--- 417 Query 418 VRDGAVHSGVHASYLHTHPAATPGAVARFVA 448 +G V GVHAS+LHTHPA P AVARFVA Sbjct 418 -PEGYVVDGVHASFLHTHPAGVPEAVARFVA 447 >gi|300858709|ref|YP_003783692.1| cobyrinic acid a,c-diamide synthase [Corynebacterium pseudotuberculosis FRC41] gi|300686163|gb|ADK29085.1| Cobyrinic acid a,c-diamide synthase [Corynebacterium pseudotuberculosis FRC41] gi|302206419|gb|ADL10761.1| Cobyrinic acid A,C-diamide synthase [Corynebacterium pseudotuberculosis C231] gi|302330975|gb|ADL21169.1| Cobyrinic acid A,C-diamide synthase [Corynebacterium pseudotuberculosis 1002] gi|308276662|gb|ADO26561.1| Cobyrinic acid a,c-diamide synthase [Corynebacterium pseudotuberculosis I19] gi|341825102|gb|AEK92623.1| Cobyrinic acid A,C-diamide synthase [Corynebacterium pseudotuberculosis PAT10] Length=457 Score = 445 bits (1144), Expect = 1e-122, Method: Compositional matrix adjust. Identities = 241/453 (54%), Positives = 305/453 (68%), Gaps = 12/453 (2%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V V +AA +SGSGKTTIATGLI AL Q VAPFKVGPD+ID GYH +AAGR GRNLD Sbjct 5 VPGVVIAATSSGSGKTTIATGLIAALAQR-MVVAPFKVGPDYIDTGYHGMAAGRVGRNLD 63 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGG---APAAGSTAHVAALLGA 119 V+ G +GPLYAHG GADI+V+EGV+GLFDGRI A A GSTA +AA LG Sbjct 64 SVMCGRAALGPLYAHGAQGADISVVEGVMGLFDGRITEGANTADARAQGSTAEIAAELGL 123 Query 120 PVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVL 179 PVILVVD RG S SV A++ GF+T D A R+AGVILN+VG+ RH V R++ + G+ VL Sbjct 124 PVILVVDVRGMSQSVGAVVRGFATADDAVRVAGVILNKVGTDRHAAVCRESVEAVGIPVL 183 Query 180 GAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPP 239 GAIPR + E+P+R+LGLVT+ E +AR + M A+V HVDL A+++ A Sbjct 184 GAIPRVDDAEVPSRHLGLVTSTELS-QARSVISEMAAMVEHHVDLDALVSLARCTFTGAA 242 Query 240 WDPVIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGT 296 WDP VG ++ R P +A+A G AF+F YAEH E+L AAGA V+ FDPL + LPE Sbjct 243 WDPRAVVGGHLSSERSP-RIALAGGPAFSFTYAEHVELLEAAGARVLAFDPLIDDLPE-C 300 Query 297 DAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVV 356 D +++PGGFPE++ L+ ++R I G PVHAECAGLL+L+ LDGH M G++ Sbjct 301 DGLIIPGGFPEEYCEVLANRKDLQRSIVNRIDQGMPVHAECAGLLWLLDALDGHRMLGII 360 Query 357 AGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADS--YQPAWVYQGQD 414 A + L LGYR+AVA+ DS +Y GERV GHEFH TA+T D+ ++ AW ++ D Sbjct 361 TAQAAMKRRLTLGYREAVALSDSVMYRAGERVTGHEFHHTALTKDDALGWESAWGWRTWD 420 Query 415 VDDVRDGAVHSGVHASYLHTHPAATPGAVARFV 447 R+G V +HASYLH HPA+ P AV RFV Sbjct 421 GAAAREGFVRGNIHASYLHVHPASVPRAVRRFV 453 >gi|239986817|ref|ZP_04707481.1| cobyrinic acid a,c-diamide synthase [Streptomyces roseosporus NRRL 11379] Length=453 Score = 443 bits (1140), Expect = 3e-122, Method: