BLAST Search Results

BLASTP 2.2.25+ Reference: Stephen F. Altschul, Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Alejandro A. Schäffer, L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 15,229,318 sequences; 5,219,829,388 total letters Query= Rv3015c Length=337 Score E Sequences producing significant alignments: (Bits) Value gi|15610152|ref|NP_217531.1| hypothetical protein Rv3015c [Mycob... 638 0.0 gi|289746821|ref|ZP_06506199.1| conserved hypothetical protein [... 634 7e-180 gi|289444581|ref|ZP_06434325.1| LOW QUALITY PROTEIN: methionine ... 628 3e-178 gi|240168923|ref|ZP_04747582.1| hypothetical protein MkanA1_0640... 520 1e-145 gi|183981706|ref|YP_001849997.1| hypothetical protein MMAR_1692 ... 511 5e-143 gi|118617525|ref|YP_905857.1| hypothetical protein MUL_1930 [Myc... 507 1e-141 gi|296171258|ref|ZP_06852662.1| vitamin-B12 independent methioni... 490 1e-136 gi|41409153|ref|NP_961989.1| hypothetical protein MAP3055c [Myco... 482 3e-134 gi|15827912|ref|NP_302175.1| hypothetical protein ML1706 [Mycoba... 481 7e-134 gi|254820451|ref|ZP_05225452.1| methionine synthase, vitamin-B12... 481 7e-134 gi|336459168|gb|EGO38115.1| methionine synthase II (cobalamin-in... 480 2e-133 gi|118472619|ref|YP_886702.1| methionine synthase, vitamin-B12 i... 457 1e-126 gi|342858156|ref|ZP_08714811.1| methionine synthase, vitamin-B12... 454 1e-125 gi|126434446|ref|YP_001070137.1| methionine synthase, vitamin-B1... 439 4e-121 gi|145224831|ref|YP_001135509.1| methionine synthase, vitamin-B1... 431 6e-119 gi|333991379|ref|YP_004523993.1| hypothetical protein JDM601_273... 430 2e-118 gi|120403100|ref|YP_952929.1| methionine synthase, vitamin-B12 i... 429 4e-118 gi|108798846|ref|YP_639043.1| methionine synthase, vitamin-B12 i... 428 5e-118 gi|119867961|ref|YP_937913.1| methionine synthase, vitamin-B12 i... 427 1e-117 gi|2414535|emb|CAB16424.1| hypothetical protein MLCB637.09 [Myco... 412 3e-113 gi|169630433|ref|YP_001704082.1| putative methionine synthase, v... 368 9e-100 gi|325675869|ref|ZP_08155553.1| vitamin-B12 independent methioni... 320 2e-85 gi|312140512|ref|YP_004007848.1| methionine synthase [Rhodococcu... 317 1e-84 gi|226305866|ref|YP_002765826.1| hypothetical protein RER_23790 ... 305 5e-81 gi|226365930|ref|YP_002783713.1| hypothetical protein ROP_65210 ... 304 1e-80 gi|111023429|ref|YP_706401.1| hypothetical protein RHA1_ro06468 ... 304 2e-80 gi|54026237|ref|YP_120479.1| hypothetical protein nfa42660 [Noca... 303 2e-80 gi|333920879|ref|YP_004494460.1| hypothetical protein AS9A_3215 ... 301 1e-79 gi|229493393|ref|ZP_04387182.1| methionine synthase, vitamin-B12... 299 4e-79 gi|326381519|ref|ZP_08203213.1| methionine synthase vitamin-B12 ... 264 1e-68 gi|343926873|ref|ZP_08766366.1| hypothetical protein GOALK_072_0... 261 1e-67 gi|302524938|ref|ZP_07277280.1| methionine synthase [Streptomyce... 258 1e-66 gi|257054922|ref|YP_003132754.1| cobalamin-independent methionin... 248 1e-63 gi|331695632|ref|YP_004331871.1| methionine synthase vitamin-B12... 238 1e-60 gi|262203143|ref|YP_003274351.1| methionine synthase vitamin-B12... 236 5e-60 gi|296140602|ref|YP_003647845.1| methionine synthase vitamin-B12... 233 5e-59 gi|300783589|ref|YP_003763880.1| vitamin-B12 independent methion... 229 3e-58 gi|337768307|emb|CCB77020.1| conserved protein of unknown functi... 229 6e-58 gi|134102619|ref|YP_001108280.1| methionine synthase, vitamin-B1... 228 1e-57 gi|269127768|ref|YP_003301138.1| methionine synthase vitamin-B12... 222 8e-56 gi|345002207|ref|YP_004805061.1| methionine synthase vitamin-B12... 221 2e-55 gi|302537076|ref|ZP_07289418.1| methionine synthase vitamin-B12 ... 218 9e-55 gi|302542308|ref|ZP_07294650.1| methionine synthase, vitamin-B12... 217 2e-54 gi|297191910|ref|ZP_06909308.1| methionine synthase [Streptomyce... 217 2e-54 gi|271969280|ref|YP_003343476.1| hypothetical protein Sros_8078 ... 216 3e-54 gi|325003019|ref|ZP_08124131.1| cobalamin-independent methionine... 216 4e-54 gi|238063189|ref|ZP_04607898.1| methionine synthase, vitamin-B12... 216 5e-54 gi|297156987|gb|ADI06699.1| hypothetical protein SBI_03578 [Stre... 215 8e-54 gi|254383200|ref|ZP_04998553.1| conserved hypothetical protein [... 215 9e-54 gi|345009511|ref|YP_004811865.1| methionine synthase vitamin-B12... 214 1e-53 >gi|15610152|ref|NP_217531.1| hypothetical protein Rv3015c [Mycobacterium tuberculosis H37Rv] gi|15842573|ref|NP_337610.1| hypothetical protein MT3095 [Mycobacterium tuberculosis CDC1551] gi|31794192|ref|NP_856685.1| hypothetical protein Mb3040c [Mycobacterium bovis AF2122/97] 63 more sequence titles Length=337 Score = 638 bits (1645), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/337 (99%), Positives = 337/337 (100%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA Sbjct 1 MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA Sbjct 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL Sbjct 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST Sbjct 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL Sbjct 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI Sbjct 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 >gi|289746821|ref|ZP_06506199.1| conserved hypothetical protein [Mycobacterium tuberculosis 02_1987] gi|289759141|ref|ZP_06518519.1| vitamin-B12 independent methionine synthase [Mycobacterium tuberculosis T85] gi|294993894|ref|ZP_06799585.1| hypothetical protein Mtub2_05103 [Mycobacterium tuberculosis 210] gi|289687349|gb|EFD54837.1| conserved hypothetical protein [Mycobacterium tuberculosis 02_1987] gi|289714705|gb|EFD78717.1| vitamin-B12 independent methionine synthase [Mycobacterium tuberculosis T85] gi|326904629|gb|EGE51562.1| hypothetical protein TBPG_02537 [Mycobacterium tuberculosis W-148] gi|339295849|gb|AEJ47960.1| hypothetical protein CCDC5079_2770 [Mycobacterium tuberculosis CCDC5079] gi|339299461|gb|AEJ51571.1| hypothetical protein CCDC5180_2734 [Mycobacterium tuberculosis CCDC5180] Length=337 Score = 634 bits (1635), Expect = 7e-180, Method: Compositional matrix adjust. Identities = 335/337 (99%), Positives = 336/337 (99%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA Sbjct 1 MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA Sbjct 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQ DEPSLPAALGGRL Sbjct 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQCDEPSLPAALGGRL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST Sbjct 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL Sbjct 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI Sbjct 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 >gi|289444581|ref|ZP_06434325.1| LOW QUALITY PROTEIN: methionine synthase, vitamin-B12 independent protein [Mycobacterium tuberculosis T46] gi|289417500|gb|EFD14740.1| LOW QUALITY PROTEIN: methionine synthase, vitamin-B12 independent protein [Mycobacterium tuberculosis T46] Length=338 Score = 628 bits (1620), Expect = 3e-178, Method: Compositional matrix adjust. Identities = 332/334 (99%), Positives = 333/334 (99%), Gaps = 0/334 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA Sbjct 1 MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA Sbjct 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL Sbjct 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST Sbjct 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL Sbjct 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDP 334 GVSPACGLANATGQWARTAVGLARDVAEAFAR P Sbjct 301 GVSPACGLANATGQWARTAVGLARDVAEAFARGP 334 >gi|240168923|ref|ZP_04747582.1| hypothetical protein MkanA1_06400 [Mycobacterium kansasii ATCC 12478] Length=341 Score = 520 bits (1339), Expect = 1e-145, Method: Compositional matrix adjust. Identities = 275/334 (83%), Positives = 295/334 (89%), Gaps = 0/334 (0%) Query 4 FATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDT 63 FA ATGIGSWPGTAAR AA+VVVGELA ALA+L ELPARGVGADMLGRAG LL+D+A+DT Sbjct 8 FARATGIGSWPGTAARPAAEVVVGELADALAHLVELPARGVGADMLGRAGALLLDLAVDT 67 Query 64 VPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLE 123 VPRGYRI ARPG VTRRA SLL+EDMDALEEAWETAGLRG G+ VKVQAPGP+TL AGLE Sbjct 68 VPRGYRIVARPGTVTRRAVSLLNEDMDALEEAWETAGLRGSGQVVKVQAPGPITLSAGLE 127 Query 124 LANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGV 183 LANGHRAITDPGAVRDLAASLAEGVAAHRA LARRLDTPVVVQFDEPSLPAALGGRLTGV Sbjct 128 LANGHRAITDPGAVRDLAASLAEGVAAHRATLARRLDTPVVVQFDEPSLPAALGGRLTGV 187 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 TAL+PVAPLDE VA ALLDTC A ADV +HSC+P+LPW+LL+RS I AVSVDA TL A Sbjct 188 TALTPVAPLDEAVAGALLDTCAEAAGADVMVHSCAPELPWELLRRSAIGAVSVDAGTLCA 247 Query 244 ADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVS 303 ADLD VAAFVE+GRTVVLG+VP AP R P+ EEVA VAVTDRLG RSALRDR+GVS Sbjct 248 ADLDGVAAFVETGRTVVLGVVPAVAPLRRPAAEEVAGQVVAVTDRLGFSRSALRDRVGVS 307 Query 304 PACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 PACGLA AT QWARTA+GLAR AEAFA DP+AI Sbjct 308 PACGLAGATPQWARTAIGLARKAAEAFAEDPDAI 341 >gi|183981706|ref|YP_001849997.1| hypothetical protein MMAR_1692 [Mycobacterium marinum M] gi|183175032|gb|ACC40142.1| conserved hypothetical protein [Mycobacterium marinum M] Length=337 Score = 511 bits (1317), Expect = 5e-143, Method: Compositional matrix adjust. Identities = 266/337 (79%), Positives = 296/337 (88%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATATG+GSWPG AR AA+VVVGELA ALAYL ELPARGVGADMLGRAG LLVD+A Sbjct 1 MSVFATATGVGSWPGILARPAAEVVVGELADALAYLVELPARGVGADMLGRAGALLVDLA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 +DTVPRGYRI +RPGAVTRRA S+L+EDMDALEEAWETAGLRG GR VKVQAPGP+TL