BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv2951c Length=381 Score E Sequences producing significant alignments: (Bits) Value gi|15610088|ref|NP_217467.1| oxidoreductase [Mycobacterium tuber... 767 0.0 gi|15842500|ref|NP_337537.1| N5,N10-methylenetetrahydromethanopt... 766 0.0 gi|340627940|ref|YP_004746392.1| putative oxidoreductase [Mycoba... 763 0.0 gi|308232292|ref|ZP_07415577.2| oxidoreductase [Mycobacterium tu... 717 0.0 gi|240171783|ref|ZP_04750442.1| putative oxidoreductase [Mycobac... 677 0.0 gi|15826962|ref|NP_301225.1| oxidoreductase [Mycobacterium lepra... 672 0.0 gi|560512|gb|AAA50933.1| u0002p [Mycobacterium tuberculosis] 664 0.0 gi|75537753|sp|Q4VHK1.1|PHKR_MYCKA RecName: Full=Phthiodiolone/p... 652 0.0 gi|183981771|ref|YP_001850062.1| ketoreductase [Mycobacterium ma... 647 0.0 gi|145223966|ref|YP_001134644.1| luciferase family protein [Myco... 550 1e-154 gi|254821520|ref|ZP_05226521.1| putative oxidoreductase [Mycobac... 452 4e-125 gi|126438074|ref|YP_001073765.1| luciferase family protein [Myco... 449 3e-124 gi|240169254|ref|ZP_04747913.1| N5,N10-methylenetetrahydromethan... 213 6e-53 gi|336459425|gb|EGO38367.1| flavin-dependent oxidoreductase, met... 211 1e-52 gi|41406157|ref|NP_958993.1| hypothetical protein MAP0059c [Myco... 211 1e-52 gi|254820313|ref|ZP_05225314.1| hypothetical protein MintA_10311... 211 2e-52 gi|118463701|ref|YP_879366.1| hypothetical protein MAV_0066 [Myc... 209 6e-52 gi|145223080|ref|YP_001133758.1| luciferase family protein [Myco... 209 7e-52 gi|254773111|ref|ZP_05214627.1| hypothetical protein MaviaA2_002... 208 1e-51 gi|315443537|ref|YP_004076416.1| flavin-dependent oxidoreductase... 207 2e-51 gi|221632070|ref|YP_002521291.1| N5,N10-methylenetetrahydrometha... 206 4e-51 gi|342860225|ref|ZP_08716877.1| hypothetical protein MCOL_15150 ... 206 6e-51 gi|240168925|ref|ZP_04747584.1| N5,N10-methylenetetrahydromethan... 204 2e-50 gi|296167075|ref|ZP_06849486.1| luciferase family protein [Mycob... 204 2e-50 gi|315445312|ref|YP_004078191.1| flavin-dependent oxidoreductase... 200 3e-49 gi|145224981|ref|YP_001135659.1| luciferase family protein [Myco... 200 3e-49 gi|11499987|ref|NP_071233.1| hypothetical protein AF2411 [Archae... 196 7e-48 gi|108798866|ref|YP_639063.1| luciferase-like protein [Mycobacte... 195 1e-47 gi|126434466|ref|YP_001070157.1| luciferase family protein [Myco... 195 1e-47 gi|317126230|ref|YP_004100342.1| Luciferase-like, subgroup [Intr... 191 1e-46 gi|336255154|ref|YP_004598261.1| 5,10-methylenetetrahydromethano... 137 3e-30 gi|288931564|ref|YP_003435624.1| Luciferase-like, subgroup [Ferr... 134 3e-29 gi|167042605|gb|ABZ07327.1| putative Luciferase-like monooxygena... 129 7e-28 gi|167044276|gb|ABZ08956.1| putative Luciferase-like monooxygena... 125 9e-27 gi|167045692|gb|ABZ10340.1| putative Luciferase-like monooxygena... 125 1e-26 gi|161528617|ref|YP_001582443.1| luciferase family protein [Nitr... 125 2e-26 gi|340345165|ref|ZP_08668297.1| Luciferase family protein [Nitro... 122 7e-26 gi|329765467|ref|ZP_08257043.1| luciferase family protein [Candi... 122 1e-25 gi|292494275|ref|YP_003533418.1| Luciferase-like monooxygenase s... 120 3e-25 gi|288930460|ref|YP_003434520.1| luciferase [Ferroglobus placidu... 119 7e-25 gi|333911162|ref|YP_004484895.1| 5,10-methylenetetrahydromethano... 119 7e-25 gi|288931128|ref|YP_003435188.1| 5,10-methylenetetrahydromethano... 119 8e-25 gi|315425300|dbj|BAJ46967.1| N5,N10-methylenetetrahydromethanopt... 118 1e-24 gi|118575742|ref|YP_875485.1| flavin-dependent oxidoreductase [C... 118 2e-24 gi|116753525|ref|YP_842643.1| methylenetetrahydromethanopterin r... 116 7e-24 gi|289192232|ref|YP_003458173.1| 5,10-methylenetetrahydromethano... 115 2e-23 gi|312136502|ref|YP_004003839.1| methylenetetrahydromethanopteri... 114 4e-23 gi|296108846|ref|YP_003615795.1| 5,10-methylenetetrahydromethano... 114 4e-23 gi|15669729|ref|NP_248542.1| methylenetetrahydromethanopterin re... 113 7e-23 gi|2129143|pir||E64491 N5,N10-methylenetetrahydromethanopterin d... 112 7e-23 >gi|15610088|ref|NP_217467.1| oxidoreductase [Mycobacterium tuberculosis H37Rv] gi|31794127|ref|NP_856620.1| oxidoreductase [Mycobacterium bovis AF2122/97] gi|121638832|ref|YP_979056.1| putative oxidoreductase [Mycobacterium bovis BCG str. Pasteur 1173P2] 57 more sequence titles Length=381 Score = 767 bits (1980), Expect = 0.0, Method: Compositional matrix adjust. Identities = 380/381 (99%), Positives = 381/381 (100%), Gaps = 0/381 (0%) Query 1 VGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 +GGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI Sbjct 1 MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 Query 61 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR 120 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR Sbjct 61 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR 120 Query 121 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD 180 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD Sbjct 121 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD 180 Query 181 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP Sbjct 181 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 Query 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI 300 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI Sbjct 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI 300 Query 301 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS 360 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS Sbjct 301 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS 360 Query 361 LRKTVTAVLPHAKVLRGLKKL 381 LRKTVTAVLPHAKVLRGLKKL Sbjct 361 LRKTVTAVLPHAKVLRGLKKL 381 >gi|15842500|ref|NP_337537.1| N5,N10-methylenetetrahydromethanopterin reductase-related protein [Mycobacterium tuberculosis CDC1551] gi|13882808|gb|AAK47351.1| N5,N10-methylenetetrahydromethanopterin reductase-related protein [Mycobacterium tuberculosis CDC1551] gi|323718423|gb|EGB27596.1| oxidoreductase [Mycobacterium tuberculosis CDC1551A] Length=381 Score = 766 bits (1978), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/381 (99%), Positives = 381/381 (100%), Gaps = 0/381 (0%) Query 1 VGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 +GGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI Sbjct 1 MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 Query 61 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR 120 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR Sbjct 61 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR 120 Query 121 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD 180 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD Sbjct 121 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD 180 Query 181 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 LPPYRGKWPEIWV+AHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP Sbjct 181 LPPYRGKWPEIWVSAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 Query 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI 300 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI Sbjct 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI 300 Query 301 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS 360 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS Sbjct 301 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS 360 Query 361 LRKTVTAVLPHAKVLRGLKKL 381 LRKTVTAVLPHAKVLRGLKKL Sbjct 361 LRKTVTAVLPHAKVLRGLKKL 381 >gi|340627940|ref|YP_004746392.1| putative oxidoreductase [Mycobacterium canettii CIPT 140010059] gi|340006130|emb|CCC45302.1| putative oxidoreductase [Mycobacterium canettii CIPT 140010059] Length=381 Score = 763 bits (1971), Expect = 0.0, Method: Compositional matrix adjust. Identities = 378/381 (99%), Positives = 380/381 (99%), Gaps = 0/381 (0%) Query 1 VGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 +GGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI Sbjct 1 MGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 Query 61 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGR 120 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATL LLTRGR Sbjct 61 AAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLQLLTRGR 120 Query 121 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFD 180 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGEL+SRESPYFPLHNALFD Sbjct 121 AILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELVSRESPYFPLHNALFD 180 Query 181 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP Sbjct 181 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 Query 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI 300 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI Sbjct 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDI 300 Query 301 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS 360 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS Sbjct 301 IPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPS 360 Query 361 LRKTVTAVLPHAKVLRGLKKL 381 LRKTVTAVLPHAKVLRGLKKL Sbjct 361 LRKTVTAVLPHAKVLRGLKKL 381 >gi|308232292|ref|ZP_07415577.2| oxidoreductase [Mycobacterium tuberculosis SUMu001] gi|308369912|ref|ZP_07419488.2| oxidoreductase [Mycobacterium tuberculosis SUMu002] gi|308371184|ref|ZP_07424111.2| oxidoreductase [Mycobacterium tuberculosis SUMu003] 19 more sequence titles Length=355 Score = 717 bits (1852), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/355 (100%), Positives = 355/355 (100%), Gaps = 0/355 (0%) Query 27 MAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLP 86 MAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLP Sbjct 1 MAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLP 60 Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR Sbjct 61 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 120 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR Sbjct 121 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 180 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 266 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES Sbjct 181 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 240 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 326 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV Sbjct 241 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 300 Query 327 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL 381 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL Sbjct 301 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL 355 >gi|240171783|ref|ZP_04750442.1| putative oxidoreductase [Mycobacterium kansasii ATCC 12478] Length=391 Score = 677 bits (1747), Expect = 0.0, Method: Compositional matrix adjust. Identities = 327/380 (87%), Positives = 351/380 (93%), Gaps = 0/380 (0%) Query 2 GGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIA 61 GG RFGFVD+LVHSR P ARSSM AAT+ GADSYWVGDHLN LVPRSIAT EYLGIA Sbjct 4 GGFRFGFVDSLVHSRFRPGWLARSSMVAATLTGADSYWVGDHLNGLVPRSIATPEYLGIA 63 Query 62 AKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRA 121 AK VP +DANYEPWTMLGNLA+G P RLRLG+CVTDAGRRNPAVTAQAAATL LLTRG A Sbjct 64 AKLVPSVDANYEPWTMLGNLAYGRPKRLRLGICVTDAGRRNPAVTAQAAATLQLLTRGNA 123 Query 122 ILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDL 181 ILGIGVGEREGNEPYGVEWT+PVARFEEALATIRALWNSNGEL+SRES YFPL NA F+L Sbjct 124 ILGIGVGEREGNEPYGVEWTRPVARFEEALATIRALWNSNGELVSRESAYFPLQNAAFEL 183 Query 182 PPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPM 241 PPYRGKWPEIWVAAHGPRMLRATGRYADAW+PIV+VRP DYS ALEAVR+AASDAGRDPM Sbjct 184 PPYRGKWPEIWVAAHGPRMLRATGRYADAWVPIVLVRPGDYSTALEAVRTAASDAGRDPM 243 Query 242 SITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDII 301 SI P+AVRG+ITGR+RDDVEEAL+SVVVKMTALGVPG AWARHGVEHPMGADF+GVQD+I Sbjct 244 SIIPSAVRGVITGRDRDDVEEALDSVVVKMTALGVPGTAWARHGVEHPMGADFAGVQDVI 303 Query 302 PQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSL 361 PQTMD+QTVLSY AKVP ALMKEVVFSGTP+EV+DQVA+WRDHGL Y+++INGSLVNPSL Sbjct 304 PQTMDEQTVLSYTAKVPPALMKEVVFSGTPEEVVDQVAQWRDHGLEYLLVINGSLVNPSL 363 Query 362 RKTVTAVLPHAKVLRGLKKL 381 RK V A LPHAKVLRGLKKL Sbjct 364 RKAVAASLPHAKVLRGLKKL 383 >gi|15826962|ref|NP_301225.1| oxidoreductase [Mycobacterium leprae TN] gi|221229440|ref|YP_002502856.1| putative oxidoreductase [Mycobacterium leprae Br4923] gi|81621533|sp|Q9CD85.1|PHKR_MYCLE RecName: Full=Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase gi|13092509|emb|CAC29639.1| putative oxidoreductase [Mycobacterium leprae] gi|219932547|emb|CAR70224.1| putative oxidoreductase [Mycobacterium leprae Br4923] Length=382 Score = 672 bits (1733), Expect = 0.0, Method: Compositional matrix adjust. Identities = 324/382 (85%), Positives = 362/382 (95%), Gaps = 1/382 (0%) Query 1 VGGLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGI 60 + G RFGFVDALVH+ PP+LPAR+S+ + V+GADSYWVGDHLNALVPRS+AT +YLG+ Sbjct 1 MAGFRFGFVDALVHTLFPPSLPARASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGV 60 Query 61 AAKFVPKIDANYEPWTMLGNLAFG-LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG 119 AAK VPKIDANYEPWTMLGNLA G + LRLGVCVTDAGRRNPAVTAQAAATLHLLTRG Sbjct 61 AAKVVPKIDANYEPWTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG 120 Query 120 RAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALF 179 +A+LGIGVGEREGNEPYGVEWTKPVARF+EALATIRALW+SNGEL+SRES +FPLHNALF Sbjct 121 KAMLGIGVGEREGNEPYGVEWTKPVARFQEALATIRALWDSNGELVSRESQFFPLHNALF 180 Query 180 DLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRD 239 DLPPYRGKWPEIWVAAHGPRML+ATGRYADAWIPIV+VRP+DYS ALE VR+AASDAGRD Sbjct 181 DLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTDYSCALEVVRTAASDAGRD 240 Query 240 PMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQD 299 PMSITPAAVRGIITGR RDDV+EAL+SV+V+M ALGVPGEAWARHGVEHPMGADF+GVQD Sbjct 241 PMSITPAAVRGIITGRTRDDVDEALDSVLVRMIALGVPGEAWARHGVEHPMGADFAGVQD 300 Query 300 IIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNP 359 IIPQT+D++TV+SYAAKVPAALMKEV+FSGTP+EVIDQVAEWRDHGL+Y+V+INGSLVN Sbjct 301 IIPQTIDEETVVSYAAKVPAALMKEVLFSGTPEEVIDQVAEWRDHGLKYLVVINGSLVNS 360 Query 360 SLRKTVTAVLPHAKVLRGLKKL 381 SLRKTV+A+LPHA+VLRGLKKL Sbjct 361 SLRKTVSALLPHARVLRGLKKL 382 >gi|560512|gb|AAA50933.1| u0002p [Mycobacterium tuberculosis] Length=332 Score = 664 bits (1713), Expect = 0.0, Method: Compositional matrix adjust. Identities = 331/334 (99%), Positives = 332/334 (99%), Gaps = 2/334 (0%) Query 48 VPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTA 107 +PRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTA Sbjct 1 MPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTA 60 Query 108 QAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISR 167 QAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISR Sbjct 61 QAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISR 120 Query 168 ESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALE 227 ESPYFPLHNALFDLPPYRGKWPEIWVA GPRMLRATGRYADAWIPIVVVRPSDYSRALE Sbjct 121 ESPYFPLHNALFDLPPYRGKWPEIWVA--GPRMLRATGRYADAWIPIVVVRPSDYSRALE 178 Query 228 AVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVE 287 AVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVE Sbjct 179 AVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVE 238 Query 288 HPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLR 347 HPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLR Sbjct 239 HPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLR 298 Query 348 YVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL 381 YVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL Sbjct 299 YVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKKL 332 >gi|75537753|sp|Q4VHK1.1|PHKR_MYCKA RecName: Full=Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase gi|62752061|gb|AAX98285.1| phthiodiolone ketoreductase [Mycobacterium kansasii ATCC 12478] Length=367 Score = 652 bits (1682), Expect = 0.0, Method: Compositional matrix adjust. Identities = 316/367 (87%), Positives = 339/367 (93%), Gaps = 0/367 (0%) Query 15 SRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEP 74 SR P ARSSM AAT+ GADSYWVGDHLN LVPRSIAT EYLGIAAK VP +DANYEP Sbjct 1 SRFRPGWLARSSMVAATLTGADSYWVGDHLNGLVPRSIATPEYLGIAAKLVPSVDANYEP 60 Query 75 WTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNE 134 WTMLGNLA+G P RLRLG+CVTDAGRRNPAVTAQAAATL LLTRG AILGIGVGEREGNE Sbjct 61 WTMLGNLAYGRPKRLRLGICVTDAGRRNPAVTAQAAATLQLLTRGNAILGIGVGEREGNE 120 Query 135 PYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVA 194 PYGVEWT+PVARFEEALATIRALWNSNGEL+SRES YFPL NA F+LPPYRGKWPEIWVA Sbjct 121 PYGVEWTRPVARFEEALATIRALWNSNGELVSRESAYFPLQNAAFELPPYRGKWPEIWVA 180 Query 195 AHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITG 254 AHGPRMLRATGRYADAW+PIV+VRP DYS ALEAVR+AASDAGRDPMSI P+AVRG+ITG Sbjct 181 AHGPRMLRATGRYADAWVPIVLVRPGDYSTALEAVRTAASDAGRDPMSIIPSAVRGVITG 240 Query 255 RNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYA 314 R+RDDVEEAL+SVVVKMTALGVPG AWARHGVEHPMGADF+GVQD+IPQTMD+QTVLSY Sbjct 241 RDRDDVEEALDSVVVKMTALGVPGTAWARHGVEHPMGADFAGVQDVIPQTMDEQTVLSYT 300 Query 315 AKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKV 374 AKVP ALMKEVVFSGTP+EV+DQVA+WRDHGL Y+++INGSLVNPSLRK V A LPHAKV Sbjct 301 AKVPPALMKEVVFSGTPEEVVDQVAQWRDHGLEYLLVINGSLVNPSLRKAVAASLPHAKV 360 Query 375 LRGLKKL 381 LRGLKKL Sbjct 361 LRGLKKL 367 >gi|183981771|ref|YP_001850062.1| ketoreductase [Mycobacterium marinum M] gi|183175097|gb|ACC40207.1| ketoreductase [Mycobacterium marinum M] Length=385 Score = 647 bits (1668), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/380 (84%), Positives = 356/380 (94%), Gaps = 1/380 (0%) Query 3 GLRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAA 62 G R+GFVDA VHSRLPP++ ARSSM A VMGADSYW+GDHLNALVPRS+AT E+LG+ A Sbjct 6 GFRYGFVDAPVHSRLPPSMIARSSMMAGAVMGADSYWIGDHLNALVPRSVATPEFLGLGA 65 Query 63 KFVPKIDANYEPWTMLGNLAFG-LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRA 121 + VPK+DANYEPWTMLGNLA G +RLRLGVCVTD GRRNPAVTAQAAAT+HLLTRGRA Sbjct 66 RLVPKVDANYEPWTMLGNLAAGNRINRLRLGVCVTDVGRRNPAVTAQAAATVHLLTRGRA 125 Query 122 ILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDL 181 ILGIGVGEREGNEPYGVEW+KPVARFEE LATIRALW+SNG L++RESPYFPL NALFDL Sbjct 126 ILGIGVGEREGNEPYGVEWSKPVARFEEGLATIRALWDSNGALVTRESPYFPLRNALFDL 185 Query 182 PPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPM 241 PPY+GKWPEIWVAAHGPRMLRATGRYADAW+PIV++RP+DYSRALEAVR+AASDAGRDPM Sbjct 186 PPYKGKWPEIWVAAHGPRMLRATGRYADAWVPIVIIRPTDYSRALEAVRAAASDAGRDPM 245 Query 242 SITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDII 301 SITP+AVRG++TG +RDDV+EAL+SV+VKM ALG+P EAWARHGVEHPMGADF+GVQD+I Sbjct 246 SITPSAVRGVVTGWSRDDVDEALDSVIVKMNALGMPAEAWARHGVEHPMGADFTGVQDLI 305 Query 302 PQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSL 361 PQTMD++TVLSY AKVP L++EVV SGTPDEVIDQVAEWRDHGLRY+++INGSLVNPSL Sbjct 306 PQTMDRETVLSYTAKVPPGLIREVVASGTPDEVIDQVAEWRDHGLRYLLVINGSLVNPSL 