BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2946c Length=1616 Score E Sequences producing significant alignments: (Bits) Value gi|15610083|ref|NP_217462.1| polyketide synthase PKS1 [Mycobacte... 3160 0.0 gi|339295785|gb|AEJ47896.1| polyketide synthase PKS1 [Mycobacter... 3159 0.0 gi|289746746|ref|ZP_06506124.1| polyketide synthase PKS1 [Mycoba... 3158 0.0 gi|289553264|ref|ZP_06442474.1| LOW QUALITY PROTEIN: polyketide ... 3157 0.0 gi|167970038|ref|ZP_02552315.1| putative polyketide synthase pks... 3157 0.0 gi|15842494|ref|NP_337531.1| polyketide synthase [Mycobacterium ... 3157 0.0 gi|289575652|ref|ZP_06455879.1| polyketide synthase pks1 [Mycoba... 3155 0.0 gi|294993968|ref|ZP_06799659.1| putative polyketide synthase [My... 3153 0.0 gi|340627935|ref|YP_004746387.1| putative polyketide synthase PK... 3152 0.0 gi|31794123|ref|NP_856616.1| polyketide synthase PKS1 [Mycobacte... 3151 0.0 gi|289755061|ref|ZP_06514439.1| polyketide synthase pks1 [Mycoba... 2893 0.0 gi|15826966|ref|NP_301229.1| polyketide synthase [Mycobacterium ... 2576 0.0 gi|240171787|ref|ZP_04750446.1| putative polyketide synthase [My... 2450 0.0 gi|183981775|ref|YP_001850066.1| polyketide synthase Pks15/1 [My... 2405 0.0 gi|118617583|ref|YP_905915.1| polyketide synthase Pks15/1 [Mycob... 2396 0.0 gi|289751620|ref|ZP_06510998.1| polyketide synthase pks1 [Mycoba... 1959 0.0 gi|183983098|ref|YP_001851389.1| polyketide synthase and peptide... 1828 0.0 gi|254552020|ref|ZP_05142467.1| polyketide synthase pks1 [Mycoba... 1777 0.0 gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules ... 1699 0.0 gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 ... 1685 0.0 gi|560507|gb|AAA50928.1| pks002c [Mycobacterium tuberculosis] 1682 0.0 gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycoba... 1679 0.0 gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobact... 1670 0.0 gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 [Mycob... 1668 0.0 gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Myc... 1666 0.0 gi|289554169|ref|ZP_06443379.1| polyketide synthase Pks12 [Mycob... 1663 0.0 gi|339298599|gb|AEJ50709.1| polyketide synthase Pks12 [Mycobacte... 1662 0.0 gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933... 1662 0.0 gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacteri... 1662 0.0 gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085... 1662 0.0 gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_1100... 1662 0.0 gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_1090... 1662 0.0 gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 ... 1662 0.0 gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium ... 1662 0.0 gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycob... 1661 0.0 gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycob... 1661 0.0 gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Myco... 1660 0.0 gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobact... 1657 0.0 gi|340627059|ref|YP_004745511.1| putative polyketide synthase pk... 1657 0.0 gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12... 1654 0.0 gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules ... 1641 0.0 gi|240170497|ref|ZP_04749156.1| polyketide synthase, Pks12 [Myco... 1607 0.0 gi|41407894|ref|NP_960730.1| Pks12 [Mycobacterium avium subsp. p... 1601 0.0 gi|183983097|ref|YP_001851388.1| polyketide synthase PKS [Mycoba... 1600 0.0 gi|118463709|ref|YP_881643.1| erythronolide synthase, modules 3 ... 1599 0.0 gi|254822171|ref|ZP_05227172.1| erythronolide synthase, modules ... 1595 0.0 gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Myco... 1588 0.0 gi|183980137|ref|YP_001848428.1| polyketide synthase PKS [Mycoba... 1580 0.0 gi|296164561|ref|ZP_06847131.1| erythronolide synthase, modules ... 1573 0.0 gi|342859764|ref|ZP_08716417.1| erythronolide synthase, modules ... 1571 0.0 >gi|15610083|ref|NP_217462.1| polyketide synthase PKS1 [Mycobacterium tuberculosis H37Rv] gi|148662793|ref|YP_001284316.1| putative polyketide synthase Pks1 [Mycobacterium tuberculosis H37Ra] gi|148824135|ref|YP_001288889.1| polyketide synthase pks1 [Mycobacterium tuberculosis F11] 7 more sequence titles Length=1616 Score = 3160 bits (8193), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1615/1616 (99%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 +ISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 1 MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 >gi|339295785|gb|AEJ47896.1| polyketide synthase PKS1 [Mycobacterium tuberculosis CCDC5079] Length=1982 Score = 3159 bits (8189), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1615/1616 (99%), Positives = 1615/1616 (99%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 367 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 426 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 427 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 486 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 487 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 546 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 547 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 606 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQ G Sbjct 607 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQFG 666 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 667 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 726 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 727 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 786 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 787 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 846 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 847 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 906 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 907 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 966 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 967 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 1026 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 1027 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 1086 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 1087 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 1146 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 1147 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 1206 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 1207 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 1266 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 1267 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 1326 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 1327 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1386 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1387 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1446 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1447 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1506 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1507 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1566 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1567 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1626 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1627 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1686 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1687 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1746 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1747 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1806 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1807 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1866 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1867 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1926 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1927 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1982 >gi|289746746|ref|ZP_06506124.1| polyketide synthase PKS1 [Mycobacterium tuberculosis 02_1987] gi|298526415|ref|ZP_07013824.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] gi|289687274|gb|EFD54762.1| polyketide synthase PKS1 [Mycobacterium tuberculosis 02_1987] gi|298496209|gb|EFI31503.1| conserved hypothetical protein [Mycobacterium tuberculosis 94_M4241A] Length=2114 Score = 3158 bits (8188), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1616/1616 (100%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 499 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 559 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 619 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 679 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 739 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 799 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 859 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 918 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 919 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 978 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 979 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 1038 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 1039 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 1098 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 1099 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 1158 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 1159 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 1218 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 1219 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 1278 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 1279 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 1338 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 1339 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 1398 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 1399 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 1458 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 1459 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1518 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1519 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1578 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1579 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1638 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1639 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1698 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1699 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1758 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1759 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1818 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1819 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1878 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1879 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1938 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1939 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1998 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1999 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 2058 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 2059 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 2114 >gi|289553264|ref|ZP_06442474.1| LOW QUALITY PROTEIN: polyketide synthase PKS1 [Mycobacterium tuberculosis KZN 605] gi|289437896|gb|EFD20389.1| LOW QUALITY PROTEIN: polyketide synthase PKS1 [Mycobacterium tuberculosis KZN 605] Length=1631 Score = 3157 bits (8185), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1616/1616 (100%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 16 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 75 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 76 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 135 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 136 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 195 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 196 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 255 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 256 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 315 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 316 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 375 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 376 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 435 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 436 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 495 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 496 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 555 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 556 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 615 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 616 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 675 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 676 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 735 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 736 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 795 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 796 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 855 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 856 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 915 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 916 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 975 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 976 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1035 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1036 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1095 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1096 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1155 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1156 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1215 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1216 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1275 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1276 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1335 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1336 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1395 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1396 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1455 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1456 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1515 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1516 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1575 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1576 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1631 >gi|167970038|ref|ZP_02552315.1| putative polyketide synthase pks1 [Mycobacterium tuberculosis H37Ra] gi|313659897|ref|ZP_07816777.1| polyketide synthase pks1 [Mycobacterium tuberculosis KZN V2475] Length=1619 Score = 3157 bits (8184), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1616/1616 (100%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 4 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 63 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 64 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 123 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 124 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 183 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 184 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 243 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 244 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 303 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 304 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 363 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 364 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 423 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 424 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 483 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 484 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 543 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 544 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 603 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 604 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 663 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 664 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 723 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 724 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 783 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 784 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 843 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 844 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 903 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 904 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 963 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 964 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1023 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1024 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1083 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1084 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1143 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1144 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1203 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1204 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1263 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1264 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1323 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1324 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1383 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1384 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1443 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1444 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1503 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1504 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1563 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1564 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1619 >gi|15842494|ref|NP_337531.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|253797965|ref|YP_003030966.1| polyketide synthase pks1 [Mycobacterium tuberculosis KZN 1435] gi|254365583|ref|ZP_04981628.1| polyketide synthase pks1 [Mycobacterium tuberculosis str. Haarlem] 28 more sequence titles Length=1620 Score = 3157 bits (8184), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1616/1616 (100%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 5 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 64 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 65 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 124 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 125 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 184 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 185 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 244 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 245 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 304 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 305 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 364 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 365 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 424 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 425 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 484 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 485 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 544 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 545 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 604 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 605 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 664 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 665 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 724 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 725 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 784 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 785 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 844 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 845 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 904 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 905 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 964 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 965 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1024 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1025 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1084 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1085 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1144 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1145 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1204 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1205 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1264 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1265 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1324 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1325 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1384 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1385 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1444 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1445 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1504 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1505 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1564 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1565 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1620 >gi|289575652|ref|ZP_06455879.1| polyketide synthase pks1 [Mycobacterium tuberculosis K85] gi|339632954|ref|YP_004724596.1| polyketide synthase [Mycobacterium africanum GM041182] gi|289540083|gb|EFD44661.1| polyketide synthase pks1 [Mycobacterium tuberculosis K85] gi|339332310|emb|CCC28022.1| putative polyketide synthase [Mycobacterium africanum GM041182] Length=2112 Score = 3155 bits (8181), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1616/1616 (100%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 497 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 556 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 557 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 616 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 617 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 676 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 677 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 736 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 737 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 796 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 797 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 856 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 857 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 916 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 917 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 976 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 977 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 1036 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 1037 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 1096 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 1097 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 1156 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 1157 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 1216 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 1217 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 1276 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 1277 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 1336 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 1337 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 1396 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 1397 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 1456 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 1457 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1516 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1517 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1576 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1577 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1636 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1637 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1696 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1697 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1756 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1757 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1816 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1817 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1876 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1877 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1936 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1937 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1996 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1997 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 2056 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 2057 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 2112 >gi|294993968|ref|ZP_06799659.1| putative polyketide synthase [Mycobacterium tuberculosis 210] gi|326904561|gb|EGE51494.1| polyketide synthase pks1 [Mycobacterium tuberculosis W-148] Length=2107 Score = 3153 bits (8175), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1616/1616 (100%), Positives = 1616/1616 (100%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 492 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 551 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 552 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 611 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 612 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 671 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 672 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 731 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 732 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 791 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 792 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 851 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 852 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 911 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 912 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 971 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 972 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 1031 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 1032 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 1091 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 1092 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 1151 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 1152 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 1211 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 1212 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 1271 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 1272 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 1331 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 1332 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 1391 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 1392 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 1451 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 1452 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1511 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1512 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1571 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1572 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1631 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1632 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1691 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1692 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1751 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1752 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1811 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1812 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1871 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1872 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1931 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1932 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1991 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1992 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 2051 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 2052 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 2107 >gi|340627935|ref|YP_004746387.1| putative polyketide synthase PKS1 [Mycobacterium canettii CIPT 140010059] gi|340006125|emb|CCC45297.1| putative polyketide synthase PKS1 [Mycobacterium canettii CIPT 140010059] Length=1616 Score = 3152 bits (8173), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1612/1616 (99%), Positives = 1614/1616 (99%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 +ISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 1 MISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAP EAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 361 SLAPGEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFAS GADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 661 LPFCWRGVSLHAGGAGRVRARFASVGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDT+ELHRLPVTTWDVRCAPAA Sbjct 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTQELHRLPVTTWDVRCAPAA 1200 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA Sbjct 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 >gi|31794123|ref|NP_856616.1| polyketide synthase PKS1 [Mycobacterium bovis AF2122/97] gi|121638828|ref|YP_979052.1| putative polyketide synthase pks1 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224991320|ref|YP_002646009.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|81421699|sp|Q7TXK8.1|MSL7_MYCBO RecName: Full=Phenolphthiocerol synthesis polyketide synthase type I Pks15/1; AltName: Full=Beta-ketoacyl-acyl-carrier-protein synthase I gi|31619718|emb|CAD96658.1| PROBABLE POLYKETIDE SYNTHASE PKS1 [Mycobacterium bovis AF2122/97] gi|121494476|emb|CAL72957.1| Probable polyketide synthase pks1 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224774435|dbj|BAH27241.