A Sbjct 61 LDTVPRGYRIVSRPGAVTRRAISMLNEDMDALEEAWETAGLRGGGRVVKVQAPGPITLAA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 G+EL+NGHRAITDPGAVRDLAASL EGVAAHRA LARRLDTPVVVQFDEP+LPAAL GRL Sbjct 121 GVELSNGHRAITDPGAVRDLAASLGEGVAAHRAELARRLDTPVVVQFDEPTLPAALEGRL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVT+L+PVA LDE VA LLDTC+ A ADVALHSC+ LPWDLLQRS ISAVSVD +T Sbjct 181 TGVTSLAPVAALDEAVALGLLDTCVEAAGADVALHSCAAALPWDLLQRSGISAVSVDVAT 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L+AADLD++AAF++SGRTVVLG+VP + P+R PS EEVAA VAVTDRLG R+ LRDR+ Sbjct 241 LRAADLDSIAAFIDSGRTVVLGVVPASVPDRRPSAEEVAADVVAVTDRLGFGRTVLRDRV 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+P CGLA AT QWARTA+GLAR AE ARDP+AI Sbjct 301 GVAPGCGLAGATPQWARTAIGLARKAAEGLARDPDAI 337 >gi|118617525|ref|YP_905857.1| hypothetical protein MUL_1930 [Mycobacterium ulcerans Agy99] gi|118569635|gb|ABL04386.1| conserved hypothetical protein [Mycobacterium ulcerans Agy99] Length=337 Score = 507 bits (1305), Expect = 1e-141, Method: Compositional matrix adjust. Identities = 264/337 (79%), Positives = 294/337 (88%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATATG+GSWPG AR AA+VVVGELA ALAYL ELPARGVGADMLGRAG LLVD+A Sbjct 1 MSVFATATGVGSWPGILARPAAEVVVGELADALAYLVELPARGVGADMLGRAGALLVDLA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 +DTVPRGYRI RPGAVTRRA S+L+EDMDALEEAWETAGLRG GR VKVQAPGP+TL A Sbjct 61 LDTVPRGYRIVPRPGAVTRRAISMLNEDMDALEEAWETAGLRGGGRVVKVQAPGPITLAA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 G+EL+NGHRAI DPGAVRDLAASL EGVAAHRA LARRLDTPVVVQFDEP+LPAAL GRL Sbjct 121 GVELSNGHRAIIDPGAVRDLAASLGEGVAAHRAELARRLDTPVVVQFDEPTLPAALEGRL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVT+L+PVA LDE VA LLDTC+ A ADVALHSC+ LPWDLLQRS ISAVSVD +T Sbjct 181 TGVTSLAPVAALDEAVALGLLDTCVEAAGADVALHSCAAALPWDLLQRSGISAVSVDVAT 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L+AADLD++AAF++SGRTVVLG+VP + P+R PS EEVAA VAVTDRLG R+ LRD + Sbjct 241 LRAADLDSIAAFIDSGRTVVLGVVPASVPDRRPSAEEVAADVVAVTDRLGFGRTVLRDHV 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+P CGLA AT QWARTA+GLAR+ AE ARDP+AI Sbjct 301 GVAPGCGLAGATPQWARTAIGLAREAAEGLARDPDAI 337 >gi|296171258|ref|ZP_06852662.1| vitamin-B12 independent methionine synthase [Mycobacterium parascrofulaceum ATCC BAA-614] gi|295894226|gb|EFG73983.1| vitamin-B12 independent methionine synthase [Mycobacterium parascrofulaceum ATCC BAA-614] Length=337 Score = 490 bits (1261), Expect = 1e-136, Method: Compositional matrix adjust. Identities = 268/337 (80%), Positives = 295/337 (88%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFA A+G+GSWPG+ REAA+VVVGELAGALA++ ELPARGVGADMLGRAG LL+DVA Sbjct 1 MSVFARASGVGSWPGSRPREAAEVVVGELAGALAHIVELPARGVGADMLGRAGALLIDVA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYR+AARPGA+TRRA SLLDEDMDALEEAWE AGLRG R VKVQAPGP+TL A Sbjct 61 IDTVPRGYRVAARPGAITRRAVSLLDEDMDALEEAWEVAGLRGGDRVVKVQAPGPITLAA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 GLELANGHRAITD GAVRDLAASLAEGVAAHRAALARRL TPVVVQFDEPSLP ALGGRL Sbjct 121 GLELANGHRAITDSGAVRDLAASLAEGVAAHRAALARRLRTPVVVQFDEPSLPMALGGRL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTALSPVAP+DE VA LLD C+A V +V +HSC+PDLPW +LQ S SAVSVD+ST Sbjct 181 TGVTALSPVAPIDEAVAVGLLDACVATVGGEVLVHSCAPDLPWKVLQDSSFSAVSVDSST 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L AADLD VAAFVESGR V+LG+VP +AP+R PS EEVA A VAVTDRLG RSALRDR+ Sbjct 241 LVAADLDGVAAFVESGRAVMLGVVPGSAPQRRPSTEEVAGALVAVTDRLGFGRSALRDRI 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+PACGLA AT +WARTA+ LAR AEAFA DP+AI Sbjct 301 GVTPACGLAGATPEWARTAIELARTAAEAFAEDPDAI 337 >gi|41409153|ref|NP_961989.1| hypothetical protein MAP3055c [Mycobacterium avium subsp. paratuberculosis K-10] gi|118465803|ref|YP_883032.1| methionine synthase, vitamin-B12 independent, putative [Mycobacterium avium 104] gi|254776289|ref|ZP_05217805.1| methionine synthase, vitamin-B12 independent, putative [Mycobacterium avium subsp. avium ATCC 25291] gi|41397973|gb|AAS05603.1| hypothetical protein MAP_3055c [Mycobacterium avium subsp. paratuberculosis K-10] gi|118167090|gb|ABK67987.1| methionine synthase, vitamin-B12 independent, putative [Mycobacterium avium 104] Length=342 Score = 482 bits (1241), Expect = 3e-134, Method: Compositional matrix adjust. Identities = 260/334 (78%), Positives = 283/334 (85%), Gaps = 0/334 (0%) Query 4 FATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDT 63 FATA+G+GSWPGT AREAA+VVVGELAGALA++ ELPARGVGADMLGRAG LLVDVAIDT Sbjct 8 FATASGVGSWPGTVAREAAEVVVGELAGALAHIVELPARGVGADMLGRAGALLVDVAIDT 67 Query 64 VPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLE 123 VPRGYR+ ARPGAVTRRA SLLDEDMDALEEAWE AGLR GR VKVQAPGPVTL A +E Sbjct 68 VPRGYRLVARPGAVTRRAISLLDEDMDALEEAWEAAGLRNDGRVVKVQAPGPVTLAAEIE 127 Query 124 LANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGV 183 LANGHRAITDPGA+RDLAASL EGVAAHRA L+RRL+TPVVVQFDEPSLPAALGG L GV Sbjct 128 LANGHRAITDPGALRDLAASLGEGVAAHRARLSRRLETPVVVQFDEPSLPAALGGGLPGV 187 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 TALSPV PLDE +A LLD C+ V +V LH C PD+PW+LLQ S SAVSVDAS L A Sbjct 188 TALSPVPPLDEALARGLLDGCVHTVGGEVLLHCCGPDMPWNLLQDSAFSAVSVDASALGA 247 Query 244 ADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVS 303 ADLD +AAFVESGR V LG+V V P R PS E+VA A VAVTDRLG RSALRDR+GV+ Sbjct 248 ADLDGMAAFVESGRAVALGVVAVGVPPRRPSAEQVAGAVVAVTDRLGFTRSALRDRIGVT 307 Query 304 PACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 PACGLA AT +WARTA+GLAR AE FA DP+AI Sbjct 308 PACGLAGATPEWARTAIGLARRAAELFAEDPDAI 341 >gi|15827912|ref|NP_302175.1| hypothetical protein ML1706 [Mycobacterium leprae TN] gi|221230389|ref|YP_002503805.1| hypothetical protein MLBr_01706 [Mycobacterium leprae Br4923] gi|13093465|emb|CAC30659.1| conserved hypothetical protein [Mycobacterium leprae] gi|219933496|emb|CAR71801.1| conserved hypothetical protein [Mycobacterium leprae Br4923] Length=337 Score = 481 bits (1238), Expect = 7e-134, Method: Compositional matrix adjust. Identities = 263/337 (79%), Positives = 290/337 (87%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATA+G+GSWPG++ AA+VVVGELAGALA++ ELPARGVGADMLGRAG LL+DVA Sbjct 1 MSVFATASGVGSWPGSSPYPAAKVVVGELAGALAHIVELPARGVGADMLGRAGALLIDVA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIAARPGAVTRRA SLLDEDMDA E AWE AGLRG GR VKVQAPGP+TL A Sbjct 61 IDTVPRGYRIAARPGAVTRRAFSLLDEDMDAFEAAWEMAGLRGRGRVVKVQAPGPITLAA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 GLELANGHRAITD AVRDLA SLAEGVAAHRAALARRLDT VVVQFDE SLPAALGG L Sbjct 121 GLELANGHRAITDSCAVRDLAESLAEGVAAHRAALARRLDTQVVVQFDEVSLPAALGGLL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTA SPVAPLDET+A L D+C+A V ADV LHSC+ +LPW+ LQRS I AVSVD + Sbjct 181 TGVTAFSPVAPLDETLAATLFDSCVATVGADVLLHSCAAELPWNFLQRSAIRAVSVDVNV 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L+ DLD +AAFVESGRTVVLG+VP TAP+R PS+E+VAAA V VTDRLG RSALRDR+ Sbjct 241 LRTGDLDGIAAFVESGRTVVLGVVPATAPQRLPSVEQVAAAVVGVTDRLGFGRSALRDRI 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GVSPACGLA AT WA TA+ LAR AEAFA+DP+AI Sbjct 301 GVSPACGLAGATPHWACTAIELARKTAEAFAQDPDAI 337 >gi|254820451|ref|ZP_05225452.1| methionine synthase, vitamin-B12 independent, putative [Mycobacterium intracellulare ATCC 13950] Length=338 Score = 481 bits (1238), Expect = 7e-134, Method: Compositional matrix adjust. Identities = 252/337 (75%), Positives = 280/337 (84%), Gaps = 0/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFA +G+GSWPG AAREAA V+VGELAGAL ++ ELPARGVGAD+LGRAG LLVDVA Sbjct 1 MSVFAGPSGVGSWPGIAAREAAAVIVGELAGALPHIVELPARGVGADLLGRAGALLVDVA 60 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYR+ ARPGAV+RRA SLLDEDMDALEEAWE AGLR GR VKVQAPGP+TL A Sbjct 61 IDTVPRGYRLVARPGAVSRRAISLLDEDMDALEEAWEAAGLRNDGRVVKVQAPGPITLAA 120 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 +ELANGHRAITDPGA+RDL +SLAEGVAAHRA L+RRL+TPVVVQFDEPSLP ALGG L Sbjct 121 EIELANGHRAITDPGALRDLTSSLAEGVAAHRAQLSRRLETPVVVQFDEPSLPKALGGAL 180 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 +GVTALSPVAPLDE VA LLD C V +VALH C+P +PWDLLQRS SAVSVD Sbjct 181 SGVTALSPVAPLDEAVAGGLLDACAETVGGEVALHCCAPGVPWDLLQRSAFSAVSVDPGA 240 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L AADLD +AAFVES R VVLG+VP +AP R S EEVA VAVTDRLG RSALR+R+ Sbjct 241 LSAADLDGIAAFVESDRAVVLGVVPASAPARRLSAEEVAGGVVAVTDRLGFARSALRERI 300 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+PACGLA AT WARTA+ LAR A+ FA DP+AI Sbjct 301 GVTPACGLAGATPAWARTAIELARKAAQMFAEDPDAI 337 >gi|336459168|gb|EGO38115.1| methionine synthase II (cobalamin-independent) [Mycobacterium avium subsp. paratuberculosis S397] Length=342 Score = 480 bits (1235), Expect = 2e-133, Method: Compositional matrix adjust. Identities = 259/334 (78%), Positives = 282/334 (85%), Gaps = 0/334 (0%) Query 4 FATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDT 63 FATA+G+GSWPGT AREAA+VVVGELAGALA++ ELPARGVGADMLGRAG LLVDVAIDT Sbjct 8 FATASGVGSWPGTVAREAAEVVVGELAGALAHIVELPARGVGADMLGRAGALLVDVAIDT 67 Query 64 VPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLE 123 VPRGYR+ ARPGAV RRA SLLDEDMDALEEAWE AGLR GR VKVQAPGPVTL A +E Sbjct 68 VPRGYRLVARPGAVIRRAISLLDEDMDALEEAWEAAGLRNDGRVVKVQAPGPVTLAAEIE 127 Query 124 LANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGV 183 LANGHRAITDPGA+RDLAASL EGVAAHRA L+RRL+TPVVVQFDEPSLPAALGG L GV Sbjct 128 LANGHRAITDPGALRDLAASLGEGVAAHRARLSRRLETPVVVQFDEPSLPAALGGGLPGV 187 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 TALSPV PLDE +A LLD C+ V +V LH C PD+PW+LLQ S SAVSVDAS L A Sbjct 188 TALSPVPPLDEALARGLLDGCVHTVGGEVLLHCCGPDMPWNLLQDSAFSAVSVDASALGA 247 Query 244 ADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVS 303 ADLD +AAFVESGR V LG+V V P R PS E+VA A VAVTDRLG RSALRDR+GV+ Sbjct 248 ADLDGMAAFVESGRAVALGVVAVGVPPRRPSAEQVAGAVVAVTDRLGFTRSALRDRIGVT 307 Query 304 PACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 PACGLA AT +WARTA+GLAR AE FA DP+AI Sbjct 308 PACGLAGATPEWARTAIGLARRAAELFAEDPDAI 341 >gi|118472619|ref|YP_886702.1| methionine synthase, vitamin-B12 independent [Mycobacterium smegmatis str. MC2 155] gi|118173906|gb|ABK74802.1| methionine synthase, vitamin-B12 independent [Mycobacterium smegmatis str. MC2 155] Length=336 Score = 457 bits (1176), Expect = 1e-126, Method: Compositional matrix adjust. Identities = 232/337 (69%), Positives = 278/337 (83%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +S+FATATG+GSWPGT AR+AA++VVGEL L++L ELPARG+GAD++GRAG LLVD+ Sbjct 1 MSIFATATGVGSWPGTTARQAAEIVVGELH-TLSHLVELPARGIGADLIGRAGALLVDIG 59 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIA + RRA SLL ED+DALEEAWE AGLRG GR VK+QAPGPVTL A Sbjct 60 IDTVPRGYRIAPGRSSALRRAVSLLGEDLDALEEAWEKAGLRGSGRPVKLQAPGPVTLAA 119 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL GHRAITDPGA+RDL ASLAEGVAAHRA +ARRL+T VVVQFDEPSLPAAL GRL Sbjct 120 HLELPGGHRAITDPGALRDLGASLAEGVAAHRAEVARRLETTVVVQFDEPSLPAALQGRL 179 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 +GVT+L+PV P+DE +A +LLD C+A D +VA+HSC+ DLPW L RS I A+SVD ST Sbjct 180 SGVTSLTPVHPVDEPLAMSLLDACVAQADTEVAVHSCAADLPWKALLRSNIHAISVDVST 239 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L AADLD V FV++GRTV+LG+VP +AP R P++EE+A + VAVTDRLG R LR+R+ Sbjct 240 LTAADLDGVGEFVDAGRTVLLGVVPTSAPNRRPAVEEIAKSVVAVTDRLGFAREVLRERI 299 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+PACGLA AT +WARTA+ LA+ VA+ FA+DPE I Sbjct 300 GVTPACGLAGATPEWARTAIELAQKVADGFAQDPEGI 336 >gi|342858156|ref|ZP_08714811.1| methionine synthase, vitamin-B12 independent [Mycobacterium colombiense CECT 3035] gi|342133860|gb|EGT87040.1| methionine synthase, vitamin-B12 independent [Mycobacterium colombiense CECT 3035] Length=342 Score = 454 bits (1168), Expect = 1e-125, Method: Compositional matrix adjust. Identities = 256/334 (77%), Positives = 281/334 (85%), Gaps = 0/334 (0%) Query 4 FATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDT 63 FATA+G+GSWPG AAR+AA+VVVGELAGALA++ ELPARGVGADMLGRAG LL+DVAIDT Sbjct 8 FATASGVGSWPGIAARQAAEVVVGELAGALAHIVELPARGVGADMLGRAGALLIDVAIDT 67 Query 64 VPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLE 123 VPRGYR+AARPGAVTRRA SLLDEDMDALEEAWE AGLR GR VKVQAPGP+TL A +E Sbjct 68 VPRGYRLAARPGAVTRRAVSLLDEDMDALEEAWEAAGLRNDGRVVKVQAPGPITLAAEIE 127 Query 124 LANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGV 183 L+NGHRAITDPGA+RDLAASLAEGV+AHRA LARRL+ VVVQFDEPSLP ALGG L+GV Sbjct 128 LSNGHRAITDPGALRDLAASLAEGVSAHRAGLARRLEAEVVVQFDEPSLPKALGGALSGV 187 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 TALSPVAP+DE VA LLD C V + LH C+P LPWDLLQRS AVSVDA+ L A Sbjct 188 TALSPVAPIDEEVAAGLLDACARTVGGEALLHCCAPGLPWDLLQRSAFRAVSVDAAALSA 247 Query 244 ADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVS 303 ADLD VA FVESGRTV LG+V P R PS EEVAAA VAVTDRLG RSALRDR+GV+ Sbjct 248 ADLDGVAEFVESGRTVALGVVAGNPPPRRPSAEEVAAAVVAVTDRLGFARSALRDRIGVT 307 Query 304 PACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 PACGLA AT +WARTA+ LAR AE FA DP+AI Sbjct 308 PACGLAGATPEWARTAIELARKAAEMFAEDPDAI 341 >gi|126434446|ref|YP_001070137.1| methionine synthase, vitamin-B12 independent [Mycobacterium sp. JLS] gi|126234246|gb|ABN97646.1| Methionine synthase, vitamin-B12 independent [Mycobacterium sp. JLS] Length=336 Score = 439 bits (1128), Expect = 4e-121, Method: Compositional matrix adjust. Identities = 229/337 (68%), Positives = 271/337 (81%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 ++V+A ATGIGSWPG R+AA++VVGEL L +L ELP+RGVGADM+GRAG LLVD+ Sbjct 1 MTVYAAATGIGSWPGANPRQAAEIVVGELH-TLPHLVELPSRGVGADMIGRAGALLVDIG 59 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 ID VPRGYRIA + RRA SLL+ED+DALEEAWE +GLRG GR VKVQAPGP+TL A Sbjct 60 IDIVPRGYRIAHGRSSAVRRARSLLEEDVDALEEAWEKSGLRGSGRTVKVQAPGPITLAA 119 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL GHRA+TD GAVRDLAASLAEG+A HRA ++RRLDTPVVVQFDEP LPAAL GRL Sbjct 120 ELELPGGHRALTDRGAVRDLAASLAEGMAVHRAEVSRRLDTPVVVQFDEPLLPAALAGRL 179 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTA +PV P+DE VA LLD CIA V +VALHSC+ LPW LL RSR+ AV+VDA T Sbjct 180 TGVTAFTPVHPVDEAVATQLLDECIARVGGEVALHSCAVGLPWKLLLRSRLQAVAVDAVT 239 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L A DLD + FVESGRTV+LG+VP AP PS+E+VAAAAV++TDRLG PR+ LR+R+ Sbjct 240 LTAEDLDGIGEFVESGRTVLLGVVPGAAPAARPSVEQVAAAAVSLTDRLGFPRAVLRERI 299 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+PACGLA AT +WAR AV L + A+AFA +P+A+ Sbjct 300 GVTPACGLATATPEWARRAVELTQKTADAFADEPDAL 336 >gi|145224831|ref|YP_001135509.1| methionine synthase, vitamin-B12 independent [Mycobacterium gilvum PYR-GCK] gi|315445162|ref|YP_004078041.1| cobalamin-independent methionine synthase [Mycobacterium sp. Spyr1] gi|145217317|gb|ABP46721.1| Methionine synthase, vitamin-B12 independent [Mycobacterium gilvum PYR-GCK] gi|315263465|gb|ADU00207.1| cobalamin-independent methionine synthase [Mycobacterium sp. Spyr1] Length=336 Score = 431 bits (1109), Expect = 6e-119, Method: Compositional matrix adjust. Identities = 239/337 (71%), Positives = 274/337 (82%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFATATG+GSWPGT+A+EAA+VVVGEL L +L ELPARG+GADM+GRAGGLLVD+ Sbjct 1 MSVFATATGVGSWPGTSAKEAAEVVVGELH-RLPHLVELPARGLGADMIGRAGGLLVDIW 59 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIA+ +VTRRA SLL+ED+DALEEAWE AGLRG GRAVKVQAPGPVTL A Sbjct 60 IDTVPRGYRIASGRSSVTRRAVSLLEEDLDALEEAWEKAGLRGGGRAVKVQAPGPVTLAA 119 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL GHRAITDPGAVRDL ASLAEGVAAHRAALARRL++PVVVQFDEP+LPAAL GRL Sbjct 120 QLELPGGHRAITDPGAVRDLTASLAEGVAAHRAALARRLESPVVVQFDEPTLPAALAGRL 179 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVT+LSPV P+D+ VA ALLD C+ V DV +H C+ +PW LLQRS + AVSVD T Sbjct 180 TGVTSLSPVHPVDDAVATALLDDCVQTVGGDVVVHCCASGVPWKLLQRSAVHAVSVDVDT 239 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L A DLD V FV+SGRTVVLG VP AP PS E++AA AVTDRLG R+ LRDR+ Sbjct 240 LSADDLDGVGEFVDSGRTVVLGAVPTAAPAARPSAEQIAATVAAVTDRLGFARAVLRDRV 299 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 G++PACGLA AT WAR+A+ LA+ A+ A DPEA Sbjct 300 GITPACGLAGATTAWARSAIELAQRAADGLADDPEAF 336 >gi|333991379|ref|YP_004523993.1| hypothetical protein JDM601_2739 [Mycobacterium sp. JDM601] gi|333487347|gb|AEF36739.1| conserved hypothetical protein [Mycobacterium sp. JDM601] Length=334 Score = 430 bits (1105), Expect = 2e-118, Method: Compositional matrix adjust. Identities = 225/333 (68%), Positives = 264/333 (80%), Gaps = 1/333 (0%) Query 5 ATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTV 64 A AT IGSWPG++AR+AA+VVVGEL +LA+L ELPARGVGAD++GR+G LLVD+AIDT Sbjct 3 AFATAIGSWPGSSARQAAEVVVGELGASLAHLVELPARGVGADLIGRSGALLVDIAIDTA 62 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 PRGYR+AARPGAVTRRA SLL ED DALEEAWE GLRG G VKVQAPGP+TL A LEL Sbjct 63 PRGYRLAARPGAVTRRAISLLGEDTDALEEAWEIGGLRGSGHPVKVQAPGPLTLAAQLEL 122 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVT 184 NGHRAITDPGA+RDLA SL EG+ AHRA L RRLDT VVVQ DEP+L AA+ GRL GVT Sbjct 123 GNGHRAITDPGALRDLAGSLGEGLRAHRAELCRRLDTQVVVQLDEPALTAAVTGRLAGVT 182 Query 185 ALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAA 244 +LSPV +DE VA ALLD C V +V +HSC+ +LPW++LQ SRI+AVS+D +T Sbjct 183 SLSPVPAIDEAVATALLDGCADTVGGEVIVHSCAAELPWNVLQSSRIAAVSLDCTT-TPV 241 Query 245 DLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSP 304 D D + AF+ESGRTVV GL+P P P++EE+AAAA A+TDR+G RS L +R+G+SP Sbjct 242 DYDGIGAFIESGRTVVFGLIPAVQPTPRPAVEEIAAAAAAITDRIGFARSVLAERVGISP 301 Query 305 ACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 CGLA AT QWARTA+GL R V EA A DPEAI Sbjct 302 VCGLAGATAQWARTAIGLVRQVGEALAGDPEAI 334 >gi|120403100|ref|YP_952929.1| methionine synthase, vitamin-B12 independent [Mycobacterium vanbaalenii PYR-1] gi|119955918|gb|ABM12923.1| Methionine synthase, vitamin-B12 independent [Mycobacterium vanbaalenii PYR-1] Length=336 Score = 429 bits (1102), Expect = 4e-118, Method: Compositional matrix adjust. Identities = 236/337 (71%), Positives = 266/337 (79%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +SVFA ATGIGSWPGT+AREAA+VV+GEL L +L ELPARGVGADM+GRAG LLVD++ Sbjct 1 MSVFAAATGIGSWPGTSAREAAEVVIGELH-RLPHLVELPARGVGADMIGRAGALLVDIS 59 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 IDTVPRGYRIA RRA SLL+ED+DALEEAWE AGLRG RAVKVQAPGPVTL A Sbjct 60 IDTVPRGYRIARGRSGAMRRAVSLLEEDLDALEEAWEKAGLRGGERAVKVQAPGPVTLAA 119 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL GHRAITD GAVRDL SLAEGVA HRA L RRL++PVVVQFDEPSLPAAL GRL Sbjct 120 QLELPGGHRAITDQGAVRDLTTSLAEGVAMHRAQLLRRLESPVVVQFDEPSLPAALAGRL 179 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVT +SPV P+DE+V ALLD C+ AV +VALHSC+ D+PW LLQRS ISAVSVD T Sbjct 180 TGVTGVSPVHPVDESVVPALLDECVEAVGGEVALHSCAADIPWKLLQRSAISAVSVDMHT 239 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L ADLD + FV+S RTV+LG VP P PS E++AAA VTDRLG PRS LRDR+ Sbjct 240 LTPADLDGIGEFVDSNRTVLLGAVPTADPGTRPSAEQIAAAVADVTDRLGFPRSVLRDRV 299 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 GV+PACGLA AT WAR AV LA+ A+ A DP+A+ Sbjct 300 GVTPACGLAAATQAWARAAVELAQRAADGLADDPDAV 336 >gi|108798846|ref|YP_639043.1| methionine synthase, vitamin-B12 independent [Mycobacterium sp. MCS] gi|108769265|gb|ABG07987.1| Methionine synthase, vitamin-B12 independent [Mycobacterium sp. MCS] Length=339 Score = 428 bits (1101), Expect = 5e-118, Method: Compositional matrix adjust. Identities = 224/325 (69%), Positives = 