365 Query 362 RKTVTAVLPHAKVLRGLKKL 381 RKTVTAVLPHAKVLRGLKKL Sbjct 366 RKTVTAVLPHAKVLRGLKKL 385 >gi|145223966|ref|YP_001134644.1| luciferase family protein [Mycobacterium gilvum PYR-GCK] gi|315444298|ref|YP_004077177.1| flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase [Mycobacterium sp. Spyr1] gi|145216452|gb|ABP45856.1| luciferase family protein [Mycobacterium gilvum PYR-GCK] gi|315262601|gb|ADT99342.1| flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase [Mycobacterium sp. Spyr1] Length=389 Score = 550 bits (1417), Expect = 1e-154, Method: Compositional matrix adjust. Identities = 269/378 (72%), Positives = 321/378 (85%), Gaps = 0/378 (0%) Query 4 LRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAK 63 RFG +D +V++R+ PTL ++M A+ GADS+WVGDH+N+LVPRS+AT E+LG+AAK Sbjct 12 FRFGLLDGIVNTRVSPTLLPSAAMLTASATGADSFWVGDHINSLVPRSVATPEHLGLAAK 71 Query 64 FVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAIL 123 VPK+DA EPWTMLG+LA RLR GV VTDA RR+PAVTAQAAATLHLLTRGRAIL Sbjct 72 LVPKVDAILEPWTMLGHLAARHRGRLRFGVGVTDASRRHPAVTAQAAATLHLLTRGRAIL 131 Query 124 GIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDLPP 183 GIGVGEREGNEPYGVEWTKPVARF EALATIRALW S GE ++RES YFPL +A+FDLPP Sbjct 132 GIGVGEREGNEPYGVEWTKPVARFVEALATIRALWESGGEPVTRESDYFPLRHAVFDLPP 191 Query 184 YRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSI 243 Y+G+WPEIWVAAHGPRMLRATGRYAD W+P V+ RP+DY+RAL+AVR+AASD GRDPM+I Sbjct 192 YKGRWPEIWVAAHGPRMLRATGRYADGWVPFVISRPADYARALDAVRTAASDNGRDPMAI 251 Query 244 TPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQ 303 PA R ++TGR R DV+EAL+SV+VK AL P EAWARHGVEHP+G+DFSGVQD++PQ Sbjct 252 VPAVNRTVVTGRTRADVDEALDSVIVKSVALAAPAEAWARHGVEHPLGSDFSGVQDLVPQ 311 Query 304 TMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRK 363 +DK+ L+Y A VPA+LMKE+ F GT DEV+DQVAEWRDHGLRY+++INGS +NP LRK Sbjct 312 MIDKEAALAYTASVPASLMKEICFHGTADEVLDQVAEWRDHGLRYLLVINGSQLNPKLRK 371 Query 364 TVTAVLPHAKVLRGLKKL 381 V+A LP+ +VLRGLKKL Sbjct 372 GVSATLPYNRVLRGLKKL 389 >gi|254821520|ref|ZP_05226521.1| putative oxidoreductase [Mycobacterium intracellulare ATCC 13950] Length=378 Score = 452 bits (1163), Expect = 4e-125, Method: Compositional matrix adjust. Identities = 219/382 (58%), Positives = 280/382 (74%), Gaps = 8/382 (2%) Query 4 LRFGFVDALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAK 63 ++FG V+A +HSR PT A A + GADSYW+ DHLNA +PR++ T +Y GIA + Sbjct 1 MKFGVVEAPLHSRFGPTAAAEMGYRVAMLTGADSYWLPDHLNAFLPRAVMTPKYSGIA-R 59 Query 64 FVPKIDANYEPWTMLGNLA----FGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRG 119 P DA EPWT LG+LA F +R+RLG CVTD GRRNPAVTAQAAATLHL+TRG Sbjct 60 LAPDADAFLEPWTTLGHLAGRHRF---NRMRLGTCVTDTGRRNPAVTAQAAATLHLMTRG 116 Query 120 RAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALF 179 RA+LGIG GEREGNEPYGV+W+KPVARFEE LATIRALWNSNG+L++R+S +FPL NA+F Sbjct 117 RAVLGIGTGEREGNEPYGVDWSKPVARFEEGLATIRALWNSNGQLVNRDSEWFPLRNAIF 176 Query 180 DLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRD 239 LP +G P+IWVA+HGPRMLRATGRYAD W P+ +V P Y+ LE VR+AA DA RD Sbjct 177 TLPAVKGNRPQIWVASHGPRMLRATGRYADGWFPVAIVSPERYATGLEQVRAAADDANRD 236 Query 240 PMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQD 299 P SI A + ++TGR+ +V++ALESV + AL +P WA HG HPMG +G QD Sbjct 237 PYSIVAAITQFVVTGRSTAEVDDALESVPARTYALLLPDVEWAEHGARHPMGEGCTGYQD 296 Query 300 IIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNP 359 I+PQ +D+ T L++ VP ALM+ + SGTPDEV+DQ+A +RDHG+RY L+N S + P Sbjct 297 ILPQLLDEATTLAHIDAVPRALMRRCLLSGTPDEVLDQLATYRDHGVRYPTLLNMSTIQP 356 Query 360 SLRKTVTAVLPHAKVLRGLKKL 381 L + +++ LP K+LRG+ +L Sbjct 357 QLSRGLSSALPFMKILRGIARL 378 >gi|126438074|ref|YP_001073765.1| luciferase family protein [Mycobacterium sp. JLS] gi|160417592|sp|A3Q7Z7.1|PHKR_MYCSJ RecName: Full=Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase gi|126237874|gb|ABO01275.1| luciferase family protein [Mycobacterium sp. JLS] Length=380 Score = 449 bits (1156), Expect = 3e-124, Method: Compositional matrix adjust. Identities = 225/385 (59%), Positives = 283/385 (74%), Gaps = 13/385 (3%) Query 3 GLRFGFVDALVHSRLPPTLPARSSMAAATVMGA-----DSYWVGDHLNALVPRSIATSEY 57 G R G D + P PA +M A +GA DS+WV DHLN L PRS+ +Y Sbjct 3 GFRVGVGDGI-----PAARPAAETMTRANYLGAVANRVDSFWVPDHLNQLFPRSLWKQKY 57 Query 58 LGIAAKFVPKIDANYEPWTMLGNLAF-GLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLL 116 G A K +P++DA EPWTMLG++A RLRLGV VTD+GRRNPAVTAQAAATLHLL Sbjct 58 CG-ATKLIPRVDAVMEPWTMLGHIAARNRAGRLRLGVAVTDSGRRNPAVTAQAAATLHLL 116 Query 117 TRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHN 176 TRGRAILGIG GEREGNEPYGV+W+KPVARFEEA+ATIRALW+S GEL++R+SP+FPL Sbjct 117 TRGRAILGIGPGEREGNEPYGVDWSKPVARFEEAMATIRALWDSGGELVNRDSPFFPLRK 176 Query 177 ALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDA 236 A+FDLPPYRGKWPEIW+AAHGPRMLRA GRYADA+ P P++Y++ L++VRSAASD Sbjct 177 AIFDLPPYRGKWPEIWIAAHGPRMLRAAGRYADAYFPSFAHLPTEYAQRLDSVRSAASDV 236 Query 237 GRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSG 296 GRDPM+I PA ++TG RDDV+EAL+S +++ L + + RHG HPMGA FSG Sbjct 237 GRDPMAILPAVQMFVVTGSTRDDVDEALDSELLRAFGLNASDDVFTRHGGRHPMGAGFSG 296 Query 297 VQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSL 356 QD++P MD+QT LS+ A +P + +E + +GT DEVI Q A+WRD +RY+VL+N S Sbjct 297 AQDLLPHDMDEQTALSHVAVIPPGVTREFLLNGTSDEVIQQAAQWRD-CVRYMVLVNVSF 355 Query 357 VNPSLRKTVTAVLPHAKVLRGLKKL 381 + +LRK + +V P K++R LKKL Sbjct 356 LQRNLRKGLMSVKPFNKIVRELKKL 380 >gi|240169254|ref|ZP_04747913.1| N5,N10-methylenetetrahydromethanopterin reductase-related protein [Mycobacterium kansasii ATCC 12478] Length=351 Score = 213 bits (541), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 131/320 (41%), Positives = 180/320 (57%), Gaps = 4/320 (1%) Query 33 MGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLG 92 M DS + DH + PR+I E +AA+ P ++ +LG LA R+RLG Sbjct 1 MRLDSVMLIDHFQNVFPRAIWDRELTWLAARR-PTPHEFFDYQVLLGYLA-SRAGRMRLG 58 Query 93 VCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALA 152 V VT++ RR+P + AQA TL LT+ ILGIG GER +PYG++ PVAR EEAL Sbjct 59 VGVTESIRRHPVLIAQAMVTLSHLTKRAPILGIGAGERMNIDPYGLDSAHPVARLEEALQ 118 Query 153 TIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWI 212 IR ++ G I+ YF L A DL P G+ PEIW+A HGPRML TGRY D W Sbjct 119 IIRLCLSARGP-ITFCGEYFRLDRATVDLKPAAGRVPEIWIAGHGPRMLALTGRYGDGWY 177 Query 213 PIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMT 272 P VV P +Y+ L VR+AA AGR+P +TPA R + + L + V++ Sbjct 178 PTAVVSPREYADKLTTVRAAARAAGRNPAEVTPALHRFTVIAATECEARAMLRTKVIRAL 237 Query 273 ALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKE-VVFSGTP 331 L P E W + G+ HP+G F+ + D +P D+ T+ A VP L+ E + G+P Sbjct 238 GLMTPAELWRQAGLVHPLGEHFNPLVDFVPDHYDRATMDDAIAAVPEELVAEGPLLWGSP 297 Query 332 DEVIDQVAEWRDHGLRYVVL 351 D+V+ ++ E+ D GLR+VVL Sbjct 298 DQVVSRLREFGDAGLRHVVL 317 >gi|336459425|gb|EGO38367.1| flavin-dependent oxidoreductase, methylene-tetrahydromethanopterin reductase [Mycobacterium avium subsp. paratuberculosis S397] Length=375 Score = 211 bits (538), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 124/322 (39%), Positives = 174/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI E+ +A A+ P L LA L R L Sbjct 30 SVWLPDHMVSFWPDSIWAPEFTDLAT-------ASPSPHRHLDGLAVAAAVAVLTERAPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA+ AQ A TL L++GR ILG+G GE E PYG ++ +PV+RFEEAL Sbjct 83 VSAVVDTVRRHPALLAQTALTLDHLSKGRFILGLGSGESENTVPYGFDFARPVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+++G + + ++ LH A D PY G+ P IW+ A GPRML GRYAD W Sbjct 143 RVIRLLWDTDGP-VDFDGEFYSLHQARLDTEPYHGRLPPIWIGASGPRMLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y++ L AVR +A AGRDPM+ITP ++ + G + D + E L + +VK Sbjct 202 WPAGAWTPEHYAQMLGAVRVSAERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G EHPMG + G QDI P + + ++ + +V ++ VV GTP Sbjct 262 FLLQVSAKTLGEFGFEHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLAVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V + D GLR +++ Sbjct 322 KQVAKIVKSYVDAGLRVPKILD 343 >gi|41406157|ref|NP_958993.1| hypothetical protein MAP0059c [Mycobacterium avium subsp. paratuberculosis K-10] gi|41394505|gb|AAS02376.1| hypothetical protein MAP_0059c [Mycobacterium avium subsp. paratuberculosis K-10] Length=375 Score = 211 bits (538), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 124/322 (39%), Positives = 174/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI E+ +A A+ P L LA L R L Sbjct 30 SVWLPDHMVSFWPDSIWAPEFTDLAT-------ASPSPHRHLDGLAVAAAVAVLTERAPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA+ AQ A TL L++GR ILG+G GE E PYG ++ +PV+RFEEAL Sbjct 83 VSAVVDTVRRHPALLAQTALTLDHLSKGRFILGLGSGESENTVPYGFDFARPVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+++G + + ++ LH A D PY G+ P IW+ A GPRML GRYAD W Sbjct 143 RVIRLLWDTDGP-VDFDGEFYSLHQARLDTEPYHGRLPPIWIGASGPRMLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y++ L AVR +A AGRDPM+ITP ++ + G + D + E L + +VK Sbjct 202 WPAGAWTPEHYAQMLGAVRVSAERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G EHPMG + G QDI P + + ++ + +V ++ VV GTP Sbjct 262 FLLQVSAKTLGEFGFEHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLAVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V + D GLR +++ Sbjct 322 KQVAKIVKSYVDAGLRVPKILD 343 >gi|254820313|ref|ZP_05225314.1| hypothetical protein MintA_10311 [Mycobacterium intracellulare ATCC 13950] Length=375 Score = 211 bits (537), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 