Compositional matrix adjust. Identities = 251/451 (56%), Positives = 302/451 (67%), Gaps = 12/451 (2%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V + +AAPAS SGKTT+ATGL+ A G V+P KVGPD+IDPGYH+LA GRPGRNLD Sbjct 4 VPRLVIAAPASNSGKTTVATGLMAAFAARGLAVSPHKVGPDYIDPGYHSLATGRPGRNLD 63 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 + G L+ PL+AHG AG D+AV+EGV+GL+DG A G STA VA LL APV+ Sbjct 64 AYMCGTDLVAPLFAHGSAGCDLAVVEGVMGLYDG----ASGQGELASTAQVAKLLKAPVV 119 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDA QS SVAAL+HGF+++D RI GVILN+V S RHE +LR A D++G+ VLG I Sbjct 120 LVVDASSQSRSVAALVHGFASWDPEVRIGGVILNKVASDRHEALLRDALDESGLPVLGVI 179 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAA--HPPW 240 R ++ P+R+LGLV E A AV+AM V DL A++A A + A PW Sbjct 180 RRAPQVATPSRHLGLVPVAERQSDAVDAVRAMGERVRAGCDLDALLALARTAPALADEPW 239 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPL-SETLPEGTDAV 299 P A G +P VA+A G AFTF YAEHAE+L AAGAEVV FDPL E LP GT + Sbjct 240 APAYAPGPGGEKP-VVAVAGGAAFTFAYAEHAELLTAAGAEVVTFDPLRDEKLPVGTAGL 298 Query 300 VLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGS 359 V+ GGFPE + ELSAN+ +RR + ELA +GAPV AECAGLLYL ELDG PMCGV+ Sbjct 299 VIGGGFPEMYAPELSANEPLRRAVTELALSGAPVAAECAGLLYLARELDGKPMCGVLDAE 358 Query 360 ARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVR 419 AR ++ L LGYR AVAV DS L + G R+ GHEFHRT + A PAW G + R Sbjct 359 ARMSERLTLGYRQAVAVSDSPLAAAGTRMRGHEFHRTVLEPAAGTTPAW---GMHQPERR 415 Query 420 -DGAVHSGVHASYLHTHPAATPGAVARFVAH 449 +G V GVHASYLHTH AA+P RFV H Sbjct 416 VEGYVQRGVHASYLHTHWAASPEVARRFVEH 446 >gi|291443768|ref|ZP_06583158.1| cobyrinic acid a,c-diamide synthase [Streptomyces roseosporus NRRL 15998] gi|291346715|gb|EFE73619.1| cobyrinic acid a,c-diamide synthase [Streptomyces roseosporus NRRL 15998] Length=512 Score = 441 bits (1135), Expect = 9e-122, Method: Compositional matrix adjust. Identities = 251/451 (56%), Positives = 302/451 (67%), Gaps = 12/451 (2%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V + +AAPAS SGKTT+ATGL+ A G V+P KVGPD+IDPGYH+LA GRPGRNLD Sbjct 63 VPRLVIAAPASNSGKTTVATGLMAAFAARGLAVSPHKVGPDYIDPGYHSLATGRPGRNLD 122 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 + G L+ PL+AHG AG D+AV+EGV+GL+DG A G STA VA LL APV+ Sbjct 123 AYMCGTDLVAPLFAHGSAGCDLAVVEGVMGLYDG----ASGQGELASTAQVAKLLKAPVV 178 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDA QS SVAAL+HGF+++D RI GVILN+V S RHE +LR A D++G+ VLG I Sbjct 179 LVVDASSQSRSVAALVHGFASWDPEVRIGGVILNKVASDRHEALLRDALDESGLPVLGVI 238 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAA--HPPW 240 R ++ P+R+LGLV E A AV+AM V DL A++A A + A PW Sbjct 239 RRAPQVATPSRHLGLVPVAERQSDAVDAVRAMGERVRAGCDLDALLALARTAPALADEPW 