261/325 (81%), Gaps = 1/325 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 V+V+A ATGIGSWPG R+AA++VVGEL L +L ELP+RGVGADM+GRAG LLVD+ Sbjct 4 VTVYAAATGIGSWPGANPRQAAEIVVGELH-TLPHLVELPSRGVGADMIGRAGALLVDIG 62 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 ID VPRGYRIA + RRA SLL+ED+DALEEAWE +GLRG GR VKVQAPGP+TL A Sbjct 63 IDIVPRGYRIAHGRSSAVRRARSLLEEDVDALEEAWEKSGLRGSGRTVKVQAPGPITLAA 122 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL GHRA+TD GAVRDLAASLAEG+A HRA ++RRLDTPVVVQFDEP LPAAL GRL Sbjct 123 ELELPGGHRALTDRGAVRDLAASLAEGMAVHRAEVSRRLDTPVVVQFDEPLLPAALAGRL 182 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTA +PV P+DE VA LLD CIA V +VALHSC+ LPW LL RSR+ AV+VDA T Sbjct 183 TGVTAFTPVHPVDEAVATQLLDECIARVGGEVALHSCAVGLPWKLLLRSRLQAVAVDAVT 242 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L A DLD + FVESGRTV+LG+VP AP PS+E+VAAAAV++TDRLG PR+ LR+R+ Sbjct 243 LTAEDLDGIGEFVESGRTVLLGVVPGAAPAARPSVEQVAAAAVSLTDRLGFPRAVLRERI 302 Query 301 GVSPACGLANATGQWARTAVGLARD 325 GV+PACGLA AT +WAR AV L + Sbjct 303 GVTPACGLATATPEWARRAVELTQK 327 >gi|119867961|ref|YP_937913.1| methionine synthase, vitamin-B12 independent [Mycobacterium sp. KMS] gi|119694050|gb|ABL91123.1| Methionine synthase, vitamin-B12 independent [Mycobacterium sp. KMS] Length=336 Score = 427 bits (1098), Expect = 1e-117, Method: Compositional matrix adjust. Identities = 223/325 (69%), Positives = 261/325 (81%), Gaps = 1/325 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 ++V+A ATGIGSWPG R+AA++VVGEL L +L ELP+RGVGADM+GRAG LLVD+ Sbjct 1 MTVYAAATGIGSWPGANPRQAAEIVVGELH-TLPHLVELPSRGVGADMIGRAGALLVDIG 59 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 ID VPRGYRIA + RRA SLL+ED+DALEEAWE +GLRG GR VKVQAPGP+TL A Sbjct 60 IDIVPRGYRIAHGRSSAVRRARSLLEEDVDALEEAWEKSGLRGSGRTVKVQAPGPITLAA 119 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL GHRA+TD GAVRDLAASLAEG+A HRA ++RRLDTPVVVQFDEP LPAAL GRL Sbjct 120 ELELPGGHRALTDRGAVRDLAASLAEGMAVHRAEVSRRLDTPVVVQFDEPLLPAALAGRL 179 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 TGVTA +PV P+DE VA LLD CIA V +VALHSC+ LPW LL RSR+ AV+VDA T Sbjct 180 TGVTAFTPVHPVDEAVATQLLDECIARVGGEVALHSCAVGLPWKLLLRSRLQAVAVDAVT 239 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L A DLD + FVESGRTV+LG+VP AP PS+E+VAAAAV++TDRLG PR+ LR+R+ Sbjct 240 LTAEDLDGIGEFVESGRTVLLGVVPGAAPAARPSVEQVAAAAVSLTDRLGFPRAVLRERI 299 Query 301 GVSPACGLANATGQWARTAVGLARD 325 GV+PACGLA AT +WAR AV L + Sbjct 300 GVTPACGLATATPEWARRAVELTQK 324 >gi|2414535|emb|CAB16424.1| hypothetical protein MLCB637.09 [Mycobacterium leprae] Length=290 Score = 412 bits (1060), Expect = 3e-113, Method: Compositional matrix adjust. Identities = 228/290 (79%), Positives = 247/290 (86%), Gaps = 0/290 (0%) Query 48 MLGRAGGLLVDVAIDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRA 107 MLGRAG LL+DVAIDTVPRGYRIAARPGAVTRRA SLLDEDMDA E AWE AGLRG GR Sbjct 1 MLGRAGALLIDVAIDTVPRGYRIAARPGAVTRRAFSLLDEDMDAFEAAWEMAGLRGRGRV 60 Query 108 VKVQAPGPVTLVAGLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQF 167 VKVQAPGP+TL AGLELANGHRAITD AVRDLA SLAEGVAAHRAALARRLDT VVVQF Sbjct 61 VKVQAPGPITLAAGLELANGHRAITDSCAVRDLAESLAEGVAAHRAALARRLDTQVVVQF 120 Query 168 DEPSLPAALGGRLTGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQ 227 DE SLPAALGG LTGVTA SPVAPLDET+A L D+C+A V ADV LHSC+ +LPW+ LQ Sbjct 121 DEVSLPAALGGLLTGVTAFSPVAPLDETLAATLFDSCVATVGADVLLHSCAAELPWNFLQ 180 Query 228 RSRISAVSVDASTLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTD 287 RS I AVSVD + L+ DLD +AAFVESGRTVVLG+VP TAP+R PS+E+VAAA V VTD Sbjct 181 RSAIRAVSVDVNVLRTGDLDGIAAFVESGRTVVLGVVPATAPQRLPSVEQVAAAVVGVTD 240 Query 288 RLGVPRSALRDRLGVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 RLG RSALRDR+GVSPACGLA AT WA TA+ LAR AEAFA+DP+AI Sbjct 241 RLGFGRSALRDRIGVSPACGLAGATPHWACTAIELARKTAEAFAQDPDAI 290 >gi|169630433|ref|YP_001704082.1| putative methionine synthase, vitamin-B12 independent [Mycobacterium abscessus ATCC 19977] gi|169242400|emb|CAM63428.1| Putative methionine synthase, vitamin-B12 independent [Mycobacterium abscessus] Length=343 Score = 368 bits (944), Expect = 9e-100, Method: Compositional matrix adjust. Identities = 195/338 (58%), Positives = 241/338 (72%), Gaps = 3/338 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 VS++A TG+GSWPG AR+A ++VV EL L +L ELPARGVGAD++GRAG LLVD+A Sbjct 8 VSMWAKGTGLGSWPGQQARDATEIVVAELP--LPHLVELPARGVGADLIGRAGALLVDIA 65 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 ID P GYR ARPGAV RRA LDEDMDALEE WE G RG RAVKVQ PGPVTL A Sbjct 66 IDVSPTGYRTTARPGAVVRRARGFLDEDMDALEEEWERGGHRGSERAVKVQGPGPVTLAA 125 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 LEL NGHRAITDPGAVRD+AASLAEG+A HRA L+RRL PV+VQ DEPSLPAAL GRL Sbjct 126 ELELPNGHRAITDPGAVRDVAASLAEGLAQHRATLSRRLGVPVMVQIDEPSLPAALDGRL 185 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 +G + SPV P+D A ALLD C AV ++ +H C+ D PW+LL+ + I A+++D + Sbjct 186 SGTSMFSPVHPVDVPTATALLDQCAEAVGGELLVHCCASDPPWELLREANIRAIAIDVAH 245 Query 241 L-QAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDR 299 L A LD +A+ +++G+ VVLG++P AP S + +A A+ D+LG R+ LRDR Sbjct 246 LADAHALDGLASVLDTGKAVVLGVIPAQAPSTPISSDVLATRTAALADKLGFGRAMLRDR 305 Query 300 LGVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 +GVS CGLA QWAR A L R V++ DP+A+ Sbjct 306 VGVSAGCGLAGTDLQWARKATELTRKVSDLIDADPDAL 343 >gi|325675869|ref|ZP_08155553.1| vitamin-B12 independent methionine synthase [Rhodococcus equi ATCC 33707] gi|325553840|gb|EGD23518.1| vitamin-B12 independent methionine synthase [Rhodococcus equi ATCC 33707] Length=343 Score = 320 bits (819), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 179/325 (56%), Positives = 218/325 (68%), Gaps = 1/325 (0%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATG+GSWPGT R AA++VVGELA AL +L ELPARG+GADM+GRAG LL+D+ IDT Sbjct 11 ATGVGSWPGTDPRAAAEIVVGELA-ALPHLVELPARGIGADMIGRAGALLIDIPIDTSTT 69 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 GYR+A R GA TR A LL D+DALEEAWE AG RG + VKVQA GP+TL + LEL Sbjct 70 GYRLAQRVGAATRTARDLLARDLDALEEAWELAGRRGTDQPVKVQAVGPLTLASQLELHG 129 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTAL 186 GHR +TDPGA+RD+A SLAEGVA H A ARRL +PVVVQ DEP LPA L G L+GV+ L Sbjct 130 GHRVLTDPGALRDVAESLAEGVANHVADTARRLGSPVVVQLDEPGLPAVLAGSLSGVSIL 189 Query 187 SPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADL 246 L E A +L I +DA V +H C+ D+PW LL+RS + V D TL +DL Sbjct 190 QTPRALPEPEALHVLQQAIGRIDAPVLVHCCASDVPWGLLRRSGAAMVGFDVDTLGTSDL 249 Query 247 DAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPAC 306 D + ++ G + LGLVP PER P E+A A + DRLG PR L R+ V+PAC Sbjct 250 DGIGELLDGGVDLALGLVPTGEPERTPGWRELAEPATRLFDRLGFPRELLSSRVAVTPAC 309 Query 307 GLANATGQWARTAVGLARDVAEAFA 331 GLA A+ AR A+ A ++ AFA Sbjct 310 GLAGASLDRARAALRSANELTRAFA 334 >gi|312140512|ref|YP_004007848.1| methionine synthase [Rhodococcus equi 103S] gi|311889851|emb|CBH49168.1| putative secreted methionine synthase [Rhodococcus equi 103S] Length=343 Score = 317 bits (813), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 177/325 (55%), Positives = 217/325 (67%), Gaps = 1/325 (0%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATG+GSWPGT R +A++VVGELA AL +L ELPARG+GADM+GRAG LL+D+ IDT Sbjct 11 ATGVGSWPGTDPRASAEIVVGELA-ALPHLVELPARGIGADMIGRAGALLIDIPIDTSTT 69 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 GYR+A R GA TR A LL D+DALEEAWE AG RG + VKVQA GP+TL + LEL Sbjct 70 GYRLAQRVGAATRTARDLLARDLDALEEAWELAGRRGTDQPVKVQAVGPLTLASQLELHG 129 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTAL 186 GHR +TDPGA+RD+A SLAEGVA H A ARRL +PVVVQ DEP LPA L G L+GV+ L Sbjct 130 GHRVLTDPGALRDVAESLAEGVANHVADTARRLGSPVVVQLDEPGLPAVLAGSLSGVSIL 189 Query 187 SPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADL 246 L E A +L I +D V +H C+ D+PW LL+RS + V D TL +DL Sbjct 190 QTPRALPEPEALHVLQQAIGRIDGPVLVHCCASDVPWGLLRRSGAAMVGFDVDTLGTSDL 249 Query 247 DAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPAC 306 D + ++ G + LGLVP PER P E+A A + DRLG PR L R+ V+PAC Sbjct 250 DGIGELLDGGVDLALGLVPTGEPERTPGWRELAEPATRLFDRLGFPRELLSSRVAVTPAC 309 Query 307 GLANATGQWARTAVGLARDVAEAFA 331 GLA A+ AR A+ A ++ AFA Sbjct 310 GLAGASLDRARAALRSANELTRAFA 334 >gi|226305866|ref|YP_002765826.1| hypothetical protein RER_23790 [Rhodococcus erythropolis PR4] gi|226184983|dbj|BAH33087.1| conserved hypothetical protein [Rhodococcus erythropolis PR4] Length=340 Score = 305 bits (782), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 161/337 (48%), Positives = 219/337 (65%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 VS+ TGIGSWPGT ARE+A ++GEL G +L ELP+RG+GADM+GRAG +LVD+ Sbjct 5 VSIGGLVTGIGSWPGTDARESAATILGELGG-FPHLVELPSRGLGADMVGRAGAILVDIN 63 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 +D R YR+ R G V +RA L++D+DALEEAWE+A L G VK+QA GP+TL A Sbjct 64 LDASTRAYRVVPRRGNVAKRAEDFLNQDLDALEEAWESARLVGGDHVVKLQAAGPLTLGA 123 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 +E+ANG R + D GA+RD+A SL EG+A H A + RR VV+Q DEP + A L G L Sbjct 124 EIEVANGSRVLVDRGALRDIAESLGEGLARHAAEVTRRTGARVVIQLDEPQIAAVLAGSL 183 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 G T + V L E A A+LD+ I+ +HSC D+PWDLL+RS+ VS D S Sbjct 184 PGRTKMESVPALPEPEALAVLDSTISGCGLPTIVHSCGADMPWDLLRRSQAFGVSFDMSL 243 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 + + DLD + ++G+ + LGLVP T PE+ + +E A AV + DRLG R L++++ Sbjct 244 IGSRDLDGIGQLFDAGKELALGLVPSTPPEKPVTWKECAMPAVTLIDRLGFSRELLQNQV 303 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 V+P+CGLA A+ +W+R A+ L DV +A DP A Sbjct 304 AVTPSCGLAGASLEWSRAALRLCTDVGKALVDDPSAF 340 >gi|226365930|ref|YP_002783713.1| hypothetical protein ROP_65210 [Rhodococcus opacus B4] gi|226244420|dbj|BAH54768.1| hypothetical