123/322 (39%), Positives = 177/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A A+ P L LA L R+ + Sbjct 30 SIWLPDHMVSFWPDSIWTPEFTDLAT-------ASPSPHRHLDGLAVAAAAAVLTERVPI 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+P + AQ A T+ L +GR ILG+G GE E PYG ++++PV+RFEEAL Sbjct 83 VSAVVDTVRRHPVMLAQTALTIDHLAKGRFILGLGSGESENTLPYGFDFSRPVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW S+G + + ++ LH+A D PY G+ P+IW+ A GPRML GR+AD W Sbjct 143 TVIRLLWRSDGP-VDFDGQFYSLHHARLDTEPYEGRPPQIWIGASGPRMLDIAGRHADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y+ L AVR++A AGRDPM+ITP+ ++ + G + + E L++ +VK Sbjct 202 WPAGAWTPGHYAEMLTAVRTSAERAGRDPMAITPSFIQVCLIGEDDAALAEILQAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G EHPMG + G QDI P + + ++ + KV ++ VV GTP Sbjct 262 FLLQVSAKTLRDFGFEHPMGDGWRGFQDIDPAVLTRDRIVEFLGKVRPEMVLSVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 EV V + D GLR +++ Sbjct 322 KEVARIVKTYVDAGLRVPKILD 343 >gi|118463701|ref|YP_879366.1| hypothetical protein MAV_0066 [Mycobacterium avium 104] gi|118164988|gb|ABK65885.1| conserved hypothetical protein [Mycobacterium avium 104] Length=375 Score = 209 bits (532), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 123/322 (39%), Positives = 172/322 (54%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI E+ +A A+ P L LA L R+ L Sbjct 30 SVWLPDHMVSFWPDSIWAPEFTDLAT-------ASASPHRHLDGLAVAAAAAVLTERVPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA+ AQ A TL L++GR ILG+G GE E PYG ++ +PV+RFEEAL Sbjct 83 VSAVVDTVRRHPALLAQTALTLDHLSKGRFILGLGSGESENTVPYGFDFARPVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+++G + ++ LH A D PY + P IW+ A GPRML GRYAD W Sbjct 143 RVIRLLWDTDGP-VDFNGEFYSLHQARLDTEPYHDRLPPIWIGASGPRMLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y+ L AVR +A AGRDPM+ITP ++ + G + D + E L + +VK Sbjct 202 WPAGAWTPEHYAEMLGAVRVSAERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G EHPMG + G QDI P + + ++ + +V ++ VV GTP Sbjct 262 FLLQVSAKTLGEFGFEHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLAVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V + D GLR +++ Sbjct 322 KQVAKIVKSYVDAGLRVPKILD 343 >gi|145223080|ref|YP_001133758.1| luciferase family protein [Mycobacterium gilvum PYR-GCK] gi|145215566|gb|ABP44970.1| luciferase family protein [Mycobacterium gilvum PYR-GCK] Length=372 Score = 209 bits (532), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 122/322 (38%), Positives = 175/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A A+ P L +A L + L Sbjct 30 SIWLPDHMVSFWPDSIWTPEFTDLAV-------ASPSPHRHLDGMAVAAAAAVLTENVPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA AQ+A T+ L++GR ILG+G GERE PYG ++ PV RFEEAL Sbjct 83 ATSVVDTVRRHPASLAQSALTIDHLSKGRFILGLGSGERENILPYGFDFRSPVGRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW++ G + + ++ L +A D PY G+ P IWV A GPR L GRYAD W Sbjct 143 HVIRLLWDTEGP-VDFDGRFYRLRHARLDTEPYEGRRPPIWVGASGPRSLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P DY+ L VRS+A AGRDP ITP ++ + GR+ + E L++ +VK Sbjct 202 WPAGAWTPDDYAEKLTRVRSSAERAGRDPQQITPCFIQVCLMGRDDAALAEILQAPLVKS 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V E R G EHPMG D++G DI P + ++ ++ + +V ++ +V GTP Sbjct 262 FLLQVSAEVLRRFGFEHPMGPDWNGFHDIDPAVLTRERIVEFLDRVQPEMVLAMVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V + ++ D GLR +++ Sbjct 322 KQVARVIKDYVDVGLRVPKILD 343 >gi|254773111|ref|ZP_05214627.1| hypothetical protein MaviaA2_00296 [Mycobacterium avium subsp. avium ATCC 25291] Length=375 Score = 208 bits (529), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 122/322 (38%), Positives = 172/322 (54%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI E+ +A A+ P L LA L R+ L Sbjct 30 SVWLPDHMVSFWPDSIWAPEFTDLAT-------ASASPHRHLDGLAVAAAAAVLTERVPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA+ AQ A TL L++GR ILG+G GE E PYG ++ +PV+RFEEAL Sbjct 83 VSAVVDTVRRHPALLAQTALTLDHLSKGRFILGLGSGESENTVPYGFDFARPVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+++G + ++ LH A D PY + P IW+ A GPRML GRYAD W Sbjct 143 RVIRLLWDTDGP-VDFNGEFYSLHQARLDTEPYHDRLPPIWIGASGPRMLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y+ L AVR +A AGRDPM+ITP ++ + G + D + E L + +VK Sbjct 202 WPAGAWTPEHYAEMLGAVRVSAERAGRDPMAITPCFIQVCLIGEDDDALAEILRAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G +HPMG + G QDI P + + ++ + +V ++ VV GTP Sbjct 262 FLLQVSAKTLGEFGFDHPMGDGWRGFQDIDPAALGRDRIVEFLHRVRPEMVLAVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V + D GLR +++ Sbjct 322 KQVAKIVKSYVDAGLRVPKILD 343 >gi|315443537|ref|YP_004076416.1| flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase [Mycobacterium sp. Spyr1] gi|315261840|gb|ADT98581.1| flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase [Mycobacterium sp. Spyr1] Length=372 Score = 207 bits (527), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 121/322 (38%), Positives = 174/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A A+ P L +A L + L Sbjct 30 SIWLPDHMVSFWPDSIWTPEFTDLAV-------ASPSPHRHLDGMAVAAAAAVLTENVPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA AQ+A T+ L++GR ILG+G GERE PYG ++ PV RFEEAL Sbjct 83 ATSVVDTVRRHPASLAQSALTIDHLSKGRFILGLGSGERENILPYGFDFRSPVGRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW++ G + + ++ L +A D PY G+ P IWV A GPR L GRYAD W Sbjct 143 HVIRLLWDTEGP-VDFDGRFYRLRHARLDTEPYEGRRPPIWVGASGPRSLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P DY+ L VRS+A A RDP ITP ++ + GR+ + E L++ +VK Sbjct 202 WPAGAWTPDDYAEKLTRVRSSAERADRDPQQITPCFIQVCLMGRDDAALAEILQAPLVKS 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V E R G EHPMG D++G DI P + ++ ++ + +V ++ +V GTP Sbjct 262 FLLQVSAEVLQRFGFEHPMGPDWNGFHDIDPAVLTRERIVEFLDRVQPEMVLAMVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V + ++ D GLR +++ Sbjct 322 KQVARVIKDYVDAGLRVPKILD 343 >gi|221632070|ref|YP_002521291.1| N5,N10-methylenetetrahydromethanopterin reductase-like protein [Thermomicrobium roseum DSM 5159] gi|221155347|gb|ACM04474.1| N5,N10-methylenetetrahydromethanopterin reductase-related protein [Thermomicrobium roseum DSM 5159] Length=379 Score = 206 bits (525), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 132/354 (38%), Positives = 189/354 (54%), Gaps = 8/354 (2%) Query 11 ALVHSRLPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDA 70 ALV PP + A ++ D+ V DHL VPR + + IA + Sbjct 9 ALVVPAQPPLASVLGLVRLARLLRFDAVMVWDHLQDFVPRVLWSPRTTWIA-RLRRSPHP 67 Query 71 NYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGER 130 Y+ ++LG L+ RLRLGV VTD RR+P + AQ A TL LTR I+GIG GE Sbjct 68 YYDFASLLGRLS-AHAGRLRLGVGVTDPIRRHPVLLAQTALTLAHLTRRPPIIGIGAGEA 126 Query 131 EGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDL--PPYRGKW 188 E EPYG + +PV R EEALA +RA ++ G I ++ + + +F+L PP R Sbjct 127 ENLEPYGFPFDRPVTRLEEALAILRACLDTPGT-IRFAGRFYQITDGVFELTAPPRRR-- 183 Query 189 PEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAV 248 PEIW+ AHGPRML TGR+AD W P + P Y+ L VR AA AGRDP I PA Sbjct 184 PEIWLGAHGPRMLELTGRFADGWYPNWIDSPERYAARLAQVRQAAERAGRDPTQIVPALQ 243 Query 249 RGIITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQ 308 ++ + L +++T L P + W G+EHP+G F G D IP+ +D Sbjct 244 APVLLAPTENAARRLLHHPALRLTGLLRPADEWRELGLEHPLGEHFRGYLDFIPERVDPH 303 Query 309 TVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGS-LVNPSL 361 + + VP L++ GTP++V+ ++ ++R+ GLR++ L+ S L +P + Sbjct 304 ALRAALRAVPPELVERSFLWGTPEQVLARIRDYREAGLRFLGLLPVSALASPQV 357 >gi|342860225|ref|ZP_08716877.1| hypothetical protein MCOL_15150 [Mycobacterium colombiense CECT 3035] gi|342132603|gb|EGT85832.1| hypothetical protein MCOL_15150 [Mycobacterium colombiense CECT 3035] Length=375 Score = 206 bits (524), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 121/322 (38%), Positives = 175/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A A+ P L LA L R+ L Sbjct 30 SLWLPDHMVSFWPDSIWTPEFTDLAT-------ASPSPHRHLDGLAVAAAAAVLTERVPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA+ AQ A T+ L +GR ILG+G GE E PYG ++++ V+RFEEAL Sbjct 83 VSAVVDTVRRHPAMLAQTALTIDHLAKGRFILGLGSGESENTLPYGFDFSRSVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 A I+ LW S+G + + ++ L +A D PY G+ P IW+ A GPRML GRYAD W Sbjct 143 AVIQLLWRSDGP-VDFDGQFYSLRHARLDTEPYEGRLPPIWIGASGPRMLDIAGRYADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y++ L AVR++A AGRDPM+ITP ++ + G + + E L++ +VK Sbjct 202 WPAGAWTPEHYAQMLAAVRASADRAGRDPMAITPCFIQVCLIGTDDAALAEILQAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + + G +HPMG D+ G QDI P + + ++ + ++ VV GTP Sbjct 262 FLLQVSAKTLSDFGFDHPMGPDWRGFQDIDPAVLTRDRIVQFLGDAHPEMVLAVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 V V + D GLR +++ Sbjct 322 KAVAKIVKTYVDAGLRVPKILD 343 >gi|240168925|ref|ZP_04747584.1| N5,N10-methylenetetrahydromethanopterin reductase-related protein [Mycobacterium kansasii ATCC 12478] Length=384 Score = 204 bits (519), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 141/366 (39%), Positives = 208/366 (57%), Gaps = 8/366 (2%) Query 18 PPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAK-FVPKIDANYEPWT 76 PP AR+ + AA +S + DH + VPR+I + +AA+ P +Y+ Sbjct 16 PPLSSARALLLAARAARLESVMLIDHFQSAVPRAIWNKDLSWLAAQDQSPHEFFDYQ--V 73 Query 77 MLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPY 136 +LG LA RLRLGV VT+A RR+P + AQA TL LTR ILGIG GER +PY Sbjct 74 LLGYLA-SRAGRLRLGVGVTEAIRRHPVLIAQAMLTLSHLTRRAPILGIGAGERMNIDPY 132 Query 137 GVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAH 196 G+++++PV R EEAL IR ++ G I+ +F L A