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341602867|emb|CCC65545.1| probable polyketide synthase pks1 [Mycobacterium bovis BCG str. Moreau RDJ] Length=2112 Score = 3151 bits (8170), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1614/1616 (99%), Positives = 1614/1616 (99%), Gaps = 0/1616 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL Sbjct 497 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 556 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD Sbjct 557 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 616 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA Sbjct 617 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 676 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES Sbjct 677 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 736 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG Sbjct 737 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 796 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ Sbjct 797 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 856 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR Sbjct 857 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 916 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN Sbjct 917 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 976 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV Sbjct 977 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 1036 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP Sbjct 1037 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 1096 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR Sbjct 1097 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 1156 Query 661 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 720 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA Sbjct 1157 LPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRA 1216 Query 721 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 780 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA Sbjct 1217 AVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESA 1276 Query 781 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 840 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM Sbjct 1277 GGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGM 1336 Query 841 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 900 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES Sbjct 1337 ARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAES 1396 Query 901 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 960 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL Sbjct 1397 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPL 1456 Query 961 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1020 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV Sbjct 1457 GAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVV 1516 Query 1021 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1080 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG Sbjct 1517 FLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMG 1576 Query 1081 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1140 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI Sbjct 1577 FDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDI 1636 Query 1141 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1200 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA Sbjct 1637 RDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAA 1696 Query 1201 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1260 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS Sbjct 1697 FRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLAS 1756 Query 1261 RRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1320 RRGDRAEGAAELAADLTEAGAK QVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL Sbjct 1757 RRGDRAEGAAELAADLTEAGAKGQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVL 1816 Query 1321 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAA 1380 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMF LCSSIAATVGSPGQGNYSAA Sbjct 1817 DDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFVLCSSIAATVGSPGQGNYSAA 1876 Query 1381 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1440 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL Sbjct 1877 NAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVEL 1936 Query 1441 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1500 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL Sbjct 1937 FDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSAL 1996 Query 1501 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 1560 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK Sbjct 1997 AQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLK 2056 Query 1561 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 2057 TATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 2112 >gi|289755061|ref|ZP_06514439.1| polyketide synthase pks1 [Mycobacterium tuberculosis EAS054] gi|289695648|gb|EFD63077.1| polyketide synthase pks1 [Mycobacterium tuberculosis EAS054] Length=1482 Score = 2893 bits (7500), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1479/1480 (99%), Positives = 1480/1480 (100%), Gaps = 0/1480 (0%) Query 137 DLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLV 196 DLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLV Sbjct 3 DLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLV 62 Query 197 VARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADR 256 VARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADR Sbjct 63 VARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADR 122 Query 257 FAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGS 316 FAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGS Sbjct 123 FAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGS 182 Query 317 AQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKD 376 AQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKD Sbjct 183 AQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKD 242 Query 377 RPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAA 436 RPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAA Sbjct 243 RPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAA 302 Query 437 GLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIR 496 GLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIR Sbjct 303 GLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIR 362 Query 497 AGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNA 556 AGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNA Sbjct 363 AGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNA 422 Query 557 EGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELF 616 EGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELF Sbjct 423 EGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELF 482 Query 617 AEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAG 676 AEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAG Sbjct 483 AEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAG 542 Query 677 RVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEV 736 RVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEV Sbjct 543 RVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEV 602 Query 737 VWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATH 796 VWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATH Sbjct 603 VWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATH 662 Query 797 TALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLID 856 TALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLID Sbjct 663 TALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLID 722 Query 857 TDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLV 916 TDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLV Sbjct 723 TDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLV 782 Query 917 IQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVT 976 I+PCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVT Sbjct 783 IRPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVT 842 Query 977 DLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKA 1036 DLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKA Sbjct 843 DLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKA 902 Query 1037 GESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEE 1096 GESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEE Sbjct 903 GESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEE 962 Query 1097 KFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYR 1156 KFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYR Sbjct 963 KFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYR 1022 Query 1157 AFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLT 1216 AFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLT Sbjct 1023 AFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLT 1082 Query 1217 MPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADL 1276 MPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADL Sbjct 1083 MPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADL 1142 Query 1277 TEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTV 1336 TEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTV Sbjct 1143 TEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTV 1202 Query 1337 LRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGL 1396 LRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGL Sbjct 1203 LRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGL 1262 Query 1397 AGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATL 1456 AGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATL Sbjct 1263 AGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATL 1322 Query 1457 LDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELL 1516 LDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELL Sbjct 1323 LDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELL 1382 Query 1517 VGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHP 1576 VGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHP Sbjct 1383 VGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHP 1442 Query 1577 TPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 TPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA Sbjct 1443 TPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1482 >gi|15826966|ref|NP_301229.1| polyketide synthase [Mycobacterium leprae TN] gi|221229444|ref|YP_002502860.1| putative polyketide synthase [Mycobacterium leprae Br4923] gi|13092513|emb|CAC29643.1| putative polyketide synthase [Mycobacterium leprae] gi|219932551|emb|CAR70228.1| putative polyketide synthase [Mycobacterium leprae Br4923] Length=2103 Score = 2576 bits (6676), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1338/1620 (83%), Positives = 1441/1620 (89%), Gaps = 7/1620 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+S RS AL AQA RL +VQA+P +DP+DVGC+LA+RSVFEHRAVVVG SREQLIAGL Sbjct 487 VVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALAARSVFEHRAVVVGESREQLIAGL 546 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 AGLA GE GAGVA+GQ +GKTVVVFPGQGAQRIGMGREL +LPVFA+ FDAV ELD Sbjct 547 AGLAVGESGAGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVFAEEFDAVTGELD 606 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RH+RLPLRDV+WGADA LLDSTEFAQPALFAVEVA FAVL+ WG+ PDFVMGHS+GELAA Sbjct 607 RHMRLPLRDVVWGADAGLLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAA 666 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 A+ AGVL ADAAMLVVARGRLMQ++PAGG M AVAASEDEV LLGEGVGIAAINAPES Sbjct 667 AYVAGVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEGVGIAAINAPES 726 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISG QAA +AIAD+FAAQGRRVHQLAVSHAFHSPLMEPMLEEF RVAA+V+ R+PQ+G Sbjct 727 VVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKPQIG 786 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 LVSNVTGELAGPDFGS QYW +HV R VRF DSARHLQTLGATHFIE+GP SGL G+IEQ Sbjct 787 LVSNVTGELAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFIESGPSSGLMGAIEQ 846 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SLAPAEA+VVSM+GKDRPELAS LGAAGQ+F TG+PV+W AVFAGS RRV LPTYAFQR Sbjct 847 SLAPAEAVVVSMMGKDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQR 906 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFWETPG DG A +GLGLG+TEHALLGAVVERPDS VVLTGRLSLA+QPWLADHV+ Sbjct 907 RRFWETPGTDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIG 966 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVELVIRAGDEVGCA +EELVLAAPLV+HPG GVQVQVVV AADES RAV Sbjct 967 GVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAV 1026 Query 541 SVYSRGDQSQG-WLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 SVYSRGDQS G WLLNAEG+L V AAE +DLS+WPPEGAESVDISD Y QLAERGYAYG Sbjct 1027 SVYSRGDQSHGGWLLNAEGLLEVDAAEATVDLSLWPPEGAESVDISDAYPQLAERGYAYG 1086 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAFQGLVAIWRRGSELFAEVVAP GV VD MGMHPA+LDAVLHALGLA+E TQA+TE Sbjct 1087 PAFQGLVAIWRRGSELFAEVVAP--TGVVVDGMGMHPALLDAVLHALGLAIENTQATTEM 1144 Query 660 RLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLR 719 RLPFCWRGVSLHAGGAGRVRARF SAGADAI+VD+ D+ GLPVLTVRSLVTR +TAEQLR Sbjct 1145 RLPFCWRGVSLHAGGAGRVRARFTSAGADAIAVDIADSAGLPVLTVRSLVTRAMTAEQLR 1204 Query 720 AAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWEL-- 777 AVTAAGGA +QGP+++VWSPI + S G +G P+ VSWAD+CAG D VVVWE Sbjct 1205 TAVTAAGGALEQGPMDLVWSPIPLSSDG-HGGGLPSVVSWADYCAGRGNDTGVVVWEFGS 1263 Query 778 ESAGGQAS-SVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAA 836 SAG QA V +VY+ATH AL+VLQ W G DRA TLVVLT G VGL GE ISDLAAAA Sbjct 1264 ASAGAQAPVDSVAAVYSATHAALQVLQFWFGQDRAGTLVVLTRGAVGLVGEGISDLAAAA 1323 Query 837 VWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALP 896 VWGM RSAQ+E+ G+IVLIDTD+AVD +VLA +GE QLLVR TVHA RLSPAP LLALP Sbjct 1324 VWGMVRSAQSEHSGKIVLIDTDSAVDVAVLADLGESQLLVRCNTVHAARLSPAPQLLALP 1383 Query 897 AAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQ 956 ES WRLAA GGGTLEDLVIQPCPEVQAPLQAG +RVAVAAVGVNFRDVVAALGMYPGQ Sbjct 1384 VGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMYPGQ 1443 Query 957 APPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAA 1016 APPLGAEGAGVV+E GPEVT +AVGDAVMGFLGGAGPLAVV QQL+T++PQGWS A+AAA Sbjct 1444 APPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLGGAGPLAVVHQQLITQMPQGWSLAEAAA 1503 Query 1017 VPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTL 1076 VPVVFLTA +GLADLA I+AGESVLIHAGTGGVGMAAVQ AR WGVE+FVTASRGKWDTL Sbjct 1504 VPVVFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTL 1563 Query 1077 RAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMG 1136 R MGFDDDHIGDSRT EFEEKFLAVT+GRGVDVVLDSLAG+FVDASLRLLVRGGRFLEMG Sbjct 1564 RDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFLEMG 1623 Query 1137 KTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRC 1196 KTDIRDAQEIAANYPGVQYRAFDLSEAGP RMQEML EVRELFDT+ LHRLPVT+WDVRC Sbjct 1624 KTDIRDAQEIAANYPGVQYRAFDLSEAGPVRMQEMLCEVRELFDTQVLHRLPVTSWDVRC 1683 Query 1197 APAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHL 1256 APAAFRFMSQARHIGKVVLTMPSALAD LA+GTV+ITGA+GA+GGVLARH+V AYGVRHL Sbjct 1684 APAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGAIGGVLARHMVSAYGVRHL 1743 Query 1257 VLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHA 1316 VLASRRGDRAEGA ELAA+L AGAK+QVVACDVAD AV GLFAQLSRE+PPVRGVIHA Sbjct 1744 VLASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHA 1803 Query 1317 AGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGN 1376 AGVLDD ITSLTPDR+DTVLRAKVDAAWNLH+AT DLDL MF LCSSIAATVGSPGQGN Sbjct 1804 AGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGN 1863 Query 1377 YSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAE 1436 YSAANAFLDGLAA+RQAAGLAG SLAWGLWEQPGGM AHLSSRDLAR+SRSGLAPM+PA+ Sbjct 1864 YSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPAQ 1923 Query 1437 AVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSS 1496 A+ELFDAAL IDHP V LLDRAALDA+AQAGALP LFS L RR RRRQI+D GDAT S Sbjct 1924 ALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQS 1983 Query 1497 KSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELR 1556 K AL QRL GLAA+ QLELLVG+VCLQAAAVLGRPS ED+DP+T+F DLGFDSLTAVELR Sbjct 1984 KLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELR 2043 Query 1557 NRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA 1616 NRLK+ATGLTLPPTVIFDHPTPTAVAEYVAQQM SRP ESGD TSQ VEP EVSVHA Sbjct 2044 NRLKSATGLTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA 2103 >gi|240171787|ref|ZP_04750446.1| putative polyketide synthase [Mycobacterium kansasii ATCC 12478] Length=2118 Score = 2450 bits (6350), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1335/1641 (82%), Positives = 1429/1641 (88%), Gaps = 36/1641 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SARSAEALTAQA RL AHVQA+PGL+P+DVGC+LA RSVFEHRAVVVGA RE LI GL Sbjct 489 VVSARSAEALTAQASRLAAHVQADPGLEPLDVGCTLAGRSVFEHRAVVVGADREALITGL 548 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 +A G+PGAGVAVGQ G VGKTVVVFPGQG+QR+GMGRELY LPVFA+AFD VADELD Sbjct 549 TSVADGDPGAGVAVGQAGPVGKTVVVFPGQGSQRLGMGRELYDRLPVFAEAFDEVADELD 608 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 +HLRLPLR+V+WG DA LLD+TEFAQPALFAVEVA FAVLR WGV PDFVMGHSVGEL+A Sbjct 609 QHLRLPLREVVWGGDAALLDTTEFAQPALFAVEVALFAVLRHWGVQPDFVMGHSVGELSA 668 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASE----DEVEPLLGEGVGIAAIN 236 A+ AGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASE DEV PLLGEGVGIAAIN Sbjct 669 AYVAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEKEVADEVMPLLGEGVGIAAIN 728 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 AP SV ISGA+AA +AIADRFA QGRRVH+LAVSHAFHSPLMEPML+EFAR+ AR++ R Sbjct 729 APASVTISGAEAAVSAIADRFAEQGRRVHRLAVSHAFHSPLMEPMLDEFARIVARLEPRT 788 Query 297 PQLGLVSNVTGELAGP--DFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGL 354 PQ+GLVSNVTGELA DFGSA YWVDHVRRPVRFADSARH+Q LGATHFIE GPGSGL Sbjct 789 PQIGLVSNVTGELASATGDFGSAPYWVDHVRRPVRFADSARHVQQLGATHFIEVGPGSGL 848 Query 355 TGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLP 414 T SIEQSLAPAEA VVSMLGKDRPELA+ALGAAGQ+FTTGVPV W AVFAGSGGRRV LP Sbjct 849 TSSIEQSLAPAEAFVVSMLGKDRPELAAALGAAGQLFTTGVPVDWPAVFAGSGGRRVDLP 908 Query 415 TYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWL 474 TYAFQRRRFWETPG DGPADA GLGLG TEHALLGAVVERPDSD VVLTGRLSLADQPWL Sbjct 909 TYAFQRRRFWETPGGDGPADAVGLGLGPTEHALLGAVVERPDSDGVVLTGRLSLADQPWL 968 Query 475 ADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADE 534 ADHVV GVVLFPGAGFVELVIRAGDEVGCA+I+EL+LAAPLVMHPG GV+VQVVVGAAD+ Sbjct 969 ADHVVGGVVLFPGAGFVELVIRAGDEVGCAVIDELILAAPLVMHPGAGVKVQVVVGAADD 1028 Query 535 SGHRAVSVYSRGDQSQG-WLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAE 593 +G RAVSVYSRGD G WLL+A G LG + A+ DLSVWPPEGAE VDISDGY +LA Sbjct 1029 AGTRAVSVYSRGDHCDGEWLLHAMGTLGESPAQASADLSVWPPEGAEIVDISDGYERLAA 1088 Query 594 RGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKT 653 RGYAYG AFQGLVA+WRR SELFAEVVAP + GVAV+ MGMHPAVLDAVLHALGLA+E Sbjct 1089 RGYAYGKAFQGLVAVWRRESELFAEVVAPAQHGVAVEGMGMHPAVLDAVLHALGLAIE-- 1146 Query 654 QASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPI 713 +TET LPFCWRGVSLHAGGAGRVRAR ASAGADAISV++ DA GLPVLTV +LVTR Sbjct 1147 --TTETMLPFCWRGVSLHAGGAGRVRARLASAGADAISVEIADAEGLPVLTVGALVTRAT 1204 Query 714 TAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPA---PVSWADFCAGSDGD- 769 TAEQLRAAV AAG DQGPLEVVWSPI + S PA +SW D+CA G Sbjct 1205 TAEQLRAAVNAAGRGPDQGPLEVVWSPIPLNHNSIEDSDEPAVLSALSWEDYCAADAGTP 1264 Query 770 ------------ASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVL 817 A+VVVWE S G A VGS YAATH L+VLQSWLG DRA TLVVL Sbjct 1265 AGANGNGAGAGDAAVVVWECGSVGADA---VGSTYAATHAGLQVLQSWLGTDRAGTLVVL 1321 Query 818 THGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVR 877 T G VGL GED+SDLAAAAVWG+ RSAQAE PGRIVL+D DA VDA LA VGEPQL+VR Sbjct 1322 TRGAVGLPGEDVSDLAAAAVWGLVRSAQAEQPGRIVLVDADAPVDAVALAAVGEPQLVVR 1381 Query 878 GGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVA 937 GG VH RL+PAP LLAL AE AWRLAAGGGGTLEDLVI+PCPE APLQAGQVRVAVA Sbjct 1382 GGVVHNARLAPAPPLLAL-PAEEAWRLAAGGGGTLEDLVIEPCPEALAPLQAGQVRVAVA 1440 Query 938 AVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVV 997 AVGVNFRDVVAALGMYPGQAPPLGAEGAGVV+ETGPEVT +AVGDAVMGFLGGAGPLAVV Sbjct 1441 AVGVNFRDVVAALGMYPGQAPPLGAEGAGVVIETGPEVTGVAVGDAVMGFLGGAGPLAVV 1500 Query 998 DQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLA 1057 DQQLV R P GWSFA+AAAVPVVFLTA +GL+DLAEIK GESVLIHAGTGGVGMAAVQLA Sbjct 1501 DQQLVVRAPHGWSFAEAAAVPVVFLTALFGLSDLAEIKGGESVLIHAGTGGVGMAAVQLA 1560 Query 1058 RQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGE 1117 R WGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGE Sbjct 1561 RHWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGE 1620 Query 1118 FVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRE 1177 FVDASLRLLVRGGRFLEMGKTDIRD Q+IAANYPGV+YRAFDLSEAGP RMQ ML EV+E Sbjct 1621 FVDASLRLLVRGGRFLEMGKTDIRDPQKIAANYPGVRYRAFDLSEAGPVRMQAMLREVKE 1680 Query 1178 LFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATG 1237 LFDT+ LHRLPV+TWDVRCAPAAFRFMSQARHIGKVVLTMPSALAD LADGTV+ITGATG Sbjct 1681 LFDTQVLHRLPVSTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADGTVLITGATG 1740 Query 1238 AVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVA 1297 VG VLARHLV AY VRH+VLASRRGDRA GAAELAA+L +AGA+VQVVACDVADR AVA Sbjct 1741 MVGAVLARHLVSAYRVRHVVLASRRGDRAAGAAELAAELADAGARVQVVACDVADRDAVA 1800 Query 1298 GLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLS 1357 GLF QL+ E+PPVRGVIHAAGV+DDAVI+SLTPDRIDTVLRAKVDAAWNLH+AT LDLS Sbjct 1801 GLFTQLAAEWPPVRGVIHAAGVVDDAVISSLTPDRIDTVLRAKVDAAWNLHEATRGLDLS 1860 Query 1358 MFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLS 1417 MF LCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAG SLAWGLWEQ +TAHLS Sbjct 1861 MFVLCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGTSLAWGLWEQTSAITAHLS 1920 Query 1418 SRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSG 1477 RDLARMSRSGL MSP +A+ELFDAAL IDHP+ VAT LDRAAL+ARAQAG LPALFSG Sbjct 1921 ERDLARMSRSGLVAMSPEQALELFDAALTIDHPVMVATRLDRAALNARAQAGGLPALFSG 1980 Query 1478 LARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVD 1537 LARRPRRRQIDDT DAT SKSALAQRLHGLA +EQ LLVG+V QAAAVLGRP+ ED+D Sbjct 1981 LARRPRRRQIDDTADATQSKSALAQRLHGLAPEEQHGLLVGIVRAQAAAVLGRPAPEDID 2040 Query 1538 PDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 PD+ F DLGFDSLTAVELRNRLK ATGLTLPPTVI DHPTPTAVA+Y+A+Q+ RP + Sbjct 2041 PDSGFQDLGFDSLTAVELRNRLKNATGLTLPPTVILDHPTPTAVADYIARQI---RPESN 2097 Query 1598 GD--PTSQVVEPAAAEVSVHA 1616 GD P ++ E +VSVHA Sbjct 2098 GDQSPHAERDEEDEEKVSVHA 2118 >gi|183981775|ref|YP_001850066.1| polyketide synthase Pks15/1 [Mycobacterium marinum M] gi|327488289|sp|B2HIL7.1|MSL7_MYCMM RecName: Full=Phenolphthiocerol synthesis polyketide synthase type I Pks15/1; AltName: Full=Beta-ketoacyl-acyl-carrier-protein synthase I gi|183175101|gb|ACC40211.1| polyketide synthase Pks15/1 [Mycobacterium marinum M] Length=2104 Score = 2405 bits (6233), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1298/1604 (81%), Positives = 1425/1604 (89%), Gaps = 12/1604 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRL+AHVQA+P +P+D+G SLA RS FEHRAVVVGA R+QL+ GL Sbjct 489 VISARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAGRSAFEHRAVVVGADRQQLLTGL 548 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 A LA G PGAGV GQ GSVGKT VVFPGQG+QRIGM REL+ +LPVFA+AFDAVADELD Sbjct 549 ATLADGAPGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARELHDQLPVFAEAFDAVADELD 608 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLR+PLR+V+WG+DA LLDSTEFAQPALFAVEVA FA L+ WG+ PDFVMGHSVGEL+A Sbjct 609 RHLRIPLREVMWGSDAALLDSTEFAQPALFAVEVALFAALQRWGLQPDFVMGHSVGELSA 668 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 A+ AGVLTLADAAMLVVARGRLMQALPAGGAMVAVAA+EDEV P L +GVGIAAINAP+S Sbjct 669 AYVAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAAINAPKS 728 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGA+AA AI+D+FA QGRRVH+LAVSHAFHSPLMEPMLEEFAR+AA+V+AREPQ+ Sbjct 729 VVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIAAQVEAREPQIA 788 Query 301 LVSNVTGELAGPD--FGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSI 358 LVSNVTGELA D FGSAQYWV+HVRR VRFADSAR L TLG THF+E GPGSGLTGSI Sbjct 789 LVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQLHTLGVTHFVEVGPGSGLTGSI 848 Query 359 EQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAF 418 EQSLAPAEA+VVSMLGKDRPE+AS L A GQ+F+TG+ V W AVFAGSG RV LPTYAF Sbjct 849 EQSLAPAEAVVVSMLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAF 908 Query 419 QRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHV 478 QRRRFWE PGADGPADA GLGLG EHALLGAVVERPDS VVLTGRL+LADQPWLADHV Sbjct 909 QRRRFWEVPGADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHV 968 Query 479 VNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHR 538 + GVVLFPGAGFVEL IRAGDEVGCA++EELVLAAPLV+HPG+GVQVQV+VGAAD+SG+R Sbjct 969 IGGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGAADDSGNR 1028 Query 539 AVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAY 598 A+SVYSRGDQS+ WLLNAEGMLGV AA + DLSVWPPEGAESVDISDGYAQLA+RGYAY Sbjct 1029 ALSVYSRGDQSEDWLLNAEGMLGVEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAY 1088 Query 599 GPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTE 658 GP FQGLV +WRR SELFAEVVAP +GVAVD+MGMHP VLDAVLHALGL E+ S E Sbjct 1089 GPGFQGLVGVWRRDSELFAEVVAP--SGVAVDKMGMHPVVLDAVLHALGLTAEQNPDSDE 1146 Query 659 TRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 T+LPFCWRGVSLHAGGAGRVRAR +G D+ISV++ DA GLPVLTV +LVTR ++A QL Sbjct 1147 TKLPFCWRGVSLHAGGAGRVRARLTMSGPDSISVEIADAAGLPVLTVGALVTRAMSAAQL 1206 Query 719 RAAVTAAGGAS-DQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVV--- 774 RAAV AAGG + DQGPL+V+WSPI + G NGSA PA VSWADFCAG DG A+ Sbjct 1207 RAAVAAAGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAAGDAGVV 1266 Query 775 -WELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLA 833 WE AG VVGSVYAATH ALEVLQSW DRA TLVVLTHG V + GE++SDLA Sbjct 1267 VWEPNPAG---EDVVGSVYAATHAALEVLQSWFDGDRAGTLVVLTHGAVAMPGENVSDLA 1323 Query 834 AAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALL 893 AAVWG+ RSAQAENPGRIVL+D DAAV+A+ L VGEPQL+VR G HA RL+PA LL Sbjct 1324 GAAVWGIVRSAQAENPGRIVLVDADAAVEAAELVAVGEPQLVVRSGAAHAARLAPAAPLL 1383 Query 894 ALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMY 953 A+PA ESAWRLAAGGGGTLEDLVI+PCPEVQAPL AGQVRVAV AVGVNFRDVVAALGMY Sbjct 1384 AVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMY 1443 Query 954 PGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQ 1013 PG+APPLGAEGAGVVLE GP+V+ +AVGD+VMGFLGGAGPL+VVDQQL+TR+PQGWSFAQ Sbjct 1444 PGEAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFLGGAGPLSVVDQQLITRMPQGWSFAQ 1503 Query 1014 AAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKW 1073 AAAVPVVFLTA +GL DLA+I+ GESVLIHAGTGGVGMAAVQLAR WGVE+FVTASRGKW Sbjct 1504 AAAVPVVFLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKW 1563 Query 1074 DTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFL 1133 DTLRAMGFDDDHIGDSRT +FEEKFLAVT+GRGVDVVLDSLAG+FVDASLRLLVRGGRFL Sbjct 1564 DTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFL 1623 Query 1134 EMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWD 1193 EMGKTDIRDA +IAANYPGV YRAFDLSEAGP RMQEMLAEVRELFDT LHRLPVTTWD Sbjct 1624 EMGKTDIRDADKIAANYPGVWYRAFDLSEAGPVRMQEMLAEVRELFDTAVLHRLPVTTWD 1683 Query 1194 VRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGV 1253 VRCAPAAFRFMSQARHIGKVVLTMPSALAD LAD TV+ITGATGAVG VLARH++ AYGV Sbjct 1684 VRCAPAAFRFMSQARHIGKVVLTMPSALADGLADATVLITGATGAVGAVLARHMLDAYGV 1743 Query 1254 RHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGV 1313 RHLVLASRRGDRAEGAAELAA+L+EAGA VQVVACDVADR AV + A+LS EYPPVRGV Sbjct 1744 RHLVLASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGV 1803 Query 1314 IHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPG 1373 IHAAGVLDDAVI+SLTP+RIDTVLRAKVDAAWNLH+AT DLDLSMF LCSSIAATVGSPG Sbjct 1804 IHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGSPG 1863 Query 1374 QGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMS 1433 QGNYSAAN+FLDGLAAHRQAAGLAGIS+AWGLWEQ GGM AHLSSRDLARMSRSGLAPM+ Sbjct 1864 QGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDLARMSRSGLAPMN 1923 Query 1434 PAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDA 1493 P +AV L DA LAI+HPL VATLLDR AL+ARAQAG LP LF+G+ RRPRRRQI+DTGDA Sbjct 1924 PEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDA 1983 Query 1494 TSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAV 1553 SKSALA+RL+GL+A E+ + LVGLVCLQAAAVLGRPS ED+DP+ F DLGFDSLTAV Sbjct 1984 AQSKSALAERLNGLSAGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAV 2043 Query 1554 ELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 ELRNRLK+ATGLTLPPTVIFDHPTPTA+AEYV +Q+ S+ T++ Sbjct 2044 ELRNRLKSATGLTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQA 2087 >gi|118617583|ref|YP_905915.1| polyketide synthase Pks15/1 [Mycobacterium ulcerans Agy99] gi|118569693|gb|ABL04444.1| polyketide synthase Pks15/1 [Mycobacterium ulcerans Agy99] Length=2104 Score = 2396 bits (6209), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1288/1604 (81%), Positives = 1415/1604 (89%), Gaps = 12/1604 (0%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 VISARSAEALTAQAGRL+AHVQA+P +P+D+G SLA RS FEHRAVVVGA R+QL+ GL Sbjct 489 VISARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAGRSAFEHRAVVVGADRQQLLTGL 548 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 A LA G PGAGV GQ GSVGKT VVFPGQG+QRIGM REL+ +LPVFA+AFDAVADELD Sbjct 549 ATLADGAPGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARELHDQLPVFAEAFDAVADELD 608 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHLR+PL +V+WG+D LLDSTEFAQ ALFAVEVA FA L+ WG+ PDFVMGHSVGEL+A Sbjct 609 RHLRIPLCEVMWGSDVALLDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSA 668 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 A+ AGVLTL DAAMLVVARGRLMQALPAGGAMVAVAA+EDEV P L +GVGIAAINAP+S Sbjct 669 AYVAGVLTLVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDGVGIAAINAPKS 728 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISGA+AA AI+D+FA QGRRVH+LAVSHAFHSPLMEPMLEEFAR+AA+V+AREPQ+ Sbjct 729 VVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIAAQVEAREPQIA 788 Query 301 LVSNVTGELAGPD--FGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSI 358 LVSNVTGELA D FGSAQYWV+HVRR VRFADSAR L TLG THF+E GPGSGLTGSI Sbjct 789 LVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQLHTLGVTHFVEVGPGSGLTGSI 848 Query 359 EQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAF 418 EQSLAPAEA+VVSMLGKDRPE+AS L A GQ+F+TG+ V W AVFAGSG RV LPTYAF Sbjct 849 EQSLAPAEAVVVSMLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAF 908 Query 419 QRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHV 478 QRRRFWE PGADGPADA GLGLG EHALLGAVVERPDS VVLTGRL+LADQPWLADHV Sbjct 909 QRRRFWEVPGADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHV 968 Query 479 VNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHR 538 + GVVLFPGAGFVEL IRAGDEVGCA++EELVLAAPLV+HPG+GVQVQV+VG AD+SG+R Sbjct 969 IGGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGTADDSGNR 1028 Query 539 AVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAY 598 A+SVYSRGD+S+ WLLNAEGMLGV AA + DLSVWPPEGAESVDISDGYAQLA+RGYAY Sbjct 1029 ALSVYSRGDKSEDWLLNAEGMLGVEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAY 1088 Query 599 GPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTE 658 GP FQGLV +WRR SELFAEVVAP +GVAVD+MGMHP VLDAVLHALGL E+ S E Sbjct 1089 GPGFQGLVGVWRRDSELFAEVVAP--SGVAVDKMGMHPVVLDAVLHALGLTAEQNPDSDE 1146 Query 659 TRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 T+LPFCWRGVSLHAGGAGRVRAR +G D+ISV++ DA GLPVLTV +LVTR ++A QL Sbjct 1147 TKLPFCWRGVSLHAGGAGRVRARLTMSGPDSISVEIADAAGLPVLTVGALVTRAMSAAQL 1206 Query 719 RAAVTAAGGAS-DQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVV--- 774 RAAV AGG + DQGPL+V+WSPI + G NGSA PA VSWADFCAG DG A+ Sbjct 1207 RAAVAEAGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAAGDAGVV 1266 Query 775 -WELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLA 833 WE AG VVG VYAATH ALEVLQSW DRA TLVVLTHG V + GE++SDLA Sbjct 1267 VWEPNPAG---EDVVGPVYAATHAALEVLQSWFDGDRAGTLVVLTHGAVAMPGENVSDLA 1323 Query 834 AAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALL 893 AAVWG+ RSAQAENPGRIVL+D DAAV+A+ L VGEPQL+VR G HA RL+PA LL Sbjct 1324 GAAVWGIVRSAQAENPGRIVLVDADAAVEAAELVAVGEPQLVVRSGAAHAARLAPAAPLL 1383 Query 894 ALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMY 953 A+PA ESAWRLAAGGGGTLEDLVI+PCPEVQAPL AGQVRVAV AVGVNFRDVVAALGMY Sbjct 1384 AVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMY 1443 Query 954 PGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQ 1013 PG APPLGAEGAGVVLE GP+V+ +AVGD+VMGFLGGAGPL+VVDQQL+TR+PQGWSFAQ Sbjct 1444 PGAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFLGGAGPLSVVDQQLITRMPQGWSFAQ 1503 Query 1014 AAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKW 1073 AAAVPVVFLTA +GL DLA+I+ GESVLIHAGTGGVGMAAVQLAR WGVE+FVTASRGKW Sbjct 1504 AAAVPVVFLTALFGLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASRGKW 1563 Query 1074 DTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFL 1133 DTLRAMGFDDDHIGDSRT +FEEKFLAVT+GRGVDVVLDSLAG+FVDASLRLLVRGGRFL Sbjct 1564 DTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGDFVDASLRLLVRGGRFL 1623 Query 1134 EMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWD 1193 EMGKTDIRDA +IAANYPGV YRAFDLSEAGP RMQEMLAEVRELFDT LHRLPVTTWD Sbjct 1624 EMGKTDIRDADKIAANYPGVWYRAFDLSEAGPVRMQEMLAEVRELFDTAVLHRLPVTTWD 1683 Query 1194 VRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGV 1253 