protein [Rhodococcus opacus B4] Length=340 Score = 304 bits (778), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 168/337 (50%), Positives = 225/337 (67%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +S+ TG+GSWPGT RE+A +V+GEL G L +L ELPARG+GADM+GRA LLVD+ Sbjct 5 ISLAGAVTGVGSWPGTDPRESATIVLGEL-GRLPHLVELPARGLGADMIGRASALLVDLQ 63 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 +D YR+ R G+V +RA LL++D+DALEEAWE+AGL G VKVQ+ GP+TL A Sbjct 64 LDVSTSAYRVVQRRGSVAKRATDLLNQDLDALEEAWESAGLVGADHVVKVQSVGPLTLAA 123 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 +EL G R +TDPGAVRD A SL EG+A H A + RRL V+VQFDEP LPA L G L Sbjct 124 EVELGTGRRVLTDPGAVRDFAESLGEGLARHAAEVTRRLGAQVLVQFDEPRLPAVLAGTL 183 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 +G + L V + E A A+L+ +A A +H CS DLP LL+RS AV +D + Sbjct 184 SGRSRLETVRAMPEPEALAVLEAALAGSGAVTMVHCCSGDLPTGLLRRSSARAVGLDVAQ 243 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L ++DLD + +++G+ + LGL+P TAP + ++A AV + DRLG PR+ LR ++ Sbjct 244 LASSDLDGIGELLDAGKELALGLIPATAPAVPATWRDLARPAVTLVDRLGFPRTTLRTQV 303 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 V+PACGLA A W+R A+ L DV+ AF DPE++ Sbjct 304 AVTPACGLAGADASWSRDALKLCADVSGAFTDDPESL 340 >gi|111023429|ref|YP_706401.1| hypothetical protein RHA1_ro06468 [Rhodococcus jostii RHA1] gi|110822959|gb|ABG98243.1| conserved hypothetical protein [Rhodococcus jostii RHA1] Length=340 Score = 304 bits (778), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 168/337 (50%), Positives = 223/337 (67%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 +S+ TG+GSWPGT REAA +V+GEL G L +L ELPARG+GADM+GRA LLVD+ Sbjct 5 ISLAGAVTGVGSWPGTDPREAATIVLGEL-GRLPHLVELPARGLGADMIGRASALLVDLQ 63 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 +D YR+ R G+V +RA LL++D+DALEEAW++AGL G VKVQ+ GP+TL A Sbjct 64 LDVSTTAYRVVQRRGSVAKRATDLLNQDLDALEEAWDSAGLVGADHVVKVQSVGPLTLAA 123 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 +EL G R +TDPGAVRD A SL EG+A H A + RRL V+VQFDEP LPA L G L Sbjct 124 EVELGTGRRVLTDPGAVRDFAESLGEGLARHAAEVTRRLGAQVLVQFDEPRLPAVLAGTL 183 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 +G + L V + E A A+L+ +A A +H CS DLP DLL+RS AV +D S Sbjct 184 SGRSRLETVRAMPEPEALAVLEAALAGCGAVTMVHCCSADLPTDLLRRSSARAVGLDVSQ 243 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 L + DLD + +++G+ + LGLVP T P + ++A AV + DRLG R+ LR ++ Sbjct 244 LASTDLDGIGELLDAGKELALGLVPTTVPAVPATWRDLARPAVTLIDRLGFARTTLRTQV 303 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 V+PACGLA A W+R A+ L +V+ AF DPE++ Sbjct 304 AVTPACGLAGADASWSREALKLCAEVSSAFTDDPESL 340 >gi|54026237|ref|YP_120479.1| hypothetical protein nfa42660 [Nocardia farcinica IFM 10152] gi|54017745|dbj|BAD59115.1| hypothetical protein [Nocardia farcinica IFM 10152] Length=337 Score = 303 bits (777), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 182/331 (55%), Positives = 222/331 (68%), Gaps = 1/331 (0%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATG+GSWPGT REAA V+GEL LA+L ELP RGVGADM+GR LLVD+ DT R Sbjct 6 ATGVGSWPGTDPREAAATVLGELPD-LAHLVELPERGVGADMIGRVSALLVDLRFDTSTR 64 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 GYR+ RPGAV+RRA LL D+DALEEAWET+G G GR +K+Q+ GP+TL A +EL N Sbjct 65 GYRLTPRPGAVSRRARDLLRADLDALEEAWETSGSAGTGRVLKLQSAGPLTLAAQVELPN 124 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTAL 186 GHRA+TDPGAVRDLA SLAEG+A H + RL VV+Q DEPSL A L G L GV+AL Sbjct 125 GHRALTDPGAVRDLADSLAEGLAGHAEEVRARLGAEVVLQLDEPSLGAVLAGTLRGVSAL 184 Query 187 SPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADL 246 V L E A+A+LD I A A V LHSC+ P LL+R+ +A++VD STL ADL Sbjct 185 DTVRALPEPEAQAVLDRVIDAQSAPVVLHSCADRPPLALLRRTAAAALAVDVSTLGTADL 244 Query 247 DAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPAC 306 D + ++SG +VLGLVP T P E A V + DRLG PR+ L + V+PAC Sbjct 245 DHLGEALDSGTRLVLGLVPTTEPAGEFGWREAAEPGVRLIDRLGFPRTLLATHILVAPAC 304 Query 307 GLANATGQWARTAVGLARDVAEAFARDPEAI 337 GLA A WAR A+ LA +V A+ PE++ Sbjct 305 GLAGAPLSWARRALTLAAEVTRAYTESPESL 335 >gi|333920879|ref|YP_004494460.1| hypothetical protein AS9A_3215 [Amycolicicoccus subflavus DQS3-9A1] gi|333483100|gb|AEF41660.1| hypothetical protein AS9A_3215 [Amycolicicoccus subflavus DQS3-9A1] Length=337 Score = 301 bits (771), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 173/337 (52%), Positives = 221/337 (66%), Gaps = 8/337 (2%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGA--LAYLTELPARGVGADMLGRAGGLLVD 58 ++VFATATG GSWPGT EAA+V++GEL+GA L YL ELPARGVGADM+GRA GLL+D Sbjct 1 MNVFATATGAGSWPGTEPHEAARVILGELSGAGSLPYLPELPARGVGADMIGRAAGLLID 60 Query 59 VAIDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTL 118 V +D P GYR++A+PGA+ RRA L D+DA EE WE AVK+Q GPVTL Sbjct 61 VPVDASPSGYRLSAKPGALWRRAREFLLRDVDAFEEQWERGAHGSDVGAVKIQVSGPVTL 120 Query 119 VAGLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGG 178 A LEL NGH A+ D GA RD+A SLAEGVA H A + RRL P+V Q DEP L AL G Sbjct 121 AANLELRNGHPALDDAGATRDIAESLAEGVAQHAADVGRRLGVPIVYQIDEPQLADALEG 180 Query 179 RLTGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISA----V 234 R+ GV+ L PV L + AEALL I +A + +H+CS +PW +L R +I+A V Sbjct 181 RIRGVSVLQPVRSLSSSEAEALLQKVIRVPEATM-VHTCSSSVPWGVLSRLKIAAAGLPV 239 Query 235 SVDASTLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRS 294 ++S L A++D+V AF++SGRT+V G+VP T A S EE+A +++ G + Sbjct 240 DAESSHLSGAEIDSVGAFLDSGRTLVFGVVP-TGSGAARSAEELAQRVMSLGSAAGFAQK 298 Query 295 ALRDRLGVSPACGLANATGQWARTAVGLARDVAEAFA 331 L + GVSP CGLA + A+ A GLARDV + A Sbjct 299 VLVRQAGVSPQCGLAGVSAAAAKRATGLARDVMKQLA 335 >gi|229493393|ref|ZP_04387182.1| methionine synthase, vitamin-B12 independent [Rhodococcus erythropolis SK121] gi|229319709|gb|EEN85541.1| methionine synthase, vitamin-B12 independent [Rhodococcus erythropolis SK121] Length=340 Score = 299 bits (766), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 160/337 (48%), Positives = 213/337 (64%), Gaps = 1/337 (0%) Query 1 VSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA 60 VS+ TGIGSWPGT ARE+A ++GEL G +L ELP+RG+GADM+GRAG +LVD+ Sbjct 5 VSIGGLVTGIGSWPGTDARESAATILGELGG-FPHLVELPSRGLGADMVGRAGAILVDIN 63 Query 61 IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA 120 +D R YR+ R G V +RA L++D+DALEEAWE+A L G VK+Q GP+TL A Sbjct 64 LDASTRAYRVVPRRGNVAKRAEDFLNQDLDALEEAWESARLVGEDHVVKLQVAGPLTLGA 123 Query 121 GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL 180 +E+ANG R + D GA+RD+A SL EG+A H A + RR VV+Q DEP + A L G L Sbjct 124 EIEVANGSRVLVDRGALRDVAESLGEGLARHAAEVTRRTGAAVVIQLDEPQIAAVLAGSL 183 Query 181 TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 G T + V L E A A+LD+ I+ +HSC D+PWDLL+RS+ VS D S Sbjct 184 PGRTKMESVPALPEPEALAVLDSTISGCGLPTIVHSCGTDMPWDLLRRSQAFGVSFDMSL 243 Query 241 LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 + + DLD + ++G+ + LGLVP PE+ + +E A AV + DRLG R L+ ++ Sbjct 244 IGSRDLDGIGQLFDAGKELALGLVPSVEPEKPVTWKECAMPAVTLVDRLGFSRELLQTQV 303 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 V+P CGLA A WAR A+ L DV +A DP A Sbjct 304 AVTPRCGLAGANLDWARAALRLCTDVGKALVDDPSAF 340 >gi|326381519|ref|ZP_08203213.1| methionine synthase vitamin-B12 independent [Gordonia neofelifaecis NRRL B-59395] gi|326199766|gb|EGD56946.1| methionine synthase vitamin-B12 independent [Gordonia neofelifaecis NRRL B-59395] Length=349 Score = 264 bits (675), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 161/329 (49%), Positives = 200/329 (61%), Gaps = 5/329 (1%) Query 8 TGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRG 67 TGIGS PGT REA +V GEL L +L ELPARGVGADM+GR G LLV++ +D V R Sbjct 22 TGIGSMPGTQPREAIRVAAGELD--LPFLPELPARGVGADMIGRTGALLVELPVDMVHRA 79 Query 68 YRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANG 127 YR+A P TRRAA L D+DALEE WET GL G G VKVQA GP+T A +EL G Sbjct 80 YRLADHPNTTTRRAADWLRWDLDALEEHWETTGLTGTG-VVKVQACGPLTFAANVELRGG 138 Query 128 HRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALS 187 H+ + D GAVRD+AASL EG+ H A + RRL VVVQ DEP + + G +T +T L Sbjct 139 HKIVKDRGAVRDVAASLTEGLRNHIAEVRRRLGARVVVQLDEPDVGRVIDGTVTPLTRLD 198 Query 188 PVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA-ADL 246 P+ P+ A LL I A+ V LHSC WDL R A+S+D + L+ D Sbjct 199 PIRPVAAPDAAELLQQMIDALGVPVLLHSCGRPR-WDLTGRLERVALSLDVTGLRPDRDY 257 Query 247 DAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPAC 306 DA+ AF++SG + GL+P P E +A DR+G+PR LRD L V+P C Sbjct 258 DALGAFIDSGGVLAAGLIPTAEPPGPVDAESLAGRLTETVDRIGLPRRILRDNLLVTPTC 317 Query 307 GLANATGQWARTAVGLARDVAEAFARDPE 335 GLA+AT WA A+ LA +VA A DP+ Sbjct 318 GLASATPAWAARALTLASEVASGLAADPD 346 >gi|343926873|ref|ZP_08766366.1| hypothetical protein GOALK_072_00950 [Gordonia alkanivorans NBRC 16433] gi|343763233|dbj|GAA13292.1| hypothetical protein GOALK_072_00950 [Gordonia alkanivorans NBRC 16433] Length=355 Score = 261 bits (666), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 146/330 (45%), Positives = 194/330 (59%), Gaps = 3/330 (0%) Query 8 TGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRG 67 TG+GS PGT R AA VV GEL LA+L ELP RG G+D++GR +LVD+ +DT G Sbjct 29 TGVGSMPGTDPRAAAAVVNGELD--LAHLVELPGRGAGSDLIGRMAAILVDLPMDTATWG 86 Query 68 YRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANG 127 YR+A R +TRRA L ED+D +EE WETAG G GR KVQ GP T A +EL NG Sbjct 87 YRLAQRESQLTRRARDFLKEDLDVVEELWETAGFVGTGRPFKVQVAGPFTTSASVELPNG 146 Query 128 HRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALS 187 HR + DPGAVRD+ AS AEG+ H + RRL VVVQ DEP + + G + +T Sbjct 147 HRVLKDPGAVRDIVASTAEGLREHVGEIKRRLGAQVVVQIDEPMIGRVIDGTVKPLTRFD 206 Query 188 PVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADLD 247 P+ + A L I VDA V LH C+ WDLL+ R A S+D + ADLD Sbjct 