DL RG+ P+IWV H Sbjct 133 GLDFSEPVTRLEEALQVIRLCLSTRGP-ITFSGKHFQLDRATMDLDAPRGRVPQIWVGGH 191 Query 197 GPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRN 256 GPRMLR TGRY D W P+ VV P +Y+ L V++AA++AGRD SITPA R + G Sbjct 192 GPRMLRLTGRYGDGWYPVTVVSPQEYAAKLAVVQAAAAEAGRDAGSITPALHRFAVIGAT 251 Query 257 RDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAK 316 + L++ +++ L P E W + G HP+GA F + +P +++ + + A Sbjct 252 EREARAMLDTKAIRLLGLVAPAEVWRQAGAVHPLGAHFDAFVNFVPDRHNRRAIEAAIAA 311 Query 317 VPAALMKE-VVFSGTPDEVIDQVAEWRDHGLRYVVL--INGSLVNPSLRKTVTAVLPHAK 373 VP A+M E + G+P +V ++ + D G+R+VVL ++G + + R + A L A+ Sbjct 312 VPDAVMTEGPLLWGSPRQVAAKLRAFGDAGMRHVVLAPVSGLVSQRAARYGLWATLRIAR 371 Query 374 VLRGLK 379 +L G + Sbjct 372 LLNGRR 377 >gi|296167075|ref|ZP_06849486.1| luciferase family protein [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295897565|gb|EFG77160.1| luciferase family protein [Mycobacterium parascrofulaceum ATCC BAA-614] Length=375 Score = 204 bits (519), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 120/322 (38%), Positives = 175/322 (55%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A A+ P L LA L + L Sbjct 30 SIWLPDHMVSFWPDSIWTPEFTDLAT-------ASPSPHRHLDGLAVAAAAAVLTENVPL 82 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+P++ AQ A T+ L +GR ILG+G GE E PYG ++++PV+RFEEAL Sbjct 83 VSAVVDTVRRHPSMLAQTALTIDHLAKGRFILGLGSGESENTLPYGFDFSRPVSRFEEAL 142 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+S+G + + ++ L +A D PY G+ P+IW+ A GPRML GR+AD W Sbjct 143 TVIRLLWDSDGP-VDFDGRFYSLRHARLDTEPYAGRPPQIWIGASGPRMLDIAGRHADGW 201 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y+ L VR++A AGRDP++ITP ++ + G + D + E L + +VK Sbjct 202 WPAGAWTPEHYAEMLGVVRASAERAGRDPLAITPCFIQVCLIGEDDDALAEILRAPLVKA 261 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V E G EHPMG + G QDI P + ++ ++ + K ++ VV GTP Sbjct 262 FLLQVSAETLRGFGFEHPMGDRWRGFQDIDPAVLTRERIIDFLDKARPEMILAVVPHGTP 321 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V + D GLR +++ Sbjct 322 TQVAKIVKTYVDAGLRVPKILD 343 >gi|315445312|ref|YP_004078191.1| flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase [Mycobacterium sp. Spyr1] gi|315263615|gb|ADU00357.1| flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase [Mycobacterium sp. Spyr1] Length=371 Score = 200 bits (509), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 126/319 (40%), Positives = 173/319 (55%), Gaps = 4/319 (1%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVT 96 S W+ DHL + P SI T E+ +A + P + + G +A +R RL V Sbjct 30 SLWMPDHLVSFWPDSIWTPEFTDLA-EVSPSPHRYLDTLALAGAVAVRT-TRTRLATSVL 87 Query 97 DAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRA 156 D RR+P + AQ+A TL L+ GR ILG+G GERE PYG + V+RF EAL IR Sbjct 88 DTVRRHPVMLAQSALTLSHLSDGRFILGLGAGERENLAPYGFDPRGTVSRFAEALQLIRL 147 Query 157 LWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVV 216 LWN++G I YF L +A D +R P IW+ A+GPRML G Y D W P Sbjct 148 LWNADGP-IDFTGRYFTLEHARLDTEVHRSGPPPIWIGANGPRMLHLVGEYGDGWWPTGS 206 Query 217 VRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGV 276 P Y+R L +R AA AGRDP +ITPA + + G D++ E L+ +VK L + Sbjct 207 AGPETYARQLARIREAAERAGRDPQAITPAKMVVCLIGEP-DELREILQRPLVKSLVLQL 265 Query 277 PGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVID 336 +A A G HPMG + G+QDI P+ + + +L +V A + VV GTP +V Sbjct 266 TADALAATGHRHPMGEHWRGIQDIDPRVLTRDRLLRLFEQVDPAAILSVVPHGTPTQVAA 325 Query 337 QVAEWRDHGLRYVVLINGS 355 QVAE+ + G R V +++ S Sbjct 326 QVAEFGEAGARVVSVLDYS 344 >gi|145224981|ref|YP_001135659.1| luciferase family protein [Mycobacterium gilvum PYR-GCK] gi|145217467|gb|ABP46871.1| luciferase family protein [Mycobacterium gilvum PYR-GCK] Length=371 Score = 200 bits (509), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 126/319 (40%), Positives = 173/319 (55%), Gaps = 4/319 (1%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGVCVT 96 S W+ DHL + P SI T E+ +A + P + + G +A +R RL V Sbjct 30 SLWMPDHLVSFWPDSIWTPEFTDLA-EVSPSPHRYLDTIALAGAVA-ARTTRTRLATSVL 87 Query 97 DAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALATIRA 156 D RR+P + AQ+A TL L+ GR ILG+G GERE PYG + V+RF EAL IR Sbjct 88 DTVRRHPVMLAQSALTLSHLSDGRFILGLGAGERENLAPYGFDPRGTVSRFAEALQLIRL 147 Query 157 LWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVV 216 LWN++G I YF L +A D +R P IW+ A+GPRML G Y D W P Sbjct 148 LWNADGP-IDFTGRYFTLEHARLDTEVHRSGPPPIWIGANGPRMLHLVGEYGDGWWPTGS 206 Query 217 VRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTALGV 276 P Y+R L +R AA AGRDP +ITPA + + G D++ E L+ +VK L + Sbjct 207 AGPETYARQLTRIREAAERAGRDPQAITPAKMVVCLIGEP-DELREILQRPLVKSLVLQL 265 Query 277 PGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTPDEVID 336 +A A G HPMG + G+QDI P+ + + +L +V A + VV GTP +V Sbjct 266 TADALADTGHRHPMGQRWRGIQDIDPRVLTRDRLLRLFEQVDPAAILSVVPHGTPTQVAA 325 Query 337 QVAEWRDHGLRYVVLINGS 355 QVAE+ + G R V +++ S Sbjct 326 QVAEFGEAGARVVSVLDYS 344 >gi|11499987|ref|NP_071233.1| hypothetical protein AF2411 [Archaeoglobus fulgidus DSM 4304] gi|2650688|gb|AAB91255.1| conserved hypothetical protein [Archaeoglobus fulgidus DSM 4304] Length=363 Score = 196 bits (497), Expect = 7e-48, Method: Compositional matrix adjust. Identities = 112/340 (33%), Positives = 180/340 (53%), Gaps = 13/340 (3%) Query 17 LPPTLPARSSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWT 76 PP + G D+ WV DHL P + I A P Y+ + Sbjct 10 FPPIEEVPKTAKRMEEKGYDAIWVADHLMGWYPHDLWKE---TIFAMRYPSCHMFYDAFC 66 Query 77 MLGNLAFGLPS--RLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNE 134 + + P+ +++ G VT+ RR+PAV Q A T + T+GR ILG+G GE E Sbjct 67 ---EICYAAPATEKIKFGTSVTEVFRRHPAVLLQQAVTANHATKGRFILGLGAGEAENIV 123 Query 135 PYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEIWV 193 PYG++++KPVAR EEA+ ++ + NS+ GE I+ E ++ L +A+FD+ P + P W Sbjct 124 PYGIDFSKPVARLEEAVEVMKLMLNSDYGEPINYEGKFYRLEDAVFDIKPI-SEIP-FWF 181 Query 194 AAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIIT 253 AHG RML+ T ++ D W+P + P Y E + S A + GR+P IT A +I Sbjct 182 GAHGNRMLKLTAKHGDGWLP-TTLPPEVYRERAEKLDSFAKEFGREPEEITKAIFVSLIV 240 Query 254 GRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSY 313 ++VE+ L+S ++K+ AL +P E + G +HP G F G+ D IP K+ ++ Sbjct 241 DEKPEEVEKLLKSPILKVHALLMPSEFYEMLGYKHPFGK-FYGLLDYIPTKYTKEQIMEA 299 Query 314 AAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLIN 353 +VP +M+ +GTP+E++ Q ++ G+ ++V+ N Sbjct 300 IKQVPDEIMRIAYIAGTPEEIVQQFEQYEKLGVSHIVIWN 339 >gi|108798866|ref|YP_639063.1| luciferase-like protein [Mycobacterium sp. MCS] gi|119867981|ref|YP_937933.1| luciferase family protein [Mycobacterium sp. KMS] gi|108769285|gb|ABG08007.1| luciferase-like protein [Mycobacterium sp. MCS] gi|119694070|gb|ABL91143.1| luciferase family protein [Mycobacterium sp. KMS] Length=391 Score = 195 bits (495), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 119/322 (37%), Positives = 173/322 (54%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A D + P L +A L L Sbjct 46 SIWLPDHMVSFWPDSIWTPEFTDLA-------DTSPSPHRHLDGMAVAAAAAVLTESTPL 98 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA AQ+A T+ L+ GR ILG+G GE E PYG ++ +PV+RFEEAL Sbjct 99 ATAVVDTVRRHPASLAQSALTIDHLSGGRFILGLGSGEAENIVPYGFDFDRPVSRFEEAL 158 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+S+G + + L A D P+ G+ P IW+ A GPRML GR+AD W Sbjct 159 HVIRLLWDSDGP-VDFTGRFHRLRGARLDTEPFGGRVPPIWIGASGPRMLDLVGRHADGW 217 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y+ L AVRS+A AGRDPM+ITP ++ + ++ + E L++ +VK Sbjct 218 WPAGAWTPQHYADMLGAVRSSAERAGRDPMAITPCFIQVCLIAKDDAALAEILDAPLVKA 277 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G EHPMG D+ G DI P T+ ++ ++ + A+V + V+ GTP Sbjct 278 FLLQVSAQTLRAFGHEHPMGDDWRGFHDIDPATLTRERIVDFLARVRPEAILAVLPHGTP 337 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V ++ + GLR +++ Sbjct 338 AQVARTVKDYVEAGLRVPKIMD 359 >gi|126434466|ref|YP_001070157.1| luciferase family protein [Mycobacterium sp. JLS] gi|126234266|gb|ABN97666.1| luciferase family protein [Mycobacterium sp. JLS] Length=391 Score = 195 bits (495), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 119/322 (37%), Positives = 173/322 (54%), Gaps = 13/322 (4%) Query 37 SYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFG-----LPSRLRL 91 S W+ DH+ + P SI T E+ +A D + P L +A L L Sbjct 46 SIWLPDHMVSFWPDSIWTPEFTDLA-------DTSPSPHRHLDGMAVAAAAAVLTESTPL 98 Query 92 GVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEAL 151 V D RR+PA AQ+A T+ L+ GR ILG+G GE E PYG ++ +PV+RFEEAL Sbjct 99 ATAVVDTVRRHPASLAQSALTIDHLSGGRFILGLGSGEAENIVPYGFDFDRPVSRFEEAL 158 Query 152 ATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAW 211 IR LW+S+G + + L A D P+ G+ P IW+ A GPRML GR+AD W Sbjct 159 HVIRLLWDSDGP-VDFTGRFHRLRGARLDTEPFGGRVPPIWIGASGPRMLDIVGRHADGW 217 Query 212 IPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKM 271 P P Y+ L AVRS+A AGRDPM+ITP ++ + ++ + E L++ +VK Sbjct 218 WPAGAWTPQHYADMLGAVRSSAERAGRDPMAITPCFIQVCLIAKDDAALAEILDAPLVKA 277 Query 272 TALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVVFSGTP 331 L V + G EHPMG D+ G DI P T+ ++ ++ + A+V + V+ GTP Sbjct 278 FLLQVSAQTLRAFGHEHPMGDDWRGFHDIDPATLTRERIVDFLARVRPEAILAVLPHGTP 337 Query 332 DEVIDQVAEWRDHGLRYVVLIN 353 +V V ++ + GLR +++ Sbjct 338 AQVARTVKDYVEAGLRVPKIMD 359 >gi|317126230|ref|YP_004100342.1| Luciferase-like, subgroup [Intrasporangium calvum DSM 43043] gi|315590318|gb|ADU49615.1| Luciferase-like, subgroup [Intrasporangium calvum DSM 43043] Length=378 Score = 