298 Query 241 DPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPL-SETLPEGTDAV 299 P A G +P VA+A G AFTF YAEHAE+L AAGAEVV FDPL E LP GT + Sbjct 299 APAYAPGPGGEKP-VVAVAGGAAFTFAYAEHAELLTAAGAEVVTFDPLRDEKLPVGTAGL 357 Query 300 VLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGS 359 V+ GGFPE + ELSAN+ +RR + ELA +GAPV AECAGLLYL ELDG PMCGV+ Sbjct 358 VIGGGFPEMYAPELSANEPLRRAVTELALSGAPVAAECAGLLYLARELDGKPMCGVLDAE 417 Query 360 ARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVR 419 AR ++ L LGYR AVAV DS L + G R+ GHEFHRT + A PAW G + R Sbjct 418 ARMSERLTLGYRQAVAVSDSPLAAAGTRMRGHEFHRTVLEPAAGTTPAW---GMHQPERR 474 Query 420 -DGAVHSGVHASYLHTHPAATPGAVARFVAH 449 +G V GVHASYLHTH AA+P RFV H Sbjct 475 VEGYVQRGVHASYLHTHWAASPEVARRFVEH 505 >gi|326780098|ref|ZP_08239363.1| Cobyrinic acid A,C-diamide synthase [Streptomyces cf. griseus XylebKG-1] gi|326660431|gb|EGE45277.1| Cobyrinic acid A,C-diamide synthase [Streptomyces griseus XylebKG-1] Length=450 Score = 440 bits (1131), Expect = 3e-121, Method: Compositional matrix adjust. Identities = 250/448 (56%), Positives = 301/448 (68%), Gaps = 12/448 (2%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 + +AAPASGSGKTT+ATGL+ A G V+P KVGPD+IDPGYH+LA GRPGRNLD + Sbjct 7 LVIAAPASGSGKTTVATGLMAAFAARGLAVSPHKVGPDYIDPGYHSLATGRPGRNLDAYM 66 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVV 125 G L+ PL+AHG AG D+AV+EGV+GL+DG A G STA VA LL APV+LVV Sbjct 67 CGTELVAPLFAHGSAGCDLAVVEGVMGLYDG----ASGQGELASTAQVAKLLRAPVVLVV 122 Query 126 DARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRT 185 DA QS SVAAL+HGF+++D RI GVILN+V S RHE +LR A D++G+ VLG I R Sbjct 123 DASSQSRSVAALVHGFASWDPEVRIGGVILNKVASDRHEALLRDALDESGLPVLGVIRRA 182 Query 186 AELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAA--HPPWDPV 243 ++ P+R+LGLV E G A AV AM V DL A++A A + A PW+P Sbjct 183 PQVATPSRHLGLVPVAERGADAVDAVAAMGERVRAGCDLDALMALARTAPALADEPWEPA 242 Query 244 IAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPL-SETLPEGTDAVVLP 302 G +P VA+A G AFTF YAEHAE+L AAGA+VV FDPL E LP GT +V+ Sbjct 243 YTPGPGGEKP-VVAVAGGAAFTFAYAEHAELLTAAGADVVVFDPLRDEKLPAGTAGLVIG 301 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPE + ELSAN+ +RR + ELA +GAPV AECAGLLYL ELDG PMCGV+ AR Sbjct 302 GGFPEMYAPELSANEPLRRAVTELALSGAPVAAECAGLLYLARELDGKPMCGVLDAEARM 361 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVR-DG 421 ++ L LGYR AVAV DSAL G R+ GHEFHRT + PAW G + R +G Sbjct 362 SERLTLGYRQAVAVSDSALAVAGTRMRGHEFHRTVLEPGAGTTPAW---GMHQPERRVEG 418 Query 422 AVHSGVHASYLHTHPAATPGAVARFVAH 449 V GVHASYLHTH AA+P RFV H Sbjct 419 YVQRGVHASYLHTHWAASPEVARRFVGH 446 >gi|182439434|ref|YP_001827153.1| cobyrinic acid