VRCAPAAFRFMSQARHIGKVVLTMPSALAD LAD TV+ITGATGAVG VLARH++ YGV Sbjct 1684 VRCAPAAFRFMSQARHIGKVVLTMPSALADGLADATVLITGATGAVGAVLARHMLDGYGV 1743 Query 1254 RHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGV 1313 RHLVLASRRGDRAEGAAELAA+L+EAGA VQVVACDVADR AV + A+LS EYPPVRGV Sbjct 1744 RHLVLASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGV 1803 Query 1314 IHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPG 1373 IHAAGVLDDAVI+SLTP+RIDTVLRAKVDAAWNLH+AT DLDLSMF LCSSIAATVGSPG Sbjct 1804 IHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGSPG 1863 Query 1374 QGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMS 1433 QGNYSAAN+FLDGLAAHRQAAGLAGIS+AWGLWEQ GGM AHLSSRDLARMSRSGLAPM+ Sbjct 1864 QGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDLARMSRSGLAPMN 1923 Query 1434 PAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDA 1493 P +AV L DA LAI+HPL VATLLDR AL+ARAQAG LP LF+G+ RRPRRRQI+DTGDA Sbjct 1924 PEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDA 1983 Query 1494 TSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAV 1553 SKSALA+RL+GL+A E+ + LVGLVCLQAAAVLGRPS ED+DP+ F DLGFDSLTAV Sbjct 1984 AQSKSALAERLNGLSAGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAV 2043 Query 1554 ELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 ELRNR K+ATGLTLPPTVIFDHPTPTA+AEYV +Q+ S+ T++ Sbjct 2044 ELRNRFKSATGLTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQA 2087 >gi|289751620|ref|ZP_06510998.1| polyketide synthase pks1 [Mycobacterium tuberculosis T92] gi|289692207|gb|EFD59636.1| polyketide synthase pks1 [Mycobacterium tuberculosis T92] Length=1001 Score = 1959 bits (5074), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1000/1001 (99%), Positives = 1001/1001 (100%), Gaps = 0/1001 (0%) Query 281 MLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTL 340 MLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTL Sbjct 1 MLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTL 60 Query 341 GATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWS 400 GATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWS Sbjct 61 GATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWS 120 Query 401 AVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEV 460 AVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEV Sbjct 121 AVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEV 180 Query 461 VLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPG 520 VLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPG Sbjct 181 VLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPG 240 Query 521 VGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAE 580 VGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAE Sbjct 241 VGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAE 300 Query 581 SVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLD 640 SVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLD Sbjct 301 SVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLD 360 Query 641 AVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGL 700 AVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGL Sbjct 361 AVLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGL 420 Query 701 PVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWA 760 PVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWA Sbjct 421 PVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWA 480 Query 761 DFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHG 820 DFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHG Sbjct 481 DFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHG 540 Query 821 GVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGT 880 GVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGT Sbjct 541 GVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGT 600 Query 881 VHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVG 940 VHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVI+PCPEVQAPLQAGQVRVAVAAVG Sbjct 601 VHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIRPCPEVQAPLQAGQVRVAVAAVG 660 Query 941 VNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQ 1000 VNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQ Sbjct 661 VNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQ 720 Query 1001 LVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQW 1060 LVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQW Sbjct 721 LVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQW 780 Query 1061 GVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVD 1120 GVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVD Sbjct 781 GVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVD 840 Query 1121 ASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFD 1180 ASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFD Sbjct 841 ASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFD 900 Query 1181 TRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVG 1240 TRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVG Sbjct 901 TRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVG 960 Query 1241 GVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGA 1281 GVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGA Sbjct 961 GVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGA 1001 >gi|183983098|ref|YP_001851389.1| polyketide synthase and peptide synthetase [Mycobacterium marinum M] gi|183176424|gb|ACC41534.1| polyketide synthase and peptide synthetase [Mycobacterium marinum M] Length=2831 Score = 1828 bits (4734), Expect = 0.0, Method: Compositional matrix adjust. Identities = 1019/1600 (64%), Positives = 1196/1600 (75%), Gaps = 22/1600 (1%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S +AL AQA RL+ V + GLDP+DVG SLA R VFEHRAVVVG RE L+AGL Sbjct 1159 VLSAQSRQALVAQASRLLGRVGGDDGLDPVDVGLSLAQRCVFEHRAVVVGRDREALLAGL 1218 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 GLA G PGAGV VGQ +VGKTV+VFPGQGAQ GMGR L+G+ P FA+AFDA DELD Sbjct 1219 TGLARGGPGAGVVVGQAAAVGKTVLVFPGQGAQWTGMGRGLHGQFPAFARAFDAAVDELD 1278 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 +HL +PLR+V+WG D LLDSTEFAQPALFA+EV +A+L WG+ PDFV+GHSVGEL+A Sbjct 1279 QHLPMPLREVMWGTDKGLLDSTEFAQPALFALEVGLWALLEHWGIRPDFVLGHSVGELSA 1338 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEG---VGIAAINA 237 AH AGVL+LADAAMLV ARGRLMQ LPAGG MVA+ E EV+PLL E V IAAINA Sbjct 1339 AHVAGVLSLADAAMLVAARGRLMQGLPAGGVMVALGVGEQEVDPLLAESAHPVSIAAINA 1398 Query 238 PESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREP 297 PE VVISGAQAA IAD+ AA+G RV QLAVSHAFHSPLMEP++EEFA +A RV P Sbjct 1399 PEQVVISGAQAAVMTIADQLAARGHRVQQLAVSHAFHSPLMEPIVEEFAEIAGRVTVEAP 1458 Query 298 QLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGS 357 ++G++SN+TGELAGP +GS YW +H+RRPVRF+DS + GATHF+EAGPG+GLT + Sbjct 1459 RIGVISNLTGELAGPGYGSKAYWREHIRRPVRFSDSVACARAQGATHFVEAGPGAGLTAA 1518 Query 358 IEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYA 417 IEQSL A VV++LGK RPE S L AA Q+F +G + W AVF G GGRRV LPTYA Sbjct 1519 IEQSLGSVAATVVAVLGKQRPEPDSLLDAAAQLFASGARLDWPAVFLGWGGRRVSLPTYA 1578 Query 418 FQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADH 477 F R+RFW TP G AA LG G H LL AVVE PDS EV+L GRLS QPWLADH Sbjct 1579 FMRQRFWLTPHLAGSVGAAELGSGNPRHPLLDAVVEHPDSGEVILAGRLSRRAQPWLADH 1638 Query 478 VVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGH 537 V+ G+VL PG GFVELVIRAGD++GCA I+EL L PL++ G VQVQVVVGAA+ SG Sbjct 1639 VIGGLVLLPGTGFVELVIRAGDQLGCAAIDELTLTNPLIVPDGSEVQVQVVVGAAERSGR 1698 Query 538 RAVSVYSRGDQ-SQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGY 596 R VSVYSR D W+ +AEG LGV D SVWPP GAE+V +SD Y +LA+ GY Sbjct 1699 RTVSVYSRADHIGAAWVQHAEGALGVDPMPASGDFSVWPPSGAEAVRVSDAYERLAQLGY 1758 Query 597 AYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQAS 656 YGPAF+G+ AIWRRG+E++AEV P +A + ++ G+HP +LDAVL A +AV+ S Sbjct 1759 RYGPAFRGIEAIWRRGTEVYAEVAIPADAELGINGYGIHPVLLDAVLQAAAVAVD----S 1814 Query 657 TETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAE 716 +TRLP+ WRG+SLHA A R+RAR A G +V+ D GLPVLT+ SLVTRP++AE Sbjct 1815 GDTRLPYSWRGISLHAAAAKRIRARIAPVGEVGYAVECADVAGLPVLTMGSLVTRPVSAE 1874 Query 717 QLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDAS----- 771 QL A A G QG LE+ WSPIS G +G +SWADF AG+ A Sbjct 1875 QLHAGAATAIGRPAQGLLELAWSPISPAHGALDGGGHQTVLSWADFTAGAAAAADGVGGR 1934 Query 772 --VVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDI 829 VVWE +A + VVGSVYA H AL VLQ WL D+ A+LVV+THG VGL GE I Sbjct 1935 AVAVVWESRTA---ETDVVGSVYARIHAALSVLQHWLAQDQLASLVVVTHGAVGLPGEAI 1991 Query 830 SDLAAAAVWGMARSAQAENPGRIVLIDTDA--AVDASVLAGVGEPQLLVRGGTVHAPRLS 887 +DLA +AVWG+ARSAQAE+PGRIVL+D D D VL EPQL+VRG +V RL Sbjct 1992 TDLAGSAVWGLARSAQAESPGRIVLVDIDTPNTPDLGVLLAGREPQLVVRGDSVFCARLR 2051 Query 888 PAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVV 947 P A L +P +SAW+L+ GGGGTL D+V+QPCP QAPL+ GQVRVAVAA GVNFRDV+ Sbjct 2052 PVEAPLEVPVGQSAWQLSTGGGGTLADIVVQPCPPAQAPLEPGQVRVAVAAAGVNFRDVL 2111 Query 948 AALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQ 1007 ALGMYPG P LG EG+GVVLE GP+V+ + VGDAVMG + G GPLAVVD +L+ RVP Sbjct 2112 MALGMYPGAQPVLGGEGSGVVLEVGPQVSGVGVGDAVMGLIAGVGPLAVVDARLLVRVPS 2171 Query 1008 GWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVT 1067 GWS A+AA VPV FLTAWYGLADLA ++AGESVL+HAGTGGVGMAAVQLAR WG +VFVT Sbjct 2172 GWSLAEAAGVPVAFLTAWYGLADLAGVRAGESVLVHAGTGGVGMAAVQLARLWGAKVFVT 2231 Query 1068 ASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLV 1127 ASRGKWDTLR+MGFDD IGDSR+ EF EKF A T GRGVDVVL+SLAGEFVDASLRLL Sbjct 2232 ASRGKWDTLRSMGFDDSRIGDSRSLEFAEKFFAATRGRGVDVVLNSLAGEFVDASLRLLA 2291 Query 1128 RGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRL 1187 GGRF+EMGKTDIRD Q+IA YPGV Y AFDL EAGPAR+Q ML ++ LF+ L L Sbjct 2292 PGGRFIEMGKTDIRDPQQIAVEYPGVIYEAFDLIEAGPARIQPMLGQLHTLFEASALESL 2351 Query 1188 PVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHL 1247 P TWD RCAPAA+RF+SQAR IGKVVLTMP+ ++D +A GTV+ITG TG V VLARHL Sbjct 2352 PTRTWDARCAPAAYRFVSQARQIGKVVLTMPTQISDAVAAGTVLITGGTGMVASVLARHL 2411 Query 1248 VGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREY 1307 V +YGV+H+VLASRR D G AEL ADL AGA V VVACDVADRAAV L +S + Sbjct 2412 VSSYGVKHVVLASRRADATAGVAELVADLAAAGAAVAVVACDVADRAAVTRLLDHVSTCH 2471 Query 1308 PPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAA 1367 PP+ GVIHAAG LDDAVI SLTPDR+D VLRAKVD AWNLH+AT L LSMF LCSSIAA Sbjct 2472 PPLTGVIHAAGTLDDAVIASLTPDRVDAVLRAKVDGAWNLHEATRHLGLSMFVLCSSIAA 2531 Query 1368 TVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRS 1427 TVGS GQ NY+A NAFLDGLAA+R+A GL G+SL WGLWEQ MTAHLS RD+AR+ R Sbjct 2532 TVGSSGQANYAAGNAFLDGLAAYRRAGGLPGMSLGWGLWEQSSTMTAHLSDRDMARIRRI 2591 Query 1428 GLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQI 1487 GLA +SP +A++LFDAALA+ P +A LD A L + LP LFS L +RP RR + Sbjct 2592 GLAAISPEQAMQLFDAALAVGQPTVLAAHLDHAVLANHTLSSTLPPLFSTLIKRPLRRLV 2651 Query 1488 DDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGF 1547 D+ D SS + AQRL+GL ++Q +LLV LVC QAAAVLG PSA D++P + F ++GF Sbjct 2652 DN--DTPSSTAGFAQRLYGLKPEKQQDLLVDLVCTQAAAVLGHPSATDLNPASTFQNMGF 2709 Query 1548 DSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQ 1587 DSLTAVELRNRLKT TGL L PT++FDHPTPTA+A +A+ Sbjct 2710 DSLTAVELRNRLKTVTGLGLSPTLVFDHPTPTALAGLIAE 2749 Score = 50.4 bits (119), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/64 (46%), Positives = 36/64 (57%), Gaps = 1/64 (1%) Query 1514 ELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIF 1573 E L+ +VC QAA VLG A VD D GD G +S+ EL +RL G + P IF Sbjct 600 EQLLSVVCGQAAEVLGI-GAASVDIDRSLGDQGLNSIGVTELASRLTQVLGQDVQPVDIF 658 Query 1574 DHPT 1577 +HPT Sbjct 659 NHPT 662 >gi|254552020|ref|ZP_05142467.1| polyketide synthase pks1 [Mycobacterium tuberculosis '98-R604 INH-RIF-EM'] Length=909 Score = 1777 bits (4602), Expect = 0.0, Method: Compositional matrix adjust. Identities = 908/909 (99%), Positives = 909/909 (100%), Gaps = 0/909 (0%) Query 708 LVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSD 767 +VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSD Sbjct 1 MVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSD 60 Query 768 GDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGE 827 GDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGE Sbjct 61 GDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGE 120 Query 828 DISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLS 887 DISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLS Sbjct 121 DISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLS 180 Query 888 PAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVV 947 PAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVV Sbjct 181 PAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVV 240 Query 948 AALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQ 1007 AALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQ Sbjct 241 AALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQ 300 Query 1008 GWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVT 1067 GWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVT Sbjct 301 GWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVT 360 Query 1068 ASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLV 1127 ASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLV Sbjct 361 ASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLV 420 Query 1128 RGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRL 1187 RGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRL Sbjct 421 RGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRL 480 Query 1188 PVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHL 1247 PVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHL Sbjct 481 PVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHL 540 Query 1248 VGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREY 1307 VGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREY Sbjct 541 VGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREY 600 Query 1308 PPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAA 1367 PPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAA Sbjct 601 PPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAA 660 Query 1368 TVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRS 1427 TVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRS Sbjct 661 TVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRS 720 Query 1428 GLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQI 1487 GLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQI Sbjct 721 GLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQI 780 Query 1488 DDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGF 1547 DDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGF Sbjct 781 DDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGF 840 Query 1548 DSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEP 1607 DSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEP Sbjct 841 DSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEP 900 Query 1608 AAAEVSVHA 1616 AAAEVSVHA Sbjct 901 AAAEVSVHA 909 >gi|342860754|ref|ZP_08717404.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342131778|gb|EGT85035.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=2121 Score = 1699 bits (4400), Expect = 0.0, Method: Compositional matrix adjust. Identities = 962/1596 (61%), Positives = 1149/1596 (72%), Gaps = 49/1596 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLAS-RSVFEHRAVVVGASREQLIAG 59 VISARS EAL QA RL+ + A+ +DVG SLA+ R+ FEHRAV++G RE L G Sbjct 479 VISARSPEALAGQAQRLLDRLSADADARAVDVGWSLATNRAAFEHRAVLIGRDREALTTG 538 Query 60 LAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LAGLA+G P G VG+ GK V VFPGQG+Q +GMG ELY P FAQAFD + Sbjct 539 LAGLASGRPDPGALVGRTRPAGKRVFVFPGQGSQSLGMGAELYDRFPAFAQAFDEAVAAV 598 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 D H RLPLR+V+WG D +LL STEFAQPALF VE+A A+ + +G+ PD V+GHSVGE+A Sbjct 599 DAHARLPLREVMWGTDPELLQSTEFAQPALFVVEIALAALWQSFGITPDVVIGHSVGEIA 658 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AA AG + L DAA LV ARGRLM LPAGG MVAV+A+E EV LL V IAA+N P Sbjct 659 AACVAGAMPLPDAARLVAARGRLMAGLPAGGVMVAVSATEAEVAGLLNGAVSIAAVNGPR 718 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 S+V+SG + A A+ADR AA G RVH+LAVSHAFHSPLMEPM+ EFA VAA V A +P++ Sbjct 719 SLVLSGERDAVGAVADRLAAGGARVHRLAVSHAFHSPLMEPMMGEFAAVAAGVSAGQPRI 778 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 LVSN+TG+LAGPD+G+A YWVDHVR+PVRF D + ++LGA F+E GPG+ LT ++E Sbjct 779 ALVSNLTGQLAGPDYGTAGYWVDHVRKPVRFVDGVQLAESLGAGVFLEVGPGAALTSAVE 838 Query 360 QSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQ 419 QSL A V + KDRPE+ S L AAGQ+FT G V+W+A FA RRV+LPTYAF Sbjct 839 QSLTTERATSVVSMAKDRPEVDSLLRAAGQLFTAGADVRWAAAFADGWARRVELPTYAFV 898 Query 420 RRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRRFW + + G A+ A LGL EHALLGAVV+RPDS VVLTGRLS+A QPWLADH V Sbjct 899 RRRFWLSSDSVGSANIASLGLAEAEHALLGAVVDRPDSGGVVLTGRLSIAAQPWLADHAV 958 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 G VLFPGAGFVEL +RAGDEVGC+++EEL LAAPLV+ V +QVVV A ++G R Sbjct 959 AGTVLFPGAGFVELALRAGDEVGCSVVEELTLAAPLVVPAAGVVHLQVVVAGAGDAGTRT 1018 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 V+VYSR QS W+L+AEG+L A DLSVWPP GA++VD++ Y LA RGY YG Sbjct 1019 VTVYSRAAQSD-WVLHAEGVLSGGAPAPDTDLSVWPPPGADAVDVTGAYDGLAGRGYGYG 1077 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL +WRRG+E FAEV P +AGVA G+HP +LDA LHALG+A E+ ET Sbjct 1078 PAFRGLRTVWRRGTETFAEVELPEQAGVATGGFGIHPVLLDAALHALGVADER----IET 1133 Query 660 RLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLR 719 LPF W+GV L+A GA RVR R A GA A+SV++ D++GLPVL+VR LVTR ++A+QL Sbjct 1134 VLPFSWQGVCLNAAGASRVRVRLAPVGAGAVSVELADSSGLPVLSVRELVTRAVSADQLA 1193 Query 720 AAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELES 779 AAV A G+ + L+VVWSP+S PP G+D + + VWE Sbjct 1194 AAVAARSGSGEL--LDVVWSPVS----------PP----------GNDVGSDITVWESPP 1231 Query 780 AGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWG 839 AG A VGSVY ATH AL VLQSWL A++A LVVLT G VGLAGED++DLA AAVWG Sbjct 1232 AGPGA---VGSVYRATHEALGVLQSWLTAEQAGVLVVLTRGAVGLAGEDVADLAGAAVWG 1288 Query 840 MARSAQAENPGRIVLIDTDAAVD-ASVLAGVGEPQLLVRGGTVHAPRLSPAPA--LLALP 896 + RSAQAE+PGR+VL+DTD +D A+V+ G GEPQL+VR G ++ RL PA LL LP Sbjct 1289 LTRSAQAEHPGRVVLVDTDGTLDVAAVIGGCGEPQLVVRDGVAYSARLKPADQRPLLRLP 1348 Query 897 AAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQ 956 SAWRLAAG GTLEDL +Q P A L++GQVRV VAA GVNFRDV+ ALGMYPG Sbjct 1349 DPPSAWRLAAGDAGTLEDLAVQEYPP--AALESGQVRVTVAAAGVNFRDVLVALGMYPGA 1406 Query 957 APPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAA 1016 A LGAEGAG+V E G V DLAVGDAVMG G AG A VD++LVTRVP+GWS AQAAA Sbjct 1407 A-QLGAEGAGIVTELGAGVADLAVGDAVMGIFGLAGSEAAVDRRLVTRVPRGWSMAQAAA 1465 Query 1017 VPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTL 1076 VPVVFLTA+YGL+ LA ++AG+ VL+HA TGGVGMAAVQLAR WG EVF TASRGKWDTL Sbjct 1466 VPVVFLTAYYGLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTL 1525 Query 1077 RAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMG 1136 R MGFDD HI DSRT +FE+KF G+DVVL+SLAGEF DASLRLL GGRF+EMG Sbjct 1526 RVMGFDDAHIADSRTLDFEQKFAG-----GMDVVLNSLAGEFNDASLRLLGPGGRFIEMG 1580 Query 1137 KTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRC 1196 KTD+RD +AA++PGV YRAFDL EAGP R+ EMLAE+ +LF L LPV +D R Sbjct 1581 KTDLRDPDAVAADHPGVTYRAFDLMEAGPDRIAEMLAELMDLFARGVLMPLPVKEFDARS 1640 Query 1197 APAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHL 1256 A A+RF+SQARH+GKVVLTMP A LA GT +ITG TG G +ARHLV + V H+ Sbjct 1641 AADAYRFVSQARHVGKVVLTMPDGPAG-LAGGTALITGGTGMAGSAVARHLVERHRVPHV 1699 Query 1257 VLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHA 1316 +L SR G+RA G A+LAA+L E GA V V ACDV DR AVA L AQ+ Y P+R V HA Sbjct 1700 LLVSRSGERAGGMADLAAELRELGASVSVAACDVGDRDAVAELLAQVPARY-PLRSVFHA 1758 Query 1317 AGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGN 1376 AGVLDDAV+ SLTP RIDTVLRAKVD AWNLH+ T L+LS F SS+A VG+PGQGN Sbjct 1759 AGVLDDAVLASLTPARIDTVLRAKVDGAWNLHELTGGLNLSAFVAFSSMAGIVGAPGQGN 1818 Query 1377 YSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAE 1436 Y+AAN+FLD LAAHR+ GL G+S+AWG+WE+ MT HL RD ARMSR+GL+ +S + Sbjct 1819 YAAANSFLDALAAHRRTRGLPGLSVAWGMWEETSTMTQHLGERDKARMSRAGLSALSTRQ 1878 Query 1437 AVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSS 1496 A+EL DAAL + P+ VAT LDRAAL LP L S LA RP RR ++ T S Sbjct 1879 ALELLDAALLTEQPMVVATRLDRAALAHHGD--TLPPLLSQLATRPARRVLEHTD--MVS 1934 Query 1497 KSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELR 1556 + L RL G+ D++ LV LVC AA VLG S DV+ D FGDLGFDSLTAVELR Sbjct 1935 LTGLRARLEGMTPDQRHSELVELVCSNAATVLGH-SFADVNADDAFGDLGFDSLTAVELR 1993 Query 1557 NRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS 1592 NRLK ATGLTL PT+IFD PTP A+AE++ Q++GS Sbjct 1994 NRLKIATGLTLSPTLIFDQPTPGALAEHLGAQLAGS 2029 >gi|118462561|ref|YP_882292.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118163848|gb|ABK64745.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=2128 Score = 1685 bits (4364), Expect = 0.0, Method: Compositional matrix adjust. Identities = 963/1594 (61%), Positives = 1138/1594 (72%), Gaps = 42/1594 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLAS-RSVFEHRAVVVGASREQLIAG 59 V+SARSAEAL QA RL+ HV A+ P+DVG SL S R+VFEHRAVVVG R L G Sbjct 480 VVSARSAEALAGQARRLLDHVTADAQASPLDVGWSLVSTRAVFEHRAVVVGRERGALATG 539 Query 60 LAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LAGLA+G PG VG+ S GKTV+VFPGQG+Q +GMGR+LY VFA A D + Sbjct 540 LAGLASGRPGPATVVGRARSTGKTVLVFPGQGSQTLGMGRQLYERFEVFAGALDEAVAVV 599 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 D H RL +R+V+WGAD +LL STEFAQPALF EVA A+ GV PD VMGHSVGE+A Sbjct 600 DEHSRLSVREVMWGADPELLQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIA 659 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AA AGVL+L DAA LV ARG LM ALP GG MVAV A E +V PLLG GV IAA+N P+ Sbjct 660 AACVAGVLSLRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGGVSIAAVNGPD 719 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 +VV+SG Q A A+ADR A G RVH+LAVSHAFHS LMEPML+ FA AA ++ R P++ Sbjct 720 AVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAAAGIEPRPPRI 779 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 LVSN+TG+LAGP +G+ QYWVDHVRRPVRF D R ++ GA F+E GPG+ LT ++E Sbjct 780 PLVSNLTGQLAGPGYGTPQYWVDHVRRPVRFVDGVRLAESQGAGVFLEVGPGAALTSAVE 839 Query 360 QSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQ 419 QSL AM V + K RPE+ S L AA ++FT G V+WSA F G RRV LPTYAF Sbjct 840 QSLTSDRAMSVVTMPKGRPEVDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFA 899 Query 420 RRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRRFW + A G A+ A LGL EH LLGAV++RPDS VVLTGRLS A QPWLADH V Sbjct 900 RRRFWLSGDAVGSANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQPWLADHAV 959 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVG-AADESGHR 538 G VLFPGAGFVEL +RAGDEVGC ++EEL L+APL + G VQ+QVVV AA + G R Sbjct 960 AGTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVVADAAGQPGSR 1019 Query 539 AVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAY 598 +V+VYSR QS+ W L+AEG+L AA +LSVWPP AE+VD++ GY LA RGY Y Sbjct 1020 SVAVYSRVAQSE-WTLHAEGVLSEAAPAPAAELSVWPPADAEAVDVAGGYDDLAGRGYGY 1078 Query 599 GPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTE 658 GPAF+GL A+WRRG+E FAEV P +AGV+ R G+HP +LDA LHALG+A ++ E Sbjct 1079 GPAFRGLRAVWRRGAETFAEVELPEQAGVSTGRFGIHPVLLDAALHALGVADKR----LE 1134 Query 659 TRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 T LPF W+GVSLHA GA RVR R A AGA A+SV++ DA+G+PVL+VR LVTR ++AEQL Sbjct 1135 TVLPFSWQGVSLHAAGASRVRVRLAPAGAGAVSVELADASGVPVLSVRELVTRAVSAEQL 1194 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELE 778 AAV G+ + L+V WS I S P P+S V VWE Sbjct 1195 AAAVAVRSGSGEL--LDVAWSVIE-----PRNSLPDNPIS-----------EGVTVWEPA 1236 Query 779 SAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVW 838 + G + +V+AATH AL VLQS L + LVV T G VGL GED++DLA AAVW Sbjct 1237 AVDGAGPA---AVHAATHQALGVLQSRLAGEAGGVLVVSTRGAVGLPGEDVADLAGAAVW 1293 Query 839 GMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPA--PALLALP 896 G+ RSAQAE+PGR+VL+DTD ++D + + G GEPQL+VR G + RL PA ALL LP Sbjct 1294 GLVRSAQAEHPGRVVLVDTDGSLDLATVIGCGEPQLVVRDGVAYRARLRPAGRRALLELP 1353 Query 897 AAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQ 956 + WRLAAG GTLEDL +Q P A L GQVRV VAA GVNFRDV+ ALGMYPG Sbjct 1354 GPPAVWRLAAGDAGTLEDLAVQEHP--AAELAPGQVRVRVAAAGVNFRDVLVALGMYPGA 1411 Query 957 APPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAA 1016 A LGAEGAGVV E G VTD+AVGDAVMG G G A VD++LVTRVP GWS AQAA Sbjct 1412 A-QLGAEGAGVVTEVGAGVTDVAVGDAVMGIFGLVGSEAAVDRRLVTRVPPGWSMAQAAG 1470 Query 1017 VPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTL 1076 +PVVFLTA+YGL+ LA ++AG+ VL+HA TGGVGMAAVQLAR WG EVF TASRGKWDTL Sbjct 1471 IPVVFLTAYYGLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTL 1530 Query 1077 RAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMG 1136 RAMGFDD HI DSRT +FE+KF A G+DVVL+SLAGEF DASLRLL GGRF+EMG Sbjct 1531 RAMGFDDAHIADSRTLDFEQKFGAAPG--GMDVVLNSLAGEFNDASLRLLGPGGRFIEMG 1588 Query 1137 KTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRC 1196 KTD+RD +A +PGV+YRAFDL EAGP R+ MLAEV ELF L LPV +D RC Sbjct 1589 KTDLRDPDVVARAHPGVRYRAFDLMEAGPDRIAAMLAEVMELFAAGALTPLPVKAFDARC 1648 Query 1197 APAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHL 1256 A A+RF+S ARHIGKVVLTMP A L+ GT +ITGATG G LARHLV + V HL Sbjct 1649 AADAYRFVSAARHIGKVVLTMPDGPAG-LSGGTALITGATGMAGAALARHLVARHRVPHL 1707 Query 1257 VLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHA 1316 +L RRG+ A G AELAA+L AGA V V++CDV DR AVA + AQ+ Y P+R V HA Sbjct 1708 MLVGRRGEAAPGMAELAAELRGAGASVSVLSCDVGDRDAVAAMLAQVPARY-PLRSVFHA 1766 Query 1317 AGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGN 1376 AGVLDDAVI SLTP RIDTVLRAKVD AWNLH+ T DLDLS F + SS+A VG+PGQGN Sbjct 1767 AGVLDDAVIASLTPARIDTVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGAPGQGN 1826 Query 1377 YSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAE 1436 Y+AAN+FLD LA HR A GL +S+AWG+WE+P MTAHL RD ARMSR+GL+ +S + Sbjct 1827 YAAANSFLDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKARMSRAGLSALSTRQ 1886 Query 1437 AVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSS 1496 A++L D AL + PL V T LDRAAL A+ +A ALP L S LA RP RR ++ T S Sbjct 1887 ALDLLDDALLGEQPLVVGTRLDRAAL-AQHRA-ALPPLLSELAGRPARRMLEHTD--MVS 1942 Query 1497 KSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELR 1556 + L RL G+ +++ LV LVC AAAVLG +A DVDP F DLGFDSLTAVELR Sbjct 1943 LTGLRARLAGMNPEQRQAELVELVCGNAAAVLGHSTA-DVDPGDAFSDLGFDSLTAVELR 2001 Query 1557 NRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMS 1590 NRLK ATGLTL PTVIFDHPTP A+AE++ Q++ Sbjct 2002 NRLKIATGLTLSPTVIFDHPTPAALAEHLGGQLT 2035 >gi|560507|gb|AAA50928.1| pks002c [Mycobacterium tuberculosis] Length=950 Score = 1682 bits (4356), Expect = 0.0, Method: Compositional matrix adjust. Identities = 870/872 (99%), Positives = 872/872 (100%), Gaps = 0/872 (0%) Query 47 VVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELP 106 +VVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELP Sbjct 16 LVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELP 75 Query 107 VFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVL 166 VFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVL Sbjct 76 VFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVL 135 Query 167 PDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL 226 PDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL Sbjct 136 PDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL 195 Query 227 GEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFA 286 GEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFA Sbjct 196 GEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFA 255 Query 287 RVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFI 346 RVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFI Sbjct 256 RVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFI 315 Query 347 EAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGS 406 EAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGS Sbjct 316 EAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGS 375 Query 407 GGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRL 466 GGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRL Sbjct 376 GGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRL 435 Query 467 SLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQ 526 SLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQ Sbjct 436 SLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQ 495 Query 527 VVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISD 586 VVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISD Sbjct 496 VVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISD 555 Query 587 GYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHAL 646 GYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHAL Sbjct 556 GYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHAL 615 Query 647 GLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVR 706 GLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVR Sbjct 616 GLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVR 675 Query 707 SLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGS 766 SLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGS Sbjct 676 SLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGS 735 Query 767 DGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAG 826 DGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAG Sbjct 736 DGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAG 795 Query 827 EDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRL 886 EDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRL Sbjct 796 EDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRL 855 Query 887 SPAPALLALPAAESAWRLAAGGGGTLEDLVIQ 918 SPAPALLALPAAESAWRLAAGGGGTLEDLVI+ Sbjct 856 SPAPALLALPAAESAWRLAAGGGGTLEDLVIR 887 >gi|118617785|ref|YP_906117.