191 bits (486), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 120/355 (34%), Positives = 180/355 (51%), Gaps = 11/355 (3%) Query 30 ATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRL 89 A G DS W DHL P+ + E +A K + +P + A R+ Sbjct 24 AEARGYDSLWWPDHLMGFHPQQLWQPEITELA-KSISSPHVFIDPVAAIAACAVHT-ERI 81 Query 90 RLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEE 149 LG VTD+ RR+PA+ AQ TL ++GRA+LGIG GE E PYG+ ++KPV+R EE Sbjct 82 MLGTSVTDSIRRHPAMLAQEFLTLDHFSKGRAVLGIGAGEGENITPYGLSFSKPVSRLEE 141 Query 150 ALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKW------PEIWVAAHGPRMLRA 203 +L +R LW S GE + + ++ L +A+ + PY P IW AHGPRML Sbjct 142 SLEIVRLLW-STGEPVDFDGEWWSLRDAVCGIRPYGSDEDGKPLPPPIWCGAHGPRMLSI 200 Query 204 TGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEA 263 TGR D W+P P +S +RSAA+ A R TP + ++ + +V+ Sbjct 201 TGRLCDGWLPTYQGGPEPWSEGYSKIRSAAATAKRALDRFTPGLLAHVVVAESDAEVDRM 260 Query 264 LESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMK 323 L+S +++ L +P A+ GV HP+G G+ D IP + VL VP L + Sbjct 261 LDSPLIRAWMLTLPSSAFEEFGVVHPLGEGAYGLLDYIPTRLSDDQVLKALRAVPEGLAR 320 Query 324 EVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVN--PSLRKTVTAVLPHAKVLR 376 + + +GTPD + ++ ++ D G+ +VVL N + + LR + A+ A LR Sbjct 321 KYLLAGTPDRITQELRQFADRGMAHVVLWNLTYLGDFAQLRSSFGALDEIADELR 375 >gi|336255154|ref|YP_004598261.1| 5,10-methylenetetrahydromethanopterin reductase [Halopiger xanaduensis SH-6] gi|335339143|gb|AEH38382.1| 5,10-methylenetetrahydromethanopterin reductase [Halopiger xanaduensis SH-6] Length=360 Score = 137 bits (345), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 101/309 (33%), Positives = 153/309 (50%), Gaps = 9/309 (2%) Query 68 IDANYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGV 127 +D +E +T+LG +A R + VTD+ RR+P A + TL +T GRA LGIG Sbjct 56 VDPPWEAFTVLGAIA-QHTDRATIMPGVTDSVRRHPTELAHSTVTLDRMTDGRAALGIGA 114 Query 128 GEREGNEPY-GVEWTKPVARFEEALATIRALWNSNGEL-ISRESPYFPLHNALFDLPPYR 185 GE P +EW P ++F EA+ I LWNS + S + ++ L +A L P + Sbjct 115 GEAFNFTPMTDIEWDDPFSQFVEAVKVIDGLWNSQADDPFSFDGDFYGLEDAHMGLKPVQ 174 Query 186 GKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITP 245 P IWV +GP M G AD W P + P Y+ LE V SAA D GRDP I Sbjct 175 DPRPPIWVGGYGPSMRGFAGAVADGWFPW-IHSPDQYAADLERVLSAAEDRGRDPEEIDR 233 Query 246 AAVRGIITGRNRDDVEEALESVVVK-MTALGVPGEAWARHGVEHPMGADFSGVQDIIPQT 304 A ++ DD +EA E V + T L + A G E + + ++D+ Sbjct 234 AV---MVPTTVTDDADEAREIAVERNRTTLALRPPLLAEMGYEE-IAEETPIMRDMAFTD 289 Query 305 MDKQTVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKT 364 ++ +LS A ++PA + EV SG P+ I+++ + D G+ +VLI + +LR Sbjct 290 EQEEQLLSAAERIPAEAVDEVTISGDPERAIERIEAFADAGVDNLVLIPVGDFDETLRHY 349 Query 365 VTAVLPHAK 373 ++P+ + Sbjct 350 EDEIVPYFR 358 >gi|288931564|ref|YP_003435624.1| Luciferase-like, subgroup [Ferroglobus placidus DSM 10642] gi|288893812|gb|ADC65349.1| Luciferase-like, subgroup [Ferroglobus placidus DSM 10642] Length=354 Score = 134 bits (336), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 106/322 (33%), Positives = 154/322 (48%), Gaps = 30/322 (9%) Query 33 MGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLG 92 +G DSYW+ DHL +AT V + DA E W LG LA L ++ + Sbjct 32 LGFDSYWMPDHL-------VATG---------VKRWDA-IEAWGALGALAV-LTEKIMIA 73 Query 93 VCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALA 152 V+D R +PAV AQ A T+ +++ GRAILGIG+GE P+G+E+ KPV R EAL Sbjct 74 TGVSDTYRVHPAVLAQKATTIDIISNGRAILGIGIGEAMNLVPFGIEYDKPVGRTIEALE 133 Query 153 TIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWI 212 IR L N + + E Y+ L A P + I+VA PR +R G+Y D W+ Sbjct 134 VIRRLLNED--FVDFEGKYYKLKQAFIAPKPVQKPHYPIYVAGASPRTIRMAGKYGDGWL 191 Query 213 PIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVV--K 270 P + Y E V AA + G+DP I A + + +D EA E V++ K Sbjct 192 P-ANLTVEKYKEGRETVMKAAKEVGKDPEKIDMAHFMYGVIAKTKD---EARERVMLPAK 247 Query 271 MTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALM-KEVVFSG 329 + L P G E P + + P+ D Q L A K+P ++ K + G Sbjct 248 LLLLTRP-RILEAIGYEPPTYDFEMTFKLVFPR--DAQRWLEEAKKLPDEVVEKSPIVYG 304 Query 330 TPDEVIDQVAEWRDHGLRYVVL 351 T D+ I++ ++ G R+ V+ Sbjct 305 TVDDFIERFEQYYKVGCRHFVM 326 >gi|167042605|gb|ABZ07327.1| putative Luciferase-like monooxygenase [uncultured marine crenarchaeote HF4000_ANIW133K13] Length=361 Score = 129 bits (325), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 91/307 (30%), Positives = 147/307 (48%), Gaps = 10/307 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML +A + + + LG CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 55 DPWVMLSAIA-AVTNHVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 113 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + I+ L+ S + E Y+ L +A PP R P I Sbjct 114 LKEFCIPFEKPVSKWEEQIQVIKKLYGSTPDNTVDFEGKYYKLESACLQAPPIRKPHPPI 173 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L TG+Y D W+PI P + + + + ++ R + Sbjct 174 YMASGGKRTLSLTGKYGDGWLPIGYT-PELFKDHKKQIEVSMNENNRTQEEKDNFQMALD 232 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQ--- 308 I DD EE+ + + E H ++ G DF V+ +M Q Sbjct 233 IDVYFSDDAEESWAKMKEAVKVSLFKPEVLRVHQLKDIEGFDF--VKYFTEYSMSNQDWI 290 Query 309 -TVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A K+P A+ + GTPD++I + G+ +V+ G S+ K T Sbjct 291 IKMREAATKIPDAVARSSTGVGTPDDIIPIFERFVKAGVNHFVIRFWGKNYFGSIDKFAT 350 Query 367 AVLPHAK 373 V+P+ K Sbjct 351 HVIPYFK 357 >gi|167044276|gb|ABZ08956.1| putative Luciferase-like monooxygenase [uncultured marine crenarchaeote HF4000_APKG5N21] Length=361 Score = 125 bits (315), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 87/307 (29%), Positives = 151/307 (50%), Gaps = 10/307 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML ++A + + + LG CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 55 DPWVMLSSIA-AVTNHVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 113 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + I+ L+ S+ + E Y+ L +A R P I Sbjct 114 LKEFCIPFDKPVSKWEEQIQVIKKLYGSSPDNTVDFEGKYYKLESACLQASSIRKPHPPI 173 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L+ TG+Y D W+PI P + + + ++ ++ R + Sbjct 174 YMASGGKRTLKLTGKYGDGWLPIGYT-PELFEDHKKQIEASMNENNRTQEEKDNFQMALD 232 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQT-- 309 I DD EE+ + + E H ++ G DF V+ +M Q+ Sbjct 233 IDVYFSDDAEESWARMKEAVKVSLFKPEILRVHELKDIEGFDF--VKYFTEYSMSNQSWI 290 Query 310 --VLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A K+P A+ + GTPD++I ++ G+ +V+ G S+ + + Sbjct 291 VKMREAATKIPDAIARSSTGVGTPDDIIPIFEKFIKAGVNHFVIRFWGKNYFGSIDRFAS 350 Query 367 AVLPHAK 373 V+P+ K Sbjct 351 QVIPYFK 357 >gi|167045692|gb|ABZ10340.1| putative Luciferase-like monooxygenase [uncultured marine crenarchaeote HF4000_APKG10L15] Length=361 Score = 125 bits (313), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 87/307 (29%), Positives = 150/307 (49%), Gaps = 10/307 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML ++A + + + LG CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 55 DPWVMLSSIA-AVTNHVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 113 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + I+ L++S+ + E Y+ L +A R P Sbjct 114 LKEFCIPFDKPVSKWEEQIQVIKKLYSSSPDNTVDFEGKYYKLESACLQASSIRKPHPPT 173 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L+ TG+Y D W+PI P + + + ++ ++ R + Sbjct 174 YMASGGKRTLKLTGKYGDGWLPIGYT-PELFEDHKKQIEASMNENNRTQEEKDNFQMALD 232 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQT-- 309 I DD EE+ + + E H ++ G DF V+ +M Q+ Sbjct 233 IDVYFSDDAEESWARMKEAVKVSLFKPEILRVHELKDIEGFDF--VKYFTEYSMSNQSWI 290 Query 310 --VLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A K+P A+ + GTPD++I + G+ +V+ G S+ K + Sbjct 291 VKMREAATKIPDAIARSSTGVGTPDDIIPIFERFIKAGVNHFVIRFWGKNYFGSIDKFAS 350 Query 367 AVLPHAK 373 V+P+ K Sbjct 351 QVIPYFK 357 >gi|161528617|ref|YP_001582443.1| luciferase family protein [Nitrosopumilus maritimus SCM1] gi|160339918|gb|ABX13005.1| luciferase family protein [Nitrosopumilus maritimus SCM1] Length=368 Score = 125 bits (313), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 88/304 (29%), Positives = 141/304 (47%), Gaps = 10/304 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML +A + + + LG CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 61 DPWVMLSAIA-AVTNNVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 119 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + TI L+ S + E Y+ L A PP R P Sbjct 120 LKEFCIPFEKPVSKWEEQIETIHTLYKSTPDNTVDYEGKYYKLEGACLQAPPIRKPHPPT 179 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L TG+ D W+PI P + ++ + + R Sbjct 180 YMASGGKRTLALTGKLGDGWLPIGYT-PELFEDHAAQIKKSMDENNRTQEEKDNFQYALD 238 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQ--- 308 I +D EE+ + + E H ++ G DF V+ +M Q Sbjct 239 IDVYFSEDAEESWARMKEAVKVSLFKPEVLRVHNLKEIEGFDF--VKYFTEYSMSNQEWI 296 Query 309 -TVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A K+P A+ + GTPD++I + D G+ +V+ G S+ K + Sbjct 297 VKMREAATKIPEAVARSSTAVGTPDDIIPTFERFMDAGVNHFVIRFWGKNYFGSIDKFAS 356 Query 367 AVLP 370 V+P Sbjct 357 HVMP 360 >gi|340345165|ref|ZP_08668297.1| Luciferase family protein [Nitrosopumilus sp. MY1] gi|339520306|gb|EGP94029.1| Luciferase family protein [Nitrosopumilus sp. MY1] Length=367 Score = 122 bits (307), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 84/307 (28%), Positives = 146/307 (48%), Gaps = 10/307 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML +A + + + LG CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 