207 PIRAVPAVEAARALTELIEHVDAPVVLHDCNRPR-WDLLEHLRGVAYSIDVTAPTDADLD 265 Query 248 AVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPACG 307 + ++ G +V G +P TAP+R + + VA A+TDR+G+ R L + + V+P CG Sbjct 266 GIGMLIDRGDILVAGRIPSTAPKRPVNADTVATDLAAITDRIGLSRKVLSENVIVTPTCG 325 Query 308 LANATGQWARTAVGLARDVAEAFARDPEAI 337 LA A+ WA+ A+ + + + DP A+ Sbjct 326 LAGASESWAKKALAVTAEAGQLLGTDPTAL 355 >gi|302524938|ref|ZP_07277280.1| methionine synthase [Streptomyces sp. AA4] gi|302433833|gb|EFL05649.1| methionine synthase [Streptomyces sp. AA4] Length=344 Score = 258 bits (658), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 158/336 (48%), Positives = 200/336 (60%), Gaps = 11/336 (3%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATGIGS PGT EAA VV GEL G Y+ ELPARGVGAD++GR LLVD+AI+ VP Sbjct 11 ATGIGSMPGTDPVEAAAVVFGELPG-FPYVPELPARGVGADLVGRTAALLVDLAIEVVPS 69 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 GYR+A RPG RR LL D+DA++ A E G +K Q GP TL AG+ELA Sbjct 70 GYRVAGRPGHDHRRGRDLLQWDLDAVQAARENTGAPAV---LKTQIAGPWTLGAGVELAR 126 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTAL 186 GHR +TD GA+RD +SL +G++ H A L R D PVVVQ DEPSLPA L G+L + Sbjct 127 GHRVLTDRGALRDFTSSLLDGLSQHVAELTARTDAPVVVQLDEPSLPAVLAGKLPTPSGY 186 Query 187 SPVAPLDETVAEALLDTCIAAVDA----DVALHSCSPDLPWDLLQRSRISAVSVDASTLQ 242 V + E LL T I + V +H C+P P L + + A++ D S L Sbjct 187 GNVPAVPEPEVRELLATTIERIGTMTGQPVIVHCCAPRPPIALFRAAGAGAIAFDISMLA 246 Query 243 AAD---LDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDR 299 A LD + +SG + LGLVP T P AP ++++AA A+ + DRLG RS L +R Sbjct 247 GASAELLDEIGEAWDSGISFFLGLVPATDPVTAPGLKDLAAPALKLVDRLGFNRSILAER 306 Query 300 LGVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 +PACGLA AT QW R A+ L+RD+ + F PE Sbjct 307 AVPTPACGLAGATNQWMRRALALSRDLGKGFVEPPE 342 >gi|257054922|ref|YP_003132754.1| cobalamin-independent methionine synthase [Saccharomonospora viridis DSM 43017] gi|256584794|gb|ACU95927.1| cobalamin-independent methionine synthase [Saccharomonospora viridis DSM 43017] Length=362 Score = 248 bits (632), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 157/336 (47%), Positives = 200/336 (60%), Gaps = 12/336 (3%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATG+GS PGT EAA +V GEL +L ELPARG GAD++GR LLVD+A++ VP Sbjct 30 ATGVGSMPGTDPGEAAAIVFGELP-EFPHLFELPARGAGADVIGRTAALLVDLAVEIVPS 88 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 GYR+ A+PG RRA LL D+DA EA + G VK Q GP TL AG+ELA Sbjct 89 GYRVTAKPGRDHRRAVDLLRWDVDAFSEAAD----EGSPSVVKTQLAGPWTLAAGVELAR 144 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTAL 186 GHR +TD GA+RD SL EGVAAH + LA R VVVQ DEP+LP L G L + Sbjct 145 GHRVLTDHGALRDFTESLIEGVAAHVSELAERTGARVVVQLDEPTLPDVLAGSLPTPSGY 204 Query 187 SPVAPLDETVAEALLDTCI----AAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQ 242 VA + E A LL T + AA V +H C+ P LL+ + AVS+DA+ L Sbjct 205 GTVAAVPEPQARELLGTVVDAARAATGCPVVVHCCARRPPVGLLRAAGADAVSLDATLLD 264 Query 243 AAD---LDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDR 299 A LD + ++ +LGLVP AP+R P ++++A A + DRLG RS L +R Sbjct 265 DAPGELLDEIGEAYDAEVMFLLGLVPGRAPDRRPELKQLARPAFDLVDRLGFARSTLAER 324 Query 300 LGVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 + +P CGLA ATG+W RTA+ L RD+ +AF PE Sbjct 325 VLPTPTCGLAGATGEWLRTALSLTRDLGKAFIDPPE 360 >gi|331695632|ref|YP_004331871.1| methionine synthase vitamin-B12 independent [Pseudonocardia dioxanivorans CB1190] gi|326950321|gb|AEA24018.1| Methionine synthase vitamin-B12 independent [Pseudonocardia dioxanivorans CB1190] Length=421 Score = 238 bits (606), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 157/334 (48%), Positives = 198/334 (60%), Gaps = 15/334 (4%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATG+GS PGT REAA +V GE+ GA+ ++ ELP RGVGAD+ GR GLLVD+A++ VP Sbjct 81 ATGVGSMPGTDVREAAAIVAGEV-GAMPFVPELPGRGVGADLTGRTAGLLVDIAVEVVPT 139 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 GYR+ RPG RRA L+ D+DA +EA + +R VKVQA GP TL A +E Sbjct 140 GYRVTQRPGRDHRRAVDLMRGDLDAFDEACDA--IRPG--WVKVQAAGPWTLAATVETHA 195 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTAL 186 GHR +TD GAVRD AASL EG+ H A +A R VVVQ DEP+LPA L G L + Sbjct 196 GHRVLTDRGAVRDFAASLQEGLRGHVAEVAARTGARVVVQLDEPALPAVLRGSLPTASGY 255 Query 187 SPVAPLDETVAEALLDTCI---AAVDADVALHSCSPDLPWDLLQRSRISAVSVDAS---- 239 V ++E A LL + AAV + V LH C+ D P LL +AV +D + Sbjct 256 GTVRAIEENDAADLLRDAVDAFAAVGSPVVLHCCADDPPMKLLAGVGAAAVGIDGTRRAI 315 Query 240 ---TLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSAL 296 T A LDAV ++G ++LGLV TAP R P + +A A + DRLG R L Sbjct 316 SGDTALPAALDAVGEVWDAGTPIMLGLVRTTAPARTPEVAVLAQRAFDLADRLGFARHRL 375 Query 297 RDRLGVSPACGLANATGQWARTAVGLARDVAEAF 330 + +P CGLA AT WARTA+GL R + EAF Sbjct 376 AELAVPTPTCGLAGATPDWARTALGLCRQLGEAF 409 >gi|262203143|ref|YP_003274351.1| methionine synthase vitamin-B12 independent [Gordonia bronchialis DSM 43247] gi|262086490|gb|ACY22458.1| Methionine synthase vitamin-B12 independent [Gordonia bronchialis DSM 43247] Length=336 Score = 236 bits (601), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 142/330 (44%), Positives = 192/330 (59%), Gaps = 15/330 (4%) Query 14 PGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRGYRIAAR 73 PGT AR+AA +V GEL A+L ELPARG+GADM+GR +LVD+ +DT +GYR++AR Sbjct 16 PGTDARDAAAIVHGELD--FAHLVELPARGLGADMIGRMAAVLVDLPMDTATQGYRLSAR 73 Query 74 PGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANGHRAITD 133 P +TRRAA LL ED+D EE WETAG G G+ KV GP TL A +EL GH+ + D Sbjct 74 PSRLTRRAADLLHEDLDMAEEIWETAGFVGSGKPFKVAVAGPFTLAASVELRTGHKVLRD 133 Query 134 PGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALS-----P 188 GAVRDL AS AEGV A + RRL V+VQ DEP + + + G + +T P Sbjct 134 RGAVRDLIASCAEGVRELAAEVTRRLGAQVIVQLDEPMIGSVIDGTVRPLTRFDVLDAIP 193 Query 189 VAPLDETVAEALLDTCIAAVDADVALHSC-SPDLPWDLLQRSRISAVSVDASTLQAADLD 247 V + E +A+ I + LH C +P WDLL R A+S D + AADLD Sbjct 194 VVEVAEALAQ-----LIDVIGRRAVLHDCGTP--RWDLLSRLPGVALSADVTAPSAADLD 246 Query 248 AVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPACG 307 + ++ G T++ G+VP +R + VAAA +TDR+G+ R L + V+P CG Sbjct 247 GIGELIDRGDTLLAGIVPAVGEDRHAHADTVAAALATLTDRIGLDRKVLAQNVIVTPTCG 306 Query 308 LANATGQWARTAVGLARDVAEAFARDPEAI 337 LA A+ WA+ A+ + DP+A+ Sbjct 307 LAGASETWAKRALAICAQAGHLLGSDPDAL 336 >gi|296140602|ref|YP_003647845.1| methionine synthase vitamin-B12 independent [Tsukamurella paurometabola DSM 20162] gi|296028736|gb|ADG79506.1| Methionine synthase vitamin-B12 independent [Tsukamurella paurometabola DSM 20162] Length=335 Score = 233 bits (593), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 145/325 (45%), Positives = 186/325 (58%), Gaps = 6/325 (1%) Query 6 TATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVP 65 T TGIGS PGT REAA VVGELA + YL ELP RG+GADM+GR+ G L + +D Sbjct 11 TTTGIGSHPGTDPREAAATVVGELA--VPYLPELPNRGLGADMIGRSAGFLTGIGVDIST 68 Query 66 RGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELA 125 GYRI G V R L D+D+ EEA+E AG RG G VKVQA GP+TL AGLEL Sbjct 69 TGYRIGVPDGHVARLIGDHLQRDLDSFEEAYEVAGRRGGG-LVKVQAAGPLTLAAGLELP 127 Query 126 NGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTA 185 NGHR D GA+RD+A SLAEG+ H + + RRL VVVQ DEPS+ + + G + +T Sbjct 128 NGHRVPRDRGALRDIAESLAEGLRQHVSDVRRRLGAEVVVQLDEPSMASVVRGTVPALTR 187 Query 186 LSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAAD 245 L P+ + A LL AVD V LH C P + WD+++R I DA+ L AD Sbjct 188 LDPIRGVPAPEAAELLSRVCEAVDVPVLLHLCGP-IEWDVVRRVPIDGALFDATRLAVAD 246 Query 246 LDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPA 305 + E+ V LGLVP T +R E +A A+ + D +G+PR L D V+P Sbjct 247 YEGFGMLAEASAVVGLGLVPATGTQRL-DPESLARTAIRLYDEIGLPRRTLADAT-VTPV 304 Query 306 CGLANATGQWARTAVGLARDVAEAF 330 CGL+ + R +G + +A Sbjct 305 CGLSGSPDDRIRPILGACKTIASVL 329 >gi|300783589|ref|YP_003763880.1| vitamin-B12 independent methionine synthase [Amycolatopsis mediterranei U32] gi|299793103|gb|ADJ43478.1| vitamin-B12 independent methionine synthase [Amycolatopsis mediterranei U32] gi|340524979|gb|AEK40184.1| vitamin-B12 independent methionine synthase [Amycolatopsis mediterranei S699] Length=329 Score = 229 bits (585), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 150/329 (46%), Positives = 194/329 (59%), Gaps = 10/329 (3%) Query 14 PGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRGYRIAAR 73 PG EAA VV GEL +L ELPARGVGAD+LGR+ LLVD+A++ VP GYR+A+R Sbjct 2 PGDDPAEAAAVVFGELPD-FPHLPELPARGVGADVLGRSAALLVDLAVEVVPSGYRVASR 60 Query 74 PGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANGHRAITD 133 PG RRA LL D+DA++EA E +G+ KVQ GP TL AG+EL GHR +TD Sbjct 61 PGHEHRRALDLLRWDLDAVQEAREKSGV--TPPLFKVQLAGPWTLGAGIELPRGHRVLTD 118 Query 134 PGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALSPVAPLD 193 GA+RD +SL +G+A H A + R+ PVVVQFDEPSLPA L G L+ + V + Sbjct 119 RGALRDFTSSLLDGLAEHVAEVRARIGAPVVVQFDEPSLPAVLAGDLSTPSGYGNVPAVP 178 Query 194 ETVAEALLDTCIAA----VDADVALHSCSPDLPWDLLQRSRISAVSVDASTL---QAADL 246 A LL T I D V LH C+ P LL+ + A++ D + L AA L Sbjct 179 APEARQLLTTVIEGARRITDRPVILHCCAAKPPLRLLREAGADALAFDLAALDGASAAFL 238 Query 247 DAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPAC 306 D + + G T+ +G VP T+P S+++V A + DRLG RS L +R +PAC Sbjct 239 DEIGEVWDGGATLFMGAVPTTSPSSPLSLKDVGEPAFRLADRLGFNRSVLAERAVPTPAC 298 Query 307 GLANATGQWARTAVGLARDVAEAFARDPE 335 GLA AT W R A+ L RD+ +AF PE Sbjct 299 GLAGATPDWMRRALALTRDLGKAFVEPPE 327 >gi|337768307|emb|CCB77020.1| conserved protein of unknown function [Streptomyces cattleya NRRL 8057] Length=351 Score = 229 bits (583), Expect = 6e-58, Method: Compositional matrix adjust. Identities = 155/337 (46%), Positives = 198/337 (59%), Gaps = 13/337 (3%) Query 6 TATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVP 65 TATG+GS PG AREAA+V VGE+ AL +L ELPARG GADM+GR G+LV++ P Sbjct 21 TATGVGSLPGEDAREAARVAVGEVP-ALPFLPELPARGPGADMIGRTLGMLVELYARVEP 79 Query 66 RGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELA 125 G+R RPG TRRA S L ED+DALEE T G G +K+QA GP TL AG+EL Sbjct 80 SGWRFGDRPGRDTRRARSYLGEDLDALEEF--TQGYAG---PLKIQAVGPWTLAAGVELR 134 Query 126 NGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGVT 184 G A+ DPGA RDL ASLAEG+ AH A + RR+ V++Q DEPSL A L G + + Sbjct 135 GGEAALGDPGACRDLTASLAEGLRAHVAEVRRRVPGAEVLLQLDEPSLTAVLRGNVRTAS 194 Query 185 ALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAA 244 +D VAE L I AV V +HSC+PD+P+ L+R+ + +S D S L Sbjct 195 GYRTHRAVDRQVAEGALRQVIEAVGVPVTVHSCAPDVPFAFLRRAGATGISFDFSLLTER 254 Query 245 DLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTD------RLGVPRSALRD 298 D DAV VE+G + G+VP TAP+ A ++ A +V+ LG+ AL Sbjct 255 DWDAVGESVEAGTVLFAGVVPGTAPDAAGGTAALSDPAGSVSGVRSLWRGLGLSPGALSQ 314 Query 299 RLGVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 + V+PACGLA AT +AR A+ A DPE Sbjct 315 SVVVAPACGLAGATPGYARAALAHCVKAARTLVDDPE 351 >gi|134102619|ref|YP_001108280.1| methionine synthase, vitamin-B12 independent [Saccharopolyspora erythraea NRRL 2338] gi|291004696|ref|ZP_06562669.1| methionine synthase, vitamin-B12 independent [Saccharopolyspora erythraea NRRL 2338] gi|133915242|emb|CAM05355.1| methionine synthase, vitamin-B12 independent [Saccharopolyspora erythraea NRRL 2338] Length=342 Score = 228 bits (580), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 152/338 (45%), Positives = 198/338 (59%), Gaps = 14/338 (4%) Query 6 TATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLV-DVAIDTV 64 TAT IGS PGT EAA+ VVGEL + + ELPARGVGAD++GR G+LV D+A++ V Sbjct 10 TATAIGSMPGTDPVEAARTVVGELPELMPF-PELPARGVGADLIGRTAGMLVGDLAVEVV 68 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 P GYR+A RPG +RA LL D+DA+E+A A G R VKVQA GP TL AG+EL Sbjct 69 PSGYRVAGRPGHDQQRAVDLLRWDLDAVEQA---AAEAGAPRVVKVQAAGPWTLAAGIEL 125 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVT 184 GHR +TD GA+RD SL EG+ H +A R VVVQ DEPSLPA L GRL + Sbjct 126 MRGHRVLTDHGALRDFTESLTEGLTEHAGQVAARTGARVVVQLDEPSLPAVLNGRLPTPS 185 Query 185 ALSPV----APLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST 240 V AP + +++T AA + V +H C+ P LL+R+ A+++DA+ Sbjct 186 GYGTVPAVPAPDAQRRLAEVIETLAAATGSPVVVHCCARRPPVALLRRAGAGAIALDATG 245 Query 241 L---QAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALR 297 L D + E G T+ LGLVP + E ++ +VA A + RLG R L Sbjct 246 LGDVTGEFADELGETWEEGTTLFLGLVP--SRETETTLRQVAQPAFDLATRLGFSRRTLA 303 Query 298 DRLGVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 +R +P CG A A+ WAR A+GL RD+A FA + E Sbjct 304 ERGVPTPTCGFAGASPAWARRAIGLTRDLARMFADEAE 341 >gi|269127768|ref|YP_003301138.1| methionine synthase vitamin-B12 independent [Thermomonospora curvata DSM 43183] gi|268312726|gb|ACY99100.1| Methionine synthase vitamin-B12 independent [Thermomonospora curvata DSM 43183] Length=337 Score = 222 bits (565), Expect = 8e-56, Method: Compositional matrix adjust. Identities = 139/331 (42%), Positives = 202/331 (62%), Gaps = 8/331 (2%) Query 6 TATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVP 65 +ATG+GS+PG EA +VV+GEL G L +L ELP RG GAD++GRA GLLV++ ++ P Sbjct 13 SATGVGSYPGDDPAEALRVVLGELPG-LPHLPELPGRGPGADLIGRAAGLLVELPVELQP 71 Query 66 RGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELA 125 G+R+A RPG RRA L D+DALEE G G +K+Q GP TL AG+EL Sbjct 72 SGWRLAGRPGRDLRRAHDHLARDLDALEEV--AGGYEG---PLKIQVCGPWTLAAGVELP 126 Query 126 NGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGVT 184 +GHR + D GAVRDL ASLAEGVA H A + RR+ V++Q DEP LPA L G + + Sbjct 127 SGHRTLKDAGAVRDLIASLAEGVAGHVAEIRRRVPGARVLLQLDEPGLPAVLAGTVPTAS 186 Query 185 ALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAA 244 + + ++E VA L I A DA +H C+ +P+ LL+++ +S+D S + Sbjct 187 GFARLPAVEEAVAVDGLRRVIEAADAWPLVHCCARRVPYGLLRKAGAKGISIDLSLVPDR 246 Query 245 DLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSP 304 D D + +++G + LG++P T + PS+++ AA A + RLG P + L ++ ++P Sbjct 247 DDDPIGETIDAGVALFLGVLPGTD-TQLPSLQDTAAPARELWRRLGFPAATLGEQTVITP 305 Query 305 ACGLANATGQWARTAVGLARDVAEAFARDPE 335 ACGLA A+ ++ R A+ R+VA P+ Sbjct 306 ACGLAGASPRYVRAALKRCREVARTLHEAPQ 336 >gi|345002207|ref|YP_004805061.1| methionine synthase vitamin-B12 independent [Streptomyces sp. SirexAA-E] gi|344317833|gb|AEN12521.1| Methionine synthase vitamin-B12 independent [Streptomyces sp. SirexAA-E] Length=341 Score = 221 bits (562), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 148/336 (45%), Positives = 196/336 (59%), Gaps = 13/336 (3%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGA--LAYLTELPARGVGADMLGRAGGLLVDVAIDTV 64 ATGIGS PG AREAA+ VVG A L YL ELPARG GADM+GR GLL ++ Sbjct 12 ATGIGSMPGGDAREAAKTVVGSFADGQGLPYLPELPARGPGADMIGRTVGLLEEMYGHVE 71 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 P G+RI+ RPG TRRA S L ED+DALEE T G G +KVQA GP TL AGLEL Sbjct 72 PSGWRISDRPGRDTRRARSWLGEDLDALEEF--TQGYEGL---LKVQAVGPWTLAAGLEL 126 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGV 183 G + DPGA RDLA SLAEG+ H A + RR+ +V+Q DEPSL A L GR+ Sbjct 127 RGGEAMVADPGACRDLAGSLAEGLRGHLAEVRRRIPGAEIVLQLDEPSLTAVLRGRVRSA 186 Query 184 TALSPVAPLDETVAEALLDTCIAAVDAD-VALHSCSPDLPWDLLQRSRISAVSVDASTLQ 242 + +D V E L +A D +HSC+PD+P+ LL+R+ +VS D S L Sbjct 187 SGYRTYRAVDRQVVEGALRDLLAVNDGGPTTVHSCAPDVPFALLRRAGAGSVSFDFSLLT 246 Query 243 AADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVT---DRLGVPRSALRDR 299 + +A+ VE G ++LG+VP A ++ + + + V +RLG+ L + Sbjct 247 EREEEAIGEAVEDGTQLLLGVVPSLDAASA-ALSDPGGSVMGVRTLWNRLGLNPGTLAES 305 Query 300 LGVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 + ++P+CGLA A+ +ARTA+ A + A +PE Sbjct 306 VVITPSCGLAGASPAYARTALAHCVRAARSLANNPE 341 >gi|302537076|ref|ZP_07289418.1| methionine synthase vitamin-B12 independent [Streptomyces sp. C] gi|302445971|gb|EFL17787.1| methionine synthase vitamin-B12 independent [Streptomyces sp. C] Length=327 Score = 218 bits (556), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 145/333 (44%), Positives = 191/333 (58%), Gaps = 10/333 (3%) Query 5 ATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTV 64 A+ATG+GS PG AREAA+ G YL ELPARG GADM+GR+ GLLVD+ Sbjct 3 ASATGVGSLPGGDAREAAKTATGSFE-EFPYLPELPARGPGADMIGRSLGLLVDMYAHVE 61 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 P G+R++ RPG TRRA S L ED+DALEE T G G +KVQA GP TL LEL Sbjct 62 PSGWRVSDRPGRDTRRARSWLGEDLDALEEF--TQGHTG---KLKVQAVGPWTLATALEL 116 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGV 183 G + DPGA RDLAASLAEG+ H A + +R+ +V+Q+DEPSL A L GR+ Sbjct 117 HGGEAVLQDPGACRDLAASLAEGLRDHLADVRKRIPGAEIVLQYDEPSLTAVLRGRVRSA 176 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 + +D V E+ L A D +V +HSC+P++P+ LL R+ + VS D S L Sbjct 177 SGYRTYRAVDRQVVESTLRDLFAVHDGEVVVHSCAPEVPFALLHRAGATGVSFDFSLLTE 236 Query 244 ADLDAVAAFVESGRTVVLGLVPVT-APERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGV 302 + DA+ VE G + G+VP T AP P + + RLG+ L + + V Sbjct 237 REDDAIGEAVEGGLKLFTGVVPGTDAPLSDPGGSVMGVR--KLWRRLGLAPGTLAESVVV 294 Query 303 SPACGLANATGQWARTAVGLARDVAEAFARDPE 335 +P+CGLA A+ +AR A A + A +PE Sbjct 295 TPSCGLAGASPAYARAAQAHCVRAARSLADNPE 327 >gi|302542308|ref|ZP_07294650.1| methionine synthase, vitamin-B12 independent [Streptomyces hygroscopicus ATCC 53653] gi|302459926|gb|EFL23019.1| methionine synthase, vitamin-B12 independent [Streptomyces himastatinicus ATCC 53653] Length=337 Score = 217 bits (553), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 153/335 (46%), Positives = 198/335 (60%), Gaps = 14/335 (4%) Query 5 ATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTV 64 A ATG+GS PG AREAA+ V G L AL YL ELP RG GADM+GR G+LV+V Sbjct 13 AAATGVGSMPGDDAREAAKTVTGSLE-ALPYLPELPVRGPGADMIGRTAGMLVEVYAHVE 71 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 P G+RI+ RPG TRRA S L ED+DALEE T G RG A+KV A GP TL LEL Sbjct 72 PSGWRISDRPGRDTRRARSWLGEDLDALEEF--TQGHRG---ALKVSAVGPWTLAGSLEL 126 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGV 183 NG A++DPGA RDL ASLAEG+ AH A + RR+ VV+Q DEPSL A L G + Sbjct 127 RNGEVALSDPGACRDLTASLAEGLRAHLAEVRRRVPGAEVVLQLDEPSLTAVLTGTVRTA 186 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 + A +D V E L +AA A V +HSC+P++P+ LL+RS S VS D S L Sbjct 187 SGYRTHAAVDRGVVEGALRDLVAAAQAPVVVHSCAPNVPFGLLRRSGASGVSFDFSLLTE 246 Query 244 ADLDAVAAFVESGRTVVLGLVP---VTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 + +A+ VE G ++ +G VP + A S+ V + RLG+ L + + Sbjct 247 REEEAIGEAVEGGTSLFIGAVPGIDTALSDPAGSVRGVR----TLWRRLGLSPGTLAESV 302 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 ++P+CGLA A+ +AR A+ A + A +PE Sbjct 303 VITPSCGLAGASPAYARAALAHCVRAARSLADNPE 337 >gi|297191910|ref|ZP_06909308.1| methionine synthase [Streptomyces pristinaespiralis ATCC 25486] gi|197721111|gb|EDY65019.1| methionine synthase [Streptomyces pristinaespiralis ATCC 25486] Length=337 Score = 217 bits (552), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 142/335 (43%), Positives = 193/335 (58%), Gaps = 9/335 (2%) Query 4 FATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDT 63 + ATG+GS PG AREAA+ V G A+L ELPARG GADM+GR GLLV++ Sbjct 9 WGPATGVGSLPGGDAREAARTVTGSFE-EFAHLAELPARGPGADMIGRTVGLLVEMYAHV 67 Query 64 VPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLE 123 P G+RI+ RPG TRRA S + ED+DALEE T G G +KVQA GP TL A LE Sbjct 68 EPSGWRISDRPGRDTRRARSWMGEDLDALEEF--TQGYEG---PLKVQAVGPWTLAAALE 122 Query 124 LANGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTG 182 G A+ DPGA RDLAASLAEG+ H A + RR+ VV+Q DEPSL A L G++ Sbjct 123 RRGGEAALGDPGACRDLAASLAEGLRDHLAEVRRRVPGARVVLQLDEPSLTAVLRGQVRT 