a,c-diamide synthase [Streptomyces griseus subsp. griseus NBRC 13350] gi|178467950|dbj|BAG22470.1| putative cobyrinic acid a,c-diamide synthase [Streptomyces griseus subsp. griseus NBRC 13350] Length=450 Score = 439 bits (1130), Expect = 4e-121, Method: Compositional matrix adjust. Identities = 250/448 (56%), Positives = 301/448 (68%), Gaps = 12/448 (2%) Query 6 VAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVL 65 + +AAPASGSGKTT+ATGL+ A G V+P KVGPD+IDPGYH+LA GRPGRNLD + Sbjct 7 LVIAAPASGSGKTTVATGLMAAFAARGLAVSPHKVGPDYIDPGYHSLATGRPGRNLDAYM 66 Query 66 VGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVV 125 G L+ PL+AHG AG D+AV+EGV+GL+DG A G STA VA LL APV+LVV Sbjct 67 CGTELVAPLFAHGSAGCDLAVVEGVMGLYDG----ASGQGDLASTAQVAKLLRAPVVLVV 122 Query 126 DARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRT 185 DA QS SVAAL+HGF+++D RI GVILN+V S RHE +LR A D++G+ VLG I R Sbjct 123 DASSQSRSVAALVHGFASWDPEVRIGGVILNKVASDRHEALLRDALDESGLPVLGVIRRA 182 Query 186 AELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAA--HPPWDPV 243 ++ P+R+LGLV E G A AV AM V DL A++A A + A PW+P Sbjct 183 PQVATPSRHLGLVPVAERGADAVDAVAAMGERVRAGCDLDALMALARTAPALADEPWEPA 242 Query 244 IAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPL-SETLPEGTDAVVLP 302 G +P VA+A G AFTF YAEHAE+L AAGA+VV FDPL E LP GT +V+ Sbjct 243 YTPGPGGEKP-VVAVAGGAAFTFAYAEHAELLTAAGADVVVFDPLRDEKLPAGTAGLVIG 301 Query 303 GGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARF 362 GGFPE + ELSAN+ +RR + ELA +GAPV AECAGLLYL ELDG PMCGV+ AR Sbjct 302 GGFPEMYAPELSANEPLRRAVTELALSGAPVAAECAGLLYLARELDGKPMCGVLDAEARM 361 Query 363 TQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVR-DG 421 ++ L LGYR AVAV DSAL G R+ GHEFHRT + PAW G + R +G Sbjct 362 SERLTLGYRQAVAVSDSALAVAGTRMRGHEFHRTVLEPGAGTTPAW---GMHQPERRVEG 418 Query 422 AVHSGVHASYLHTHPAATPGAVARFVAH 449 V GVHASYLHTH AA+P RFV H Sbjct 419 YVQRGVHASYLHTHWAASPEVARRFVGH 446 >gi|289772428|ref|ZP_06531806.1| cobyrinic acid a,c-diamide synthase [Streptomyces lividans TK24] gi|289702627|gb|EFD70056.1| cobyrinic acid a,c-diamide synthase [Streptomyces lividans TK24] Length=486 Score = 437 bits (1125), Expect = 2e-120, Method: Compositional matrix adjust. Identities = 264/486 (55%), Positives = 309/486 (64%), Gaps = 44/486 (9%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V + +AAP+SGSGKTT+ATGL+ AL G V+P KVGPD+IDPGYHALA GR GRNLD Sbjct 10 VPRLVIAAPSSGSGKTTVATGLMAALTARGLAVSPHKVGPDYIDPGYHALATGRVGRNLD 69 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 L G L+GPL HG G DIAV+EGV+GL+DG A G STA VA LL APV+ Sbjct 70 AYLCGPELVGPLLLHGARGCDIAVVEGVMGLYDG----AAGEGELASTAQVAKLLRAPVV 125 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDA QS SVAAL+HGF ++D RI GVILN+V S RHE +LR+A D GV VLG + Sbjct 126 LVVDASSQSRSVAALVHGFVSWDPEVRIGGVILNKVASDRHEALLREAVDSVGVPVLGVL 185 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAV---------IACAGS 233 R A +E P+R+LGLV E G A AV AM A VA DL A+ ++CA Sbjct 186 RRAAPVETPSRHLGLVPVAERGSDAVDAVAAMGARVADGCDLEALAGLARSAGALSCAAW 245 Query 234 QA------------------AHPPWDPVIAVGNTARQPAT-----VAIAAGRAFTFGYAE 270 A A PP DP++ G Q VA+A+G AFTF YAE Sbjct 246 DAGEALVSSPPPPLPVPSPGAAPP-DPLVRPGRPRPQAPDGLRRRVAMASGAAFTFSYAE 304 Query 271 HAEMLRAAGAEVVEFDPL-SETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAA 329 H E+L AAGAEVV FDPL E LPEGT +V+ GGFPE + AELSAN+ +R+ + ELA + Sbjct 305 HTELLAAAGAEVVTFDPLRDEELPEGTQGLVIGGGFPEVYAAELSANEGLRKSVAELAFS 364 Query 330 GAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV 389 GAPV AECAGLLYL ELDG PMCGV+ +AR ++ L LGYRDAVAV DSAL G R+ Sbjct 365 GAPVAAECAGLLYLCRELDGLPMCGVLDAAARMSERLTLGYRDAVAVSDSALAVAGTRMR 424 Query 390 GHEFHRTAVTFADSYQPAWVYQGQDVDDVR-DGAVHSGVHASYLHTHPAATPGAVARFVA 448 GHEFHRTAV PAW G + R +G V GVHASYLHTH AA PG RFV Sbjct 425 GHEFHRTAVEPGAGAAPAW---GMRAPERRVEGFVERGVHASYLHTHWAAEPGVARRFVE 481 Query 449 HAACNT 454 C T Sbjct 482 R--CRT 485 >gi|21220341|ref|NP_626120.1| cobyrinic acid a,c-diamide synthase [Streptomyces coelicolor A3(2)] gi|30172972|sp|Q9RJ16.1|COBB_STRCO RecName: Full=Cobyrinic acid A,C-diamide synthase gi|6117895|emb|CAB59468.1| cobyrinic acid A,C-diamide synthase [Streptomyces coelicolor A3(2)] Length=486 Score = 437 bits (1123), Expect = 2e-120, Method: Compositional matrix adjust. Identities = 262/486 (54%), Positives = 309/486 (64%), Gaps = 44/486 (9%) Query 3 VSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLD 62 V + +AAP+SGSGKTT+ATGL+ AL G V+P KVGPD+IDPGYHALA GR GRNLD Sbjct 10 VPRLVIAAPSSGSGKTTVATGLMAALTARGLAVSPHKVGPDYIDPGYHALATGRVGRNLD 69 Query 63 PVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVI 122 L G L+GPL+ HG G DIAV+EGV+GL+DG A G STA VA LL APV+ Sbjct 70 AYLCGPELVGPLFLHGARGCDIAVVEGVMGLYDG----AAGEGELASTAQVAKLLRAPVV 125 Query 123 LVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAI 182 LVVDA QS SVAAL+HGF ++D RI GVILN+V S RHE +LR+A D GV VLG + Sbjct 126 LVVDASSQSRSVAALVHGFVSWDPEVRIGGVILNKVASDRHEALLREAVDSVGVPVLGVL 185 Query 183 PRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVI---------ACAGS 233 R A +E P+R+LGLV E G A AV AM A VA DL A++ +CA Sbjct 186 RRAAPVETPSRHLGLVPVAERGSDAVDAVAAMGARVADGCDLEALVGLARSTGALSCAAW 245 Query 234 QA------------------AHPPWDPVIAVGNTARQPAT-----VAIAAGRAFTFGYAE 270 A A PP DP++ G Q VA+A+G AFTF YAE Sbjct 246 DAGEALVSSPPPPLPVPSPGAAPP-DPLVRPGRPRPQAPDGLRRRVAMASGAAFTFSYAE 304 Query 271 