60 DPWVMLSAIA-AVTNNVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 118 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + I+ L+ S ++ + Y+ L A PP R P Sbjct 119 LKEFCIPFEKPVSKWEEQIQVIKTLYGSTPDNTVNYDGKYYKLEGACLQAPPIRKPHPPT 178 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L TG+ + W+PI P + + ++++ + R Sbjct 179 YMASGGTRTLELTGKLGEGWLPIGYT-PELFEDHAKQIQTSMNKHNRTQEEKDKFQYALD 237 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQT-- 309 I +D EE+ + + E HG++ G DF V+ +M Q+ Sbjct 238 IDVYFSEDAEESWAKMKEAVKVSLFKPEVLRVHGIKEIEGFDF--VKYFTEYSMSDQSWI 295 Query 310 --VLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A K+P + + GTPD++I + G+ +V+ G S+ K + Sbjct 296 VKMREAATKIPDKIARSSTAVGTPDDIIPTFERFMKAGVNHFVIRFWGKNYFGSIDKFAS 355 Query 367 AVLPHAK 373 V+P+ + Sbjct 356 HVMPYLR 362 >gi|329765467|ref|ZP_08257043.1| luciferase family protein [Candidatus Nitrosoarchaeum limnia SFB1] gi|329137905|gb|EGG42165.1| luciferase family protein [Candidatus Nitrosoarchaeum limnia SFB1] Length=367 Score = 122 bits (306), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 84/307 (28%), Positives = 145/307 (48%), Gaps = 10/307 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML +A + + + LG CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 60 DPWVMLSAIA-AVTNNVELGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 118 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + I+ L+ S ++ Y+ L A PP R P Sbjct 119 LKEFCIPFEKPVSKWEEQIQVIKTLYGSTPDNTVNYNGKYYKLEGACLQAPPIRKPHPPT 178 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L TG+ + W+PI P + + ++++ + R Sbjct 179 YMASGGTRTLELTGKLGEGWLPIGYT-PELFEDHAKQIQTSMNKHNRTQQEKDNFQYALD 237 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQT-- 309 I +D EE+ + + E HG++ G DF V+ +M Q+ Sbjct 238 IDVYFSEDAEESWAKMKEAVKVSLFKPEILRVHGIKEIEGFDF--VKYFTEYSMSDQSWI 295 Query 310 --VLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A K+P + + GTPD++I + G+ +V+ G S+ K + Sbjct 296 VKMREAATKIPDKIARSSTAVGTPDDIIPTFERFMKAGVNHFVIRFWGKNYFGSIDKFAS 355 Query 367 AVLPHAK 373 V+P+ + Sbjct 356 HVMPYLR 362 >gi|292494275|ref|YP_003533418.1| Luciferase-like monooxygenase superfamily [Haloferax volcanii DS2] gi|291369109|gb|ADE01339.1| Luciferase-like monooxygenase superfamily [Haloferax volcanii DS2] Length=360 Score = 120 bits (302), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 105/355 (30%), Positives = 158/355 (45%), Gaps = 42/355 (11%) Query 30 ATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRL 89 A G D+ V DHL + EYL +D +E +++LG +A + Sbjct 31 AETAGFDTVTVPDHLF----HPTGSEEYL---------VDPPWEAFSVLGAIA-QRTEEV 76 Query 90 RLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYG-VEWTKPVARFE 148 L V D+ RR+P A ATL +T GRA LGIG GE P ++W P RF Sbjct 77 TLMPGVADSVRRHPTELAHVTATLDRMTDGRAGLGIGAGEAFNFAPISDIDWDDPYTRFR 136 Query 149 EALATIRALWNS-NGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRY 207 E +A I LWNS E S YF L A L P + P +W+ +G M TG Sbjct 137 ECVAVIDGLWNSTTDEPFSFAGDYFDLDEAHMGLNPAQEPRPPLWIGGYGESMRGLTGAV 196 Query 208 ADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEA-LES 266 AD W P + P +Y+ L V A+D GRDP +I A + + D+ A +E Sbjct 197 ADGWFPW-IYSPDEYAADLRKVLDVAADRGRDPDAIDRAVMVPTTVSEDGDEARAAGIER 255 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQT---------MDKQTVLSYAA-K 316 V + + P+ AD G +DI T +++ LS AA + Sbjct 256 NRVNL-------------ALRPPLLADM-GYEDIAESTPIMWQMAFDEEQERQLSAAAER 301 Query 317 VPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPH 371 +P + ++ +G P+ VI+++ +RD G+ +VLI ++R ++P+ Sbjct 302 IPDGAVDDICVAGDPERVIERIEAFRDAGVDNLVLIPVGDYEETMRHYENEIIPY 356 >gi|288930460|ref|YP_003434520.1| luciferase [Ferroglobus placidus DSM 10642] gi|288892708|gb|ADC64245.1| Luciferase-like, subgroup [Ferroglobus placidus DSM 10642] Length=338 Score = 119 bits (299), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 96/323 (30%), Positives = 156/323 (49%), Gaps = 43/323 (13%) Query 34 GADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLGV 93 G DS + DHL +GI K YE +++LG LA +R LGV Sbjct 27 GFDSIFTPDHL-------------VGIGLKNF----YAYEAFSILGYLA--GKTRATLGV 67 Query 94 CVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALAT 153 CV+D RRNPAV AQAA+T+ ++ ILG+G GE P+G+E V++ EE + Sbjct 68 CVSDVLRRNPAVVAQAASTIASMSGREFILGLGAGEGMNLLPFGIETKFLVSKLEEGVKI 127 Query 154 IRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIP 213 IR L +G ++S E +F + +A +PP + +IWVA + P+ + T +YAD WIP Sbjct 128 IRELL--SGRVVSYEGKFFRMKDAF--VPP--SENVKIWVAGNSPKTMEITAKYADGWIP 181 Query 214 IVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMTA 273 + Y L+ + R + + ++ D+ E +E + K A Sbjct 182 TATMGEKRYEENLKKIV-------RKHRKVEAGLFAYTVVAKSYDEAREMIE-IPGKFIA 233 Query 274 LGVP--GEAWARHGVEHPMGADFSGVQDIIPQTMDKQTV---LSYAAKVPAALMKEVVFS 328 L P GE + G++ D +I+ T K+ V L A ++P L++ F Sbjct 234 LLSPFRGEFLKKVGIDE---KDLP--PNILHFTFTKENVEKLLEVAKQIPFELVERRYFY 288 Query 329 GTPDEVIDQVAEWRDHGLRYVVL 351 G+P++V +++ ++ G+ + VL Sbjct 289 GSPEDVAERMEKFVKAGVEHFVL 311 >gi|333911162|ref|YP_004484895.1| 5,10-methylenetetrahydromethanopterin reductase [Methanotorris igneus Kol 5] gi|333751751|gb|AEF96830.1| 5,10-methylenetetrahydromethanopterin reductase [Methanotorris igneus Kol 5] Length=331 Score = 119 bits (299), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 91/294 (31%), Positives = 145/294 (50%), Gaps = 16/294 (5%) Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 ++++LG VT+ RNPA+TA A ATL L+ GRA+LGIG G++ + G+EW KPV Sbjct 54 NKIKLGPGVTNPYVRNPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTT 113 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 +E++ +R L GE +S + + A + P + K P ++V A GP+ML G Sbjct 114 LKESIEVMRKLL--AGERVSFDGNVVKVAGAALAVKPIQKKVP-VYVGAQGPKMLETAGM 170 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 266 AD + I P D+ A+ ++ A AGR I AA + +N + ++A Sbjct 171 IADGVL-INASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNAEKAKQAAVP 229 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 326 VV A G P RHG+ D V+ I + + K + V A+++ Sbjct 230 VVA-FIAAGSPPVVLERHGI------DMEKVEK-IREALKKGDFGTAFGTVDDAMLEAFS 281 Query 327 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKK 380 GTP+EV+++ + + G+ +V GS + P+ K L KV+ LK+ Sbjct 282 IYGTPEEVVEKCKKLAEMGVTQIVA--GSPIGPN--KETAIKLIGKKVIPALKE 331 >gi|288931128|ref|YP_003435188.1| 5,10-methylenetetrahydromethanopterin reductase [Ferroglobus placidus DSM 10642] gi|288893376|gb|ADC64913.1| 5,10-methylenetetrahydromethanopterin reductase [Ferroglobus placidus DSM 10642] Length=332 Score = 119 bits (298), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 87/298 (30%), Positives = 143/298 (48%), Gaps = 13/298 (4%) Query 71 NYEPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGER 130 N + ML LA S+++LG VT+ +PA+TA A AT++ L+ GRA+LGIG G++ Sbjct 39 NRNVYAMLAILALK-TSKIKLGPGVTNPYHISPALTASAIATINELSEGRAVLGIGAGDK 97 Query 131 EGNEPYGVEWTKPVARFEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPE 190 E G+ W KP+ R EA+ IRAL +G+ ++ + F ++ A D G P Sbjct 98 VTFERIGITWEKPLKRMREAVEIIRAL--HSGKPVNYDGEIFKMNGAKLDFKA--GNIP- 152 Query 191 IWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRG 250 I++ A GP+ML+ D + I P D+ A E + + S AG+ A Sbjct 153 IYIGAQGPKMLQLAAELGDG-VLINASHPRDFEAAKENIEAGLSKAGKSKEEFDVVAYAS 211 Query 251 IITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTV 310 + ++R+ A +VV G P + RHG+ D + V++ + K Sbjct 212 MSVDKDREKARNAAR-IVVAFIVAGSPEVIFERHGISMD---DVNKVREALNNAFTKGDW 267 Query 311 LSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAV 368 V ++ SGTP++VI+++ E G+ VV GS + P +K++ + Sbjct 268 AGVGKAVTDEMIDCFSISGTPEDVIERIKELSKAGVTQVVA--GSPIGPDKKKSIQLI 323 >gi|315425300|dbj|BAJ46967.1| N5,N10-methylenetetrahydromethanopterin reductase [Candidatus Caldiarchaeum subterraneum] gi|315426067|dbj|BAJ47714.1| N5,N10-methylenetetrahydromethanopterin reductase [Candidatus Caldiarchaeum subterraneum] gi|343484876|dbj|BAJ50530.1| N5,N10-methylenetetrahydromethanopterin reductase [Candidatus Caldiarchaeum subterraneum] Length=357 Score = 118 bits (296), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 98/323 (31%), Positives = 149/323 (47%), Gaps = 19/323 (5%) Query 64 FVPKIDANY-EPWTMLGNLAFG-LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRA 121 VP + +Y T+L AFG L +R+ VTD RR+P AQA ATL +LT GRA Sbjct 43 IVPNAEVSYPNAQTLLA--AFGVLTKHVRISTAVTDCYRRHPVEIAQAIATLDVLTHGRA 100 Query 122 ILGIGVGEREGNEPYGVEWTKPVARFEEALATIRALWNSNGEL-ISRESPYFPLHNALFD 180 +LGIG GE P+G+EWTKPV R EA+ I L S + + E F L A Sbjct 101 VLGIGAGEMMNLSPFGIEWTKPVKRLREAVEVINLLLASTPKSPATYEGEIFSLKKAYLQ 160 Query 181 LPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDP 240 + P + P I++ A G + G D W+P+ V P + L V++ A R Sbjct 161 IKPVQKPRPPIYIGAAGCKTRELVGMVGDGWLPVGVESPQTLKKHLLDVKNGAERTSR-- 218 Query 241 MSITPAAVRGIITGRNRDDVEEALESVVVKMTALGVPGEAWARH--GVEHPMGADFSGVQ 298 I+ + + +D+E A V + ++ V R G+E P + +Q Sbjct 219 -QISNIDIDVTVYTAVDEDIENAYRVVSPAVKSMLVQQREVLRELTGLEVP---ENLSLQ 274 Query 299 DIIPQTMDKQTVLSY---AAKVPAALMKEVVFSGTPDEVIDQVAEWRDHG-LRYVVLING 354 I P DK+ ++S+ +VP + +++V G D VI ++ E+ G + I G Sbjct 275 RIDP--TDKERLMSFEEMVKQVPRSAVEDVAAFGPIDSVIGKLEEFLGAGATSLTICIIG 332 Query 355 SLVNPSLRKTVTAVLPHAKVLRG 377 +LR ++P+ K G Sbjct 333 LDHEKTLRTYAEKIIPYLKETYG 355 >gi|118575742|ref|YP_875485.1| flavin-dependent oxidoreductase [Cenarchaeum symbiosum A] gi|118194263|gb|ABK77181.1| flavin-dependent oxidoreductase [Cenarchaeum symbiosum A] Length=390 Score = 118 