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] gi|118569895|gb|ABL04646.1| polyketide synthase, Pks12 [Mycobacterium ulcerans Agy99] Length=4191 Score = 1679 bits (4349), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1612 (58%), Positives = 1126/1612 (70%), Gaps = 39/1612 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL AQA RL AHV+++ LD DVG SLA RS FEHRAVV+GA R+ L+AGL Sbjct 2524 VVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAGRSTFEHRAVVLGADRDGLLAGL 2583 Query 61 AGLAAGE-PGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LA E GA V G G+ GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V EL Sbjct 2584 DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEAFNTVVGEL 2643 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 DRHL PLR+VIWG D +LL++TEFAQPALFAVEVA + +L WGV PDFVMGHSVGEL+ Sbjct 2644 DRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLESWGVRPDFVMGHSVGELS 2703 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AAH AGVL+L +AA+LV ARGRLMQALP GGAM+AV A+E EV PLLG V IA IN P Sbjct 2704 AAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAVQATEQEVLPLLGAQVSIATINGPA 2763 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 SVVISGAQ A +A+A++ A GRRVH+LAVSHAFHSPLM+PM++EFA VA + P + Sbjct 2764 SVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAPTI 2823 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 G++SN+TG+LAG DFGSA YW HVR VRFADS R Q+ GA F+E GP GLT SIE Sbjct 2824 GIISNLTGQLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFLEVGPSIGLTASIE 2883 Query 360 QSLAPAEAM----VVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPT 415 + L+ A S L KDRPE S + A VF G V W AV S V+LPT Sbjct 2884 EVLSDAAVTNPVATASALRKDRPEPVSLVSALAGVFVAGTAVDWRAVVGQS--HFVELPT 2941 Query 416 YAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLA 475 YAF+RRRFW + G PADAAGLGL A EHALLGAVVE P S VVLTGRLSLA Q WLA Sbjct 2942 YAFERRRFWLS-GDAVPADAAGLGLQAGEHALLGAVVELPASGGVVLTGRLSLAAQGWLA 3000 Query 476 DHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADES 535 DH V GVV+FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ G V VQVVVG+ D+S Sbjct 3001 DHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDS 3060 Query 536 GHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERG 595 G RAVSVYSRGD W+L+AEG LG + E DLS WPP GA V+ +DGY QLAERG Sbjct 3061 GARAVSVYSRGDAGSDWVLHAEGSLGSGSPEPATDLSTWPPVGAVEVENADGYQQLAERG 3120 Query 596 YAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQ- 654 Y YGPAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ LA + Sbjct 3121 YGYGPAFRGLNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDAALHAVILASDGADD 3180 Query 655 ---ASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTR 711 +PF W+GV+LHA GA VRAR A AG A+S+++ D GLPVL+V S++ R Sbjct 3181 FGVPEGSVLVPFAWQGVTLHAAGASAVRARIAPAGPSAVSIELSDGLGLPVLSVASMLAR 3240 Query 712 PITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVS-WADFCAGSDGD- 769 P+T +QLRAAV+ AG G V W + + P PV W + D D Sbjct 3241 PVTDQQLRAAVSGAGPDRLFG---VDW------TAQPSAELQPVPVRIWGTVESEGDDDP 3291 Query 770 -ASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ASVV + QA VV VYAAT LEVL+SWL D A L++ T G V L ED Sbjct 3292 GASVVFESVP----QAGEVVAGVYAATAAVLEVLRSWLSRDGAGQLIITTRGAVALPDED 3347 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPR 885 ++DLA +AVWG+ RSAQ E+PGRIVL+DTDA +D +A V GEPQ+L R G V+ R Sbjct 3348 VTDLAGSAVWGLVRSAQTEHPGRIVLVDTDAQLDEHAVAAVLAAGEPQVLWRNGEVYTAR 3407 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A A L +P + WRL GT E+L ++P P+ A LQ G VRVA++A+ NF Sbjct 3408 VHGSRAVAGLLVPPGDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANF 3467 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLV 1002 RDV+ ALG+YP +G EGAGVV+ET AVGD V+G F G G +A+ D +L+ Sbjct 3468 RDVMIALGLYPDPDAAMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGTGTIAITDHRLL 3527 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 ++P GWS AA VVF TA+Y L DLA ++ G+ +L+HA TGGVGMAAVQLAR WG+ Sbjct 3528 VKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAATGGVGMAAVQLARHWGL 3587 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFD+DHIGDSR+ EFE+KF A T GRG+DVVLDSLAGEFVDAS Sbjct 3588 EVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAATGGRGMDVVLDSLAGEFVDAS 3647 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIR+A +A + GV+YRAFDL EAGP + ++LAE+ LF Sbjct 3648 LRLVAPGGVFLEMGKTDIREAAVVAQQHTGVRYRAFDLFEAGPDHIAQILAELAALFSED 3707 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH+GKVVLTMP D A GTV+ITG TG G Sbjct 3708 VLRPLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGGTGMAGSA 3763 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 LARH+V +GVR LVL SRRG A GAAELA +L+ GA+VQVVACD ADRAA+A L A Sbjct 3764 LARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQVVACDAADRAALAKLIAD 3823 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ VIH AG LDDAV+TSLTP+RI+TVLRAKVDAAWNLH+ T D+DLS F + Sbjct 3824 IPMQH-PLSAVIHTAGALDDAVVTSLTPERIETVLRAKVDAAWNLHELTRDMDLSAFVMF 3882 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQGNY+AAN+FLDGLA HRQA GL ISL WGLW+Q MT L++ D Sbjct 3883 SSMAGLVGSSGQGNYAAANSFLDGLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFK 3942 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R +R G+ MS EA+ L D A+ + P + +D AAL + G LP +F L P Sbjct 3943 RFARDGIVAMSSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAP 4002 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSAL QRL GL DEQ +L+ LV A VLG S + +DPD F Sbjct 4003 TRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDAIDPDRAF 4062 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRP 1594 +LGFDSLTAVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ G+ P Sbjct 4063 QELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMHRELVGASP 4114 Score = 1351 bits (3496), Expect = 0.0, Method: Compositional matrix adjust. Identities = 818/1619 (51%), Positives = 1036/1619 (64%), Gaps = 62/1619 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL AQA RL AHV+++ LD DVG SLA RS FEHRAVV+GA R+ L+AGL Sbjct 483 VVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAGRSTFEHRAVVLGADRDGLLAGL 542 Query 61 AGLAAGE-PGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LA E GA V G G+ GKTV VFPGQG+Q IGMG EL PVFA+ ++ Sbjct 543 DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTAPVFARHIESCGQAF 602 Query 120 DRHLRLPLRDVIWGA-DADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGEL 178 + L DV+ GA A LD + QP LFAV V+ + + GV PD V+GHS GE+ Sbjct 603 AEFVDWSLLDVLRGAAGAPGLDRIDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEI 662 Query 179 AAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAI 235 AAA+ AG L+L DAA +V R +L+ L G MV+VA E + LL G+ V IAAI Sbjct 663 AAAYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAI 722 Query 236 NAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAR 295 N P +VV+SG AA + + A + R ++ V +A HS +E + + V A ++ Sbjct 723 NGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL 782 Query 296 EPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLT 355 + S+VTG A+YW ++R+ V+F + R G FIE+ P L Sbjct 783 SSRTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAVRSACGHGYRTFIESSPHPALI 842 Query 356 GSIEQSL------APAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGR 409 IE + + A+ +VV LG++ L L +A F GV V W G+G Sbjct 843 AGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAAAAFVAGVNVDWRGPLDGAG-- 900 Query 410 RVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLA 469 V+LPTYAF++RRFW + G DA+GLGL A HALLGAVVE P+S VVLTGRL+L Sbjct 901 LVELPTYAFEKRRFWLS-GEGVSVDASGLGLSAGGHALLGAVVELPESGGVVLTGRLALG 959 Query 470 DQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVV 529 WLADH V+GVV+FPG GFVEL IRA DEVGC+++ EL L PLV+ V VQVVV Sbjct 960 AHGWLADHAVSGVVVFPGTGFVELAIRAVDEVGCSVVNELTLRTPLVLPASGSVAVQVVV 1019 Query 530 GAADESGHRAVSVYSRGDQSQG------WLLNAEGMLGVAAAETPMDLSVWPPEGAESVD 583 GAA +S R+VS+YSR D W+ +AEG LG +A+ DLS WPP GA +VD Sbjct 1020 GAAADSAERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAIAVD 1079 Query 584 ISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVL 643 ++DGY +L RGY YGPAF+GL A+W RG ELFAE P AG + G+HPA+LDA L Sbjct 1080 VADGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAG-STSGFGVHPALLDAAL 1138 Query 644 HALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVL 703 H +A + LPF W+GVSLHA GA VR R A G ++SV++ D GLPVL Sbjct 1139 HTAVIA----NPDADLVLPFSWQGVSLHAAGAASVRVRIAPVGPSSVSVELADDLGLPVL 1194 Query 704 TVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFC 763 +V+++V RP++ +Q+RA V+A+G EVVW+P++V A A PA + Sbjct 1195 SVKAMVARPVSEQQMRAVVSASG---PDRLFEVVWTPMTV----AATDAAPAYELFESIA 1247 Query 764 AGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVG 823 A DGD + Y TH AL +QSWL + LVV T G + Sbjct 1248 A--DGDP-----------------LSGTYQRTHQALAAVQSWLTEHDSGVLVVATRGAMA 1288 Query 824 LAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGT 880 LAGED++DLA AAVWG+ RSAQ ENPGR+VL+D+DAAVDA+ +A GEPQ+++R G Sbjct 1289 LAGEDVTDLAGAAVWGLVRSAQTENPGRLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQ 1348 Query 881 VHAPRLSPAPAL--LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAA 938 + R+ + A + +P + WRL GT E+L ++P P APL GQVRVA+ A Sbjct 1349 PYTARVHASRAADGILVPPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRA 1408 Query 939 VGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVV 997 + NFRD++ LGM+ A +G EGAGVV+E GPEVT+ AVGDAV GF G+G L Sbjct 1409 IAANFRDIMITLGMFTHDAL-IGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLVAG 1467 Query 998 DQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLA 1057 D +L+ P WS+A+AAA+ VF TA+Y LA ++ G+ VL+HA TGGVGMAAVQLA Sbjct 1468 DVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAATGGVGMAAVQLA 1527 Query 1058 RQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGE 1117 R G+EV+ TAS+GKWD LRAMGFD+DHI DSR+ EFEEKF VT GR VDVVLDSLAGE Sbjct 1528 RHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFEEKFREVTGGRSVDVVLDSLAGE 1587 Query 1118 FVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRE 1177 FVDASLRLL GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + ++ Sbjct 1588 FVDASLRLLGPGGVFLEMGKTDIRDPGVIAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAG 1647 Query 1178 LFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATG 1237 LFD L LPVT +DVR APAA R++SQARH+GKVV+TMP+ L GTV+ITG TG Sbjct 1648 LFDAGVLRPLPVTAFDVRRAPAALRYLSQARHVGKVVMTMPADQGGALGGGTVLITGGTG 1707 Query 1238 AVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVA 1297 G LARHLV +GV HLVL SRRG A GA EL A+L+ AGA+V+VVACD ADR A+A Sbjct 1708 MAGSALARHLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPALA 1767 Query 1298 GLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLS 1357 + A+ + P+ V+HA GVLDDAVI+SLTP+R+DTVLRAKVDAAWNLH+ T DLDLS Sbjct 1768 KVIAENPAQR-PLSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAWNLHELTRDLDLS 1826 Query 1358 MFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLS 1417 F + SS+A VGS GQ NY+AAN F+DGLAAHR+A GL ISL WGLW+Q MT + Sbjct 1827 AFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRAHGLPAISLGWGLWDQASDMTGGMD 1886 Query 1418 SRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSG 1477 + D AR+ R G+ +S EA+ELFD AL ++ +D AAL RA A A+P +FS Sbjct 1887 AADRARLGREGVLALSSDEAMELFDTALIVNQAFLAPARIDLAAL--RAHAVAVPPMFSD 1944 Query 1478 LARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVD 1537 L P RRQID SKSALA RLHGL EQ +++ LV A VLG + E +D Sbjct 1945 LVSAPTRRQIDAALATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAID 2004 Query 1538 PDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTE 1596 PD F +LGFDSLTAVE+RNR+KT TGL+L PT+IFD+PTP +A Y+ +++G+ P E Sbjct 2005 PDKAFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELAGA-PQE 2062 >gi|31793231|ref|NP_855724.1| polyketide synthase pks12 [Mycobacterium bovis AF2122/97] gi|31618823|emb|CAD96927.1| Probable polyketide synthase pks12 [Mycobacterium bovis AF2122/97] Length=4151 Score = 1670 bits (4325), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1137/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAA LGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAASLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA+++ G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT+ L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSALA RLHGL DEQ +L+ LV A VLG S E +DPD F DLGFDSLT Sbjct 3973 AAAKSKSALAHRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQDLGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL+L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLSLSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1360 bits (3521), Expect = 0.0, Method: Compositional matrix adjust. Identities = 838/1609 (53%), Positives = 1051/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT+ L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|340626668|ref|YP_004745120.1| polyketide synthase PKS8 [Mycobacterium canettii CIPT 140010059] gi|340004858|emb|CCC44003.1| polyketide synthase PKS8 [Mycobacterium canettii CIPT 140010059] Length=2105 Score = 1668 bits (4319), Expect = 0.0, Method: Compositional matrix adjust. Identities = 948/1597 (60%), Positives = 1135/1597 (72%), Gaps = 58/1597 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSL-ASRSVFEHRAVVVGASREQLIAG 59 V+SARS +AL QA RL+A V ANP LDPIDVG SL +R++FEHRAVVVGA R L+AG Sbjct 477 VLSARSEQALAGQAQRLLAFVAANPDLDPIDVGWSLVKTRAMFEHRAVVVGADRGALLAG 536 Query 60 LAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LA LAAGE GAGVAVG+ SVGKTV VFPGQGAQ +GMG +LY ELP+FA AFDAVA+EL Sbjct 537 LAALAAGESGAGVAVGRARSVGKTVFVFPGQGAQWVGMGAQLYAELPLFALAFDAVAEEL 596 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 DRHLRLPLR V+W D LL STEFAQPALFA+EVA +L+ WG+ PDF++GHSVGE+A Sbjct 597 DRHLRLPLRKVLWEGDEALLTSTEFAQPALFAIEVALATLLQHWGISPDFLIGHSVGEIA 656 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AAH AGVL+L DAA LV ARGRLM LPAGG MV VAASE+EV P+L +G +AA+NAP Sbjct 657 AAHLAGVLSLTDAAGLVAARGRLMAELPAGGVMVVVAASEEEVLPVLVDGANLAAVNAPH 716 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 SVV+SG +AA + IAD FA +GRRVH+LAVSHAFHS LMEPML EF R+AA + +P++ Sbjct 717 SVVVSGCEAAVSDIADHFARRGRRVHRLAVSHAFHSLLMEPMLAEFTRIAAGISVSKPRI 776 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 LVSNVTG++AG +G QYWV+H RRPVRFA+ + L +GAT F+E GPG GLT +E Sbjct 777 PLVSNVTGQMAGAGYGDGQYWVEHARRPVRFAEGVQLLNAVGATRFVEVGPGGGLTALVE 836 Query 360 QSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQ 419 QSL EA+ V+M+ ++ PE++S LGA +FT G + W AVF GS GRR++LPTYAFQ Sbjct 837 QSLPLGEALSVAMMRREHPEVSSVLGAVATLFTAGAQMDWPAVF-GSPGRRIELPTYAFQ 895 Query 420 RRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 R+R+W P + G AD +G+GL A H LLGAVVE+PDSD VVLTGRLS+ +Q WLADHV+ Sbjct 896 RQRYWLPPTSAGSADISGVGLLAARHGLLGAVVEQPDSDVVVLTGRLSVGEQRWLADHVI 955 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GVVL GA FVEL +RA D+V C ++EEL + PLV+ P VG VV E G R Sbjct 956 AGVVLLAGAAFVELALRAADQVDCGVVEELTVVTPLVL-PTVGGVQLQVVVGVGEMGQRP 1014 Query 540 VSVYSRGDQS-QGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAY 598 VS+YSR +S GW+L+A G+LG A DLSVWPP GA VD+ Y + AE GY Y Sbjct 1015 VSIYSRNAESDSGWVLHARGVLGAKAVAPAADLSVWPPLGAAPVDVDGAYQRFAELGYEY 1074 Query 599 GPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTE 658 G AFQGL A+WRR SELFA+V P + V + G+HP VLDA LHA+G+ E+ Sbjct 1075 GRAFQGLTAMWRRESELFADVAVPDDVDVTLSGFGIHPLVLDAALHAMGMVGEQAA---- 1130 Query 659 TRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 T LPF W+GVSLHA GA RVRAR A AG +SV++ D GLPVL+V++LV R +++ QL Sbjct 1131 TMLPFSWQGVSLHAAGASRVRARIAPAGDGTVSVELADQAGLPVLSVQALVMRSVSS-QL 1189 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELE 778 +A AA A+ +G LEV W P+ + A +D A +VVWELE Sbjct 1190 LSAAVAAADAAGRGLLEVAWLPVEL--------------------AHNDISADLVVWELE 1229 Query 779 SAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVW 838 S VG VY+ATH L LQSWL +RA LVVLT G V G+D ++LA AAVW Sbjct 1230 S----FQDGVGPVYSATHRVLVALQSWLAQERAGRLVVLTQGSV---GQDATNLAGAAVW 1282 Query 839 GMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLS---PAPALLAL 895 G+ RSAQAE+PGR++L+D+D ++D + G GE QL++R GT +A RL+ P P +L L Sbjct 1283 GLVRSAQAEHPGRVMLVDSDGSMDVGDVIGCGEEQLMIRNGTAYAARLAQLRPQP-ILQL 1341 Query 896 PAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPG 955 P S WRL AGG GTLEDL + CP + L GQVR+ V A+GVNFRDV+ ALGMYPG Sbjct 1342 PDTNSGWRLVAGGAGTLEDLTLASCPAKE--LAPGQVRIEVRALGVNFRDVLVALGMYPG 1399 Query 956 QAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAA 1015 A LGAEGAGVV E GP VT LAVGD VMG LG AG AVVD +LV ++P W AA Sbjct 1400 AA-ELGAEGAGVVTEVGPGVTGLAVGDPVMGLLGVAGSEAVVDARLVVKLPNRWPLTDAA 1458 Query 1016 AVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDT 1075 VPVVFLTA+Y L LA+++ GESVL+HA GGVGMAAVQLAR WG+EVF TASRGKWDT Sbjct 1459 GVPVVFLTAYYALRVLAQVQPGESVLVHAAAGGVGMAAVQLARLWGLEVFATASRGKWDT 1518 Query 1076 LRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEM 1135 L MG D+ H+ DSRT FEE F TEGRGVDVVL+SLAGEF DASLRLL RGGRF+EM Sbjct 1519 LHTMGCDNTHVADSRTLAFEETFWLTTEGRGVDVVLNSLAGEFTDASLRLLPRGGRFIEM 1578 Query 1136 GKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVR 1195 GKTD+RDAQ +A ++PGV YRAFDL EAGP R+ +MLAE+ ELF T LHRLPV +WDVR Sbjct 1579 GKTDVRDAQVVAQDHPGVAYRAFDLMEAGPQRIAQMLAELVELFKTEALHRLPVKSWDVR 1638 Query 1196 CAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRH 1255 A A+RF+SQARH+GKVVLTMP D A GTV+ITG TG G +ARHLV YGVR Sbjct 1639 HAREAYRFLSQARHVGKVVLTMP----DAWAAGTVLITGGTGMAGSAVARHLVSRYGVRQ 1694 Query 1256 LVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIH 1315 +VLASR G+ E A L +L AGA+VQVV+CDVADR AVAGL A P + V H Sbjct 1695 VVLASRAGEHTESVAALVDELGSAGARVQVVSCDVADRDAVAGLVAS----QPDLTAVFH 1750 Query 1316 AAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQG 1375 AAGVLDDAVIT LTPDR+D VLRAKVD AWNLH+ T LD+S F L SS+A VG+PGQ Sbjct 1751 AAGVLDDAVITGLTPDRVDKVLRAKVDGAWNLHELTRHLDVSAFVLFSSMAGIVGAPGQA 1810 Query 1376 NYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPA 1435 NY+AANAFLDGLAA+R++ GLA +S+AWGLWEQ MT HL RD RMSR GLAP+ Sbjct 1811 NYAAANAFLDGLAAYRRSRGLAALSVAWGLWEQASAMTEHLGERDRVRMSRVGLAPLPTN 1870 Query 1436 EAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATS 1495 +A+ DAAL D P+ VA A LPALFS L P RR ID G Sbjct 1871 QAMGFLDAALLADRPVVVAA----RLDRAALAGAELPALFSQLVAGPIRRIID--GADEV 1924 Query 1496 SKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVEL 1555 S S LA RLHGL +++ L LVC AA VLG S ++D F DLGFDSLTAVEL Sbjct 1925 SGSGLASRLHGLTPEQRHRELTELVCSNAAIVLGH-SGTEIDAHKAFQDLGFDSLTAVEL 1983 Query 1556 RNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS 1592 RNRLKTATGLTLPPT+IFD+PT +AE++ Q++ + Sbjct 1984 RNRLKTATGLTLPPTLIFDYPTAAELAEHLDIQLANA 2020 >gi|183983026|ref|YP_001851317.1| polyketide synthase, Pks12 [Mycobacterium marinum M] gi|183176352|gb|ACC41462.1| polyketide synthase, Pks12 [Mycobacterium marinum M] Length=4187 Score = 1666 bits (4314), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1612 (58%), Positives = 1126/1612 (70%), Gaps = 39/1612 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL AQA RL AHV+++ LD DVG SLA RS FEHRAVV+G R+ L+AGL Sbjct 2520 VVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAGRSTFEHRAVVLGVDRDGLLAGL 2579 Query 61 AGLAAGE-PGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LA E GA V G G+ GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V EL Sbjct 2580 DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEAFNTVVGEL 2639 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 DRHL PLR+VIWG D +LL++TEFAQPALFAVEVA + +L WGV PDFVMGHSVGEL+ Sbjct 2640 DRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLESWGVRPDFVMGHSVGELS 2699 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AAH AGVL+L +AA+LV ARGRLMQALP GGAM+AV A+E EV PLLG V IAAIN P Sbjct 2700 AAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAVQATEQEVLPLLGAQVSIAAINGPA 2759 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 SVVISGAQ A +A+A++ A GRRVH+LAVSHAFHSPLM+PM++EFA VA + P + Sbjct 2760 SVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAPTI 2819 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 G++SN+TG+LAG DFGSA YW HVR VRFADS R Q+ GA F+E GP SGLT SIE Sbjct 2820 GIISNLTGQLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFLEVGPSSGLTASIE 2879 Query 360 QSLAPAEAM----VVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPT 415 + L+ A S L KDRPE S + A VF G V W AV S V+LPT Sbjct 2880 EVLSDAAVTNPVATASALRKDRPEPVSLVSAVAGVFVAGTAVDWRAVVGQS--NFVELPT 2937 Query 416 YAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLA 475 YAF+RRRFW + G ADAAGLGL A EHALLGAVVE P S VVLTGRLSLA Q WLA Sbjct 2938 YAFERRRFWLS-GDAVAADAAGLGLQAGEHALLGAVVELPASGGVVLTGRLSLAAQGWLA 2996 Query 476 DHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADES 535 DH V GVV+FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ G V VQVVVG+ D+S Sbjct 2997 DHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDS 3056 Query 536 GHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERG 595 G RAVSVYSRGD W+L+AEG LG + E DLS WPP GA V+ +DGY QLAERG Sbjct 3057 GARAVSVYSRGDAGSDWVLHAEGSLGSGSPEPATDLSTWPPVGAVEVENADGYQQLAERG 3116 Query 596 YAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQ- 654 Y YGPAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ LA + Sbjct 3117 YGYGPAFRGLNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDAALHAVILASDGADD 3176 Query 655 ---ASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTR 711 +PF W+GV+LHA GA VRAR A AG A+S+++ D GLPVL+V S++ R Sbjct 3177 FGVPEGSVLVPFAWQGVTLHAAGASAVRARIAPAGPSAVSIELSDGLGLPVLSVASMLAR 3236 Query 712 PITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVS-WADFCAGSDGD- 769 P+T +QLRAAV+ AG G V W + + P PV W + D D Sbjct 3237 PVTDQQLRAAVSGAGPDRLFG---VDW------TAQPSAELQPVPVRIWGAVESEGDDDP 3287 Query 770 -ASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ASVV + QA VV VYAAT LEVL+SWL D A LV+ T G V L ED Sbjct 3288 GASVVFESVP----QAGEVVAGVYAATAAVLEVLRSWLSRDGAGQLVITTRGAVALPDED 3343 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPR 885 ++DLA +AVWG+ RSAQ E+PGRIVL+DTDA +D +A V GEPQ+L R G V+ R Sbjct 3344 VTDLAGSAVWGLVRSAQTEHPGRIVLVDTDAQLDEHAVAAVLAAGEPQVLWRNGEVYTAR 3403 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A A L +P + WRL GT E+L ++P P+ A LQ G VRVA++A+ NF Sbjct 3404 VHGSRAVAGLLVPPGDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANF 3463 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLV 1002 RDV+ ALG+YP +G EGAGVV+ET AVGD V+G F G G +A+ D +L+ Sbjct 3464 RDVMIALGLYPDPDAAMGVEGAGVVVETASTDGRFAVGDRVVGLFPEGTGTIAITDHRLL 3523 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 ++P GWS AA VVF TA+Y L DLA ++ G+ +L+HA TGGVGMAAVQLAR WG+ Sbjct 3524 VKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAATGGVGMAAVQLARHWGL 3583 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFD+DHIGDSR+ EFE+KF A T GRG+DVVLDSLAGEFVDAS Sbjct 3584 EVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAATGGRGMDVVLDSLAGEFVDAS 3643 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIR+A +A + GV+YRAFDL EAGP + ++LAE+ LF Sbjct 3644 LRLVAPGGVFLEMGKTDIREAAVVAQQHTGVRYRAFDLFEAGPDHIAQILAELAALFSED 3703 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH+GKVVLTMP D A GTV+ITG TG G Sbjct 3704 ALRPLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGGTGMAGSA 3759 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 LARH+V +GVR LVL SRRG A GAAELA +L+ GA+VQVVACD ADRAA+A L A Sbjct 3760 LARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQVVACDAADRAALAKLIAD 3819 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ VIH AG LDDAV+TSLTP+R++TVLRAKVDAAWNLH+ T D+DLS F + Sbjct 3820 IPVQH-PLSAVIHTAGALDDAVVTSLTPERMETVLRAKVDAAWNLHELTRDMDLSAFVMF 3878 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQGNY+AAN+FLDGLA HRQA GL ISL WGLW+Q MT L++ D Sbjct 3879 SSMAGLVGSSGQGNYAAANSFLDGLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFK 3938 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R +R G+ MS EA+ L D A+ + P + +D AAL + G LP +F L P Sbjct 3939 RFARDGIVAMSSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAP 3998 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSAL QRL GL DEQ +L+ LV A VLG S + +DPD F Sbjct 3999 TRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDAIDPDRAF 4058 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRP 1594 +LGFDSLTAVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ G+ P Sbjct 4059 QELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMHRELVGASP 4110 Score = 1361 bits (3523), Expect = 0.0, Method: Compositional matrix adjust. Identities = 824/1616 (51%), Positives = 1045/1616 (65%), Gaps = 60/1616 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL AQA RL AHV+++ LD DVG SLA RS FEHRAVV+G R+ L+AGL Sbjct 483 VVSAKSGSALGAQAARLAAHVRSHDELDVADVGWSLAGRSTFEHRAVVLGVDRDGLLAGL 542 Query 61 AGLAAGE-PGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LA E GA V G G+ GKTV VFPGQG+Q IGMG EL PVFA+ ++ Sbjct 543 DELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTAPVFARHIESCGQAF 602 Query 120 DRHLRLPLRDVIWGA-DADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGEL 178 + L DV+ GA A LD + QP LFAV V+ + + GV PD V+GHS GE+ Sbjct 603 AEFVDWSLLDVLRGAAGAPGLDRVDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEI 662 Query 179 AAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAI 235 AAA+ AG L+L DAA +V R +L+ L G MV+VA E + LL G+ V IAAI Sbjct 663 AAAYVAGALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAI 722 Query 236 NAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAR 295 N P +VV+SG AA + + A + R ++ V +A HS +E + + V A ++ Sbjct 723 NGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL 782 Query 296 EPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLT 355 + S+VTG A+YW ++R+ V+F + R G FIE+ P L Sbjct 783 SSRTAFFSSVTGSRLDTAELDAEYWYRNIRQTVQFDQAVRSACGHGYRTFIESSPHPALI 842 Query 356 GSIEQSL------APAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGR 409 IE + + A+ +VV LG++ L L +A F GV V W G+G Sbjct 843 AGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAAAAFVAGVNVDWRGPLDGAG-- 900 Query 410 RVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLA 469 V+LPTYAF++RRFW + G DA+GLGL A HALLGAVVE P+S VVLTGRL+L Sbjct 901 LVELPTYAFEKRRFWLS-GEGVSVDASGLGLSAGGHALLGAVVELPESGGVVLTGRLALG 959 Query 470 DQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVV 529 WLADH V+GVV+FPG GFVEL IRAGDEVGC+++ EL L PLV+ V VQVVV Sbjct 960 AHGWLADHAVSGVVVFPGTGFVELAIRAGDEVGCSVVNELTLRTPLVLPASGSVAVQVVV 1019 Query 530 GAADESGHRAVSVYSRGDQSQG--WLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDG 587 GAA +S R+VS+YSR D G W+ +AEG LG +A+ DLS WPP GA +VD++DG Sbjct 1020 GAAADSAERSVSIYSRTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAIAVDVADG 1079 Query 588 YAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALG 647 Y +L RGY YGPAF+GL A+W RG ELFAEV P AG + G+HPA+LDA LH Sbjct 1080 YERLDARGYGYGPAFRGLTAMWARGEELFAEVRLPEAAG-STSGFGVHPALLDAALHTAV 1138 Query 648 LAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRS 707 +A E LPF W+GVSLHA GA VR R A G ++SV++ D GLPVL+V++ Sbjct 1139 IA----NPDAELVLPFSWQGVSLHAAGAASVRVRIAPVGPSSVSVELADDLGLPVLSVKA 1194 Query 708 LVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSD 767 +V RP++ +Q+RA V+A+G EVVW+P++V A +AP Sbjct 1195 MVARPVSEQQMRAVVSASG---PDRLFEVVWTPMTVA---ATDAAP-------------- 1234 Query 768 GDASVVVWEL-ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAG 826 +EL ES + + G+ Y TH AL +QSWL + LVV T G + LAG Sbjct 1235 ------AYELFESVAAEGDPLSGT-YQRTHQALAAVQSWLTEHDSGVLVVATRGAMALAG 1287 Query 827 EDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHA 883 ED++DLA AAVWG+ RSAQ ENPGR+VL+D+DAAVDA+ +A GEPQ+++R G + Sbjct 1288 EDVTDLAGAAVWGLVRSAQTENPGRLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYT 1347 Query 884 PRLSPAPAL--LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGV 941 R+ + A + +P + WRL GT E+L ++P P APL GQVRVA+ A+ Sbjct 1348 ARVHASRAADGILVPPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAA 1407 Query 942 NFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQ 1000 NFRD++ LGM+ A +G EGAGVV+E GPEVT+ AVGDAV GF G+G L D + Sbjct 1408 NFRDIMITLGMFTHDAL-IGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLVAGDVR 1466 Query 1001 LVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQW 1060 L+ P WS+A+AAA+ VF TA+Y LA ++ G+ VL+HA TGGVGMAAVQLAR Sbjct 1467 LLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAATGGVGMAAVQLARHL 1526 Query 1061 GVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVD 1120 G+EV+ TAS+GKWD LRAMGFD+DHI DSR+ EFEEKF VT GRGVDVVLDSLAGEFVD Sbjct 1527 GLEVYATASKGKWDILRAMGFDEDHISDSRSLEFEEKFREVTGGRGVDVVLDSLAGEFVD 1586 Query 1121 ASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFD 1180 ASLRLL GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + ++ LFD Sbjct 1587 ASLRLLGPGGVFLEMGKTDIRDPGVIAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFD 1646 Query 1181 TRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVG 1240 L LPVT +DVR APAA R++SQARHIGKVV+TMP+ L GTV+ITG TG G Sbjct 1647 AGVLRPLPVTAFDVRRAPAALRYLSQARHIGKVVMTMPADQGGALGGGTVLITGGTGMAG 1706 Query 1241 GVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLF 1300 LARHLV +GV HLVL SRRG A GA EL A+L+ AGA+V+VVACD ADR A+A + Sbjct 1707 SALARHLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPALAKVI 1766 Query 1301 AQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFA 1360 A++ + P+ V+HA GVLDDAVI+SLTP+R+DTVLRAKVDAAWNLH+ T DLDLS F Sbjct 1767 AEIPAQR-PLSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAWNLHELTRDLDLSAFV 1825 Query 1361 LCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRD 1420 + SS+A VGS GQ NY+AAN F+DGLAAHR+A GL ISL WGLW+Q MT + + D Sbjct 1826 MFSSMAGVVGSSGQANYAAANTFVDGLAAHRRAHGLPAISLGWGLWDQASDMTGGMDAAD 1885 Query 1421 LARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLAR 1480 AR+ R G+ +S EA+ELFD AL ++ +D AAL RA A A+P +FS L Sbjct 1886 RARLGREGVLALSSDEAMELFDTALIVNQAFLAPARIDLAAL--RAHAVAVPPMFSDLVS 1943 Query 1481 RPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDT 1540 P RRQ+DD A SKSALA RLHGL EQ +++ LV A VLG + E +DPD Sbjct 1944 APTRRQVDDALAAAKSKSALAHRLHGLPEPEQHAVVLDLVRSHIATVLGTITPEAIDPDK 2003 Query 1541 EFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTE 1596 F +LGFDSLTAVE+RNR+KT TGL+L PT+IFD+PTP +A Y+ +++G+ P E Sbjct 2004 AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELAGA-PQE 2058 >gi|289554169|ref|ZP_06443379.1| polyketide synthase Pks12 [Mycobacterium tuberculosis KZN 605] gi|289438801|gb|EFD21294.1| polyketide synthase Pks12 [Mycobacterium tuberculosis KZN 605] Length=2730 Score = 1663 bits (4306), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 1078 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 1137 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 1138 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 1197 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 1198 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 1257 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 1258 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 1317 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 1318 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 1377 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 1378 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 1437 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 1438 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 1495 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 1496 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 1553 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 1554 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 1613 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 1614 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 1673 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 1674 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 1733 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 1734 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 1793 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 1794 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 1839 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 1840 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 1896 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 1897 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 1956 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 1957 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 2016 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 2017 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 2076 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 2077 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 2136 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 2137 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 2196 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 2197 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 2256 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 2257 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 2312 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 2313 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 2371 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 2372 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 2431 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 2432 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 2491 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 2492 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 2551 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 2552 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 2611 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 2612 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 2657 Score = 692 bits (1787), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/626 (61%), Positives = 460/626 (74%), Gaps = 8/626 (1%) Query 967 VVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAW 1025 +V+E GP VT+ +VGD+V GF G+G L D +L+ +P WS+A+AAA+ VF TA+ Sbjct 1 MVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAY 60 Query 1026 YGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDH 1085 Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+GKWDTLRAMGFDDDH Sbjct 61 YAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDH 120 Query 1086 IGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQE 1145 I DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG FLEMGKTDIRD Sbjct 121 ISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV 180 Query 1146 IAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMS 1205 IA YPGV+YRAFDL E G RM + + E+ LF L LPVTT+DVRCAPAA R++S Sbjct 181 IAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRCAPAALRYLS 240 