182 Query 183 VTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQ 242 + +D V E+ L +AA D V +HSC+PD+P+ LL+R+ + +S D L Sbjct 183 ASGYRTYRAVDRQVVESTLRDVMAATDGPVVVHSCAPDVPFALLRRAGVQGISFDFGLLT 242 Query 243 AADLDAVAAFVESGRTVVLGLVPVT--APERAPSMEEVAAAAVAVTDRLGVPRSALRDRL 300 D +++ VE+G + G+VP T A + ++ + RLG+ L + + Sbjct 243 ERDEESIGEAVEAGTKLFAGVVPSTDAASDGLSVGADIVKGVRTLWRRLGLNPGTLAESI 302 Query 301 GVSPACGLANATGQWARTAVGLARDVAEAFARDPE 335 ++P CGLA A+ +AR A+ A + A +PE Sbjct 303 VITPTCGLAGASPAYARAALAHCVRAARSLADNPE 337 >gi|271969280|ref|YP_003343476.1| hypothetical protein Sros_8078 [Streptosporangium roseum DSM 43021] gi|270512455|gb|ACZ90733.1| hypothetical protein Sros_8078 [Streptosporangium roseum DSM 43021] Length=334 Score = 216 bits (551), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 140/332 (43%), Positives = 195/332 (59%), Gaps = 10/332 (3%) Query 5 ATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTV 64 ATATG+GS PG EA +VV GEL AL YL ELPARGVGAD++GR LLVD+A++ Sbjct 9 ATATGVGSHPGADHAEAIRVVFGELP-ALPYLPELPARGVGADLIGRTASLLVDLAVEVQ 67 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 P G+R A RPG +RA L D+DALEE+ + G G K+Q GP TL +EL Sbjct 68 PSGWRFADRPGRDFKRARDHLVRDLDALEESAQ--GYEG---PFKIQVCGPWTLAGAVEL 122 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLD--TPVVVQFDEPSLPAALGGRLTG 182 +G + + DPGAVRDL S AEG+AAH A + RR+ + +VVQ DEP LP L G + Sbjct 123 RHGDKTLADPGAVRDLVGSFAEGLAAHVADVRRRVPGASQIVVQLDEPGLPGVLAGTVPT 182 Query 183 VTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQ 242 + +A ++ +A L + A +H C+P +P+ +L+ + +S+DAS L+ Sbjct 183 ASGFGRLAAVEAPIAAERLGEVLPE-GAFTVVHCCAPGVPFGVLRAAGAGGISLDASLLR 241 Query 243 AADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGV 302 D DA+ +E+G LG+VP R P ++ VA AV + RLG P + L ++ + Sbjct 242 RRDEDAIGEAIEAGTAFFLGVVP-GVDSRLPDVDVVAKPAVKLWRRLGFPVATLASQVVL 300 Query 303 SPACGLANATGQWARTAVGLARDVAEAFARDP 334 +PACGLA A+ +AR A+ R+ A DP Sbjct 301 TPACGLAGASPGYARAALAKVREAARVLRDDP 332 >gi|325003019|ref|ZP_08124131.1| cobalamin-independent methionine synthase [Pseudonocardia sp. P1] Length=393 Score = 216 bits (550), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 157/342 (46%), Positives = 205/342 (60%), Gaps = 23/342 (6%) Query 8 TGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRG 67 TG+GS PGT REA+ +V GE L L ELPARGVGADM+GR GLLVD+A++ VP G Sbjct 54 TGVGSLPGTDPREASALVTGETPD-LPALPELPARGVGADMVGRTAGLLVDLAVEVVPTG 112 Query 68 YRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRA----VKVQAPGPVTLVAGLE 123 +R+ AR G RRA L+ D+DA +A C R+ VKV A GP TL A +E Sbjct 113 WRVTARQGRDLRRARDLMAGDLDAFGDA--------CDRSRPAWVKVSATGPWTLAAAVE 164 Query 124 LANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGV 183 LA+GHR +TD GAVR+ AASL EG+ AH A +A R VVVQ DEP LPA L G L Sbjct 165 LASGHRVLTDRGAVREFAASLGEGLRAHVAEVAARTGASVVVQLDEPGLPAVLAGSLPTA 224 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDA----- 238 + V + A+ LL + +DA V +H C+ P LL + ++AV +DA Sbjct 225 SGYGTVGSVPAPDAQDLLRELVTGIDAPVVVHCCADRPPIRLLAGAGVAAVGIDATRPAF 284 Query 239 --STLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSAL 296 ST + LDA+ + G ++LGL+P TAP R PS+ ++A + DRLG R L Sbjct 285 AGSTAEPRALDAIGETWDEGTPLLLGLLPGTAPAREPSIGDLARTGYDLADRLGFDRPRL 344 Query 297 RDRLGV-SPACGLANATGQWARTAVGLARDVAEAFARDPEAI 337 RL V +PACGLA AT +WAR A+ L+R++ AFA DP+ + Sbjct 345 A-RLAVPTPACGLAGATPEWARRALALSRELGRAFA-DPDEV 384 >gi|238063189|ref|ZP_04607898.1| methionine synthase, vitamin-B12 independent [Micromonospora sp. ATCC 39149] gi|237885000|gb|EEP73828.1| methionine synthase, vitamin-B12 independent [Micromonospora sp. ATCC 39149] Length=334 Score = 216 bits (549), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 146/331 (45%), Positives = 194/331 (59%), Gaps = 13/331 (3%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATGIGS PG EA +VV+GEL AL +L ELPARG GAD++GR GGLLV++ ++ Sbjct 13 ATGIGSLPGIDVAEAQRVVLGELP-ALPHLPELPARGPGADLIGRTGGLLVELPVELYAA 71 Query 67 GYRIAARPGAVTRRAASLLDEDMDAL-EEAWETAGLRGCGRAVKVQAPGPVTLVAGLELA 125 +R+A RPG RRA L++ D+D L E+A E AGL VKVQA GP TL AGL+L Sbjct 72 RWRVAPRPGRDLRRARDLMERDLDQLAEQAEEYAGL------VKVQAAGPYTLAAGLDLP 125 Query 126 NGHRAITDPGAVRDLAASLAEGVAAHRAALARRLD-TPVVVQFDEPSLPAALGGRLTGVT 184 G R + DPGAVRDLA SLAEG+ H AA+ARRL +++Q DEPSLPA L GR+ + Sbjct 126 IGGRMLRDPGAVRDLAGSLAEGLRVHVAAVARRLPRASLLLQLDEPSLPAVLAGRVPTES 185 Query 185 ALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAA 244 P+ + A ALL T I AV V +H C+PD+P +L++ + V++D ++ Sbjct 186 GFGTYRPVAQPDAAALLRTVIEAVGVPVVVHCCAPDVPLELIRSAGAVGVALDLGLVK-- 243 Query 245 DLDAVAAFVE--SGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGV 302 DLD + ++ G RAP+ EVA + DRLG PR L +++ V Sbjct 244 DLDPLGEVIDAGLGLLAGAAPATPPPGGRAPTSAEVADRVRQLWDRLGFPRRRLPEQVVV 303 Query 303 SPACGLANATGQWARTAVGLARDVAEAFARD 333 +P CGLA A + R + RD A D Sbjct 304 TPTCGLAGAPPEHVRAVLAACRDAGRRLAED 334 >gi|297156987|gb|ADI06699.1| hypothetical protein SBI_03578 [Streptomyces bingchenggensis BCW-1] Length=345 Score = 215 bits (548), Expect = 8e-54, Method: Compositional matrix adjust. Identities = 148/331 (45%), Positives = 193/331 (59%), Gaps = 10/331 (3%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 ATG+GS PG AREAA+ V G L L YL ELPARG GADM+GR G+LV+V P Sbjct 23 ATGVGSMPGGDAREAAKTVTGSLE-TLPYLPELPARGPGADMIGRTAGMLVEVYAHVEPS 81 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 G+RI+ RPG TRRA + L ED+DALEE T G +G A+KV A GP TL AGLEL Sbjct 82 GWRISDRPGRDTRRARAWLREDLDALEEF--TQGYQG---ALKVSAVGPWTLAAGLELRG 136 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGVTA 185 G A+ D GA RDL ASLAEG+ AH + RR+ VV+Q DEP L A GR+ + Sbjct 137 GEAALNDAGACRDLTASLAEGLRAHLEEVRRRVPGAEVVLQLDEPGLMAVALGRVRTASG 196 Query 186 LSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAAD 245 A +D V E L IA D V +HSC+P +P+ LL+R+ + VS D S L + Sbjct 197 YRTYAAVDRGVLEGALRDVIAVADGPVVVHSCAPGVPFGLLRRAGATGVSFDFSLLTERE 256 Query 246 LDAVAAFVESGRTVVLGLVPVT-APERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSP 304 +A+ VE G ++ +G VP T AP P+ + + RLG+ L + + V+P Sbjct 257 EEAIGEAVEGGTSLFVGAVPGTDAPLSDPAGSVMGVR--TLWRRLGLSPGILAESVVVTP 314 Query 305 ACGLANATGQWARTAVGLARDVAEAFARDPE 335 +CGLA A+ +AR A+ A + A +PE Sbjct 315 SCGLAGASPGYARAALAHCVRAARSLADNPE 345 >gi|254383200|ref|ZP_04998553.1| conserved hypothetical protein [Streptomyces sp. Mg1] gi|194342098|gb|EDX23064.1| conserved hypothetical protein [Streptomyces sp. Mg1] Length=327 Score = 215 bits (547), Expect = 9e-54, Method: Compositional matrix adjust. Identities = 143/333 (43%), Positives = 190/333 (58%), Gaps = 10/333 (3%) Query 5 ATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTV 64 A ATG+GS PG AREAA+ V G +L ELPARG GADM+GR+ GLLVD+ Sbjct 3 AGATGVGSLPGGDAREAAKTVTGSFE-EFPHLAELPARGPGADMIGRSLGLLVDMYAHVE 61 Query 65 PRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLEL 124 P G+RI+ RPG ++RA S L ED+DALEE T G G +KVQA GP TL LEL Sbjct 62 PSGWRISDRPGRDSKRARSWLGEDLDALEEF--TQGYEG---RLKVQAVGPWTLAGSLEL 116 Query 125 ANGHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGV 183 G + DPGA RDLAASLAEGV H A + +R+ +V+Q+DEPSL A L GR+ Sbjct 117 HGGEAMLQDPGACRDLAASLAEGVREHLADVRKRIPGAEIVLQYDEPSLTAVLLGRIRSA 176 Query 184 TALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQA 243 + +D V EA L A D +V +HSC+P++P+ LL+R+ + VS D S L Sbjct 177 SGYRTYRAVDRQVVEATLRELFAVHDGEVIVHSCAPEVPFGLLRRAGAAGVSFDFSLLTE 236 Query 244 ADLDAVAAFVESGRTVVLGLVP-VTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGV 302 + +A+ VE G + G+VP V P P + + RLG+ L + + V Sbjct 237 REDEAIGEAVEGGTKLFAGVVPGVDGPLSDPGGSVMGVR--KLWRRLGLAPGTLAESVVV 294 Query 303 SPACGLANATGQWARTAVGLARDVAEAFARDPE 335 +P+CGLA A+ +AR A + A +PE Sbjct 295 TPSCGLAGASPAYARAVQAHCVRAARSLADNPE 327 >gi|345009511|ref|YP_004811865.1| methionine synthase vitamin-B12 independent [Streptomyces violaceusniger Tu 4113] gi|344035860|gb|AEM81585.1| Methionine synthase vitamin-B12 independent [Streptomyces violaceusniger Tu 4113] Length=338 Score = 214 bits (545), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 141/331 (43%), Positives = 195/331 (59%), Gaps = 10/331 (3%) Query 7 ATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPR 66 A+G+GS PG AREA + V G L AL YL ELPARG GADM+GR G+LV++ P Sbjct 16 ASGVGSMPGDDAREAVKTVTGSLE-ALPYLPELPARGPGADMIGRTAGMLVELYAHVEPS 74 Query 67 GYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELAN 126 G+RI+ RPG TRRA + + ED+DALEE T G +G A+KV A GP TL A LEL Sbjct 75 GWRISDRPGRETRRARAWMGEDLDALEEF--TQGYQG---ALKVSAVGPWTLAASLELRG 129 Query 127 GHRAITDPGAVRDLAASLAEGVAAHRAALARRL-DTPVVVQFDEPSLPAALGGRLTGVTA 185 G A++DPGA RDL ASLAEG AH A + RR+ VV+Q DEPSL + L G + + Sbjct 130 GEVALSDPGACRDLTASLAEGCRAHLAEVRRRVPGAEVVLQLDEPSLTSVLRGSVRSASG 189 Query 186 LSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAAD 245 A +D V E L T + A V +HSC+P +P+ LL+R+ + +S S L ++ Sbjct 190 YRTHAAVDRGVVEGALRTLVEAAGGPVVVHSCAPAVPFGLLRRAGVEGISFPLSLLTESE 249 Query 246 LDAVAAFVESGRTVVLGLVPVT-APERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSP 304 +A+ VE G +++G VP T +P P+ + + RLG+ L + + ++P Sbjct 250 EEAIGEAVEGGTALLIGAVPGTDSPLSDPAGS--VSGVRTLWRRLGLSPETLAESVVITP 307 Query 305 ACGLANATGQWARTAVGLARDVAEAFARDPE 335 +CGLA A+ +AR A+ A + A +PE Sbjct 308 SCGLAGASPGYARAALAHCVQAARSLADNPE 338 Lambda K H 0.317 0.132 0.379 Gapped Lambda K H 0.267 0.0410 0.140 Effective search space used: 608281798996 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Sep 5, 2011 4:36 AM Number of letters in database: 5,219,829,388 Number of sequences in database: 15,229,318 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Neighboring words threshold: 11 Window for multiple hits: 40