bits (295), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 86/307 (29%), Positives = 142/307 (47%), Gaps = 10/307 (3%) Query 73 EPWTMLGNLAFGLPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREG 132 +PW ML +A + + + +G CVTDA RR+P+ A AA TL +++GRAILGIG GE + Sbjct 85 DPWVMLSAIA-AITNNVEIGTCVTDAIRRHPSNIALAAITLDRVSKGRAILGIGAGEAQN 143 Query 133 NEPYGVEWTKPVARFEEALATIRALWNSN-GELISRESPYFPLHNALFDLPPYRGKWPEI 191 + + + + KPV+++EE + I+AL++S+ + Y+ L A PP R P Sbjct 144 LKEFCIPFEKPVSKWEEQIEVIKALYSSSPDNTVDYSGKYYDLKGACLQAPPIRKPHPPT 203 Query 192 WVAAHGPRMLRATGRYADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGI 251 ++A+ G R L TG+ D W+PI P + + + R + Sbjct 204 YMASGGKRTLMLTGKLGDGWLPIGYT-PELFEDHRGQIVDSMKKHDRTEEEKENFQMALD 262 Query 252 ITGRNRDDVEEALESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQ--- 308 I +D EE+ + + E H ++ G DF V+ +M Q Sbjct 263 IDVYFSEDAEESWARMKEAVKVSLFKPEVLRVHNLKEIEGFDF--VKYFTEYSMSNQEWI 320 Query 309 -TVLSYAAKVPAALMKEVVFSGTPDEVIDQVAEWRDHGL-RYVVLINGSLVNPSLRKTVT 366 + A ++P + + GTPD+VI + G+ +V+ G S+ K T Sbjct 321 VKMREAATRIPDGVARSSTAIGTPDDVIPTFERFLKAGVNHFVIRFWGKDYFGSIDKFAT 380 Query 367 AVLPHAK 373 V+PH + Sbjct 381 HVMPHLR 387 >gi|116753525|ref|YP_842643.1| methylenetetrahydromethanopterin reductase [Methanosaeta thermophila PT] gi|116664976|gb|ABK14003.1| methylenetetrahydromethanopterin reductase [Methanosaeta thermophila PT] Length=318 Score = 116 bits (290), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 93/335 (28%), Positives = 149/335 (45%), Gaps = 51/335 (15%) Query 33 MGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEPWTMLGNLAFGLPSRLRLG 92 +G ++ W+ DH N N + ++ L L+ L +R+RLG Sbjct 25 VGFETVWITDHYN-------------------------NRDVYSTLAVLSM-LTNRIRLG 58 Query 93 VCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVARFEEALA 152 VT+ R+P +TA + A+++ L+ GRAILGIG G++ + G+ W KP+ R E+++ Sbjct 59 TGVTNPYTRSPIITASSIASINELSGGRAILGIGPGDKATFDAMGIAWEKPLTRVRESVS 118 Query 153 TIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWI 212 IRAL E +++ L + ++P Y G A GP+ML G AD + Sbjct 119 VIRALLRK--ERVTQGGMNAQLSFSAGNIPIYMG--------AQGPKMLELAGEIADGVL 168 Query 213 PIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVKMT 272 I P D+ A+ +R+ AGRDP + A R+R VV Sbjct 169 -INASHPEDFRAAIPLIRNGVQRAGRDPEDVKVCAYTSFSVDRDRSKAASEARKVVA-FI 226 Query 273 ALGVPGEAWARHGVEHPMGADFSGVQ--DIIPQTMDKQTVLSYAAKVPAALMKEVVFSGT 330 A G P RHG+ GVQ D I + + K S + V ++ +GT Sbjct 227 AAGSPDAVLERHGI---------GVQERDAISKAISKGDFASAMSSVTDKMLDVFSVTGT 277 Query 331 PDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTV 365 PD+ +V E G+ +V+ GS + P +++ Sbjct 278 PDDCRARVDELLATGVNQIVV--GSPIGPDKERSI 310 >gi|289192232|ref|YP_003458173.1| 5,10-methylenetetrahydromethanopterin reductase [Methanocaldococcus sp. FS406-22] gi|288938682|gb|ADC69437.1| 5,10-methylenetetrahydromethanopterin reductase [Methanocaldococcus sp. FS406-22] Length=331 Score = 115 bits (287), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 89/294 (31%), Positives = 141/294 (48%), Gaps = 16/294 (5%) Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 ++++LG VT+ R+PA+TA A ATL L+ GRA+LGIG G++ + G+EW KPV Sbjct 54 NKIKLGPGVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTT 113 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 +E++ IR L GE +S E + A + P + K P +++ A GP+ML G Sbjct 114 LKESIEVIRKLL--AGERVSFEGKVVKIAGAALAVKPIQKKVP-VYMGAQGPKMLETAGM 170 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 266 AD + I P D+ A+ ++ A AGR I AA + +N D ++A Sbjct 171 IADGVL-INASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVP 229 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 326 VV A G P RHG+ D V+ I + V +++ Sbjct 230 VVA-FIAAGSPPVVLERHGI------DMEKVE-AIRNALKSGNFPEAFKNVDDTMLEAFS 281 Query 327 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKK 380 GTP++V+++ + + G+ +V GS + P+ K L KV+ LK+ Sbjct 282 IYGTPEDVVEKCKKLAEMGVTQIVA--GSPIGPN--KETAIKLIGKKVIPALKE 331 >gi|312136502|ref|YP_004003839.1| methylenetetrahydromethanopterin reductase [Methanothermus fervidus DSM 2088] gi|311224221|gb|ADP77077.1| methylenetetrahydromethanopterin reductase [Methanothermus fervidus DSM 2088] Length=321 Score = 114 bits (284), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 85/281 (31%), Positives = 136/281 (49%), Gaps = 25/281 (8%) Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 S ++LG VT+ R+PA+TA A ATL ++ GRA+LG+G G+++ + G+EWTKPV+ Sbjct 54 STIKLGPGVTNPYVRHPAITASAIATLDEISDGRAVLGMGPGDKKTFDALGIEWTKPVST 113 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 EA++TIR L GE + + L + P + K +I++ A GP ML+ G Sbjct 114 IREAISTIRTLL--AGEKTEKGA-------QLTGVKPVQEKI-DIYMGAQGPMMLKTAGE 163 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEA--L 264 AD + I P D+ A+ ++ A AGR SI V +D E+A Sbjct 164 IADGVL-INASNPKDFEAAIPNIKEGAESAGR---SIEDIDVAAYTCCSVDEDPEKAAGA 219 Query 265 ESVVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKE 324 +VV A G P RHG+E D I + + K + V +M+ Sbjct 220 AKIVVAFIAAGSPPPVLERHGIEKE-------AVDKIGELLGKGDFGGVSKAVDEKMMEA 272 Query 325 VVFSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTV 365 +GTPD+++ ++ + G+ + GS + P K++ Sbjct 273 FSITGTPDDIVSKIKDLEKIGVTQ--FVAGSPIGPEKEKSI 311 >gi|296108846|ref|YP_003615795.1| 5,10-methylenetetrahydromethanopterin reductase [methanocaldococcus infernus ME] gi|295433660|gb|ADG12831.1| 5,10-methylenetetrahydromethanopterin reductase [Methanocaldococcus infernus ME] Length=331 Score = 114 bits (284), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 81/282 (29%), Positives = 135/282 (48%), Gaps = 14/282 (4%) Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 ++++LG VT+ RNPA+TA A ATL L+ GRA+LGIG G++ + G+EW KPV Sbjct 54 NKIKLGPGVTNPYVRNPAITASAIATLDELSGGRAVLGIGPGDKATFDTLGIEWVKPVTT 113 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 +E + IR L GE +S + L A ++ P P +++ A GP+ML G Sbjct 114 LKETVEVIRKLL--AGERVSYDGKVVKLAGAALNVKPINKDVP-VYIGAQGPKMLETAGA 170 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 266 D + I P D+ A+ ++ A AG+ + AA + + + ++A Sbjct 171 IGDGVL-INASNPKDFEAAIPLIKKGAESAGKKLEDVDIAAYACMSVDKKSEKAKQAAVP 229 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 326 VV + A G P RH + D V+ I + + K + V A+++ Sbjct 230 VVAFIVA-GSPEVVLKRHNI------DMEKVEK-IREALKKGDFGTAFGTVDDAMLEAFS 281 Query 327 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAV 368 GTP+EV+++ + + G+ +V GS + P K + + Sbjct 282 IYGTPEEVVEKCKKLLEIGVTQIVA--GSPIGPDKEKAIKLI 321 >gi|15669729|ref|NP_248542.1| methylenetetrahydromethanopterin reductase [Methanocaldococcus jannaschii DSM 2661] gi|38604646|sp|Q58929.2|MER_METJA RecName: Full=5,10-methylenetetrahydromethanopterin reductase; AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase; AltName: Full=Methylene-H(4)MPT reductase gi|2826429|gb|AAB99555.1| N5,N10-methylene-tetrahydromethanopterin reductase (mer) [Methanocaldococcus jannaschii DSM 2661] Length=331 Score = 113 bits (282), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 88/294 (30%), Positives = 140/294 (48%), Gaps = 16/294 (5%) Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 ++++LG VT+ R+PA+TA A ATL L+ GRA+LGIG G++ + G+EW KPV Sbjct 54 NKIKLGPGVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTT 113 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 +E++ IR L GE +S E + A + P + P +++ A GP+ML G Sbjct 114 LKESIEVIRKLL--AGERVSYEGKVVKIAGAALAVKPIQKAVP-VYMGAQGPKMLETAGM 170 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 266 AD + I P D+ A+ ++ A AGR I AA + +N D ++A Sbjct 171 IADGVL-INASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVP 229 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 326 VV A G P RHG+ D V+ I + V +++ Sbjct 230 VVA-FIAAGSPPVVLERHGI------DMEKVE-AIRNALKSGNFPEAFKNVDDTMLEAFS 281 Query 327 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKK 380 GTP++V+++ + + G+ +V GS + P+ K L KV+ LK+ Sbjct 282 IYGTPEDVVEKCKKLAEMGVTQIVA--GSPIGPN--KETAIKLIGKKVIPALKE 331 >gi|2129143|pir||E64491 N5,N10-methylenetetrahydromethanopterin dehydrogenase (coenzyme F420-dependent) (EC 1.-.-.-) - Methanococcus jannaschii Length=342 Score = 112 bits (281), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 88/294 (30%), Positives = 140/294 (48%), Gaps = 16/294 (5%) Query 87 SRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAILGIGVGEREGNEPYGVEWTKPVAR 146 ++++LG VT+ R+PA+TA A ATL L+ GRA+LGIG G++ + G+EW KPV Sbjct 65 NKIKLGPGVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTT 124 Query 147 FEEALATIRALWNSNGELISRESPYFPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGR 206 +E++ IR L GE +S E + A + P + P +++ A GP+ML G Sbjct 125 LKESIEVIRKLL--AGERVSYEGKVVKIAGAALAVKPIQKAVP-VYMGAQGPKMLETAGM 181 Query 207 YADAWIPIVVVRPSDYSRALEAVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALES 266 AD + I P D+ A+ ++ A AGR I AA + +N D ++A Sbjct 182 IADGVL-INASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVP 240 Query 267 VVVKMTALGVPGEAWARHGVEHPMGADFSGVQDIIPQTMDKQTVLSYAAKVPAALMKEVV 326 VV A G P RHG+ D V+ I + V +++ Sbjct 241 VVA-FIAAGSPPVVLERHGI------DMEKVE-AIRNALKSGNFPEAFKNVDDTMLEAFS 292 Query 327 FSGTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLRKTVTAVLPHAKVLRGLKK 380 GTP++V+++ + + G+ +V GS + P+ K L KV+ LK+ Sbjct 293 IYGTPEDVVEKCKKLAEMGVTQIVA--GSPIGPN--KETAIKLIGKKVIPALKE 342 Lambda K H 0.319 0.135 0.413 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 737398932000 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40