HAEMLRAAGAEVVEFDPL-SETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAA 329 H E+L AAGAEVV FDPL E LPEGT +V+ GGFPE + +ELSAN+ +R+ + ELA + Sbjct 305 HTELLAAAGAEVVTFDPLRDEELPEGTQGLVIGGGFPEVYASELSANEGLRKSVAELAFS 364 Query 330 GAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV 389 GAPV AECAGLLYL ELDG PMCGV+ +AR ++ L LGYRDAVAV DSAL G R+ Sbjct 365 GAPVAAECAGLLYLCRELDGLPMCGVLDAAARMSKRLTLGYRDAVAVSDSALAVAGTRMR 424 Query 390 GHEFHRTAVTFADSYQPAWVYQGQDVDDVR-DGAVHSGVHASYLHTHPAATPGAVARFVA 448 GHEFHRT V PAW G + R +G V GVHASYLHTH AA PG RFV Sbjct 425 GHEFHRTVVEPGAGAAPAW---GMRAPERRVEGFVERGVHASYLHTHWAAEPGVARRFVE 481 Query 449 HAACNT 454 C T Sbjct 482 R--CRT 485 >gi|161598673|ref|NP_939836.2| cobyrinic acid a,c-diamide synthase [Corynebacterium diphtheriae NCTC 13129] Length=459 Score = 435 bits (1119), Expect = 8e-120, Method: Compositional matrix adjust. Identities = 243/451 (54%), Positives = 298/451 (67%), Gaps = 16/451 (3%) Query 8 VAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVG 67 +AA +SGSGKTTIATG++ AL + VAPFKVGPD+IDPGYH +AAG GRNLD V+ G Sbjct 9 IAATSSGSGKTTIATGMMAALSRK-MRVAPFKVGPDYIDPGYHGMAAGHQGRNLDSVMCG 67 Query 68 ERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGP---AGGAPAAGSTAHVAALLGAPVILV 124 LIGPLYAHG A ADIAV+EGV+GLFDGRI A A GS+A +AA LG PV+LV Sbjct 68 IDLIGPLYAHGSANADIAVVEGVMGLFDGRIAQGQNTADAQAQGSSAEIAATLGLPVVLV 127 Query 125 VDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPR 184 VD RG S SV A++ GF+T D RIAGVILN+VG+ RH +V R+A + GV VLGAIPR Sbjct 128 VDVRGMSQSVGAVVRGFATADPHVRIAGVILNKVGTDRHAEVCREAVEAVGVRVLGAIPR 187 Query 185 TAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVI 244 E+P+R+LGL+T+VE T +V HVDL A+I A P WDP + Sbjct 188 VDHAEVPSRHLGLITSVELDAAEDAVAAMAT-MVEEHVDLNALIELADCAYNGPAWDPAL 246 Query 245 AVGNTARQ----PATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVV 300 A+G + + +A+A G AF+F YAEH EML AAGA VV FDPLSE LP+ D ++ Sbjct 247 AMGMSDAEALDNKPVIALAGGPAFSFTYAEHVEMLSAAGATVVAFDPLSEQLPQ-CDGLI 305 Query 301 LPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSA 360 +PGGFPE+ L +++Q+ ++ A G PVHAECAGLL+L+S LDG PM V+ Sbjct 306 IPGGFPEEHCDVLEQRADLKQQVCDVIAQGIPVHAECAGLLWLLSTLDGRPMLDVIPTHG 365 Query 361 RFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQP----AWVYQGQDVD 416 + L LGYRDAV V DS +Y GERV GHEFH TA+ ADS P AW ++ D Sbjct 366 AMGRRLTLGYRDAVVVHDSVIYRAGERVTGHEFHHTAI--ADSVVPGWDSAWGWRAWDGS 423 Query 417 DVRDGAVHSGVHASYLHTHPAATPGAVARFV 447 +G V VHASYLH HPAA P AV RFV Sbjct 424 PKVEGFVSGNVHASYLHVHPAAVPAAVRRFV 454 Lambda K H 0.320 0.135 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 955199590996 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40