Query 1206 QARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDR 1265 QARH GKVV+ MP + A GTV+ITG TG G +ARH+V +GVR+LVL SRRG Sbjct 241 QARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPD 296 Query 1266 AEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVI 1325 A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ GVIH AG LDDAV+ Sbjct 297 APGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLSGVIHTAGALDDAVV 355 Query 1326 TSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLD 1385 SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS GQ NY+AAN+FLD Sbjct 356 MSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD 415 Query 1386 GLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAAL 1445 LAAHR+A GL ISL WGLW+Q MT L + DLAR+ R G+ +S AEA+ELFD A+ Sbjct 416 ALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDTAM 475 Query 1446 AIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLH 1505 +D P +D AL RA A A+P +FS LA P RRQ+DD+ A SKSALA RLH Sbjct 476 IVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLH 533 Query 1506 GLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGL 1565 GL EQ +L+GLV L A VLG + E +DPD F DLGFDSLTAVE+RNRLK+ATGL Sbjct 534 GLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGL 593 Query 1566 TLPPTVIFDHPTPTAVAEYVAQQMSG 1591 +L PT+IFD+PTP +A Y+ +++G Sbjct 594 SLSPTLIFDYPTPNRLASYIRTELAG 619 >gi|339298599|gb|AEJ50709.1| polyketide synthase Pks12 [Mycobacterium tuberculosis CCDC5180] Length=2617 Score = 1662 bits (4305), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 965 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 1024 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 1025 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 1084 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 1085 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 1144 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 1145 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 1204 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 1205 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 1264 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 1265 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 1324 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 1325 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 1382 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 1383 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 1440 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 1441 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 1500 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 1501 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 1560 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 1561 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 1620 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 1621 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 1680 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 1681 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 1726 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 1727 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 1783 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 1784 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 1843 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 1844 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 1903 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 1904 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 1963 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 1964 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 2023 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 2024 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 2083 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 2084 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 2143 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 2144 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 2199 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQV+ACD ADRAA+A + A + ++ P+ Sbjct 2200 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVLACDAADRAALAKVIADIPVQH-PLS 2258 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 2259 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 2318 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 2319 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 2378 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 2379 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 2438 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 2439 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 2498 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 2499 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 2544 Score = 567 bits (1461), Expect = 7e-159, Method: Compositional matrix adjust. Identities = 312/513 (61%), Positives = 375/513 (74%), Gaps = 7/513 (1%) Query 1079 MGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKT 1138 MGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG FLEMGKT Sbjct 1 MGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKT 60 Query 1139 DIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAP 1198 DIRD IA YPGV+YRAFDL E G RM + + E+ LF L LPVTT+DVRCAP Sbjct 61 DIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRCAP 120 Query 1199 AAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVL 1258 AA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V +GVR+LVL Sbjct 121 AALRYLSQARHTGKVVMLMPGSWAA----GTVLITGGTGMAGSAVARHVVARHGVRNLVL 176 Query 1259 ASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAG 1318 SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++P + GVIH AG Sbjct 177 VSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAG 235 Query 1319 VLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYS 1378 LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS GQ NY+ Sbjct 236 ALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYA 295 Query 1379 AANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAV 1438 AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLAR+ R G+ +S AEA+ Sbjct 296 AANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEAL 355 Query 1439 ELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKS 1498 ELFD A+ +D P +D AL RA A A+P +FS LA P RRQ+DD+ A SKS Sbjct 356 ELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKS 413 Query 1499 ALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNR 1558 ALA RLHGL EQ +L+GLV L A VLG + E +DPD F DLGFDSLTAVE+RNR Sbjct 414 ALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNR 473 Query 1559 LKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 LK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 474 LKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 506 >gi|253798895|ref|YP_003031896.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|253320398|gb|ACT25001.1| hypothetical protein TBMG_01933 [Mycobacterium tuberculosis KZN 1435] gi|328458652|gb|AEB04075.1| polyketide synthase pks12 [Mycobacterium tuberculosis KZN 4207] gi|344219874|gb|AEN00505.1| polyketide synthase pks12 [Mycobacterium tuberculosis CTRI-2] Length=4152 Score = 1662 bits (4305), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2500 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2559 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2560 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2619 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2620 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2679 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2680 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2739 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2740 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2799 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2800 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2859 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2860 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2917 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2918 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2975 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2976 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3035 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3036 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3095 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3096 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3155 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3156 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3215 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3216 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3261 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3262 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3318 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3319 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3378 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3379 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3438 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3439 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3498 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3499 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3558 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3559 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3618 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3619 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3678 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3679 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3734 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3735 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3793 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3794 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3853 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3854 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3913 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3914 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3973 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3974 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4033 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4034 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4079 Score = 1358 bits (3516), Expect = 0.0, Method: Compositional matrix adjust. Identities = 836/1609 (52%), Positives = 1047/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 477 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 536 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 537 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 596 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 597 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 656 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 657 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 716 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 717 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 776 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 777 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 833 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 834 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 892 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 893 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 950 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 951 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1010 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1011 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1070 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1071 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1129 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1130 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1185 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1186 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1229 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1230 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1280 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1281 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1340 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1341 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1400 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1401 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1459 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1460 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1519 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1520 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1579 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1580 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1639 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1640 VLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1695 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1696 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1755 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1756 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1814 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1815 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1874 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1875 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1932 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1933 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1992 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1993 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2041 >gi|298525551|ref|ZP_07012960.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] gi|298495345|gb|EFI30639.1| polyketide synthase [Mycobacterium tuberculosis 94_M4241A] Length=4151 Score = 1662 bits (4305), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1358 bits (3516), Expect = 0.0, Method: Compositional matrix adjust. Identities = 836/1609 (52%), Positives = 1047/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|148823264|ref|YP_001288018.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] gi|148721791|gb|ABR06416.1| hypothetical protein TBFG_12085 [Mycobacterium tuberculosis F11] Length=4151 Score = 1662 bits (4305), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1364 bits (3531), Expect = 0.0, Method: Compositional matrix adjust. Identities = 839/1609 (53%), Positives = 1051/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|297731612|ref|ZP_06960730.1| hypothetical protein MtubKR_11001 [Mycobacterium tuberculosis KZN R506] Length=4152 Score = 1662 bits (4304), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2500 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2559 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2560 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2619 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2620 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2679 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2680 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2739 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2740 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2799 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2800 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2859 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2860 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2917 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2918 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2975 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2976 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3035 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3036 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3095 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3096 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3155 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3156 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3215 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3216 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3261 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3262 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3318 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3319 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3378 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3379 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3438 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3439 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3498 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3499 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3558 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3559 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3618 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3619 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3678 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3679 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3734 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3735 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3793 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3794 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3853 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3854 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3913 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3914 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3973 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3974 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4033 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4034 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4079 Score = 1364 bits (3531), Expect = 0.0, Method: Compositional matrix adjust. Identities = 839/1609 (53%), Positives = 1051/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 477 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 536 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 537 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 596 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 597 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 656 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 657 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 716 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 717 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 776 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 777 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 833 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 834 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 892 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 893 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 950 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 951 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1010 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1011 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1070 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1071 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1129 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1130 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1185 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1186 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1229 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1230 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1280 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1281 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1340 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1341 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1400 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1401 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1459 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1460 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1519 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1520 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1579 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF Sbjct 1580 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDG 1639 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1640 VLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1695 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1696 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1755 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1756 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1814 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1815 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1874 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1875 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1932 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1933 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1992 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1993 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2041 >gi|297634625|ref|ZP_06952405.1| hypothetical protein MtubK4_10901 [Mycobacterium tuberculosis KZN 4207] gi|313658946|ref|ZP_07815826.1| hypothetical protein MtubKV_11016 [Mycobacterium tuberculosis KZN V2475] Length=4152 Score = 1662 bits (4304), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2500 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2559 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2560 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2619 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2620 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2679 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2680 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2739 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2740 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2799 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2800 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2859 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2860 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2917 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2918 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2975 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2976 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3035 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3036 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3095 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3096 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3155 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3156 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3215 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3216 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3261 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3262 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3318 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3319 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3378 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3379 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3438 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3439 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3498 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3499 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3558 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3559 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3618 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3619 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3678 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3679 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3734 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3735 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3793 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3794 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3853 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3854 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3913 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3914 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3973 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3974 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4033 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4034 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4079 Score = 1364 bits (3530), Expect = 0.0, Method: Compositional matrix adjust. Identities = 839/1609 (53%), Positives = 1051/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 477 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 536 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 537 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 596 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 597 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 656 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 657 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 716 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 717 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 776 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 777 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 833 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 834 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 892 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 893 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 950 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 951 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1010 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1011 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1070 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1071 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1129 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1130 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1185 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1186 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1229 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1230 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1280 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1281 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1340 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1341 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1400 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1401 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1459 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1460 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1519 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1520 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1579 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF Sbjct 1580 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDG 1639 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1640 VLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1695 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1696 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1755 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1756 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1814 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1815 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1874 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1875 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1932 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1933 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1992 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1993 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2041 >gi|254232218|ref|ZP_04925545.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289574727|ref|ZP_06454954.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339632088|ref|YP_004723730.1| polyketide synthase [Mycobacterium africanum GM041182] gi|124601277|gb|EAY60287.1| hypothetical protein TBCG_02001 [Mycobacterium tuberculosis C] gi|289539158|gb|EFD43736.1| polyketide synthase pks12 [Mycobacterium tuberculosis K85] gi|339331444|emb|CCC27133.1| putative polyketide synthase pks12 [Mycobacterium africanum GM041182] Length=4151 Score = 1662 bits (4304), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1353 bits (3502), Expect = 0.0, Method: Compositional matrix adjust. Identities = 835/1609 (52%), Positives = 1046/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|15841536|ref|NP_336573.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] gi|13881781|gb|AAK46387.1| polyketide synthase [Mycobacterium tuberculosis CDC1551] Length=4151 Score = 1662 bits (4303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1353 bits (3501), Expect = 0.0, Method: Compositional matrix adjust. Identities = 835/1609 (52%), Positives = 1046/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|294996987|ref|ZP_06802678.1| polyketide synthase Pks12 [Mycobacterium tuberculosis 210] Length=4151 Score = 1661 bits (4302), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQV+ACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVLACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1358 bits (3515), Expect = 0.0, Method: Compositional matrix adjust. Identities = 836/1609 (52%), Positives = 1047/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|289447668|ref|ZP_06437412.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] gi|289420626|gb|EFD17827.1| polyketide synthase pks12 [Mycobacterium tuberculosis CPHL_A] Length=4151 Score = 1661 bits (4301), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1134/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWYLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1353 bits (3501), Expect = 0.0, Method: Compositional matrix adjust. Identities = 835/1609 (52%), Positives = 1046/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|148661862|ref|YP_001283385.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] gi|148506014|gb|ABQ73823.1| polyketide synthase Pks12 [Mycobacterium tuberculosis H37Ra] Length=4151 Score = 1660 bits (4299), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1606 (59%), Positives = 1134/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL E GP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1349 bits (3492), Expect = 0.0, Method: Compositional matrix adjust. Identities = 834/1609 (52%), Positives = 1045/1609 (65%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVW P GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWAPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|15609185|ref|NP_216564.1| polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] gi|2896785|emb|CAA17262.1| Probable polyketide synthase pks12 [Mycobacterium tuberculosis H37Rv] Length=4151 Score = 1657 bits (4292), Expect = 0.0, Method: Compositional matrix adjust. Identities = 931/1606 (58%), Positives = 1133/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++E LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL E GP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVRCAPAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRCAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1353 bits (3501), Expect = 0.0, Method: Compositional matrix adjust. Identities = 835/1609 (52%), Positives = 1046/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|340627059|ref|YP_004745511.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] gi|340005249|emb|CCC44403.1| putative polyketide synthase pks12 [Mycobacterium canettii CIPT 140010059] Length=4154 Score = 1657 bits (4291), Expect = 0.0, Method: Compositional matrix adjust. Identities = 933/1606 (59%), Positives = 1135/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2502 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2561 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2562 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2621 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2622 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2681 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2682 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2741 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2742 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2801 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2802 IISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2861 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2862 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2919 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS + Q WLADH V Sbjct 2920 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSV 2977 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2978 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3037 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3038 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3097 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3098 PAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3157 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3158 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3217 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3218 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3263 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3264 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3320 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3321 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3380 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3381 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3440 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3441 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3500 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3501 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3560 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3561 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3620 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3621 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3680 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3681 FDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3736 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ + Sbjct 3737 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-RLS 3795 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIHAAG LDDAV+TSLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3796 GVIHAAGALDDAVVTSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3855 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L++ D R +R G+ Sbjct 3856 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVA 3915 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3916 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3975 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3976 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4035 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4036 AVEMRNRLKSATGLALSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4081 Score = 1340 bits (3467), Expect = 0.0, Method: Compositional matrix adjust. Identities = 835/1612 (52%), Positives = 1045/1612 (65%), Gaps = 65/1612 (4%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATPAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVRPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIALCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRP 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L + F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSTASAFVAGVAVDWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVL---TGR 465 V+LPTYAF +RRFW + G ADA GLGLGA+EH LLGAVV+ P S +VL TGR Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADAFGLGLGASEHPLLGAVVDLPASGGMVLMVLTGR 949 Query 466 LSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQV 525 LS QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V V Sbjct 950 LSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAV 1009 Query 526 QVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDIS 585 QVVV A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++ Sbjct 1010 QVVVDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVAVDVA 1069 Query 586 DGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHA 645 DGY +LA GY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA Sbjct 1070 DGYERLATCGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHA 1128 Query 646 LGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTV 705 + +A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V Sbjct 1129 VVIAGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSV 1184 Query 706 RSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAG 765 S+V RP+T QL AAV+ +G EV+WS S V+ A GS P + Sbjct 1185 ASMVARPVTERQLLAAVSGSG---PDRLFEVIWSRASGVT--ALGSTPAYQI-------- 1231 Query 766 SDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLA 825 ES V GS Y +H AL +QSWL + LVV T G + L Sbjct 1232 -----------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALP 1279 Query 826 GEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVH 882 ED++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ Sbjct 1280 REDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVY 1339 Query 883 APRL--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVG 940 R+ S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ Sbjct 1340 TARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIA 1399 Query 941 VNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQ 999 NFRD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D Sbjct 1400 ANFRDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDV 1458 Query 1000 QLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQ 1059 +L+ +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHA TGGVGMAAVQLAR Sbjct 1459 RLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAATGGVGMAAVQLARH 1518 Query 1060 WGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFV 1119 G+EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFV Sbjct 1519 LGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFV 1578 Query 1120 DASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELF 1179 DASLRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL E G RM + + E+ LF Sbjct 1579 DASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLF 1638 Query 1180 DTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAV 1239 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG Sbjct 1639 GDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMA 1694 Query 1240 GGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGL 1299 G +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + Sbjct 1695 GSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKV 1754 Query 1300 FAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMF 1359 A + ++ P+ GVIH AG LDDAV+TSLTPDR+D VLR+KVDAAW+LH+ T DLD+S F Sbjct 1755 IADIPVQH-PLSGVIHTAGALDDAVVTSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAF 1813 Query 1360 ALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSR 1419 + SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT L + Sbjct 1814 VMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAA 1873 Query 1420 DLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLA 1479 DLAR+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA Sbjct 1874 DLARLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLA 1931 Query 1480 RRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPD 1539 P RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD Sbjct 1932 SAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPD 1991 Query 1540 TEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 F DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 KAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2043 >gi|121637934|ref|YP_978157.1| putative polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224990428|ref|YP_002645115.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|121493581|emb|CAL72055.1| Probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Pasteur 1173P2] gi|224773541|dbj|BAH26347.1| putative polyketide synthase [Mycobacterium bovis BCG str. Tokyo 172] gi|341601971|emb|CCC64645.1| probable polyketide synthase pks12 [Mycobacterium bovis BCG str. Moreau RDJ] Length=4151 Score = 1654 bits (4282), Expect = 0.0, Method: Compositional matrix adjust. Identities = 931/1606 (58%), Positives = 1134/1606 (71%), Gaps = 35/1606 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 2499 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 2558 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG L+ PVFA+AF+ V ELD Sbjct 2559 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVFAEAFNTVVGELD 2618 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLR+V+WG D +LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2619 RHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSA 2678 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGRLMQALPAGGAMVAV A+E+EV PLL V IAA+N P S Sbjct 2679 AHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIAAVNGPAS 2738 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 +VISGAQ A A+AD+ A GRRVHQLAVSHAFHSPLM+PM++EFA VAA + P +G Sbjct 2739 LVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIG 2798 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SNVTG+LAG DFGSA YW H+R+ VRFADS R Q G + F+E GP GL SIE+ Sbjct 2799 VISNVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEE 2858 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 SL +S L KDRPE A+ A Q F TG+ + W AV + + V+LPTYAFQR Sbjct 2859 SLPDVAVTTMSALRKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEA--QFVELPTYAFQR 2916 Query 421 RRFWETPGADG-PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRFW + DG ADAAGLGL A+EHALLGAV++ P S VVLTGRLS Q WLADH V Sbjct 2917 RRFWLS--GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPRVQGWLADHSV 2974 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 GV +FPGAGFVEL IRAGDEVGC +++EL LAAPLV+ V VQVVV DESG R Sbjct 2975 AGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRG 3034 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSRGD GW+L+AEG L +AE DL++WPP GA V+++DGY QLAERGY YG Sbjct 3035 VSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVADGYQQLAERGYGYG 3094 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 AF+GL A+WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + + Sbjct 3095 LAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERGQGS 3154 Query 660 RL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 L PF W+GVSLHA GA VRAR A G A+S+++ D GLPVL+V S++ RP+T +QL Sbjct 3155 VLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQL 3214 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCA-GSDGDASVVVWEL 777 RAAV+++G EV WSP P A V CA G+ D++ VV+E Sbjct 3215 RAAVSSSG---PDRLFEVTWSP-----------QPSAAVEPLPVCAWGTTEDSAAVVFES 3260 Query 778 ESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAV 837 G VV VYAAT + L+VLQSWL D A LVV+T G V L GED++DLA AAV Sbjct 3261 VPLAGD---VVAGVYAATSSVLDVLQSWLTRDGAGVLVVMTRGAVALPGEDVTDLAGAAV 3317 Query 838 WGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTVHAPRLSPAPAL-- 892 WG+ RSAQ E+PGRIVL+D+DA +D S LA V GEPQ+L R G V+ R+ + A+ Sbjct 3318 WGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRRGEVYTARVHGSRAVGG 3377 Query 893 LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGM 952 L +P ++ WRLA GT E+L ++ P+ APL GQVRVAV+A+ NFRDV+ ALG+ Sbjct 3378 LLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGL 3437 Query 953 YPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTRVPQGWSF 1011 YP +G E GVV+ET AVGD VMG F G G +A DQ+L+ +VP GWS Sbjct 3438 YPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSH 3497 Query 1012 AQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRG 1071 AA VVF TA Y L DLA ++G+ VLIHAGTGGVGMAAVQLAR G+EVF TAS+G Sbjct 3498 TAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKG 3557 Query 1072 KWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGR 1131 KWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDASLRL+ GG Sbjct 3558 KWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGV 3617 Query 1132 FLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTT 1191 FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF L LPVTT Sbjct 3618 FLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT 3677 Query 1192 WDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAY 1251 +DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G +ARH+V + Sbjct 3678 FDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSAVARHVVARH 3733 Query 1252 GVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVR 1311 GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A + ++ P+ Sbjct 3734 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIADIPVQH-PLS 3792 Query 1312 GVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS 1371 GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + SS+A VGS Sbjct 3793 GVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGS 3852 Query 1372 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAP 1431 GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT+ L++ D R +R G+ Sbjct 3853 SGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIVA 3912 Query 1432 MSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTG 1491 MS A+A++LFD A+ +D P + +D AAL + G LP +F L P RRQ+DD+ Sbjct 3913 MSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSL 3972 Query 1492 DATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLT 1551 A SKSAL QRL GL DEQ +L+ LV A VLG S E +DPD F +LGFDSLT Sbjct 3973 AAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT 4032 Query 1552 AVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTES 1597 AVE+RNRLK+ATGL+L PT+IFD+P A+A Y+ +++ GS P ++ Sbjct 4033 AVEMRNRLKSATGLSLSPTLIFDYPNSAALAGYMRRELLGSSPQDT 4078 Score = 1360 bits (3519), Expect = 0.0, Method: Compositional matrix adjust. Identities = 838/1609 (53%), Positives = 1051/1609 (66%), Gaps = 62/1609 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL QA RL A+V+ + GLD DVG SLA RSVFEHRAVVVG R++L+AGL Sbjct 476 VVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGL 535 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LA + G V G + GKTV VFPGQG+Q +GMG EL P FAQ DA A+ Sbjct 536 DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFA 595 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ GA A LD + QP LFAV V+ + + V PD V+GHS GE+A Sbjct 596 EFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIA 655 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+ L G MV++A D+ LL G+ V IA +N Sbjct 656 AAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVN 715 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P +VV+SG A + + + R ++ V +A HS +E + A + ++ R Sbjct 716 GPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRS 775 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 + S VTG + AG D A YW +VR+ V F + R+ G FIE+ P Sbjct 776 TRTVFFSTVTGNRLDTAGLD---ADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPA 832 Query 354 LTGSIEQSLA-----PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L +E++ A +EA+VV LG+ L L +A F GV V W G+G Sbjct 833 LITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAG- 891 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF +RRFW + G AD +GLGLGA+EH LLGAVV+ P S VVLTGRLS Sbjct 892 -YVELPTYAFDKRRFWLSAEGSG-ADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSP 949 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 QPWLADH V+ VVLFPG GFVEL IRAGDEVGC++++EL LAAPL++ V VQVV Sbjct 950 NVQPWLADHAVSDVVLFPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPATGSVAVQVV 1009 Query 529 VGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGY 588 V A +S R VS++SR D GWLL+AEG+L + E DLSVWPP GA +VD++DGY Sbjct 1010 VDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGY 1069 Query 589 AQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGL 648 +LA RGY YGPAF+GL A+W RG E+FAEV P EA V G+HPA+LDAVLHA+ + Sbjct 1070 ERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLP-EAAGGVGGFGVHPALLDAVLHAVVI 1128 Query 649 AVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSL 708 A + E LPF W+GVSLHA GA VRAR A AG A+SV++ D GLPVL+V S+ Sbjct 1129 AGDPD----ELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASM 1184 Query 709 VTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDG 768 V RP+T QL AAV+ +G EV+WSP A+ + P P Sbjct 1185 VARPVTERQLLAAVSGSG---PDRLFEVIWSP-------ASAATSPGPTPAYQI------ 1228 Query 769 DASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGED 828 ES V GS Y +H AL +QSWL + LVV T G + L ED Sbjct 1229 --------FESVAADQDPVAGS-YVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRED 1279 Query 829 ISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRGGTVHAPR 885 ++DLA AAVWG+ RSAQ E+PGRIVL+D+DAA D + +A GEPQ+++RGG V+ R Sbjct 1280 VADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTAR 1339 Query 886 L--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF 943 + S A + +P + WRL G GT E+L ++P P APL GQVRVA+ A+ NF Sbjct 1340 VRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANF 1399 Query 944 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLAVVDQQLV 1002 RD++ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G L D +L+ Sbjct 1400 RDIMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLL 1458 Query 1003 TRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGV 1062 +P WS+A+AAA+ VF TA+Y LA+++ G+ VLIHAGTGGVGMAAVQLAR G+ Sbjct 1459 LPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGL 1518 Query 1063 EVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDAS 1122 EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF A T GRG DVVLDSLAGEFVDAS Sbjct 1519 EVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS 1578 Query 1123 LRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTR 1182 LRL+ GG FLEMGKTDIRD IA YPGV+YRAFDL EAGP R+ ++LAE+ LF Sbjct 1579 LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDG 1638 Query 1183 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGV 1242 L LPVTT+DVR APAA R++SQARH GKVV+ MP + A GTV+ITG TG G Sbjct 1639 VLRLLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGS----WAAGTVLITGGTGMAGSA 1694 Query 1243 LARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQ 1302 +ARH+V +GVR+LVL SRRG A GAAEL A+L AGA+VQVVACD ADRAA+A + A Sbjct 1695 VARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIAD 1754 Query 1303 LSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALC 1362 + ++ P+ GVIH AG LDDAV+ SLTPDR+D VLR+KVDAAW+LH+ T DLD+S F + Sbjct 1755 IPVQH-PLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMF 1813 Query 1363 SSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLA 1422 SS+A VGS GQ NY+AAN+FLD LAAHR+A GL ISL WGLW+Q MT+ L + DLA Sbjct 1814 SSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLDAADLA 1873 Query 1423 RMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRP 1482 R+ R G+ +S AEA+ELFD A+ +D P +D AL RA A A+P +FS LA P Sbjct 1874 RLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTAL--RAHAVAVPPMFSDLASAP 1931 Query 1483 RRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEF 1542 RRQ+DD+ A SKSALA RLHGL EQ +L+GLV L A VLG + E +DPD F Sbjct 1932 TRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKAF 1991 Query 1543 GDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSG 1591 DLGFDSLTAVE+RNRLK+ATGL+L PT+IFD+PTP +A Y+ +++G Sbjct 1992 QDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG 2040 >gi|254820900|ref|ZP_05225901.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=2131 Score = 1641 bits (4249), Expect = 0.0, Method: Compositional matrix adjust. Identities = 949/1593 (60%), Positives = 1140/1593 (72%), Gaps = 45/1593 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLAS-RSVFEHRAVVVGASREQLIAG 59 V+SARS +AL QA RL+ H+ A P + +DVG SLA+ R+ FEHRAV++GA R L AG Sbjct 491 VVSARSTDALAGQAQRLLDHLGATPDVPAVDVGWSLATTRAAFEHRAVLIGADRAGLSAG 550 Query 60 LAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LAGLAAG P G G+ + GK V VFPGQG+Q +GMG LY P FAQAFD + Sbjct 551 LAGLAAGAPVPGAITGRTRAAGKRVFVFPGQGSQWLGMGAALYERFPAFAQAFDETETAV 610 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 D H RLPLR+V+WG+DA+LL STEFAQPALFA+E+A A+ GV PD V+GHSVGE+A Sbjct 611 DAHCRLPLREVMWGSDAELLQSTEFAQPALFALEIAMAALWESLGVTPDVVIGHSVGEIA 670 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AA AG L+L+DAA LV +RGRLM LP GG M+AV A+E +V PLL VGIAA+N P+ Sbjct 671 AACVAGALSLSDAARLVASRGRLMAQLPPGGVMMAVTATEADVAPLLNGDVGIAAVNGPQ 730 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 S+V+SG+++A +ADR AA G RV QLAVSHAFHSPLMEPM+ +FA V A V AREP++ Sbjct 731 SLVLSGSESAVKVVADRLAAGGARVRQLAVSHAFHSPLMEPMMGDFAAVVAGVSAREPRI 790 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 LVSN+TG+LAGPD+G+ YWVDHVR+PVRF D + ++LGA F+E GPG+ +T +++ Sbjct 791 ALVSNLTGQLAGPDYGTVAYWVDHVRKPVRFVDGVQLAESLGAGVFLEVGPGAAMTAAVD 850 Query 360 QSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQ 419 Q L AM V + K RPE+ S L AAGQ+F TG + WSA F G RR+ LPTYAF Sbjct 851 QCLTTDRAMSVVSMAKGRPEVDSLLSAAGQLFATGSDLDWSAAFTGLSARRIPLPTYAFV 910 Query 420 RRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRRFW + + G A+ A LGL EHALLGAVV+RPDS VVLTGRLS A QPWL DH V Sbjct 911 RRRFWLSSDSVGSANIASLGLTEAEHALLGAVVDRPDSGGVVLTGRLSTAAQPWLGDHAV 970 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 G VLFPGAGFVEL +RAGDEVGC++IEEL L+APL + G VQ+QVVV AAD +G RA Sbjct 971 AGTVLFPGAGFVELALRAGDEVGCSVIEELTLSAPLAVPVGGVVQLQVVVEAADGTGARA 1030 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSVYSR Q+ W+L+AEG+L A DLSVWPP GAE+VD++ Y LA+RGY YG Sbjct 1031 VSVYSRAAQTD-WILHAEGLLRDGATTPVTDLSVWPPVGAEAVDVAGAYDGLADRGYGYG 1089 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAFQGL A+WRRG+E FAEV P AGVA G+HP +LDA LHALG+A E+ ET Sbjct 1090 PAFQGLRAVWRRGAETFAEVELPQHAGVATGGFGIHPVLLDAALHALGVADER----IET 1145 Query 660 RLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLR 719 LPF W+GVSL+A GA RVR R A AG A+SVD+ DA+GLPVL+VR LVTR ++A+QLR Sbjct 1146 VLPFSWQGVSLYAAGASRVRVRLAPAGTGAVSVDLADASGLPVLSVRELVTRAVSADQLR 1205 Query 720 AAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELES 779 AA+ A G+ + L+VVWSPIS+ G V VWE Sbjct 1206 AALAARAGSGEL--LDVVWSPISLPGNGVG--------------------QGVTVWEPPP 1243 Query 780 AGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWG 839 + + +VY A H AL VLQSWL D A TLVV T G V L+ +D+SDLA AAVWG Sbjct 1244 G-----ASITAVYTAAHEALGVLQSWLSGDAAGTLVVQTRGAVTLSADDVSDLAGAAVWG 1298 Query 840 MARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPA--PALLALPA 897 + RSAQAE+PGRIVL+DTD ++D + + G GEPQL+VR G H+ RL PA ALL+LP Sbjct 1299 LVRSAQAEHPGRIVLVDTDGSLDVATVIGCGEPQLVVRDGIAHSARLKPAGQRALLSLPE 1358 Query 898 AESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQA 957 S WRLAAG GTLEDL +Q P A L+AGQVRVAVAA GVNFRDV+ ALGMYPG A Sbjct 1359 PPSVWRLAAGDAGTLEDLAVQEYPP--AELEAGQVRVAVAAAGVNFRDVLVALGMYPGAA 1416 Query 958 PPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAV 1017 LGAEGAG+V E G VTD+AVGDAVMG G AG A VD++LVTRVP+GWS AQAA V Sbjct 1417 -QLGAEGAGIVTEVGSGVTDVAVGDAVMGIFGLAGSEATVDRRLVTRVPRGWSMAQAAGV 1475 Query 1018 PVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLR 1077 PVVFLTA+YGL+ LA ++AG+ VL+HA TGGVGMAAVQLAR WG EVF TASRGKWDTLR Sbjct 1476 PVVFLTAYYGLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASRGKWDTLR 1535 Query 1078 AMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGK 1137 AMGFDD HI DSRT EFE KF A G VVL+SLAGEF DASLRLL RGGRF+EMGK Sbjct 1536 AMGFDDAHIADSRTLEFEHKFRAAVGAGGFGVVLNSLAGEFNDASLRLLGRGGRFIEMGK 1595 Query 1138 TDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCA 1197 TD+RD +A +PGV YRAFDL EAGP R+ EMLAE+ LF L LPV +D R A Sbjct 1596 TDLRDPDAVAHAHPGVGYRAFDLMEAGPDRIAEMLAELMTLFAGGALAPLPVKAFDARSA 1655 Query 1198 PAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLV 1257 A+RF+SQARHIGKVVLTMP A LA GT +ITG TG G +ARHLV + V H++ Sbjct 1656 ADAYRFVSQARHIGKVVLTMPDGPAG-LAGGTALITGGTGMAGSAVARHLVERHRVPHVM 1714 Query 1258 LASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAA 1317 L SR G++A G AELA +L + GA V VVACDV DR AVA L A++ Y P+R V HAA Sbjct 1715 LVSRGGEQAAGIAELAGELRDLGASVSVVACDVGDRDAVAALLARVPSHY-PLRSVFHAA 1773 Query 1318 GVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNY 1377 GV+DDA++ SLTP RID VLRAKVD AW+LH+ T +L L+ F SS+A VG+PGQGNY Sbjct 1774 GVIDDAMVASLTPARIDAVLRAKVDGAWHLHELTKELGLAAFVAFSSMAGIVGAPGQGNY 1833 Query 1378 SAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEA 1437 +AAN+FLD LAAHR A GL G+S+AWG+WE+P MT HL D ARMSR+GL+ +S +A Sbjct 1834 AAANSFLDALAAHRHARGLPGLSVAWGMWEEPSAMTHHLGEADRARMSRAGLSALSTRQA 1893 Query 1438 VELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSK 1497 ++L DAAL D P+ V T LDR AL + LP L S LA RP RR ++ T S Sbjct 1894 LDLLDAALLGDRPMVVGTRLDRGAL--AHHSATLPPLLSQLATRPARRVLEHTD--MVSL 1949 Query 1498 SALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRN 1557 + L RL GL+ +++ LV LVC AA VLG +A DV+ D FGDLGFDSLTAVELRN Sbjct 1950 TGLRARLDGLSPEQRQAELVELVCGNAATVLGHTTA-DVNADDAFGDLGFDSLTAVELRN 2008 Query 1558 RLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMS 1590 RLK ATGLTL PT+IFDHPTP A+AE++ +++ Sbjct 2009 RLKIATGLTLSPTLIFDHPTPAALAEHLGTELA 2041 >gi|240170497|ref|ZP_04749156.1| polyketide synthase, Pks12 [Mycobacterium kansasii ATCC 12478] Length=1565 Score = 1607 bits (4161), Expect = 0.0, Method: Compositional matrix adjust. Identities = 875/1529 (58%), Positives = 1067/1529 (70%), Gaps = 39/1529 (2%) Query 95 IGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEV 154 +GMG L+ P FA+AF+ V ELDRHL PLR+VIWG D +LL++TEFAQPALFAVEV Sbjct 2 LGMGMGLHAGYPAFAEAFNTVVAELDRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEV 61 Query 155 ASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVA 214 A + +L WG+ PDFVMGHSVGE++AAH AGVL+L +AA+LV ARGR MQALP GGAMVA Sbjct 62 ALYRLLESWGIRPDFVMGHSVGEISAAHVAGVLSLENAAVLVAARGRFMQALPPGGAMVA 121 Query 215 VAASEDEVEPLLGEGVGIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFH 274 VAA+E EV PLL V IAA+N P SVVISGA++A A+ADR A GRRVH+LAVSHAFH Sbjct 122 VAATEAEVGPLLSAEVSIAAVNGPASVVISGAESAVLAVADRLRADGRRVHRLAVSHAFH 181 Query 275 SPLMEPMLEEFARVAARVQAREPQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSA 334 SPLM+PM++EFA VA+ + +P + ++SNVTG+LA D+G+ YW HVR VRFADS Sbjct 182 SPLMDPMIDEFATVASGLAIGQPAIPIISNVTGQLAAGDYGTTAYWKRHVREAVRFADSV 241 Query 335 RHLQTLGATHFIEAGPGSGLTGSIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTG 394 R Q+ GAT F E GPGSGLT SIE+SL + +S L KDRPE + + A Q F G Sbjct 242 RFAQSAGATRFFEVGPGSGLTASIEESLPDTGILTISALRKDRPEPVTLVNAVAQAFVAG 301 Query 395 VPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADG-PADAAGLGLGATEHALLGAVVE 453 V V W V + V+LPTYAFQRRRFW + DG ADA LGL A+EHALLGAVVE Sbjct 302 VSVDWRTVVGQA--NFVELPTYAFQRRRFWLS--GDGVAADATDLGLEASEHALLGAVVE 357 Query 454 RPDSDEVVLTGRLSLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAA 513 P S VVLTGRLSL Q WLADH V GVV+FPGAGFVEL IRAGDEVGC ++EEL LAA Sbjct 358 LPTSGGVVLTGRLSLRAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGCGVVEELTLAA 417 Query 514 PLVMHPGVGVQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSV 573 PLV+ G V V+V+VG ADESG RAVSVYSR D GW+L+AEG L + DL+ Sbjct 418 PLVLPGGTSVAVEVIVGGADESGARAVSVYSRADAGAGWVLHAEGTLTNGSLAPTTDLAT 477 Query 574 WPPEGAESVDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMG 633 WPP GA V+I+DGY +LAERGY YGPAF+GL A+WRRG E+FAEV P +AGV+V G Sbjct 478 WPPVGAVPVEIADGYERLAERGYGYGPAFRGLNAMWRRGDEVFAEVALPADAGVSVAGFG 537 Query 634 MHPAVLDAVLHALGLAVEKTQ----ASTETRLPFCWRGVSLHAGGAGRVRARFASAGADA 689 +HP +LDA LHA+ LA + +PF W+GVSLHAGGA VRAR A G Sbjct 538 VHPVMLDAALHAVILASDGADDFGVDEGSVLVPFSWQGVSLHAGGASAVRARIAPVGPSR 597 Query 690 ISVDVCDATGLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGAN 749 +S+++ D GLPVL+V S++ RP+T +QLRAAV+ +G +V W+ A Sbjct 598 VSIELADGLGLPVLSVASMLARPVTDQQLRAAVSGSG---PDRLFQVDWT--------AQ 646 Query 750 GSAPPAPVSWADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGAD 809 SA PV + +D D+S VV+E G A + VY AT++ L+VLQSWL D Sbjct 647 PSAALEPVPVRAWGTTADSDSSTVVFESVPVPGDA---LAGVYTATNSVLDVLQSWLARD 703 Query 810 RAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGV 869 A LVV T G V L GED++DLA AAVWG+ RSAQ E+PGRIVL+DTDAA+D S LA V Sbjct 704 GAGVLVVTTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDTDAALDESALAAV 763 Query 870 ---GEPQLLVRGGTVHAPRL--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQ 924 GEPQ+L RGG V+ R+ S A L +P ++ WRL GT E+L ++P P+ Sbjct 764 LAAGEPQVLWRGGQVYIARVHGSRAVGALLVPPGDAPWRLGMSAAGTFENLRLEPIPDAD 823 Query 925 APLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAV 984 APLQ G VRV ++A+ NFRDV+ ALG+YP +G E +GVVLETGP+ AVGD V Sbjct 824 APLQPGHVRVRLSAIAANFRDVMIALGLYPDPEAVMGVEASGVVLETGPDDGGFAVGDRV 883 Query 985 MG-FLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIH 1043 MG F G G +A D +L+ +VP GWS AA VVF TA+Y L LA ++ G+ +L+H Sbjct 884 MGLFPEGTGTIAATDHRLLVKVPAGWSHTAAATTSVVFATAYYALRHLASVQQGQRILVH 943 Query 1044 AGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTE 1103 A TGGVGMAAVQLAR WG+EVF TAS+GKWDTLRAMGFDDDHI DSR+ EFE+KF + T Sbjct 944 AATGGVGMAAVQLARHWGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRSATG 1003 Query 1104 GRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEA 1163 GRGVDVVLDSLAG+FVDASLRL+ GG FLEMGKTDIR+ + IA YPGV+YRAFDL EA Sbjct 1004 GRGVDVVLDSLAGDFVDASLRLVTPGGAFLEMGKTDIREPEVIAQQYPGVRYRAFDLFEA 1063 Query 1164 GPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALAD 1223 GP R+ ++LAE+ LFD L LPVTT+DVR APAA R++SQARH+GKVV++MP D Sbjct 1064 GPDRIAQILAELAALFDDEVLRPLPVTTFDVRRAPAALRYLSQARHVGKVVMSMP----D 1119 Query 1224 RLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKV 1283 A GTV+ITG TG G LARH+V +GVR LVL SRRG A GA EL A+L AGA+V Sbjct 1120 AWAAGTVLITGGTGMAGSALARHVVTRHGVRQLVLVSRRGPDAPGAEELVAELDAAGAQV 1179 Query 1284 QVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDA 1343 VVACD ADRAA+A + A + + P+ VIH AG LDDAV+TSLTP+R++TVLRAKVDA Sbjct 1180 HVVACDAADRAALAKVIADIPVQQ-PLSAVIHTAGALDDAVVTSLTPERMETVLRAKVDA 1238 Query 1344 AWNLHQATSDLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAW 1403 AWNLH+ T DLD+S F + SS+A VGS GQ NY+AAN+FLDGLA HR+A GL ISL W Sbjct 1239 AWNLHELTCDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDGLAVHRRARGLPAISLGW 1298 Query 1404 GLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALD 1463 GLW Q MT L+S D R +R G+ MS EA+ L D A+ +D P + +D AAL Sbjct 1299 GLWNQASAMTGGLASVDFKRFARDGVVAMSSEEALGLLDTAMIVDEPFMLPAHIDFAALR 1358 Query 1464 ARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQ 1523 + G LP +F L P RRQ+DD+ A SKSAL QRL GL DEQ +L+ LV Sbjct 1359 VKFDNGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLDGLPDDEQHAILLDLVRSN 1418 Query 1524 AAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAE 1583 A VLG S E +DPD F +LGFDSLTAVE+RNRLK+ATGL L PT+IFD+P A+A Sbjct 1419 IATVLGNTSPEAIDPDRAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAALAG 1478 Query 1584 YVAQQMSGSRPTESGDPTSQVVEPAAAEV 1612 Y+ +++ G+ P P + V P AE+ Sbjct 1479 YMHRELLGASP-----PDAPVAAPGEAEL 1502 >gi|41407894|ref|NP_960730.1| Pks12 [Mycobacterium avium subsp. paratuberculosis K-10] gi|41396248|gb|AAS04113.1| Pks12 [Mycobacterium avium subsp. paratuberculosis K-10] Length=4170 Score = 1601 bits (4146), Expect = 0.0, Method: Compositional matrix adjust. Identities = 914/1618 (57%), Positives = 1125/1618 (70%), Gaps = 41/1618 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 ++SA+SA AL AQA RL +V+A+ LD DVG +LA R+ FEHRAVVVG R++L+AGL Sbjct 2507 MVSAKSAAALRAQAARLAEYVRAHGELDIADVGWTLAGRATFEHRAVVVGGDRDRLLAGL 2566 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 L+ +P A + G GKTV VFPGQG+Q +GMGR+L+ PVFA+AFDAV ELD Sbjct 2567 DELSTDDPAASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVFAEAFDAVVAELD 2626 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLRDVIWG D ++L+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2627 RHLLRPLRDVIWGDDENVLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELSA 2686 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGR MQALP GGAM+AV A+E +V PLLG VGIAA+N P + Sbjct 2687 AHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLGPDVGIAAVNGPAA 2746 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISG AA AIA+R A+G RVH+L+VSHAFHSPLMEPM++EF VAA + + +P + Sbjct 2747 VVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLASDKPVIP 2806 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SN+TG+ A DFGS +YW HVR VRFADS R Q+ GAT F+E GP SGLT +IE+ Sbjct 2807 IISNLTGQPAADDFGSPEYWKRHVRDAVRFADSVRFAQSAGATRFLEVGPSSGLTAAIEE 2866 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 +LA A + VS L KDRPE + + A Q + G+ V W G V LPTYAF R Sbjct 2867 TLADAPVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALG--TGHLVDLPTYAFDR 2924 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFW + G +DAAGLGL A +HALLGAVVE P S V+LTGRLS A Q WLADH V Sbjct 2925 RRFWLS-GDGAASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSSASQGWLADHAVG 2983 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVEL IRAGDEVGC +I+EL LAAPLV+ G V +QVVV D+SG RAV Sbjct 2984 GVVLFPGAGFVELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVVVDGPDDSGARAV 3043 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SV+SR D GWLL+AEG+L +A+ DLS WPP GA VD+ DGY QLAERGY YGP Sbjct 3044 SVFSRADAGAGWLLHAEGVLRAGSAQPATDLSAWPPVGAVPVDLGDGYEQLAERGYRYGP 3103 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AF+GL ++WRRG E+FAEV P +AGV+ G+HP +LDA LHA+ LA + + + Sbjct 3104 AFRGLTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHAVMLASDGDELPAGSM 3163 Query 661 L-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLR 719 L PF W+ VSLHA GA VRAR A+S+++ D GLPVL+V S+V RP+T +QL Sbjct 3164 LVPFSWQRVSLHAAGAAAVRARIVPVSPSAVSIELADGLGLPVLSVASMVARPVTDQQLL 3223 Query 720 AAVTAAGGASDQGP---LEVVWSPISVVSGGANGSAPPAPVSWADFCA------GSDGDA 770 AAV S+ GP E++WS A S PVS ++ A +D D+ Sbjct 3224 AAV------SNSGPDRLFELIWS--------AQPSTAVQPVSLLNWGATELDATDTDSDS 3269 Query 771 SVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDIS 830 ESA A VV VYAAT L VLQ+WL D A TLVV T G + L ED++ Sbjct 3270 GRFAVLFESA-PVAGDVVTEVYAATRAVLPVLQTWLARDGAGTLVVSTRGAMTLPREDVT 3328 Query 831 DLAAAAVWGMARSAQAENPGRIVLIDTDA---AVDASVLAGVGEPQLLVRGGTVHAPRL- 886 DLA AAVWG+ RSAQ E+PGRIVL+DTDA A + + VGEPQ L+R GTV+ R+ Sbjct 3329 DLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDADAVAAVLAVGEPQTLLRNGTVYTARVL 3388 Query 887 -SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRD 945 S A L +P + WRL GT+E+L ++P P+ APL GQVRVA +A+ NFRD Sbjct 3389 GSRAVGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSALAANFRD 3448 Query 946 VVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTR 1004 V+ ALG+YP +G E +GVV+ET + +AVGD VMG F G G +A+ DQ+L+ + Sbjct 3449 VMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTGTVAITDQRLLVK 3508 Query 1005 VPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEV 1064 VP GWS AA VVF TA+Y L DLA+ + G+ VL+HA GGVGMAAVQLAR +G+EV Sbjct 3509 VPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAVQLARHFGLEV 3568 Query 1065 FVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLR 1124 F TASRGKWDTLR MGFDDDH+GDSR +FE+KF AVT G G+D+VLDSL+G+ VDASLR Sbjct 3569 FATASRGKWDTLRDMGFDDDHLGDSRGLDFEDKFRAVTGGAGMDIVLDSLSGDSVDASLR 3628 Query 1125 LLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTREL 1184 L+ GG FLEMGKTDIRD + +AA +PGV+YRAFDL EAGP R+ +L E+ +F L Sbjct 3629 LVAPGGIFLEMGKTDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAMFGEDVL 3688 Query 1185 HRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLA 1244 LPVT +DVR APAA R++SQARH+GKVV+TMP D GTV+ITGATG G +A Sbjct 3689 RPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITGATGMAGSAVA 3744 Query 1245 RHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLS 1304 RH+V +G R+LVL SRRG A GAAEL A+LT AGA+ +VVACD ADR A+A + A + Sbjct 3745 RHVVTRHGARNLVLVSRRGLDAPGAAELVAELTAAGARAEVVACDAADREALAKVIADIP 3804 Query 1305 REYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSS 1364 ++ P+ GVIHAAGVL+DAV+TSLTP RIDTVLRAKVDAAWNLH+ T DLD+ F + SS Sbjct 3805 MQH-PLTGVIHAAGVLEDAVVTSLTPQRIDTVLRAKVDAAWNLHELTRDLDVGAFVMFSS 3863 Query 1365 IAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARM 1424 IA G+ GQGNY+A N+FLDGLAAHR+A GL ISL WGLW+Q MT L + DLAR Sbjct 3864 IAGLAGASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARF 3923 Query 1425 SRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRR 1484 R G+ MS EA+EL D AL +D P + +D AAL A+ G LP +F L P R Sbjct 3924 GRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRAKFDGGTLPPMFVDLINAPTR 3983 Query 1485 RQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGD 1544 RQ+DD+ A SKSAL QRL GL DEQ +L+ LV A VLG S E + PD F + Sbjct 3984 RQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIHPDRAFQE 4043 Query 1545 LGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS--RPTESGDP 1600 LGFDSLTAVE+RNRLK ATGL L PT+IFD+P A+A Y+ +++ G+ +PT + P Sbjct 4044 LGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAP 4101 Score = 1355 bits (3506), Expect = 0.0, Method: Compositional matrix adjust. Identities = 833/1620 (52%), Positives = 1055/1620 (66%), Gaps = 68/1620 (4%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 ++SA+SA AL AQA RL +V+A+ LD DVG +LA R+ FEHRAVVVG R++L+AGL Sbjct 473 MVSAKSAAALRAQAARLAEYVRAHGELDIADVGWTLAGRATFEHRAVVVGGDRDRLLAGL 532 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 L+ +P A + G GKTV VFPGQG+Q +GM EL PVFAQ A + Sbjct 533 DELSTDDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFAQHIQACEEAFA 592 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L D + GA A +D + QPALFAV V+ + + GV PD V+GHS GE+A Sbjct 593 EFVDWSLIDALRGAPGAAGMDRVDVVQPALFAVMVSLAELWKSVGVSPDAVIGHSQGEIA 652 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+++L G M+++A S + LL G V IAA+N Sbjct 653 AAYVAGALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVN 712 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 SVV+SG AA + +A A R ++ V +A HS +E + E+ A+ ++ R Sbjct 713 GRSSVVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPRS 772 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 ++ S VTG + AG D A YW ++R+ V+F + R G FIE+ P Sbjct 773 SRIAFFSTVTGNRLDTAGLD---ADYWYRNIRQTVQFDQAVRSAAEHGYRTFIESSPHPA 829 Query 354 LTGSIEQSLAPA-----EAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L IE ++ + EA+V+ LG+D L L +A F GV V W V G+G Sbjct 830 LVAGIEDTVNDSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWRGVLDGAG- 888 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF RRRFW + G ADA+GLGLG +EH LL AVVE P S VVLTGRLS Sbjct 889 -FVELPTYAFDRRRFWLS-GEGAAADASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSP 946 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVM---HPGVG-VQ 524 + Q WL DH V+G V+FPGAGFVEL IRAGDEVGC+ +EEL L APL++ G+G V Sbjct 947 SLQGWLTDHAVSGTVVFPGAGFVELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVA 1006 Query 525 VQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDI 584 VQVVVG ADESG R VS++SR D W+ +A+G L + E DLS WPP GA VDI Sbjct 1007 VQVVVGEADESGRRDVSIFSRPDSDSPWVCHAQGTLSTGSIEPGADLSAWPPAGATKVDI 1066 Query 585 SDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLH 644 +DGY +LA RGY YGPAFQGL A W RG E+FAEV P AG V G+HPA+LDA +H Sbjct 1067 ADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAG-GVTGFGVHPALLDAAMH 1125 Query 645 ALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFA------SAGADAISVDVCDAT 698 AL + + E LPF W+GVSLHA GA VRAR A +A + A+S+++ D Sbjct 1126 ALIVGHQIAGDRDEVVLPFAWQGVSLHAAGASAVRARLAPAQAPGTAASRAVSLELADGL 1185 Query 699 GLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVS 758 GLPVL+VR++V R ++ QLRAAV+AAG EV W+P++V + A+G PP Sbjct 1186 GLPVLSVRAMVARSVSERQLRAAVSAAG---PDRLFEVAWAPVTVPA--AHGE-PPVHQV 1239 Query 759 WADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLT 818 + A +GD VG Y TH AL +QSWL + LVV+T Sbjct 1240 FESLAA--EGDP-----------------VGESYRRTHEALAAVQSWLTEHDSGVLVVVT 1280 Query 819 HGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAG---VGEPQLL 875 G + LAGED++DL+ AAVWG+ RSAQ E+PGRIVLID+DAA+D S L GEPQ+L Sbjct 1281 RGAMALAGEDVTDLSGAAVWGLVRSAQTEHPGRIVLIDSDAALDDSALTAALATGEPQVL 1340 Query 876 VRGGTVHAPRLSPAPAL--LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVR 933 +R GTV+ R+ + A+ + P + WRL GT E+L ++P P A LQ GQVR Sbjct 1341 LRDGTVYTARVHGSRAVDGIMTPPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVR 1400 Query 934 VAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAG 992 VA+ A+ NFRDV+ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G Sbjct 1401 VALRAIATNFRDVMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSG 1459 Query 993 PLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMA 1052 L D +L+ P WS+ +AA + VF TA+ LA++K G+ VL+HA GGVGMA Sbjct 1460 TLVPGDVRLLQHKPAHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMA 1519 Query 1053 AVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLD 1112 AVQLAR G+EVF TASRGKWDTLRAMGFDDDHIGDSRT +FE+KF + T G G+DVVLD Sbjct 1520 AVQLARHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLDFEDKFRSATGGAGMDVVLD 1579 Query 1113 SLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEML 1172 SLAGEFV+ASLRL+ GG FLEMGKTDIRD + YPGV+YRAFDL E G RM + + Sbjct 1580 SLAGEFVNASLRLVAPGGVFLEMGKTDIRDPGVVVREYPGVRYRAFDLFEPGRPRMHQWM 1639 Query 1173 AEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVI 1232 E+ LFD L+ LPVTT+D+R AA R++SQARHIGKVV+T+P A L+ GTV+I Sbjct 1640 VELAGLFDAGVLNPLPVTTFDIRRGRAALRYLSQARHIGKVVMTVPGA----LSAGTVLI 1695 Query 1233 TGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVAD 1292 TG TG G LARHLV +GVR L L SR G A GAAEL A+L AGA+VQV+ACD AD Sbjct 1696 TGGTGMAGSTLARHLVTGHGVRDLALLSRTGPDAPGAAELVAELEAAGARVQVIACDAAD 1755 Query 1293 RAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATS 1352 RAA+AG+ A +S + P+ GVIHAAGVLDDA+ITSLTP+RID VLRAKVDAAWNLH+ T Sbjct 1756 RAALAGVIAGISAQR-PLSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTR 1814 Query 1353 DLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGM 1412 D++LS F + SS+A VGS GQGNY+AAN+FLD LAAHR+A GL ISLAWGLW+Q M Sbjct 1815 DMNLSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAM 1874 Query 1413 TAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALP 1472 T L + DLAR+ R G+ +S EA+ELFD AL +D P +D AL RA A A+P Sbjct 1875 TGGLDAADLARLGRDGILALSSDEAMELFDTALIVDEPFLAPARIDLGAL--RAHAVAVP 1932 Query 1473 ALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPS 1532 +F+ L P RR++DD+ A SKSALA RL GL EQ +L+ LV A VLG P+ Sbjct 1933 PMFAELVNAPTRRRVDDSLAAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPT 1992 Query 1533 AEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS 1592 AE +DPD F +LGFDSLTAVE+RNRLKTATGL L PT+IFD+PTP A+A Y+ +++G+ Sbjct 1993 AEAIDPDKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELAGA 2052 >gi|183983097|ref|YP_001851388.1| polyketide synthase PKS [Mycobacterium marinum M] gi|183176423|gb|ACC41533.1| polyketide synthase PKS [Mycobacterium marinum M] Length=2666 Score = 1600 bits (4144), Expect = 0.0, Method: Compositional matrix adjust. Identities = 919/1633 (57%), Positives = 1117/1633 (69%), Gaps = 38/1633 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S +AL AQA RL+ V + GLDP+DVG SLA R VFEHRAVVVG RE L+AGL Sbjct 497 VLSAQSRQALVAQASRLLGRVGGDDGLDPVDVGLSLAQRCVFEHRAVVVGRDREALLAGL 556 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 GLA GEPGAGV VGQ +VGKTV+VFPGQGAQ GMGR+L+ E PVFA+ + L Sbjct 557 TGLARGEPGAGVVVGQAAAVGKTVLVFPGQGAQWTGMGRQLFDESPVFAERMRRCDEALA 616 Query 121 RHLRLPLRDVIWG-ADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ G A A LD + QP +A+ V+ + R GV PD V+GHS GE+A Sbjct 617 EFVSWSLLDVVTGVAGAPGLDRVDVVQPLSWAIMVSLAELWRSVGVTPDAVIGHSQGEIA 676 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA AG L+L D A +V R RL+ L GAM ++A E LL G+ + +AAIN Sbjct 677 AACVAGALSLRDGAAVVALRSRLLVDLAGAGAMASLACGVARAEQLLAGFGDRLDLAAIN 736 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 +VVISG A + D QG R ++ V +A HS ++ + A ++ R Sbjct 737 GVSAVVISGRVDAVLELMDLAETQGVRARRIEVDYASHSAQVDAIAGPLMEALAGIEPRP 796 Query 297 PQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTG 356 S VTG L YW +R+ V+FA++ R G F+EA L Sbjct 797 SSTSFFSTVTGGLMDTAELDGGYWFRSIRQTVQFAEAVRAAGAQGYGVFVEASAHPLLLN 856 Query 357 SIEQSLAP------AEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRR 410 +IE++LA +VV LG+D L +AGQ GV + W AV+AG G R Sbjct 857 AIEETLAEETGDAAKNVVVVPTLGRDDGGLGRFWMSAGQAHVAGVGMDWRAVYAGWGARL 916 Query 411 VQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLAD 470 V+LPTYAFQR+RFW P G D AGLGLG H LL A VE PDS EV+LTGRLSL+ Sbjct 917 VELPTYAFQRQRFWLPPAPTGSVDPAGLGLGEAGHGLLCAAVEHPDSREVILTGRLSLSA 976 Query 471 QPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVG 530 QPWLADH V GV+LFPG GF+ELVIRAGD VGC L+ EL + APLV+ V VQVQVVV Sbjct 977 QPWLADHAVLGVMLFPGTGFLELVIRAGDVVGCTLVRELTMVAPLVLSHDVPVQVQVVVA 1036 Query 531 AADESGHRAVSVYSRGDQ-SQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYA 589 G R+V+VYS D+ GWLLNA+G+L V + P ++S WPP GA V+ISD Y Sbjct 1037 PDGGDGSRSVTVYSHTDRPDSGWLLNAQGVLDVDVVQPPAEVSEWPPAGAVRVEISDAYE 1096 Query 590 QLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHA-LGL 648 QLA RG+ YG AF+G A+WRR ELFAEV P + R G+HPA+LDA LHA L Sbjct 1097 QLAARGFEYGQAFRGCTALWRRDQELFAEVALPEQVSAQAGRFGIHPALLDAALHAGLYG 1156 Query 649 AVE---KTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTV 705 A++ + E LP+ W+ VSL+AGGA R+R R + + +S+++ D+ G PVL+ Sbjct 1157 ALDFGGSRAGNAEAVLPYSWQRVSLYAGGAERLRVRITPSASGTVSIELADSAGGPVLSA 1216 Query 706 RSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAG 765 SL RP+ +LRAA++AA +DQG LE+ WSPI+V S +G P + WAD+ A Sbjct 1217 GSLAVRPVGTAELRAALSAAARETDQGLLELAWSPITVES--TSGGHRPVVLEWADYVAA 1274 Query 766 SD----GDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGG 821 D G A VV+W E AGG+ V+ Y ATH ALEVLQ WL DR+ATLV+ THG Sbjct 1275 DDDHAAGQADVVLWRCEPAGGR---VLDQAYRATHAALEVLQHWLARDRSATLVIATHGA 1331 Query 822 VGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAV-DASVLAGVGEPQLLVRGGT 880 VG A DI+DLA AAVWG+ RSAQ E+ GRIVLIDTD AV D + L EPQL+VR G Sbjct 1332 VGSAEHDITDLAGAAVWGLVRSAQTEHSGRIVLIDTDTAVVDLAGLLATKEPQLMVRAGR 1391 Query 881 VHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVG 940 VHA RL+ L LP + WRLAAGG GTL +V++P P+ QAPL GQVRVAVAA G Sbjct 1392 VHAARLAAVEETLVLPTHQQ-WRLAAGGEGTLAGVVMEPNPQAQAPLGPGQVRVAVAAAG 1450 Query 941 VNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQ 1000 VNFRDV+ LGMYPGQAPPLG EGAGVV+E G V L+VGD VMG +G AGP AVVDQ+ Sbjct 1451 VNFRDVLVVLGMYPGQAPPLGGEGAGVVVEVGHHVRRLSVGDQVMGLVGVAGPEAVVDQR 1510 Query 1001 LVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQW 1060 L+ ++P GWS AQAA VPV FLTAWYGL+DLA +++GESVL+HA TGGVGMAAVQLAR W Sbjct 1511 LLVKLPSGWSLAQAAGVPVAFLTAWYGLSDLAGVRSGESVLVHAATGGVGMAAVQLARHW 1570 Query 1061 GVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVD 1120 G+EVFVTASRGKWD LR MGFDDDHIGDSRT +F +KFLAVT+GRGVDVVL+SLAGEF+D Sbjct 1571 GLEVFVTASRGKWDILRRMGFDDDHIGDSRTVDFADKFLAVTDGRGVDVVLNSLAGEFID 1630 Query 1121 ASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFD 1180 ASLRLL RGGRF+EMGKTDIRD IA N+P V YRAFDL E+GPAR+Q ML + ELF Sbjct 1631 ASLRLLARGGRFIEMGKTDIRDPHTIAQNHPRVTYRAFDLLESGPARIQAMLGALLELFQ 1690 Query 1181 TRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVG 1240 R LH LP+ TWDVRC PAA+RF+SQARHIGKV+LTMP+ L D LA GTV+ITG TG V Sbjct 1691 ARALHPLPIKTWDVRCTPAAYRFVSQARHIGKVILTMPTLLPDALAAGTVLITGGTGMVA 1750 Query 1241 GVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLF 1300 LARHLV ++GVRHLVL SRRGD A GA++L +LT AGA V+VVACDVAD AAV+ L Sbjct 1751 AALARHLVSSHGVRHLVLVSRRGDAAAGASKLVDELTAAGATVRVVACDVADPAAVSRLM 1810 Query 1301 AQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFA 1360 QL + PP+ VIHAAG LDDA+ITSLTP R+D VLRAKVD AWNLH+AT DL LS F Sbjct 1811 NQLPEQCPPLSAVIHAAGTLDDALITSLTPQRVDAVLRAKVDGAWNLHEATRDLGLSAFV 1870 Query 1361 LCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRD 1420 LCSSIAAT+G+PGQ NY+A NAFLD LAAHR A GLAGISLAWGLWEQ MTAHL RD Sbjct 1871 LCSSIAATLGAPGQANYAAGNAFLDALAAHRHATGLAGISLAWGLWEQSSTMTAHLRGRD 1930 Query 1421 LARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLAR 1480 + RM+R G+ +S +A+ELFDAAL +DHP V + LD AAL + LP LF+ L R Sbjct 1931 VDRMTRIGMRAISAEQAIELFDAALVLDHPTVVTSRLDEAALANPTISSQLPPLFNDLIR 1990 Query 1481 RPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDT 1540 RP RR++D+ D ++KS LAQRL+ LA + Q + +VC QAAAVLGRP+ +DVDP+ Sbjct 1991 RPVRRRVDN--DTMAAKSILAQRLNDLAPERQRVAFIEMVCEQAAAVLGRPNGDDVDPEH 2048 Query 1541 EFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQM---------SG 1591 F DLG DSLT +ELRNRLK +GL LPPT+I DHPTP +A Y++Q++ G Sbjct 2049 TFRDLGLDSLTDLELRNRLKIISGLALPPTLIVDHPTPQLLAGYLSQRLGENSDAPTDGG 2108 Query 1592 SRPTESGDPTSQV 1604 SRP+ + DP ++ Sbjct 2109 SRPSPA-DPDDEL 2120 >gi|118463709|ref|YP_881643.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] gi|118164996|gb|ABK65893.1| erythronolide synthase, modules 3 and 4 [Mycobacterium avium 104] Length=4171 Score = 1599 bits (4140), Expect = 0.0, Method: Compositional matrix adjust. Identities = 918/1618 (57%), Positives = 1119/1618 (70%), Gaps = 41/1618 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+SA AL AQA RL +V+A LD DVG +LA R+ FEHRAVVVG R++L+AGL Sbjct 2508 VVSAKSAAALRAQAARLAEYVRAQGELDIADVGWTLAGRATFEHRAVVVGGDRDRLLAGL 2567 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LAA +P A + G GKTV VFPGQG+Q +GMGR+L+ PVFA+AFDAV ELD Sbjct 2568 DELAADDPAASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVFAEAFDAVVAELD 2627 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 RHL PLRDVIWG D ++L+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GEL+A Sbjct 2628 RHLLRPLRDVIWGDDENVLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELSA 2687 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPES 240 AH AGVL+L +AA+LV ARGR MQALP GGAM+AV A+E +V PLLG VGIAA+N P + Sbjct 2688 AHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLGPDVGIAAVNGPAA 2747 Query 241 VVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQLG 300 VVISG AA AIA+R A+G RVH+L+VSHAFHSPLMEPM++EF VAA + +P + Sbjct 2748 VVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLAIDKPVIP 2807 Query 301 LVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIEQ 360 ++SN+TG+ A DFGS +YW HVR VRFADS R Q+ GAT F+E GP SGLT +IE+ Sbjct 2808 IISNLTGQPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFLEVGPSSGLTAAIEE 2867 Query 361 SLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQR 420 +LA A + VS L KDRPE + + A Q + G+ V W G V LPTYAF R Sbjct 2868 TLADAPVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALG--TGHLVDLPTYAFDR 2925 Query 421 RRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVN 480 RRFW + G +DAAGLGL A +HALLGAVVE P S V+LTGRLS A Q WLADH V Sbjct 2926 RRFWLS-GDGAASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSPASQGWLADHAVG 2984 Query 481 GVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRAV 540 GVVLFPGAGFVEL IRAGDEVGC +I+EL LAAPLV+ G V +QVVV D+SG RAV Sbjct 2985 GVVLFPGAGFVELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVVVDGPDDSGARAV 3044 Query 541 SVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGP 600 SV+SR D GWLL+AEG+L +A+ DLS WPP GA VD+ DGY QLAERGY YGP Sbjct 3045 SVFSRADAGAGWLLHAEGVLRAGSAQPATDLSAWPPVGAVPVDLGDGYEQLAERGYRYGP 3104 Query 601 AFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTETR 660 AF+GL ++WRRG E+FAEV P +AGV+ G+HP +LDA LHA+ LA + + Sbjct 3105 AFRGLTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHAVMLASDGDDLPAGSM 3164 Query 661 L-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLR 719 L PF W+ VSLHA GA VRAR A+S+++ D GLPVL+V S+V RP+T +QL Sbjct 3165 LVPFSWQRVSLHAAGAAAVRARIVPVSPSAVSIELADGLGLPVLSVASMVARPVTDQQLL 3224 Query 720 AAVTAAGGASDQGP---LEVVWSPISVVSGGANGSAPPAPVSWADFCA------GSDGDA 770 AAV S+ GP E++WS A S PVS ++ A +D D+ Sbjct 3225 AAV------SNSGPDRLFELIWS--------AQPSTAVQPVSLLNWGATELDATDTDSDS 3270 Query 771 SVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDIS 830 ESA A VV VYAAT L VLQSWL D A TLVV T G + L GED++ Sbjct 3271 GRFAVLFESA-PVAGDVVTEVYAATRAVLPVLQSWLARDGAGTLVVSTRGAMTLPGEDVT 3329 Query 831 DLAAAAVWGMARSAQAENPGRIVLIDTDA---AVDASVLAGVGEPQLLVRGGTVHAPRL- 886 DLA AAVWG+ RSAQ E+PGRIVL+DTDA A + + VGEPQ L+R GTV+ R+ Sbjct 3330 DLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDADAVAAVLAVGEPQTLLRNGTVYTARVL 3389 Query 887 -SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRD 945 S A L +P + WRL GT+E+L ++P P+ APL GQVRVA +A+ NFRD Sbjct 3390 GSRAVGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSALAANFRD 3449 Query 946 VVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQQLVTR 1004 V+ ALG+YP +G E +GVV+ET + +AVGD VMG F G G +A DQ+L+ + Sbjct 3450 VMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTGTVATTDQRLLVK 3509 Query 1005 VPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEV 1064 VP GWS AA VVF TA+Y L DLA+ + G+ VL+HA GGVGMAAVQLAR G+EV Sbjct 3510 VPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAVQLARHLGLEV 3569 Query 1065 FVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLR 1124 F TASRGKWDTLR MGFDDDH+GDSR +FE+KF AVT G G+D+VLDSL+G+ VDASLR Sbjct 3570 FATASRGKWDTLRDMGFDDDHLGDSRGLDFEDKFRAVTGGAGMDIVLDSLSGDSVDASLR 3629 Query 1125 LLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTREL 1184 L+ GG FLEMGKTDIRD + +AA +PGV+YRAFDL EAGP R+ +L E+ +F L Sbjct 3630 LVAPGGIFLEMGKTDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAMFGEDVL 3689 Query 1185 HRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLA 1244 LPVT +DVR APAA R++SQARH+GKVV+TMP D GTV+ITGATG G +A Sbjct 3690 RPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITGATGMAGSAVA 3745 Query 1245 RHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLS 1304 RH+V +G R+LVL SRRG A AAEL A+LT AGA +VVACD ADR A+A + A + Sbjct 3746 RHVVTRHGARNLVLVSRRGLDAPDAAELVAELTAAGAHAEVVACDAADREALAKVIADIP 3805 Query 1305 REYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSS 1364 ++ P+ GVIHAAGVLDDAV+TSLTP RIDTVLRAKVDAAWNLH+ T DLD+ F + SS Sbjct 3806 MQH-PLTGVIHAAGVLDDAVVTSLTPQRIDTVLRAKVDAAWNLHELTRDLDVGAFVMFSS 3864 Query 1365 IAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARM 1424 IA G+ GQGNY+A N+FLDGLAAHR+A GL ISL WGLW+Q MT L + DLAR Sbjct 3865 IAGLAGASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARF 3924 Query 1425 SRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRR 1484 R G+ MS EA+EL D AL +D P + +D AAL + G LP +F L P R Sbjct 3925 GRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVDLINAPTR 3984 Query 1485 RQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGD 1544 RQ+DD+ A SKSAL QRL GL DEQ +L+ LV A VLG S E + PD F + Sbjct 3985 RQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIHPDRAFQE 4044 Query 1545 LGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS--RPTESGDP 1600 LGFDSLTAVE+RNRLK ATGL L PT+IFD+P A+A Y+ +++ G+ +PT + P Sbjct 4045 LGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAP 4102 Score = 1360 bits (3521), Expect = 0.0, Method: Compositional matrix adjust. Identities = 838/1625 (52%), Positives = 1060/1625 (66%), Gaps = 69/1625 (4%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+SA AL AQA RL +V+A LD DVG +LA R+ FEHRAVVVG R++L+AGL Sbjct 474 VVSAKSAAALRAQAARLAEYVRAQGELDIADVGWTLAGRATFEHRAVVVGGDRDRLLAGL 533 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LAA +P A + G GKTV VFPGQG+Q +GM EL PVFAQ A + Sbjct 534 DELAADDPAASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTAPVFAQHIQACEEAFA 593 Query 121 RHLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L D + GA A +D + QPALFAV V+ + + GV PD V+GHS GE+A Sbjct 594 EFVDWSLIDALRGAPGAAGMDRVDVVQPALFAVMVSLAELWKSVGVSPDAVIGHSQGEIA 653 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA+ AG L+L DAA +V R +L+++L G M+++A S + LL G V IAA+N Sbjct 654 AAYVAGALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVN 713 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 +VV+SG AA + +A A R ++ V +A HS +E + E+ A+ ++ R Sbjct 714 GRSAVVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPRS 773 Query 297 PQLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSG 353 ++ S VTG + AG D A YW ++R+ V+F + R G FIE+ P Sbjct 774 SRIAFFSTVTGNRLDTAGLD---ADYWYRNIRQTVQFDQTVRSAAEHGYRTFIESSPHPA 830 Query 354 LTGSIEQSLAPA-----EAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 L IE ++ + EA+V+ LG+D L L +A F GV V W V G+G Sbjct 831 LVAGIEDTVNDSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWRGVLDGAG- 889 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 V+LPTYAF RRRFW + G ADA+GLGLG +EH LL AVVE P S VVLTGRLS Sbjct 890 -FVELPTYAFDRRRFWLS-GEGAAADASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSP 947 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVM---HPGVG-VQ 524 + Q WL DH V+G V+FPGAGFVEL IRAGDEVGC+ +EEL L APL++ G+G V Sbjct 948 SLQGWLTDHAVSGTVVFPGAGFVELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVA 1007 Query 525 VQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDI 584 VQV+VG ADESG R VS++SR D W+ +A+G L + E DL+ WPP GA VDI Sbjct 1008 VQVLVGEADESGRRDVSIFSRPDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGATKVDI 1067 Query 585 SDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLH 644 +DGY +LA RGY YGPAFQGL A W RG E+FAEV P AG V G+HPA+LDA +H Sbjct 1068 ADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAG-GVTGFGVHPALLDAAMH 1126 Query 645 ALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFA------SAGADAISVDVCDAT 698 AL + + + E LPF W+GVSLHA GA VRAR A +A + A+S+++ D Sbjct 1127 ALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRARLAPAQAPGTAASRAVSLELADGL 1186 Query 699 GLPVLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVS 758 GLPVL+VR++V R ++ QLRAAV+AAG EV W+P++V + A+G PP Sbjct 1187 GLPVLSVRAMVARSVSERQLRAAVSAAG---PDRLFEVAWAPVTVPA--AHGE-PPVHQV 1240 Query 759 WADFCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLT 818 + A +GD VG Y TH AL +QSWL + LVV+T Sbjct 1241 FESLAA--EGDP-----------------VGESYRRTHEALAAVQSWLTEHDSGVLVVVT 1281 Query 819 HGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAG---VGEPQLL 875 G + LAGED++DL+ AAVWG+ RSAQ E+PGRIVLID+DAA+D S L GEPQ+L Sbjct 1282 RGAMALAGEDVTDLSGAAVWGLVRSAQTEHPGRIVLIDSDAALDDSALTAALATGEPQVL 1341 Query 876 VRGGTVHAPRLSPAPAL--LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVR 933 +R GTV+ R+ + A+ + P + WRL GT E+L ++P P A LQ GQVR Sbjct 1342 LRDGTVYTARVHGSRAVDGIMTPPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVR 1401 Query 934 VAVAAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAG 992 VA+ A+ NFRDV+ LGM+ A LG EGAGVV+E GP VT+ +VGD+V GF G+G Sbjct 1402 VALRAIATNFRDVMITLGMFTHDAL-LGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSG 1460 Query 993 PLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMA 1052 L D +L+ P WS+ +AA + VF TA+ LA++K G+ VL+HA GGVGMA Sbjct 1461 TLVPGDVRLLQHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMA 1520 Query 1053 AVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLD 1112 AVQLAR G+EVF TASRGKWDTLRAMGFDDDHIGDSRT EFE+KF + T G G+DVVLD Sbjct 1521 AVQLARHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLEFEDKFRSATGGAGMDVVLD 1580 Query 1113 SLAGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEML 1172 SLAGEFVDASLRL+ GG FLEMGKTDIRD +A YPGV+YRAFDL E G RM++ + Sbjct 1581 SLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVVAREYPGVRYRAFDLFEPGRPRMRQWM 1640 Query 1173 AEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVI 1232 E+ LFD L+ LPVTT+D+R AA R++SQARHIGKVV+T+P A L+ GTV+I Sbjct 1641 VELAGLFDAGVLNPLPVTTFDIRRGRAALRYLSQARHIGKVVMTVPGA----LSAGTVLI 1696 Query 1233 TGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVAD 1292 TG TG G LARHLV +GVR L L SR G A GAAE A+L AGA+VQV+ACD AD Sbjct 1697 TGGTGMAGSTLARHLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVIACDAAD 1756 Query 1293 RAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATS 1352 RAA+AG+ A +S E P+ GVIHAAGVLDDA+ITSLTP+RID VLRAKVDAAWNLH+ T Sbjct 1757 RAALAGVIAGISAER-PLSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTR 1815 Query 1353 DLDLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGM 1412 D++LS F + SS+A VGS GQGNY+AAN+FLD LAAHR+A GL ISLAWGLW+Q M Sbjct 1816 DMNLSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAM 1875 Query 1413 TAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALP 1472 T L + DLAR+ R G+ +S EA+ELFD AL +D P +D AL RA A A+P Sbjct 1876 TGGLDAADLARLGRDGILALSSDEAMELFDTALIVDEPFLAPARIDLGAL--RAHAVAVP 1933 Query 1473 ALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPS 1532 +F+ L P RR++DD+ A SKSALA RL GL EQ +L+ LV A VLG P+ Sbjct 1934 PMFADLVNAPTRRRVDDSLAAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPT 1993 Query 1533 AEDVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS 1592 AE +DPD F +LGFDSLTAVE+RNRLKTATGL L PT+IFD+PTP A+A Y+ +++G+ Sbjct 1994 AEAIDPDKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELAGA 2053 Query 1593 RPTES 1597 P E+ Sbjct 2054 -PQET 2057 >gi|254822171|ref|ZP_05227172.1| erythronolide synthase, modules 3 and 4 [Mycobacterium intracellulare ATCC 13950] Length=4177 Score = 1595 bits (4130), Expect = 0.0, Method: Compositional matrix adjust. Identities = 914/1624 (57%), Positives = 1111/1624 (69%), Gaps = 53/1624 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+SA+S AL +QA RL H++A+P LD +DVG +LA RS FE RAV+V R++L+AGL Sbjct 2510 VVSAKSPSALRSQAARLATHLRAHPDLDAVDVGWTLAGRSTFEQRAVIVADDRDRLLAGL 2569 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LAA E + G GKTV VFPGQG+Q +GMGR L+ P+FA+AFDAV ELD Sbjct 2570 DELAADELAQSIIRGTAAPGGKTVFVFPGQGSQLLGMGRGLHDAYPMFAEAFDAVLAELD 2629 Query 121 RHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 +HL PLRDVIWG+D LL++TEFAQPALFAVEVA F +L WG+ PDFVMGHS+GEL+A Sbjct 2630 QHLLRPLRDVIWGSDESLLNTTEFAQPALFAVEVALFRLLESWGIHPDFVMGHSIGELSA 2689 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL----GEGVGIAAIN 236 AHAAGVL+L +AA+LV ARGR MQALPAGGAMVAV A+EDEV PLL + VGIAA+N Sbjct 2690 AHAAGVLSLKNAAVLVAARGRFMQALPAGGAMVAVQATEDEVRPLLVPSEQDSVGIAAVN 2749 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 P SVVISG Q A AIAD+ A+GRRVHQLAVSHAFHSPLM+ M++EF VAA + + Sbjct 2750 GPASVVISGTQGAVTAIADQLRAEGRRVHQLAVSHAFHSPLMDAMIDEFGTVAAGLTIGK 2809 Query 297 PQLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTG 356 P + +VSNVTG LA DFG+A YW HVR VRFADS R + G F+E GP SGLT Sbjct 2810 PTIPIVSNVTGGLATDDFGTAAYWKRHVREAVRFADSVRFVHAAGGNRFLEVGPSSGLTA 2869 Query 357 SIEQSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTY 416 SIE++LA +S L KDRPE + + A F G+ V W + V+LPTY Sbjct 2870 SIEETLADNPVTTMSALRKDRPEPTALVNAVAHGFVAGMAVDWRGAIGTA--NLVELPTY 2927 Query 417 AFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLAD 476 AF RRRFW + D PADAAGLGL EHALLGAVVE P S VVLTGRLS Q WLAD Sbjct 2928 AFDRRRFWLSRD-DAPADAAGLGLAPGEHALLGAVVELPASGGVVLTGRLSSGTQGWLAD 2986 Query 477 HVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESG 536 H V GVVLFPGAGFVEL IRAGDEVGC +++EL LAAPLV+ G V VQVVVG D+SG Sbjct 2987 HAVGGVVLFPGAGFVELAIRAGDEVGCGILDELNLAAPLVLPAGGSVAVQVVVGGPDDSG 3046 Query 537 HRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGY 596 RAVSV+SR + GW L+AEG+L + E DLS WPP GA V++ DGY QLAERGY Sbjct 3047 ARAVSVFSRAEAGSGWSLHAEGVLRAGSVEPGADLSAWPPAGAVPVEVGDGYEQLAERGY 3106 Query 597 AYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQ-A 655 YGPAF+GL ++WRRG E+FAEV P +AGV+V G+HP +LDA LHA+ L+ E + A Sbjct 3107 GYGPAFRGLTSMWRRGDEIFAEVTLPSDAGVSVSGFGVHPVLLDAALHAVILSSESDELA 3166 Query 656 STETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITA 715 +PF W+ VSLHA GA VRAR GA A+S+++ D GLPVL+V S+V RP+T Sbjct 3167 PGSILVPFSWQQVSLHAAGAAAVRARIMPVGASAVSIELADGLGLPVLSVASMVARPVTD 3226 Query 716 EQLRAAVTAAGGASDQGP---LEVVWS--------PISVVSGGANGSAPPAPVSWADFCA 764 +QL AAV S+ GP E++WS P+SV + GA SA ++ Sbjct 3227 QQLLAAV------SNSGPDRLFELIWSAQPTSTVQPVSVSAWGAPESA--------EYDN 3272 Query 765 GSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGL 824 G G SVV++E E G V+ VYAAT L VLQSWL D TLVV T G + L Sbjct 3273 GEAG-LSVVLFESEPVSGD---VITEVYAATRAVLPVLQSWLSRDVTGTLVVATRGAMTL 3328 Query 825 AGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGV---GEPQLLVRGGTV 881 GED++DLA AAVWG+ RSAQ E+PGRIVL+DTDA +D +A V GEPQ L R G V Sbjct 3329 PGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDPDAIAAVLAVGEPQALRRNGMV 3388 Query 882 HAPRL--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAV 939 + R+ S A L P + WRL GT+E+L I+ P+ APL GQVRVA++A+ Sbjct 3389 YTARVLGSRAVGGLLTPPEQGPWRLGMSSYGTIENLRIERIPDADAPLGPGQVRVALSAI 3448 Query 940 GVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVD 998 NFRDV+ ALG+YP +G E AGV+ ET + VGD VMG F G G +A D Sbjct 3449 AANFRDVMIALGLYPDPDAIMGIEAAGVITETASQDGRFEVGDRVMGLFPDGTGTIAKTD 3508 Query 999 QQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLAR 1058 ++L+ +VP GWS AA VVF TA Y L DLA K G+ VL+HA GGVGMAAVQLAR Sbjct 3509 ERLLVKVPAGWSHTAAATASVVFATARYALVDLAAAKPGQRVLVHAAAGGVGMAAVQLAR 3568 Query 1059 QWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGR----GVDVVLDSL 1114 Q G+EVF TASRGKWDTLRAMGFDDDHIGDSR+ EFE+KF AVT GR G+D+VLDSL Sbjct 3569 QIGLEVFATASRGKWDTLRAMGFDDDHIGDSRSLEFEDKFRAVT-GRTGTAGMDIVLDSL 3627 Query 1115 AGEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAE 1174 +GEFVDASLRL+ GG FLEMGKTDIRD + +A ++ GV+YRAFDL EAGP R+ +ML E Sbjct 3628 SGEFVDASLRLVAPGGVFLEMGKTDIRDPEVVARDHSGVRYRAFDLFEAGPDRIAQMLDE 3687 Query 1175 VRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITG 1234 + +F L LPVT +DVR APAA R++SQARH+GKVV+TMP D GTV+ITG Sbjct 3688 LAAMFAEDVLRPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITG 3743 Query 1235 ATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRA 1294 ATG G +ARH+V +G R++VL SRRG A GAAEL A+L AGA + VACD ADR Sbjct 3744 ATGMAGSAVARHVVTRHGARNVVLVSRRGLDAPGAAELVAELRAAGAHAEAVACDAADRE 3803 Query 1295 AVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDL 1354 A+A + A + + P + GVIHAAGVLDDAV+TSL P+R+ VLR+KVDAAWNLH+ T DL Sbjct 3804 ALAKVIADIPMQRP-LTGVIHAAGVLDDAVVTSLNPERMAAVLRSKVDAAWNLHELTRDL 3862 Query 1355 DLSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTA 1414 D+S F + SSIA G+ GQ NY+A N+FLDGLAAHR+A GL ISL WGLW+Q MT Sbjct 3863 DVSAFVMFSSIAGLAGASGQANYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTG 3922 Query 1415 HLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPAL 1474 L + DLAR R G+ MS +A+EL D AL +D P + +D AAL + +G LP + Sbjct 3923 GLGAADLARFGRDGIVAMSSEQALELMDTALIVDEPFMLPAHIDLAALRVKFDSGTLPPM 3982 Query 1475 FSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAE 1534 F L P RRQ+DD+ A SKSAL QRL GL DEQ +L+ LV A VLG S E Sbjct 3983 FVDLINAPTRRQVDDSLTAAKSKSALLQRLEGLPEDEQQAILLDLVRSHIATVLGSSSPE 4042 Query 1535 DVDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRP 1594 + PD F +LGFDSLTAVE+RNRLK ATGL L PT+IFD+P A+A Y+ +++ G+ Sbjct 4043 AIHPDRAFQELGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMHRELVGASE 4102 Query 1595 TESG 1598 G Sbjct 4103 QTPG 4106 Score = 1348 bits (3489), Expect = 0.0, Method: Compositional matrix adjust. Identities = 827/1631 (51%), Positives = 1043/1631 (64%), Gaps = 65/1631 (3%) Query 2 ISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGLA 61 +SA+SA AL AQA RL +++A+ LD DVG +LA R+ FEHRAV+V R++L+AGL Sbjct 476 LSAKSARALAAQAARLAEYLRAHHELDVADVGWTLAGRATFEHRAVIVADDRDRLLAGLD 535 Query 62 GLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDR 121 LA +P V G GKTV VFPGQG+Q +GMG EL PVFAQ A + Sbjct 536 ELANDDPTGTVLRGIATPAGKTVFVFPGQGSQWLGMGIELLDTAPVFAQQIQACEEAFAE 595 Query 122 HLRLPLRDVIWGAD-ADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAA 180 + L DV+ GA A +D + QP LFAV V+ + + GV PD V+GHS GE+AA Sbjct 596 FVDWSLIDVLRGAPGAPGMDRVDVVQPVLFAVMVSLAELWKSVGVSPDAVIGHSQGEIAA 655 Query 181 AHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAINA 237 A+ AG L+L DA +V R +L+++L G M+++A S + LL G V IAA+N Sbjct 656 AYVAGALSLRDAVRVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGSRVSIAAVNG 715 Query 238 PESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREP 297 +VV+SG AA + + A R ++ V +A HS +E + ++ A+ + ++ R Sbjct 716 RSAVVVSGDVAALDELVGFCADLELRTRRIDVDYASHSVEVEAIRDDLAQALSGIEPRSS 775 Query 298 QLGLVSNVTG---ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGL 354 ++ S VTG + AG D A YW ++R+ V+F + R G FIE+ P L Sbjct 776 RIAFFSTVTGNRLDTAGLD---ADYWYRNIRQTVQFDQAVRSASEHGYRTFIESSPHPAL 832 Query 355 TGSIEQSLA--------PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGS 406 IE + +EA V+ LG+D L L + F GV V W V G+ Sbjct 833 VAGIEDTANHHAGRDAEASEAKVIPTLGRDDGGLDRFLTSVATAFVAGVSVGWRGVLDGA 892 Query 407 GGRRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRL 466 G V+LPTYAF RRRFW + G ADA GLGLGA+EH LL AVVE P S VVLTGRL Sbjct 893 G--FVELPTYAFDRRRFWLS-GEGAAADATGLGLGASEHPLLSAVVELPSSGGVVLTGRL 949 Query 467 SLADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVG---- 522 S + Q WL DH V+G V+FPGAGFVEL IRAGDEVGC+ ++EL L APL M P G Sbjct 950 SPSLQGWLTDHAVSGAVVFPGAGFVELAIRAGDEVGCSTVDELTLQAPL-MLPAKGSGAG 1008 Query 523 -VQVQVVVGAADESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAES 581 V VQVVVG A E+G R VS++SR D GW+ +AEG L + E DLS WPP GA + Sbjct 1009 SVAVQVVVGPATETGQRVVSIFSRPDTGSGWVCHAEGTLSTGSVEPGADLSAWPPAGAVA 1068 Query 582 VDISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDA 641 VD +DGY QLA RGY YGPAFQGL A W RG E+FAEV P AG +V+ G+HPA+LDA Sbjct 1069 VDPADGYEQLAARGYGYGPAFQGLTAAWVRGDEIFAEVRLPDAAG-SVNGFGVHPALLDA 1127 Query 642 VLHALGLAVEKTQASTETRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLP 701 +HAL + + + E LPF W+GVSLHA GA VRAR A AGA A+S+++ D GLP Sbjct 1128 AMHALVIGHQMADHTDEVVLPFFWQGVSLHAAGASAVRARIAPAGASAVSIELADGLGLP 1187 Query 702 VLTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWAD 761 VL+VR++V R ++ QLRAAV+A+G EV WSP + GA G PP V Sbjct 1188 VLSVRAMVARSVSERQLRAAVSASG---PDRLFEVEWSP---ATAGA-GETPPHEV---- 1236 Query 762 FCAGSDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGG 821 ES + + GS Y TH AL ++SWL + LVV T G Sbjct 1237 ---------------FESLAAEEDPITGS-YRRTHEALAAVRSWLSERDSGLLVVATRGA 1280 Query 822 VGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLA---GVGEPQLLVRG 878 +GLAGED+ DLA AAVWG+ RSAQ E+PGRIVL+D+D A+D S +A VGEPQ+L+R Sbjct 1281 MGLAGEDVPDLAGAAVWGLVRSAQTEHPGRIVLVDSDVALDDSAIATALAVGEPQVLLRD 1340 Query 879 GTVHAPRLSPAPAL--LALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAV 936 G H R+ + A+ + P WRL GT E+L ++P P APL+ GQVRVA+ Sbjct 1341 GKAHTARVRGSRAVGGIMTPPESGPWRLGISSAGTFENLQLEPVPNADAPLEPGQVRVAL 1400 Query 937 AAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFL-GGAGPLA 995 A+ NFRDV+ LGM+ +A LG EGAGVV+E GP VT+ VGD+V GF G+G L Sbjct 1401 RAIATNFRDVMITLGMFTHEAL-LGGEGAGVVVEVGPGVTEFEVGDSVYGFFPDGSGTLV 1459 Query 996 VVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQ 1055 D +L+ R P WS+A+AA + VF TA+ LAE++ G+ VL+HA GGVGMAAVQ Sbjct 1460 PGDVRLLQRKPADWSYAEAAGISAVFTTAYMAFIHLAEVQPGQRVLVHAAAGGVGMAAVQ 1519 Query 1056 LARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLA 1115 LAR G+EVF TASRGKWDTLRAMGFDDDHI DSR+ EFE+KF +VT G G+DVVLDSLA Sbjct 1520 LARHLGLEVFATASRGKWDTLRAMGFDDDHISDSRSLEFEDKFRSVTGGAGMDVVLDSLA 1579 Query 1116 GEFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEV 1175 GEFVDASLRL+ GG FLEMGKTDIRD +A YP V+YRAFDL E G RM + + E+ Sbjct 1580 GEFVDASLRLVAPGGMFLEMGKTDIRDPGAVAQEYPDVRYRAFDLFEPGRPRMHQWMIEL 1639 Query 1176 RELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGA 1235 LFD L LPVTT+DVR AA R++SQARHIGKVV+T+P+ LA GTV+ITG Sbjct 1640 AGLFDAGVLEPLPVTTFDVRRGRAALRYLSQARHIGKVVMTVPTGPGAGLASGTVLITGG 1699 Query 1236 TGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAA 1295 TG G LARHLV +GV L L SRRG A GAAEL A+L AGA+ +V+ACD ADR A Sbjct 1700 TGMAGSTLARHLVAHHGVEDLALLSRRGPDAPGAAELIAELEAAGARARVIACDAADRTA 1759 Query 1296 VAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLD 1355 +A + +LS P+ GVIHAAGVLDDA++TSLTP+RID VLR+K+DAAWNLH+ T DL+ Sbjct 1760 LAAVITELSATR-PLSGVIHAAGVLDDAMLTSLTPERIDAVLRSKIDAAWNLHELTRDLN 1818 Query 1356 LSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAH 1415 LS F + SS+A VGS GQGNY AAN+FLD LAAHR+A GL ISL WGLW+Q MT Sbjct 1819 LSAFVMFSSMAGLVGSSGQGNYGAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGG 1878 Query 1416 LSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALF 1475 L + DLAR+ R G+ +S EA+ELFD AL +D P +D AL RA A A+P +F Sbjct 1879 LDAADLARLGRDGILALSSDEAMELFDTALIVDEPFLAPARIDLGAL--RAHAVAVPPMF 1936 Query 1476 SGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAED 1535 + L P RR++DD+ A SKSALA RL GL+ EQ +L+ LV A VLG SAE Sbjct 1937 ADLVNAPTRRRVDDSLAAAKSKSALAHRLDGLSEAEQHAVLLDLVRSHIATVLGNTSAEA 1996 Query 1536 VDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPT 1595 +DPD F +LGFDSLTAVE+RNRLKTATGL L PT+IFD+PTP +A Y+ +++G+ Sbjct 1997 IDPDKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNGLAGYIRTELAGAPQE 2056 Query 1596 ESGDPTSQVVE 1606 P ++ E Sbjct 2057 IKHAPVARATE 2067 >gi|183982486|ref|YP_001850777.1| polyketide synthase, Pks8 [Mycobacterium marinum M] gi|183175812|gb|ACC40922.1| polyketide synthase, Pks8 [Mycobacterium marinum M] Length=2114 Score = 1588 bits (4112), Expect = 0.0, Method: Compositional matrix adjust. Identities = 932/1597 (59%), Positives = 1115/1597 (70%), Gaps = 42/1597 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLA-SRSVFEHRAVVVGASREQLIAG 59 V+SARSA AL QA RL++ + +P LDP+DVG SLA +RS+FEHRAVVVG R QL+ G Sbjct 475 VLSARSAPALANQAQRLLSWAEEHPDLDPVDVGWSLAATRSLFEHRAVVVGTDRTQLMDG 534 Query 60 LAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LAG+ AGEPGAGV VG+ S GKTV VFPGQGAQ +GMGR LY F+ AFDA A EL Sbjct 535 LAGVVAGEPGAGVVVGRARSTGKTVFVFPGQGAQYLGMGRVLYERFSAFSTAFDAAAAEL 594 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 D HLRLPLR V+WG D LL+STEFAQPALFAVEVA A+L GV+PD V+GHSVGE++ Sbjct 595 DAHLRLPLRQVMWGTDEGLLESTEFAQPALFAVEVALAALLSQLGVVPDLVLGHSVGEIS 654 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AAH AGVL+L DAA LV ARGRLM L AGGAMVAVAASE EV PLLG GV +AA+N P+ Sbjct 655 AAHVAGVLSLPDAARLVAARGRLMAGLAAGGAMVAVAASEQEVTPLLGSGVAVAAVNGPD 714 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 SVVISG +AA + DR AA GRR H+LAVSHAFHS LM+PML +FA V V A +P++ Sbjct 715 SVVISGPEAAVGEVVDRIAALGRRTHRLAVSHAFHSELMDPMLPDFAEVLKGVSASQPRI 774 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 LVSNVTG+LA +GSA YWV+HVR+PVRFADS ++LGA F+E GP GLT +E Sbjct 775 SLVSNVTGQLAEAGYGSAAYWVEHVRKPVRFADSVALAESLGAAAFVEVGPSGGLTALVE 834 Query 360 QSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQ 419 QSL E V +L KDRPE + L GQ+F G + W FAG G +R LPTY F Sbjct 835 QSLT-RETPAVPLLIKDRPENDALLLGLGQLFADGRALDWREAFAGLGAQRTDLPTYGFV 893 Query 420 RRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRR+W G GL H LLGAVVERPD +VLTG LS PWL DH V Sbjct 894 RRRYWLKELGVDQTKLTGAGLTGVGHPLLGAVVERPDVGGLVLTGVLSPELHPWLRDHTV 953 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 +GVVLFPGAGFVEL +RAGDEVGC L++EL L APL + V++Q+VVG ADESG R Sbjct 954 DGVVLFPGAGFVELALRAGDEVGCPLVQELTLLAPLALPQTGTVRMQLVVGGADESGRRT 1013 Query 540 VSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAYG 599 VSV+S W+L+AEG+L + +DLSVWPP GA +VD+SD Y + A RGY YG Sbjct 1014 VSVFSSTADGDSWVLHAEGVLRASGVGHGVDLSVWPPVGASAVDVSDVYDRFAARGYGYG 1073 Query 600 PAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTET 659 PAF+GL ++WRRG E++AEVVAP +A V G+HPAVLDA LHA G A A+ + Sbjct 1074 PAFRGLRSVWRRGREIYAEVVAPEDA--TVQGFGIHPAVLDAALHAWGFAT----ATDQL 1127 Query 660 RLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQLR 719 LPF W+GVSLHA GA R+R R A A ++S+++ D GLPVL+V+ LV R ++ E L Sbjct 1128 MLPFSWQGVSLHAAGAARLRVRITPADAGSVSLELADPRGLPVLSVKQLVVRAVSGEALS 1187 Query 720 AAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELES 779 AAV AAGG LEV W P S + SD VVVWE S Sbjct 1188 AAVIAAGGTISGRLLEVAWPPTS------------------PELSASDSARDVVVWESGS 1229 Query 780 AGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVWG 839 A G +V + AL LQSWL D LVVLT G VGLAGE ++DLA AAVWG Sbjct 1230 ADGDV-----AVGQRVNEALAKLQSWLAGDDPGVLVVLTRGAVGLAGEGVTDLAGAAVWG 1284 Query 840 MARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPALLALPAAE 899 + RSAQAE+PGR+VL+DTD +VD + GEPQL+VR G VH RL + L E Sbjct 1285 LTRSAQAEHPGRVVLVDTDDSVDIADAVACGEPQLVVRSGVVHGARLRFIDSGSGLELPE 1344 Query 900 SAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQAPP 959 WRLA GGGGTLED+++QPCP +A L AGQVRVAV A GVNFRDV+ ALGMYPG Sbjct 1345 GPWRLAVGGGGTLEDVLVQPCP--RADLAAGQVRVAVGAAGVNFRDVLVALGMYPGGG-A 1401 Query 960 LGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPV 1019 LGAEGAGVV+E GP V LAVGDAVMG +G G AVVD++LVT VP GWS AQAA VPV Sbjct 1402 LGAEGAGVVVEVGPGVEGLAVGDAVMGLVGVVGSEAVVDERLVTTVPAGWSLAQAAGVPV 1461 Query 1020 VFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAM 1079 VFLTA+YGL+ LA +KAGE VLIHAG GGVGMAAV LA+ WG E+FVTASRGKWDTLRAM Sbjct 1462 VFLTAFYGLSVLAGLKAGERVLIHAGAGGVGMAAVALAKYWGAEIFVTASRGKWDTLRAM 1521 Query 1080 GFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMGKTD 1139 GFDD+HIGDSR+ EFEEKF + G GVDVVL+SLAGEF DASLRLLV GGRF+EMGKTD Sbjct 1522 GFDDEHIGDSRSLEFEEKFRKTSGGAGVDVVLNSLAGEFTDASLRLLVSGGRFIEMGKTD 1581 Query 1140 IRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRCAPA 1199 +RD Q +A YPGV YRAFDL EAGP + ML+EV L L P+ +DVR A Sbjct 1582 LRDPQAVADEYPGVSYRAFDLMEAGPDAIARMLSEVVGLLQEGILKAPPLKLFDVRSAQQ 1641 Query 1200 AFRFMSQARHIGKVVLTMPSALADR--LADGTVVITGATGAVGGVLARHLVGAYGVRHLV 1257 A+R++SQARHIGKVVLT+P A + L+ GTV+ITG TG G +ARHLV YGV H+V Sbjct 1642 AYRYVSQARHIGKVVLTLPQGPAAQSVLSGGTVLITGGTGMAGAAVARHLVQRYGVGHVV 1701 Query 1258 LASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAA 1317 L SR G +A G A+L A+L + GA+V V ACDVADR AVA L AQL Y P++G+ HAA Sbjct 1702 LVSRAGTQAPGIADLVAELQQGGAQVSVTACDVADRDAVAALLAQLPDRY-PLKGIFHAA 1760 Query 1318 GVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGNY 1377 GVLDDAV+ SLTPDR++ VLRAK AWNLH+ T +DL+ F + SS+A G+PGQGNY Sbjct 1761 GVLDDAVLASLTPDRVEPVLRAKAAGAWNLHELTHGMDLAAFVMFSSLAGIAGAPGQGNY 1820 Query 1378 SAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEA 1437 +AANAFLDGLAA+R+ L +S+AWGLWEQP MT HL RDLARM + GL P+S A Sbjct 1821 AAANAFLDGLAAYRRGQDLPAVSIAWGLWEQPSTMTQHLGDRDLARMRQVGLDPLSTEHA 1880 Query 1438 VELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSK 1497 + L DAAL + P VA L+ AAL A + +P ++ L R RR + D D ++S Sbjct 1881 LHLLDAALLGERPGVVAAQLNVAALSANPE---VPPIWRDLVTRSVRRVV-DANDNSASM 1936 Query 1498 SALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRN 1557 +AL RLH L+ +++ LV ++C AA VLG S D+D + F DLGFDSLTAVELRN Sbjct 1937 TALISRLHTLSPEQRSRELVDMICTNAATVLGNASV-DIDANKPFQDLGFDSLTAVELRN 1995 Query 1558 RLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRP 1594 RLK++TGLTL PT+IFD+PTP A+AE+++ Q+S P Sbjct 1996 RLKSSTGLTLSPTLIFDYPTPAALAEHLSTQLSSLSP 2032 >gi|183980137|ref|YP_001848428.1| polyketide synthase PKS [Mycobacterium marinum M] gi|183173463|gb|ACC38573.1| polyketide synthase PKS [Mycobacterium marinum M] Length=2197 Score = 1580 bits (4091), Expect = 0.0, Method: Compositional matrix adjust. Identities = 904/1622 (56%), Positives = 1111/1622 (69%), Gaps = 33/1622 (2%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGL 60 V+S +S A+ AQA RL+A VQA+ GLD +DVG SLA R+ FE+RAVV+G R+QLI+GL Sbjct 490 VVSGKSEAAVAAQAKRLLAAVQADEGLDRLDVGFSLARRTAFEYRAVVLGEDRQQLISGL 549 Query 61 AGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELD 120 LAAG+PG V G+ +V KTV+VFPGQG+Q GMGREL PVFA+ A+ L Sbjct 550 TELAAGQPGPTVLNGRAATVSKTVMVFPGQGSQWPGMGRELLAASPVFAEHMRLCAEALG 609 Query 121 RHLRLPLRDVIWG-ADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 + L DV+ G A A LD + QP L+A+ V+ + R GV+PD V+GHS GE+A Sbjct 610 EFVDWSLLDVVNGVAGAPTLDRVDVVQPVLWAMMVSLAQLWRSVGVVPDAVIGHSQGEIA 669 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL---GEGVGIAAIN 236 AA AG L+L D A +V R R + L G MVA+A + V LL G+ + +AA+N Sbjct 670 AACVAGALSLRDGAAVVALRSRALVDLAGTGGMVAIACGVERVRELLADYGDRLSLAAVN 729 Query 237 APESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQARE 296 +VV+SG A + R A+G R ++ V +A HS +E + A V+ R Sbjct 730 GVAAVVVSGEAKALRGLTGRCEAEGMRARRIEVDYASHSAQVESIGSSLVEALAGVRPRS 789 Query 297 PQLGLVSNVTG-ELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLT 355 + VS VTG + G G A YW ++R+ VRF + R+ G F+EA P L Sbjct 790 SDIEFVSTVTGASVDGASLG-ADYWYRNIRQTVRFDRAVRYCHEQGCRTFVEASPHPVLL 848 Query 356 GSIEQSLA-------PAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGG 408 IE+SLA A +V+ LG++ + + Q + GV V WSAVFAGSGG Sbjct 849 AGIEESLAEGIGRPDSAGVIVIPTLGRNEGGVERFWMSLSQAWLAGVGVDWSAVFAGSGG 908 Query 409 RRVQLPTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSL 468 R+V LPTYAF RRRFW G+ AD GL A HALLGAVVE+PD+ VVLTGRLSL Sbjct 909 RQVGLPTYAFARRRFW-LDGSASAADVGEAGLVAAGHALLGAVVEQPDTGAVVLTGRLSL 967 Query 469 ADQPWLADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVV 528 A QPWLADH+V G VLFPG GFVEL IRAGDEVGC ++EEL LA PLV++ G VQVQVV Sbjct 968 ARQPWLADHLVGGAVLFPGTGFVELAIRAGDEVGCGVVEELTLATPLVLNAGTAVQVQVV 1027 Query 529 VGAADESGHRAVSVYSRGDQ-SQGWLLNAEG----MLGVAAAETPMDLSVWPPEGAESVD 583 VG+A +SG R VS+YSR DQ Q W+L+A+G AA +LS WPP GAE+VD Sbjct 1028 VGSAGQSGQRLVSMYSRADQPDQHWVLHAQGSVAPAAVQPAAAASAELSTWPPAGAEAVD 1087 Query 584 ISDGYAQLAERGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVL 643 I Y +LA RGY YGPAFQGL A+WRRG ++FAEV P + G+ + +G+HPA+LDA L Sbjct 1088 IGGLYERLARRGYGYGPAFQGLRAVWRRGRDVFAEVGLPNDDGLDLTDVGIHPALLDAAL 1147 Query 644 HALGLAVEKTQASTE-TRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPV 702 HA L V E T LPF W+ +SLH GA R+R R A AG A+SV++ D GLPV Sbjct 1148 HAW-LCVGGFGGDGEATVLPFSWQHLSLHGSGASRLRVRIAPAGPSAVSVELADGAGLPV 1206 Query 703 LTVRSLVTRPITAEQLRAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADF 762 L+V SL TRP+ A QL+AA++A G + + L VVW+PI+ VSW DF Sbjct 1207 LSVGSLTTRPVGAAQLQAAMSAGGDGTGRELLNVVWTPITFERDSVQRDGERRVVSWDDF 1266 Query 763 CAGS-----DGDASV-VVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVV 816 AG D D V VVW+ ES G A SVV +VY ATH LEVLQ WL D A LVV Sbjct 1267 LAGRCAAARDLDRDVAVVWQWESGG--AESVVNTVYTATHRVLEVLQRWLADDLPAVLVV 1324 Query 817 LTHGGVGLAGEDISDLAAAAVWGMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLV 876 T G +GLAGE I+DLA AAVWG+ RSAQ E+PGRIVLIDTD ++ + GVGEPQL+V Sbjct 1325 CTRGAMGLAGEAITDLAGAAVWGLVRSAQTEHPGRIVLIDTDTSMALPTVIGVGEPQLVV 1384 Query 877 RGGTVHAPRLSPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAV 936 R G V+A RL+ A L P A W+LAA GGGT +D+V++PCP PL GQVRVA+ Sbjct 1385 RAGDVYAARLARGRAALRTPDAGQGWQLAATGGGTFDDVVLEPCPRSDEPLAVGQVRVAL 1444 Query 937 AAVGVNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAV 996 AA+GVNFRDV+ LG+YPG P LG EGAGVV+E GP V+ L GD V+G + G V Sbjct 1445 AALGVNFRDVLVVLGLYPGNKPTLGGEGAGVVVEVGPGVSGLEPGDRVLGLMSGRSE-CV 1503 Query 997 VDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQL 1056 VDQ+L+ +P GWSFA+AA+ P+VFLTA+YGL+DLA ++ GESVL+HA TGGVGMAA+QL Sbjct 1504 VDQRLLVPIPAGWSFAEAASAPIVFLTAFYGLSDLAGLRRGESVLVHAATGGVGMAAIQL 1563 Query 1057 ARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAG 1116 AR WG VFVTASRGKWDTLRAMGFDDD I DSRT EFEEKF A T GRG+DVVL++LAG Sbjct 1564 ARLWGARVFVTASRGKWDTLRAMGFDDDQIADSRTLEFEEKFSAATGGRGIDVVLNALAG 1623 Query 1117 EFVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDL-SEAGPARMQEMLAEV 1175 EF DASLRLL GRF+EMGKTDIRDAQE+A +PGV YRAFDL +E P R+ +MLAE+ Sbjct 1624 EFTDASLRLLAERGRFIEMGKTDIRDAQEVAQEHPGVSYRAFDLANEVAPQRLGQMLAEL 1683 Query 1176 RELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGA 1235 LF +LHRLPV TWDVRCAP A++F+SQARHIGKVVL+ P+ L D LA GTV+ITG Sbjct 1684 MTLFAAGKLHRLPVKTWDVRCAPQAYQFVSQARHIGKVVLSAPTELRDALAAGTVLITGG 1743 Query 1236 TGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAA 1295 TG VG VLARHLV AYGVR+LVL SR G++ G AEL +L++AGA+V V ACDVAD++A Sbjct 1744 TGLVGSVLARHLVSAYGVRNLVLVSRMGEQGAGVAELVDELSDAGARVLVAACDVADQSA 1803 Query 1296 VAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLD 1355 V L A REYP + GVIHAAGVLDDAVITS+TPD++D+VLRAKVD AWNLH AT L Sbjct 1804 VEKLIAGWGREYPALTGVIHAAGVLDDAVITSMTPDQVDSVLRAKVDGAWNLHHATRGLG 1863 Query 1356 LSMFALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAH 1415 LSMF LCSSIA VG+PGQGNY+AANAFLD L R+A GLAG+SL WGLWEQ GMT H Sbjct 1864 LSMFVLCSSIAGVVGAPGQGNYAAANAFLDALVTDRRAHGLAGVSLGWGLWEQASGMTKH 1923 Query 1416 LSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALF 1475 L D++R+SR G A +S +A++LFDAAL +D P +A LDR AL+ A LP LF Sbjct 1924 LRGSDVSRLSRGGFAAISAQQALDLFDAALIVDQPTVLAARLDRRALENPALNADLPTLF 1983 Query 1476 SGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAED 1535 S L RP RR +D+ D T ++ AL RL+ + DEQ +LL +VC QA VLGR +A D Sbjct 1984 SDLITRPMRRNVDN--DGTPTELALVNRLNMMNPDEQHDLLTEVVCTQAVMVLGRLNAAD 2041 Query 1536 VDPDTEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGSRPT 1595 +DP+ F DLGFDSLTA+ELRNRLKT TGLTLPPT+IFDH P+A+A+++ QQ+ + Sbjct 2042 IDPNATFSDLGFDSLTAIELRNRLKTVTGLTLPPTLIFDHRAPSALAQHLGQQLCVTHQH 2101 Query 1596 ES 1597 ES Sbjct 2102 ES 2103 >gi|296164561|ref|ZP_06847131.1| erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295900085|gb|EFG79521.1| erythronolide synthase, modules 3 and 4 [Mycobacterium parascrofulaceum ATCC BAA-614] Length=2122 Score = 1573 bits (4073), Expect = 0.0, Method: Compositional matrix adjust. Identities = 962/1594 (61%), Positives = 1130/1594 (71%), Gaps = 52/1594 (3%) Query 1 VISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLAS-RSVFEHRAVVVGASREQLIAG 59 V+SARSA+AL AQA RL A++ A PGL P DVG SLA+ R+ EHRAV+VG+ R+ L AG Sbjct 490 VVSARSADALAAQAARLSAYLDAEPGLRPRDVGWSLATTRAALEHRAVLVGSDRDTLRAG 549 Query 60 LAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADEL 119 LAG+A+GEPG G VG+ S GK VFPGQGAQR+GMGREL+ P FA+AFD + Sbjct 550 LAGVASGEPGPGAVVGRSRSTGKRAFVFPGQGAQRLGMGRELHQRFPAFAEAFDEAVAAV 609 Query 120 DRHLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELA 179 D H R PLR+V+WG D +LL STEFAQPALF +EVA A+ R WGV PD V+GHSVGE+A Sbjct 610 DAHARRPLREVMWGTDPELLQSTEFAQPALFVLEVALAALWRSWGVTPDVVIGHSVGEIA 669 Query 180 AAHAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEGVGIAAINAPE 239 AAH AGVL+L DAA LV ARGRLM ALP GG MVAV A+E EV PLL GV +AA+N P Sbjct 670 AAHVAGVLSLRDAARLVAARGRLMAALPPGGVMVAVTATEAEVAPLLDGGVSLAAVNGPA 729 Query 240 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREPQL 299 +VV+SG + A A ADR A GRRV QLAVSHAFHSPLMEPM+EEF+ VAA V P++ Sbjct 730 AVVLSGERDAVTAAADRLADCGRRVRQLAVSHAFHSPLMEPMIEEFSAVAAGVSPGSPRI 789 Query 300 GLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGSIE 359 LVSNVTG AGP +GSA YWV+HVRRPVRFAD AR LGA F+E GPG+ LT ++E Sbjct 790 DLVSNVTGRPAGPGYGSADYWVEHVRRPVRFADGARCAAALGAGAFVEVGPGAALTAAVE 849 Query 360 QSLAPAEAMVVSMLGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQ 419 QSL A+ + KD PE+ S L AAGQ+F +G + W+A FAG RV LPTYAF Sbjct 850 QSLGAEPAVAAVSMAKDHPEVDSLLLAAGQLFASGADLDWAAAFAGLAAHRVDLPTYAFA 909 Query 420 RRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVV 479 RRRFW + G D AGLGL A HALLGAVVERPDS VVLTGRLS QPWLADH V Sbjct 910 RRRFWLLSESVGGRDTAGLGLAAAGHALLGAVVERPDSGGVVLTGRLSTVAQPWLADHAV 969 Query 480 NGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAADESGHRA 539 G VLFPGAGFVEL++RAGDEVGC +IEEL+L+APL + V VQVVV A E G RA Sbjct 970 AGTVLFPGAGFVELMLRAGDEVGCPVIEELMLSAPLPLPAAGAVCVQVVVDGAGEGGSRA 1029 Query 540 VSVYSR-GDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAERGYAY 598 +VYS+ G Q W L+A+G+LG + DLSVWPP GA +VD++ Y LA RGY Y Sbjct 1030 AAVYSQAGSQ---WTLHAQGVLGEGSPAPDADLSVWPPVGATAVDVAGAYDDLAGRGYGY 1086 Query 599 GPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKTQASTE 658 GPAF+GL A+WRRG+E+FAEV AP +AGVAV G+HP VLDA LHALG+A E E Sbjct 1087 GPAFRGLRAVWRRGAEVFAEVEAPQDAGVAVGGFGIHPVVLDAALHALGVADE----GAE 1142 Query 659 TRLPFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRPITAEQL 718 T LPF W+GV LHA GA RVR R A AG DA+SV++ D++GLPVL+VR LVTRP++A QL Sbjct 1143 TVLPFSWQGVCLHAAGASRVRVRLAPAGKDAVSVELADSSGLPVLSVRELVTRPVSAAQL 1202 Query 719 RAAVTAAGGASDQGPLEVVWSPISVVSGGANGSAPPAPVSWADFCAGSDGDASVVVWELE 778 AA A G + LE VWSP+++ + PAP W G DG Sbjct 1203 SAAAAARTGGGEL--LEAVWSPVAL----PDNPDGPAPEVWRPPANG-DG---------- 1245 Query 779 SAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLAGEDISDLAAAAVW 838 VV SV+AATH AL +LQS + +A LVVLT G V L GED++DLA AAVW Sbjct 1246 --------VVASVHAATHAALGLLQSR--DEGSAPLVVLTRGAVALPGEDVTDLAGAAVW 1295 Query 839 GMARSAQAENPGRIVLIDTDAAVDASVLAGVGEPQLLVRGGTVHAPRLSPAPA--LLALP 896 G+ RSAQAENPGR+VL+D+D ++D + G GEPQL+VRGG H RL+P +L LP Sbjct 1296 GLVRSAQAENPGRVVLVDSDGSLDPRAVVGCGEPQLVVRGGVAHRARLAPVKVHPVLRLP 1355 Query 897 AAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAALGMYPGQ 956 S WRLAAG GTLEDL +Q P + L AGQVRVAVAA GVNFRDV+ ALGMYPG Sbjct 1356 EPPSVWRLAAGDAGTLEDLAVQSGPPAE--LLAGQVRVAVAAAGVNFRDVLVALGMYPGA 1413 Query 957 APPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGGAGPLAVVDQQLVTRVPQGWSFAQAAA 1016 A LGAEGAG+V E GP VTDLAVGDAV+G LG G AVVD++LVTRVP WS A+AA Sbjct 1414 A-QLGAEGAGLVAEVGPGVTDLAVGDAVLGILGLTGSEAVVDRRLVTRVPPDWSLAEAAG 1472 Query 1017 VPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTL 1076 VPVVFLTA YGL+ LA ++AGE VL+HA GGVGMAAVQLAR WG EVF TASRGKW+TL Sbjct 1473 VPVVFLTALYGLSVLAGLRAGERVLVHAAAGGVGMAAVQLARHWGAEVFATASRGKWETL 1532 Query 1077 RAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFVDASLRLLVRGGRFLEMG 1136 RAMGFDD HI DSRT EFEEKF A T G GVDVVL+SLAGEF DASLRLL GGRF+EMG Sbjct 1533 RAMGFDDAHIADSRTLEFEEKFSAATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMG 1592 Query 1137 KTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELFDTRELHRLPVTTWDVRC 1196 KTD+RD + GV YRAFDL EAGP R+ EMLAE+ LF L LPV +D+RC Sbjct 1593 KTDLRDPDTLT----GVGYRAFDLMEAGPDRIAEMLAELMRLFAAGVLKPLPVRAFDIRC 1648 Query 1197 APAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAVGGVLARHLVGAYGVRHL 1256 A A+RF+SQARHIGKVVLTM LA GT ++TG TG G +ARHLV Y V H+ Sbjct 1649 AADAYRFVSQARHIGKVVLTM-PGGPAGLAGGTALVTGGTGMAGSAVARHLVERYRVPHV 1707 Query 1257 VLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHA 1316 +L SR G+RA G L L GA+V VVACDV D AVAGL A++ + P+RGV HA Sbjct 1708 MLVSRGGERAAGVPGLVDGLRATGAEVTVVACDVGDPEAVAGLLARVPARF-PLRGVFHA 1766 Query 1317 AGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGSPGQGN 1376 AGVLDDAVI SLTP R+DTVLR+K D AW+LH+ T LDLS F + SS+A VG+PGQGN Sbjct 1767 AGVLDDAVIASLTPQRVDTVLRSKADGAWHLHELTRGLDLSAFVMFSSMAGIVGAPGQGN 1826 Query 1377 YSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAE 1436 Y+AAN+FLDGLAAHR+A GL G+S+AWG+W + MT HL RD ARMSR+GLA +S + Sbjct 1827 YAAANSFLDGLAAHRRAHGLPGLSVAWGMWAEESAMTGHLGERDKARMSRAGLAALSTGQ 1886 Query 1437 AVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSS 1496 A++L DAAL + P+ VAT LD A ALP L S LA RP RR +D T S Sbjct 1887 ALDLLDAALLAEPPVVVATRLDATA--LAHAGAALPPLLSQLAARPARRVLDPTD--MVS 1942 Query 1497 KSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELR 1556 + L RL GLA +++ LV LVC AA VLG +A DVD + F DLGFDSLTAVELR Sbjct 1943 LTGLRARLDGLAPEQRRRELVELVCGNAATVLGHSTA-DVDAEQAFADLGFDSLTAVELR 2001 Query 1557 NRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMS 1590 NRLK ATGLTL PT+IFDHPTP A+AE++ Q++ Sbjct 2002 NRLKIATGLTLSPTLIFDHPTPAALAEHLDGQLA 2035 >gi|342859764|ref|ZP_08716417.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] gi|342132896|gb|EGT86116.1| erythronolide synthase, modules 3 and 4 [Mycobacterium colombiense CECT 3035] Length=4176 Score = 1571 bits (4067), Expect = 0.0, Method: Compositional matrix adjust. Identities = 915/1613 (57%), Positives = 1105/1613 (69%), Gaps = 48/1613 (2%) Query 2 ISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLASRSVFEHRAVVVGASREQLIAGLA 61 +SA+S ALT+QA RL AH++A+P LD DVG SLA RS FE RAVVVG R+ L+AGL Sbjct 2514 VSAKSLSALTSQATRLAAHLRAHPDLDIADVGWSLAGRSAFEQRAVVVGGDRDGLLAGLE 2573 Query 62 GLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRELYGELPVFAQAFDAVADELDR 121 LA G + G + GKT VFPGQG+Q +GMGR L+ PVFA+AFD V ELD+ Sbjct 2574 ELAGDNLGGSIIQGT-ATAGKTAFVFPGQGSQTLGMGRGLHAGYPVFAEAFDTVVAELDQ 2632 Query 122 HLRLPLRDVIWGADADLLDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAA 181 HL PLR+V+WG D LL+STEFAQPALFAVEVA F +L WGV PDFVMGHS+GELAAA Sbjct 2633 HLLRPLREVMWGDDETLLNSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELAAA 2692 Query 182 HAAGVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLL----GEGVGIAAINA 237 H AGVL+L +AA+LV ARGR MQALP GGAMVAV A+EDEV LL VGIAA+N Sbjct 2693 HVAGVLSLQNAAVLVAARGRFMQALPEGGAMVAVQATEDEVRALLVGSDQASVGIAAVNG 2752 Query 238 PESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVAARVQAREP 297 P SVVISGA A A+ADR A G RVH+L+VSHAFHSPLM+PM++EF VAA + +P Sbjct 2753 PTSVVISGAHEAVAAVADRLRADGHRVHRLSVSHAFHSPLMDPMIDEFGTVAAGLTVGKP 2812 Query 298 QLGLVSNVTGELAGPDFGSAQYWVDHVRRPVRFADSARHLQTLGATHFIEAGPGSGLTGS 357 + +VSNVTG+LAG D+ S YW HVR VRFADS R + + GA F+E GPGSGLT S Sbjct 2813 AIPIVSNVTGQLAGDDYASVAYWKRHVREAVRFADSVRFVHSAGANRFLEVGPGSGLTAS 2872 Query 358 IEQSLA--PAEAMVVSM--LGKDRPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQL 413 IE+SLA P A V +M L KDRPE S + A Q + G+ V W G V+L Sbjct 2873 IEESLAADPMAASVTTMSALRKDRPEPLSLVNAVAQGYVAGMDVDWRGALGE--GNLVEL 2930 Query 414 PTYAFQRRRFWETPGADGPADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPW 473 PTYAF RRRFW PADAAGLGL A EHALLGAVVE P S VVLTGRLS Q W Sbjct 2931 PTYAFDRRRFW-LAADGAPADAAGLGLAAGEHALLGAVVELPASGGVVLTGRLSPGTQGW 2989 Query 474 LADHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVGAAD 533 LADH V GVVLFPGAGFVEL IRAGDEVGC ++EEL LAAPLV+ G V VQVVVG D Sbjct 2990 LADHAVGGVVLFPGAGFVELAIRAGDEVGCGVVEELNLAAPLVLPAGGSVAVQVVVGGPD 3049 Query 534 ESGHRAVSVYSRGDQSQGWLLNAEGMLGVAAAETPMDLSVWPPEGAESVDISDGYAQLAE 593 +SG RAVSV+SR + GW L+AEG L + + DLS WPP GA VD+ DGY QLAE Sbjct 3050 DSGSRAVSVFSRAEAGSGWSLHAEGALRAGSVQPSADLSAWPPVGAVPVDVGDGYEQLAE 3109 Query 594 RGYAYGPAFQGLVAIWRRGSELFAEVVAPGEAGVAVDRMGMHPAVLDAVLHALGLAVEKT 653 RGYAYGPAF+GL ++WRRG E+FAEV P +AGV+ G+HPA+LDA LHA+ LA + Sbjct 3110 RGYAYGPAFRGLTSMWRRGDEVFAEVSLPTDAGVSPAGFGVHPAMLDAALHAVMLASDSD 3169 Query 654 QASTETRL-PFCWRGVSLHAGGAGRVRARFASAGADAISVDVCDATGLPVLTVRSLVTRP 712 + + L PF W+ VSLHA GAG VRAR +S+++ D GLPVL+V S+V RP Sbjct 3170 ELPEGSMLVPFSWQQVSLHAAGAGAVRARIVPVSPSTVSIELADGLGLPVLSVASMVARP 3229 Query 713 ITAEQLRAAVTAAGGASDQGP---LEVVWSPISVVSGGANGSAPPAPVSWADFCA----G 765 +T +QL AAV S+ GP EV+WS A SA PVS + + G Sbjct 3230 VTDKQLLAAV------SNSGPDRLFEVIWS--------AQPSAAVQPVSLSAWGTAELDG 3275 Query 766 SDGDASVVVWELESAGGQASSVVGSVYAATHTALEVLQSWLGADRAATLVVLTHGGVGLA 825 + + S V++E + G V+ VYAAT L VLQSWL D AATLVV T G + L Sbjct 3276 TGAERSAVLFESQPVSGD---VITEVYAATRAVLPVLQSWLSRDDAATLVVATRGAMTLP 3332 Query 826 GEDISDLAAAAVWGMARSAQAENPGRIVLIDTDA---AVDASVLAGVGEPQLLVRGGTVH 882 GED++DLA AAVWG+ RSAQ E+PGRIVL+DTDA A + + + EPQ ++R GTV+ Sbjct 3333 GEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDTDAPLDADAVAAVLALAEPQAILRNGTVY 3392 Query 883 APRL--SPAPALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVG 940 R+ S A L LP + WRL GT+E+L I+ P+ APL GQVRVA++A+ Sbjct 3393 TARVLGSRAVGGLLLPPDDGPWRLGMSSYGTIENLRIERIPDADAPLGHGQVRVALSAIA 3452 Query 941 VNFRDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG-FLGGAGPLAVVDQ 999 NFRDV+ ALG+YP +G E +GVV+ET AVGD VMG F G G +A DQ Sbjct 3453 ANFRDVMIALGLYPDPEAIMGIEASGVVIETASPDGRFAVGDRVMGLFPDGTGTIAKTDQ 3512 Query 1000 QLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAGTGGVGMAAVQLARQ 1059 +L+ +VP GWS AA VVF TA Y L DLA K G+ VL+HA GGVGMAAVQLAR Sbjct 3513 RLLVKVPAGWSHTAAATASVVFATANYALVDLAGAKPGQRVLVHAAAGGVGMAAVQLARH 3572 Query 1060 WGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGEFV 1119 G+EVF TASRGKWDTLR MGFDDDHI DSR+ FE+KF AVT GRG+D+VLDSL+G+FV Sbjct 3573 IGLEVFATASRGKWDTLREMGFDDDHIADSRSLGFEDKFRAVTAGRGMDIVLDSLSGDFV 3632 Query 1120 DASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQYRAFDLSEAGPARMQEMLAEVRELF 1179 DASLRL GG FLEMGKTDIRD + +A + GV+YRAFDL EAGP R+ +ML E+ +F Sbjct 3633 DASLRLTAPGGVFLEMGKTDIRDPEVVAREHAGVRYRAFDLFEAGPDRIAQMLDELAAMF 3692 Query 1180 DTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGAV 1239 L LPVT +DVR APAA R++SQARH+GKVV+TMP D GTV+ITGATG Sbjct 3693 GEDVLRPLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITGATGMA 3748 Query 1240 GGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKVQVVACDVADRAAVAGL 1299 G +ARH+V +G R+LVL SRRG A GAAEL A+L+ AGA V+ VACD ADR A+A + Sbjct 3749 GSAVARHVVSRHGARNLVLVSRRGLDAPGAAELVAELSAAGAHVEAVACDAADREALAKV 3808 Query 1300 FAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMF 1359 A++ ++P + GVIHAAGVL DAV+TSLTPDRI++VLR+KVDAAWNLH+ T +LD+S F Sbjct 3809 IAEIPMQHP-LTGVIHAAGVLHDAVVTSLTPDRIESVLRSKVDAAWNLHELTRELDVSAF 3867 Query 1360 ALCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSR 1419 + SSIA G+ GQ NY+A N+FLDGLAAHR+A GL ISL WGLW+Q MT L + Sbjct 3868 VMFSSIAGLAGASGQANYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAA 3927 Query 1420 DLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLA 1479 D AR R G+ MS +A+EL D AL +D P + +D AAL + G LP +F L Sbjct 3928 DRARFGRDGIVAMSSDQALELMDTALIVDEPFMLPAHIDLAALRVKFDGGTLPPMFVDLI 3987 Query 1480 RRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDPD 1539 P RRQ+DD+ A SKSAL QRL GL DEQ +L+ LV A VLG S E + PD Sbjct 3988 NAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAILLDLVRANIATVLGSASPEAIHPD 4047 Query 1540 TEFGDLGFDSLTAVELRNRLKTATGLTLPPTVIFDHPTPTAVAEYVAQQMSGS 1592 F +LGFDSLTAVE+RNRLK ATGL L PT+IFD+P A+A Y+ +++ GS Sbjct 4048 RAFQELGFDSLTAVEMRNRLKAATGLALSPTLIFDYPNSAALAGYMYRELVGS 4100 Lambda K H 0.318 0.133 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 4202540076192 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40